Human Ia molecules carrying DC1 or BR4X7 determinants are not homologous to murine I-E molecules.
An anti-I-Ek alloantiserum was shown to react with purified human Ia preparation. All Ia preparations tested were actively bound irrespective of their HLA-DR phenotypes. However, from a quantitative point of view, DR7 molecules were significantly less reactive. No reaction was observed with isolated Ia subunits. Only molecules carrying DR determinants, but not those carrying either DC1 or BR4X7 determinants, were bound.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001666:Binding Sites, Antibody; D005802:Genes, MHC Class II; D006684:HLA-DR Antigens; D006649:Histocompatibility Antigens / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D051379:Mice; D008805:Mice, Inbred A; D011817:Rabbits
D000961:Antilymphocyte Serum; D006684:HLA-DR Antigens; D006649:Histocompatibility Antigens; D000949:Histocompatibility Antigens Class II; C024138:I-E-antigen