Inhibition by alcohols of the localization of radioactive nitrosonornicotine in sites of tumor formation.
Oral administration of ethanol, n-butanol, or t-butanol to mice 20 minutes before injection of carbon-14-labeled nitrosonornicotine inhibited the localization of radioactivity in bronchial and salivary duct epithelium and in the liver. Localization of radioactivity in the nasal epithelium and esophagus was not significantly reduced. These alcohols therefore may selectively inhibit tumor formation in three of the five sites where this carcinogen typically acts.
D020001:1-Butanol; D000428:Alcohol Drinking; D000438:Alcohols / Q000494:pharmacology*; D000818:Animals; D000440:Butanols / Q000494:pharmacology; D002273:Carcinogens / Q000037:antagonists & inhibitors*; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009369:Neoplasms / Q000139:chemically induced*; D009602:Nitrosamines / Q000494:pharmacology*; D012469:Salivary Glands / Q000187:drug effects; D012907:Smoking; D020002:tert-Butyl Alcohol
D000438:Alcohols; D000440:Butanols; D002273:Carcinogens; D009602:Nitrosamines; D000431:Ethanol; D020001:1-Butanol; D020002:tert-Butyl Alcohol; C008655:N'-nitrosonornicotine