Functional capacity of sex-reversed (XX, Sxr/+) mouse germ cells as shown by progeny derived from XX, Sxr/+ oocytes of a female chimera.
Mice of the genotype X/X, Sxr/+ (Sex-reversed) are sterile phenotypic males. Testis size is reduced and there is a failure of spermatogenesis during meiosis I. A female chimeric mouse has been produced whose germ line is entirely composed of X/X, Sxr/+ germ cells. The progeny of this chimera included several XX, Sxr/+ males. The finding that X/X, Sxr/+ germ cells can produce fully functional oocytes has implications for the function of the Sex-reversed gene, the control of germ cell differentiation, and the role of germ cells in primary sex determination.
D000818:Animals; D002678:Chimera; D005260:Female; D005838:Genotype; D008297:Male; D051379:Mice; D009865:Oocytes / Q000503:physiopathology*; D010063:Ovum / Q000503:physiopathology*; D010641:Phenotype; D011247:Pregnancy; D012729:Sex Chromosome Aberrations / Q000235:genetics / Q000503:physiopathology*; D013737:Testis / Q000503:physiopathology*