Ileal enteroglucagon cells after ileal-duodenal transposition in the rat.
The changes occurring in the ileal wall and in enteroglucagon cells were studied in a rat model of intestinal adaptation, obtained by the transposition of a segment of distal ileum into the mid-duodenum (6 rats, compared with 6 transected controls). After 40 days, the transposed ileal segment, compared to the equivalent segment in the controls, showed striking increase in weight, especially of the epithelium (1,585 +/- 127 vs. 305 +/- 42 mg, mean +/- SEM, p less than 0.0005). The calculated weight of enteroglucagon cells in the segment showed a smaller, but significant increase (1.7 +/- 0.3 vs. 0.8 +/- 0.2 micrograms, p less than 0.05). Plasma enteroglucagon was markedly raised (239 +/- 28 vs. 61 +/- 7.1 pmol/l, p less than 0.0005) and showed a greatly increased meal-stimulated response (1,521 +/- 284 vs. 83 +/- 43 pmol, p less than 0.0005), thus suggesting hyperactivity of enteroglucagon cells.
D000818:Animals; D004386:Duodenum / Q000601:surgery; D005768:Gastrointestinal Hormones / Q000032:analysis*; D004763:Glucagon-Like Peptides / Q000032:analysis* / Q000097:blood; D007082:Ileum / Q000032:analysis / Q000473:pathology* / Q000637:transplantation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005768:Gastrointestinal Hormones; D004763:Glucagon-Like Peptides