Guanosine triphosphate activation of brain adenylate cyclase: enhancement by long-term antidepressant treatment.
Activation of adenylate cyclase by a stable guanosine 5'-triphosphate analog was augmented in brain membrane preparations from rats treated on a long-term basis with tricyclic antidepressants or electroconvulsive shock. These treatments may facilitate cyclase activation by promoting the interaction of the regulatory and catalytic subunits of the enzyme. This finding suggests a possible mechanism for the changes in sensitivity to various neurotransmitters seen after antidepressant administration.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology*; D002462:Cell Membrane / Q000378:metabolism; D004565:Electroconvulsive Therapy; D004789:Enzyme Activation; D006160:Guanosine Triphosphate / Q000494:pharmacology*; D008297:Male; D009928:Organ Specificity; D051381:Rats
D000929:Antidepressive Agents, Tricyclic; D006160:Guanosine Triphosphate; D000262:Adenylyl Cyclases