Gametogenic count and histopathological effect of thorium nitrate and uranyl nitrate on mice testes.
Daily intraperitoneal administration of aqueous solution of 0.05 m mole/100 g b. wt. of uranyl nitrate and thorium nitrate has been observed for 7 days. Marked reduction in the seminiferous tubule diameter and gametogenic count was observed. Signs of testicular necrosis, exfoliation of germ cells, and karyolysis and karyorrhexis were seen in most of the tutubles. Mononucleate and polynucleate giant cells were also observed indicating prolonged pathological condition.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D007985:Leydig Cells / Q000648:ultrastructure; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D013076:Sperm Count; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D013910:Thorium / Q000494:pharmacology*; D017970:Thorium Compounds; D014501:Uranium / Q000494:pharmacology*; D014502:Uranyl Nitrate / Q000494:pharmacology*
D017970:Thorium Compounds; D014502:Uranyl Nitrate; D014501:Uranium; D013910:Thorium; C036680:thorium nitrate