Implanted cochlear prosthesis analogue in primates.
Electronic cochlear prostheses are currently being implanted in the profoundly deaf. Little, however, is known about the biologic effects of electrical stimulation of the auditory system. To study some effects of intracochlear electrical stimulation in monkeys, a totally implantable device that produces a constant current similar to that produced by devices now used in human implantation was designed and miniaturized. This paper reports on the characteristics of the device and a pilot project designed to test it in vivo. The feasibility of primate implantation and behavioral observation, as well as histopathologic study, was also determined. The device was implanted in each of two Macacca nemestrina monkeys, which were then observed. One monkey was killed and the implanted cochlea studied with scanning electron microscopy. Evidence of osteogenesis of the scala tympani was found.
D000669:Amplifiers, Electronic; D000818:Animals; D001522:Behavior, Animal; D003051:Cochlea / Q000648:ultrastructure*; D003054:Cochlear Implants / Q000295:instrumentation; D004867:Equipment Design; D008251:Macaca / Q000601:surgery*; D008254:Macaca nemestrina / Q000601:surgery*; D008297:Male; D008855:Microscopy, Electron, Scanning; D010865:Pilot Projects