Streptococcal antibodies and complement components in tropical post-streptococcal glomerulonephritis.
Anti-deoxyribonuclease "B' was elevated in 94.9% of 59 cases of post-streptococcal glomerulonephritis studied, whereas ASO was elevated only in 54.4% of cases showing that the ADNB titre is a more sensitive indicator of antecedent streptococcal infection than ASO, in tropical countries with a high prevalence of pyoderma. Serum C3c (beta 1A) levels were significantly decreased, especially in the early phase of the illness and returned to normal with remission. C4 levels were decreased only in the early phase of the illness, suggesting involvement of the alternate pathway subsequent to classical pathway activation.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis*; D000989:Antistreptolysin / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000032:analysis*; D015932:Complement C3c; D003181:Complement C4 / Q000032:analysis*; D003851:Deoxyribonucleases / Q000276:immunology; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013290:Streptococcal Infections / Q000150:complications / Q000276:immunology*; D013291:Streptococcus / Q000276:immunology*; D014329:Tropical Climate
D000907:Antibodies, Bacterial; D003176:Complement C3; D003181:Complement C4; D015932:Complement C3c; D000989:Antistreptolysin; D003851:Deoxyribonucleases