Colorectal carcinomas have a characteristic ganglioside pattern.
The gangliosides in six colorectal and two pancreatic carcinomas were examined. Their concentration in the primary tumour and the metastases was 5-10 fold higher than in normal colon mucosa. This increase involved the simple gangliosides, GM3 and GD3, as well as complex mono- and disialogangliosides. Some complex monosialogangliosides were detected in all the colorectal and pancreatic carcinomas but neither in normal colon mucosa and pancreas nor in kidney and lung carcinomas.
D000368:Aged; D003106:Colon; D003110:Colonic Neoplasms / Q000032:analysis*; D005260:Female; D005679:G(M3) Ganglioside / Q000032:analysis; D005732:Gangliosides / Q000032:analysis*; D006801:Humans; D007413:Intestinal Mucosa / Q000032:analysis; D007680:Kidney Neoplasms / Q000032:analysis; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000032:analysis*; D012004:Rectal Neoplasms / Q000032:analysis*
D005679:G(M3) Ganglioside; D005732:Gangliosides; C026226:ganglioside, GD3