title: Basis for the hypoactivity that accompanies rapid weight gain in hamsters.
abstract: The pattern of hypoactivity that accompanies rapid weight gain following septal lesions in hamsters was characterized. Lesioned hamsters displayed reduced levels of running, shorter and slower running bouts, and longer pauses. We examined whether this hypoactivity was due to reassignment of metabolic fuels from supporting physical activity to anabolism, or due to reduced capacity of running to induce psychomotor arousal and mobilize metabolic fuels. Septal lesions were associated with increased rate of ponderal growth and higher titers of circulating growth hormone and insulin. No difference in concentrations of muscle and liver glycogen, percentage of body fat, or the capacity of muscle homogenates to oxidize substrates were identified. Lesioned hamsters ran as fast and as long as control animals on electrical-shock reinforced treadmill, but were unable to generate as much heat in response to injection (0.8 mg/kg) of norepinephrine. We concluded that hypoactivity that accompanies rapid weight gain in hamsters results either from a reduced capacity of running to induce psychomotor arousal and provide incentives that normally motivate that behavior, or from a failure of running to mobilize metabolic fuels at a rate necessary to sustain normal running speed and duration, and not from reduced availability of metabolic fuels or reduced muscle capacity to oxidize metabolic substrates.
mesh_terms: D000818:Animals; D001143:Arousal / Q000502:physiology; D001835:Body Weight / Q000187:drug effects; D006224:Cricetinae; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D008647:Mesocricetus; D009042:Motivation / Q000502:physiology; D009043:Motor Activity / Q000502:physiology*; D009132:Muscles / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology; D012688:Septum Pellucidum / Q000502:physiology
chemical_list: D009638:Norepinephrine