[Occurrence of malignant non-Hodgkin lymphoma after long-term azathioprine therapy of chronic polyarthritis].
The case is presented of a female patient with rheumatoid arthritis, in whom a malignant non-Hodgkin lymphoma developed following long-term treatment with azathioprine. The possibility of an increased incidence of malignant lymphomas in immunological disorders, including rheumatoid arthritis, is discussed, as is the question of the extent to which azathioprine therapy might be involved in this. Some pathogenetic mechanisms of the development of malignant lymphomas are also considered.
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000139:chemically induced*; D008134:Long-Term Care
D001379:Azathioprine
Auftreten eines malignen Non-Hodgkin-Lymphomes nach Azathioprin-Langzeittherapie einer chronischen Polyarthritis.