[Effects of adrenaline on the functional state of liver lysosomes and serum hydrolase activity in severe mechanical trauma].
The effect of hyperreactivity of the sympathoadrenal system on rat liver lysosomal function during severe mechanical injury induced by compression of soft tissues was studied. Parenteral administration of adrenaline before the animals were exposed to the injury produced no qualitative differences in the response to the lysosomal injury of the organ under study. The response manifested in quantitative alterations--activation of the test lysosomal hydrolases and impairment of membrane stability followed by release of the enzymes to the hepatocyte cytoplasm and then to the systemic circulation.
D000135:Acid Phosphatase / Q000097:blood; D000818:Animals; D001192:Arylsulfatases / Q000097:blood; D003851:Deoxyribonucleases / Q000378:metabolism; D004837:Epinephrine / Q000502:physiology*; D006867:Hydrolases / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012260:Ribonucleases / Q000378:metabolism; D014947:Wounds and Injuries / Q000201:enzymology*
D006867:Hydrolases; D003851:Deoxyribonucleases; D012260:Ribonucleases; D000135:Acid Phosphatase; D001192:Arylsulfatases; D004837:Epinephrine
Vliianie adrenalina na funktsional'noe sostoianie lizosom pecheni, aktivnost' gidrolaz v syvorotke krovi krys pri tiazheloĭ mekhanicheskoĭ travme.