Prostaglandin synthetase-catalyzed activation of phenacetin metabolites to genotoxic products.
D000082:Acetaminophen / Q000378:metabolism; D000627:Aminophenols / Q000633:toxicity; D000818:Animals; D001711:Biotransformation; D004247:DNA; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D010615:Phenacetin / Q000378:metabolism* / Q000633:toxicity; D011451:Prostaglandin-Endoperoxide Synthases / Q000494:pharmacology*; D011817:Rabbits; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced
D000627:Aminophenols; D000082:Acetaminophen; D004247:DNA; D011451:Prostaglandin-Endoperoxide Synthases; D010615:Phenacetin; D005978:Glutathione