title: Achalasia of the cardia associated with pulmonary sarcoidosis.
abstract: The case of a patient with sarcoidosis and symptoms suggestive of achalasia cardia is presented. Because of increasingly severe dysphagia, cardiomyotomy was performed and biopsy specimens of the esophageal wall were obtained. Light and electron microscopy revealed lesions of the nerves in Auerbach's plexus consisting of an inflammatory process and demyelinization of the nerve fibers. Since the operation, the patient has been swallowing without difficulty. Although previous reports have described dysphagia in patients with sarcoidosis, presumably secondary to mechanical compression by adjacent lymph nodes or infiltration of the esophageal wall by sarcoid granulomata, this report documents for the first time that dysphagia can also be caused by direct involvement of the innervation of the esophagus by sarcoidosis.
mesh_terms: D003680:Deglutition Disorders / Q000209:etiology; D003711:Demyelinating Diseases / Q000473:pathology; D004931:Esophageal Achalasia / Q000209:etiology*; D004947:Esophagus / Q000294:innervation / Q000473:pathology; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000150:complications*; D008875:Middle Aged; D012507:Sarcoidosis / Q000150:complications*