Site of expression of immunity to Naegleria fowleri in immunized mice.
An experiment was performed which confirmed a previous finding that mice are protected against Naegleria fowleri infection by immunization with amoeba-free supernatant from amoeba cultures. Histological observations suggested that this protection is expressed mainly at the nasal mucosa and possibly results from the combined effects of polymorphonuclear leucocyte-mediated killing of the amoeba and mechanical elimination of the organisms by extensive shedding of necrotic epithelium.
D000562:Amebiasis / Q000276:immunology* / Q000469:parasitology; D000656:Amoeba / Q000254:growth & development / Q000276:immunology*; D000818:Animals; D001921:Brain / Q000469:parasitology; D007114:Immunization; D007249:Inflammation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009297:Nasal Mucosa / Q000276:immunology* / Q000469:parasitology; D009504:Neutrophils