title: Effect of various oral dose levels of a trimethoprim/sulphadiazine mixture on Bordetella bronchiseptica infection and on the proliferation of trimethoprim-resistant faecal coliforms in pigs.
abstract: When a 1:5 mixture of trimethoprim (TMP) and sulphadiazine was fed to pigs intra-nasally infected with bordetella bronchiseptica, 10 mg/kg/day was shown to be highly effective in suppressing the organism. This dose level had little effect on numbers of TMP-resistant coliforms in faeces, but oral doses of 30 mg/kg/day eventually selected a resistant population. It is suggested that the proliferation of resistant coliforms would be minimized by administration of the lowest oral dose rates of antibacterial drugs compatible with efficacy.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001885:Bordetella Infections / Q000188:drug therapy / Q000662:veterinary*; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects / Q000254:growth & development*; D005243:Feces / Q000382:microbiology; D013411:Sulfadiazine / Q000008:administration & dosage* / Q000627:therapeutic use; D013552:Swine / Q000382:microbiology; D013553:Swine Diseases / Q000188:drug therapy*; D014295:Trimethoprim / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D013411:Sulfadiazine; D014295:Trimethoprim