[Use of carnitine for stimulation of the growth and development of the mouse brain in undernourishment in early postnatal ontogeny].
The authors studied the possibilities of using carnitine for stimulation of the mouse brain development under malnutrition in the early postnatal ontogenesis. The results indicate that addition of carnitine to the diet during food rehabilitation stimulates the growth of the body and brain mass, increases the neocortex, hippocamp, cerebellum and the size of neuronal bodies in these structures, removes the effect of retarding the growth of neuronal processes and noticeably decreases the rate of dystrophic changes in the brain structures under study. Thus, the disturbances of the mouse brain development caused by malnutrition are completely eliminated after the animals are fed a full-value diet containing carnitine.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000254:growth & development; D002331:Carnitine / Q000627:therapeutic use*; D004032:Diet; D004353:Drug Evaluation, Preclinical; D051379:Mice; D008808:Mice, Inbred CBA; D011502:Protein-Energy Malnutrition / Q000178:diet therapy* / Q000503:physiopathology; D013268:Stimulation, Chemical
D002331:Carnitine
Primenenie karnitina dlia stimuliatsii rosta i razvitiia golovnogo mozga mysheĭ pri nedoedanii v rannem postnatal'nom ontogeneze.