A technique for laser Raman spectroscopic studies of isolated cell populations.
A new method has been developed for the study of cell populations by laser Raman spectroscopy. Resonance Raman spectra of a small number of living or fixed tumor cells (ca 5000) treated with the antitumor agent adriamycin have been successfully obtained. This new approach leads to a better understanding of the molecular interactions between drug and biological targets, i.e., nuclear DNA at the cellular level.
D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects*; D004317:Doxorubicin / Q000494:pharmacology; D006801:Humans; D007834:Lasers; D013059:Spectrum Analysis, Raman / Q000379:methods*
D004317:Doxorubicin