Enhancement of mitogenic stimuli by phosphatidylinositol.
Phosphatidylinositol added to the medium markedly stimulated the growth-promoting effect of mitogens in normal cells (human lymphocytes and mouse embryo fibroblasts). However, it did not significantly affect quiescent cells or proliferating tumor cell lines (HeLa and MCF-7). The results are consistent with the suggested role of phosphatidylinositol in the widespread mechanism of calcium mobilization.
D000230:Adenocarcinoma / Q000503:physiopathology; D000818:Animals; D001943:Breast Neoplasms / Q000503:physiopathology; D002460:Cell Line; D002478:Cells, Cultured; D004261:DNA Replication / Q000187:drug effects; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000502:physiology; D006367:HeLa Cells / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007700:Kinetics; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008934:Mitogens / Q000494:pharmacology*; D010716:Phosphatidylinositols / Q000494:pharmacology*
D008934:Mitogens; D010716:Phosphatidylinositols