title: The relationship between blood and cerebrospinal fluid prolactin in nonhuman primates.
abstract: We studied the relationship between plasma and cerebrospinal fluid (CSF) concentrations of prolactin (PRL) in repeated and simultaneous samples of blood and CSF from chair-restrained rhesus monkeys. Following administration of thyrotropin releasing hormone (TRH), each of 4 monkeys showed increased plasma and lumbar CSF PRL concentrations. Increases in CSF PRL concentrations were muted and delayed until 60 min after peak plasma concentrations were attained. In 3 other monkeys we compared PRL concentrations in simultaneous lateral ventricular and lumbar CSF samples. ALthough we found no difference in PRL concentrations under baseline conditions, a ventricular-lumbar PRL concentration gradient became apparent after TRH stimulation. These studies demonstrate that changes in plasma PRL concentrations are reflected in CSF concentrations. They suggest that a significant blood-CSF barrier exists for PRL and the PRL may enter the CSF selectively via the ventricles.
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D002552:Cerebral Ventricles; D008161:Lumbosacral Region; D008253:Macaca mulatta; D008297:Male; D011388:Prolactin / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000378:metabolism; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
chemical_list: D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin