Effect of old age on paracetamol-induced lipid peroxidation in rat liver.
Post-mitochondrial supernatants isolated from the livers of mature rats (3 to 6 months old) 2 h or more after the administration of a single large oral dose of paracetamol (800 mg/kg) showed rapid rates of lipid peroxidation when incubated in vitro. In similar experiments with old rats (27-30 months old) the time between administration of paracetamol and the onset of lipid peroxidation was much longer (6 h or more). In both age groups, lipid peroxidation was dependent on the depletion of glutathione from the liver.
D000082:Acetaminophen / Q000494:pharmacology*; D000375:Aging; D000818:Animals; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D008054:Lipid Peroxides; D000082:Acetaminophen; D005978:Glutathione