The effect of intravenous clonidine hydrochloride on the isolated forearm venous segment in heart failure.
The effects of intravenous (IV) clonidine (150 micrograms) on the isolated forearm venous segment of ten patients with heart failure were studied. Clonidine reduced pressure in the isolated venous segment of all patients (12.8 +/- 2.1 to 10.6 +/- 1.4 mm Hg, p less than 0.005). In addition, IV clonidine decreased the pressor response to mental arithmetic (2.9 +/- 0.3 mm Hg to 1.8 +/- 0.3 mm Hg, p less than 0.05), while the pressor response to deep breath was slightly enhanced (4.5 +/- 0.8 mm Hg to 6.1 +/- 0.7 mm Hg, p less than 0.05).
D000328:Adult; D000368:Aged; D003000:Clonidine / Q000627:therapeutic use*; D005542:Forearm / Q000098:blood supply; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D011674:Pulse; D014655:Vascular Resistance / Q000187:drug effects; D014690:Venous Pressure / Q000187:drug effects
D003000:Clonidine