Effect of 6-hydroxydopamine lesions of the medial forebrain bundle on the distribution of cholecystokinin in rat forebrain.
The quantitative contribution of ascending dopaminergic fibers of the medial forebrain bundle to the cholecystokinin-like immunoreactivity (CCK-LI) in rat forebrain areas has been studied using unilateral 6-hydroxydopamine lesions of this pathway. The lesions produced depletions of CCK-LI in only two of the 18 areas studied. The results suggest that the terminal areas of the mesolimbic dopamine neurons also contain substantial CCK-LI innervations from other non-dopaminergic neurons.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002766:Cholecystokinin / Q000378:metabolism*; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D009928:Organ Specificity; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains
D006892:Hydroxydopamines; D016627:Oxidopamine; D002766:Cholecystokinin