Hemostatic balance alterations in obese children.
Fibrinolytic response to venous occlusion and other clotting parameters were studied in 34 obese children and 16 controls. The obese children (mean age 9 2/12 years) had a mean overweight of 51.8% +/- 15.6, higher blood glucose and cholesterol levels, and increased baseline and glucose-induced insulinemia. However, baseline ELT did not differ significantly; ELT after 5 min venous occlusion was 203.2 +/- 110.9 min in the obese children and 114.7 +/- 67.9 min in the control group (p less than 0.01) with a mean percent decrease respectively of 14.9% and 29.2%. Poor fibrinolytic responders did not correlate with age, overweight, or metabolic indices. Lower levels of ATIII (p less than 0.01) and no changes in F VIII: C and F VIII: R Ag were also found in the obese. Furthermore, in a larger group of 84 prepubertal obese children (mean age 10 years; mean overweight 48.2%) and in 39 normal prepubertal children (mean age 10 4/12 years) we also studied platelet aggregation capacity according to Breddin. This parameter was altered in a high proportion of the obese children (p less than 0.05). The obese children were also poor fibrinolytic responders, similarly to obese adults, and exhibited early alteration of the clotting balance.
D000941:Antigens / Q000032:analysis; D000990:Antithrombin III / Q000032:analysis; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005169:Factor VIII / Q000032:analysis* / Q000276:immunology; D005260:Female; D005342:Fibrinolysis; D006487:Hemostasis; D006801:Humans; D007328:Insulin / Q000032:analysis; D008297:Male; D009765:Obesity / Q000097:blood*; D010974:Platelet Aggregation; D000979:alpha-2-Antiplasmin / Q000032:analysis; D014841:von Willebrand Factor
D000941:Antigens; D001786:Blood Glucose; D007328:Insulin; D000979:alpha-2-Antiplasmin; D014841:von Willebrand Factor; D000990:Antithrombin III; D005169:Factor VIII