Comparative gene mapping: murine lambda light chain genes are located in region cen to B5 of mouse chromosome 16 not homologous to human chromosome 21.
We have mapped the genes for murine immunoglobulin lambda light chains to the region of chromosome 16 proximal to band B5 by hybridizing a cDNA probe for gamma light chains to the DNA of a series of hybrid clones made between mouse fibroblasts carrying Searle's translocation, T(X;16)16H, and Chinese hamster cells. Based on homology, we predict that the human Ig gamma gene (IGL) will map to the proximal two-thirds of HSA 22.
D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002902:Chromosomes, Human, 16-18; D006224:Cricetinae; D003412:Cricetulus; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans; D006822:Hybrid Cells / Q000648:ultrastructure; D007147:Immunoglobulin Light Chains / Q000235:genetics*; D007146:Immunoglobulin lambda-Chains / Q000235:genetics*; D051379:Mice / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D013045:Species Specificity
D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains