Developmental changes of glial fibrillary acidic protein in cerebral white matter.
Developmental changes were observed in the glial fibrillary acidic protein (GFAP)--positive glia of cerebral white matter (including myelination glia) in the frontal lobes of 38 normal cases. With age, GFAP-positive processes gradually became larger and their location shifted from preponderantly in the deep white matter to mostly in the superficial white matter. This shift in pattern of GFAP-positive glia may be related to the parallel changes in perinatal brains in the localization of leukomalacic lesions. However, the shift is a normal developmental phenomenon on which such lesions are superimposed.
D000375:Aging; D002648:Child; D002675:Child, Preschool; D005625:Frontal Lobe / Q000032:analysis* / Q000166:cytology / Q000502:physiology; D005904:Glial Fibrillary Acidic Protein; D006801:Humans; D007223:Infant; D007381:Intermediate Filament Proteins / Q000032:analysis* / Q000502:physiology; D009186:Myelin Sheath / Q000166:cytology / Q000502:physiology; D009457:Neuroglia / Q000032:analysis* / Q000166:cytology / Q000502:physiology
D005904:Glial Fibrillary Acidic Protein; D007381:Intermediate Filament Proteins