[Effect of pentoxifylline on the dissociation curve of oxyhemoglobin].
In 9 subjects with peripheral vascular insufficiencies the AA. have studied the behaviour of the oxyhaemoglobin dissociation curve before and after pentoxyphilline infusion. After this drug no variations were observed as it regards MCHC, 2-3-DPG and so on; however a positive correlation was found between 2-3-DPG and the Hill number. These results suggest that 2-3-DPG may influence the Hill number (which is the expression of the gradient of the oxyhaemoglobin dissociation curve) and therefore may interfere with O2 transport.
D000368:Aged; D001157:Arterial Occlusive Diseases / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D010108:Oxyhemoglobins / Q000378:metabolism*; D010431:Pentoxifylline / Q000494:pharmacology*; D013805:Theobromine / Q000031:analogs & derivatives*
D010108:Oxyhemoglobins; D013805:Theobromine; D010431:Pentoxifylline
Azione della pentossifillina sulla curva di dissociazione dell'ossiemoglobina.