Effect of estrogen treatment on calcium uptake by the rat uterine smooth muscle.
The effect of estrogenization on cellular 45Ca uptake by the isolated uterine strips was studied. Whereas estrogenization 1 h before sacrifice of ovariectomized rats caused no significant change in Ca uptake by the isolated uteri, exposure to estrogen 24 h before sacrifice resulted in a significant increase in uptake. Following continuous exposure for 72 h to estrogen, the uptake of Ca was increasd by more than two-fold. Increased Ca uptake following estrogenization may largely account for the increased contractile responses of the uterine smooth muscle particularly those induced by potassium depolarization.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002369:Castration; D004717:Endometrium / Q000187:drug effects / Q000378:metabolism*; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004967:Estrogens; D002118:Calcium