Cardiopulmonary effects of butorphanol tartrate in dogs.
The effects of butorphanol given (IV) at dose levels of 0.1 and 0.4 mg/kg were evaluated in conscious dogs, n = 5 for each dose. Mild sedation occurred, though it was greater in dogs given the larger dose. Two dogs in each group panted, but PaCO2 was not significantly changed. Small, but significant, decreases in arterial blood pressure, heart rate, and PaO2 occurred (P less than 0.05). Base excess developed a negative trend. The PCV and total protein decreased slightly in dogs given the smaller dose, but were unchanged with the larger dose. Plasma glucose remained within acceptable limits.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002077:Butorphanol / Q000031:analogs & derivatives / Q000494:pharmacology*; D004285:Dogs / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D009019:Morphinans / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D012119:Respiration / Q000187:drug effects
D009019:Morphinans; D002077:Butorphanol; D010100:Oxygen