title: A placebo controlled study of the cardiovascular effects of fluvoxamine and clovoxamine in human volunteers.
abstract: 1 Fluvoxamine and clovoxamine, two new potential antidepressants were given to 27 healthy male volunteers in a double-blind, placebo controlled, three-way crossover study. 2 Neither compound affected the electrical intervals of 24 h ambulant electrocardiographic monitoring with the exception of a small increase in R-R interval. 3 There were no changes in blood pressure measurements. 4 The only notable unwanted symptom was nausea for both fluvoxamine and clovoxamine.
mesh_terms: D000928:Antidepressive Agents / Q000009:adverse effects / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D016666:Fluvoxamine; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010091:Oximes / Q000009:adverse effects / Q000494:pharmacology*; D010919:Placebos; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents; D010091:Oximes; D010919:Placebos; C020724:clovoxamine; D016666:Fluvoxamine