Formaldehyde and hexamethylenetetramine in Styles' cell transformation assay.
A dose-dependent increase in the transformation rate in Styles' cell transformation assay using BHK-21/cl.13 cells was observed after exposure to formaldehyde and hexamethylenetetramine. The toxic and transforming effect was equal after exposure to 20 micrograms/ml of formaldehyde or 1000 micrograms/ml of hexamethylenetetramine which is slowly hydrolysed in aqueous solution to form ammonia and formaldehyde.
D000818:Animals; D002273:Carcinogens; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002471:Cell Transformation, Neoplastic; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005557:Formaldehyde / Q000633:toxicity*; D007668:Kidney; D008709:Methenamine / Q000633:toxicity*
D002273:Carcinogens; D005557:Formaldehyde; D008709:Methenamine