Comparison of the effects of bicuculline and strychnine on brain stem auditory evoked potentials in the cat.
1 Experiments were performed to determine the effects of intravenously applied bicuculline and strychnine on the click-evoked brain stem auditory evoked potentials (BAEP) of cats. 2 The BAEP was not affected by bicuculline (0.5 mg/kg, i.v.) administration. Strychnine (0.2 mg/kg, i.v.) administration caused a significant increase in the amplitude of peak 4, which is thought to be produced by potentials in the superior olive, lateral lemniscus and inferior colliculus. 3 These results suggest that strychnine blocks glycinergic inhibitory inputs to these auditory structures.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D001933:Brain Stem / Q000187:drug effects*; D002415:Cats; D004594:Electrophysiology; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D008297:Male; D013331:Strychnine / Q000494:pharmacology*; D013997:Time Factors
D013331:Strychnine; D001640:Bicuculline