Ethambutol dose-plasma level correlation studies in guinea pigs.
Plasma ethambutol concentration-time curves, determined in guinea pigs after 50, 100, or 200 mg/kg single oral doses, were compared with those reported for other species. The plasma concentration-time curve associated with antituberculosis activity in mouse, monkey, and humans could not be reproduced in guinea pigs. In guinea pigs, the rate of ethambutol elimination from plasma (40-min half-life) was 4 times faster than that reported for the mouse or for humans (161-min half-life). This finding tends to negate extrapolation of ethambutol dose-plasma concentration data from other species to guinea pig studies intended to predict clinical utility.
D000818:Animals; D004195:Disease Models, Animal; D004977:Ethambutol / Q000008:administration & dosage* / Q000097:blood; D005260:Female; D006168:Guinea Pigs; D008297:Male; D014376:Tuberculosis / Q000188:drug therapy*
D004977:Ethambutol