Changes in ventricular fibrillation threshold induced by contrast agents during acute coronary artery occlusion.
In the first few hours after acute coronary thrombosis, clinical coronary angiography is associated with enhanced risk of ventricular fibrillation. In these experiments, the ventricular fibrillation threshold (VFT) was measured in anesthetized dogs before and during acute occlusion of the left circumflex coronary artery. Ischemia alone reduced the fibrillation threshold. Angiography with 1- or 2-ml does of Renografin 76 lowered VFT significantly more than did equal doses of iohexol or iopamidol. It is concluded that nonionic agents may be safer for coronary angiography in the presence of acute coronary insufficiency.
D000792:Angiography / Q000009:adverse effects; D000818:Animals; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D003973:Diatrizoate / Q000009:adverse effects; D003974:Diatrizoate Meglumine / Q000009:adverse effects; D004285:Dogs; D004338:Drug Combinations / Q000009:adverse effects; D005260:Female; D007472:Iohexol; D007479:Iopamidol; D007483:Iothalamic Acid / Q000009:adverse effects / Q000031:analogs & derivatives; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology*; D012306:Risk; D014283:Triiodobenzoic Acids / Q000009:adverse effects; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology*
D003287:Contrast Media; D004338:Drug Combinations; D014283:Triiodobenzoic Acids; D003973:Diatrizoate; D007483:Iothalamic Acid; D003974:Diatrizoate Meglumine; D007472:Iohexol; C027278:urovision; D007479:Iopamidol