[Effect of 2,4-dinitrophenol on the synthesis of ribosomal RNA in the cells of Ehrlich ascitic carcinoma under anaerobic conditions].
It is shown that 2,4-DNP (20 mkM to 1 mM) selectively inhibited RNA synthesis in Ehrlich ascite carcinoma cells both in aerobic and in anaerobic conditions in equal extent. It is supposed that the inhibitory action of DNP is not associated with its influence on oxidative phosphorylation and intracellular ATP concentration, but may be accounted for cell reaction to non-specific actions.
D000332:Aerobiosis / Q000187:drug effects; D000693:Anaerobiosis / Q000187:drug effects; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002478:Cells, Cultured; D004140:Dinitrophenols / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D051379:Mice; D012334:RNA, Neoplasm / Q000096:biosynthesis*; D012335:RNA, Ribosomal / Q000096:biosynthesis*
D004140:Dinitrophenols; D012334:RNA, Neoplasm; D012335:RNA, Ribosomal
Vliianie 2,4-dinitrofenola na sintez ribosomnoĭ RNK v kletkakh astsitnoĭ kartsinomy Erlikha v anaérobnykh usloviiakh.