Effect of orally administered polysaccharide from kefir grain on delayed-type hypersensitivity and tumor growth in mice.
The effect of oral administration of a polysaccharide (KGF-C), isolated from the kefir grain, on delayed-type hypersensitivity (DTH) induced by picryl chloride and on the growth of solid tumor was examined in mice. KGF-C caused an increase in DTH response in intact mice and also tumor-bearing mice. The growth of tumor inoculated after the DTH test was markedly inhibited in the groups with high DTH response. A significant correlation between the DTH response and the antitumor activity was observed in intact mice.
D000284:Administration, Oral; D000818:Animals; D003611:Dairy Products; D006968:Hypersensitivity, Delayed; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000276:immunology; D011134:Polysaccharides / Q000494:pharmacology*
D011134:Polysaccharides