Homogeneously staining regions and tumorigenicity.
A homogeneously staining region (HSR), a chromosome abnormality associated with gene amplification, was found to increase in length coincident with an enhancement in tumorigenicity when cells from a human retinoblastoma cell line were serially passaged in athymic (nu/nu) mice.
D000818:Animals; D002460:Cell Line; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000235:genetics; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002900:Chromosomes, Human, 1-3 / Q000648:ultrastructure*; D005134:Eye Neoplasms / Q000209:etiology / Q000235:genetics / Q000648:ultrastructure*; D005260:Female; D005784:Gene Amplification; D006801:Humans; D007621:Karyotyping; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D012175:Retinoblastoma / Q000209:etiology / Q000235:genetics / Q000648:ultrastructure*; D013997:Time Factors