title: Influence of thioridazine on human cognitive, psychomotor, and reaction performance as well as subjective feelings.
abstract: The influence of thioridazine (1.0 and 1.5 mg/kg body wt.) on human performance was studied in healthy subjects in a double-blind trial vs placebo. Psychophysical performance was diminished dose-dependently. Reaction performance was clearly impaired only by the higher dose. The effect on cognitive performance varied, probably as a function of test-specific vigilance optima and the subjects' increase in reactive exertion. However, the subjective well-being of the subjects was impaired throughout.
mesh_terms: D000328:Adult; D003071:Cognition / Q000187:drug effects*; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects*; D013881:Thioridazine / Q000494:pharmacology*
chemical_list: D013881:Thioridazine