Rats highly susceptible to experimental autoimmune encephalomyelitis obtained by crossing rats from strains with low susceptibility.
By crossing and back-crossing three strains of rats, Brown-Norway, Fischer, and PVG, none of which is definitely susceptible to experimental autoimmune encephalomyelitis (EAE), it is possible to obtain fully susceptible animals. Genetic analysis indicates the presence of Ir-genes in at least two of the strains (Fisher and PVG) related to the AgB complex, and genes of 'resistance' located on another chromosome. The latter appear to be different in the three strains; also the BN strain, which perhaps does not carry an IR-EAE gene, apparently carries effective genes of resistance.
D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics*; D005802:Genes, MHC Class II; D006579:Heterozygote; D008285:Major Histocompatibility Complex; D051381:Rats; D011919:Rats, Inbred Strains / Q000502:physiology*