title: Esterase-17 (ES-17): characterization and genetic location on chromosome 9 of a bis-p-nitrophenyl phosphate-resistant esterase of the house mouse (Mus musculus).
abstract: Genetic variation of a new codominantly inherited esterase, designated ES-17, has been discovered in the house mouse using isoelectric focusing in polyacrylamide gels. The ES-17 A phenotype (three bands; isoelectric points, between pH 5.55 and pH 5.90) was found in C57BL/10Sn. LP/J possessed the Es-17B phenotype (three bands; isoelectric points, pH 5.05-5.55). ES-17 was present in all tissues examined, except for hemolysate and serum, and was most clearly expressed in the small intestine. Because of its reaction toward various substrates and inhibitors, ES-17 has tentatively been classified as acetyl esterase (EC 3.1.1.6). ES-17 was shown to be controlled by the structural locus Es-17, located on chromosome 9. From test-cross data, a gene order of Es-17-8.7 +/- 2.5 map units-Mpi-1-10.2 +/- 2.7 map units-Mod-1 was established.
mesh_terms: D000115:Acetylesterase / Q000235:genetics*; D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000037:antagonists & inhibitors*; D002875:Chromosomes / Q000032:analysis; D005796:Genes; D005799:Genes, Dominant; D014644:Genetic Variation; D051379:Mice / Q000235:genetics*; D008815:Mice, Inbred Strains / Q000235:genetics; D009596:Nitrophenols / Q000494:pharmacology*; D010641:Phenotype; D013045:Species Specificity; D014018:Tissue Distribution
chemical_list: D009596:Nitrophenols; C002887:bis(4-nitrophenyl)phosphate; D002265:Carboxylic Ester Hydrolases; D000115:Acetylesterase