Cardiac catabolic factors: the degradation of heart valve intercellular matrix.
Cultures of porcine heart valves and aorta secrete a factor that stimulates the degradation of cartilage matrix in a fashion similar to that displayed by synovial catabolin. The heart valve factor also induces the release of chondroitin sulfate and hydroxyproline from isolated heart valve cultures. The present observations support the hypothesis that tissues producing catabolic factors (catabolins) may well be responsive to them and that these messengers may play a role in the cellular regulation of the degradation of intercellular macromolecules.
D000818:Animals; D001011:Aorta / Q000378:metabolism; D002356:Cartilage / Q000378:metabolism; D002807:Chondroitin / Q000031:analogs & derivatives*; D002809:Chondroitin Sulfates / Q000378:metabolism*; D046508:Culture Techniques; D006351:Heart Valves / Q000378:metabolism*; D006909:Hydroxyproline / Q000378:metabolism*; D007375:Interleukin-1; D053583:Interleukin-1beta; D010210:Papillary Muscles / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D013552:Swine
D007375:Interleukin-1; D053583:Interleukin-1beta; D011506:Proteins; D002807:Chondroitin; D002809:Chondroitin Sulfates; D006909:Hydroxyproline