Haplotype-specific suppression of T cell response to lactate dehydrogenase B in (responder x nonresponder)F1 mice.
Mouse strains that express the Ek (Ek beta E-1k alpha) molecule are nonresponders (NR) to the enzyme lactate dehydrogenase B (LDHB) in terms of T cell proliferation. Nonresponsiveness is caused by T suppressor (Ts) cells recognizing LDHB in the context of Ek molecules on the antigen-presenting cells. The data presented here demonstrate that the Ek-restricted Ts cells function in (R x NR)F1 mice in a remarkable haplotype-specific fashion: they selectively interfere with the Ak (ANR)-restricted response, and do not affect the response channeled through the A molecules of the responder parent. This haplotype-specificity of suppression provides an explanation of the dominance of responsiveness in (R x NR)F1 mice.
D000818:Animals; D000950:Antigens, Ly / Q000276:immunology; D005802:Genes, MHC Class II; D005808:Genes, Recessive; D007108:Immune Tolerance; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D000950:Antigens, Ly; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase