Characterization of the aortic collagens in guinea pigs with chronic vitamin C deficiency.
Marginal vitamin C deficiency lasting 19 weeks caused hypercholesterolemia and hypertriglyceridemia in guinea pigs. In the thoracic aorta of deficient animals a moderate decline of type I and an increase of type III collagen was observed. Both types of collagen isolated from deficient aortas proved to be slightly underhydroxylated.
D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism*; D001206:Ascorbic Acid Deficiency / Q000378:metabolism*; D002908:Chronic Disease; D003094:Collagen / Q000378:metabolism*; D006168:Guinea Pigs; D006937:Hypercholesterolemia / Q000097:blood; D006949:Hyperlipidemias / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D014280:Triglycerides / Q000097:blood
D008055:Lipids; D014280:Triglycerides; D003094:Collagen