Determination of aspartate aminotransferase isoenzymes in hepatic diseases--preliminary findings.
The study sought to establish a relationship between the AST isoenzyme levels in serum and degree of hepatic damage, by using a new and simple immunochemical method for the differential determination of the isoenzymes. Sixty-nine patients with various hepatic diseases were studied. During hepatic damage, cytoplasmic isoenzyme (s-AST) is found in greater quantities than mitochondrial isoenzyme (m-AST), but the m-AST level increases to a greater extent in acute liver diseases. However, m-AST in alcoholic hepatitis is higher than expected from the total AST (t-AST) values. The ratio of m-AST to t-AST seems to discriminate alcoholic hepatitis from other liver diseases.
D000328:Adult; D001219:Aspartate Aminotransferases / Q000097:blood*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008107:Liver Diseases / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000201:enzymology
D007527:Isoenzymes; D001219:Aspartate Aminotransferases