Double-blind comparison of the respiratory and sedative effects of codeine phosphate and (+/-)-glaucine phosphate in human volunteers.
1 Two antitussive agents (+/-)-glaucine phosphate and codeine phosphate have been compared with placebo with respect to ventilation, ventilatory response to carbon dioxide, pulse, blood pressure, digit symbol substitution, sedation score and the Zahlen-Verbindung test performance in ten healthy volunteers (22-36 years). The study was double-blind and the two doses of each antitussive agent and the placebo were administered as a syrup. 2 Both codeine phosphate and (+/-)-glaucine phosphate displaced the ventilatory response to carbon dioxide to the right. 3 The effect of codeine phosphate on the ventilatory response to carbon dioxide was not dose dependent: 30 mg produced greater effects than the 60 mg dose. 4 Only the highest dose of (+/-)-glaucine phosphate (60 mg) caused respiratory depression and this was associated with sedation and decreased performance in the digit symbol substitution test. 5 Neither antitussive agent had significant effects upon pulse or blood pressure and codeine phosphate had no detectable sedative activity.
D000328:Adult; D000996:Antitussive Agents / Q000009:adverse effects*; D001060:Aporphines / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000494:pharmacology; D003061:Codeine / Q000009:adverse effects*; D004311:Double-Blind Method; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D011674:Pulse / Q000187:drug effects; D012119:Respiration / Q000187:drug effects*; D013997:Time Factors
D000996:Antitussive Agents; D001060:Aporphines; D006993:Hypnotics and Sedatives; D002245:Carbon Dioxide; C005004:glaucine; D003061:Codeine