Suppression of exploratory locomotor activity in the rat by the local application of 3-PPP enantiomers into the nucleus accumbens.
It was found that (-)-3-PPP, 5-160 microgram/side produced a statistically significant suppression of exploratory locomotor activity after application to the nucleus accumbens. The (+)-isomer was about 8 times less potent in suppressing exploratory activity. Except for suppression of the locomotor activity by 160 micrograms of (-)-3-PPP no statistically significant effects were produced by either isomer applied in the neostriatum.
D000818:Animals; D005106:Exploratory Behavior / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009714:Nucleus Accumbens / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D012686:Septal Nuclei / Q000187:drug effects*; D013237:Stereoisomerism
D010880:Piperidines; D011954:Receptors, Dopamine; C026539:preclamol