Effect of metoclopramide and lisuride on hypophyseal and gonadal function in men.
The effects of chronic treatment over 7 weeks with metoclopramide and lisuride alone as well as the combination of both drugs were studied on basal and TRH/LHRH stimulated serum PRL, testosterone, LH, FSH, GH, and TSH concentrations. The study was conducted under double-blind placebo-controlled conditions and included twenty-four healthy male volunteers. In addition, repeated seminal fluid analyses were performed before, during and after treatment. While the known PRL-stimulatory effect of metoclopramide and the PRL-lowering effect of lisuride could be confirmed, we were unable to demonstrate any substance-related effects on the other hypophyseal or gonadal hormones. In contrast to previously published data no adverse effects of metoclopramide on sperm analysis could be demonstrated.
D000328:Adult; D004347:Drug Interactions; D004873:Ergolines / Q000494:pharmacology*; D005298:Fertility / Q000187:drug effects; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D008090:Lisuride / Q000494:pharmacology*; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D010902:Pituitary Gland / Q000187:drug effects*; D011388:Prolactin / Q000097:blood; D013094:Spermatozoa / Q000032:analysis; D013737:Testis / Q000187:drug effects*; D013973:Thyrotropin-Releasing Hormone
D004873:Ergolines; D007987:Gonadotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D008090:Lisuride; D008787:Metoclopramide