Left ventricular function at rest and during exercise in congenital complete heart block: a radionuclide angiographic evaluation.
This study evaluates intrinsic cardiac performance during upright exercise in patients with congenital complete heart block. Left ventricular ejection fraction and volume were measured at rest and peak upright exercise with radionuclide angiography in 5 patients aged 11 to 39 years with congenital complete heart block: 4 were in New York Heart Association class I and 1 was in class II. The resting cardiac output was maintained at a normal level by an increase in end-diastolic volume rather than by a decrease in end-systolic volume. The left ventricular ejection fraction was normal at rest in all patients, but an abnormal response to exercise was noted in 3 patients. There was no appreciable change in the end-diastolic volume during exercise. Thus, patients with congenital complete heart block utilize the Starling mechanism to maintain normal resting cardiac output, but the response to exercise is usually abnormal even in the absence of symptoms.
D000293:Adolescent; D000328:Adult; D002302:Cardiac Output; D002306:Cardiac Volume; D002648:Child; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000503:physiopathology; D006327:Heart Block / Q000151:congenital* / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D013318:Stroke Volume