title: Estrogen replacement therapy: indications and complications.
abstract: Estrogen replacement therapy is one of the most controversial issues in the field of reproductive medicine. Indications for its use include hot flashes, vaginal atrophy, and risk of osteoporosis. Risk of heart disease may also be an indication but this use has not been firmly established. The role of estrogen replacement therapy in aging changes of skin needs clarification. Complications of therapy include endometrial cancer, breast cancer, hypertension, hyperlipidemia, and gallbladder disease. The last three complications presumably result from hepatic actions of estrogen replacement therapy.
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000139:chemically induced; D002979:Climacteric; D003327:Coronary Disease / Q000188:drug therapy; D004967:Estrogens / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D050356:Lipid Metabolism; D051379:Mice; D010024:Osteoporosis / Q000188:drug therapy; D051381:Rats; D013923:Thromboembolism / Q000139:chemically induced; D014594:Uterine Neoplasms / Q000139:chemically induced
chemical_list: D004967:Estrogens