Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly.
A 44 amino acid peptide with growth hormone-releasing activity has been isolated from a human tumor of the pancreas that had caused acromegaly. The primary structure of the tumor-derived peptide is H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala- Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly -Ala-Arg-Ala-Arg-Leu-NH2. The synthetic replicate has full biological activity in vitro and in vivo specifically to stimulate the secretion of immunoreactive growth hormone. The tumor-derived peptide is identical in biological activity and similar in physiochemical properties to the still uncharacterized growth hormone-releasing factor present in extracts of hypothalamic tissues.
D000172:Acromegaly / Q000503:physiopathology*; D000595:Amino Acid Sequence; D001681:Biological Assay; D013007:Growth Hormone-Releasing Hormone / Q000138:chemical synthesis / Q000302:isolation & purification*; D006729:Hormones, Ectopic / Q000302:isolation & purification*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000737:chemistry*
D006729:Hormones, Ectopic; D013007:Growth Hormone-Releasing Hormone