Mode of action of Myxococcus xanthus antibiotic TA.
Antibiotic TA inhibited incorporation of diaminopimelic acid and uridine diphosphate-N-acetylglucosamine into Escherichia coli cell walls without altering the ratio of cross-linked to uncross-linked peptidoglycan. Formation of the lipid intermediate was not blocked by TA, suggesting that TA interferes with polymerization of the lipid-disaccharide-pentapeptide.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002473:Cell Wall / Q000378:metabolism; D003960:Diaminopimelic Acid / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism; D018942:Macrolides; D009231:Myxococcales / Q000378:metabolism; D010457:Peptidoglycan / Q000378:metabolism; D014537:Uridine Diphosphate N-Acetylglucosamine / Q000378:metabolism
D000900:Anti-Bacterial Agents; D018942:Macrolides; D010457:Peptidoglycan; D014537:Uridine Diphosphate N-Acetylglucosamine; D003960:Diaminopimelic Acid; C035536:Myxococcus xanthus antibiotic TA