title: Serotonin stimulates prolactin secretion in the hypophysectomized adenohypophyseal grafted rat.
abstract: Normal male, oestrogen (F2) primed male and hypophysectomized adenohypophyseal grafted male rats (HAG rats) were used in the experiments. Serotonin creatinine sulphate was injected as a bolus via an indwelling atrial cannula in the conscious free moving rat. Serotonin caused a dose-dependent increase in plasma prolactin (Prl) in normal (1, 3 and 10 mg/kg serotonin) and E2 primed (1 and 3 mg/kg serotonin) male rats that began immediately after injection and reached a peak within 12-15 min of injection. Oestrogen priming significantly increased the magnitude of the response to serotonin. To analyze the site of action of serotonin in the rat, serotonin (1 mg/kg) was injected into HAG rats. Serotonin increased plasma Prl in this rat preparation, indicating that serotonin acts directly on the ectopic pituitary.
mesh_terms: D000818:Animals; D004958:Estradiol / Q000494:pharmacology; D007016:Hypophysectomy; D008297:Male; D010903:Pituitary Gland, Anterior / Q000637:transplantation*; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*
chemical_list: D012701:Serotonin; D004958:Estradiol; D011388:Prolactin