Malignant Clara cell line derived from ethylnitrosourea-induced murine lung adenomas.
Lung adenoma induced in Swiss-Webster mice by transplacental exposure to ethylnitrosourea were minced, cultured and carried as cell lines for up to 2 years. The evolution of cell lines was followed every 3 months by ability to grow in nude mice and by morphological and ultrastructural examination of the tumors. Four cell lines, each originating from a single cell inoculum, were cloned. One of these produced mainly papillary tumors in nude mice and ultrastructurally had the morphology of Clara cells.
D000236:Adenoma / Q000139:chemically induced*; D000818:Animals; D002460:Cell Line; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D008431:Maternal-Fetal Exchange; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D010212:Papilloma / Q000209:etiology / Q000648:ultrastructure*; D011247:Pregnancy