An analysis of the effects of systemically administered clonidine on the food and water intake of rats.
1 It is known that intracerebral injections of clonidine can induce eating in rats but it has not been clear whether systemic administration can produce similar effects. 2 Subcutaneous injections of clonidine (0.01, 0.03, 0.1 mg/kg) increased food and water intake during the 6 h period following injection in non-deprived male rats. 3 Pretreatment with a dose of yohimbine (1.0 mg/kg) shifted the clonidine dose-response curves to the right, suggesting competitive antagonism. 4 A dose of naloxone (0.1 mg/kg) produced a lowering of the clonidine dose-response curve but statistical analysis suggested that the opiate antagonist did not produce a competitive antagonism of the effect of clonidine. 5 The results are consistent with a role for alpha 2-adrenoceptors in appetite regulation.
D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D004326:Drinking / Q000187:drug effects*; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects*; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D015016:Yohimbine / Q000494:pharmacology
D015016:Yohimbine; D009270:Naloxone; D009020:Morphine; D003000:Clonidine