Passive transfer of diabetes in the BB/W rat.
Severe diabetes with insulitis was produced in young diabetes-prone BB/W rats by passive transfer of concanavalin A-treated spleen cells from BB/W animals with acute diabetes. Spleen cells alone or in combination with lymph node cells were active in transferring disease.
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D003920:Diabetes Mellitus / Q000209:etiology / Q000276:immunology*; D006943:Hyperglycemia / Q000209:etiology / Q000276:immunology; D007111:Immunity, Cellular; D051379:Mice; D008819:Mice, Nude; D051381:Rats; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000637:transplantation; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
D003208:Concanavalin A