Evidence of a possible direct action of Danazol on the human ovary.
Strong evidence is presented that Danazol might exert a direct action on the human ovary by binding to receptor-like receptors for progesterone and testosterone, in concentrations well within the pharmacological range of the treated patient. The possible significance of this finding in understanding Danazol's mode of action is discussed.
D000328:Adult; D003613:Danazol / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D006801:Humans; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism; D011245:Pregnadienes / Q000494:pharmacology*; D011944:Receptors, Androgen; D011980:Receptors, Progesterone / Q000378:metabolism; D011987:Receptors, Steroid / Q000378:metabolism
D011245:Pregnadienes; D011944:Receptors, Androgen; D011980:Receptors, Progesterone; D011987:Receptors, Steroid; D003613:Danazol