Multifocal brain sites for apomorphine-induced circling and other stereotyped motor behaviour in the 6-hydroxydopamine-lesioned rat.
Rats pretreated with 6-hydroxydopamine (6-OHDA, 8 micrograms in 4 microliters) in one medial forebrain bundle exhibited an assortment of stereotyped activities and pronounced circling towards the unlesioned side when apomorphine was administered either subcutaneously (0.5 mg/kg), or by discrete stereotaxic injection (5 micrograms in 0.2 microliter) into the caudate nucleus, nucleus accumbens, amygdala, lateral habenula, ventromedial thalamus, substantia nigra zona reticulata, periaqueductal grey or superior colliculus (but not a variety of other areas) ipsilateral to the lesion. These rotational responses were absent in unlesioned animals and, where tested, were attenuated by intraperitoneal haloperidol (0.5 mg/kg). It is suggested that multiple brain sites become sensitive to apomorphine following dopamine depletion by 6-OHDA.
D000679:Amygdala / Q000187:drug effects; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D002421:Caudate Nucleus / Q000187:drug effects; D005625:Frontal Lobe / Q000187:drug effects; D006801:Humans; D006892:Hydroxydopamines / Q000633:toxicity*; D007031:Hypothalamus / Q000187:drug effects; D008297:Male; D008473:Median Eminence / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects*; D016627:Oxidopamine; D010487:Periaqueductal Gray / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects*; D013378:Substantia Nigra / Q000187:drug effects; D013787:Thalamic Nuclei / Q000187:drug effects
D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D016627:Oxidopamine; D001058:Apomorphine