Effect of acute and subacute treatment of clonidine on blood pH, PCO2 and PO2 in mice.
1. Measurements were made on blood pH, PCO2 and PO2 in mice after a single injection and following five weeks continuous clonidine hydrochloride treatment. 2. A single injection of clonidine hydrochloride exerts no effect on blood pH, PCO2 and PO2 but five weeks of continuous clonidine hydrochloride treatment lowers the blood pH and PCO2 and raises blood PO2, suggesting acidosis has taken place. 3. The acidosis may be attributed to rebound hypertension as a result of withdrawal of clonidine treatment.
D000818:Animals; D001769:Blood / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D003000:Clonidine / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D051379:Mice; D010100:Oxygen / Q000097:blood; D013997:Time Factors
D002245:Carbon Dioxide; D003000:Clonidine; D010100:Oxygen