title: Evaluation of ocular toxicity of two beta blocking drugs, carteolol and practolol, in beagle dogs.
abstract: The ocular effects of two beta blocking drugs, carteolol and practolol, were assessed in beagle dogs. Practolol-treated dogs showed a tear flow reduction: histopathological examination showed lymphocytic infiltration in the lacrymal glands and electroretinogram showed a decrease in the amplitudes of the A + B-wave. By contrast, no drug-related abnormal changes were observed in carteolol-treated dogs. These results were thought to indicate that a tear flow measurement and electroretinogram examination should be used in the evaluation of the safety of beta blocking drugs.
mesh_terms: D000818:Animals; D002354:Carteolol / Q000633:toxicity*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004596:Electroretinography; D005654:Fundus Oculi; D007765:Lacrimal Apparatus / Q000187:drug effects / Q000473:pathology*; D008297:Male; D011217:Practolol / Q000633:toxicity*; D011412:Propanolamines / Q000633:toxicity*; D013666:Tears / Q000187:drug effects / Q000378:metabolism
chemical_list: D011412:Propanolamines; D002354:Carteolol; D011217:Practolol