Cyclophosphamide pretreatment in tumor cryotherapy: a comparison with alternative drugs.
The method of Turk and Lagrange for modulating immune responses in favor of the cell-mediated effector arm by using single high doses of cyclophosphamide 3 days before antigen has previously been shown to cause decreased rates of local tumor recurrence when adapted as an adjunctive therapy to cryosurgery in a murine model. This series of experiments compares cyclophosphamide, azathioprine, and methotrexate against cryosurgery alone in the same therapeutic protocol. Only cyclophosphamide gave enhanced numbers of cures; azathioprine caused an increase in metastases arising concurrently with local tumor recrudescence.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001379:Azathioprine / Q000008:administration & dosage; D003452:Cryosurgery; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D008727:Methotrexate / Q000008:administration & dosage; D051379:Mice; D008805:Mice, Inbred A; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000601:surgery*
D000970:Antineoplastic Agents; D003520:Cyclophosphamide; D001379:Azathioprine; D008727:Methotrexate