Relationship between chemical structure and allergenicity: aromatic amines.
This review utilizes current clinical and experimental contact sensitization data with aromatic amines to hypothesize on the relationship between chemical structure and allergenicity. The available data suggests: 1. A Primary amino group in the ring induces sensitizing properties; 2. aromatic amine allergenicity is related to basicity, resulting from the action of substituents in the ring; 3. electron donor substituents enhance whereas electron acceptor substituents attenuate the activity.
D000485:Allergens / Q000494:pharmacology*; D000588:Amines / Q000009:adverse effects*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003877:Dermatitis, Contact / Q000209:etiology; D006801:Humans; D010655:Phenylenediamines / Q000009:adverse effects; D011506:Proteins / Q000378:metabolism; D012867:Skin / Q000378:metabolism; D013329:Structure-Activity Relationship
D000485:Allergens; D000588:Amines; D010655:Phenylenediamines; D011506:Proteins