An oncogenic cell line inducing transplantable metastasizing adeno-carcinomas in Xenopus borealis.
Three epithelioid cell lines were initiated from stage 35 tadpoles of Xenopus borealis. Cell strain XB693-M1 was obtained by incubation of one of these cell lines in MNNG. The strain is hypotetraploid with a modal chromosome number of 62. It is tumorigenic when 4 X 10(6) cells are injected into hosts belonging to a partially histocompatible family. The tumors are very invasive, metastasizing adenocarcinomas that kill the host within 5 to 38 weeks. The tumor can be propagated in vivo by serial transplantation.
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology*; D000818:Animals; D002460:Cell Line; D008769:Methylnitronitrosoguanidine; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D014981:Xenopus
D008769:Methylnitronitrosoguanidine