title: Studies on tomaymycin. II. Total syntheses of the antitumor antibiotics, E-and Z-tomaymycins.
abstract: The total syntheses of naturally occurring E-tomaymycin (1E) and its olefinic geometrical isomer, Z-tomaymycin (1Z) are described. The Z-isomer was found to have the same anti-bacterial activity as E-isomer (1E).
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D001570:Benzodiazepinones / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism
chemical_list: D000903:Antibiotics, Antineoplastic; D001570:Benzodiazepinones; C003619:tomaymycin