Quantitation of tumor growth in the ears of mice.
Transplantation of ascitic P-815 mastocytoma cells intradermally in the ears of syngeneic DBA/2J mice allows a simple and precise quantitation of tumor growth by ear swelling. Tumor growth was retarded and then arrested in allogeneic DBA/1J mice, whereas syngeneic hosts died as a result of tumor dissemination in draining lymph nodes, liver and spleen.
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000473:pathology; D004306:Dose-Response Relationship, Immunologic; D004428:Ear Neoplasms / Q000503:physiopathology*; D005260:Female; D006084:Graft Rejection; D006968:Hypersensitivity, Delayed / Q000175:diagnosis; D012515:Mast-Cell Sarcoma / Q000473:pathology / Q000503:physiopathology*; D051379:Mice; D008811:Mice, Inbred DBA; D008937:Mitomycins / Q000494:pharmacology; D009368:Neoplasm Transplantation
D008937:Mitomycins