Effect of organo-tellurium compounds on the enzymatic alterations in rats.
An attempt has been made to correlate early toxicity of organo-tellurium (Te) compounds with enzymic alterations in liver, kidney, brain and serum at 1 and 3 days following single i.p. injections of bis-(tetraphenyl phosphonium) tetracyanato-bis-p-methoxy p-phenyl tellurate(IV) (TTMT) and bis-(tetraheptyl ammonium) tetraiodocyclopentane tellurate(IV) (TACT). These compounds, at 2 and 1 mg Te/kg body weight as TTMT and TACT, respectively, produced cholinergic signs and caused death within 3 days. Administration at maximum tolerable doses of 0.5 mg and 0.1 mg Te/kg body weight as TTMT and TACT, respectively, resulted in significant reduction of acetylcholine esterase (AChE) and monoamine oxidase (MAO) in serum and brain and by a significant decrease in hepatic glutathione and in glutathione-S-transferase (GST) and alkaline phosphatase in liver and kidney.
D000110:Acetylcholinesterase; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology; D002800:Cholinesterase Inhibitors; D004798:Enzymes / Q000097:blood / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008996:Monoamine Oxidase Inhibitors; D051381:Rats; D013691:Tellurium / Q000633:toxicity*
D002800:Cholinesterase Inhibitors; D004798:Enzymes; D008996:Monoamine Oxidase Inhibitors; C038435:bis(tetraheptylammonium)tetraiodocyclopentane tellurate(IV); C038436:bis(tetraphenylphosphonium)tetracyanato-bis-4-methoxy-4-phenyltellurate(IV); D005982:Glutathione Transferase; D000110:Acetylcholinesterase; D000469:Alkaline Phosphatase; D005978:Glutathione; D013691:Tellurium