Quantitative biliary dynamics: introduction of a new noninvasive scintigraphic technique.
We used a Tc-99m-labeled hepatobiliary agent to measure the partition of hepatic bile between gallbladder and intestine in sixteen normal patients and nine patients with cholelithiasis. In normal subjects, the fractions of the hepatic bile that flow into the gallbladder and the small intestine were widely variable, with mean values of 69 +/- 7% (s.e.) and 31 +/- 7% respectively. Bile reflux into the common hepatic duct was rare, occurring during the first 2/3 of the gallbladder ejection period and only when the ejection fraction was greater than 59%. The gallbladder's mean latent period, ejection period, ejection fraction, and ejection rate were 2 +/- 1 min, 11 +/- 1 min, 59 +/- 4%, and 5.9%/min respectively. In patients with cholelithiasis, the fraction of hepatic bile flowing into the gallbladder was normal, but the ejection fraction was significantly reduced (p less than 0.005). For an equivalent dose of cholecystokinin, the gallbladder in cholelithiasis is less responsive than in normal subjects.
D000328:Adult; D000818:Animals; D001655:Bile Reflux / Q000000981:diagnostic imaging; D002766:Cholecystokinin / Q000494:pharmacology; D002769:Cholelithiasis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000502:physiology; D006500:Hepatic Duct, Common / Q000000981:diagnostic imaging; D006801:Humans; D007098:Imino Acids; D008297:Male; D008875:Middle Aged; D011817:Rabbits; D011877:Radionuclide Imaging; D013667:Technetium; D019780:Technetium Tc 99m Lidofenin; D013679:Technology, Radiologic
D007098:Imino Acids; D019780:Technetium Tc 99m Lidofenin; D013667:Technetium; D002766:Cholecystokinin