Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
Chain modification of a thiazolidinone prostaglandin isostere has led to the production of 4-[3-[3-[2-(1-hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinyl]propyl] benzoic acid (5b) which at 1 mg/kg po in the conscious dog causes a 70% increase in renal blood flow over control values with a duration of action exceeding 5 h. Preliminary testing indicates that 5b has a relatively specific action on the vasculature of the kidney. The enantiomers of 5b have been separated and the renal vasodilatory activity has been found to be entirely a property of the R-(+) enantiomer.
D000818:Animals; D004285:Dogs; D005260:Female; D007668:Kidney / Q000098:blood supply*; D008958:Models, Molecular; D012039:Regional Blood Flow / Q000187:drug effects; D013237:Stereoisomerism; D013844:Thiazoles / Q000494:pharmacology*; D053778:Thiazolidines; D014655:Vascular Resistance / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects*; D014961:X-Ray Diffraction
D013844:Thiazoles; D053778:Thiazolidines; C035264:4-(3-((2-(1-hydroxycyclohexyl)ethyl)-4-oxo-2-thiazolidinyl)propyl)benzoic acid