Inhibition of tumor promotion by a biomimetic superoxide dismutase.
A low molecular weight, lipophilic, copper coordination complex with superoxide dismutase-mimetic activity inhibited biochemical and biological actions of a tumor promoter in mouse epidermis. Such inhibitory effects implicate reactive oxygen species in the tumor promotion process.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002273:Carcinogens / Q000494:pharmacology; D005260:Female; D051379:Mice; D009955:Ornithine Decarboxylase / Q000378:metabolism; D010212:Papilloma / Q000139:chemically induced; D012459:Salicylates / Q000494:pharmacology; D012878:Skin Neoplasms / Q000139:chemically induced; D013482:Superoxide Dismutase / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D000970:Antineoplastic Agents; D002273:Carcinogens; D012459:Salicylates; C030865:copper bis(3,5-diisopropylsalicylate); D013482:Superoxide Dismutase; D009955:Ornithine Decarboxylase; D013755:Tetradecanoylphorbol Acetate