title: Influence of amino acid deficiency and tRNA aminoacylation on DNA synthesis and DNA polymerase activity during the secondary immune response in vitro.
abstract: DNA synthesis and DNA polymerase activity are increased when KLH-primed guinea-pig lymphocytes are restimulated in vitro with the homologous antigen. This response can be modulated by glutamine deficiency and by an inhibitor of the histidyl-tRNA synthetase.
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D000941:Antigens / Q000276:immunology; D004247:DNA / Q000096:biosynthesis*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D005973:Glutamine / Q000378:metabolism; D006168:Guinea Pigs; D006433:Hemocyanins; D006641:Histidinol / Q000494:pharmacology; D007156:Immunologic Memory; D007700:Kinetics; D008198:Lymph Nodes / Q000166:cytology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism*; D012343:RNA, Transfer / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D000941:Antigens; D005973:Glutamine; D006641:Histidinol; D004247:DNA; D006433:Hemocyanins; D012343:RNA, Transfer; D004259:DNA-Directed DNA Polymerase; C032808:keyhole-limpet hemocyanin