Conformational study of two polymorphs of spiperone: possible consequences on the interpretation of pharmacological activity.
A second polymorph of spiperone, 8-[3-(p-fluorobenzoyl)-propyl]-1-phenyl-1,3,8-triazaspiro[4,5] decan-4-one, has been isolated and characterized by thermal analysis and IR spectrometry. Its structure was solved by X-ray diffraction analysis. The results are compared with those previously obtained on spiperone, the main difference being in the conformation of the side chain and in the nature of the hydrogen bonding.
D002090:Butyrophenones / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D013055:Spectrophotometry, Infrared; D013134:Spiperone / Q000494:pharmacology; D013696:Temperature; D013816:Thermodynamics; D014961:X-Ray Diffraction
D002090:Butyrophenones; D013134:Spiperone