Fatal interaction between thiamylal sodium and a proprietary antidiarrheal preparation in the dog.
A drug interaction involving thiamylal sodium and a proprietary antidiarrheal preparation caused fatal ventricular fibrillation in a dog. Trials involving 4 dogs were conducted to recreate the interaction, and 1 of the 4 dogs died after ventricular fibrillation developed. The nature of the interaction was hypothesized to be mediated through the anticholinergic drug diphemanil methylsulfate, producing an autonomic imbalance.
D000777:Anesthetics / Q000009:adverse effects*; D000818:Animals; D000930:Antidiarrheals / Q000009:adverse effects*; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D004347:Drug Interactions; D008297:Male; D013840:Thiamylal / Q000009:adverse effects*
D000777:Anesthetics; D000930:Antidiarrheals; D013840:Thiamylal