Tumour-initiating activities of dihydrodiols of dibenz[a,c]anthracene.
The tumor-initiating activities of dibenz[a,c]anthracene (DBA) and of the related trans-1,2-, 3,4- and 10,11-dihydrodiols have been examined on mouse skin subsequently promoted with 12-O-tetradecanoyl-phorbol-13-acetate (TPA). The 1,2- and 10,11-dihydrodiols were active and were more active than equivalent doses of either the parent hydrocarbon or the 3,4-dihydrodiol. The data are discussed in relation to possible mechanisms that may be involved in the metabolic activation of DBA.
D000818:Animals; D001551:Benz(a)Anthracenes / Q000633:toxicity*; D005260:Female; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010704:Phorbols / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000139:chemically induced*; D013329:Structure-Activity Relationship; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D001551:Benz(a)Anthracenes; D010704:Phorbols; C006710:benzotriphenylene; D013755:Tetradecanoylphorbol Acetate