Fasting pancreatic glucagon in Jamaican children during malnutrition and subsequent recovery.
Fasting pancreatic glucagon was observed in Jamaican infants during malnutrition and subsequent recovery. Rehabilitation in two groups of children with isocaloric diets rich either in carbohydrate or fat produced no differences in the rate of weight gain. During malnutrition, plasma pancreatic glucagon concentration was 104 +/- 11 (n = 20) pg/ml (mean +/- S.E.) significantly lower than during recovery when the maximum value was 180 +/- 24 (n = 13) pg/ml during the later recovery phase. After clinical recovery glucagon levels declined to 127 +/- 13 (n = 15) pg/ml. Plasma insulin followed a similar pattern, increasing significantly during catch-up growth and declining after recovery. Slower rates of growth were associated with the simultaneous decline in the concentrations of both hormones after clinical recovery.
D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002149:Energy Intake; D005215:Fasting; D005934:Glucagon / Q000097:blood*; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007223:Infant; D007328:Insulin / Q000097:blood; D007563:Jamaica; D010179:Pancreas / Q000378:metabolism*; D011502:Protein-Energy Malnutrition / Q000097:blood* / Q000178:diet therapy
D001786:Blood Glucose; D007328:Insulin; D013006:Growth Hormone; D005934:Glucagon