3-amino-3-demethoxyfortimicin A and the C-2 epimeric-2-amino-3-O-demethyl-2-deoxyfortimicins A.
Selective reactions of 3-O-demethyl-3-O-methanesulfonyl-4-N, 5-O-methylenefortimicin derivatives have been used as the key steps in the syntheses of 3-amino-3-demethoxyfortimicin A and the C-2 epimeric 2-amino-3-O-demethyl-2-deoxyfortimicins A. In vitro antibacterial activities of the new fortimicin derivatives are reported.
D000617:Aminoglycosides / Q000138:chemical synthesis / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C037747:3-amino-3-demethoxyfortimicin A; C037748:2-amino-3-O-demethyl-2-deoxyfortimicin A