A comparison of clinical features in early- and late-onset primary degenerative dementia. One entity or two?
The prevalence of a number of clinical features occurring in patients with early- (before age 65) and late-onset primary degenerative dementia of the Alzheimer type (PDDAT) are compared. The data from a total of 65 patients demonstrated a greater prevalence of language disturbance, a disproportionate number of left-handers, and a much shorter relative survival time in the early-onset group. Taken together with other data, these findings indicate a degree of heterogeneity in the clinical features of patients with PDDAT and suggest a possible heightened selective vulnerability of the left hemisphere in early-onset cases. We interpret the data as raising the possibility that the current view of PDDAT as a unitary disorder may not be entirely valid.
D000368:Aged; D003704:Dementia / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D004292:Dominance, Cerebral; D007839:Functional Laterality; D006801:Humans; D007806:Language Disorders / Q000175:diagnosis / Q000473:pathology