The pharmacokinetics and availability of niflumic acid in humans.
The pharmacokinetic parameters and relative availability of niflumic acid in two different pharmaceutical preparations were studied in 12 subjects after a single oral administration. Total plasma clearance averaged 45 ml/min, and the half-life of elimination approximately 2 h, giving a distribution volume of 0.12 l/kg on the average. The values of these pharmacokinetic parameters were in agreement with the general characteristics of this type of substance, a weak acid strongly bound to plasma proteins. Comparison of the systemic availability of the two oral forms showed no difference; they were probably close to 100%.
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002214:Capsules; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D009539:Nicotinic Acids / Q000378:metabolism*; D009544:Niflumic Acid / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D013535:Suspensions
D002214:Capsules; D009539:Nicotinic Acids; D013535:Suspensions; D009544:Niflumic Acid