Studies on biosynthesis of pentalenolactone. V isolation of deoxypentalenylglucuron.
Deoxypentalenylglucuron was isolated from the culture broths of three different strains, such as Streptomyces omiyaensis, S. albofaciens and S. viridifaciens. The structure of deoxypentalenylglucuron has been determined by 1H and 13C NMR, mass spectroscopy and by chemical correlation to be an oxidation product of pentalenene 1. Deoxypentalenylglucuron (1) has some antitumor activity against Sarcoma 180 in mice.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D051379:Mice; D010084:Oxidation-Reduction; D012510:Sarcoma 180 / Q000188:drug therapy; D012717:Sesquiterpenes / Q000096:biosynthesis / Q000302:isolation & purification / Q000627:therapeutic use; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D012717:Sesquiterpenes; C017996:arenaemycin E; C037744:deoxypentalenylglucuron