title: [Effect of nonmutagenic doses of 1,4-bis-diazoacetylbutane on Streptomyces griseus].
abstract: Streptomyces griseus 15 was subjected to the action of 1,4-bis-diazoacetyl butane (DAB) taken at concentrations of 10 to 50,000 micrograms/ml. Small doses (10-100 micrograms/ml) of DAB had no mutagenic action and activated the cultural growth (the viability and the survival rate of spores increased on solid media, while the biomass yield rised in liquid media). Experiments were conducted using the method of orthogonal planning of a bifactorial experiment, and the role of the exposure time rised with a decrease in the mutagen concentration.
mesh_terms: D003470:Culture Media / Q000494:pharmacology; D003979:Diazonium Compounds / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006133:Growth Substances / Q000494:pharmacology*; D009153:Mutagens / Q000494:pharmacology*; D013171:Spores, Bacterial / Q000187:drug effects; D013305:Streptomyces griseus / Q000187:drug effects*
chemical_list: D003470:Culture Media; D003979:Diazonium Compounds; D006133:Growth Substances; D009153:Mutagens; C001588:bis(diazoacetyl)butane
vernacular_title: Vliianie na Streptomyces griseus nemutagennykh doz 1,4-bis-diazoatsetilbutana.