Dialyzability of methyl-GAG.
Methyl-GAG at low doses was administered to an anephric male patient with metastatic hypernephroma, who required hemodialysis. No toxicity was observed. Measurement of serum levels of methyl-GAG showed that the drug is dialyzable. Thus, when methyl-GAG is considered for patients who are anephric and are being dialyzed, full doses are allowable. In addition, dialysis should be effective in rapidly eliminating the drug in patients who develop toxic effects.
D000230:Adenocarcinoma / Q000188:drug therapy*; D006146:Guanidines / Q000008:administration & dosage*; D006801:Humans; D007263:Infusions, Parenteral; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008935:Mitoguazone / Q000008:administration & dosage* / Q000097:blood; D006435:Renal Dialysis
D006146:Guanidines; D008935:Mitoguazone