Endogenous induction of epoxide hydrolase, benzo(a)pyrene hydroxylase and glutathione-S-transferase in "responsive" C57Bl/6 mice and in "nonresponsive" DBA/2 mice during pregnancy.
Gestational changes in activity for three enzymes associated with different hepatic and pulmonary drug metabolizing systems were investigated in C57Bl/6 and DBA/2 mice: benzo(a)pyrene hydroxylase, epoxide hydrolase and glutathione-S-transferase. The gestational profiles of hepatic and pulmonary benzo(a)pyrene hydrolase, and epoxide hydrolase were similar in both strains. In addition, we demonstrated higher endogenous stimulation of the three studied enzymic activities in C57Bl/6 mice. During the second moiety of pregnancy, temporal variations were observed: a peak of activity occurred between days 17 and 18 for lung and liver benzo(a)pyrene hydroxylase and at day 20 for epoxide hydrolase in both strains. Hepatic glutathione-S-transferase variations were similar in both strains. However, pulmonary glutathione-S-transferase increased gradually throughout pregnancy in C57Bl/6 mice, while a peak of glutathione-S-transferase activity occurred on day 18 of gestation in DBA/2 mice.
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis*; D001579:Benzopyrene Hydroxylase / Q000096:biosynthesis*; D004790:Enzyme Induction; D004851:Epoxide Hydrolases / Q000096:biosynthesis*; D005260:Female; D005982:Glutathione Transferase / Q000096:biosynthesis*; D008099:Liver / Q000201:enzymology; D008168:Lung / Q000201:enzymology; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D011247:Pregnancy; D011270:Pregnancy, Animal
D001579:Benzopyrene Hydroxylase; D001189:Aryl Hydrocarbon Hydroxylases; D005982:Glutathione Transferase; D004851:Epoxide Hydrolases