title: Incidence of chromosomal aberrations in patients under combined tuberculostatic chemotherapy.
abstract: Chromosome studies were carried out on the peripheral blood lymphocytes of ten tuberculosis (tb) patients receiving combined tuberculostatic chemotherapy for long intervals (3-10 months) and on those of two control groups, one of ten healthy subjects and the second of ten other tb patients in whom the tuberculostatic treatment had been discontinued 10-19 months previously. An increased proportion of aberrations, particularly chromosomal breaks and achromatic gaps, were observed in the patients under treatment, suggesting a possible synergic interaction of INH and RMA in the production of chromosomal damage.
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D002869:Chromosome Aberrations; D004359:Drug Therapy, Combination; D004977:Ethambutol / Q000009:adverse effects*; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology; D008677:Metaphase; D012293:Rifampin / Q000009:adverse effects*; D013307:Streptomycin / Q000009:adverse effects*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin