Human pial vascular reactions to intravenous Nimodipine-infusion during EC-IC bypass surgery.
In previous experimental work, the Ca-antagonist Nimodipine had shown a predominantly cerebroarterial dilatory effect. In the present double-blind study of 16 patients, pial arterial and venous reaction was investigated during EC-IC bypass surgery, infusing 1 microgram kg-1min-1 of Nimodipine intravenously. In pial arteries with resting diameters between 25 and 70 micrometers, a significant 18% dilatation was observed. Results are considered promising for future trials in the treatment and prevention of cerebral ischemia caused by vasoconstriction or vasospasm, especially vasospasm following subarachnoid hemorrhage.
D000328:Adult; D000368:Aged; D001921:Brain / Q000098:blood supply*; D002548:Cerebral Revascularization; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D009539:Nicotinic Acids / Q000008:administration & dosage*; D009553:Nimodipine; D010841:Pia Mater / Q000098:blood supply; D014664:Vasodilation / Q000187:drug effects*
D009539:Nicotinic Acids; D009553:Nimodipine