Naloxone attenuates the hypotension induced by Hageman factor.
The hypotension induced in the pentobarbital anesthesized rat by the i.v. administration of an active Hageman factor fragment (Hff) is significantly attenuated by naloxone. This effect is specific because the opiate antagonist does not modify the hypotension elicited by rat urinary kallikrein, bradykinin or nitroglycerin. These results suggest that the contact activation of endogenous Hageman factor could result in the generation of vasoactive opioid peptides derived from circulating large molecular weight precursors.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001920:Bradykinin / Q000494:pharmacology; D004347:Drug Interactions; D005174:Factor XII / Q000494:pharmacology*; D015956:Factor XIIa; D007610:Kallikreins / Q000494:pharmacology; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D005996:Nitroglycerin / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013618:Tachyphylaxis
D010446:Peptide Fragments; D009270:Naloxone; D005174:Factor XII; D007610:Kallikreins; D015956:Factor XIIa; D005996:Nitroglycerin; D001920:Bradykinin