[Frequency of sister chromatid exchanges in oncological patients during treatment with cyclophosphane].
The sister chromatid exchange (SCE) level in patients with cancer of lungs before treatment did not differ from the mean number of SCE in healthy donors. In the process of a cyclophosphane treatment the SCE frequency in the patient lymphocyte culture increased with the drug doses of 4 and 5 g. Analysis of the ratio of cells in mitoses I, II and III revealed no differences in the cell cycle rate for groups of healthy donors, patients before the treatment, and treated patients.
D002478:Cells, Cultured; D003434:Crossing Over, Genetic / Q000187:drug effects*; D003520:Cyclophosphamide / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics*; D008214:Lymphocytes / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013997:Time Factors
D003520:Cyclophosphamide
Chastota sestrinskikh khromatidnykh obmenov u onkologicheskikh bol'nykh v protsesse lecheniia tsiklofosfanom.