title: Skin fibroblasts from humans predisposed to colon cancer are not abnormally sensitive to DNA damaging agents.
abstract: We report here that skin fibroblasts from individuals with hereditary adenomatosis of the colon and rectum (ACR), an autosomal dominant trait, were not abnormally sensitive to x-rays, UV-light or MNNG. ACR cells were also competent in restoring x-rays and UV-light induced damage of SV40 T-antigen expression following infection of these cells by the irradiated virus. We concluded, therefore, that sensitivity to x-rays, UV-light and MNNG can not be used to identify gene-carriers dominantly predisposed to colon cancer.
mesh_terms: D004260:DNA Repair; D004198:Disease Susceptibility; D005347:Fibroblasts / Q000473:pathology; D005736:Gardner Syndrome / Q000235:genetics; D006801:Humans; D007417:Intestinal Polyps / Q000453:epidemiology* / Q000235:genetics; D008769:Methylnitronitrosoguanidine / Q000633:toxicity; D012867:Skin / Q000473:pathology* / Q000528:radiation effects; D014466:Ultraviolet Rays; D014965:X-Rays
chemical_list: D008769:Methylnitronitrosoguanidine