Two lines of Walker carcinoma 256: their peculiarities and different interactions with the host.
Two sublines of Walker 256 carcinoma have been characterized for their ability to metastasize and to induce cachexia. The invasive, metastasizing line A induced terminal anorexia in rats with a mean survival time of 27 +/- 1.5 days. The non-invasive line B induced early anorexia and cachexia with a mean survival time of only 15 +/- 1 days. At death, the line B tumor was still smaller than the line A one, and no metastases were detectable. These two sublines are discussed as a composite model for studying anorexia and cachexia together with invasion and metastasis.
D000818:Animals; D000855:Anorexia / Q000209:etiology; D001835:Body Weight; D002100:Cachexia / Q000209:etiology; D002279:Carcinoma 256, Walker / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D002460:Cell Line; D004326:Drinking; D004435:Eating; D007668:Kidney / Q000503:physiopathology; D009362:Neoplasm Metastasis; D051381:Rats