[The state of the epidermis and the morphometric evaluation of epithelial cells in nevi and skin melanomas].
9 nevi and 11 melanomas, identified in accordance with present-day classifications, were examined. The histological and morphometric peculiarities of epithelium in the growth zone of these lesions and adjacent areas were studied. A significant correlation was established between histological and biochemical indexes, on the one hand, and the biological characteristics of melanocyte proliferation, on the other. Hyperplastic processes in melanoma and adjacent zone were matched by a marked increase in the cell size (2.5-5 times that in nevus). Deep submerged epithelial vegetations in melanoma form the basis for tumor cell proliferation and subsequent invasion; hence, they may be regarded as possible pathway of tumor progression. This morphogenetic peculiarity should be taken into account in identification of melanoma and determination of tendencies of its growth.
D004817:Epidermis / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D006984:Hypertrophy; D008544:Melanocytes / Q000473:pathology; D008545:Melanoma / Q000473:pathology*; D009506:Nevus / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*
Sostoianie épidermisa i morfometricheskaia otsenka epitelial'nykh kletok v nevusakh i melanomakh kozhi.