title: An investigation of the genetic toxicology of irradiated foodstuffs using short-term test systems. III--In vivo tests in small rodents and in Drosophila melanogaster.
abstract: Six in vivo genetic toxicity tests were carried out on irradiated or unirradiated cooked chicken, dried dates and cooked fish. The tests were as follows: sex-linked recessive lethal mutations in Drosophila melanogaster (dried dates only), chromosome aberrations in bone marrow of Chinese hamsters, micronucleus test in rats, mice and Chinese hamsters, sister-chromatid exchange in bone marrow of mice and Chinese hamsters and in spermatogonia of mice, and DNA metabolism in spleen cells of Chinese hamsters. None of the tests provided any evidence of genetic toxicity induced by irradiation. However, dried dates, whether irradiated or not, showed evidence of some genetic toxicity in their effect on DNA metabolism in spleen cells and SCE induction in bone marrow. Feeding irradiated fish affected DNA metabolism in the spleen cells of Chinese hamsters. This effect could be interpreted as an induction of an immunoactive compound, although it could also be explained by the persistence of an immunoactive compound due to the removal by irradiation of spoilage organisms that would normally degrade it.
mesh_terms: D000818:Animals; D002645:Chickens; D006224:Cricetinae; D003412:Cricetulus; D004331:Drosophila melanogaster; D005260:Female; D005399:Fishes; D005514:Food Irradiation / Q000009:adverse effects*; D005638:Fruit / Q000528:radiation effects; D008297:Male; D008460:Meat / Q000528:radiation effects; D051379:Mice; D009152:Mutagenicity Tests; D009154:Mutation / Q000528:radiation effects*; D051381:Rats; D011919:Rats, Inbred Strains