The protective effect of polyriboinosinic acid-polyribocytidylic acid against the occurrence of galactosamine-induced liver cell injury in rat.
A marked increase of serum transaminase activities, histological changes of livers similar to those seen in viral hepatitis in man, and inhibition of hepatic protein synthesis were observed in rats following a single injection of D-galactosamine-HCl. These galactosamine-induced phenomena were prevented by the pretreatment of polyriboinosinic acid-polyribocytidylic acid 24 h before the galactosamine administration.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use* / Q000031:analogs & derivatives; D056486:Chemical and Drug Induced Liver Injury; D005688:Galactosamine / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008107:Liver Diseases / Q000473:pathology / Q000517:prevention & control; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives*; D009336:Necrosis; D010455:Peptides / Q000627:therapeutic use*; D011070:Poly I-C / Q000627:therapeutic use*; D011107:Polylysine / Q000627:therapeutic use* / Q000031:analogs & derivatives; D051381:Rats; D011919:Rats, Inbred Strains
D010455:Peptides; D011107:Polylysine; D005688:Galactosamine; C019531:poly ICLC; D008747:Methylcellulose; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D002266:Carboxymethylcellulose Sodium; D011070:Poly I-C