Possible dosage regimens for topical steroids, assessed by vasoconstrictor assays using multiple applications.
The bioavailabilities and activities of three amcinonide preparations and Betnovate cream were assessed using three multiple-dosage regimen vasoconstrictor assays in 10 volunteers. Applications were made once daily, twice daily and every alternate day with an initial three times daily loading dose applied on the first day only. Blanching responses first increased and then decreased due to tachyphylaxis. It is proposed that clinically the most advantageous dosage regimen is a once daily application with no loading dose.
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001623:Betamethasone / Q000031:analogs & derivatives*; D001624:Betamethasone Valerate / Q000008:administration & dosage*; D001681:Biological Assay; D004334:Drug Administration Schedule; D006801:Humans; D012867:Skin / Q000098:blood supply*; D014221:Triamcinolone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014661:Vasoconstriction / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; D014221:Triamcinolone; C012716:amcinonide; D001623:Betamethasone; D001624:Betamethasone Valerate