Relative carriage rates of nuclear dehydrogenating clostridia in two populations of different colorectal cancer risk.
Carriage of nuclear dehydrogenating clostridia has been associated with colon cancer and implicated in its aetiology. This study has compared the carriage of these organisms in a British population at high risk for the development of colon cancer with a low risk Nigerian population. Clostridia were found in all of the stools from both populations. Nuclear dehydrogenating clostridia were only found in the stools of the British subjects (32%). These results support the suggestion that the carriage rate of nuclear dehydrogenating clostridia in a population is related to the risk of colon cancer.
D000328:Adult; D003013:Clostridium / Q000201:enzymology / Q000302:isolation & purification*; D003110:Colonic Neoplasms / Q000209:etiology*; D005243:Feces / Q000382:microbiology; D006801:Humans; D009549:Nigeria; D010088:Oxidoreductases / Q000378:metabolism; D012004:Rectal Neoplasms / Q000209:etiology*; D012306:Risk; D006113:United Kingdom
D010088:Oxidoreductases; C021936:3-oxo-5 beta-steroid delta 4-dehydrogenase