Study on the effect of superoxide dismutase on arachidonic acid metabolism.
The effect of orgotein, the drug version of bovine Cu-Zn superoxide dismutase, on PG production by phagocytosing leukocytes has been investigated. Orgotein inhibited PG formation in a dose/dependent manner. Arachidonic acid was able to reverse this inhibitory effect. In the light of these results it is suggested that anti-inflammatory properties of orgotein may depend, at least in part, on the inhibition of phospholipase activation.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000097:blood*; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism*; D008667:Metalloproteins / Q000494:pharmacology; D010587:Phagocytosis; D011453:Prostaglandins / Q000097:blood; D051381:Rats; D013482:Superoxide Dismutase / Q000494:pharmacology*
D001095:Arachidonic Acids; D008667:Metalloproteins; D011453:Prostaglandins; D016718:Arachidonic Acid; D013482:Superoxide Dismutase; C005180:orgotein