title: Effect of nonsteroidal antiinflammatory drugs on human monocyte chemotaxis in vitro.
abstract: Human blood monocytes were incubated in vitro with ibuprofen, naproxen, and indomethacin at clinically relevant concentrations and were subsequently tested for chemotactic responsiveness in a modified Boyden chamber with zymosan-activated serum as the chemotactic agent. Ibuprofen and naproxen inhibited monocyte chemotaxis at concentrations above 25 micrograms/ml. The inhibition was dose dependent and a 50% inhibition (ID50) was seen at 70 and 62 micrograms/ml, respectively. Indomethacin inhibited monocyte chemotaxis at concentrations above 1 microgram/ml, but never reached ID50. It is concluded that the suppression of blood monocyte migration (ID50) is not a general property of all nonsteroidal antiinflammatory drugs.
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D009000:Monocytes / Q000276:immunology; D009288:Naproxen / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D009288:Naproxen; D007052:Ibuprofen; D007213:Indomethacin