title: Relationship between intraosseous pressures and intra-articular pressure in arthritis of the knee. An experimental study in immature dogs.
abstract: The influence of chronic synovial inflammation and effusion on the juxta-articular bone haemodynamics in the juvenile knee was studied in 12 immature dogs with Carragheenin-induced unilateral arthritis. Using a fluid filled electromanometric pressure recording system simultaneous pressure measurements were taken from the distal femoral metaphysis, juxta-articular epiphyses and knee joint cavity in general anaesthesia followed by intraosseous phlebographies. During resting conditions the intraosseous pressure of the distal femoral epiphysis and the intra-articular pressure was significantly elevated. The phlebographies showed increased accumulation of contrast in arthritic femoral epiphyses with decreased contrast clearance rate. During increasing intra-articular pressure an augmented vulnerability of the blood supply of the arthritic femoral epiphyses was demonstrated. The results suggests that joint effusion may play an important role in the bone changes in juvenile degenerative arthritis of the knee.
mesh_terms: D000818:Animals; D001168:Arthritis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001794:Blood Pressure; D002496:Central Venous Pressure; D004285:Dogs; D004838:Epiphyses / Q000098:blood supply; D005269:Femur / Q000098:blood supply*; D007719:Knee Joint / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000503:physiopathology; D010690:Phlebography