Induction of hepatic UDP-glucuronyltransferase by oral methaqualone consumption.
Repeated oral administration of methaqualone (100 mg/kg/day) to rats for 6 consecutive days evoked approximately two and a half fold increase in p-nitrophenol glucuronidation by hepatic microsomes. Interestingly, the magnitude of UDP-glucuronyltransferase stimulation by methaqualone, when assessed in crude liver homogenate, was comparable to that obtained with isolated microsomes.
D000284:Administration, Oral; D000818:Animals; D004790:Enzyme Induction; D014453:Glucuronosyltransferase / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008702:Methaqualone / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D008702:Methaqualone; D014453:Glucuronosyltransferase