[Mechanism of proteinuria: filtration and resorption of plasma proteins].
Glomerular filtration and tubular reabsorption of endogenous serum proteins were measured using micropuncture technique in the rat kidney. Data resulting from experiments on the single nephron level are compared with human overall kidney function. Reabsorption of filtered protein was virtually complete (84 to 96%) at endogenous serum levels. Tubular reabsorption capacity is almost reached under control conditions. In human infants, tubular protein reabsorption capacity increases with maturation.
D000042:Absorption; D000419:Albuminuria / Q000378:metabolism; D000818:Animals; D001797:Blood Protein Electrophoresis; D001798:Blood Proteins / Q000378:metabolism*; D005919:Glomerular Filtration Rate; D006801:Humans; D007231:Infant, Newborn; D007684:Kidney Tubules / Q000378:metabolism; D008297:Male; D008970:Molecular Weight; D009399:Nephrons / Q000378:metabolism; D011507:Proteinuria / Q000503:physiopathology* / Q000652:urine; D051381:Rats
D001798:Blood Proteins
Mechanismus der Proteinurie: Filtration und Resorption von Plasma-Eiweissen.