[Hypophyseal response to LH-RH test, following use of non-aromatisable androgen on women with normal menstruation cycle (author's transl)].
Women with normal menstruation cycle were followed up for the hypophyseal response to LH-RH tests, following application of a non-aromatisable androgen. The purpose was to check up a hypothesis according to which hyperandrogenism was in no causative relationship with anovulation. The LH-RH test was applied twice to ten women with transsexualism who had an ovulatory menstruation cycle, one of them being used for control and the other immediately following four-day application of non-aromatisable androgen Ultandren (fluoxymesterone), Ciba, in the early follicular maturation phase of the menstruation cycle. The dose was 40 mg per diem, with the route of administration being oral. Hypophyseal reaction was assessed through the difference between the original value and the maximum of FSH and LH rise (radio-immunological measurement), 45 minutes following intravenous injection of 100 micrograms of LH-RH. Assessment was based on the phase-t test. The average differences between gonadotrophin values in the control cycle, on the one hand, and in the cycle under the impact of fluoxymesterone, on the other, were verified by simple t-test and pairs test. -- Non-aromatisable androgen fluoxymesterone did not depress with significance the depletion of either gonadotrophin in the women treated. Hypophyseal reaction to the LH-RH test was not substantially influenced by increased levels of non-aromatisable androgen. These results are likely to reinforce the doubts of the authors in the presence of an unambiguous direct causative relationship between hyperandrogenism and anovulation.
D000293:Adolescent; D000328:Adult; D000728:Androgens / Q000494:pharmacology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008598:Menstruation / Q000187:drug effects*; D010902:Pituitary Gland / Q000187:drug effects*
D000728:Androgens; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Die Reaktion der Hypophyse im LH-RH-Test nach Anwendung eines nichtaromatisierbaren Androgens bei frauen mit nomalem Menstruationszyklus.