title: Effects of androgenic-anabolic steroids on neuromuscular power and body composition.
abstract: The effects of androgenic-anabolic steroids on neuromuscular power and body composition were studied in nine volunteers experienced with progressive-resistance weight training. By use of double-blind procedures, testosterone cypionate, nandrolone decanoate, and sesame oil (placebo) were administered in a repeated-measures design that counterbalanced treatment order. Duration of each treatment condition was 3 wk. Supplemental protein was provided, and dietary records were maintained throughout the study. Subjects were trained with progressive-resistance weight-training exercises. Isokinetic dynamometer testing revealed that peak torque output was not significantly changed between treatments in 7 out of 10 isolated-joint actions. The hydrostatic weighing results revealed insignificant differences in lean body mass and percent body fat. Significant changes in some treatment means of three peak torque output tests were insufficient to identify any consistent treatment alterations. Since protein and caloric intake was sufficient to elicit anabolic effects from the steroid treatments and weight-training program, the lack of significant results could not be attributed to dietary considerations. Subjects reported subjective feelings of increased strength after administration of anabolic agents, which may partially account for their widespread use. In conclusion, anabolic steroids did not substantially change body composition or the objective power measurements used in this study.
mesh_terms: D000328:Adult; D045930:Anabolic Agents / Q000494:pharmacology*; D000728:Androgens / Q000494:pharmacology*; D001823:Body Composition / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009132:Muscles / Q000187:drug effects* / Q000502:physiology; D009469:Neuromuscular Junction / Q000502:physiology*
chemical_list: D045930:Anabolic Agents; D000728:Androgens