[Effect of a single dose of hydrocortisone and adrenaline on the synthesis of nuclear proteins and DNA in the rat thymus].
Single injections of hydrocortisone and adrenaline low doses long before the rat killing induced a change in the level of thymic DNA and nuclear protein synthesis. The effect and direction of hormone activity were dependent on the day time and duration of hormone presence in the organism. Hydrocortisone in a dose of 10 mg/kg, injected at 11 o'clock, promoted thymic DNA synthesis, whereas adrenaline in a dose of 0.06 mg/kg, administered at 11 o'clock, inhibited DNA synthesis, stimulating it, when injected at 23 o'clock.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D004837:Epinephrine / Q000008:administration & dosage*; D006657:Histones / Q000096:biosynthesis*; D006854:Hydrocortisone / Q000008:administration & dosage*; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats; D013950:Thymus Gland / Q000648:ultrastructure*; D013997:Time Factors
D006657:Histones; D004247:DNA; D006854:Hydrocortisone; D004837:Epinephrine
Vliianie odnokratnogo vvedeniia gidrokortizona i adrenalina na uroven' sinteza iadernykh belkov i DNK v timuse krys.