The effects of caerulein on exocrine pancreatic secretion in pigs.
Caerulein administered to anaesthetized pigs by slow i.v. infusions at doses of 0.5, 1.0 and 2.0 ng kg-1 min-1 for 30 min, stimulated pancreatic juice production, increased the protein content of the juice and enhanced its amylolytic, lipolytic and proteolytic activities. In a single experiment, an i.v. infusion of secretin (0.001 U kg-1 min-1) lasting through the whole experimental time, provoked potentiation of the caerulein stimulatory effects on pancreatic juice production, protein content and amylolytic activity.
D000818:Animals; D002108:Ceruletide / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010189:Pancreatic Juice / Q000032:analysis / Q000378:metabolism*; D012633:Secretin / Q000494:pharmacology / Q000502:physiology; D012756:Sheep / Q000378:metabolism; D013552:Swine / Q000378:metabolism*
D012633:Secretin; D002108:Ceruletide