Myocardial infarct size from serum cardiac myosin light chain. Clinical and experimental studies.
The relationship between myocardial infarct size and serum cardiac light chain (LC) levels was studied in experimental and clinical myocardial infarction. In dogs with left anterior descending coronary artery occlusion, regression analysis showed good correlation between infarct size and LC II release, but CPK-MB release failed to correlate with infarct size because of a decreasing value of cumulative CPK with larger sized infarctions. In patients with acute myocardial infarction, Peak LC I levels correlated well with CPK release, since the phenomenon of the decreased CPK release in larger sized infarction was not so distinctive in human cases. Thus, LC determination may better quantitate the extent of myocardial damage as well as provide a specific and sensitive method for diagnosis of acute myocardial infarction.
D000818:Animals; D003402:Creatine Kinase / Q000097:blood*; D004285:Dogs; D006801:Humans; D009203:Myocardial Infarction / Q000473:pathology*; D009218:Myosins / Q000097:blood*; D011863:Radioimmunoassay
D003402:Creatine Kinase; D009218:Myosins