title: The effects of aldosterone on sodium and potassium metabolism in larval Ambystoma tigrinum.
abstract: Electrolyte depletion resulting from 14 days in distilled water, which was changed daily, lowered plasma Na concentration from 108 to 92 mM. Aminoglutethimide was administered on each of the final 3 days of the depletion period in doses of 3 mg/animal. This further depressed Na to 75 mM. Both aldosterone (25 micrograms/animal) and corticosterone (200 micrograms/animal) returned plasma Na to 92 mM. Cortisone (200 micrograms/animal) was ineffective. There were no consistent patterns in plasma K. Renal clearance experiments showed that the same dose of aminoglutethimide decreased fractional tubular Na reabsorption and increased fractional tubular K reabsorption. Aldosterone reversed these trends suggesting that this hormone may play a role in controlling renal electrolyte excretion.
mesh_terms: D000450:Aldosterone / Q000494:pharmacology*; D000557:Ambystoma / Q000378:metabolism*; D000616:Aminoglutethimide / Q000494:pharmacology; D000818:Animals; D003345:Corticosterone / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D007684:Kidney Tubules / Q000187:drug effects / Q000378:metabolism; D007814:Larva / Q000378:metabolism; D011188:Potassium / Q000378:metabolism*; D012964:Sodium / Q000172:deficiency / Q000378:metabolism*
chemical_list: D000616:Aminoglutethimide; D000431:Ethanol; D000450:Aldosterone; D012964:Sodium; D011188:Potassium; D003345:Corticosterone