Difluoromethylornithine enhancement of putrescine uptake into the prostate: concise communication.
We studied the effect of alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, on putrescine uptake by the rat prostate. Using C-14 putrescine, we found a several-fold increase in uptake by both the dorsal and ventral prostates of DFMO-pretreated intact animals, compared with untreated controls. When previously castrated animals were treated with a combination of testosterone and DFMO, the prostatic uptake of exogenously administered C-14 putrescine increased more than tenfold. Under these conditions, DFMO enhanced the uptake by the prostate to a greater extent than by any other tissue studies.
D000818:Animals; D002369:Castration; D000518:Eflornithine; D008297:Male; D009952:Ornithine / Q000031:analogs & derivatives* / Q000494:pharmacology; D065108:Ornithine Decarboxylase Inhibitors; D011467:Prostate / Q000201:enzymology / Q000378:metabolism*; D011700:Putrescine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011920:Rats, Inbred WF
D065108:Ornithine Decarboxylase Inhibitors; D009952:Ornithine; D011700:Putrescine; D000518:Eflornithine