title: [Significance of elevated hemoglobulin A1c for the pathogenesis of diabetic retinopathy].
abstract: The hemoglobin of 70 diabetics with retinopathy was analysed. 56 patients had pathologically elevated values, 12 values were within the upper normal limit and in 2 cases the findings were normal. This hemoglobin variant is characterized by an increased affinity of oxygen. Clinically and pathologically speaking the elevated HbA1c value could be a causal factor in diabetic retinopathy. Comparisons with sickle cell anemia and thalassemia seem to indicate that hemoglobinopathy and retinopathy are pathogenetically related.
mesh_terms: D003930:Diabetic Retinopathy / Q000097:blood / Q000209:etiology*; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D012016:Reference Values
chemical_list: D006442:Glycated Hemoglobin
vernacular_title: Die Bedeutung des erhöhten Hämoglobin AIc für die Pathogenese der diabetischen Retinopathie.