Isoprenaline increases brain concentrations of administered L-dopa and L-tryptophan in the rat.
A small dose of isoprenaline or saline was administered intraperitoneally to rats 20 min before the administration of one of the amino acids L-dopa or L-tryptophan. Isoprenaline caused a marked increase in the brain concentration of the administered amino acid. Isoprenaline has previously been shown to cause a decrease in at least some of those plasma amino acids which compete with L-dopa and tryptophan for carrier-mediated transport into the brain. The effect of isoprenaline on the concentrations of dopa and tryptophan in the brain is suggested to be at least partly caused by a change in the relationship between endogenous and administered amino acids. It is also possible that a direct effect of isoprenaline on the blood-brain barrier transport system contributes to the effect. The reported finding might be of clinical interest in view of the therapeutic importance of aromatic amino acids with a central site of action.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology*; D007980:Levodopa / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014364:Tryptophan / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism
D014443:Tyrosine; D007980:Levodopa; D014364:Tryptophan; D007545:Isoproterenol; D004298:Dopamine