Cimetidine in gastro-oesophageal reflux.
15-hour intra-oesophageal pH monitoring and symptom scores were used to compare the effect of cimetidine, 1 or 2 g daily with placebo on patients with acid gastro-oesophageal reflux. Night pain and antacid consumption were reduced by cimetidine, but other symptoms did not show significant differences. Symptomatic improvement appeared greater in smokers than non-smokers. 15-hour intra-oesophageal pH measurements showed that the number of reflux episodes was reduced in the cimetidine-treated groups.
D000328:Adult; D000368:Aged; D002927:Cimetidine / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000503:physiopathology; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012907:Smoking; D013997:Time Factors
D006146:Guanidines; D002927:Cimetidine