[Effect of tumor antigens on receptors of T-and B-lymphocytes in patients with cancer of the stomach].
The effect of tumor antigens and those of gastric mucosa on rosette-formation by T-lymphocytes of blood and sheep red blood cells was studied in 65 gastric cancer patients by means of a spontaneous E-rosette-formation variation test. Antigens of original tumor extracts stimulated rosette-formation in 55.4% of patients, more frequently in cases of stage I-II tumors than in those of stage IV. After antigens of normal mucosa were removed from tumor extracts the frequency of positive tests did not change significantly in gastric cancer group, whereas, in controls, it dropped from 26.4 to 7.5%. Tumor antigens tested did not produce the same effect on the rosette-formation by B-lymphocytes with mouse red blood cells.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D005753:Gastric Mucosa / Q000276:immunology; D006801:Humans; D051379:Mice / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D012397:Rosette Formation; D012756:Sheep / Q000276:immunology; D013274:Stomach Neoplasms / Q000276:immunology*
D000951:Antigens, Neoplasm; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell
Vliianie antigenov opukholeĭ na retseptory T- i B-limfotsitov bol'nykh rakom zheludka.