Effect on haemostasis of intravenous injection of alpha 2-antiplasmin in cats treated with streptokinase.
The effect in cats of an intravenous injection of purified human alpha 2-antiplasmin on changes in the haemostatic system, caused by administration of streptokinase was investigated. The decrease in fibrinogen and plasminogen caused by streptokinase infusion was immediately inhibited by the alpha 2-antiplasmin infusion. The increase in vascular permeability and the prolongation of coagulation times were efficiently inhibited.
D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D002199:Capillary Permeability / Q000187:drug effects; D002415:Cats; D005260:Female; D006487:Hemostasis / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D010314:Partial Thromboplastin Time; D012709:Serum Albumin / Q000378:metabolism; D013300:Streptokinase / Q000494:pharmacology*; D000979:alpha-2-Antiplasmin / Q000494:pharmacology*
D001798:Blood Proteins; D012709:Serum Albumin; D000979:alpha-2-Antiplasmin; D013300:Streptokinase