Persisting selective block of unmyelinated fibers in cutaneous nerves of the cat by distilled water.
Experiments were done in vivo on the sural nerve of the cat's hindlimb. The nerve was desheathed for a length of 8 mm and superfused by Tyrode solution or distilled water. Electrical stimulation and recording was used to evaluate conduction block of nerve fibers. Irrigation with distilled water for periods of 3-5 min caused a persisting selective block of conduction in C-fibers while most of the A-fibers were unaffected. Recovery of the C-fibers never occurred during the time of observation (up to 130 min).
D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D006614:Hindlimb / Q000294:innervation*; D009412:Nerve Fibers / Q000187:drug effects*; D009413:Nerve Fibers, Myelinated / Q000187:drug effects; D009431:Neural Conduction / Q000187:drug effects*; D012867:Skin / Q000294:innervation*; D013497:Sural Nerve / Q000187:drug effects; D014867:Water / Q000494:pharmacology*
D014867:Water