title: Elimination of adverse effects of ethoxyquin (EQ) by methionine hydroxy analog (MHA). Protective effects of EQ and MHA for bitterweed poisoning in sheep.
abstract: Dietary ethoxyquin (EQ) and methionine hydroxy analog (MHA) protected 6-8-month-old wethers from toxic doses of bitterweed (Hymenoxys odorata DC.). The EQ-MHA group received sweet feed (corn, oats, dehydrated alfalfa pellets, cane molasses and minerals), 500 g/day/sheep, supplemented with EQ and MHA (0.5% and 1.0% of feed, respectively) for 9 days prior to the poisoning with bitterweed while the MHA group received the same feed without EQ and controls received the same amount of feed with no additives. Two of 6 MHA-treated and 3 of 7 controls died whereas all 7 EQ-MHA-treated sheep survived after receiving 5 doses of bitterweed (5 X 5.5 g/kg) in 6 days. Coadministration of MHA and EQ eliminated the adverse effect of EQ; dietary EQ lowered the serum albumin, calcium, and alkaline phosphatase content while protecting the animals from bitterweed poisoning. EQ is the most promising protective agent tested for bitterweed poisoning in sheep.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005015:Ethoxyquin / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008715:Methionine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010939:Plant Poisoning / Q000517:prevention & control / Q000662:veterinary*; D011804:Quinolines / Q000627:therapeutic use*; D012756:Sheep; D012757:Sheep Diseases / Q000517:prevention & control*
chemical_list: D004338:Drug Combinations; D011804:Quinolines; C008391:alpha-hydroxy-gamma-methylmercaptobutyric acid; D005015:Ethoxyquin; D008715:Methionine