The enzymatic status of circulating lymphocytes as an index of the regenerative process in the lungs under stimulation with pyrimidine and purine derivatives. A clinical experimental study.
Enzyme activities in the circulating lymphocytes permit to judge the character of the regenerative process in the lung, and the severity of the patient's condition; it helps in estimating the prognosis and in evaluating the efficacy of the applied therapy. Potassium orotate and Riboxin intensify the regenerative process in the lung undergoing a compensatory-hypertrophic rearrangement, and enhance the functional activity of circulating lymphocytes as participants of the regenerative process and stimulate the oxidation-reduction processes in lymphocytes.
D000135:Acid Phosphatase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D005993:Glycerolphosphate Dehydrogenase / Q000097:blood; D006801:Humans; D006984:Hypertrophy / Q000201:enzymology; D007249:Inflammation / Q000188:drug therapy; D007290:Inosine Diphosphate / Q000494:pharmacology / Q000627:therapeutic use; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008168:Lung / Q000473:pathology / Q000502:physiology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000201:enzymology*; D008297:Male; D009504:Neutrophils / Q000201:enzymology; D009963:Orotic Acid / Q000494:pharmacology / Q000627:therapeutic use; D011687:Purines / Q000494:pharmacology* / Q000627:therapeutic use; D011743:Pyrimidines / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D012038:Regeneration / Q000187:drug effects*; D013385:Succinate Dehydrogenase / Q000097:blood; D014498:Uracil / Q000031:analogs & derivatives / Q000627:therapeutic use
D011687:Purines; D011743:Pyrimidines; D014498:Uracil; C002596:1-methyluracil; D009963:Orotic Acid; D007290:Inosine Diphosphate; D005993:Glycerolphosphate Dehydrogenase; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase