Two monoclonal antibodies (OKIa1 and OKT10) for the study of the final B cell maturation.
OKT10 is a monoclonal antibody which recognizes an antigenic structure of 45,000 daltons which is present on precursor T and B cells, activated T cells and some monocytes. In this study, this antibody was shown to react strongly with the surface membrane of plasma cells. In addition, OKT10 can be used to study final B cell maturation since the OKT10 antigen is expressed on mature lymphocytes and lymphoplasmacytic cells. Acquisition of OKT10 reactivity occurs in an inverse or opposite relationship to the presence of Ia-like antigenic expression. Therefore, these two antigens can be employed as complementary opposite reactants for the study of mature B cell malignancies, such as CLL, multiple myeloma, and Waldenström malignancy.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis; D007945:Leukemia, Lymphoid / Q000276:immunology; D009101:Multiple Myeloma / Q000276:immunology; D010950:Plasma Cells / Q000276:immunology / Q000648:ultrastructure; D011817:Rabbits; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D008258:Waldenstrom Macroglobulinemia / Q000276:immunology
D000911:Antibodies, Monoclonal; D007075:Immunoglobulin M; D011947:Receptors, Antigen, B-Cell