title: Ir gene regulation of T cell proliferation: requirement for Ia and antigen expression on the same accessory cell.
abstract: These results demonstrate that only splenic macrophages expressing both Ir products (function) and the antigen (GAT) were able to reconstitute the T cell response of cultures in which the splenic macrophage monolayer had been treated with appropriate anti I-A antibodies. This inhibition was not a result of induced suppression caused by anti-Ia treatment but rather a masking of Ia antigen which prevents the T cell receptor(s) from recognizing either the Ir gene product and specific antigen in complex or separately.
mesh_terms: D000818:Animals; D000941:Antigens / Q000235:genetics*; D002478:Cells, Cultured; D005796:Genes; D005802:Genes, MHC Class II; D006168:Guinea Pigs; D006801:Humans; D007106:Immune Sera; D007518:Isoantibodies; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology*; D008285:Major Histocompatibility Complex; D051379:Mice; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000941:Antigens; D007106:Immune Sera; D007518:Isoantibodies