One day versus seven days of preventive antibiotic therapy in orthopedic surgery.
Three hundred fifty-eight patients undergoing total hip arthroplasty, total knee arthroplasty, and hip fracture repair were given preventive antibiotics 20 minutes before surgery; administration of antibiotics was continued for either 24 hours or seven days. The 24-hour group (186 operations) had three (1.6%) deep wound infections. The difference in infection rates between groups was not significant.
D000328:Adult; D000368:Aged; D002437:Cefazolin / Q000008:administration & dosage*; D006620:Hip Fractures / Q000601:surgery; D006622:Hip Prosthesis; D006801:Humans; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D009254:Nafcillin / Q000008:administration & dosage*; D011292:Premedication; D013530:Surgical Wound Infection / Q000517:prevention & control*
D009254:Nafcillin; D002437:Cefazolin