[Proteoglycan synthesis in the endothelium of embryonal vertebrate hearts: significance for the development of cardiovascular function].
The endothelium of the embryonic heart is able to synthetize proteoglycans (PG) as it is the myocardium. In the extracellular matrix, PG form highly polymeric visco-elastic networks, which besides others act as shock absorber. That is apparently of evidence for the modulation of embryonic heart actions. Because during the embryonic period the large arteries are simple endothelial tubes without having an elastic-muscular wall. That means the typical "windkessel" function such as dumping of pulse waves or a continues pressure distribution is not existent. The embryonic vessels are perfused like rigid tubes. The continuous rhythmic flow pattern in the endothelial tubes, necessary for perfusion of the different organs, is apparently compensated by a high initial pressure level initiated by the heart. It is concluded that the continuity of the pressure profile is caused by intracardial PG. The endothelial synthesis of the PG of the heart decreases with increasing development of the muscular wall of the vessels and disappears completely post partum.
D000818:Animals; D002642:Chick Embryo; D004727:Endothelium / Q000378:metabolism; D005260:Female; D005865:Gestational Age; D006321:Heart / Q000196:embryology*; D006439:Hemodynamics; D006801:Humans; D051379:Mice; D009131:Muscle, Smooth, Vascular / Q000196:embryology; D009206:Myocardium / Q000378:metabolism; D011247:Pregnancy; D011509:Proteoglycans / Q000378:metabolism*; D014982:Xenopus laevis
D011509:Proteoglycans
Proteoglycansynthese des Endothels im embryonalen Wirbeltierherzen: Bedeutung für die Entwicklung von Herz- und Kreislauffunktion.