Iso-effect tables and therapeutic ratios for epidermoid cancer and normal tissue stroma.
Available literature on radiation injury to normal tissue stroma and ablation of epidermoid carcinoma was surveyed. Computer programs (RAD3 and RAD1) were then used to derive cell kinetic parameters and generate iso-effect tables for the relevant tissues. The two tables provide a set of limiting doses for tolerance of normal connective tissue (16% risk of injury) and for ablation of epidermoid cancer (16% risk of recurrence) covering a wide range of treatment schedules. Calculating the ratios of normal tissue tolerance to tumor control doses for each treatment scheme provides an array of therapeutic ratios, from which appropriate treatment schemes can be selected.
D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D002470:Cell Survival / Q000528:radiation effects; D003201:Computers; D003238:Connective Tissue / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D010100:Oxygen; D013997:Time Factors
D010100:Oxygen