[The risk of hemorrhaging in the prevention of thromboembolism in general surgery: comparison of low-dose heparin and heparin-dihydergot 2500].
In a prospective randomized double-blind study, the risk of heparin-induced intra- or postoperative hemorrhage in prophylaxis of thromboembolism was studied. 500 general surgical patients were divided into 2 groups; group A receiving a reduced portion of heparin (2 X 2500 IU) in combination with 0.5 mg dihydroergotamine (DHE) was compared to group B with conventional low dose heparin regimen (2 X 5000 IU) with regard to postoperative wound hematomas and reoperation for hematoma. After prophylaxis with heparin dihydroergotamine 2500 wound hematoma and reoperation for hematoma are shown to be reduced in a significant way (p = 0.03).
D000328:Adult; D000368:Aged; D004087:Dihydroergotamine / Q000008:administration & dosage*; D004311:Double-Blind Method; D004338:Drug Combinations / Q000008:administration & dosage; D005260:Female; D006470:Hemorrhage / Q000517:prevention & control*; D006493:Heparin / Q000008:administration & dosage*; D006495:Heparin, Low-Molecular-Weight; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D011446:Prospective Studies; D011897:Random Allocation; D012306:Risk; D013514:Surgical Procedures, Operative; D013923:Thromboembolism / Q000517:prevention & control*
D004338:Drug Combinations; D006495:Heparin, Low-Molecular-Weight; C031388:heparin-dihydergot; D004087:Dihydroergotamine; D006493:Heparin
Das Blutungsrisiko der Thromboembolie-Prophylaxe in der Allgemeinchirurgie: Vergleich von low-dose-Heparin mit Heparin-Dihydergot 2500.