Intravitreal kainic acid permanently eliminates off-pathways from chicken retina.
Kainic acid rapidly suppresses both ON- and OFF-visually evoked responses in the tectum after injection into the vitreous of chicken eyes. One week after injection the OFF-responses were still suppressed, while ON-responses were detected of similar magnitude but of simplified form to those of control eyes. It is suggested that kainic acid selectively destroys OFF- rather than ON-bipolar cells, while the simplification of the ON-responses is due to the destruction of amacrine cells.
D000818:Animals; D002645:Chickens; D005074:Evoked Potentials, Visual / Q000187:drug effects; D007608:Kainic Acid / Q000633:toxicity*; D009474:Neurons / Q000187:drug effects; D011759:Pyrrolidines / Q000633:toxicity*; D012160:Retina / Q000187:drug effects*; D012165:Retinal Ganglion Cells / Q000187:drug effects; D013477:Superior Colliculi / Q000187:drug effects*; D014795:Visual Pathways / Q000187:drug effects; D014822:Vitreous Body / Q000187:drug effects
D011759:Pyrrolidines; D007608:Kainic Acid