Discovery, isolation and structure of novel cephamycins of Streptomyces chartreusis.
By the use of HPLC technique after treatment with beta-lactamases, two novel cephamycins, SF-1623 and SF-1623B, were discovered and isolated from the fermentation broth of Streptomyces chartreusis SF-1623. The structures of SF-1623 and SF-1623B were determined to contain 3-sulfothiomethyl and 3-hydroxymethyl groups respectively, by chemical and enzymatic transformation reactions. Studies on the fermentation condition and process for the large scale preparation of antibiotic SF-1623 are also described.
D001419:Bacteria / Q000187:drug effects; D002511:Cephalosporins / Q000302:isolation & purification*; D002513:Cephamycins / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D013302:Streptomyces / Q000378:metabolism*
D002511:Cephalosporins; D002513:Cephamycins; C037483:SF 1623; C037484:SF 1623B