The effect of combined gentamicin-corticosteroid treatment on gentamicin-resistant Pseudomonas keratitis.
In an experimental model of Pseudomonas keratitis caused by a gentamicin-resistant strain of Ps aeruginosa, the results of treatment with gentamicin alone and a gentamicin-steroid combination were evaluated. Treatment with steroids did not reduce the amount of corneal inflammation when compared to eyes treated with gentamicin alone. Eyes treated with the gentamicin-steroid combination were, however, infected with a statistically significant greater number of organisms at the end of a 3-day treatment period. Corticosteroids probably should not be used in the treatment of Pseudomonas keratitis during the early period when the antibiotic sensitivities of the organism are not known.
D000818:Animals; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D005839:Gentamicins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007634:Keratitis / Q000188:drug therapy* / Q000209:etiology; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011817:Rabbits; D013997:Time Factors; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000627:therapeutic use*
D005839:Gentamicins; D014222:Triamcinolone Acetonide