1,3-Diaryltriazenes: a new class of anorectic agents.
A series of substituted 1,3-diaryltriazenes has been synthesized and tested for anorectic activity. Several members of the series were effective; one compound, 1,3-bis[2-cyano-5-(trifluoromethyl)phenyl]triazene, was particularly active, causing weight loss in rats, dogs, and squirrel monkeys. It was devoid of overt central nervous system activity, and compared to previously reported biologically active triazenes, it was relatively nontoxic up to 30 days of drug administration.
D000818:Animals; D001067:Appetite Depressants / Q000138:chemical synthesis; D001835:Body Weight / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D004435:Eating / Q000187:drug effects; D005277:Fenfluramine / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012453:Saimiri; D013329:Structure-Activity Relationship; D014226:Triazenes / Q000138:chemical synthesis* / Q000494:pharmacology
D001067:Appetite Depressants; D014226:Triazenes; D005277:Fenfluramine; C038160:1,3-bis(2-cyano-5-(trifluoromethyl)phenyl)triazene; D003913:Dextroamphetamine