[Contact (prekallikrein) and fibrinolytic (plasminogen/antiplasmin value) system in the physiopathology of vascular complications of diabetes].
Both micro and macro-angiopathy involve interaction of blood vessel and plasma factors which may be altered in diabetes. Little is known concerning changes in contact and fibrinolysis factors as prekallikrein, plasminogen and fast antiplasmin in diabetes. We tested also the plasminogen/antiplasmin ratio in 151 diabetics and 64 normal subjects (18 to 74 years old). Our conclusion is:--the absence of correlation between the clinical characteristic of diabetes and prekallikrein level,--the decrease of plasminogen/antiplasmin ratio in complicated diabetes,--in complicated diabetes, correlation between antithrombin III, VIII factor and fibrinogen levels, perhaps, in relation with inflammation signs.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000502:physiology; D003920:Diabetes Mellitus / Q000097:blood; D003925:Diabetic Angiopathies / Q000097:blood*; D005169:Factor VIII / Q000502:physiology; D005340:Fibrinogen / Q000502:physiology; D005342:Fibrinolysis; D006801:Humans; D007610:Kallikreins / Q000502:physiology*; D008875:Middle Aged; D010958:Plasminogen / Q000502:physiology*; D011288:Prekallikrein / Q000502:physiology*; D000979:alpha-2-Antiplasmin / Q000502:physiology*
D000979:alpha-2-Antiplasmin; D000990:Antithrombin III; D005169:Factor VIII; D005340:Fibrinogen; D010958:Plasminogen; D011288:Prekallikrein; D007610:Kallikreins
Apport de l'étude du système contact (prékallicréine) et fibrinolytique (rapport plasminogène/antiplasmine) à l'approche physiopathologique des complications vasculaires du diabète.