title: Radionuclide angiocardiography: an improved deconvolution technique for improvement after suboptimal bolus injection.
abstract: Deconvolution is a mathematical technique used to improve radionuclide angiocardiography after suboptimal injection of radiopharmaceutical. A new deconvolution algorithm designed to be relatively insensitive to the random errors that occur in experimental data was tested. First-pass radionuclide angiocardiography using iridium-191m was performed to quantitate left-to-right shunting in normal dogs and dogs with atrial septal defects. Deconvolution was used to correct for injection shape. Four quantitation techniques were studied (good injection/no deconvolution, good injection/deconvolution, fragmented injection/no deconvolution, fragmented injection/deconvolution). The mean (p less than .001) and standard deviation (p less than .0001) of the fragmented injection/no deconvolution technique were significantly different from the other three techniques, which were not significantly different from each other (mean or standard deviation) at the p = 0.05 level. This deconvolution method made it possible to accurately quantitate left-to-right shunts even with fragmented injections.
mesh_terms: D000818:Animals; D003201:Computers; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D004285:Dogs; D004560:Electricity; D006331:Heart Diseases / Q000000981:diagnostic imaging*; D006344:Heart Septal Defects, Atrial / Q000000981:diagnostic imaging; D006346:Heart Septum / Q000000981:diagnostic imaging*; D007495:Iridium; D008433:Mathematics; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013679:Technology, Radiologic
chemical_list: D011868:Radioisotopes; D007495:Iridium