Mutant monoclonal antibodies with alterations in biological functions.
Somatic cell mutants with deletions in the immunoglobulin constant region were isolated from an IgG(2b) Ar-binding hybridoma. Rat anti-mouse immunoglobulins were used to identify the sites of the deletions. The mutant monoclonal antibodies differ from the parental molecule in their assembly states and are defective in various immunoglobulin activities, making them potentially more useful reagents.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000235:genetics*; D002460:Cell Line; D002872:Chromosome Deletion; D006825:Hybridomas / Q000276:immunology; D007127:Immunoglobulin Constant Regions / Q000235:genetics; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D051379:Mice; D009154:Mutation; D009194:Myeloma Proteins / Q000235:genetics; D051381:Rats; D010132:p-Azobenzenearsonate / Q000378:metabolism
D000911:Antibodies, Monoclonal; D007127:Immunoglobulin Constant Regions; D007143:Immunoglobulin Heavy Chains; D009194:Myeloma Proteins; D010132:p-Azobenzenearsonate