[Effect of sulpiride and castration on mammary carcinogenesis caused by 7,12-dimethylbenzanthracene in the Wistar rat].
DMBA exerts strong oncogenic activity on the mammary tissue of female Wistar rats, inducing neoplasms in 74% of the animals exposed to it. Most of the tumors obtained in this way are of an epithelial nature, and show histological characteristics of malignancy. The castration of animals which have been administered DMBA drastically reduces the appearance of tumors, but does not totally eliminate them. The joint administration of Sulpiride and DMBA neither modifies the incidence of mammarian tumors nor their nature and histology with respect to the tumors obtained from the administration of DMBA alone. Sulpiride does not modify the DMBA tumoral induction in castrated rats. The Sulpiride itself cannot induce mammarian tumors in Wistar rats, according to the Huggins experimental model (production of mammarian tumors in Wistar rats by the administration of DMBA). The stimulating diencephalic action of the secretion of prolactin with Sulpiride is not tumorogenical in the experimental model investigated.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors*; D000230:Adenocarcinoma / Q000139:chemically induced; D000232:Adenofibroma / Q000139:chemically induced; D000818:Animals; D001551:Benz(a)Anthracenes / Q000037:antagonists & inhibitors*; D002369:Castration; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced* / Q000517:prevention & control; D051381:Rats; D011919:Rats, Inbred Strains; D013469:Sulpiride / Q000494:pharmacology*
D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene; D013469:Sulpiride
Efectos del sulpiride y castración sobre la carcinogenesis mamaria por el 7,12-dimetilbenzantraceno (DMBA) en la rata Wistar.