Psychophysiological measurements after oral atropine in man.
Eight healthy male volunteers received double-blind and cross-over placebo or atropine (0.85 or 1.7 mg). Various physiological, psychological and psychomotor measurements were made before a single oral dose and 1, 2 and 4 hrs after it. Typical peripheral antimuscarinic effects were found after atropine, maximally at 2-4 hrs. Atropine impaired flicker recognition, reaction time, short-time, short-term memory, coordination, time anticipation and standing steadiness. The CNS-impairment was maximal at 1 hr and dose-related in most instances.
D000328:Adult; D001285:Atropine / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005425:Flicker Fusion; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects*; D011680:Pupil / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D014785:Vision, Ocular / Q000187:drug effects
D001285:Atropine