Benzoyl peroxide and epidermal wound healing.
The effectiveness of 10%, 20%, and 50% benzoyl peroxide in a lotion, 20% benzoyl peroxide in a gel, and the effect of the vehicles alone on wound reepithelialization were evaluated in young domestic pigs. Twenty percent benzoyl peroxide suspension in a lotion base substantially increased the rate of reepithelialization by 33% over a seven-day evaluation period. Twenty percent benzoyl peroxide suspension in a gel base and 10% benzoyl peroxide suspension in a lotion base slightly enhanced epidermal resurfacing, while 50% benzoyl peroxide suspension in a lotion base and the vehicle gel retarded healing. Variations in the rate of reepithelialization were observed when different lots of 20% benzoyl peroxide lotions were compared. Chemical analysis of each of the 20% benzoyl peroxide preparations tested disclosed great differences in zinc, magnesium, and sodium content.
D000818:Animals; D001585:Benzoyl Peroxide / Q000008:administration & dosage / Q000494:pharmacology*; D005782:Gels; D010545:Peroxides / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects*; D013535:Suspensions; D013552:Swine; D014945:Wound Healing / Q000187:drug effects*
D005782:Gels; D010545:Peroxides; D013535:Suspensions; D001585:Benzoyl Peroxide