Metabolism of safrole in the rat.
The urinary metabolites of safrole (4-allyl-1,2-methylenedioxybenzene) in the rat were identified using gas chromatographic - mass spectrometric methods. The amounts of the individual metabolites excreted were determined gas chromatographically. Metabolite excretion was 93% in 72 hrs and most of this material (86%) consisted of metabolites formed via demethylenation of the methylenedioxy moiety. The other metabolic routes observed were allylic hydroxylation and the epoxide-diol pathway.
D000818:Animals; D001711:Biotransformation; D003640:Dealkylation; D004149:Dioxoles / Q000378:metabolism*; D006900:Hydroxylation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012451:Safrole / Q000378:metabolism*
D004149:Dioxoles; D012451:Safrole