omega-Aminoalkyl beta-glycosides of N-acetylmuramyl-L-alanyl-D-isoglutamine, and their conjugates with meningococcal group C polysaccharide.
The 6-aminohexyl beta-glycoside of N-acetylmuramyl-L-alanyl-D-isoglutamine and its spacer-arm-linked analog (3.8 nm) were synthesized from 2-methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-alpha-D-glucopyrano)-[2,1-d]-2- oxazoline, and coupled with meningococcal group C polysaccharide in attempts to enhance the immunogenicity of the polysaccharide antigen.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives*; D000617:Aminoglycosides / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D013329:Structure-Activity Relationship
D000617:Aminoglycosides; D007202:Indicators and Reagents; D011135:Polysaccharides, Bacterial; C037676:meningococcal group C polysaccharide; D000119:Acetylmuramyl-Alanyl-Isoglutamine