title: The occurrence of an adverse reaction to chloroquine in Dirofilaria immitis-infected dogs.
abstract: The occurrence of an adverse reaction in Dirofilaria immitis-infected dogs following an intramuscular injection of chloroquine is described. The manifestations of this adverse reaction were characteristic of a neurologic disorder rather than the hypovolemic, shock-like state of the post-DEC adverse reaction previously described in dogs. In 3 of the 12 dogs the adverse reaction was of sufficient severity as to be fatal. Alterations in serum fibrinogen, serum transaminase levels and platelet numbers occurred but the magnitude of changes were not as great as that in the post-DEC adverse reaction. Following the injection of chloroquine the microfilaremia increased to a degree that was greater than the increase following DEC administration in the dog.
mesh_terms: D000818:Animals; D002738:Chloroquine / Q000009:adverse effects* / Q000627:therapeutic use; D004183:Dirofilaria immitis / Q000502:physiology; D004184:Dirofilariasis / Q000188:drug therapy*; D004285:Dogs / Q000469:parasitology; D004660:Encephalitis / Q000139:chemically induced
chemical_list: D002738:Chloroquine