Modification of human airway smooth muscle reactivity by drugs that interfere with arachidonic acid metabolism.
Histamine-induced contractions of small airways from human lung were substantially augmented by the cyclo-oxygenase inhibitor, indomethacin, whereas the contraction of larger airways was not. Mixed cyclo-oxygenase/lipoxygenase inhibitors of arachidonic acid metabolism did not modify histamine-induced contractions of smooth muscle from either small or large airways but completely reversed the augmentation of histamine responses produced by indomethacin on the smaller airways. The SRS-A (slow reacting substance of anaphylaxis) antagonist, FPL55712, did not affect the augmentation of histamine-induced contractions by indomethacin.
D000403:Airway Resistance / Q000187:drug effects*; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D001980:Bronchi / Q000187:drug effects; D002867:Chromones / Q000494:pharmacology; D004347:Drug Interactions; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D009130:Muscle, Smooth / Q000187:drug effects* / Q000378:metabolism; D013189:SRS-A / Q000494:pharmacology
D001095:Arachidonic Acids; D002867:Chromones; D013189:SRS-A; D016718:Arachidonic Acid; D006632:Histamine; C006312:FPL 55712; D007213:Indomethacin