title: The mutagenicity of a cyanide antidote, dimethylaminophenol, in Chinese hamster cells.
abstract: The mutagenic activity of a cyanide antidote, dimethylaminophenol (DMAP), has been studied at the hypoxanthine-guanine-phosphoribosyltransferase (HPRT) locus in a line of Chinese hamster cells (V79), using induced resistance to 8-azaguanine as a marker for forward, point mutation. In a replating type of assay DMAP produced a dose-dependent increase in mutation frequency in suspension-treated cells, in the absence of any extrinsic metabolic activation system. The incorporation of a liver microsome preparation raised the concentration of DMAP required to induce mutation, but similar levels of induced mutation frequency (IMF) were produced.
mesh_terms: D000627:Aminophenols / Q000633:toxicity*; D000818:Animals; D001375:Azaguanine / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D066298:In Vitro Techniques; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats
chemical_list: D000627:Aminophenols; D009153:Mutagens; D001375:Azaguanine; C020292:4-dimethylaminophenol