title: Recurrent vulvar malignancies in an 11-year prospectively followed vulvar distrophy: a gynecologist's permanent concern.
abstract: This case reports on a vulvar lichen sclerosus, followed during 11 years, with poor response to many different local and general treatments. After 6 years of control the patient developed a mild atypia. Two years later, an invasive carcinoma was diagnosed and radically treated. Six months later, a local recurrence was excised. During the last year of control new biopsies of the neovulva showed, at different times, carcinoma in situ and severe atypia.
mesh_terms: D002278:Carcinoma in Situ / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D011446:Prospective Studies; D012598:Sclerosis; D013997:Time Factors; D014844:Vulva / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000601:surgery*