title: Successful treatment of extremely brittle, insulin-dependent diabetes with a novel subcutaneous insulin pump regimen.
abstract: Brittle, insulin-dependent diabetic patients with extremely labile glucose control requiring frequent hospitalizations were treated with a continuous subcutaneous insulin infusion delivered with a programmable pump. As reported by others, the patients did not improve with a regimen of preprandial boluses superimposed on a continuous single-rate infusion. However, they demonstrated dramatic clinical and metabolic improvement with a modified pump regimen that delivered a variable square-wave insulin infusion and avoided any boluses. These very difficult patients can benefit by insulin pump therapy.
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D016883:Diabetic Ketoacidosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage; D007332:Insulin Infusion Systems; D008297:Male; D008875:Middle Aged
chemical_list: D007328:Insulin