Aminoadipic acid toxic effects on retinal glial cells.
The toxic effects of DL-alpha-aminoadipic acid on retinal glial cells were examined histologically following intravitreal injection to rats or rabbits. There was a marked swelling Müller cells, astrocytes and oligodendrocytes, but no changes in the microglia. Injections of a low concentration of the solution (0.1 mg in 0.01 ml) produced no irreversible damage to the Müller cells. With high concentrations (1 mg in 0.01 ml), there was a necrosis of Müller cells followed by thinning of the retina and disruption of the outer limiting membrane,
D015074:2-Aminoadipic Acid / Q000008:administration & dosage / Q000633:toxicity*; D000600:Amino Acids, Dicarboxylic / Q000633:toxicity*; D000818:Animals; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D013997:Time Factors; D014822:Vitreous Body
D000600:Amino Acids, Dicarboxylic; D015074:2-Aminoadipic Acid