Antithyroid effect of chlorpropamide?
1 The relationship between plasma chlorpropamide concentration and thyroid function was examined in 87 maturity onset diabetic patients receiving chronic therapy. 2 Although plasma chlorpropamide concentration was weakly negatively correlated with serum thyroxine (r = 0.33, P less than 0.01) the mean serum thyroxine and thyrotrophin (TSH) were not different from that of a matched control group of diabetics treated with diet alone. 3 Serum thyroxine was negatively correlated with the duration of diabetes in both groups. 4 These results suggest that chlorpropamide does not have a clinically significant antithyroid effect.
D000328:Adult; D000368:Aged; D002747:Chlorpropamide / Q000009:adverse effects* / Q000097:blood; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000187:drug effects*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
D013972:Thyrotropin; D013974:Thyroxine; D002747:Chlorpropamide