[Molecular heterogeneity of the collagen from the skin of white rats in the early postnatal period].
Content and biosynthesis of collagens of I and III types were studied in skin of 5 and 50 days old rats. The ratio of collagens of the I and III types was equal to 17.84 in the skin of 5 days old rats and to -- 13.42 in the tissue of 50 days old rats. The collagen biosynthesis was studied using 14C-glycine incorporation. The ratio of 14C-collagens of the I and III types was equal to 47.53 and 50.03 in the skin of 5- and 50 days old animals, respectively. The data obtained showed occurrence of collagen III biosynthesis of comparatively low rate in rat skin within the postnatal period. The phenotypic modulation of biosynthesis of these collagen types exhibited the step-like pattern in the change from embryogenesis to postnatal development of rats.
D000375:Aging; D000818:Animals; D002850:Chromatography, Gel / Q000379:methods; D002852:Chromatography, Ion Exchange / Q000379:methods; D003094:Collagen / Q000032:analysis / Q000378:metabolism*; D006128:Growth; D010434:Pepsin A / Q000494:pharmacology; D051381:Rats; D012867:Skin / Q000378:metabolism*; D012995:Solubility
D003094:Collagen; D010434:Pepsin A
Molekuliarnaia geterogennost' kollagena kozhi belykh krys v rannem postnatal'nom periode.