Myoglobinuric renal failure due to drug-induced rhabdomyolysis.
1 Two cases of drug-induced rhabdomyolysis, one of them presenting with acute myoglobinuric renal failure are described. 2 The pathogenesis of rhabdomyolysis and renal failure in our cases is discussed with reference to work published by other authors. 3 Whereas there seems to be obvious evidence for direct toxic drug-muscle interaction, the mechanism for the development of myoglobinuric renal failure remains unclear.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D003402:Creatine Kinase / Q000097:blood; D003404:Creatinine / Q000097:blood; D004155:Diphenhydramine / Q000506:poisoning; D006801:Humans; D008297:Male; D009135:Muscular Diseases / Q000139:chemically induced* / Q000150:complications; D009212:Myoglobinuria / Q000139:chemically induced*; D010665:Phenylpropanolamine / Q000506:poisoning; D013997:Time Factors
C005331:norpseudoephedrine; D010665:Phenylpropanolamine; D004155:Diphenhydramine; D003404:Creatinine; D003402:Creatine Kinase