[Production of monoclonal antibody anti-antigen 5 for Trypanosoma cruzi].
Monoclonal antibodies against Trypanosoma cruzi have been produced by fusion of Sp 2/0 myeloma cells and splenic lymphocytes from BALB/c Mice immunized with a T. cruzi antigenic fraction. Antigenic studies of these monoclonal antibodies have led to the identification of IgG 1 antibody against the component 5 specific for T. cruzi (cellular clone II 190/151). These monoclonal antibodies will give rise not only to new diagnostic and epidemiological perspectives but will also aid in achieving a better understanding of the biological role of this antigen.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis*; D002459:Cell Fusion; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D007158:Immunologic Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D011817:Rabbits; D014349:Trypanosoma cruzi / Q000276:immunology*
D000911:Antibodies, Monoclonal
Production d'un anticorps monoclonal anti-antigène 5 de Trypanosoma cruzi.