title: Endogenous pyrogen activity in human plasma after exercise.
abstract: Plasma obtained from human subjects after exercise and injected intraperitoneally into rats elevated rat rectal temperature and depressed plasma iron and zinc concentrations. The pyrogenic component was heat-denaturable and had an apparent molecular weight of 14,000 daltons. Human mononuclear leukocytes obtained after exercise and incubated in vitro released a factor into the medium that also elevated body temperature in rats and reduced trace metal concentrations. These results suggest that endogenous pyrogen, a protein mediator of fever and trace metal metabolism during infection, is released during exercise.
mesh_terms: D000328:Adult; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D006801:Humans; D007375:Interleukin-1; D007501:Iron / Q000097:blood; D007962:Leukocytes / Q000502:physiology; D008297:Male; D008970:Molecular Weight; D005082:Physical Exertion; D011506:Proteins / Q000502:physiology; D011749:Pyrogens / Q000097:blood / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000097:blood
chemical_list: D007375:Interleukin-1; D011506:Proteins; D011749:Pyrogens; C008270:leukocyte endogenous mediator; D007501:Iron; D015032:Zinc