[Dependence of the frequency of radiation-induced iso-labels on the colchicine concentration].
In experiments on human lymphocytes it was demonstrated that the frequency of iso-labels induced by irradiation of cells at the G2 phase decreases with increasing concentration of colchicine used for accumulation of metaphases. This might be explained by the possible influence of colchicine on the pattern of chromosome replication.
D001345:Autoradiography; D002478:Cells, Cultured; D002877:Chromosomes, Human / Q000187:drug effects / Q000528:radiation effects*; D003078:Colchicine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D007399:Interphase / Q000187:drug effects / Q000528:radiation effects; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects
D003078:Colchicine
Zavisimost' chastoty izometok, vyzvannykh oblucheniem, ot kontsentratsii kolkhitsina.