Metabolism of 2,4',5-trichlorobiphenyl: tissue concentrations of methylsulphonyl-2,4',5-trichlorobiphenyl in germfree and conventional mice.
Whole-body autoradiography of 2,4',5-[14C]trichlorobiphenyl ([14C]triCB) indicated that, whereas there was accumulation of radioactivity in the tracheobronchial mucosa of conventional (C) mice 1-7 days after injection, no such effect was observed in germfree (GF) mice 1 day after injection. At days 4 and 7 there was a low, but significant, uptake by the tracheobronchial mucosa of the GF mice. Chemical analysis showed that the concentrations of 4-methylsulphonyl-triCB (4-MeSO2-triCB) in lung, kidney and liver 7 days after administration of triCB were 6.5, 14.7 and 3.7 times higher, respectively, in C than in GF mice. The results are interpreted as indicating the existence of a major metabolic route to triCB methyl sulphones involving the intestinal microflora, and a minor route, not requiring the flora.
D000818:Animals; D001345:Autoradiography; D005856:Germ-Free Life; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D011078:Polychlorinated Biphenyls / Q000378:metabolism*; D012137:Respiratory System / Q000378:metabolism; D013045:Species Specificity
C015550:2,4',5-trichlorobiphenyl; C035735:4-methylsulfonyl-2,4',5-trichlorobiphenyl; D011078:Polychlorinated Biphenyls