3-O-demethyl-2,3-di-epi-fortimicins and 3-O-demethyl-3-epi-fortimicins.
Syntheses of the 3-O-demethyl-2,3-di-epi-fortimicins A and B and the 3-O-demethyl-3-epi-fortimicins A and B have been accomplished in processes the key steps of which were solvolyses of 4-N-acetyl-3-O-demethyl-3-O-methanesulfonylfortimicin derivatives. Antibacterial activities of the new antibiotics are reported.
D000617:Aminoglycosides / Q000138:chemical synthesis / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C037746:3-O-demethylfortimicin B; C027445:3-O-demethylfortimicin A