Laryngeal paraganglioma. Report of two tumors with immunohistochemical and ultrastructural analysis.
Paraganglionic tumors of the larynx are uncommon neoplasms and their secretory products have rarely been elucidated. We saw two patients whose laryngeal paragangliomas were examined with an electron microscope and by the use of immunocytochemical techniques. Both tumors manifested positive immunoreactivity against calcitonin and vasoactive intestinal polypeptide. One of the paragangliomas was immunoreactive against carcinoembryonic antigen and pursued a biologically malignant course. Our observations suggest the coexistence of amines and hormonal polypeptides in cells of paraganglionic tumors and demonstrate the multihormonal nature of these tumors.
D000368:Aged; D002116:Calcitonin / Q000276:immunology; D002272:Carcinoembryonic Antigen / Q000276:immunology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D010235:Paraganglioma / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure*; D014660:Vasoactive Intestinal Peptide / Q000276:immunology
D002272:Carcinoembryonic Antigen; D014660:Vasoactive Intestinal Peptide; D002116:Calcitonin