Amines induce increased thromboplastin activity in human monocytes.
A variety of amines induced a dose-dependent and time-dependent increase in thromboplastin activity of cultured human monocytes. The increase required protein synthesis, and reached a peak after about 18 h. Some inhibitory effects were noted at low concentrations of NH4Cl. It is suggested that the amines act by raising the pH of acidic intracellular compartments.
D000588:Amines / Q000494:pharmacology*; D000643:Ammonium Chloride / Q000494:pharmacology; D000818:Animals; D001798:Blood Proteins / Q000096:biosynthesis; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D009000:Monocytes / Q000378:metabolism*; D013925:Thromboplastin / Q000378:metabolism*
D000588:Amines; D001798:Blood Proteins; D000643:Ammonium Chloride; D013925:Thromboplastin