Species-dependent variables in blood cerebrospinal fluid barrier for proteins.
Cerebrospinal fluid/plasma concentration quotients for immunoglobulin G (I) and albumin (A) were determined in guinea pigs. Age and sex-dependent influences on these quotients (I/A) were analyzed and compared with the values for human lumbar, cisternal and ventricular cerebrospinal fluid. The ratio I/A, which characterizes the molecular size-dependent selectivity of the blood cerebrospinal fluid barrier function for proteins, was found to be a constant in a single species, but showed marked interspecies differences.
D000375:Aging; D000818:Animals; D001812:Blood-Brain Barrier; D002556:Cerebrospinal Fluid Proteins / Q000502:physiology*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007120:Immunochemistry; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D012737:Sex Factors; D013045:Species Specificity
D002556:Cerebrospinal Fluid Proteins; D007074:Immunoglobulin G