Kinetics of amyloid deposition. I. The effects of amyloid-enhancing factor and splenectomy.
It has long been recognized that amyloid AA deposition occurs in two phases, a predeposition and a deposition phase. The deposition phase has two distinct periods, a period of rapid deposition followed by a plateau stage. This kinetic pattern is seen in both liver and spleen and in animals in which the appearance of AA is accelerated by the administration of amyloid-enhancing factor. Amyloid-enhancing factor recipients have a shorter lag period before AA deposition is evident, but the kinetics of deposition and tissue level attained are similar to that seen in nonrecipients. It is also demonstrated that amyloid-enhancing factor activity may be generated in the liver of splenectomized animals.
D000682:Amyloid / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D002364:Caseins / Q000494:pharmacology; D005260:Female; D006023:Glycoproteins / Q000494:pharmacology*; D006651:Histocytochemistry; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D000685:Serum Amyloid A Protein / Q000378:metabolism; D013154:Spleen / Q000378:metabolism*; D013156:Splenectomy; D013997:Time Factors
D000682:Amyloid; D002364:Caseins; D006023:Glycoproteins; D000685:Serum Amyloid A Protein; C046748:amyloid enhancing factor; C026018:azocasein