Serological and biochemical analyses of M components in patients with transitional cell carcinoma of the urinary bladder.
Serological and biochemical studies were performed on M components isolated from 3 patients with transitional cell carcinoma of the urinary bladder (TCC). All were IgG1(K) proteins. 2 of the 3 belonged to the VKI subgroup, and these 2 also possessed cross-reactive idiotypic determinants. These findings are consistent with the ideas that M components in patients with a given kind of cancer may have restricted heterogeneity, and that the synthesis of an M component and the manifestation of a solid tumor may be related events in some patients who exhibit both abnormalities.
D000595:Amino Acid Sequence; D000818:Animals; D001798:Blood Proteins / Q000032:analysis / Q000145:classification / Q000276:immunology*; D002295:Carcinoma, Transitional Cell / Q000276:immunology*; D003429:Cross Reactions; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000235:genetics; D007136:Immunoglobulins; D011817:Rabbits; D001749:Urinary Bladder Neoplasms / Q000276:immunology*
D001798:Blood Proteins; D007135:Immunoglobulin Variable Region; D007136:Immunoglobulins; C009823:M-proteins (Myeloma)