[Protective action of antioxidants and microsomal monooxygenase inducers in ischemic and reoxygenation damage to the liver].
One-hour ischemia followed by rat liver reoxygenation brings about the accumulation of endogenous products of lipid peroxidation (LPO) and deterioration of the monooxygenase system (the drop of cytochrome P-450 content, amidopyrine N-demethylase and NADP X H cytochrome reductase activity). Application of the antioxidant ionol inhibited LPO and protected the monooxygenase system from reoxygenation but not from ischemic injuries. Phenobarbital alone and combined with ionol did not protect the monooxygenase system from ischemic and reoxygenation injuries but provided the retention of high absolute indicators of the system. Ionol and its combination with phenobarbital also increased the survival of rats with ischemized liver.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D007511:Ischemia / Q000201:enzymology*; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000098:blood supply*; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010101:Oxygen Consumption / Q000187:drug effects*; D010105:Oxygenases / Q000096:biosynthesis*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000975:Antioxidants; D008054:Lipid Peroxides; D002084:Butylated Hydroxytoluene; D010105:Oxygenases; D010634:Phenobarbital
Zashchitnoe deĭstvie antioksidantov i induktorov mikrosomnykh monooksigenaz pri ischemicheskom i reoksigenatsionnom povrezhdeniiakh pecheni.