title: Mechanism for the increase in solubility of deoxyhemoglobin S due to cross-linking the beta chains between lysine-82 beta 1 and lysine-82 beta 2.
mesh_terms: D019794:2,3-Diphosphoglycerate; D001241:Aspirin / Q000031:analogs & derivatives; D002263:Carboxyhemoglobin; D055598:Chemical Phenomena; D002621:Chemistry; D003432:Cross-Linking Reagents; D004163:Diphosphoglyceric Acids / Q000378:metabolism; D006441:Hemoglobin A / Q000302:isolation & purification; D006451:Hemoglobin, Sickle / Q000302:isolation & purification; D006801:Humans; D008239:Lysine; D011487:Protein Conformation; D012995:Solubility; D014961:X-Ray Diffraction
chemical_list: D003432:Cross-Linking Reagents; D004163:Diphosphoglyceric Acids; D006451:Hemoglobin, Sickle; C021630:bis(3,5-dibromosalicyl)fumarate; D019794:2,3-Diphosphoglycerate; C021631:bis(3,5-dibromosalicyl)succinate; C036858:bis(3,5-dibromosalicyl)glutarate; C036859:bis(3,5-dibromosalicyl)adipate; D006441:Hemoglobin A; D002263:Carboxyhemoglobin; D008239:Lysine; D001241:Aspirin