[Action of heavy metal salts on the development of sea urchin embryos and on protein synthesis by the cells of transplantable mouse tumors].
Zu, Cu, Cd, Pb and Hg salts blocked the cleavage divisions in the sea urchin embryos and, in lesser concentrations, affected gastrulation and induced postgastrulation defects. The early embryo- and cytotoxic effects of Zn salts appear to be based on the inhibition of protein synthesis. Unithiol exerted a protective effect. All salts under study inhibited protein synthesis in the Ehrlich's ascite carcinoma and ascite hepatoma 22a cells; unithiol and other suldhydryl compounds exerted in this case a good protective effect against Cd salts only.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects* / Q000378:metabolism; D004625:Embryo, Nonmammalian; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D008670:Metals / Q000633:toxicity*; D051379:Mice; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D009368:Neoplasm Transplantation; D014176:Protein Biosynthesis; D011506:Proteins / Q000037:antagonists & inhibitors; D012617:Sea Urchins
D008670:Metals; D009363:Neoplasm Proteins; D011506:Proteins
Deĭstvie soleĭ tiazhelykh metallov na razvitie zarodysheĭ morskikh ezheĭ i na sintez belkov kletkami myshinykh perevivnykh opukholeĭ.