Effects of working environment on the liver in 10 anaesthetists.
Drug-metabolising ability, i.e. antipyrine half-life, in anaesthetists was significantly slowed (23%) at the end of summer vacation (2-4 weeks), as compared to prevacation values. Despite changes in either direction, the antipyrine half-lives, including four determinations within a year and a half from the ten anaesthetists, were within normal limits. Liver enzymes (aspartate aminotransferase, alanine amino-transferase, alkaline phosphatase) were also normal. In one anaesthetist the test for anti-HBsAg was positive in 1980, while in the others HBsAg and anti-HBsAg were negative in 1980 and 1981. The inorganic fluoride concentrations of serum and urine (determined four times) were at normal levels. Only in one anaesthetist was there a transient, surprisingly high, serum concentration (7.9 mumol/l), apparently unrelated to work exposure.
D000328:Adult; D000776:Anesthesiology; D000983:Antipyrine; D004781:Environmental Exposure; D005260:Female; D005459:Fluorides / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male
D005459:Fluorides; D000983:Antipyrine