Combination chemotherapy in retroperitoneal poorly differentiated myxoid liposarcoma: a report of a case.
We describe a case of a 47-year-old man with retroperitoneal poorly differentiated myxoid liposarcoma. The retroperitoneal invasion of the sarcoma caused hydroureter-nephrosis, rectal stenosis and also exaggerated steroid induced diabetes mellitus. A remarkable regression was achieved by systemic combination of chemotherapy with prednisolone, cyclophosphamide, vincristine sulfate and actinomycin D. This combination chemotherapy is worth trying if a patient has inoperable liposarcoma. It can also be used to reduce local recurrence rate after surgical or radiation therapy, or both, against liposarcoma.
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D003251:Constriction, Pathologic; D003520:Cyclophosphamide / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D003920:Diabetes Mellitus / Q000209:etiology; D004359:Drug Therapy, Combination; D006801:Humans; D008080:Liposarcoma / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009401:Nephrosis / Q000209:etiology; D011239:Prednisolone / Q000008:administration & dosage; D012002:Rectal Diseases / Q000209:etiology; D012186:Retroperitoneal Neoplasms / Q000150:complications / Q000188:drug therapy*; D014750:Vincristine / Q000008:administration & dosage
D000970:Antineoplastic Agents; D003609:Dactinomycin; D014750:Vincristine; D003520:Cyclophosphamide; D011239:Prednisolone