[Effects of protein calorie intake on immuno- and chemotherapy].
Immuno-chemotherapeutic effect on growth of 81B mammary tumor was studied in syngeneic C3H/He mice fed diet with low (D) or normal (N) protein content. 1. 5-FU 20 mg/kg. was given intra-peritoneal daily for 3 weeks. The tumor volume ratio (T/C) was significantly reduced on day 14 in both N and D-group mice. However, all mice were dead 2 weeks after administration of 5-FU in D-group mice. 2. Immuno-potentiator OK-432 (50 KE/kg,) or Lentinan (5 mg/kg,) was given i.p. daily for 3 weeks. The 81B tumor growth was inhibited on day 14 in N-group mice. However, the tumor growth was paradoxically accelerated after administration of these agents in D-group mice. Augmentation of the natural killer cell activity was recognized in N-group mice treated with OK-432 or Lentinan, but no change was seen in D-group mice. 3. After administration of 5-FU, intra-tumoral concentration of 5-FU was higher in N-group mice than that of in D-group mice.
D000818:Animals; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D007694:Killer Cells, Natural / Q000276:immunology; D007912:Lentinan / Q000627:therapeutic use; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*; D051379:Mice; D008809:Mice, Inbred C3H; D010844:Picibanil / Q000627:therapeutic use; D011502:Protein-Energy Malnutrition / Q000150:complications
D004044:Dietary Proteins; D007912:Lentinan; D010844:Picibanil; D005472:Fluorouracil