[Effect of diamide derivatives of imidazole- and pyrazoledicarboxylic acids on glyolysis indices depending on their structural characteristics].
A study was made of the effect of diamide derivatives of imidazole- and pyrazole-dicarboxylic acids on blood glycolysis in rabbits depending on structural and conformational features of the molecules. It was shown that glycolysis is affected by the position and magnitude of an alkyl substituent in the heterocyclic part of the molecule. An essential role in the manifestation of metabolic activity is played by structural similarity of the test compounds to the adenine molecule.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008968:Molecular Conformation; D010084:Oxidation-Reduction / Q000187:drug effects; D011720:Pyrazoles / Q000494:pharmacology*; D011773:Pyruvates / Q000097:blood; D019289:Pyruvic Acid; D011817:Rabbits; D013329:Structure-Activity Relationship; D013997:Time Factors
D001786:Blood Glucose; D007093:Imidazoles; D007773:Lactates; D011720:Pyrazoles; D011773:Pyruvates; D019344:Lactic Acid; D019289:Pyruvic Acid
Vliianie proizvodnykh diamidov imidazol- i pirazoldikarbonovykh kislot na pokazateli glikoliza v zavisimosti ot osobennosteĭ ikh struktury.