Taste aversions to several halogenated hydrocarbons.
Five halogenated hydrocarbons (chloral; trichloroethylene; 1,2-dichloroethylene; 1,2-dichloroethane and 1,1,2-trichloroethane) were evaluated in the taste aversion paradigm to determine thresholds for producing aversion effects. Comparisons were made between threshold determination for acute and repetitive conditioning trials. All of the compounds produced saccharin aversions following one pairing of the chemical exposure with saccharin ingestion. Repetitive conditioning trials did not alter the thresholds for producing aversions with any of the five compounds evaluated. Potencies of the compounds in producing conditioned taste aversions were chloral greater than 1,1,2-trichloroethane greater than 1,2-dichloroethane greater than 1,2-dichloroethylene greater than trichloroethylene.
D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects; D004000:Dichloroethylenes / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D006846:Hydrocarbons, Halogenated / Q000633:toxicity*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012439:Saccharin; D013649:Taste / Q000187:drug effects*; D014241:Trichloroethylene / Q000633:toxicity
D004000:Dichloroethylenes; D006846:Hydrocarbons, Halogenated; D014241:Trichloroethylene; D012439:Saccharin