Drugs and visual perception: effects of LSD, morphine and chloropromazine on accuracy, bias and speed.
Ten pigeons were trained to discriminate between the intensities of two white lights (projected behind a center response "key") using a discrete trial procedure in which choice behavior involved pecking at red or green lights projected behind left or right side keys. LSD (0.02-0.08 mg/kg) did not alter the accuracy of the brightness discrimination (percent correct) although it did lower response speed and may have differentially affected spatial (position) bias. Morphine (2.5--10.0 mg/kg) decreased accuracy of discrimination as well as response speed and had greater effects on trials when the bright stimulus was presented than when the dim stimulus was presented. Chlorpromazine (7.5-3.0 mg/kg) lowered accuracy without significantly altering any other measure of performance.
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D003118:Color Perception / Q000187:drug effects; D010856:Columbidae; D004193:Discrimination Learning / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D013028:Space Perception / Q000187:drug effects; D014796:Visual Perception / Q000187:drug effects*
D009020:Morphine; D008238:Lysergic Acid Diethylamide; D002746:Chlorpromazine