Histopathology induced by larval Terranova (Type HA) (Nematoda: anisakinae) in experimentally infected rats.
Terranova Type Hawaii A larvae, gavaged into the stomach of Wistar rats, demonstrated the ability to invade the stomach and intestinal tissues of the rat without penetrating the serosa. Lesions induced by these third-stage larvae were present in 25 of 37 (68%) inoculated rats. Larvae adhered to the mucosa of the stomach within 1 hr PI. Mucosal ulceration and acute, focal, hemorrhagic areas in the mucosa and submucosa were associated with most worm-penetrations. Reactions of inflammatory tissue occurred from 4 hr to 6 days PI and granulomas occurred by day 7 PI. Indurated craterlike lesions were noted 10 to 15 days PI. Resolving granulomas were present by day 30 PI. Chronic gastric ulcers were observed at day 30 PI.
D000818:Animals; D004386:Duodenum / Q000473:pathology*; D004487:Edema; D005753:Gastric Mucosa / Q000473:pathology; D006099:Granuloma / Q000473:pathology; D007249:Inflammation; D009336:Necrosis; D009348:Nematoda / Q000502:physiology; D009349:Nematode Infections / Q000469:parasitology / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000473:pathology*; D013276:Stomach Ulcer / Q000473:pathology