Glass-ceramic-mediated, magnetic-field-induced localized hyperthermia: response of a murine mammary carcinoma.
Hyperthermia has been found to be a useful modality for cancer therapy. In this report, a biocompatible, ferrimagnetic glass-ceramic capable of inducing localized hyperthermia by hysteresis heating upon exposure to an alternating magnetic field is presented. When the glass-ceramic was placed in the region of a subcutaneously transplanted, weakly antigenic breast carcinoma and subjected to the magnetic field, sufficient temperature rise was obtained to cause significant (approximately 50%) tumor regrowth delay and a 12% permanent control. The data demonstrate that glass-ceramic-mediated hysteresis heating may be a useful therapeutic approach in the treatment of cancer which offers the advantage of producing a highly localized and predictable tumor volume hyperthermia.
D000818:Animals; D002455:Cell Division; D002516:Ceramics; D004574:Electromagnetic Fields; D005898:Glass; D006358:Hot Temperature / Q000627:therapeutic use*; D008325:Mammary Neoplasms, Experimental / Q000473:pathology / Q000628:therapy*; D008722:Methods; D051379:Mice; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains