title: Effect of strenuous exercise on serum lithium level in man.
abstract: The authors examined the effect of strenuous exercise on the serum lithium levels of four healthy, conditioned athletes who were stabilized on lithium carbonate for 7 days and who ran a 20-km race under hot, humid conditions. The subjects became substantially dehydrated during the race, and their serum lithium levels decreased, suggesting that sweat lithium loss may be substantial. (The sweat-to-serum ratio for lithium exceeded that for sodium by a factor of 4.) The authors conclude that contrary to widely held belief, heavy sweating may not increase the risk of lithium intoxication.
mesh_terms: D000328:Adult; D001835:Body Weight; D003681:Dehydration / Q000097:blood; D006801:Humans; D008094:Lithium / Q000008:administration & dosage / Q000032:analysis / Q000097:blood* / Q000506:poisoning; D016651:Lithium Carbonate; D008297:Male; D005082:Physical Exertion; D012964:Sodium / Q000032:analysis / Q000097:blood; D013542:Sweat / Q000032:analysis; D013546:Sweating
chemical_list: D016651:Lithium Carbonate; D008094:Lithium; D012964:Sodium