Complement receptor mediates enhanced flavivirus replication in macrophages.
Evidence is presented that M phi complement receptors (CR3) mediate IgM-dependent enhancement of flavivirus replication in the presence of complement. Enhancement is blocked by pretreatment of macrophages with monoclonal antibody Ml/70, which inhibits CR3 binding, but not by pretreatment with monoclonal antibody 2.4G2, which inhibits FcR binding.
D000818:Animals; D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral / Q000502:physiology; D002460:Cell Line; D007075:Immunoglobulin M / Q000502:physiology; D008264:Macrophages / Q000276:immunology / Q000382:microbiology*; D051379:Mice; D011951:Receptors, Complement / Q000502:physiology*; D014779:Virus Replication; D014902:West Nile virus / Q000276:immunology / Q000502:physiology*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D007075:Immunoglobulin M; D011951:Receptors, Complement