Regression of line-10 hepatocarcinoma with synthetic quinonyl muramyl dipeptide in strain-2 guinea pigs.
Multiple intralesional injections of quinonylmuramyl dipeptide-66, a new synthetic immunoadjuvant, with a vehicle oil such as squalene or squalane resulted in the regression of line-10 hepatocarcinoma in strain-2 guinea pigs. This chemically synthesized adjuvant should be a useful immunotherapeutic agent for cancer.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy*; D013185:Squalene
D000970:Antineoplastic Agents; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C023846:quinonyl-MDP-66; D013185:Squalene