GABA or sodium-bromide-induced plasticity of neurites of mouse neuroblastoma cells in culture. A quantitative study.
Differentiated C1300 mouse neuroblastoma cells were treated with 10(-4)-10(6) M gamma-aminobutyric acid (GABA) and/or sodium bromide (NaBr) for 2 days and then fixed. Quantitative studies revealed an increase in the length and branching of the processes, as well as an increase in the number of cells when compared to the controls. It is suggested that the above changes contribute to the augmentation of specialized contacts between cells and processes as well as the further maturation of the primitive stages of synaptogenesis as discussed.
D000818:Animals; D001965:Bromides / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D002999:Clone Cells / Q000648:ultrastructure; D051379:Mice; D009374:Neoplasms, Experimental / Q000648:ultrastructure; D009447:Neuroblastoma / Q000648:ultrastructure*; D009474:Neurons / Q000187:drug effects* / Q000648:ultrastructure; D012964:Sodium / Q000494:pharmacology*; D017670:Sodium Compounds; D013569:Synapses / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D001965:Bromides; D017670:Sodium Compounds; D005680:gamma-Aminobutyric Acid; D012964:Sodium; C027938:sodium bromide