[Comparative hemodynamic effects of 2 vasodilators: dihydralazine and diltiazem in permanent essential arterial hypertension].
Cardiac hemodynamic and diameter, blood flow velocity, volumic flow of the brachial artery measured by pulsed Doppler, were studied before and after diltiazem administration in comparison with dihydralazine in hypertensive patients. After diltiazem administration, blood pressure and total peripheral resistance significantly decreased (P less than 0.001) while cardiac index and heart rate increased (P less than 0.01). After 25 minutes perfusion cardiac output and heart rate returned toward control values, while blood pressure and total peripheral resistance remained decreased. The result contrasted with those observed after dihydralazine, which induced an increase in cardiac index and heart rate. The caliber of the brachial artery decreased significantly (P less than 0.001) after dihydralazine and increased after diltiazem (P less than 0.01). This study shows that 1). The antihypertensive effect of diltiazem was due to a fall in total peripheral resistance associated with a transient baroreflex mediated tachycardia, and 2) diltiazem dilated also large arteries.
D000328:Adult; D001158:Arteries / Q000187:drug effects; D001160:Arterioles / Q000187:drug effects; D001552:Benzazepines / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004078:Dihydralazine / Q000627:therapeutic use*; D004110:Diltiazem / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006830:Hydralazine / Q000031:analogs & derivatives*; D006973:Hypertension / Q000188:drug therapy*; D008875:Middle Aged; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents
D001552:Benzazepines; D014665:Vasodilator Agents; D006830:Hydralazine; D004110:Diltiazem; D004078:Dihydralazine
Effets hémodynamiques comparés de deux vasodilatateurs: la dihydralazine et le diltiazem dans l'hypertension artérielle permanente essentielle.