[Isolation of a monokine with a macrophage replacing activity for the induction of the antibody response to sheep red blood cells in vitro].
Macrophages are required for the induction of the immune response in vitro; it is known, however, that in the case of a particulate antigen such as red blood cells, macrophages can be replaced by a culture supernatant obtained from peritoneal cells. In the present paper we have studied the compound responsible for this activity, and compared it with the monokine Interleukine 1 obtained from activated macrophages: it has a different molecular weight: 35 K instead of 15 K and, in contrast with Interleukine 1, this compound is without effect on the proliferation of thymocytes.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D004912:Erythrocytes / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D008970:Molecular Weight; D015846:Monokines; D011506:Proteins / Q000302:isolation & purification*; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology*
D015846:Monokines; D011506:Proteins
Isolement d'une monokine capable de remplacer les macrophages dans l'induction de la réponse immunitaire in vitro aux globules rouges de mouton.