Skin carcinogenesis and promoter binding characteristics in different mouse strains.
The sensitivity of various mouse strains to skin carcinogenesis has been investigated in two ways; (i) by comparing carcinogenesis induced by treatments involving both the application of tumour promoters and the application of single or multiple doses of a carcinogen, and (ii) by comparing the binding characteristics of the tumour promoter [3H]phorbol-12,13-dibutyrate to particulate skin preparations. The mouse strains tested were Swiss albino, Balb/c, C3H, LACA and AKR/J. Although some differences were apparent, Swiss albino, LACA and C3H mice were generally sensitive to skin carcinogenesis by both benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene, either with or without promotion with croton oil. AKR/J mice were sensitive to both carcinogens with promotion but relatively insensitive in the absence of promotion. Balb/c mice had low sensitivity except when exposed to repeated low doses of benzo[a]pyrene. The [3H]phorbol-12,13-dibutyrate binding characteristics of particulate skin preparations from all strains were indistinguishable.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology; D000818:Animals; D002273:Carcinogens / Q000378:metabolism*; D003436:Croton Oil / Q000494:pharmacology; D005260:Female; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010634:Phenobarbital / Q000494:pharmacology; D012377:Rodentia; D012878:Skin Neoplasms; D013045:Species Specificity; D013997:Time Factors
D002273:Carcinogens; D008748:Methylcholanthrene; D015127:9,10-Dimethyl-1,2-benzanthracene; D003436:Croton Oil; D010634:Phenobarbital