Cellular toxicity of urinary catheters.
The cellular compatibility of each of several brands of urinary catheters available on the Australian market was measured by means of cell-culture methods, a rabbit intramuscular implant test, and the traditional mouse systemic toxicity test. Good agreement was obtained between the in-vitro tests and the rabbit implant tests (although the cell-culture tests were simpler, more rapid, more sensitive, and quantitative). The mouse systemic toxicity test was insensitive, and detected no toxic samples. The cell-culture and rabbit-implant test results indicated that some urinary catheters can release substances harmful to mammalian cells. Such substances may contribute to the clinical reactions of urethritis and strictures after urethral catheterization.
D000818:Animals; D002478:Cells, Cultured; D003603:Cytotoxins / Q000378:metabolism*; D066298:In Vitro Techniques; D051379:Mice; D011817:Rabbits; D014546:Urinary Catheterization / Q000009:adverse effects*
D003603:Cytotoxins