Interrelations between dopaminergic and GABA-ergic transmitter mechanisms in apomorphine stereotypy.
The effects of dopamine (DA)-ergic and GABA-ergic pharmacological agents on apomorphine stereotypy upon intraperitoneal administration in male albino rats has been studied. It has been found that: the DA-ergic agonist L-DOPA increases the intensity of apomorphine stereotypy, without influencing its total duration. The DA-ergic antagonist haloperidol inhibits significantly apomorphine stereotypy, with marked dose-effect dependence, shortening its duration. The GABA-ergic antagonist picrotoxin potentiates nearly twice apomorphine stereotypy and increases its duration. The GABA-ergic agonists depakine and aminooxyacetic acid (AOAA) inhibit substantially apomorphine stereotypy and shorten its duration. Participation of DA-ergic and GABA-ergic transmitter mechanisms in apomorphine stereotypy as well as interactions of these two transmitter systems in the nigrostriatum, are assumed.
D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*; D014635:Valproic Acid / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D000625:Aminooxyacetic Acid; D001058:Apomorphine; D004298:Dopamine; D006220:Haloperidol; D007980:Levodopa; D010852:Picrotoxin; D014635:Valproic Acid; D005680:gamma-Aminobutyric Acid