title: Potential radiopharmaceuticals for the detection of ocular melanoma. Part I. 5-iodo-2-thiouracil derivatives.
abstract: The tissue distribution of a number of 5-[131I]-iodo-2-thiouracil derivatives was measured in Syrian golden hamsters with Greene melanoma. These compounds were rapidly (in less than 1 h) distributed in all tissues, while in most tissues fast elimination (T1/2 1-3 h) was observed. Because of retention of the 131I activity in the tumour, high tumour/non-tumour tissue ratios were found (e.g. tumour/eye 2.3-10, tumour/skin 1.5-3) suggesting that some of these compounds might be used as melanoma delineating agents, when labelled with 123I.
mesh_terms: D000818:Animals; D006224:Cricetinae; D005134:Eye Neoplasms / Q000000981:diagnostic imaging*; D007457:Iodine Radioisotopes; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000378:metabolism; D008647:Mesocricetus; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism; D011877:Radionuclide Imaging; D013889:Thiouracil / Q000031:analogs & derivatives* / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D007457:Iodine Radioisotopes; D013889:Thiouracil; C036667:iodothiouracil