Vancomycin pharmacokinetics in patients with peritonitis on peritoneal dialysis.
Vancomycin pharmacokinetics were studied in four patients with peritonitis undergoing chronic intermittent peritoneal dialysis. Serum levels exceeding 4.0 micrograms/ml were maintained for 8 and 13 days after a single 1-g intravenous dose. Vancomycin serum concentrations measured before, during, and upon completion of dialysis revealed no appreciable decline. Peritoneal fluid concentrations in two patients exceeded 4.0 micrograms/ml for more than 12 days.
D000368:Aged; D001202:Ascitic Fluid / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010538:Peritonitis / Q000378:metabolism*; D013997:Time Factors; D014640:Vancomycin / Q000008:administration & dosage / Q000378:metabolism*
D014640:Vancomycin