title: Effect of bombesin on gastric secretion and motility in the cat.
abstract: The effect of bombesin on acid and pepsin secretion and antral motility was compared to that of pentagastrin in conscious cats. Bombesin stimulated acid secretion to 65% of the maximal response to pentagastrin but induced a stronger pepsin secretion than any dose of pentagastrin. As to antral motility, bombesin first induced an effect comparable to that of pentagastrin, with an increase of low-amplitude and a decrease of high-amplitude contractions. After about 30 min of continuous infusion, the effect of bombesin changed with a return to basal frequency for the low-amplitude contractions and an increase of high-amplitude contractions. This effect was not observed with pentagastrin nor cholecystokinin and was not explained by the variations of plasma insulin concentration.
mesh_terms: D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D002415:Cats; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007328:Insulin / Q000097:blood; D008297:Male; D010434:Pepsin A / Q000378:metabolism; D010455:Peptides / Q000494:pharmacology*; D011706:Pyloric Antrum / Q000187:drug effects
chemical_list: D005755:Gastrins; D007328:Insulin; D010455:Peptides; D010434:Pepsin A; D001839:Bombesin