Azathioprine-associated pulmonary dysfunction.
We present a case of azathioprine-associated alveolitis diagnosed by gallium-67 scanning and transbronchial biopsy. The patient denied respiratory symptoms, exhibited spiking fevers, and had normal chest roentgenograms. Allopurinol inhibition of azathioprine metabolism may have been a contributing factor.
D000328:Adult; D000493:Allopurinol / Q000494:pharmacology / Q000627:therapeutic use; D001379:Azathioprine / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D003424:Crohn Disease / Q000188:drug therapy; D006801:Humans; D007249:Inflammation / Q000139:chemically induced; D007669:Kidney Calculi / Q000517:prevention & control; D008171:Lung Diseases / Q000139:chemically induced*; D008297:Male; D011650:Pulmonary Alveoli / Q000187:drug effects*
D000493:Allopurinol; D001379:Azathioprine