[Mechanism of low intensity ultrasound effect on mitochondria].
Ultrasound of 0,2 Wt/cm2 intensity affects the ionic transport across the mitochondrial membrane in vitro. In the presence of 1 mM EGTA in the incubation medium ultrasound slows down K+ exit into the external medium after the addition of an uncoupling agent (2,4-dinitrophenol). With the addition of 100 divided by 400 mM Ca2+ to the starting medium ultrasound makes the amount of Ca2+ absorbed by mitochondrial decrease and the rate of Ca2+/H+ electroneutral exchange increase. Without Ca2+ ultrasound does not influence the rate of coupled and 2,4-dinitrophenol uncoupled respiration and oxidative phosphorylation, i.e. does not produce strong functional changes.
D019297:2,4-Dinitrophenol; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D004140:Dinitrophenols / Q000494:pharmacology; D004533:Egtazic Acid / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007425:Intracellular Membranes / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014465:Ultrasonics
D004140:Dinitrophenols; D004533:Egtazic Acid; D019297:2,4-Dinitrophenol; D002118:Calcium
O mekhanizme deĭstviia ul'trazvuka nizkikh intensivnosteĭ na mitokhondrii.