Endemic Balkan nephropathy, a slow virus disease?
Serum samples from patients with endemic Balkan nephropathy (EBN) were inoculated intraperitoneally to four species of laboratory animals. It was only in the guinea pig that a serially transmissible experimental disease occurred, after a long incubation period. The morphopathological features in the guinea pig were similar to those encountered in the terminal phase of human EBN. The hypothesis that EBN might be a slow virus disease is discussed.
D000818:Animals; D001449:Balkan Nephropathy / Q000209:etiology* / Q000473:pathology / Q000635:transmission; D001485:Basement Membrane / Q000473:pathology; D006224:Cricetinae; D006168:Guinea Pigs; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology; D051379:Mice; D009395:Nephritis, Interstitial / Q000209:etiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012897:Slow Virus Diseases / Q000473:pathology