Lactose malabsorption and tolerance of lactose-hydrolyzed milk. A double-blind controlled crossover study.
Eleven lactose-intolerant patients were investigated in a double-blind crossover controlled study. In random sequence they received 500 ml of either ordinary cow milk (lactose content, 25 g) or the same amount of low-lactose milk (85% of the lactose hydrolyzed), which had been processed by Lactozym 3000 L for 24 h at 4 degrees C. A significantly increased blood glucose rise from fasting levels was demonstrated in the low-lactose tests. Similarly, a significant reduction of liquid stool frequency, abdominal colics, distention, borborrhygmia, and flatulence was demonstrated. It was concluded that further studies, including long-term treatment of lactose-intolerant children, are indicated.
D000328:Adult; D000368:Aged; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002417:Cattle; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006868:Hydrolysis; D007785:Lactose / Q000378:metabolism; D007787:Lactose Intolerance / Q000178:diet therapy*; D008297:Male; D008875:Middle Aged; D008892:Milk; D011897:Random Allocation; D001616:beta-Galactosidase / Q000008:administration & dosage
D001786:Blood Glucose; D001616:beta-Galactosidase; D007785:Lactose