title: Regulation of the macrophage content of neoplasms by chemoattractants.
abstract: Factor chemotactic for mononuclear phagocytes was found in supernatant fluids of cultured human and mouse tumor cells. In 11 mouse tumors there was a correlation observed between chemotactic activity and macrophage content of neoplastic tissues. Tumor-derived chemoattractants appear to participate in the regulation of tumor-associated macrophages.
mesh_terms: D000818:Animals; D002460:Cell Line; D002630:Chemotactic Factors / Q000502:physiology*; D006801:Humans; D007938:Leukemia / Q000276:immunology; D008223:Lymphoma / Q000276:immunology; D008264:Macrophages / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000276:immunology* / Q000503:physiopathology; D009374:Neoplasms, Experimental / Q000276:immunology; D012509:Sarcoma / Q000276:immunology
chemical_list: D002630:Chemotactic Factors