Effects of dipyridamole (Persantin R) on morphology and motility of mouse embryo cells.
DPD inactivates the edges of cultured mouse embryo cells. Pseudopodal activity is inhibited and spreading is reduced. Concomitantly, the growth rate of the cells is reduced. The interference reflection image shows very large close contacts under DPD treated cells. The translocation speed of the cells is unaffected. DPD penetrates into the cytoplasm, but less or not into the nucleus.
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects*; D002465:Cell Movement / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003593:Cytoplasm / Q000378:metabolism; D004176:Dipyridamole / Q000378:metabolism / Q000494:pharmacology*; D004622:Embryo, Mammalian; D051379:Mice; D011554:Pseudopodia / Q000187:drug effects*
D004176:Dipyridamole