The effect of E-N-L-trimethyllysine (TML) on the humoral and cellular immune response.
E-N-L-Trimethyllysine glutamate (TML) influences the humoral and cellular immune response of mice. Chronic pre- and post-treatment (100 mg/kg/day, 5 times) transitionally increased the anti-SRBC haemagglutinin titre of female CBA mice. After 400 r whole body irradiation, TML treatment accelerated the normalization of the haemagglutinin level. TML treatment prolonged the life-span of BDF1 hybrid mice that had first been immunized and then inoculated with L1210 cells. TML diminished the delayed type hypersensitivity reaction in vivo of irradiated and non-irradiated CBA female mice and dose-dependent decreased the spontaneous (SLMC) and antibody-dependent (ADCC) cytotoxicity of healthy human lymphocytes, in vitro. As a low molecular weight immunomodulant, TML may also be considered as a therapeutic tool.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects*; D007939:Leukemia L1210 / Q000276:immunology; D007978:Levamisole / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects; D008239:Lysine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051379:Mice; D013997:Time Factors; D014916:Whole-Body Irradiation
D007978:Levamisole; C003712:trimethyllysine; D008239:Lysine