Carcinogenic metabolites of 5-methylchrysene.
Synthesis is described of trans-1,2-dihydroxy-1,2-dihydro-5-methylchrysene and trans-1,2-dihydroxy-anti-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene, implicated as the proximate and ultimate carcinogenic metabolites, respectively, of the potent environmental carcinogen 5-methylchrysene.
D002273:Carcinogens / Q000378:metabolism*; D002911:Chrysenes / Q000138:chemical synthesis* / Q000378:metabolism* / Q000633:toxicity; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
D002273:Carcinogens; D002911:Chrysenes; D007202:Indicators and Reagents; D010616:Phenanthrenes; C017229:1,2-dihydro-1,2-dihydroxy-5-methylchrysene; C037783:1,2-dihydroxy-epoxy-1,2,3,4-tetrahydro-5-methylchrysene; C008422:5-methylchrysene