title: The effects of chemotherapy on bony metastases as measured by quantitative skeletal imaging.
abstract: The effect of chemotherapy on bony metastases from adenocarcinoma of the colon was investigated by quantitative skeletal imaging over a two-month interval. The quantitative skeletal imaging results correlated with conventional blood chemistry results over this time period. While chemical assay techniques furnish an average value of lesion response, the quantitative bone scan represents a method for individual lesion analysis. This methodology has the potential to provide a better understanding of metastatic bone disease therapy.
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary*; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D003110:Colonic Neoplasms / Q000473:pathology; D004164:Diphosphonates; D005472:Fluorouracil / Q000627:therapeutic use; D005857:Germanium / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D011877:Radionuclide Imaging; D013141:Spiro Compounds / Q000627:therapeutic use; D013667:Technetium; D017556:Technetium Compounds; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D004164:Diphosphonates; D009942:Organometallic Compounds; D013141:Spiro Compounds; D017556:Technetium Compounds; D005857:Germanium; C026818:spirogermanium; D013667:Technetium; C029045:technetium Tc 99m diphosphonate; D005472:Fluorouracil