title: Relative carriage rates of nuclear dehydrogenating clostridia in two populations of different colorectal cancer risk.
abstract: Carriage of nuclear dehydrogenating clostridia has been associated with colon cancer and implicated in its aetiology. This study has compared the carriage of these organisms in a British population at high risk for the development of colon cancer with a low risk Nigerian population. Clostridia were found in all of the stools from both populations. Nuclear dehydrogenating clostridia were only found in the stools of the British subjects (32%). These results support the suggestion that the carriage rate of nuclear dehydrogenating clostridia in a population is related to the risk of colon cancer.
mesh_terms: D000328:Adult; D003013:Clostridium / Q000201:enzymology / Q000302:isolation & purification*; D003110:Colonic Neoplasms / Q000209:etiology*; D005243:Feces / Q000382:microbiology; D006801:Humans; D009549:Nigeria; D010088:Oxidoreductases / Q000378:metabolism; D012004:Rectal Neoplasms / Q000209:etiology*; D012306:Risk; D006113:United Kingdom
chemical_list: D010088:Oxidoreductases; C021936:3-oxo-5 beta-steroid delta 4-dehydrogenase