A comparison of high performance liquid chromatographic assays with the current pharmacopoeial assays for the combined formulation of ergometrine and oxytocin.
This paper reports the comparison of recently-developed chromatographic assays (using high performance liquid chromatography) with the present British Pharmacopoeial methods for the combined formulation of ergometrine and oxytocin. The estimates using high performance liquid chromatography were in good agreement with both the Pharmacopoeial determinations and nominal contents. The variability of estimates for ergometrine was similar for both procedures, whereas the variability of estimates of oxytocin content by chromatographic assay was significantly less than the variability of estimates by the Pharmacopoeial bioassay.
D001681:Biological Assay; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004338:Drug Combinations; D004874:Ergonovine / Q000032:analysis*; D010121:Oxytocin / Q000032:analysis*; D010602:Pharmacopoeias as Topic; D006113:United Kingdom
D004338:Drug Combinations; D010121:Oxytocin; D004874:Ergonovine