Role of surface-active phospholipids in gastric cytoprotection.
Intragastric administration of a liposomal surfactant suspension markedly reduced acid-induced gastric ulcerogenesis and bleeding in rats. The concentration of surface-active molecules intrinsically present in the gastric mucosa was increased two to six times by administration of 16,16-dimethyl prostaglandin E2. Thus, local accumulation of surface-active phospholipids may be an integral component of the cytoprotective mechanism activated by prostaglandin treatment.
D000818:Animals; D005753:Gastric Mucosa / Q000502:physiology*; D007213:Indomethacin / Q000494:pharmacology; D010743:Phospholipids / Q000502:physiology*; D011453:Prostaglandins / Q000502:physiology; D051381:Rats; D013276:Stomach Ulcer / Q000503:physiopathology; D013501:Surface-Active Agents
D010743:Phospholipids; D011453:Prostaglandins; D013501:Surface-Active Agents; D007213:Indomethacin