title: A cell-surface molecule involved in organ-specific homing of lymphocytes.
abstract: Lymphocytes migrate from the bloodstream by recognizing and binding to specialized endothelial cells lining the high endothelial venules (HEV) in lymph nodes and Peyer's patches. We describe here a monoclonal antibody, MEL-14, specific for a lymphocyte surface molecule that appears to mediate recognition of lymph node HEV, and to be required for lymphocyte homing into lymph nodes in vivo.
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D000954:Antigens, Surface / Q000032:analysis; D002448:Cell Adhesion; D002460:Cell Line; D004727:Endothelium / Q000276:immunology; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology; D051379:Mice; D008970:Molecular Weight; D009369:Neoplasms / Q000276:immunology; D010641:Phenotype; D051381:Rats
chemical_list: D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D000954:Antigens, Surface