Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216.
The benzodiazepine antagonists Ro 15-1788 and CGS 8216 blocked the clonic and tonic convulsions elicited by 3-carbomethoxy-beta-carboline (beta-CCM). The PD50 values for Ro 15-1788, CGS 8216, and diazepam were: 2.0, 0.6, and 2.0 mg/kg, respectively. Neither Ro 15-1788 nor CGS 8216 potentiated the effect of a threshold convulsant dose of beta-CCM. Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another beta-carboline, harmaline. Diazepam, however, considerably reduced the tremorigenic actions of this drug.
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D002243:Carbolines / Q000037:antagonists & inhibitors*; D003292:Convulsants / Q000037:antagonists & inhibitors*; D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005442:Flumazenil; D006246:Harmaline / Q000494:pharmacology; D007211:Indoles / Q000037:antagonists & inhibitors*; D008297:Male; D051379:Mice; D011720:Pyrazoles / Q000494:pharmacology*; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*; D014202:Tremor / Q000139:chemically induced
D001570:Benzodiazepinones; D002243:Carbolines; D003292:Convulsants; D007211:Indoles; D011720:Pyrazoles; D005442:Flumazenil; C033830:2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one; D006246:Harmaline; C036150:beta-carboline-3-carboxylic acid methyl ester; D003975:Diazepam