title: Erythrocyte cation content, globin chain synthesis and glucose metabolism in dysmyelopoietic syndromes.
abstract: Red blood cells (RBC) from 13 patients suffering from dysmyelopoietic syndromes (DMPS) have been studied. About half of these subjects showed an abnormal Na+ and K+ leakage of their RBC, which were incubated at 37 degrees C for 24 h. The mean rate of the glycolytic pathway increased significantly and the glycolysis values correlated well with the Na+ gain. Moreover, 9 out of the 13 patients showed an abnormal biosynthetic ratio of haemoglobin chains in their reticulocytes. Since the multiple defects in DMPS erythrocytes do not seem clearly linked by cause-effect relationships, they probably derive from several cooperating factors in pathological erythroid precursors, leading to RBC membrane damage.
mesh_terms: D000368:Aged; D000741:Anemia, Aplastic / Q000097:blood; D000756:Anemia, Sideroblastic / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001855:Bone Marrow Diseases / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D004920:Erythropoiesis; D005260:Female; D005914:Globins / Q000096:biosynthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D012156:Reticulocytes / Q000378:metabolism; D012964:Sodium / Q000097:blood; D013577:Syndrome; D013789:Thalassemia / Q000097:blood
chemical_list: D001786:Blood Glucose; D005914:Globins; D012964:Sodium; D011188:Potassium