title: [Clinical application of futraful suppositories in malignant head and neck cancer--effects of the therapy combined with radiation].
abstract: Futraful suppository 1.5 g per day was administered to 33 patients with head and neck malignancies. Among 33 cases which entered into the study, 16 cases were evaluated. Out of 16 evaluable cases, complete responses (CRs) were obtained in 4 cases and partial responses (PRs) in 7 cases, an overall response rate including 4 CRs and 7 PRs was 68.8%. Side effects due to FT-207 suppository were developed in 14 cases out of 33 patients (42.4%). Side effects such as anal pain, anorexia, diarrhea, pigmentation, exanthema and nail change were observed. No severe side effect was encountered.
mesh_terms: D000368:Aged; D005260:Female; D005472:Fluorouracil / Q000031:analogs & derivatives*; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013488:Suppositories; D005641:Tegafur / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D013488:Suppositories; D005641:Tegafur; D005472:Fluorouracil