title: Concerning the decarboxylation of 3-carboxysalsolinol.
abstract: 3-Carboxysalsolinol (14C-COOH) was prepared from DOPA (1-14C). Both in vitro and in vivo studies were conducted to examine the possibility that this amino-acid tetrahydroisoquinoline is converted to salsolinol in a parallel manner to the formation of dopamine from its amino-acid precursor. The results showed that this is not so for DOPA is decarboxylated far more readily than is 3-carboxysalsolinol. Small quantities of carbon dioxide (14C) are liberated from 3-carboxysalsolinol (14C-COOH), but this may reflect non-enzymatic decarboxylation.
mesh_terms: D000818:Animals; D003653:Decarboxylation; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D006168:Guinea Pigs; D007546:Isoquinolines / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008297:Male; D009115:Muridae; D012490:Salsoline Alkaloids / Q000378:metabolism*
chemical_list: D007546:Isoquinolines; D012490:Salsoline Alkaloids; C011704:carboxysalsolinol; D004295:Dihydroxyphenylalanine