The comparative bioavailability of slow release oral theophylline preparations.
Plasma concentrations of theophylline were determined in healthy volunteers following a single oral dose of six slow release preparations, immediately following a standard breakfast. There were no significant differences between the different preparations. The time taken to reach maximum plasma concentration, tmax, was found to be longer than in previous studies in which the drug was administered on an empty stomach.
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D003692:Delayed-Action Preparations; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D006801:Humans; D008297:Male; D013806:Theophylline / Q000008:administration & dosage / Q000378:metabolism*
D003692:Delayed-Action Preparations; D004040:Dietary Carbohydrates; D013806:Theophylline