The effect of halothane anesthesia on platelet aggregation in vivo: decreased deposition on polytetrafluoroethylene arterial grafts in dogs.
The technique of gamma-imaging can be used to study the deposition of 111In-labeled platelets onto synthetic arterial grafts in vivo. Recent results suggested that platelet uptake on polytetrafluoroethylene (PTFE) grafts might depend on the choice of anesthetic. To evaluate the effect of anesthesia a series of experiments was performed in seven dogs wherein each animal served as its own control. The first of paired femoral or carotid PTFE grafts was inserted with the animal under pentobarbital anesthesia, and the graft was imaged for 90 minutes. A second graft was then inserted after at least 1 hour of halothane anesthesia. The mean activity ratio (describing platelet deposition) in the grafts inserted when only pentobarbital anesthesia was used was 7.04 +/- 0.55, compared to 1.20 +/- 0.07 in the grafts inserted with halothane anesthesia (P less than 0.01). Halothane anesthesia led to significantly decreased platelet uptake on canine PTFE arterial grafts. This effect was reversible, though not immediately, with no significant difference in graft activity noted by the day following surgery.
D000769:Anesthesia, Inhalation; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001807:Blood Vessel Prosthesis; D004285:Dogs; D005069:Evaluation Studies as Topic; D005263:Femoral Artery / Q000601:surgery; D006221:Halothane / Q000494:pharmacology*; D010634:Phenobarbital; D010974:Platelet Aggregation / Q000187:drug effects*; D011138:Polytetrafluoroethylene
D011138:Polytetrafluoroethylene; D006221:Halothane; D010634:Phenobarbital