title: [Synthesis of N alpha-(4-methylbenzoyl)-4-amidinophenyl-alaninamides and -esters].
abstract: To test their inhibitory activity against serine proteinases, especially thrombin, in comparison to the very potent N alpha-tosyl-4-amidinophenylalaninamides, the authors synthetized the compounds named in the title, which contain the p-toluoyl residue in place of the tosyl residue. These compounds were prepared from 4-cyanophenyl-alanine (1) by N-acylation to 2 and formation of the active ester 3 which was aminolyzed. The amides thus obtained were converted, via the thioamides and the thioimidic acid ester salts, to the amidine hydroiodides 16-19. The methyl ester 21 was afforded from 2 by means of the Pinner reaction.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D011480:Protease Inhibitors / Q000138:chemical synthesis*
chemical_list: D011480:Protease Inhibitors; D010649:Phenylalanine
vernacular_title: Synthese von N alpha-(4-Methylbenzoyl)-4-amidinophenylalaninamiden und -ester.