Retarded development of XO conceptuses during early pregnancy in the mouse.
The growth and development of XO and XX mice were compared from 7 1/4 to 18 1/2 days of gestation. The 7 1/4-day XO egg cylinders were retarded in development (and consequently small) when compared with XX egg cylinders, and this lag in development remained until 10 1/2 days. By 12 1/4 days there was a considerable degree of 'catch-up', but this was not fully maintained. A subgroup of very severely retarded XO fetuses were preferentially located near the cervix. The placentas of XO fetuses were of normal size until 18 1/2 days when they were significantly larger than those of XX controls.
D000782:Aneuploidy; D000818:Animals; D001724:Birth Weight; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics / Q000502:physiology*; D011247:Pregnancy