On the role of the septal area in the development of DOCA-salt hypertension in the rat.
The extensive destruction of forebrain noradrenergic nerve terminals by the intraventricular injection of 250 micrograms of 6-hydroxydopamine prevents the subsequent development of DOCA-salt experimental hypertension in rats while the lesser destruction of noradrenergic nerve terminals produced by 90 micrograms of 6-hydroxydopa does not. The greatest difference in brain part noradrenaline levels between these two neurotoxins was in the septal area where noradrenaline was less than 15% of controls after 6-hydroxydopamine but was the same as controls after 6-hydroxydopa. The non-specific destruction of the lateral septal area by radiofrequency lesions prevented the subsequent development of DOCA-salt hypertension. The relatively selective destruction of catecholamine nerve terminals in the lateral septal area by the injection of 1 microgram 6-hydroxydopamine in 1 microliter vehicle also prevented the development of DOCA-salt hypertension. These data suggest that the lateral septal area may be the location of the forebrain catecholaminergic neural activity that is necessary for the development of DOCA-salt experimental hypertension in rats.
D000818:Animals; D001921:Brain / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism*; D003900:Desoxycorticosterone; D004298:Dopamine / Q000378:metabolism; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012688:Septum Pellucidum / Q000378:metabolism / Q000503:physiopathology*; D012701:Serotonin / Q000378:metabolism; D012964:Sodium / Q000097:blood
D002395:Catecholamines; D012701:Serotonin; D003900:Desoxycorticosterone; D012964:Sodium; D004298:Dopamine; D009638:Norepinephrine