alpha-Particle track autoradiography for localization of a 211At-astatinated drug.
A potential endoradiotherapeutic drug, 6-211At-astato-2-methyl-1,4-naphthoquinol bis (diphosphate salt), incorporating the alpha-emitting radio-halogen astatine-211 of half-life 7.2 h, is shown to be valuable for localization studies by means of alpha-particle track autoradiography in malignant and normal cells and tissues in the mouse with transplanted adenocarcinoma of the rectum.
D000230:Adenocarcinoma / Q000378:metabolism*; D000512:Alpha Particles; D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism; D001246:Astatine / Q000378:metabolism*; D001345:Autoradiography; D003106:Colon / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism; D012004:Rectal Neoplasms / Q000378:metabolism*; D013154:Spleen / Q000378:metabolism; D013347:Subcellular Fractions / Q000378:metabolism; D014812:Vitamin K / Q000031:analogs & derivatives* / Q000378:metabolism; D024483:Vitamin K 3 / Q000031:analogs & derivatives*
D000970:Antineoplastic Agents; D014812:Vitamin K; D024483:Vitamin K 3; C033669:astato-2-methyl-1,4-naphthoquinol diphosphate; D001246:Astatine