Antibody-induced cell-cycle synchrony.
Synergism between specific antibodies and cytotoxic drugs in killing tumor cells is an established phenomenon. When cells grown in a suspension culture are treated with antibody, a subsequent increase in susceptibility to cytosine arabinoside has been shown to be due to the induction of cell-cycle synchrony. This observation may lead to a novel way of investigating cell-cycle-dependent processes and also an aspect of tumor-antibody interactions that is not generally recognized.
D000818:Animals; D000912:Antibodies, Neoplasm; D002453:Cell Cycle; D002478:Cells, Cultured; D003561:Cytarabine / Q000008:administration & dosage*; D007167:Immunotherapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000628:therapy*
D000912:Antibodies, Neoplasm; D003561:Cytarabine