Transferable resistance to clindamycin, erythromycin, and tetracycline in Clostridium difficile.
Resistance to clindamycin, erythromycin, and streptogramins in Clostridium difficile could be transferred to a susceptible strain by mixed culture at low frequencies (1 x 10(-8) to 4 - 10(-8) per donor cell). Transfer of tetracycline resistance occurred at frequencies of 3 x 10(-7) to 5 x 10(-7). No plasmid DNA involved in these transfers could be detected.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology; D003013:Clostridium / Q000187:drug effects*; D003227:Conjugation, Genetic; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D002981:Clindamycin; D004917:Erythromycin; D013752:Tetracycline