UV-absorbing and other sun-protecting substances: genotoxicity of 2-ethylhexyl P-methoxycinnamate.
The mutagenicity of 2-ethylhexyl p-methoxycinnamate was demonstrated when 25 sunscreen ingredients were tested in the Salmonella/microsome assay. This substance also increased the frequency of sex-linked recessive lethals in Drosophila melanogaster. A trace contaminant may be implicated because many samples were obtained from several sources and the results were batch-related.
D000818:Animals; D001711:Biotransformation; D002934:Cinnamates / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000235:genetics; D005804:Genes, Lethal / Q000187:drug effects; D005808:Genes, Recessive / Q000187:drug effects; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship; D013473:Sunscreening Agents / Q000494:pharmacology*; D014466:Ultraviolet Rays
D002934:Cinnamates; D009153:Mutagens; D013473:Sunscreening Agents; C118580:octylmethoxycinnamate