[Stabilizing action of alpha-tocopherol in postischemic damage to the hydroxylating system of the endoplasmic reticulum membranes of the rat liver].
Administration of alpha-tocopherol (50 mg/kg) as an oily emulsion into male rat stomach every 12 hours 2 days before and 3 days after local disturbance in liver circulation prevents postischemia (72 hours after resumption of circulation) repression of amidopyrine-N-demethylation, aniline-hydroxylation, NADP H-neotetrazolium reductase, NADP H oxidase, a decrease in the cytochrome P-450 level, as well as intensification of ascorbate-dependent lipid peroxidation of hepatocyte endoplasmic reticulum membranes. The protective effect of alpha-tocopherol is suggested to be due to its antioxidative and membrane-stabilizing properties.
D000818:Animals; D004721:Endoplasmic Reticulum / Q000187:drug effects* / Q000201:enzymology; D006900:Hydroxylation; D007425:Intracellular Membranes / Q000187:drug effects* / Q000201:enzymology; D007511:Ischemia / Q000188:drug therapy* / Q000201:enzymology; D008099:Liver / Q000098:blood supply* / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051381:Rats; D014810:Vitamin E / Q000627:therapeutic use*
D014810:Vitamin E
Stabiliziruiushchee deĭstvie al'fa-tokoferola pri postishmicheskom povrezhdenii gidroksiliruiushcheĭ sistemy membran éndoplazmaticheskogo retikuluma pecheni krys.