Tumor promoting activity of 1,8-dihydroxy-3-methyl-9-anthrone (chrysarobin) in female SENCAR mice.
Purified 1,8-dihydroxy-3-methyl-9-anthrone or chrysarobin was found to be an effective skin tumor-promoter in SENCAR mice, although, at the dose used, it was approximately 43-fold less active than 12-O-tetradecanoylphorbol-13-acetate (TPA). When non-promoting doses of chrysarobin were applied 30 min prior to each application of TPA, a marked potentiation in the promoting response to TPA was observed. Chrysarobin will provide a valuable tool for studying the mechanism of action of anthracene-derived mouse skin tumor promoters.
D000818:Animals; D000873:Anthracenes / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000473:pathology; D010212:Papilloma / Q000139:chemically induced / Q000473:pathology; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology; D013755:Tetradecanoylphorbol Acetate
D000873:Anthracenes; D002273:Carcinogens; C013883:chrysarobin; D013755:Tetradecanoylphorbol Acetate