The effect of methionine on the accumulation of ornithine by Chinese hamster cells in culture.
Ornithine was found to be toxic to cells that lack ornithine aminotransferase (EC 2.6.1.13). These cells also accumulated substantial amounts of ornithine. The addition of methionine to these cells protected them from the toxic effects of ornithine and also diminished their accumulation of ornithine. Cells that have an active ornithine aminotransferase were resistant to the toxic effects of ornithine, and accumulated less of this compound.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D008715:Methionine / Q000494:pharmacology*; D009952:Ornithine / Q000378:metabolism* / Q000494:pharmacology; D010053:Ovary
D008715:Methionine; D009952:Ornithine