Histoenzymatic alterations in kidney catalase activity following hormonal treatment of Syrian hamsters.
Diethylstilbestrol (DES) treatment decreases hamster kidney catalase activity and at the same time induces renal adenocarcinomas. Subsequent progesterone treatment reverses the tumorigenic effect of DES and restores catalytic activity. Our results suggest that the reduction in catalase activity with estrogen treatment may be related to the process of carcinogenicity.
D000818:Animals; D002374:Catalase / Q000378:metabolism*; D006224:Cricetinae; D004054:Diethylstilbestrol / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008647:Mesocricetus; D011374:Progesterone / Q000494:pharmacology*
D011374:Progesterone; D004054:Diethylstilbestrol; D002374:Catalase