Promutagen activation in partially hepatectomized mice.
Mutagenic activity of aflatoxin B1 (AFB1) was followed in the Ames Salmonella/microsome test using liver S-9 from control and partially hepatectomized (PH) mice. The S-9 preparations from the PH mice were capable of inducing significantly greater AFB1 mutagenic activity to strain TA100 than S-9 preparations from either unoperated control, sham-operated control, or Aroclor 1254-induced mice. Increased activity was observed with S-9 preparations made at both 42 h and 148 h following PH.
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000378:metabolism / Q000633:toxicity; D000818:Animals; D001711:Biotransformation; D006498:Hepatectomy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000235:genetics; D013347:Subcellular Fractions / Q000378:metabolism
D000348:Aflatoxins; D009153:Mutagens; D016604:Aflatoxin B1