Establishment of slowly growing lung tumor cell model by aspiration of tumor cells.
In male BDF1 mice, aspiration of suspended Lewis lung tumor cells at a certain concentration leads to the occurrence of lung carcinomas after 30 days. Under the chosen experimental conditions tumor incidence is about 70%. Within 20 days, animals die from this slowly growing tumor. Furthermore, the experimental conception offers a model which seems suitable for investigations into growth regulation of lung tumors.
D000818:Animals; D001239:Inhalation; D008175:Lung Neoplasms / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000503:physiopathology; D012119:Respiration