title: A case of IgA nephropathy with an unusual response to corticosteroid and immunosuppressive therapy.
abstract: We report a case of IgA nephropathy that presented with nephrotic syndrome without hematuria. Renal biopsy revealed typical features of IgA nephropathy on light microscopy, immunofluorescence microscopy, and electron microscopy. A dramatic response occurred on corticosteroid and immunosuppressive therapy, characterized by clearance of proteinuria and a fall of serum IgA level to normal. The absence of hematuria and a response to therapy are distinctly unusual features of IgA nephropathy. This case represents a variant of IgA nephropathy associated with a nephrotic syndrome that resembles nephrotic syndrome with minimal change lesion in its responsiveness to immunosuppressive therapy.
mesh_terms: D000328:Adult; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005921:Glomerulonephritis / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D008297:Male; D009404:Nephrotic Syndrome / Q000209:etiology; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D007070:Immunoglobulin A; D003520:Cyclophosphamide; D011241:Prednisone