Evaluation of the degree of desialylation of serum alpha 1-acid glycoprotein and alpha 1-antitrypsin.
A method for evaluating the degree of desialylation of alpha 1-AGP and alpha 1-AT has been developed. It consists in their simultaneous determination by radial immunodiffusion (RID) and electroimmunodiffusion (EID). When a desialylation exists, an underestimation by EID relative to RID is found. (1) No significant desialylation of alpha 1-AGP and alpha 1-AT occurred in normal subjects. (2) No correlation between desialylation of alpha 1-AGP and alpha 1-AT and their amounts existed. (3) Desialylation was preferentially observed in patients with severe hepatic damage but also with inflammatory disorders.
D000328:Adult; D006801:Humans; D005779:Immunodiffusion; D008103:Liver Cirrhosis / Q000097:blood; D009961:Orosomucoid / Q000378:metabolism*; D012216:Rheumatic Diseases / Q000097:blood; D012794:Sialic Acids / Q000097:blood*; D000515:alpha 1-Antitrypsin / Q000378:metabolism*
D009961:Orosomucoid; D012794:Sialic Acids; D000515:alpha 1-Antitrypsin