The isolation and amino acid composition of senile plaque core protein.
A new method has been developed for the isolation of intact senile (neuritic) plaque cores from post-mortem brains of patients with Alzheimer's disease. The plaque cores were found to be insoluble in various protein denaturants. The amino acid composition of the plaque core protein does not resemble that of any known form of amyloid.
D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism; D000682:Amyloid / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D003704:Dementia / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009454:Neurofibrils / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism
D000596:Amino Acids; D000682:Amyloid; D009419:Nerve Tissue Proteins