Differential agglutination of P388 adriamycin-sensitive and P388 adriamycin-resistant leukemia cells.
Cell surface modification was studied in a subline of murine leukemia resistant to adriamycin (P388/ADR). Lectin-induced agglutination was used as a probe. Agglutination was studied using two plant lectins, wheat germ agglutinin (WGA) and Ricinus communis agglutinin-I (RCA-I). A 7-fold higher amount of WGA and 14-fold higher amount of RCA-I were required to bring about minimum agglutination of P388/S as compared to P388/ADR. The present studies clearly indicate a change in the plasma membrane of P388/ADR cells.
D000371:Agglutination / Q000187:drug effects; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D004317:Doxorubicin / Q000627:therapeutic use*; D004351:Drug Resistance; D007941:Leukemia P388 / Q000188:drug therapy* / Q000503:physiopathology; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051379:Mice
D004317:Doxorubicin