title: Effects of erythromycin, aminoglycosides and doxycycline on mucociliary activity in vitro of rabbit trachea.
abstract: The effect of different antibiotics on the mucociliary activity of the upper respiratory tract of rabbit was tested in vitro. Erythromycin base had no effect, although erythromycin lactobionate had a minor inhibitory effect. Kanamycin and gentamicin had no inhibitory effect in high concentrations. Doxycycline had the highest mucociliary inhibitory effect; however, the toxic concentrations are more than 10 times the clinically relevant serum levels after oral administration.
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002923:Cilia / Q000187:drug effects*; D004318:Doxycycline / Q000494:pharmacology*; D004917:Erythromycin / Q000494:pharmacology*; D066298:In Vitro Techniques; D009092:Mucous Membrane / Q000187:drug effects; D011817:Rabbits; D012137:Respiratory System / Q000187:drug effects*; D012965:Sodium Chloride / Q000494:pharmacology; D013997:Time Factors; D014132:Trachea / Q000187:drug effects
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D012965:Sodium Chloride; D004917:Erythromycin; D004318:Doxycycline