Neuron loss in the nucleus basalis of Meynert in parkinsonism-dementia complex of Guam.
The nucleus basalis of Meynert, which supplies diffuse cholinergic fibers to the cerebral neocortex, was investigated in two cases of parkinsonism-dementia complex of Guam (PDG). The nucleus basalis of the two PDG patients showed extensive neuron loss when compared with age-matched non-Guamanian controls, suggesting the necessity of investigating activity of cholinergic enzymes in the brains of patients with PDG.
D001921:Brain / Q000201:enzymology; D002470:Cell Survival; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003704:Dementia / Q000201:enzymology / Q000473:pathology*; D005260:Female; D006141:Guam; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000201:enzymology / Q000473:pathology*; D013577:Syndrome; D013687:Telencephalon / Q000473:pathology*
D002795:Choline O-Acetyltransferase