[Effect of choriogonine on the enzymatic activity of lysosomes in the cirrhotic liver in the rat].
Liver tissue cirrhosis, developed in rats after long-term administration of CCl4, led to distinct increase in activities of acid phosphatase, acid DNAase, cathepsin D, beta-galactosidase and beta-glucosidase. When the treatment with the hepatotropic toxins was stopped activity of lysosomal enzymes decreased slightly but was maintained at the high level. Within a day after a single administration of choriogonine distinct decrease as compared with the controls in activity of all the acid hydrolases studied was found. Within subsequent periods the lysosomal enzymes activity continued to decrease and within 2 months after the choriogonine treatment it was distinctly lower as compared with control animals.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications; D002403:Cathepsins / Q000378:metabolism; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D003851:Deoxyribonucleases / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008106:Liver Cirrhosis, Experimental / Q000201:enzymology* / Q000209:etiology; D008115:Liver Regeneration; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D051381:Rats; D001616:beta-Galactosidase / Q000378:metabolism; D001617:beta-Glucosidase / Q000378:metabolism
D006063:Chorionic Gonadotropin; D003851:Deoxyribonucleases; D000135:Acid Phosphatase; D001617:beta-Glucosidase; D001616:beta-Galactosidase; D002403:Cathepsins
Vliianie khoriogonina na fermentativnuiu aktivnost' lizosom v tsirroticheski izmenennoĭ pecheni krws.