title: The antihypertensive effect of indapamide.
abstract: Fourteen patients with moderately severe essential hypertension were treated for 8 weeks with indapamide 2,5 mg/d. Systolic and diastolic blood pressures fell significantly from the 1st week of treatment; the rapid changes noted thereafter were described mathematically by decreasing power functions of time. Serum potassium and blood glucose values did not change significantly. Indapamide behaves as a power antihypertensive diuretic which appears safe at low doses and can be considered for the first-line treatment of essential hypertension.
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D004232:Diuretics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007190:Indapamide / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011674:Pulse / Q000187:drug effects; D013223:Statistics as Topic; D013997:Time Factors
chemical_list: D004232:Diuretics; D007190:Indapamide