Pharmacological improvement of altered red cell deformability.
Red cell deformability can be approached on a large clinical scale using filtration methods. Filtration and/or deformability have been shown to be reduced during vascular diseases. The biochemistry of red cell deformability can help to understand this phenomenon. Pentoxifylline increases red cell deformability. Its clinical efficacy in circulatory impairment is demonstrated.
D000255:Adenosine Triphosphate / Q000378:metabolism; D004492:Edetic Acid / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D010431:Pentoxifylline / Q000494:pharmacology; D010766:Phosphorylation; D012306:Risk; D013049:Spectrin / Q000502:physiology; D014462:Ultrafiltration; D014652:Vascular Diseases / Q000097:blood
D013049:Spectrin; D000255:Adenosine Triphosphate; D004492:Edetic Acid; D010431:Pentoxifylline