Embryotoxic effects of 2,3,7,8 tetrachlorodibenzo-p-dioxin administered to female rats before mating.
2,3,7,8-Tetrachlorodibenzo-p-dioxin was administered to female rats by gavage for 2 consecutive weeks at daily doses of 0, 0.125, 0.5, and 2 micrograms/kg. After treatment females were caged with untreated males. All dams were killed on Day 21 of gestation. Their reproductive statuses were recorded and live fetuses were examined for external, visceral, and skeletal malformations. At 0.125 micrograms/kg no effects were observed on both maternal and fetal toxicity; 0.5 micrograms/kg reduced maternal weight gain and increased postimplantation loss. At 2 micrograms/kg the following features became evident: reduction of both maternal weight gain and ovulation rate, increase of pre- and postimplantation loss, and fetal growth retardation. Also, malformed fetuses were observed at this dose level.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004147:Dioxins / Q000633:toxicity*; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D008431:Maternal-Fetal Exchange; D010060:Ovulation / Q000187:drug effects; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D013723:Teratogens
D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D013723:Teratogens