Adenine-induced hypoxanthine release from IMP-enriched human erythrocytes.
Adenine uptake and hypoxanthine release by IMP-enriched human erythrocytes has been studied. The presence of IMP within the erythrocytes leads to an increase in the rate of adenine incorporation. Adenine is taken up by IMP-enriched erythrocytes as AMP, even when intracellular 5-phosphoribosyl-1-pyrophosphate concentration is undetectable and too low to allow IMP synthesis from hypoxanthine. During adenine uptake and AMP synthesis, hypoxanthine is released by the cells. The possibility that 5-phosphoribosyl-1-pyrophosphate, necessary for AMP synthesis, is formed through the hypoxanthine guanine phosphoribosyltransferase-catalyzed IMP pyrophosphorolysis is considered.
D000225:Adenine / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007042:Hypoxanthines / Q000097:blood*; D007291:Inosine Monophosphate / Q000097:blood*; D007292:Inosine Nucleotides / Q000097:blood*
D007042:Hypoxanthines; D007292:Inosine Nucleotides; D007291:Inosine Monophosphate; D000225:Adenine