title: Experimental Streptococcus equi infection in the horse: correlation with in vivo and in vitro immune responses.
abstract: Fourteen young outbred horses, divided into 2 groups on the basis of 18- or 24-hour skin-test reactions to Streptococcus equi, were inoculated nasopharyngeally with virulent S equi. Animals (n = 6, group I) with evidence of previous exposure to S equi (positive dermal response and existing serum antibodies), with one exception, developed minimal or no signs of disease after inoculation. In contrast, S equi skin-test negative and seronegative horses (n = 8, group II) developed predictable and severe clinical signs of infection after their inoculation, including shedding of the organism from nasal discharges and ruptured mandibular lymph nodes. Results of the present study indicate that resistance to virulent S equi infection is correlated with existing humoral and cellular immune responses to streptococcal antigens. In susceptible horses, recovery from infection was accompanied by the appearance of humoral antibodies and the acquisition of a positive skin-test response to S equi antigens.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D005260:Female; D006734:Horse Diseases / Q000276:immunology*; D006736:Horses; D007111:Immunity, Cellular; D007428:Intradermal Tests; D008297:Male; D012141:Respiratory Tract Infections / Q000276:immunology / Q000662:veterinary*; D013290:Streptococcal Infections / Q000276:immunology / Q000662:veterinary*
chemical_list: D000907:Antibodies, Bacterial