The effect of neurotensin on food consumption in the rat.
The effect of neurotensin on feeding behavior were studied in rats. Intracerebroventricular administration of neurotensin (3.3-30 micrograms) produced a dose-related decrease in food intake in 24 h food deprived rats. Acute intracerebroventricular injection of neurotensin (30 micrograms) shortly after the ingestion of a novel flavor did not produce a flavor aversion during testing 48 h later, suggesting that reduction of food intake by low doses of centrally administered neurotensin is not related to a conditioned taste aversion. Intracerebroventricularly administered thyrotropin-releasing hormone (2.2 micrograms) also inhibited food intake and appeared to attenuate slightly the inhibition of food intake induced by 10 micrograms neurotensin.
D000818:Animals; D004435:Eating / Q000187:drug effects*; D005508:Food Deprivation / Q000502:physiology; D006185:Habituation, Psychophysiologic; D007276:Injections, Intraventricular; D008094:Lithium / Q000494:pharmacology; D008297:Male; D009496:Neurotensin / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste / Q000187:drug effects; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D009496:Neurotensin; D013973:Thyrotropin-Releasing Hormone; D008094:Lithium