Nuclear DNA content of clear cell adenocarcinoma of the vagina and cervix and its relationship to prognosis.
A study was performed to determine if ploidy levels of nuclear DNA content could be used as a prognostic index of the biologic behavior of clear cell adenocarcinoma of the vagina and cervix in young females. Forty tumors were examined. Four patterns of nuclear DNA distribution were identified: (1) peridiploid stem cell lines (2N to 3N); (2) peritetraploid stem cell lines (3N to 5N); (3) hypertetraploid stem cell lines (greater than 5N); and (4) highly aneuploid without detectable stem cell lines. Tumors having peridiploid and peritetraploid stem cell lines (low ploidy group) were most often clinical Stage I or II (87%) and were in general associated with a favorable prognosis. Tumors having hypertetraploid stem cell lines and highly aneuploid distribution (high ploidy group) were usually clinical Stage III or IV (65%). Clinically advanced tumors (Stage III or IV) had poor prognosis irrespective of ploidy level. Among the clinical Stage I and II tumors, the low ploidy group had a slightly better prognosis than the high ploidy group. This difference, however, was not statistically significant.
D000230:Adenocarcinoma / Q000032:analysis*; D000293:Adolescent; D000328:Adult; D002453:Cell Cycle; D002460:Cell Line; D002467:Cell Nucleus / Q000032:analysis; D002648:Child; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D011123:Polyploidy; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000032:analysis*; D014625:Vaginal Neoplasms / Q000032:analysis*
D004273:DNA, Neoplasm