title: [Tolerability of pirprofen during prolonged treatment].
abstract: During a non-comparative multicentric study, 70 patients suffering from various rheumatological diseases were treated by pirprofen for an average duration of 32 weeks (from 1 to 121 weeks). The daily dose varied from 400 to 1200 mg. Efficacy was judged good or excellent in 53 of the 70 patients (75%). Side effects, especially digestive, were noted in 27 patients (38%). They only caused discontinuation of treatment in 9 patients (13%). Amongst the 38 side effects, 26 occurred during the first 8 weeks of treatment. Despite the long duration of the treatment, the overall tolerance of pirprofen was good or acceptable in 87,5% of patients. The very high level of compliance in this long-term treatment attests to the good tolerance of pirprofen.
mesh_terms: D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D010666:Phenylpropionates / Q000009:adverse effects* / Q000627:therapeutic use; D012216:Rheumatic Diseases / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D010666:Phenylpropionates; C008924:pirprofen
vernacular_title: Etude de la tolérance du pirprofène lors de traitements prolongés.