title: The effects of using different grades of PVP and gelatin as binders in the fluidized bed granulation and tabletting of lactose.
abstract: The effects of using different grades of PVP and gelatin binders on three sieve fractions of lactose granulated in a fluidized bed granulator and tablets have been studied. Increasing the molecular mass of PVP or bloom number of gelatin resulted in a decrease in granule friability but in an increase in their average size and porosity and in the tensile strengths of the resulting tablets when compressed to a fixed apparent density. The results have been explained in terms of the effects of moist and dry binder bridges on bonding of particles in granules and tablets.
mesh_terms: D004339:Drug Compounding; D005079:Excipients; D005780:Gelatin; D007785:Lactose; D008970:Molecular Weight; D010316:Particle Size; D011205:Povidone; D011208:Powders; D013607:Tablets
chemical_list: D005079:Excipients; D011208:Powders; D013607:Tablets; D005780:Gelatin; D011205:Povidone; D007785:Lactose