Identification and origins of neutral fecal sterols in adult Large White sows: occurrence of externally-secreted intestinal cholesterol.
Cholesterol, the main neutral fecal sterol (54-84 p. 100) in adult Large White sows fed a controlled semi-purified diet containing 0.08 p. 100 cholesterol (500 g twice a day; 3 510 kcal/day), was partially converted into coprostanol (10-44 p. 100). Exceptionally, epicoprostanol was present, indicating a second pathway of bacterial cholesterol degradation. In this paper, the term "fecal cholesterol" is restricted to the sum of cholesterol + coprostanol. The contribution of fecal cholesterol to the bulk of neutral fecal sterols eliminated daily, averaged 97 +/- 1 p. 100. For a given dietary cholesterol intake of 80 mg per day, eliminated fecal cholesterol was estimated to be 392 +/- 47 mg/day and mean fecal cholesterol concentration 1.88 +/- 0.12 mg/g of stools. The various sources of fecal cholesterol were unabsorbed ingested cholesterol, cholesterol excreted from the plasma, and externally-secreted intestinal cholesterol, synthesized by the digestive tract, discharged into the lumen and not absorbed. The respective contributions of these different sources were as follows: unabsorbed dietary cholesterol 34 +/- 2 mg/day, excreted cholesterol 234 +/- 28 mg/day and externally-secreted cholesterol 125 +/- 23 mg/day.
D000818:Animals; D004083:Cholestanol / Q000032:analysis; D002784:Cholesterol / Q000032:analysis / Q000378:metabolism*; D005243:Feces / Q000032:analysis*; D005260:Female; D007413:Intestinal Mucosa / Q000378:metabolism*; D007810:Lanosterol / Q000031:analogs & derivatives / Q000032:analysis; D010840:Phytosterols / Q000032:analysis; D013261:Sterols / Q000032:analysis*; D013552:Swine
D010840:Phytosterols; D013261:Sterols; D007810:Lanosterol; C015316:lanostenol; D004083:Cholestanol; D002784:Cholesterol