Effects of saturated, monounsaturated, and omega-6 polyunsaturated fatty acids on plasma lipids, lipoproteins, and apoproteins in humans.
The effects of dietary fats on plasma cholesterol, serum lipoproteins, and apoproteins (Apo), A-1, B, and CIII were studied. Twelve men consumed three different cholesterol-free formula diets in which polyunsaturated and saturated fats were partially substituted (20% of calories) for monoenoic fats with a constant of 40% of calories from fat. Total cholesterol and low-density lipoprotein cholesterol dropped from base-line values of 166 and 103 to 133 and 81 mg/dl (sat), 127 and 71 mg/dl (mono), and 123 and 65 mg/dl (poly), respectively. High-density lipoprotein cholesterol changed very little from base-line values of 46 to 40 mg/dl (sat), 45 mg/dl (poly), and 43 mg/dl (mono). The plasma concentrations of ApoB declined from base-line values of 80.3 mg/dl to 54.6 mg (mono), 51.8 mg (poly), and 59.6 mg (sat) while Apo CIII and Apo AI did not show any changes. This study demonstrates that: 1) changes in dietary fat affect serum lipids, lipoproteins, and apoproteins even when consumed on a cholesterol-free diet, and 2) omega-6 polyunsaturated fat lowers low-density lipoprotein cholesterol, total cholesterol, and ApoB to a greater extent than monounsaturated or saturated fat, 3) consumption of a cholesterol-free formula diet results in significant decreases in the concentrations of total and low-density lipoprotein cholesterol in plasma when compared to values obtained on a mixed food home diet containing approximately 300 mg cholesterol/day.
D000328:Adult; D001059:Apoproteins / Q000097:blood*; D001835:Body Weight; D002784:Cholesterol / Q000097:blood*; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004041:Dietary Fats / Q000494:pharmacology*; D002149:Energy Intake; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D014280:Triglycerides / Q000097:blood
D001059:Apoproteins; D002791:Cholesterol, Dietary; D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol