A new pathway of acrolein metabolism in rats.
The excretion of metabolites of acrolein in rat urine after single oral administration of 10 mg/kg was investigated. S-Carboxyethylmercapturic acid (S-carboxyethyl-N-acetyl-cysteine), or S-(propionic acid methyl ester)mercapturic acid, was found as the major metabolite. An unidentified metabolite was found in expired air. Acrylic acid and methyl acrylate are suggested as intermediates in the metabolism of acrolein.
D000171:Acrolein / Q000378:metabolism*; D000447:Aldehydes / Q000378:metabolism*; D000818:Animals; D005260:Female; D008745:Methylation; D051381:Rats; D011919:Rats, Inbred Strains
D000447:Aldehydes; D000171:Acrolein