Cardiovascular effects of dopamine in developing swine.
Cardiac function and peripheral blood flows were measured before and during single intravenous injections of dopamine (2-25 micrograms/kg) in developing and mature swine anesthetized with pentobarbital. A positive inotropic effect was observed in even the youngest swine. Renal vasoconstriction was observed even after low doses of dopamine in animals younger than 1 month of age, and femoral vasoconstriction in animals younger than 2 weeks of age, unless alpha-adrenergic receptors were blocked by phentolamine. We concluded that the vasodilator responses to dopamine are slower to develop in the renal than in the femoral circulation.
D000367:Age Factors; D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects / Q000254:growth & development*; D002339:Carotid Arteries / Q000502:physiology; D004298:Dopamine / Q000494:pharmacology*; D005263:Femoral Artery / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D010646:Phentolamine / Q000494:pharmacology; D012079:Renal Circulation / Q000187:drug effects; D013552:Swine / Q000254:growth & development*
D004298:Dopamine; D010646:Phentolamine