title: Effect of short-term sleep loss on breathing.
abstract: Loss of sleep is common among patients with respiratory disorders. We studied ventilatory performance in 15 normal subjects to determine whether a single night of sleep loss would have any detectable effect on breathing. Spirometry and hypercapnic ventilatory response testing were performed daily for 3 consecutive days with no sleep permitted between testing on days 1 and 2. We found a small but significant decline in forced vital capacity and maximal voluntary ventilation and a 20% decrease in hypercapnic ventilatory response slope after sleep loss (P less than 0.05). We conclude that sleep loss results in a significant deterioration in ventilatory performance, which may be clinically important to patients with respiratory diseases.
mesh_terms: D000328:Adult; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D006801:Humans; D006935:Hypercapnia / Q000097:blood / Q000503:physiopathology*; D008168:Lung / Q000503:physiopathology*; D008297:Male; D010100:Oxygen / Q000097:blood; D012119:Respiration; D012892:Sleep Deprivation / Q000502:physiology*; D013147:Spirometry
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen