Continuous long-term insulin delivery in diabetic rats utilizing implanted osmotic minipumps.
Surgically implanted osmotic minipumps were used to continuously deliver insulin to chemically-induced diabetic rats. Serum glucose levels were maintained within normal limits for 7 days in all diabetic rats implanted with the minipumps. Beyond this time period, serum glucose levels could not be adequately controlled in greater than 50% of the diabetic rats. Seven of 20 diabetic rats originally implanted with osmotic minipumps were well controlled throughout the 31-day study period. This study demonstrates that insulin-filled osmotic minipumps provide no advantage over daily insulin injection in the long term control of diabetes.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005260:Female; D007332:Insulin Infusion Systems / Q000662:veterinary*; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose