3H-Imipramine high-affinity binding sites in rat brain. Effects of imipramine and lithium.
The specific high-affinity binding of 3H-imipramine to rat brain membranes was investigated. Five weeks of lithium treatment decreased the number of binding sites, but had no effect on the affinity constants. Long-term imipramine treatment had no effect on the number of binding sites but apparently decreased the affinity. The latter effect was probably due to imipramine remaining in the membrane preparation.
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D005260:Female; D007099:Imipramine / Q000378:metabolism* / Q000494:pharmacology; D007700:Kinetics; D008094:Lithium / Q000494:pharmacology*; D008566:Membranes / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D008094:Lithium; D007099:Imipramine