[Relationship between androgen and estrogen receptors and clinico-morphological characteristics of prostatic cancer].
The paper presents the results of studies on cytoplasmic receptors of androgens (AR) and estrogens (ER) in tumors of 50 patients with prostate carcinoma with respect to age, histological structure and degree of tumor differentiation, and stage of the disease. The study showed the majority of tumors in patients not previously treated with estrogens to contain one or both types of receptors. In prostate carcinoma AR were found more frequently and both receptors were present twice as frequently in elderly as compared to senile patients. In the latter, adenocarcinomas containing only ER were predominant. AR could be detected more frequently in highly differentiated than in poorly differentiated tumors. ER did not correlate with the histological structure and degree of differentiation of the tumor. A negative correlation was observed between the stage of the tumor progression and the presence of AR in prostate carcinoma. AR and ER were seldom found in tumors of the patients treated with estrogens for a long time. Among 13 patients who died from advanced tumor, no AR were found in 12 tumors, both receptors were present in 1 tumor, and ER alone in 5 tumors.
D000230:Adenocarcinoma / Q000032:analysis* / Q000188:drug therapy / Q000473:pathology; D000368:Aged; D004967:Estrogens / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000032:analysis* / Q000188:drug therapy / Q000473:pathology; D011944:Receptors, Androgen / Q000032:analysis*; D011960:Receptors, Estrogen / Q000032:analysis*; D011987:Receptors, Steroid / Q000032:analysis*
D004967:Estrogens; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011987:Receptors, Steroid
Vzaimosviaz' mezhdu retseptorami androgenov, éstrogenov i kliniko-morfologicheskoĭ kharakteristikoĭ raka predstatel'noĭ zhelezy.