[Estradiol receptors in the rat uterus under long-term hormone administration at different doses].
Multiple administration of estrogens in doses of 1 and 10 micrograms reduces specific binding of 3H-estradiol by subcellular fractions of rat uterus tissues. The cytoreceptor apparatus of the uterus of androgen-sterile rats is marked by the decreased response to a prolonged (7-8 days) hormone administration as compared to responses seen in normal and ovariectomized animals. The depletion of estrogen receptors is not linked with a rise of the endogenous steroid level in blood plasma and cytosol from uterine tissues.
D000818:Animals; D002369:Castration; D003600:Cytosol / Q000032:analysis / Q000187:drug effects; D004958:Estradiol / Q000008:administration & dosage* / Q000032:analysis; D005260:Female; D051381:Rats; D011959:Receptors, Estradiol; D011960:Receptors, Estrogen / Q000032:analysis / Q000187:drug effects*; D013997:Time Factors; D014599:Uterus / Q000032:analysis / Q000187:drug effects*
D011959:Receptors, Estradiol; D011960:Receptors, Estrogen; D004958:Estradiol
Retseptory éstradiola v matke krys pri dlitel'nom vvedenii gormona v razlichnykh dozakh.