Toxicity of methyldopa (Aldomet) to mouse neuroblastoma cells in vivo.
The adrenergic blocking agent methyldopa (Aldomet) is toxic to C-1300 neuroblastoma cells in vivo. Four injections of Aldomet at a dose of 7.5 mg/injection were given over a period of 24 hr to C-1300 neuroblastoma-bearing mice. This treatment killed a significant proportion of the C-1300 neuroblastoma cells. Flow cytometric data suggest that sensitivity of tumor cells to Aldomet is not related to the cell cycle.
D000818:Animals; D002453:Cell Cycle; D002470:Cell Survival / Q000187:drug effects; D003851:Deoxyribonucleases / Q000378:metabolism; D005434:Flow Cytometry; D008297:Male; D008750:Methyldopa / Q000633:toxicity*; D051379:Mice; D009447:Neuroblastoma / Q000473:pathology*; D014357:Trypsin / Q000378:metabolism
D008750:Methyldopa; D003851:Deoxyribonucleases; D014357:Trypsin