In vivo survival of [14C]sucrose-loaded porcine carrier erythrocytes.
Porcine carrier erythrocyte survival was measured in adult pigs. [14C]Sucrose-loaded erythrocytes had a biphasic survival curve, with as much as 50% of the cells removed from circulation in the first 24 hours. The remaining cells had a 35-day half-life. Encapsulation values were measured for porcine erythrocytes and entrapment of [14C]sucrose was greater than 45%. Addition of inosine and glucose to the dialyzed cells and to the final wash buffer before reinjection of autologous cells did not improve their survival.
D000818:Animals; D002250:Carbon Radioisotopes; D004905:Erythrocyte Aging; D014677:Pharmaceutical Vehicles; D013395:Sucrose; D013552:Swine / Q000097:blood*
D002250:Carbon Radioisotopes; D014677:Pharmaceutical Vehicles; D013395:Sucrose