Effect of acetylsalicylic acid on vascular damage and myointimal proliferation in canine pulmonary arteries subjected to chronic injury by Dirofilaria immitis.
The effect of aspirin (ASA) on pulmonary artery response to chronic injury induced by Dirofilaria immitis was assessed in the dog. Eight dogs were studied for 30 days after adult heartworms were transplanted into the pulmonary arteries. Four dogs were treated with ASA (325 mg/day given orally) starting 3 days before the transplantation was done. Evan's blue dye was used to locate areas of vascular damage. Vascular morphology was assessed by scanning electron microscopy and light microscopy. According to results of the morphologic studies, nontreated dogs had extensive endothelial damage and significant adhesion of leukocytes and blood platelets. Blood vessels of ASA-treated dogs had less endothelial damage. Platelet adhesion on areas of vascular damage was less than that observed in nontreated dogs. Myointimal proliferative lesions were observed in both nontreated and ASA-treated dogs. However, the lesions in nontreated dogs were larger (means 68 +/- 7 mm2) and more complex than those in ASA-treated dogs (means 20 +/- 1 mm2). The results indicated that aspirin may protect against development of myointimal proliferation resulting from chronic vascular injury. The mechanism of the ASA protection may result from a combination of antiplatelet and anti-inflammatory effects, as well as a direct protective effect on vascular endothelium.
D000818:Animals; D001241:Aspirin / Q000627:therapeutic use*; D002908:Chronic Disease; D004183:Dirofilaria immitis; D004184:Dirofilariasis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D004727:Endothelium / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D011651:Pulmonary Artery / Q000473:pathology* / Q000648:ultrastructure
D001241:Aspirin