Vitamin K content of liver and feces from vitamin K-deficient and butylated hydroxytoluene (BHT)-treated male rats.
Vitamin K content of liver and feces from male rats fed diets containing butylated hydroxytoluene (BHT) was estimated by a chick bioassay method to investigate the mechanism of BHT-induced decreases in the activities of vitamin K-dependent clotting factors. The concentration of vitamin K in the liver of rats receiving BHT was reduced as compared to that of control rats. Conversely, the concentration of vitamin K in the feces from rats receiving BHT increased more than that from control rats. The vitamin K deficiency induced by BHT might be due to effects of BHT on absorption and excretion of vitamin K.
D000818:Animals; D001419:Bacteria / Q000378:metabolism; D002084:Butylated Hydroxytoluene / Q000633:toxicity*; D005243:Feces / Q000032:analysis*; D007413:Intestinal Mucosa / Q000378:metabolism; D008099:Liver / Q000032:analysis*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014812:Vitamin K / Q000032:analysis* / Q000378:metabolism; D014813:Vitamin K Deficiency / Q000378:metabolism*
D014812:Vitamin K; D002084:Butylated Hydroxytoluene