title: [Dysmyelopoietic syndrome 7 years after melphalan treatment of multiple myeloma. Clinical case].
abstract: A case of myelodysplasia (refractory anaemia with excessive blasts) arising 7 years after a 3 year period of intermittent monthly treatment cycles with melphalan for multiple myelomas is reported. This is another example of preleukaemic syndrome possibly caused by melphalan. Among the possible pathogenetic mechanisms, the incidence of cyclic episodes of medullary hypoplasia are emphasised.
mesh_terms: D001803:Blood Transfusion; D017707:Erythrocyte Transfusion; D005260:Female; D006801:Humans; D008558:Melphalan / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy*; D009196:Myeloproliferative Disorders / Q000139:chemically induced* / Q000628:therapy; D017713:Platelet Transfusion; D011241:Prednisone / Q000627:therapeutic use; D011289:Preleukemia / Q000628:therapy; D013997:Time Factors
chemical_list: D008558:Melphalan; D011241:Prednisone
vernacular_title: Sindrome dismielopoietica sette anni dopo trattamento di mieloma multiplo con melphalan. Caso clinico.