The lack of initiating and/or promoting activity of sodium malondialdehyde on SENCAR mouse skin.
Malondialdehyde (MDA), a lipid peroxidation product, has been implicated in carcinogenesis, in part for its reported mutagenic activity. It was of interest therefore, to determine its activity as either a complete carcinogen, a tumor initiator, or a tumor promoter. Using the SENCAR mouse skin model, pure sodium MDA (NaMDA) was found to lack activity in any of these categories. Furthermore, NaMDA was determined to be negative in the Chinese hamster V-79 metabolic cooperation assay for promoters.
D000818:Animals; D002277:Carcinoma / Q000139:chemically induced; D003043:Cocarcinogenesis; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D008297:Male; D008314:Malonates / Q000494:pharmacology*; D008315:Malondialdehyde / Q000494:pharmacology*; D051379:Mice; D009152:Mutagenicity Tests; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced; D012878:Skin Neoplasms / Q000139:chemically induced*
D008314:Malonates; D008315:Malondialdehyde