[Effect of imidazo(1,2-f)xanthine derivatives on cerebral cortical bioelectrical activity and evoked potentials].
Potassium salt of 8-bromotheophylline was made interact with alpha-bromoketones to obtain initial products (7-acylalkyl-8-bromotheophyllines) for the synthesis of the derivatives of 1H-imidazo(1,2-f)xanthine. 1-(beta-Oxyethyl)-2,3,6,8-tetramethylimidazo(1,2-f)xanthine and 1,2,6,8-tetramethylimidazo (1,2-f)xanthine were discovered to have a stimulant effect on the central nervous system, to increase the amplitude of evoked potentials of the visceral, auditory and cutaneous projection zones of the brain cortex, and to improve rhythm assimilation.
D000161:Acoustic Stimulation; D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects*; D004558:Electric Stimulation; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D013268:Stimulation, Chemical; D013997:Time Factors; D014970:Xanthines / Q000494:pharmacology*
D007093:Imidazoles; D014970:Xanthines
Vliianie nekotorykh proizvodnykh imidazo(1,2-f)ksantina na bioelektricheskuiu aktivnost' i vyzvannye potentsialy kory bol'shikh polushariĭ golovnogo mozga.