[Role of iron and a siderophore in the development of bacterial infections in the mouse: the study of two bacteria and three routes of inoculation].
We have studied the influence of ferric iron and the influence of a siderophore on the lethal activity of two Bacteria injected in Mice intraperitoneally intravenously or orally. Iron and the siderophore significatively increase the lethal activity of an avirulent Bacteria, Enterobacter cloacae, injected intraperitoneally or intravenously. The virulence of a Bacteria pathogen for Mice, Salmonella typhimurium, is also increased when injected intraperitoneally. Therefore we have noted a decrease in virulence when this Bacteria was injected intravenously or orally in Mice treated with the siderophore.
D000284:Administration, Oral; D000818:Animals; D003676:Deferoxamine / Q000494:pharmacology*; D004754:Enterobacter / Q000187:drug effects; D004756:Enterobacteriaceae Infections / Q000503:physiopathology*; D005260:Female; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007501:Iron / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012480:Salmonella Infections / Q000503:physiopathology*; D012486:Salmonella typhimurium / Q000187:drug effects
D007501:Iron; D003676:Deferoxamine
Rôle du fer et d'un siderochrome dans le développement d'infections bactériennes chez la souris: étude de deux bactéries et de trois voies d'inoculation.