[Determination of plasma catecholamine. Effects of glucagon administration].
Basal plasma dopamine (DA), Norépinephrine (NE) and Epinephrine (E) were determined in controls (n = 15) essential hypertension (n = 19) and Pheochromocytoma (n = 9). Plasma NE was significantly higher in essential hypertension than in control and in 5 cases, plasma NE or E was 3 SD above mean control values. In 8/9 pheochromocytomas DA, E or NE were significantly elevated. In 1 case, catecholamine levels were within normal range during normotensive period. When a provocative glucagon test (1 mg I.V) was performed in controls, there was no change in blood pressure DA and NE levels, but a significant increase in plasma E 2.5 and 5 min. after injection. Similar results were obtained in 8/10 cases of labile hypertension. However in 2 cases plasma NE or E increased significantly without elevation in blood pressure. In 3/4 pheochromocytomas under normotensive phase, blood pressure and plasma catecholamines increased significantly; however in 1 case, no change was observed.
D000310:Adrenal Gland Neoplasms / Q000503:physiopathology*; D000328:Adult; D002395:Catecholamines / Q000097:blood*; D004298:Dopamine / Q000097:blood; D004837:Epinephrine / Q000097:blood; D005934:Glucagon; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D009638:Norepinephrine / Q000097:blood; D010673:Pheochromocytoma / Q000503:physiopathology*
D002395:Catecholamines; D005934:Glucagon; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine
Dosage des catécholamines plasmatiques. Effets de l'administration de glucagon.