[Sensitivity of the hematopoietic stem cells of anemic animals to actinomycin D].
It was shown on the model of anemic animals by the method of spleen colonies that non-proliferating CFU-S were resistant against the cytotoxic effect of actinomycin D in concentrations 0.04 to 0.4 micrograms/ml. The entry of CFU-S in proliferation was accompanied by a sharp increase of the sensitivity to the antibiotic in a dose blocking DNA-dependent rRNA synthesis.
D000740:Anemia / Q000503:physiopathology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003114:Colony-Forming Units Assay; D003609:Dactinomycin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D006410:Hematopoiesis / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA
D003609:Dactinomycin
Chuvstivitel'nost' stvolovykh krovetvornykh kletok anemicheskikh zhivotnykh k aktinomitsinu D.