[Effect of substances altering the metabolism of endogenous serotonin on mitotic activity in the regenerating liver of mice].
The serotonin (S) precursor 5-hydroxytryptophan and MAO inhibitor o-chlorpargyline injected alone or combined increase the endogenous S level in the regenerating liver and stimulate mitotic activity. The tryptophan hydroxylase inhibitor p-chlorophenylalanine and reserpine decrease both the endogenous S level and the mitotic index (MI). There is a close correlation between the endogenous S level and the MI.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006498:Hepatectomy; D008115:Liver Regeneration / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008938:Mitosis / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors
D012701:Serotonin
Vliianie veshchestv, izmeniaiushchikh obmen éndogennogo serotonina, na mitoticheskuiu aktivnost' v regeneriruiushcheĭ pecheni mysheĭ.