The inhibitory effect of dilazep on in vivo accumulation of platelets onto the damaged aorta in rabbit. II. Morphological analysis.
The inhibitory effect of dilazep on platelet adhesion and aggregation onto the damaged aorta was morphologically investigated using an animal model of thrombosis in which polyethylene tubing was inserted into the rabbit aorta in order to injure the intima. Rabbits were divided into 2 groups, control and dilazep-treated groups. The aortas 60 minutes after insertion of tubing were examined by light, scanning and transmission electron microscopy. An amount of adhered and aggregated platelets onto the exposed subendothelial surface of the aorta in rabbits pretreated with dilazep 100 micrograms/kg was significantly less than in control rabbits. Fibrin formation was also sparse in the mural thrombi in dilazep-treated group compared to that in control group. The results show that dilazep has the definite inhibitory effect in early mural thrombogenesis following the endothelial denudation in rabbit.
D000818:Animals; D001011:Aorta / Q000293:injuries; D001381:Azepines / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D004109:Dilazep / Q000494:pharmacology*; D005342:Fibrinolysis / Q000187:drug effects; D005343:Fibrinolytic Agents; D008297:Male; D010973:Platelet Adhesiveness / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits
D001381:Azepines; D005343:Fibrinolytic Agents; D004109:Dilazep