Association between the MB system and asthma in the Japanese.
Twenty-three unrelated Japanese patients with asthma who showed a high total serum IgE level, a strong skin test response to Dermatophagoides farinae, and a high score on a radioallergosorbent test (RAST) using Dermatophagoides farinae were typed for HLA-A locus, -B locus, and -D region antigens. No significant difference in the frequencies of HLA-A, -B, and -DR antigens were observed between the asthma patients and the healthy controls. A significant difference in the frequency of MB3', however, was found between the asthma patients and the healthy controls (corrected p = 0.04, relative risk = 18.5).
D001249:Asthma / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000276:immunology; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007564:Japan; D011852:Radioallergosorbent Test
D006680:HLA Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D007073:Immunoglobulin E