[Effect of cordiamine on the enzyme activity of the electron-transport chains of the rat liver cytoplasmic network].
Injection of cordiamine (diethylamide of nicotinic acid) into rats subcutaneously in doses of 40 and 120 mg/kg for 4 days led to an increase in the activity of NADPH-oxidase, NADPH-cytochrome-c- and nitrotetrasolium reductases, as well as to an elevation of cytochrome P450 content in the liver cytoplasmic network. As regards the pattern of enzyme induction, cordiamine is classified with inductors of the phenobarbital type. However, as to the activation potency, it is noticeably inferior to phenobarbital. Electron-transport function of the enzymes of the NADH-dependent redox-chain of the organella does not show essential changes after cordiamine injection.
D000818:Animals; D003593:Cytoplasm / Q000187:drug effects* / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D004579:Electron Transport / Q000187:drug effects; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000201:enzymology; D014453:Glucuronosyltransferase / Q000378:metabolism; D006900:Hydroxylation; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009552:Nikethamide / Q000494:pharmacology*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats
D009552:Nikethamide; D014453:Glucuronosyltransferase; D010634:Phenobarbital
Vliianie kordiamina na aktivnost' fermentov élektronno-transportnykh tsepeĭ tsitoplazmaticheskoĭ seti pecheni krys.