[Changes in various hemostasis indices during transient coronary insufficiency with different durations of myocardial ischemia].
Experiments on 93 white random-bred male rats weighing 200 +/- 10 g have shown that during myocardial ischemia under transitory coronary insufficiency, there is an increase in platelet adhesive capacity, acceleration of fibrinogenesis, staged time course of formation of the fibrin-platelet structure of the blood clot, depression of its velocity and lysis degree, as well as of fibrin polymerization. Postischemic reperfusion of the coronary blood flow is not followed by normalization of all the hemostatic indicators under study even after a short-term (10 min) myocardial ischemia. Reperfusion after a long-term (40 min) ischemia gives rise to depression of coagulation and fibrinolytic activity, while that after a still longer ischemia (120 min) is characterized by discordant changes in the parameters of the systems indicated. It is assumed that similar shifts in hemostasis can be observed in patients with different patterns of coronary insufficiency.
D000818:Animals; D003018:Clot Retraction; D003326:Coronary Circulation; D003327:Coronary Disease / Q000097:blood*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005342:Fibrinolysis; D006487:Hemostasis; D008297:Male; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D051381:Rats; D013997:Time Factors
D005338:Fibrin Fibrinogen Degradation Products
Osobennosti dinamiki nekotorykh pokazateleĭ gemostaza pri transitornoĭ koronarnoĭ nedastatochnosti s razlichnoĭ dlitel'nost'iu perioda ishemii miokarda.