Normal vitamin E status in spinal muscular atrophy.
In an attempt to confirm prior reports of vitamin E deficiency in Werdnig-Hoffmann disease, we assessed vitamin E nutritional status in 11 children and 6 adults with spinal muscular atrophy (SMA). Serum vitamin E levels (10.6 +/- 3.3 micrograms/ml for those less than 12 years old, 13.2 +/- 4.5 for those older than 12) and the ratio of serum vitamin E to total serum lipids were normal in all patients. Vitamin E nutritional status appears to be normal in SMA, and vitamin E therapy is not indicated.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D009468:Neuromuscular Diseases / Q000097:blood*; D013118:Spinal Cord Diseases / Q000097:blood*; D014810:Vitamin E / Q000097:blood*
D008055:Lipids; D014810:Vitamin E