Contraceptive efficacy of testosterone-estradiol implants in male rhesus monkeys.
Rhesus monkeys (Macaca mulatta) were treated with testosterone (100 micrograms/kg/day) plus estradiol (0.5 micrograms/kg/day) via subcutaneous polydimethylsiloxane (PDS, Silastic) implants. This treatment caused a striking reversible sterility. No pregnancies were observed in females bred to the steroid-treated males. In contrast, there was no difference in pregnancy rate of females bred to control and steroid-treated monkeys for 14 weeks, beginning 17 weeks after removal of the steroid-filled implants.
D000818:Animals; D001774:Blood Chemical Analysis; D003272:Contraceptive Agents, Male / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004958:Estradiol / Q000494:pharmacology*; D005298:Fertility / Q000187:drug effects*; D008253:Macaca mulatta; D008297:Male; D012661:Semen / Q000032:analysis; D013094:Spermatozoa / Q000187:drug effects; D013739:Testosterone / Q000494:pharmacology*
D003272:Contraceptive Agents, Male; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D013739:Testosterone; D004958:Estradiol