title: Radial maze performance in three strains of mice: role of the fimbria/fornix.
abstract: Three strains of mice were tested on an 8-arm radial maze, an index of hippocampus-dependent spatial memory. Levels of performance differed between strains with C57Br/cj greater than Balb/cj greater than C57Bl/6j. Lesions of the fimbria/fornix disrupted performance in the C57Br and Balb strains: the C57Bl mice never performed better than chance before or after surgery. Choline acetyltransferase activity in hippocampus was not correlated with radial maze performance. These findings suggest a possible genetic contribution towards radial maze behavior.
mesh_terms: D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D004193:Discrimination Learning / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D007031:Hypothalamus / Q000502:physiology*; D007034:Hypothalamus, Posterior / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D009949:Orientation / Q000502:physiology; D013045:Species Specificity
chemical_list: D002795:Choline O-Acetyltransferase