Inhibitory effect of imipramine on epinephrine-dependent platelet aggregation: "in vitro" studies on platelets from healthy and depressed people.
Inhibitory effect of imipramine on platelet aggregation in healthy and depressed people was studied. A different sensitivity was observed between healthy and depressed people. Two groups (D I and D II) were identified among depressed patients on the basis of sensitivity to imipramine effect. ID50 was calculated for healthy subjects (59.5 +/- 22 microM) and depressed patients (D I: 20 +/- 7 microM - D II: 117 +/- 49).
D000328:Adult; D000368:Aged; D003866:Depressive Disorder / Q000097:blood*; D004837:Epinephrine / Q000037:antagonists & inhibitors; D006801:Humans; D007099:Imipramine / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*
D007099:Imipramine; D004837:Epinephrine