Acute treatment with trimethyltin alters alcohol self-selection.
Male rats of the Long-Evans strain were divided into two equal groups of nine each and given either 7.0 mg/kg trimethyltin (TMT) or 0.9% saline by intragastric gavage. The pattern of self-selection of alcohol in concentrations of 3%--30% was examined in both groups at 21 and 150 days following the gavage. The TMT-treated rat consistently drank less alcohol than did the controls at every concentration of alcohol. This difference in alcohol intake was equally significant when the rats were tested in a food-contingent, schedule-induced polydipsia situation. Further, although the TMT-lesioned animal consumed fewer calories per day in the form of alcohol, their overall daily caloric intakes were slightly higher than those of the controls. These results are interpreted as a consequence of damage to structures of the forebrain and as part of a syndrome of behavioral and neurological pathology.
D000428:Alcohol Drinking; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002755:Choice Behavior / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects; D008297:Male; D009115:Muridae; D009474:Neurons / Q000187:drug effects; D012931:Social Environment; D013649:Taste / Q000187:drug effects; D014220:Trialkyltin Compounds / Q000494:pharmacology*; D014298:Trimethyltin Compounds / Q000494:pharmacology*
D014220:Trialkyltin Compounds; D014298:Trimethyltin Compounds