In vitro activity of cefoxitin, alone and in combination with aminoglycoside or other beta-lactam antibiotics against common gram-negative pathogens.
We examined 160 strains of Enterobacteriaceae and Pseudomonas aeruginosa for susceptibility to cefoxitin, aminoglycosides, and other beta-lactam antibiotics, alone and in combination. The aminoglycosides were the most effective agents tested, but, except for some strains, cefoxitin inhibited all organisms at a 90% minimal inhibitory concentration of 25 micrograms or less per ml. We observed a relatively high incidence of antagonism or nonsynergy when cefoxitin was tested in combination with other agents against 33 gentamicin-susceptible gram-negative bacilli. No synergy was observed when various combinations with cefoxitin were tested against three strains of cephalothin-resistant, carbenicillin-resistant Enterobacteriaceae of varying gentamicin susceptibility.
D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002440:Cefoxitin / Q000494:pharmacology*; D004347:Drug Interactions; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002440:Cefoxitin