title: Gas chromatographic analysis of ketamine and norketamine in plasma and urine: nitrogen-sensitive detection.
abstract: A sensitive gas chromatographic method for quantitative analysis of ketamine and norketamine in human and animal biological fluids is described. The nitrogen-sensitive detection procedure used is more stable than electron-capture detection and reduced analysis time. The method used bromo-ketamine as an internal standard for quantitation and is linear from 10-25,000 ng/ml. No interferences were shown with drugs commonly associated with cardiac surgery with cardiopulmonary by-pass. This assay is sensitive, specific, using either native or derivatized drugs and can be used for routine analysis of ketamine and norketamine in plasma or urine.
mesh_terms: D000328:Adult; D000818:Animals; D002648:Child; D002849:Chromatography, Gas; D004285:Dogs; D000882:Haplorhini; D006801:Humans; D007649:Ketamine / Q000031:analogs & derivatives* / Q000032:analysis* / Q000097:blood / Q000378:metabolism / Q000652:urine; D007700:Kinetics; D009584:Nitrogen
chemical_list: D007649:Ketamine; D009584:Nitrogen; C033419:norketamine