Aspects of the chemical stability of mitomycin and porfiromycin in acidic solution.
Aspects of the degradations of mitomycin and porfiromycin were studied. The initial degradation processes of the compounds in an acidic medium were investigated. Influences of pH, buffers, and other additives such as halogenides and dioctyl sodium sulfosuccinate [sodium 1,4-bis(2-ethylhexyl)sulfosuccinate] were studied. The hydrogen ion catalyzes the degradation of both the uncharged and the protonated species. Anions also promote the degradation of the compounds in an acidic medium. Rate constants for all of the catalytic reactions could be determined. From the pH profiles, after correction for buffer influences, accurate pKa values for the aziridine nitrogens could be obtained. The protective influence of the dioctyl sulfosuccinate ion could be explained. From the data obtained a plausible mechanism for the initial acidic degradation reactions was developed.
D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008937:Mitomycins; D010710:Phosphates / Q000032:analysis; D011160:Porfiromycin; D012996:Solutions; D013696:Temperature; D013816:Thermodynamics
D008937:Mitomycins; D010710:Phosphates; D012996:Solutions; D011160:Porfiromycin