Involvement of central noradrenergic system in thyrotropin-releasing hormone-induced behavioral excitement in 6-OHDOPA-treated, infant rats.
A subcutaneous (s.c.) injection of thyrotropin-releasing hormone (TRH) 20 mg/kg, produced body shake and struggle, consequently induced an increase of count in ANIMEX activity meter in 7-day-old rats pretreated with 6-hydroxydopa (6-OHDOPA), 75 mg/kg, on days 0, 2 and 4. TRH-induced behavioral excitement was markedly attenuated in the infant animals which were injected desmethylimipramine, 5 mg/kg, 30 min before 6-OHDOPA on days 0, 2 and 4. It is suggested that central catecholaminergic, in particular, noradrenergic system is involved in TRH-induced body shake and struggle in 6-OHDOPA-treated, infant rats.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003891:Desipramine / Q000494:pharmacology; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology; D005260:Female; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D013997:Time Factors
C001388:6-hydroxydopa; D013973:Thyrotropin-Releasing Hormone; D004295:Dihydroxyphenylalanine; D003891:Desipramine; D004298:Dopamine; D009638:Norepinephrine