Effects of propranolol and hydrocortisone pretreatment on radiation-induced myocardial injury in rats.
Earlier studies in our laboratory (23) showed evidence of dose-related acute injury to the myocardium after exposure of rats to ionizing radiation. Biochemical, histological, and electrocardiographic parameters were studied. In further continuation of this study, the effects of intervention by pretreatment with propranolol (10 mg/kg body weight) and hydrocortisone (10 mg/kg body weight) have been studied. The above drugs were administered to male albino rats weighing 150 to 200 g 30 min before exposure to 6000-rad single-dose gamma radiation over the precordial area. The parameters observed were cardiac glycogen, serum enzymes, lactate, pyruvate, blood sugar, adrenal ascorbic acid, and histology of the myocardium. The beneficial effects of this procedure are discussed.
D000818:Animals; D006321:Heart / Q000187:drug effects / Q000528:radiation effects*; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D011292:Premedication; D011433:Propranolol / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D051381:Rats
D011433:Propranolol; D006854:Hydrocortisone