[Light transmittance and light-protective action of containers for phenylalkylamine solutions. 84: Contributions to problems concerning the use of plastic containers for liquid pharmaceutical preparations; 18: Stability of drugs and preparations].
Using glass as a comparison material, the authors determined spectrophotometrically the light transmittance of plastic containers of different composition and evaluated their ability to protect phenylalkylamine solutions against ultraviolet irradiation. The material best suitable for these solutions is low-density polyethylene coloured with 0.05% of pigment orange G. Brown glass, which meets all requirements as to the protection from light, favours the degradation of phenylalkylamines as it releases heavy metal ions.
D000588:Amines / Q000528:radiation effects*; D004349:Drug Packaging; D004355:Drug Stability; D008027:Light; D010969:Plastics; D013056:Spectrophotometry, Ultraviolet
D000588:Amines; D010969:Plastics
Lichtdurchlässigkeit und Lichtschutzwirkung von Behältnissen für Phenylalkylaminlösungen. 84. Mitteilung: Beiträge zur Problematik des Einsatzes von Kunststoffbehältern für flüssige Arzneizubereitungen; 18. Mitteilung: Stabilität von Arzneistoffen und Zubereitungen.