[Prevention of postresuscitation heart failure by using ionol].
Clinical death of animals caused by acute hemorrhage and subsequent resuscitation induce lipid peroxidation in the myocardium accompanied by depression of contractile function and massive efflux of enzymes into the coronary perfusate. Preliminary administration of the antioxidant ionol (100 mg/kg) for 3 days prior to clinical death resulted in a twofold decrease of the lethality during the post-resuscitation period, substantially diminishing activation of lipid peroxidation and efflux of enzymes to the coronary perfusate. Disturbances of myocardial contractility were thus prevented to a considerable degree.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006333:Heart Failure / Q000503:physiopathology / Q000517:prevention & control*; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D012151:Resuscitation / Q000009:adverse effects*
D000975:Antioxidants; D008054:Lipid Peroxides; D002084:Butylated Hydroxytoluene
Preduprezhdenie postreanimatsionnoĭ nedostatochnosti serdtsa s pomoshch'iu ionola.