Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production.
Corticosteroids have profound effects on functions of the macrophage associated with antigen presentation to T cells. The drugs inhibited the expression of surface I-region-associated (Ia) antigens by peritoneal macrophages both in vitro and in vivo, reduced the production of IL 1, and inhibited antigen presentation for T cell proliferation by macrophages. The doses of hydrocortisone and prednisolone that inhibited by 50% Ia expression in cultured macrophages ranged around 2 to 5 x 10(-8) M. These results could explain one mechanism by which corticosteroids suppress the induction of immune responses.
D000818:Animals; D003864:Depression, Chemical; D005802:Genes, MHC Class II; D006854:Hydrocortisone / Q000494:pharmacology*; D007375:Interleukin-1 / Q000096:biosynthesis; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D011239:Prednisolone / Q000494:pharmacology*
D007375:Interleukin-1; D011239:Prednisolone; D006854:Hydrocortisone