[Electron-cytochemical study of the changes in the structure of hyperchromic neurons shown after chlorpromazine administration].
By means of Bernhard's electron cytochemical method for revealing DNP and RNP, the hyperchromic neurons in the cerebral cortex have been investigated 3, 6, 24 and 48 hours after chlorpromazine hydrochloride administration (15 mg/kg). Development of hyperchromia in the neurons has been followed beginning from minimal changes in the nucleus and cytoplasm up to their maximal reconstruction and a subsequent restoration to the normal stage. The data obtained demonstrate that hyperchromia of the neuron during various phases of its development can be characterized both by a decreasing synthetic activity and by restorative processes during the last period when the functional state is normalized.
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D003852:Deoxyribonucleoproteins / Q000378:metabolism; D006651:Histocytochemistry; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000378:metabolism / Q000648:ultrastructure*; D051381:Rats; D012261:Ribonucleoproteins / Q000378:metabolism; D013003:Somatosensory Cortex / Q000378:metabolism / Q000648:ultrastructure*
D003852:Deoxyribonucleoproteins; D012261:Ribonucleoproteins; D002746:Chlorpromazine
Elektronno-tsitokhimicheskoe issledovanie dinamiki izmeneniia struktury giperkhromnykh neĭronov, vyiavliaemykh posle vvedeniia aminazina.