The effect of a benzodiazepine antagonist, RO15-1788, in diazepam dependent rats.
A benzodiazepine antagonist, RO15-1788, was administered intragastrically to diazepam-dependent gastric fistula rats and a precipitated abstinence syndrome was observed. The intensity of the RO15-1788 precipitated abstinence syndrome, calculated by the Precipitated Abstinence Scale, increased in intensity in a log-dose manner over a dose range of 1.0 to 15.0 mg/kg of RO15-1788 and plateaued at the 15.0 mg/kg dose. The RO15-1788 precipitated diazepam abstinence syndrome differed both qualitatively and quantitatively from the diazepam withdrawal syndrome.
D000818:Animals; D001569:Benzodiazepines / Q000037:antagonists & inhibitors*; D001570:Benzodiazepinones / Q000494:pharmacology*; D003975:Diazepam; D004305:Dose-Response Relationship, Drug; D005260:Female; D005442:Flumazenil; D006801:Humans; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome; D019966:Substance-Related Disorders
D001570:Benzodiazepinones; D001569:Benzodiazepines; D005442:Flumazenil; D003975:Diazepam