Similarity of secretory protein I from parathyroid gland to chromogranin A from adrenal medulla.
We have compared the amino acid and carbohydrate compositions, partial amino acid sequences, immunological crossreactivity, and physical properties of secretory protein I of the parathyroid gland and chromogranin A of adrenal gland. This comparison indicates that these proteins are similar molecules. Because secretory protein I is present in secretory granules containing parathormone and is cosecreted with the hormone, and because chromogranin A is contained within chromaffin granules and, likewise, is secreted with the catecholamines, the present observations raise the possibility that this class of protein plays a general role in hormone secretion or storage mechanisms.
D000313:Adrenal Medulla / Q000032:analysis*; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002135:Calcium-Binding Proteins / Q000302:isolation & purification*; D002417:Cattle; D002837:Chromaffin Granules / Q000032:analysis*; D002838:Chromaffin System / Q000032:analysis*; D053379:Chromogranin A; D002864:Chromogranins / Q000302:isolation & purification*; D003429:Cross Reactions; D005779:Immunodiffusion; D008970:Molecular Weight; D009419:Nerve Tissue Proteins / Q000302:isolation & purification*; D010280:Parathyroid Glands / Q000378:metabolism*; D013329:Structure-Activity Relationship
D000596:Amino Acids; D002135:Calcium-Binding Proteins; D053379:Chromogranin A; D002864:Chromogranins; D009419:Nerve Tissue Proteins