Contact phase of blood coagulation in diabetes mellitus.
The first phase of the intrinsic coagulation system was studied in twenty-six diabetic outpatients. The parameters tested were kallicrein, prekallicrein, factor XI and factor XII activities. Kallicrein and factor XI showed significantly elevated activities as compared with a normal control group (P less than 0.05 and less than 0.001, respectively). Factor XI and factor XII levels were higher in non-insulin dependent than in insulin dependent diabetics. We found that the kallicrein-prekallicrein system was activated in our diabetic patients and that such activation could probably be secondary to lesions of the vascular endothelium present in long-term diabetics. No correlation was found between glycaemia and activity levels of this system. Our data represent another demonstration of the existence of a hypercoagulable state in diabetes mellitus.
D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D003920:Diabetes Mellitus / Q000097:blood*; D005172:Factor XI / Q000378:metabolism; D005174:Factor XII / Q000378:metabolism; D005260:Female; D006801:Humans; D007610:Kallikreins / Q000097:blood; D008297:Male; D008875:Middle Aged; D011288:Prekallikrein / Q000502:physiology
D005174:Factor XII; D005172:Factor XI; D011288:Prekallikrein; D007610:Kallikreins