Hb Albany-GA or alpha 2(11)(A9)Lys leads to Asn beta 2.
A fast-moving alpha chain abnormal hemoglobin (Hb J) was observed in a black teenager from southern Georgia. Its quantity, i.e. the sum of Hb J and Hb J2, was 23.8%. Its presence did not cause any hematological or clinical abnormalities. Tryptic peptides from a digest of the alpha-J chain were separated by HPLC. Amino acid analysis of these peptides and sequence analysis of the abnormal T-2,3 nonapeptide identified a Lys leads to Asn substitution at position alpha 11(A9).
D000293:Adolescent; D000596:Amino Acids / Q000032:analysis; D055598:Chemical Phenomena; D002621:Chemistry; D002848:Chromatography, DEAE-Cellulose; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004592:Electrophoresis, Starch Gel; D005260:Female; D006448:Hemoglobin J / Q000032:analysis; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006801:Humans; D014357:Trypsin
D000596:Amino Acids; D006455:Hemoglobins, Abnormal; D006448:Hemoglobin J; C038622:hemoglobin Albany Georgia; D014357:Trypsin