No effect of low-dose 1 alpha-hydroxycholecalciferol treatment on the renal function deterioration rate in long-term uraemic rabbits.
The development of renal function during 18 weeks of oral treatment with 1 alpha-hydroxycholecalciferol was investigated in rabbits with surgically induced chronic renal failure. Renal function was evaluated by the serum creatinine concentration and the 51Cr-EDTA clearance measured by the single injection technique. Three groups of uraemic rabbits on three different diets with high, medium and low content of calcium and phosphate were studied. The treatment with 0.02 microgram/kg/day of 1 alpha-hydroxycholecalciferol did not induce statistically significant changes in the serum concentrations of calcium or phosphate. Compared to placebo 1 alpha-hydroxycholecalciferol did not increase the deterioration rate of renal function in any of the three groups.
D000818:Animals; D002118:Calcium / Q000097:blood; D004492:Edetic Acid / Q000378:metabolism; D006887:Hydroxycholecalciferols / Q000009:adverse effects*; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D010710:Phosphates / Q000097:blood; D011817:Rabbits; D014511:Uremia / Q000188:drug therapy / Q000503:physiopathology*
D006887:Hydroxycholecalciferols; D010710:Phosphates; D004492:Edetic Acid; D002118:Calcium