[Effect of cyproheptadine on the ultrastructure of the neurons of the arcuate nucleus in the hypothalamus of the rat].
The data are presented on changes in the rat arcuate nuclear neuron ultrastructure after using cyproheptadine (peritol, Egyt Pharmaceutical Works, Hungary) in a water suspension at a dose of 20 mg/kg once daily during 7 successive days and twice a day within 10 days. It was shown that cyproheptadine decreases the functional activity of the arcuate nuclear neurons, depending on the total amount of the drug used. Cyproheptadine-induced inhibition of the forming neurohormone release from neurons is likely to be one of the mechanisms of its therapeutic effect in Itsenko-Cushing's disease.
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000187:drug effects* / Q000648:ultrastructure; D003533:Cyproheptadine / Q000494:pharmacology*; D003864:Depression, Chemical; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains
D003533:Cyproheptadine
Vliianie tsiprogeptadina na ul'trastrukturu neĭronov arkuatnogo iadra gioptalamusa krys.