title: [Wernicke's encephalopathy in chronic gastropancreatic disease with pyloric stenosis].
abstract: The acute symptomatology of Wernicke's syndrome was observed in a 17-year-old female patient and a 48-year-old male patient. They were both affected by chronic gastropancreatic disease with pyloric stenosis and showed already subclinical thiamine deficiency. Symptoms occurred within 4 weeks of an infusion regime rich in carbohydrates. Parenteral administration of high doses of thiamine (200 mg/d and 360 mg/d) led to clear-cut regression of symptoms. Due to the unfavourable prognosis of Wernicke's encephalopathy prophylactic administration of thiamine in a daily dosage of 50-100 mg is recommended in patients with chronic intestinal disease and parenteral nutrition.
mesh_terms: D000293:Adolescent; D002908:Chronic Disease; D004040:Dietary Carbohydrates; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000150:complications*; D010288:Parenteral Nutrition; D011707:Pyloric Stenosis / Q000150:complications*; D013272:Stomach Diseases / Q000150:complications*; D013831:Thiamine / Q000627:therapeutic use; D014899:Wernicke Encephalopathy / Q000188:drug therapy / Q000209:etiology*
chemical_list: D004040:Dietary Carbohydrates; D013831:Thiamine
vernacular_title: Wernicke-Enzephalopathie bei chronischer gastropankreatischer erkrankung mit Pylorusstenose.