Experimental evidence for biosynthesis of steroids in metastatic tissue originating from a primitive adrenocortical carcinoma.
1. Cortisol, cortisone, 11-deoxycortisol and deoxycorticosterone were synthesized in large amounts in vitro by a metastatic tissue from an adrenocortical carcinoma. 2. Both 11 beta- and 21-hydroxylase were very active. 3. A secreting metastasis can be thus responsible for a biological relapse. 4. A metastasis originating from another secreting adrenocortical carcinoma was found to be non-secreting.
D000306:Adrenal Cortex Neoplasms / Q000378:metabolism* / Q000628:therapy; D000328:Adult; D003348:Cortisone / Q000096:biosynthesis; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000096:biosynthesis; D009362:Neoplasm Metastasis; D013256:Steroids / Q000096:biosynthesis*
D013256:Steroids; D003348:Cortisone; D006854:Hydrocortisone