Unfavorable neonatal outcome after intraamniotic injection of methylene blue.
A case is presented in which methylene blue dye was injected intraamniotically to confirm rupture of the membranes. Significant neonatal morbidity occurred as a direct result of the methylene blue dye injection. A syndrome of toxic side effects is described including hemolytic anemia, hyperbilirubinemia, and methemoglobinemia. The metabolic process is discussed. The authors suggest discontinuing the intraamniotic injection of methylene blue dye as a diagnostic aid.
D000650:Amnion; D000743:Anemia, Hemolytic / Q000139:chemically induced; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000139:chemically induced*; D007267:Injections; D007567:Jaundice, Neonatal / Q000139:chemically induced / Q000628:therapy; D008708:Methemoglobinemia / Q000139:chemically induced; D008751:Methylene Blue / Q000008:administration & dosage*; D011247:Pregnancy
D008751:Methylene Blue