Suppression of PHA-induced IFN-gamma production in BALB/c mice.
In the present paper we report some evidences of negative genetic control of the IFN-gamma production following stimulation with phytohaemagglutinin both in vivo and in vitro. C3H mice were good IFN-gamma producers whereas BALB/c and (BALB/c X C3H) F1 mice were non producers. The distribution of the capacity to produce significant levels of IFN-gamma in [(C3H X BALB/c) X (C3H X BALB/c)] F2 mice is compatible with the hypothesis of a pleomorphic negative control.
D000818:Animals; D007371:Interferon-gamma / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D010835:Phytohemagglutinins / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects
D010835:Phytohemagglutinins; D007371:Interferon-gamma