[Effect of fenamin and haloperidol on conditioned activity of neurons of the motor cortex and striopallidal system].
The activity of neurones in the motor cortex, caudate nucleus, putamen and globus pallidus was studied during elaboration of motor conditioned reflexes to time in rabbits, treated with 1-amphetamine and haloperidol. Mechanisms of reproduction of cells trace activity in the reflex to time at the omission of trials, reacted to 1-amphetamine by increasing the intensity of reactions in the motor cortex and inactivation in putamen cells. The curve of dynamics of intensity changes of trace discharges in the course of a series of trials omissions remained unaltered only in motor cortex; in the other structures it significantly differed from the norm of intact animals. Haloperidol depressed the mechanisms of reproduction of trace reactions of the globus pallidus cells, and made them almost fully inactive in the motor cortex; the putamen neurones reacted to haloperidol by an increase of trace reactions intensity. Against the background of the animal chronic 1-amphetamine intoxication, haloperidol normalized the dynamics and intensity of trace activity. "Therapeutic" effect of haloperidol was most distinctly expressed in the motor cortex and putamen cells, less--in the caudate nucleus and was completely absent in the globus pallidus.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects*; D003342:Corpus Striatum / Q000187:drug effects*; D004597:Electroshock; D005917:Globus Pallidus / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology*; D009044:Motor Cortex / Q000187:drug effects*; D011699:Putamen / Q000187:drug effects; D011817:Rabbits; D013016:Sound
D000661:Amphetamine; D006220:Haloperidol
Vliianie fenamina i galoperidola na uslovnuiu aktivnost' neĭronov dvigatel'noĭ kory i striopallidarnoĭ sistemy.