A remotely operated pump for intracerebral micro-injection in the primate.
A method is described for making small (2-6 microliters) localized intracerebral drug injections in the conscious monkey. A base plate and guide cannula are initially secured to the skull under general anaesthesia. A mechanical pump containing the drug solution and fitted with an injection needle is located on the base plate assembly. In the conscious animal the pump is triggered magnetically to deliver a predetermined volume into the target brain region.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D008845:Microinjections / Q000295:instrumentation*; D009048:Motor Skills / Q000187:drug effects; D009482:Neurophysiology / Q000295:instrumentation*; D010215:Papio