Cytostatic effects of activated macrophages on tumor target cells: inhibition of cytotoxic action of ARA-C.
Studies carried out to explore further the cytotoxic effects of activated macrophages from mice treated with Corynebacterium parvum revealed that their effect on the EMT-6 line of tumor target cells was limited solely to cytostasis with no evidence of a cytocidal effect. In additional studies, the cytostatic effects of activated macrophages markedly reduced the cytotoxic effects of the chemotherapeutic agent cytosine arabinoside on EMT-6 target cells.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003561:Cytarabine / Q000633:toxicity*; D005260:Female; D008262:Macrophage Activation / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D011425:Propionibacterium acnes / Q000276:immunology; D014407:Tumor Cells, Cultured / Q000276:immunology*
D003561:Cytarabine