title: [Non A, non B-hepatitis in children].
abstract: Between 1975 and 1980, 10 children with acute and 8 children with chronic hepatitis type Non A, NON B (NANB) were seen in our hospital. Parenteral inoculation was probable in 10 cases. Hepatitis NANB was diagnosed in about 11% of all children with acute viral hepatitis who were admitted over this period. Children with parenterally acquired disease were more frequently anicteric and had less pronounced transaminase elevation than "sporadic" cases. An uncomplicated outcome was observed in only three of the ten children. Two patients died from acute liver failure, chronic hepatitis developed in three other children. The 9 children with chronic hepatitis NANB are representing 17% of all patients with chronic hepatitis who were seen in our clinic between 1975 and 1980. In six children with CPH a benign course was observed whereas three children with CAH were severely ill including portal hypertension. Immunosuppressive therapy was tried in two cases without success. In children as well as in adult patients, acute hepatitis NANB apparently has more frequently a prolonged course or progression to chronic liver disease than acute hepatitis of other etiology. It seems that CPH NANB shows a similarly benign course as chronic persistent hepatitis B. CAH NANB in our patients, however, had a poorer prognosis than CAH type B.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000367:Age Factors; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006526:Hepatitis C / Q000175:diagnosis* / Q000201:enzymology; D006525:Hepatitis, Viral, Human / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D008297:Male; D011379:Prognosis
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
vernacular_title: Nicht-A, Nicht-B-Hepatitis im Kindesalter.