Hemolytic anemia in the mouse. Report of a new mutation and clarification of its genetics.
A new mutation causing spherocytic, hemolytic anemia has been discovered in the house mouse. It is inherited as a single autosomal recessive gene, allelic with both sph and ha, which, in turn, were shown to be allelic with each other. A revised nomenclature for the three apparent alleles is proposed: sph (formerly sph), sphha (formerly ha), and sph2Bc (the new mutation). Like the other murine hemolytic anemias, sph2Bc involves a defect in the red blood cell membrane protein, spectrin.
D000483:Alleles; D000745:Anemia, Hemolytic, Congenital / Q000097:blood / Q000235:genetics / Q000662:veterinary*; D000818:Animals; D005808:Genes, Recessive; D051379:Mice; D008815:Mice, Inbred Strains; D009154:Mutation; D012376:Rodent Diseases / Q000235:genetics*; D013049:Spectrin / Q000235:genetics
D013049:Spectrin