Survival of MM red cells during hypothermia in two patients with anti-M.
The in vivo survival of M(M+N-) red cells in two patients with anti-M was studied during hypothermia. The antibodies were IgM, of low titer, and did not react at 30 degrees C. 51Cr survival studies were performed using 2 ml of labeled blood. There was normal circulation of M(M+N-) cells at 37 degrees C and no accelerated loss of these cells at blood temperatures between 16 and 28 degrees C. One patient received 187 ml of MN (M+N +) red cells when the blood temperature was 25 degrees C without evidence of clinical transfusion reactions and without development of positive direct anti-human globulin test. Hypothermia did not adversely affect the immediate survival of M(M+N-) red cells transfused to patients with anti-M antibodies reactive in vitro below 30 degrees C.
D000368:Aged; D001788:Blood Grouping and Crossmatching; D001803:Blood Transfusion / Q000379:methods; D004905:Erythrocyte Aging; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D007518:Isoantibodies / Q000096:biosynthesis*; D008951:MNSs Blood-Group System / Q000276:immunology*; D008875:Middle Aged; D013696:Temperature
D007518:Isoantibodies; D008951:MNSs Blood-Group System