The regulatory properties of rabbit muscle pyruvate kinase. The influence of effector concentrations.
The initial velocity of the reaction catalysed by rabbit muscle pyruvate kinase was studied as a function of the concentrations of the modifiers phenylalanine and fructose 1,6-bisphosphate under conditions where the relationships between the initial velocities and the concentrations of substrates are non-hyperbolic. It is shown that these data can be represented by the exponential model for a regulatory enzyme.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D005635:Fructosediphosphates / Q000494:pharmacology*; D006598:Hexosediphosphates / Q000494:pharmacology*; D007700:Kinetics; D008954:Models, Biological; D009132:Muscles / Q000201:enzymology*; D010649:Phenylalanine / Q000494:pharmacology*; D011770:Pyruvate Kinase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011817:Rabbits
D005635:Fructosediphosphates; D006598:Hexosediphosphates; D010649:Phenylalanine; D000244:Adenosine Diphosphate; D011770:Pyruvate Kinase; C029063:fructose-1,6-diphosphate