Phospholipid composition of liver in rats fed high levels of 13-cis retinoic acid.
The composition of liver phospholipids was studied in rats fed for 4 weeks diets containing 0, 100 or 300 mg 13-cis retinoic acid per kg diet. There was a significant decrease in phosphatidylcholine content, whereas the levels of phosphatidylethanolamine were slightly increased in liver phospholipids of rats fed 13-cis retinoic acid. The fatty acid composition of total phospholipids, PC, PE, and P1 + PS fractions revealed a general increase in the levels of 18:2 and 20:3 omega 6, whereas the levels of 20:4 omega 6 and C22 fatty acids were reduced in most of the hepatic phospholipids isolated from rats fed 13-cis retinoic acid containing diets. A decrease in the double-bond index of fatty acids was also observed in phospholipids of rats fed 13-cis retinoic acid. The data suggest that high levels of 13-cis retinoic acid may possibly be influencing the activities of microsomal desaturating and chain-elongating enzymes in the liver.
D000818:Animals; D004032:Diet; D005227:Fatty Acids / Q000032:analysis; D008099:Liver / Q000032:analysis* / Q000187:drug effects; D008297:Male; D010743:Phospholipids / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D014212:Tretinoin / Q000008:administration & dosage* / Q000494:pharmacology
D005227:Fatty Acids; D010743:Phospholipids; D014212:Tretinoin