title: Systemic apomorphine reverses intrastriatal dopamine-induced contralateral deviation.
abstract: Contralateral deviation induced by unilateral injection of 25 micrograms or 100 micrograms dopamine into the dorsal CPU was reversed to ipsilateral deviation by apomorphine administered systemically (1 mg/kg s.c.) before, at the same time, or after the dopamine. Contralateral deviation to a unilateral intrastriatal injection of 6.25 micrograms apomorphine was also reversed to ipsilateral deviation by systemically administered apomorphine. No significant effects on postural deviation were found when a control solution was injected unilaterally into the striatum, followed by systemic apomorphine. Contralateral deviation to the unilateral intrastriatal dopamine injection continued following a further bilateral intrastriatal injection of either dopamine or apomorphine. These results suggest that intrastriatal dopamine indirectly affects sites receptive to dopamine outside the striatum.
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects*; D004298:Dopamine / Q000008:administration & dosage; D018492:Dopamine Antagonists; D007267:Injections; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
chemical_list: D018492:Dopamine Antagonists; D001058:Apomorphine; D004298:Dopamine