Lymphocyte abnormalities in the BB rat.
The BB rat has a marked T cell lymphocytopenia, with a near absence of peripheral "helper" T cells recognized by monoclonal antibody W3/25 (W3/25+ T cells). The lymphocytes of the BB rat's spleen and thymus were examined for the presence of W3/25+ T cells, which were found to be absent in the spleen but present in normal amounts in the thymus. Concanavalin A (Con A) responsiveness was absent in the BB's peripheral blood and spleen but present in the thymus. Thus, in these three lymphoid compartments, Con A responsiveness directly correlated with the presence or absence of W3/25+ T cells. These lymphocyte abnormalities in the BB rat are notably different from lymphocyte changes present in human type I diabetes.
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000166:cytology; D008231:Lymphopenia / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains / Q000097:blood*; D013154:Spleen / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology
D003208:Concanavalin A