Altered hindlimb extension in the rat after DSP-4: a useful marker of central noradrenergic depletion.
Rats treated with DSP-4, a selective noradrenergic neurotoxin, usually exhibited an attenuation of hindlimb extension when suspended by the tail. Those animals showing the reduced extension had no post-decapitation reflex (PDR), whereas those animals having a normal extension had the PDR. On this basis, rats injected with DSP-4 can be readily screened for an effective or ineffective noradrenergic lesion. Preliminary evidence suggests that the alpha 2-adrenoceptor is involved in the regulation of hindlimb extension.
D000588:Amines / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001596:Benzylamines / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D003000:Clonidine / Q000494:pharmacology; D004347:Drug Interactions; D006614:Hindlimb; D008297:Male; D009498:Neurotoxins / Q000494:pharmacology*; D009638:Norepinephrine / Q000502:physiology*; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D015016:Yohimbine / Q000494:pharmacology
D000588:Amines; D001596:Benzylamines; D009498:Neurotoxins; D015016:Yohimbine; D003000:Clonidine; C012102:DSP 4; D009638:Norepinephrine; D011224:Prazosin