Ventilatory and cardiovascular effects of BHT 933 in volunteers.
In 12 healthy volunteers BHT 933 in doses of 5 and 10 mg had minimal effects on ventilation, a small fall in total volume occurred with the highest dose. BHT 933 (5 mg) reduced both systolic and diastolic blood pressure, but had little effect on autonomic reactivity tests, whereas the 10 mg dose reduced the response to these tests. Both doses of BHT 933 caused marked sedation. It is concluded that 5 mg BHT 933 orally presents the most suitable profile of activity for further studies into its usefulness as an anti-tussive and antihypertensive.
D000328:Adult; D001341:Autonomic Nervous System / Q000187:drug effects; D001381:Azepines / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D012119:Respiration / Q000187:drug effects*; D013997:Time Factors
D001381:Azepines; D006993:Hypnotics and Sedatives; D002245:Carbon Dioxide; C015603:azepexole