Phenthoate-induced changes in the profiles of acetylcholinesterase and acetylcholine in the brain of Anabas testudineus (Bloch): acute and delayed effect.
A concomitant decrease in acetylcholinesterase (AChE) activity and increase in acetylcholine (ACh) concentration was observed in the brain of Anabas testudineus (Bloch) during a 48-h phenthoate treatment. On return to phenthoate-free fresh water, the decline in enzyme activity and rise in ACh concentration was found to persist for up to 20 days following exposure. Normal values for brain AChE activity and ACh concentration were restored only after 60 days following transfer to phenthoate-free fresh water. It is concluded that inhibition of AChE results in ACh accumulation which, in turn, initiates a faster rate of recovery of the enzyme in fish exposed to the highest concentration of phenthoate.
D000109:Acetylcholine / Q000378:metabolism*; D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D005399:Fishes / Q000378:metabolism*; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D014874:Water Pollutants, Chemical
D009946:Organothiophosphorus Compounds; D014874:Water Pollutants, Chemical; D000110:Acetylcholinesterase; C008838:phenthoate; D000109:Acetylcholine