Proglumide: selective antagonism of excitatory effects of cholecystokinin in central nervous system.
Extracellular single-unit recording techniques were used to test the ability of proglumide to block cholecystokinin-induced excitation of rat midbrain dopaminergic neurons and dopamine-sensitive prefrontal cortex cells. Intravenous and iontophoretic proglumide administration consistently blocked cholecystokinin-induced excitations while having no effect on glutamic acid-induced increases in activity. This selective blockade of central cholecystokinin effects by proglumide suggests that this drug may be valuable for studying the possible role of cholecystokinin as a neurotransmitter or neuromodulator in the central nervous system.
D000818:Animals; D001921:Brain / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology; D002766:Cholecystokinin / Q000494:pharmacology*; D004336:Drug Antagonism; D005973:Glutamine / Q000031:analogs & derivatives*; D008297:Male; D008636:Mesencephalon / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011377:Proglumide / Q000494:pharmacology*; D051381:Rats
D005973:Glutamine; D002766:Cholecystokinin; D011377:Proglumide