[Anti-inflammatory activity of immunostimulants and their combinations with antiphlogistics].
A study was made of anti-inflammatory action of prodigiozan, levamisole and methyluracil and their combinations with butadion, brufen and prednisolone. Prodigiozan was more active than levamisole and methyluracil, while levamisole appeared to be more active than methyluracil. Prodigiozan was effective when given both in a single dose and repeated doses. The immunostimulants did not reduce the efficacy of butadion, brufen and prednisolone, and in some cases they made the drug action more powerful. After administration of metopyrone the action of prodigiozan was more potent. Prednisolone reduced the anti-inflammatory effect of prodigiozan.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004487:Edema / Q000188:drug therapy; D005260:Female; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D051379:Mice; D051381:Rats
D000276:Adjuvants, Immunologic; D000893:Anti-Inflammatory Agents
Protivovospalitel'naia aktivnost' nekotorykh immunostimuliatorov i ikh sochetaniĭ s antiflogistikami.