Pharmacokinetics of warfarin in rabbits during short-term and long-term uraemia.
Warfarin was administered intravenously twice at an interval of six months to rabbits with surgically-induced impairment of renal function and to control animals. Pharmacokinetic analysis showed that the elimination rate of warfarin was significantly decreased in the uraemic group after 2 weeks duration of uraemia and was even further decreased at the second examination 6 months later. No significant changes in the volumes of distribution were found. Renal function tests indicated stable renal function between the two examinations.
D000818:Animals; D002860:Chromium Radioisotopes; D004492:Edetic Acid / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D011817:Rabbits / Q000378:metabolism*; D013997:Time Factors; D014511:Uremia / Q000378:metabolism*; D014859:Warfarin / Q000378:metabolism*
D002860:Chromium Radioisotopes; D014859:Warfarin; D004492:Edetic Acid