title: Sex differences in the phenotypic expression of avian dystrophy.
abstract: Although the gene for muscular dystrophy in chickens is not sex-linked, results from clinical tests suggest that it is expressed differently in males and females. As measurement of muscle contractile responses provides a quantitative index for the severity of the disease, the contractile properties of the extensor digitorum communis muscle were examined in normal and dystrophic chickens with respect to sex. Furthermore, these differences were examined in young (6 to 9 weeks) and old (greater than 6 months) chickens. Results showed that age-related sex differences were apparent for those mechanical parameters of the muscle (in particular the posttetanic potentiation and posttetanic contracture) known to distinguish normal and dystrophic birds. The sex differences observed in the younger group indicate that the female birds were more severely affected by the disease than were the male. In the older group, the male were affected by the disease more severely than age-matched female birds. If the inheritance pattern is truly autosomal then it is likely that one or more developmental factors interact with the dystrophic genotype and alter the dystrophic phenotype.
mesh_terms: D000818:Animals; D002645:Chickens / Q000235:genetics*; D005260:Female; D008297:Male; D009132:Muscles / Q000473:pathology*; D009137:Muscular Dystrophy, Animal / Q000235:genetics* / Q000473:pathology; D010641:Phenotype; D012737:Sex Factors