Amino acid sequence of the unique 3,5,3'-triiodothyronine-containing sequence from porcine thyroglobulin.
A unique T3-containing peptide was isolated by chemical and enzyme treatments from pTgb of different iodine contents and microsequenced: Leu-Ala-Ser-Lys-Ser-T3. This site can also form T4 to a small extent. It contains all the T3 of the protein and presents a special susceptibility to proteolysis thus suggesting a likely mechanism to explain that the thyroid secretes T3 preferentially to T4 in vivo.
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D055598:Chemical Phenomena; D002621:Chemistry; D006868:Hydrolysis; D007455:Iodine / Q000302:isolation & purification; D010446:Peptide Fragments / Q000302:isolation & purification; D013552:Swine; D013954:Thyroglobulin; D014284:Triiodothyronine
D010446:Peptide Fragments; D014284:Triiodothyronine; D013954:Thyroglobulin; D007455:Iodine