1,2,3-Triazole derivatives of aryloxyalanoic acids.
Several 1,2,3-triazolederivatives of aryloxyalcanoic acids of general formula (II) were synthesized. Some derivatives were obtained by the cycloaddition reaction of 4-azidophenoxyacetic acid (III) to activated methylene compounds, but the largest part were prepared by nucleophilic substitution reactions of three new (4-hydroxyphenyl)triazole derivatives and alyphatic bromoesters. Some compounds, tested as prostaglandin-synthetase inhibitors of rat spleen in vitro, showed practically no activity; moderate activities as herbicides, insecticides and antimicrobials were detected.
D000818:Animals; D001419:Bacteria / Q000187:drug effects; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors; D006540:Herbicides / Q000138:chemical synthesis; D066298:In Vitro Techniques; D007306:Insecticides / Q000138:chemical synthesis; D051381:Rats; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D002264:Carboxylic Acids; D016861:Cyclooxygenase Inhibitors; D006540:Herbicides; D007306:Insecticides; D014230:Triazoles