Liver and skeletal muscle metabolism, extracellular K+ concentrations, and survival in spontaneously hypertensive rats following acute blood loss.
The metabolic responses of spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) to acute blood loss (30% of the calculated blood volume) have been studied. The initial mean arterial pressure (MAP) was 179 mmHg in SHR and 105 mmHg in WKY. After bleeding, MAP decreased to about 50 mmHg in both groups. SHR failed to increase MAP in the posthemorrhagic period, while in WKY a level of 65-70 mmHg was reached. Metabolic changes in liver and skeletal muscle, indicative of tissue hypoxia, occurred earlier and were more pronounced in SHR than in WKY. In SHR, the ATP content of the liver was almost depleted within 1 h, while during the same time period only a moderate reduction was seen in WKY. Extracellular K+ concentration in sketetal muscle increased more rapidly in SHR than in WKY, but a similar relationship between lactate content and extracellular K+ concentration was found in both groups. The mean posthemorrhagic survival time was only 47 min for SHR, as compared to 193 min for WKY. The present results indicate that a blood loss is more detrimental for hypertensive than normotensive rats.
D000208:Acute Disease; D000818:Animals; D001794:Blood Pressure; D001815:Bloodletting; D005110:Extracellular Space / Q000378:metabolism*; D006400:Hematocrit; D006470:Hemorrhage / Q000401:mortality / Q000503:physiopathology; D006973:Hypertension / Q000503:physiopathology*; D007773:Lactates / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D007773:Lactates; D011188:Potassium