title: [Comparison of the antimicrobial activity of pefloxacin (1589 RB), nalidixic acid and flumequin (author's transl)].
abstract: The MIC of the four quinolones were determined for 839 bacterial isolates. The mean in vitro activity of pefloxacin against strains susceptible to nalidixic acid was found to be four times greater than flumequin, eight times greater than pipemidic acid, sixteen times greater than nalidixic acid. On resistant strains pefloxacin, at levels lower than 32 micrograms/ml, remained active against 67 go 100 per cent of the strains as a function of bacterial species. Streptocoques D and Pseudomonas aeruginosa, resistant to other quinolones, were found to be susceptible to pefloxacin.
mesh_terms: D000892:Anti-Infective Agents, Urinary / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D024841:Fluoroquinolones; D009268:Nalidixic Acid / Q000494:pharmacology; D015366:Pefloxacin; D010876:Pipemidic Acid / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011804:Quinolines / Q000494:pharmacology; D011807:Quinolizines / Q000494:pharmacology
chemical_list: D000892:Anti-Infective Agents, Urinary; D024841:Fluoroquinolones; D011804:Quinolines; D011807:Quinolizines; D015366:Pefloxacin; D009268:Nalidixic Acid; D010876:Pipemidic Acid; C012976:flumequine
vernacular_title: Activité antibactérienne comparée in vitro de la péfloxacine (1589 RB), de l'acide nalidixique, de l'acide pipémidique et de la fluméquine.