title: Short segment Hirschsprung's disease as a cause of discrepancy between histologic, histochemical, and clinical features.
abstract: Diagnostic difficulty may be encountered in Hirschsprung's disease when discrepancy is noted between the histochemical pattern, the presence or absence of ganglion cells, and clinical features. This is mainly a problem in neonates, and the cause of the discrepancy is probably due to biopsy specimens being taken above a short aganglionic segment. When short segment Hirschsprung's disease is suspected, a low suction biopsy should be taken for the demonstration of acetylcholinesterase activity.
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D002675:Child, Preschool; D002799:Cholinergic Fibers / Q000473:pathology; D005260:Female; D006627:Hirschsprung Disease / Q000175:diagnosis* / Q000201:enzymology / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012007:Rectum / Q000201:enzymology / Q000294:innervation / Q000473:pathology
chemical_list: D000110:Acetylcholinesterase