2-[(Phenylthio)methyl]pyridine derivatives: new antiinflammatory agents.
2-[(Phenylthio)methyl]pyridine derivatives inhibited the dermal reverse passive Arthus reaction (RPAR) in the rat. In the same model, indomethacin was inactive, and hydrocortisone was active. Compounds Ia-d also significantly reduced exudate volume and white blood cell accumulation in the pleural RPAR. This pattern of activity was similar to that of hydrocortisone and different from that of indomethacin.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D001681:Biological Assay; D002351:Carrageenan; D006854:Hydrocortisone / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D010994:Pleura / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D011725:Pyridines; C037429:2-((phenylthio)methyl)pyridine; D002351:Carrageenan; D006854:Hydrocortisone; D007213:Indomethacin