An inverse relationship between serum immunoglobulin-G and intellectual functioning.
Serum immunoglobulin levels for IgA, IgE, IgG, and IgM were measured in 13 institutionalized, profoundly mentally retarded individuals and for 20 retarded and 29 intellectually average noninstitutionalized individuals. A significant elevation in IgG was observed for the retarded groups as compared with the intellectually average group. There was a significant inverse relationship between IgG and level of intellectual functioning. The elevated IgG is suggestive of the findings with auto-immune diseases and warrants further investigation.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008607:Intellectual Disability / Q000276:immunology*; D007360:Intelligence; D008297:Male
D007074:Immunoglobulin G