title: Focal increases of white matter glucose utilization produced by electrical stimulation of rat motor cortex.
abstract: The right motor cortex was electrically stimulated in adult, awake rats for 45 min. Local cerebral glucose utilization (LCGU) was measured in white matter pathways with the (14C)-2-deoxyglucose method. Stimulation increased LCGU in focal regions of the right internal capsule to 51.3 mumol/100 g/min, compared to 39.8 on the control left side. Stimulation also increased LCGU in the right, medial pontine pyramidal tract to 36.2 mumol/100 g/min, compared with 27.3 on the control left side. The data demonstrate that electrical stimulation of motor cortex neurons increases LCGU 30 to 40% in the efferent myelinated axons of those neurons.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004558:Electric Stimulation; D005260:Female; D005947:Glucose / Q000378:metabolism*; D009044:Motor Cortex / Q000378:metabolism*; D051381:Rats / Q000502:physiology*; D011919:Rats, Inbred Strains
chemical_list: D005947:Glucose