Specific anti-influenza virus antibody production in vitro by lymphocytes from a subset of patients with hypogammaglobulinemia.
Specific anti-influenza virus antibody production in vitro was studied in peripheral blood mononuclear cells from 17 patients with hypogammaglobulinemia. Cells obtained from 6 of 12 patients with common variable hypogammaglobulinemia produced anti-influenza virus antibody, predominantly of the IgM isotype, when cultured in vitro with type A influenza virus. No antibody was produced in vitro, however, by cells from either of two patients with Bruton's type X-linked hypogammaglobulinemia or by cells from any of three patients with X-linked hypogammaglobulinemia and isolated growth hormone deficiency. These studies demonstrate that peripheral blood mononuclear cells from a subset of patients with common variable hypogammaglobulinemia retain the potential to produce specific antibody in response to antigenic stimulation.
D000328:Adult; D000361:Agammaglobulinemia / Q000235:genetics / Q000276:immunology*; D000368:Aged; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D004168:Diphtheria Toxoid / Q000276:immunology; D005260:Female; D006433:Hemocyanins; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D009980:Influenza A virus / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011043:Pokeweed Mitogens / Q000276:immunology; D013745:Tetanus Toxoid / Q000276:immunology; D014960:X Chromosome
D000914:Antibodies, Viral; D000941:Antigens; D004168:Diphtheria Toxoid; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011043:Pokeweed Mitogens; D013745:Tetanus Toxoid; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin