Acute oral toxicity of butyl nitrite.
Butyl nitrite is present in consumer products subject to abuse by inhalation. When inhaled, intense peripheral vasodilation and tachycardia ensue, described by users as a 'rush'. When ingested, toxic sequelae include methemoglobinemia and hypokinetic anoxia. The median lethal oral dose to rats of this compound is, with 95% confidence, 83 +/- 3.5 mg kg-1.
D000284:Administration, Oral; D000818:Animals; D004750:Enteral Nutrition; D007928:Lethal Dose 50; D008297:Male; D009573:Nitrites / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000633:toxicity*
D009573:Nitrites; D014665:Vasodilator Agents; C024225:n-butyl nitrite