title: Ascorbic acid inhibition of Campylobacter jejuni growth.
abstract: The inhibitory effect of ascorbic acid on Campylobacter jejuni is described. In vitro growth of clinical strains, as measured spectrophotometrically, was inhibited by 0.5 mg of freshly prepared L-ascorbic acid per ml. Alkaline-treated or aged L-ascorbic acid increased inhibition, as did copper; however, L-cysteine, L-cystine, and glutathione prevented inhibition. Biochemical analysis of the medium and cultures indicated that one or more of the oxidation products of L-ascorbic acid, e.g., L-dehydroascorbic acid or L-diketogulonic acid, were more effective inhibitors than was reduced L-ascorbic acid.
mesh_terms: D001205:Ascorbic Acid / Q000378:metabolism*; D002167:Campylobacter / Q000254:growth & development* / Q000378:metabolism; D003470:Culture Media
chemical_list: D003470:Culture Media; D001205:Ascorbic Acid