title: Dissociations between the behavioral effects of LSD and tolerance development during ontogeny in cats: a novel approach to the study of tolerance mechanisms.
abstract: The characteristic behavioral effects of d-lysergic acid diethylamide (LSD) in cats first appeared at approximately 25 days of age and increased rapidly in magnitude over the next 10 days. However, 25 day old kittens showed no tolerance to the repeated administration of the drug. While the behavioral response to the initial dose of LSD remained relatively constant between 35 and 112 days of age, the tolerance gradually became more pronounced throughout this time period, reaching an adult level of virtually complete tolerance at 112 days. These findings provide new insight into the nature of the relationship between the primary drug action and the development of tolerance, and suggest a new strategy for investigating the neural bases of tolerance, i.e., examining the neurochemical effects of repeated LSD administration in kittens during various stages of tolerance development.
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002415:Cats / Q000254:growth & development*; D004361:Drug Tolerance; D005260:Female; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D011247:Pregnancy
chemical_list: D008238:Lysergic Acid Diethylamide