[Calcium and lipid peroxidation in the heart mitochondrial and microsomal membranes].
Effect of the lipid peroxidation (LP) on the Ca2+-transport and the effect of different Ca2+-concentrations on the LP activation were studied in microsomes and mitochondria of the heart. A slight accumulation of LP-products in the microsomal fraction results in a complete inhibition of the membrane calcium-transport activity. Preliminary administration of antioxidants (4-methyl 2,6-ditretbutylphenol and alpha-tocopherol) prevents both the accumulation of LP-products and damage of the Ca2+-transport system. Calcium at 10(-6) M to 5 X 10(-5) M concentrations stimulates LP and while being increased to 2 X 10(-3) M it inhibits LP. The data obtained evidence an interrelation between alterations of the Ca2+-concentrations and LP activation in cardiomyocytes.
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D002413:Cations, Divalent / Q000378:metabolism; D007425:Intracellular Membranes / Q000378:metabolism*; D007700:Kinetics; D008054:Lipid Peroxides / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism; D008861:Microsomes / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats
D002413:Cations, Divalent; D008054:Lipid Peroxides; D008315:Malondialdehyde; D002118:Calcium
Kal'tsiĭ i perekisnoe okislenie lipidov v membranakh mitokhondriĭ i mikrosom serdtsa.