Evidence that medium-chain fatty acid oxidation can support an active gluconeogenesis in the suckling newborn rat.
Long-chain fatty acid oxidation was inhibited in 1-day-old suckling rats by 2-tetradecylglycidic acid. Within 6 h it induced profound hypoketonemia and hypoglycemia together with a decreased rate of gluconeogenesis estimated from [U-14-C]-lactate incorporation into glucose. Medium-chain triglyceride feeding restored, within 3 h, normal blood concentrations of ketones and glucose as well as a high gluconeogenic rate from [U-14-C]-lactate. It is concluded that in the suckling newborn rat 2-tetradecylglycidic acid is effective in inhibiting selectively long-chain fatty acid oxidation and that medium-chain fatty acid oxidation can support an active gluconeogenesis.
D000818:Animals; D000833:Animals, Suckling; D001786:Blood Glucose / Q000032:analysis; D004852:Epoxy Compounds / Q000494:pharmacology*; D004988:Ethers, Cyclic / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism* / Q000494:pharmacology*; D005943:Gluconeogenesis / Q000187:drug effects*; D007657:Ketone Bodies / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000494:pharmacology*
D001786:Blood Glucose; D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D005227:Fatty Acids; D007657:Ketone Bodies; D014280:Triglycerides; C021756:2-tetradecylglycidic acid