Cimetidine-induced mania in depressed patients.
Two psychiatric patients whose illnesses were in remission became hyperactive, euphoric, and agitated following the use of cimetidine. Both patients obtained relief from these symptoms when the drug was discontinued, and one had a recurrence of symptoms when cimetidine treatment was resumed.
D000341:Affective Disorders, Psychotic / Q000139:chemically induced*; D001714:Bipolar Disorder / Q000139:chemically induced*; D002927:Cimetidine / Q000009:adverse effects*; D006146:Guanidines / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000150:complications / Q000188:drug therapy; D011618:Psychotic Disorders / Q000150:complications
D006146:Guanidines; D002927:Cimetidine