[Effect of retinoids on the development and growth of experimental tumors].
The ability of six retinoids to inhibit cancer growth was tested on mice with Lewis lung carcinoma, PRG and RSM-5 tumors. It was shown that all tumors possess individual sensitivities to retinoids. The most effective substances were: methyl retinoate (all-trans and 13-cis isomers) and a retinoid with a small side chain and an oxidated beta-iononic ring (substance 3). Each of those three retinoids was tested for an ability to prevent methylcholanthrene-induced carcinogenesis in the skin. All-trans methylretinoate had the most pronounced effect; however, it was the most toxic, too.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000627:therapeutic use
D014801:Vitamin A
Vliianie retinoidov na razvitie i rost éksperimental'nykh opukhleĭ.