Further evidence on the effect of vitamin E on the cholesterol distribution in lipoproteins with special reference to HDL subfractions.
Earlier claims that oral administration of alpha-tocopherol results in significant and considerable increase in the serum total HDL concentration could not be substantiated. The present investigation does, however, show that lipoproteins are affected by alpha-tocopherol in other ways, the main effects being an increase in LDL-cholesterol and also in the HDL3-V cholesterol, an HDL3-subfraction determined by polyacrylamide gel electrophoresis. The established lipoprotein risk indices (LDL/HDL and HDL3/HDL2 ratios) were unfavorably affected as a result of alpha-tocopherol treatment. It is concluded that on the basis of available evidence, there is no reason to believe that alpha-tocopherol has a role to play in the prevention and treatment of atherosclerotic disease.
D000328:Adult; D001161:Arteriosclerosis / Q000188:drug therapy; D002784:Cholesterol / Q000032:analysis*; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D008075:Lipoproteins, HDL / Q000032:analysis* / Q000097:blood*; D008077:Lipoproteins, LDL / Q000032:analysis; D008297:Male; D014810:Vitamin E / Q000494:pharmacology* / Q000627:therapeutic use
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014810:Vitamin E; D002784:Cholesterol