[Prospective study on the effect of various preparations of 1% mepivacaine solutions without preservatives].
On 30 volunteers the pain sensitivity and macroscopic changes at the area of intracutaneous injection of 1% mepivacain solutions without adrenalin (and a sodium chloride reference solution) were investigated. It was found that the injection of solutions with only sodium chloride as ingredient were relatively pain sensitive, whereas the injection of preparations which contained also calcium chloride or this alone were much more comfortable. Clinically relevant side effects at the site of injection were not seen for any of the used solutions.
D000328:Adult; D000779:Anesthetics, Local; D002122:Calcium Chloride / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008619:Mepivacaine / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology; D012684:Sensory Thresholds / Q000187:drug effects*; D012965:Sodium Chloride / Q000494:pharmacology
D000779:Anesthetics, Local; D012965:Sodium Chloride; D008619:Mepivacaine; D002122:Calcium Chloride
Prospektive Studie über den Einfluss verschiedener Zubereitungen von 1%igen Mepivacainlösungen ohne Konservierungsmittel.