title: Phase 1 study of azosemide (SK-110): single- and multiple-dose study.
abstract: Single and multiple doses of SK-110 were administered orally to healthy volunteers. No subjective or objective symptoms were observed in tests I-I, I-II, I-III, and II, with the exception of dehydration, considered to be a direct effect of the diuretic, which was observed in test I-III. No noteworthy abnormalities were observed in laboratory examinations. One hour after administration of SK-110, urinary output and excretion of urinary electrolytes increased. In test II the diuretic effect of SK-110 continued for about 9 h after administration. Plasma concentration of SK-110 increased in proportion to the doses, and peak concentration was observed 3-4 h after administration. Plasma concentration of SK-110 on the 1st and 5th day of administration showed the same patterns. Drug excretion in the urine was less than 10%.
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004573:Electrolytes / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D013424:Sulfanilamides / Q000378:metabolism / Q000494:pharmacology*; D014554:Urination / Q000187:drug effects; D013777:Tetrazoles; D013876:Thiophenes; D000096926:Benzenesulfonamides
chemical_list: D004232:Diuretics; D004573:Electrolytes; D013424:Sulfanilamides; C018222:azosemide; D013777:Tetrazoles; D013876:Thiophenes; D000096926:Benzenesulfonamides