title: The retention of 14C-DTPA in human volunteers after inhalation or intravenous injection.
abstract: This study in human volunteers was designed to compare the retention of diethylenetriaminepentaacetic acid (DTPA) in the body after intravenous (i.v.) injection with that following inhalation by using a 14C labelled tracer. After i.v. injection retention in the blood could be described by three exponential components with half-times of about 1.4 min (approximately 60%) 14.3 min (approximately 20%) and 95 min (approximately 20%). By 24 hr more than 99% of the 14C-DTPA had been excreted in the urine and less than 0.5% remained in the plasma. After inhalation of 14C-DTPA retention in the lungs could be represented by a single component with a half time of about 75 min. As a consequence the length of time that a therapeutically useful amount of DTPA is retained in the body is approximately twice that following intravenous injection.
mesh_terms: D000328:Adult; D000336:Aerosols; D002250:Carbon Radioisotopes; D003666:Decontamination; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D004369:Pentetic Acid / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D000336:Aerosols; D002250:Carbon Radioisotopes; D004369:Pentetic Acid