title: Hematoporphyrin derivative and laser photoradiation in the diagnosis and treatment of bladder cancer.
abstract: Diagnosis and treatment of 8 patients with malignant bladder tumors were performed with intravenous administration of hematoporphyrin derivative, followed by krypton-ion laser violet light photoradiation and argon-dye laser red light photoradiation therapy. Fluorescence permitting localization and evaluation of the lesion was recognized in all 8 patients. Photoradiation with red argon-dye laser light obtained complete remission in 6 patients, with followup from 6 to 18 months. To our knowledge this is the first report describing total regression of bladder tumors obtained by photoradiation. Swelling and edema were noted within 20 minutes after argon-dye laser photoradiation therapy of bladder tumors. Necrosis and partial covering of the tumor by a whitish necrotic mass were noted after 3 days. The whitish mass covered the entire tumor at 7 to 14 days. Gradual exfoliation of the mass was followed by disappearance of the tumor and regeneration of normal mucosa at 9 to 10 weeks.
mesh_terms: D000328:Adult; D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis* / Q000628:therapy; D006415:Hematoporphyrins; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000628:therapy
chemical_list: D006415:Hematoporphyrins