Role for glucagon as a mineralocorticoid antagonist during the fetal-perinatal period.
The progressive decrease in total body water (TBW) and sodium during the fetal-perinatal period; the normally noted 5-10 per cent largely water weight loss noted in term infants during the first 3-4 days postnatally; and, the even greater TBW and sodium losses incurred by premature infants during the initial post-natal week may, in part, be secondary to a glucagon-mediated, renal distal tubular hyporesponsiveness to aldosterone.
D000450:Aldosterone / Q000097:blood*; D000818:Animals; D001834:Body Water / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D005934:Glucagon / Q000097:blood / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D012084:Renin-Angiotensin System; D012756:Sheep; D014882:Water-Electrolyte Balance
D000450:Aldosterone; D005934:Glucagon