Plasma lipid concentrations and enzyme activities in Nagase analbuminemia rats (NAR).
Plasma lipid concentrations in NAR (Nagase Analbuminemia Rats) of 4 to 52 weeks old were examined. Plasma enzymes of NAR were also measured in relation to liver function. The concentrations of total lipid, total cholesterol, phospholipid and triglyceride tended to be increased in NAR, while that of non-esterified fatty acid (NEFA) was decreased. The lipid levels (except NEFA) were especially high in female adult NAR, and they were increased with aging. The effect of 17 beta-estradiol or testosterone administration on serum lipid concentrations was studied in gonadectomized NAR. Administration of 17 beta-estradiol to gonadectomized NAR increased lipid concentrations, while testosterone administration did not affect lipid levels. The effect of albumin injection on lipid concentrations in female NAR was also investigated. Albumin treatment to female NAR lowered serum lipid concentrations. Plasma glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, lactate dehydrogenase and leucine aminopeptidase activities were higher in NAR than in normal rats. Plasma alkaline phosphatase and cholinesterase activities of NAR were similar to those of normal rats.
D000367:Age Factors; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002369:Castration; D004195:Disease Models, Animal; D004958:Estradiol / Q000494:pharmacology; D005215:Fasting; D005260:Female; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007931:Leucyl Aminopeptidase / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains; D012709:Serum Albumin / Q000172:deficiency*; D013739:Testosterone / Q000494:pharmacology
D008055:Lipids; D012709:Serum Albumin; D013739:Testosterone; D004958:Estradiol; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D007931:Leucyl Aminopeptidase