title: Biological dosimetry by chromosome aberration scoring with parallel image processing with the Heidelberg POLYP Polyprocessor system.
abstract: Chromosome aberrations in human peripheral blood are recognized parameters of cellular damage and are used as indicators of exposure to ionizing radiation. In order to reach the low dose range, up to 10,000 metaphase cells each consisting of 46 chromosomes have to be analysed for each radiation exposed person. In order to perform this task within reasonable time limits the application of the Heidelberg POLYP Polyprocessor is considered. The POLYP consists of a number of processor modules and several global memory modules which are interconnected by a multi-common-bus for parallel data transfers and a multiple synchronization bus for processor/task-scheduling. The system is designed for handling large amounts of data in real time as is typical for image processing applications.
mesh_terms: D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects*; D003201:Computers; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008677:Metaphase; D008838:Microcomputers; D010363:Pattern Recognition, Automated