Renal immunoblastic sarcoma complicating immunosuppressive therapy for Wegener granulomatosis.
A renal tumor developing in a patient receiving cyclophosphamide (Cytoxan) therapy for Wegener granulomatosis is reported. The tumor was similar histologically to the "immunoblastic" sarcoma that develops in renal allograft recipients as a complication of immunosuppressive therapy. This case report strengthens the cause and effect relationship between immunosuppressive drug usage and the subsequent development of neoplasia.
D000368:Aged; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy*; D006801:Humans; D007680:Kidney Neoplasms / Q000139:chemically induced*; D008223:Lymphoma / Q000139:chemically induced*; D011241:Prednisone / Q000008:administration & dosage
D003520:Cyclophosphamide; D011241:Prednisone