title: Effects of ion-containing liposomes upon the chemoafferent activity of the rabbit carotid body superfused in vitro.
abstract: The effects of calcium concentration changes in carotid body cells on the chemoreceptor discharges were studied in vitro on carotid bodies removed from anaesthetized rabbits. Addition of calcium-containing liposomes to the superfusing medium increased the chemoreceptors' discharges. This effect was abolished by hyperoxia or when EGTA-containing liposomes were simultaneously added with the calcium-containing liposomes. A histological control with ferritin-enriched liposomes showed that the liposome content was transferred into the cellular elements of the preparation except the nerve endings. Results suggest a relationship between calcium concentration changes in carotid body cells and chemoafferent activity.
mesh_terms: D000818:Animals; D002344:Carotid Body / Q000187:drug effects* / Q000648:ultrastructure; D002628:Chemoreceptor Cells / Q000187:drug effects*; D004594:Electrophysiology; D005293:Ferritins; D066298:In Vitro Techniques; D008081:Liposomes / Q000494:pharmacology*; D008722:Methods; D008854:Microscopy, Electron; D010477:Perfusion; D011817:Rabbits
chemical_list: D008081:Liposomes; D005293:Ferritins