Generalization of the discriminative stimulus properties of phencyclidine to other drugs in the pigeon using color tracking under second order schedules.
Pigeons were trained to track the location of a red or green key color under a second order schedule, with reinforcement of responses to each color contingent upon whether 1.5 mg/kg phencyclidine (PCP) or saline had been administered before the session. When cumulative dose-effect curves were determined for other drugs substituted for PCP, pigeons responded predominantly on the PCP key after other doses of PCP, ketamine, pentobarbital, d-cyclazocine and l-cyclazocine, but not after saline, lactic acid solution, d-amphetamine, chlordiazepoxide, scopolamine, morphine, naltrexone, or d-, or l-methadone. l-Cyclazocine was slightly more potent than d-cyclazocine in producing PCP key responding. PCP key responding after the optical isomers of cyclazocine was not blocked by naltrexone.
D000818:Animals; D010856:Columbidae; D003496:Cyclazocine / Q000494:pharmacology; D004192:Discrimination, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005795:Generalization, Stimulus / Q000187:drug effects*; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D010622:Phencyclidine / Q000494:pharmacology*; D012055:Reinforcement Schedule
D007649:Ketamine; D010424:Pentobarbital; D010622:Phencyclidine; D003496:Cyclazocine