DC-52, a novel antitumor antibiotic. 1. Taxonomy, fermentation and biological activity.
A novel antitumor antibiotic, DC-52 was found in the culture broths of Actinomycete DO-52. The producing organism was subsequently determined to be a new species and named Streptomyces melanovinaceus nov. sp. For the production of the antibiotic, soluble starch served as a good carbon source and soybean meal was a good nitrogen source tested. The antibiotic DC-52 is active against Bacillus subtilis, Staphylococcus aureus and Klebsiella pneumoniae, but not active against most Gram-negative bacteria. The antibiotic is also active against mouse leukemia P388.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005285:Fermentation; D007546:Isoquinolines / Q000096:biosynthesis / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D013302:Streptomyces / Q000145:classification* / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D007546:Isoquinolines; C038710:quinocarcin