title: Calcium and magnesium nutrition in human hypertension.
abstract: Many studies suggest that reduced consumption of calcium or magnesium is associated with an increased risk of developing hypertension and cardiovascular disease. Results of animal studies show that restriction of calcium increases, and supplementation with calcium lowers, the blood pressure of normal and hypertensive rats. Data from the Health and Nutrition Examination Survey I done by the National Center for Health Statistics document the relation between dietary calcium intake and the risk of hypertension in the United States. Hypertensive persons consumed 18% less dietary calcium (hypertensive, 572 +/- 17 mg, versus normotensive, 695 +/- 7 mg; p less than 0.0001). Of the 17 nutrients analyzed, only calcium distinguished hypertensive persons from normotensive persons in all subgroups. Of all nutritional factors assessed, reduced consumption of calcium most consistently distinguishes hypertensive persons from normotensive persons.
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001794:Blood Pressure; D002118:Calcium / Q000502:physiology; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002136:Calcium, Dietary; D004032:Diet; D005260:Female; D006801:Humans; D006973:Hypertension / Q000178:diet therapy / Q000188:drug therapy / Q000453:epidemiology*; D008274:Magnesium / Q000502:physiology; D008297:Male; D008875:Middle Aged; D051381:Rats
chemical_list: D002121:Calcium Channel Blockers; D002136:Calcium, Dietary; D008274:Magnesium; D002118:Calcium