Cimetidine-associated thrombocytopenia.
A case of thrombocytopenia associated with cimetidine administration in a 65-year-old white female with recurrent adenocarcinoma is reported. Her platelet count fell from 273 000/mm3 to 35 000/mm3 after cimetidine therapy was started. Upon discontinuation of cimetidine, the platelet count increased to 164 000/mm3. Later in her hospital course, the patient again received cimetidine and her platelet count fell to 37 000/mm3. The patient was never leukopenic during her hospitalization. This is the only reported case of thrombocytopenia in the absence of leukopenia that is documented by a rechallenge with cimetidine.
D000368:Aged; D002927:Cimetidine / Q000009:adverse effects*; D005260:Female; D006146:Guanidines / Q000009:adverse effects*; D006801:Humans; D010976:Platelet Count; D013921:Thrombocytopenia / Q000139:chemically induced*; D013997:Time Factors
D006146:Guanidines; D002927:Cimetidine