Improvement of skin flap survival by local injections of Regitine and propranolol. An experimental study in the rat.
An increase in the surviving area of skin flaps was achieved by local injections of alpha-adrenergic and beta-adrenergic blocking agents. Dorsal skin flaps of albino rats were injected postoperatively at their bases with Regitine (Ciba-Geigy, Switzerland), propranolol and a combination of these two drugs, two or three times daily for 6 days. All the pharmacologically treated animals showed a significantly better flap survival rate than did the control group (P less than 0.001). More frequent injections gave increasing flap survival areas. However, a combination of the above-mentioned drugs did not improve the results when compared with propranolol administered alone, and was less effective than Regitine administered alone.
D000818:Animals; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D010646:Phentolamine / Q000008:administration & dosage* / Q000494:pharmacology; D011433:Propranolol / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013524:Surgical Flaps
D004338:Drug Combinations; D011433:Propranolol; D010646:Phentolamine