Hemodynamic effects of intraaortic administration of protamine.
Seventy-nine consecutive patients were given protamine rapidly into the ascending aorta during neutralization of heparin at the end of cardiopulmonary bypass. Simultaneously left atrial, diastolic pulmonary arterial, or right atrial pressures were maintained constant by appropriate infusion of oxygenated blood into the aorta. The systemic and pulmonary vascular resistances did not change, mean arterial blood pressure increased slightly, and cardiac output increased significantly (p less than 0.001). It seems that this method of heparin neutralization is safe provided that the intravascular volume can be maintained constant.
D000328:Adult; D001013:Aorta, Thoracic; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002315:Cardiopulmonary Bypass; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006494:Heparin Antagonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011479:Protamines / Q000008:administration & dosage / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D006494:Heparin Antagonists; D011479:Protamines