Effect of oestradiol on RNA polymerase of foetal guinea-pig uterus.
The administration of 10 micrograms oestradiol to the foetus of the guinea-pig (55-65 days of gestation) causes an increase in RNA polymerase I and II activities in the nuclei of the foetal uterus. RNA polymerase I activity increased by 4 times above the control values after 120 min (p less than 0.001) whereas RNA polymerase II activity increased more rapidly, reaching 2.5 times the control levels at 30 min and 4 times by 120 min after treatment (p less than 0.01).
D000818:Animals; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D007700:Kinetics; D012318:RNA Polymerase I / Q000378:metabolism*; D012319:RNA Polymerase II / Q000378:metabolism*; D014599:Uterus / Q000187:drug effects / Q000196:embryology* / Q000201:enzymology
D004958:Estradiol; D012319:RNA Polymerase II; D012321:DNA-Directed RNA Polymerases; D012318:RNA Polymerase I