Accumulation of D-aspartic acid with age in the human brain.
An age-related accumulation of D-aspartic acid was detected in the white matter of ten normal brains from individuals aged 30 to 80 years. Gray matter showed no systematic increase in D-aspartic acid. The rate constant for D-aspartate formation in the brain is equal to the predicted value calculated for 37 degrees C. Accumulation of the uncommon D-aspartate isomer in myelinated white matter implies that there is little or no turnover of this tissue, and this may have a bearing on dysfunction of the aging brain or on other diseases of myelin.
D000328:Adult; D000368:Aged; D000375:Aging; D001224:Aspartic Acid / Q000032:analysis* / Q000502:physiology; D001923:Brain Chemistry; D005136:Eye Proteins / Q000032:analysis; D006801:Humans; D007907:Lens Nucleus, Crystalline / Q000032:analysis; D008875:Middle Aged
D005136:Eye Proteins; D001224:Aspartic Acid