title: [Dissolution of gallstones based on 6 months treatment with a single daily dose of ursodeoxycholic acid].
abstract: 51 patients with radiolucent gallstones of diameter less than or equal to 15 mm were treated for 6 months with a new form of ursodeoxycholic acid (UDCA) in a single dose of 450 mg at bedtime. This new form has 3 components with fractionate liberation. The rate of partial and complete dissolution after 6 months was 63.4%, reaching 85% for gallstones of less than 5 mm diameter. The results show that a single dose of 450 mg UDCA at bedtime is as effective as UDCA at mealtimes in the dissolution of radiolucent gallstones. Administration of the drug once a day should be more acceptable to patients.
mesh_terms: D002769:Cholelithiasis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D003840:Deoxycholic Acid / Q000031:analogs & derivatives*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use*
chemical_list: D003692:Delayed-Action Preparations; D003840:Deoxycholic Acid; D014580:Ursodeoxycholic Acid
vernacular_title: Dissolution de lithiase vésiculaire après 6 mois de traitement par dose journalière unique d'acide ursodésoxycholique.