A 195Hgm-195Aum generator for use in first-pass nuclear angiocardiography.
The development of a mercury-195m/gold-195m radionuclide generator system is described, together with the results of preliminary experiments in animals and in man. The daughter radionuclide has a half-life of 30.5 s with a principal gamma emission at 262 keV, ideal for use with the multicrystal camera but suitable also in conjunction with the Anger design. The half-life of the parent radionuclide is 40 h. The eluant in current use is 2.5 mM sodium cyanide, the column being stored under 2% sodium nitrate solution when not in use to prevent radiation damage. Generators capable of delivering 550 MBq of 195Aum in a 0.4 ml bolus have been used for first-pass nuclear angiocardiography, the half-life being long enough to permit administration via peripheral intravenous injection. The radiation dose associated with this radionuclide is much lower than that from conventional 99Tcm-labelled radiopharmaceuticals, permitting multiple sequential studies, even on children.
D000818:Animals; D003486:Cyanides / Q000097:blood; D004285:Dogs; D004912:Erythrocytes / Q000032:analysis; D006050:Gold Radioisotopes / Q000008:administration & dosage*; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007275:Injections, Intravenous; D008631:Mercury Radioisotopes; D011817:Rabbits; D011876:Radionuclide Generators; D011877:Radionuclide Imaging; D013552:Swine; D013861:Thiocyanates / Q000097:blood
D003486:Cyanides; D006050:Gold Radioisotopes; D008631:Mercury Radioisotopes; D013861:Thiocyanates