Biochemical evidence for multiple Ia molecules.
Sequential immunoprecipitation and isoelectric focusing studies using anti-Ia monoclonal antibodies have shown multiple I-A and I-E Ia molecules. These studies suggest that the genes coding for Ia polypeptide chains A alpha, A beta, E beta and E alpha might have undergone further duplication and mutated. This would explain the diversity seen with Ia molecules in their ability to "present" numerous self and non-self antigens for generation of immune response.
D000818:Animals; D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D003429:Cross Reactions; D005802:Genes, MHC Class II; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D007518:Isoantibodies; D008285:Major Histocompatibility Complex; D051379:Mice
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D000949:Histocompatibility Antigens Class II; D007518:Isoantibodies