Radionuclide kinetics in MIRD dose calculations.
A recent case report is reviewed and an alternative model for the radionuclide kinetics is presented; it estimates in an absorbed dose differing by a factor of two from the published calculation. Both models are consistent with observed data. Within a compartment model, one may choose to monitor a compartment of interest directly, or to monitor another compartment and (indirectly) solve for the activity in the compartment of interest. Advantages and disadvantages are reviewed.
D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000378:metabolism; D007700:Kinetics; D008168:Lung / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008954:Models, Biological; D011829:Radiation Dosage; D011877:Radionuclide Imaging; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging
D007457:Iodine Radioisotopes