In vitro activities of trimethoprim and sulfamethoxazole against Listeria monocytogenes.
The in vitro activities of trimethoprim and sulfamethoxyazole against clinical isolates of Listeria monocytogenes were examined separately and in combination with a microtiter broth dilution system. Sulfamethoxazole demonstrated variable activity and was generally bacteriostatic. Trimethoprim alone was bactericidal against 96% of isolates at less than 0.5 microgram/ml. The bactericidal action of trimethoprim against L. monocytogenes was generally potentiated by sulfamethoxyazole even when isolates were relatively resistant to sulfamethoxyazole alone.
D006801:Humans; D008089:Listeria monocytogenes / Q000187:drug effects*; D008088:Listeriosis / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D013420:Sulfamethoxazole / Q000494:pharmacology*; D013997:Time Factors; D014295:Trimethoprim / Q000494:pharmacology*
D014295:Trimethoprim; D013420:Sulfamethoxazole