Ultrastructural observations of cells at the interface of a biodegradable polymer: Polyglactin 910.
Transmission electron microscopy was used to study the ultrastructure of cells at the interface with an implanted biodegradable polymer, Polyglactin 910. Various stages of implantation were observed from 1 day to 63 days, when absorption of the polymer was essentially complete. Events occurring at the interface include initial adhesion of macrophages on the implant surface; phagocytosis of wound debris; and subsequent erosion, invasion, and phagocytosis of the polymer by macrophages and giant cells. A vascular perfusion technique for fixation of the polymer sites implanted in soft tissue is also described.
D000818:Animals; D001673:Biodegradation, Environmental; D005260:Female; D008264:Macrophages / Q000648:ultrastructure*; D008854:Microscopy, Electron; D010587:Phagocytosis; D011098:Polyglactin 910; D011108:Polymers; D019736:Prostheses and Implants; D051381:Rats; D013997:Time Factors
D011108:Polymers; D011098:Polyglactin 910