[Analysis of the prereplicative period of liver regeneration in young mice. The fate of the hepatocytes in the DNA synthesis phase at the moment of surgery].
In the liver of young mice after partial hepatectomy the hepatocytes which entered S-phase prior to the operation complete DNA synthesis in time and their major part is arrested in G2-phase. During the second half of lag-period (12-24 h after the operation) about half of these cells enters mitosis. Another half of the hepatocytes which were in S-phase during the operation does not proceed to mitosis. The structure of the nuclei of these latter suggests the regression of premitotic preparation: some nuclei return to the initial G0-structure of the normal heterosynthetic hepatocyte (endoreproduction cycle) and others preserve the premitotic structure characteristic of S-phase. A number of morphological features approaches this latter subpopulation to S-nuclei of tumour cells of the mouse hepatoma No. 46. A suggestion is put forward that this subpopulation has lost its capacity for heterosythesis due to operation liver trauma.
D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D004247:DNA / Q000096:biosynthesis*; D006498:Hepatectomy; D007399:Interphase; D008099:Liver / Q000166:cytology* / Q000378:metabolism; D008115:Liver Regeneration; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013997:Time Factors
D004247:DNA
Analiz prereplikativnogo perioda regeneratsii pecheni u molodykh mysheĭ. Sud'ba gepatotsitov, nakhodiashchikhsia v moment operatsii v faze sinteza DNK.