Diffusion barriers in skin--a new method of comparison.
Using a method which allows the net barrier potential of skin to be expressed in terms of a 'penetration half-life', skin barriers to nandrolone and allyl oestrenol penetration were compared in human, rat and hamster skin. The ranking order in terms of the net barrier was: human = haired rat greater than or equal to hairless rat greater than hairless hamster. Using the same principles, the net barrier effects of the various layers in whole human skin were also compared. The dermis was only slightly less effective than the stratum corneum as a barrier to diffusion.
D000500:Allylestrenol / Q000378:metabolism; D000818:Animals; D002463:Cell Membrane Permeability; D006224:Cricetinae; D004058:Diffusion; D005260:Female; D006801:Humans; D008297:Male; D008722:Methods; D009277:Nandrolone / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012879:Skin Physiological Phenomena
D009277:Nandrolone; D000500:Allylestrenol