On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid.
The histopathogenesis of rat forestomach carcinoma induced experimentally with aristolochic acid was investigated. The intragastric administration of 10 mg/kg/day caused extensive necrosis of the squamous epithelium, followed by regeneration and hyperplasia, papilloma formation and ultimately by invasive squamous cell carcinoma.
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D034341:Aristolochic Acids; D006965:Hyperplasia; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced; D010616:Phenanthrenes / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology
D000970:Antineoplastic Agents; D034341:Aristolochic Acids; D010616:Phenanthrenes; C000228:aristolochic acid I