title: Blood cells and their role in regeneration. I. Changes in circulating blood cell counts during forelimb regeneration.
abstract: The possible role of leukocytes in regeneration was examined through the evaluation of quantitative changes in circulating blood cell counts during forelimb regeneration in adult newts. Leukocyte counts declined during the first 2 weeks, then returned to preamputational levels. Thrombocytes were also depressed (40-67%) throughout the progressive stages (9-30 days). In addition, lymphocytes were reduced, especially during the preblastemic phase (less than 15 days). In contrast, neutrophils were increased immediately following wound healing and during the differentiation stages, but were otherwise unchanged. These variations appear to reflect physiological changes occurring during regeneration and are consistent with a potential role for leukocytes in regeneration.
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D001773:Blood Cells / Q000502:physiology*; D005121:Extremities / Q000502:physiology; D012455:Salamandridae; D014945:Wound Healing