Important of HLA matching in cadaveric renal transplantation. A prospective one-center study.
Matching for the HLA-A and -B antigens was found to have a significant influence on the outcome of 459 cadaveric first transplants, with a difference in graft survival of 21% at one year between best and worst matched grafts (p = 0.003). Matching for the HLA-DR antigens seemed to have an even greater influence. In a material of 226 prospectively typed transplants, a difference in graft survival of 35% at one year between best and worst matched transplants was found (p = 0.03). In the HLA-DR matched transplants there was no significant effect of matching for the HLA-A and -B antigens. An effect of pre-transplant blood transfusions was possibly seen only in DR mismatched transplants, but the effect was not statistically significant. The results indicate that major emphasis should be placed on obtaining HLA-DR compatibility in renal transplantation.
D000328:Adult; D001803:Blood Transfusion; D002102:Cadaver; D005802:Genes, MHC Class II; D006085:Graft Survival; D006680:HLA Antigens / Q000032:analysis / Q000235:genetics / Q000276:immunology; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation; D011300:Preoperative Care; D011446:Prospective Studies
D006680:HLA Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II