Reduced faecal blood loss in patients receiving choline magnesium trisalicylate ('Trilisate') when compared with aspirin.
A study was carried out in 16 healthy male volunteers to compare the effects on faecal blood loss of comparable daily doses of choline magnesium trisalicylate (3 g) and acetylsalicylic acid (2.4 g) given over a period of 7 days. Faecal blood loss was measured by 51Cr labelling of red cells. Haematological parameters were also monitored. Faecal blood loss and the reduction in haemoglobin levels were significantly less in the choline magnesium trisalicylate group than in the acetylsalicylic acid group. No significant differences were detected in the partial thromboplastin time, prothrombin time or bleeding time in either group.
D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000009:adverse effects*; D002794:Choline / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008551:Melena / Q000139:chemically induced*; D012459:Salicylates / Q000009:adverse effects*
D012459:Salicylates; C017959:choline magnesium trisalicylate; D002794:Choline; D001241:Aspirin