title: [Radioprotective action of a gas hypoxic mixture GHM-10 in multiple irradiations of rat and human skin].
abstract: Gas hypoxic mixture (GHM-10) decreased significantly the occurrence and duration of radioepidermitis after local therapeutic fractionated irradiation of Wistar rat skin with a cumulative dose of 66 Gy. In patients subjected to radiation therapy and protected with GHM-10 erythema and epidermitis developed at a much higher cumulative dose than in the controls. With erythema dose modifying coefficient was 1.38 +/- 0.06.
mesh_terms: D000818:Animals; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D004890:Erythema / Q000517:prevention & control; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D009584:Nitrogen / Q000008:administration & dosage*; D010100:Oxygen / Q000008:administration & dosage*; D010101:Oxygen Consumption / Q000528:radiation effects; D010313:Partial Pressure; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D011855:Radiodermatitis / Q000517:prevention & control; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000528:radiation effects*
chemical_list: D011837:Radiation-Protective Agents; D009584:Nitrogen; D010100:Oxygen
vernacular_title: Izuchenie radiozashchitnogo deĭstviia gazovoĭ gipoksicheskoĭ smesi GGS-10 pri mnogokratnom obluchenii kozhnykh pokrovov krys i cheloveka.