L-Serine deaminase activity is induced by exposure of Escherichia coli K-12 to DNA-damaging agents.
The synthesis of L-serine deaminase in Escherichia coli K-12 was induced after exposure of cells to a variety of DNA-damaging agents, including UV irradiation, nalidixic acid, and mitomycin C. Synthesis was also induced during growth at high temperature. A mutant constitutive for SOS functions showed an elevated level of L-serine deaminase activity. The response to DNA-damaging agents thus may be mediated via the SOS system.
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology* / Q000528:radiation effects; D012695:L-Serine Dehydratase / Q000235:genetics*; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology*; D009268:Nalidixic Acid / Q000494:pharmacology*; D013696:Temperature; D014466:Ultraviolet Rays
D000903:Antibiotics, Antineoplastic; D008937:Mitomycins; D009268:Nalidixic Acid; D016685:Mitomycin; D012695:L-Serine Dehydratase