title: 1-(Aminomethyl)-6,7-dihydroxytetralin derivatives: synthesis and assessment of dopamine-like effects.
abstract: The title compounds were designed as flexible congeners of trans-octahydrobenz[h]isoquinoline, in which the dopamine moiety can exist in the alpha conformation. Extremely low dopamine-like effects in the title series in the cat cardioaccelerator nerve assay paralleled low activity in the trans-octahydrobenz[h]isoquinoline compounds and was consistent with a prior proposal of the presence of a bulky region on the dopamine receptor(s).
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D004298:Dopamine / Q000494:pharmacology*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D009281:Naphthalenes / Q000138:chemical synthesis*; D011433:Propranolol / Q000494:pharmacology; D011954:Receptors, Dopamine / Q000187:drug effects; D013268:Stimulation, Chemical; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D009281:Naphthalenes; D011954:Receptors, Dopamine; D013764:Tetrahydronaphthalenes; D011433:Propranolol; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine