Immunopharmacologic properties of 1,6-bis[2-(diethylamino)ethoxy]xanthen-9-one dihydrochloride (Wy-15297).
When tested in a series of immunopharmacologic assays, the interferon inducer, WY-15297, was shown to lack activity in early vascular and humoral phases of the inflammatory response, while it was quite effective against the immunologic phase. The profile of activity of Wy-15927 was, however, unlike those previously described for reference antiinflammatory and immunosuppressive drugs and this may represent one of a new class of immunopharmacologic agents capable of selectively modulating the lymphoreticular system.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000917:Antibody Formation / Q000187:drug effects; D004285:Dogs; D006168:Guinea Pigs; D007109:Immunity / Q000187:drug effects*; D007111:Immunity, Cellular / Q000187:drug effects; D066298:In Vitro Techniques; D007369:Interferon Inducers / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D014966:Xanthenes / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007369:Interferon Inducers; D014966:Xanthenes; C066361:Wy 15297