title: Morphometric analysis of aging skeletal muscle following endurance training.
abstract: Aging of skeletal muscle in the hindleg of the mouse is accompanied by a progressive increase in the amount of the interstitial tissue and especially that of lipid cells and fibroblasts. Quantitative analysis indicates that there was a nonsignificant increase in the total number of muscle fibers per unit area, perhaps due to a splitting process. The proportion of high oxidative fibers was decreased to a nonsignificant degree, and the remaining high oxidative fibers underwent a significant compensatory hypertrophy. Concomitantly, the number of low oxidative fibers increased significantly. This study revealed that endurance training in young animals induced morphometric changes very similar to those noticed in intact aging animals (i.e., splitting phenomenon, hypertrophy of high oxidative fibers, and an increased proportion of low oxidative fibers). It also became apparent that the skeletal muscle of old animals lacks the capacity to respond to enforced training, except for a further increase in the proportion of low oxidative fibers. It appears that aging muscle is unable to adapt to changing environmental circumstances.
mesh_terms: D000375:Aging; D000818:Animals; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D009132:Muscles / Q000033:anatomy & histology*; D005082:Physical Exertion; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D013385:Succinate Dehydrogenase