Bone marrow genotoxicity of N-methyl, N-nitrosourea (NMU): n-alkanols as sister chromatid exchange (SCE) anti-inducers.
The in vivo SCE test was used to demonstrate significant inhibition of NMU bone marrow genotoxicity by pretreatment of Chinese hamsters with n-alkanols. Our findings exclude a loss of intracellular DNA alkylation potential through a competitive direct reaction of NMU with the weakly nucleophilic polar end of the n-alkanols, but not through methylations of nucleophilic membrane sites possibly liberated by structural modifications which the membrane-active amphiphilics induce.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D006224:Cricetinae; D003412:Cricetulus; D003434:Crossing Over, Genetic / Q000187:drug effects*; D004247:DNA / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005233:Fatty Alcohols / Q000494:pharmacology; D005796:Genes / Q000187:drug effects*; D008770:Methylnitrosourea / Q000037:antagonists & inhibitors / Q000633:toxicity*; D009607:Nitrosourea Compounds / Q000633:toxicity*; D000442:Octanols / Q000494:pharmacology; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013997:Time Factors
D005233:Fatty Alcohols; D009607:Nitrosourea Compounds; D000442:Octanols; D008770:Methylnitrosourea; C029383:n-decyl alcohol; D004247:DNA