Elimination kinetics of iopamidol, a new water soluble nonionic radiographic contrast medium, analyzed by radioactivation.
We have studied the elimination kinetics of iopamidol employing radioactivation and radiochemical separation. This method offers the advantage of guaranteeing absolutely no interference by radiation with tissue distribution or elimination kinetics of the analyzed compound. Our results show that iopamidol does not cross the blood-brain barrier, has no effect on thyroid iodine uptake and does not accumulate in the liver.
D000818:Animals; D001921:Brain / Q000378:metabolism; D003287:Contrast Media; D007455:Iodine / Q000097:blood / Q000378:metabolism; D007479:Iopamidol; D007483:Iothalamic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D011854:Radiochemistry; D051381:Rats; D011919:Rats, Inbred Strains; D012995:Solubility; D013961:Thyroid Gland / Q000378:metabolism; D014867:Water
D003287:Contrast Media; D014867:Water; D007483:Iothalamic Acid; D007455:Iodine; D007479:Iopamidol