Interaction of foetal and adult human acetylcholine receptors with serum from patients with myasthenia gravis.
Acetylcholine receptors were partially purified from foetal and adult human muscle and their binding to myasthenic serum was compared. No significant differences between the binding characteristics of the two receptor types were detected; indicating the absence, at least in 14-22-week-old foetuses of antigenic sites unique to foetal receptor and recognised by myasthenic sera.
D000328:Adult; D000906:Antibodies / Q000276:immunology; D005333:Fetus / Q000276:immunology*; D005865:Gestational Age; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D009132:Muscles / Q000276:immunology; D009157:Myasthenia Gravis / Q000097:blood / Q000276:immunology* / Q000503:physiopathology; D011950:Receptors, Cholinergic / Q000276:immunology* / Q000502:physiology
D000906:Antibodies; D007074:Immunoglobulin G; D011950:Receptors, Cholinergic