Red blood cell targeting to collagen-coated surfaces.
The interaction of human red blood cells carrying antihuman collagen antibody with collagen-coated surfaces was studied. Avidin was used as bifunctional crosslinking agent for the attachment of antibody to the red blood cell surface. Antibody-carrying red blood cells efficiently and specifically bound to collagen-coated surface covering a significant part of the surface. The components of normal blood had an insignificant effect on red blood cell binding. A model of drug targeting to the injured sites(s) of blood vessel wall is proposed.
D000918:Antibody Specificity; D001360:Avidin; D001710:Biotin; D055598:Chemical Phenomena; D002621:Chemistry; D003094:Collagen / Q000276:immunology*; D004912:Erythrocytes; D006801:Humans
D001360:Avidin; D001710:Biotin; D003094:Collagen