[pH-dependent hemolytic and neuraminidase activity of remantadine-sensitive and -resistant variants of influenza virus].
A comparative study of pH-dependence of hemolytic and neuraminidase activities of four remantadin-sensitive influenza A virus strains CAPV (classical avian plague virus) (H7N7), USSR/090/77 (H1N1), Ann Arbor (H2N2), and Texas (H3N2) and their remantadin-resistant variants was carried out. The original strains were shown to produce hemolysis in a narrow pH range (5.0 and 5.5) and to have maximal neuraminidase activity at the same pH values. In remantadin-resistant variants the optimal pH values for hemolytic and neuraminidase activities were higher by 0.5-1.0 than for the sensitive variants.
D000218:Adamantane / Q000031:analogs & derivatives*; D004352:Drug Resistance, Microbial; D014644:Genetic Variation / Q000187:drug effects*; D006461:Hemolysis; D006863:Hydrogen-Ion Concentration; D009980:Influenza A virus / Q000187:drug effects / Q000201:enzymology*; D009439:Neuraminidase / Q000378:metabolism*; D012299:Rimantadine / Q000494:pharmacology*
D012299:Rimantadine; D009439:Neuraminidase; D000218:Adamantane
pH-zavisimost' gemoliticheskoĭ i neĭraminidaznoĭ aktivnosti chuvstvitel'nykh i ustoĭchivykh k remantadinu variantov virusa grippa.