Effect of hydrostatic pressure on halothane-induced depression of mitochondrial respiration.
Anesthetized animals are awakened when subjected to increased atmospheric pressure. Whether all phenomena associated with the anesthetic state are similarly reversed is not known. Since the anesthetic halothane produces a dose-related reversible depression of rat liver mitochondrial respiration, the effect of 51 atmospheres of pressure on the drug's action was evaluated. It is concluded that application of pressure does not antagonize the inhibition produced by this anesthetic.
D000818:Animals; D001274:Atmospheric Pressure; D004305:Dose-Response Relationship, Drug; D006221:Halothane / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats
D006221:Halothane