title: Role of lipid peroxidation in tissue injury after hepatic ischemia.
abstract: Ischemia and anoxia are associated with decreased concentrations of cellular antioxidants. The hypothesis that recirculation of oxygenated blood to previously ischemic tissue may result in enhanced free-radical reactions leading to lipid peroxidation and tissue damage was investigated. Elevated hepatic conjugated diene concentrations were detected 60 min after treatment of rats with carbon tetrachloride, a positive control, but were not found after 90 min ischemia or at 5 or 60 min after reperfusion of ischemic tissue. These findings suggest that lipid peroxidation may not be an early event in ischemia-induced necrosis but do not rule out a role of other free-radical reactions in the pathogenesis of ischemic necrosis.
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D005260:Female; D006499:Hepatic Artery / Q000502:physiology; D007511:Ischemia / Q000378:metabolism / Q000473:pathology*; D008026:Ligation; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000098:blood supply*; D008862:Microsomes, Liver / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D009336:Necrosis; D011090:Polyenes / Q000378:metabolism; D011169:Portal Vein / Q000502:physiology; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D008054:Lipid Peroxides; D011090:Polyenes; D011506:Proteins; D000410:Alanine Transaminase