title: Treatment of juvenile arthritis.
abstract: Aspirin remains the cornerstone of treatment for juvenile arthritis, although tolmetin may be more effective in controlling the fever of systemic-onset disease. Tolmetin and naproxen appear to be more effective in HLA-B27 positive males with pauciarticular disease. When the nonsteroidal anti-inflammatory drugs fail, gold, penicillamine and, occasionally, immunosuppressive agents may be used in the polyarticular forms. Prosthetic joint replacement may be beneficial for patients with extensive disease. The emotional and sexual problems of children with chronic disease require recognition and help.
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000628:therapy*; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D005260:Female; D006046:Gold / Q000627:therapeutic use; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D007595:Joint Prosthesis; D008297:Male; D010396:Penicillamine / Q000627:therapeutic use; D011613:Psychotherapy; D012202:Reye Syndrome / Q000139:chemically induced; D013585:Synovitis / Q000601:surgery; D013608:Tablets, Enteric-Coated
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D013608:Tablets, Enteric-Coated; D006886:Hydroxychloroquine; D006046:Gold; D010396:Penicillamine; D001241:Aspirin