The role of the adrenal medulla in the antihypertensive action of bromocriptine in neurogenic hypertensive dogs.
The effects of bromocriptine, a dopaminergic agent, on blood pressure were compared in normal and adrenal demedullated acute neurogenic hypertensive anesthetized dogs. The antihypertensive effect of bromocriptine (0.3 mg/kg IV) observed in intact dogs was not found in the absence of adrenal medulla. Since, in previous studies, it was found that this antihypertensive effect of bromocriptine was due to a dopaminergic mechanism the present results suggest the existence in adrenal glands of inhibitory dopaminergic receptors involved in the release of catecholamines.
D000313:Adrenal Medulla / Q000502:physiology*; D000818:Animals; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects; D001971:Bromocriptine / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D013997:Time Factors
D000959:Antihypertensive Agents; D001971:Bromocriptine