Effect of reserpine on relaxant responses of canine femoral arterial strips.
1. We studied relaxant responses to adenosine, glyceryl trinitrate, and hydralazine in control (n=5) and reserpine pretreated (1 mg/kg i.m., 24 h prior; n=5) canine femoral arterial strips contracted with noradrenaline. 2. Reserpine did not alter contractile responses to noradrenaline. 3. Reserpine pretreated tissues were supersensitive to glyceryl trinitrate, but not to adenosine or hydralazine.
D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D005263:Femoral Artery / Q000187:drug effects; D006830:Hydralazine / Q000494:pharmacology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D005996:Nitroglycerin / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology*
D006830:Hydralazine; D012110:Reserpine; D005996:Nitroglycerin; D000241:Adenosine; D009638:Norepinephrine