Effects of ion-containing liposomes upon the chemoafferent activity of the rabbit carotid body superfused in vitro.
The effects of calcium concentration changes in carotid body cells on the chemoreceptor discharges were studied in vitro on carotid bodies removed from anaesthetized rabbits. Addition of calcium-containing liposomes to the superfusing medium increased the chemoreceptors' discharges. This effect was abolished by hyperoxia or when EGTA-containing liposomes were simultaneously added with the calcium-containing liposomes. A histological control with ferritin-enriched liposomes showed that the liposome content was transferred into the cellular elements of the preparation except the nerve endings. Results suggest a relationship between calcium concentration changes in carotid body cells and chemoafferent activity.
D000818:Animals; D002344:Carotid Body / Q000187:drug effects* / Q000648:ultrastructure; D002628:Chemoreceptor Cells / Q000187:drug effects*; D004594:Electrophysiology; D005293:Ferritins; D066298:In Vitro Techniques; D008081:Liposomes / Q000494:pharmacology*; D008722:Methods; D008854:Microscopy, Electron; D010477:Perfusion; D011817:Rabbits
D008081:Liposomes; D005293:Ferritins