Effects of chronic salt intake on the capillaries in the cerebral cortex of spontaneously hypertensive rats (SHRs): an ultrastructural study.
Fine structural changes of capillaries in spontaneously hypertensive rats (SHRs) under the influence of 1% NaCl were studied. In SHRs (control), 30 weeks and older, capillaries showed deformed lumina, hypertrophy of endothelial cells and matrical alterations of mitochondria. Deformed capillary lumina, fibrosis in upper stream vessels and swelling of astrocytic processes were observed in the saline-treated SHRs. The significance of these findings is discussed.
D000818:Animals; D002196:Capillaries / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D002540:Cerebral Cortex / Q000098:blood supply*; D004727:Endothelium / Q000648:ultrastructure; D006965:Hyperplasia; D006973:Hypertension / Q000473:pathology*; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000494:pharmacology*
D012965:Sodium Chloride