A possible Ca2+-induced Ca2+ release mechanism mediated by norepinephrine in vascular smooth muscle.
In vascular smooth muscle, the norepinephrine-sensitive Ca2+ store is distinct from the sarcoplasmic reticulum. Under physiological conditions, Ca2+ released from the norepinephrine-sensitive store may induce Ca2+ release from the sarcoplasmic reticulum, i.e. norepinephrine mediated activation may involve a Ca2+-induced Ca2+ release mechanism.
D000818:Animals; D001696:Biomechanical Phenomena; D002110:Caffeine / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism* / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D009638:Norepinephrine / Q000494:pharmacology*; D011817:Rabbits
D002110:Caffeine; D002118:Calcium; D009638:Norepinephrine