Effects of nitroglycerin and ethylene glycol dinitrate mixture (blasting oil) on rat brain, liver and kidney.
Rats were injected intraperitoneally (150 mg/kg) with a mixture of nitroglycerin and ethylene glycol dinitrate (1:3). Treatment caused a transient small increase in methemoglobin contents in blood and diminished contents of reduced glutathione in liver and brain. Hepatic cytochrome P-450 concentration and ethoxycoumarin deethylase activity decreased shortly after exposure but later the effect disappeared. Succinate dehydrogenase activity decreased in liver, kidney and brain. In brain, activity of creatine kinase increased significantly and slight increase in hepatic UDPglucuronosyltransferase and epoxide hydrolase activity was observed. Renal ethoxycoumarin activity increased transiently. The results point to interaction of hydrolytically released nitrite with hemoproteins.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D003580:Cytochromes / Q000378:metabolism; D005026:Ethylene Glycols / Q000494:pharmacology*; D005107:Explosions; D005978:Glutathione / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D005996:Nitroglycerin / Q000494:pharmacology*; D051381:Rats
D003580:Cytochromes; D005026:Ethylene Glycols; C004882:ethylene glycol dinitrate; D005996:Nitroglycerin; D005978:Glutathione