Effects of weight loss on the dexamethasone suppression test.
The authors studied postdexamethasone cortisol secretion in 18 depression-free, healthy, obese subjects before and after weight loss. Although all subjects suppressed cortisol normally before weight loss, 5 of 18 (27.5%) failed to suppress cortisol after an average loss of 13.5 kg. This failure to suppress cortisol was not associated with any change in depression ratings.
D001835:Body Weight; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis / Q000523:psychology; D003907:Dexamethasone; D005189:False Positive Reactions; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D009765:Obesity / Q000178:diet therapy; D010555:Personality Inventory; D011569:Psychiatric Status Rating Scales
D003907:Dexamethasone; D006854:Hydrocortisone