title: Comparative gene mapping: murine lambda light chain genes are located in region cen to B5 of mouse chromosome 16 not homologous to human chromosome 21.
abstract: We have mapped the genes for murine immunoglobulin lambda light chains to the region of chromosome 16 proximal to band B5 by hybridizing a cDNA probe for gamma light chains to the DNA of a series of hybrid clones made between mouse fibroblasts carrying Searle's translocation, T(X;16)16H, and Chinese hamster cells. Based on homology, we predict that the human Ig gamma gene (IGL) will map to the proximal two-thirds of HSA 22.
mesh_terms: D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002902:Chromosomes, Human, 16-18; D006224:Cricetinae; D003412:Cricetulus; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans; D006822:Hybrid Cells / Q000648:ultrastructure; D007147:Immunoglobulin Light Chains / Q000235:genetics*; D007146:Immunoglobulin lambda-Chains / Q000235:genetics*; D051379:Mice / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D013045:Species Specificity
chemical_list: D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains