title: Malignant Brenner tumor of the ovary. Electron microscopic study of a case responsive to radiation and chemotherapy.
abstract: A patient with malignant Brenner tumor of the ovary is presented. The tumor responded to combined therapy with radiation plus doxorubicin + cyclophosphamide despite earlier failure on a single alkylating agent (levophenylalanine mustard). The patient next exhibited a brief response to chemotherapy with hexamethylmelamine + cyclophosphamide + amethopterin + 5-fluorouracil. The histologic findings and ultrastructure of the tumor are discussed in detail. The morphologic features are consistent with the proposed origin of Brenner tumors from coelomic epithelium through a process of secondary urothelial metaplasia.
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001485:Basement Membrane / Q000648:ultrastructure; D001772:Blood Cell Count; D001948:Brenner Tumor / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D004359:Drug Therapy, Combination; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D008871:Microvilli / Q000648:ultrastructure; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy
chemical_list: D000970:Antineoplastic Agents