Reticulocytopenic, coombs' positive anemia induced by procainamide.
A case of Coombs' positive anemia in a man who had procainamide-induced lupus erythematosus syndrome is reported. The patient had a hemoglobin of 4.3 gm/dl and reticulocytopenia (3.1% corrected). Serum lactate dehydrogenase and haptoglobin levels were normal, and total bilirubin was only slightly elevated. Two other reported cases of procainamide-induced hemolytic anemia have demonstrated similar findings. Apparently, procainamide occasionally may induce a reversible, reticulocytopenic, Coombs' positive anemia that is not associated with laboratory evidence of acute hemolysis.
D000743:Anemia, Hemolytic / Q000139:chemically induced*; D003298:Coombs Test; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011342:Procainamide / Q000009:adverse effects*; D012156:Reticulocytes / Q000187:drug effects
D011342:Procainamide