Tumor induction by a single subcutaneous injection of 1-butyl-1-nitrosourea or 1-butylurea in newborn mice.
A subcutaneous injection of 1-butyl-1-nitrosourea (BNU) at the maximum tolerated dose (333 mg/kg body wt.) to newborn CDF1 mice induced adenocarcinoma and adenoma of the lung, adenoma of the liver, thymic or non-thymic lymphoma and neurinoma of the acusticus nerve; the total incidence of tumors was statistically significant as compared with that of control. However, in the 1-butylurea (BU) mice, one adenoma of the lung was induced in a male mouse; the total incidence of tumor was comparable to that of control.
D000230:Adenocarcinoma / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D000831:Animals, Newborn; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D007279:Injections, Subcutaneous; D008113:Liver Neoplasms / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008223:Lymphoma / Q000139:chemically induced; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced*; D009464:Neuroma, Acoustic / Q000139:chemically induced; D009607:Nitrosourea Compounds / Q000633:toxicity*; D013953:Thymus Neoplasms / Q000139:chemically induced; D014508:Urea / Q000031:analogs & derivatives* / Q000633:toxicity
D002273:Carcinogens; D009607:Nitrosourea Compounds; C002738:N-nitrosobutylurea; D014508:Urea; C006865:butylurea