Pancytopenia due to hemophagocytosis in patients with brucellosis: a report of four cases.
In 42 patients with brucellosis who had bone-marrow cultures performed, five had hemophagocytosis, four of whom demonstrated peripheral hemocytopenia. All five patients with hemophagocytosis had Brucella melitensis isolated from both blood and bone-marrow cultures. Infectious diseases such as brucellosis should be considered in patients whose clinical picture suggests malignant histiocytosis, especially in geographic areas where brucellar infections are common.
D000293:Adolescent; D000368:Aged; D001772:Blood Cell Count; D001856:Bone Marrow Examination; D002002:Brucella; D002006:Brucellosis / Q000097:blood / Q000150:complications*; D006801:Humans; D008264:Macrophages / Q000502:physiology; D008297:Male; D008875:Middle Aged; D010198:Pancytopenia / Q000097:blood / Q000209:etiology*; D010587:Phagocytosis