[Implications of prostaglandins in neoplastic processes of human glandular epithelia, particularly the breast and prostate].
Prostaglandins (PGs) are a family of lipid compounds synthesized from polyunsaturated fatty acids derived from phospholipids, and divided into three main classes: primary PGs (including prostacyclin), thromboxanes, and leukotrienes. Though each member possesses marked activity on certain human biological functions, their precise role in physiological processes is uncertain, as they are present in very low quantities under normal or resting condition but show a marked increase in levels during benign or malignant pathological processes. This report mainly concerns neoplastic and preneoplastic phenomena, when PGs production is presented as being the consequence of altered cell function. This results from loss of the physiological state of tissue dependence of the cells, which acquire functional autonomy and become endowed with properties which appear to be important in cancer dissemination processes.
D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D011453:Prostaglandins / Q000096:biosynthesis / Q000502:physiology*; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000503:physiopathology*
D001095:Arachidonic Acids; D011453:Prostaglandins; D016718:Arachidonic Acid
Les implications des prostaglandines dans les processus néoplasiques des épithéliums glandulaires humains. En particulier le sein et la prostate.