title: Thinking disorder in depression.
abstract: This experiment demonstrated abstract reasoning deficits in depressed patients and detailed some of the components of cognition that may determine such deficits. Subjects were given a discrimination learning problem in which possible solutions had to be formulated and tested against new information. Depressed subjects performed more poorly on the task than controls. Two types of errors--inability to narrow down the set of possible solutions (poor "focusing") and perseveration on disconfirmed hypotheses--hampered the performance of depressed but not control subjects. While logic, memory, and attention were intact at an elementary level, the inability to coordinate these functions in a complex task appeared to be an important feature of the depressive impairment.
mesh_terms: D000328:Adult; D001288:Attention; D003072:Cognition Disorders / Q000175:diagnosis / Q000523:psychology; D003866:Depressive Disorder / Q000523:psychology*; D004193:Discrimination Learning; D005246:Feedback; D005260:Female; D006801:Humans; D008128:Logic; D008297:Male; D008568:Memory; D011340:Problem Solving; D013850:Thinking