[Morphologic and biochemical characterization of the Islets of Langerhans of C57BL/KsJ-mice treated with glibenclamid and glucose].
From the findings of our investigations can be concluded that after long-lasting in vivo gifts of glibenclamid and glucose a decrease of the glucose-induced secretion of insulin in the B-cells of the islets of Langerhans is resulting. After strong experimental stimulation during the existence of an abnormal metabolic situation the synthesis of insulin had not been disturbed and there were also no clear signs of exhaustion of the activity in the islets. Probably, biosynthesis of insulin is coming off only more quickly and is inducing a reduction of insulin already in the cell itself (according to the increased occurrence of lysosomes). The changed production of insulin which can be detected biochemically is, in some conditions, resulting from a temporally disturbance of the mechanism of secretion in the B-cells.
D000818:Animals; D005947:Glucose / Q000494:pharmacology*; D005905:Glyburide / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000648:ultrastructure*; D051379:Mice; D008810:Mice, Inbred C57BL
D007328:Insulin; D005947:Glucose; D005905:Glyburide
Zur morphologischen und biochemischen Charakterisierung der Langerhansschen Inseln von mit Glibenclamid und Glukose belasteten C57BL/KsJ-Mäusen.