[Changes in the size and properties of lipoprotein particles in the extracellular medium during incubation of low density lipoproteins with human fibroblasts].
Electron microscopy, disc electrophoresis in polyacrylamide gel, and microzonal electrophoresis on acetate cellulose were used to examine the changes in the properties of low density lipoproteins (LDL) in extracellular medium during incubation with human fibroblasts. It was established that as a result of LDL interaction with fibroblasts there appeared lipoprotein particles less in size, with higher aggregation ability and electrophoretic mobility. The data obtained indicate that LDL undergo physicochemical changes due to non-specific interaction with fibroblasts.
D002478:Cells, Cultured; D004589:Electrophoresis, Disc; D004622:Embryo, Mammalian; D005110:Extracellular Space / Q000032:analysis*; D005347:Fibroblasts; D006801:Humans; D008077:Lipoproteins, LDL / Q000032:analysis*; D008854:Microscopy, Electron
D008077:Lipoproteins, LDL
Izmenenie razmera i svoĭstv lipoproteidnykh chastits vo vnekletochnoĭ srede pri inkubatsii lipoproteidov nizkoi plotnosti s fibroblastami cheloveka.