Paradoxical anti-leukemic effects of plant-derived tumor promoters on a human thymic lymphoblast cell line.
Three different diterpen polyols and the teleocidin have antileukemic effects on the human thymic leukemia cell line HPB-ALL by inducing phenotypic differentiation. We tested TPA (phorbol esters), mezerein (daphnane), milliamin (ingenol ester) and teleocidin B (teleocidins) as representative of the chemical structure of each principle and found that these agents have the similar biological activity of inducing phenotypic differentiation in HPB-ALL cells. Moreover, competitive binding of [3H]PDB to cell-surface receptors was significantly inhibited by these agents; n-butyrate and phorbol per se did not inhibit the binding of [3H]PDB. Despite differences in the structure of the principles, these agents may have similarly acting side-chain structures.
D000470:Alkaloids / Q000494:pharmacology*; D000954:Antigens, Surface / Q000032:analysis; D002273:Carcinogens / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis; D004224:Diterpenes / Q000494:pharmacology; D005455:Fluorescent Antibody Technique; D006801:Humans; D007945:Leukemia, Lymphoid / Q000378:metabolism / Q000473:pathology*; D008235:Lyngbya Toxins; D015240:Phorbol 12,13-Dibutyrate; D010703:Phorbol Esters / Q000378:metabolism / Q000494:pharmacology; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism; D012397:Rosette Formation; D013601:T-Lymphocytes; D013729:Terpenes
D000470:Alkaloids; D000954:Antigens, Surface; D002273:Carcinogens; D004224:Diterpenes; D008235:Lyngbya Toxins; D010703:Phorbol Esters; D013729:Terpenes; D011064:Poly Adenosine Diphosphate Ribose; C022176:teleocidins; C011309:mezerein; D015240:Phorbol 12,13-Dibutyrate; D004247:DNA