title: Effect of retinol on macromolecular synthesis in cultured cell lines.
abstract: The effects of retinol on SK Mel 28 and HeLa cell lines were studied with regard to DNA and protein synthesis. It was found that vitamin A added to the culture media at a 50 microM concentration causes a 60% inhibition of DNA synthesis, that the inhibition is reversible and that this treatment does not select retinol-resistant clones. The synthesis of cytoplasmic, acid-soluble nuclear proteins and that of non-histone chromosomal proteins is inhibited as soon as the vitamin reaches the cell.
mesh_terms: D004261:DNA Replication / Q000187:drug effects; D006367:HeLa Cells / Q000378:metabolism; D006801:Humans; D014176:Protein Biosynthesis / Q000187:drug effects*; D014801:Vitamin A / Q000494:pharmacology*
chemical_list: D014801:Vitamin A