[Effect of L-thyroxine on content of carbohydrate components of glycoproteins in subcellular fractions of liver, thyroid gland and blood cells of rats].
Content of carbohydrate components of glycoproteins (sialic acids, hexosamines, hexoses bound with proteins and L-fucose), their correlation and normalization in subcellular fractions of liver and thyroid gland tissues as well as in blood cells were studied after administration of various doses of L-thyroxin. Various doses of the hormone caused a dissimilar effect on alterations of the carbohydrate components in the structural elements of the tissues studied. Within 24 days after the hormone administration its small doses increased generally the carbohydrate content, middle doses--decreased their content in mitochondria and microsomes but increased in homogenate, plasmatic, mitochondrial and microsomal membranes, high doses--decreased the carbohydrate components in all the preparations studied. The period of normalization in the level of carbohydrate-containing components of glycoproteins from rat liver tissue depended on the dose of L-thyroxin administered. Quantitative impairments in carbohydrate-containing components of glycoproteins are discussed.
D000818:Animals; D002241:Carbohydrates / Q000032:analysis; D006023:Glycoproteins / Q000097:blood / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D013347:Subcellular Fractions / Q000378:metabolism; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism*; D013974:Thyroxine / Q000494:pharmacology*
D002241:Carbohydrates; D006023:Glycoproteins; D013974:Thyroxine
Vliianie L-tiroksina na soderzhanie uglevodnykh komponentov glikoproteidov v subkletochnykh fraktsiiakh pecheni, shchitovidnoĭ zhelezy i formennykh élementov krovi u krys.