[Inhibition of the renin-angiotensin system in the ischemic kidney].
By blocking the renin-angiotensin-system with saralasin or salt-loading the postischemic damage of the renal microcirculation is diminished. This can be realized in a markedly improved oxygenation of renal tissue. As a result of the improved microcirculation 60 minutes after a 120-minutes ischemic damage one can find a better filtration rate, i.e. tubular function in treated kidneys.
D000618:Aminohippuric Acids / Q000378:metabolism; D000818:Animals; D004285:Dogs; D007444:Inulin; D007511:Ischemia / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply*; D012084:Renin-Angiotensin System / Q000187:drug effects; D012504:Saralasin / Q000494:pharmacology
D000618:Aminohippuric Acids; D007444:Inulin; D012504:Saralasin
Blockade des Renin-Angiotensin-Systems an der ischämischen Niere.