[Metabolic adaptation to chronic denutrition in anorexia nervosa. Effects of realimentation. Value of the assay of urinary 3-methylhistidine].
Nutritional studies conducted in 9 patients suffering from anorexia nervosa showed a marasmus-like pattern with predominant depletion of lean body mass rather than of visceral proteins. In addition, adaptation to insufficient food intake led to a decrease in myofibrillar breakdown, as evidenced by low levels of urinary 3-methylhistidine. Low-flow enteral feeding resulted, within a few weeks, in return to normal of plasma proteins (particularly those with short half-life), while a dramatic increase in urinary 3-methylhistidine suggested acceleration of muscle protein turnover under adequate calorie-protein intake.
D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D001798:Blood Proteins / Q000378:metabolism; D004750:Enteral Nutrition; D005260:Female; D006639:Histidine / Q000031:analogs & derivatives*; D006801:Humans; D008762:Methylhistidines / Q000652:urine*; D013997:Time Factors
D001798:Blood Proteins; D008762:Methylhistidines; D006639:Histidine; C028118:3-methylhistidine
L'adaptation métabolique à la dénutrition chronique chez l'anorectique mentale - Effet de la réalimentation. Intérêt du dosage de la 3-méthylhistidine urinaire.