Histopathologic and ultrastructural analysis of congenital corneal staphyloma.
Although the visual prognosis for eyes with congenital corneal staphyloma has been considered hopeless, we successfully treated a 1-month-old girl with this condition. We performed two penetrating keratoplasties, operating on the left eye first and then, one week later, on the right eye. During each procedure, we totally resected the staphyloma and excised the iris which was adherent to the posterior surface of the cornea. We then sutured an 11-mm corneal button into place with 34 interrupted 10-0 nylon sutures. Light and transmission electron microscopy of the Descemet's membrane and endothelium. The left eye had two rejection episodes and underwent a second penetrating keratoplasty. The graft in this eye is now opaque. The child follows objects well with her right eye.
D003315:Cornea / Q000002:abnormalities* / Q000473:pathology / Q000601:surgery; D003319:Corneal Stroma / Q000648:ultrastructure; D006801:Humans; D007223:Infant; D008854:Microscopy, Electron