Disseminate sporotrichosis of skin and bone cured with 5-fluorocytosine: Photosensitivity as a complication.
Disseminate cutaneous and osseous sporotrichosis is reported in a patient who failed to respond to 6 months of iodide therapy. Although the patient showed improvement on a 2-month course of amphotericin B, he experienced a fulminant relapse 12 days after the amphotericin B was stopped. Cure was achieved after 6 months of 5-fluorocytosine (8 gm/day) in conjunction with amphotericin B (total, 4.8 gm). The fluorocytosine was continued for an entire year. Two years after all treatment was discontinued the patient remained in good health. The only complication was a marked photosensitivity associated with the 5-fluorocytosine therapy. This is the second case of such photosensitivity in the literature.
D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage; D001847:Bone Diseases / Q000188:drug therapy*; D003596:Cytosine / Q000031:analogs & derivatives*; D004359:Drug Therapy, Combination; D005437:Flucytosine / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D012867:Skin / Q000473:pathology; D012874:Skin Diseases, Infectious / Q000188:drug therapy*; D013174:Sporotrichosis / Q000188:drug therapy* / Q000473:pathology
D000666:Amphotericin B; D003596:Cytosine; D005437:Flucytosine