title: Derivatives of 1H-tetrahydrobenzodiazepine-1,5.
abstract: Synthesis of acyl derivatives of 2-aminomethylene-4-phenyl-1H-tetrahydrobenzodiazepine-1,5: compounds 5, 7 and 8, of a Schiff base 6 acids 9 and 10, and esters of aryl- or alkyl-1H-tetrahydro-1,5-benzodiazepine-2-carboxylic acids 11-14 is described. Compounds 9-13 showed potent antagonism towards pentetrazol, and compound 13 also potentiated the action of DOPA and had antiserotonin properties.
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004295:Dihydroxyphenylalanine / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000138:chemical synthesis
chemical_list: D000927:Anticonvulsants; D012702:Serotonin Antagonists; D001569:Benzodiazepines; D004295:Dihydroxyphenylalanine