[Use of corticotherapy for the prevention of "radiation sickness" in patients subjected to cesium therapy for gynecologic neoplasms].
193 patients treated at Genoa University's Obstetrics and Gynaecology Clinic for uterine and vaginal neoplasias by remote after-loading caesiotherapy have been studied. 100 patients were given 6-alpha-methylprednisolone hemisuccinate, a corticosteroid derivative, against "radiation disease". Only one patient had to interrupt the treatment as a result of side-effects of the drug and none of the patients showed ill effects traceable to ionising radiation, in contrast with those who only received caesiotherapy (22 out of 93 cases). Given the efficiency and special tolerance of this cortisone derivative, it would appear to be of practical use in the prophylaxis of radiation induced diseases in general.
D000230:Adenocarcinoma / Q000532:radiotherapy*; D002277:Carcinoma / Q000532:radiotherapy*; D002588:Cesium Radioisotopes / Q000009:adverse effects*; D005260:Female; D005833:Genital Neoplasms, Female / Q000532:radiotherapy*; D006801:Humans; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011832:Radiation Injuries / Q000209:etiology / Q000517:prevention & control*; D014594:Uterine Neoplasms / Q000532:radiotherapy; D014625:Vaginal Neoplasms / Q000532:radiotherapy
D002588:Cesium Radioisotopes; D011239:Prednisolone; C021322:prednisolone hemisuccinate
L'impiego della corticoterapia come profilassi del "male da raggi" in pazienti sottoposte a cesioterapia per neoplasie ginecologiche.