Familial fragility on chromosome 16 (fra 16q22) enhanced by both interferon and Distamycin A.
A family with a "fragile site" at 16q22, inducible by both interferon and Distamycin A, is reported. Immunological problems were found in the family. In a sibship of ten, eight children had died in infancy. Our study led to the conclusions that interferon and Distamycin A induce fragility at the same site, which has the same characteristics as the spontaneous fragile site; that a viral hypothesis for this fragility may be supported; and that immunoincompetence of one kind or another must be considered in families presenting a fragile site at 16q22.
D000328:Adult; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002902:Chromosomes, Human, 16-18 / Q000648:ultrastructure*; D004214:Distamycins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D007621:Karyotyping; D008297:Male; D008677:Metaphase; D011758:Pyrroles / Q000494:pharmacology*
D004214:Distamycins; D007370:Interferon Type I; D011758:Pyrroles; C030000:stallimycin