title: Genetic effects of 1,2-dibromo-3-chloropropane (DBCP) in Drosophila.
abstract: Induction of sex-linked recessive lethal mutations, heritable translocations and genetic crossing-over were studied in Drosophila melanogaster males treated as adults and as embryos with different concentrations of gaseous DBCP. Adults exposed to 30 ppm/hr of the compound did not produce a significant number of sex-linked recessive lethal mutations in treated spermatozoa, spermatids, or spermatocytes. However, at an exposure of 17.7 ppm/hr, a weak mutagenic effect was observed in embryonic spermatogonia. No translocation was scored in 4032 tested chromosomes from adults treated with 150 ppm/hr. However, a significant number of spermatocytial crossovers were induced after an exposure of 120 ppm/hr.
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000196:embryology; D005804:Genes, Lethal / Q000187:drug effects; D005808:Genes, Recessive / Q000187:drug effects; D008297:Male; D009153:Mutagens; D011407:Propane / Q000031:analogs & derivatives* / Q000633:toxicity; D013997:Time Factors
chemical_list: D009153:Mutagens; C007318:1,2-dibromo-3-chloropropane; D011407:Propane