Receptivity disorders in gonadal dysgeneses. i. Klinefelter's syndrome.
Long-term variation (21-30 days) in the gonadotropic hormones level and testosterone was followed up in Klinefelter's syndrome (chromatine positive). Clinically, the authors followed up the development of the androgen-dependent target tissues before and after administration of 400 mg testosterone/month for 6 months. It was also found a fluctuation in the gonadotropic hormones secretion on a 21-30-day trial which differs from that of the normal adult male. We noticed a great variability of the androgen-dependent structures development in one and the same subject or in different subjects, and a low response to the action of big and prolonged doses of testosterone. The authors interpret these findings as a decrease in the sensitivity of the androgen-dependent target structures (hypothalamus and peripheral tissues) induced genetically and fundamenting the concept of the existence of a receptivity pathology.
D000293:Adolescent; D000328:Adult; D005260:Female; D006059:Gonadal Dysgenesis; D006062:Gonadotropins / Q000378:metabolism*; D006065:Gonadotropins, Pituitary / Q000378:metabolism*; D006801:Humans; D007713:Klinefelter Syndrome; D008297:Male; D011944:Receptors, Androgen / Q000032:analysis; D013739:Testosterone / Q000378:metabolism* / Q000627:therapeutic use
D006062:Gonadotropins; D006065:Gonadotropins, Pituitary; D011944:Receptors, Androgen; D013739:Testosterone