title: Formulation of a stable vidarabine infusion fluid.
abstract: Decomposition of vidarabine in a 5% glucose infusion fluid after steam sterilization was measured by HPLC and TLC analysis. After sterilization for 60 minutes at 100 degrees C and 20 minutes at 120 degrees C no degradation could be observed. A slight but significant degradation was observed after sterilization for 60 minutes at 120 degrees C followed by storage for eight months. Assuming 5% loss of content to be acceptable, it was concluded that a vidarabine infusion fluid can be sterilized for 20 minutes at 120 degrees C and stored at room temperature for at least eight months afterwards.
mesh_terms: D000225:Adenine / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006801:Humans; D007263:Infusions, Parenteral; D014740:Vidarabine / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D014740:Vidarabine; D000225:Adenine