[Pharmacological study of pirprofen].
Pirprofen is a new non-steroidal anti-inflammatory drug. Its formula is 2 - (3 - chloro - 4 (3 - pyrrolin - 1 - yl)-phenyl) propionic acid. As demonstrated by the nitrogen nucleus and the the 2 pKA values, the molecule is similar to that of an amino acid. The classical pharmacological studies have proven its powerful anti-inflammatory action. Certain new techniques have enabled the identification of the mechanism of action of pirprofen in the inflammatory process. In addition, pirprofen seems able to slow down the evolution of certain experimental models of osteoarthritis. The mechanism of this effect is unknown.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000633:toxicity; D001169:Arthritis, Experimental / Q000188:drug therapy; D002633:Chemotaxis / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors; D004285:Dogs; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010666:Phenylpropionates / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D011917:Rats, Inbred Lew
D000893:Anti-Inflammatory Agents; D016861:Cyclooxygenase Inhibitors; D010666:Phenylpropionates; C008924:pirprofen
Etude pharmacologique du pirprofène.