The myxovirescins, a family of antibiotics from Myxococcus virescens (Myxobacterales).
The myxobacterium, Myxococcus virescens strain Mx v48 produced a family of at least 12 closely related antibiotics, the myxovirescins. At a concentration of 1 to 5 micrograms/ml, the main component, myxovirescin A, was bactericidal for many Gram-negative bacteria, in particular enterobacteria, and at 20 to 50 micrograms/ml it also inhibited some pseudomonads and Gram-positive bacteria. The antibiotics seem to interfere with cell wall synthesis. The molecular formula of myxovirescin A was C35H61NO8. It is a new antibiotic.
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D007783:Lactones / Q000494:pharmacology; D009231:Myxococcales / Q000032:analysis*
D000900:Anti-Bacterial Agents; D007783:Lactones; C036969:myxovirescin A