Effect of sex hormones on the activities of hepatic alcohol-metabolizing enzymes in male rats.
In mature male rats both estradiol administration as well as castration had a striking suppressive effect on the hepatic activity of the microsomal ethanol-oxidizing system, whereas alcohol dehydrogenase activity was increased under these experimental conditions. The castration effects on the activities of the alcohol-metabolizing enzymes could be completely prevented by the administration of testosterone. Therefore, these results indicate the sex-dependent nature of the hepatic microsomal ethanol-oxidizing system and alcohol dehydrogenase.
D000426:Alcohol Dehydrogenase; D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000818:Animals; D002369:Castration; D002374:Catalase / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology; D000431:Ethanol / Q000378:metabolism*; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D051381:Rats; D011917:Rats, Inbred Lew; D013347:Subcellular Fractions / Q000201:enzymology; D013739:Testosterone / Q000494:pharmacology
D012739:Gonadal Steroid Hormones; D000431:Ethanol; D013739:Testosterone; D004958:Estradiol; D003577:Cytochrome P-450 Enzyme System; D000429:Alcohol Oxidoreductases; D000426:Alcohol Dehydrogenase; D002374:Catalase; D009251:NADPH-Ferrihemoprotein Reductase