Caffeine metabolism and coffee-attributed sleep disturbances.
In six healthy subjects with a history of caffeine-induced wakefulness caffeine kinetics were compared to with those in six subjects not affected by caffeine. The data indicated that the former have a longer plasma t 1/2 (mean 7.4 and 4.2 hr) and slower plasma clearance (mean 1.2 and 1.7 ml . min-1 . kg-1) of caffeine. Plasma caffeine concentration at midnight, 8 hr after afternoon coffee, is higher in those with caffeine-attributed insomnia. Those reporting "coffee wakefulness" also tend to drink less coffee. We conclude that the rate of caffeine metabolism is a determinant of individual variation in the effect of drinking coffee on sleep.
D000328:Adult; D002110:Caffeine / Q000009:adverse effects / Q000378:metabolism*; D003069:Coffee; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced*; D013997:Time Factors
D003069:Coffee; D002110:Caffeine