title: Inhibition of DNA synthesis does not influence the H1 histone synthesis in Tetrahymena pyriformis.
abstract: In the protozoan Tetrahymena pyriformis the DNA synthesis is stopped immediately and completely after addition of one of the two DNA synthesis inhibitors methotrexate + uridine and hydroxyurea to a cell suspension. However, the present experiments show, that the accumulation of labeled H1 histone in the inhibited cells is almost totally unaffected for more than two-thirds of a cell cycle after addition of either inhibitor.
mesh_terms: D000818:Animals; D004261:DNA Replication / Q000187:drug effects*; D006657:Histones / Q000235:genetics*; D006918:Hydroxyurea / Q000494:pharmacology*; D007700:Kinetics; D008727:Methotrexate / Q000494:pharmacology*; D013769:Tetrahymena pyriformis / Q000187:drug effects / Q000378:metabolism*; D014529:Uridine / Q000494:pharmacology
chemical_list: D006657:Histones; D014529:Uridine; D006918:Hydroxyurea; D008727:Methotrexate