Long term experiment of perfluorochemicals using rabbits.
Morphological changes six months of two years after the administration of Perfluorochemicals (PFC) in rabbits injected with a large amount of PFC (67 mg/kg) have already been reported by Ohnishi and Kitazawa (1979, 1980, and 1981). In this paper, the authors report on the persistence of large numbers of foamy cells in the liver, spleen and lymph nodes and many in the kidneys, lung and bone marrow, up to two years after administration. Quantitative analysis of PFC in various organs showed that it was retained. The liver revealed progressive fibrosis surrounding the foamy cells in or around the Glisson's sheath.
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D004338:Drug Combinations / Q000378:metabolism / Q000633:toxicity; D005466:Fluorocarbons / Q000378:metabolism / Q000633:toxicity*; D005487:Foam Cells / Q000187:drug effects*; D006895:Hydroxyethyl Starch Derivatives; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008264:Macrophages / Q000187:drug effects*; D008297:Male; D011817:Rabbits; D013154:Spleen / Q000473:pathology; D013997:Time Factors; D014018:Tissue Distribution
D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination