Pharmacokinetics of pentobarbital in the dog.
The pharmacokinetics of pentobarbital were studied after i.v. administration of a 30-mg/kg dose to five dogs. Pentobarbital plasma concentrations were measured with a new gas chromatographic method, utilizing on-column methylation of pentobarbital and as a butabarbital internal standard. The kinetics of pentobarbital distribution and elimination were analyzed with a three-compartment open mammillary model. The elimination-phase half-life of pentobarbital was 8.2 +/- 2.2 hr. The steady-state volume of pentobarbital distribution was 1.08 +/- 0.21 liters/kg and the elimination clearance was 0.0013 +/- 0.0004 liters/min X kg. Threshold pentobarbital concentrations required to suppress the corneal reflex and withdrawal response to pain were 26.4 +/- 4.6 and 23.0 +/- 2.9 micrograms/ml, respectively. These results should facilitate the design of i.v. anesthetic regimens with pentobarbital.
D000771:Anesthesia, Intravenous / Q000592:standards; D000818:Animals; D001810:Blood Volume / Q000187:drug effects; D004285:Dogs; D005260:Female; D006400:Hematocrit; D007700:Kinetics; D008297:Male; D010146:Pain / Q000503:physiopathology; D010424:Pentobarbital / Q000008:administration & dosage / Q000097:blood*; D012025:Reflex, Pupillary / Q000187:drug effects
D010424:Pentobarbital