Mexiletine in the treatment of recurrent ventricular tachycardia. Prediction of long-term arrhythmia suppression from acute and short-term response.
Acute intravenous and short-term oral mexiletine therapy was effective in suppressing the arrhythmia in six of eight patients with recurrent ventricular tachycardia. Five of the six patients who were placed on maintenance therapy remained asymptomatic during a mean follow-up of 15 months. The study shows that the acute and short-term suppression of ventricular tachycardia by mexiletine can be a useful predictor of its long-term efficacy.
D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008801:Mexiletine / Q000009:adverse effects / Q000627:therapeutic use*; D011437:Propylamines / Q000627:therapeutic use*; D012008:Recurrence; D013610:Tachycardia / Q000188:drug therapy*
D011437:Propylamines; D008801:Mexiletine