title: Vascular effects of glucocorticosteroids, with special reference to budesonide.
abstract: The effect of glucocorticosteroids was tested on in vitro responses of tension developed by strips of umbilical blood vessels. 1. Hydrocortisone, methylprednisolone and dexametasone in concentrations of 10(-4)-10(-3) mainly inhibited spontaneous tone. Hydrocortisone and methylprednisolone induced a biphasic response with an initial small contraction followed by a more long lasting relaxation. 2. Budesonide, a novel powerful, non-halogenated steroid only induced a long lasting contraction. 3. The relaxation with hydrocortisone was of the same magnitude as after indomethacine, therefore, this response may be due to inhibition of prostaglandin-synthesis. 4. There was no leftward shift of the dose response curve to catecholamine stimulation but rather a slightly higher maximal response. There is no clear evidence of a uptake-2 blockade in our preparation.
mesh_terms: D019819:Budesonide; D003907:Dexamethasone / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D005438:Fludrocortisone / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011282:Pregnenediones / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology; D014469:Umbilical Arteries / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D005938:Glucocorticoids; D011282:Pregnenediones; D012701:Serotonin; D019819:Budesonide; D003907:Dexamethasone; D005438:Fludrocortisone; D009638:Norepinephrine; D004837:Epinephrine