The carcinogenic effect of intracolonic administration of 1,2-dimethylhydrazine dihydrochloride in mice.
1,2-Dimethylhydrazine dihydrochloride (1,2-DMH) was given to Swiss mice in 1 or 10 weekly intracolonic instillations of 60 and 40 micrograms/g body weight, respectively. In mice that received a single treatment, the tumor incidences in the lungs, blood vessels and subcutis were 34% (p less than 0.006), 8 and 25 in females and 2, 20 and 0% in males, respectively. In mice treated repeatedly with the carcinogen, the corresponding tumor incidences were 34% (p less than 0.006), 38% (p less than 0.000001) and 12% (p less than 0.03) in females and 34, 10 and 0% in males, respectively. In control mice the tumor incidences in lungs, blood vessels and subcutis were 15, 8 and 2% in females and 22, 5 and 2% in males, respectively. The induction of large intestinal cancer, which was the main objective of this investigation, however, failed to materialize.
D019813:1,2-Dimethylhydrazine; D000818:Animals; D002273:Carcinogens; D003106:Colon; D004127:Dimethylhydrazines / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D007414:Intestinal Neoplasms / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D008763:Methylhydrazines / Q000633:toxicity*; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009383:Neoplasms, Vascular Tissue / Q000139:chemically induced; D012878:Skin Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D019813:1,2-Dimethylhydrazine