Creatine kinase BB isoenzyme in CSF in neurologic diseases. Measurement by radioimmunoassay.
The concentration of creatine kinase BB isoenzyme (CK BB) was measured by radioimmunoassay in CSF from 306 patients with various neurologic disorders. Levels above 2.0 ng/mL were not found in patients without neurologic disease. Whereas mean CSF CK BB level was less than 2.0 ng/mL in groups of patients with systemic malignant neoplasms, latent syphilis, peripheral neuropathy, disk disease, polyradiculopathy, myelopathy, multiple sclerosis, neurodegenerative disease, encephalopathy, and hydrocephalus, it was elevated in groups of patients with convulsive disorder, CNS neoplasm, cerebrovascular disease, vasculitis, and meningoencephalitis.
D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid / Q000201:enzymology; D003402:Creatine Kinase / Q000134:cerebrospinal fluid*; D006801:Humans; D007527:Isoenzymes; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid* / Q000201:enzymology; D009468:Neuromuscular Diseases / Q000134:cerebrospinal fluid / Q000201:enzymology; D011863:Radioimmunoassay
D007527:Isoenzymes; D003402:Creatine Kinase