[Diabetes mellitus and the biosynthesis of porphyrins].
The blood and urine porphyrin content and porphyrin biosynthesis in the red blood cells after delta-amino levulinic acid (ALA) incubation, porphobilinogen and non-consumed ALA levels, porphobilinogen-synthetase activity were studied in 86 patients divided into 3 groups depending on diabetes severity. Porphyrin separation was investigated by means of thin-layer chromatography. It was found that porphyrin biosynthesis decreases in all diabetics at the early periods of the disease, not depending on its severity. Porphyrin biosynthesis is lowered during a phase of chronic renal insufficiency in patients with diabetic nephropathy. Porphyrin metabolic disorder is caused by hepatic dysfunction and diabetic nephropathy development.
D000328:Adult; D000368:Aged; D003920:Diabetes Mellitus / Q000378:metabolism* / Q000473:pathology; D003928:Diabetic Nephropathies / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000378:metabolism; D000623:Porphobilinogen Synthase / Q000378:metabolism; D011166:Porphyrins / Q000096:biosynthesis*; D011704:Pyelonephritis / Q000378:metabolism / Q000473:pathology
D011166:Porphyrins; D000623:Porphobilinogen Synthase
Sakharnyĭ diabet i biosintez porfirinov.