title: [Has current adjuvant cytostatic therapy in radically operated breast cancer patients failed?].
abstract: Ten years ago the first adjuvant study with combination chemotherapy for radically mastectomized mammary carcinoma patients was implemented. The results today show that 12 months' treatment with cyclophosphamide, methotrexate and 5-fluorouracil does not prolong survival. In the group of premenopausal women with 1 to 3 histologically positive axillary lymph nodes a lengthening of the time to relapse was observed (in 20% of the patients), but with no prolongation of survival. In the light of these results the ongoing Swiss trials should be reevaluated.
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000628:therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008408:Mastectomy; D011379:Prognosis
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Hat die heutige adjuvante zytostatische Therapie bei radikal operierten Mammakarzinom-Patientinnen versagt?