SCE, X-radiation sensitivity and mutation rate in multiple sclerosis.
In order to detect any underlying DNA abnormality that may be present in multiple sclerosis (MS), the incidence of SCE, X-radiation sensitivity and the frequency of 6-thioguanine-resistant cells were determined in the lymphocytes of 34 MS patients. As a group, MS patients showed an increase in the SCE rate compared to control. However, there was no increase in X-radiation sensitivity. The frequency of 6-thioguanine-resistant mutant cells was also normal.
D003434:Crossing Over, Genetic / Q000528:radiation effects*; D004351:Drug Resistance; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D009103:Multiple Sclerosis / Q000235:genetics*; D009154:Mutation; D012854:Sister Chromatid Exchange / Q000528:radiation effects*; D013866:Thioguanine / Q000494:pharmacology; D014965:X-Rays
D013866:Thioguanine