title: [Administration of vaccine against myxomatosis using live MXT by means of external ear puncture with a special needle].
abstract: A new application method was developed and tested for the immunoprophylaxis of rabbits against myxomatosis using a live MXT vaccine. This new application method--injection of the ear with a special double needle--is very simple and easy. Its use enables a five-fold increase in vaccination doses as compared with subcutaneous application while the amount of vaccine remains the same. In laboratory this method with the MXT vaccine secured a 98.2% protection of the vaccinated animals. One vaccination dose contains 18.1 to 37.2 PD50. Eleven months from a single vaccination by injecting the ear, 83% of the rabbits still remained protected against experimental infection. With the use of the new application method of injecting the ear with the special double needle, the live MXT vaccine against myxomatosis in rabbits represents an effective, easily practicable and economically advantageous direction in the immunoprophylaxis of rabbits against myxomatosis.
mesh_terms: D000818:Animals; D004431:Ear, External; D007109:Immunity; D009233:Myxoma virus / Q000276:immunology*; D009234:Myxomatosis, Infectious / Q000517:prevention & control*; D009339:Needles; D011817:Rabbits; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D014765:Viral Vaccines
vernacular_title: Aplikace vakcíny proti myxomatóze zivé MXT průpichem usního boltce speciální dvojjehlou.