Hypophosphatemia induced by intravenous administration of Saccharated iron oxide.
Forty milligrams saccharated iron oxide was given intravenously, daily, to nine iron-deficient patients with moderate to severe anemia. During the 14-42 days of treatment, levels of serum inorganic phosphorus (Pi) decreased significantly and in a stepwise manner (before vs 1 week, P less than 0.005; 1 week vs 2 weeks, P less than 0.01). Seven of the nine patients became hypophosphatemic within 2 weeks and the other two within 4 weeks. In parallel with the decline in serum Pi, the phosphate clearance increased and tubular reabsorption of phosphate decreased. Reversion to normal levels was delayed in patients treated for the longer period.
D000747:Anemia, Hypochromic / Q000188:drug therapy; D005290:Ferric Compounds / Q000009:adverse effects*; D000077605:Ferric Oxide, Saccharated; D005937:Glucaric Acid; D006801:Humans; D007263:Infusions, Parenteral; D007408:Intestinal Absorption; D007501:Iron / Q000009:adverse effects*; D007668:Kidney / Q000378:metabolism; D010710:Phosphates / Q000097:blood*
D005290:Ferric Compounds; D010710:Phosphates; D007501:Iron; D000077605:Ferric Oxide, Saccharated; D005937:Glucaric Acid