Lack of nocturnal prolactin increase in patients with hypogonadotropic hypogonadism.
The circadian prolactin rhythm was studied in a group of 16 male adult volunteers: 10 healthy subjects and 6 patients affected by isolated hypogonadotropic hypogonadism (IHH). A significant nycto-hemeral prolactin rhythm (p = 0.0003, according to cosinor method) is detected in healthy subjects, but not in patients with IHH. In view of these results we may deem that the absence of nycto-hemeral variations of serum prolactin in subjects with IHH could be caused by failure of LH and FSH release.
D000328:Adult; D002940:Circadian Rhythm; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006801:Humans; D007006:Hypogonadism / Q000503:physiopathology*; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D008954:Models, Biological; D011388:Prolactin / Q000378:metabolism*; D012016:Reference Values
D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone