Tumorigenicity of citrinin in male F344 rats.
This study reports on the tumorigenicity of citrinin, a nephrotoxic mycotoxin. Male F344 rats were fed 0.1% citrinin in the diet for up to 80 weeks. The first renal tumor was seen grossly in a rat receiving citrinin which was killed at week 52. Histopathology of the kidneys showed renal adenomas in 35 of 48 (72.9%) rats that survived after 40 weeks. No renal tumors were seen in the control rats.
D000236:Adenoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D001578:Benzopyrans / Q000633:toxicity*; D002273:Carcinogens; D002953:Citrinin / Q000633:toxicity*; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009374:Neoplasms, Experimental / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344
D001578:Benzopyrans; D002273:Carcinogens; D002953:Citrinin