The effects of disodium cromoglycate and beclomethasone dipropionate on the immediate response of the nasal mucosa to allergen challenge.
This study deals with the comparative investigation of the protective effects of disodium cromoglycate (DSCG) Rynacrom, Intal and beclomethasone dipropionate aerosol (BDA); Aldecin Beconase on the immediate nasal mucosa response to allergen challenge due to the immediate hypersensitivity (Type I allergy) in 50 patients suffering from allergic rhinitis. DSCG demonstrated distinct protective effects on the immediate nasal mucosa response to allergen challenge in all patients investigated, while BDA failed to demonstrate any protective effects on the immediate nasal mucosa response to allergen challenge in any of the patients studied.
D000281:Administration, Intranasal; D000485:Allergens / Q000008:administration & dosage*; D001507:Beclomethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis*; D009297:Nasal Mucosa / Q000187:drug effects / Q000276:immunology; D009299:Nasal Provocation Tests / Q000379:methods*; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis; D012882:Skin Tests
D000485:Allergens; D001507:Beclomethasone; D004205:Cromolyn Sodium