Effect of dimethindene, an antihistaminic drug, on the transmembrane potentials of mammalian myocardium.
Dimethindene (DMI) decreased the maximum rate of rise of action potential (AP) without changing the resting potential in cat ventricular myocardium. DMI abolished the histamine-induced slow APs in left atria but not in right ventricular papillary muscles of guinea-pig, suggesting that DMI blocked the histamine H1-receptors.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002415:Cats; D004115:Dimethindene / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects
D004115:Dimethindene