Prolonged partial cardiopulmonary bypass in rats.
Membrane oxygenators have been shown to be atraumatic during cardiopulmonary bypass. A novel design for a membrane tubing oxygenator originated in this laboratory was used for prolonged partial supportive cardiopulmonary bypass in lambs and displayed excellent biocompatability characteristics. This was miniaturized, to result in a prime volume of 12 ml, in order to investigate the feasibility of prolonged partial supportive cardiopulmonary bypass in rats. The performance of this miniaturized circuit over perfusion periods up to 6 hr is described, with particular reference to hematological changes.
D000818:Animals; D002315:Cardiopulmonary Bypass / Q000379:methods*; D006355:Heart-Lung Machine; D008297:Male; D008904:Miniaturization; D008954:Models, Biological; D010107:Oxygenators, Membrane; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors