Susceptibility of aldehyde and aldose reductases of human tissues to aldose reductase inhibitors.
The effect of aldose reductase inhibitors such as sorbinil, alrestatin, and quercitrin has been studied on the aldose reductase purified from human brain and lens, and aldehyde reductase I purified from human liver, and aldehyde reductase II purified from human brain, liver, and red cells. None of the aldose reductase inhibitors have been found to be specific for aldose reductase. Fifty micromolar sorbinil besides inhibiting aldose reductase, completely inhibits aldehyde reductase II from the brain, liver and red cells. Similarly, alrestatin and quercitrin also are potent inhibitors of aldehyde reductase I and aldehyde reductase II.
D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors*; D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D001921:Brain / Q000201:enzymology*; D002386:Cataract / Q000503:physiopathology; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D048289:Imidazolidines; D007546:Isoquinolines / Q000494:pharmacology; D007908:Lens, Crystalline / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D011794:Quercetin / Q000031:analogs & derivatives / Q000494:pharmacology; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*
D007093:Imidazoles; D048289:Imidazolidines; D007546:Isoquinolines; C012526:quercitrin; C016212:alrestatin; D011794:Quercetin; D000429:Alcohol Oxidoreductases; D013401:Sugar Alcohol Dehydrogenases; C019642:alcohol dehydrogenase (NADP+); D000449:Aldehyde Reductase; C026411:sorbinil