Effect of butyrate on adenovirus infection in semipermissive cells.
Adenovirus 2 stimulated cellular DNA synthesis in quiescent cultures of semipermissive tsAF8 cells and 3T3 cells. Such stimulation was inhibited by Na-butyrate, which also inhibited viral DNA replication in tsAF8 cells. In addition, butyrate inhibited the expression of early regions E1A and E2 of adenovirus 2 in both tsAF8 and 3T3 cells, while it had little effect on permissive HeLa cells.
D000260:Adenoviruses, Human / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D000818:Animals; D002087:Butyrates / Q000494:pharmacology*; D002460:Cell Line; D006224:Cricetinae; D004247:DNA / Q000096:biosynthesis*; D004279:DNA, Viral / Q000096:biosynthesis; D005814:Genes, Viral; D006367:HeLa Cells; D006801:Humans; D007399:Interphase; D051379:Mice; D012367:RNA, Viral / Q000096:biosynthesis; D013696:Temperature
D002087:Butyrates; D004279:DNA, Viral; D012367:RNA, Viral; D004247:DNA