Temperature dependent conformational changes in calmodulin.
Calcium bound calmodulin undergoes a reversible conformational change in the temperature range (22-28 degrees C). The transition temperature depends upon the concentration of calcium bound to calmodulin. The transition occurs at higher temperature (28 degrees C) in fully Ca2+ bound calmodulin as compared to those with lower Ca2+ concentrations (22 degrees C). The sequence of filling the four Ca2+ binding sites is different for the two temperature dependent conformers.
D001665:Binding Sites; D002118:Calcium / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism*; D011487:Protein Conformation; D013050:Spectrometry, Fluorescence; D013696:Temperature
D002135:Calcium-Binding Proteins; D002147:Calmodulin; D002118:Calcium