title: Toxic shock syndrome caused by staphylococcal enterotoxin B. A report of 2 cases in children.
abstract: Two children with osteomyelitis, staphylococcal septicaemia and toxic shock syndrome (TSS) are reported. Both patients presented with fever, shock, scarlatiniform rash and diffuse mucositis. The multi-organ dysfunction which characterizes this syndrome was apparent in both patients, who had jaundice, functional renal impairment, diffuse myalgia and non-localizing neurological signs. One child developed toxic myocarditis and the other thrombocytopenia. Both showed a significant rise in antibody titre to enterotoxin B produced by the offending staphylococci, suggesting that this toxin was responsible for the TSS.
mesh_terms: D002648:Child; D004768:Enterotoxins; D005260:Female; D006801:Humans; D008297:Male; D010019:Osteomyelitis / Q000150:complications*; D012772:Shock, Septic / Q000209:etiology*; D013203:Staphylococcal Infections / Q000150:complications*; D013211:Staphylococcus aureus / Q000378:metabolism; D013577:Syndrome
chemical_list: D004768:Enterotoxins