Killing of blood-stage murine malaria parasites by hydrogen peroxide.
Both nonlethal Plasmodium yoelii and lethal Plasmodium berghei were killed in vitro by hydrogen peroxide at concentrations as low as 10(-5) M. Higher concentrations were required in the presence of added normal erythrocytes. Injection of hydrogen peroxide in vivo significantly reduced P. yoelii parasitemia but had less effect on P. berghei.
D000818:Animals; D001769:Blood / Q000469:parasitology; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects; D006861:Hydrogen Peroxide / Q000378:metabolism / Q000494:pharmacology*; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D010961:Plasmodium / Q000187:drug effects*
D006861:Hydrogen Peroxide