title: Biochemical and antitumor effects of 5,8-dideazaisopteroylglutamate, a unique quinazoline inhibitor of thymidylate synthase.
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002460:Cell Line; D003110:Colonic Neoplasms / Q000188:drug therapy*; D005260:Female; D005493:Folic Acid Antagonists; D006801:Humans; D007939:Leukemia L1210 / Q000201:enzymology; D008727:Methotrexate / Q000627:therapeutic use; D008780:Methyltransferases / Q000037:antagonists & inhibitors*; D051379:Mice; D008810:Mice, Inbred C57BL; D011799:Quinazolines / Q000627:therapeutic use*; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*
chemical_list: D000970:Antineoplastic Agents; D005493:Folic Acid Antagonists; D011799:Quinazolines; C035530:5,8-dideazaisofolic acid; D008780:Methyltransferases; D013940:Thymidylate Synthase; D008727:Methotrexate