Restoration of functional continuity in dystrophic murine muscle after crushing.
The recovery of functional continuity after crush injury was measured by a simple electrophsiological technique in semitendinosus muscles of normal and dystrophic mice of the C57BL/6J(dy2Jdy2J) strain. In contrast to virtually complete restitution in normal muscles, only one-third of fibers regained continuity in dystrophic muscles. The study also confirmed the lower resting membrane potentials of dystrophic fibers and the presence of "functional" denervation in some of them.
D000818:Animals; D051379:Mice; D008810:Mice, Inbred C57BL; D009121:Muscle Denervation; D009132:Muscles / Q000503:physiopathology*; D009137:Muscular Dystrophy, Animal / Q000503:physiopathology*; D012038:Regeneration