Nonsteroidal antiinflammatory agents. 2. [(Heteroarylamino)phenyl]alkanoic acids.
A series of [(heteroarylamino)phenyl]alkanoic acids having pyridine, quinoline, or pyrimidine as the heteroaryl moiety was prepared as potential antiinflammatory agents. Among them, 2-[4-(2-pyridylamino)phenyl]propionic acid (14b) showed excellent antiinflammatory and analgesic activities with less tendency to cause gastric side effects. Structure-activity relationships are discussed.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D001169:Arthritis, Experimental / Q000188:drug therapy; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000627:therapeutic use; D002351:Carrageenan; D004487:Edema / Q000188:drug therapy; D005260:Female; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000188:drug therapy; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D002264:Carboxylic Acids; D006571:Heterocyclic Compounds; D002351:Carrageenan