Soybean lipoxygenase-1 inhibition by ketone hydrazones.
Acetone phenylhydrazone has recently been discovered as a predominant inhibitor of arachidonic acid lipoxygenase in platelets [1]. We found that besides this compound a variety of hydrazones derived from other ketones and hydrazines exhibited similar or more interesting inhibition patterns both against soybean lipoxygenase and rat renal prostaglandin synthetase. Depending on their molecular structure, relatively selective inhibitors of the two arachidonate peroxidation pathways are introduced which may be useful tools for further investigation of the fatty acid oxygenation cascade.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors; D006835:Hydrazones / Q000494:pharmacology*; D066298:In Vitro Techniques; D007659:Ketones / Q000494:pharmacology*; D007679:Kidney Medulla / Q000201:enzymology; D016859:Lipoxygenase Inhibitors; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013025:Glycine max / Q000201:enzymology*
D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D006835:Hydrazones; D007659:Ketones; D016859:Lipoxygenase Inhibitors; D016718:Arachidonic Acid