Influence of vitamin A on the formation of ethylnitrosourea (ENU)-induced leukemias.
In mice, administration of ethylnitrosourea (120 mg/kg body weight) on day 14 of pregnancy leads to a transplacentally induced and transplantable leukemia in a high percentage of the offspring. Moreover, 100% of the offspring develop, later on, adenomas of the lung. Application of retinol palmitate (daily dose 170,000 IU/kg) reduces leukemogenesis up to 50%, yet without influencing formation of lung adenomas.
D000236:Adenoma / Q000139:chemically induced / Q000503:physiopathology; D000375:Aging; D000818:Animals; D004224:Diterpenes; D005038:Ethylnitrosourea / Q000633:toxicity*; D005260:Female; D007942:Leukemia, Experimental / Q000139:chemically induced* / Q000503:physiopathology; D008175:Lung Neoplasms / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000503:physiopathology; D009607:Nitrosourea Compounds / Q000633:toxicity*; D011247:Pregnancy; D000084562:Retinyl Esters; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology
D004224:Diterpenes; D009607:Nitrosourea Compounds; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate; D005038:Ethylnitrosourea