Polymer analogs of 3-chloro-4-benzyloxyphenylacetic acid and their pharmacological activity.
Polymer analogs of 3-chloro-4-benzyloxy-phenylacetic acid (BPh) were prepared, representing esters of BPh with three polymer alcohols: poly(vinyl alcohol) (P-I), poly(2-hydroxyethyl methacrylate) (P-II), and poly(2,3-dihydroxypropyl methacrylate) (P-III). Their anti-inflammatory activity was determined by testing their inhibitory effect on the growth of edema in the hind legs of rats. The relative activities of the esters P-I-BPh and P-II-BPh with respect to that of BPh are 0.06 and 0.10, respectively. In the case of P-III-BPh the activity is stronger (0.37), probably owing to the easier release of BPh from P-III-BPh due to hydrolysis. No prolonged effect of BPh polymeric esters could be achieved.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D010648:Phenylacetates / Q000494:pharmacology*; D011102:Polyhydroxyethyl Methacrylate / Q000494:pharmacology; D011108:Polymers / Q000494:pharmacology*; D011109:Polymethacrylic Acids / Q000494:pharmacology*; D011142:Polyvinyl Alcohol / Q000494:pharmacology; D051381:Rats
D000893:Anti-Inflammatory Agents; D010648:Phenylacetates; D011108:Polymers; D011109:Polymethacrylic Acids; D011102:Polyhydroxyethyl Methacrylate; C009932:polyglycerylmethacrylate; C023677:3-chloro-4-benzoyloxyphenylacetic acid; D011142:Polyvinyl Alcohol