Response of an abdominal aortic thrombotic occlusion to local low-dose streptokinase therapy.
Local low-dose streptokinase infusion (5000 to 6000 IU/hr) as compared to systemic streptokinase infusion (loading dose 250,000 IU/hr, maintenance dose 100,000 IU/hr) successfully relieved a total thrombotic abdominal aortic occlusion. No complications of bleeding or distal embolization occurred during streptokinase therapy, which required only 8 days of hospitalization. When seen at 4 months after streptokinase infusion, the patient was still free of symptoms. When no immediate threat of ischemic limb loss exists, streptokinase may offer a promising therapeutic alternative to surgical intervention for patients who represent a poor operative risk.
D001012:Aorta, Abdominal; D001018:Aortic Diseases / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D013300:Streptokinase / Q000008:administration & dosage* / Q000627:therapeutic use; D013927:Thrombosis / Q000188:drug therapy*
D006493:Heparin; D013300:Streptokinase