title: Normal hydroxylation of proline in collagen synthesized by skin fibroblasts from a patient with prolidase deficiency.
abstract: The extent of hydroxylation of proline in collagen synthesized and secreted into the culture medium by skin fibroblasts derived from a patient with prolidase deficiency has been examined and found to be normal. It would seem likely that to a considerable extent the urinary proline-containing dipeptides apparent in this condition are derived from sources other than collagen.
mesh_terms: D000328:Adult; D002648:Child; D003094:Collagen / Q000378:metabolism*; D004150:Dipeptidases / Q000172:deficiency*; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D006900:Hydroxylation; D007231:Infant, Newborn; D011392:Proline / Q000096:biosynthesis*; D012867:Skin / Q000378:metabolism*
chemical_list: D003094:Collagen; D011392:Proline; D004150:Dipeptidases; C022449:proline dipeptidase