[Effect of xidiphone and vitamin E on lipid metabolism patterns in dyslipidemia induced by cholesterol loading].
Spectrum of lipids, their transport forms in blood serum and phospholipid composition in erythrocyte membranes were studied under conditions of dislipidemia induced by cholesterol loading after treatment with a mixture containing diphosphonate (xidiphone) and vitamin E as well as with the only vitamin E. Lypolytic reactions of metabolims were activated during simultaneous treatment with xidiphone and vitamin E: content of NEFA and triglycerides as well as of lipoprotein atherogenous fractions was decreased in blood, at the same time, decrease of lysophosphatidylcholine and phosphatidylcholine and increase of phosphatidylethanolamine were found in erythrocyte membranes. The data obtained are in agreement with the hypothesist hat membrane-stabilizing drugs improve cell metabolism in pathological conditions related to deterioration of cytomembrane structure components.
D000818:Animals; D002784:Cholesterol / Q000494:pharmacology*; D004164:Diphosphonates / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000378:metabolism; D008064:Lipidoses / Q000378:metabolism*; D008055:Lipids / Q000097:blood*; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D008563:Membrane Lipids / Q000097:blood; D010743:Phospholipids / Q000097:blood*; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology*
D004164:Diphosphonates; D008055:Lipids; D008563:Membrane Lipids; D010743:Phospholipids; D014810:Vitamin E; D002784:Cholesterol
Deĭstvie ksidifona i vitamina E na pokazateli lipidnogo obmena pri dislipidemii, indutsirovannoĭ kholesterinovoĭ nagruzkoĭ.