Tissue distribution of lead in the neonatal rat exposed to multiple doses of lead acetate.
The tissue distribution of lead (Pb) was examined in the neonatal rat intragastrically administered lead acetate (50 mg/kg, containing 210Pb) beginning on d 6 postpartum and thereafter at 3-d intervals to d 18. A time-dependent pattern of uptake was observed in bone, kidney, liver, and brain, while stomach, lung, heart, and spleen had no accumulation of Pb. The highest concentration of Pb at d 21 was detected in bone, and the least amount was found in blood and brain. Body weight was not significantly affected by the level of Pb exposure employed.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D005260:Female; D007854:Lead / Q000009:adverse effects / Q000032:analysis* / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D009942:Organometallic Compounds; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014018:Tissue Distribution
D009942:Organometallic Compounds; D007854:Lead; C008261:lead acetate