Propagation of focal cortical epileptiform discharge to the entopeduncular nucleus: effect of caudate lesions.
Single-unit recordings were made in the entopeduncular nucleus of cats which had previously undergone ipsilateral caudate lesions. During penicillin-induced epileptiform discharge from the pericruciate cortex, the percentage of responsive entopeduncular neurons in animals with a lesion was less than 20%. In a previous study in intact cats and in control experiments in the present study the percentage of responsive entopeduncular cells was more than 75%. These results indicate that propagation of epileptic discharge through the basal ganglia depends on intact pathways from the cortex to the caudate and from the caudate to the entopeduncular nucleus.
D000818:Animals; D002415:Cats; D002421:Caudate Nucleus / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D004558:Electric Stimulation; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D005917:Globus Pallidus / Q000503:physiopathology*; D009474:Neurons / Q000502:physiology; D010406:Penicillins
D010406:Penicillins