Effect of the benzodiazepine receptor antagonist Ro 15-1788 on the anticonvulsant and anticonflict actions of MK-801.
MK-801, phenobarbital and clonazepam blocked convulsions elicited in mice by bicuculline. Treatment with Ro 15-1788 antagonized the anticonvulsant action of clonazepam, but not MK-801 or phenobarbital. The anticonflict effect in the rat of chlordiazepoxide, but not MK-801, was antagonized by Ro 15-1788. Despite having certain benzodiazepine-like effects in vivo, MK-801 does not act directly or indirectly via receptors for benzodiazepines.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001570:Benzodiazepinones / Q000494:pharmacology*; D001640:Bicuculline / Q000494:pharmacology; D002707:Chlordiazepoxide / Q000494:pharmacology; D002998:Clonazepam / Q000494:pharmacology; D003220:Conflict, Psychological; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D016291:Dizocilpine Maleate; D004347:Drug Interactions; D005260:Female; D005442:Flumazenil; D051379:Mice; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000927:Anticonvulsants; D001570:Benzodiazepinones; D003986:Dibenzocycloheptenes; D005442:Flumazenil; D002998:Clonazepam; D016291:Dizocilpine Maleate; D002707:Chlordiazepoxide; D001640:Bicuculline; D010634:Phenobarbital