Demonstration of vascular redistribution after carotid clamping in rats.
In Long Evans rats, the vertebral arteries supply only the brain stem. Simultaneous application of clamps to both carotid arteries results in a considerable fall of cerebral blood flow and eventually death. If an interval of about 4 days is allowed between the clamping of the 2 carotids, redistribution of blood flow takes place. Owing to this mechanism, 50% of the rats survive with a satisfactory restoration of cerebral blood flow.
D000818:Animals; D002339:Carotid Arteries / Q000502:physiology*; D002560:Cerebrovascular Circulation; D003250:Constriction; D008297:Male; D051381:Rats; D012039:Regional Blood Flow; D013997:Time Factors