Active and passive mouse-protecting capacity of Pseudomonas aeruginosa protein vaccines.
Six different vaccines were prepared, each containing the soluble, practically lipopolysaccharide-free protein extract of 2 or 3 Pseudomonas aeruginosa strains. In active mouse protection tests the vaccines were shown to give protection against both homologous and heterologous serotype strains, and against strain PA-103 producing exotoxin A. In rabbits the vaccines were found to stimulate the production of protective antibodies demonstrable in a passive mouse protection test. The immune serum had a protective effect against the exotoxin A-producing strain PA-103, too. Toxicity of the vaccines was studied in mice (mouse weight gain test) and in rabbits (intracutaneous skin test and pyrogenicity). The vaccines were not or only slightly toxic.
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001428:Bacterial Vaccines / Q000276:immunology*; D005334:Fever / Q000209:etiology; D007116:Immunization, Passive; D007928:Lethal Dose 50; D051379:Mice; D011552:Pseudomonas Infections / Q000517:prevention & control*; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D011817:Rabbits; D012882:Skin Tests
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines