A reaction-diffusion theory of morphogenesis with inherent pattern invariance under scale variations.
In the framework of reaction-diffusion theory we deal with the problem of pattern regulation in morphogenesis. A generic model is proposed where the kinetic terms follow constraints imposed by scale invariance considerations. These constraints allow a class of kinetic schemes to be formulated so that, starting with an initially homogeneous morphogen distribution in the field, a stable gradient is established of the form: S(chi,L) = Lpf(chi/L). Here L is the length of the morphogenetic field, chi is the position variable and f(chi/L) is some monotonic function of the relative distance. With this distribution a scale invariant gradient can be constructed which leads to pattern regulation. A linear stability analysis of the model permits the definition of the parameter values enabling the system to abandon the homogeneous state spontaneously. Simulations of the evolution of the system towards its final stable state result in approximate pattern invariance for different field lengths. The accuracy of this invariance is in agreement with some recent quantitative experimental findings in both developing and regenerating systems.
D000818:Animals; D002450:Cell Communication; D002463:Cell Membrane Permeability; D004058:Diffusion; D007700:Kinetics; D008954:Models, Biological; D009024:Morphogenesis