Quantitation of tear lysozyme levels in dry-eye disorders.
A simple, rapid, reproducible method of quantifying tear lysozyme levels with a dual-channel spectrophotometer was used to compare normal subjects and those with dry-eye syndrome. The method was sensitive (80%) and specific (85%) and had a predictive value of a positive result of 83%. One patient with clinical manifestations of dry-eye syndrome and paradoxically elevated levels of tear lysozyme was found to have underlying sarcoidosis.
D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000201:enzymology*; D009113:Muramidase / Q000378:metabolism*; D012507:Sarcoidosis / Q000201:enzymology; D012859:Sjogren's Syndrome / Q000201:enzymology; D013577:Syndrome; D013666:Tears / Q000201:enzymology*
D009113:Muramidase