Induction of T cell proliferation and lymphokine production by monoclonal antibody.
The studies of the biological effects of OKT3 monoclonal antibody on mature human T cells demonstrate that binding to a differentiation antigen by an antibody can modulate the specialized functions of the cells bearing the antigen. OKT3 induces T cells to proliferate and to secrete gamma interferon. The antibody also inhibits cytotoxic T cells from lysing target cells. The mechanisms involved and the nature of the antigen to which OKT3 binds are discussed.
D000911:Antibodies, Monoclonal / Q000276:immunology*; D002455:Cell Division; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D007141:Immunoglobulin Fc Fragments / Q000276:immunology; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000096:biosynthesis; D008222:Lymphokines / Q000096:biosynthesis*; D009000:Monocytes / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D008222:Lymphokines; D007371:Interferon-gamma