[Disorders of calcium metabolism and ossification caused by anticonvulsants].
Disturbances of Calcium-metabolism and of ossification are well known and well documented side-effects of anticonvulsant drugs since the first description in 1967. Elevated alkaline phosphatase and hypocalcemia till generalised osteoporosis and vitamin-D-sensitive rickets can be seen. The primary cause of these dose-related disturbances is an accelerated elimination of vitamin D because of induction of microsomal enzymes in the liver by anticonvulsant drugs; a suboptimal vitamin-D-intake and reduced sunlight exposure in institutionalised patients are often combined causative factors. In all patients treated with anticonvulsant drugs a sufficient supplementation with vitamin D is necessary.
D000469:Alkaline Phosphatase / Q000097:blood; D000927:Anticonvulsants / Q000009:adverse effects*; D002118:Calcium / Q000097:blood; D002648:Child; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D006996:Hypocalcemia / Q000139:chemically induced*; D010024:Osteoporosis / Q000139:chemically induced*; D012279:Rickets / Q000139:chemically induced*; D014807:Vitamin D / Q000627:therapeutic use
D000927:Anticonvulsants; D014807:Vitamin D; D000469:Alkaline Phosphatase; D002118:Calcium
Störungen des Kalziumstoffwechsels und der Ossifikation durch Antikonvulsiva.