title: Antibiotic sensitivities of Neisseria gonorrhoeae in the Far East: comparison of plasmid species in isolates from six countries.
abstract: In vitro susceptibility testing of 36 strains of Neisseria gonorrhoeae isolated in the Far East in 1979 and 1980 demonstrated that 27 penicillinase-producing (PPNG) isolates and nine non-penicillinase-producing (non-PPNG) isolates were susceptible to chloramphenicol, thiamphenicol, spectinomycin, trimethoprim-sulfamethoxazole, cefoperazone, moxalactam, cefotaxime, and ceftriaxone. In comparison, 50% of the strains had MICs of tetracycline of greater than 2 micrograms/ml, and 75% had MICs, of streptomycin of greater than 128 micrograms/ml. Eighty-two per cent of PPNG and 100% of non-PPNG isolates examined had MICs of kanamycin of greater than 32 micrograms/ml. None of the nine non-PPNG strains had MICs of ampicillin and penicillin of greater than 1 microgram/ml. A 4.4-megadalton plasmid, previously associated with beta-lactamase production, was found in all 27 PPNG isolates examined; 93% of PPNG and 22% of non-PPNG isolates contained a 24-megadalton plasmid previously associated with transfer of the 4.4-megadalton plasmid.
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004247:DNA / Q000235:genetics; D005202:Asia, Eastern; D006069:Gonorrhea / Q000382:microbiology; D006801:Humans; D066298:In Vitro Techniques; D007612:Kanamycin / Q000494:pharmacology; D008297:Male; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000302:isolation & purification; D010405:Penicillinase / Q000378:metabolism; D010406:Penicillins / Q000494:pharmacology; D010957:Plasmids / Q000187:drug effects*; D013752:Tetracycline / Q000494:pharmacology; D001618:beta-Lactamases / Q000096:biosynthesis
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D007612:Kanamycin; D000667:Ampicillin; D004247:DNA; D010405:Penicillinase; D001618:beta-Lactamases; D013752:Tetracycline