title: A new tumor promoter, dihydroteleocidin B, enhances cell growth and the production of murine leukemia virus by fibroblasts.
abstract: The effects of tumor promoters on the expression of murine leukemia virus (MuLV) were studied in tissue culture. Dihydroteleocidin B, an indole alkaloid, recently found to be a tumor promoter, enhanced not only the production of Moloney MuLV (M-MuLV) by a mouse fibroblast cell line, C3H2K, persistently infected with M-MuLV, but also growth on the C3H2K cells. The production of infectious M-MuLV by M-MuLV-infected C3H2K cells that had been treated with dihydroteleocidin B for 1-7 days was four or five times higher than that of control cells. C3H2K cells grew faster and became stationary at higher cell densities in the presence of dihydroteleocidin B than in its absence. The tumor-promoting phorbol ester phorbol-12, 13-didecanoate and 12-O-tetradecanoylphorbol-13-acetate also enhanced the production of M-MuLV, but their effects were not so strong as that of dihydroteleocidin B. These tumor promoters, however, did not induce production of endogenous MuLV in C3H2K or K-BALB cells.
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D002273:Carcinogens; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D005347:Fibroblasts / Q000382:microbiology*; D008235:Lyngbya Toxins; D051379:Mice; D008979:Moloney murine leukemia virus / Q000187:drug effects*; D013997:Time Factors; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000470:Alkaloids; D002273:Carcinogens; D008235:Lyngbya Toxins; C022229:dihydroteleocidin B