Elimination of glyceryl trinitrate: effects of sex, age, species and route of administration.
1 Orally administered glyceryl trinitrate to rats undergoes extensive first pass metabolism leading to low bioavailability. 2 Sex differences in the plasma elimination of glyceryl trinitrate were seen in the rat, the female exhibiting the longer plasma half-life. No sex differences in this respect were detected in the rabbit. 3 The plasma half-life of glyceryl trinitrate was longer and the volume of distribution larger, in older animals. 4 The plasma elimination of glyceryl trinitrate was different in various animal species. There was a good correlation between plasma half-life and animal bodyweight.
D000375:Aging; D000818:Animals; D006224:Cricetinae; D005260:Female; D005289:Ferrets; D006168:Guinea Pigs; D006207:Half-Life; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D013045:Species Specificity
D005996:Nitroglycerin