Induction of hepatic microsomal drug-metabolizing enzymes by sulfur-containing metabolites of chlorinated benzenes in rats.
3,5-Dichlorophenyl methyl sulfide and its oxidized compounds, metabolites of m-dichlorobenzene, increased the activity of aniline hydroxylase and aminopyrine N-demethylase and the content of cytochromes P-450 and b5 in rat liver microsomes. Hexobarbital sleeping time was reduced by these three compounds. After the administration of the sulfide to rats, 3,5-dichlorophenyl methyl sulfone appeared in blood, liver, and kidneys, and remained detectable in the blood and the tissues between 120 and 240 hr. The sulfone was considered to play a principal role in the induction by these compounds. Other chlorophenyl methyl sulfones also showed similar induction activity.
D000633:Aminopyrine N-Demethylase / Q000096:biosynthesis; D000815:Aniline Hydroxylase / Q000096:biosynthesis; D000818:Animals; D002722:Chlorobenzenes / Q000378:metabolism* / Q000633:toxicity; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004121:Dimethyl Sulfoxide; D004790:Enzyme Induction; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013450:Sulfones / Q000633:toxicity*
D002722:Chlorobenzenes; D004364:Pharmaceutical Preparations; D013450:Sulfones; D003577:Cytochrome P-450 Enzyme System; C025910:dimethyl sulfone; D000815:Aniline Hydroxylase; D000633:Aminopyrine N-Demethylase; D004121:Dimethyl Sulfoxide