title: The role of hypersensitivity reactions to toxoplasma antigens in experimental ocular toxoplasmosis in nonhuman primates.
abstract: To assess the role of ocular hypersensitivity reactions to Toxoplasma antigens in previously sensitized ocular tissues, we used a nonhuman primate model of ocular toxoplasmosis. Each eye of eight monkeys was inoculated with living Toxoplasma organisms into the inner retinal layers. All eyes developed necrotizing retinochoroiditis. Healing of the lesion occurred with the formation of a retinochoroiditic scar. Four months later, Toxoplasma antigens were injected through the right internal carotid artery. Four weeks after this, Toxoplasma antigens were inoculated into the left retina. Iritis, vitritis, and retinal edema occurred in response to the administration of the antigens, but no recurrent necrotizing retinochoroiditis was produced in this model. These findings suggested that hypersensitivity to Toxoplasma antigens does not play a major role in triggering recurrences of toxoplasmic retinochoroiditis in nonhuman primates.
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology*; D002825:Chorioretinitis / Q000276:immunology / Q000473:pathology; D004487:Edema / Q000276:immunology; D005128:Eye Diseases / Q000276:immunology; D005260:Female; D000882:Haplorhini; D006967:Hypersensitivity / Q000276:immunology*; D008297:Male; D012008:Recurrence; D014124:Toxoplasmosis, Animal / Q000276:immunology; D014126:Toxoplasmosis, Ocular / Q000276:immunology* / Q000473:pathology; D014822:Vitreous Body / Q000276:immunology
chemical_list: D000941:Antigens