Cholesterol esters in rat brain infected with acute measles encephalitis: concentration and fatty acid composition.
The present study deals with the concentration and fatty acid composition of cholesterol esters in rat brains infected experimentally with measles virus to induce acute encephalitis. The left side of the cerebrum, as well as other portions of the brain, when inoculated percutaneously contained a large amount of cholesterol esters. The major fatty acids from the esters in the brain were C16:0, C16:1, C18:0, and C18:1; those from the serum were C18:1, C18:2, and C20:4. This result indicates that cholesterol esters may not come from serum but can be synthesized in situ, even in the brain with acute viral infection.
D000818:Animals; D001923:Brain Chemistry; D002784:Cholesterol / Q000032:analysis; D002788:Cholesterol Esters / Q000032:analysis*; D002849:Chromatography, Gas; D004660:Encephalitis / Q000209:etiology / Q000378:metabolism*; D005227:Fatty Acids / Q000032:analysis; D008297:Male; D008457:Measles / Q000150:complications / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000032:analysis*; D014018:Tissue Distribution
D002788:Cholesterol Esters; D005227:Fatty Acids; D002784:Cholesterol