The lectin properties of gluten as the basis of the pathomechanism of gluten-sensitive enteropathy.
The pathogenesis of gluten-sensitive enteropathy is as yet unknown. According to one theory gluten may act as a lectin with toxic properties for the intestinal cells. We can now confirm this theory by laser nephelometric measurements and demonstrate the oligomannosyl specificity of this lectin-like protein gluten. Furthermore, we demonstrate the highly more intensive binding capacity of gluten for the glycoproteins of the immature crypt cells of the intestinal brush border compared to those from the mature villous zone. It is discussed that gluten-sensitive enteropathy is caused by a genetically determined defect-glycosylation of intestinal glycoproteins with the synthesis of more mannosylated glycoproteins.
D002446:Celiac Disease / Q000209:etiology* / Q000276:immunology; D005983:Glutens / Q000235:genetics* / Q000378:metabolism; D006023:Glycoproteins / Q000096:biosynthesis; D006801:Humans; D007422:Intestines / Q000648:ultrastructure; D037102:Lectins / Q000276:immunology*; D008871:Microvilli / Q000378:metabolism
D006023:Glycoproteins; D037102:Lectins; D005983:Glutens