Thrombocytopenia secondary to trimethoprim-sulfamethoxazole.
Two patients had severe thrombocytopenia while taking trimethoprim-sulfamethoxazole. The mechanism is uncertain, but probably is related to drug interference with folate metabolism. Recovery can usually be expected upon withdrawal of the medication and institution of folic acid therapy.
D000208:Acute Disease; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010033:Otitis Media / Q000188:drug therapy; D010976:Platelet Count; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000188:drug therapy; D014295:Trimethoprim / Q000008:administration & dosage / Q000009:adverse effects*
D005492:Folic Acid; D014295:Trimethoprim; D013420:Sulfamethoxazole