Mianserin, maprotiline and the electroencephalogram.
1 EEGs were recorded from patients with depressive illness before and after four weeks of treatment with mianserin, maprotiline or placebo. 2 Visual analysis of the records showed a small but statistically significant increase in frequency of beta activity in the mianserin group. 3 One subject taking maprotiline developed spike and wave discharges but had no convulsive seizures. 4 The findings do not support those of previous studies. It seems that changes seen in the EEG early after treatment are not sustained for four weeks.
D000328:Adult; D000873:Anthracenes / Q000009:adverse effects*; D003984:Dibenzazepines / Q000009:adverse effects*; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D008376:Maprotiline / Q000009:adverse effects* / Q000627:therapeutic use; D008803:Mianserin / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged
D000873:Anthracenes; D003984:Dibenzazepines; D008803:Mianserin; D008376:Maprotiline