Pulmonic regurgitation due to valvular tophi.
Documented cardiac tophi are rare and have not previously been reported to cause clinically manifest valvular disease. A 31-year-old male with complex cyanotic congenital heart disease (Taussig-Bing anomaly) and secondary tophaceous gouty arthritis is described. Terminally, he presented with clinical evidence of a brain abscess and a new semilunar regurgitant murmur. Two-dimensional echocardiography suggested vegetative lesions as the cause of the murmur. The patient was treated for infective endocarditis. At autopsy, the cause of the semilunar regurgitant murmur was shown to be sterile tophi located along the line of pulmonary valvular coaptation. Tophaceous deposits were also present in the mitral valve.
D000328:Adult; D006073:Gout / Q000150:complications*; D006349:Heart Valve Diseases / Q000150:complications*; D006801:Humans; D008297:Male; D011664:Pulmonary Valve / Q000473:pathology; D011665:Pulmonary Valve Insufficiency / Q000209:etiology* / Q000473:pathology