Studies on liver toxicants: influence of bromobenzene on hepatic microsomal drug-metabolizing enzymes in the hamster.
The effect of bromobenzene on hepatic microsomal drug-metabolizing enzymes was investigated in hamsters after oral applications of 1.5 and 3.0 g/kg body weight. After 1.5 g/kg a decrease of aminopyrine N-demethylase as well as an increase of hepatic hydroperoxide formation occurred. At 3.0 g/kg, most mixed-function oxidases were inhibited with the exception of ketamine N-demethylase, methylayapanine O-demethylase, and coumarin 7-hydroxylase. Hydroperoxide formation was increased but lipoperoxidation was reduced. Neither glucuronyltransferase I nor glucuronyltransferase II were affected by bromobenzene treatment.
D000818:Animals; D001969:Bromobenzenes / Q000494:pharmacology*; D006224:Cricetinae; D005260:Female; D008647:Mesocricetus; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism
D001969:Bromobenzenes; D006899:Mixed Function Oxygenases