Potential oxidative pathways of catecholamines in the formation of lipid peroxides and genesis of heart disease.
Effects of vitamin E, a fat soluble antioxidant, on the isoproterenol-induced changes in the lipid peroxide activity as determined by a quantitation of malondialdehyde (MDA) content in the myocardium were examined. Isoproterenol treatment (80 mg/kg given over two days in two equal doses) caused more than 100 percent increase in the MDA content which was prevented by pretreatment of the animals with vitamin E (alpha-tocopherol acetate, 10 mg/kg) for two weeks. Animals maintained on vitamin E deficient diet for 8 weeks were found to be more sensitive to isoproterenol-induced increase in the MDA content. A small increase in MDA content was also seen due to vitamin E deficiency alone. These changes were found to be reversible upon a 2 week feeding of the animals on the normal diet coupled with vitamin E treatment. Based on these data it is proposed that free radical mediated increase in lipid peroxide activity may have a role in catecholamine-induced heart disease.
D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D009202:Cardiomyopathies / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism*; D007545:Isoproterenol / Q000008:administration & dosage; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D009206:Myocardium / Q000648:ultrastructure; D010101:Oxygen Consumption; D010725:Phosphocreatine / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000008:administration & dosage
D002395:Catecholamines; D008054:Lipid Peroxides; D010725:Phosphocreatine; D014810:Vitamin E; D008315:Malondialdehyde; D000255:Adenosine Triphosphate; D007545:Isoproterenol