[Thermodynamic instability of cholesterol-containing vesicles].
The temporal behavior of aqueous dispersion of the phosphatidylcholine-cholesterol vesicles was studied by photon correlation spectroscopy. The analysis of scattered light spectra by the regularisation method permits one to determine the distribution of vesicles over their dimensions. It was found that the system of the phosphatidylcholine-cholesterol vesicles is thermodynamically instable; this system segregates with time into two fractions of large and small particles. The possible causes of this phenomenon are discussed.
D002784:Cholesterol; D004355:Drug Stability; D008081:Liposomes; D010713:Phosphatidylcholines; D013816:Thermodynamics
D008081:Liposomes; D010713:Phosphatidylcholines; D002784:Cholesterol
Termodinamicheskaia neravnovesnost' vezikul, soderzhashchikh kholesterin.