[Sialic acid content of individual tissue glycolipids in rats under normal conditions and in alloxan diabetes].
Thin-layer chromatography on silica gel was used to identify individual gangliosides in the rat brain, cardiac, renal, spleen, pancreatic and skeletal muscles in health and to measure the content of sialic acid in the above organs. A dramatic decrease in mono-, di-, tri- and polysialoganglioside levels was seen in tissues of rats with alloxan diabetes. The data obtained indicate that insulin reception disorders may be provoked by the reduced content of acidic glycolipids in plasma membranes.
D000496:Alloxan; D000818:Animals; D001921:Brain / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006017:Glycolipids / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism; D051381:Rats; D012794:Sialic Acids / Q000378:metabolism; D013154:Spleen / Q000378:metabolism
D006017:Glycolipids; D012794:Sialic Acids; D000496:Alloxan
Soderzhanie sialovykh kislot individual'nykh glikolipidov tkaneĭ v norme i pri alloksanovom diabete u krys.