T-antigen does not induce cell mediated immunity in patients with breast cancer.
A total of 80 subjects with benign and malignant breast disease and healthy controls were studied for reactivity to T-antigen, MN-antigens and phytohemagglutinin (PHA) using the lymphocyte blastogenesis assay. No differences were detected between controls and patients with benign or malignant breast disease in reactivity to T- and MN-antigens. Moreover, there was no differential response to T- and MN-antigens among patients with breast cancer. PHA reactivity, although similar between groups as a whole, was diminished in patients with advanced carcinoma. These findings indicate that T-antigen fails to induce cell mediated immunity in patients with breast cancer.
D000328:Adult; D000951:Antigens, Neoplasm / Q000276:immunology*; D001943:Breast Neoplasms / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008951:MNSs Blood-Group System / Q000276:immunology; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000494:pharmacology
D000951:Antigens, Neoplasm; D008951:MNSs Blood-Group System; D010835:Phytohemagglutinins