title: Hyposplenism in primary systemic amyloidosis.
abstract: Twenty-two of 91 (24%) patients with primary systemic amyloidosis were functionally hyposplenic. This group, identified by blood smear findings, had a different survival distribution when compared with a normosplenic group (p less than 0.0001). The peripheral blood smear was more sensitive than the splenic scan for a diagnosis of hyposplenism. Amyloidosis should be included in the differential diagnosis of acquired hyposplenism in the adult.
mesh_terms: D000686:Amyloidosis / Q000097:blood / Q000150:complications*; D001777:Blood Coagulation; D004908:Erythrocyte Inclusions / Q000473:pathology; D005260:Female; D006333:Heart Failure / Q000209:etiology; D006529:Hepatomegaly / Q000209:etiology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D013158:Splenic Diseases / Q000097:blood / Q000209:etiology*
chemical_list: D007136:Immunoglobulins