Healing of experimental corneal wounds treated with topically applied retinoids.
We treated experimental corneal epithelial wounds in rabbits with topical retinoids. Treatment with 0.1% all-trans-retinoic acid three times per day resulted in a 21% increase in the healing rate compared to the control eyes. Treatment five times a day resulted in a 35% increase in healing rate. Treatment with topical retinoic acid also promoted corneal deturgescence. Retinyl palmitate, retinyl acetate, retinol, and 13-cis-retinoic acid had no effect on corneal wound healing. These data suggested that topically applied all-trans-retinoic acid may be effective in promoting corneal healing after surgery and in the treatment of persistent and recurring corneal epithelial defects.
D000287:Administration, Topical; D000818:Animals; D003315:Cornea / Q000601:surgery; D065306:Corneal Injuries; D004224:Diterpenes; D011817:Rabbits; D000084562:Retinyl Esters; D014212:Tretinoin / Q000008:administration & dosage*; D014801:Vitamin A / Q000008:administration & dosage* / Q000031:analogs & derivatives; D014945:Wound Healing / Q000187:drug effects*
D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate; C009166:retinol acetate; D014212:Tretinoin