Ultrastructural localization of calcitonin in control and stimulated thyroid C cells of the rat using protein A-gold immunocytochemical technique.
Using anti-human calcitonin serum and a protein A - gold technique, calcitonin was localized at the ultrastructural level in control and calcium gluconate-stimulated thyroid C cells of the rat. In control rats calcitonin was detected within a majority of the secretory granules while in experimental animals it was demonstrated also within prosecretory granules present in Golgi apparatus.
D000818:Animals; D002116:Calcitonin / Q000032:analysis*; D002125:Calcium Gluconate / Q000494:pharmacology*; D003594:Cytoplasmic Granules / Q000032:analysis; D005942:Gluconates / Q000494:pharmacology*; D006046:Gold; D006056:Golgi Apparatus / Q000032:analysis; D051381:Rats; D013205:Staphylococcal Protein A; D013961:Thyroid Gland / Q000032:analysis* / Q000187:drug effects
D005942:Gluconates; D013205:Staphylococcal Protein A; D006046:Gold; D002116:Calcitonin; D002125:Calcium Gluconate