title: Hapten, carrier recognition and response by immunocytes of the primitive vertebrate, Notophthalmus viridescens.
abstract: These experiments were designed to test whether newt (Notophthalmus viridescens) immunocytes are able to recognize the hapten, 2,4,6-trinitrophenyl (TNP), separately from a heterologous erythrocyte (RBC) carrier. While a single priming injection with an erythrocyte species which is unrelated to the carrier of the TNP fails to stimulate amplification of the anti-TNP response, sequential (2X) priming provides about 50% as much amplification as a single priming injection of RBC homologous with the carrier. The anti-carrier response is not increased by sequential priming with the unrelated RBC. Moreover, sequential priming with RBC homologous with the carrier species initiates a suppression of the anti-hapten response without affecting anti-carrier activity levels. Thus the recognition and regulation of responses to a hapten and its carrier may be unlinked in this species.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D002352:Carrier Proteins / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology*; D006241:Haptens / Q000276:immunology; D009578:Nitrobenzenes / Q000276:immunology*; D009673:Notophthalmus viridescens / Q000276:immunology*; D012455:Salamandridae / Q000276:immunology*; D013154:Spleen / Q000166:cytology / Q000276:immunology*; D014301:Trinitrobenzenes / Q000276:immunology*
chemical_list: D002352:Carrier Proteins; D006241:Haptens; D009578:Nitrobenzenes; D014301:Trinitrobenzenes