title: Dose and concentration dependence of chromosome aberrations in human cells and the combined action of radiation and chemical mutagens.
abstract: This paper describes a study of the combined effect of gamma-rays and N,N',N"-triethylenethiophosphoramide (thiotepa) on unstimulated leukocytes. The sequence of treatment and the interval between them (up to 4 h) do not affect the frequency of chromosome aberrations. In observing the combined effect of the mutagens, interaction of their effects was noted; however, quantitatively it does not differ significantly from the sum of their separately induced effects. Therefore, the elementary additivity model can be used to predict combined effects in the case of weak interactions. Exponential models for estimating combined effects based on a stepwise regression procedure are presented.
mesh_terms: D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects*; D008957:Models, Genetic; D009153:Mutagens / Q000494:pharmacology*; D013852:Thiotepa / Q000494:pharmacology
chemical_list: D009153:Mutagens; D013852:Thiotepa