The role of the GSH-disulfide status in the reversible and irreversible aggregation of human platelets.
Disturbance of cellular SH/SS status of blood platelets by diminution of the level of reduced glutathione is very sensitively reflected in changes of the in vitro aggregation. Additionally, disulfide-linked protein polymers are formed. One of these polymers participates in mediating platelet disaggregation.
D001391:Azo Compounds / Q000494:pharmacology*; D003958:Diamide / Q000494:pharmacology*; D005978:Glutathione / Q000031:analogs & derivatives* / Q000378:metabolism; D019803:Glutathione Disulfide; D006801:Humans; D066298:In Vitro Techniques; D007460:Iodoacetamide / Q000494:pharmacology*; D007461:Iodoacetates / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D013997:Time Factors
D001391:Azo Compounds; D007461:Iodoacetates; D003958:Diamide; D005978:Glutathione; D019803:Glutathione Disulfide; D007460:Iodoacetamide