Ocular penetration of amikacin following intramuscular injection.
Amikacin sulfate was given intramuscularly (IM) (7.5 mg/kg) to study its ocular penetration in man. Seventy-three patients with cataracts received a single dose and 35 received two doses given 5 1/2 to 12 hours apart. After a single dose the aqueous humor levels of the antibiotic between two and ten hours ranged from 0.15 to 3.10 mg/L (average and median, 1.0 mg/L). Two doses given 5 1/2 to eight hours apart produced an average level of 3.5 mg/L (range, 0.91 to 8.31 mg/L). When the second dose was given nine to 12 hours after the first, the aqueous humor levels were similar to those found for a single dose. Aqueous humor concentrations of 1.0 mg/L of amikacin would be expected to be bactericidal for most gram-negative bacterial pathogens, whereas levels of 3.5 mg/L would inhibit most strains of Staphylococcus aureus and many strains of Pseudomonas aeruginosa.
D000328:Adult; D000368:Aged; D000583:Amikacin / Q000032:analysis / Q000494:pharmacology* / Q000627:therapeutic use; D001082:Aqueous Humor / Q000032:analysis; D001424:Bacterial Infections / Q000188:drug therapy; D005123:Eye / Q000187:drug effects*; D005128:Eye Diseases / Q000188:drug therapy; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007612:Kanamycin / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged
D007612:Kanamycin; D000583:Amikacin