Early-onset preeclampsia, triploidy and fetal hydrops.
Early-onset preeclampsia (16-24 weeks) is frequently associated with fetal and placental anomalies. Hydatidiform mole, fetoplacental triploidy with partial molar changes and idiopathic hydrops fetalis are commonly associated ones. Two patients had severe, early-onset preeclampsia and ultrasonically documented fetal anomalies, one fetal triploidy, the other idiopathic hydrops with normal karyotype. The management of early-onset preeclampsia benefits from ultrasonography, and an aggressive search for fetal anomalies is recommended. Seventy-two percent of cases of early-onset preeclampsia in our institution were associated with significant fetal and placental malformations. An immunologic basis of the preeclampsia in these cases seems likely but remains unproven.
D000328:Adult; D000782:Aneuploidy; D004487:Edema / Q000150:complications* / Q000175:diagnosis; D005260:Female; D005315:Fetal Diseases / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D011225:Pre-Eclampsia / Q000150:complications* / Q000175:diagnosis; D011247:Pregnancy