Pathogenesis of pes cavus in Charcot-Marie-Tooth disease.
Of 22 persons from a single kinship of known Charcot-Marie-Tooth (CMT) disease, 12 were found to be affected. All 12 had a pes cavus deformity. The insidious atrophy of the intrinsic musculature of the foot progressed to a fixed soft tissue and bony cavus deformity.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002607:Charcot-Marie-Tooth Disease / Q000150:complications* / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D005260:Female; D005531:Foot Deformities, Acquired / Q000209:etiology*; D005684:Gait; D005799:Genes, Dominant; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology; D009133:Muscular Atrophy / Q000150:complications*; D010375:Pedigree