Matrix antigens in allografts. II. The cell-mediated response.
The cell-mediated response of link proteins (LP) and proteoglycan monomer (PG), the matrix antigens of articular cartilage, was investigated in the late rejections of joint allografts in dogs. Cell-mediated immunity was present as determined by the Macrophage Inhibition Test and by skin sensitivity, which was present at 26 and 52 weeks after allografting. The Migration Inhibition was 70% at 12 weeks, and 50% at 26 and 52 weeks after allografting. Skin sensitivity was present after these intervals. The synovium was hypercellular, had the appearance of a pannus, and invaded and destroyed the graft.
D000818:Animals; D000941:Antigens / Q000276:immunology*; D002358:Cartilage, Articular / Q000166:cytology / Q000276:immunology* / Q000637:transplantation; D002464:Cell Migration Inhibition; D004285:Dogs; D006968:Hypersensitivity, Delayed; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D014181:Transplantation Immunology
D000941:Antigens