title: [Changes in the pancreas after obliteration of the pancreatic ducts in a dog with Hydron].
abstract: The development of pancreatic changes was studied after obliteration of pancreatic ducts by means af 2-hydroxyethylmethacrylate. The drug was injected into the main pancreatic duct of 15 dogs that were put to death successively and examined by histology. Necrosis of pancreatic duct epithelium was found in 4 days after the polymer administration in addition to focal periductal necrosis of acinar tissue and interstitial oedema with fibroblast activation. Later, a rapid development of fibrosis occurred which ensue in an extinction of exocrine tissue after 2 months. Pancreas consisted then but of connective tissue and cumulated Langerhans' islets with positive beta-granulations. Pancreatic ducts obliteration is a reliable method for selective inhibition of exocrine activity.
mesh_terms: D000818:Animals; D003251:Constriction, Pathologic; D004285:Dogs; D010179:Pancreas / Q000378:metabolism / Q000473:pathology*; D010183:Pancreatic Ducts / Q000473:pathology / Q000503:physiopathology*; D011102:Polyhydroxyethyl Methacrylate
chemical_list: D011102:Polyhydroxyethyl Methacrylate
vernacular_title: Zmĕny pankreatu po obliteraci pankreatických vývodů u psa Hydronem.