Chlorprothixene and chlorprothixene-sulfoxide in body fluids from a case of drug overdose.
A case of fatal drug overdose involving chlorprothixene is presented. Chlorprothixene and chlorprothixene sulfoxide (CPT-SO) metabolite concentrations (mg/L) in body fluids as determined by spectrophotofluorometry were: blood, 0.10 and 0.60; bile, 3.9 and 7.0; urine, 0.4 and 3.4; and stomach contents, 340 mg and 25 mg total, respectively. Qualitative identification of chlorprothixene and CPT-SO was by thin layer and gas liquid chromatography and spectrophotofluorometry following alkaline permanganate oxidation.
D000328:Adult; D001646:Bile / Q000032:analysis; D002749:Chlorprothixene / Q000031:analogs & derivatives* / Q000032:analysis* / Q000506:poisoning; D002845:Chromatography / Q000379:methods; D006801:Humans; D008297:Male; D013057:Spectrum Analysis / Q000379:methods
C037465:chlorprothixene sulfoxide; D002749:Chlorprothixene