Ischemic change of organic acids in kidney.
Organic acids in rabbit renal tissue biopsy were analyzed by capillary column gas chromatography--mas s spectrometry. The change of these organic acids under ischemic conditions was determined over 60 min after clamping the renal artery and vein. The results showed that lactic acid, glycolic acid, 2-hydroxybutyric acid, 3-hydroxypropionic acid, 2-methyl-glyceric acid, glyceric acid and malic acid increased at 4 and 6 min after clamping, but then decreased at 15 min. Glycerol increased 2 min after clamping and then decreased. However, 3-deoxyaldonic acids of 3-deoxytetronic acid, 3-deoxy-2-C-hydroxymethyltetronic acid and 3-deoxypentonic acid decreased in the renal tissue biopsy from 2 min after clamping.
D000818:Animals; D002264:Carboxylic Acids / Q000032:analysis / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D007511:Ischemia / Q000378:metabolism*; D007668:Kidney / Q000032:analysis / Q000098:blood supply*; D008297:Male; D011817:Rabbits; D013997:Time Factors
D002264:Carboxylic Acids