Clinical applications of fluorometry.
An instrument has been developed that measures in ten seconds the level of fluorescein along a scanning line from the retina to the cornea. With spatial resolving power of 1.1 mm in the eye, concentrations of 1 X 10(-8) gr/ml fluorescein and higher are detectable. In this way an indication of the integrity of the blood-ocular barriers is achieved. In uveitis the dysfunction is mainly localised at the blood-aqueous barrier while in diabetic retinopathy the blood-retinal barrier is predominantly affected. Sources of error are discussed.
D000328:Adult; D002830:Choroid Neoplasms / Q000175:diagnosis; D003930:Diabetic Retinopathy / Q000175:diagnosis*; D005123:Eye / Q000098:blood supply; D005128:Eye Diseases / Q000175:diagnosis*; D005260:Female; D005470:Fluorometry / Q000295:instrumentation*; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis; D008875:Middle Aged; D014605:Uveitis / Q000175:diagnosis*