[Regrowth in post-antibiotic period. A new approach based on the early response of the growth curve (author's transl)].
Growth curve studies (MS-2 Abbott) of Escherichia coli and Pseudomonas aeruginosa cultures submitted to different beta-lactams concentrations showed that a) the maximal values of residual growth (MVRG) observed in the first hours of contact between antibiotic and bacteria was either concentration dependent (carbenicillin, ticarcillin, moxalactam, ceftazidime, cefsulodin against Escherichia coli) or concentration independent (azlocillin, mezlocillin, piperacillin against E. coli and all beta-lactams against P. aeruginosa) ; b) a relationship was found between MVRG and lag of regrowth in the postantibiotic period ; c) the MVRG independent of antibiotic concentration was associated with filament formation. This observation may contribute to athe best choice of the mode of administration of an antibiotic in therapeutic field (peak level or plateau).
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development*; D003720:Densitometry; D004926:Escherichia coli / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000254:growth & development; D013997:Time Factors; D001618:beta-Lactamases / Q000378:metabolism; D047090:beta-Lactams / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D001618:beta-Lactamases
Vitesse de recroissance bactérienne en période post-antibiotique. Tentative de prévision basée sur l'étude de la réponse précoce des courbes de croissance.