The inhibitory effect of some lectins on the differentiation of Friend erythroleukemia cells.
Growth and differentiation of Friend cells can be inhibited by treatment with concanavalin A and wheat-germ agglutinin. This inhibition is specific for cells that are in the early stages of the differentiation process (24-48 h after the addition of dimethyl sulfoxide) and is reversible upon treatment with the sugars competitive for these lectins. These results suggest a regulatory role for some plasma membrane-bound glycoproteins early in the differentiation of Friend erythroleukemia cells induced by dimethyl sulfoxide.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002999:Clone Cells; D003208:Concanavalin A; D006454:Hemoglobins / Q000096:biosynthesis; D037102:Lectins / Q000494:pharmacology*; D007942:Leukemia, Experimental / Q000503:physiopathology*; D051379:Mice; D011952:Receptors, Concanavalin A / Q000378:metabolism; D013329:Structure-Activity Relationship
D006454:Hemoglobins; D037102:Lectins; D011952:Receptors, Concanavalin A; D003208:Concanavalin A