title: [Morphometric analysis of local immune reactions in the larynx of rats under the effect of methylcholanthrene].
abstract: Local reactions of cellular immunity in laryngeal tissues were studied in the course of experimental carcinogenesis induced by painting rats' laryngeal mucosa with a methylcholanthrene solution. The morphometric analysis established a decrease in the total count of lymphocytes and an increase in the fraction of their pyroninophilic forms in the lymphoid infiltrates of laryngeal mucosa. Also, immunoglobulin-producing cells were observed during the malignant transformation of laryngeal epithelium. At the early stages of proliferative processes occurring in the larynx, the functional activity of lymphocytes and their ability to undergo blasttransformation and to stimulate the synthesis of immunoglobulin-producing cells were increased, although the total count of lymphocytes in lymphoid infiltrates was decreased.
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000032:analysis; D007822:Laryngeal Neoplasms / Q000276:immunology*; D007830:Larynx / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008748:Methylcholanthrene; D009092:Mucous Membrane / Q000276:immunology; D009374:Neoplasms, Experimental / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007136:Immunoglobulins; D008748:Methylcholanthrene
vernacular_title: Morfometricheskiĭ analiz mestnykh immunnykh reaktsiĭ v gortani krys pri vozdeĭstvii metilkholantrenom.