Postnatally induced formation of the corpus callosum in acallosal mice on glia-coated cellulose bridges.
Developing axons of the corpus callosum of mice are guided across the cerebral midline by a slinglike glial structure that forms transiently between the hemispheres. If the "sling" is cut at precallosal stages, the would-be callosal fibers whirl into paired neuromas adjacent to the longitudinal cerebral fissure. In experiments on such surgically acallosal animals, the aberrant commissural axons maintained a potential to regrow across the hemispheres at prenatal and early postnatal stages if they were presented with a properly aligned, glia-covered scaffold spanning the hemispheres.
D000818:Animals; D001369:Axons / Q000502:physiology; D001921:Brain / Q000196:embryology / Q000502:physiology; D002482:Cellulose; D003337:Corpus Callosum / Q000196:embryology / Q000254:growth & development*; D004622:Embryo, Mammalian / Q000502:physiology; D005333:Fetus / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009457:Neuroglia / Q000502:physiology
D002482:Cellulose