Enterocolitis in piglets caused by Cryptosporidium sp. purified from calf faeces.
Twelve gnotobiotic piglets were dosed with a bacteria-free calf faecal homogenate which contained Cryptosporidium oocysts. The infection induced severe enterocolitis in piglets when inoculated at 1 day of age, moderate diarrhoea at 7 days of age and a subclinical infection at 15 days of age. In piglets aged 3 days or less, the entire intestine was extensively infected with Cryptosporidium and the mucosa was severely damaged. In piglets 7 days of age or older, the upper small intestine was sparsely infected with the organisms, but the ileum and the large bowel were heavily infected with associated mucosal damage.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D003044:Coccidia / Q000648:ultrastructure; D003048:Coccidiosis / Q000469:parasitology / Q000662:veterinary*; D003092:Colitis / Q000469:parasitology / Q000662:veterinary*; D004198:Disease Susceptibility; D005856:Germ-Free Life; D007413:Intestinal Mucosa / Q000469:parasitology / Q000473:pathology; D007422:Intestines / Q000469:parasitology*; D013552:Swine; D013553:Swine Diseases / Q000469:parasitology*; D001616:beta-Galactosidase / Q000378:metabolism
D001616:beta-Galactosidase