Monoclonal gammopathy with neurological signs and symptoms. A clinical, neurophysiological and muscle biopsy study.
Clinical, neurophysiological and muscle biopsy findings in ten patients with monoclonal gammopathy are reported. Three patients had polyneuropathy, one had hemiparkinsonism, one migraine and radicular symptoms and one paresthesiae and radicular symptoms. Amyloidosis was not found in muscle biopsy specimens. All but one patient with neurological findings also had positive immunofluorescence staining for tissue-bound immunoglobulins in muscle biopsy specimens. The tissue-bound immunoglobulins usually belonged to the same class as the M-component. None of the biopsies of patients without neurological findings were positive.
D000368:Aged; D000911:Antibodies, Monoclonal / Q000032:analysis*; D001706:Biopsy; D004576:Electromyography; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D007075:Immunoglobulin M / Q000378:metabolism; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism; D007146:Immunoglobulin lambda-Chains / Q000378:metabolism; D008297:Male; D008475:Median Nerve / Q000503:physiopathology; D008875:Middle Aged; D009132:Muscles / Q000276:immunology / Q000473:pathology*; D009220:Myositis / Q000276:immunology; D009422:Nervous System Diseases / Q000276:immunology*; D009431:Neural Conduction; D009468:Neuromuscular Diseases / Q000276:immunology; D011115:Polyneuropathies / Q000276:immunology
D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains