[Changes in heart rate and blood pressure in a series of normotensive subjects before and after beta-blocker treatment (double-blind) during physical, dynamic, static and psychosensorial stress].
23 normotensive subjects in good health are submitted to a "test de l'exposé" and 17 others are submitted to a test on an ergometric bicycle and a hand grip stress test. These tests are performed twice at one week interval, with or without treatment with acebutolol, in double blind. HR,SBP and DBP are measured simultaneously before, during and after each test. Every stress is responsible for a marked increase in the parameters according to different modalities. With ACEBUTOLOL treatment, during the test described and during dynamic stress on ergometric bicycle, HR and SBP are always less elevated. The decreases are dependent either on the stress level or on the reactivity of the subjects. DBP is however basely modified. Under static stress, there is a decrease in HR, in SBP, but also in DBP; actually increase in this parameter is important during this type of stress.
D000070:Acebutolol / Q000494:pharmacology*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D005082:Physical Exertion; D013312:Stress, Physiological / Q000503:physiopathology; D013315:Stress, Psychological / Q000503:physiopathology*
D000070:Acebutolol
Evolution des valeurs de la fréquence cardiaque et de la tension artérielle chez une série de sujets normotendus avant et après traitement par bêta-bloquants (double aveugle) lors de contraintes physiques, dynamiques, statiques et psycho-sensorielles.