title: Site of airway obstruction after rapid saline infusion in healthy subjects.
abstract: Static and dynamic lung volumes, flow-volume curve in air and after He-O2 were carried out in 5 normal subjects baseline, immediately after rapid infusion of 2 litres of normal saline, and then 15, 30 and 60 min after. At the end of the infusion, a marked reduction of delta MEF50, FVC, FEV1, MEF50, MEF25 and an increase of Viso V and CV/VC were observed in all the subjects. The poor response to He-O2 suggests a predominant increase of small airway resistance after rapid infusion. In the recovery phase, He-O2 tests promptly returned to control values, while an increased CV/VC was detectable until 30 min after the infusion.
mesh_terms: D000328:Adult; D000402:Airway Obstruction / Q000139:chemically induced / Q000473:pathology*; D001158:Arteries; D003011:Closing Volume; D005540:Forced Expiratory Flow Rates; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008448:Maximal Expiratory Flow Rate; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D012965:Sodium Chloride / Q000008:administration & dosage*; D014797:Vital Capacity
chemical_list: D012965:Sodium Chloride; D010100:Oxygen