Cleft palate susceptibility maps in two H-2 subregions, H-2K to I-B and G to H-2D.
Data presented here defines the map of H-2 associated genes which affect the glucocorticoid-induced cleft palate frequency to the regions H-2K to I-B and G to H-2D. This was done by observing in four congenic strains the frequency of cleft palate induced by 160 mg/kg of dexamethasone administered to pregnant females on day 12 of gestation. The strains used were B10.A/Sg.Sn, C57BL/10Sn, B10.A (5R)/SgSn and B10.A(18R)/Sg. Additionally the cleft palate frequency was observed in a large number of litters from saline-treated pregnant females. The cleft palate frequency in this control was very low and the rank of strains was the same as for the glucocorticoid-induced cleft-palate frequency. This observation suggests that the induced cleft palate frequency reflects the spontaneous occurrence of isolated cleft palate in these strains.
D000818:Animals; D002971:Cleft Lip / Q000139:chemically induced / Q000235:genetics; D002972:Cleft Palate / Q000139:chemically induced / Q000235:genetics*; D003907:Dexamethasone; D005260:Female; D005787:Gene Frequency; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D011247:Pregnancy; D011995:Recombination, Genetic; D012965:Sodium Chloride
D006183:H-2 Antigens; D012965:Sodium Chloride; D003907:Dexamethasone