A comparison of a disposable membrane filtration system with a direct inoculation system for the sterility testing of veterinary biologics.
A direct inoculation method for sterility testing veterinary biologics was compared with a closed membrane filtration method (Steritest). The filtration method detected extraneous contamination in 29% more batches of biologics than the direct inoculation method. Live viral biologics produced in cell culture were found to be the only product type that could be filtered; hence the filtration method cannot be recommended universally as a replacement for the direct inoculation method.
D000818:Animals; D001688:Biological Products / Q000592:standards*; D005374:Filtration; D013242:Sterilization / Q000592:standards*; D014730:Veterinary Medicine; D014765:Viral Vaccines / Q000592:standards
D001688:Biological Products; D014765:Viral Vaccines