title: Exercise training improves lipoprotein lipid profiles in patients with coronary artery disease.
abstract: The effects of endurance exercise training on plasma lipoprotein lipids were determined in 10 men, ages 46 to 62 years, with coronary artery disease (CAD). Patients maintained body weight, health-related behaviors, and stable diets throughout the program. Training was at 50% to 85% of maximal oxygen consumption (VO2 max) for 40 to 60 minutes, 3 to 5 days/week for 29 +/- 7 weeks. Training increased VO2 max (31 +/- 19%, p less than 0.001), reduced plasma cholesterol (C) (-8 +/- 4%, p less than 0.01), low-density lipoprotein-C (LDL-C) (-9 +/- 9%, p less than 0.01), and triglyceride (TG) (-13 +/- 32%, p less than 0.05) concentrations, and increased high-density lipoprotein-C (HDL-C) levels (11 +/- 13%, p less than 0.05) and HDL-C/LDL-C ratios (25 +/- 20%, p less than 0.01). Changes in LDL-C and VO2 max were correlated (r = -0.73, p +/- 0.01), while the changes in LDL-C and HDL-C each correlated inversely with pretraining lipoprotein levels (rLDL-C = -0.77, p less than 0.01; rHDL-C = -0.68, p less than 0.05). Thus potentially "antiatherogenic" benefits of exercise seem to be due to a training effect, since they correlate best with changes in VO2 max and are maximal in patients with initially low VO2 max, high LDL-C, and low HDL-C levels.
mesh_terms: D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003327:Coronary Disease / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000502:physiology; D005082:Physical Exertion; D010809:Physical Fitness; D012119:Respiration; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol; D010100:Oxygen