[Systolic arterial hypertension: demonstration and mechanism in obliterating arteriopathy of the lower extremities].
Hemodynamic parameters were measured in 24 patients with arteriosclerosis obliterans of the lower limbs, in comparison with 16 normal subjects of same age. Systemic arterial compliance was estimated from a simple visco-elastic model. In patients with arteriosclerosis obliterans, systolic pressure was significantly increased (P less than 0.001) while diastolic pressure remained within normal ranges. Arterial compliance was reduced (P less than 0.01) and was negatively correlated with systolic pressure (r = -0.72). Intravenous administration of nitroglycerin significantly decreased systolic pressure (P less than 0.05) and increased arterial compliance (P less than 0.01) without any change in mean arterial pressure. This study provided evidence that, in patients with arteriosclerosis obliterans of the lower limbs, the reduced systemic arterial compliance contributes in the increase in systolic pressure.
D001157:Arterial Occlusive Diseases / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D001158:Arteries / Q000503:physiopathology; D003187:Compliance; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D007866:Leg / Q000098:blood supply*; D008875:Middle Aged; D005996:Nitroglycerin / Q000627:therapeutic use
D005996:Nitroglycerin
Hypertension artérielle systolique: mise en évidence et mécanisme dans l'artériopathie oblitérante des membres inférieurs.