[Molecular mechanisms of interaction between blood serum albumin and dinitroorthocresol].
Interactions of dinitroortocresol with human blood serum albumin were studied using equilibrium dialysis, spectrofluorimetry and polarography. Two classes of binding sites were found in the protein molecule: high-affinity site, binding 4 molecules of cresol and a low-affinity site, binding up to 12 molecules. Binding of dinitroortocresol occurred simultaneously with alteration in the albumin molecule conformation.
D001665:Binding Sites; D003408:Cresols / Q000097:blood*; D003956:Dialysis; D004138:Dinitrocresols / Q000097:blood*; D006540:Herbicides / Q000097:blood*; D006801:Humans; D007700:Kinetics; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism*
D003408:Cresols; D004138:Dinitrocresols; D006540:Herbicides; D012709:Serum Albumin; C024132:4,6-dinitro-o-cresol
Molekuliarnye mekhanizmy vzaimodeĭstviia syvorotochnogo al'bumina s dinitroortokrezolom.