Alcohol self-administration disrupts reproductive function in female macaque monkeys.
Female macaque monkeys self-administered high doses of alcohol (2.9 to 4.4 grams per kilogram per day) for 3 to 6 1/2 months. Amenorrhea, atrophy of the uterus, decreased ovarian mass, and significant depression of luteinizing hormone levels were associated with chronic alcohol intoxication. Reproductive system failure in female primates following self-induced dependence on alcohol parallels the results of clinical studies of alcoholic women.
D000437:Alcoholism / Q000503:physiopathology*; D000568:Amenorrhea / Q000139:chemically induced; D000818:Animals; D000431:Ethanol / Q000009:adverse effects; D005260:Female; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008251:Macaca; D008598:Menstruation / Q000187:drug effects; D010053:Ovary / Q000187:drug effects; D010903:Pituitary Gland, Anterior / Q000187:drug effects; D012098:Reproduction / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects
D000431:Ethanol; D007986:Luteinizing Hormone