title: Pituitary-thyroid axis after bilateral orchiectomy in men.
abstract: The functional interaction between the testis and thyroid was evaluated in 13 patients affected by prostatic carcinoma before and after bilateral orchiectomy. Two different patterns of thyroid hormones were noted. Immediately after surgery, free thyroxine (T4) increased and total triiodothyronine (T3) decreased probably as a result of surgical stress at anesthesia. Later, free T4 levels decreased while total T4 and thyroxine binding globulin (TBG) were unchanged. Such changes may be due to qualitative changes in binding proteins.
mesh_terms: D000368:Aged; D002369:Castration; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000502:physiology*; D011471:Prostatic Neoplasms / Q000601:surgery; D013961:Thyroid Gland / Q000502:physiology*; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000097:blood; D013975:Thyroxine-Binding Proteins / Q000378:metabolism; D014284:Triiodothyronine / Q000097:blood
chemical_list: D013975:Thyroxine-Binding Proteins; D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D013974:Thyroxine