Acetaminophen poisoning in infancy.
Acetaminophen is widely used in children of all ages, and overdosage from this medication is common. Although severe hepatotoxicity from over-dosage occurs in adults, acetaminophen seems to have a wide margin of safety in younger children. This has been ascribed to altered pharmacokinetics in this age group. We report two cases in which severe acetaminophen-induced hepatoxocity occurred in two infants. Neither infant reportedly received potentially toxic dosages, by history, but toxic drug levels were present in both.
D000082:Acetaminophen / Q000378:metabolism / Q000506:poisoning*; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D006801:Humans; D007223:Infant; D008111:Liver Function Tests; D008297:Male
D000082:Acetaminophen