Methyl-beta-carboline-induced convulsions are antagonized by Ro 15-1788 and by propyl-beta-carboline.
Injected i.v. into baboons, Ro 15-1788 (a benzodiazepine antagonist) and propyl-beta-carboline-3-carboxylate did not modify either the behavior or the electroencephalogram at doses up to 2 mg/kg. Methyl-beta-carboline-3-carboxylate is a potent convulsant at doses of 20 micrograms/kg in photosensitive baboons and 100 micrograms/kg in non-photosensitive baboons. These convulsive doses of methyl-beta-carboline-3-carboxylate are effectively antagonized by 0.5 mg/kg of Ro 15-1788 and also by 2 mg/kg of propyl-beta-carboline-3-carboxylate.
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D002243:Carbolines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D005442:Flumazenil; D007211:Indoles / Q000494:pharmacology*; D010215:Papio; D010787:Photosensitivity Disorders / Q000503:physiopathology; D012640:Seizures / Q000139:chemically induced* / Q000517:prevention & control; D013997:Time Factors
D001570:Benzodiazepinones; D002243:Carbolines; D007211:Indoles; C026072:1-methyl-beta-carboline-3-carboxylic acid; D005442:Flumazenil; C028585:propyl beta-carboline-3-carboxylate; D003975:Diazepam