title: Investigation of circular asymmetry in cancer mortality of Hiroshima and Nagasaki A-bomb survivors.
abstract: Data on Hiroshima and Nagasaki A-bomb survivors are used to investigate, for each city, possible circular asymmetry in cancer mortality around the hypocenter. Using the Cox regression method and controlling for age ATB, sex, followup year, distance from the hypocenter, and type of shielding, it is found that in Hiroshima cancer mortality was significantly higher in the westerly direction from the hypocenter. Mortality from stomach cancer, leukemia, and colon cancer were higher in the westerly direction. In Nagasaki, only lung cancer exhibited circular asymmetry, and was significantly higher in the westerly direction. For various reasons, the results tend to support the possibility of an asymmetry in radiation dose in Hiroshima, but not in Nagasaki. Also, possible asymmetry in nondose variables associated with cancer is suggested in both cities, particularly in variables associated with lung cancer. Indications for future work and implications for future dose-mortality investigations are discussed.
mesh_terms: D000367:Age Factors; D000392:Air Movements; D004781:Environmental Exposure; D006801:Humans; D007564:Japan; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology* / Q000401:mortality; D009689:Nuclear Warfare; D011829:Radiation Dosage; D012044:Regression Analysis; D012737:Sex Factors