title: The effect of long-term cimetidine treatment on PRL and TSH response capacity to TRH in male patients with duodenal ulcer.
abstract: The effect of long-term cimetidine treatment for 6 months on basal and thyrotropin-releasing hormone (TRH)-stimulated prolactin (PRL) and thyroid-stimulating hormone (TSH) secretion was studied in eight male patients with duodenal ulcer. They received 1,000 mg cimetidine orally per day until ulcer healing and thereafter 400 mg daily for the remaining period. TRH perturbation tests were performed before and after the 6 months of treatment. A significant reduction in the pituitary TSH response capacity was found. No significant changes in basal and TRH-stimulated PRL, basal TSH, thyroxine and triiodothyronine were found. It is uncertain if the reduction in pituitary TSH response capacity has any clinical implications in euthyroid patients.
mesh_terms: D000328:Adult; D000368:Aged; D002927:Cimetidine / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000097:blood* / Q000188:drug therapy; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone; D013997:Time Factors
chemical_list: D006146:Guanidines; D013973:Thyrotropin-Releasing Hormone; D002927:Cimetidine; D011388:Prolactin; D013972:Thyrotropin