title: Sulfation preceding deiodination of iodothyronines in rat hepatocytes.
abstract: In man and animals iodothyronines are metabolized by deiodination and conjugation with glucuronic acid or sulfate. Until now these processes have been regarded as independent reactions. However, in the present study a close interaction of these pathways was observed in the hepatic metabolism of 3,3'-diiodothyronine and 3,3',5-triiodothyronine. Studies with rat hepatocytes and liver microsomes indicated that sulfation of the phenolic hydroxyl group facilitates the deiodination of these compounds.
mesh_terms: D000818:Animals; D004104:Diiodothyronines / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism; D011441:Propylthiouracil / Q000494:pharmacology; D051381:Rats; D013431:Sulfates / Q000378:metabolism; D013963:Thyroid Hormones / Q000378:metabolism*; D014284:Triiodothyronine / Q000378:metabolism
chemical_list: D004104:Diiodothyronines; D013431:Sulfates; D013963:Thyroid Hormones; D014284:Triiodothyronine; D011441:Propylthiouracil