Lack of dominant lethal effects in male CD-1 mice after short-term and long-term exposures to vinyl chloride monomer.
Dominant lethal studies were conducted with vinyl chloride monomer (VCM) in male CD-1 mice, using short-term (10 000 ppm, 4 h/day, for 5 days) and long-term (5000 ppm, 4 h/day, 5 day/week, for 10 weeks) exposures. There was no evidence of dominant lethal effects due to VCM in either case. Semen examination of male mice after long-term exposure failed to reveal any alteration in sperm motility and shape. Sporadic appearance of giant cells was observed in the testes of males exposed to VCM, but was not considered to affect spermatogenesis.
D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects; D010064:Embryo Implantation / Q000187:drug effects; D005020:Ethyl Methanesulfonate / Q000494:pharmacology; D005260:Female; D005799:Genes, Dominant / Q000187:drug effects*; D005804:Genes, Lethal / Q000187:drug effects*; D008297:Male; D051379:Mice; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D014752:Vinyl Chloride / Q000633:toxicity*; D014753:Vinyl Compounds / Q000633:toxicity*
D014753:Vinyl Compounds; D005020:Ethyl Methanesulfonate; D014752:Vinyl Chloride