Effects of salicylate and 2,4-dinitrophenol on respiration and metabolism.
The respiratory and metabolic responses to intravenous administration of sodium salicylate (240 mg/kg0.75) and 2,4-dinitrophenol (5.7 mg/kg0.75), uncouplers of oxidative phosphorylation, were studied in anesthetized, paralyzed, vagotomized, and glomectomized cats. During the initial 10 min after administration of salicylate, metabolic rate (VCO2) increased 70% and did not increase further during the experiment. Respiration, on the other hand, increased progressively at the same rate over the entire 60-min course of the experiment. The total increase in respiration was greater than 300%. Thus neither the time course nor the magnitude of the metabolic and respiratory responses were related. Similar findings were also obtained following administration of 2,4-dinitrophenol. We conclude that these agents stimulate respiration by a mechanism other than one related to the ability to uncouple oxidative phosphorylation and cause an increase in whole-body metabolism.
D019297:2,4-Dinitrophenol; D000818:Animals; D001481:Basal Metabolism / Q000187:drug effects*; D002245:Carbon Dioxide / Q000378:metabolism / Q000502:physiology; D002415:Cats; D004140:Dinitrophenols / Q000494:pharmacology*; D010791:Phrenic Nerve / Q000502:physiology; D012119:Respiration / Q000187:drug effects*; D012980:Sodium Salicylate / Q000494:pharmacology*
D004140:Dinitrophenols; D002245:Carbon Dioxide; D019297:2,4-Dinitrophenol; D012980:Sodium Salicylate