Intrahypothalamic 5,7-dihydroxytryptamine facilitates feminine sexual behavior and decreases [3H]imipramine binding and 5-HT uptake.
5,7-Dihydroxytryptamine (5,7-DHT) injected into the hypothalamus facilitated feminine sexual behavior in ovariectomized, estrogen-treated female rats beginning 9 days post-lesion. 5,7-DHT treatment was associated with decreased [3H]5-HT but not [3H]NE uptake in the whole hypothalamus and with decreased [3H]-imipramine binding in some hypothalamic nuclei. These data provide the first demonstration using chemical lesions that 5-HT neurons may exert tonic inhibition on hormone-mediated feminine sexual behavior.
D015116:5,7-Dihydroxytryptamine / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D004102:Dihydroxytryptamines / Q000008:administration & dosage*; D005260:Female; D007031:Hypothalamus / Q000378:metabolism*; D007099:Imipramine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D014316:Tritium
D004102:Dihydroxytryptamines; D014316:Tritium; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D007099:Imipramine