title: Genetic variation in the expression of ADH in Drosophila melanogaster.
abstract: Several chromosomes derived from natural populations have been identified that affect the expression of alcohol dehydrogenase (ADH). Second chromosomes, which also carry the structural gene Adh, show a great deal of polymorphism of genetic elements that determine how much enzyme protein accumulates. The level of enzyme was measured in third instar larvae, 6-to-8-day-old males and in larval fat bodies and alimentary canals. In general, activities in the different organs and stages are highly correlated with one another. One line was found, however, in which the ADH level in the fat body is more than twice the level one would expect on the basis of the activity in alimentary canal. We have also found evidence of third-chromosome elements that affect the level of ADH.
mesh_terms: D000367:Age Factors; D000429:Alcohol Oxidoreductases / Q000235:genetics*; D000818:Animals; D004331:Drosophila melanogaster / Q000201:enzymology / Q000235:genetics*; D005786:Gene Expression Regulation; D014644:Genetic Variation; D007527:Isoenzymes / Q000235:genetics; D007814:Larva; D014018:Tissue Distribution
chemical_list: D007527:Isoenzymes; D000429:Alcohol Oxidoreductases