[3H]Mesulergine, a selective ligand for serotonin-2 receptors.
[3H]Mesulergine binds with high affinity to rat cerebral cortex membranes. (KD = 1.9 nM, Bmax = 11.3 pM/g tissue). The binding of this ligand is selective for serotonin-2 receptors: Its next highest affinity, which is for dopamine receptors labelled by neuroleptics, is about 50 times weaker than its affinity for serotonin-2 receptors. No significant affinity for serotonin-1, alpha 1-adrenergic or histamine H1 receptors was observed. Specific [3H]mesulergine binding was diminished in the presence of low concentrations of lithium ions.
D000818:Animals; D002412:Cations; D002540:Cerebral Cortex / Q000378:metabolism*; D004873:Ergolines / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007700:Kinetics; D008094:Lithium / Q000494:pharmacology; D008297:Male; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism*; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology
D002412:Cations; D004873:Ergolines; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D012701:Serotonin; D008094:Lithium; C031649:mesulergine