title: 2,3,5-Trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone (AA861), a selective inhibitor of the 5-lipoxygenase reaction and the biosynthesis of slow-reacting substance of anaphylaxis.
abstract: 2,3,5-Trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone (AA861) inhibited 5-lipoxygenase of guinea pig peritoneal polymorphonuclear leukocytes (ID50, 0.8 microM). The inhibition was of competitive type. 12-Lipoxygenases and fatty acid cyclooxygenase were not affected below 10 microM. The formation of slow-reacting substance of anaphylaxis by the sensitized guinea pig lung was almost fully suppressed by the compound at 10 microM.
mesh_terms: D000818:Animals; D001091:Arachidonate Lipoxygenases; D016227:Benzoquinones; D001667:Binding, Competitive; D006168:Guinea Pigs; D007700:Kinetics; D008084:Lipoxygenase / Q000097:blood; D016859:Lipoxygenase Inhibitors; D009504:Neutrophils / Q000201:enzymology*; D011809:Quinones / Q000494:pharmacology*; D013189:SRS-A / Q000096:biosynthesis* / Q000097:blood; D013329:Structure-Activity Relationship
chemical_list: D016227:Benzoquinones; D016859:Lipoxygenase Inhibitors; D011809:Quinones; D013189:SRS-A; C036837:2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone; D001091:Arachidonate Lipoxygenases; D008084:Lipoxygenase