A quantitative study of nuclear DNA of trophoblastic cells analysis of nuclear DNA distribution and clinical outcome of hydatidiform mole.
Microspectrophotometric measurements of the nuclear DNA contents of Feulgen-stained trophoblastic cells were made in the cases of 54 normal pregnancies, 10 missed abortions, 118 hydatidiform moles, 11 invasive moles, and 9 choriocarcinomas. The position of the main peak and the range of nuclear DNA distribution correlated well with the severity of the trophoblastic disease. A statistically significant correlation was found between the position of the main peak and the occurrence of secondary trophoblastic disease from hydatidiform mole. Histological grading of hydatidiform mole did not show a good correlation with regard to the occurrence of secondary trophoblastic disease from hydatidiform mole.
D002467:Cell Nucleus / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000032:analysis*; D011247:Pregnancy; D011379:Prognosis; D014327:Trophoblasts / Q000032:analysis*; D014594:Uterine Neoplasms / Q000032:analysis*
D004273:DNA, Neoplasm