title: Necrotizing fasciitis: the Howard University Hospital experience.
abstract: All surgical cases from 1965 to 1980 and autopsy cases from 1974 to 1980 diagnosed at Howard University Hospital as necrotizing fasciitis (NF) were reviewed. Eight patient fulfilled the criteria for NF, which included (1) fascial necrosis, (2) spreading cellulitis with undermining of fascial planes, and (3) systemic toxicity as evidenced by altered mental state and hyperthermia. Bacteroides fragilis was commonly found in our most recent cases. Poor prognostic signs included (1) documented bacteremia, (2) preoperative hypotension (systolic blood pressure lower than 80 mmHg), and (3) hypocalcemia (serum calcium less than 7.0 mg/dL). Therapy consisted of wide debridement with systemic antibiotics and delayed skin grafting when needed.
mesh_terms: D000368:Aged; D003646:Debridement; D005208:Fasciitis / Q000209:etiology* / Q000601:surgery; D005260:Female; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000209:etiology; D013530:Surgical Wound Infection / Q000209:etiology*; D013543:Sweat Gland Diseases / Q000601:surgery