title: Tolerance and effects of high doses of ascorbic acid. Dosis facit venenum.
abstract: The few literature references suggesting adverse effects of high doses of ascorbic acid are outnumbered by a large number of clinical studies in which no adverse effects have been observed. Up to 5 g ascorbic acid daily may be administered safely even over a long term. Favourable effects of even higher doses in man may justify therapeutic trials in the range of 15 g daily which in our trials have proven safe during treatment of up to 2 years. Nevertheless, trials in the high dosage range mentioned should always be closely supervised by a physician, being aware that exceptional behaviour can occur at any time, as exception proves the rule.
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000506:poisoning; D001835:Body Weight; D002415:Cats; D002940:Circadian Rhythm; D004285:Dogs; D004361:Drug Tolerance; D006168:Guinea Pigs; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007928:Lethal Dose 50; D051379:Mice; D010070:Oxalates / Q000652:urine; D010084:Oxidation-Reduction; D011817:Rabbits; D051381:Rats
chemical_list: D010070:Oxalates; D001205:Ascorbic Acid