In vitro and in vivo evaluation of two preparations of activated charcoal as adsorbents of aspirin.
1 The adsorptive capacities of two preparations of activated charcoal have been studied both in vitro and in vivo using aspirin as a test compound. 2 The in vitro adsorptive capacities of the charcoal preparations were 477 mg of acetylsalicylic acid/g effervescent charcoal ('Medicoal'); 359 mg/g untreated standard charcoal ('Norit-A') and 482 mg/g reheated charcoal ('Norit A'). 3 In vivo both charcoal preparations significantly reduced peak salicylate concentrations and salicylate availability, to a similar extent (analysis of variance P less than 0.001). 4 Both charcoal preparations have similar capacities for adsorbing aspirin both in vitro and in vivo.
D000327:Adsorption; D000328:Adult; D001241:Aspirin / Q000506:poisoning*; D001682:Biological Availability; D002606:Charcoal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D012459:Salicylates / Q000097:blood; D020156:Salicylic Acid; D013997:Time Factors
D012459:Salicylates; D002606:Charcoal; D020156:Salicylic Acid; D001241:Aspirin