Plasma bupivacaine concentrations in children during caudal epidural analgesia.
Plasma bupivacaine concentrations were measured in 45 children, whose ages ranged from 4 months to 12 years, following administration of caudal epidural analgesia. Using 3 mg/kg of bupivacaine 0.25%, mean blood levels of 1.2-1.4 microgram/ml were reached, which are well within the limits of projected toxic levels. Simultaneous arterial and venous sampling showed a small but significant difference between these two sampling sites fo the first fifteen minutes.
D000367:Age Factors; D000763:Anesthesia, Caudal; D001158:Arteries; D002045:Bupivacaine / Q000008:administration & dosage / Q000097:blood* / Q000633:toxicity; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007267:Injections; D012447:Sacrum; D013997:Time Factors; D014680:Veins
D002045:Bupivacaine