Pharmacokinetic predictions based on a variable dosage frequency in chronic treatment.
After repeated intramuscular or oral administration, plasma drug levels are predicted by using a programmable calculator. Predictions are based on a one-compartment, open model with first-order absorption. The actual times of dosing are considered, so that the assumption of a constant dosing interval is not required. A brief analysis of the pharmacokinetic consequences that may result from a variable dosage frequency is presented.
D003201:Computers; D004334:Drug Administration Schedule; D006801:Humans; D007700:Kinetics; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D013806:Theophylline / Q000378:metabolism
D004364:Pharmaceutical Preparations; D013806:Theophylline