[Treatment with misonidazole and high voltage irradiation of xenotransplanted human carcinomas in nu/nu mice with thymic aplasia].
An investigation was conducted in order to determine the effect of combined high voltage irradiation and the sensitizing drug misonidazole (Ro-07-0582) on human gynecologic carcinomas transplanted into nu/nu mice with thymic aplasia. Two carcinomas of the endometrium, two carcinomas of the ovaries, and one carcinoma of the cervix were submitted to Co-60 irradiation with and without misonidazole. The tumor growth was compared to that of control groups. The dosage and fractionation of the high voltage irradiation (2 x 5 Gy/week, total dose 60 Gy) were adapted to clinical data. Misonidazole (1 mg/kg body weight) was administered by intraperitoneal injection 15 minutes before the irradiation. Compared with the control animals, the locally irradiated tumors showed a slower growth or even a regression. The administration of misonidazole, however, did not produce significant differences in our five cases. Some reasons for this absence of the radiosensitizing effect of misonidazole are briefly discussed.
D000818:Animals; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D005260:Female; D005833:Genital Neoplasms, Female / Q000532:radiotherapy*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D008920:Misonidazole / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D009593:Nitroimidazoles / Q000627:therapeutic use*; D010051:Ovarian Neoplasms / Q000532:radiotherapy; D011882:Radiotherapy, High-Energy; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy; D014594:Uterine Neoplasms / Q000532:radiotherapy
D003037:Cobalt Radioisotopes; D009593:Nitroimidazoles; D008920:Misonidazole
Misonidazol und Hochvoltbestrahlung an xenotransplantierten menschlichen Karzinomen auf thymusaplastischen nu/nu-Mäusen.