Effect of hormone treatment on spontaneous and radiation-induced chromosomal breakage in normal and dwarf mice.
Treatment of dwarf mice with growth hormone, insulin and testosterone had no effect on the spontaneous frequencies of micronuclei (MN) in bone-marrow cells, whereas thyroxine decreased these frequencies. The induction of MN by X-rays and mitomycin C was significantly lower in dwarf mice than in normal mice. Treatment with thyroxine plus growth hormone restored normal radiosensitivity in dwarfs.
D000818:Animals; D001854:Bone Marrow Cells; D002875:Chromosomes / Q000187:drug effects* / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology; D006728:Hormones / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology; D008297:Male; D051379:Mice; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D009152:Mutagenicity Tests; D009153:Mutagens; D013739:Testosterone / Q000494:pharmacology; D013974:Thyroxine / Q000494:pharmacology
D006728:Hormones; D007328:Insulin; D008937:Mitomycins; D009153:Mutagens; D013739:Testosterone; D016685:Mitomycin; D013006:Growth Hormone; D013974:Thyroxine