title: Renal blood flow alterations after temporary ischemia. An experimental model in the rabbit.
abstract: In an effort to investigate the efficiency of various pharmacological agents in protecting the kidney against normothermic ischemia, an animal model was developed and the post-ischemic hemodynamics in the renal cortex of rabbit kidneys were studied. Renal cortical blood flow was evaluated 5-30 min after 60 min of normothermic ischemia of the left kidney using 141Ce-, 51Cr-, and 85Sr-labelled microspheres. Control groups were subjected to sham operation. The right kidneys served as individual controls. Ischemic kidneys showed a significant weight increase independent of reperfusion. Furthermore, a transient highly significant increase of cortical blood flow was found with an absolute maximum about 10 min after termination of ischemia. This increase in cortical blood flow was paralleled by a highly significant decrease of vascular resistance.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D007511:Ischemia / Q000503:physiopathology*; D007672:Kidney Cortex / Q000098:blood supply*; D011817:Rabbits; D012079:Renal Circulation; D014655:Vascular Resistance