Effect of follicle-stimulating hormone (FSH) on radiation-induced chromosomal aberrations in mouse germ cells and Chinese hamster cells in vitro.
Earlier observations on the induction by X-rays of reciprocal translactions in stem-cell spermatogonia of the rhesus monkey have established a correlation between the level of follicle-stimulating hormone (FSH) in blood at the moment of irradiation and the final recovery of translocations (van Buul, 1980). In the present study, FSH treatment of mice did not induce chromosomal aberrations in bone-marrow cells or stem-cell spermatogonia, nor did it change the radiosensitivity of stem-cell spermatogonia for the induction of chromosomal translocations. Experiments in vitro with Chinese hamster ovary cells (CHO), however, showed a clear radiosensitizing effect of FSH on the induction of structural chromosomal aberrations.
D000818:Animals; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D004912:Erythrocytes / Q000528:radiation effects; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010053:Ovary / Q000528:radiation effects; D011838:Radiation-Sensitizing Agents; D012854:Sister Chromatid Exchange / Q000528:radiation effects; D013093:Spermatogonia / Q000528:radiation effects; D014178:Translocation, Genetic / Q000528:radiation effects
D011838:Radiation-Sensitizing Agents; D005640:Follicle Stimulating Hormone