Methylphenidate decreases local glucose metabolism in the motor cortex.
The local cerebral metabolism on glucose (l-CMRg) was evaluated in animals given methylphenidate (15 mg/kg) in order to investigate possible mechanisms of action of the drug. Significant increases in l-CMRg (p greater than 0.05) were found in the globus pallidus, entopeduncular nucleus, substantia nigra, subthalamic nucleus, inferior olive, red nucleus, lateral cerebellar cortex, ventral lateral nucleus of the thalamus and the midbrain reticular formation. Significant decreases (p greater than 0.05) in l-CMRg were found in the motor cortex. These results suggest possible mechanisms for methylphenidate's action in attention deficit disorders.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology*; D009044:Motor Cortex / Q000187:drug effects / Q000378:metabolism*; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D014851:Wakefulness / Q000502:physiology
D008774:Methylphenidate; D005947:Glucose