Comparative studies on the distribution of gold, copper and zinc in the livers and kidneys of rats and hamsters after treatment with sodium [195Au]-aurothiomalate.
The distribution of gold, copper and zinc in the livers and kidneys of female rats and hamsters was determined after intraperitoneal injection of sodium [195Au]-aurothiomalate. After five doses of sodium [195Au]-aurothiomalate (1 mg Au(I) per kg body weight), the hepatic and renal concentrations of Au were greater in rats than in hamsters. In the former species, treatment with the Au(I)-compound led to an increase in the Cu-concentration of the kidney and to the synthesis of a (Cu, Au)-metallothionein. In either species binding of Au to the hepatic metallothionein was insignificant. The renal (Cu, Au)-metallothionein from the sodium [195Au]-aurothiomalate-treated rat appeared to be extremely heterogeneous and was resolved into at least four components on ion exchange chromatography.
D000818:Animals; D003300:Copper / Q000378:metabolism*; D005260:Female; D006046:Gold / Q000378:metabolism*; D006050:Gold Radioisotopes; D006052:Gold Sodium Thiomalate / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008970:Molecular Weight; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D015032:Zinc / Q000378:metabolism*
D006050:Gold Radioisotopes; D006052:Gold Sodium Thiomalate; D006046:Gold; D003300:Copper; D015032:Zinc