Time course of pimozide effects on brain stimulation reward.
Lever pressing for brain stimulation reward (BSR) was tested at hourly intervals following 0.5 or 1.0 mg/kg of pimozide given intraperitoneally. Response suppression was seen within one or two hours and peak effects occurred 5-8 hours after injection. Recovery approached completion within about 24 hours. Since peak brain levels of pimozide are reached quickly, the time course of peak action suggests a complex mechanism of pimozide action.
D000818:Animals; D001921:Brain / Q000502:physiology*; D003216:Conditioning, Operant / Q000187:drug effects; D004558:Electric Stimulation; D008297:Male; D010868:Pimozide / Q000494:pharmacology*; D051381:Rats; D012201:Reward
D010868:Pimozide