Impaired Myelination in rats given excess vitamin A postnatally.
The effect of postnatal administration of 1000 I.U. of Vitamin A on 4th, 6th, 8th, and 10th day of age to rat pups has been studied on brain myelin lipid and sulphatide synthesis from Na235SO4. Administration of vitamin A reduced brain weight, free cholesterol, phosphatidal ethanolamine and the synthesis of myelin sulphatides from Na235SO4.
D000818:Animals; D001921:Brain / Q000254:growth & development* / Q000473:pathology; D001923:Brain Chemistry; D002784:Cholesterol / Q000032:analysis; D005260:Female; D006130:Growth Disorders / Q000139:chemically induced*; D006986:Hypervitaminosis A; D008055:Lipids / Q000032:analysis*; D008297:Male; D009186:Myelin Sheath / Q000254:growth & development*; D009929:Organ Size / Q000187:drug effects; D010743:Phospholipids / Q000032:analysis; D011247:Pregnancy; D051381:Rats; D013433:Sulfoglycosphingolipids / Q000096:biosynthesis
D008055:Lipids; D010743:Phospholipids; D013433:Sulfoglycosphingolipids; D002784:Cholesterol