Dietary effect of omega-3 type polyunsaturated fatty acids on serum and liver lipid levels in rats.
The dietary effect of omega-3 type highly polyunsaturated fatty acid concentrate (PUFA mix) was investigated on cholesterol and triglyceride levels in the serum and liver, and high density lipoprotein cholesterol (HDL-cholesterol) levels in the serum. The PUFA mix prepared from squid liver oil contained about 75% of total omega-3 type fatty acids. In rats fed the normal diet to which 3% PUFA mix was added, the levels of triglyceride, total cholesterol and phospholipid in the serum markedly decreased as compared to rats fed a 3% methyl-oleate diet. However, lipid peroxide values in the liver and serum increased in rats fed PUFA mix-diets. In the hypercholesterolemic rats, a 5% PUFA mix-diet caused growth retardation and a corresponding reduction in food intake. Lipid peroxide in the liver and serum were more elevated in rats fed diets containing 1, 3 and 5% PUFA mix than in rats fed diets containing 5% oleate or 5% linoleate. In all the rats on PUFA mix-diets, there were depression of serum total cholesterol and elevation of serum HDL-cholesterol. The ratio of HDL-cholesterol to total cholesterol increased in proportion to the amounts of dietary PUFA mix. Total cholesterol level in the liver was depressed after PUFA mix feeding.
D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D008076:Cholesterol, HDL; D004041:Dietary Fats / Q000008:administration & dosage*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D050356:Lipid Metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism
D008076:Cholesterol, HDL; D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D008054:Lipid Peroxides; D008075:Lipoproteins, HDL; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol