[Tolerability of an aromatic retinoid (RO 10 9359, etretinate, Tigason, Roche). Research on its toxicity on hematopoietic, renal and thyroid functions. Interactions with the metabolism of natural retinoids].
59 patients with keratinisation diseases have been received RO 10 9359. There is a clinical medicum tolerance. Biologic controls have been carried out before and after a 3 month treatment. There is a good biological tolerance for the hematopoietic, glucidic, renal and thyroid functions. Thus the hepatic tolerance is poor for the patients with a predisposition for hepatic diseases (plethorics, alcoholics).
D002338:Carotenoids / Q000378:metabolism; D005050:Etretinate / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D012871:Skin Diseases / Q000188:drug therapy / Q000503:physiopathology; D013961:Thyroid Gland / Q000187:drug effects* / Q000503:physiopathology; D014212:Tretinoin / Q000031:analogs & derivatives*
D002338:Carotenoids; D014212:Tretinoin; D005050:Etretinate
Tolérance du rétinoïde aromatique (RO 10 9359, étrétinate, Tigason, Roche). Recherche d'une toxicité sur les fonctions hématopoïétique, rénale et thyroïdienne. Interactions avec le métabolisme des rétinoïdes naturels.