The effect of ZIMET 3164 and ZIMET 3393 on phagocytosis in Tetrahymena pyriformis GL.
Tetrahymena pyriformis GL is a suitable model to study the influence on phagocytotic activity of two membrane-stabilizing benzimidazole nitrogen mustard derivative, ZIMET 3164 and ZIMET 3393 (cytostasan). Treatment by both compounds causes a gradual inhibition of food vacuole formation dependent on the concentrations used. Complete cessation of phagocytosis is observed by 5 micrograms/ml ZIMET 3164 and 50 micrograms/ml ZIMET 3393. Additionally, disturbances of ciliary movement including immobilization and changes of cell shape are induced. The cells resume food vacuole formation and ciliary movement after being rinsed with control solution. The results correspond well with those described recently in mammalian mononuclear phagocytes.
D000818:Animals; D000069461:Bendamustine Hydrochloride; D001562:Benzimidazoles / Q000494:pharmacology*; D002923:Cilia / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects*; D013769:Tetrahymena pyriformis / Q000187:drug effects / Q000502:physiology*; D014617:Vacuoles / Q000187:drug effects
D001562:Benzimidazoles; D009588:Nitrogen Mustard Compounds; C022820:IMET 3146; D000069461:Bendamustine Hydrochloride