title: Rhinoscleroma--a diagnostic challenge.
abstract: Rhinoscleroma is a rare chronic granulomatous infection predominantly affecting the upper respiratory tract. The patient presented here exemplifies several features of the disease, including the fact that diagnosis may elude the clinician for years, and this delay may increase morbidity substantially. The most common initial complaint is nasal obstruction, and physical examination frequently reveals erythematous granular or nodular swellings covered with crusts. Its tumor-like appearance and local spread arouses suspicion of malignancy, but differential diagnosis also includes fungal infections and numerous granulomatous diseases. The classic histopathology consists of large vacuolated Mikuliz's cells and transformed plasma cells with Russell bodies. Numerous antibiotics have been used for treatment of this infection with varying degrees of success. Long-term follow-up is important because these patients can have numerous relapses. Geographic distribution is also discussed.
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008800:Mexico / Q000208:ethnology; D008875:Middle Aged; D010160:Palate, Soft / Q000473:pathology; D012226:Rhinoscleroma / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents