Modulation of phospholipase A activity in psoriatic skin.
The activity of phospholipase A2 was tested both in rat skin and human psoriatic skin before and after systemic treatment with a retinoic acid derivative: RO 10-9359. An increase of activity was found in the rat skin homogenates when the animals were treated with 3 mg/kg/day of the drug for 8 days, while no effect was found following treatment with 1.5 mg/kg/day for 10 days. On the contrary a decrease of this activity was found in homogenates from both involved and uninvolved skin of psoriatic patients after systemic treatment with 1-1.5 mg/kg/day for 10 days. These different results are discussed also in the light of the clinical effect of RO 10-9359 on psoriasis.
D000328:Adult; D000368:Aged; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D005050:Etretinate / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000201:enzymology; D010740:Phospholipases / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D011565:Psoriasis / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000201:enzymology*; D014212:Tretinoin / Q000031:analogs & derivatives*
D001095:Arachidonic Acids; D016718:Arachidonic Acid; D014212:Tretinoin; D005050:Etretinate; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2