[Chronicity of non-A, non-B hepatitis. Evaluation of the clinical course with special reference to the types of distribution of HLA antigens and clinical criteria].
The progression of acute viral hepatitis non-A, non-B in a group of young female patients with well defined disease was evaluated retrospectively over a period of 21/2 years. The histologically proved chronification rate was 39 per cent. It was looked for a correlation between some parameters in the acute phase of the disease, the distribution of HLA antigens, and the progression to chronicity. There were no statistically ensured differences of HLA antigens between patients with chronic hepatitis non-A, non-B, patients with healed acute one, patients with chronic hepatitis type B, and the normal population. The level of transaminases within the acute phase of the illness did not allow to draw any conclusion for the further progression of the disease. But icteric patients seemed to develop chronic disease more seldom. In this time, the reason of the high chronification rate after infection by hepatitis virus(es) non-A, non-B is not yet clear.
D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006509:Hepatitis B / Q000276:immunology; D006526:Hepatitis C / Q000276:immunology*; D006525:Hepatitis, Viral, Human / Q000276:immunology*; D006801:Humans; D012189:Retrospective Studies
D006680:HLA Antigens
Zur Chronifizierung der Hepatitis Non-A, Non-B. Verlaufsbeurteilung unter besonderer Berücksichtigung des HLA-Antigen-Verteilungstyps und klinischer Kriterien.