Effect of carbon dioxide and pH on susceptibility of Bacteroides fragilis group to erythromycin.
We examined the effects of pH and incubation in a CO(2)-containing atmosphere on the activity of erythromycin against 81 strains of the Bacteroides fragilis group. A striking reduction in erythromycin activity was noted when the pH decreased below 7.0 and when the organisms were incubated with CO(2).
D001441:Bacteroides fragilis / Q000187:drug effects*; D002245:Carbon Dioxide / Q000494:pharmacology*; D004917:Erythromycin / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests
D002245:Carbon Dioxide; D004917:Erythromycin