title: [The effect of intermittent hydrogen chloride exposure on the lung function of the guinea pig].
abstract: 23 guinea pigs were exposed to 15 mg/m3 HCl gas 5 days/week, 2 hours daily, for 7 weeks. 15 animals served as controls. From the 5th day of exposure, the following lung function parameters were evaluated in anaesthetised animals: VT, fR, minute volume, TGV, Vmax, R1, Rw, Rrs, Cl, Cw, Crs, delta Poes/VT, hemoglobin, SaO2, PaO2, PaCO2, pH, SBC, BE. These measurements showed no differences between HCl-exposed animals and controls. Histological examination of the lungs revealed no changes which could be attributed to HCl-exposure. This study relates to the important question whether lung damage can be induced by industrially produced, intermittent high levels of HCl in the environment.
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004781:Environmental Exposure; D006168:Guinea Pigs; D006851:Hydrochloric Acid / Q000633:toxicity*; D008168:Lung / Q000187:drug effects*; D008176:Lung Volume Measurements; D008297:Male; D010100:Oxygen / Q000097:blood
chemical_list: D002245:Carbon Dioxide; D006851:Hydrochloric Acid; D010100:Oxygen
vernacular_title: Der Einfluss einer intermittierenden Chlorwasserstoffexposition auf die Lungenfunktion des Meerschweinchens.