[Radioprotective effect of cysteamine entrapped in liposomes orally administered to the mouse].
Cysteamine entrapped in liposomes was orally delivered to Mice and its radioprotective effect observed as a function of the time elapsed between its administration and 60Co gamma irradiation. A protection is manifest up to 3 hrs after administration. This result contrasts with the absence of protection afforded by cysteamine when orally given as an aqueous solution, and with the short lasting activity of its parenteral administration.
D000284:Administration, Oral; D000818:Animals; D003543:Cysteamine / Q000008:administration & dosage / Q000494:pharmacology*; D008081:Liposomes / Q000008:administration & dosage; D008297:Male; D051379:Mice; D011837:Radiation-Protective Agents / Q000008:administration & dosage
D008081:Liposomes; D011837:Radiation-Protective Agents; D003543:Cysteamine
Action radioprotectrice de la cystéamine incorporée dans des liposomes administrés par voie orale à la souris.