title: Changes in plasma protein profiles in serum and in liver DNA synthesis of rats following administration of alpha-amanitin, phalloidin and/or carbon tetrachloride.
abstract: The aim of the present study is to investigate the capacity of damaged rat liver cells to respond to a second inflammation by a change in plasma protein profile, while the first inflammatory process is in progress. Quantitation of these effects would be useful, especially in situations where patients are suffering from complications due to emergence of a new pathological factor. We therefore studied the effect of phalloidin on rat livers already made necrotic by oral intubation of CCl4. Our data showed that a decrease in acute-phase response does not necessarily always imply healing, but may also be indicative of a second pathological complication.
mesh_terms: D000546:Amanitins; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D004247:DNA / Q000096:biosynthesis*; D007122:Immunoelectrophoresis; D008099:Liver / Q000378:metabolism*; D010590:Phalloidine; D051381:Rats; D011919:Rats, Inbred Strains; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors
chemical_list: D000546:Amanitins; D001798:Blood Proteins; D010590:Phalloidine; D004247:DNA; D013936:Thymidine