[Statistics on 123 children with febrile convulsions from 1976 to 1981 with possible advantages of continuous prophylaxis with valproic acid and/or phenobarbital].
All children (6 months to 5 years of age) presenting with febrile seizures have been followed for 3-5 years. Analysis of the data of 123 children gave the following results: -in 20 cases the duration of the convulsions was longer than 20 minutes; -males were prevalent (60,2%) and characterised by a longer duration of convulsive manifestations (20,2% of cases); -valproic acid (20-30 mg/kg/die) or phenobarbital (3-5 mg/kg/die) prophylaxis for a minimum of I year protect against recurrence of convulsions (26,6% of new episodes in non treated vs 10,2% in treated patients); -irrespective of drug prophylaxis, recurrence is minimal and approaches zero, when the first episode occurs in children older than 3 years; -only one case (0,8%) had recurrence not associated with fever, during valproic acid treatment two years after the first episode.
D000367:Age Factors; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use*; D012008:Recurrence; D003294:Seizures, Febrile / Q000188:drug therapy*; D014635:Valproic Acid / Q000627:therapeutic use*
D014635:Valproic Acid; D010634:Phenobarbital
Rilievi statistici condotti dal 1976 al 1981 sulle convulsioni febbrili in 123 bambini e sui possibili vantaggi della profilassi continua con dipropilacetato e/o fenobarbital.