[Effect of prostaglandin-synthetase inhibitors on responses of segments of coronary arteries to 4-methylesculetol and/or to angiotensin II].
The aim of this work is to study the mechanism by which 4-methylesculetin (4-Me) causes the relaxation or inhibits the angiotensin-2 (ATN2) induced contraction in the smooth muscle. The effect of 4-Me, alone or associated with ascorbic acid, on basal tone and ATN2 induced contraction of isolated coronary strips have been studied. Experiments have been carried out in the presence of lysine acetylsalicylate (LAS) and indomethacin (IN), specific inhibitors of prostaglandin-synthetase. Both LAS and IN decreased, but did not abolish, the 4-Me induced relaxation and suppressed the depressive effect of 4-Me on the ATN2 dependent contraction. Therefore, it seems reasonable to conclude that the 4-Me influence could be mediated by prostaglandins release in the smooth muscle.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001241:Aspirin / Q000031:analogs & derivatives / Q000494:pharmacology; D002417:Cattle; D003331:Coronary Vessels / Q000187:drug effects*; D016861:Cyclooxygenase Inhibitors; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D008239:Lysine / Q000031:analogs & derivatives / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D012603:Scopoletin / Q000494:pharmacology*; D014468:Umbelliferones / Q000494:pharmacology*
D016861:Cyclooxygenase Inhibitors; D004791:Enzyme Inhibitors; D014468:Umbelliferones; D000804:Angiotensin II; D008239:Lysine; D012603:Scopoletin; D001205:Ascorbic Acid; D001241:Aspirin; C010395:acetylsalicylic acid lysinate; D007213:Indomethacin
Effetto di inibitori della PG-sintetasi sulle risposte di segmenti di arterie coronarie al 4-metilesculetolo e/o all'angiotensina II.