[Differences between the complexes formed by monomeric fibrin with fragment D and dimer D].
The paper is concerned with studies in formation of monomeric fibrin (fm) complexes with fragment D (D) of fibrinogen and dimer D (DD) of stabilized fibrin. The complexes are shown to be essentially different. The fm-D complexes are unstable, their composition is a function of D concentration in the mixture, the ultimate molar D/fm ratio is equal to 3. The fm-DD complexes are quite stable, their composition is constant: the molar DD/fm ratio is equal to 1. In mixtures containing fm, DD and different amounts of D complexes of different composition are formed but the total number of D-units in them approaches 3. A model is suggested showing interaction of fm molecules in protofibril formation with allowance for the retention of binding centres which provide the lateral link between protofibrils.
D000818:Animals; D002417:Cattle; D002850:Chromatography, Gel; D005337:Fibrin / Q000032:analysis*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D046911:Macromolecular Substances; D008958:Models, Molecular; D008968:Molecular Conformation; D011108:Polymers / Q000032:analysis*; D013816:Thermodynamics
D005338:Fibrin Fibrinogen Degradation Products; D046911:Macromolecular Substances; D011108:Polymers; C015214:fibrinogen D fragment; D005337:Fibrin
Razlichie mezhdu kompleksami, obrazuemymi monomernym fibrinom s fragmentom D i dimerom D.