Altered hepatic microsomal drug-metabolizing enzyme activity resulting from experimental infection of rats with Trypanosoma b. brucei.
Infection of experimental rats with Trypanosoma brucei (T. b. brucei) results in a decrease in the activities of aniline hydroxylase, aminopyrine-N-demethylase and a lowering of the level of reduced glutathione in the liver. The activity of cytochrome c reductase remains above normal 50 h after infection. Infection of animals previously treated with either phenobarbitone or 3-methylcholanthrene results in a reduction in the specific activity of aniline hydroxylase and aminopyrine-N-demethylase. However, the specific activity of aromatic hydrocarbon hydroxylase is not depressed in 3-methylcholanthrene-treated rats.
D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism; D003579:Cytochrome Reductases / Q000378:metabolism; D005260:Female; D008862:Microsomes, Liver / Q000201:enzymology*; D051381:Rats; D014346:Trypanosoma brucei brucei; D014353:Trypanosomiasis, African / Q000201:enzymology*
D000815:Aniline Hydroxylase; D001189:Aryl Hydrocarbon Hydroxylases; D000633:Aminopyrine N-Demethylase; D003579:Cytochrome Reductases