Creatine kinase isoenzymes in severe head injury.
Brain-type creatine kinase (CK) isoenzyme (CK-BB) was found in the ventricular cerebrospinal fluid (CSF) and the serum in a series of 35 patients within 13 hours following severe head injury. There was a good correlation between total CK and CK-BB activities in CSF only. The values found in the CSF appear to be a quantitative index of brain dysfunction at admission, and did not correlate with intracranial pressure activity. High levels of CK-BB in the CSF correlated with a poor outcome, and thus offer a reliable criterion for the assessment of the severity of head injury.
D000293:Adolescent; D000328:Adult; D001930:Brain Injuries / Q000201:enzymology*; D002648:Child; D002675:Child, Preschool; D003128:Coma / Q000201:enzymology; D003402:Creatine Kinase / Q000097:blood / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D007223:Infant; D007427:Intracranial Pressure; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged
D007527:Isoenzymes; D003402:Creatine Kinase