Effects of chronic sino-aortic denervation in male rats on regional catecholamine levels and turnover and on neuroendocrine function.
A four week sino-aortic denervation produces an increase of adrenaline (A) turnover in the anterior but not the posterior hypothalamus and a selective reduction of dopamine stores in the anterior hypothalamus. Furthermore, the mean arterial blood pressure and heart rate are unchanged in conscious animals, and a selective increase in LH secretion is observed. The activation of a compensatory vasodepressor adrenergic mechanism in the anterior hypothalamus may in part be responsible for the maintenance of a normal mean arterial blood pressure after chronic sino-aortic denervation. The neurochemical changes in the hypothalamic area may also be related to the increase in LH secretion found after chronic sino-aortic denervation.
D000818:Animals; D001794:Blood Pressure; D001921:Brain / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D003714:Denervation; D004702:Endocrine Glands / Q000502:physiology*; D006728:Hormones / Q000097:blood; D007032:Hypothalamus, Anterior / Q000378:metabolism; D007034:Hypothalamus, Posterior / Q000378:metabolism; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012850:Sinus of Valsalva / Q000294:innervation*
D002395:Catecholamines; D006728:Hormones