Band keratopathy in MRL/l and MRL/n mice.
To define ocular abnormalities in mice with autoimmune disease, we performed biomicroscopic examinations and examined ocular tissue in MRL/l, MRL/n, NZB, NZB/NZW, and Palmerston North mice. Results were compared with MRL/Mp--lpr/lpr, C57BL/6J--lpr/lpr, and normal control strains. Eighty-seven percent of MRL/l and MRL/n mice had typical band keratopathy; this was confirmed by histologic examination. Posterior uveitis was found in 35% of adult MRL/l mice. MRL substrains are potentially important models of ocular disease.
D000818:Animals; D001327:Autoimmune Diseases / Q000150:complications* / Q000473:pathology; D002118:Calcium / Q000097:blood; D003316:Corneal Diseases / Q000209:etiology* / Q000473:pathology; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics; D010281:Parathyroid Hormone / Q000097:blood
D010281:Parathyroid Hormone; D003404:Creatinine; D002118:Calcium