An adaptive response to the cytotoxic effects of N-methyl-N-nitrosourea is apparently absent in normal human fibroblasts.
D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D045647:DNA Glycosylases; D004790:Enzyme Induction; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D008770:Methylnitrosourea / Q000494:pharmacology*; D008780:Methyltransferases / Q000378:metabolism*; D009699:N-Glycosyl Hydrolases / Q000378:metabolism; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D019853:O(6)-Methylguanine-DNA Methyltransferase
D009607:Nitrosourea Compounds; D008770:Methylnitrosourea; D008780:Methyltransferases; D019853:O(6)-Methylguanine-DNA Methyltransferase; D045647:DNA Glycosylases; D009699:N-Glycosyl Hydrolases