The DiGeorge syndrome and the fetal alcohol syndrome.
Four patients with clinical and laboratory features of the DiGeorge syndrome had a definite history of maternal alcoholism. Certain clinical abnormalities in the patients were characteristic of the DiGeorge syndrome as well as the fetal alcohol syndrome, including abnormalities of the eyes, ears, mouth, face, cardiovascular system, CNS, and immune system. Maternal alcoholism may result in the DiGeorge syndrome either as the single causative factor or in conjunction with other as yet unknown teratogens.
D000437:Alcoholism / Q000150:complications; D002493:Central Nervous System Diseases / Q000209:etiology; D004062:DiGeorge Syndrome / Q000209:etiology / Q000473:pathology*; D004431:Ear, External / Q000002:abnormalities; D005124:Eye Abnormalities; D005145:Face / Q000002:abnormalities; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000209:etiology / Q000473:pathology*; D006330:Heart Defects, Congenital / Q000209:etiology; D006801:Humans; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes / Q000473:pathology*; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications