A reproducible spinal cord injury model in the cat.
Allen's weight-drop method for producing experimental spinal cord injuries was improved by placing a curved stainless steel plate anterior to the spinal cord to provide a smooth, hard surface for the receipt of posterior cord impact. In addition, an electronic circuit was used to ensure that cord injury was produced by a single impact, thereby enhancing the reproducibility of the injury mechanism. Using a spinal cord injury model with these modifications, the author found that the recovery of hindlimb function and the histopathological appearance of the injured cord 6 weeks after upper lumbar injury were closely related to injury magnitude. The curve of functional recovery versus injury magnitude has a sharp transition centered at 10 gm X 15 cm, and indicates that an injury of 10 gm X 20 cm produces a "threshold" lesion suitable for the future evaluation of spinal cord treatment methods.
D000818:Animals; D002415:Cats; D004195:Disease Models, Animal; D008297:Male; D013119:Spinal Cord Injuries / Q000503:physiopathology*; D013523:Surgical Equipment