Methoxyindoles and photoreceptor metabolism: activation of rod shedding.
Using an in vitro eye-cup preparation, we have evaluated a potential relationship between methoxyindole metabolism and photoreceptor disk shedding. Melatonin, 6-chloromelatonin, and 5-methoxytryptophol all activate rod disk shedding in culture. The effect is compound specific since serotonin and N-acetylserotonin are without effect, and it is similar to shedding in vivo because it is evoked by light and is quantitatively comparable to a normal intact animal response. The results suggest the involvement of 5-methoxyindoles in the control of rhythmic photoreceptor metabolism.
D000818:Animals; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D008550:Melatonin / Q000031:analogs & derivatives / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects; D010786:Photoreceptor Cells / Q000378:metabolism*; D014982:Xenopus laevis
D007211:Indoles; C024100:6-chloromelatonin; C002465:methoxytryptophol; D008550:Melatonin