Relationship of triglyceride levels to thrombosis in patients with coronary artery disease.
The relationship of triglyceride levels to coagulation abnormalities was studied in 43 patients, who were divided into two groups. Group 1 consisted of patients with triglyceride levels less than 200 mg% (range, 75 to 190 mg%), and Group 2 consisted of patients with triglyceride levels greater than 250 mg% (range, 255 to 890 mg%). Analysis of the data revealed that patients with high triglyceride levels also have a high incidence of low antithrombin III activity and increased platelet aggregation. It is likely that hyperlipidemic patients are more prone to thrombosis of diseased coronary arteries or saphenous vein bypass grafts, and should definitely be placed on appropriate anticoagulants.
D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D000990:Antithrombin III / Q000032:analysis; D001778:Blood Coagulation Disorders / Q000097:blood* / Q000188:drug therapy; D003327:Coronary Disease / Q000097:blood* / Q000188:drug therapy; D005260:Female; D005340:Fibrinogen / Q000502:physiology; D006801:Humans; D006949:Hyperlipidemias / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D011446:Prospective Studies; D013925:Thromboplastin / Q000032:analysis; D013927:Thrombosis / Q000097:blood; D014280:Triglycerides / Q000097:blood*
D000925:Anticoagulants; D014280:Triglycerides; D000990:Antithrombin III; D005340:Fibrinogen; D013925:Thromboplastin