title: Inheritance of immunoglobulin E: genetic model fitting.
abstract: Total serum immunoglobulin E (IgE) concentration was measured on 316 members of five pedigrees selected through breast cancer probands. Sex- and age-adjusted natural logarithm-transformed IgE level was not found to differ between individuals with breast cancer or with cancer of any site and other relatives. Likelihoods of the polygenic and of one-locus, two-allele major gene and mixed models were computed. The analysis provided evidence for the presence of a polygenic component in the determination of IgE; it did not show evidence of a major gene effect.
mesh_terms: D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics / Q000276:immunology; D005260:Female; D005799:Genes, Dominant; D005808:Genes, Recessive; D006801:Humans; D007073:Immunoglobulin E / Q000235:genetics*; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D011336:Probability
chemical_list: D007073:Immunoglobulin E