[Effect of nitroglycerin on myocardial function in short-term ischemia].
In acute experiments on open-chest dogs nitroglycerin (5 microgram/kg, i.v.) was injected 1 minute before a 60-second occlusion of the descending branch of the left coronary artery. At the height of ischemia nitroglycerin increased oxygen tension and produced a lowering of contractility of the deep and superficial layers of the myocardium adjacent to the zone of ischemia, this lowering was less as compared to that seen in control occlusions. Nitroglycerin did not produce marked or significant changes in oxygen tension and myocardial contractility in the central ischemic or distant areas. No significant changes in the hemodynamics were recorded either.
D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D005996:Nitroglycerin / Q000627:therapeutic use*; D010101:Oxygen Consumption / Q000187:drug effects; D010313:Partial Pressure; D013997:Time Factors
D005996:Nitroglycerin
Vliianie nitroglitserina na funktsional'noe sostoianie miokarda pri kratkovremennoĭ ishemii.