Efficacy of diazoxide in preventing hypoglycemia in a child affected by hypopituitary dwarfism.
An observation is reported of the efficacy of diazoxide (10 mg/kg/24 h) in the prevention of hypoglycemic crises in a child with growth hormone deficiency. The success of the therapy may be attributed to a reduction of glucose uptake induced by the drug, rather than to the inhibition of insulin secretion which is already depressed in subjects affected by growth hormone deficiency. The availability of a drug with no serious and irreversible side effects, capable of preventing hypoglycemic crises in patients with hormone deficiency, seems to be important whenever it is not possible to immediately start a replacement therapy.
D001786:Blood Glucose / Q000032:analysis; D002675:Child, Preschool; D003981:Diazoxide / Q000627:therapeutic use*; D004393:Dwarfism, Pituitary / Q000150:complications*; D013006:Growth Hormone / Q000172:deficiency; D006801:Humans; D007003:Hypoglycemia / Q000517:prevention & control*; D008297:Male
D001786:Blood Glucose; D013006:Growth Hormone; D003981:Diazoxide