A primary screen for drugs to prevent transmission of Chagas's disease during blood transfusion.
This paper describes how Microslide tubes can be used as the basis for a quick, simple, inexpensive screen to test for compounds which might prevent the transmission of Chagas's disease as a result of blood transfusion. The test uses Trypanosoma cruzi-infected mouse blood and requires only very small amounts of compound. The screen identifies compounds known to be active against blood trypomastigotes in vitro at 4 degrees C, and is apparently free of false negative and positive results.
D000818:Animals; D001769:Blood / Q000469:parasitology; D014355:Chagas Disease / Q000517:prevention & control / Q000635:transmission*; D051379:Mice; D008815:Mice, Inbred Strains; D008826:Microbial Sensitivity Tests / Q000379:methods; D065227:Transfusion Reaction; D014344:Trypanocidal Agents / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects
D014344:Trypanocidal Agents