Histamine and immune reactions. 3. Inhibition of early events of human lymphocyte activation by histamine.
Histamine inhibits the chemiluminescence response of human lymphocytes to Concanavalin A by interfering with early triggering events. The inhibition seems to be mediated via H2 receptors, acts immediately, and is reversible by washing. A longer incubation in a histamine-containing medium induces a refractory state of the cells. The inhibitory effect described here is compared with the inhibitory action of histamine in the lymphocyte transformation test.
D003208:Concanavalin A / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects*; D011744:Pyrimidinones / Q000494:pharmacology
D011744:Pyrimidinones; D003208:Concanavalin A; C033275:SK&F 93479; D006632:Histamine