[Hemodynamic mechanism of the hypotensive action of beta-phenyl-GABA esters (phenibut)].
It was established in acute and chronic experiments on cats that phenibut ethers are 7-10 times more potent than phenibut itself as regards hypotensive activity and produce inconsistent effects on the cardio- and hemodynamics. Of these ethers, methyl ether of phenibut is the most powerful agent. It causes lasting hypotension when given in doses of 1/50 and 1/30 of the LD50 at the cost of a decrease in the general peripheral resistance. At the same time, apart from raising the blood inflow to the heart and cardiac output, the drug has a compensated adverse ino- and chronotropic action on the heart.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007928:Lethal Dose 50; D051379:Mice; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity
D000959:Antihypertensive Agents; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid
Izuchenie gemodinamicheskogo mekhanizma gipotenzivnogo deĭstviia efirov beta-fenil-GAMK (fenibuta).