Myocardial imaging and metabolic studies with [17-123I]iodoheptadecanoic acid in patients with idiopathic congestive cardiomyopathy.
In twenty patients with primary congestive cardiomyopathy (COCM) the patterns of accumulation and washout of the fatty acid analogue [17-123I]iodoheptadecanoic acid (I-123 HA) were studied. In contrast to patients with ischemic heart disease, where reduced I-123 HA accumulation was correlated with stenosis of the main coronary arteries, thus usually involving larger wall segments, the patients with COCM concentrated I-123 HA heterogeneously in small spotty segments throughout the entire left-ventricular myocardium. The regional washout half-times varied between 15.1 and 116.2 min. It seems that in patients with severe COCM the elimination half-times are more prolonged than in early stages of the disease. There was no correlation between the regional uptake and the elimination half-times. Sequential myocardial imaging with I-123 HA appears useful for noninvasively diagnosis of COCM.
D009202:Cardiomyopathies / Q000000981:diagnostic imaging* / Q000378:metabolism; D003327:Coronary Disease / Q000000981:diagnostic imaging; D003971:Diastole; D005227:Fatty Acids / Q000378:metabolism; D006207:Half-Life; D006321:Heart / Q000000981:diagnostic imaging*; D006346:Heart Septum / Q000378:metabolism; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007457:Iodine Radioisotopes; D009206:Myocardium / Q000378:metabolism*; D011877:Radionuclide Imaging
D005227:Fatty Acids; D007457:Iodine Radioisotopes; C027252:17-iodoheptadecanoic acid