The effect of working environment contaminated with organic solvents on the activity of acid phosphatase in lymphocytes.
In 108 workers occupationally exposed to organic solvents containing benzene, toluene and xylene, the activity of acid phosphatase (AP) was determined in the peripheral blood lymphocytes. A positive correlation was found between the number of lymphocytes exhibiting redistribution of AP from lysosomes into the cytoplasm and the exposure time to the solvents. The cytochemical estimation of the lymphocyte AP activity might practically be used as a screening test for the early detection of the toxic effects of exposure to the above solvents.
D000135:Acid Phosphatase / Q000097:blood*; D000328:Adult; D000368:Aged; D000393:Air Pollutants / Q000009:adverse effects*; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D001554:Benzene / Q000009:adverse effects; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D012997:Solvents / Q000009:adverse effects*; D014050:Toluene / Q000009:adverse effects; D014992:Xylenes / Q000009:adverse effects
D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D012997:Solvents; D014992:Xylenes; D014050:Toluene; D000135:Acid Phosphatase; D001554:Benzene