Gilvocarcins, new antitumor antibiotics. 4. Mode of action.
The mode of action of gilvocarcins was studied. Gilvocarcins V, M and A possessed antibacterial activities decreasing in that order. Gilvocarcin V inhibited DNA synthesis in Bacillus subtilis through strong interaction with DNA and resulting cleavage. Gilvocarcin M showed interaction with DNA and a small change in DNA mobility upon electrophoresis in agarose gel, while gilvocarcin A showed no interaction with DNA, thus reflecting their relative biological activities.
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000378:metabolism; D001419:Bacteria / Q000187:drug effects; D001426:Bacterial Proteins / Q000096:biosynthesis; D003374:Coumarins; D004269:DNA, Bacterial / Q000378:metabolism; D006027:Glycosides / Q000494:pharmacology; D009696:Nucleic Acids / Q000096:biosynthesis
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D001426:Bacterial Proteins; D003374:Coumarins; D004269:DNA, Bacterial; D006027:Glycosides; D009696:Nucleic Acids; C031782:gilvocarcin M; C031781:gilvocarcin V