A correlation between protein thermostability and resistance to proteolysis.
The loss of activity due to proteolysis of purified L-asparaginase and beta-galactosidase from different sources correlates with the thermal instability of the enzymes. A similar correlation is found when populations of soluble proteins from micro-organisms grown at different temperatures are compared for proteolytic susceptibility and thermal stability. It is proposed that there is a general correlation between the thermostability of proteins and their resistance to proteolysis.
D001215:Asparaginase / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism*; D006358:Hot Temperature; D011489:Protein Denaturation; D001616:beta-Galactosidase / Q000378:metabolism
D001426:Bacterial Proteins; D001616:beta-Galactosidase; D001215:Asparaginase