Primary varicose veins and HLA.
138 patients with primary varices of the lower extremities were typed in two independent studies for 41 HLA antigens A, B, C, and their frequencies were compared to those in controls. In both studies, the patients showed higher frequency of HLA-B7 (36.2 vs. 23.4%, relative risk 1.86, p = 0.0013) and lower frequencies of HLA-Aw19 (9.4 vs. 25.0%, relative risk 0.312, p = 0.00006), Cw5 (0.7 vs. 9.8%, relative risk 0.067, p = 0.0001) and Cw6 (7.3 vs. 27.0%, relative risk 0.212, p = 0.00003). These differences were most pronounced in patients whose fathers also suffered from primary varices. No relationship was found between HLA antigens and the sex of the patients or the age at the onset of varices.
D000328:Adult; D004198:Disease Susceptibility; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012744:Sex Ratio; D014648:Varicose Veins / Q000235:genetics* / Q000276:immunology
D006680:HLA Antigens