title: Femoral artery flow and pain during lumbar aortography: comparison of ionic and non-ionic contrast media.
abstract: A method is described for non-invasively measuring the increase in lower limb blood flow during transfemoral lumbar aortography. Flow measurements were made using a continuous wave Doppler-shift ultrasound transducer placed over the contralateral femoral artery. The effect of the non-ionic contrast medium B15000 (Iopamidol), conventional contrast medium (Urografin 370) and Urografin 370 plus Lignocaine were compared in a double-blind trial. All three produced an increase in flow which reached a peak between 12 and 45 s after injection. The peak flow following Iopamidol was significantly lower than that from both Urografin 370 alone and with addition of Lignocaine. There was a difference of lesser degree between Urografin 370 plus Lignocaine and Urografin 370 alone; however, this was not statistically significant. The subjective assessments of pain and patient 'discomfort' paralleled these objective flow measurements.
mesh_terms: D000368:Aged; D001027:Aortography / Q000009:adverse effects / Q000379:methods*; D003287:Contrast Media / Q000009:adverse effects / Q000494:pharmacology*; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging; D006801:Humans; D007479:Iopamidol; D007483:Iothalamic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D008012:Lidocaine / Q000009:adverse effects / Q000494:pharmacology; D008161:Lumbosacral Region; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D010146:Pain / Q000209:etiology; D012039:Regional Blood Flow / Q000187:drug effects
chemical_list: D003287:Contrast Media; D003973:Diatrizoate; D007483:Iothalamic Acid; D003974:Diatrizoate Meglumine; D008012:Lidocaine; D007479:Iopamidol