Preclinical ocular evaluation of noncorticosteroidal antiinflammatory agents.
The nature of inflammation in general and the special aspects of ocular inflammation are discussed. Causes of inflammation, the cellular and tissue response to noxious stimuli and the biochemical mediation of the inflammatory response are described. Prostaglandins and their relatives the thromboxanes and prostacyclins are shown to play an important role in the mediation of ocular inflammation. Inhibitors of the biochemical synthesis of prostaglandins show strong potential for use in topical ocular antiinflammatory therapy, however their preclinical evaluation requires the choice of a suitable animal model. A review of animals of both specific and general ocular inflammation is presented.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000937:Antigen-Antibody Reactions; D001327:Autoimmune Diseases / Q000276:immunology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D009877:Endophthalmitis / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D006168:Guinea Pigs; D000882:Haplorhini; D007111:Immunity, Cellular; D008722:Methods; D010587:Phagocytosis; D011448:Prostaglandin Antagonists / Q000627:therapeutic use*; D011453:Prostaglandins / Q000502:physiology; D011817:Rabbits
D000893:Anti-Inflammatory Agents; D011448:Prostaglandin Antagonists; D011453:Prostaglandins