Combined effect of ascorbic acid deficiency and underfeeding on the hepatic carnitine level in guinea-pigs.
Liver carnitine level decreased from 249 +/- 16.1 nmoles/g (mean +/- SEM) control value to 148 +/- 9.8 nmoles/g (59.4%) in ascorbic acid deficient guinea-pigs, while in the underfed ('pair-fed') group it decreased to 181 +/- 14.1 nmoles/g (72.6%). Underfeeding also resulted in lower ascorbic acid levels; the depression of carnitine in the underfed animals could be prevented by an overdose (200 mg daily) of ascorbic acid.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001206:Ascorbic Acid Deficiency / Q000378:metabolism*; D002331:Carnitine / Q000378:metabolism*; D005508:Food Deprivation; D006168:Guinea Pigs; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000378:metabolism
D001205:Ascorbic Acid; D002331:Carnitine