Peptic ulcer complaints in lithium-treated and non-lithium-treated manic-depressive patients.
A possible protective effect of lithium against the occurrence of peptic ulcer complaints in manic-depressive patients, treated with lithium, was investigated. 167 manic-depressive patients, 91 in lithium treatment, 76 not in lithium treatment, were questioned about clinical symptoms of peptic ulcer. Thirteen of the lithium-treated and 23 of the non-lithium-treated patients reported symptoms of peptic ulcer. The difference was statistically significant. The hypothesis that lithium treatment reduces the frequency of symptoms of peptic ulcer in manic-depressive patients was thus confirmed.
D001714:Bipolar Disorder / Q000188:drug therapy*; D005755:Gastrins / Q000378:metabolism; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D010437:Peptic Ulcer / Q000517:prevention & control*
D005755:Gastrins; D008094:Lithium