[Ectopic calcifications in adult hypophosphatasia].
The first case of hypophosphatasia in adults reported in Italy (20th in the world) is described with remarks on the epidemiology, pathogenesis and therapeutic possibilities. The formation of renal and cholecystic calculi after long-term, intensive vitamin D and Calcium therapy indicates the limited capacity of pyrophosphate (PPi), even in large doses, to prevent the precipitation in man of calcium and phosphorus and the subsequent formation of ectopic calcifications.
D000368:Aged; D003404:Creatinine / Q000652:urine; D005260:Female; D005265:Femoral Neck Fractures / Q000628:therapy; D005593:Fracture Fixation, Internal; D042882:Gallstones / Q000209:etiology*; D006801:Humans; D007014:Hypophosphatasia / Q000150:complications*; D011859:Radiography; D014545:Urinary Calculi / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery
D003404:Creatinine
Calcificazioni ectopiche in corso di ipofosfatasia dell'adulto.