[Adaptation of energy metabolism of liver and muscles in the rabbit to hypobaric hypoxia].
The adaptation of rabbits to hypobaric hypoxia results in stable changes in energy metabolism. During posthypoxic recovery the levels of ATP and ATP+ADP in the liver are decreased, while the Pi content and the cytosolic NAD+/NADH ratio are increased; the steady state concentrations of glucose, pyruvate, lactate and adenine nucleotides and the rate of glycolysis are increased after hypoxic exposure. Succinate oxidation by liver mitochondria from hypoxia-adapted rabbits is accelerated as compared to normal animals; however, the coupling, rate and efficiency of oxidative phosphorylation remain unchanged. At enhanced gluconeogenesis all the parameters of phosphorylating succinate oxidation are impaired. Possible pathways of energy supply for gluconeogenesis are discussed.
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D004734:Energy Metabolism; D006019:Glycolysis; D000860:Hypoxia / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D010084:Oxidation-Reduction; D011312:Pressure; D011817:Rabbits
D000227:Adenine Nucleotides; D009243:NAD
Adaptatsiia énergeticheskogo obmena v pecheni i myshtsakh u krolika k vysotnoĭ gipoksii.