title: Gossypol binds to a high-affinity binding site on human serum albumin.
abstract: The triterpene gossypol competes with bilirubin for a high-affinity binding site on human serum albumin. Similar competition between bilirubin and gossypol occurs in the binding of these ligands to the glutathione S-transferases from human liver and placenta. In each case, gossypol and bilirubin exhibit similar binding constants. The binding properties of gossypol may generally mimic those of bilirubin.
mesh_terms: D001663:Bilirubin / Q000097:blood*; D001665:Binding Sites; D001667:Binding, Competitive; D002352:Carrier Proteins / Q000097:blood; D006072:Gossypol / Q000097:blood*; D006801:Humans; D011485:Protein Binding; D012709:Serum Albumin / Q000032:analysis*
chemical_list: D002352:Carrier Proteins; D012709:Serum Albumin; C029783:bilirubin binding protein, human; D006072:Gossypol; D001663:Bilirubin