title: Colloid osmotic pressure in infants with hyaline membrane disease.
abstract: Colloid osmotic pressure (COP) was measured serially in 81 critically ill neonates with hyaline membrane disease (HMD) during the first five days of life, and these changes were correlated with the birth weight, gestational age, serum protein level, clinical status, and outcome. Colloid osmotic pressure correlated better with the total protein level (n = 81; r = 0.54) than with birth weight (r = 0.23) and gestational age (r = 0.31; n = 81). Seventy-one of 81 neonates survived. Among the survivors, COP increased significantly by day 5, whereas changes in the total protein level were not significant during the same period. Colloid osmotic pressure decreased significantly in nine of ten nonsurvivors (mean +/- SE, 11 +/- 0.5 to 8 +/- 0.55 mm Hg), whereas the total protein level did not show a similar change. Thus, COP cannot be accurately predicted by measuring serum protein during acute illness. Serial measurement of COP was a better prognostic indicator than the total protein level in infants with HMD.
mesh_terms: D001724:Birth Weight; D001798:Blood Proteins / Q000032:analysis; D002199:Capillary Permeability; D003102:Colloids; D005865:Gestational Age; D006801:Humans; D006819:Hyaline Membrane Disease / Q000175:diagnosis* / Q000503:physiopathology; D007231:Infant, Newborn; D009997:Osmotic Pressure; D011446:Prospective Studies
chemical_list: D001798:Blood Proteins; D003102:Colloids