Disposition kinetics of metronidazole in children.
The pharmacokinetics of metronidazole was studied in 20 paediatric patients aged 6 weeks and 4 to 14 years, who had trichomonal vaginitis or an anaerobic bacterial infection. The dosage of metronidazole was about 10 or 20 mg/kg b.i.d. orally. The serum concentrations found in children and the corresponding calculated kinetic parameters were similar to those in adults after intake of an equal, weight-related dose. Metronidazole shows rapid diffusion into the saliva with a concentration ratio of about 1.0. This can provide the basis for an efficient non-invasive method of drug monitoring.
D000293:Adolescent; D000375:Aging; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007223:Infant; D007700:Kinetics; D008795:Metronidazole / Q000378:metabolism* / Q000627:therapeutic use; D011048:Polarography; D012463:Saliva / Q000032:analysis; D014848:Vulvovaginitis / Q000188:drug therapy / Q000378:metabolism*
D008795:Metronidazole