Effect of serum zinc level on amount of collagen-hydroxyproline in the healing gut during total parenteral nutrition: an experimental study.
Changes of serum zinc level in dogs receiving either a zinc-free solution or a zinc-supplement solution during total parenteral nutrition (TPN) and the influence of variety of serum-zinc level on serum albumin and collagen-hydroxyproline (C-Hyp) in the incised intestine were investigated. The serum zinc level of zinc-free dogs that was 126.0 +/- 34.3 micrograms per deciliter at the initiation of TPN decreased significantly to 80.0 +/- 15.0 micrograms per deciliter during the one week of TPN, whereas that of zinc-supplement dogs did not decrease during the same period of TPN. Lowering of the serum albumin value was more evident in zinc-free dogs than in zinc-supplement dogs. The amount of C-Hyp in the incised area of the intestine of zinc-free dogs was 2.63 +/- 0.66 micrograms per milligram and that of zinc-supplement dogs was 4.26 +/- 1.04 micrograms per milligram and this difference was significant. It was found that serum zinc level during TPN sharply reflects a supplement of zinc, and C-Hyp in the incised gut and serum albumin of zinc-free dogs are lower than those of zinc-supplement dogs.
D000818:Animals; D003094:Collagen / Q000378:metabolism*; D004285:Dogs; D006909:Hydroxyproline / Q000378:metabolism*; D007082:Ileum / Q000502:physiology*; D010288:Parenteral Nutrition; D010289:Parenteral Nutrition, Total; D012709:Serum Albumin / Q000378:metabolism; D014945:Wound Healing; D015032:Zinc / Q000097:blood* / Q000627:therapeutic use
D012709:Serum Albumin; D003094:Collagen; D015032:Zinc; D006909:Hydroxyproline