title: Biologic effect of a hybrid preparation of human chorionic gonadotropin in human subjects.
abstract: Alpha and beta-hCG subunits were recombined generating a hybrid hCG preparation (AB1ER-CR-2XY) which met the required specifications of a pharmaceutical product. The biologic activity contained in each vial of AB1ER-CR-2XY was equivalent to 10 000IU of hCG-IS. This preparation was given as a single dose of 10 000IU by the i.m. route to four female subjects presenting unexplained infertility. The hCG hybrid was demonstrated to effect gonadal stimulation in humans.
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006728:Hormones / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000188:drug therapy*; D008596:Menotropins / Q000008:administration & dosage; D008598:Menstruation / Q000187:drug effects; D010053:Ovary / Q000187:drug effects; D055503:Protein Multimerization
chemical_list: D006063:Chorionic Gonadotropin; D006728:Hormones; D008596:Menotropins