Sensitivity of the oxyntic and peptic cells to pentagastrin in duodenal ulcer patients and healthy subjects with similar secretory capacity.
The acid and pepsin responses to increasing doses of i.v. pentagastrin (0.01, 0.02, 0.1, 2.0 and 8.0 micrograms X kg-1 X h-1) were determined by gastric aspiration in 15 male duodenal ulcer (DU) patients and 11 male age-matched healthy controls (C). The lowest dose was infused for 60 min, the doses were then increased every 45 min. The stomach was continuously perfused with saline. Phenol red as marker showed an average loss of 8.4 +/- 1.4% in the DU and 10.0 +/- 1.4% in the C. Basal acid secretion and the dose-response (DR) curve for acid output (corrected for basal) did not differ for DU and C. The dose (D50) producing half the observed maximal acid response (MR), the calculated MR and calculated D50 was the same in DU and C. Similar results were obtained for pepsin secretion. The ratio of pepsin to acid secretion did not differ for DU and C. It is concluded that the sensitivity of the oxyntic as well as the peptic cells do not differ in DU and C with similar secretory capacity.
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004381:Duodenal Ulcer / Q000473:pathology / Q000503:physiopathology*; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010418:Pentagastrin / Q000494:pharmacology / Q000502:physiology*; D010434:Pepsin A / Q000378:metabolism
D010434:Pepsin A; D010418:Pentagastrin