title: Hemodynamic effects of concomitant nitroglycerin ointment and nifedipine treatment in acute myocardial infarction.
abstract: Nitroglycerin ointment and nifedipine were used concurrently for vasodilator therapy in 10 patients with acute myocardial infarction. Nitroglycerin ointment 20 mg (4 cm) induced a significant reduction in pulmonary capillary wedge pressure from 14.1 +/- 1.8 (mean +/- standard error of the mean) to 12.4 +/- 1.2 mmHg (p less than 0.05) 30 min after application, while cardiac output, mean blood pressure, and systemic vascular resistance did not show a significant change. When nifedipine 10 mg was added orally, mean blood pressure significantly decreased from 99.0 +/- 6.3 to 82.8 +/- 5.9 mmHg (p less than 0.005) and systemic vascular resistance from 25.7 +/- 1.5 to 19.2 +/- 1.6 units (p less than 0.001) 30 min after; on the other hand, cardiac index significantly increased from 2.28 +/- 0.12 to 2.57 +/- 0.14 l/min/m2 (p less than 0.001). From these results, it was concluded that combined use of these two drugs was a useful and safe form of unloading therapy.
mesh_terms: D000368:Aged; D001794:Blood Pressure; D002302:Cardiac Output / Q000187:drug effects; D004359:Drug Therapy, Combination; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology*; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology*; D009824:Ointments; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D011725:Pyridines / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D009824:Ointments; D011725:Pyridines; D005996:Nitroglycerin; D009543:Nifedipine