title: [Effect of the proteolytic enzyme papain on the body organs and systems of experimental animals].
abstract: When administered intravenously and intraarterially papaine (2.5 and 10 mg/kg) produces no toxic effects on respiration, arterial pressure, brain and intracranial circulation. Intrapleural, intraperitoneal and interstitial administration of papaine solutions in doses under 4.5 mg/kg produces no local or general changes on the part of experimental animals' organism.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D002536:Cerebral Arteries / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010206:Papain / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D012137:Respiratory System / Q000187:drug effects*; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D010206:Papain
vernacular_title: Vliianie proteoliticheskogo fermenta papaina na nekotorye organy i sistemy organizma éksperimental'nykh zhivotnykh.