The influence of selenium intake on chronic adriamycin toxicity and lipid peroxidation in rats.
This paper reports on the influence of selenium intake on antioxidant protective systems during chronic adriamycin (AM) treatment in rats. Rats were kept for 14 weeks on a selenium deficient (Se-) diet or a diet containing selenium (Se+). No significant differences were found in any group with regard to the cardiac content of total and reduced glutathione (GSH) and heart superoxide dismutase specific activity. AM treatment did not modify lipid peroxidation as measured by cardiac malondialdehyde (MDH) formation in rats receiving either the Se- or the Se+ diet. In the Se+ rats AM had no effect on the exhalation of ethane or pentane but decreased the exhalation of ethane and increased that of pentane in the SE- rats. In Se- AM-treated rats mortality was higher. Since this did not seem to be correlated with modifications of any of the biochemical parameters taken into consideration, it is suggested that the better resistance of Se+ animals to AM treatment is related to some factors not yet identified.
D000818:Animals; D001944:Breath Tests; D004317:Doxorubicin / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000096:biosynthesis; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D012643:Selenium / Q000172:deficiency / Q000494:pharmacology*
D008054:Lipid Peroxides; D008315:Malondialdehyde; D004317:Doxorubicin; D005978:Glutathione; D012643:Selenium