Effects of feeding on the systemic clearance of indocyanine green and propranolol blood concentrations and plasma binding.
In six healthy subjects a 250 g steak significantly increased the systemic clearance of indocyanine green. During a steady-state infusion of propranolol there was a rapid decrease (mean 35%) in blood propranolol concentrations within 5 min of feeding and levels were reduced for 30 min before gradually returning towards the pre-feeding. These results suggest that the systemic clearance of high extraction drugs may be increased immediately following food.
D000328:Adult; D004044:Dietary Proteins / Q000494:pharmacology; D004435:Eating; D006801:Humans; D007208:Indocyanine Green / Q000378:metabolism*; D007263:Infusions, Parenteral; D008297:Male; D008657:Metabolic Clearance Rate; D011433:Propranolol / Q000008:administration & dosage / Q000097:blood*; D011485:Protein Binding
D004044:Dietary Proteins; D011433:Propranolol; D007208:Indocyanine Green