The effects of cholestyramine, colestipol, and ADR-132 on the rat prostate and dunning R-3327 adenocarcinoma.
The effects of three compounds known to have hypocholesterolemic activity in several species were investigated on the rat prostate and the hormone-dependent R-3327 rat prostatic adenocarcinoma. Cholestyramine, colestipol, and ADR-132 are bile acid-sequestering anion exchange resins which were fed to separate groups of adult male Copenhagen X Fischer (F1) hybrid rats in doses of 0.25%, 1.00%, and 2.00% of diet. The results indicate that serum cholesterol levels in tumor-bearing rats and controls fed these compounds for 29 days were not reduced. The body and organ weights as well as the histological features of the prostate gland, seminal vesicles, and the R-3327 tumor were unaffected by these agents.
D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D000837:Anion Exchange Resins / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D002792:Cholestyramine Resin / Q000627:therapeutic use*; D003084:Colestipol / Q000627:therapeutic use*; D007475:Ion Exchange Resins / Q000627:therapeutic use*; D008297:Male; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009929:Organ Size / Q000187:drug effects; D011073:Polyamines / Q000627:therapeutic use*; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D051381:Rats; D011916:Rats, Inbred F344; D012117:Resins, Synthetic
D000837:Anion Exchange Resins; D007475:Ion Exchange Resins; D011073:Polyamines; D012117:Resins, Synthetic; D002792:Cholestyramine Resin; C037750:ADR 132; D003084:Colestipol