[Effect of moderate protein deficiency on reproduction in the female rat and on the development of the pups until weaning].
Two groups of Wistar female rats were respectively fed ad libitum a standard stock diet containing 22 p. 100 protein (n = 93) and a diet containing 7.5 p. 100 protein (n = 189) for 8 weeks. They were mated with male rats of the same strain after 2 weeks of these diets. A small decrease (8 p. 100) in fecundity was observed but this moderate protein deprivation did not affect either the litter size (9.68 +/- 3.50 vs 9.61 +/- 3.69) or the percentage of stillborn pups (4.8 vs 4.9 p. 100). The postnatal mortality of the pups of deprived dams was much higher than that of pups from normal dams (11.2 vs 0.9 p. 100). During the suckling period, the 7.5 p. 100 protein diet did not cover the requirements of the dams. They lost 20 p. 100 of their weight, whereas the weight of the dams fed the 22 p. 100 protein diet remained stable. The weight deficit of the young rats born from deprived dams was about 10 p. 100 at birth but it rose to 50 p. 100 at weaning. During the gestation and suckling periods, the maternal body stores and tissues were mobilized to assure the growth of the young.
D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D001835:Body Weight; D004044:Dietary Proteins / Q000008:administration & dosage; D005260:Female; D005298:Fertility; D008098:Litter Size; D008297:Male; D011247:Pregnancy; D011502:Protein-Energy Malnutrition / Q000503:physiopathology / Q000662:veterinary*; D051381:Rats; D011919:Rats, Inbred Strains / Q000254:growth & development*; D012098:Reproduction; D012376:Rodent Diseases / Q000503:physiopathology*; D014886:Weaning
D004044:Dietary Proteins
Effet d'une carence protéique modérée sur la reproduction chez la rate et sur le développement des jeunes jusqu'au sevrage.