title: The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats.
abstract: This study examined the effects of an aldose reductase inhibitor (CP 45634, Sorbinil, Pfizer, New York, New York) on the neuropathy of streptozotocin-induced diabetic rats. Sorbinil treatment for 4 wk reduced sciatic nerve sorbitol concentration and improved motor nerve conduction velocity in diabetes of 2-9 mo duration. It remains to be determined whether Sorbinil can prevent chronic diabetic neuropathy.
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D005260:Female; D007093:Imidazoles / Q000494:pharmacology*; D048289:Imidazolidines; D009046:Motor Neurons / Q000502:physiology*; D009431:Neural Conduction / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000032:analysis; D013012:Sorbitol / Q000032:analysis; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*; D013997:Time Factors
chemical_list: D007093:Imidazoles; D048289:Imidazolidines; D013012:Sorbitol; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase; C026411:sorbinil