Effects of repetitive doses of lithium in fluid-deprived rats.
Repetitive daily dosage (2.0 mEq/kg) of LiCl to rats maintained on a restricted fluid intake system resulted in cyclical increases and decreases in volume consumed on about a 10 day interval. At a higher dose (4.0 mEq/kg) a similar treatment led to death of the animals in 10 days. Both doses were associated with polyuria and weight loss.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D008094:Lithium / Q000009:adverse effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014868:Water Deprivation / Q000502:physiology*
D008094:Lithium