A large cathepsin D-derived fragment from the central part of the fibronectin subunit chains.
A mild cathepsin D digest of fibronectin only contained single-chain peptides of 200, 140 and 70 kDa and double-chain fragments of about 300 and 140 kDa containing the C-terminal disulfide link. Among the single-chain fragments the 200 kDa peptide was a precursor of the 140 kDa and 70 kDa peptides. The latter was correlated to the N-terminal and the former to the central region of the fibronectin subunit chains.
D002402:Cathepsin D; D002403:Cathepsins; D055598:Chemical Phenomena; D002621:Chemistry; D005353:Fibronectins / Q000032:analysis*; D006801:Humans; D010446:Peptide Fragments / Q000302:isolation & purification*
D005353:Fibronectins; D010446:Peptide Fragments; D002403:Cathepsins; D002402:Cathepsin D