[Effect of the male sex hormone and its 5 alpha-reduced metabolites on the function of the thyroid in vivo and in vitro].
The administration of testosterone propionate, dihydrotestosterone and androstandiol to male rats was followed by different changes in thyroid function. Testosterone propionate exerted a stimulating effect, whereas its metabolites induced marked depression of thyroid functional activity in the experiments in vivo. In vitro both sex hormones and 5-alpha-reduced metabolites inhibited radioactive iodine absorption by rat thyroid slices and human thyrotoxic struma. The data demonstrate that testosterone may produce a direct effect on the thyroid without the hypophysis.
D015114:Androstenediol / Q000494:pharmacology*; D000734:Androstenediols / Q000494:pharmacology*; D000818:Animals; D013196:Dihydrotestosterone / Q000494:pharmacology*; D006801:Humans; D007455:Iodine / Q000378:metabolism; D008297:Male; D009924:Organ Culture Techniques; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000494:pharmacology*; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*
D000734:Androstenediols; D013196:Dihydrotestosterone; D013739:Testosterone; D015114:Androstenediol; D007455:Iodine
Vliianie muzhskogo polovogo gormona i ego 5 alpha-vosstanovlennykh metabolitov na funktsional'noe sostoianie shchitovidnoĭ zhelezy in vivo i in vitro.