[Effect of a combined radiation lesion on the enzyme activity of the glutathione redox system of the rat liver].
A study was made of activity of glutathione peroxidase, glutathione reductase and glutathione-dehydroascorbate oxidoreductase in the rat liver under x-ray treatment in doses of 206 or 155 mC/kg coupled with mechanical injury (closed fracture of the leg bones). Radiation in a dose of 206 mC/kg gave rise to the following changes in activity of glutathione redox-system enzymes: reduced activity of glutathione peroxidase on the 3d day, and increased activity of glutathione reductase, and glutathione-dehydroascorbate oxidoreductase on the 7th day after combined radiation injury. Radiation in a dose of 155 mC/kg was accompanied by increased activity of glutathione-dehydroascorbate oxidoreductase on the 7th day and reduced glutathione reductase activity on the 30th day after the injury infliction.
D000818:Animals; D003683:Dehydroascorbic Acid / Q000378:metabolism; D005596:Fractures, Closed / Q000201:enzymology; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006614:Hindlimb / Q000293:injuries; D007869:Leg Injuries / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism; D011833:Radiation Injuries, Experimental / Q000201:enzymology*; D051381:Rats; D013997:Time Factors
D010088:Oxidoreductases; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; C020666:glutathione dehydrogenase (ascorbate); D005978:Glutathione; D003683:Dehydroascorbic Acid
Vliianie kombinirovannogo radiatsionnogo porazheniia na aktivnost' fermentov redoks-sistemy glutationa pecheni krys.