Thiazides III. Evidence of dose proportionality of hydrochlorothiazide 25, 50 and 100 mg tablets.
A pilot bioavailability study was carried out where two subjects each were administered a dose of 25, 50 or 100 mg of commercially available hydrochlorothiazide (HCT) tablets. Plasma and urine samples were collected and analyzed by HPLC. A maximum plasma concentration of 50-285 ng/ml was reached in 1-2 hours, and plasma levels declined very rapidly with a half life of about 2-4 hours during first 12 hours period. The AUC was calculated using the trapezodial rule. A linear correlation was seen between the dose administered and amount of drug excreted.
D000328:Adult; D001682:Biological Availability; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage* / Q000378:metabolism; D008297:Male; D013607:Tablets
D013607:Tablets; D006852:Hydrochlorothiazide