Selective increased tissue histamine levels in tumour-bearing rodents.
Histamine levels increased in the fundus of mice bearing a primary 3-methylcholanthrene-induced fibrosarcoma, and in the ventral skin, skeletal muscle and rumen of rats bearing a D.M.B.A. induced mammary adenocarcinoma; they did not increase in the tissues of mice bearing a McC3-1 fibrosarcoma (38th passage) or a Lewis lung carcinoma before the appearance of metastasis, but an increase in histamine levels was observed in dorsal skin, ventral skin and fundus, after the appearance of metastasis.
D000818:Animals; D005260:Female; D005354:Fibrosarcoma / Q000032:analysis; D006632:Histamine / Q000032:analysis*; D008175:Lung Neoplasms / Q000032:analysis; D008325:Mammary Neoplasms, Experimental / Q000032:analysis; D008748:Methylcholanthrene; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D008748:Methylcholanthrene; D006632:Histamine