The zoapatle V--the effect of kauradienoic acid upon uterine contractility.
Kauradienoic acid was obtained from the hexanic extract of M. tomentosa (Cerv) leaves by chromatographic separation. This substance influenced the in vitro contractility of the rat, dog and guinea pig uterine strips. It also induced strong contractions of the guinea pig uterus in vivo when administered intravenously, without changes on arterial blood pressure. The effects produced by the plant infusion, the hexanic extract and pure species were compared. The hexanic of other utero-active compounds in M. tomentosa in addition to those already described is discussed.
D000818:Animals; D004224:Diterpenes / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006168:Guinea Pigs; D035924:Montanoa; D010082:Oxepins / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D014590:Uterine Contraction / Q000187:drug effects*
D004224:Diterpenes; D010082:Oxepins; D010936:Plant Extracts; C014576:grandiflorenic acid