Rapid modulation by progesterone and tamoxifen of estradiol effects on nuclear histone acetylation in the uterus of the fetal guinea pig.
The effect of estradiol, progesterone, tamoxifen, estradiol + progesterone or estradiol + tamoxifen on the [3H]acetylation of histones in the fetal uterus of guinea pig was studied. The fetuses were injected subcutaneously 'in situ' with the hormones or tamoxifen + [3H]acetate alone. In 10 min, estradiol stimulated the acetylation of histone 10-12-times with respect to the control animals. Progesterone and tamoxifen blocked this effect. It is suggested that histone acetylation is an early step induced by estrogen action during intrauterine life and that progesterone and tamoxifen suppress this mechanism very effectively.
D000085:Acetates / Q000378:metabolism; D000107:Acetylation; D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005333:Fetus; D006168:Guinea Pigs; D006657:Histones / Q000378:metabolism*; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D013629:Tamoxifen / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D000085:Acetates; D006657:Histones; D013629:Tamoxifen; D011374:Progesterone; D004958:Estradiol