[Influence of macrophage culture supernatants on erythroblastic islets in rat erythropoiesis].
The isolation of central macrophages from erythroblastic islands (EI) permitted analysis of the role of EI macrophage factors in erythropoiesis. EI macrophage supernatant and peritoneal macrophage supernatant both had a similar effect on erythropoiesis. They exerted an erythropoietin-like effect. We observed changes in the number of erythroblasts per island; their distribution within each island during the maturation process was described. The role of the central macrophage in EI was discussed. We suggested a direct transfer of an erythropoietin-like activity to the erythroblasts which increases the efficacy of stimulation.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D001854:Bone Marrow Cells; D002452:Cell Count; D002478:Cells, Cultured; D004900:Erythroblasts / Q000166:cytology*; D004912:Erythrocytes / Q000166:cytology*; D004920:Erythropoiesis; D004921:Erythropoietin / Q000008:administration & dosage / Q000502:physiology; D005260:Female; D008264:Macrophages / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical
D004921:Erythropoietin
Influence des surnageants de culture de macrophages provenant des îlots érythroblastiques sur l'érythropoïèse du rat.