Influence of a non-synthetic diet with a high fat content on the local occurrence of colonic carcinomas induced by N-nitroso-acetoxymethylmethylamine (AMMN) in Sprague-Dawley Rats.
Low doses (0.1 mg/animal administered fortnightly for 48 weeks) of the local carcinogen N-nitrosoacetoxymethylmethylamine (acetoxymethylmethylnitrosamine, AMMN) were administered intrarectally to Sprague-Dawley rats fed a standard diet (Altromin pellets) and resulted in a 22% incidence of colonic cancer. When the carcinogen was administered to rats kept on a nonsynthetic diet with a high fat content for their entire life-time, the colonic cancer risk was identical. The results demonstrate that an unbalanced high-fat diet need not necessarily increase the colonic cancer risk caused by a chemical carcinogen.
D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced*; D004041:Dietary Fats / Q000008:administration & dosage*; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains
D004041:Dietary Fats; C014659:methyl(acetoxymethyl)nitrosamine; D004128:Dimethylnitrosamine