Contents and compositions of glycosaminoglycans in different sites of the human hip joint cartilage.
The distribution of glycosaminoglycans (GAGs) in different functional regions (weight-bearing and nonweight-bearing portions) of the human hip joint cartilage was studied. The results obtained were as follows: (1) Weight-bearing cartilage contains larger amounts of GAGs than nonweight-bearing, cartilage. (2) Weight-bearing cartilage contains keratan sulphate in higher ratio to chondroitin sulphate than nonweight-bearing cartilage. (3) The differences in content and composition of GAGs between the weight-bearing and nonweight-bearing portions are more pronounced in the femoral head than in the acetabulum. The preliminary analyses showed that the chondroitin sulphate from the acetabular cartilage contained exclusively 6-sulphated disaccharide units and there was some heterogeneity in keratan sulphate.
D000077:Acetabulum / Q000032:analysis; D000368:Aged; D002358:Cartilage, Articular / Q000032:analysis*; D002809:Chondroitin Sulfates / Q000032:analysis; D005270:Femur Head / Q000032:analysis; D006025:Glycosaminoglycans / Q000032:analysis*; D006601:Hexoses / Q000032:analysis; D006621:Hip Joint / Q000032:analysis*; D006801:Humans; D007632:Keratan Sulfate / Q000032:analysis; D008875:Middle Aged; D014574:Uronic Acids / Q000032:analysis
D006025:Glycosaminoglycans; D006601:Hexoses; D014574:Uronic Acids; D002809:Chondroitin Sulfates; D007632:Keratan Sulfate