title: Tissue distribution of lead in the neonatal rat exposed to multiple doses of lead acetate.
abstract: The tissue distribution of lead (Pb) was examined in the neonatal rat intragastrically administered lead acetate (50 mg/kg, containing 210Pb) beginning on d 6 postpartum and thereafter at 3-d intervals to d 18. A time-dependent pattern of uptake was observed in bone, kidney, liver, and brain, while stomach, lung, heart, and spleen had no accumulation of Pb. The highest concentration of Pb at d 21 was detected in bone, and the least amount was found in blood and brain. Body weight was not significantly affected by the level of Pb exposure employed.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D005260:Female; D007854:Lead / Q000009:adverse effects / Q000032:analysis* / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D009942:Organometallic Compounds; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D009942:Organometallic Compounds; D007854:Lead; C008261:lead acetate