Fasting and ketogenic diet effects on audiogenic seizures susceptibility of magnesium deficient rats.
Because fasting and ketogenic diets decrease seizure susceptibility in epileptics, their anticonvulsant effects were studied using sound-induced seizures in the magnesium-deficient rat. Fasting markedly depressed seizure incidence and severity but did not affect latency (sec to seizure onset). High-fat diet increased incidence of audiogenic seizures and seizure severity, and decreased latency. Gavage of medium chain triglyceride, beta-hydroxybutyrate or glucose did not affect seizure incidence, seizure severity or latency. Nonspecific excitability level was not associated with treatment nor with seizure incidence, severity or latency time.
D000161:Acoustic Stimulation; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology; D005215:Fasting; D005260:Female; D007657:Ketone Bodies / Q000378:metabolism*; D008274:Magnesium; D008275:Magnesium Deficiency; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000209:etiology*
D004041:Dietary Fats; D007657:Ketone Bodies; D008274:Magnesium