Indomethacin-induced hyperkalemia and renal failure in multiple myeloma.
3 patients with multiple myeloma developed hyperkalemic hypoaldosteronism and renal insufficiency while receiving indomethacin for bone pain. Claims are made that indomethacin has been responsible for these complications, possibly by inhibiting prostaglandin biosynthesis. Careful observation of myeloma patients during administration of this agent and perhaps other prostaglandin inhibitors appears warranted.
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000150:complications; D000368:Aged; D005260:Female; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced* / Q000150:complications; D007213:Indomethacin / Q000009:adverse effects* / Q000627:therapeutic use; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy; D011448:Prostaglandin Antagonists / Q000009:adverse effects / Q000627:therapeutic use
D011448:Prostaglandin Antagonists; D007213:Indomethacin