Resistance to lysis of erythrocytes containing haemoglobin C--detected in a differential white cell counting system.
Erythrocytes containing haemoglobin C do not lyse normally in the peroxidase channel of the Technicon H6000 automated cell counter. This interferes with the normal function of the channel and results in a characteristic abnormal pattern. This correlates with a reduced osmotic fragility of the red cells.
D000755:Anemia, Sickle Cell / Q000097:blood; D002469:Cell Separation; D004912:Erythrocytes / Q000032:analysis*; D006444:Hemoglobin C / Q000032:analysis*; D006445:Hemoglobin C Disease / Q000097:blood*; D006461:Hemolysis; D006801:Humans; D007958:Leukocyte Count; D009996:Osmotic Fragility
D006444:Hemoglobin C