title: Difference in polynucleation of cultured cells from human mammary tumors and normal mammary glands on treatment with cytochalasin B.
abstract: In order to study the biological nature of various mammary tumors, differences in the formation of polynuclear cells after the administration of cytochalasin B were investigated in cultures of human mammary tumors and normal mammary gland. When cytochalasin B was applied to the cultures, polynuclear cells increased in all cancer cases (6.1% on average), but relatively little effect was seen in cases of benign tumors and normal mammary gland (less than 1.1% on average). From these results, it appears that the difference in polynucleation on treatment with cytochalasin B may be useful as a biological means to distinguish human malignant and benign mammary tumors.
mesh_terms: D001940:Breast / Q000648:ultrastructure*; D001943:Breast Neoplasms / Q000648:ultrastructure*; D002467:Cell Nucleus / Q000187:drug effects*; D002478:Cells, Cultured; D003571:Cytochalasin B / Q000494:pharmacology*; D005260:Female; D005348:Fibrocystic Breast Disease / Q000473:pathology; D006801:Humans
chemical_list: D003571:Cytochalasin B