[Factor analysis of the structure-activity relationship of di- and triphenylethylenes in 2 biochemical tests].
This paper deals with the study of biochemical activity, by means of correspondence analysis, of about fifty original molecules of di- and triphenylethylene structures. The pharmacological experiments were made on glutamate deshydrogenase and prostaglandine synthetase. A typology of several molecular groups is established and the effects of various substituents are specified.
D000818:Animals; D002417:Cattle; D005969:Glutamate Dehydrogenase / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D008297:Male; D008861:Microsomes / Q000201:enzymology; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D012669:Seminal Vesicles / Q000201:enzymology; D013267:Stilbenes / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D013267:Stilbenes; D011451:Prostaglandin-Endoperoxide Synthases; D005969:Glutamate Dehydrogenase
Analyse au moyen d'un traitement factoriel des relations structure-activité de di-et triphénylethylènes sur deux tests biochimiques.