title: Porokeratosis (Mibelli): treatment with topical 5-fluorouracil.
abstract: The case history of a patient with a solitary classic porokeratosis (Mibelli) on the hand is described. The lesion cleared without scarring with the use of topical 5-fluorouracil until a strong dermatitis was elicited, thus avoiding surgery and attendant restriction of function. No sign of recurrence developed in the following 2 years. The potential for malignant change in porokeratosis (Mibelli) and its resistance to topical treatment as documented in the literature are also reviewed.
mesh_terms: D000287:Administration, Topical; D000328:Adult; D005472:Fluorouracil / Q000008:administration & dosage*; D006229:Hand Dermatoses / Q000188:drug therapy; D006801:Humans; D007642:Keratosis / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D012867:Skin / Q000473:pathology; D013577:Syndrome
chemical_list: D005472:Fluorouracil