title: Response of extravascular lung water to intraoperative fluids.
abstract: The effect of Ringer's Lactate (RL) and a colloid containing salt solution Plasmanate (PL) on extravascular lung water (EVLW) during aortic surgery was evaluated in a prospective study of 18 patients. Measured blood loss was replaced with packed red blood cells. In addition to red blood cell replacement, either RL or PL was infused (1) to maintain the cardiac output (CO) equal to or greater than the preoperative value, (2) to maintain the pulmonary capillary wedge pressure (PCWP) plus or minus 2 mmHg of preoperative values, and (3) to keep the urinary output greater than or equal to 30 cc/hr. Cardiac output, EVLW, PCWP, serum colloid osmotic pressure (COP), and intrapulmonary shunt fraction (Qs/Qt) were measured serially. All baseline values were similar between groups. The groups were well matched for age, associated disease, operating time, blood loss, and blood transfusions. During operation, the RL group required two times the rate of infusion of the PL group. Urine flow rates were similar on the day of surgery, but by postoperative days one and two, the PL group had approximately one-half of the urine flow rate compared to the RL group. Cardiac output and Qs/Qt increased in both groups. EVLW did not change after operation in either group, despite marked decrease in COP in the RL group. These data indicate that crystalloid resuscitation to physiologic endpoints does not increase extravascular lung water. Thus, manipulation of COP by PL was unnecessary in these patients.
mesh_terms: D000368:Aged; D001011:Aorta / Q000601:surgery; D001794:Blood Pressure / Q000187:drug effects; D001798:Blood Proteins / Q000627:therapeutic use*; D001834:Body Water / Q000187:drug effects*; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007430:Intraoperative Care; D007552:Isotonic Solutions / Q000627:therapeutic use*; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D011897:Random Allocation; D000077325:Ringer's Lactate; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D012712:Serum Globulins
chemical_list: D001798:Blood Proteins; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D012709:Serum Albumin; D012712:Serum Globulins; C008930:plasma protein fraction; D000075462:Serum Albumin, Human