Reversal of the anticonvulsant effects of diazepam on amygdaloid-kindled seizures by a specific benzodiazepine antagonist: RO 15-1788.
The benzodiazepine antagonist RO 15-1788 was tested in an animal model of experimental epilepsy, the kindling effect. In animals fully kindled from repeated electrical amygdaloid stimulation, RO 15-1788 reversed the anticonvulsant effects of diazepam (2 mg/kg) from doses of 0.4-0.5 mg/kg. Doses up to 20 mg/kg also antagonized the preventive action of diazepam. RO 15-1788 alone had neither proconvulsant effects on the amygdaloid afterdischarges nor benzodiazepine-like activity on the kindled seizures.
D000679:Amygdala / Q000502:physiology; D000818:Animals; D000927:Anticonvulsants / Q000037:antagonists & inhibitors*; D001570:Benzodiazepinones / Q000494:pharmacology*; D003975:Diazepam / Q000037:antagonists & inhibitors*; D004569:Electroencephalography; D005442:Flumazenil; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000927:Anticonvulsants; D001570:Benzodiazepinones; D005442:Flumazenil; D003975:Diazepam