Complementation analysis of dexamethasone resistance in L cells.
Glucocorticoid-resistant variants of L cells were characterized by somatic cell hybridization. Neither of the variants had a clearly dominant phenotype in hybrids with a glucocorticoid-sensitive fibroblast line. Hybrids of one of the resistant variants and a resistant fibroblast line showed complementation--the hybrid clones were sensitive to dexamethasone. Complementation, however, disappeared after continued culture of the hybrid cells.
D000818:Animals; D002999:Clone Cells; D004261:DNA Replication; D003907:Dexamethasone / Q000494:pharmacology*; D004351:Drug Resistance; D005816:Genetic Complementation Test; D014644:Genetic Variation; D007739:L Cells / Q000187:drug effects / Q000502:physiology; D051379:Mice
D003907:Dexamethasone