Radiation-induced changes in production of prostaglandins F2 alpha, E, and thromboxane B2 in guinea pig parenchymal lung tissues.
At 1 hour to 4 days after unilateral exposure of guinea pigs to a single dose (0 X 5, 1 X 5, or 3 X 0 Gy) of gamma-radiation, changes were detected in prostaglandin and thromboxane concentrations in parenchymal lung tissues. At 1-3 hours after exposure, tissue levels of PGF2 alpha, PGE, and thromboxane B2 were significantly elevated in animals receiving 3 X 0 Gy, with the magnitude of alteration revealing a radiation dose effect. By 24 hours, tissue prostaglandin and thromboxane levels returned to near control values. Lung tissue synthesis of prostaglandins in response to H-1 receptor stimulation by the exogenous addition of histamine revealed similar radiation dose effects. The carboxylic acid ionophore A23187, exogenously applied to lung tissues, revealed a transient peak of increased sensitivity to ionophore stimulation for TxB2 synthesis at 24 hours and for PGF2 alpha at 72 hours post-irradiation. The data suggest that significant alterations in prostaglandin and thromboxane concentrations in parenchymal lung tissues occur following irradiation, in a dose-dependent manner, and that altered responsiveness to H-1 receptor stimulation and divalent cation transport also occur.
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D003037:Cobalt Radioisotopes; D005720:Gamma Rays; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D008168:Lung / Q000378:metabolism / Q000528:radiation effects*; D008297:Male; D011458:Prostaglandins E / Q000096:biosynthesis*; D011460:Prostaglandins F / Q000096:biosynthesis*; D013929:Thromboxane B2 / Q000096:biosynthesis*; D013931:Thromboxanes / Q000096:biosynthesis*; D013997:Time Factors; D014916:Whole-Body Irradiation
D003037:Cobalt Radioisotopes; D011458:Prostaglandins E; D011460:Prostaglandins F; D013931:Thromboxanes; D000001:Calcimycin; D013929:Thromboxane B2; D006632:Histamine