[Protective effect of procyanidolic oligomers on the heterologous phase of glomerulonephritis induced by anti-glomerular basement membrane antibodies].
Treatment by procyanidolic oligomers can significantly decrease the proteinuria indiced in the Rat by intravenous injection of anti glomerular basement membranes antibodies. Immunohistological analysis shows that procyanidolic oligomers do not interfere with the mechanisms of immunopathological injury involved in this model (antibody binding to glomerular basement membrane, complement activation, glomerular influx of polymorphonuclear leucocytes). Their protective effect may be due to an increased resistance of the glomerular capillary to the inflammatory mediators released by neutrophils.
D000818:Animals; D000906:Antibodies; D001485:Basement Membrane / Q000276:immunology / Q000502:physiology*; D001578:Benzopyrans / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology*; D005921:Glomerulonephritis / Q000139:chemically induced / Q000503:physiopathology* / Q000517:prevention & control; D007678:Kidney Glomerulus / Q000276:immunology / Q000503:physiopathology*; D010936:Plant Extracts; D011692:Puromycin Aminonucleoside; D051381:Rats; D011919:Rats, Inbred Strains
D000906:Antibodies; D001578:Benzopyrans; D010936:Plant Extracts; D011692:Puromycin Aminonucleoside; D002392:Catechin
Effet protecteur des oligomères procyanidoliques sur la glomérulonéphrite par anticorps antimembrane basale glomérulaire à la phase hétérologue.