Adenosine deaminase in renal ontogeny and compensatory hypertrophy in the rat.
Recent studies have indicated a possible link between cell proliferation and adenosine deaminase (ADase); the characteristics and specific activity of ADase in the kidney of neonatal rats and unilaterally nephrectomized rats were therefore determined. The enzyme was found to have a molecular weight of 35,000. Two variants with electrophoretic points at pH 4 x 53 (ADase I) and 4 x 63 (ADase II) were resolved by analytical isoelectric focusing. Enzyme activity was high in newborn rats (250 milliunits/mg protein) but declined to about 150 milliunits/mg protein from 20 days old to maturity. Enzyme activity and its biochemical characteristics were not altered in compensatory renal hypertrophy (CRH).
D000243:Adenosine Deaminase / Q000378:metabolism*; D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D005260:Female; D006984:Hypertrophy; D007668:Kidney / Q000201:enzymology / Q000254:growth & development* / Q000473:pathology; D008297:Male; D008970:Molecular Weight; D009392:Nephrectomy; D009700:Nucleoside Deaminases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase