Pharmacological studies on carbapenem antibiotics. II. Isolation of a PS-5-inactivating factor from the rat kidney.
A factor responsible for the in vivo metabolism of PS-5 was isolated from the microsomal fraction of the rat kidney. This factor, which did not attack penicillins and cephalosporins, was enzymologically identified with particle-bound renal dipeptidase. Under the action of this factor, PS-5 was inactivated to give three products designated PS-5D I, PS-5D II and PS-5D III.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D004150:Dipeptidases / Q000302:isolation & purification* / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D008658:Inactivation, Metabolic; D007668:Kidney / Q000201:enzymology*; D051381:Rats; D013845:Thienamycins / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D013845:Thienamycins; C016883:PS 5; D004492:Edetic Acid; D004150:Dipeptidases