Predominant expression of zeta and epsilon globin genes in human leukemia K-562(S6) variant cell line.
In the human leukemia K-562(S6) cell line (a) the accumulation of alpha-globin chains is low or absent, (b) zeta-globin gene expression is correlated with expression of epsilon-chains and (c) the genes responsible for the terminal cell division are not operated within 8-12 cell cycles, while K-562(S6) cells are fully induced to erythroid differentiation.
D002453:Cell Cycle; D002454:Cell Differentiation; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004900:Erythroblasts / Q000166:cytology; D005786:Gene Expression Regulation; D005914:Globins / Q000235:genetics*; D006427:Hemin / Q000494:pharmacology; D006801:Humans; D007938:Leukemia / Q000235:genetics*
D006427:Hemin; D005914:Globins