Tumor-localizing components of the porphyrin preparation hematoporphyrin derivative.
Synthetic and analytical approaches were used to characterize the tumor-localizing components of the porphyrin preparation, hematoporphyrin derivative. From studies involving aqueous and nonaqueous gel exclusion and reverse-phase chromatography, we conclude that localization is mediated by hematoporphyrin derivative components which are among the most hydrophobic in the preparation. This apparent hydrophobicity may derive from hydrogen-bonding phenomena, rather than from absence of hydrophilic functional groups.
D000818:Animals; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006415:Hematoporphyrins / Q000032:analysis / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D051379:Mice; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000378:metabolism*; D013053:Spectrophotometry
D006415:Hematoporphyrins