title: Studies on the local immune response of the lactating ewe infected with Ostertagia circumcincta.
abstract: Changes in the flow and composition of gastric lymph were monitored in groups of lactating and non-lactating ewes which were repeatedly infected with Ostertagia circumcincta. As judged by faecal egg counts and worm burdens the lactating group was more susceptible than the non-lactating controls to the challenge infection. Increased amounts of pepsinogen as well as larger numbers of eosinophils and neutrophils entering the gastric lymph indicated considerable abomasal damage and inflammation in the lactating ewes. However, measurement of the flow of lymphocytes as well as the amount of IgA and IgA antibody in the lymph did not indicate that these aspects of the local immune response were impaired during lactation; in fact the output of IgA-containing lymphocytes as well as IgA itself was usually raised in the lactating sheep. Lymph flow was increased and lymph globulin concentrations proportionally decreased in lactating ewes, irrespectively of whether they were infected with worms. It is suggested that these changes were caused by the increase in voluntary food intake which occurs during lactation.
mesh_terms: D000818:Animals; D000906:Antibodies / Q000032:analysis; D005260:Female; D007070:Immunoglobulin A / Q000032:analysis; D007774:Lactation; D008196:Lymph / Q000032:analysis; D010029:Ostertagiasis / Q000276:immunology / Q000662:veterinary*; D011247:Pregnancy; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology*; D013270:Stomach; D014251:Trichostrongyloidea / Q000276:immunology*; D014252:Trichostrongyloidiasis / Q000662:veterinary*
chemical_list: D000906:Antibodies; D007070:Immunoglobulin A