Relationship of uterine closure to ovarian hormones and endocytosis in the rat.
Ovariectomized rats were treated with various hormonal regimens. The first stage of uterine closure and epithelial cell endocytosis were observed in ovariectomized rats treated with progesterone or progesterone after oestrogen priming but not in hormonally untreated rats or those treated with oestrogen alone. The simultaneous appearance of closure and endocytosis in response to the same physiological conditions is consistent with the proposal that the endocytotic activity in the uterine epithelial cells may remove fluid from the uterine lumen and thus mediate the first stage of uterine closure.
D000818:Animals; D002369:Castration; D004705:Endocytosis / Q000187:drug effects*; D004847:Epithelial Cells; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D014599:Uterus / Q000166:cytology / Q000187:drug effects / Q000502:physiology*
D011374:Progesterone; D004958:Estradiol