Response of upper airway resistance to rebreathing in the rabbit. The interrupting effect of alpha-adrenergic blockers.
The response of upper airway resistance to rebreathing was studied in 20 rabbits. The upper airway decreased after rebreathing for 60 s, which induced hypercapnia and hypoxia. In the group injected with phentolamine mesylate, 2 mg/kg i.v., the decrease of the upper airway resistance was smaller than before administration. On the other hand, in the group injected with droperidol, 2 mg/kg i.v., this respiratory reflex was completely interrupted. The alpha-adrenergic function of this respiratory reflex is discussed.
D000403:Airway Resistance / Q000187:drug effects*; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood*; D002628:Chemoreceptor Cells / Q000187:drug effects; D004329:Droperidol / Q000494:pharmacology*; D009297:Nasal Mucosa / Q000098:blood supply; D010646:Phentolamine / Q000494:pharmacology*; D011817:Rabbits; D012018:Reflex / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D002245:Carbon Dioxide; D004329:Droperidol; D010646:Phentolamine