Regulatory role of nucleotides, nucleosides and their deoxy derivatives on adenylate cyclase of Mycobacterium smegmatis.
Nucleotides, nucleosides and their deoxy derivatives inhibited adenylate cyclase activity in Mycobacterium smegmatis. Nucleosides with a triphosphate group were the most effective inhibitors. Amongst the deoxy derivatives, the cytidine derivatives were most inhibitory while deoxyadenosine and deoxyguanosine at 1 mM had no effect of the enzyme.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D009161:Mycobacterium / Q000187:drug effects* / Q000201:enzymology; D009705:Nucleosides / Q000494:pharmacology*; D009711:Nucleotides / Q000494:pharmacology*
D009705:Nucleosides; D009711:Nucleotides; D000262:Adenylyl Cyclases