Effect of DI-n-pentyl phthalate treatment on testicular steroidogenic enzymes and cytochrome P-450 in the rat.
Treatment of young male rats with dipentyl phthalate (DPP) produced significant decreases in testicular cytochrome P-450, cytochrome P-450 dependent microsomal steroidogenic enzymes (17 alpha-hydroxylase, 17-20 lyase) and in the maximal binding of a natural substrate (progesterone) to testis microsomes. No effect was demonstrated by this compound on hepatic cytochrome P-450 content. Treatment of animals with a phthalate ester not causing testicular atrophy (diethyl phthalate; DEP) produced no significant changes in any of the parameters measured. This effect on the enzymes responsible for androgen production may be important as a mechanism of action involved in the development of phthalate-induced testicular damage.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis*; D008297:Male; D010795:Phthalic Acids / Q000633:toxicity*; D011374:Progesterone / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000187:drug effects* / Q000201:enzymology; D013739:Testosterone / Q000096:biosynthesis*; D015032:Zinc / Q000172:deficiency
D010795:Phthalic Acids; C034171:di-n-pentyl phthalate; D013739:Testosterone; D011374:Progesterone; D003577:Cytochrome P-450 Enzyme System; D015032:Zinc