Serum inhibitory activity on granulocyte-macrophage colony formation.
Normal and chloroform-extracted human sera, fractionated by Sephadex column chromatography, have been tested for inhibitory activity on granulocyte-macrophage (GM) colony formation. It was found that this activity is connected with lipoproteins (inhibitors of granulocyte-macrophage colony stimulating factor) and low molecular weight substances (7000; 13,000) which can act as specific polypeptide chalones.
D000818:Animals; D001853:Bone Marrow / Q000276:immunology; D002478:Cells, Cultured; D002850:Chromatography, Gel; D003114:Colony-Forming Units Assay; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D007106:Immune Sera / Q000276:immunology* / Q000302:isolation & purification; D008264:Macrophages / Q000276:immunology*; D051379:Mice
D007106:Immune Sera