Perfluorocarbon enhancement of heterologous red cell survival: a reticuloendothelial block effect?
The intravascular survival of human erythrocytes transfused to primate animals was prolonged by infusing the recipients with a perfluorocarbon red cell substitute (Fluosol DA). This effect is probably due to transient block of the animals' reticuloendothelial system by the perfluorocarbon emulsion. Perfluorocarbon compounds could be used to study the role of reticuloendothelial function in the immune destruction of red cells.
D000818:Animals; D002860:Chromium Radioisotopes; D004338:Drug Combinations / Q000494:pharmacology; D004905:Erythrocyte Aging / Q000187:drug effects*; D005466:Fluorocarbons / Q000494:pharmacology*; D006895:Hydroxyethyl Starch Derivatives; D012157:Mononuclear Phagocyte System / Q000502:physiology*; D002679:Pan troglodytes; D010215:Papio
D002860:Chromium Radioisotopes; D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination