Methotrexate-induced necrolysis.
A 72-year-old woman with a long history of recalcitrant psoriasis developed severe generalized erosions after receiving low-dose (7.5 mg) methotrexate. Her clinical picture was consistent with toxic epidermal necrolysis and showed a gradual response to systemic steroids and topical therapy. Patients with underlying dermatoses or previous cutaneous insults may be particularly prone to adverse cutaneous reactions resulting from folic acid antagonists.
D000368:Aged; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D011565:Psoriasis / Q000188:drug therapy; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced* / Q000175:diagnosis
D008727:Methotrexate