Brain 5-hydroxytryptamine and learned resistance to punishment.
Rats can learn to persist in making a response that is punished. Brain 5-hydroxytryptamine (5-HT) systems are known to mediate acute responding to punishment. This work investigates 5-HT involvement in learned resistance to punishment. Forebrain 5-HT was depleted by intracerebral injection of 5,7-dihydroxytryptamine. Lesioned rats were fully able to learn resistance to punishment, although acute responding to punishment was impaired. Forebrain 5-HT does not mediate learned resistance to punishment.
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D003891:Desipramine / Q000494:pharmacology; D004597:Electroshock; D006185:Habituation, Psychophysiologic / Q000502:physiology*; D006624:Hippocampus / Q000187:drug effects; D008297:Male; D009042:Motivation / Q000502:physiology*; D009434:Neural Pathways / Q000187:drug effects; D011903:Raphe Nuclei / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012688:Septum Pellucidum / Q000187:drug effects; D012701:Serotonin / Q000502:physiology*; D013681:Tegmentum Mesencephali / Q000187:drug effects
D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D003891:Desipramine