Biphasic hypotensive effects of 5-methylfurmethide on the mean arterial blood pressure of rats.
The effects of 5-methylfurfuryltrimethylammonium iodide (5-methylfurmethide) on the mean arterial blood pressure of male Sprague-Dawley rats were investigated. The agent elicited a linear biphasic but non-parallel fall in the mean arterial blood pressure. The hypotensive effects were blocked by pretreatment of the animals with atropine suggesting the possible involvement of muscarinic receptors in the effects.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D009116:Muscarine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D002800:Cholinesterase Inhibitors; C008446:5-methylfurtrethonium; D001285:Atropine; D009116:Muscarine; D010424:Pentobarbital