[Effect of cholinolytics on thermoregulation processes in hypothermia].
Acute experiments on rats were made to study variations of the hypothermia development ratio (HDR) under the effect of cholinolytics at mild, medium and deep hypothermia stages, corresponding with 33,26 and 19 degrees C of rectal temperature. Amizyl (20 mg/kg) and spasmolytin (10 mg/kg) were used as central cholinolytics, whereas metacin (20 mg/kg), isoverin (10 mg/kg) and diplacin (8 mg/kg) as peripheral ones. The character of the action of central cholinolytics of the HDR is largely determined by the hypothermia stage, while that of peripheral ones by the type and localization of cholinoreceptors under blockade.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects*; D007035:Hypothermia / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D008433:Mathematics; D010276:Parasympatholytics / Q000494:pharmacology*; D051381:Rats; D013814:Thermal Conductivity
D010276:Parasympatholytics
Vliianie kholinolitikov na protsessy termoreguliatsii pri gipotermii.