[Electrocardiographic changes induced by various analogs of radicinin].
The action of some radicinin analogues has been studied on the ECG in the rat. The most active compound is 2,3-dihydro-2, 7-dimethyl-4H,5H-pyrano [4,3-b]pyran-4,5-dione (II) which induced a significant increase of the heart rate (HR) and an evident prolongation of the PR interval, especially at the highest dose. A slight but lasting increase in HR is caused by compound (VII),3-hexanoyl-4-hydroxy-6-methyl-2H-pyran-2-one, while the compound (III), 7,8-dihydro-2,7-dimethyl-4H,5H-pyrano-[4,3-b]pyran-4,5-dione caused a small prolongation of the PR time. No significant modifications are caused by the other five compounds tested.
D000818:Animals; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D011714:Pyrans / Q000494:pharmacology*; D011753:Pyrones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D011714:Pyrans; D011753:Pyrones; C009157:radicinin
Modificazioni elettrocardiografiche indotte da alcuni analoghi della radicinina.