A new dysfibrinogenemia: fibrinogen Oslo IV.
A family with dysfibrinogenemia is described. The abnormal fibrinogen occurred in three successive generations indicating a dominant hereditary pattern. Thrombin and reptilase times were about twice the normal value. This was shown to be caused by a polymerization defect, fibrinopeptide release being normal. Platelet aggregation was undisturbed, indicating normal platelet-fibrinogen binding. The bleeding time was normal and there was no bleeding tendency. However, an obscure recurrent pulmonary ailment may, or may not, be related to the dysfibrinogenemia. The abnormal fibrinogen was tentatively termed Oslo IV.
D000595:Amino Acid Sequence; D001778:Blood Coagulation Disorders / Q000097:blood*; D005340:Fibrinogen / Q000032:analysis*; D015241:Fibrinogens, Abnormal; D006487:Hemostasis; D006801:Humans
D015241:Fibrinogens, Abnormal; C038281:fibrinogen Oslo IV; D005340:Fibrinogen