Changes in the mucosa of colon conduits with particular reference to the risk of malignant change.
Intestinal suction biopsies were obtained in 15 infants and children with cutaneous colo-ureterostomies. The patients were subdivided into groups according to the length of time the conduit had been established, i.e. less than 5 years, 5 to 10 years, 10 to 15 years and over 15 years. The histological changes found were chronic inflammation with a dense infiltration of plasma cells and eosinophils. The changes were progressive and correlated with the length of time the conduit had been established. As persistent chronic inflammation is a precursor of malignancy, it seems likely that there is a risk of malignant change in these conduits. Regular follow-up of such patients is recommended and should include flexible fibreoptic endoscopy of the conduit.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003092:Colitis / Q000473:pathology; D003106:Colon / Q000473:pathology* / Q000601:surgery; D003110:Colonic Neoplasms / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D012306:Risk; D013997:Time Factors; D014513:Ureter / Q000601:surgery; D014547:Urinary Diversion / Q000009:adverse effects*