Pentasomy 21 characterizing spontaneously regressing congenital acute leukemia.
Pentasomy 21 was found to characterize the proliferating cells in a case of transient congenital acute leukemia (or congenital acute leukemia) with spontaneous remission. The patient was phenotypically normal, and cytogenetically no evidence could be found for the existence of a mosaic with a normal cell line and one with more than two No 21 chromosomes. The importance of these findings is discussed.
D000208:Acute Disease; D002904:Chromosomes, Human, 21-22 and Y; D006801:Humans; D007231:Infant, Newborn; D007938:Leukemia / Q000151:congenital* / Q000235:genetics; D007955:Leukemoid Reaction / Q000235:genetics; D008297:Male; D009365:Neoplasm Regression, Spontaneous; D011123:Polyploidy