Essential thrombocythemia: a clonal disorder of hematopoietic stem cell.
We studied 5 patients with essential thrombocythemia utilizing glucose-6-phosphate dehydrogenase (G-6-PD) enzyme as a cell marker for determining clonality. One of the patients was found to be heterozygous for isoenzymes B and A in the nonhaemopoietic tissues such as fibroblasts, but manifested only isoenzyme type B in the erythrocytes, neutrophils, and platelets. Our studies support the concept that essential thrombocythemia is a clonal disorder arising in a multipotent stem cell.
D001792:Blood Platelets / Q000201:enzymology; D002999:Clone Cells / Q000201:enzymology / Q000473:pathology*; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005347:Fibroblasts / Q000201:enzymology; D005954:Glucosephosphate Dehydrogenase / Q000032:analysis / Q000235:genetics; D006098:Granulocytes / Q000201:enzymology; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007527:Isoenzymes / Q000032:analysis / Q000235:genetics; D008875:Middle Aged; D013922:Thrombocytosis / Q000201:enzymology / Q000235:genetics*
D007527:Isoenzymes; D005954:Glucosephosphate Dehydrogenase