Hypoxic and embolic pulmonary vasoconstriction.
In-vitro studies of helically-cut segmental pulmonary artery strips from 43 patients undergoing thoracic surgery were performed. Cumulative dose-response contraction curves were elicited, mean maximum contraction was significantly greater from histamine (Hist) than from prostaglandin F2 alpha (PGF2 alpha), serotonin (5-HT), angiotensin II (A II) or noradrenaline (NA). Hist and PGF2 alpha showed significantly lower values for ED50 than NA, 5-HT and A II. Anoxia did not constrict the isolated arteries.
D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011651:Pulmonary Artery / Q000187:drug effects; D011655:Pulmonary Embolism / Q000503:physiopathology*; D014661:Vasoconstriction / Q000187:drug effects