Monoclonal IgA J539 binds galactopyranosyl antigens on its surface.
Murine monoclonal IgA J539 binds to methyl beta-D-galactopyranoside. With nearly the same affinity, it binds to methyl 6-O-pivaloyl-beta-D-galactopyranoside (4) and to methyl 6-O-beta-D-gentiobiosyl-beta-D-galactopyranoside (7). These observations confirm that the combining area of J539 is of the surface-, and not of the cavity-type.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000915:Antibody Affinity; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000276:immunology*; D001666:Binding Sites, Antibody; D055598:Chemical Phenomena; D002621:Chemistry; D007070:Immunoglobulin A / Q000378:metabolism*; D007140:Immunoglobulin Fab Fragments / Q000276:immunology*; D008024:Ligands; D008756:Methylgalactosides / Q000276:immunology*; D008759:Methylglycosides / Q000276:immunology*; D051379:Mice
D000911:Antibodies, Monoclonal; D000941:Antigens; D007070:Immunoglobulin A; D007140:Immunoglobulin Fab Fragments; D008024:Ligands; D008756:Methylgalactosides; D008759:Methylglycosides