title: [External corticoid therapy: continuous versus discontinuous use].
abstract: Taking into account the factors of local bioavailability, the phenomenon of tachyphylaxis and biorhythm as well as the skin and the internal production of cortisone, side effects can be reduced by the intermittent use of topical corticoid preparations and reduced dosage. Atopic dermatitis is taken as an example to explain some corticoid-saving measures during long-term treatment.
mesh_terms: D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D001682:Biological Availability; D002940:Circadian Rhythm / Q000187:drug effects; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004485:Eczema / Q000188:drug therapy; D006801:Humans; D006854:Hydrocortisone / Q000097:blood
chemical_list: D000305:Adrenal Cortex Hormones; D006854:Hydrocortisone
vernacular_title: Externe Kortikoidtherapie: Kontinuierliche versus diskontinuierliche Anwendung.