Electrophoretic variation for X chromosome-linked hypoxanthine phosphoribosyl transferase (HPRT) in wild-derived mice.
An electrophoretic variation for hypoxanthine phosphoribosyltransferase, HPRT, has been identified in samples of Mus spretus, a field mouse from southern Europe and in M. m. castaneus, a house mouse from southeast Asia. These mice will interbreed with laboratory mice to produce viable, fertile F1 progeny. The variation for HPRT segregates as an X chromosome gene in F1 and backcross progeny. Linkage analysis involving the markers Pgk-1 and Ags indicated a gene order of centromere--Hprt--Pgk-1--Ags in crosses involving both stocks of wild mice.
D000818:Animals; D003433:Crosses, Genetic; D004592:Electrophoresis, Starch Gel; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D014644:Genetic Variation; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics*; D008297:Male; D051379:Mice; D009115:Muridae / Q000235:genetics*; D012730:Sex Chromosomes; D013045:Species Specificity; D014960:X Chromosome
D007041:Hypoxanthine Phosphoribosyltransferase