The inhibition of urease and proteases by sodium saccharin.
Sodium saccharin, at concentrations similar to those in the urine of rats fed 1-5% sodium saccharin in their diet, markedly inhibited urease, and 3 proteases in vitro and sodium ion did not appear to play a role in enzyme inhibition. These observations suggest that enzyme inhibition of any of a large number of enzymes may play a role in the tumorigenesis of the urinary bladder by saccharin.
D002273:Carcinogens; D010206:Papain / Q000037:antagonists & inhibitors; D010434:Pepsin A / Q000037:antagonists & inhibitors; D011480:Protease Inhibitors; D012439:Saccharin; D013820:Thermolysin / Q000037:antagonists & inhibitors; D014510:Urease / Q000037:antagonists & inhibitors*
D002273:Carcinogens; D011480:Protease Inhibitors; D010206:Papain; D010434:Pepsin A; D013820:Thermolysin; D014510:Urease; D012439:Saccharin