title: [Polyneuropathy caused by disulfiram poisoning].
abstract: Disulfiram is known to produce toxic encephalopathy and peripheral neuropathy. The case of a 37-year-old alcoholic who attempted to commit suicide by taking 22.5 g disulfiram is described. During the first 6 days after the intoxication he was stuporous and had cerebellar ataxia and dysarthric speech. Then he became comatose, and as he recovered from coma, he showed peripheral neuropathy including diplegia faciei and severe tetraparesis. Denervation potentials were detected in both facial muscles and distal muscles of the upper and lower limbs, while conduction velocity was normal. Axonal degeneration was verified by sural nerve biopsy. In addition neurofilamentous axonopathy was documented. The recovery from his paresis lasted 2 years.
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000534:rehabilitation*; D001369:Axons / Q000187:drug effects; D001706:Biopsy; D003128:Coma / Q000139:chemically induced; D004221:Disulfiram / Q000506:poisoning*; D004576:Electromyography; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000187:drug effects; D009431:Neural Conduction / Q000187:drug effects; D009468:Neuromuscular Diseases / Q000139:chemically induced; D011115:Polyneuropathies / Q000139:chemically induced* / Q000473:pathology; D011782:Quadriplegia / Q000139:chemically induced; D013406:Suicide, Attempted; D013497:Sural Nerve / Q000187:drug effects / Q000473:pathology
chemical_list: D004221:Disulfiram
vernacular_title: Polyneuropathie nach Disulfiram-Intoxikation.