title: Study of carcinogenic effects of in vitro argon laser exposure of fibroblasts.
abstract: Safety of laser exposure and tissue interaction and possible future carcinogenic effects of laser energy are investigated in this study. Mouse fibroblasts of the BALB/3T3 strain have now become the standard in science for the investigation of carcinogenic effects of a variety of physical and chemical/toxic agents. BALB/3T3 fibroblasts were grown in tissue culture and then exposed to x-ray irradiation and argon laser energy. The cells were then grown nine generations and scored for malignant type III foci in a randomized double-blind manner. Argon laser-treated cell groups were then compared with normal untreated controls and known carcinogenic x-ray controls. The results demonstrated that exposure of mouse fibroblasts in vitro tissue culture to argon laser energy did not produce a statistically significant transformation frequency as compared with that of known carcinogenic agents such as x-ray or untreated controls.
mesh_terms: D000818:Animals; D001128:Argon; D002471:Cell Transformation, Neoplastic; D004311:Double-Blind Method; D005347:Fibroblasts / Q000473:pathology / Q000528:radiation effects*; D066298:In Vitro Techniques; D007834:Lasers / Q000009:adverse effects*; D051379:Mice; D011897:Random Allocation
chemical_list: D001128:Argon