title: Meiotic chromosomal translocations in male induced by X-irradiation.
abstract: The dose-response curve for reciprocal translocations induced by acute exposure of spermatogonial stem cells to X-rays in treated mice and their F-1 sons was examined. Male mice were totally irradiated with doses of 1 Gy; 5 X 1 Gy and 5 Gy. The obtained results show that frequency of the chromosomal translocations in directly treated animals is dose dependent. The percentage of animals irradiated with 1 Gy which had the chromosomal translocations was 60, while this percentage in animals irradiated with single and fractionated dose of 5 Gy was 100. The frequency of chromosomal translocations varies from 1.5% to 8.0%. Multivalent configurations in F-1 males were observed after exposure to 5 Gy only. The incidence of F-1 translocated males was 17.5%.
mesh_terms: D000818:Animals; D008297:Male; D008540:Meiosis / Q000528:radiation effects*; D051379:Mice; D008809:Mice, Inbred C3H; D011831:Radiation Genetics; D013093:Spermatogonia / Q000528:radiation effects*; D013094:Spermatozoa / Q000528:radiation effects*; D014178:Translocation, Genetic