Do OKT 3 monoclonal antibodies inhibit T-cell proliferation by blocking the receptor for TCGF?
OKT 3 monoclonal antibodies strongly inhibit the proliferation of T-cell growth factor (TCGF)-dependent continuously-growing T-lymphoblasts. The inhibition was shown to be dose-dependent reaching close to 70% in a concentration of 10 micrograms/ml. By using a purified radiolabelled TCGF preparation the inhibition was shown to take place at the level of growth factor binding. These results are consistent with OKT 3 monoclonal antibodies reacting with a membrane structure on or close to the TCGF receptor on activated human T-lymphocytes.
D000911:Antibodies, Monoclonal / Q000502:physiology*; D001667:Binding, Competitive; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D008213:Lymphocyte Activation; D011971:Receptors, Immunologic / Q000032:analysis*; D015375:Receptors, Interleukin-2; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D000911:Antibodies, Monoclonal; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2