Does neurotoxic conditioning accelerate nerve regeneration?
The prototype environmental neurotoxin, 2,5-hexanedione (2,5-HD), induces changes in somata of sensory ganglia that are morphologically similar to chromatolysis: this study assessed the functional significance of neuronal alterations. Experimental rats were exposed 6 weeks to 2,5-HD, and after 1 week without treatment were then subjected to experimental crush of the sciatic nerve (paired controls were unintoxicated). Nerve regeneration was assayed by the pinch test 4 to 13 days after crush. These preliminary results did not show an accelerated rate of axonal outgrowth; however, there was a small but significant (P less than 0.05) decrease in the initial delay.
D000818:Animals; D001369:Axons / Q000187:drug effects / Q000502:physiology; D003213:Conditioning, Psychological / Q000502:physiology*; D005260:Female; D006588:Hexanones / Q000494:pharmacology*; D007659:Ketones / Q000494:pharmacology*; D009409:Nerve Crush; D009410:Nerve Degeneration / Q000187:drug effects*; D009416:Nerve Regeneration; D051381:Rats; D011919:Rats, Inbred Strains; D012583:Schwann Cells / Q000187:drug effects / Q000502:physiology; D012584:Sciatic Nerve / Q000187:drug effects / Q000502:physiology*
D006588:Hexanones; D007659:Ketones; C011269:2,5-hexanedione