Polyamines: current review and their perspectives in neurosurgery.
A short review of polyamines and their possible clinical interest and applications in the field of brain neoplasms is presented. Dosage of CSF polyamines was proved to be useful in monitoring patients with medulloblastomas and others malignancies with meningeal involvement. Polyamines and their enzymes in neoplastic tissue may correlate to tumor growth. Inhibition of polyamines synthesis by drugs may be a possible way of slowing down tumor growth.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism*; D002528:Cerebellar Neoplasms / Q000134:cerebrospinal fluid; D000518:Eflornithine; D005910:Glioma / Q000134:cerebrospinal fluid; D006801:Humans; D007938:Leukemia / Q000134:cerebrospinal fluid; D008527:Medulloblastoma / Q000134:cerebrospinal fluid; D008577:Meningeal Neoplasms / Q000378:metabolism* / Q000556:secondary; D009952:Ornithine / Q000031:analogs & derivatives / Q000627:therapeutic use; D009955:Ornithine Decarboxylase / Q000378:metabolism; D011073:Polyamines / Q000032:analysis*; D011700:Putrescine / Q000134:cerebrospinal fluid; D051381:Rats; D013095:Spermidine / Q000134:cerebrospinal fluid
D000970:Antineoplastic Agents; D011073:Polyamines; D009952:Ornithine; D009955:Ornithine Decarboxylase; D013095:Spermidine; D011700:Putrescine; D000518:Eflornithine