title: Trends in serum uric acid levels 1961--1980.
abstract: Uric acid levels of adult male volunteers in a longitudinal study of human aging rose steadily between 1961 and 1978. In the 1,141 men with 3 serial physical examinations, who developed no diseases and who took no drugs known to affect uric acid levels, levels rose from means below 5.5 mg/dl in 1961--1963 to means above 6.5 mg/dl in 1975--1978. The best predictor of a longitudinal increase in uric acid level was a gain in weight, but this, and other significant predictors, explained only a small portion of the increase in this population. Preliminary data available from a fourth examination indicate that the rising trend has leveled off.
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D000428:Alcohol Drinking; D001835:Body Weight; D004032:Diet; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014481:United States; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid