title: Lack of effect of intravenous hypertonic glucose on the intensity of alcohol intoxication induced experimentally and observed in patients of an emergency room.
abstract: In the present paper, two experiments are performed to test the efficacy of the intravenous administration of hypertonic glucose (25 or 50%) in alcoholic intoxication. In a first experiment, 10 healthy, nonstarved volunteers, received 15 min after the ingestion of 1.0 g/kg alcohol, 40 ml of 25% glucose i.v., the same volume of 0.9% NaCl or no injection. According to evaluations performed at several time intervals up to 2 h after alcohol ingestion, no difference among the 3 conditions was observed either in the intensity of alcohol intoxication or on blood alcohol levels. In a second experiment, blood glucose and alcohol levels were evaluated in 80 alcoholized patients in an emergency room. The mean glycemic value was 94 mg/100 ml. No difference was found by comparing this value with that presented by nonalcoholized patients. The 80 patients were distributed in two groups of 40 each: one of them was intravenously administered 40 ml of glucose 50% while the other was injected with saline. About 20-30 min later the patients of both groups were clinically evaluated by the physician on duty, being considered equally improved regardless of the injection. The self-evaluation by the patients provided similar results.
mesh_terms: D000328:Adult; D000435:Alcoholic Intoxication / Q000188:drug therapy*; D001786:Blood Glucose / Q000378:metabolism; D004636:Emergency Service, Hospital; D000431:Ethanol / Q000097:blood; D005260:Female; D005947:Glucose / Q000627:therapeutic use*; D005950:Glucose Solution, Hypertonic / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D005950:Glucose Solution, Hypertonic; D000431:Ethanol; D005947:Glucose