title: Comparative rates of metabolism of pipecolic acid in several animal species.
abstract: 1. The rate of metabolism of pipecolic acid, measured in liver and kidney, varied 1000 fold among 10 animal species. Degradation of L-pipecolic acid by kidney in rat and mouse was 0.11 and 0.31 pmoles/min/mg protein, respectively; in monkey and human. 3.0 and 6.5; in guinea-pig and rabbit 101 and 106. 2. Activity with D-pipecolic acid was consistently 50-60% higher than the L-isomer except in the rabbit. 3. Degradation of L-lysine presumably through the saccharopine-alpha-aminoadipic acid pathway, was effective in all species, contrasting with the variable performance in the pipecolic acid-alpha-aminoadipic acid pathway.
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D000882:Haplorhini; D006801:Humans; D007536:Isomerism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008239:Lysine / Q000378:metabolism; D051379:Mice; D010875:Pipecolic Acids / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
chemical_list: D010875:Pipecolic Acids; D008239:Lysine