[Disorder of the contractile function of the nonischemic portion of the heart in experimental infarct and its prevention by the phospholipase inhibitor chloroquine].
Contractility of an isolated rat right auricle was studied one day after producing one day after producing experimental infarction in the left cardiac region, there was a pronounced decrease in elasticity, and contractility was depressed, which manifested in an approximately two-fold decline in the developing tension. These originally stress-induced disturbances were prevented by administering the phospholipase inhibitor chloroquine to the animals prior to infarction. The data obtained indicate that activation of phospholipases might play a role in contractility disturbances of cardiac nonischemized regions under infarction.
D000818:Animals; D002738:Chloroquine / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004789:Enzyme Activation / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology*; D010740:Phospholipases / Q000037:antagonists & inhibitors*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains
D002738:Chloroquine; D010740:Phospholipases; D010741:Phospholipases A
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