Cerebral involvement in dehydration-induced natriuresis.
Water deprivation caused daily urinary Na output to more than double in normal sheep, but caused no increase in Na excretion in sheep (A3VL-sheep) in which the anterior third ventricle wall had been ablated. Dehydrated A3VL-sheep exhibited a much greater degree of hypernatremia than dehydrated normal sheep, although water losses were similar in both groups. We postulate that the natriuresis induced by dehydration is a cerebrally mediated homeostatic response.
D000818:Animals; D002552:Cerebral Ventricles / Q000503:physiopathology*; D003681:Dehydration / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006955:Hypernatremia / Q000209:etiology; D009318:Natriuresis; D009994:Osmolar Concentration; D012756:Sheep; D012964:Sodium / Q000097:blood
D012964:Sodium