An early effect of testosterone propionate upon hypothalamic function in the neonatal rat.
Rats treated neonatally with testosterone propionate exhibit a reduced uterine growth response to estradiol administration prepubertally. This androgen-induced impairment is the consequence of developmental effects on both the ovary and the hypothalamic-pituitary complex, although the latter is the more sensitive.
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology*; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects* / Q000502:physiology / Q000637:transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000494:pharmacology*; D014599:Uterus / Q000254:growth & development
D013739:Testosterone; D004958:Estradiol