Modeling and prospects for study of cardiovascular pathology with the artificial heart.
A series of models of the artificial heart has been developed for simulating different heart defects including stenosis of the atrioventricular ostium and mitral and tricuspid incompetence. Simulation of ventricular fibrillation is also possible. Repeated perturbation and restoration of artificial heart function are possible in the same animal. These processes are controlled externally. The surgical technique of implanting the artificial heart does not differ from the usual technique. Models of the artificial heart permit the study of fundamental problems in the physiology and pathology of the cardiovascular system.
D000818:Animals; D006345:Heart Septal Defects, Ventricular / Q000503:physiopathology; D006349:Heart Valve Diseases / Q000503:physiopathology; D006354:Heart, Artificial; D008955:Models, Cardiovascular; D014693:Ventricular Fibrillation / Q000503:physiopathology