Antigenic cross-reactions between woodchuck hepatitis virus and human hepatitis B virus shown by immune electron microscopy.
Using immune electron microscopy (IEM), low-level cross-reactions could be demonstrated between the surface antigens of hepatitis B and woodchuck hepatitis. However, immune complex formation was greatly enhanced by pre-exposure of the antigens to 0.5% deoxycholate. Cross-reaction between the core antigens and e antigens of both viruses was also confirmed by IEM as well as radioimmunoassay. It appears that the woodchuck sera used in this study may well contain an anti-immunoglobulin akin to rheumatoid factor.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D003429:Cross Reactions; D006512:Hepatitis B Core Antigens / Q000032:analysis; D006513:Hepatitis B e Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000276:immunology; D006518:Hepatitis Viruses / Q000276:immunology*; D008392:Marmota; D008854:Microscopy, Electron
D000956:Antigens, Viral; D006512:Hepatitis B Core Antigens; D006513:Hepatitis B e Antigens