Comparative studies on spontaneous and mitomycin-C-induced sister-chromatid exchanges in smokers and non-smokers.
Both spontaneous and mitomycin-C-induced sister-chromatid exchanges were analyzed in 6 smokers and 6 non-smokers. The average number of spontaneous SCE in smokers' cells was 8.33 +/- 1.08. The frequency in the non-smoking controls was 4.41 +/- 0.72. This difference is highly significant (P less than 0.001). Smokers also had more SCE at all levels of mitomycin C testes. Analysis of variance showed these differences to be highly significant (P less than 0.001).
D002478:Cells, Cultured; D003434:Crossing Over, Genetic / Q000187:drug effects; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects; D012907:Smoking
D008937:Mitomycins; D016685:Mitomycin