The effect of piroxicam on neutrophil and monocyte-macrophage function.
The effect of piroxicam on neutrophil and monocyte chemotaxis was evaluated in vitro and in vivo. Piroxicam demonstrated a marked inhibitory activity on neutrophil chemotaxis and to a lesser extent on monocyte chemotaxis. The data here presented supports the notion that piroxicam interfere with the inflammatory process by affecting primarily neutrophil and to a lesser degree monocyte function.
D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D006801:Humans; D008264:Macrophages / Q000378:metabolism*; D009000:Monocytes / Q000187:drug effects*; D009504:Neutrophils / Q000187:drug effects*; D010894:Piroxicam; D013843:Thiazines / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D013843:Thiazines; D010894:Piroxicam