title: Heinz-body hemolytic anemia from the ingestion of crude oil: a primary toxic effect in marine birds.
abstract: Hemolytic anemia developed in young herring gulls and Atlantic puffins given daily oral doses of a Prudhoe Bay crude oil. Anemia developed 4 to 5 days after the initiation of oil ingestion and was accompanied by Heinz-body formation and a strong regenerative response. The data evince a toxic effect on circulating red blood cells involving an oxidative biochemical mechanism and the first clear evidence of a primary mechanism of toxicity from the ingestion of crude oil by birds.
mesh_terms: D000743:Anemia, Hemolytic / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D001715:Bird Diseases / Q000139:chemically induced*; D001717:Birds; D005648:Fuel Oils / Q000009:adverse effects*; D006366:Heinz Bodies / Q000473:pathology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D010578:Petroleum / Q000009:adverse effects*
chemical_list: D005648:Fuel Oils; D010578:Petroleum