Tandem translocation t(14;14) in isolated and clonal cells in ataxia telangiectasia are different.
In a patient affected by ataxia telangiectasia (AT), an invading clone with a t(14;14) was found in PHA-, but not in pokeweed-stimulated, lymphocytes. With high resolution R-banding, the proximal breakage was visualized at the junction of bands q11.1-q11.2. This breakpoint differs from that (q12) of noninvading rearrangements of chromosome 14 in AT and non-AT patients. These differences are discussed.
D001260:Ataxia Telangiectasia / Q000235:genetics*; D002648:Child; D002871:Chromosome Banding; D002901:Chromosomes, Human, 13-15; D002999:Clone Cells; D006801:Humans; D008297:Male; D008938:Mitosis; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D014178:Translocation, Genetic
D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens