title: Scintigraphic myocardial imaging with 99mTc-labelled gluconate of experimentally produced cardiomyopathy in dogs.
abstract: In 10 dogs experimental cardiomyopathy was produced using high intravenous doses of adrenaline and theophylline. The possibility of scintigraphic detection of this non-ischaemic damage was tested by means of 99mTc-gluconate. In 5 dogs the scintigraphic examination was carried out 4 hrs following the production of the damage. In all 5 cases a marked positivity of the heart scan was observed. The finding was confirmed by the radioactivity of tissue samples from all sections of the heart. In 3 out of 5 dogs the histological examination of the myocardium (PAS and HBFP staining) was positive. In the remaining 5 dogs the scan was performed 24 hrs following the development of the damage. A positive scintigraphic finding was observed in 4 cases, the degree of accumulation being lower than at 4 hrs. The radioactivities of tissue samples were also significantly lower as compared with the 4-hr values. In contrast, the histological findings were markedly positive in all 5 dogs. It follows that 99mTc-gluconate is capable of detecting in addition to infarctions non-ischaemic damages to the myocardium, too. The normalization of the finding is very quick. This experimental finding appears to be of importance in clinical practice.
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000378:metabolism; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004837:Epinephrine / Q000008:administration & dosage; D005942:Gluconates / Q000378:metabolism; D006321:Heart / Q000000981:diagnostic imaging*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D013667:Technetium / Q000378:metabolism; D013806:Theophylline / Q000008:administration & dosage; D013997:Time Factors
chemical_list: D005942:Gluconates; D015609:Organotechnetium Compounds; C032080:technetium Tc 99m gluconate; D013667:Technetium; D013806:Theophylline; D004837:Epinephrine