[Study of the toxicity of carminomycin 13-cyclohexylidenhydrazone].
The systemic effect and toxicity of carminomycin 13-cyclohexylidenhydrazone (CCH) were studied on noninbred albino mice in comparison to carminomycin. The preparation was administered intravenously and orally. It was shown that CCH was 1.3 or 2.5 times less toxic than carminomycin on its intravenous or oral administration, respectively. The cumulative properties of CCH and carminomycin on their intravenous administration were practically equal. On oral administration of CCH the level of its cumulation in mice was higher than that of carminomycin. By its nature the effect of the preparations on hemopoiesis of the mice was the same. CCH had a low cardiotoxic effect.
D000284:Administration, Oral; D000818:Animals; D001772:Blood Cell Count; D002360:Carubicin / Q000031:analogs & derivatives / Q000633:toxicity*; D003630:Daunorubicin / Q000031:analogs & derivatives*; D006321:Heart / Q000187:drug effects*; D006410:Hematopoiesis / Q000187:drug effects*; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D051379:Mice; D009206:Myocardium / Q000473:pathology; D009929:Organ Size
D002360:Carubicin; D003630:Daunorubicin
Izuchenie toksichnosti 13-tsiklogeksilidengidrazona karminomitsina.