Opioid and non-opioid mechanisms of footshock-induced analgesia: role of the spinal dorsolateral funiculus.
Exposure to inescapable footshock causes either an opioid or non-opioid mediated analgesia in the rat depending on the temporal parameters of its administration. Lesions of the spinal dorsolateral funiculus significantly reduce both the opioid and non-opioid forms of this footshock-induced analgesia. Thus, these two neurochemically discrete pain-inhibitory systems appear to depend on the integrity of the same descending path, one known to be activated by morphine and by analgesic brain stimulation.
D000698:Analgesia; D000818:Animals; D004597:Electroshock; D005121:Extremities / Q000294:innervation; D007839:Functional Laterality; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000502:physiology*; D013312:Stress, Physiological / Q000503:physiopathology*
D009020:Morphine