title: Guinea pig maximization test: Podophyllum lignans.
abstract: The guinea pig maximization test was used to study the sensitizing potential of Podophyllum lignans; 0.5% of each drug in propylene glycol was used for induction and 0.01%, 0.05%, 0.1% and 0.5% preparations for topical challenge. The 0.1% and 0.5% preparations caused non-allergic toxic reactions associated with the cutaneous destructive influence of these drugs; allergic responses did not occur.
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D007509:Irritants; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000633:toxicity; D012882:Skin Tests
chemical_list: D007509:Irritants; D011034:Podophyllotoxin