[Energetic metabolism of the placenta and vascular blood flow as criteria for the choice of drugs in risk pregnancy--results of our investigations].
Object of this paper was to estimate the vascular resistances of the placenta and the lactate/pyruvate-quotient influenced by 8 and 40 mu/min orciprenaline and 320 micrograms/min papaverine. 38 placentas were tested in extraorganic circulation. The content of lactic acid and pyruvic acid was determined in the perfusion solution flowing out of the umbilical vein. Pressure was registered with cymograph. Infusion of 8 micrograms/min orciprenaline diminishes the lactate/pyruvate-quotient and the vascular resistances. 40 micrograms/min orciprenaline causes spasm of placental vessels in the terminal phase of examination. In this group the processes of oxygenation were limited by the oxygen content in the perfusion solution. Papaverine turned the metabolism of the placenta to an anaerob way and the antispasmodic effect was shortlasting.--Therefore the drug effect results out of a metabolic and a spasmolytic component. In risk pregnancy there has to be considered in addition to the spasmolytic the metabolic effects, too.
D005260:Female; D006801:Humans; D009921:Metaproterenol / Q000494:pharmacology*; D010208:Papaverine / Q000494:pharmacology*; D010920:Placenta / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D011312:Pressure; D012306:Risk; D014655:Vascular Resistance / Q000187:drug effects
D009921:Metaproterenol; D010208:Papaverine
Der energetische Metabolismus der Plazenta und der Gefässdurchfluss als Kriterien für die Wahl der Arzneimittel bei der Risikoschwangerschaft--Ergebnisse eigener Untersuchungen.