Changes in left ventricular ejection fraction after intracoronary thrombolytic therapy. Results of the Registry of the European Society of Cardiology.
Changes of left ventricular ejection fraction (delta EF) determined by monoplane contrast angiography before intracoronary streptokinase infusion and in the chronic stage of infarction before hospital discharge were assessed in 125 patients. Preintervention EF was .49 +/- .136 and chronic EF was .025 +/- .118 higher (p = .02) in the total group. Some subgroups had an improved EF: patients with collaterals (delta EF = .046 +/- .106, p less than .01, n = 42), patients with incomplete obstruction before intervention (delta EF = + .076 +/- .141, p = .03, n = 19) and patients in whom complete obstruction was permanently recanalized (delta EF = .024 +/- .113, p = .04, n = 89). A continuous model relating delta EF to both duration of infarct symptoms before hospital admission and to preintervention EF showed a decline in EF improvement over time in the subgroup that was admitted within less than 6 hours after the onset of chest pain and successfully recanalized (n = 72).
D002302:Cardiac Output / Q000187:drug effects*; D003097:Collateral Circulation; D003326:Coronary Circulation; D005343:Fibrinolytic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D013318:Stroke Volume / Q000187:drug effects*; D013997:Time Factors
D005343:Fibrinolytic Agents