Effect of thyroidectomy on testicular enzymes of the pyruvate/malate cycle involved in lipogenesis.
The specific activities of testicular enzymes of the pyruvate/malate cycle involved in lipogenesis after thyroidectomy and thyroxine replacement were studied in prepubertal, pubertal and adult rats. Thyroidectomy induced testicular ATP citrate-lyase, malate dehydrogenase and malic enzyme activities and inhibited isocitrate dehydrogenase (NADP+) activity. Thyroxine treatment on thyroidectomized animals reverted all enzyme activities to normal. The result suggests that thyroid hormones have a differential effect on testicular enzymes of the pyruvate/malate cycle involved in lipogenesis.
D001275:ATP Citrate (pro-S)-Lyase / Q000378:metabolism*; D000375:Aging; D000818:Animals; D007521:Isocitrate Dehydrogenase / Q000378:metabolism*; D008055:Lipids / Q000096:biosynthesis*; D008291:Malate Dehydrogenase / Q000378:metabolism*; D008293:Malates / Q000378:metabolism*; D008297:Male; D011773:Pyruvates / Q000378:metabolism*; D019289:Pyruvic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D012741:Sexual Maturation; D013737:Testis / Q000187:drug effects / Q000201:enzymology*; D013965:Thyroidectomy; D013974:Thyroxine / Q000494:pharmacology
D008055:Lipids; D008293:Malates; D011773:Pyruvates; C030298:malic acid; D019289:Pyruvic Acid; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D001275:ATP Citrate (pro-S)-Lyase; D013974:Thyroxine