[Effect of acetylcholine on the lysosome function of liver and kidneys in severe mechanical trauma].
The functions of rat hepatic and renal lysosomes were explored during severe mechanical trauma caused by soft tissue compression in the presence of acetylcholinesterase induction by multiple acetylcholine administration. The increase of the trauma severity entailed the accumulation of non-hydrolyzed acetylcholine, thereby producing an injurious action on lysosomal membranes. Varying intensity of the changes in the activity of lysosomal hydrolases under study is likely to be related to the structural features of hepatic and renal lysosomes.
D000109:Acetylcholine / Q000494:pharmacology*; D000110:Acetylcholinesterase / Q000096:biosynthesis; D000818:Animals; D003444:Crush Syndrome / Q000201:enzymology / Q000209:etiology*; D004790:Enzyme Induction / Q000187:drug effects; D006867:Hydrolases / Q000096:biosynthesis; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012774:Shock, Traumatic / Q000209:etiology*; D013997:Time Factors
D006867:Hydrolases; D000110:Acetylcholinesterase; D000109:Acetylcholine
Vliianie atsetilkholina na funktsional'noe sostoianie lizosom pecheni i pochek krys pri tiazheloĭ mekhanicheskoĭ travme.