Altered P300 topography in schizophrenia.
The spatiotemporal evolution of the P300 waveform was topographically mapped in a group of ten male chronic schizophrenics, using the technique of brain electrical activity mapping. Group-average P300 waveforms were constructed for the schizophrenic group and a group of matched controls. The control group's P300 showed a concentric development about a maximum in the centroparietal area, slightly displaced toward the left. In contrast, the schizophrenic group's P300 maximum was more anterior and to the right, with a deficiency in left temporal activity. Using the technique of significance probability mapping, it was demonstrated that the maximum between-group difference was localized to the left-middle and posterior temporal regions, where the schizophrenic group was deficient in activity.
D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000295:instrumentation; D003201:Computers; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography / Q000295:instrumentation; D005071:Evoked Potentials; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000503:physiopathology*; D013702:Temporal Lobe / Q000503:physiopathology