[Partial blocking of the organofaction of iodine with thyroglobulin antibodies].
The influence is studied of purified thyroglobulin antibodies on a stage of thyroid hormone formation, i.e. iodine organofication, using a method of inorganic iodine replacement by potassium perchlorate. A decreased marker uptake by the thyroid and a delay of iodide inclusion into organic components were observed after incubation of rat thyroid slices and injection of a similar antiserum to normal rats 24 hours before radioactive iodine administration. The data obtained indicate that the disturbance of iodine organofication is possible under thyroglobulin antibody effect, accompanied by the thyroid autoimmune process development.
D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology*; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology*; D007455:Iodine / Q000378:metabolism*; D011817:Rabbits; D013954:Thyroglobulin / Q000276:immunology*; D013961:Thyroid Gland / Q000378:metabolism; D013963:Thyroid Hormones / Q000096:biosynthesis
D001323:Autoantibodies; D013963:Thyroid Hormones; D013954:Thyroglobulin; D007455:Iodine
Chastichnoe blokirovanie organofikatsii ĭoda tireoglobulinovymi antitelami.