[Changes in water-sodium balance in patients with hypertension subjected to different types of hypotensive therapy].
The parameters of water-electrolyte metabolism and central hemodynamics were studied in 44 patients with essential hypertension (stage II-III) after 3-week treatment with sympatholytics and diuretics. Patients with hyperkinetic type of hemocirculation had a sodium lack at the stage of stable hypertension, therefore the diuretic treatment is not indicated for such patients. The treatment with the diuretic oxodolin was accompanied by the decrease in the peripheral resistance of blood vessels, in sodium metabolism and its extracellular fraction, and by the increase of the deposit sodium fraction. The elevation of the renin-angiotensin system activity due to the diuretic therapy did not influence the blood pressure level and the central hemodynamics parameters.
D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood; D000803:Angiotensin I / Q000097:blood; D002752:Chlorthalidone / Q000627:therapeutic use; D005110:Extracellular Space / Q000378:metabolism; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism*; D007741:Labetalol / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D000450:Aldosterone; D000803:Angiotensin I; D012964:Sodium; D002752:Chlorthalidone; D007741:Labetalol; D011188:Potassium
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