The influence of isolation and aminooxyacetic acid (AOAA) on GABA in muricidal rats.
The influence of isolation was studied on the development of muricidal behavior and on brain GABA. GABA was significantly lower in several parts of the limbic system of brain taken from muricidal rats, when compared to their non-muricidal counterparts. Isolation potentiated the development of muricidal behavior and lowered GABA levels. Administration of aminooxyacetic acid (AOAA) resulted in a preferential elevation of GABA in the olfactory lobes. Muricidal behavior was inhibited during the AOAA-induced increase in GABA.
D000085:Acetates / Q000494:pharmacology*; D000374:Aggression / Q000187:drug effects; D000625:Aminooxyacetic Acid / Q000494:pharmacology*; D000679:Amygdala / Q000187:drug effects; D000818:Animals; D001921:Brain / Q000187:drug effects*; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects; D008032:Limbic System / Q000187:drug effects; D008297:Male; D009115:Muridae; D009830:Olfactory Bulb / Q000187:drug effects; D012934:Social Isolation; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000085:Acetates; D000625:Aminooxyacetic Acid; D005680:gamma-Aminobutyric Acid