title: [DOCA-salt hypertension in cats].
abstract: The possibility of reproducing DOCA-salt hypertension in cats has been explored. It has been shown that administration of DOCA and sodium chloride may result in the development of a hypertensive condition in some of cats. Unilateral nephrectomy increases the probability of hypertension occurrence. To attain a steady and noticeable (up to 190 +/- 8/146 +/- 7 mm Hg) elevation of arterial pressure, it is necessary that appreciable amounts of DOCA and sodium chloride be administered for a long time (during 6 months) in the presence of unilateral nephrectomy. The hypertension thus induced is marked by the increased (71%) overall peripheral resistance and by the decreased cardiac output, which rises for a short period in the course of hypertension development.
mesh_terms: D000818:Animals; D002415:Cats; D003900:Desoxycorticosterone / Q000494:pharmacology*; D004195:Disease Models, Animal; D004562:Electrocardiography; D006439:Hemodynamics / Q000187:drug effects; D006973:Hypertension / Q000139:chemically induced* / Q000503:physiopathology; D012965:Sodium Chloride / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D003900:Desoxycorticosterone; D012965:Sodium Chloride
vernacular_title: DOKA-solevaia gipertenziia u koshek.