title: An assessment of the potential testicular toxicity of 10 pesticides using the mouse-sperm morphology assay.
abstract: Dinitrobutylphenol, chlorbenzilate, atrazine, Ordram, Telone (dichloropropene), pentachlorophenol (technical and reagent grades), Benomyl, DBCP (dibromochloropropane), and carbaryl were tested over a range of 7 doses in the mouse to assess their testicular toxicity. Measures of potential toxicity were sperm morphology, sperm counts and testicular weights. Each pesticide was injected intra-peritoneally in a single dose on each of 5 days. Testicular toxicity was assessed at 35 days. None of the pesticides tested, including the known human male testicular toxin, DBCP, produced statistically significant differences in the parameters from vehicle-injected controls.
mesh_terms: D000818:Animals; D005188:False Negative Reactions; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010575:Pesticides / Q000494:pharmacology / Q000633:toxicity*; D013076:Sperm Count / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects* / Q000473:pathology; D013737:Testis / Q000187:drug effects* / Q000473:pathology
chemical_list: D010575:Pesticides