title: Formation of ethane in vitro by rat liver homogenates following glutathione depletion in vivo.
abstract: Depletion of hepatic glutathione (GSH) in rats by treatment with phorone (diisopropylidene acetone) in vivo led to a dramatic enhancement of spontaneous ethane production by liver post-mitochondrial fractions. Exogenous GSH added in vitro abolished this effect in a concentration-dependent manner. The same inhibitory action was seen with both dithiocarb or (+)-catechin. The concentrations yielding 50% inhibition (I50) were in the micromolar range for all three compounds.
mesh_terms: D000818:Animals; D002392:Catechin / Q000494:pharmacology; D004980:Ethane / Q000378:metabolism*; D005978:Glutathione / Q000502:physiology*; D066298:In Vitro Techniques; D007659:Ketones / Q000494:pharmacology; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007659:Ketones; D008054:Lipid Peroxides; C018637:phorone; D002392:Catechin; D005978:Glutathione; D004980:Ethane