The effects of using different grades of PVP and gelatin as binders in the fluidized bed granulation and tabletting of lactose.
The effects of using different grades of PVP and gelatin binders on three sieve fractions of lactose granulated in a fluidized bed granulator and tablets have been studied. Increasing the molecular mass of PVP or bloom number of gelatin resulted in a decrease in granule friability but in an increase in their average size and porosity and in the tensile strengths of the resulting tablets when compressed to a fixed apparent density. The results have been explained in terms of the effects of moist and dry binder bridges on bonding of particles in granules and tablets.
D004339:Drug Compounding; D005079:Excipients; D005780:Gelatin; D007785:Lactose; D008970:Molecular Weight; D010316:Particle Size; D011205:Povidone; D011208:Powders; D013607:Tablets
D005079:Excipients; D011208:Powders; D013607:Tablets; D005780:Gelatin; D011205:Povidone; D007785:Lactose