title: Genetic control of drug resistance: assignment of ama-1 to Chinese hamster chromosome 7, confirmation of assignment of genes coding for TK, GALK, and ACP to chromosome 7, and tentative assignment of TPI to chromosome 8.
abstract: The gene which specifies a subunit of RNA polymerase II, ama-1, is assigned to chromosome 7 in the Chinese hamster. The assignment of genes coding for TK, GALK, and ACP to chromosome 7 is confirmed, with a provisional regional assignment of TK and GALK to 7q. On the basis of one clone with six subclones, a provisional assignment of TPI to Chinese hamster chromosome 8 is made. With the assignment of tk and ama-1 to chromosome 7 in the CHO cell line Ama1, this chromosome is shown to have two selectable markers.
mesh_terms: D000135:Acid Phosphatase / Q000235:genetics*; D000228:Adenine Phosphoribosyltransferase / Q000235:genetics; D000818:Animals; D002871:Chromosome Banding; D002875:Chromosomes / Q000502:physiology*; D006224:Cricetinae; D003412:Cricetulus; D004351:Drug Resistance; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000201:enzymology; D005686:Galactokinase / Q000235:genetics*; D005796:Genes; D006822:Hybrid Cells / Q000201:enzymology; D007621:Karyotyping; D007739:L Cells / Q000201:enzymology; D051379:Mice; D013937:Thymidine Kinase / Q000235:genetics*
chemical_list: D000228:Adenine Phosphoribosyltransferase; D013937:Thymidine Kinase; D005686:Galactokinase; D000135:Acid Phosphatase