[Changes in the primary structure of DNA in rat organs during the aging process].
Thin-layer chromatography was used to study the composition of bases and pyrimidine sequences of varying lengths (isopliths) in DNA of different organs of rats aged 1, 12 and 30 months. It was found that with age the isoplith composition of DNA in the organs under study changed towards the chaotic distribution. The composition of DNA bases changed with age towards enrichment with guanine-cytosine-vapors, which was particularly pronounced in organs marked by an age-related decrease of 5-methylcytosine in DNA.
D000375:Aging; D000595:Amino Acid Sequence; D000818:Animals; D002855:Chromatography, Thin Layer; D004247:DNA / Q000032:analysis*; D009928:Organ Specificity; D011742:Pyrimidine Nucleotides / Q000032:analysis; D051381:Rats; D013056:Spectrophotometry, Ultraviolet
D011742:Pyrimidine Nucleotides; D004247:DNA
Izmenenie pervichnoĭ struktury DNK nekotorykh organov krys v protsesse stareniia.