title: Zinc deficiency and the kidney. I. Effect on renal carbonic anhydrase activity.
abstract: Tissue zinc concentration and the activity of the zinc metalloenzyme, carbonic anhydrase, were quantified in whole blood and kidneys of weanling male Sprague-Dawley rats with diet-induced zinc deficiency. Zinc-deficient rats were fed ad libitum a commercially prepared diet containing less than 1 ppm zinc. Zinc-supplemented rats were ad libitum or pair-fed a control diet containing 60 ppm zinc. All animals were fed their respective diets for 3-6 weeks. Body and kidney growth were severely compromised after 3 and 6 weeks of feeding the zinc-deficient diet. Plasma and kidney zinc concentrations were significantly decreased in zinc-deficient animals after 6 weeks. While whole blood carbonic anhydrase activity of zinc-deficient rats was significantly greater than zinc-supplemented animals after 6 weeks, no differences in renal carbonic anhydrase activity were found between zinc-deficient animals and pair-fed controls. Results reported in this study suggest that zinc deficiency imposed at weaning in rats may be a contributing factor to retarded kidney maturation and alterations in blood carbonic anhydrase activity.
mesh_terms: D000818:Animals; D001835:Body Weight; D002256:Carbonic Anhydrases / Q000032:analysis*; D007668:Kidney / Q000033:anatomy & histology / Q000201:enzymology*; D008297:Male; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000097:blood / Q000172:deficiency*
chemical_list: D002256:Carbonic Anhydrases; D015032:Zinc