Specific interaction of some non-steroidal compounds with the progesterone binding site of uteroglobin.
Uteroglobin binds progesterone with high affinity. A few substituted diphenyl ketones were observed to inhibit uteroglobin-progesterone binding in a dose-dependent manner. 4,4'-Dimethoxy-2-hydroxy benzophenone had relatively higher affinity for uteroglobin. The structure-activity relationship amongst the substituted diphenyl ketones indicated considerable sensitivity towards minor structural modifications. These observations offer a tool to investigate nonsteroidal compounds in relation to progesterone related functions of uteroglobin in pregnancy.
D000818:Animals; D001577:Benzophenones / Q000494:pharmacology*; D001665:Binding Sites; D004226:Dithioerythritol / Q000494:pharmacology; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D007659:Ketones / Q000494:pharmacology*; D011374:Progesterone / Q000378:metabolism*; D011485:Protein Binding; D011817:Rabbits; D013329:Structure-Activity Relationship; D014316:Tritium; D014598:Uteroglobin / Q000378:metabolism*
D001577:Benzophenones; D006023:Glycoproteins; D007659:Ketones; D014316:Tritium; D011374:Progesterone; D004226:Dithioerythritol; D014598:Uteroglobin