AET reduces the frequency of micronuclei in bone marrow cells of mice exposed to gamma radiation.
The purpose of this paper was to determine whether or not a radioprotective agent which binds to DNA and inhibits DNA damage could also provide protection against radiation-induced micronuclei. Male mice were injected intraperitoneally with such an agent, 2-aminoethylisothiouronium bromide hydrobromide (AET), or its solvent 15 min prior to a single 10-min exposure to 60Co gamma rays delivered at various dose rates. Animals were killed 24 hr after irradiation and examined for the frequency of polychromatic erythrocytes containing micronuclei. The results showed a significant dose response to the irradiation for both treatments and a significant reduction in the frequency of micronucleated cells in the mice receiving the radioprotective agent.
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects* / Q000648:ultrastructure; D002467:Cell Nucleus / Q000528:radiation effects*; D004247:DNA / Q000378:metabolism / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004912:Erythrocytes / Q000528:radiation effects / Q000648:ultrastructure; D005720:Gamma Rays; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D000338:beta-Aminoethyl Isothiourea / Q000494:pharmacology*
D000338:beta-Aminoethyl Isothiourea; D004247:DNA