Putrescine dependent growth of mycoplasma infected mammalian cells.
The aliphatic diamine putrescine, a metabolic precursor of the polyamines spermidine and spermine, markedly stimulated the growth of a murine lymphoblastoid cell line (R 1.1) infected with Mycoplasma orale, under conditions of arginine limitation. The diamine acted by suppressing the growth of the mycoplasma, which use arginine as a major energy source, and thereby prevented the depletion of arginine from the medium. The antimycoplasmal effects of putrescine occurred at concentrations that were neither stimulatory nor toxic to uninfected cells.
D000818:Animals; D001120:Arginine / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D051379:Mice; D009174:Mycoplasma / Q000254:growth & development; D009175:Mycoplasma Infections / Q000188:drug therapy / Q000503:physiopathology*; D011700:Putrescine / Q000494:pharmacology* / Q000627:therapeutic use
D001120:Arginine; D011700:Putrescine