Preliminary pharmacobiological study of new steroidal sapogenins.
The chemotherapeutic study of a limited series of steroidal sapogenins from several endemic species of the flora of the Canary Islands is presented here. On the whole, they possess a very weak antibacterial activity, a slight antifungal effect and one of them, vespertilin, displays interesting cytostatic activity (ID50 = 5 micrograms/ml). A pharmacodynamic screening carried out on this product mainly revealed very slight toxicity, antihistaminic activity and a light tranquilizing effect. The data obtained justify further research.
D000818:Animals; D001419:Bacteria / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D002415:Cats; D002455:Cell Division / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D006367:HeLa Cells; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010946:Plants, Medicinal; D051381:Rats; D012502:Sapogenins / Q000494:pharmacology* / Q000633:toxicity
D012502:Sapogenins