Non-metabolizable amino acids are potent stimulators of hepatic and renal ornithine decarboxylase activity.
The non-metabolizable amino acids alpha-aminoisobutyric acid (AIB) and cycloleucine and the poorly metabolizable amino acid D-alanine potently stimulated hepatic ornithine decarboxylase (ODC) activity in starved rats. The stimulation by AIB was shown to have several of the characteristics of stimulation by a protein meal and occurred in hypophysectomized animals. AIB also stimulated renal, but not brain or heart, ODC activity.
D000409:Alanine / Q000494:pharmacology; D000596:Amino Acids / Q000494:pharmacology*; D000621:Aminoisobutyric Acids / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000201:enzymology; D002262:Carboxy-Lyases / Q000378:metabolism*; D003515:Cycloleucine / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D009206:Myocardium / Q000201:enzymology; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D000621:Aminoisobutyric Acids; D003515:Cycloleucine; C100049:2-aminoisobutyric acid; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase; D000409:Alanine