Ocular copper deposition associated with pulmonary carcinoma, IgG monoclonal gammopathy and hypercupremia. A clinicopathologic correlation.
Hypercupremia with central deposition of copper in Descemet's membrane and lens capsule has been reported previously in lymphoproliferative disorders in two cases. A 60-year-old white man presented with visual acuity loss and was found to have an iridescent brown corneal and lenticular discoloration. Laboratory investigation revealed hypercupremia secondary to a poorly differentiated adenocarcinoma of the lung. Presence of copper in the eye was confirmed by specific atomic absorption spectra and histochemical stains of ocular tissue. This appears to be the first report of a carcinoma with associated hypercupremia presenting initially with ocular copper deposition.
D000230:Adenocarcinoma / Q000175:diagnosis / Q000378:metabolism*; D000911:Antibodies, Monoclonal / Q000032:analysis*; D003300:Copper / Q000097:blood / Q000378:metabolism*; D003886:Descemet Membrane / Q000378:metabolism*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000175:diagnosis*; D007074:Immunoglobulin G / Q000032:analysis*; D007903:Lens Capsule, Crystalline / Q000378:metabolism* / Q000648:ultrastructure; D007908:Lens, Crystalline / Q000378:metabolism*; D008175:Lung Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged
D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D003300:Copper