The effect of preoperative arteriography on vascular endothelium and replant survival in rabbit ears.
Although contrast media injected during arteriography is known to decrease microcirculatory blood flow and alter oxygen delivery capacity of the red blood cell, its effect on the vascular endothelium is unknown. This experiment was designed to determine if there were any alterations in arterial or venous endothelial anatomy by scanning electron microscopy and whether replant survival was decreased following arteriography. Our results suggest that when the injection pressure of arteriography is carefully controlled, the contrast media used in this experiment has no effect on vascular endothelium in rabbit ears examined 30 minutes and 24 hours after arteriography. Furthermore, the survival rate of replanted rabbit ears is not affected by arteriography 24 hours prior to replantation. We conclude that preoperative arteriography remains a valuable tool in the planning of free composite tissue transfer but, based on this study, cannot rule out mechanical complications of arteriography that may be deleterious to free tissue transfer.
D000792:Angiography / Q000009:adverse effects; D000818:Animals; D001158:Arteries / Q000187:drug effects* / Q000648:ultrastructure; D003287:Contrast Media / Q000494:pharmacology*; D004423:Ear / Q000098:blood supply; D004727:Endothelium / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D011300:Preoperative Care; D011817:Rabbits; D012092:Replantation; D014680:Veins / Q000187:drug effects* / Q000648:ultrastructure
D003287:Contrast Media