Chemotherapy of chemically-induced colorectal tumours.
Benign and malignant tumours were induced in the large bowel of rats by the carcinogen 1,2-dimethylhydrazine (DMH). Benign tumours appeared from week 20 onwards and malignant tumours from week 30. 5-Fluorouracil was administered intraperitoneally in maximally tolerated doses from week 26 onwards and failed to influence significantly the development of either benign or malignant tumours. Tumours induced by DMH are a close model of human colorectal cancer and suitable for testing anticancer drugs. Agents with greater activity against colorectal cancer are required.
D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D004127:Dimethylhydrazines; D004195:Disease Models, Animal; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D011919:Rats, Inbred Strains; D012004:Rectal Neoplasms / Q000139:chemically induced / Q000188:drug therapy*
D004127:Dimethylhydrazines; D005472:Fluorouracil