Alleviation of acetylsalicylic acid-induced fetal toxicity by calcium.
Alleviation of aspirin-induced fetotoxicity by calcium was investigated in rats. ASA (500 mg/kg s.c.) decreased the plasma Ca level in pregnant rats and that in the feto-placenta units. 0.05 M CaCl2 given to dams as tap water on days 8 through 20 of gestation inhibited ASA-induced hypocalcemic effect in maternal plasma. Tap water of 0.002-0.05 M CaCl2, Ca(OH)2 and Ca-lactate on days 8 through 20 of gestation alleviated malformations elicited by the administration of ASA (500 mg/kg s.c.) on the 11th day of gestation resulting in a decrease in the fetotoxicity in rats.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D001241:Aspirin / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D002122:Calcium Chloride / Q000494:pharmacology*; D004336:Drug Antagonism; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006996:Hypocalcemia / Q000139:chemically induced*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D002122:Calcium Chloride; D001241:Aspirin; D002118:Calcium