title: A new inducible fragile site on chromosome 3(p14.2) in human lymphocytes.
abstract: A fragile site on chromosome 3(p14.2) was found in lymphocytes of two unrelated patients. Expression of the trait with 6%-18% affected cells could only be demonstrated under culture conditions favouring a low concentration of folic acid. Family investigations proved the maternal transmission of the cytologic marker in one case. In contrast to other fragile sites chromatid type aberrations predominated.
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics; D002675:Child, Preschool; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002900:Chromosomes, Human, 1-3; D005260:Female; D005492:Folic Acid / Q000494:pharmacology; D006801:Humans; D007231:Infant, Newborn; D008214:Lymphocytes / Q000648:ultrastructure
chemical_list: D005492:Folic Acid