title: [Role of lipid peroxidation in the regulation of liver microsomal monooxygenase activity in homoiothermic animals exposed to cold].
abstract: The reaction rates of N-demethylation of aminopyrine, p-hydroxylation of aniline and hydroxylation of 3,4-benzo(a)pyrene in liver microsomes were determined in rats exposed to severe cold (-7 degrees C) for a long time (8 days). The data obtained demonstrate the decreased activities of 3,4-benzo(a)pyrene hydroxylase and aniline hydroxylase. There were no distinct alterations in aminopyrine N-demethylase activity. The increased levels of NADPH- and ascorbate-dependent microsomal lipid peroxidation together with impairment of the soluble antioxidant glutathione system are considered in animals exposed to cold as a possible mechanism of monooxygenase activity deterioration in liver microsomes.
mesh_terms: D000633:Aminopyrine N-Demethylase / Q000378:metabolism*; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D001833:Body Temperature Regulation; D003080:Cold Temperature; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006900:Hydroxylation; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism; D008862:Microsomes, Liver / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D008054:Lipid Peroxides; D008563:Membrane Lipids; D008315:Malondialdehyde; D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases; D000633:Aminopyrine N-Demethylase
vernacular_title: Rol' perekisnogo okisleniia lipidov v reguliatsii aktivnosti mikrosomal'nykh monooksigenaz pecheni gomoĭotermnykh zhivotnykh pri kholodovom vozdeĭstvii.