title: Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
abstract: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability. Similar activity is also secreted by these tumor cells and a variety of other tumor cell lines in vitro. The permeability-increasing activity purified from either the culture medium or ascites fluid of one tumor, the guinea pig line 10 hepatocarcinoma, is a 34,000- to 42,000-dalton protein distinct from other known permeability factors.
mesh_terms: D000818:Animals; D001201:Ascites / Q000503:physiopathology; D001202:Ascitic Fluid / Q000502:physiology; D002199:Capillary Permeability; D006224:Cricetinae; D006168:Guinea Pigs; D051379:Mice; D009374:Neoplasms, Experimental / Q000503:physiopathology*