Autosomal dominant iridogoniodysgenesis: glaucoma management.
In a family of 55 people in seven generations 28 were known to be affected with autosomal dominant iridogoniodysgenesis. Their glaucoma was characterized by early onset of high intraocular pressures, lability of the pressure both with and without medical treatment, poor response to such treatment and resistance of the optic nerve head to damage even into early middle age. Among the surgical procedures undertaken, goniotomy was not successful but, oddly, iridencleisis was. All indications were that surgery could be delayed into adult life.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005799:Genes, Dominant; D005901:Glaucoma / Q000235:genetics / Q000628:therapy*; D006801:Humans; D007223:Infant; D007429:Intraocular Pressure; D007498:Iris / Q000002:abnormalities*; D008875:Middle Aged; D010375:Pedigree