[Enhancement by sodium butyrate of the cytotoxic effect of methotrexate on leukemic cells].
Sodium butyrate at a concentration of 1 x 10(-3) M or lower seems to decrease the rate of cellular proliferation through the cell cycle in G 1 phase. This effect makes them more sensitive to the cytotoxic action of moderate doses of methotrexate.
D000818:Animals; D002087:Butyrates / Q000494:pharmacology*; D020148:Butyric Acid; D002455:Cell Division / Q000187:drug effects; D004357:Drug Synergism; D007940:Leukemia L5178 / Q000473:pathology*; D007942:Leukemia, Experimental / Q000473:pathology*; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice
D002087:Butyrates; D020148:Butyric Acid; D008727:Methotrexate
Augmentation de l'effet cyto-toxique du methotrexate sur des cellules leucémiques par le butyrate de sodium.