Effect of anti-eosinophil serum on phospholipase B activity in mice infected with Trichinella spiralis.
Anti-eosinophil serum (AES) was administered to mice infected with 400 Trichinella spiralis larvae and its effect on peripheral eosinophilia and intestinal phospholipase B activity was assayed. The AES caused a significant, temporally related, suppression in both peripheral eosinophilia and phospholipase B activity when compared to responses found in infected mice given normal rabbit serum. The findings support the hypothesis that a parasite-induced eosinophilia is the source of elevated phospholipase B activity present in parasitized tissues.
D000818:Animals; D004804:Eosinophils / Q000276:immunology / Q000502:physiology*; D007106:Immune Sera / Q000494:pharmacology; D007422:Intestines / Q000201:enzymology*; D007958:Leukocyte Count; D008245:Lysophospholipase / Q000378:metabolism*; D008297:Male; D051379:Mice; D010740:Phospholipases / Q000378:metabolism*; D014235:Trichinellosis / Q000097:blood / Q000201:enzymology*
D007106:Immune Sera; D010740:Phospholipases; D008245:Lysophospholipase