Temperate phage induction and filament formation in Vibrio cholerae by furazolidone.
Furazolidone a synthetic nitrofuran used in the treatment of cholera, was found to cause prophage induction and filament formation in Vibrio cholerae. Maximum induction of phage beta was obtained at a drug concentration of 0.5 microgram/ml. Neither induction of prophage nor filamentation took place if the drug treatment was carried out in the presence of 2.5 micrograms/ml chloramphenicol, indicating a requirement for de novo protein synthesis. Our results strongly suggest the existence of "SOS" type functions in Vibrio cholerae.
D002701:Chloramphenicol / Q000494:pharmacology; D005664:Furazolidone / Q000494:pharmacology*; D014734:Vibrio cholerae / Q000187:drug effects* / Q000648:ultrastructure; D014775:Virus Activation / Q000187:drug effects*
D005664:Furazolidone; D002701:Chloramphenicol