Liver damage with reversible portal hypertension from vitamin A intoxication: demonstration of Ito cells.
A patient with sudden onset of ascites and hepatosplenomegaly made a complete recovery after vitamin A was withdrawn. Fluorescence microscopy on embedded tissue provided a simple method of demonstrating the accumulation of fat storage (Ito) cells in the liver.
D000328:Adult; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000139:chemically induced*; D006986:Hypervitaminosis A; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000473:pathology; D008856:Microscopy, Fluorescence