title: [Comparative study, on healthy volunteers, of the bioavailability of 2 pharmaceutical formulations of oral cofosfolactamines. Trials between subjects].
abstract: The relative bioavailability of two drug-product formulations, aqueous suspension and tablets, of a fixed-dose combination of fosfomycin with amoxicillin (cophosfolactamine) has been comparatively studied in five healthy volunteers by means of a randomized within subjects experimental design. The plasmatic concentrations were consistent with the in vitro synergistic effects. The liquid formulation has a significantly higher bioavailability than that of the tablets.
mesh_terms: D000328:Adult; D000658:Amoxicillin / Q000097:blood / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001682:Biological Availability; D004338:Drug Combinations / Q000378:metabolism; D004357:Drug Synergism; D005260:Female; D005578:Fosfomycin / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D013535:Suspensions; D013607:Tablets
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D013535:Suspensions; D013607:Tablets; D005578:Fosfomycin; D000658:Amoxicillin; C037388:cofosfolactamine
vernacular_title: Studio comparativo su volontari sani della biodisponibilità di due formulazioni farmaceutiche di una cofosfolattamina orale: Esperienza entro soggetti.