title: Effects of repetitive exercise on neonatal rat skeletal muscle oxidative capacity.
abstract: Since little is known about the training response to exercise in neonatal animals, this study was undertaken to elucidate the potential of oxidative system adaptations in developing skeletal muscle of rats during 50 days of daily treadmill running. The training regimen involved male and female rats (10 days old) initially running 0.1 mph, 0% grade, for 15 min. The program progressed to 1 mph, 25% grade, for 60 min by 50 days of age. At 25 days of age, pyruvate and palmitate oxidative capacity, and citrate synthase activity in red vastus muscle homogenates were elevated in the trained group (T) compared with age- and sex-matched controls (C). These increases were also observed for each subsequent time point tested and occurred in spite of the fact that the peak oxidative capacity of neonatal red vastus muscle was 46% greater than adult values. Further, trained animals tested at 45 days of age responded with a 12% increase in maximal oxygen consumption (Vo2max) compared with controls (P less than 0.05). Assays of muscle phosphofructokinase and of creatine phosphokinase activity conducted at this time point revealed no difference between T and C groups. Collectively, these data suggest that neonatal rats can be successfully trained and that they respond to an endurance-type program qualitatively similarly to adult rats.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001835:Body Weight; D006321:Heart / Q000033:anatomy & histology; D009132:Muscles / Q000201:enzymology / Q000378:metabolism*; D009929:Organ Size; D010084:Oxidation-Reduction; D010168:Palmitates / Q000378:metabolism; D005082:Physical Exertion; D011773:Pyruvates / Q000378:metabolism; D051381:Rats / Q000502:physiology*; D011919:Rats, Inbred Strains
chemical_list: D010168:Palmitates; D011773:Pyruvates