title: Treatment of gonococcal urethritis in men with a rifampicin-erythromycin combination.
abstract: A group of men with uncomplicated gonococcal urethritis were treated with a single oral dose of rifampicin (900 mg) and erythromycin stearate (1 g). Neisseria gonorrhoeae was isolated from four of 108 men at the first follow-up examination, and from none of 68 who attended a second follow-up examination. It is concluded that this rifampicin-erythromycin combination may be useful for the therapy of gonorrhea. It may be of particular value in the treatment of infections due to penicillin-resistant N. gonorrhoeae, since in vitro studies showed that both rifampicin and erythromycin were active against 20 strains of beta-lactamase-producing N. gonorrhoeae. The effect of this rifampicin-erythromycin combination against associated infections with Chlamydia trachomatis was disappointing. This organism was isolated from five of nine patients who had yielded isolates of C. trachomatis before treatment.
mesh_terms: D000284:Administration, Oral; D004359:Drug Therapy, Combination; D004917:Erythromycin / Q000008:administration & dosage*; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D012293:Rifampin / Q000008:administration & dosage*; D014526:Urethritis / Q000188:drug therapy*
chemical_list: D004917:Erythromycin; D012293:Rifampin