Pharmacokinetic relationships between cinromide and its metabolites in the rhesus monkey I: 3-Bromocinnamamide, an active metabolite.
Fifty percent of a cinromide dose was metabolized to an active metabolite in the rhesus monkey. The steady-state concentration of this metabolite was 3-6 times that of the parent drug, depending on the route of administration. Cinromide is a medium-extraction ratio drug with a short half-life (0.92 +/- 0.23 hr) when compared with the active metabolite, which has a low extraction ratio and a longer half-life (4.43 +/- 0.76 hr). Incomplete oral bioavailability of cinromide is a result of first-pass metabolism rather than incomplete absorption.
D000818:Animals; D001682:Biological Availability; D001711:Biotransformation; D002934:Cinnamates / Q000378:metabolism*; D006207:Half-Life; D007700:Kinetics; D008253:Macaca mulatta; D008297:Male; D013997:Time Factors
D002934:Cinnamates; C024302:3-bromocinnamamide; C018490:cinromide