title: Thermal stability of DNA interacting with furazolidone and Cu(II) ions.
abstract: Furazolidone, on complexing with DNA, led to its thermal stabilization. The increase in transition temperature of DNA (delta Tm) increased linearly with % A--T content. Increasing concentration of Cu(II) ions progressively lowered the transition temperature of DNA, but Cu(II) ions were not equally effective in lowering the transition temperature of furazolidone-DNA complex. When equimolar amounts of Cu(II) ions and furazolidone were used, the stabilisation effects of furazolidone prevailed over the destabilisation effect of Cu(II) ions.
mesh_terms: D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D003300:Copper; D004247:DNA; D004269:DNA, Bacterial; D004355:Drug Stability; D005664:Furazolidone; D006358:Hot Temperature; D007700:Kinetics; D009691:Nucleic Acid Denaturation; D013950:Thymus Gland
chemical_list: D004269:DNA, Bacterial; D005664:Furazolidone; D003300:Copper; D004247:DNA