Effect of N-acetylserotonin on the serum level of thyroid-stimulating hormone in the male rat.
The effect of N-acetylserotonin (NAS) on serum levels of thyroid-stimulating hormone (TSH) in the male rat was investigated. In the first experiment, NAS and carrier were injected intraperitoneally into rats. The animals were sacrificed 30 and 60 min after injection. It was found that NAS (100 micrograms/rat) significantly depressed serum TSH 60 Min after injection when compared with saline-injected controls. In another experiment in which samples were obtained from rats at 0, 30, 60, 90 and 120 min after injection, significant decrease in serum TSH was observed at all time intervals after NAS (100 micrograms/rat) injection while no such difference was observed in the saline-injected groups. It is suggested that NAS may exert an inhibitory effect on TSH secretion.
D000818:Animals; D008297:Male; D008550:Melatonin / Q000096:biosynthesis / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D013972:Thyrotropin / Q000097:blood*
D012701:Serotonin; D013972:Thyrotropin; D008550:Melatonin; C006389:N-acetylserotonin