The effect of copper chelating drugs on liver iron mobilization in the adult rat.
To test the hypothesis that ferroxidase I (ceruloplasmin) activity is essential for iron mobilization, adult rats were fed a copper sufficient diet with or without the chelating drugs D-penicillamine and triethylenetetramine for 120 days. By day 6 of treatment and for the remainder of the experiment the drug-fed rats showed low plasma copper concentration and low ferroxidase I activity. Plasma ferroxidase II activity in the DPA and TETA groups tended to be slightly lower than that of controls. No animals became anemic. Therefore, persistent low plasma ferroxidase I does not necessarily cause anemia in the adult rat.
D000818:Animals; D002570:Ceruloplasmin / Q000378:metabolism*; D003300:Copper / Q000097:blood; D005029:Ethylenediamines / Q000494:pharmacology*; D005260:Female; D007501:Iron / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D010396:Penicillamine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014266:Trientine / Q000494:pharmacology*
D005029:Ethylenediamines; D003300:Copper; D007501:Iron; D002570:Ceruloplasmin; D010396:Penicillamine; D014266:Trientine