Fluoro-substituted N-nitrosamines. 6. carcinogenicity of N-nitroso-(2,2,2-trifluoroethyl)-ethylamine in rats.
N-Nitroso-(2,2,2-trifluoroethyl)ethylamine (F-3-NDEA) was tested for carcinogenic activity in male Sprague-Dawley rats at 4 dose levels. The compound was given by gavage twice weekly. Treatment related tumors were observed in all experimental groups and appropriate dose-response relations were seen. The main tumor localisations were the esophagus and the nasal cavity. F-3-NDEA therefore is carcinogenic in rats after oral administration, a biological effect to be expected since it had been shown earlier that this compound is enzymatically activated by dealkylation and is weakly mutagenic in bacterial assay systems. A change in organotropism is observed when comparing carcinogenicity of F-3-NDEA with the predominantly hepatocarcinogenic activity of parent N-nitrosodiethylamine.
D000818:Animals; D002273:Carcinogens; D004947:Esophagus / Q000473:pathology; D007928:Lethal Dose 50; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D009296:Nasal Cavity / Q000473:pathology; D009336:Necrosis; D009603:Nitroso Compounds / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; D009603:Nitroso Compounds; C038526:N-nitroso-(2,2,2-trifluoroethyl)ethylamine