title: The human HLA-DR antigens are encoded by multiple beta-chain loci.
abstract: Monoclonal antibodies have been used to isolate and characterize human HLA-DR antigens from human B cell lines. Using sequential immunodepletion experiments, several subsets of DR antigens have been identified. Partial amino-terminal amino acid sequencing has identified these subsets as DR molecules with sequences homologous to the murine I-E alloantigens. In addition, sequence data provide evidence for primary structural differences in the DR beta-chains of two of the subsets. These results provide primary structural evidence for the presence of multiple DR beta-chain loci.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D001667:Binding, Competitive; D055598:Chemical Phenomena; D002621:Chemistry; D002874:Chromosome Mapping; D003429:Cross Reactions; D005802:Genes, MHC Class II; D006684:HLA-DR Antigens; D006649:Histocompatibility Antigens / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000145:classification / Q000276:immunology; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D000911:Antibodies, Monoclonal; D006684:HLA-DR Antigens; D006649:Histocompatibility Antigens; D000949:Histocompatibility Antigens Class II; C024138:I-E-antigen