The role of the myocardial water content in heart function.
In previous experiments a considerable interstitial oedema developed after myocardial infarction followed by the infusion of 6 mmol/kg/min norepinephrine lasting for 10 min in the 2nd and 48th hours as well as after a 60 min period of ventricular fibrillation during cardiopulmonary bypass. On the other hand myocardial dehydration was induced by hyperosmolality of 320-470 mOsm/l caused by mannitol or glucose after pancreatectomy. A close bilinear correlation was found between the myocardial water content and the increase of ventricular diastolic stiffness. It was further established that the increase of ventricular stiffness is followed by a decrease of the cardiac output index measured during left ventricular afterload. The cardiac output index was lower after myocardial infarction and pancreatectomy than during cardiopulmonary bypass or mannitol-treatment. Of clinical importance is the fact that ventricular performance decreases when myocardial water content exceeds or does not reach the value of 760-790 g water per 1000 g myocardium.
D000818:Animals; D001834:Body Water / Q000378:metabolism*; D002302:Cardiac Output; D009202:Cardiomyopathies / Q000503:physiopathology; D002315:Cardiopulmonary Bypass; D003681:Dehydration / Q000503:physiopathology; D003971:Diastole; D004285:Dogs; D004487:Edema / Q000503:physiopathology*; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology; D006728:Hormones / Q000494:pharmacology; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000494:pharmacology; D009994:Osmolar Concentration; D010180:Pancreatectomy
D006728:Hormones; D008353:Mannitol; D009638:Norepinephrine