[Implication of anterior hypothalamic dopamine in the regulation of arterial pressure].
The anterior hypothalamus is essential for the normal carotid sinus baroreceptor reflex. The dopamine innervation to this region is a projection from the dopaminergic A 14 cell group of the rostral hypothalamus. The anterior hypothalamic/preoptic region (AH/PO) was unilaterally superfused with buffer containing L-DOPA (10(-4) M) and the superfusate analyzed for dopamine using liquid chromatography with electrochemical detection. A stable release of dopamine was analyzed for dopamine using liquid chromatography with electrochemical detection. A stable release of dopamine was obtained within one hour. When the baroreceptor reflex loop was activated, a concomitant increase in dopamine release was observed. Lesions of the ventral noradrenergic bundle by a knife cut significantly increased the release of dopamine for at least two hours. The data are compatible with a tonic noradrenergic mechanism mediating an inhibitory control of dopamine release in the AH/PO. This dopaminergic involvement may play a functional role in blood pressure control.
D000818:Animals; D001794:Blood Pressure; D004298:Dopamine / Q000502:physiology*; D007031:Hypothalamus / Q000502:physiology*; D007032:Hypothalamus, Anterior / Q000187:drug effects / Q000502:physiology*; D007980:Levodopa / Q000494:pharmacology; D009638:Norepinephrine / Q000502:physiology*; D010293:Pargyline / Q000494:pharmacology; D011301:Preoptic Area / Q000502:physiology; D051381:Rats; D012018:Reflex / Q000502:physiology
D007980:Levodopa; D010293:Pargyline; D004298:Dopamine; D009638:Norepinephrine
Implication de la dopamine de l'hypothalamus antérieur dans la régulation de la pression artérielle.