Methyl beta-glycosides of N-acetyl-6-O-(omega-aminoacyl)muramyl-L-alanyl-D-isoglutamines, and their conjugates with meningococcal group C polysaccharide.
Spacer arms 2.1-3.7 nm (21-37 A) long were prepared, and coupled with the methyl beta-glycoside of N-acetylmuramyl-L-alanyl-D-isoglutamine benzyl ester, to give blocked 6-acylates. Deprotection was effected with palladium chloride and triethyl-silane. Chemical conjugates of MDP-meningococcal group C polysaccharide were then synthesized, in attempts to enhance the immunogenicity of the polysaccharide antigen.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives*; D007202:Indicators and Reagents; D008759:Methylglycosides / Q000138:chemical synthesis*; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; D008759:Methylglycosides; D011135:Polysaccharides, Bacterial; C037676:meningococcal group C polysaccharide; D000119:Acetylmuramyl-Alanyl-Isoglutamine