Changes of gaseous exchange in the lungs of mice exposed to nitrogen dioxide and their recovery process.
To elucidate the accurate effects of NO2 on gaseous exchange in the lungs of mice during and after NO2 exposure, O2 and CO2 concentrations in the respiratory gas and respiratory rate (RR) were measured using the head-enclosed method, and arterial blood pHa, Paco2 and Pao2, lung wet weight, and lung water content were also examined. The results of the present study indicate that the gaseous exchange in the lungs of mice exposed to 20 ppm NO2 was acutely inhibited during NO2 exposure from the 3rd to 24th h, but it recovered functionally to the control level on the 3rd day after NO2 exposure.
D000818:Animals; D001834:Body Water / Q000378:metabolism; D002245:Carbon Dioxide / Q000097:blood; D006863:Hydrogen-Ion Concentration; D008168:Lung / Q000187:drug effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009585:Nitrogen Dioxide / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D010100:Oxygen / Q000097:blood; D011659:Pulmonary Gas Exchange / Q000187:drug effects*
D002245:Carbon Dioxide; D009585:Nitrogen Dioxide; D010100:Oxygen