Histochemical study of beta-glucuronidase in the rat uterus during implantation and pseudopregnancy.
On Day 5 of pregnancy and pseudopregnancy, beta-glucuronidase activity in pseudopregnant uteri and in the inter-implantation zones from pregnant animals was found mainly in stromal and glandular epithelial cells. The luminal epithelium also showed an intense enzyme-positive reaction, particularly in the apical regions of these cells. Blastocyst attachment was associated with marked depletion of beta-glucuronidase activity from epithelial cells lying adjacent to the blastocyst, suggesting a possible involvement of this lysosomal enzyme in the blastocyst-endometrium attachment reaction.
D000818:Animals; D010064:Embryo Implantation; D004717:Endometrium / Q000201:enzymology; D005260:Female; D005966:Glucuronidase / Q000032:analysis*; D006651:Histocytochemistry; D011247:Pregnancy; D011555:Pseudopregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000201:enzymology*
D005966:Glucuronidase