title: Spontaneous mediastinal hemorrhage. A complication of intracoronary streptokinase infusion for coronary thrombosis.
abstract: A 72-year-old man with a recent inferior-wall myocardial infarction complicated by continued ischemic cardiac pain underwent an intracoronary streptokinase infusion in an attempt to re-establish coronary perfusion. Although the cardiac catheterization and streptokinase infusion were technically uncomplicated, signs of an enlarging mediastinal mass associated with a drop in the hematocrit reading developed in the patient 12 hours after the procedure. Aortography showed no evidence of aortic dissection or laceration. The patient was believed to have a spontaneous mediastinal hemorrhage related to streptokinase infusion.
mesh_terms: D000368:Aged; D003327:Coronary Disease / Q000188:drug therapy*; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008477:Mediastinal Diseases / Q000139:chemically induced*; D010996:Pleural Effusion / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011859:Radiography; D013300:Streptokinase / Q000009:adverse effects*
chemical_list: D013300:Streptokinase