Synthesis of [1-Aib]-angiotensin II, an analogue with higher potency than [1-Asn,5-Val]-angiotensin II.
[1-Aib]-angiotensin II was synthesized by Merrifield's solid-phase procedure. The analogue, tested on rabbit aorta strips, showed intrinsic activity alpha E = 1, and when tested on rat blood pressure it gave a pD2 of 8.06; a 3.2 +/- 1.3-fold higher potency than the Ciba-Hypertensin standard.
D000595:Amino Acid Sequence; D000621:Aminoisobutyric Acids; D000802:Angiotensin Amide / Q000494:pharmacology; D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D008722:Methods; D011817:Rabbits; D051381:Rats; D013329:Structure-Activity Relationship
D000621:Aminoisobutyric Acids; D000804:Angiotensin II; D000802:Angiotensin Amide; C037072:angiotensin II, Aib(1)-