Effect of diet on adjuvant-induced disease and mitogenic responses of Fisher rats.
Fisher rats from a inbred colony, when fed on a salt-free high-protein diet, developed only a mild arthritis after adjuvant injection. Their spleen cells failed to respond in vitro to concanavalin A (a T-cell mitogen), although they possessed a B-cell function of plaque formation to sheep red blood cells. When a full salt supplement was included in the diet, or magnesium or copper or zinc was included in the drinking water, adjuvant-induced arthritis was severe and the response to the T-cell mitogen was restored. The above results suggest that these trace elements may stabilize or activate certain cell populations needed for some immune responses in rats.
D000818:Animals; D001168:Arthritis / Q000517:prevention & control*; D001169:Arthritis, Experimental / Q000517:prevention & control*; D003208:Concanavalin A / Q000494:pharmacology; D003300:Copper / Q000494:pharmacology; D004039:Diet, Sodium-Restricted; D005620:Freund's Adjuvant; D008213:Lymphocyte Activation / Q000187:drug effects; D008274:Magnesium / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344; D013154:Spleen / Q000166:cytology; D015032:Zinc / Q000494:pharmacology
D003208:Concanavalin A; D003300:Copper; D005620:Freund's Adjuvant; D008274:Magnesium; D015032:Zinc