Plasma LH, FSH and TSH responses to the synthetic enkephalin analog (FK 33-824) in normal subjects and patients with pituitary diseases.
D-Ala, Mephe, Met, enkephalin (Sandoz FK 33-824), 1.0 or 0.5 mg, was administered by i.v. infusion to normal subjects, patients with acromegaly and hyperprolactinemia due to pituitary adenoma and patients with pituitary dwarfism. FK 33-824 induced no significant change in plasma level of LH, FSH or TSH in any of the subjects studied. These results suggest a lesser role of opioid regulation in the release of above pituitary hormones compared with that in GH, PRL and cortisol.
D000172:Acromegaly / Q000097:blood; D000236:Adenoma / Q000097:blood; D000293:Adolescent; D000328:Adult; D002648:Child; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; D004393:Dwarfism, Pituitary / Q000097:blood; D004723:Endorphins / Q000494:pharmacology*; D004745:Enkephalins / Q000494:pharmacology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010900:Pituitary Diseases / Q000097:blood*; D010911:Pituitary Neoplasms / Q000097:blood; D011388:Prolactin / Q000097:blood; D013972:Thyrotropin / Q000097:blood*
D004723:Endorphins; D004745:Enkephalins; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin