[Effect of vitamin K3 on the redox chain enzyme activity of the rat liver endoplasmic network and the hydroxylation of amidopyrine, ethylmorphine and aniline].
A single subcutaneous injection of vitamin K3 into male rats activates NADP H-ferritochromo-c-oxidoreductase in membranes of hepatocyte endoplasmic reticulum. As the vitamin dose is raised up to 50 mg/kg, the function of NADP . H-nitrotetrasolium-reductases also increases. Administration of the vitamin in a dose of 70 mg/kg per os for 10 days brings about activation of NADP . H- and NADP . H-nitrotetrasolium-reductases along with an appreciable increase in the rate of N-demethylation of amidopyrine and p-hydroxylation of aniline.
D000632:Aminopyrine / Q000378:metabolism* / Q000494:pharmacology*; D000814:Aniline Compounds / Q000378:metabolism*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004721:Endoplasmic Reticulum / Q000187:drug effects* / Q000201:enzymology; D005036:Ethylmorphine / Q000378:metabolism*; D006900:Hydroxylation; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009022:Morphine Derivatives / Q000378:metabolism*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D013997:Time Factors; D014812:Vitamin K / Q000031:analogs & derivatives* / Q000494:pharmacology; D024483:Vitamin K 3
D000814:Aniline Compounds; D009022:Morphine Derivatives; D000632:Aminopyrine; D014812:Vitamin K; D024483:Vitamin K 3; D009247:NADH, NADPH Oxidoreductases; D005036:Ethylmorphine
Vliianie vitamin K3 na aktivnost' fermentov redoks-tsepeĭ éndoplazmaticheskoĭ seti pecheni krys i gidroksilirovanie amidopirina, étilmorfina i anilina.