Effect of calorie restriction on the fate of hyperplastic liver nodules induced by concurrent administration of lasiocarpine and thioacetamide.
1 Hyperplastic liver nodules were induced in F-344 rats by concurrent administration of lasiocarpine (50 ppm in diet) and thioacetamide (50 mg/kg body weight twice weekly) for 15 weeks. 2 The effect of carbohydrate calorie and total calorie restriction on the fate of hyperplastic liver nodules was examined. 3 The incidence of hepatocellular carcinoma was the same in all groups of rats irrespective of the magnitude of carbohydrate calorie restriction and 50% total calorie restriction. 4 These studies demonstrate that carbohydrate or total calorie restriction has no effect on the progression of hyperplastic nodules to hepatocellular carcinoma.
D000081:Acetamides / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D002149:Energy Intake; D006965:Hyperplasia; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D011763:Pyrrolizidine Alkaloids / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D013853:Thioacetamide / Q000633:toxicity*
D000081:Acetamides; D002273:Carcinogens; D004040:Dietary Carbohydrates; D011763:Pyrrolizidine Alkaloids; D013853:Thioacetamide; C005136:lasiocarpine