The effect of cyclophosphamide on autoimmune response to rats immunized with modified accessory glands.
It was found that the organ specific hemagglutinating autoantibodies to rat male accessory glands can be suppressed by the injection of a single dose of cyclophosphamide applied 3 days after the first immunization. On the other hand, injection of the drug 3 days before immunization did not modify the response, that is, there were comparable incidence and titers in both treated and the control animals. Cyclophosphamide did not appear to act on the homocytotropic antibodies. These results indicate that cyclophosphamide acts only when it is administered after antigenic stimulation, to suppress hemagglutinating antibodies production.
D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D001323:Autoantibodies / Q000096:biosynthesis* / Q000145:classification; D001324:Autoantigens / Q000008:administration & dosage*; D002030:Bulbourethral Glands / Q000276:immunology*; D003520:Cyclophosphamide / Q000494:pharmacology*; D005260:Female; D006386:Hemagglutination Tests; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D010323:Passive Cutaneous Anaphylaxis; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D000941:Antigens; D001323:Autoantibodies; D001324:Autoantigens; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide