title: The evolution of precision drug delivery.
abstract: Controlled-release formulations can enhance a drug's efficacy, safety, and duration of activity by regulating the rate and extent of drug release. 'Osmosin' (sodium indomethacin trihydrate) incorporates a newly developed osmotic system for oral administration. It is designed to release precisely a solution of drug at a predetermined rate into the gastro-intestinal lumen. Drug dissolution is programmed by the form itself and is independent of gastro-intestinal variables such as pH and motility. In vitro testing of this oral precision-release dosage form has been paralleled by a high degree of in vivo predictability. Certain drugs are better candidates for oral precision-release systems than others. Indomethacin is particularly well suited for incorporation into such a system. Comparisons with conventional drug forms have shown 'Osmosin' to produce more sustained and constant drug release profiles.
mesh_terms: D001682:Biological Availability; D003692:Delayed-Action Preparations; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000097:blood; D008297:Male; D009995:Osmosis; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism; D013678:Technology, Pharmaceutical
chemical_list: D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations; D007213:Indomethacin