[Preoperative OMF therapy for gastric cancer--examination of macroscopical effect in comparison with histological effect].
OMF treatment consisting of perifocal administration of OK-432 associated with treatment with MMC and 5-FU was applied for 14 lesions of 13 cases including 1 case of multiple cancer. The results obtained were examined macroscopically and histologically. Macroscopic findings were rated as "good" in 5 lesions (35.8%), "fair" in 8 lesions (57.1%) and "poor" in 1 case. There was no significant difference according to a histologic type. Histologic efficacy was assessed as "++" for 6 lesions (43%), "+" for 6 lesions (43%) and "-" for 2 lesions (14%), suggesting a tendency that higher histologic efficacy be obtained for lesions with a lower degree of differentiation. Taking "+" or higher histologically as "effective", the efficacy rate was approximately 86%. When the macroscopic results were compared with histologic results based on a criteria for assessment established by our group, it was found that the macroscopic efficacy tended to be associated with the histologic efficacy with a consistency rate of approximately 71%.
D000328:Adult; D000368:Aged; D001688:Biological Products / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage*; D010844:Picibanil / Q000008:administration & dosage*; D011300:Preoperative Care; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology*
D001688:Biological Products; D008937:Mitomycins; D010844:Picibanil; D016685:Mitomycin; D005472:Fluorouracil