Antimycotic azoles. 6. Synthesis and antifungal properties of terconazole, a novel triazole ketal.
The preparation and antifungal properties of cis-1-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1, 3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)piperazine are reported. Terconazole has a high topical in vivo activity against vaginal candidosis in rats and against dermatophytosis in guinea pigs.
D000818:Animals; D000935:Antifungal Agents; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy; D003881:Dermatomycoses / Q000188:drug therapy; D005260:Female; D006168:Guinea Pigs; D051381:Rats; D014230:Triazoles / Q000138:chemical synthesis / Q000627:therapeutic use*
D000935:Antifungal Agents; D014230:Triazoles; C037815:terconazole