Mebendazole concentrations in sheep plasma.
Formulated mebendazole was administered to sheep by intraruminal injection at dose rates of 12.5, 25, 50 or 100 mg/kg bodyweight. The concentrations of mebendazole and two major metabolites were measured by high-performance liquid chromatography in plasma taken at intervals up to 48 hours after treatment. At 12.5 mg/kg the peak plasma concentration was 0.22 +/- 0.03 microM mebendazole, rising to 0.76 +/- 0.04 microM at 100 mg/kg. Peak plasma concentrations occurred between nine and 24 hours for all dose rates and declined rapidly. Two major metabolites were detected; their concentrations exceeded that of mebendazole at all dose rates.
D000818:Animals; D001562:Benzimidazoles / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007700:Kinetics; D008297:Male; D008463:Mebendazole / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism; D012756:Sheep / Q000097:blood*; D013997:Time Factors
D001562:Benzimidazoles; D008463:Mebendazole