Induction of cytogenetic effects in human fibroblast cultures after exposure to formaldehyde or X-rays.
Cytogenetic changes induced by formaldehyde (FA) in exponentially growing human fibroblasts were compared with those produced by X-rays. Chromosome aberrations of different types were detected. Exposure to 2 mM FA for 15 min resulted, quantitatively and qualitatively, in effects comparable to those produced by an X-ray dose of 100 rad. X-Rays at higher exposures produced types of chromosome aberrations that differed from those induced by higher exposures to FA.
D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects* / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000648:ultrastructure; D005557:Formaldehyde / Q000494:pharmacology*; D006801:Humans; D014965:X-Rays
D005557:Formaldehyde