Effect of methylglucamine orotate on intracranial self-stimulation.
The effect of the memory improving substance methylglucamine orotate (MGO) on intracranial self-stimulation was investigated in rats. Self-stimulation (0.2 mn square pulses; 100 Hz frequency; 400 mn chain; 100-300 micro A current) was performed using electrodes in the lateral hypothalamus. MGO was administered intraperitoneally in doses of 112.5 mg/kg and 225 mg/kg or intraventricularly in a dose of 225 micrograms per rat. In chronic experiments, daily intraperitoneal injections of 225 mg/kg MGO were given during 10 days. The results show that intracranial self-stimulation is scarcely influenced by a single injection of retention improving MGO doses, but increased significantly by repeated MGO application.
D000818:Animals; D007274:Injections, Intraperitoneal; D008134:Long-Term Care; D008297:Male; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D008568:Memory / Q000187:drug effects*; D009963:Orotic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012653:Self Stimulation / Q000187:drug effects*
C022100:methylglucamine orotate; D009963:Orotic Acid; D008536:Meglumine