Age-related effect of cycloheximide on lipid peroxidation in rough and smooth microsomes of rat liver.
Cycloheximide, at a nonlethal dose of 2 mg/kg body weight, has different effects on microsomal in vivo lipid peroxidation in different age groups. In general, the antibiotic increases microsomal lipid peroxidation in newborn and 1-year-old rats, but decreases it in 15- and 75-day-old rats. Low doses of cycloheximide induces lipid peroxidation in vitro whereas higher doses cause inhibition. The degree of change differs in the two microsomal fractions. The sucklings are more susceptible to such a change than the older rats. In vivo lipid peroxidation in rat liver homogenate and rough and smooth microsomes declines as a function of age. Smooth microsomes show more lipid peroxidation than the rough in the different age groups.
D000375:Aging; D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology*; D005260:Female; D008054:Lipid Peroxides / Q000378:metabolism*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D008054:Lipid Peroxides; D003513:Cycloheximide