Plasma exchange and moderate dose of cytostatics in advanced macro(cryo)globulinemia. A report on three cases.
Three cases of advanced macroglobulinemia (two with severe cryoglobulinemia) have been treated for 6, 4 and 3 years, respectively, with regular plasma exchange and, during the last two years, also with short courses of cytostatics. The plasma exchange regimen has given the patients a marked relief from hyperviscosity symptoms and may have contributed to the improved peripheral blood values and lowered P-IgM levels. Addition of cytostatics, however, was necessary to obtain a lasting remission.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003449:Cryoglobulinemia / Q000628:therapy*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D008875:Middle Aged; D010265:Paraproteinemias / Q000628:therapy*; D010951:Plasma Exchange; D011241:Prednisone / Q000627:therapeutic use; D008258:Waldenstrom Macroglobulinemia / Q000628:therapy*
D000970:Antineoplastic Agents; D003520:Cyclophosphamide; D008558:Melphalan; D011241:Prednisone