Cytogenetic effects of quinoxaline-1,4-dioxide-type growth-promoting agents. II. Metaphase analysis in mice.
The clastogenicity of the growth-promoting agents, carbadox, olaquindox and cyadox, was examined by the metaphase analysis of chromosome aberrations in bone marrow of mice. The agents were administered by a stomach tube to male ICR mice 24 h before they were killed. Single-dose levels were 50, 100 and 200 mg/kg for carbadox; 200, 400, 600 and 800 mg/kg for olaquindox; and 400, 800 and 1200 mg/kg for cyadox. Carbadox was the most active; it induced chromosome aberrations even at a dose of 100 mg/kg. Olaquindox had about the same activity at a dose of 800 mg/kg. No chromosome-damaging effect of cyadox was observed even at a dose of 1200 mg/kg.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity; D001853:Bone Marrow / Q000187:drug effects / Q000502:physiology; D002218:Carbadox / Q000633:toxicity; D002869:Chromosome Aberrations; D008297:Male; D008677:Metaphase / Q000187:drug effects*; D051379:Mice; D008813:Mice, Inbred ICR; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D011810:Quinoxalines / Q000633:toxicity*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D009153:Mutagens; D011810:Quinoxalines; C020728:cyadox; C003282:quindoxin; C013168:olaquindox; D002218:Carbadox