Electrophoretic characterization and genetics of human biliverdin reductase (BLVR; EC 1.3.1.24); assignment of BLVR to the p14 leads to cen region of human chromosome 7 in mouse-human somatic cell hybrids.
A simple chromogenic staining procedure is described for the specific identification of biliverdin reductase (BLVR) after gel electrophoresis. Using this procedure a gene for BLVR was assigned to the p14 leads to cen region of human chromosome 7 in human-mouse somatic cell hybrids. Incidentally, the study indicated that the NADH-as well as the NADPH-dependent BLVR activities are due to one and the same enzyme and that, most probably, only one gene in the human genome codes for BLVR and the BLVR is a monomer in its functional configuration.
D000818:Animals; D002459:Cell Fusion; D002906:Chromosomes, Human, 6-12 and X; D002999:Clone Cells / Q000201:enzymology; D004912:Erythrocytes / Q000201:enzymology; D005347:Fibroblasts / Q000201:enzymology; D005796:Genes; D006801:Humans; D006822:Hybrid Cells / Q000201:enzymology*; D007962:Leukocytes / Q000201:enzymology; D051379:Mice; D010088:Oxidoreductases / Q000235:genetics*; D044925:Oxidoreductases Acting on CH-CH Group Donors
D010088:Oxidoreductases; D044925:Oxidoreductases Acting on CH-CH Group Donors; C019789:biliverdin reductase