Calmodulin infused intracerebroventricularly enhances food intake in the cat.
In the fasted cat, calmodulin (CaM) infused into the cerebral ventricle produces an increase in the normal intake of food in a dose-dependent manner. The enhancement of feeding by CaM seems to be functionally specific since the response was: (1) abolished by the simultaneous intraventricular infusion of calcineurin, a specific CaM antagonist; (2) not mimicked by another calcium binding protein, troponin C; and (3) independent of the CaM's lack of effect on body temperature and water intake. This finding opens up the dual possibility that this Ca2+ binding protein may affect receptors other than intracellularly and that CaM is involved in specific functions controlled by the brain.
D000818:Animals; D001066:Appetite / Q000187:drug effects*; D002135:Calcium-Binding Proteins / Q000494:pharmacology*; D002147:Calmodulin / Q000008:administration & dosage / Q000494:pharmacology*; D002415:Cats; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D007276:Injections, Intraventricular
D002135:Calcium-Binding Proteins; D002147:Calmodulin