Elevated lipid peroxide levels in platelets of chronic ischemic heart disease patients.
A significantly higher platelet malondialdehyde-like material (MDA--LM) content after physical and N-ethylmaleimide (NEM) stimulation is found in chronic ischemic heart disease (CHD) patients when compared to the control group. In subjects under aspirin treatment "in vivo" (1 gr/day) no difference is found between CHD and control group. It is suggested that the enhanced amount of lipid peroxides in CHD platelets is produced by a cyclooxygenase-dependent mechanism. This enhanced platelet lipid peroxide production in CHD may be another platelet-dependent risk factor for atherosclerosis in these patients.
D000925:Anticoagulants / Q000494:pharmacology; D001241:Aspirin / Q000627:therapeutic use; D001792:Blood Platelets / Q000378:metabolism*; D002908:Chronic Disease; D002951:Citrates / Q000494:pharmacology; D019343:Citric Acid; D003327:Coronary Disease / Q000097:blood* / Q000188:drug therapy; D004492:Edetic Acid / Q000494:pharmacology; D006801:Humans; D008054:Lipid Peroxides / Q000096:biosynthesis / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D010812:Physical Stimulation
D000925:Anticoagulants; D002951:Citrates; D008054:Lipid Peroxides; D019343:Citric Acid; D008315:Malondialdehyde; D004492:Edetic Acid; D001241:Aspirin