Redox delivery system for brain-specific, sustained release of dopamine.
Dopamine was transformed into a redox chemical system for delivery to the brain. The lipoidal form allowed penetration of the blood-brain barrier. Oxidative and hydrolytic processes then transformed the delivery form into a quaternary ammonium precursor of dopamine. The quaternary ammonium precursor was rapidly eliminated from the general circulation, whereas that formed in the brain was locked in, thereby providing a significant and sustained brain-specific dopaminergic activity.
D000818:Animals; D001058:Apomorphine / Q000378:metabolism; D001812:Blood-Brain Barrier; D001923:Brain Chemistry; D003692:Delayed-Action Preparations; D004298:Dopamine / Q000008:administration & dosage* / Q000032:analysis / Q000378:metabolism; D005260:Female; D008297:Male; D010084:Oxidation-Reduction; D011388:Prolactin / Q000097:blood; D051381:Rats
D003692:Delayed-Action Preparations; D011388:Prolactin; D001058:Apomorphine; D004298:Dopamine