title: The genetics of the sixth and seventh components of complement in the dog: polymorphism, linkage, locus duplication, and silent alleles.
abstract: The complement components C6 and C7 exhibit genetic polymorphism in the domestic dog. In the case of C6, there is a single locus with a null allele and two structural alleles; in the case of C7, there are two linked loci, each with three structural alleles. There is a null allele or locus deletion at one of these loci. In all cases, inheritance is autosomal and codominant. The C7 loci are closely linked to each other and to C6. This complex is not close to the dog major histocompatibility complex (MHC) locus.
mesh_terms: D000483:Alleles; D000818:Animals; D003183:Complement C6 / Q000235:genetics*; D003184:Complement C7 / Q000235:genetics*; D003433:Crosses, Genetic; D004285:Dogs; D005260:Female; D008040:Genetic Linkage; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D003183:Complement C6; D003184:Complement C7