[Effect of nootropic drugs on the dopamine release and dopamine uptake in structures of the rat striatum].
Nootropics increase the overflow of dopamine from rat striatum slices in a concentration dependent manner, but without relation to their clinical effectiveness. The influence of a nootropic drugs and of amphetamine on the stimulus induced dopamine release points to a relationship between nootropic and nooanaleptic activity, on the one hand, and transmitter release, on the other. Dopamine re-uptake is not altered by nootropics like piracetam.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D004088:Dihydroergotoxine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D004347:Drug Interactions; D002504:Meclofenoxate / Q000494:pharmacology; D008536:Meglumine / Q000031:analogs & derivatives / Q000494:pharmacology; D009963:Orotic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011746:Pyrithioxin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D011619:Psychotropic Drugs; D004088:Dihydroergotoxine; C022100:methylglucamine orotate; D009963:Orotic Acid; D008536:Meglumine; D011746:Pyrithioxin; D002504:Meclofenoxate; D004298:Dopamine; D010889:Piracetam
Einfluss von Nootropika auf die Dopaminfreisetzung und Dopaminaufnahme in Strukturen des Rattenstriatum.