title: Echothiophate iodide cataracts in monkeys. Occurrence despite loss of accommodation induced by retrodisplacement of ciliary muscle.
abstract: Five cynomolgi underwent unilateral 360 degrees ciliary muscle retrodisplacement. Beginning several months later, they received 150 to 210 micrograms of echothiophate iodine topically once daily in both eyes for five months. In all eyes anterior and posterior subcapsular lens opacities developed that were characteristic of those caused by echothiophate. There were no apparent differences in biomicroscopic appearance or time course of the cataracts between eyes with or without retrodisplaced ciliary muscles. Since eyes with retrodisplaced ciliary muscles accommodate only minimally in response to echothiophate, possible mechanical stress on the lens due to sustained, intense accommodation cannot explain echothiophate cataractogenesis.
mesh_terms: D000065:Accommodation, Ocular; D000818:Animals; D002386:Cataract / Q000139:chemically induced* / Q000503:physiopathology; D002924:Ciliary Body / Q000502:physiology; D004456:Echothiophate Iodide / Q000009:adverse effects*; D005260:Female; D008252:Macaca fascicularis; D009130:Muscle, Smooth / Q000502:physiology
chemical_list: D004456:Echothiophate Iodide