Changes in free amino acid contents of rat brain induced by exposure to methyl bromide.
Rats were exposed to methyl bromide (MB) for 24 h at 10-120 ppm or for 3 weeks at 1-10 ppm. Changes in free amino acid contents of rat midbrain were measured by high-performance liquid chromatography (HPLC). MB increased glutamine and aspartic acid contents dose-dependently by short-and long-term exposure. Alanine content was markedly increased by long-term exposure to 10 ppm MB. Glycine was dose-dependently increased, except at 120 ppm. The harmful effect of MB on the central nervous system is discussed in relation to the changes in amino acid metabolism.
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001273:Atmosphere Exposure Chambers; D001923:Brain Chemistry / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D006842:Hydrocarbons, Brominated / Q000494:pharmacology*; D008297:Male; D051381:Rats
D000596:Amino Acids; D006842:Hydrocarbons, Brominated; C005218:methyl bromide