[Distribution of kanamycin and cefazolin in the body of dogs with various types of small intestine infarcts].
Study of the pharmacokinetics of kanamycin and cefazolin in various types of experimental infarction of the small intestine showed their satisfactory penetration capacity with respect to the body fluids (blood, lymph, peritoneal exudate) and tissues (small and large intestine, parietal peritoneum, small intestine mesentery, gastrocolic omentum). This capacity was also shown with respect to the small intestine and its mesentery affected by infarction. Tissues traumatized during surgical operations were saturated with the antibiotics in concentrations equal to those in the control animals. The maximum concentrations of the antibiotics in the biosubstrates studied were observed by the 1st hour from the moment of their intramuscular injection. For prophylaxis of postoperative infections it is recommended that the antibiotics be applied not later than 1 hour before operation. This time is considered to be optimal.
D000818:Animals; D002437:Cefazolin / Q000378:metabolism*; D004285:Dogs; D005260:Female; D007238:Infarction / Q000378:metabolism*; D007421:Intestine, Small / Q000098:blood supply*; D007612:Kanamycin / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D013997:Time Factors; D014018:Tissue Distribution
D007612:Kanamycin; D002437:Cefazolin
Raspredelenie kanamitsina i tsefazolina v organizme sobak pri razlichnykh tipakh infarktov tonkoĭ kishki.