Synthesis, acute toxicity and chemotherapeutic anti-cancer activities of a new tripeptidic mustard.
A new antitumor agent having the chemical composition of 3-(p-fluorophenyl)-Lalanyl-3-[m-bis-(2-chloroethyl)aminophenyl]-L- alanyl-L-methionine ethyl ester hydrochloride (PTT 119) was synthetized. It fundamental toxicological data in mice and rats were assessed; its antitumor activity was investigated by establishing in mice, inoculated with L 1210 leukemia or in AKR mice with spontaneous leukemia of viral origin, a significant increase in Mean Survival Time as well as a percent increase of Increased Life Span and of the number of survivors.
D000818:Animals; D000970:Antineoplastic Agents / Q000032:analysis / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007942:Leukemia, Experimental / Q000188:drug therapy; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009588:Nitrogen Mustard Compounds / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000970:Antineoplastic Agents; D009588:Nitrogen Mustard Compounds; C038259:ambamustine