title: Antidepressant drugs, convulsions and epilepsy.
abstract: 1 Evidence concerning the convulsant effects of non-monoamine oxidase inhibitor antidepressant drugs has been reviewed. 2 Mianserin is convulsant in therapeutic doses but seizures have not been reported following overdose. 3 The convulsant effects of mianserin are probably no greater than for other non-monoamine oxidase inhibitor antidepressant drugs. 4 Enzyme-inducing anti-epileptic drugs can reduce the peak plasma concentration of mianserin and shorten its elimination half-life, probably by inducing its metabolism.
mesh_terms: D000928:Antidepressive Agents / Q000009:adverse effects*; D004347:Drug Interactions; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced*; D006801:Humans; D007700:Kinetics; D012640:Seizures / Q000139:chemically induced*
chemical_list: D000928:Antidepressive Agents