Granulocyte antigen systems and antibodies and their clinical significance.
Granulocyte alloantibodies and autoantibodies have a key role in the pathophysiology of several clinical problems. These include febrile transfusion reactions, severe pulmonary reactions to transfusion, isoimmune neonatal neutropenia, failure of effective granulocyte transfusion, autoimmune neutropenia, drug-induced neutropenia, and neutropenias secondary to many other diseases. Although many techniques are available for detecting granulocyte antibodies, the optimal in-vitro tests for predicting the antibodies' clinical effects are not established. Use of indium-111-labeled granulocytes may provide valuable information regarding the in-vivo effects of different granulocyte antibodies. Granulocyte transfusions continue to be used for a limited number of severely infected neutropenic patients who do not respond to antibiotic therapy.
D000906:Antibodies / Q000276:immunology*; D000918:Antibody Specificity; D000941:Antigens / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D001803:Blood Transfusion; D006098:Granulocytes / Q000276:immunology* / Q000637:transplantation; D006801:Humans; D007204:Indium; D009503:Neutropenia / Q000276:immunology; D011868:Radioisotopes
D000906:Antibodies; D000941:Antigens; D001323:Autoantibodies; D011868:Radioisotopes; D007204:Indium