Behavioural evidence for partial agonist properties of RO 15-1788, a benzodiazepine receptor antagonist.
Rats trained to discriminate pentylenetetrazol from saline had this cue antagonized by the benzodiazepine, clorazepate. Ro 15-1788 reversed the antagonism of the pentylenetetrazol cue produced by clorazepate. Similarly, Ro 15-1788 blocked the anti-conflict effect of clorazepate. Rats trained to discriminate clorazepate from saline, however, generalized this cue to Ro 15-1788. These results demonstrate that Ro 15-1788 is not a pure benzodiazepine antagonist, but has partial agonist properties.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001570:Benzodiazepinones / Q000494:pharmacology*; D003009:Clorazepate Dipotassium / Q000494:pharmacology; D003220:Conflict, Psychological / Q000187:drug effects; D003463:Cues / Q000187:drug effects; D004192:Discrimination, Psychological / Q000187:drug effects*; D005442:Flumazenil; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology; D051381:Rats
D001570:Benzodiazepinones; D005442:Flumazenil; D003009:Clorazepate Dipotassium; D010433:Pentylenetetrazole