Terbutaline aerosol from a metered dose inhaler with a 750-ml spacer or as a nebulized solution. Comparison of two delivery systems for bronchodilator aerosol.
The clinical effect of 1.0 mg terbutaline given as a pressurized aerosol with a 750-ml spacer was compared with that of 4.0 mg terbutaline given as a nebulized solution (Pari Inhalier Boy). No differences were found in the parameters measured--forced vital capacity, 1 s forced expiratory volume, forced mid-expiratory flow, and oscillatory resistance. The results indicate that the same clinical response to a given dose of a pressurized aerosol supplied with a 750-ml spacer has the same effect as a fourfold dose via a nebulizer. It is concluded that the more practical 750-ml spacer should be tried when contemplating nebulization therapy.
D000328:Adult; D000336:Aerosols; D000368:Aged; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012138:Respiratory Therapy; D013147:Spirometry; D013726:Terbutaline / Q000008:administration & dosage*
D000336:Aerosols; D013726:Terbutaline