Opposite effects of chlordiazepoxide and serotonin receptor antagonists on morphine-induced locomotor stimulation in mice.
Chlordiazepoxide and two serotonin receptor antagonists showed opposite effects when tested for their influence on morphine-induced locomotor stimulation in mice. Chlordiazepoxide enhanced morphine-induced hyperactivity, which was antagonized by cyproheptadine and mianserin. The results indicate that the enhancement of morphine-induced locomotor stimulation is not attributable to an antiserotonergic action of the benzodiazepine compound.
D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology*; D003533:Cyproheptadine / Q000494:pharmacology*; D003984:Dibenzazepines / Q000494:pharmacology*; D008297:Male; D008803:Mianserin / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects*
D003984:Dibenzazepines; D011985:Receptors, Serotonin; D008803:Mianserin; D003533:Cyproheptadine; D002707:Chlordiazepoxide; D009020:Morphine