Isobaric bupivacaine and hyperbaric amethocaine for spinal analgesia. A clinical comparison.
A 15 mg dose of isobaric bupivacaine 0.5% solution for spinal analgesia was compared with a clinically indicated dose of hyperbaric amethocaine 1% solution (10-16 mg) in 123 patients undergoing orthopaedic, urological and general surgical procedures. The 63 patients who received bupivacaine had a more limited spread of analgesia, which lasted longer and was accompanied by less hypotension and fewer complications than those who received amethocaine.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000775:Anesthesia, Spinal; D001794:Blood Pressure / Q000187:drug effects; D002045:Bupivacaine / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D013046:Specific Gravity; D013748:Tetracaine / Q000008:administration & dosage* / Q000009:adverse effects
D013748:Tetracaine; D002045:Bupivacaine