title: Influence of the enteric surface coat on the unidirectional flux of acetamide across the wall of rat small intestine.
abstract: In vivo treatment of the jejunal mucosa with glycosidic enzymes seems to remove the enteric surface coat of the enterocyte. As a consequence, the mucosa-to-serosa unidirectional flux of acetamide increases remarkably. The glycocalyx probably represents a barrier to the diffusion of small hydrosoluble solutes.
mesh_terms: D000081:Acetamides / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D004058:Diffusion; D006023:Glycoproteins / Q000502:physiology*; D006026:Glycoside Hydrolases / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000187:drug effects; D007583:Jejunum / Q000378:metabolism*; D008297:Male; D011134:Polysaccharides / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000081:Acetamides; D006023:Glycoproteins; D011134:Polysaccharides; C030686:acetamide; D006026:Glycoside Hydrolases