[Effect of cAMP accumulation activators on the individual stages of genome expression in cells in acute radiation injury. 6. Inhibition of RNA synthesis on a template of isolated chromatin by separate histone fractions from the liver of normal, irradiated and serotonin-protected rats].
Using an acellular system, with isolated chromatin as a template, and E. coli RNA-polymerase it was shown that irradiation of rats with a lethal dose (7.76 Gy) caused a progressing, in time, decrease in the inhibitory effect of H1, H2a, H2b, H3 and H4 histones (particularly H2a histone) on RNA synthesis. The administration of serotonin prior to irradiation diminished considerably this effect of radiation.
D000818:Animals; D002474:Cell-Free System; D006657:Histones / Q000235:genetics; D008099:Liver / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000235:genetics* / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D012701:Serotonin / Q000627:therapeutic use*; D014158:Transcription, Genetic / Q000187:drug effects / Q000528:radiation effects*
D006657:Histones; D011837:Radiation-Protective Agents; D012701:Serotonin
Vliianie aktivatorov nakopleniia tsAMF na otdel'nye étapy ékspressii genoma v kletkakh pri ostrom luchevom porazhenii organizma. Soobshchenie 6. Ob osobennostiakh ingibirovaniia sinteza RNK na matritse izolirovannogo khromatina otdel'nymi fraktsiiami gistonov iz pecheni normal'nykh, obluchennykh i zashchishchennykh serotoninom krys.