title: [Effect of tryptophan excess in a diet on amino acid composition of skin collagen and on an initial stage of protein biosynthesis in rat liver].
abstract: Protein deficiency and tryptophane load against its background lead to the acid-soluble collagen synthesis in the rat skin. The amino acid composition of the collagen differs from the norm. This is accompanied by changes in the free amino acid pool of blood serum and liver, under tryptophane load the free amino acids pool of the liver increasing twice as high. At the same time protein deficiency increases and tryptophane load decreases the level of tRNA amino acylation with tryptophane in the animal liver. Thus, protein deficiency and tryptophane load against its background cause deep changes in the protein biosynthesis.
mesh_terms: D000596:Amino Acids / Q000097:blood / Q000378:metabolism*; D000818:Animals; D003094:Collagen / Q000378:metabolism*; D004044:Dietary Proteins / Q000008:administration & dosage; D008099:Liver / Q000378:metabolism*; D008297:Male; D014176:Protein Biosynthesis; D011488:Protein Deficiency / Q000378:metabolism; D012343:RNA, Transfer / Q000378:metabolism; D051381:Rats; D012867:Skin / Q000378:metabolism; D014364:Tryptophan / Q000008:administration & dosage*
chemical_list: D000596:Amino Acids; D004044:Dietary Proteins; D014364:Tryptophan; D003094:Collagen; D012343:RNA, Transfer
vernacular_title: Vliianie izbytka triptofana v ratsione na aminokislotnyĭ sostav kollagena kozhi i nachal'nyĭ étap biosinteza belka v pecheni krys.