[Antineoplastic and curative antileukemic activity of 1,4-benzoquinone guanylhydrazone thiosemicarbazone and its hydrochloride on in vivo murine models].
By means of four murine models, the authors demonstrated in vivo that 1,4-benzoquinone guanylhydrazone thiosemicarbazone (1), which is known to be antimicrobially active, and its hydrochloride (2) exert an antineoplastic effect. In leukaemia P 388 and leukaemia L 1210 both compounds had a curative action already after four oral administrations. The "cured" animals were resistant or cross-resistant to further transmissions of leukaemia. The resistance was transmissible by splenocytes.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002279:Carcinoma 256, Walker / Q000188:drug therapy; D004351:Drug Resistance; D006146:Guanidines / Q000627:therapeutic use*; D007700:Kinetics; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008935:Mitoguazone / Q000031:analogs & derivatives / Q000627:therapeutic use*; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D051381:Rats
D000970:Antineoplastic Agents; D006146:Guanidines; C037931:1,4-benzoquinone guanylhydrazone thiosemicarbazone; D008935:Mitoguazone
Tumorhemmende und kurative antileukämische Wirksamkeit von 1,4-Benzochinonguanylhydrazonthiosemicarbazon und dessen Hydrochlorid an murinen Testmodellen in vivo.