[Fibronectin: an important component of bronchoalveolar defense?].
Fibronectin, an important nonimmune opsonin, was found in the bronchoalveolar lavage fluid (BAL) of 29 healthy volunteers using a sensitive radioimmunoassay. The mean FN content was 9.5 micrograms FN/mg albumin. The BAL FN was immunologically and functionally similar to plasma FN and showed opsonic activity which increased uptake of gelatin coated beads by human alveolar macrophages. Therefore, BAL contains a functionally intact FN which may serve as an opsonin for the clearance of particles and microorganisms in the terminal airways.
D001980:Bronchi / Q000032:analysis*; D005122:Exudates and Transudates / Q000032:analysis; D005353:Fibronectins / Q000032:analysis* / Q000494:pharmacology; D006801:Humans; D010587:Phagocytosis / Q000187:drug effects; D011650:Pulmonary Alveoli / Q000032:analysis*; D011863:Radioimmunoassay; D007507:Therapeutic Irrigation
D005353:Fibronectins
Fibronectin: ein wichtiger Bestandteil der bronchoalveolären Abwehr?