The effect of Lampit on Trypanosoma rangeli in experimentally infected mice.
Mice experimentally inoculated with metacyclic forms of Trypanosoma rangeli were given orally 10, 25, 50 or 100 mg/kg of body weight/day of Lampit on 20 consecutive days. The results of combined examinations of fresh blood, Giemsa stained blood preparations, blood cultures, blood concentration, repeated xenodiagnosis with Rhodnius prolixus and blind passages via triatomine bites to other mice demonstrated that a dose of 50 to 100 mg/kg/day of the drug eliminated T. rangeli from the blood of all mice in the first seven days of treatment. In mice receiving 10 or 25 mg/kg/day of drug, 60% and 30% respectively still harboured trypanosomes 90 days after infection. The results indicate that Lampit is at least as effective against T. rangeli as it is against T. cruzi in mice.
D000284:Administration, Oral; D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D051379:Mice; D009547:Nifurtimox / Q000008:administration & dosage*; D009581:Nitrofurans / Q000008:administration & dosage*; D014345:Trypanosoma / Q000187:drug effects
D009581:Nitrofurans; D009547:Nifurtimox