Serial cytogenetic study of a human glioma cell line.
Chromosome studies were performed on a human glioma cell line. Nineteen passages were studied, and a heterogeneous chromosome complement with variable modal numbers was found. The main range varied from tetraploidy to triploidy. The presence of identical markers (9p-, 11p+, an increase in the copies of chromosome No. 7) in different passages suggests a clonal evolution.
D001932:Brain Neoplasms / Q000235:genetics*; D002460:Cell Line; D002869:Chromosome Aberrations; D005910:Glioma / Q000235:genetics*; D006801:Humans