Cimetidine and portal pressure in chronic liver disease.
Portal pressure was determined in 10 patients with chronic liver disease before and after an infusion of cimetidine. The drug had no significant effect on portal hypertension. Suggestions that histamine H2-receptor antagonists, by decreasing portal pressure, may be useful in the management of bleeding from esophageal varices are not supported by these results.
D002927:Cimetidine / Q000627:therapeutic use*; D006146:Guanidines / Q000627:therapeutic use*; D006503:Hepatic Veins / Q000187:drug effects; D006801:Humans; D006975:Hypertension, Portal / Q000188:drug therapy; D008107:Liver Diseases / Q000503:physiopathology*; D011169:Portal Vein / Q000187:drug effects*; D014690:Venous Pressure / Q000187:drug effects
D006146:Guanidines; D002927:Cimetidine