[Transplantation of islands of Langerhans: inclusion of living cells into a polymer forming a net-like structure].
A two-component polyacrylic amide gel forming a net-like structure was built up on pancreatic cells. In such a way the transplanted cells could be protected from the damage by immune protein with big molecule. The method was tested in yeast cells before, human erythrocytes, and wether erythrocytes. It was shown that the polymerisation and the inclusion method do not influence essentially the vitality of the examined cells. It was demonstrated by means of the complement fixation reaction that the included erythrocytes cannot be damaged by the immune protein with big molecule. Metabolic processes of the included pancreas beta cells were provable by diffusion. The experiments promise that the included cells survive after the transplantation and the polyacrylic amide gel protects the cells from the impairing effect of the immune protein.
D000180:Acrylic Resins; D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D002417:Cattle; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology; D016381:Islets of Langerhans Transplantation; D051381:Rats
D000180:Acrylic Resins; C016680:polyacrylamide gels; D002245:Carbon Dioxide
Fragen zur Transplantation von Langerhans-Inseln: Der Einschluss von lebenden Zellen in ein Polymer, welches eine netzförmige Struktur bildet.