title: [Pharmacology of a new drug form, fenasal granules].
abstract: Experiments on mice and rats were made to study a new medicinal form, fenasal granules given per os and to compare it with ground tablets and powder of fenasal as regards the intestinal content, absorption capacity, anthelminthic activity and toxicity. The intestinal content and absorption capacity of fenasal were medicinal form-dependent. The highest anthelminthic activity was exhibited by fenasal granules. Acute toxicity of powder, ground tablets and granules of fenasal administered to mice and rats per os remained the same.
mesh_terms: D000042:Absorption; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006925:Hymenolepiasis / Q000188:drug therapy; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D051379:Mice; D009534:Niclosamide / Q000008:administration & dosage* / Q000378:metabolism / Q000633:toxicity; D011208:Powders; D051381:Rats; D013607:Tablets
chemical_list: D011208:Powders; D013607:Tablets; D009534:Niclosamide
vernacular_title: K farmakologii novoĭ lekarstvennoĭ formy fenasala-granul.