Resistance to Klebsiella pneumoniae and the importance of two bacterial antigens.
The resistance of mice to a lethal infection with Klebsiella pneumoniae, type I, was investigated. Antibody of both IgG and IgM class produced good protection when given with an intra-nasal inoculum of the organism. While antibody directed against capsular antigens was highly protective, so too was antibody directed against a second, non-capsular and heat-labile antigen. This antigen does not appear to be related to either the K or O antigens of Klebsiella and is present in several strains of Klebsiella. It is suggested that this antigen may play a role in determining resistance to this organism by humans.
D000042:Absorption; D000818:Animals; D000942:Antigens, Bacterial / Q000032:analysis / Q000145:classification / Q000276:immunology*; D001428:Bacterial Vaccines / Q000528:radiation effects / Q000627:therapeutic use; D004797:Enzyme-Linked Immunosorbent Assay; D005976:Glutaral / Q000494:pharmacology; D006358:Hot Temperature; D007106:Immune Sera / Q000276:immunology; D007113:Immunity, Innate; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D007710:Klebsiella Infections / Q000276:immunology* / Q000628:therapy; D007711:Klebsiella pneumoniae / Q000276:immunology / Q000472:pathogenicity; D051379:Mice; D014774:Virulence
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D007106:Immune Sera; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005976:Glutaral