A new reproducible experimental model of analgesic nephropathy.
The uninephrectomised homozygous Gunn rat is more sensitive than other experimental animals to the nephrotoxic effects of analgesics. Phenacetin derivatives produce severe necrosis of proximal convoluted tubules and aspirin and phenazone renal papillary necrosis. The observations suggest that the components of compound analgesic preparations have separate and complementary nephrotoxic effects, and this is a possible factor contributing to the association of analgesic nephropathy with abuse of such preparations.
D000082:Acetaminophen / Q000009:adverse effects; D000700:Analgesics / Q000009:adverse effects*; D000818:Animals; D000983:Antipyrine / Q000009:adverse effects; D001241:Aspirin / Q000009:adverse effects; D004195:Disease Models, Animal; D005260:Female; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced*; D007681:Kidney Papillary Necrosis / Q000139:chemically induced / Q000473:pathology; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced / Q000473:pathology; D008099:Liver / Q000187:drug effects; D051381:Rats; D011911:Rats, Gunn
D000700:Analgesics; D000082:Acetaminophen; D001241:Aspirin; D000983:Antipyrine