Influence of type of dialyzer on the pharmacokinetics of amikacin.
The pharmacokinetics of amikacin was studied in 18 patients with terminal renal impairment (Clcr less than 5 ml/min during the course of 4-5 h hemodialysis sessions using four different kinds of dialyzer: RP 6, RP 514, Dialix, and Ultra Flo II. All patients received a single dose of 7.5 mg amikacin/kg body wt. at the beginning of the dialysis session. The type of dialyzers influences the serum half-life, the extraction coefficient, and the percentage of dose extracted during dialysis. A linear relationship was established between the percentage of the dose extracted by dialysis and the dialysis clearance of the antibiotic.
D000293:Adolescent; D000328:Adult; D000583:Amikacin / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D007612:Kanamycin / Q000031:analogs & derivatives*; D007676:Kidney Failure, Chronic / Q000378:metabolism; D007688:Kidneys, Artificial; D007700:Kinetics; D008297:Male; D008875:Middle Aged
D007612:Kanamycin; D000583:Amikacin