[Effect of the interferon inducer RFf2 on the course of an infection due to the rabies virus in mice].
The data of the study on the influence of an interferon inducer, phage RFf2 RNA, on the course of infection with fixed rabies virus and on the formation of postvaccination immunity are presented. The inoculation of the inducer in a dose of 1 mg/kg was shown to produce interferon in the blood of white mice within 6 hours up to 320 units/ml which decreased by 24 hours to 20-40 units/ml. No protective effect, however, was observed upon intracerebral inoculation of white mice with fixed rabies virus, CVS strain. An increased dose of the inducer resulted in the development of a marked protective effect (50%) particularly after peripheral inoculation of the virus when the latter was administered simultaneously with the inducer. The use of the inducer in combination with various types of rabies vaccines (tissue culture inactivated, sheep brain inactivated, Fermi type vaccines) exerted no influence on the resistance of the animals to subsequent inoculation with the virus or on the formation of postvaccination immunity. At the same time, inoculation of the inducer alone, two weeks before challenge, protected 30% of the animals as compared with 100% mortality in the control group. Further studies on the influence of interferon on the course of the infectious process in rabies and formation of postvaccination immunity are required.
D000818:Animals; D001435:Bacteriophages / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D007110:Immunity, Active; D007114:Immunization; D007369:Interferon Inducers / Q000276:immunology / Q000627:therapeutic use*; D051379:Mice; D012367:RNA, Viral / Q000276:immunology; D011818:Rabies / Q000276:immunology / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000276:immunology; D013997:Time Factors
D007369:Interferon Inducers; D012367:RNA, Viral; D011819:Rabies Vaccines
Vliianie induktora interferona RFf2 na techenie infektsii, vyzvannoĭ virusom beshenstva u mysheĭ.