Ovarian tumors of probable wolffian origin. A report of 11 cases.
The clinical and pathological features of 11 ovarian tumors of probable wolffian origin are reported. The age of the patients ranged from 28 to 64 years (average 50 years). The presenting manifestation was abdominal swelling in five cases; in the remaining six cases the tumors were discovered on physical examination. Ten of the tumors were Stage Iai; the 11th, which contained foci of undifferentiated carcinoma, was Stage III. On gross examination the specimens were either solid or solid and cystic. Microscopical examinations revealed epithelial cells that lined cysts, lined or filled tubules, or grew in a diffuse pattern. Mitotic activity was low in the tumors of nine patients, eight of whom were known to be alive and free of disease from 1 to 15 years postoperatively (average 5 years); the ninth patient has been lost to follow-up. One patient whose tumor had a high mitotic rate (13/10 high-power fields) has bilateral pulmonary metastases 8 years postoperatively. The final patient, whose tumor was Stage III and contained foci of undifferentiated carcinoma, has been lost to follow-up.
D000328:Adult; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*; D014928:Wolffian Ducts / Q000473:pathology*