Postpartum hemophilia.
An acquired circulating inhibitor to Factor VIII:C was found in a 27-year-old postpartum woman who presented with ecchymoses and hematomas. Postpartum Factor VIII:C inhibitors can clinically manifest with signs and symptoms not unlike those in a classic hemophiliac. The natural history of this inhibitor is typically one of spontaneous disappearance with the return of the patient's previous hemostatic capacity. The authors describe a patient with the postpartum Factor VIII:C inhibitor, and discuss this unusual disease entity along with the therapeutic considerations.
D000328:Adult; D001780:Blood Coagulation Tests; D005169:Factor VIII / Q000037:antagonists & inhibitors / Q000502:physiology; D005260:Female; D006467:Hemophilia A / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D011247:Pregnancy; D011644:Puerperal Disorders / Q000097:blood / Q000175:diagnosis*
D005169:Factor VIII