Adherence to human monocytes of red cells from autoimmune haemolytic anaemia and red cells sensitized with alloantibodies.
Red cells sensitized with autoantibodies are able to adhere in vitro to autologous monocytes and monocytes from healthy individuals. A direct relationship between the degree of sensitization and the percentage of rosettes was not observed, while such a correlation was found if red cells sensitized with anti-Rh alloantibodies were used. Sometimes the adherence of red cell from AIHA was observed although the sensitization was weaker than that of the control erythrocytes sensitized with anti-CD serum which did adhere to monocytes. In patients with AIHA some relation was found between the adherence assay, haemolysis in vivo and treatment with prednisone.
D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood / Q000276:immunology*; D001323:Autoantibodies; D004912:Erythrocytes / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007074:Immunoglobulin G / Q000145:classification; D007518:Isoantibodies; D009000:Monocytes / Q000378:metabolism*; D012204:Rh-Hr Blood-Group System / Q000276:immunology; D012397:Rosette Formation
D001323:Autoantibodies; D007074:Immunoglobulin G; D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System