Adverse effects of combined propranolol and chlorpromazine therapy.
The authors describe a woman with chronic schizophrenia who experienced delirium, grand mal seizure, and photosensitivity after the addition of propranolol to her neuroleptic regimen. The pharmacokinetic synergism of this combination may be hazardous for some patients.
D000328:Adult; D002746:Chlorpromazine / Q000009:adverse effects*; D003693:Delirium / Q000139:chemically induced*; D004359:Drug Therapy, Combination; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced; D005260:Female; D006801:Humans; D010787:Photosensitivity Disorders / Q000139:chemically induced; D011433:Propranolol / Q000009:adverse effects*; D011605:Psychoses, Substance-Induced / Q000209:etiology; D012563:Schizophrenia, Paranoid / Q000188:drug therapy / Q000523:psychology
D011433:Propranolol; D002746:Chlorpromazine