[Obzidan inhibition of lipid free-radical peroxidation in coronary-occluding myocardial infarct].
Studies on spontaneous lipid chemiluminescence, the concentration of malonic dialdehyde and Schiff bases in the zone of ischemia and myocardial infarction in rats with myocardial infarction induced by coronary occlusion have shown that obsidan (propranolol) inhibits free radical lipid peroxidation. The drug increases the animals' survival rate, improves the ECG readings, diminishes the size of the infarct zone, reduces the number of postcoronary occlusion arrhythmias, and exerts an antifibrillatory action. Inhibition of free radical lipid peroxidation plays a role in the therapeutic effect of obsidan.
D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005609:Free Radicals; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D011433:Propranolol / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors
D005609:Free Radicals; D008054:Lipid Peroxides; D011433:Propranolol
Ingibirovanie obzidanom perekisnogo svobodnoradikal'nogo okisleniia lipidov pri koronarookkliuzionnom zinfarkte miokarda.