Lung uptake of lidocaine in man as influenced by anaesthesia, mepivacaine infusion or lung insufficiency.
Pulmonary uptake of lidocaine was investigated in patients before surgery, and aimed at elucidating the influence of general anaesthesia, the presence of another local anaesthetic agent in the blood, or the possible impact of lung insufficiency. When the lung uptake of lidocaine, injected as a bolus together with indocyanine green dye, was calculated as uptake at 95% pass of the dye, there were no statistically significant differences between the four groups. When the extraction in each of the arterial blood samples was calculated on the basis of the relation between relative concentrations, there were statistically significant differences, with a general tendency towards higher extraction of lidocaine in the awake, healthy volunteers, not given mepivacaine, compared to the other groups. In the group in whom mepivacaine was infused, the arterial concentration of mepivacaine increased transiently after the injection of lidocaine. This probably reflects a displacement of mepivacaine from binding sites for both agents. From this study, it is postulated that the ability of the pulmonary circulation to clear the blood of lidocaine is high, and that it is not affected markedly by those situations studied in the present investigation.
D000328:Adult; D000368:Aged; D004329:Droperidol / Q000494:pharmacology; D005283:Fentanyl / Q000494:pharmacology; D006801:Humans; D007208:Indocyanine Green; D008012:Lidocaine / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D008619:Mepivacaine / Q000378:metabolism* / Q000494:pharmacology; D008875:Middle Aged; D011652:Pulmonary Circulation; D012131:Respiratory Insufficiency / Q000378:metabolism*
D008012:Lidocaine; D008619:Mepivacaine; D007208:Indocyanine Green; D004329:Droperidol; D005283:Fentanyl