Stability of liposomes in circulation is markedly enhanced by structural modification of their phospholipid component.
Replacement of the C-2 ester group in phosphatidylcholine by the carbamyloxy function rendered its liposomes completely stable and longer living in the circulation of rats.
D000818:Animals; D001769:Blood; D002784:Cholesterol; D008081:Liposomes / Q000008:administration & dosage*; D010713:Phosphatidylcholines; D010743:Phospholipids; D051381:Rats; D013997:Time Factors
D008081:Liposomes; D010713:Phosphatidylcholines; D010743:Phospholipids; C037754:1-palmitoyl-2-heptadec-10-enylcarbamyloxy-sn-glycero-3-phosphorylcholine; D002784:Cholesterol