[Effect of bovine and porcine calcitrin on bone tissue regeneration of irradiated jaws in an experiment].
A study was made of the effect of swine and bovine calcitrine (CT) on the reparation of irradiated maxillary osseous tissue in 240 rats using histological and histochemical methods. Both types of CT have shown a similar unidirectional effect: the weakening of post-irradiation resorption, the strengthening of osteogenesis, increased preservation of osteogenic cells, and the return of glycosoaminoglycan metabolism to normal. The efficacy of action of swine CT proved to be one order higher as compared to bovine. The authors are of opinion that the most rational dose of swine CT under the conditions of this experiment is 0.2 units/kg to stimulate a quickened method of bone formation. At the onset of treatment an elevation of the hormone dose with its gradual decrease to the optimum one is permissible.
D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects* / Q000528:radiation effects; D002116:Calcitonin / Q000494:pharmacology*; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D007568:Jaw / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013552:Swine
D002116:Calcitonin
Vliianie bych'ego i svinogo kal'tsitrina na reparatsiiu kostnoĭ tkani obluchennykh cheliusteĭ v éksperimente.