In vitro absorption of [14C]leucine during inflammation and the effect of antiinflammatory drugs in the jejunum of rats.
1. Inflammation was induced in the hindlegs of rats by formalin injection and the in vitro absorption of [14C]leucine was studied. 2. Treatment of rats with formalin caused a reduction in the in vitro absorption of leucine from the mucosa of jejunum. 3. Oral administration of oxyphenbutazone or a herbal anti-inflammatory drug (Withania somnifera) prior to formalin injection resulted in no alteration in the jejunal absorption of [14C]leucine.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D007249:Inflammation / Q000378:metabolism*; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000378:metabolism; D007930:Leucine / Q000378:metabolism*; D008297:Male; D010113:Oxyphenbutazone / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D007930:Leucine; D010113:Oxyphenbutazone