Biochemical changes in liver and plasma of rats after oral administration of edifenphos.
Rats were treated, during 8 weeks, with different doses of edifenphos (0, 5, 10, 20, 40 mg/kg/day) incorporated in the food. Treatments with 20 and 40 mg/kg increased the relative liver weight and hepatic concentrations of phospholipids, microsomal proteins and cytochrome P450. Aminopyrine N-demethylase and aniline hydroxylase activities were increased at the same doses. Hepatic lipids and blood triacylglycerols remained unchanged by the treatment, but blood cholesterol increased significantly (33%) at 40 mg/kg. Plasma cholinesterase activity was slightly depressed in rats treated with the two higher doses. Under these experimental conditions, the dose of edifenphos, inducing no significant difference was 10 mg/kg/day.
D000284:Administration, Oral; D000818:Animals; D002802:Cholinesterases / Q000097:blood; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D008055:Lipids; D009946:Organothiophosphorus Compounds; C002108:edifenphos; D002802:Cholinesterases