Absence of the pituitary gland in a case of congenital sacral agenesis.
We report for the first time the combination of congenital sacral agenesis and congenital absence of the pituitary gland. This rare association is described in a baby born to a diabetic mother. The baby died at the age of 11 weeks after a cardiorespiratory collapse. The findings at necropsy, which included unusual neurological and visceral anomalies, are reported. We draw attention to the increasing evidence that maternal diabetes is a factor in producing foetal malformations.
D000015:Abnormalities, Multiple / Q000209:etiology; D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008161:Lumbosacral Region / Q000000981:diagnostic imaging; D010902:Pituitary Gland / Q000002:abnormalities*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000150:complications; D011859:Radiography; D012447:Sacrum / Q000002:abnormalities*