Bioavailability of sustained-release theophylline granules in apple sauce in pediatric asthmatic patients.
To facilitate administration of sustained-release theophylline in pediatric patients fourteen children with asthma were studied using intact capsules versus the granular contents in apple sauce. In a cross-over study during multiple dose intervals the effectiveness of this administration technique was demonstrated for maintaining bioavailability and sustained-release characteristics.
D001249:Asthma / Q000188:drug therapy*; D001682:Biological Availability; D002648:Child; D003692:Delayed-Action Preparations; D005260:Female; D005638:Fruit; D006801:Humans; D008297:Male; D013806:Theophylline / Q000008:administration & dosage* / Q000378:metabolism
D003692:Delayed-Action Preparations; D013806:Theophylline