Monosaccharide absorption and water secretion during disaccharide perfusion of the human jejunum.
During jejunal perfusion of normal subjects with isotonic mannitol-saline containing glucose, maltose or sucrose (112 mmol/l), monosaccharide absorption from disaccharides was greater than expected from the intraluminal concentration of free monosaccharides, and water secretion was greater than with glucose. With equimolar (112 mmol/l) glucose + disaccharide mixtures, intraluminal glucose concentrations were similar to but total glucose absorption less than expected from experiments with the individual sugars. The results favour sequential hydrolysis-absorption whereby high concentrations of monosaccharide accumulate at the brush border and promote sugar uptake by conventional rather than 'disaccharidase-related' transport, and stimulate water secretion by local osmotic effects.
D000293:Adolescent; D000328:Adult; D001692:Biological Transport; D004187:Disaccharides / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006868:Hydrolysis; D007408:Intestinal Absorption; D007583:Jejunum / Q000378:metabolism*; D008297:Male; D009005:Monosaccharides / Q000378:metabolism*; D010477:Perfusion; D014867:Water / Q000378:metabolism*
D004187:Disaccharides; D009005:Monosaccharides; D014867:Water; D005947:Glucose