Hippocampal lesions increase the severity of unilaterally induced audiogenic seizures and decrease their latency.
The effect of unilateral and bilateral lesions of the hippocampus was examined in unilaterally tested SJL/J mice. The data indicate that lesions of the hippocampus decrease the latency to and increase the severity of audiogenic seizures.
D000161:Acoustic Stimulation; D000818:Animals; D006624:Hippocampus / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D012640:Seizures / Q000503:physiopathology*