title: Impact of choice of anesthetic with vagotomy testing.
abstract: Incomplete vagotomy is the most important cause of recurrent ulcer disease. Despite this, intraoperative vagotomy testing has not gained widespread acceptance. We used a technique with Congo red, a nontoxic azine dye that turns black (pH, 3.0) intraoperatively. The vagolytic effects of various general anesthetics has been shown. We found that halothane, used as a general anesthetic, combined with pentagastrin administration as a vagally synergistic stimulant, produced the most reliable, safe, and reproducible result when using Congo red intraoperatively.
mesh_terms: D000768:Anesthesia, General; D000771:Anesthesia, Intravenous; D000818:Animals; D003224:Congo Red; D004285:Dogs; D004359:Drug Therapy, Combination; D004737:Enflurane / Q000008:administration & dosage; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects; D006221:Halothane / Q000008:administration & dosage*; D006863:Hydrogen-Ion Concentration; D007279:Injections, Subcutaneous; D007430:Intraoperative Care; D008614:Meperidine / Q000008:administration & dosage; D010418:Pentagastrin / Q000008:administration & dosage*; D010424:Pentobarbital / Q000008:administration & dosage; D011897:Random Allocation; D014628:Vagotomy
chemical_list: D003224:Congo Red; D004737:Enflurane; D008614:Meperidine; D010418:Pentagastrin; D010424:Pentobarbital; D006221:Halothane