Effect of prolonged administration of gastrin on experimental carcinogenesis in rat colon induced by intrarectal instillation of N-methyl-N'-nitro-N-nitrosoguanidine.
The effect of tetragastrin on the incidence and histology of colonic tumors induced by intrarectal instillation of N-methyl-N'-nitro-N-nitrosoguanidine was investigated in Wistar rats. Prolonged administration of tetragastrin in depot form during and after treatment with N-methyl-N'-nitro-N-nitrosoguanidine resulted in a significant reduction in the incidence of colonic tumors in Experimental Week 35. Histological examinations showed that, unlike the well-differentiated adenocarcinomas with a typical glandular pattern in control groups, the adenocarcinomas that developed in rats treated with tetragastrin had high mucin-producing activity.
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000517:prevention & control; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced* / Q000517:prevention & control; D005755:Gastrins / Q000008:administration & dosage*; D007279:Injections, Subcutaneous; D008297:Male; D008769:Methylnitronitrosoguanidine; D009374:Neoplasms, Experimental / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D012509:Sarcoma / Q000139:chemically induced; D013758:Tetragastrin / Q000008:administration & dosage*
D005755:Gastrins; D013758:Tetragastrin; D008769:Methylnitronitrosoguanidine