title: Chronic D-amphetamine and phencyclidine: effects on dopamine agonist and antagonist binding sites in the extrapyramidal and mesolimbic systems.
abstract: Dopamine agonist and antagonist binding to rat striatal and mesolimbic region tissue was examined in rats chronically treated with D-amphetamine or phencyclidine. In striatum, D-amphetamine produces a down-regulation of [3H]spiroperidol binding but an increase in [3H]ADTN bound (measured in the absence of ascorbate). This suggests that [3H]spiroperidol and [3H]ADTN bind to distinct, separate sites which can be independently regulated.
mesh_terms: D000818:Animals; D002090:Butyrophenones / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D008032:Limbic System / Q000378:metabolism*; D008297:Male; D009281:Naphthalenes / Q000378:metabolism*; D009714:Nucleus Accumbens / Q000378:metabolism; D009830:Olfactory Bulb / Q000378:metabolism; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism*; D013764:Tetrahydronaphthalenes / Q000378:metabolism*
chemical_list: D002090:Butyrophenones; D009281:Naphthalenes; D011954:Receptors, Dopamine; D013764:Tetrahydronaphthalenes; D013134:Spiperone; C011639:ADTN; D010622:Phencyclidine; D003913:Dextroamphetamine; D004298:Dopamine