Amelanotic changes in B 16 melanoma after transplantation to 'Yellow' Ay/a mice.
B 16 mouse melanoma maintained on nonagouti a/a mice (C 57 Bl 6j subline) was transplanted to 'Yellow' Ay/a mutants. B 16 melanoma has now been maintained for 1 year on the 'Yellow' strain. A microscopic and ultrastructural study of transplanted tumors is described. Several enzymatic activities including tyrosinases are investigated. A marked depigmentation of the B 16 melanoma is noted after its transplantation to the 'Yellow' strain, and melanogenic characteristics of the tumor are modified.
D000818:Animals; D005260:Female; D007527:Isoenzymes / Q000032:analysis; D008297:Male; D008545:Melanoma / Q000201:enzymology / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008854:Microscopy, Electron; D014442:Monophenol Monooxygenase / Q000032:analysis; D009368:Neoplasm Transplantation; D010860:Pigments, Biological / Q000032:analysis
D007527:Isoenzymes; D010860:Pigments, Biological; D014442:Monophenol Monooxygenase