Enzymatic synthesis of the 2',5'-A4 tetramer analog, 2',5'-ppp3'dA(p3'dA)3, by rabbit reticulocyte lysates: binding and activation of the 2',5'-A eta dependent nuclease, hydrolysis of mRNA, and inhibition of protein synthesis.
D000818:Animals; D002848:Chromatography, DEAE-Cellulose; D003838:Deoxyadenine Nucleotides / Q000378:metabolism*; D004722:Endoribonucleases / Q000378:metabolism* / Q000494:pharmacology; D004789:Enzyme Activation; D009841:Oligonucleotides / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000187:drug effects; D012333:RNA, Messenger / Q000378:metabolism*; D011817:Rabbits; D012156:Reticulocytes / Q000378:metabolism; D012260:Ribonucleases / Q000378:metabolism* / Q000494:pharmacology
D003838:Deoxyadenine Nucleotides; D009841:Oligonucleotides; D012333:RNA, Messenger; C030108:(2'-5')-3'-deoxyadenosine triphosphate-3'-deoxyadenosine monophosphate; D004722:Endoribonucleases; D012260:Ribonucleases; C034663:ppp(A2'p)nA-dependent endoribonuclease protein, mouse