title: Effects of nutrition and environment on brain biochemistry and behavior.
abstract: A factorial design was used to explore the influence of malnutrition and environmental enrichment on brain development and adult behavior. Malnutrition in suckling rats was produced by restricting the intake of their dams to 40% of normal food consumption. Environment was enriched using combined preweaning handling and a postweaning complex environment treatment. Malnutrition produced lasting effects upon brain biochemical composition and behavior. The environmental manipulation had no ameliorative effect on the brain parameters measured but it had pronounced effects on behavior, decreasing latency to move in the open field and increasing some measures of activity while it enhanced passive-avoidance performance. There was little evidence for any interaction between the nutritional and environmental variables, but all trends were in the direction of the environmental treatment having more effect on the well-nourished rats.
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology*; D001921:Brain / Q000254:growth & development; D001923:Brain Chemistry; D004777:Environment; D005260:Female; D008297:Male; D008425:Maternal Behavior; D008892:Milk / Q000032:analysis; D009043:Motor Activity / Q000502:physiology; D009748:Nutrition Disorders / Q000503:physiopathology*; D009929:Organ Size; D010812:Physical Stimulation; D051381:Rats