Synergistic effect of estrogen and androgen on induction of uterine thymidine kinase activities in immature rats.
Estradiol-17 beta induced a significant increase in the uterine thymidine kinase activity with a characteristic isozyme pattern 30 h after injection into immature rats. Testosterone propionate also revealed a similar increase. Following combined injection of estradiol-17 beta and testosterone propionate, the overall and separate isozyme activities of thymidine kinase increased to nearly the total amount of those when each hormone was injected separately.
D000818:Animals; D004357:Drug Synergism; D004790:Enzyme Induction; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007527:Isoenzymes / Q000235:genetics; D007700:Kinetics; D051381:Rats; D012741:Sexual Maturation; D013739:Testosterone / Q000494:pharmacology*; D013937:Thymidine Kinase / Q000235:genetics* / Q000378:metabolism; D014599:Uterus / Q000187:drug effects / Q000201:enzymology*
D007527:Isoenzymes; D013739:Testosterone; D004958:Estradiol; D013937:Thymidine Kinase