Specific induction of erythroleukemia and myelogenous leukemia in Sprague-Dawley rats.
The experimental induction of leukemias of two sorts by two powerful chemical carcinogens was investigated in rats of a single strain. In Sprague-Dawley rats a series of intravenous injections of N-nitroso-N-methylurea selectively elicited myelogenous leukemia in high yields, whereas erythroleukemia was not evoked. Conversely, a set of intravenous injections of 7,8,12-trimethylbenz[a]anthracene specifically elicited erythro-leukemia in high incidence in the rats, whereas myelogenous leukemia was not produced.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000031:analogs & derivatives; D000818:Animals; D006400:Hematocrit; D007942:Leukemia, Experimental / Q000139:chemically induced / Q000503:physiopathology*; D007951:Leukemia, Myeloid / Q000139:chemically induced / Q000503:physiopathology*; D007958:Leukocyte Count; D008770:Methylnitrosourea; D051381:Rats; D011919:Rats, Inbred Strains
C029538:7,8,12-trimethylbenz(a)anthracene; D015127:9,10-Dimethyl-1,2-benzanthracene; D008770:Methylnitrosourea