Quantitative correlation between carcinogenicity and sister chromatid exchange induction in vivo for a group of 11 N-nitroso derivatives.
The quantitative correlation between induction of sister chromatid exchanges (SCEs) in vivo and carcinogenic potency was examined for 11 nitroso derivatives and was compared with the correlation of alkaline DNA fragmentation in liver DNA in vivo and with the Ames test. The correlation between DNA adducts and SCEs was also evaluated. DNA damage was slightly more predictive and the Ames test less predictive than SCE evaluation. The predictivity of these tests for this class of compounds was compared with the predictivity shown for different classes of chemical compounds.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002273:Carcinogens; D003434:Crossing Over, Genetic / Q000187:drug effects*; D004247:DNA; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009603:Nitroso Compounds / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D002273:Carcinogens; D009603:Nitroso Compounds; D004247:DNA