Recognition of marrow elements by natural killer cells: are NK cells involved in haemopoietic regulation?
NK cells from young normal mice are cytolytic in vitro for a virus-induced tumour cell line, YAC-1. Cytotoxicity is inhibited by the addition of unlabelled homologous YAC-1 cells and by regenerating bone marrow cells from the spleens of lethally irradiated, bone-marrow-grafted mice. Quiescent marrow from syngeneic and allogeneic mice produces little or no competition. This suggests that NK cells recognize, and may regulate, marrow progenitor cells.
D000818:Animals; D001853:Bone Marrow / Q000276:immunology*; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D005260:Female; D006410:Hematopoiesis; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000276:immunology