The effect of digoxin on 86rubidium uptake by erythrocytes from mothers and babies.
1 The uptake of 86rubidium by erythrocytes from mothers and babies has been used as a model system to investigate possible differences in sensitivity to digoxin in the very young. 2 While total 86rubidium uptake was not significantly different between mothers and babies, the digoxin-sensitive proportion was higher in neonatal erythrocytes. Neonatal cells were less sensitive to digoxin, demonstrated by the requirement for a larger amount of digoxin to inhibit 86rubidium uptake and this was accompanied by an increase in numbers of specific erythrocyte binding sites for digoxin. 3 These results provide further evidence in support of the hypothesis of decreased sensitivity to digoxin in the very young.
D004077:Digoxin / Q000008:administration & dosage / Q000494:pharmacology*; D004351:Drug Resistance; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011868:Radioisotopes / Q000378:metabolism*; D012413:Rubidium / Q000037:antagonists & inhibitors / Q000378:metabolism*
D011868:Radioisotopes; D004077:Digoxin; D012413:Rubidium