Circulating immune complexes in paroxysmal nocturnal hemoglobinuria.
Circulating immune complexes were investigated in sera of 13 patients with paroxysmal nocturnal hemoglobinuria. A significant inhibition was observed in the complement-dependent rosette formation (EAC) in 6 cases; 2 patients presented an increased anticomplementary activity; antilymphocyte antibodies were demonstrated in 2 patients. The levels of C3d and immunoconglutinins were also increased; there were no differences in the total hemolytic complement between patients and normal controls. There was a significant correlation between C3d and immunoconglutinins with the inhibition of the EAC rosette formation test. These results provide evidence for the presence of circulating immune complexes in paroxysmal nocturnal hemoglobinuria.
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000032:analysis*; D000961:Antilymphocyte Serum; D003176:Complement C3 / Q000032:analysis; D003168:Complement Fixation Tests; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012397:Rosette Formation
D000936:Antigen-Antibody Complex; D000961:Antilymphocyte Serum; D003176:Complement C3; D003165:Complement System Proteins