Effect of oral aromatic retinoid (Ro 10-9359) on human papilloma virus-2-induced common warts.
Persisting human papilloma virus (HPV) 2 induced common warts of a chronic lymphatic leukemia patient were orally treated with aromatic retinoid Ro 10-9359 (Tigason). Clinically, the lesions improved rapidly. Virus-specific cytopathogenic effects (CPE), virus particles and viral DNA were no longer detectable. Therapy was discontinued because of the development of a liposarcoma, which led to a complete relapse of the cutaneous lesions. HPV-2 specific parameters, CPE and viral DNA, were restored. Comparison of the restriction enzyme cleavage patterns revealed that warts before and after therapy contained the same HPV-2 subtype. The implications of the observation on the effect of Tigason on virus-induced papillomas are discussed.
D000284:Administration, Oral; D000368:Aged; D005050:Etretinate / Q000008:administration & dosage*; D006225:Hand; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications; D008297:Male; D012871:Skin Diseases / Q000188:drug therapy* / Q000473:pathology; D014212:Tretinoin / Q000031:analogs & derivatives*; D014860:Warts / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
D014212:Tretinoin; D005050:Etretinate