title: Monitoring aminophylline therapy using Jusko's dosage guidelines.
abstract: Treatment with aminophylline, according to the nomogram published by Jusko and coworkers, was monitored in 13 patients suffering from acute exacerbations of COPD. After 24 h of therapy, the clinical state, the pO2 and the pCO2 values were markedly improved. Theophylline plasma concentrations were maintained within the therapeutic range. A slight but noticeable increase of drug serum levels during therapy could be related to changes in the arterial pH; the implications of this finding are discussed.
mesh_terms: D000328:Adult; D000368:Aged; D000628:Aminophylline / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy; D008875:Middle Aged; D013806:Theophylline / Q000097:blood
chemical_list: D000628:Aminophylline; D013806:Theophylline