title: Studies on the bioavailability of zinc in humans: intestinal interaction of tin and zinc.
abstract: Mineral/mineral interactions at the intestinal level are important in animal nutrition and toxicology, but only limited understanding of their extent or importance in humans has been developed. An inhibitory interaction of dietary tin on zinc retention has been recently described from human metabolic studies. We have explored the tin/zinc interaction using the change-in-plasma-zinc-concentration method with a standard dosage of 12.5 mg of zinc as zinc sulfate in 100 ml of Coca-Cola. Sn/Zn ratios of 2:1, 4:1, and 8:1, constituted by addition of 25, 50, and 100 mg of tin as stannous chloride, had no significant overall effect on zinc uptake. The 100-mg dose of tin produced noxious gastrointestinal symptoms. Addition of iron as ferrous sulfate to form ratios of Sn/Fe/Zn of 1:1:1 and 2:2:1 with the standard zinc solution and the appropriate doses of tin produced a reduction of zinc absorption not dissimilar from that seen previously with zinc and iron alone, and addition of picolinic acid did not influence the uptake of zinc from the solution with the 2:2:1 Sn/Fe/Zn ratio.
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D005296:Ferrous Compounds / Q000494:pharmacology; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D009753:Nutritive Value / Q000187:drug effects; D013997:Time Factors; D014001:Tin / Q000494:pharmacology*; D017971:Tin Compounds; D015032:Zinc / Q000097:blood / Q000378:metabolism*
chemical_list: D005296:Ferrous Compounds; D017971:Tin Compounds; C023599:stannous chloride; C020748:ferrous sulfate; D014001:Tin; D015032:Zinc