Neurotoxic lesions of ventrolateral but not anteromedial neostriatum in rats impair differential reinforcement of low rates (DRL) performance.
In two separate experiments, rats received either kainic acid (KA), 6-hydroxydopamine (6-OHDA) or control lesions bilaterally into either the anteromedial or ventrolateral neostriatum. Both ventrolateral neurotoxic lesions disrupted post-operative body weight regulation and the acquisition of a DRL-20 sec operant schedule of reinforcement. The pattern of operant responding suggested that these animals had an impairment in response sequencing or switching. Rats with anteromedial lesions manifested neither body-weight nor DRL impairments.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001931:Brain Mapping; D002421:Caudate Nucleus / Q000502:physiology; D003216:Conditioning, Operant / Q000502:physiology*; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D005625:Frontal Lobe / Q000502:physiology; D006892:Hydroxydopamines / Q000633:toxicity; D007608:Kainic Acid / Q000633:toxicity; D008297:Male; D011939:Mental Recall / Q000502:physiology; D016627:Oxidopamine; D011699:Putamen / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012055:Reinforcement Schedule
D006892:Hydroxydopamines; D016627:Oxidopamine; D007608:Kainic Acid