[Effect of rutin on the cholesterol content of the lymph, blood and tissues of the dog].
It has been discovered in experiments on mongrel dogs anesthetized with morphine and hexenal that intravenous injection of rutin (3 mg/kg bw) reduced the concentration of total, esterified and free cholesterol in blood serum, with the exception of free cholesterol level in arterial blood, which increased. Under the same conditions, the concentration of free and esterified cholesterol in thoracic duct lymph ascended. In the popliteal lymph node, gastrocnemius muscle and liver, the content of total cholesterol appreciably dropped as compared to control. Rutin has been found to accelerate the lymph flow and to raise cholesterol resorption from the interstitial space. It is inferred that lymph plays an important part in cholesterol transport in the body.
D000818:Animals; D001158:Arteries; D001692:Biological Transport; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D004285:Dogs; D008196:Lymph / Q000378:metabolism*; D012431:Rutin / Q000494:pharmacology*; D014018:Tissue Distribution; D014680:Veins
D012431:Rutin; D002784:Cholesterol
Vliianie rutina na soderzhanie kholesterina v limfe, krovi i tkaniakh sobak.