[DNA synthesis in the liver of irradiated and serotonin-protected rats after removal of the cycloheximide block].
The cycloheximide block model was proposed to study the mechanism of action of both radiation and radioprotectors. It was shown that irradiation of proliferating hepatocytes in vivo, at early stages of the prereplicative phase, markedly inhibited DNA synthesis. Serotonin, in its turn, considerably increased DNA synthesis maintaining this increase after subsequent exposure to X-radiation.
D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D008297:Male; D011833:Radiation Injuries, Experimental / Q000378:metabolism* / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D012701:Serotonin / Q000627:therapeutic use*
D011837:Radiation-Protective Agents; D012701:Serotonin; D004247:DNA; D003513:Cycloheximide
Izuchenie sinteza DNK pri obluchenii i zashchite serotoninom v pecheni krys posle sniatiia tsiklogeksimidnogo bloka.