[Effect of metoclopramide following selective proximal vagotomy with pyloroplasty].
In the early postoperative period after selective proximal vagotomy, there is often a delayed emptying of solid food. We examined the contraction of the antrum by intraluminal manometry in duodenal-ulcer-patients prior to (n = 20), 14 days after (n = 20) and 1--2 years after SPV with pyloroplasty. The motility was tested before and after i.v. injection of 20 mg metoclopramide. Preoperatively metoclopramide effected a significant rise of contraction in the antrum. 14 days after operation the motility was significantly reduced (85,7%--90,7%). Metoclopramide stimulated again the intraluminal pressure waves. Compared with the preoperative effect the metoclopramide induced motility also was reduced by 89,9% 1--2 years after operation the antral motility with or without metoclopramide injection had returned to preoperative values.
D000328:Adult; D004381:Duodenal Ulcer / Q000601:surgery*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use*; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy; D011708:Pylorus / Q000601:surgery*; D014628:Vagotomy; D014629:Vagotomy, Proximal Gastric
D008787:Metoclopramide
Zur wirkung von Metoclopramid nach selektiver proximaler Vagotomie mit Pyloroplastik.