title: beta-N-gamma-glutamyl diaminopropionic acid, a convulsant and an inhibitor of brain glutamate decarboxylase.
abstract: The different isomers of the dipeptide beta-N-gamma-glutamyl diaminopropionate inhibit L-glutamate-1-carboxylyase (GAD, EC-4.1.1.15) activity in mouse brain homogenates. The L-D isomer is the most effective as an inhibitor, while the D-D isomer is least inhibitory. The different isomers are neurotoxic to mice and the chick, the L-D isomer being the most toxic. The neurotoxicity of the isomers in mice was also associated with a significant lowering in GAD activity in the brains of convulsing mice.
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology*; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D003292:Convulsants / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology*; D005968:Glutamate Decarboxylase / Q000037:antagonists & inhibitors* / Q000302:isolation & purification; D007536:Isomerism; D007700:Kinetics; D051379:Mice; D013329:Structure-Activity Relationship
chemical_list: D003292:Convulsants; D004151:Dipeptides; C038542:N-gamma-glutamyldiaminopropionic acid; D002262:Carboxy-Lyases; D005968:Glutamate Decarboxylase