The effect of leukotrienes C4 and D4 on microcirculatory flow in humans.
By quantifying the flare response, leukotrienes LTC4 and LTD4 were shown to increase the microcirculatory flow in a sigmoidal dose-response relation over the dose-range of 6.25-800 pmol. LTD4 was found to be more potent than LTC4 after 5 min, but not after 15 min, as estimated by this method. Laser-Doppler flowmeter studies confirmed that LTD4 is a more potent vasodilator than LTC4.
D001783:Blood Flow Velocity; D004305:Dose-Response Relationship, Drug; D004890:Erythema / Q000139:chemically induced; D006801:Humans; D008833:Microcirculation / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D013189:SRS-A / Q000494:pharmacology*; D012867:Skin / Q000098:blood supply*; D013997:Time Factors
D013189:SRS-A