Reversible obesity and plasma fat metabolites.
Rats were made to overeat and gain weight (about 50 g) by long-acting protamine zinc insulin (PZI) treatment. When the PZI treatment was stopped, the rats ate much less than normal for at least seven days. During recovery from PZI-induced obesity, negative correlations were observed between food intake and plasma levels of the fat metabolites, free fatty acids, glycerol, and ketone bodies. A similar but smaller effect was observed during recovery from dietary obesity (about 15 g). The plasma fat metabolites may be the blood-borne signals which suppress hunger under these conditions.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005990:Glycerol / Q000097:blood; D049528:Insulin, Long-Acting / Q000494:pharmacology; D007657:Ketone Bodies / Q000097:blood; D008055:Lipids / Q000097:blood*; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005230:Fatty Acids, Nonesterified; D049528:Insulin, Long-Acting; D007657:Ketone Bodies; D008055:Lipids; D005990:Glycerol