Polyamine depletion influences drug-induced chromosomal damage.
Polyamines have been implicated in the intracellular stabilization of DNA. Depletion of intracellular polyamines influences the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and cis-diamminedichloroplatinum II. By means of the sister chromatid exchange assay, it was found that intracellular polyamine depletion can also alter the induction of chromosomal damage by these cytotoxic agents.
D000818:Animals; D002330:Carmustine / Q000494:pharmacology; D002875:Chromosomes / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology; D004247:DNA / Q000378:metabolism; D000518:Eflornithine; D009690:Nucleic Acid Conformation; D009952:Ornithine / Q000031:analogs & derivatives / Q000494:pharmacology; D011073:Polyamines / Q000378:metabolism*; D011700:Putrescine; D051381:Rats; D012854:Sister Chromatid Exchange; D013095:Spermidine; D013096:Spermine
D011073:Polyamines; D013096:Spermine; D004247:DNA; D009952:Ornithine; D002945:Cisplatin; D002330:Carmustine; D013095:Spermidine; D011700:Putrescine; D000518:Eflornithine