[Inhibition of the growth of Ehrlich transplantable carcinoma in mice by antichorionic immune serum].
The literature data suggest the promotion of tumor cell implantation by chorionic gonadotropin. This hypothesis stimulated a study on the effect of antichorionic serum on the growth of Ehrlich solid carcinoma. An immune serum to chorionic gonadotropin obtained by immunization of rabbits was injected into mice with Ehrlich carcinoma transplanted under the skin of the back. Intramuscular injections of 0.1 ml were given twice a day for 14-21 days. A 45% inhibition of tumor growth (p less than 0.05) was observed after injection of serum with a high titer of antibodies to chorionic gonadotropin (1:10,000). It was matched by a much lower inhibition (21%), following injection of a low-titer serum (1:100). These results may be used as a rationale for development of an anahormone of chorionic gonadotropin for active immunization against chorionic gonadotropin.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000628:therapy*; D002823:Chorion / Q000276:immunology*; D006063:Chorionic Gonadotropin / Q000276:immunology; D005260:Female; D007114:Immunization; D007116:Immunization, Passive; D051379:Mice; D009368:Neoplasm Transplantation; D011817:Rabbits; D013997:Time Factors
D006063:Chorionic Gonadotropin
Tormozhenie rosta perevivnoĭ kartsinomy Erlikha u mysheĭ antikhorionicheskoĭ immunoĭ syvorotkoĭ.