Effect of conalbumin on phytomitogen stimulation and E-rosette formation of human peripheral lymphocytes in normal subjects.
An immunological in vitro study was carried out on conalbumin, an iron binding protein structurally similar to lactoferrin, which is a well-known bacterial inhibitor in human milk. Conalbumin itself has been proved to have bacteriostatic activity against a broad spectrum of bacteria responsible for gastrointestinal infections. The activity of conalbumin on the in vitro response to PHA, PWM and Con A and on the E-rosette formation ability of peripheral lymphocytes of 10 normal subjects was studied. The results showed that conalbumin did not affect the lymphocytes' E-rosette formation ability and did not induce blastic transformation of lymphocytes. However, conalbumin was able to produce a significant increase in the in vitro response of lymphocytes to PHA and PWM, suggesting an action on both T and B lymphocytes.
D000328:Adult; D003207:Conalbumin / Q000494:pharmacology*; D004527:Egg Proteins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D037102:Lectins / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012397:Rosette Formation
D004527:Egg Proteins; D037102:Lectins; D003207:Conalbumin