Evidence for inhibition of monoamine oxidase in vivo in rat brain by 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (DCTQ) (50 mg/kg i.p.) antagonized the inactivation of MAO by pargyline as measured by direct enzyme assays in brain homogenates and by accumulation of hypothalamic catecholamines. These findings lend credence to the earlier interpretation that changes in brain concentrations of biogenic amines and their metabolites in DCTQ-treated rats were due at least in part to MAO inhibition.
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D001921:Brain / Q000201:enzymology*; D002395:Catecholamines / Q000378:metabolism; D006246:Harmaline / Q000494:pharmacology; D007031:Hypothalamus / Q000378:metabolism; D007546:Isoquinolines / Q000494:pharmacology*; D008996:Monoamine Oxidase Inhibitors; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D044005:Tetrahydroisoquinolines
D001679:Biogenic Amines; D002395:Catecholamines; D007546:Isoquinolines; D008996:Monoamine Oxidase Inhibitors; D044005:Tetrahydroisoquinolines; D010293:Pargyline; C012153:7,8-dichloro-1,2,3,4-tetrahydroisoquinoline; D006246:Harmaline