title: Hepatic lesions in patients on anabolic androgenic therapy.
abstract: The histopathological changes in the livers of 11 patients treated with alkylated and nonalkylated anabolic androgenic steroids are presented. The histological changes in the liver included: proliferation of the bile ducts with or without cystic dilatation (9/11), peliosis (8/11), atypical hyperplasia of liver cells (2/11), and tumors (3/11). The latter included one case of cholangiocarcinoma, one of hepatocellular carcinoma, and one of combined cholangiocellular and hepatocellular carcinoma. The pathological changes in the liver in this series suggest a possible relationship between anabolic androgenic steroids and bile duct proliferation and/or cholangiocarcinoma.
mesh_terms: D000368:Aged; D045930:Anabolic Agents / Q000009:adverse effects*; D000741:Anemia, Aplastic / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy*; D008107:Liver Diseases / Q000473:pathology*; D008113:Liver Neoplasms / Q000139:chemically induced / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009277:Nandrolone / Q000009:adverse effects; D010110:Oxymetholone / Q000009:adverse effects; D013739:Testosterone / Q000009:adverse effects / Q000031:analogs & derivatives
chemical_list: D045930:Anabolic Agents; D013739:Testosterone; D009277:Nandrolone; C004648:testosterone enanthate; D010110:Oxymetholone