HLA-DR specifications in Japanese with juvenile-onset insulin-dependent diabetes mellitus.
Specific allelic associations vary among ethnic groups. We studied the distribution of HLA-A,-B,-C, and -DR antigens in 34 Japanese juvenile-onset diabetic patients. The focus of our current work was HLS-DR antigens because there have been few studies of Japanese with this disease. A significant increase in the frequency of HLA-DR4 was found in patients but not in unaffected persons: DR4 was found in 56.3% of the patients versus 32.6% of the unaffected persons. However, the negative correlation between DR2 and patients was not statistically significant.
D000293:Adolescent; D000328:Adult; D000483:Alleles; D044466:Asian People; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000235:genetics; D006684:HLA-DR Antigens; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged
D006680:HLA Antigens; D006684:HLA-DR Antigens