title: The mutagenic activity of nickel in Corynebacterium sp.
abstract: Ni2+ ions exhibit a mutagenic effect on the bacterial strain Corynebacterium sp. 887 (hom). The mutagenic activity of the divalent nickel was demonstrated by both the simplified fluctuation test and the so-called clone method. However, when using the clone method and low nickel concentrations the frequency of induced mutants decreases considerably as compared with the control and Ni2+ ions have an antimutagenic effect under these conditions.
mesh_terms: D003352:Corynebacterium / Q000187:drug effects / Q000235:genetics*; D004305:Dose-Response Relationship, Drug; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects*; D009532:Nickel / Q000494:pharmacology*
chemical_list: D009532:Nickel