Zomepirac-related acute renal failure.
A case of acute renal failure in a chronic acetaminophen abuser receiving concurrent zomepirac therapy is reported. Zomepirac may have enhanced the negative effects of acetaminophen on renal medullary blood flow, so that the two drugs together were more likely to cause renal failure than either drug alone.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D011758:Pyrroles / Q000009:adverse effects*; D014046:Tolmetin / Q000009:adverse effects* / Q000031:analogs & derivatives
D000893:Anti-Inflammatory Agents; D011758:Pyrroles; C020549:zomepirac; D014046:Tolmetin