title: Cytogenetic effect of chlordiazepoxide on the bone marrow cells of Swiss mice in vivo.
abstract: Chromosomal preparations were examined for structural and numerical abnormalities induced by chlordiazepoxide (CDZ) in mice which received either a single oral dose (20 mg/kg) or multiple doses (10, 20, 40 and 80 mg/kg) for time-response and dose-response studies, respectively. The sampling was done at different post-treatment hours. The structural aberrations recorded were mostly of the chromatid type. CDZ induced a significant increase in chromosomal aberration frequencies at all sampling hours with a peak at 32 h post-treatment. In dose-response studies all the dose groups showed a significant increase over controls but the effect was maximum at the lowest dose level.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002707:Chlordiazepoxide / Q000008:administration & dosage / Q000494:pharmacology*; D002869:Chromosome Aberrations / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D013997:Time Factors
chemical_list: D002707:Chlordiazepoxide