Inducible DNA repair enzymes involved in the adaptive response to alkylating agents.
Two different DNA repair enzymes are induced in E. coli by methylating agents: a methyltransferase acting on 0(6)-methylguanine residues, and a DNA glycosylate for N-methylated purines. The properties of the homogeneous methyltransferase are described.
D000477:Alkylating Agents / Q000494:pharmacology*; D045647:DNA Glycosylases; D004260:DNA Repair; D004926:Escherichia coli / Q000201:enzymology*; D008745:Methylation; D008780:Methyltransferases / Q000378:metabolism*; D008970:Molecular Weight; D009699:N-Glycosyl Hydrolases / Q000378:metabolism*; D019853:O(6)-Methylguanine-DNA Methyltransferase
D000477:Alkylating Agents; D008780:Methyltransferases; D019853:O(6)-Methylguanine-DNA Methyltransferase; D045647:DNA Glycosylases; D009699:N-Glycosyl Hydrolases; C076131:DNA-3-methyladenine glycosidase II