Theophylline-induced potentiation of the antinociceptive action of baclofen.
1--Theophylline (35, 50 mg/kg) potentiated the antinociceptive action of intraperitoneally administered baclofen in the tail flick and hot plate tests. Potentiation was most marked when the pretreatment time was 1 h, but some potentiation was still apparent following a 2 h pretreatment. 2--Theophylline alone (50 mg/kg) produced only slight alterations in reaction latency in the two tests. 3--When baclofen was applied directly into the spinal subarachnoid space, a 1 h pretreatment with theophylline produced minimal effects, but a 2 h pretreatment produced an increase in the antinociceptive action of baclofen. 4--These results suggest that theophylline can potentiate the antinociceptive action of baclofen by actions at both supraspinal and spinal sites.
D000700:Analgesics; D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology; D004357:Drug Synergism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D013806:Theophylline / Q000494:pharmacology*
D000700:Analgesics; D002110:Caffeine; D013806:Theophylline; D001418:Baclofen