title: Influence of peroral charcoal on pharmacokinetics and intestinal toxicity of intravenously given methotrexate.
abstract: Intestinal toxicity is an often reported side effect of methotrexate (MTX) in man. We found in rats that the large MTX amount occurring in the intestinal lumen (31.6% of dose) after intravenous injection does not contribute to the intestinal toxicity of MTX (31 mg/kg) because  adsorption of MTX to charcoal within the intestinal lumen did not alter the reduced mitotic count and the villus height induced by MTX injection. Binding of intraluminal MTX to charcoal in vivo did not markedly alter MTX pharmacokinetics in plasma.
mesh_terms: D000818:Animals; D002606:Charcoal / Q000494:pharmacology*; D007275:Injections, Intravenous; D007410:Intestinal Diseases / Q000139:chemically induced*; D007583:Jejunum / Q000187:drug effects; D007700:Kinetics; D008297:Male; D008727:Methotrexate / Q000378:metabolism* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D002606:Charcoal; D008727:Methotrexate