Changes in QTc interval induced with Renografin-76 and Hypaque-76 during coronary arteriography.
Renografin-76 and Hypaque-76 are both recommended for coronary arteriography. Both have the same osmolality and iodine concentration, but differ in their calcium binding properties. After selective right or left coronary arteriography in patients, Renografin-76 caused significantly more prolongation of the QTc interval than did Hypaque-76. Less calcium binding in the Hypaque formulation is probably responsible for its lesser effect on the QTc interval. This study suggests, but does not prove, that Hypaque-76 is safer than Renografin-76 for coronary arteriography.
D003287:Contrast Media / Q000494:pharmacology*; D017023:Coronary Angiography; D003973:Diatrizoate / Q000494:pharmacology; D003974:Diatrizoate Meglumine / Q000494:pharmacology; D004338:Drug Combinations / Q000494:pharmacology; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects*; D006329:Heart Conduction System / Q000187:drug effects; D006801:Humans
D003287:Contrast Media; D004338:Drug Combinations; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; C027278:urovision