title: R-wave amplitude change during aerobic exercise in hypertensive adolescents after treatment.
abstract: This study attempts to determine whether the blunted reduction in R-wave amplitude during progressive aerobic exercise observed in adolescents with systemic hypertension could be altered by pharmacologic therapy to reduce blood pressure. Twenty-nine hypertensive adolescents were randomly assigned to treatment with either a diuretic, hydrochlorothiazide, or a centrally acting agent, clonidine. After 16 weeks of therapy, casual blood pressure was significantly reduced in both groups. Repeat exercise stress testing on therapy demonstrated a significant change in R-wave response. In both treatment groups the change in R-wave amplitude during exercise corresponded with the R-wave response pattern observed in normotensive control subjects. These observations indicate that the altered R-wave amplitude response to exercise observed in young hypertensive subjects is reversible and suggest that the altered R-wave response before treatment is related to a higher vascular resistance.
mesh_terms: D000293:Adolescent; D000328:Adult; D000332:Aerobiosis; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000627:therapeutic use; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006973:Hypertension / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male
chemical_list: D006852:Hydrochlorothiazide; D003000:Clonidine