Drug intoxication: influence of hemoperfusion on human plasma fibronectin.
Fibronectin is a glycoprotein belonging to the opsonic system and able to mediate phagocytosis by the reticuloendothelial system (RES). Severe intoxications are often followed by a diminished capacity of RES-clearance. Patients with severe drug intoxications have lower concentrations of fibronectin in plasma than healthy persons. Charcoal hemoperfusion lowers plasma fibronectin by an average of 4.7 mg/dl. Initial values below 15 mg/dl did not undergo a significant decrease in the case of hemoperfusion. Regarding these findings, determination of plasma fibronectin seems a useful parameter for monitoring RES function during treatment of drug-intoxicated patients by hemoperfusion.
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006464:Hemoperfusion; D006801:Humans; D008297:Male; D008875:Middle Aged; D009391:Nephelometry and Turbidimetry; D010269:Paraquat / Q000506:poisoning; D011041:Poisoning / Q000097:blood* / Q000601:surgery; D018805:Sepsis / Q000097:blood; D012769:Shock / Q000097:blood
D005353:Fibronectins; D010269:Paraquat