A new relationship between air pollutant inhalation and cancer.
Many studies have been conducted to investigate the effects of different air pollutants on health. Our studies have focused on the effects of nitrogen dioxide (NO2), and recently we reported that inhalation of low levels of NO2 can facilitate cancer cell metastasis. The study described herein utilized the same B16 mouse melanoma metastasis model of previous investigations, but under different NO2 exposure conditions. The results provide further evidence that inhalation of ambient level NO2 (0.4 ppm) or polluted urban ambient air play a role in facilitation of blood-borne cancer cell metastasis. In addition, results show different patterns of melanoma cell distribution in the lungs of NO2- and ambient-air exposed animals. They also indicate that extended periods of clean air between NO2 exposures may diminish the severity of the insult in the less sensitive animals. It is our conclusion that the results provide strong support for the need of improved air quality and for reduction of noxious pollutants in urban ambient air.
D000393:Air Pollutants / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D008545:Melanoma / Q000139:chemically induced*; D008722:Methods; D051379:Mice; D008815:Mice, Inbred Strains; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009585:Nitrogen Dioxide / Q000008:administration & dosage / Q000633:toxicity*
D000393:Air Pollutants; D009585:Nitrogen Dioxide