Beneficial effect of labetalol in hypertensive patients with angina pectoris.
Labetalol (Trandate; Allen & Hanbury) was administered to 17 hypertensive patients with angina pectoris, which had persisted despite blood pressure control on treatment including beta-blocking agents. In comparison with placebo, labetalol significantly reduced the frequency and severity of attacks of angina pectoris, without further improvement in control of blood pressure at rest, during isotonic exercise or on performance of the cold pressor test. Labetalol significantly reduced blood pressure levels during isometric exercise but did not reduce the systolic pressure- heart rate product. Labetalol improved the angina without evidence of causing a reduction of cardiac work (and presumably oxygen consumption by the myocardium) in comparison with the other antihypertensive agents used in this study. A possible mechanism whereby labetalol increases myocardial blood supply in hypertensive patients with angina pectoris is by an increase in coronary perfusion due to its vasodilator action.
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000150:complications / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007741:Labetalol / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D004983:Ethanolamines; D007741:Labetalol