title: [Development of a splenic infection in mice of 4 strains, inoculated by the venous route, with 3 doses of Brucella abortus].
abstract: Brucella abortus strain 544 was inoculated at three doses into outbred female Swiss mice CD-1 and OF1, and inbred strains CBA and DBA/2. Brucella were enumerated in the mice spleens which were first weighed, at 2, 7, 14, 21, 35 and 49 days post-challenge. A phase of multiplication occurred, reaching a maximum between 7 and 21 days according to the mice, but independently of challenge doses. A decreasing phase followed that was still going on in CD-1 and OF1 mice at 49 days, but ended by a plateau or recurrence in CBA and DBA/2. Spleen weights increased from the beginning to a maximum then decreased. This maximum was reached either before (DBA/2), after (CBA) or at the infection acme (CD-1, OF1). Hence, immune mechanisms may be turned on according to several sequences, but feed-back regulation would work similarly in different breeds.
mesh_terms: D000818:Animals; D002003:Brucella abortus / Q000302:isolation & purification; D002006:Brucellosis / Q000276:immunology / Q000662:veterinary*; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D012376:Rodent Diseases / Q000276:immunology*; D013158:Splenic Diseases / Q000276:immunology / Q000662:veterinary*; D013163:Splenomegaly / Q000662:veterinary
vernacular_title: Evolution de l'infection splénique de souris de quatre lignées, inoculées par voie veineuse, par trois doses de Brucella abortus.