The production of abnormal cells and Reed-Sternberg-like cells from normal lymphocytes.
D002478:Cells, Cultured; D006644:Histiocytes / Q000473:pathology*; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000473:pathology*