title: Activity of brodimoprim and metioprim alone and in combination with sulfonamides against anaerobic bacteria.
abstract: The activities of the 2,4-diamino-5-benzylpyrimidines brodimoprim and metioprim against anaerobic bacteria were tested alone and in combination with sulfonamides. Alone they were two to four times more active than trimethoprim, but in combination with sulfonamides, their activity was slightly lower than that of trimethoprim plus sulfamethoxazole.
mesh_terms: D000693:Anaerobiosis; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004338:Drug Combinations; D008826:Microbial Sensitivity Tests; D013449:Sulfonamides / Q000494:pharmacology*; D014295:Trimethoprim / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D013449:Sulfonamides; D014295:Trimethoprim; C036263:metioprim; C037079:brodimoprim