[Implication of gamma-aminobutyric acid (GABA) at the mesencephalic central gray level, in the elaboration of flight responses].
In the rat, a microinjection of bicuculline methiodide (0.03 to 0.065 nmole) into the mesencephalic central gray (GC) provokes a flight response. At a lower dose, it reduces - or increases - the latency with which the rat switches off an electrical stimulation applied to the GC. This latency is regularly increased by a local microinjection of muscimol. These results suggest that a GABAergic link within the GC is involved in the generation of an aversive effect and of the flight response which may express it.
D000374:Aggression; D000818:Animals; D001640:Bicuculline / Q000031:analogs & derivatives* / Q000494:pharmacology; D004924:Escape Reaction / Q000187:drug effects*; D006801:Humans; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
C017069:bicuculline methiodide; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline
Intervention de l'acide gamma-aminobutyrique (GABA) au niveau de la substance grise centrale du mésencéphale, dans l'élaboration d'une réponse de fuite.