Airway response to leukotriene D4 in rhesus monkeys.
We studied the effect of leukotriene D4(LTD4) given by aerosol challenge on asthmatic and normal monkeys. The response to LTD4 occurred within 2 min., was prolonged at higher concentrations, was reversed by epinephrine, and more closely resembled an antigen response than a histamine response. Since LTD4 concentrations of 30-100 micrograms/ml produced a response similar to 2-20 mg/ml of histamine, the LTD4 was 300-900 times as potent as histamine on a molar basis. Thus, LTD4, which appears to reproduce an antigen-induced response in rhesus monkeys, may be a mediator of allergic asthma in these animals.
D000402:Airway Obstruction / Q000175:diagnosis / Q000276:immunology*; D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D001200:Ascaris / Q000276:immunology; D001249:Asthma / Q000276:immunology; D004195:Disease Models, Animal; D008253:Macaca mulatta; D012129:Respiratory Function Tests; D013189:SRS-A / Q000008:administration & dosage / Q000502:physiology*
D000941:Antigens; D013189:SRS-A