Inhibition and recovery of DNA synthesis in PHA-stimulated u.v.-irradiated lymphocytes from patients with actinic keratosis.
The recovery, after inhibition by u.v.-irradiation, of phytohaemagglutinin-stimulated DNA synthesis is impaired in lymphocytes from patients with multiple actinic keratoses (AK) compared to the recovery in lymphocytes from age-matched, control individuals. This shows that the reduced level (50%) of DNA repair activity in AK cells is sufficiently different from that in normal cells to significantly affect cellular activity.
D004260:DNA Repair; D006801:Humans; D007642:Keratosis / Q000235:genetics*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000502:physiology; D010835:Phytohemagglutinins; D014466:Ultraviolet Rays
D010835:Phytohemagglutinins