title: HLA antigens in renal cell carcinoma.
abstract: HLA antigen type was studied in 35 renal cell carcinoma patients who had bilateral disease, an early age of onset (less than age 45), or a family history of kidney cancer. Increased frequencies of the single-locus antigens HLA-DR8 (relative risk, 3.3) and HLA-Bw44 (relative risk, 2.1) and a deficit of HLA-DR1 (relative risk, 0.4) were found. Although based on small numbers, the relative excess was highest among persons phenotypically HLA-Bw44DR8. A higher frequency of the three-locus phenotype HLA-A3B7DR2 was also noted. The unusual HLA patterns were most pronounced among patients of German or Scandinavian origin, population groups reported to have an elevated risk of renal cancer.
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000276:immunology*; D000328:Adult; D000367:Age Factors; D005260:Female; D005858:Germany / Q000208:ethnology; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics / Q000276:immunology*; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D008910:Minnesota; D010641:Phenotype; D012306:Risk; D012537:Scandinavian and Nordic Countries / Q000208:ethnology
chemical_list: D006680:HLA Antigens