Delayed-type hypersensitivity: probable role in the pathogenesis of dengue hemorrhagic fever/dengue shock syndrome.
The hypothesis presented proposes the involvement of a systemic form of a delayed-type hypersensitivity reaction in the pathogenesis of dengue hemorrhagic fever/dengue shock syndrome. It envisages the activation of sensitized T lymphocytes during a secondary infection by viral antigen present on the surfaces of mononuclear phagocytic cells. These antigen-activated T cells then release a variety of biologically active chemical mediators (lymphokines), which then produce the symptoms of shock and hemorrhage seen in cases of dengue hemorrhagic fever/dengue shock syndrome.
D002199:Capillary Permeability; D003715:Dengue / Q000097:blood / Q000150:complications / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D012769:Shock / Q000097:blood / Q000209:etiology / Q000503:physiopathology*