The influence of some thiols on biliary excretion of methyl mercury.
N-Acetylpenicillamine and thiola increased biliary excretion of methyl mercury and sulfhydryl right after administration. Cysteine increased excretion of methyl mercury in bile after a temporary decrease following administration. During the interval of decreased mercury excretion biliary excretion of cysteine passed through a maximum. This indicates the existence of a common factor of the excretory systems for cysteine and methyl mercury and illustrates that cysteine cannot carry methyl mercury from liver to bile. Relatively large proportions of unchanged thiola and N-acetylpenicillamine were excreted in bile. Bile collected after administration of one of these compounds, in addition to thiola or N-acetylpenicillamine, contained other methyl mercury carrying components not present in control bile. From the experiments undertaken it cannot be stated whether these components play any role in the increased excretion of methyl mercury in bile caused by thiola and N-acetylpenicillamine. The mechanisms of increased biliary excretion of methyl mercury following administration of N-acetylpenicillamine, thiola and cysteine are discussed.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D003545:Cysteine / Q000494:pharmacology; D008297:Male; D008628:Mercury / Q000378:metabolism; D008631:Mercury Radioisotopes; D008767:Methylmercury Compounds / Q000378:metabolism*; D010396:Penicillamine / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D013997:Time Factors; D008625:Tiopronin / Q000494:pharmacology
D008631:Mercury Radioisotopes; D008767:Methylmercury Compounds; D013438:Sulfhydryl Compounds; C010005:N-acetylpenicillamine; D008625:Tiopronin; D008628:Mercury; D010396:Penicillamine; D003545:Cysteine