Reversibility of neurological deficits in vitamin B12 deficiency.
A female patient with subacute neurological deficits secondary to an hereditary vitamin B12 deficiency was repeatedly examined clinically and neurophysiologically. It is concluded that neurological normalization after treatment with vitamin B12 also occurs within the CNS. Such normalization takes place soon after initiating treatment and probably reflects other neuronal mechanisms that remyelination, i.e. recovery from conduction block in fast somatosensory pathways and/or improvement of synaptic transmission.
D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D005074:Evoked Potentials, Visual / Q000187:drug effects; D005260:Female; D006801:Humans; D008475:Median Nerve / Q000187:drug effects; D008875:Middle Aged; D009046:Motor Neurons / Q000187:drug effects; D009410:Nerve Degeneration / Q000187:drug effects; D009422:Nervous System Diseases / Q000188:drug therapy*; D009431:Neural Conduction / Q000187:drug effects; D012677:Sensation / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects; D013497:Sural Nerve / Q000187:drug effects; D014805:Vitamin B 12 / Q000627:therapeutic use*; D014806:Vitamin B 12 Deficiency / Q000150:complications* / Q000235:genetics
D014805:Vitamin B 12