The multiple molecular forms of acetylcholinesterase in "motor end-plate disease" in the mouse (medJ and med allelic forms): sensitivity of the 10 S form to partial or total loss of muscle activity.
Motor end-plate disease in the mouse is a mutation, lethal at the time of weaning. Two alleles exist, med and medJ, with medJ/medJ surviving slightly longer. The multiple molecular forms of acetylcholinesterase show an abnormal developmental pattern during the course of the disease. A decrease in the 10 S AChE proportion to total AChE activity is the major change in gastrocnemius muscle. Similar AChE changes occur after total short-term denervation, tenotomy, and in other genetic diseases. Thus it appears that AChE is modified in med/med muscle as the result of a partial or total loss of muscle activity.
D000110:Acetylcholinesterase / Q000032:analysis* / Q000235:genetics; D000483:Alleles; D000818:Animals; D000831:Animals, Newborn; D006579:Heterozygote; D006720:Homozygote; D051379:Mice; D008810:Mice, Inbred C57BL; D009045:Motor Endplate; D009132:Muscles / Q000201:enzymology; D009154:Mutation; D009468:Neuromuscular Diseases / Q000201:enzymology* / Q000235:genetics
D000110:Acetylcholinesterase