Predominantly vascular amyloid deposition in the kidney in patients with minimal or no proteinuria.
A series of nine patients with secondary (AA type) renal amyloidosis with little or no proteinuria is reported. Renal failure was the presenting sign of renal disease in seven patients. Renal biopsy revealed a predominantly vascular deposition of amyloid in all patients. Three patients had no glomerular amyloid deposits. This pattern of amyloid deposition was found in 12.5% of our renal biopsies from patient with amyloidosis. No significant clinical differences, other than the lack of proteinuria, were noted between these patients and patients with the usual pattern of amyloid deposition.
D000328:Adult; D000368:Aged; D000682:Amyloid / Q000378:metabolism*; D000686:Amyloidosis / Q000378:metabolism / Q000473:pathology*; D001808:Blood Vessels / Q000378:metabolism; D005260:Female; D006801:Humans; D007668:Kidney / Q000098:blood supply* / Q000473:pathology; D007674:Kidney Diseases / Q000378:metabolism / Q000473:pathology*; D007678:Kidney Glomerulus / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000150:complications
D000682:Amyloid