Modulation of presynaptic cholinergic receptors by adrenergic drugs.
Some adrenergic drugs were tested for their ability to interact with the stimulatory activity of scopolamine on Ach output from brain cortex. The noradrenergic neurotoxin DSP4 was the most potent in depressing the effect of the anticholinergic drug and behaved like a potent alpha 2-agonist and alpha 1-antagonist on nervous peripheral structures. This finding supports the view of a connection between presynaptic adrenergic and muscarinic receptors.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010646:Phentolamine / Q000494:pharmacology; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011950:Receptors, Cholinergic / Q000187:drug effects*; D012601:Scopolamine / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology*
D011950:Receptors, Cholinergic; D013566:Sympathomimetics; D012601:Scopolamine; D000109:Acetylcholine; D011224:Prazosin; D010646:Phentolamine