title: [Interaction of methimazole and quinones. Spectrophotometric determination of methimazole in blood].
abstract: A sensitive method for spectrophotometric determination of methimazole is based on the reaction of this compound with 2,3-dichloro-1,4-naphtoquinone in presence of ammonia. The colour thus formed is stable, reproducible and linear in the range 0,4 to 4 micrograms/ml of methimazole concentration. This method has been employed successfully for estimation of the antithyroid drug in plasma sample with good recovery (75 +/- 2%). The colour is due to formation of a red compound of molecular formula C14H11O2N3S, deduced from elemental analysis and mass spectrum.
mesh_terms: D000641:Ammonia / Q000494:pharmacology; D004347:Drug Interactions; D006801:Humans; D008713:Methimazole / Q000097:blood / Q000494:pharmacology*; D009285:Naphthoquinones / Q000494:pharmacology*; D013053:Spectrophotometry
chemical_list: D009285:Naphthoquinones; D008713:Methimazole; D000641:Ammonia; C007332:dichlone
vernacular_title: Interazione del metimazolo e chinoni. Determinazione spettrofotometrica del metimazolo nel plasma.