title: Effect of diltiazem on left ventricular isovolumic relaxation time in patients with hypertrophic cardiomyopathy.
abstract: The effect of diltiazem on left ventricular isovolumic relaxation time was examined in 11 patients with hypertrophic obstructive and non-obstructive cardiomyopathy in a combined study using phonocardiograms and echocardiograms. Five to 10 min after intravenous injection of diltiazem (0.2 mg/kg, body weight), a prolonged isovolumic left ventricular relaxation time, which was measured from aortic component of the second heart sound to the mitral opening on the echocardiogram, decreased from 63.1 +/- 26.0 to 46.9 +/- 28.0 msec (p less than 0.01). This study suggests that diltiazem, one of the calcium blocking agents, may ameliorate the impaired left ventricular diastolic function in patients with hypertrophic cardiomyopathy.
mesh_terms: D000293:Adolescent; D000328:Adult; D001552:Benzazepines / Q000494:pharmacology*; D009202:Cardiomyopathies / Q000503:physiopathology*; D004110:Diltiazem / Q000494:pharmacology*; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*
chemical_list: D001552:Benzazepines; D004110:Diltiazem