Modulation of platelet thromboxane and malonaldehyde by dietary vitamin E and linoleate.
Thromboxane (TXB2) and malonaldehyde (MDA) production by thrombin-stimulated washed platelet were evaluated in rats fed 6 combinations of dietary vitamin E (0, 100, 1000 ppm) and linoleate (6.5 and 17.0 en%) for 23 weeks. The molar ratio of MDA:TXB2 was consistently near 3 in all groups studied. In animals receiving the lower linoleate diets, TXB2 and MDA synthesis were inversely related to the dietary vitamin E concentrations and the levels of MDA and TXB2 were positively correlated (r = 0.99) with decreasing vitamin E in the diet. High dietary linoleate (17.0 en%), independent of vitamin E status, reduces TXB2 and MDA synthesis. The importance of dietary antioxidant on platelet prostanoid synthesis is discussed.
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology; D008041:Linoleic Acids / Q000494:pharmacology*; D008297:Male; D008314:Malonates / Q000096:biosynthesis*; D008315:Malondialdehyde / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013929:Thromboxane B2 / Q000096:biosynthesis; D013931:Thromboxanes / Q000096:biosynthesis*; D014810:Vitamin E / Q000494:pharmacology*
D004041:Dietary Fats; D008041:Linoleic Acids; D008314:Malonates; D013931:Thromboxanes; D014810:Vitamin E; D008315:Malondialdehyde; D013929:Thromboxane B2