Influence of 2 Br-alpha-ergocryptine (CB 154) on the secretion of prolactin, LH, FSH and testosterone and on testicular growth in rams subjected to different photoperiods.
The influence of 2-Br-alpha-ergocryptine (CB 154) on the secretion of gonadotrophins and on testicular function has been studied in rams subjected to either a normal photoperiod or an abnormal photoperiod causing hyperprolactinaemia. The CB 154 treatment significantly lowered the mean frequency of LH and testosterone pulses in hyperprolactinaemic animals as compared to solvent-treated ones. Also, only those groups subjected to an abnormal photoperiod (groups 2 and 3) exhibited a significant rise in the frequency of LH and testosterone peaks after CB 154 was withdrawn. During treatment, plasma FSH concentrations increased significantly only in group 1 which was subjected to normal photoperiodic variations. Testicular growth was delayed in CB 154-treated rams compared to solvent-treated ones only in group 3 (hyperprolactinaemic).
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006065:Gonadotropins, Pituitary / Q000378:metabolism*; D008027:Light; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D010507:Periodicity; D011388:Prolactin / Q000097:blood; D012756:Sheep / Q000502:physiology*; D013737:Testis / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D013739:Testosterone / Q000378:metabolism
D006065:Gonadotropins, Pituitary; D001971:Bromocriptine; D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone