Toxic epidermal necrolysis in a patient treated with gold salts and benoxaprofen.
Fatal toxic epidermal necrolysis is described in a patient, treated concurrently with sodium aurothiomalate and benoxaprofen, who had previously had these two drugs separately, with only minor mucocutaneous problems while on gold, and no adverse effects from benoxaprofen. It is suggested that benoxaprofen could act synergistically with gold, resulting in enhancement of mucocutaneous side-effects, which are common to both these drugs.
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D004357:Drug Synergism; D005260:Female; D006052:Gold Sodium Thiomalate / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D010003:Osteoarthritis / Q000188:drug therapy; D011422:Propionates / Q000009:adverse effects* / Q000627:therapeutic use; D018805:Sepsis / Q000209:etiology; D013262:Stevens-Johnson Syndrome / Q000150:complications / Q000209:etiology*
D000893:Anti-Inflammatory Agents; D011422:Propionates; D006052:Gold Sodium Thiomalate; C011677:benoxaprofen