Selective neurotoxin lesions of the lateral septum: changes in social and aggressive behaviours.
Bilateral microinjection of 5,7-dihydroxytryptamine into the lateral septum resulted in a behavioural profile in the Social Interaction test of anxiety similar to that seen after chronically-administered benzodiazepines. In contrast, bilateral microinjection of 6-hydroxydopamine into this locus did not alter the profile of rats tested in this model. In a colony-intruder model of aggression, the 5,7-dihydroxytryptamine lesioned rats showed decreased dominance, while the 6-hydroxydopamine lesioned rats showed increased dominance and reduced subordination. The results suggest that lateral septal 5-hydroxytryptamine, but not catecholamines, is important in the control of anxiety, whereas both lateral septal 5-hydroxytryptamine and catecholamines are involved in the control of aggression.
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology*; D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D004102:Dihydroxytryptamines / Q000494:pharmacology*; D007839:Functional Laterality; D006179:Gyrus Cinguli / Q000502:physiology; D006801:Humans; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D009498:Neurotoxins; D016627:Oxidopamine; D051381:Rats; D012919:Social Behavior / Q000187:drug effects*
D004102:Dihydroxytryptamines; D006892:Hydroxydopamines; D009498:Neurotoxins; D015116:5,7-Dihydroxytryptamine; D016627:Oxidopamine