Coincidence between fragile site expression and interstitial deletion of chromosome 11 in a case of myelofibrosis.
Cytogenetic examination of multiple peripheral blood cultures of a patient with myelofibrosis with myeloid metaplasia revealed the presence of an interstitial deletion of the long arm of chromosome 11, del(11)(q13q21). A folic acid dependent fragile site fra(11)(q13) was found in about 12% of the cells. The possible correlation between constitutional fragile site and acquired chromosomal alteration is discussed briefly.
D002872:Chromosome Deletion; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000235:genetics*