The effect of intracerebroventricularly administered octopamine, phenylethylamine and epinephrine on the central serotonergic system of the rat.
Octopamine (OCT, 50-250 micrograms) and epinephrine (EPI, 10-100 micrograms) given intracerebroventricularly (icvtr) antagonized the head twitch response induced in the rat by 5-hydroxytryptophan or 5-methoxytryptamine, and hyperthermia induced by quipazine in rats kept at high ambient temperature. Phenylethylamine [PEA, 10-100 micrograms] did not change the action of serotonergic stimulants. OCT, PEA and EPI significantly depressed the cerebral level of serotonin [5-HT], and OCT also reduced the concentration of 5-hydroxyindoleacetic acid. OCT depressed, while EPI slightly accelerated the 5-HT turnover rate; PEA practically did not affect the turnover. The results indicate that OCT and EPI given icvtr to rats antagonize the central serotonergic system.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001679:Biogenic Amines / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D009655:Octopamine / Q000494:pharmacology; D010627:Phenethylamines / Q000494:pharmacology; D011814:Quipazine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*
D001679:Biogenic Amines; D010627:Phenethylamines; D009655:Octopamine; C029261:phenethylamine; D012701:Serotonin; D011814:Quipazine; D006916:5-Hydroxytryptophan; D004837:Epinephrine