Normal serum 25-hydroxyvitamin D levels in phenobarbital-treated toddlers.
Serum 25-hydroxyvitamin D (25-OHD) levels were measured in 74 children randomly treated in a double-blind fashion with either 5 phenobarbital/kg/day or placebo after a single febrile seizure. Phenobarbital treatment for a period from 5 to 12 months had no effect on the 25-OHD levels. However, both in the phenobarbital and the placebo groups, vitamin D supplementation raised the circulating 25-OHD concentration (p less than 0.05). Whether it has a protective effect remains thus to be seen.
D002112:Calcifediol / Q000097:blood*; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D010634:Phenobarbital / Q000494:pharmacology*
D002112:Calcifediol; D010634:Phenobarbital