[Effect of estradiol and testosterone, administered in the neonatal period, on the hypothalamo-hypophyseal-gonadal interrelations and fertility of the male rat].
The influence of neonatal single subcutaneous injections of different testosterone propionate doses was studied comparatively to estradiol benzoate action on different parameters of genital function. Estradiol injections exert more pronounced injurious effect versus testosterone treatment, producing a decrease in luliberin, LH, testosterone synthesis and release, as well as a fall of the genital mass, resulting in 100% sterility of the animals.
D000818:Animals; D000831:Animals, Newborn; D004958:Estradiol / Q000008:administration & dosage* / Q000009:adverse effects; D005500:Follow-Up Studies; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000503:physiopathology*; D007248:Infertility, Male / Q000139:chemically induced*; D008297:Male; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000503:physiopathology*; D013739:Testosterone / Q000008:administration & dosage* / Q000009:adverse effects
D013739:Testosterone; D004958:Estradiol
Vliianie neonatal'nogo vvedeniia éstradiola i testosterona na gipotalamo-gipofizarno-gonadnye vzaimootnosheniia i plodovitost u samtsov krys.