Intranuclear inclusions containing melanosomes observed after PUVA therapy: a study of five psoriatic patients.
Skin biopsies were obtained before and after PUVA therapy from five psoriatic patients and epidermal melanocytes surveyed for the presence of intranuclear melanosome-like bodies and nuclear bodies. Intranuclear melanosome-like bodies were observed after PUVA therapy whereas none were found before therapy. Nuclear bodies were found to increase in frequency after PUVA therapy. Remnants of a nuclear envelope membrane were not found around the intranuclear melanosome-like bodies. Nor were remnants of a nuclear envelope membrane found in or around the nuclear bodies. The results are discussed in view of the possible sites of origin of intranuclear melanosome-like bodies and nuclear bodies.
D002467:Cell Nucleus / Q000648:ultrastructure*; D006801:Humans; D008544:Melanocytes / Q000648:ultrastructure*; D008954:Models, Biological; D009685:Nuclear Envelope / Q000648:ultrastructure; D011701:PUVA Therapy; D011565:Psoriasis / Q000188:drug therapy / Q000473:pathology*; D012867:Skin / Q000187:drug effects / Q000648:ultrastructure*