Familial cerebellar ataxia and hypogonadotropic hypogonadism: evidence for hypothalamic LHRH deficiency.
A family with familial cerebellar ataxia and hypogonadotropic hypogonadism is described. The condition was inherited as an autosomal recessive defect. CT scan in one case revealed cerebellar and brain stem atrophy. Endocrinological tests showed abnormalities only in two patients who were clinically affected. In both cases raised gonadotropic levels were found after repetitive stimulation with luteining hormone-releasing hormone which suggests that the hypogonadism was due to a primary hypothalamic disturbance.
D000328:Adult; D001284:Atrophy; D001933:Brain Stem / Q000473:pathology; D002524:Cerebellar Ataxia / Q000235:genetics*; D002531:Cerebellum / Q000473:pathology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005808:Genes, Recessive; D007987:Gonadotropin-Releasing Hormone / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D007006:Hypogonadism / Q000235:genetics*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010375:Pedigree; D011388:Prolactin / Q000097:blood; D013739:Testosterone / Q000097:blood; D014057:Tomography, X-Ray Computed
D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone