title: Continuous intravenous anesthesia with etomidate for carbon dioxide laser surgery of the larynx.
abstract: Twenty-five adult patients undergoing carbon dioxide laser surgery for benign and malignant disease of the larynx were given continuous infusion of etomidate at 60 micrograms . kg-1 . min-1 for induction of anesthesia. Maintenance anesthesia was continued using one of three infusion rates: 20 micrograms . kg-1 . min-1 (n = 5), 30 micrograms . kg-1 . min-1 (n = 10), and 40 micrograms . kg-1 . min-1 (n = 10) of etomidate in air-oxygen mixture. Muscular relaxation was achieved by continuous infusion of succinylcholine, and fentanyl was used for analgesia. Continuous etomidate infusion for induction of anesthesia resulted in a significant decrease in the incidence of pain along the injection site to 8% and involuntary muscular movements to 12% compared with 35% and 44%, respectively, in a group of 25 adult patients undergoing endoscopic procedure who received intravenously a single volus injection of etomidate (0.3 mg .g kg-1). However, a prolonged recovery time was observed after 30 minutes of continuous etomidate infusion.
mesh_terms: D000293:Adolescent; D000328:Adult; D000771:Anesthesia, Intravenous; D002245:Carbon Dioxide; D004945:Esophagoscopy; D005045:Etomidate / Q000008:administration & dosage*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage*; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007828:Laryngoscopy; D007830:Larynx / Q000601:surgery*; D053685:Laser Therapy; D008875:Middle Aged; D014827:Vocal Cords / Q000601:surgery
chemical_list: D007093:Imidazoles; D002245:Carbon Dioxide; D005045:Etomidate