title: Plasma neurotensin release and gastric emptying in the dumping syndrome.
abstract: Seventy-three patients were studied after ingesting a liquid glucose meal, tagged with 113Indium. Nineteen of these patients were awaiting surgery for their duodenal ulcer, while 54 were studied postoperatively, 25 of whom experienced troublesome postprandial (dumping) symptoms in their daily lives. The radioactive marker emptied significantly faster in the symptomatic patients than in the symptomfree, pre and post-operative groups (initial emptying rate 3.45 +/- 0.23, compared with 1.16 +/- 0.19 and 1.27 +/- 0.15% fall in counts/min respectively; p less than 0.01). Initial (20 min) rises in the plasma concentrations of neurotensin-like immunoreactivity measured during the test correlated significantly with the rate of gastric emptying in all patients, being greatest in patients with dumping symptoms. Physiological concentrations of neurotensin have been shown to delay gastric emptying. The excessive rise in plasma neurotensin-like immunoreactivity in patients with dumping symptoms, presumably occurring as a result of the rapid passage of nutrients to the neurotensin-rich ileum, may possibly have a compensatory role in slowing further emptying from the stomach.
mesh_terms: D003201:Computers; D004377:Dumping Syndrome / Q000097:blood / Q000503:physiopathology*; D004381:Duodenal Ulcer / Q000601:surgery; D005746:Gastric Emptying; D006801:Humans; D009496:Neurotensin / Q000097:blood*
chemical_list: D009496:Neurotensin