title: Improvements in the phosphoramidite procedure for the synthesis of oligodeoxyribonucleotides.
abstract: The paper describes an improved method for the synthesis of oligodeoxyribonucleotides using phosphoramidite chemistry. Our procedure relies on novel phosphoramidite intermediates, the deoxyribonucleoside-3'-morpholine-methoxyphosphins. These compounds are extremely stable and can be purified readily. Condensation reactions during solid-phase synthesis can thus be performed with high efficiency and result in a high yield synthesis of long chain oligodeoxyribonucleotides.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D008970:Molecular Weight; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D009841:Oligonucleotides / Q000138:chemical synthesis*; D010720:Phosphines
chemical_list: D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D010720:Phosphines