Antimicrobial activity of 3-methyl-5-furfurylidene-2-thioxo-4-thiazolidones.
Substituted 3-methyl-5-furfurylidene-2-thioxo-4-thiazolidones 1-17 were tested for their action against Bacillus pumilus, B. brevis and B. megaterium and against Aspergillus flavus, A. fumigatus and A. niger. Most of the compounds possessed an activity against both bacteria and fungi. These compounds were also tested for their effectiveness as virus inhibitors employing Nicotiana glutinosa as assay host against tobacco mosaic virus. Most of them exhibited potential antiviral activity both in vitro and in vivo.
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects*; D001407:Bacillus / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000494:pharmacology*; D014027:Tobacco Mosaic Virus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000998:Antiviral Agents; D013844:Thiazoles