HLA haplotype study of 53 juvenile insulin-dependent diabetic (I.D.D.) families.
R4 heterozygotes was observed. By contrast, the observed frequency of patients homozygous for DR3 or DR4 was not increased, but even slightly decreased. The data support a model of inheritance comprising at least two closely linked specifically "diabetic" loci (most of the time marked by B18, BfF1, DR3 and B15, BfS, DR4) and a non-specifically "diabetic" haplotype favouring auto-immunisation (most of the time marked by B8, BfS, DR3). This model is discussed in the light of the presented data and of those of the literature.
D000293:Adolescent; D000328:Adult; D000483:Alleles; D002648:Child; D002874:Chromosome Mapping; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency; D005802:Genes, MHC Class II; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D006238:Haploidy; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D010297:Paris
D006680:HLA Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D007328:Insulin