Evaluation of the factors influencing the radiosensitivity of mouse ascites tumors.
Factors influencing the radiosensitivity of the newly established mouse ascites tumor TMT-3 line were studied. In vivo radiosensitivity of the tumor cells decreased with the progression of the growth phase in mice. Oxygen depletion was the major cause of the decreased radiosensitivity. Polarographic measurement of the oxygen dissolved in suspension of various cell densities suggested that high cell density such as in the ascites might well cause severe hypoxia. Humoral factors in the ascites and cell-to-cell contact had no effect on tumor cell radiosensitivity when the influence of the repair of potentially lethal damage was excluded.
D000818:Animals; D002450:Cell Communication; D002460:Cell Line; D002470:Cell Survival; D004307:Dose-Response Relationship, Radiation; D005260:Female; D000860:Hypoxia; D066298:In Vitro Techniques; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000532:radiotherapy; D010100:Oxygen / Q000032:analysis; D010534:Peritoneal Neoplasms / Q000532:radiotherapy*; D011836:Radiation Tolerance; D013997:Time Factors
D010100:Oxygen