Diminution of chemically induced lung neoplasia in mice by phenobarbital pre-treatment.
Pre-treatment of 21-day-old ICR/Jcl mice with 75 micrograms/g of phenobarbital significantly reduced the yields of lung tumors induced by 4-nitroquinoline-1-oxide (4NQO) and furylfuramide. Dimethylbenz[a]anthracene (DMBA)- and urethane-induced lung tumorigenesis was also reduced, but was not significantly different from that in mice receiving only the carcinogen. However, 6 consecutive treatments with phenobarbital (40 micrograms/g) in adult mice greatly reduced urethane-induced lung tumorigenesis. Post-treatment with an equal dose of phenobarbital showed neither diminution nor enhancement of tumorigenesis.
D015112:4-Nitroquinoline-1-oxide; D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology; D000818:Animals; D008175:Lung Neoplasms / Q000139:chemically induced*; D051379:Mice; D008813:Mice, Inbred ICR; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010634:Phenobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D014520:Urethane / Q000008:administration & dosage / Q000494:pharmacology
D014520:Urethane; D015112:4-Nitroquinoline-1-oxide; D015127:9,10-Dimethyl-1,2-benzanthracene; D010634:Phenobarbital