title: Pseudomonas. Clinical problems related to virulence factors and development of resistance.
abstract: Pseudomonas aeruginosa has emerged into the limelight mainly as a result of compromised host problems and the development of resistance leading to serious treatment difficulties. The organism possesses virulence factor that produce an effect in certain clinical situations. Changes in local anatomy, often with the presence of foreign bodies, are important (bladder and intravenous catheters, tracheostomy, burns, wounds, and injuries). Deficiencies in immune defense, particularly granulocytopenia, are almost a prerequisite for development of Pseudomonas septicemia and meningitis. The toxic factors of Pseudomonas organisms in combination with a disturbed defense mechanism produce characteristic necrotic skin lesions. A mucoid form of P aeruginosa is a characteristic feature of cystic fibrosis. Resistance of P aeruginosa to antibiotics is very definitely associated with overuse of broad-spectrum antibiotics in hospitals. New and more effective antibiotics may be needed.
mesh_terms: D036002:ADP Ribose Transferases; D001427:Bacterial Toxins; D004352:Drug Resistance, Microbial; D005098:Exotoxins / Q000096:biosynthesis; D006801:Humans; D010447:Peptide Hydrolases / Q000096:biosynthesis; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000378:metabolism / Q000472:pathogenicity; D014774:Virulence; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A
chemical_list: D036002:ADP Ribose Transferases; D001427:Bacterial Toxins; D005098:Exotoxins; D010447:Peptide Hydrolases; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A