The distribution and interaction of haemoglobin variants and the beta thalassaemia gene in Liberia.
In a population survey in Liberia, West Africa, 12 major tribes were examined for the prevalence of Hb S, Hb C, and the beta thalassaemia (beta Thal) gene. Hb C is rare; Hb S and beta Thal occur in polymorphic frequencies. The distribution of both genes shows an inverse correlation. The beta Thal trait was diagnosed by quantitation of Hb A2 on DE 52-microchromatography. This method proved to be reliable and useful for mass screening.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D006441:Hemoglobin A / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D007988:Liberia; D008297:Male; D008875:Middle Aged; D013789:Thalassemia / Q000235:genetics*
D006455:Hemoglobins, Abnormal; D006441:Hemoglobin A