Effect of anesthetic or analgesic drugs on lipogenic and lipolytic adipose tissue activities.
The effects of several anesthetic or analgesic agents (halothane, Na thiopental, ketamine, nitrous oxide, xylazine, and procaine) administered in vivo, on swine adipose tissue metabolism were measured. Adipose tissue samples were collected from the subcutaneous depot before and after administration of the anesthetic or analgesic agent. The rate of oxidation of glucose to CO2 and the lipogenic rate, or the basal and stimulated lipolytic rates, were measured on tissue slices incubated in vitro. There were no effects on the oxidation of glucose to CO2 or the incorporation into lipids except by procaine. Procaine depressed (P less than or equal to 0.05) the lipogenic rate (12%) and tended (P less than or equal to 0.1) to depress the oxidative rate (9%). The only observable effect on the lipolytic rates was a tendency (P less than or equal to 0.1) for ketamine to increase the stimulated lipolytic rate. The minimal effects on adipose tissue metabolism reported herein were obtained with short times of compound administration. Several agents (nitrous oxide, procaine, and xylazine) are not recommended because of poor analgesia.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000700:Analgesics / Q000494:pharmacology*; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001706:Biopsy; D005260:Female; D005947:Glucose / Q000378:metabolism; D050356:Lipid Metabolism; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D011343:Procaine / Q000494:pharmacology; D013552:Swine
D000700:Analgesics; D000777:Anesthetics; D011343:Procaine; D005947:Glucose