Free and lipid inositol, sorbitol and sugars in sciatic nerve obtained post-mortem from diabetic patients and control subjects.
Sciatic nerves removed post-mortem from diabetic patients and normal subjects were analysed by gas chromatography for glucose, fructose, sorbitol and myo-inositol. The concentrations of free and lipid inositol were significantly lower in nerves from the diabetic than from the control group. Concentrations of glucose, fructose and sorbitol were higher in the nerves of the diabetic patients.
D000368:Aged; D050260:Carbohydrate Metabolism; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D005632:Fructose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D012584:Sciatic Nerve / Q000378:metabolism*; D013012:Sorbitol / Q000378:metabolism*
D005632:Fructose; D007294:Inositol; D013012:Sorbitol; D005947:Glucose