title: Moist wound healing under a vapor permeable membrane.
abstract: Ten ambulatory patients with unilateral and eight with bilateral ulcers of various etiologies were studied to determine the effects of keeping a wound bed moist under a water vapor and oxygen permeable membrane (VPM). In the bilateral group, VPM healing was compared with a debriding enzyme ointment and 10% benzoyl peroxide in the same patient. The faster healing rate with VPM was compared to the healing rate with control substances by the paired t test, with significance at less than 0.05 level. In the unilateral group two patients with ulcers to bone or joint capsule and one patient who had failed grafting healed without surgery. Two patients failed to heal with the VPM. All healing occurred in the face of gross bacterial contamination. Three patients treated with VPM developed cellulitis. Wound healing under a vapor permeable membrane occurs with an increase of the average healing rate by a factor of 2.6 when compared to control substances in ambulatory patients.
mesh_terms: D001585:Benzoyl Peroxide / Q000627:therapeutic use; D005533:Foot Dermatoses / Q000628:therapy; D006801:Humans; D011140:Polyurethanes; D003668:Pressure Ulcer / Q000628:therapy; D012883:Skin Ulcer / Q000628:therapy*; D014945:Wound Healing / Q000187:drug effects; D014946:Wound Infection / Q000628:therapy
chemical_list: C027324:Opsiture; D011140:Polyurethanes; D001585:Benzoyl Peroxide