[Murine cloned cells related to basophil-mast cell granulocytes, spontaneously cytotoxic toward tumor cells].
Two independent cloned cell lines were derived following the in vitro expansion of spleen and bone-marrow cells suspensions from DBA/2 Mice in the presence of a conditioned medium containing interleukin II. They exhibit a spontaneous cytotoxicity towards two tumors of leukemic origin. The presence of cytoplasmic granules, their staining properties, the typing of surface markers and enzyme activities suggest that they belong to the basophil-mast cell lineage.
D000818:Animals; D001491:Basophils / Q000276:immunology; D002999:Clone Cells / Q000166:cytology; D003602:Cytotoxicity, Immunologic; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology*; D008297:Male; D008407:Mast Cells / Q000276:immunology; D051379:Mice; D008811:Mice, Inbred DBA; D009374:Neoplasms, Experimental / Q000276:immunology
Clones de cellules murines apparentées aux granulocytes basophiles-mastocytes, spontanément cytotoxiques vis-à-vis de cellules tumorales.