Control of growth in the rat thyroid--an example of specific desensitization to trophic hormone stimulation.
Rat thyroid follicular cells desensitized to the mitogenic action of TSH by prolonged stimulation retain the capacity to respond to the mitogenic stimulus of wounding. The implications for thyroid growth control and neoplasia are discussed.
D000818:Animals; D008297:Male; D008938:Mitosis; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000187:drug effects / Q000254:growth & development* / Q000293:injuries; D013972:Thyrotropin / Q000494:pharmacology*
D013972:Thyrotropin