title: Distribution and retention in bone of 226Ra and comparison with the ICRP 20 model.
abstract: Analyses are presented of the ratios of 226Ra to calcium in over 650 samples of compact and cancellous bone from 66 female and 26 male subjects who had died from less than 1 to 60 yr after first exposure to radium. The 226Ra/Ca ratios were normalized to the terminal 226Ra skeletal content. The 226Ra/Ca ratios for vertebrae were essentially identical to those for other cancellous bone for a given subject. Comparisons of the data with predictions of the ICRP model of alkaline earth metabolism show that for female cancellous bone the normalized 226Ra/Ca ratios tended to be greater than predicted, while those for female cortical bone (femoral and tibial shaft) tended to be less. The data for males were fitted better by the model. A modification of the model to reduce the amount of radium deposited in soft tissue fitted the data better in some respects. A straight line linear least squares fit to the data appeared to fit as well as, or better than, the models. A radiation effect was suggested in that the normalized 226Ra/Ca ratio for vertebrae relative to the ratio expected increased with skeletal absorbed dose for vertebrae. However, no such effect was apparent for compact bone or for the cancellous bone as a whole.
mesh_terms: D001842:Bone and Bones / Q000032:analysis / Q000378:metabolism*; D002118:Calcium / Q000032:analysis / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008433:Mathematics; D008673:Metals, Alkaline Earth / Q000378:metabolism*; D008954:Models, Biological; D011379:Prognosis; D011883:Radium / Q000032:analysis / Q000378:metabolism*; D012727:Sex Characteristics; D014018:Tissue Distribution
chemical_list: D008673:Metals, Alkaline Earth; D002118:Calcium; D011883:Radium