Diagnostic significance of transtympanic electrocochleography in Menière's disease.
Transtympanic electrocochleography (ECoG) was performed on 32 normal ears, 40 ears affected by hair cell damage without any evidence of endolymphatic hydrops (sensory damage) and 44 ears affected by established Menière's disease. The amplitude of the summating potential (SP) and the amplitude of the action potential (AP) were measured at a click stimulus intensity level of 100 dB HL. The SP amplitude was expressed as a percentage of the AP amplitude. In normal ears, the mean SP/AP ratio was 25% (range 10%-63%). In sensory damage, the SP/AP ratio was 13% (range 0%-29%), and in Menière's ears, the SP/AP ratio was 51% (range 29%-89%). In this series, an SP/AP ratio of 29% provided a diagnostic dividing mark between the sensory damage and Menière's-affected ears. Although this precise division was probably fortuitous, it does suggest that ECoG is a useful tool in the differential diagnosis of these two types of cochlear disorders.
D000200:Action Potentials; D000328:Adult; D001299:Audiometry / Q000379:methods*; D001300:Audiometry, Evoked Response / Q000379:methods*; D006198:Hair Cells, Auditory / Q000503:physiopathology; D006319:Hearing Loss, Sensorineural / Q000503:physiopathology; D006801:Humans; D008575:Meniere Disease / Q000175:diagnosis*; D008875:Middle Aged