Evidence for the presence of specific binding sites for transcortin in human liver plasma membranes.
Binding sites which recognize and bind specifically asialotranscortin and the native transcortin-cortisol complex have been found in plasma membranes of human liver cells. The native conformation of transcortin is an absolute requirement for the binding reaction of the transcortin-hormone complex. Sex-hormone-binding globulin and thyroxine-binding globulin from human serum do not bind to this binding sites.
D001665:Binding Sites; D002462:Cell Membrane / Q000378:metabolism; D005260:Female; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008297:Male; D014156:Transcortin / Q000378:metabolism*
D006023:Glycoproteins; D014156:Transcortin