Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.
The amino acid sequence of a segment of 106 residues of C4d has been determined by automated sequence analysis of fragments obtained by CNBr cleavage and enzymic digestion with trypsin. Polymorphism has been detected at 3 positions. Residues 9 and 12 are either valine and leucine or alanine and arginine, respectively. Residue 102 is either valine or arginine. When comparing the protein sequence with the nucleic, acid sequence [Carroll, M. and Porter, R.R. (1983) Proc. Natl. Acad. Sci. USA 80, in press] alanine or serine are found at position 98. These results may in part help to explain the inherited variants of human C4 seen on gel electrophoresis.
D000595:Amino Acid Sequence; D003181:Complement C4 / Q000032:analysis* / Q000235:genetics; D015935:Complement C4b; D003488:Cyanogen Bromide; D006801:Humans; D010446:Peptide Fragments / Q000032:analysis* / Q000235:genetics; D011110:Polymorphism, Genetic; D014357:Trypsin / Q000378:metabolism
D003181:Complement C4; D010446:Peptide Fragments; D015935:Complement C4b; C032261:complement C4d; D014357:Trypsin; D003488:Cyanogen Bromide