Chromosomal aberrations and sister-chromatid exchanges in workers exposed to styrene.
Few studies exist about chromosomal damage in workers occupationally exposed to styrene. In the present study, chromosomal aberrations and SCEs were analyzed from cultures of peripheral lymphocytes of workers employed in 6 different reinforced-plastics industries with styrene air exposure levels ranging from 30 to 400 mg/mc. A control group was selected on the base of sex, age and smoking habit. We examined 50-h cultures (for chromosomal-aberrations) and 72-h cultures (for SCEs) for each individual. All workers exposed to styrene, as compared with controls, showed significantly increased frequencies of chromosomal aberrations, while SCEs were significantly increased at 4 of the 6 plants. High SCE values appeared with styrene air concentrations higher than 200 mg/mc. Apart from the possible presence and role of other interfering chemicals in the various plants, chromosomal aberrations seem to be more sensitive than SCEs for the detection of chromosomal damage caused by exposure to low doses of styrene.
D002869:Chromosome Aberrations / Q000187:drug effects*; D003434:Crossing Over, Genetic / Q000187:drug effects*; D004781:Environmental Exposure; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013343:Styrenes / Q000494:pharmacology*
D013343:Styrenes