Estimation of local kinetic parameters of exchange of lithium in various substructures of the mouse brain, using the 6Li(n, alpha)3H-nuclear reaction.
The time-constant of lithium (Li)-clearance from the plasma was of the order of 2 hr, while the mean time-constant of lithium-clearance from the bulk of the body cells into the plasma was about 10 times this value. The mean time-constant of lithium ion (Li+)-clearance from various brain substructures (corpus callosum, striatum, hippocampus, neocortex) was comparable to the latter (15-25 hr). Comparison of samples where either a slight diffusion or no diffusion at all had occurred, suggest that between the nerve bodies and the trunks, lithium ions are not uniformly distributed.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D006207:Half-Life; D007554:Isotopes; D007700:Kinetics; D008094:Lithium / Q000097:blood / Q000378:metabolism*; D008297:Male; D051379:Mice; D014316:Tritium
D007554:Isotopes; D014316:Tritium; D008094:Lithium