Bioavailability of paediatric mixtures containing phenoxymethylpenicillin calcium or potassium salt.
The bioavailability of the calcium and potassium salts of phenoxymethyl-penicillin (dose 38,000 I.U./kg) was investigated in eight healthy adult volunteers. Administration of the calcium salt as an aqueous oral mixture resulted in a mean peak plasma concentration of 8.52 mg/l (SD 1 X 96) and that of the potassium salt mixture in a concentration of 8.40 mg/ml (SD 2.61), p greater than 0.1. The median time-to-peak levels were 0.75 h and 1.0 h, respectively (p greater than 0.1). The mean AUC for the calcium salt mixture was 16.94 mg X h/l (SD 3.31) and for the potassium salt 15.84 mg X h/l (SD 4.76), p less than 0.09. These findings confirm that an aqueous mixture of calcium phenoxymethylpenicillin is equivalent to a mixture of potassium phenoxymethylpenicillin.
D000328:Adult; D001682:Biological Availability; D002648:Child; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D010404:Penicillin V / Q000008:administration & dosage / Q000378:metabolism*; D011188:Potassium / Q000008:administration & dosage / Q000378:metabolism; D012964:Sodium / Q000008:administration & dosage / Q000378:metabolism; D013329:Structure-Activity Relationship
D012964:Sodium; D011188:Potassium; D010404:Penicillin V