Hepatic lesions in patients on anabolic androgenic therapy.
The histopathological changes in the livers of 11 patients treated with alkylated and nonalkylated anabolic androgenic steroids are presented. The histological changes in the liver included: proliferation of the bile ducts with or without cystic dilatation (9/11), peliosis (8/11), atypical hyperplasia of liver cells (2/11), and tumors (3/11). The latter included one case of cholangiocarcinoma, one of hepatocellular carcinoma, and one of combined cholangiocellular and hepatocellular carcinoma. The pathological changes in the liver in this series suggest a possible relationship between anabolic androgenic steroids and bile duct proliferation and/or cholangiocarcinoma.
D000368:Aged; D045930:Anabolic Agents / Q000009:adverse effects*; D000741:Anemia, Aplastic / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy*; D008107:Liver Diseases / Q000473:pathology*; D008113:Liver Neoplasms / Q000139:chemically induced / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009277:Nandrolone / Q000009:adverse effects; D010110:Oxymetholone / Q000009:adverse effects; D013739:Testosterone / Q000009:adverse effects / Q000031:analogs & derivatives
D045930:Anabolic Agents; D013739:Testosterone; D009277:Nandrolone; C004648:testosterone enanthate; D010110:Oxymetholone