Generation of angiotensin I by human chorion-decidua in vitro.
An angiotensin I-like substance has been detected in media after incubation of human chorion-decidua in vitro. The substance was identified as angiotensin I by gel filtration, ion exchange chromatography, and a specific antiserum to angiotensin I. The presence of angiotensin I in these incubates indicates that renin substrate may be either stored or synthesized by the tissue. The levels of angiotensin I produced during incubation were greater than could be explained by the action of renin on plasma substrate since the major part of the chorion-decidua is avascular. Previously chorion-decidua has been shown to contain large amounts of renin and to be capable of synthesizing both active and inactive forms of the enzyme in vitro; however, renin substrate has not been described in this tissue.
D000803:Angiotensin I / Q000302:isolation & purification / Q000378:metabolism*; D000809:Angiotensins / Q000378:metabolism*; D002823:Chorion / Q000378:metabolism*; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D003470:Culture Media; D003656:Decidua / Q000378:metabolism*; D005260:Female; D006801:Humans; D011247:Pregnancy
D000809:Angiotensins; D003470:Culture Media; D000803:Angiotensin I