[Inhibition of the renal excretion of PAH by probenecid homologs].
The authors studied the effects of probenecid and five of its homologues on the renal excretion of p-amino-hippuric acid (PAH). All the compounds under study inhibited the excretion of PAH. Probenecid and its homologues were injected 15 min before the administration of PAH. With all the substances tested, the inhibition of the excretion of PAH was most marked during the first 30 min of the diuresis experiment. The extent of efficiency increases within the homologous series up to the diethyl compound; after that, the inhibitory effect decreases with the increase in chain length. In the dosage range under study, the probenecid homologues show linear dose-response relationships. With due regard to toxicity and efficiency, the authors conclude from the results obtained that the diethyl compound is the most potent substance; probenecid itself is less efficient, being twice as toxic.
D000618:Aminohippuric Acids / Q000652:urine*; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004305:Dose-Response Relationship, Drug; D005260:Female; D007928:Lethal Dose 50; D011339:Probenecid / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D010130:p-Aminohippuric Acid / Q000652:urine*
D000618:Aminohippuric Acids; D011339:Probenecid; D010130:p-Aminohippuric Acid
Hemmung der renalen PAH-Ausscheidung durch Probenecid-Homologe.