Anterior optic pathways gliomas. The dilemma of treatment.
Anterior optic pathways gliomas are classifiable histologically and clinically with other pilocytic gliomas of the midline (of hypothalamus and brainstem), especially of childhood. The very slow course, sometimes imperceptible over the years, that characterizes the majority of them should not be taken to mean lack of growth. Tumultuous courses and acute episodic deteriorations are both possible. Hence the need for therapy. Indefinite abstention cannot be upheld, at least in the great majority of cases. In gliomas of a nerve only the object of surgery is usually removal, using the intraorbital, intracanalicular and intracranial approaches, but in gliomas of the chiasm or chiasm-hypothalamus the object is more exploratory and decompressive. Radiotherapy is generally accepted as affective only in the latter cases. No single standard protocol is possible: treatment had to be individualized case by case.
D000328:Adult; D001254:Astrocytoma / Q000601:surgery; D002648:Child; D003390:Cranial Nerve Neoplasms / Q000601:surgery*; D005094:Exophthalmos / Q000601:surgery; D005500:Follow-Up Studies; D005910:Glioma / Q000601:surgery*; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000601:surgery; D009456:Neurofibromatosis 1 / Q000601:surgery; D009897:Optic Chiasm / Q000601:surgery*; D009901:Optic Nerve Diseases / Q000601:surgery*; D011879:Radiotherapy Dosage; D014792:Visual Acuity / Q000528:radiation effects; D014794:Visual Fields / Q000528:radiation effects