title: Growth activity in human septal cartilage: age-dependent incorporation of labeled sulfate in different anatomic locations.
abstract: Growth activity in different areas of human septal cartilage was measured by the in vitro incorporation of 35S-labeled NaSO4 into chondroitin sulfate. Septal cartilage without perichondrium was obtained during rhinoplasty from 36 patients aged 6 to 35 years. It could be shown that the anterior free end of the septum displays high growth activity in all age groups. The supra-premaxillary area displayed its highest growth activity during prepuberty, showing thereafter a continuous decline during puberty and adulthood. A similar age-dependent pattern in growth activity was found in the caudal prolongation of the septal cartilage. No age-dependent variations could be detected in the posterior area of the septal cartilage.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009300:Nasal Septum / Q000033:anatomy & histology / Q000254:growth & development* / Q000378:metabolism; D011627:Puberty; D013431:Sulfates / Q000378:metabolism; D013462:Sulfur Radioisotopes
chemical_list: D013431:Sulfates; D013462:Sulfur Radioisotopes