[Effect of hypothermia and anti-angina preparations with malonate-like action on myocardial glycolysis and oxidative phosphorylation].
It has been discovered that hypothermia under 20 degrees C produces no effect on the reactions of anaerobic glycolysis and lactate level in the rat and dog myocardium during ischemia and anoxia. At the same time hypothermia reduces 8-10-fold the rate of free and conjugated mitochondrial respiration, which is similar to the malonate-like action of a number of antianginal drugs. Based on the fact that hypothermia protects the tissues from ischemic lesions it is concluded that inhibition of mitochondrial respiration with the drugs having a malonate-like action or with other mechanisms is to also protect the myocardium at early times of acute ischemia.
D000787:Angina Pectoris / Q000378:metabolism / Q000628:therapy*; D000818:Animals; D003327:Coronary Disease / Q000378:metabolism / Q000628:therapy; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D006019:Glycolysis / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D007036:Hypothermia, Induced; D000860:Hypoxia / Q000378:metabolism / Q000628:therapy; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008314:Malonates / Q000627:therapeutic use*; D009206:Myocardium / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010208:Papaverine / Q000627:therapeutic use
D007773:Lactates; D008314:Malonates; D019344:Lactic Acid; D010208:Papaverine
O vliianii gipotermii i antianginal'nykh preparatov s malonatpodobnym deĭstviem na glikoliz i okislitel'noe fosforilirovanie miokarda.