Influence of acarbose on hyperglycemia induced by various carbohydrates in rats and oral starch tolerance in monkeys.
Acarbose, an alpha-glycosidehydrolase inhibitor, reduced hyperglycemia after an oral sucrose or starch load in the rat. The compound showed weaker activity in inhibiting maltose-induced hyperglycemia and no effect on glucose or lactose tolerance in the rat. In the Cebus monkey, the oral starch tolerance curve was significantly inhibited by acarbose at a dose comparable to that showing activity in man. Therefore, the Cebus monkey appears to be a suitable animal model for studying agents which affect starch tolerance in man.
D020909:Acarbose; D000818:Animals; D002428:Cebus; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D006943:Hyperglycemia / Q000139:chemically induced / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D009844:Oligosaccharides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013213:Starch / Q000378:metabolism*; D014312:Trisaccharides / Q000494:pharmacology*
D004040:Dietary Carbohydrates; D007004:Hypoglycemic Agents; D009844:Oligosaccharides; D014312:Trisaccharides; D013213:Starch; D020909:Acarbose