[Antihypoxic effect of tisochromide (16-244) in comparison with piracetam].
The antihypoxic activity of Tisochromide (3-[4'-dimethylamino-4'-methylpentyl(2')-carbamoyl]-6,7-dimethoxy-1-thiaisochroman-1,1-dioxide), a substance of clinically antidepressant action, is studied on three hypoxia models and compared with that of the nootropic agent Piracetam: -- Tisochromide produces a dosis-dependent prolongation of the survival time of mice exposed to nitrogen hypoxia. -- The hypoxia-induced increase of lactate and pyruvate in the mouse brain is inhibited by this preparation. -- As to anoxia-induced electroencephalographic changes in the rat. Tisochromide increases the cerebral resistance against anoxia and shortens the isoelectric part of the encephalogram as well as the postanoxic phase of normalization.
D000818:Animals; D001921:Brain / Q000378:metabolism; D004569:Electroencephalography; D006571:Heterocyclic Compounds / Q000627:therapeutic use*; D000860:Hypoxia / Q000188:drug therapy* / Q000503:physiopathology; D007773:Lactates / Q000378:metabolism; D051379:Mice; D010075:Oxathiins / Q000627:therapeutic use*; D010889:Piracetam / Q000627:therapeutic use*; D011760:Pyrrolidinones / Q000627:therapeutic use*; D011773:Pyruvates / Q000378:metabolism; D051381:Rats
D006571:Heterocyclic Compounds; D007773:Lactates; D010075:Oxathiins; D011760:Pyrrolidinones; D011773:Pyruvates; C022101:tisocromide; D010889:Piracetam
Untersuchungen zur antihypoxischen Wirksamkeit von Tisochromid (16-244) im Vergleich zu Piracetam.