title: [Use of Drosophila in the detection of potentially carcinogenic agents].
abstract: The authors make a brief review of the value of using the fly Drosophila melanogaster to detect possible mutagenic and carcinogenic activities of chemicals. The study of the induction of chromosome X-linked recessive lethal mutations, translocations and chromosomal deletions, and non-disjunction phenomena in Drosophila is very useful to detect direct carcinogenic agents a well as precarcinogenic compounds that are ativated within the fly organism. The assays with Drosophila do not substitute, but follow and complement at a different biological level the assays made in batteries of tests employing bacteria.
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000032:analysis / Q000494:pharmacology*; D002875:Chromosomes / Q000187:drug effects; D004331:Drosophila melanogaster / Q000187:drug effects*; D005260:Female; D005804:Genes, Lethal; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology
chemical_list: D002273:Carcinogens; D009153:Mutagens
vernacular_title: Utilización de "Drosophila" en la detección de agentes potencialmente cancerígenos.