Differentiation of benign monoclonal gammopathy and smouldering multiple myeloma from frank myeloma.
Circulating immunoglobulin (Ig) secreting cells of each type of the different Ig classes were enumerated using a reverse haemolytic plaque assay in nine subjects with the pre-clinical phase of IgG myeloma (six with benign monoclonal gammopathy and three with smouldering multiple myeloma). A shift in the ratio of IgG kappa to IgG lambda secreting cells without a significant increase in the total number of IgG secreting cells, that is the number of IgG kappa plus IgG lambda secreting cells, was a constant feature noted in every subject.
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006462:Hemolytic Plaque Technique; D006801:Humans; D006942:Hypergammaglobulinemia / Q000175:diagnosis* / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000276:immunology
D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains