Suppression of murine lymphocyte mitogen responses by exopolysaccharide from Capnocytophaga ochracea.
An extracellular polysaccharide was purified from culture supernatants of Capnocytophaga ochracea 25, a gram-negative bacillus associated with human periodontal disease. The extracellular polysaccharide suppressed in vitro mitogenic responses of murine splenic lymphocytes to concanavalin A and lipopolysaccharide. This suppression wad dose dependent, persisted up to 120 h, and was not caused by direct toxicity of the extracellular polysaccharide.
D000818:Animals; D002206:Capnocytophaga / Q000032:analysis*; D003208:Concanavalin A / Q000494:pharmacology; D041964:Cytophagaceae / Q000032:analysis*; D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D011135:Polysaccharides, Bacterial / Q000302:isolation & purification / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D003208:Concanavalin A