The effects of D-penicillamine on non-immune responses to tissue injury.
D-penicillamine was found to have a pro-inflammatory effect when given to rats during the formation of carrageenan air pouch granulomas or simple air cavity linings. Unlike dexamethasone, D-penicillamine had no effect on the strength of the cavity lining in either system. D-penicillamine had no effect on the chemoattractant properties of the carrageenan-induced exudates or on the responsiveness of cells from such exudates to a chemoattractant. These results suggest that D-penicillamine has a short-term pro-inflammatory effect on non-immune responses to tissue injury, but the mechanism remains unclear.
D000818:Animals; D002351:Carrageenan; D002465:Cell Movement / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology; D006099:Granuloma / Q000139:chemically induced; D007249:Inflammation / Q000473:pathology*; D008297:Male; D010396:Penicillamine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013718:Tensile Strength
D003907:Dexamethasone; D002351:Carrageenan; D010396:Penicillamine