Duration of immunity and absorption of cysticerci in calves after treatment of Taenia saginata cysticercosis with praziquantel.
Calves were first infected with 5000 Taenia saginata eggs at six to 10 weeks old and treated with praziquantel 12 weeks later. Complete immunity against challenge lasted for at least 12 weeks following anthelmintic treatment. Six months after drug treatment over 90 per cent of the cysticerci had been completely absorbed but some were still detectable especially in the heart. An increase was observed in the ELISA values of sera from infected calves following treatment with praziquantel, but no such rise was detected in sera from resistant calves after challenge infection.
D000367:Age Factors; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000276:immunology*; D003551:Cysticercosis / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*; D003552:Cysticercus / Q000187:drug effects; D004797:Enzyme-Linked Immunosorbent Assay; D007109:Immunity / Q000187:drug effects; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D011223:Praziquantel / Q000494:pharmacology* / Q000627:therapeutic use; D013621:Taenia / Q000187:drug effects; D013622:Taeniasis / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*
D007546:Isoquinolines; D011223:Praziquantel