[Effect of alpha-tocopherol on the hydroxylating system and lipid peroxidation in membranes of endoplasmic reticulum from ischemic rat liver].
If 60 min long ischemia of a liver tissue lobe occurred after feeding of rats with oil emulsion of alpha-tocopherol at a dose of 50 mg/kg within 12 hrs during 2 days, the "ischemic" decrease in metabolism of amidopyrine and aniline, in content of cytochrome P-450 and activity of initial and middle steps of NADPH-dependent redox chain as well as intensification of ascorbate-dependent peroxidation of membrane lipids were prevented in endoplasmic reticulum of hepatocytes. The protective effect of alpha-tocopherol on these xenobiotics metabolism is apparently related to an increase in catalytic activity of cytochrome P-450, to the enzyme antioxidant and membrane-stabilizing properties.
D000818:Animals; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism*; D007511:Ischemia / Q000378:metabolism*; D007700:Kinetics; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology*
D008054:Lipid Peroxides; D008563:Membrane Lipids; D014810:Vitamin E
Vliianie alpha-tokoferola na gidroksiliruiushchuiu sistemu i perekisnoe okislenie lipidov membran éndoplazmaticheskogo retikuluma ishemizirovannoĭ pecheni krys.