[Glucose-induced hyperlactatemias in thiamine deficiency].
Parenteral nutrition with carbohydrates is limited, inter alia, by the occurrence of a dose-dependent hyperlactataemia. Thiamine deficiency, which can be provoked by an eight weeks' diet which is deficient in thiamine, will produce clearly elevated lactate levels in rats, leading eventually to lactate acidosis as a result of glucose load, compared with a control group on a normal diet. It is recommended to initiate a high-dosage level thiamine therapy before parenteral feeding with carbohydrates, if thiamine deficiency appears possible on the grounds of previous history of the case (alcohol abuse) or because of the underlying disease (e.g. oesophageal strictures, carcinoma of the oesophagus).
D000138:Acidosis / Q000097:blood*; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D005947:Glucose / Q000009:adverse effects*; D005950:Glucose Solution, Hypertonic / Q000009:adverse effects*; D007773:Lactates / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D013832:Thiamine Deficiency / Q000097:blood*
D001639:Bicarbonates; D001786:Blood Glucose; D005950:Glucose Solution, Hypertonic; D007773:Lactates; D005947:Glucose
Glucoseinduzierte Hyperlactatämien bei Thiaminmangel.