[Global pancreatic and gastric deficiency after a familial membranous glomerulonephritis in a child treated by corticoids and chlorambucil for a long time (author's transl)].
A 2-year-old boy with familial extramembranous glomerulonephritis was unfortunately treated with corticosteroids (1 to 0.5 mg/kg/day) and Chlorambucil (cumulative dose: 2.5 g) over a period of 7 years. Three years later, after recovery from the renal affection, he developed fatty diarrhoea from exocrine pancreatic deficiency, followed 5 years later by the onset of diabetes with hypochlorhydric gastritis. The diagnosis of non-calcifying chronic pancreatitis was suggested by scintigraphic and ultrasonographic investigations and confirmed by the marked increase in lactoferrin levels and the lactoferrin/lipase ratio (greater 0.1 p. cent) in pancreatic juice. The etiology was more likely to be direct toxicity of corticoids and/or immunosuppressors on the pancreas than an immunologically-mediated disease.
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D002699:Chlorambucil / Q000009:adverse effects*; D005756:Gastritis / Q000139:chemically induced* / Q000473:pathology; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D008134:Long-Term Care; D008297:Male; D010182:Pancreatic Diseases / Q000139:chemically induced*; D010375:Pedigree
D000305:Adrenal Cortex Hormones; D002699:Chlorambucil
Déficit pancréatique global et gastrite, à distance d'une glomérulonéphrite extra-membraneuse familiale chez un enfant soumis à un traitement prolongé par corticoïdes et Chloraminophène.