title: [Clinical experience with the implantation of collagen-apatite for local bone regeneration].
abstract: After a short review of the problematic of bone substitution the possibility of bone regeneration induced by implantation of synthetic Apatite and reaffined heterogenic Collagen is displayed especially with an industrial manufactured mixed preparation called "Collapat". Firstly it is referred especially to the comparing animal experience and histological results by Nizard. According to this research fine dispersed Apatite powder has obviously a remarkable osteoinductive effect, which is inhenced by the Collagen component, used especially as a distribution medium. The tract mainly concerns the clinical experiences in human patients with Collagen-Apatite-implantation since October 1979 with the indication of larger bone defects. In 85 patients with totally 94 Collagen-Apatite-implantations in different age groups no incompatibility was seen. In X-ray controls a rapid reestablishment of natural bone structures was observed. The Collagen-Apatite product seems particularly to be apt for the reconstruction of defect cavities as well as for an additive to autologous bone transplantation which by this method can be limited as well in number as in quantity.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001031:Apatites / Q000494:pharmacology; D001847:Bone Diseases / Q000601:surgery; D001859:Bone Neoplasms / Q000601:surgery; D001861:Bone Regeneration / Q000187:drug effects*; D001842:Bone and Bones / Q000473:pathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D003094:Collagen / Q000494:pharmacology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D019736:Prostheses and Implants
chemical_list: D001031:Apatites; D003094:Collagen
vernacular_title: Klinische Erfahrungen mit Collagen-Apatit-Implantation zur lokalen Knochenregeneration.