Exposure to ethylene oxide at work increases sister chromatid exchanges in human peripheral lymphocytes.
Sister chromatid exchange rates increased significantly in the peripheral lymphocytes of a small group of hospital workers exposed to ethylene oxide for as little as 3.6 minutes per day regularly over a period of months. Results based on breathing zone exposure and task frequency estimates over a 6-month period for 14 workers suggest that sister chromatid exchanges are a sensitive indicator of exposure and that cumulative dose and dose rate are important predictors of sister chromatid exchange response.
D003434:Crossing Over, Genetic / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D005027:Ethylene Oxide / Q000633:toxicity*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D009784:Occupational Diseases / Q000139:chemically induced*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D005027:Ethylene Oxide