title: Rate of DNA synthesis in mammalian cells irradiated with ultraviolet light: a model based on the variations in the rate of movement of the replication fork and in the number of active replicons.
abstract: A model is proposed to describe the rate of DNA synthesis observed under certain conditions in UV irradiated mammalian cells. It is assumed that shortly after irradiation the rate of DNA synthesis drops mainly as a consequence of the drop in the rate of movement of the replication fork. This in turn, is due to a pause at the dimer for a limited length of time. Later on, a recovery in the rate of DNA synthesis occurs, and it is proposed that one of the parameters contributing to that is an increase in the number of active replicons. This simple model enables one to predict variations in the rate of DNA synthesis as a function both of UV dose and of time after irradiation.
mesh_terms: D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D004261:DNA Replication / Q000528:radiation effects*; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D011740:Pyrimidine Dimers; D011829:Radiation Dosage; D012093:Replicon / Q000528:radiation effects; D013997:Time Factors; D014466:Ultraviolet Rays
chemical_list: D011740:Pyrimidine Dimers; D004247:DNA