Lethality of pentazocine and tripelennamine combinations in mice housed individually and in groups.
Lethality of 80 mg/kg pentazocine alone; 40 mg/kg tripelennamine alone; 20 mg/kg tripelennamine in combination with 40, 60, and 80 mg/kg pentazocine; and 40 mg/kg tripelennamine in combination with 10, 20, and 40 mg/kg pentazocine was determined in mice housed individually and in groups. Results indicate that the lethality of pentazocine and tripelennamine combinations in mice is (1) dose-dependent, (2) potentiated relative to either drug alone, and (3) greater in group-housed than in individually-housed animals.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D010423:Pentazocine / Q000633:toxicity*; D012934:Social Isolation; D014309:Tripelennamine / Q000633:toxicity*
D014309:Tripelennamine; D010423:Pentazocine