[State of resistive blood vessels of the rat kidney during development of hereditary (spontaneous) hypertension].
Renal perfusion with Tyrode solution to which gelatinol was added revealed gradual development of structural changes in renal vessels as arterial hypertension was developing and stabilizing in spontaneously hypertensive rats, as evidenced by shifts in "perfusion pressure--perfusion rate" and "glomerular filtration rate--perfusion pressure" curves, increased afferent/efferent arteriole resistance ratio and enhanced renal vascular response to angiotensin II due to hypertrophy and reduced inner radius of smooth-muscle afferent arterioles. Considerable reduction in glomerular filtration rate combined with increased resistance to tissue liquid flow and less pronounced changes in renal flow suggests increased fluid elimination via arteriolovenous shunts at the stage of stable hypertension. The established renal vascular transformation may be needed to maintain high arterial blood pressure during stable hypertension.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006973:Hypertension / Q000209:etiology* / Q000235:genetics; D007668:Kidney / Q000098:blood supply*; D008297:Male; D009924:Organ Culture Techniques; D010477:Perfusion; D051381:Rats; D012077:Renal Artery / Q000503:physiopathology*; D014655:Vascular Resistance
D000804:Angiotensin II
Sostoianie rezistivnykh sosudov pochki u krys v dinamike razvitiia nasledstvenno obuslovlennoĭ (spontannoĭ) gipertenzii.