Pharmacokinetics of auranofin in animals.
Gold from orally administered auranofin (AF) was absorbed 17-23% in rats and 15-38% in dogs. Gold was highly bound to blood cells and plasma proteins. Gold terminal half life was 1.2-1.8 days in rat blood and plasma (measured for 7 days post dose) and 19.5 days in the dog (measured for 42 days). Excretion of gold (rat and dog) was via feces (84 and 81%) urine (10 and 16%) and bile (3% of dose). Rat tissue levels of gold were highest in the kidney. Evidence indicated that AF was rapidly degraded to triethylphosphine oxide with the remaining molecular fragments postulated to be a protein-gold complex and acetylthioglucose.
D000818:Animals; D001310:Auranofin; D006051:Aurothioglucose / Q000031:analogs & derivatives* / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D004285:Dogs; D005260:Female; D006046:Gold / Q000031:analogs & derivatives* / Q000097:blood / Q000652:urine; D007700:Kinetics; D008297:Male; D010761:Phosphorus Radioisotopes; D051381:Rats; D011919:Rats, Inbred Strains; D013462:Sulfur Radioisotopes
D001798:Blood Proteins; D010761:Phosphorus Radioisotopes; D013462:Sulfur Radioisotopes; D006051:Aurothioglucose; D001310:Auranofin; D006046:Gold