title: Effects of a dopamine antagonist (metoclopramide) on the release of the adenohypophyseal hormones in amenorrhoeic patients with and without hyperprolactinaemia.
abstract: To obtain insight into the role of endogenous dopamine (DA) on the adenohypophyseal hormones release in amenorrhoeic women, responses of the adenohypophyseal hormones to a DA antagonist, metoclopramide (MCP), were evaluated in 4 normal women, in 9 normoprolactinaemic-amenorrhoeic patients, and in 7 hyperprolactinaemic-amenorrhoeic patients. The hyperprolactinaemic-amenorrhoeic patients were, in the majority, without a demonstrable microadenoma. Maximal net increase of prolactin (Prl) after MCP administration were lower (P less than 0.01) in hyperprolactinaemic patients compared with those seen in normal women or in normoprolactinaemic-amenorrhoeic patients. Administration of MCP resulted in significant elevation in serum FSH, LH and TSH in hyperprolactinaemic patients, but neither in normal women nor in normoprolactinaemic-amenorrhoeic patients. These findings suggest an increased dopaminergic inhibition of the release of TSH as well as FSH and LH in hyperprolactinaemic-amenorrhoeic patients.
mesh_terms: D000328:Adult; D000568:Amenorrhea / Q000097:blood*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008787:Metoclopramide / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood*; D011954:Receptors, Dopamine / Q000187:drug effects; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D013975:Thyroxine-Binding Proteins / Q000032:analysis
chemical_list: D011954:Receptors, Dopamine; D013975:Thyroxine-Binding Proteins; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D008787:Metoclopramide; D013974:Thyroxine