Malignant hyperthermia in pigs: a search for abnormalities in Ca2+ binding proteins.
Malignant hyperthermia occurs in man and pigs as a hereditary disorder notably as a complication of halothane-induced anaesthesia. It involves an abnormality in the metabolism of Ca2+. A search was made for abnormalities of calcium-binding proteins. Troponin C from normal pig muscle was found to differ in 2 of 159 amino acids from rabbit Tn C and 3 from man. No differences between normal and abnormal pig muscle were found. Two-dimensional electrophoresis of red cell calmodulin from normal and abnormal pigs also failed to demonstrate a difference.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001480:Basal Ganglia Diseases / Q000235:genetics / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000032:analysis*; D002147:Calmodulin / Q000032:analysis; D006221:Halothane; D009132:Muscles / Q000032:analysis; D013552:Swine; D014336:Troponin / Q000032:analysis; D019209:Troponin C
D000596:Amino Acids; D002135:Calcium-Binding Proteins; D002147:Calmodulin; D014336:Troponin; D019209:Troponin C; D006221:Halothane