Kinetics of oral trifluoperazine disposition in man.
The disposition of trifluoperazine (TFP) was studied in five healthy volunteers following oral administration of a 5 mg tablet. Using a very sensitive GC-MS technique plasma TFP concentrations were measured up until 24 h following drug ingestion. Peak plasma concentrations varied widely (range 0.53-3.09 ng ml-1) and were reached 2.8 +/- 0.5 h following ingestion of the TFP tablet. The apparent terminal elimination half-life of TFP was 12.5 +/- 1.4 h. The area under the plasma concentration-time curve differed widely between subjects (range: 5.9-17.6 ng ml-1 h) suggesting large individual differences in the extent of presystemic TFP elimination.
D000284:Administration, Oral; D000328:Adult; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D013607:Tablets; D014268:Trifluoperazine / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
D013607:Tablets; D014268:Trifluoperazine