Chemical properties of Myxococcus xanthus antibiotic TA.
Antibiotic TA was purified and crystallized from culture fluids of Myxococcus xanthus TA. The antibiotic (C34H57O9N, M.W. 623.8) contained the following functional groups: ketone, lactone, secondary amide, methoxy-substituted diene (lambda max 239 nm), primary alcohol and three secondary alcohols, two of which were cis-vicinal. Mild alkaline hydrolysis opened the lactone with concomitant loss of antibiotic activity. Periodate oxidation also destroyed biological activity.
D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification*; D005285:Fermentation; D006851:Hydrochloric Acid; D006868:Hydrolysis; D006878:Hydroxides; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009231:Myxococcales / Q000378:metabolism*; D010084:Oxidation-Reduction; D011188:Potassium; D017680:Potassium Compounds; D013056:Spectrophotometry, Ultraviolet; D013464:Sulfuric Acids
D000900:Anti-Bacterial Agents; D006878:Hydroxides; D018942:Macrolides; D017680:Potassium Compounds; D013464:Sulfuric Acids; C035536:Myxococcus xanthus antibiotic TA; D006851:Hydrochloric Acid; D011188:Potassium; C029943:potassium hydroxide