title: Dengue virus-induced cytotoxic factor induces macrophages to produce a cytotoxin.
abstract: In our earlier studies we have observed that T lymphocytes of dengue type 2 virus (DV)-infected mouse spleen produce a cytotoxic factor (CF). In the present study it has been observed that CF induces mouse spleen and peritoneal macrophages to produce a cytotoxin (CF2) as has been revealed by DEAE-cellulose chromatography. CF2 is produced by an induction process and is present intracellularly as well as leaking out of the cells. CF2 kills most of the macrophages and some of the T cells, as observed with CF. It appears that CF2 is produced to amplify the effect of CF and/or for cooperative action with CF.
mesh_terms: D000818:Animals; D001202:Ascitic Fluid / Q000276:immunology; D002848:Chromatography, DEAE-Cellulose; D003602:Cytotoxicity, Immunologic; D003603:Cytotoxins / Q000096:biosynthesis*; D003715:Dengue / Q000276:immunology*; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology
chemical_list: D003603:Cytotoxins