Enhanced 5-hydroxytryptamine sensitivity of morphologically differentiated neuroblastoma cells.
The addition of 2% (vol./vol.) dimethyl sulfoxide to replated confluent cultures of NIE-115 neuroblastoma cells abolishes cell-proliferation and induces extensive neurite formation. The morphologically differentiated cells exhibit higher resting membrane potential and higher input resistance. In addition the differentiated cells also express an increased sensitivity to 5-hydroxytryptamine.
D000818:Animals; D002454:Cell Differentiation; D002460:Cell Line; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D009447:Neuroblastoma; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology*
D012701:Serotonin; D004121:Dimethyl Sulfoxide