Immunohistochemical studies of cell differentiation in a juxtaglomerular tumor.
A renal tumor removed from a 29-year-old woman, who recently had had onset of primary hypertension, showed the histologic and ultrastructural features of a renin-secretory juxtaglomerular cell tumor. The expression of Factor VIII-related antigen (FVIII-RAG) was evaluated to identify endothelial differentiation of tumor cells in this lesion. Control tissue and vessels within the tumor showed normal expression of FVIII-RAG, but tumor cells as well as normal juxtaglomerular cells showed no localization of this antigen, which suggests the nonendothelial nature of these specialized cells.
D000328:Adult; D000941:Antigens / Q000032:analysis*; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D005169:Factor VIII / Q000032:analysis / Q000276:immunology*; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007606:Juxtaglomerular Apparatus; D007680:Kidney Neoplasms / Q000032:analysis* / Q000276:immunology / Q000473:pathology; D009384:Paraneoplastic Endocrine Syndromes / Q000209:etiology / Q000276:immunology; D012083:Renin / Q000378:metabolism*; D014841:von Willebrand Factor
D000941:Antigens; D014841:von Willebrand Factor; D005169:Factor VIII; D012083:Renin