Heme inhibition of ferrisiderophore reductase in Bacillus subtilis.
Heme was a noncompetitive inhibitor (apparent K(i) and K'(i) = 0.043 mM) of a ferrisiderophore reductase purified from Bacillus subtilis; protoporphyrin IX had no effect. The cellular level of heme may partly regulate the function of this reductase to yield a controlled flow of iron into metabolism.
D001412:Bacillus subtilis / Q000201:enzymology*; D006418:Heme / Q000494:pharmacology*; D007700:Kinetics; D009247:NADH, NADPH Oxidoreductases; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D006418:Heme; D010088:Oxidoreductases; D009247:NADH, NADPH Oxidoreductases; C024253:ferrisiderophore reductase