Long-term and constant release of vasopressin from Accurel tubing: implantation in the Brattleboro rat.
A long-lasting and constant release of vasopressin in serum solution (in vitro) for periods up to 50 days can be obtained by the use of small-diameter microporous Accurel polypropylene tubing, filled with vasopressin and covered with collodion. The potency of the preparation is shown in vivo after subcutaneous implantation in the adult vasopressin-deficient Brattleboro rat, for which normal levels of urine production and osmolality were achieved at least for 1 month. The possible use of this method for other peptides and its application in small or immature laboratory animals and in fetuses is emphasized.
D000818:Animals; D003101:Collodion; D004343:Drug Implants; D008297:Male; D009994:Osmolar Concentration; D011126:Polypropylenes; D051381:Rats; D011910:Rats, Brattleboro; D014667:Vasopressins / Q000008:administration & dosage* / Q000652:urine
D004343:Drug Implants; D011126:Polypropylenes; D014667:Vasopressins; D003101:Collodion