Hematologic characterization of naturally occurring malaria (Plasmodium inui) in cynomolgus monkeys (Macaca fascicularis).
Twenty of 47 recently imported cynomolgus monkeys (Macaca fascicularis) were found to have malarial infections. The agent identified was Plasmodium inui. All infections were subclinical in nature. Parasitemias ranged from 10 to 900 parasites/mm3 of whole blood. Pre- and post-treatment hematologic values were evaluated following treatment with chloroquine. Treatment was effective in clearing parasitemias from 13 of 14 infected monkeys. Pretreatment values of hematocrit, hemoglobin, and mean corpuscular volume were significantly different in infected animals compared to noninfected animals. While post-treatment hemoglobin and hematocrit values returned to noninfected control levels, mean corpuscular volume values of infected animals remained significantly lower in the post-treatment period.
D000818:Animals; D002738:Chloroquine / Q000494:pharmacology / Q000627:therapeutic use; D004906:Erythrocyte Count / Q000662:veterinary; D004909:Erythrocyte Indices / Q000662:veterinary; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D008251:Macaca / Q000097:blood*; D008252:Macaca fascicularis / Q000097:blood*; D008288:Malaria / Q000097:blood / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D008297:Male; D008992:Monkey Diseases / Q000097:blood* / Q000188:drug therapy / Q000469:parasitology; D010961:Plasmodium / Q000187:drug effects
D006454:Hemoglobins; D002738:Chloroquine