Animal models of strabismic amblyopia: comparative behavioral studies.
Visual acuity and visuo-motor behavior were assessed in various models of experimental amblyopia in cats (n = 15). Three models of strabismic amblyopia were studied: surgical esotropia by sectioning one lateral rectus muscle; comitant optical strabismus by rearing cats with goggles which placed a stationary wedge prism before one eye; and incomitant optical strabismus by rearing cats with goggles which placed a rotatable wedge prism before one eye. These cats were compared with normal and monocularly deprived cats. Clear amblyopic deficits were found in monocularly deprived, esotropic and rotating prism cats. The amblyopic deficits were graded among these preparations, being most severe in monocularly deprived cats and least severe in esotropic cats. The degree of behavioral amblyopia in these preparations was correlated with the extent of physiological abnormalities in visual cortex and the lateral geniculate nucleus. Fixed optical strabismus did not result in behavioral deficits and does not appear to be a good model of strabismic amblyopia. Variable optical strabismus, on the other hand, produced clear deficits in one eye, both behaviorally and physiologically, without impaired ocular motility.
D000550:Amblyopia / Q000503:physiopathology*; D000818:Animals; D002415:Cats; D003624:Darkness / Q000009:adverse effects; D004195:Disease Models, Animal; D004948:Esotropia / Q000503:physiopathology; D005133:Eye Movements; D009801:Oculomotor Muscles / Q000601:surgery; D012683:Sensory Deprivation / Q000502:physiology; D013285:Strabismus / Q000503:physiopathology*; D014792:Visual Acuity