Childhood craniopharyngioma: survival, local control, endocrine and neurologic function following radiotherapy.
Between 1961 and 1978, 19 patients with a diagnosis of childhood or teenage craniopharyngioma received supervoltage radiotherapy. All patients had previously undergone either partial surgical resection (10 patients), total gross resection (3 patients), or aspiration and biopsy (6 patients). Fourteen patients were treated primarily and five were treated for recurrence. The five-year survival was 73% with a 10-year survival of 64%. Sixteen percent developed a recurrence following radiotherapy. Long term effects were assessed in terms of neurologic, intellectual, psychological and endocrine function. Seventy-nine percent had none or minimal neurologic disability. The mean full scale IQ for the group was 90. There were no additional endocrine deficiencies that could be directly attributed to radiation. Behavioral disorders occurred in 50%. These results are at least comparable, if not superior, to those of surgery.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003397:Craniopharyngioma / Q000401:mortality / Q000503:physiopathology / Q000523:psychology / Q000532:radiotherapy* / Q000601:surgery; D004702:Endocrine Glands / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D009460:Neurologic Examination; D010911:Pituitary Neoplasms / Q000401:mortality / Q000503:physiopathology / Q000523:psychology / Q000532:radiotherapy* / Q000601:surgery; D011379:Prognosis