Differential susceptibility of chlamydiae to exogenous fibroblast interferon.
Mouse fibroblasts (L cells) were incubated for 5 h with 1,000 U of murine fibroblast interferon (MuIFN alpha+ beta) per ml and then were infected with either Chlamydia trachomatis (LGV 440), C. psittaci (6BC), or C. psittaci (Cal 10). Intracellular development of C. trachomatis was reduced 90% in interferon-treated cells 24 h after infection when compared with controls, whereas C. psittaci growth was not affected in interferon-treated cells.
D000818:Animals; D002692:Chlamydia trachomatis / Q000254:growth & development*; D002691:Chlamydophila psittaci / Q000254:growth & development*; D007370:Interferon Type I / Q000494:pharmacology*; D007739:L Cells; D051379:Mice; D013045:Species Specificity
D007370:Interferon Type I