[Effect of thyroliberin on neurons of the sensorimotor cortex].
The effect of thyroliberin (thyrotropin-releasing hormone) on extracellularly recorded spontaneous activity of sensorimotor cortical neurons was studied in experiments on non-anesthetized rabbits. Thyroliberin injected intravenously in doses of 0.1-7.0 mg/kg had an excitatory effect on the cortical neurons. In contrast, thyroliberin had a depressant effect when applied microiontophoretically to individual neurons. It is concluded that the excitatory effect of thyroliberin on the cortex after systemic application is related to the facilitation of subcortical-cortical activating influences. Extracortical receptors of the excitatory type are likely to be responsible for the main central-stimulating properties of thyroliberin.
D000200:Action Potentials; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D007478:Iontophoresis; D009044:Motor Cortex / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D011817:Rabbits; D013003:Somatosensory Cortex / Q000502:physiology*; D013268:Stimulation, Chemical; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology / Q000502:physiology*
D013973:Thyrotropin-Releasing Hormone
Vliianie tiroliberina na neĭrony sensomotornoĭ kory golovnogo mozga.