title: Mutagenicity tests with astemizole in vitro and in vivo.
abstract: Possible induction of chromosomal aberrations and/or sister chromatid exchanges by astemizole was studied in vitro on human lymphocytes. In vivo chromosomal damage was assessed by a micronucleus test on rats and a dominant lethal test on both male and female mice. All these tests yielded negative results for astemizole so that is can be concluded that astemizole has no potential to induce chromosomal aberrations.
mesh_terms: D000818:Animals; D016589:Astemizole; D001562:Benzimidazoles / Q000633:toxicity*; D002467:Cell Nucleus / Q000187:drug effects; D002478:Cells, Cultured; D002875:Chromosomes / Q000187:drug effects; D005260:Female; D005799:Genes, Dominant / Q000187:drug effects; D005804:Genes, Lethal / Q000187:drug effects; D006801:Humans; D008099:Liver / Q000648:ultrastructure; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D009152:Mutagenicity Tests; D051381:Rats; D011919:Rats, Inbred Strains; D012854:Sister Chromatid Exchange; D013347:Subcellular Fractions / Q000378:metabolism
chemical_list: D001562:Benzimidazoles; D016589:Astemizole