The effect of levonorgestrel and estrone rods on male reproductive function.
The effect on spermatogenesis of the implantation of six rods containing levonorgestrel and three estrone rods was studied in seven volunteers aged 32-40, with normal pre-treatment spermiogram. None of the subjects achieved azoospermia. The lowest sperm count was below 1 million/ml in three subjects and below 12 million/ml in the other four. Plasma FSH and testosterone were severely depressed during the study, but LH was only transiently depressed for the first two months. Four subjects recovered pre-treatment sperm counts in spite of the FSH levels below 1.5 mIU/ml and testosterone levels below 1 ng/ml, which is contradictory to the current concept on hormonal regulation of spermatogenesis.
D000328:Adult; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage / Q000494:pharmacology; D003692:Delayed-Action Preparations; D004357:Drug Synergism; D004970:Estrone / Q000008:administration & dosage / Q000494:pharmacology*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D016912:Levonorgestrel; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009644:Norgestrel / Q000008:administration & dosage / Q000494:pharmacology*; D013076:Sperm Count; D013091:Spermatogenesis / Q000187:drug effects*; D013739:Testosterone / Q000097:blood
D003277:Contraceptives, Oral, Combined; D003692:Delayed-Action Preparations; D004970:Estrone; D009644:Norgestrel; D013739:Testosterone; D016912:Levonorgestrel; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone