Extensive proliferative capacity of haematopoietic stem cells.
The proliferative capacity of the presumed pluripotent haematopoietic stem cell (CFUs) was assessed. Repeated (monthly) depletion of this cell population vivo by the alkylating agent TEM was followed by repopulation of the haematopoietic system. The cumulative number of doublings of the CFUs population was estimated to be about 158. It is therefore concluded that either the CFUs do not represent the stem cell population; or, any intrinsic lifespan must be beyond this number of cell doublings.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000502:physiology; D002455:Cell Division / Q000187:drug effects; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000502:physiology*; D007700:Kinetics; D051379:Mice; D008815:Mice, Inbred Strains; D014265:Triethylenemelamine / Q000494:pharmacology
D014265:Triethylenemelamine