Indication of reduced doxorubicin-induced cardiac toxicity by additional treatment with antioxidative substances.
The influence of antioxidative substances on doxorubicin-induced cardiac toxicity was studied in C 57 BL mice. Tocopherol (500 mg/kg), glutathione (1000 mg/kg), cysteamine (15 mg/kg) and L-cysteine (1000 mg/kg), injected i.p. 24 h before doxorubicin treatment (15 mg/kg i.p.) were able to reduce malonaldehyde production in cardiac tissues significantly. SH-containing substances with high reducing activity, such as vitamin E, could be a useful tool in clinical trials to prevent doxorubicin induced cardiac damage.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003543:Cysteamine / Q000494:pharmacology; D003545:Cysteine / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology*; D005978:Glutathione / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000096:biosynthesis; D051379:Mice; D008810:Mice, Inbred C57BL; D009206:Myocardium / Q000378:metabolism*; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D014810:Vitamin E; D008315:Malondialdehyde; D003543:Cysteamine; D004317:Doxorubicin; D005978:Glutathione; D003545:Cysteine