title: The impact of adenine and inventory utilization decisions on blood inventory management.
abstract: The use of citrate-phosphate-dextrose-adenine as an anticoagulant for whole blood increases the storage period permitted for whole blood and red cells from 21 to 35 days. A simulation model was used to analyze the possible consequences for outdates and shortages of the addition of adenine. The model accepts as input (1) the maximum age (21 or 35 days), (2) parameters describing the demand and supply distributions, and (3) parameters describing inventory control (crossmatch recycle period, transfusion fraction, deviation from optimal target inventory levels). These parameters were varied over wide ranges, and a full factorial design was carried out. The observed shortage and outdate rates were then related (via multiple regression) to the parameter values. The resulting shortage and outdate functions indicated the effect of parameter changes, including extending the lifetime from 21 to 35 days, and the joint effect of changing more than one parameter. Conclusions indicate that, while the contribution of an increased lifetime to reducing shortages and outdates can be substantial, this contribution can be easily dissipated by relaxing the tightness of other inventory management controls.
mesh_terms: D000225:Adenine / Q000494:pharmacology*; D000925:Anticoagulants / Q000494:pharmacology; D001771:Blood Banks / Q000458:organization & administration; D001788:Blood Grouping and Crossmatching; D001793:Blood Preservation; D001803:Blood Transfusion / Q000706:statistics & numerical data*; D002951:Citrates / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D007445:Inventories, Hospital / Q000379:methods*; D008421:Materials Management, Hospital / Q000379:methods*; D008954:Models, Biological; D010710:Phosphates / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000925:Anticoagulants; C034876:CPDA solutions; D002951:Citrates; D010710:Phosphates; D005947:Glucose; D000225:Adenine