[Cholelithiasis--cholecystectomy and colonic cancer].
(1) In 24,089 autopsy records from 1956 to 1979 we found in 16,653 corpses without gallstones 495 = 2.97%, and in 7,436 corpses with gallstones 266 = 3.57% colorectal cancers.--(2) In 503 corpses with previous cholecystectomy performed more than one year before death we found 17 = 3.38% colorectal cancers.--(3) There is no higher incidence of colorectal cancer after cholecystectomy.--(4) In the corpses with gallstones, cholecystectomy or cirrhosis of the gallbladder there were significantly more cancers in the right hemicolon than in corpses without gallstones.--(5) A synetiology by genetic, epidemiologic or (and) metabolic factors may be possible.--(6) A Co-influence of primary bile acids on the genesis of colorectal cancer is discussed.--(7) In patients over 50 years with gallstones it is mandatory for the surgeon to exclude a co-existing colorectal cancer before performing cholecystectomy.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001647:Bile Acids and Salts / Q000378:metabolism; D002763:Cholecystectomy / Q000009:adverse effects*; D002769:Cholelithiasis / Q000150:complications*; D003110:Colonic Neoplasms / Q000209:etiology*; D004041:Dietary Fats / Q000009:adverse effects; D005260:Female; D005705:Gallbladder Diseases / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged
D001647:Bile Acids and Salts; D004041:Dietary Fats
Cholelithiasis--Cholezystektomie und Kolonkarzinom.