title: In vitro absorption of [14C]leucine during inflammation and the effect of antiinflammatory drugs in the jejunum of rats.
abstract: 1. Inflammation was induced in the hindlegs of rats by formalin injection and the in vitro absorption of [14C]leucine was studied. 2. Treatment of rats with formalin caused a reduction in the in vitro absorption of leucine from the mucosa of jejunum. 3. Oral administration of oxyphenbutazone or a herbal anti-inflammatory drug (Withania somnifera) prior to formalin injection resulted in no alteration in the jejunal absorption of [14C]leucine.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D007249:Inflammation / Q000378:metabolism*; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000378:metabolism; D007930:Leucine / Q000378:metabolism*; D008297:Male; D010113:Oxyphenbutazone / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D007930:Leucine; D010113:Oxyphenbutazone