4-Aminobutyraldehyde as a substance convertible in vivo to GABA.
[2,3-3H]4-Aminobutyraldehyde ([3H]ABAL) was injected subcutaneously into mice, which were sacrificed at various intervals following injection. [3H] gamma-Aminobutyric acid ([3H]GABA) synthesized in vivo from [3H]ABAL was extracted from the brains, separated, and quantitated. The results showed that in the brain, injected [3HABAL was rapidly transformed into [3H]GABA. [3H]ABAL may penetrate the blood--brain barrier into the central nervous system and then be oxidized to [3H]GABA.
D000447:Aldehydes / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D014316:Tritium; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis*
D000447:Aldehydes; D014316:Tritium; C006509:4-aminobutyraldehyde; D005680:gamma-Aminobutyric Acid