title: Carbohydrate metabolism of the brain in the ageing male garden lizard: effect of cold shock on mitochondrial respiration and lactate/pyruvate ratio.
abstract: Mitochondrial respiration with succinate as substrate increased and the mitochondrial protein content declined in the brain of the ageing male garden lizard. The lactate/pyruvate ratio of both blood and brain did not show appreciable changes with advancing age. Cold-shock treatment induced a significant rise in the respiratory rate of brain mitochondria of young but not appreciably in that of middle-aged and old lizards. On the other hand both mitochondrial protein content and lactate/pyruvate ratio increased only in the brain of cold-shocked lizards of the old age-group. The lactate/pyruvate ratio in blood remained unaltered following cold-shock treatment of lizards of all three age-groups.
mesh_terms: D000375:Aging; D000818:Animals; D001921:Brain / Q000378:metabolism*; D003080:Cold Temperature / Q000009:adverse effects; D005947:Glucose / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism; D008116:Lizards / Q000378:metabolism*; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D010101:Oxygen Consumption; D011773:Pyruvates / Q000378:metabolism
chemical_list: D007773:Lactates; D011773:Pyruvates; D005947:Glucose