title: Induction of sex-linked recessive lethal mutations in Drosophila melanogaster males by gaseous 1,2-dibromo-3-chloropropane (DBCP).
abstract: Acute exposure to gaseous 1,2-dibromo-3-chloropropane (DBCP) caused sex-linked recessive lethal mutations in Drosophila melanogaster males. Brood pattern analysis showed that spermatids and spermatocytes were more sensitive to the lethal-mutation induction by DBCP than were spermatogonia. The mutation induction was not observed in the stage of spermatozoa.
mesh_terms: D000818:Animals; D003433:Crosses, Genetic; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics*; D005260:Female; D005804:Genes, Lethal / Q000187:drug effects*; D005808:Genes, Recessive / Q000187:drug effects*; D007306:Insecticides / Q000494:pharmacology*; D008297:Male; D009154:Mutation; D011407:Propane / Q000031:analogs & derivatives* / Q000494:pharmacology; D013087:Spermatids / Q000187:drug effects; D013090:Spermatocytes / Q000187:drug effects; D013093:Spermatogonia / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects*
chemical_list: D007306:Insecticides; C007318:1,2-dibromo-3-chloropropane; D011407:Propane