Alkyldiazohydroxides are stable intermediates in the degradation of n-nitroso-(acetoxyalkyl)-alkylamines in rat serum.
The decomposition in rat serum of N-nitroso-(acetoxyalkyl)-alkylamines 14C-labelled in different positions, was monitored. The determination of radioactivity of individual fractions permitted the determination of the rate-limiting step in their degradation scheme. From the primary nitroso-acetoxy-compounds the alkyldiazohydroxide shows the highest stability. Furthermore, it was shown that the alpha-hydroxy compounds of the secondary nitrosamines seem to be more stable than the hydroxylated primary ones.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003979:Diazonium Compounds / Q000097:blood*; D006207:Half-Life; D009603:Nitroso Compounds / Q000097:blood*; D051381:Rats
D003979:Diazonium Compounds; D009603:Nitroso Compounds