Effects of four retinoids in N-nitrosobis(2-oxopropyl)amine-treated hamsters.
Four synthetic retinoids were evaluated with regard to chemo-prevention of pancreatic carcinomas in carcinogen-treated hamsters. Syrian golden hamsters were given two injections of N-nitrosobis(2-oxopropyl)amine (20 mg/kg) and then were fed retinoid-supplemented diets for 1 year. The incidence of pancreatic carcinomas was lower in six of eight retinoid-fed groups than in the control group, although the differences were not statistically significant. The lowest incidence was observed in groups fed N-(4-pivaloyloxyphenyl)retinamide and N-(2-hydroxypropyl)retinamide. Testicular atrophy with decreased spermatogenesis was noted in males fed N-(2-hydroxypropyl)retinamide, N-(3-hydroxypropyl)retinamide, and N-(2,3-dihydroxypropyl)retinamide.
D000230:Adenocarcinoma / Q000139:chemically induced; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002278:Carcinoma in Situ / Q000139:chemically induced; D006224:Cricetinae; D004032:Diet; D005260:Female; D008113:Liver Neoplasms / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control; D009602:Nitrosamines; D009929:Organ Size; D010190:Pancreatic Neoplasms / Q000139:chemically induced* / Q000517:prevention & control; D012737:Sex Factors; D014801:Vitamin A / Q000031:analogs & derivatives*
D009602:Nitrosamines; D014801:Vitamin A; C013622:nitrosobis(2-oxopropyl)amine