Salicylate and mitochondrial injury in Reye's syndrome.
Electron microscopic and spectrophotometric studies showed that salicylate causes gross swelling of mitochondria in isotonic salt solutions. In overall morphology the salicylate-treated mitochondria resembled those from patients with Reye's syndrome. Salicylate analogs such as m-hydroxybenzoate, p-hydroxybenzoate, and benzoate did not exert this effect. The mitochondria deformed by salicylate tended to return to their original condensed form on removal of the drug.
D000818:Animals; D001565:Benzoates / Q000494:pharmacology; D019817:Benzoic Acid; D062385:Hydroxybenzoates / Q000494:pharmacology; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000648:ultrastructure; D008933:Mitochondrial Swelling / Q000187:drug effects; D010226:Parabens; D051381:Rats; D012202:Reye Syndrome / Q000139:chemically induced*; D012459:Salicylates / Q000009:adverse effects* / Q000494:pharmacology
D001565:Benzoates; D062385:Hydroxybenzoates; D010226:Parabens; D012459:Salicylates; C032948:3-hydroxybenzoic acid; D019817:Benzoic Acid; C038193:4-hydroxybenzoic acid