Delay of diethylnitrosamine-induced hepatoma in rats by carrot feeding.
Carcinogenesis and death caused by diethylnitrosamine(DENA)-induced hepatomas in Sprague Dawley rats can be significantly delayed by feeding only carrots for several days a week. As this result is not obtained by supplementing food with even higher concentrations of synthetic beta-carotene, there must be several other factors which--together with the carotenoid--contribute to the positive effect. Several other possibilities such as effects of fasting, direct interactions with the carcinogen, resorption, vitamin A storage in the liver, etc., are proposed and discussed.
D000818:Animals; D004032:Diet; D004052:Diethylnitrosamine; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000401:mortality; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014675:Vegetables; D014801:Vitamin A / Q000494:pharmacology*
D014801:Vitamin A; D004052:Diethylnitrosamine