[Treatment of diabetic ketoacidosis in children].
Two groups of children with severe diabetic ketoacidosis were treated with 2 different insulin regimens: the first with conventional intermittent intramuscular insulin injections (0.5-1.0 U/kg/3-4 hrs), the second, with continuous low-dose insulin infusion (0.05-0.1 U/kg/hr). Therapeutic effects were compared. Compared to the conventional regimen, low-dose insulin infusion showed several advantages: 1) better control of blood glucose level, 2) no risk of hypoglycemia and hypokaliemia, 3) rapid decrease of urinary ketone bodies and 4) gradual acidosis correction. When associated with a proper replacement of fluids and electrolytes, low-dose insulin infusion appeared to be a simple and effective regimen in the treatment of children with diabetic ketoacidosis.
D000293:Adolescent; D001786:Blood Glucose; D002648:Child; D002675:Child, Preschool; D016883:Diabetic Ketoacidosis / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D007273:Injections, Intramuscular; D007328:Insulin / Q000008:administration & dosage*; D007332:Insulin Infusion Systems; D007657:Ketone Bodies / Q000652:urine; D008297:Male; D011188:Potassium / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D007657:Ketone Bodies; D011188:Potassium
Le traitement de l'acidocétose diabétique. Comparaison des résultats obtenus par insulinothérapie conventionnelle et perfusion continue de petites doses d'insuline.