title: Changes in the liver copper content of Welsh mountain sheep after the injection of organic compounds of copper.
abstract: Subcutaneous injections of copper methionate, copper calcium edetate and copper oxyquinoline sulphonate were given to Welsh ewes in doses which provided amounts of copper ranging from 0 . 3 to 4 . 0 mg/kg bodyweight. The effect on the liver copper content was studied by analysing serial biopsy samples. The results suggest that a safer use of copper calcium edetate and a more efficacious use of copper oxyquinoline sulphate might be achieved by a reduction in the recommended dose of the former and an increase of the latter.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003300:Copper / Q000097:blood / Q000378:metabolism*; D004492:Edetic Acid / Q000494:pharmacology; D005260:Female; D007279:Injections, Subcutaneous / Q000662:veterinary; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008715:Methionine / Q000494:pharmacology; D015125:Oxyquinoline / Q000031:analogs & derivatives / Q000494:pharmacology; D012756:Sheep / Q000378:metabolism*
chemical_list: D015125:Oxyquinoline; D003300:Copper; C013053:8-hydroxyquinoline-5-sulfonic acid; D004492:Edetic Acid; D008715:Methionine