Heat(40 degrees C)-induced polypeptides in human embryonic fibroblasts.
The synthesis of 3 polypeptides with molecular weights of 103-, 80- and 78-kdalton (K) was dramatically accelerated when the cultures of human embryonic fibroblasts were transferred from 37 to 40 degrees C. The induction of these polypeptides was not observed if actinomycin D was added to the cultures at the beginning of the rising of the temperature, indicating that this response may be mediated by increased transcription of their messenger RNA.
D005260:Female; D005347:Fibroblasts / Q000378:metabolism*; D006358:Hot Temperature; D006801:Humans; D008970:Molecular Weight; D010452:Peptide Biosynthesis; D011247:Pregnancy; D013997:Time Factors