[Modelling the oscillatory electrical activity of mollusk neurons].
A model is suggested describing slow membrane potential oscillations in moluscan neurons. It is based on the assumptions that the depolarization phase of oscillations is induced by slow calcium current and the hyperpolarization phase--by potassium current activated by intracellular Ca ions. It is stated that three types of neuronal electrical activity are possible depending on the values of the model parameters: stable membrane hyperpolarization down to the resting potential (-49 divided by -53 mV); slow oscillations of the membrane potential in a range of -30 divided by -60 mV with the period of 12-17 s; stable membrane depolarization up to -40 divided by -30 mV, which may lead to a repetitive firing behaviour of these neurons. Calculated dependence of the amplitude of membrane potential oscillations upon extracellular concentration of Ca, K and Na ions is in quantitative agreement with experimental data obtained by Barker and Gainer [4].
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002463:Cell Membrane Permeability; D008564:Membrane Potentials; D008959:Models, Neurological; D008974:Mollusca / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010507:Periodicity; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013997:Time Factors
D012964:Sodium; D011188:Potassium; D002118:Calcium
Modelirovanie ostsilliatornoĭ élektricheskoĭ aktivnosti neĭronov molliuskov.