Hypoxia, calcium, and contracture as mediators of myocardial enzyme release.
During calcium-free perfusion, anoxic contracture of myocardial cells causes cells to separate at intercalated disks and leads to an energy-independent enzyme release in the absence of active transmembrane calcium fluxes. It is proposed that contracture mediates membrane damage and enzyme release in cells sensitized to the calcium paradox.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D000860:Hypoxia / Q000201:enzymology*; D009200:Myocardial Contraction; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
D002118:Calcium