[Simultaneous diffusion of inositol and mannitol in the rat brain].
The diffusion of both inositol and mannitol has been determined simultaneously by the integral bolus method in rat brain. The permeability constant (Kin) of inositol averaged 0.27 +/- 0.02 ml X (100 g)-1 X min-1 or 4 X 10(-7) cm X s-1 at a cerebral capillary surface area of 100 cm2 x g-1. The permeability of mannitol was 0.08 +/- 0.01 ml X (100 g)-1. min-1 or 1 X 10(-7) cm X s-1. Neither glucose nor galactose affected the inositol permeability. Hypoglycemia increased somewhat the Km value for mannitol. The basal ganglia showed an increase Km for both substrates as compared with those obtained for cortex, temporal and parietal tissues.
D000818:Animals; D001479:Basal Ganglia / Q000378:metabolism; D001693:Biological Transport, Active; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D004058:Diffusion; D007294:Inositol / Q000378:metabolism*; D008353:Mannitol / Q000378:metabolism*; D010296:Parietal Lobe / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013702:Temporal Lobe / Q000378:metabolism
D008353:Mannitol; D007294:Inositol
Difusión simultánea de inositol y manitol en cerebro de rata.