[Role of renal and extrarenal mechanisms in the regulation of sodium blood levels after intravenous administration of hypertonic solution of sodium chloride to the rat].
I. v. administration of 1 M and 2 M NaCl solutions (0.17 ml per 100 g body mass) increased sodium concentration in the blood plasma by 2-5% within 10 min. Hypernatriemia and respective hyperosmia were accompanied by the decrease of the protein level in the blood. The amount of NaCl excretion by kidneys within 1.5 hrs was equal to 18 and 39% of the injected sodium load. Close positive correlation was found between the concentration of osmotically active substances in the blood and reabsorption level of osmotically free water in renal tubules. These data suggest existence of at least two mechanisms for regulation of shifts occurring in disturbances of sodium and osmotic balance: 1) extrarenal factor (physico-chemical-the loss of cell water and/or Na influx into the cell); 2) renal factor--an increase in urine Na excretion and osmotically free water reabsorption.
D000818:Animals; D004231:Diuresis; D005110:Extracellular Space / Q000502:physiology*; D005260:Female; D005919:Glomerular Filtration Rate; D007275:Injections, Intravenous; D007668:Kidney / Q000502:physiology*; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D012462:Saline Solution, Hypertonic; D012964:Sodium / Q000097:blood*; D012965:Sodium Chloride; D014882:Water-Electrolyte Balance
D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride; D012964:Sodium
Rol' pochek i ékstrarenal'nykh mekhanizmov v reguliatsii konstentratsii natriia v plazme krovi pri vnutrivennom vvedenii gipertonicheskogo rastvora khloristogo natriia kryse.