[Action of chemical and physical mutagenic factors on the tetracycline producer Streptomyces aureofaciens].
The mutagenic effects of N-nitrozomethylbiuret (N-NMB), N-nitrozomethylurea (N-NMU), N-nitrozodimethylurea (N-NDMU), ethylene imine and UV light on Str. aureofacients producing tetracycline was studied comparatively. It was shown that N-NMU and N-NMB had a higher toxicity and mutagenic activity as compared to N-NDMU. The toxicity levels of N-NMU and N-NMB were similar. Still, by the number of the morphological mutations induced by them N-NMU was more effective.
D014644:Genetic Variation / Q000187:drug effects / Q000528:radiation effects; D009153:Mutagens / Q000494:pharmacology*; D013171:Spores, Bacterial / Q000187:drug effects / Q000528:radiation effects; D013304:Streptomyces aureofaciens / Q000187:drug effects* / Q000528:radiation effects; D013752:Tetracycline / Q000096:biosynthesis*; D014466:Ultraviolet Rays
D009153:Mutagens; D013752:Tetracycline
Izuchenie deĭstviia khimicheskikh i fizicheskikh mutagennykh faktorov na produtsent tetratsiklina Streptomyces aureofaciens.