Inhibition of nocturnal gastric secretion in normal human volunteers by misoprostol: a synthetic prostaglandin E1 methyl ester analog.
Misoprostol (SC-29333) is a synthetic prostaglandin E1 analog that has been found to be a potent inhibitor of gastric secretion in animals. Nocturnal gastric antisecretory activity of misoprostol, in tablet form, was studied in 16 adult volunteers, under basal condition. The study was a randomized, double-blind, cross-over, comparison of placebo, and three graded doses of misoprostol (50, 100, and 200 micrograms). Misoprostol exhibited a statistically significant inhibition of total acid output only at the 200 micrograms dose and this inhibition was maintained for 3 h postadministration of the drug. The antisecretory effects of misoprostol were characterized by suppression of H+ ion but not of the volume of gastric secretion. No untoward effects were noted in the volunteers. As a consequence of the gastric antisecretory effects, the present studies indicate that misoprostol is a promising therapeutic agent for the treatment of peptic ulcer.
D000328:Adult; D004311:Double-Blind Method; D004341:Drug Evaluation; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D008297:Male; D016595:Misoprostol; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D011897:Random Allocation; D013997:Time Factors
D011459:Prostaglandins E, Synthetic; D016595:Misoprostol