[Excitatory effects of 2 peptides on rat cortical neurons: laminar distribution and correlation with the effect of acetylcholine].
The most frequent effect observed following iontophoretic application of cholecystokinin or vasoactive intestinal polypeptide on Rat SI cortical neurons was an excitation. Most of the peptide-sensitive neurons were located in infragranular layers of the cortex. In most instances these neurons could also be excited by acetylcholine. These results suggest that some neuropeptides and acetylcholine might share common mechanisms of action on cortical neurons.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects*; D002766:Cholecystokinin / Q000494:pharmacology*; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D005768:Gastrointestinal Hormones; D014660:Vasoactive Intestinal Peptide; D002766:Cholecystokinin; D000109:Acetylcholine
Effets excitateurs de deux peptides sur les neurones corticaux du rat: distribution laminaire et corrélation avec les effets de l'acétylcholine.