Release of thyrotropin releasing hormone into hypophysial portal blood is high relative to other neuropeptides and may be related to prolactin secretion.
The amount of immunoreactive TRH released into hypophysial portal blood of female rats was about 2 orders of magnitude greater than gonadotropin releasing hormone and somatostatin. The turnover of TRH, as high as 80% of the total hypothalamic content per hour, was also much greater than that of any other known peptide. TRH release increased during the expected proestrous surge of prolactin and also in some animals during suckling.
D000818:Animals; D005260:Female; D007031:Hypothalamus / Q000032:analysis; D007700:Kinetics; D010907:Pituitary Hormones / Q000378:metabolism*; D011247:Pregnancy; D011301:Preoptic Area / Q000032:analysis; D011359:Proestrus; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013973:Thyrotropin-Releasing Hormone / Q000097:blood / Q000378:metabolism*
D010907:Pituitary Hormones; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin