Toxicity investigation of fenbendazole, an anthelmintic of swine.
The toxicity of fenbendazole, an anthelmintic for use in swine, was tested by feeding 8 growing pigs 2,000 mg of fenbendazole/kg of body weight daily for 14 days. A transient leukopenia developed on day 6, but values returned to base line on day 18, 4 days after discontinuation of dosing. Sorbitol dehydrogenase values were significantly (P less than 0.05) increased from day 4 and returned to base line on day 20. Marked gross or histopathologic lesions were not found.
D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D001562:Benzimidazoles / Q000633:toxicity*; D005260:Female; D005273:Fenbendazole / Q000633:toxicity*; D007064:L-Iditol 2-Dehydrogenase / Q000032:analysis; D007970:Leukopenia / Q000139:chemically induced; D013552:Swine
D001562:Benzimidazoles; D005273:Fenbendazole; D007064:L-Iditol 2-Dehydrogenase; D000469:Alkaline Phosphatase