Anticonvulsant activity of some 2-aminoethanesulphonic acid (taurine) derivatives.
A number of aliphatic 2-aminoethanesulphonic acid (taurine) derivatives were tested for their anticonvulsant activity in maximal electroshock seizure and pentylenetetrazole seizure threshold tests in mice. Certain piperidino, benzamido, phthalimido and phenylsuccinylimido derivatives were effective. Phthalimidoethanesulphon-N-methylamide, which inhibited the binding of both taurine and GABA to isolated synaptic membranes, appeared the best anticonvulsant among the derivatives tested.
D000818:Animals; D000927:Anticonvulsants; D001921:Brain / Q000378:metabolism; D066298:In Vitro Techniques; D051379:Mice; D011597:Psychomotor Performance / Q000187:drug effects; D013329:Structure-Activity Relationship; D013570:Synaptic Membranes / Q000378:metabolism; D013654:Taurine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000927:Anticonvulsants; D013654:Taurine; D005680:gamma-Aminobutyric Acid