In vivo induction of sister-chromatid exchange in Umbra limi by the insecticides endrin, chlordane, diazinon and guthion.
Central mudminnows, Umbra limi, were exposed to the insecticides endrin, chlordane, diazinon and guthion at concentrations of 5.4 X 10(-12) M to 5.4 X 10(-9) M in the aquaria water. Endrin, chlordane and diazinon caused significant increase in the frequencies of SCE. The results of these tests in part are in contrast to previous work which did not find endrin to be mutagenic. Our results suggest that the in vivo SCE test is an efficacious method of detecting mutagenic pesticides in water.
D000818:Animals; D001387:Azinphosmethyl / Q000494:pharmacology; D002706:Chlordan / Q000494:pharmacology; D003434:Crossing Over, Genetic / Q000187:drug effects*; D003976:Diazinon / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004732:Endrin / Q000494:pharmacology; D005399:Fishes / Q000235:genetics*; D007306:Insecticides / Q000494:pharmacology*; D009153:Mutagens / Q000494:pharmacology; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D007306:Insecticides; D009153:Mutagens; D002706:Chlordan; D001387:Azinphosmethyl; D004732:Endrin; D003976:Diazinon