title: Acetaminophen and aspirin challenges in subgroups of asthmatics.
abstract: To determine whether the different modes of action of aspirin and acetaminophen are associated with different incidences of bronchoconstriction, and whether there is cross-reactivity in terms of intolerance, selected asthmatics were challenged with both analgesics. Clinical profiles were observed to characterize more precisely the aspirin-intolerant asthmatic. Inhalational challenges with PGF2 alpha were then performed on nine selected subjects. It was determined that a positive history of aspirin intolerance is a reliable indicator of potential for anaphylactoid reactions but is not associated with any detectable risk of acetaminophen intolerance. Inhalational PGF2 alpha tends to involve the larger airways; oral aspirin affects both large and small airways.
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced*; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced*; D001985:Bronchial Provocation Tests; D004342:Drug Hypersensitivity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011460:Prostaglandins F / Q000494:pharmacology
chemical_list: D011460:Prostaglandins F; D000082:Acetaminophen; D001241:Aspirin