title: The Frey syndrome: a simple, effective treatment.
abstract: The benign but socially embarrassing problem of gustatory sweating and flushing (Frey syndrome) has been studied in the past in search of a simple but effective treatment. Twenty-two patients participated in clinical trials of glycopyrrolate on an investigational basis, 17 of which have been followed up for four to five years. Double-blind comparisons of the efficacy and side effects of topical scopolamine (solution and cream) and glycopyrrolate (roll-on lotion, solution, and cream) are also presented. The use of 1% glycopyrrolate roll-on lotion and cream were associated with an average of three days of complete control of gustatory sweating and a remarkably low incidence of side effects.
mesh_terms: D000287:Administration, Topical; D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D006024:Glycopyrrolate / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D010306:Parotid Gland / Q000601:surgery; D011183:Postoperative Complications; D011759:Pyrrolidines / Q000008:administration & dosage*; D012601:Scopolamine / Q000627:therapeutic use; D013547:Sweating, Gustatory / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D011759:Pyrrolidines; D012601:Scopolamine; D006024:Glycopyrrolate