title: Low doses of X-rays decrease the risk of diploidy in mouse oocytes.
abstract: Females from the NMRI/Han mouse strain ovulate a high number of diploid oocytes (about 12%) after gonadotrophin-stimulated ovulation. These oocytes can be fertilized and develop into triploid embryos subsequently. The exposure of such gonadotrophin-primed females to X-ray doses of 0.05, 0.10, 0.20 or 0.40 Gy during the preovulatory period (2 h after the HCG dose) significantly decreased the percentage of diploid oocytes. After the highest dose used, i.e. 0.80 Gy, however, the incidence was on the level from unirradiated females, again. We suggest that the observed negative hump-shaped dose response of diploidy is not caused by secondary modifications induced by irradiation, such as a selective killing of diploid oocytes before ovulation, or a (compensatory) super-ovulation of only normal oocytes, but rather is caused by a direct radiobiological interference of low doses in protecting from gonadotrophin-induced aneuploidy.
mesh_terms: D000782:Aneuploidy; D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D004171:Diploidy; D004307:Dose-Response Relationship, Radiation; D005260:Female; D051379:Mice; D009865:Oocytes / Q000528:radiation effects*; D010063:Ovum / Q000528:radiation effects*; D014965:X-Rays
chemical_list: D006063:Chorionic Gonadotropin