Effect of amphotericin B on natural killer cell activity in vitro.
Incubation of murine peritoneal and spleen natural killer cells with amphotericin B at concentrations of 2.5, 5 and 10 mg/l in vitro, resulted in depression of their tumoricidal activity which had been augmented in vivo by infection with Toxoplasma gondii. In contrast, amphotericin B at the same concentrations had little or no effect on spontaneous natural killer cell activity in vitro. These in-vitro data suggest amphotericin B may have adverse effects on natural killer cell function in vivo.
D000666:Amphotericin B / Q000494:pharmacology*; D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000276:immunology; D014123:Toxoplasmosis / Q000276:immunology
D000666:Amphotericin B