title: Cimetidine psychotoxicity without significant medical illness: case report.
abstract: Previous reports have described cimetidine psychotoxicity as predominantly an organic brain syndrome in older, severely ill patients. This paper reports a cimetidine-induced mental state change in a middle-aged man with a relatively uncomplicated medical history. Since toxic effects of cimetidine are likely to occur within 1 to 2 days of starting the medication, close observation during this time period, and prompt recognition of psychotoxicity, can prevent disruptive side effects.
mesh_terms: D002927:Cimetidine / Q000009:adverse effects* / Q000627:therapeutic use; D004347:Drug Interactions; D004942:Esophagitis, Peptic / Q000188:drug therapy; D000431:Ethanol / Q000009:adverse effects; D006146:Guanidines / Q000009:adverse effects*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000139:chemically induced*; D008875:Middle Aged
chemical_list: D006146:Guanidines; D000431:Ethanol; D002927:Cimetidine