Persistent Strongyloides stercoralis in a blind loop of the bowel. Successful treatment with mebendazole.
Three courses of thiabendazole therapy, including one course given directly into a blind loop of the bowel, failed to eradicate Strongyloides stercoralis from a 55-year-old man who had undergone a Roux-en-Y operation. The patient responded to 1.5 g/day of mebendazole for 14 days, and the infection did not recur. Our case illustrates the difficulty of eliminating S stercoralis from a blind loop of the bowel and indicates that mebendazole therapy used in adequate doses is effective treatment for strongyloidiasis. The lack of toxicity of mebendazole makes it a desirable drug for Strongyloides infestation resistant to thiabendazole therapy.
D001562:Benzimidazoles / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy*; D008297:Male; D008463:Mebendazole / Q000627:therapeutic use*; D008875:Middle Aged; D010437:Peptic Ulcer / Q000601:surgery; D013322:Strongyloidiasis / Q000188:drug therapy*; D013827:Thiabendazole / Q000627:therapeutic use
D001562:Benzimidazoles; D008463:Mebendazole; D013827:Thiabendazole