title: Vertebral bone loss: an unheeded side effect of therapeutic bed rest.
abstract: 1. The skeletal effects of simple bed rest and re-ambulation were studied in a consecutive series of 34 patients (aged 18-60 years) hospitalized with low backache due to protrusion of a lumbar intervertebral disc. The bone mineral content of the second, third and fourth lumbar vertebrae was determined by dual-photon (153Gd) absorptiometry immediately after admission to the hospital, at the end of the bed-rest period (mean 27 days, range 11-61 days) and approximately 15 weeks later (range 11-24 weeks). 2. During recumbency a mean decrease in lumbar spine bone mineral content of 0.9% per week was observed. 3. Re-ambulation resulted in bone mineral gain, and restoration of lumbar spine bone mineral content was nearly complete after 4 months. 4. The findings suggest that the simple therapeutic bed-rest regimen leads to excessive vertebral bone loss. Recurrent bed-rest periods may predispose to spinal osteoporosis.
mesh_terms: D000293:Adolescent; D000328:Adult; D001510:Bed Rest / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000628:therapy; D008124:Locomotion; D008159:Lumbar Vertebrae / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000032:analysis*; D010024:Osteoporosis / Q000209:etiology* / Q000378:metabolism; D013997:Time Factors
chemical_list: D008903:Minerals