Pharmacokinetics of oral contraceptive steroids after morning or evening administration.
An oral contraceptive containing ethynyloestradiol and norethisterone was administered to six women in the morning and in the evening using a cross-over design. Serum levels of ethynyloestradiol and norethisterone were measured at various times after administration. There was no significant difference in a number of pharmacokinetic parameters between the two times of administration, suggesting that morning or evening administration of the contraceptive are equally effective.
D000328:Adult; D004359:Drug Therapy, Combination; D004997:Ethinyl Estradiol / Q000008:administration & dosage* / Q000097:blood; D005260:Female; D006801:Humans; D009640:Norethindrone / Q000008:administration & dosage* / Q000097:blood; D013997:Time Factors
D004997:Ethinyl Estradiol; D009640:Norethindrone