Enhancement of lymphocyte activation by BW755C in vitro.
BW755C considerably enhances the increased DNA synthesis of lymphocytes responding to mitogen stimulation. This effect is evident at much lower concentrations of BW755C than are required to inhibit cyclooxygenase or lipoxygenase enzymes. This suggests that in vivo effects of BW755C may not solely depend upon modification of arachidonic acid metabolism.
D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects*; D011453:Prostaglandins / Q000494:pharmacology; D011720:Pyrazoles / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D011453:Prostaglandins; D011720:Pyrazoles; D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine