Spastic striated external sphincter syndrome imitating recurrent urinary tract infection in females. Effect of long-term alpha-adrenergic blockade with phenoxybenzamine.
6 women with spastic striated external sphincter syndrome were studied urodynamically and subsequently treated with an alpha-adrenoceptor-blocking agent. Symptoms were abolished, and prolonged, fluctuating flow curves were nearly normalized by phenoxybenzamine, 15 mg daily, in 5 of 6 patients despite the unchanged spasticity of the external striated urethral sphincter.
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D009128:Muscle Spasticity / Q000188:drug therapy*; D010643:Phenoxybenzamine / Q000627:therapeutic use*; D012008:Recurrence; D013577:Syndrome; D001745:Urinary Bladder Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D014552:Urinary Tract Infections / Q000175:diagnosis; D014563:Urodynamics / Q000187:drug effects
D010643:Phenoxybenzamine