Influence of amino acid deficiency and tRNA aminoacylation on DNA synthesis and DNA polymerase activity during the secondary immune response in vitro.
DNA synthesis and DNA polymerase activity are increased when KLH-primed guinea-pig lymphocytes are restimulated in vitro with the homologous antigen. This response can be modulated by glutamine deficiency and by an inhibitor of the histidyl-tRNA synthetase.
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D000941:Antigens / Q000276:immunology; D004247:DNA / Q000096:biosynthesis*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D005973:Glutamine / Q000378:metabolism; D006168:Guinea Pigs; D006433:Hemocyanins; D006641:Histidinol / Q000494:pharmacology; D007156:Immunologic Memory; D007700:Kinetics; D008198:Lymph Nodes / Q000166:cytology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism*; D012343:RNA, Transfer / Q000378:metabolism*
D000596:Amino Acids; D000941:Antigens; D005973:Glutamine; D006641:Histidinol; D004247:DNA; D006433:Hemocyanins; D012343:RNA, Transfer; D004259:DNA-Directed DNA Polymerase; C032808:keyhole-limpet hemocyanin