[Pharmacologic evaluation of penicillin in children with meningococcal meningitis].
Levels of penicillin both in blood and CSF are determined in 11 children with meningococcal meningitis. Authors compare these values with MIC. The therapeutic pattern was 500.000 Ul/Kg/day of benzylpenicillin, in six doses, with a single initial doses of 200.000 Ul/Kg. The results recommend not to use a lower doses in order to assure a permanently efficient penicillin concentration.
D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008585:Meningitis, Meningococcal / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D010400:Penicillin G / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D013997:Time Factors
D002556:Cerebrospinal Fluid Proteins; D010400:Penicillin G
Evaluación farmacológica de la penicilina en niños con meningitis meningocócica.