title: The synthesis of 6,9-deepoxy-6,9-N-phenylimino-delta 6,8-prostaglandin I1. A novel inhibitor of leukotriene C and D synthesis.
abstract: The pyrrole analog of prostacyclin, 6,9-deepoxy-6,9-N-phenylimino-delta 6,8-prostaglandin I1 was synthesized from PGF2 alpha methyl ester. This pyrroloprostacyclin (U-60,257) and its methyl ester (U-56,467) have been shown to inhibit leukotriene C/D biosynthesis and antagonize leukotriene C/D contractions in vitro. Antigen induced bronchopulmonary changes in monkeys and guinea pigs are inhibited by U-60,257 in vivo.
mesh_terms: D000818:Animals; D001980:Bronchi / Q000187:drug effects; D011464:Epoprostenol / Q000138:chemical synthesis* / Q000494:pharmacology / Q000031:analogs & derivatives; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors; D006168:Guinea Pigs; D000882:Haplorhini; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D011453:Prostaglandins / Q000138:chemical synthesis*; D013189:SRS-A / Q000037:antagonists & inhibitors / Q000096:biosynthesis*
chemical_list: D011453:Prostaglandins; D013189:SRS-A; C035297:U 56467; D011464:Epoprostenol; D005982:Glutathione Transferase; C035296:piriprost