Amoxapine intoxication in an infant: seizures arrested with diazepam.
A 15-month-old infant had hyperpyrexia and severe generalized seizures without cardiovascular toxicity after the ingestion of 250 mg of amoxapine, a new tricyclic antidepressant of the dibenzoxapine subclass. The seizures failed to respond to physostigmine or the usual anticonvulsant therapies, but were controlled after eight hours by a second administration of diazepam. The child died 144 hours after amoxapine ingestion.
D000061:Accidents, Home; D000657:Amoxapine / Q000506:poisoning*; D003975:Diazepam / Q000627:therapeutic use*; D003989:Dibenzoxazepines / Q000506:poisoning*; D006801:Humans; D007223:Infant; D008297:Male; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy* / Q000401:mortality
D003989:Dibenzoxazepines; D003975:Diazepam; D000657:Amoxapine