The establishment and characterization of a cell line and mouse xenografts from a human malignant melanoma.
A permanent cell line has been established from a human intracranial secondary melanoma. During 3 years of continuous growth in vitro the cells have maintained their characteristic phenotypic properties including melanin production. The cultured cells are highly tumorigenic in the athymic mouse and the tumours produced are histologically identical to the human tumour of origin.
D000818:Animals; D001932:Brain Neoplasms / Q000556:secondary / Q000648:ultrastructure; D002455:Cell Division; D002460:Cell Line; D002467:Cell Nucleus / Q000187:drug effects; D002875:Chromosomes; D003571:Cytochalasin B / Q000494:pharmacology; D006801:Humans; D008543:Melanins / Q000096:biosynthesis; D008545:Melanoma / Q000556:secondary / Q000648:ultrastructure*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014183:Transplantation, Heterologous
D008543:Melanins; D003571:Cytochalasin B