Cerebellar syndrome following neuroleptic induced heat stroke.
We report a patient in whom extreme hyperthermia, rhabdomyolysis, acute renal failure and a residual pancerebellar syndrome occurred while taking a combination of perphenazine and amitriptyline. We postulate that impaired thermoregulation due to psychotropic drugs was responsible for the development of heat stroke and that the cerebellar syndrome resulted directly from the elevated temperature.
D000639:Amitriptyline / Q000009:adverse effects; D001833:Body Temperature Regulation / Q000187:drug effects; D002524:Cerebellar Ataxia / Q000139:chemically induced*; D003975:Diazepam / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D006359:Heat Exhaustion / Q000139:chemically induced*; D006801:Humans; D008875:Middle Aged; D010546:Perphenazine / Q000009:adverse effects*
D000639:Amitriptyline; D010546:Perphenazine; D003975:Diazepam