The effect of 1 alpha-hydroxycholecalciferol on the placental transfer of calcium and phosphate in sheep.
The calcium and phosphorus concentrations in foetal tissue or the placental transfer of 45Ca and 32P, or both, were studied in fifty-five control or 1 alpha-hydroxycholecalciferol (1 alpha-(OH)D3)-treated (0.1 micrograms/kg body-weight per d for 12 d) ewes between 77 and 140 d of gestation. Treatment resulted in a significant increase in the concentration of Ca and P in foetal tissues at all stages of gestation except at 140 d when, it is suggested, foetal mineralization may approach a maximum value. This increase in Ca and P concentration in foetal tissues was associated with an increased placental transfer of Ca, though at 111 and 120 d gestation this increase was not significant. P transfer, which was only measured at 140 d gestation, was also significantly higher in treated animals. The concentrations of Ca and P in both maternal and foetal plasma were increased significantly by the 1 alpha-(OH)D3 treatment. Whereas the concentration of Ca in the plasma of foetuses was always greater than in their dams, the concentration of plasma P in treated animals, unlike controls, was lower in foetuses than dams. This suggests that the increased placental transfer of P, unlike that of Ca, may be a passive rather than an active process.
D000818:Animals; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005333:Fetus / Q000378:metabolism; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D010758:Phosphorus / Q000097:blood / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D012756:Sheep
D006887:Hydroxycholecalciferols; D010758:Phosphorus; D002118:Calcium; C008088:alfacalcidol