Combined treatment of autochthonous 3-methylcholanthrene-induced murine tumors by immunotherapy and radiotherapy.
C57BL/6J mice with autochthonous 3-methylcholanthrene-induced tumors were given combined therapy with 2,000 rad of local irradiation and regional injections of cell-wall skeleton of Nocardia rubra (N-CWS). The greatest suppression of the tumor growth and the highest survival rate were observed in the combined treatment group as compared to the non-treated control, regional injections of N-CWS alone and irradiation alone groups. In addition, pulmonary metastasis was significantly suppressed by the combined therapy.
D000818:Animals; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D005260:Female; D005354:Fibrosarcoma / Q000628:therapy; D007167:Immunotherapy; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary; D008748:Methylcholanthrene; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000628:therapy*; D009615:Nocardia / Q000276:immunology*
D001428:Bacterial Vaccines; D008748:Methylcholanthrene