Labeling with indium-111 has detrimental effects on human lymphocytes: concise communication.
When lymphocytes from human peripheral blood were labeled with In-111 oxinate, several of their properties appeared to be affected. The spontaneous release of the radionuclide was found to be relatively high. Labeled lymphocytes showed a decreased proliferative capacity, dependent on the dose of the label. Cytogenetic studies revealed that In-111 oxinate induces severe chromosomal aberrations. These results emphasize the need for great caution in the use of the In-111 label for studies on lymphocyte traffic in humans.
D002455:Cell Division / Q000528:radiation effects; D002869:Chromosome Aberrations; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007204:Indium / Q000009:adverse effects*; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects*; D011868:Radioisotopes / Q000009:adverse effects*
D011868:Radioisotopes; D007204:Indium