The effect of aerosol charge on the deposition and clearance of TiO2 particles in rats.
A titanium dioxide aerosol when generated by a Wright dust feed will have a higher electrostatic charge by a factor of 5.5 than one which has been discharged by a bipolar ion field produced by a 7.5 mCi 85Kr source. The deposition of particles in the lung of rats was lower by approximately 21% when an aerosol discharger was used. Particle clearance from the lung alveoli was not affected by the use of the discharger.
D000336:Aerosols; D000818:Animals; D007700:Kinetics; D007726:Krypton; D008168:Lung / Q000378:metabolism; D008297:Male; D011868:Radioisotopes; D051381:Rats; D014025:Titanium / Q000378:metabolism* / Q000633:toxicity; D014873:Water Pollutants / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D000336:Aerosols; D011868:Radioisotopes; D014873:Water Pollutants; D014874:Water Pollutants, Chemical; C009495:titanium dioxide; D007726:Krypton; D014025:Titanium