title: Development and evaluation of pulsatile roller pump and tubing for cardiac assistance.
abstract: In our laboratories we have developed a roller pump for cardiopulmonary bypass and circulatory assistance that has the ability to produce steady or pulsatile flow. The pulsatile mode can also be used for counterpulsation. The roller pump has been tested both experimentally and clinically. Studies have also been performed in vitro and in vivo to evaluate and select the best medical-grade roller pump tubing to be used in the pump for short- and long-term support. In vitro tests included rebounding of tubing volume versus revolutions per minute, rebounding over time with continuous pumping, flex life, and spallation. In vivo testing was performed in mongrel dogs using heparinless left heart bypass pumping for 6 h. Hematologic studies were performed during the procedure. Postmortem examination was performed, looking especially for thromboembolism. The tubing and connectors were also inspected. The results of the in vivo and in vitro tests of all tubings were then compared.
mesh_terms: D000818:Animals; D001243:Assisted Circulation / Q000295:instrumentation*; D004285:Dogs; D004867:Equipment Design; D005069:Evaluation Studies as Topic; D006355:Heart-Lung Machine; D066298:In Vitro Techniques