A new Cd-115 leads to In-115m radionuclide generator.
A new column-type Cd-115 leads to In- 115m generator has been developed by adsorbing CdI4(-2) on an anion-exchange resin and eluting the In-115m with 0.05 M HCl. The In-115m yield of the prototype column is 90% in a volume of 3 ml, with Cd-115 breakthrough of less than 3 X 10(-4)%. Over thirty generators with up to 40 mCi of activity have been produced using components of a commercial Mo-99 leads to Tc-99m generator system; they behaved like the prototype. In-115m oxine prepared from these generators has been used to label canine platelets and to image an induced canine thrombus in vivo.
D000818:Animals; D001792:Blood Platelets; D002104:Cadmium; D004285:Dogs; D007204:Indium; D007553:Isotope Labeling; D011868:Radioisotopes; D011876:Radionuclide Generators / Q000295:instrumentation; D011877:Radionuclide Imaging; D013924:Thrombophlebitis / Q000000981:diagnostic imaging
D011868:Radioisotopes; D002104:Cadmium; D007204:Indium