Sensorimotor impairments following localized kainic acid and 6-hydroxydopamine lesions of the neostriatum.
Rats received either control saline, 6-hydroxydopamine (6-OHDA) or kainic acid (KA) unilateral lesions of 5 different foci in the neostriatum. Both KA and 6-OHDA lesions in the mid-ventral focus resulted in a substantial and prolonged impairment in sensorimotor orientation to contralateral stimuli. At all other placements 6-OHDA induced a temporary mild impairment, and KA had no detectable biasing effects. The results suggest that the neostriatum is topographically heterogeneous in the mediation of this particular aspect of sensorimotor performance.
D000818:Animals; D001931:Brain Mapping; D003342:Corpus Striatum / Q000187:drug effects*; D004292:Dominance, Cerebral / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D006892:Hydroxydopamines / Q000633:toxicity*; D007608:Kainic Acid / Q000633:toxicity*; D008297:Male; D008465:Mechanoreceptors / Q000187:drug effects; D008856:Microscopy, Fluorescence; D009048:Motor Skills / Q000187:drug effects*; D009619:Nociceptors / Q000187:drug effects; D009949:Orientation / Q000187:drug effects*; D016627:Oxidopamine; D010465:Perception / Q000187:drug effects*; D011759:Pyrrolidines / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012903:Smell / Q000187:drug effects
D006892:Hydroxydopamines; D011759:Pyrrolidines; D016627:Oxidopamine; D007608:Kainic Acid; D004298:Dopamine