[Effect of alpha-tocopherol on the activity of the liver glutathione antioxidative system and the activity of serum aminotransferase in rats during tetrachloromethane poisoning].
The activities of glutathione peroxidase, glutathione reductase in the liver as well as of glutamate-pyruvate, and glutamate-oxaloacetate transaminase in blood serum were studied in rats which were injected tetrachloromethane in a dose of 1.04 mmol per 100 g mass for seven days. Tetrachloromethane poisoning is accompanied by a considerable decrease in the glutathione peroxidase activity in the liver and an increase in the aminotransferase activity in the blood serum. Additional administration of 20 and 30 mg of L-tocopherol per 100 g of mass prevents a tetrachloromethane-induced decrease in the activity of glutathione peroxidase in the liver and somewhat normalizes the activity of glutamate-pyruvate and glutamate-oxaloacetate transaminase in the blood serum. Possible mechanisms of the alpha-tocoferol protective action are under discussion.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008297:Male; D008697:Methane / Q000031:analogs & derivatives*; D051381:Rats; D000637:Transaminases / Q000097:blood*; D014810:Vitamin E / Q000494:pharmacology*
D014810:Vitamin E; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D000637:Transaminases; D008697:Methane
Vliianie alpha-tokoferola na aktivnost' glutationovoĭ antioksidantnoĭ sistemy v pecheni i aminotransferaznye aktivnosti v syvorotke krovi krys pri otravlenii tetrakhlormetanom.