Effects of 16,16-dimethyl-PGE2-methyl ester on aspirin- and indomethacin-induced gastric and intestinal lesions in mini pigs.
Aspirin, 100 mg/kg, given only twice at intervals of 16 h to fasted mini pigs induced lesions in the body but had no effect on the antrum and small intestine. Indomethacin, 40 mg/kg, given once daily for 10 consecutive days to non-fasted mini pigs very weakly irritated the pig stomach but induced multiple superficial lesions in the jejunum and ileum. 16,16-Dimethyl-PGE2-methyl ester, 10 micrograms/kg in two divided doses or 20 micrograms/kg in four divided doses for 10 days, markedly inhibited the aspirin- or indomethacin-induced gastric and intestinal lesions in mini pigs, respectively.
D015064:16,16-Dimethylprostaglandin E2 / Q000494:pharmacology*; D000818:Animals; D001241:Aspirin / Q000037:antagonists & inhibitors*; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000517:prevention & control*; D007213:Indomethacin / Q000037:antagonists & inhibitors*; D007422:Intestines / Q000187:drug effects*; D008297:Male; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects*; D013552:Swine; D013556:Swine, Miniature
D011459:Prostaglandins E, Synthetic; D015064:16,16-Dimethylprostaglandin E2; D001241:Aspirin; D007213:Indomethacin