Pulmonary renal syndromes. II. Etiology and pathogenesis.
Numerous systemic diseases share immunopathogenic mechanisms. This article reviews the proposed etiologies and immunopathogenic mechanisms of a group of diseases which share pulmonary and renal abnormalities. Specifically, we discuss the following diseases: Good-pasture's syndrome, systemic lupus erythematosus, progressive systemic sclerosis, Wegener's granulomatosis, lymphomatoid granulomatosis, and Churg-Strauss syndrome.
D000818:Animals; D019867:Anti-Glomerular Basement Membrane Disease / Q000209:etiology*; D000974:Antibodies, Antinuclear / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000276:immunology; D001327:Autoimmune Diseases; D001485:Basement Membrane / Q000276:immunology; D003095:Collagen Diseases / Q000209:etiology*; D004200:Diseases in Twins; D004802:Eosinophilia / Q000276:immunology; D005921:Glomerulonephritis / Q000276:immunology; D014890:Granulomatosis with Polyangiitis / Q000209:etiology*; D000882:Haplorhini; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology; D007678:Kidney Glomerulus / Q000276:immunology; D007801:Langerhans Cells / Q000166:cytology; D008180:Lupus Erythematosus, Systemic / Q000209:etiology; D008222:Lymphokines / Q000276:immunology; D008230:Lymphomatoid Granulomatosis / Q000209:etiology*; D008264:Macrophages / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D011650:Pulmonary Alveoli / Q000166:cytology; D012595:Scleroderma, Systemic / Q000209:etiology; D012756:Sheep; D013601:T-Lymphocytes / Q000276:immunology; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000209:etiology*
D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex; D008222:Lymphokines; D007073:Immunoglobulin E