[Effect of a selective inhibitor of ribosomal RNA on induction of differentiation of the Friend cell].
The selective inhibitor of ribosomal RNA synthesis toyocamycin, abolishes at very low concentrations, the erythroid differentiation of Friend cells when used under conditions where other inhibitors of DNA and RNA synthesis do not impede differentiation. Toyocamycin does not inhibit the synthesis of 16 S premessager RNA for globin, nor does it prevent splicing for mature 9 S globin messenger. Inhibition of differentiation might be explained by an effect at the translation level.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D004273:DNA, Neoplasm / Q000235:genetics; D005914:Globins / Q000235:genetics; D007942:Leukemia, Experimental / Q000503:physiopathology*; D051379:Mice; D014176:Protein Biosynthesis / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics; D012335:RNA, Ribosomal / Q000235:genetics*; D012263:Ribonucleosides / Q000494:pharmacology*; D014127:Toyocamycin / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects*
D004273:DNA, Neoplasm; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D012335:RNA, Ribosomal; D012263:Ribonucleosides; D005914:Globins; D014127:Toyocamycin
Effet d'un inhibiteur sélectif des synthèses des ARNs ribosomiques sur l'induction de la différenciation de la cellule de Friend.