Salted fish and inhalants as risk factors for nasopharyngeal carcinoma in Malaysian Chinese.
We conducted a case-control study of nasopharyngeal carcinoma among Malaysian Chinese to test inhalants, salted fish consumption, and use of tobacco, alcohol, and nasal ointments as risk factors for the disease. Interviews with 100 cases and 100 controls indicated that salted fish consumption during childhood was a significant risk factor (relative risk, 3.0; p = 0.04); childhood daily consumption of this food item compared to nonconsumption carried a relative risk of 17.4 [95% confidence interval = (2.7, 111.1)]. Occupational exposure to smokes (relative risk, 6.0; p = 0.006) and to dusts (relative risk, 4.0; p less than 0.001) was also significantly associated with nasopharyngeal carcinoma. The two risk factors (consumption of salted fish and exposure to smoke and/or dust) were independent of each other. There was no association between nasopharyngeal carcinoma and tobacco, alcohol, or nasal ointments.
D000281:Administration, Intranasal / Q000009:adverse effects; D000328:Adult; D000428:Alcohol Drinking; D002294:Carcinoma, Squamous Cell / Q000209:etiology; D002681:China / Q000208:ethnology; D005247:Feeding Behavior; D005260:Female; D005396:Fish Products / Q000009:adverse effects*; D006801:Humans; D008296:Malaysia; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000209:etiology*; D012306:Risk; D012907:Smoking