Viability and development of 'tube-locked' mouse embryos.
'Tube-locked' morulae and blastocysts were recovered from the ampulla of the oviduct of centchroman-treated mice between Days 4 and 12 post coitum and transferred to the uteri of pseudopregnant female mice. Pregnancy and implantation rates were lower and the post-implantation resorption rate was higher in the treated than in the control group. There was little difference in the pregnancy or implantation rates between embryos recovered on Days 4 or 12 post coitum, but the resorption rate increased with increasing duration of embryos in the oviducts and was 100% for the Day-12 embryos. The resorption rate was similar even when these embryos were transferred to the sterile uterine horn of unilaterally pregnant mice. Centchroman did not produce any deleterious effect on embryos which survived until Day 19 of pregnancy in foster mothers. The average fetal weight was also comparable to those of control fetuses.
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D002486:Centchroman / Q000494:pharmacology*; D010064:Embryo Implantation / Q000187:drug effects; D020964:Embryo Loss; D004624:Embryo Transfer; D004622:Embryo, Mammalian / Q000187:drug effects* / Q000502:physiology; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D011555:Pseudopregnancy
D001578:Benzopyrans; D002486:Centchroman