Prednisolone inhibits phagocytosis by polymorphonuclear leucocytes via steroid receptor mediated events.
Prednisolone, at concentrations between 2.78 x 10(-6) M (1 mug/ml) and 1.39 x 10(-8) M (5 x 10(-3) mug/ml) exerts an inhibitory effect on the phagocytosis of latex particles by normal human polymorphonuclear leucocytes in vitro as assessed by electron microscopical analysis. This inhibition appears to be receptor-mediated, as it is dependent upon RNA and protein synthesis and is glucocorticoid specific.
D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008863:Microspheres; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology / Q000648:ultrastructure; D010587:Phagocytosis / Q000187:drug effects*; D011239:Prednisolone / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011965:Receptors, Glucocorticoid / Q000187:drug effects*; D011987:Receptors, Steroid / Q000187:drug effects*
D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D003609:Dactinomycin; D003513:Cycloheximide; D011239:Prednisolone