The pituitary-testicular axis of uraemic subjects on haemodialysis and continuous ambulatory peritoneal dialysis.
Pituitary-testicular function was evaluated in 18 patients with chronic renal failure, 9 treated by maintenance haemodialysis (HD) and 9 by continuous ambulatory peritoneal dialysis (CAPD), and compared with a non-uraemic control group. Serum total testosterone and the free testosterone index were significantly low in both dialysis groups. Basal FSH and LH levels were elevated but this reached significance only with regard to LH. The responses of both FSH and LH to the iv administration of LRH were normal. There was no significant difference between the CAPD and HD groups in any of the hormonal parameters estimated. While CAPD may improve control of some metabolic parameters when compared with HD, it does not improve the function of the pituitary-testicular axis.
D000328:Adult; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000032:analysis; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010902:Pituitary Gland / Q000502:physiology*; D006435:Renal Dialysis; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013737:Testis / Q000502:physiology*; D013739:Testosterone / Q000097:blood
D012738:Sex Hormone-Binding Globulin; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone