Sodium retention and cortisol (hydrocortisone) suppression caused by dexamethasone and triamcinolone in equids.
Three ponies and 1 horse were bilaterally adrenalectomized (BADX). The initial hypoadrenal episode after BADX was reversed with 20 mg of dexamethasone (DXM) IM (n = 2) or 20 mg of triamcinolone (TMC) IM (n = 2). Nine hypoadrenal crises were reversed with 20 mg of DXM given IM (n = 4) or 20 mg of TMC given IM (n = 5). Sodium and chloride retention and potassium excretion were documented based on changes in serum electrolytes and urinary excretion. Eight intact adult horses were randomly assigned to 2 groups to study the effects of a single IM injection of DXM (0.044 mg/kg of body weight) or TMC (0.044 mg/kg). Cortisol (hydrocortisone) suppression was found to be maximal (nondetectable amounts of cortisol) by 12 hours in both groups. Cortisol was again detectable in the DXM group at 24 hours after injection and was at pretreatment values at 168 hours. Cortisol was not detectable in the TMC group for 192 hours and did not reach pretreatment values until 336 hours. The duration of the gluconeogenic effect was compared with the duration of cortisol suppression exerted by DXM and TMC in these intact animals. Assuming that the decrease in plasma glucose coincides with the decrease in glucocorticoid activity of the respective steroid, a relative hypoadrenocortical state was found in the animals treated with DXM between the 2nd and 7th day after treatment, whereas this state occurred between the 6th and 14th day after treatment with TMC.
D000315:Adrenalectomy / Q000662:veterinary*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D003864:Depression, Chemical; D003907:Dexamethasone / Q000494:pharmacology*; D004573:Electrolytes / Q000378:metabolism; D005943:Gluconeogenesis; D006736:Horses / Q000378:metabolism*; D006854:Hydrocortisone / Q000097:blood*; D012964:Sodium / Q000378:metabolism*; D014221:Triamcinolone / Q000494:pharmacology*
D001786:Blood Glucose; D004573:Electrolytes; D014221:Triamcinolone; D003907:Dexamethasone; D012964:Sodium; D003404:Creatinine; D006854:Hydrocortisone