Potentiation of magnesium-induced neuromuscular weakness by gentamicin.
A term neonate with hypermagnesemia secondary to maternal administration of MgSO4 for pre-eclampsia had a respiratory arrest after receiving gentamicin im. The neuromuscular tracings and sequential physician exams done before and after administering gentamicin suggest aminoglycosides may potentiate a magnesium-induced impairment of neuromuscular transmission and cause muscular weakness in neonates.
D003422:Critical Care; D004357:Drug Synergism; D005260:Female; D005839:Gentamicins / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D008274:Magnesium / Q000009:adverse effects*; D009468:Neuromuscular Diseases / Q000139:chemically induced*
D005839:Gentamicins; D008274:Magnesium