Loss of hepatic monooxygenase activities, glutathione, and 'green pigment' formation after the administration of vinyl-cyclooctane to mice.
Vinylcyclooctane, when administered to mice at 500 mg/kg, produced reduction of microsomal cytochrome P-450, heme, aminopyrine-N-demethylase and ethoxycoumarin-O-deethylase activities with respect to control values; furthermore the hepatic reduced glutathione level was depleted suggesting that glutathione is involved in the vinylcyclooctane metabolism. The reduction of cytochrome P-450 and monooxygenase activities was accompanied by the formation of abnormal 'green pigments'.
D000818:Animals; D034242:Cyclooctanes; D003516:Cycloparaffins / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System; D005978:Glutathione / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D010105:Oxygenases / Q000378:metabolism*; D010860:Pigments, Biological / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism
D034242:Cyclooctanes; D003516:Cycloparaffins; D010860:Pigments, Biological; C038434:vinylcyclooctane; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D005978:Glutathione; D015032:Zinc