Mucociliary flow in the nose during general and epidural anesthesia.
By means of the coloured indicator transport test (phenol red 3% in calcium-hydrogen-phosphate), mucociliary function in nose and pharynx was studied in 50 patients who underwent general or ocular surgery and in 10 healthy adult subjects. Patients were anesthetized with halothane, enflurane, NLA, and epidural analgesia. At the end of surgery, mucociliary function was significantly depressed (p less than 0.001) after halothane or enflurane anesthesia, but not after NLA or epidural analgesia. Six hours following enflurane anesthesia we still found a significant depression (p less than 0.001) of mucociliary function. No difference between halothane or enflurane was noted.
D000328:Adult; D000368:Aged; D000758:Anesthesia / Q000379:methods*; D000767:Anesthesia, Epidural; D002923:Cilia / Q000502:physiology*; D004737:Enflurane / Q000494:pharmacology; D005260:Female; D006221:Halothane / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009093:Mucus / Q000502:physiology*; D009297:Nasal Mucosa / Q000502:physiology*; D009458:Neuroleptanalgesia; D010614:Pharynx / Q000502:physiology
D004737:Enflurane; D006221:Halothane