1-[1-[2-[(3-Chlorobenzyl)oxy]phenyl]vinyl]-1H-imidazole hydrochloride, a new potent antifungal agent.
The synthesis and antifungal properties of 1-[1-[2-[(3-chlorobenzyl)oxy]phenyl]vinyl]-1H-imidazole hydrochloride (1 . HCl) are described. Topical application of cream and gel formulation of 1 . HCl showed high efficacy against guinea pig dermatophytosis.
D000287:Administration, Topical; D000818:Animals; D000935:Antifungal Agents; D003883:Arthrodermataceae / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D006168:Guinea Pigs; D007093:Imidazoles / Q000494:pharmacology*
D000935:Antifungal Agents; D007093:Imidazoles; C038008:croconazole