Bolus intravenous nitroglycerin for ST-segment depression not associated with increased myocardial oxygen demand.
Ischaemic ST-segment changes may occur in patients with coronary artery disease when myocardial oxygen consumption is increased as a result of hypertension, tachycardia or increased contractility. Ischaemia can also occur as the result of decreased coronary perfusion pressure caused by hypotension or coronary artery spasm. We report ST-segment depression in the absence of hypertension, tachycardia or hypotension. The response to bolus intravenous nitroglycerin suggested coronary artery spasm as the cause.
D000328:Adult; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000503:physiopathology; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D005996:Nitroglycerin / Q000627:therapeutic use*; D010101:Oxygen Consumption / Q000187:drug effects*
D005996:Nitroglycerin