Familial paroxysmal dystonic choreoathetosis and response to alternate-day oxazepam therapy.
A patient with familial paroxysmal dystonic choreoathetosis (FPDC) who was only transiently improved on daily benzodiazepine therapy showed sustained benefit from a regimen of alternate-day oxazepam therapy. Our findings confirm that FPDC is responsive to benzodiazepine therapy and suggest that an alternate-day dosing schedule, using a short-acting benzodiazepine, may minimize receptor down regulation and thereby sustain the therapeutic effect.
D001264:Athetosis / Q000188:drug therapy* / Q000235:genetics; D002819:Chorea / Q000188:drug therapy* / Q000235:genetics; D004421:Dystonia / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010076:Oxazepam / Q000008:administration & dosage*
D010076:Oxazepam