Effects of ethanol on after--discharges evoked by electrical stimulation of hippocampus in rabbits.
The influence of ethyl alcohol on the after-discharges provoked by electrical stimulation of dorsal hippocampus in rabbits was studied. The after-discharges were registered from frontal cortex reticular mesencephalic substance and contralateral hippocampus. The hippocampus was stimulated seven times every 30 min. in two sessions performed in a 7 days' interval. In the second session ethanol in doses 0.8 g/kg i.v. and 0.4 g/kg p. o. and i. v. was administered. Ethanol administered intravenously in a small dose increase, whereas in a larger dose prevented the increase of after-discharge duration during the session. The influence of ethanol on after-discharges correlated with its initial blood concentration.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004569:Electroencephalography; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007696:Kindling, Neurologic / Q000187:drug effects; D008297:Male; D011817:Rabbits; D012154:Reticular Formation / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
D000431:Ethanol