Chronic infusion of angiotensin II into the olfactory bulb elicits an increase in water intake.
Chronic infusion of angiotensin II (ANG II) into the olfactory bulb (OB) elicited a moderate dipsogenesis which occurred only during the dark phase, essentially doubling the water-to-food intake ratio. Removal of the food from the ANG II-OB group reduced water consumption to the level of the saline-infused/food-deprived controls. These experiments suggest that ANG II may interact with the OB to alter the normal water/food relationship.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D009830:Olfactory Bulb / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011945:Receptors, Angiotensin / Q000187:drug effects; D014882:Water-Electrolyte Balance / Q000187:drug effects
D011945:Receptors, Angiotensin; D000804:Angiotensin II