Interaction between ethanol and contraceptive steroids on clotting activity in the rat.
Female rats were given either ethinyl estradiol or norethindrone in conjunction with water or 5% ethanol. Hematological parameters measured included the prothrombin time (PT), partial thromboplastin time (APTT), fibrinogen (FIB), factors II, V, VII, VIII, X, and XII activity; plus the platelet count (PLT) and hematocrit (HCT). The data indicates that norethindrone together with water produces the greatest number of changes in clotting activity.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D009640:Norethindrone / Q000494:pharmacology*; D010976:Platelet Count; D051381:Rats; D011919:Rats, Inbred Strains; D014621:Vagina / Q000166:cytology / Q000187:drug effects
D000431:Ethanol; D004997:Ethinyl Estradiol; D009640:Norethindrone