Induction of interferon by streptococcus pyogenes extracellular products.
Lymphocyte-activating streptococcal exoproteins, which were previously characterized, have been tested for their capacity to induce interferon in vitro. Two out of the 3 different streptococcal fractions, studied on mice splenocytes, were shown to elicit the production of a significant amount of interferon. A large proportion of the interferon detected in the supernatants from mice activated spleen cells was acid-labile interferon. The highest level of interferon titer was obtained with the streptococcal fraction identified as the erythrogenic toxin.
D000818:Animals; D001426:Bacterial Proteins; D005591:Chemical Fractionation; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology*; D007371:Interferon-gamma / Q000096:biosynthesis; D008213:Lymphocyte Activation; D051379:Mice; D008808:Mice, Inbred CBA; D008934:Mitogens / Q000494:pharmacology*; D011494:Protein Kinases / Q000378:metabolism; D013154:Spleen / Q000166:cytology
D001426:Bacterial Proteins; D007369:Interferon Inducers; D008934:Mitogens; C034866:streptococcal group A mitogen; D007371:Interferon-gamma; D011494:Protein Kinases