Susceptibility to phenytoin-induced cleft palate in mice is influenced by genes linked to H-2 and H-3.
Pregnant female mice of various congenic strains were injected on days 11 through 14 of gestation with phenytoin, and the fetuses were examined for the occurrence of cleft palate. The pattern of susceptibility indicates that two genes in the H-2 complex and another gene linked to H-3 are involved in the determination of this trait.
D000014:Abnormalities, Drug-Induced / Q000276:immunology; D000818:Animals; D002972:Cleft Palate / Q000139:chemically induced / Q000235:genetics* / Q000276:immunology; D005260:Female; D005327:Fetal Resorption; D005838:Genotype; D006183:H-2 Antigens / Q000235:genetics*; D008285:Major Histocompatibility Complex / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D010672:Phenytoin / Q000633:toxicity*; D011247:Pregnancy
D006183:H-2 Antigens; D010672:Phenytoin