Potentiation of d-amphetamine and L-dopa-induced acoustic startle activity after long-term exposure to amphetamine.
The startle response to an auditory stimulus was potentiated by treatment with d-amphetamine sulfate. Administration of L-dopa after pretreatment with the extracerebral decarboxylase inhibitor MK-486 also increased startle activity. After long-term exposure to amphetamine the startle response to L-dopa and d-amphetamine was enhanced. These findings are consistent with the consequences of long-term amphetamine administration on other amphetamine-induced behaviors (e.g. stereotype), and are discussed in terms of the effects of long-term amphetamine treatment on pre- and postsynaptic dopamine receptors and serotonin.
D000161:Acoustic Stimulation; D000818:Animals; D002230:Carbidopa / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology*; D006801:Humans; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D051379:Mice; D013216:Reflex, Startle / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors
D007980:Levodopa; D002230:Carbidopa; D003913:Dextroamphetamine