Dopamine excretion during natriuresis of starvation.
Five obese subjects were studied when they were on a 3.35 MJ (800 kcal)-diet, 1.67 MJ (400 kcal) diet and during total starvation. Urine excretion of sodium and dopamine and plasma renin activity (PRA) and plasma aldosterone levels were measured. Urine sodium excretion increased from 88 +/- 9.8 mmol/d before starvation to 150 +/- 15.7 mmol/d on day 4 of starvation. Dopamine excretion increased from 0.92 +/- 0.23 mumol/d before starvation to 1.56 +/- 0.24 mumol/d on day 1 of starvation (P less than 0.01). These results suggest that dopamine excretion is increased in early starvation and may play a role in the natriuresis of starvation.
D000328:Adult; D000450:Aldosterone / Q000097:blood; D004038:Diet, Reducing; D004298:Dopamine / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009318:Natriuresis; D009765:Obesity / Q000378:metabolism; D013217:Starvation; D013997:Time Factors
D000450:Aldosterone; D004298:Dopamine