title: Transition of benign vaginal adenosis to clear cell carcinoma.
abstract: The transition from benign adenosis to clear cell carcinoma of the vagina has not been established beyond doubt. The history of a patient regularly followed in a diethystilbestrol (DES) clinic shows initial benign adenosis with normal cytology and subsequent development of abnormal cytology and clear cell adenocarcinoma. The authors suspect transition from benign epithelium to malignancy; however, detailed serial histologic study failed to show clear transition. Frequent and thorough examination of DES patients is needed if malignant change is to be diagnosed early.
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology*; D000328:Adult; D002471:Cell Transformation, Neoplastic; D004054:Diethylstilbestrol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D014623:Vaginal Diseases / Q000139:chemically induced / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000139:chemically induced / Q000473:pathology*
chemical_list: D004054:Diethylstilbestrol