Chromosome aberrations and sister chromatid exchanges in styrene-exposed workers with reference to their smoking habits.
The incidences of chromosome aberrations and the frequencies of sister chromatid exchanges (SCE) were investigated in cultured lymphocytes of 18 styrene-exposed workers in comparison with six controls. There was a marginal increase in the incidence of structural chromosomal aberrations in first-division metaphases in the styrene-exposed workers, as compared with the nonexposed controls. However, there was no difference in SCE frequencies. When each group was divided into smokers and nonsmokers, styrene-exposed smokers tended to have higher SCE frequencies than styrene-exposed nonsmokers. Furthermore, cell proliferation was inhibited in styrene-exposed workers (both smokers and nonsmokers) and control smokers.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000393:Air Pollutants / Q000633:toxicity*; D000395:Air Pollutants, Occupational / Q000633:toxicity*; D001973:Bromodeoxyuridine / Q000494:pharmacology; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003434:Crossing Over, Genetic / Q000187:drug effects*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D012907:Smoking; D020058:Styrene; D013343:Styrenes / Q000633:toxicity* / Q000652:urine
D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D013343:Styrenes; D020058:Styrene; D001973:Bromodeoxyuridine