Immunological aspects of Behçet's and Vogt-Koyanagi-Harada's diseases.
Immunogenetic studies showed that Behçet's disease has a primary association with HLA-B antigen (HLA-BW51) and the same association throughout the world, whereas, Vogt-Koyanagi-Harada's disease (VKH) is primarily associated with supertypic HLA-DR antigen (MT3), an HLA-D-linked B cell alloantigen in Japanese. Immunological investigation showed that the serum levels of gamma-interferon (IFN-gamma) were significantly increased in both Behçet's disease and VKH, IFN-gamma showed a significant decrease in the ocular exacerbation stage in Behçet's disease. The highest IFN titre was observed 1 to 2 months after the onset of the disease in VKH.
D001528:Behcet Syndrome / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D015235:HLA-B Antigens; D059949:HLA-B51 Antigen; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007371:Interferon-gamma / Q000097:blood / Q000276:immunology; D008297:Male; D013997:Time Factors; D014605:Uveitis / Q000276:immunology*; D014607:Uveomeningoencephalitic Syndrome / Q000276:immunology*
D006680:HLA Antigens; D015235:HLA-B Antigens; D059949:HLA-B51 Antigen; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D007371:Interferon-gamma