Determination of carcinoembryonic antigen in tissue, serum and urine in patients with transitional cell carcinoma of the urinary bladder.
Carcinoembryonic antigen (CEA) is elevated in urine and/or serum of patients with transitional cell carcinoma (TCC) of the urinary bladder. A group of 26 patients with TCC of the urinary bladder were evaluated with regard to urine/serum CEA levels and CEA tissue content. CEA could be detected in normal, metaplastic and pre-neoplastic urothelium as well as tumor tissue. CEA was mainly localized on cell membranes, but with increasing tumor malignancy and infiltration a shift to cytoplasmatic localized CEA was noted. There was also a decrease in CEA content in the latter group. CEA urine levels were elevated above normal in more advanced tumor stages; however, the values varied greatly between individuals. All serum levels were within normal limits. No correlation could be established between urine/serum CEA levels and CEA tissue content.
D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D002295:Carcinoma, Transitional Cell / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000276:immunology* / Q000473:pathology
D002272:Carcinoembryonic Antigen