[Reduction of platelet serotonin in major depression (endogenous depression)].
Serum serotonin (5-HT) levels were measured in several patients with psychiatric disorders using high pressure liquid chromatography with electrochemical detection. A marked reduction in 5-HT levels was found in male and female patients with major depressive disorder, as compared to controls, but not in dysthymic disorder. These modifications may constitute biochemical changes suggestive of major depressive disorders; they could not be attributed to chronic antidepressant treatment.
D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003866:Depressive Disorder / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010259:Paranoid Disorders / Q000097:blood; D012016:Reference Values; D012559:Schizophrenia / Q000097:blood; D012701:Serotonin / Q000097:blood*; D012737:Sex Factors
D012701:Serotonin
Diminution de la sérotonine plaquettaire dans la dépression majeure (dépression endogène).