Experimental right-ventricular infarction in rats by abdominodiaphragmal access to the heart. A new technique in the study of infarcted myocardium.
An abdominodiaphragmal way of producing right-ventricular myocardial infarction is introduced, allowing of ligation of the right-coronary artery and vein without further manipulation of the heart. Of the rats operated upon, 22% died perioperatively. Of the surviving part, 89% had myocardial infarction macroscopically. This method was used to study enzyme decreases in infarcted myocardium. Our biochemical results correlate very well with histological and histobiochemical findings reported by other investigators. Therefore, we conclude that right-coronary artery ligation in rats by transabdominal, transdiaphragmal access to the heart can be a useful way to study biochemical aspects of infarcted myocardium.
D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D003402:Creatine Kinase / Q000378:metabolism; D004195:Disease Models, Animal; D006352:Heart Ventricles; D006884:Hydroxybutyrate Dehydrogenase / Q000378:metabolism; D008026:Ligation; D008297:Male; D009203:Myocardial Infarction / Q000201:enzymology / Q000209:etiology*; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
D006884:Hydroxybutyrate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase