Neuroleptanalgesia in the rabbit.
The efficacy of the neuroleptanalgesic combinations of fentanyl-fluanisone with diazepam; and etorphine-methotrimeprazine, either alone, or with diazepam, was investigated in the rabbit. The effects of these drugs on some cardiovascular variables were studied in chronically catheterized rabbits. Fentanyl-fluanisone and diazepam produced good surgical anaesthesia. Although respiratory depression occurred, this had little effect on blood gas values. In contrast, etorphine-methotrimeprazine and diazepam produced severe respiratory depression with consequent hypercapnia and acidosis.
D000138:Acidosis / Q000139:chemically induced; D000818:Animals; D002090:Butyrophenones / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology*; D004338:Drug Combinations; D005048:Etorphine / Q000009:adverse effects / Q000494:pharmacology*; D005283:Fentanyl / Q000494:pharmacology*; D006935:Hypercapnia / Q000139:chemically induced; D008728:Methotrimeprazine / Q000009:adverse effects / Q000494:pharmacology*; D009019:Morphinans / Q000494:pharmacology*; D009458:Neuroleptanalgesia / Q000662:veterinary*; D011817:Rabbits; D012119:Respiration / Q000187:drug effects; D013997:Time Factors
D002090:Butyrophenones; D004338:Drug Combinations; D009019:Morphinans; C005014:fluanisone; D005048:Etorphine; D008728:Methotrimeprazine; D003975:Diazepam; D005283:Fentanyl