Strong association between an HLA-DR antigen and thyroid carcinoma.
A group of 20 patients affected with thyroid carcinoma, all from Southern Italy, was typed for HLA-A, -B, -C and -DR antigens. Sixteen of them (80%) typed for DR1, while in the control group (120 unrelated healthy individuals from the same region) only 22 (18.3%) shared the same antigen (chi 2 = 32.96). The data indicate a highly significant association between the HLA-DR1 gene and the thyroid carcinoma.
D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D002291:Carcinoma, Papillary / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D005260:Female; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000235:genetics; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D007558:Italy; D008297:Male; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*
D006680:HLA Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II