title: 2-(Aminomethyl)phenols, a new class of saluretic agents. 5. Fused-ring analogues.
abstract: A number of bicyclic ring-fused analogues of 2-(aminomethyl)phenol were synthesized and tested orally in rats and intravenously in dogs for saluretic and diuretic effects. Of the 15 alicylic, aromatic, and heterocyclic ring-fused compounds tested, only 2-(aminomethyl)-4-chloro-1-naphthalenol hydrochloride (2) and 7-(aminomethyl)-6-hydroxy-5,8-dimethyl-1,2,3,4-tetrahydronaphthalene hydrochloride (6) displayed a high order of activity.
mesh_terms: D000588:Amines / Q000494:pharmacology*; D000818:Animals; D001596:Benzylamines / Q000138:chemical synthesis / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000138:chemical synthesis*; D004285:Dogs; D051381:Rats; D012965:Sodium Chloride / Q000652:urine; D013329:Structure-Activity Relationship
chemical_list: D000588:Amines; D001596:Benzylamines; D004232:Diuretics; D012965:Sodium Chloride; C032416:2-(aminomethyl)phenol