Protective activity of immune sera against extracellular slime from Pseudomonas aeruginosa on experimental infection in mice.
Slime-extracts from Pseudomonas aeruginosa strains induced in rabbit synthesis of antibodies which protected mice against lethal intraperitoneal challenge. The antislime sera produced the maximal protection when given simultaneously with challenge dose of bacteria or 3 to 24 h before inoculation of animals. Some antisera exhibited also marked activity in groups of mice passively immunized 48, 72 or even 96 h before challenge. No effect was observed when immune serum was administered after infection.
D000818:Animals; D005110:Extracellular Space / Q000502:physiology; D007114:Immunization; D008297:Male; D051379:Mice; D011552:Pseudomonas Infections / Q000517:prevention & control*; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D011817:Rabbits