title: An inverse relationship between serum immunoglobulin-G and intellectual functioning.
abstract: Serum immunoglobulin levels for IgA, IgE, IgG, and IgM were measured in 13 institutionalized, profoundly mentally retarded individuals and for 20 retarded and 29 intellectually average noninstitutionalized individuals. A significant elevation in IgG was observed for the retarded groups as compared with the intellectually average group. There was a significant inverse relationship between IgG and level of intellectual functioning. The elevated IgG is suggestive of the findings with auto-immune diseases and warrants further investigation.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008607:Intellectual Disability / Q000276:immunology*; D007360:Intelligence; D008297:Male
chemical_list: D007074:Immunoglobulin G