Efficacy of praziquantel against ovine cysticercosis caused by Taenia hydatigena.
Praziquantel was evaluated for its larvicidal activity against naturally or experimentally induced Taenia hydatigena infections in sheep. The major criterion used for assessing efficacy was an estimate of the dose rate required to free 90 per cent of the sheep from infection (ED90) together with a 95 per cent confidence interval. With both light and heavy infections of three-month-old T hydatigena in lambs up to 12 months old, many larvae were killed. The ED90 and 95 per cent confidence limits for six-month-old and aged organisms was estimated to be 13.1 (5.5 to 31.4) mg/kg and 6.1 (2.4 to 15.5) mg/kg, respectively. Equivalent data for the ED50 were 3.4 (1.4 to 8.3) mg/kg and 1.3 (0.3 to 5.4) mg/kg, respectively. It was established that one of the factors involved in the efficacy of praziquantel was associated with the age of the larvae at the time of treatment, the drug being markedly more effective against older than younger organisms.
D000367:Age Factors; D000818:Animals; D003551:Cysticercosis / Q000188:drug therapy / Q000662:veterinary*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007546:Isoquinolines / Q000008:administration & dosage*; D011223:Praziquantel / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*; D013621:Taenia / Q000187:drug effects; D013622:Taeniasis / Q000188:drug therapy / Q000662:veterinary*
D007546:Isoquinolines; D011223:Praziquantel