Ineffectiveness of chemotherapy in patients with metastatic ependymoma of the cauda equina.
Six cases of intraspinal ependymoma metastasizing outside the central nervous system have been reported. This report documents a seventh case. This patient received multiple courses of combination and single-agent chemotherapy without evidence of tumor regression. All seven patients had four things in common: early onset of disease, numerous operations, massive local recurrence at the time distant metastases were noted, and a long time period from diagnosis to death.
D000293:Adolescent; D000328:Adult; D002420:Cauda Equina; D002648:Child; D003520:Cyclophosphamide / Q000627:therapeutic use; D003961:Dianhydrogalactitol / Q000627:therapeutic use; D004806:Ependymoma / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D010524:Peripheral Nervous System Neoplasms / Q000473:pathology* / Q000601:surgery; D011344:Procarbazine / Q000627:therapeutic use; D012673:Semustine / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D012673:Semustine; D011344:Procarbazine; D003961:Dianhydrogalactitol; D014750:Vincristine; D003520:Cyclophosphamide