[Activity of microsomal enzymes and lipid peroxidation in the liver in galactosamine injury].
Galactosamine injury of rat liver brings about induction of microsomal oxidation enzymes after 24 hours. Such a conclusion may be arrived at on the basis of an analysis of variation in the activity of cytochrome P-450, cytochrome b5, and NADH ferricyanide reductase while comparing normal and galactosamine-treated rats. In vitro galactosamine leads to activation of enzymatic lipid peroxidation. This circumstance may underlie hepatotoxicity of the compound in question. The monitoring coagulation method has revealed a marked hemorrhagic syndrome after galactosamine administration. Upset synthesis of export liver protein is assumed.
D000818:Animals; D001462:Barbital / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005688:Galactosamine / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000187:drug effects*; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats
D008054:Lipid Peroxides; D001462:Barbital; D005688:Galactosamine; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D009247:NADH, NADPH Oxidoreductases; C014227:ferricyanide reductase
Aktivnost' mikrosomal'nykh fermentov i perekisnoe okislenie lipidov pecheni pri ee porazhenii galaktozaminom.