[Interaction of synthetic peptides with the individual components of the blood coagulation system].
Spectrophotometry and viscosimetry were used to examine the interaction of taftcin and its decomposition products with individual components of the blood coagulation system. Peptides with free amino groups at the N-end were found to form complexes with heparin. The presence of free carboxylic groups at the C-end provided for their interaction with fibrinogen. In both the cases, the leading roles are played by electrostatic forces that determine the weakness of the effects seen. Taftcin has a negligible antipolymerization activity at the expense of the Pro-Arg sequence presence at the C-end.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D002417:Cattle; D004347:Drug Interactions; D005609:Free Radicals; D008297:Male; D008970:Molecular Weight; D010454:Peptide Termination Factors / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects
D005609:Free Radicals; D010454:Peptide Termination Factors; D010455:Peptides
Vzaimodeĭstvie sinteticheskikh peptidov s otdel'nymi komponentami sistemy svertyvaniia krovi.