Diffuse alveolar damage syndrome associated with amiodarone therapy.
Amiodarone is an effective antiarrhythmic that has been used in Europe for over a decade and has been available for investigational use in North America for a shorter time. It has several well recognized side effects. Recent reports have related pulmonary disorders to the use of this drug; fibrosing alveolitis has been found by lung biopsy. Amiodarone's toxicity to the lung does not appear to be dose-related. Besides cessation of amiodarone administration, management of this complication includes steroid therapy. A case is described of nonspecific diffuse alveolar damage syndrome in a patient who had received amiodarone.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D001572:Benzofurans / Q000009:adverse effects*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D011650:Pulmonary Alveoli / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography; D012129:Respiratory Function Tests; D013577:Syndrome
D000305:Adrenal Cortex Hormones; D001572:Benzofurans; D000638:Amiodarone