title: Influence of sleep state on the response to hypercapnia in fetal lambs.
abstract: The effect of sleep state on the respiratory response to hypercapnia was studied in 14 chronic fetal sheep, 125-140 days gestation. Fetal PaCO2 was raised by 11 to 34 Torr by gradually increasing the maternal FICO2 to 0.09. Fetal sleep state was monitored. Fetal breathing (FB) was analysed in terms of frequency (f), tracheal pressure (TP) and ventilation equivalent (VEq) = sigma TP /min. In 16 out of 17 experiments on apneic fetuses in NREM sleep, the fetuses switched to REM sleep and in 14 instances began to breathe within 2 1/2 min thereafter. The PaCO2 at which apneic fetuses started breathing was 54.8 +/- 8.4 Torr (mean +/- SD). In 4 out of 10 trials on breathing fetuses in REM sleep the fetuses switched to NREM sleep and stopped breathing before removal of the CO2 stimulus. During REM sleep hypercapnia stimulated FB by an increase in TP and by a reduction in the number and duration of apneic pauses. It is concluded that in the fetal lamb CO2 stimulates breathing only during REM sleep and that this stimulus is superimposed on the basic mechanism that stimulated spontaneous FB during this sleep state.
mesh_terms: D000818:Animals; D001158:Arteries; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D006863:Hydrogen-Ion Concentration; D006935:Hypercapnia / Q000196:embryology*; D010100:Oxygen / Q000097:blood; D011247:Pregnancy; D012119:Respiration; D012756:Sheep / Q000196:embryology*; D012894:Sleep Stages / Q000502:physiology*
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen