Experimental study on Meniere's disease.
Experimental hydrops caused by underabsorption of endolymphatic fluid is a model of remissional stage of Meniere's disease. In this study, another type of model, ie, hydrops caused by overproduction of endolymphatic fluid, was accomplished by applying various pressures into scala media through a micropipette via stria vascularis. This type of hydrops could be a model of attacks of Meniere's disease. By using two types of the model, effects of glycerol administration and of opening the endolymphatic sac were discussed.
D000818:Animals; D001300:Audiometry, Evoked Response; D003051:Cochlea / Q000473:pathology / Q000503:physiopathology*; D003053:Cochlear Duct / Q000503:physiopathology*; D004584:Electronystagmography; D004710:Endolymph / Q000502:physiology*; D006168:Guinea Pigs; D007761:Labyrinthine Fluids / Q000502:physiology*; D008575:Meniere Disease / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D011312:Pressure