Cycloamylose complexation of adamantane derivatives.
Spectrophotometric and pH potentiometric studies indicate that cyclohexaamylose (alpha-cyclodextrin) and cycloheptaamylose (beta-cyclodextrin) form aqueous complexes with all adamantane derivatives examined to date. Thermodynamic complex formation constants are reported for the substrates 1-adamantaneamine (amantadine), 1-adamantaneammonium ion, 1-adamantanemethylamine, 1-adamantane-methylammonium ion, 1-adamantanecarboxylic acid, 1-adamantane-carboxylate ion, 1-adamantaneacetic acid and 1-adamantaneacetate ion. The existence of these complexes implies that cycloamylose might serve as a therapeutic sequestering agent for adamantane derivatives.
D000218:Adamantane / Q000031:analogs & derivatives*; D055598:Chemical Phenomena; D002621:Chemistry; D003505:Cyclodextrins; D003912:Dextrins; D013213:Starch; D013816:Thermodynamics; D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D003912:Dextrins; D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins; D013213:Starch; C031215:betadex; D000218:Adamantane; C032613:alpha-cyclodextrin