title: The in vitro selective concentration of an 125I-iodinated compound in human tumor cells.
abstract: Uptake studies of the potential endoradiotherapeutic agent, 6-125I-iodo-2-methyl-1,4-naphthoquinol bis(diammonium phosphate) have been carried out in vitro on a wide range of normal and malignant human cells. In general, for a standardized dose of 0.1 microCi/ml, the uptake of the compound into normal cells was 0.0015-0.135 pCi/cell. Uptake into malignant cells was significantly higher than normal cells; uptakes of 0.89-11.3 pCi/cell were noted for melanoma, teratoma of testis, osteosarcoma and adenocarcinoma of colon and pancreas. Comparative uptake ratios for melanoma: Chang liver cells and testicular teratoma:normal testis were 29 23, respectively. Larger uptake ratios are usually observed with higher doses.
mesh_terms: D000042:Absorption; D002460:Cell Line; D002478:Cells, Cultured; D005260:Female; D006207:Half-Life; D006801:Humans; D007457:Iodine Radioisotopes / Q000378:metabolism*; D008297:Male; D009284:Naphthols / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000378:metabolism; D010100:Oxygen / Q000502:physiology
chemical_list: D007457:Iodine Radioisotopes; D009284:Naphthols; C034178:6-iodo-2-methyl-1,4-naphthoquinol bis(diammonium phosphate); D010100:Oxygen