title: The late reaction following bronchial provocation with house dust mite allergen. Dependence on arachidonic acid metabolism.
abstract: The involvement of arachidonic acid metabolism in early and late bronchial reactions has been studied in four asthmatic subjects sensitive to Dermatophagoides pteronyssinus. Pre-treatment with either indomethacin (an inhibitor of the cyclo-oxygenase pathway) or benoxaprofen (an inhibitor of both cyclo-oxygenase and lipoxygenase pathways) failed to affect the amplitude, but did produce some foreshortening of the early response to allergen. If benoxaprofen is an effective inhibitor of SRS-A formation in vivo, then these observations question the role of SRS-A as a spasmogen in allergen-induced bronchospasm. Both drugs were effective inhibitors of the late reaction, implying involvement of cyclo-oxygenase products (endoperoxides, prostaglandins or thromboxanes) in the genesis of a late response to allergen.
mesh_terms: D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000276:immunology*; D001095:Arachidonic Acids / Q000378:metabolism*; D001249:Asthma / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D001985:Bronchial Provocation Tests; D001986:Bronchial Spasm / Q000517:prevention & control; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D008925:Mites / Q000276:immunology; D011422:Propionates / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000485:Allergens; D001095:Arachidonic Acids; D011422:Propionates; C011677:benoxaprofen; D007213:Indomethacin