Infectious vaccinia virus recombinants that express hepatitis B virus surface antigen.
Potential live vaccines against hepatitis B virus have been produced. The coding sequence for hepatitis B virus surface antigen (HBsAg) has been inserted into the vaccinia virus genome under control of vaccinia virus early promoters. Cells infected with these vaccinia virus recombinants synthesize and excrete HBsAg and vaccinated rabbits rapidly produce antibodies to HBsAg.
D000818:Animals; D000917:Antibody Formation; D002874:Chromosome Mapping; D004274:DNA, Recombinant; D005786:Gene Expression Regulation; D005796:Genes; D005814:Genes, Viral; D006514:Hepatitis B Surface Antigens / Q000235:genetics*; D006515:Hepatitis B virus / Q000276:immunology*; D008970:Molecular Weight; D011817:Rabbits; D014611:Vaccination; D014616:Vaccinia virus / Q000235:genetics* / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
D004274:DNA, Recombinant; D006514:Hepatitis B Surface Antigens; D014765:Viral Vaccines