title: Study of adjuvant and mitogenic activities of bacterial peptidoglycans with different structures.
abstract: The adjuvant and mitogenic properties of bacterial peptidoglycans (PG) of different structures have been compared. The PG from Bacillus megaterium and Staphylococcus aureus were adjuvant-active in the guinea-pig, and mitogenic for guinea-pig and mouse lymphocytes. On the other hand the PG from Micrococcus lysodeikticus and Corynebacterium poinsettiae exerted neither adjuvant nor mitogenic activities. Mitogenic PG were selective B mitogens. They were mitogenic for splenocytes from Nude mice and inactive towards T-cell-enriched populations. They were mitogenic in both germ-free mice and in the C3H/HeJ strain which is unresponsive to lipopolysaccharide.
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D001410:Bacillus megaterium / Q000276:immunology; D003352:Corynebacterium / Q000276:immunology; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008819:Mice, Nude; D008837:Micrococcus / Q000276:immunology; D008934:Mitogens / Q000494:pharmacology*; D010457:Peptidoglycan / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D008934:Mitogens; D010457:Peptidoglycan