title: Infections with non-penicillinase-producing Neisseria gonorrhoeae treated with cefuroxime: treatment failures.
abstract: Two men who acquired acute gonococcal urethritis in The Netherlands and who were treated with cefuroxime (1.5 g given intramuscularly) failed to respond to this therapy. Pre- and post-treatment isolates of Neisseria gonorrhoeae from these patients had MICs of 0.5 and 1.0 microgram of cefuroxime/ml.
mesh_terms: D000328:Adult; D002444:Cefuroxime / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D006069:Gonorrhea / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000201:enzymology; D010405:Penicillinase / Q000096:biosynthesis; D014526:Urethritis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D002511:Cephalosporins; D010405:Penicillinase; D002444:Cefuroxime