Bidirectional transfer of electrical and carbachol kindling.
In two experiments rats were kindled by electrical stimulation or the infusion of carbachol, and subsequently rekindled by carbachol or electrical stimulation, respectively, in the amygdala. The rats that previously had been kindled using one agent kindled significantly faster and displayed significantly stronger seizures when rekindled using the other agent. These results are consistent with the idea that cholinoceptive neurons may normally participate in electrical kindling of the amygdala although such participation does not appear to be crucial.
D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D004292:Dominance, Cerebral / Q000187:drug effects*; D004558:Electric Stimulation; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D009115:Muridae; D011950:Receptors, Cholinergic / Q000187:drug effects
D011950:Receptors, Cholinergic; D002217:Carbachol