title: [Treatment of a severe coronary artery spasm, refractory to complete denervation of the heart (autotransplantation)].
abstract: The case reported is that of a 49 year old man with very severe Prinzmetal angina due to spasm of the left circumflex artery. Despite intensive medical treatment he continued to suffer frequent attacks with atrioventricular block. As plexectomy was not possible in this case, complete cardiac denervation was performed. After surgery, he had no further attacks and continuous ECG monitoring showed no ischemic phenomena. Nevertheless, a stress test was still able to induce spasm of the same artery which was painless but associated with ECG changes. Eighteen months postoperatively, resting angina recurred with positive stress tests giving painful attacks. Four hypotheses are discussed: 1) the local factor was very important, with a zone of hyperactivity on the left circumflex artery, 2) one of the mechanisms of coronary artery spasm could be the nervous stimulation of this zone, 3) this zone was insensitive to nervous stimulation after autotransplantation but remained sensitive to methylergometrine, 4) the recurrence of resting angina and painful symptoms on stress testing suggests the possibility of reinnervation of the heart, as has been shown after cardiac transplantation, the autonomic nervous system does not play the role generally attributed to it in the genesis of spasm.
mesh_terms: D000368:Aged; D000788:Angina Pectoris, Variant / Q000209:etiology; D003329:Coronary Vasospasm / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D003714:Denervation; D004562:Electrocardiography; D006321:Heart / Q000294:innervation; D006327:Heart Block / Q000209:etiology; D006801:Humans; D008297:Male; D011859:Radiography; D012008:Recurrence
vernacular_title: Traitement d'un spasme artériel coronaire sévère, réfractaire par dénervation complète du coeur (autotransplantation).