Infection of mouse teratocarcinoma stem cells with influenza virus: normal expression of proteins derived from spliced messenger RNAs.
Mouse teratocarcinoma stem cells before and after induction of differentiation have been infected with influenza virus. This virus is able to infect the cells irrespective of the state of differentiation. In addition, viral-encoded proteins that are known to be translated from spliced messenger RNAs are produced in normal amounts in the infected cells, and this expression is also independent of differentiation. These results indicate that both the stem cells and their differentiated progeny can efficiently splice the precursor RNAs for these influenza virus messengers.
D000818:Animals; D002460:Cell Line; D002472:Cell Transformation, Viral; D004591:Electrophoresis, Polyacrylamide Gel; D005786:Gene Expression Regulation; D009980:Influenza A virus; D051379:Mice; D012326:RNA Splicing; D013724:Teratoma / Q000382:microbiology*; D014764:Viral Proteins / Q000032:analysis*
D014764:Viral Proteins