Acute global ischaemia and nitroglycerine-induced changes of the contraction-relaxation and diastolic properties of isolated rabbit heart.
In our previous studies on in situ dog hearts it has been shown that nitroglycerine has a direct myocardial effect. It was suggested that nitroglycerine is involved, besides its negative inotropic action, in active relaxation and passive diastolic properties of the heart [2, 24]. In some aspects nitroglycerine seems to be in synergy with the effect of coronary ligation. The purpose of the present study was confirmation and evaluation of the nature of the supposed direct myocardial effect of nitroglycerine, and comparison in this action with that of acute arrest of coronary perfusion in rabbit heart.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000503:physiopathology*; D005260:Female; D009126:Muscle Relaxation / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D005996:Nitroglycerin / Q000494:pharmacology*; D051381:Rats
D005996:Nitroglycerin