Curative effect of alpha-difluoromethylornithine on fatal Trypanosoma congolense infection in mice.
The curative effect of alpha-difluoromethylornithine (DFMO) on fatal T. congolense infection in mice was investigated using various concentrations administered orally in drinking water. Permanent cure was achieved in mice receiving 4% for 3 days or 2% for 5 days. Mice receiving less became parasitemic again but then, without any further treatment, resisted death due to trypanosomes for an average of 34.5 days, while untreated controls were dead within 8 days after trypanosomes were first seen in their blood.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D000518:Eflornithine; D005260:Female; D009115:Muridae; D009952:Ornithine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014353:Trypanosomiasis, African / Q000188:drug therapy*
D014344:Trypanocidal Agents; D009952:Ornithine; D000518:Eflornithine