Endocytosis and intracellular protein degradation in cystic fibrosis fibroblasts.
Normal rates of pinocytosis of [3H]sucrose were measured in cystic fibrosis fibroblasts, and were not affected by the addition of cystic fibrosis serum. Bulk protein degradation (a significant proportion of which occurs intralysosomally following autophagy) and its regulation by growth state was apparently identical in normal and cystic fibrosis cultures.
D002460:Cell Line; D003550:Cystic Fibrosis / Q000503:physiopathology*; D005347:Fibroblasts / Q000502:physiology*; D006801:Humans; D007700:Kinetics; D007930:Leucine / Q000378:metabolism; D010873:Pinocytosis; D011506:Proteins / Q000378:metabolism*; D013395:Sucrose / Q000378:metabolism
D011506:Proteins; D013395:Sucrose; D007930:Leucine