title: Effect of coronary vasodilation on ventricular fibrillation threshold: role of exogenous vasodilators and perfusion conditions.
abstract: Even without myocardial ischemia, coronary blood flow (CBF) constitutes a major determinant of ventricular fibrillation threshold (VFT). To clarify whether abnormal distribution of normal or increased CBF plays any additional role, 14 open-chest chloralose-anesthetized dogs with fixed-normalized heart rate, cardiac output, and systemic arterial pressure and separate servocontrolled left main coronary artery perfusion were studied as follows: VFT was determined first with coronary perfusion pressure (CPP) set at systemic level (80 mm Hg). Then CBF index was fixed at control levels (134.0 +/- 9.5 ml/min X 100 gm-1 LV) and coronary vasodilation was induced by intracoronary infusion of adenosine until CPP decreased to 49.0 +/- 2.0 mm Hg. Myocardial O2 consumption, LV pressure, LV dp/dt, and surface ECG remained unchanged. However, VFT decreased in all trials by about 45% (p less than 0.001). When CPP was reset to 80 mm Hg while maintaining vasodilation, CBF index increased by 90% to 255.4 +/- 15.4 ml/min X 100 gm-1 LV and VFT by 26% (p less than 0.005) from control. Yet these VFT increases in response to intraluminal pharmacologic vasodilation were about 19% (p less than 0.002) lower than expected for similar CBF index increases occurring physiologically. We conclude that intraluminal coronary vasodilation not matched by appropriate CBF increase results in substantial decrease of VFT. Moreover, at comparable increase of CBF, spontaneous physiologic vasodilation is more effective than intraluminal pharmacologic coronary vasodilation in increasing VFT.
mesh_terms: D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D003331:Coronary Vessels / Q000502:physiology; D004285:Dogs; D010101:Oxygen Consumption / Q000187:drug effects; D010477:Perfusion; D014665:Vasodilator Agents / Q000494:pharmacology*; D014693:Ventricular Fibrillation / Q000503:physiopathology*
chemical_list: D014665:Vasodilator Agents; D000241:Adenosine