[Immunohistochemical demonstration of the complement component C 4 in bile thrombi and liver cells in pseudoglandular transformation of hepatocytes (author's transl)].
The paper describes the immunohistochemical demonstration of complement component C 4 in a case of pseudoglandular transformation of liver cells caused probably by viral hepatitis. C 4 could be found first of all in the lumen of dilated bile canaliculi (in position with "bile thrombi"), further in the cytoplasm of hepatocytes and Kupffer cells, on their plasma membranes, in the sinusoids, and in necrosis. Probably, these observations indicate a disturbance of the synthesis and catabolic mechanisms of complement and/or of immune complexes. The findings so far support the hypothesis that the pseudoglandular transformation of liver cells is the vain attempt of the liver to eliminate or sequestrate of own or foreign material, e.g. immune complexes.
D000328:Adult; D000818:Animals; D001648:Bile Canaliculi / Q000032:analysis*; D001653:Bile Ducts, Intrahepatic / Q000032:analysis*; D002472:Cell Transformation, Viral; D003181:Complement C4 / Q000032:analysis*; D005260:Female; D006505:Hepatitis / Q000503:physiopathology; D006651:Histocytochemistry; D006801:Humans; D008099:Liver / Q000032:analysis* / Q000648:ultrastructure; D011817:Rabbits
D003181:Complement C4
Immunhistologischer Nachweis der vierten Komplementkomponente in Gallethromben und Leberzellen bei pseudoglandulärer Transformation der Hepatocyten.