Modulation of galactosamine-induced liver injury by some amino acids or Triton WR1339.
Galactosamine administration to rats (600 mg/kg, i.p.) produces a severe liver necrosis at 24 h. Pretreatment with cystine, tryptophan or methionine (600 mg/kg, p.o., 30 min before the hepatotoxin) significantly prevents galactosamine-induced liver necrosis. Glutamic or aspartic acids, however, were not protective under a similar dosage regimen. The prior administration of Triton WR1339 (1 g/kg, i.v., 30 min before galactosamine) significantly enhanced the liver response to galactosamine-induced liver injury, whereas the administration of tyrosine resulted in death of the animals.
D000596:Amino Acids / Q000627:therapeutic use*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D005688:Galactosamine / Q000037:antagonists & inhibitors*; D007521:Isocitrate Dehydrogenase / Q000097:blood; D008107:Liver Diseases / Q000517:prevention & control*; D008297:Male; D009336:Necrosis; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D011092:Polyethylene Glycols; D005688:Galactosamine; D007521:Isocitrate Dehydrogenase; C016811:tyloxapol