Immunological studies with sulpholipids of mycobacteria.
Antibodies to sulpholipids of mycobacteria were produced in rabbits when injected as sulpholipid-MBSA complexes and were detected by kaolin agglutination and double diffusion techniques. Sulpholipid antibodies did not cross react with any other lipids of mycobacteria except cord-factor. The antigenicity of sulpholipids appears to be due to alpha-D-trehalose and sulphate groups. Guinea pigs immunized with sulpholipid-MBSA complexes showed partial protection against tuberculous infection with M. tuberculosis H37Rv, as revealed by mortality rate and score of lesions.
D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D000937:Antigen-Antibody Reactions; D000942:Antigens, Bacterial / Q000276:immunology*; D003429:Cross Reactions; D006168:Guinea Pigs; D007114:Immunization; D008055:Lipids / Q000276:immunology*; D009159:Mycobacteriaceae / Q000276:immunology*; D009163:Mycobacterium bovis / Q000276:immunology; D009168:Mycobacterium phlei / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000276:immunology; D014376:Tuberculosis / Q000517:prevention & control
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D008055:Lipids; C015518:sulfolipids