Effect of sidestream tobacco smoke components on alpha/beta interferon production.
Mouse embryo fibroblast cell cultures were treated with chemicals that are major components of sidestream (passive) cigarette smoke. These components were 4-aminobiphenyl and aniline-HCl. The cultures produced severely reduced levels of alpha/beta interferon after challenge with polyriboinosinic-polyribocytidylic acid when compared to control cultures. Treatment of additional cell cultures with 2-methylquinoline, and intermediate-level component of sidestream tobacco smoke, or hydrazine-sulfate, a minor component of sidestream tobacco smoke but a major component of mainstream (active) tobacco smoke, also resulted in inhibition of interferon induction with polyriboinosinic acid-polyribocytidylic acid. Therefore, treatment of the cell cultures with chemicals that are carcinogenic was equally effective in inhibiting alpha/beta interferon induction without regard to the sidestream or mainstream smoke origin of the chemical.
D000611:Aminobiphenyl Compounds / Q000494:pharmacology; D000814:Aniline Compounds / Q000494:pharmacology; D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D002478:Cells, Cultured; D004622:Embryo, Mammalian; D006834:Hydrazines / Q000494:pharmacology; D007370:Interferon Type I / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051379:Mice; D008809:Mice, Inbred C3H; D010947:Plants, Toxic; D011070:Poly I-C / Q000494:pharmacology; D011798:Quinaldines / Q000494:pharmacology; D012906:Smoke; D014026:Nicotiana
D000611:Aminobiphenyl Compounds; D000814:Aniline Compounds; D002273:Carcinogens; D006834:Hydrazines; D007370:Interferon Type I; D011798:Quinaldines; D012906:Smoke; C006757:4-biphenylamine; C029424:hydrazine; C037073:2-methylquinoline; D011070:Poly I-C; C023650:aniline