Anti-thrombotic effect of very low doses of acetyl salicylic acid in rats.
The anti-thrombotic effect of acetyl salicylic acid (ASA) was studied using the following experimental model: a silk thread was inserted in an extracorporeal shunt between the right carotid artery and the opposite jugular vein. A thrombus developed around the thread which was weighed at 10 minutes intervals. ASA inhibits the development of the thrombus at a dose of 3.1 mg/kg. When the dose was increased the anti-thrombotic effect disappeared. These results suggest that ASA may be an effective antithrombotic agent in man if the dosage is based on pharmacological data.
D000818:Animals; D001241:Aspirin / Q000008:administration & dosage*; D001792:Blood Platelets / Q000187:drug effects; D002339:Carotid Arteries; D004305:Dose-Response Relationship, Drug; D005112:Extracorporeal Circulation; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D007601:Jugular Veins; D008297:Male; D010976:Platelet Count; D051381:Rats; D013927:Thrombosis / Q000517:prevention & control*
D005343:Fibrinolytic Agents; D001241:Aspirin