[Capacity of diphosphonates to bind calcium and their effect on the osmotic permeability of the frog bladder wall].
Like EDTA, diphosphonates increase permeability of the frog urinary bladder wall for water osmotic gradient. Their effect is proportional to the stability of their binding with calcium ions. The efficacy of diphosphonates falls upon pH decline. The results indicate the significance of Ca binding in cells and membrane action of diphosphonates.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004164:Diphosphonates / Q000378:metabolism* / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D009995:Osmosis / Q000187:drug effects; D011896:Rana temporaria; D001743:Urinary Bladder / Q000187:drug effects* / Q000378:metabolism; D014867:Water / Q000378:metabolism
D004164:Diphosphonates; D014867:Water; D004492:Edetic Acid; D002118:Calcium
Sposobnost' difosfonatov sviazyvat' kal'tsiĭ i ikh vliianie na osmoticheskuiu pronitsaemost' stenki mochevogo puzyria liagushki.