Effect of testosterone and oxandrolone on thrombocyte aggregation and synthesis of prostaglandins in thrombocytes and aorta of atherosclerosis-susceptible pigeons.
Effect of intramuscular administration (10 mg/kg/week) of testosterone and oxandrolone on a) thrombocyte aggregation and b) synthesis of prostaglandins from [14C]-arachidonic acid in thrombocytes and aorta of atherosclerosis-susceptible White Carneau pigeon was examined. Neither testosterone nor oxandrolone influenced collagen, ADP and arachidonic acid induced aggregation or the synthesis of prostaglandins in thrombocytes. However, both testosterone and oxandrolone stimulated (p less than 0.05) the synthesis of 6-keto-PGF1 alpha (stable product of prostacyclin) und PGE2 in aorta.
D000818:Animals; D001011:Aorta / Q000187:drug effects*; D001161:Arteriosclerosis / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D010856:Columbidae; D005260:Female; D008297:Male; D010074:Oxandrolone / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D011453:Prostaglandins / Q000096:biosynthesis*; D012737:Sex Factors; D013739:Testosterone / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
D011453:Prostaglandins; D014280:Triglycerides; D013739:Testosterone; D010074:Oxandrolone; D002784:Cholesterol