Impairment of neutrophil chemotaxis by serum from patients with chronic lymphoproliferative disease.
The sera of 74 individuals with chronic lymphoproliferative disease were screened for the presence of inhibitory activity against neutrophil chemotaxis. This was present in more than half the patients with IgA myeloma and Hodgkin's disease but was less common in chronic lymphocytic leukaemia, lymphocytic lymphoma and non-IgA paraproteinaemia. Heating the sera prior to testing frequently enhanced inhibitory activity particularly in myeloma and lymphoma.
D001769:Blood; D002634:Chemotaxis, Leukocyte; D003956:Dialysis; D006358:Hot Temperature; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology; D010265:Paraproteinemias / Q000276:immunology*