Work in progress. Gastrointestinal ulcerations: detection using a technetium-99m-labeled ulcer-avid agent.
Technetium-99m-labeled sucralfate, an ulcer-avid material, was shown in preliminary animal and human studies to be stable in vivo with good sensitivity. Eight experimentally produced discrete gastric ulcers in three rabbits were visualized using this material. Of seven human studies, four studies were true-positive and three were true-negative. It is suggested that Tc-99m-labeled sucralfate may prove to have significant clinical advantages for the evaluation of gastrointestinal ulcer disease and other diseases that are associated with loss of mucosal integrity. The method for labeling sucralfate with Tc-99m was developed by the authors.
D000535:Aluminum; D000818:Animals; D001241:Aspirin; D001466:Barium Sulfate; D004341:Drug Evaluation; D004724:Endoscopy; D005753:Gastric Mucosa / Q000000981:diagnostic imaging; D006801:Humans; D007553:Isotope Labeling / Q000379:methods; D015609:Organotechnetium Compounds; D010437:Peptic Ulcer / Q000000981:diagnostic imaging*; D011817:Rabbits; D011877:Radionuclide Imaging; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging; D013276:Stomach Ulcer / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology; D013392:Sucralfate; D013667:Technetium; D013997:Time Factors; D014018:Tissue Distribution
D015609:Organotechnetium Compounds; C038248:technetium Tc 99m sucralfate; D001466:Barium Sulfate; D013392:Sucralfate; D013667:Technetium; D000535:Aluminum; D001241:Aspirin