Vascular effects of glucocorticosteroids, with special reference to budesonide.
The effect of glucocorticosteroids was tested on in vitro responses of tension developed by strips of umbilical blood vessels. 1. Hydrocortisone, methylprednisolone and dexametasone in concentrations of 10(-4)-10(-3) mainly inhibited spontaneous tone. Hydrocortisone and methylprednisolone induced a biphasic response with an initial small contraction followed by a more long lasting relaxation. 2. Budesonide, a novel powerful, non-halogenated steroid only induced a long lasting contraction. 3. The relaxation with hydrocortisone was of the same magnitude as after indomethacine, therefore, this response may be due to inhibition of prostaglandin-synthesis. 4. There was no leftward shift of the dose response curve to catecholamine stimulation but rather a slightly higher maximal response. There is no clear evidence of a uptake-2 blockade in our preparation.
D019819:Budesonide; D003907:Dexamethasone / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D005438:Fludrocortisone / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011282:Pregnenediones / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology; D014469:Umbilical Arteries / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects
D005938:Glucocorticoids; D011282:Pregnenediones; D012701:Serotonin; D019819:Budesonide; D003907:Dexamethasone; D005438:Fludrocortisone; D009638:Norepinephrine; D004837:Epinephrine