[Calcium-dependent liberation of gamma-hydroxybutyrate after depolarization of rat brain slices].
The release of gamma-hydroxybutyrate from preloaded Rat brain striatal slices was investigated. Potassium induced depolarisation caused an efflux of gamma-hydroxybutyrate in the incubation medium. This release is significantly decreased by a calcium free medium, containing magnesium salt and EGTA. Taking into account our previous results concerning synthesis, uptake and binding of gamma-hydroxybutyrate, this calcium-dependent release strongly suggest a possible role of gamma-hydroxybutyrate in neurotransmission in the C.N.S.
D000818:Animals; D001921:Brain / Q000187:drug effects; D002118:Calcium / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D004533:Egtazic Acid / Q000494:pharmacology; D006885:Hydroxybutyrates / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008274:Magnesium / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012978:Sodium Oxybate / Q000378:metabolism*
D006885:Hydroxybutyrates; D004533:Egtazic Acid; D012978:Sodium Oxybate; D008274:Magnesium; D002118:Calcium
Libération de gamma-hydroxybutyrate calcium-dépendante après dépolarisation de coupes de cerveau de Rat.