Ascorbic acid and its effect on the skin of Bufo regularis.
Skin papillomas were observed in the majority of toads when painted with 1 mg of 7,12-dimethyl-benz (alpha) anthracene (DMBA) dialy for 8 weeks. Animals injected with 10 mg/kg/day of ascorbic acid into the dorsal lymph sac showed tumor inhibition when painted with the same dose level of DMBA for 8 weeks. Tumor regression occurred in those animals receiving 10 mg/kg/day of ascorbic acid for 8 weeks.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use*; D002025:Bufonidae; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy; D010212:Papilloma / Q000139:chemically induced / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy*
D015127:9,10-Dimethyl-1,2-benzanthracene; D001205:Ascorbic Acid