title: Plasma catecholamines and response to exercise in 6-hydroxydopamine-treated dogs.
abstract: Plasma catecholamine (CA; picograms per millilitre) concentrations were measured simultaneously with heart rate (HR, beats per minute) during short-duration exercise, and with plasma glucose, lactate, and free fatty acid (FFA) concentrations (millimoles per litre) during long-duration exercise, in control dogs (N-dogs) and in sympathectomized dogs (S-dogs) with 6-hydroxydopamine (50 mg X kg-1). At rest, higher plasma CA in S-dogs (690 +/- 90 vs. 320 +/- 60) was associated with higher HR (126 +/- 3 vs. 90 +/- 5), plasma glucose (6.4 +/- 0.2 vs. 5.1 +/- 0.2), lactate (2.9 +/- 0.2 vs. 1.6 +/- 0.2), and FFA concentrations (1.08 +/- 0.11 vs. 0.81 +/- 0.11). During short-duration exercise a normal HR response in S-dogs (226 +/- 9 vs. 228 +/- 8) was dependent upon larger than normal plasma CA values (4280 +/- 680 vs. 1990 +/- 360). Metabolic adjustments to long-duration exercise were impaired in S-dogs as evidenced by the higher plasma glucose and lactate concentrations (8.2 +/- 0.5 and 5.5 +/- 0.3 vs. 6.4 +/- 0.4 and 4.6 +/- 0.3) and the lower plasma FFA concentration (0.66 +/- 0.16 vs. 1.20 +/- 0.09). These occurred despite a normal plasma CA response in S-dogs (6850 +/- 1450 vs. 8740 +/- 1680). Following chemical sympathectomy the adrenal medulla can compensate to ensure an adequate heart rate response to short-duration exercise, but not to ensure adequate metabolic adjustments to prolonged exercise.
mesh_terms: D000313:Adrenal Medulla / Q000502:physiology; D000818:Animals; D002395:Catecholamines / Q000097:blood*; D004285:Dogs; D006339:Heart Rate; D006892:Hydroxydopamines / Q000494:pharmacology; D016627:Oxidopamine; D005082:Physical Exertion; D013563:Sympathectomy, Chemical; D013564:Sympathetic Nervous System / Q000502:physiology*
chemical_list: D002395:Catecholamines; D006892:Hydroxydopamines; D016627:Oxidopamine