title: Synergism of endogenous inhibitors, exogenous cytostatic agents and hormones in arrest of proliferation.
abstract: The synergism between endogenous regulators of proliferation (protors), alkylating agents and hormones in vitro was studied. The effects were monitored by the incorporation of 3H-TdR into human and rat short term bone marrow cultures and by the formation of mouse granulocyte-macrophage colonies in semisolid agar capillaries. An additive and/or slight potentiating synergism was demonstrated between different types of inhibitory protors (GI-3S2, GI-3S3 and GI-3B), between GI-3 and hydrocortisone, and between GI-3 and the alkylating agents (adriamycin, dianhydrogalactitol) examined. The results offer a real possibility of strengthening the inhibition of neoplastic proliferation without increasing cytotoxicity of the drugs used.
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D002417:Cattle; D002455:Cell Division / Q000187:drug effects*; D003961:Dianhydrogalactitol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000494:pharmacology; D004357:Drug Synergism; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D051381:Rats
chemical_list: D003961:Dianhydrogalactitol; D004317:Doxorubicin; D006854:Hydrocortisone