[Rapid determination of valproic acid using instantaneous silylation].
We propose a technique for measuring valproic acid using gas phase chromatography with a OV1 column, classically used for steroid assays. The valproic acid is extracted directly from the plasma by either from a small test sample (200 microliters). The silylation is performed instantaneously at the level of the injector. The accuracy and precision of the method are excellent; there is no interference with other anti-convulsants. The technique is simple, very rapid and not expensive; it should find a wide application in routine practice.
D000081:Acetamides; D002849:Chromatography, Gas / Q000379:methods; D005463:Fluoroacetates; D006801:Humans; D008832:Microchemistry; D012825:Silicon; D014297:Trimethylsilyl Compounds; D014635:Valproic Acid / Q000097:blood*
D000081:Acetamides; D005463:Fluoroacetates; D014297:Trimethylsilyl Compounds; C030688:trifluoroacetamide; D014635:Valproic Acid; D012825:Silicon
Détermination rapide de l'acide valproïque par silylation instantanée.