Corn oil-induced changes in the dorsal root ganglia of rats.
The effects of corn oil on rat dorsal root ganglia (DRG) were examined by both light and electron microscopy. Rats were fed corn oil via intubation 5 days per week for 7 weeks. No apparent morphological lesion was observed in the DRG by means of light microscopic examination. However, various cytological changes were revealed by electron microscopy. The most prominent change was the extensive and severe edematous condition in the interstitial space. After 7 weeks of treatment, the interstitial space between neurons and nerve fibers was distended by proteinaceous edematous fluid and collagen fibers. Distention of the intercellular space between the ganglion neurons and their surrounding satellite cell sheaths also occurred. Proliferation of the supporting cells, especially the satellite cells and Schwann cells, producing long and complex networks of cellular processes in the distended interstitial space was also evident. It is believed that chronic ingestion of corn oil by rats has an adverse effect on the endothelial system leading to an increased fluid permeability and edematous condition.
D000818:Animals; D005727:Ganglia, Spinal / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D008041:Linoleic Acids / Q000009:adverse effects; D008297:Male; D008854:Microscopy, Electron; D009821:Oils / Q000009:adverse effects*; D051381:Rats; D003313:Zea mays
D008041:Linoleic Acids; D009821:Oils