Lack of arrhythmogenicity of isoflurane following administration of aminophylline in dogs.
Induction of halothane anesthesia after aminophylline administration may cause ventricular arrhythmias. Isoflurane may be as effective a bronchodilator as halothane. This study was designed to determine whether induction of isoflurane anesthesia after intravenous aminophylline is arrhythmogenic in dogs. One group of six dogs was anesthetized with 1.5% isoflurane in the absence of aminophylline. Three additional groups of six dogs were given intravenous aminophylline 10, 25, or 50 mg/kg, respectively, followed 3 min later by 1.5% isoflurane. No arrhythmias occurred after aminophylline and isoflurane at any time in any animal. In contrast to halothane, induction of isoflurane anesthesia after aminophylline is safe and does not cause cardiac arrhythmias.
D000628:Aminophylline / Q000633:toxicity*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004347:Drug Interactions; D006339:Heart Rate / Q000187:drug effects; D007530:Isoflurane / Q000633:toxicity*; D008738:Methyl Ethers / Q000633:toxicity*
D008738:Methyl Ethers; D000628:Aminophylline; D007530:Isoflurane