A perspective on mechanisms of chromosomal mutations in relation to chromosome-stability-deficient mutants of Drosophila.
A working hypothesis that eukaryote chromosomal mutations result from specific misrecombination is proposed in relation to X-ray-induced mutations in the mouse. Unique features of chromosome-stability-deficient mutations and of tumor mutations in Drosophila are reviewed; these mutations could serve as very good models for elucidating the mechanisms of chromosome-aberration-related diseases in humans.
D000818:Animals; D002869:Chromosome Aberrations; D004260:DNA Repair; D004331:Drosophila melanogaster / Q000235:genetics*; D005799:Genes, Dominant; D005804:Genes, Lethal; D006801:Humans; D008297:Male; D008540:Meiosis; D009154:Mutation; D009369:Neoplasms / Q000235:genetics; D011995:Recombination, Genetic; D014178:Translocation, Genetic