Toxicity of mitomycin C and anti-intoxication by fumaric acid in liver and kidney cellular fine structure.
The previous study indicated that the toxic symptoms in ICR mice given two ip injections of 4 mg/kg of mitomycin C at an interval of 48 hr were reduced by the concurrent administration of 40 mg/kg of fumaric acid. In the present study, are described the changes of subcellular components and organella in the liver and kidney at 4 days after the 2nd injection. The liver treated with mitomycin C showed perinuclear irregularity, aggregation of chromatins, and abnormal cytoplasmic organella (e.g., swelling of mitochondria and dilatation of rough endoplasmic reticulum). Focal localization of rough endoplasmic reticulum was noted. The concurrent administration of fumaric acid reduced the incidence of such deleterious changes. Increases in the number of nucleoli and normal cytoplasmic organella were evident. The kidney treated with mitomycin C showed decrease of chromatins and edematous nuclear matrix. The cytoplasmic organella were swollen. The action of fumaric acid against mitomycin C intoxication was more apparent in the kidney. Chromatins and nucleoli developed well and other subcellular organella appeared completely normal.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000037:antagonists & inhibitors / Q000633:toxicity*; D000931:Antidotes; D005650:Fumarates / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000648:ultrastructure; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D051379:Mice; D008813:Mice, Inbred ICR; D016685:Mitomycin; D008937:Mitomycins / Q000037:antagonists & inhibitors / Q000633:toxicity*
D000903:Antibiotics, Antineoplastic; D000931:Antidotes; D005650:Fumarates; D008937:Mitomycins; D016685:Mitomycin