title: Caffeine: effects on the behaviors of juvenile rats.
abstract: Caffeine, a central nervous system stimulant, was found to alter the expression of 3 behaviors in the juvenile rat. After caffeine administration, locomotor activity was increased in rats of all ages studied (24-84 days old). Pinning, a behavior characteristic of the juvenile period and used as an index of play-fighting, was suppressed following caffeine exposure, but only in rats 24-54 days old. Social investigation was not affected by caffeine in 24- and 34-day-old rats. However, in animals 44-84 days of age caffeine increased both the frequency and duration of investigation of a novel juvenile. Although caffeine influenced all the behaviors we observed, the developmental time course of caffeine's effects was different for each behavior.
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002110:Caffeine / Q000633:toxicity*; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012919:Social Behavior; D012934:Social Isolation; D014886:Weaning
chemical_list: D002110:Caffeine