title: Fetal and maternal cardiovascular effects of atropine and glycopyrrolate.
abstract: This study compared the effects of intravenous atropine and glycopyrrolate on maternal and fetal heart rates and variability, maternal blood pressure, and uterine activity in 20 normal full-term parturients in labor. Group 1 (N = 10) received 0.005 mg/kg of glycopyrrolate, and group 2 (N = 10) received 0.01 mg/kg of atropine. There were no statistically significant changes in fetal heart rates or variability in either group. Uterine activity increased in a normal manner as labor progressed. Maternal heart rate increased significantly and essentially equally in all patients in both groups ranging from 15 to 78 beats/min and a mean (+/- SD) of 36 +/- 16 in group 1 and from 15 to 65 beats/min with a mean of 35 +/- 17 in group 2. There were no statistically significant changes in maternal blood pressure in either group.
mesh_terms: D000328:Adult; D000773:Anesthesia, Obstetrical; D001285:Atropine / Q000494:pharmacology*; D002319:Cardiovascular System / Q000187:drug effects*; D005260:Female; D005318:Fetal Heart / Q000187:drug effects*; D006024:Glycopyrrolate / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D011247:Pregnancy; D011759:Pyrrolidines / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects
chemical_list: D011759:Pyrrolidines; D001285:Atropine; D006024:Glycopyrrolate