Comparison of the effectiveness of several formulations of sodium valproate: tablets, enteric-coated capsules, solutions and rectal capsules.
The effects of an oral enteric-coated preparation (VAL 579 capsules) of sodium valproate (VPA) were compared with those of conventional oral and rectal preparations in 24 epileptic patients. Enteric-coated capsules are useful for avoiding gastric intolerance to VPA. Plasma VPA level peaks after the enteric- coated form were later than after other forms. The bioavailability appeared to be the same for all the forms.
D000293:Adolescent; D000328:Adult; D002214:Capsules; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D007223:Infant; D012007:Rectum; D012996:Solutions; D013488:Suppositories; D013607:Tablets; D013608:Tablets, Enteric-Coated; D014635:Valproic Acid / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use
D002214:Capsules; D012996:Solutions; D013488:Suppositories; D013607:Tablets; D013608:Tablets, Enteric-Coated; D014635:Valproic Acid