Effect of the plasticizer di(2-ethylhexyl) adipate (dioctyladipate, DOA) on lipid metabolism in the rat: I. Inhibition of cholesterolgenesis and modification of phospholipid synthesis.
DOA (di[2-ethylhexyl] adipate, dioctyladipate), a plasticizer used in the manufacture of polyvinyl-chloride plastic products, has been considered as a suitable substitute for di(2-ethylhexyl)phthalate (DEHP) in some applications. In the present studies, hepatic lipid metabolism was examined in liver mince preparations from rats fed 0.5% or 1.0% DOA in the diet for 2 weeks. By studying patterns of lipid synthesis from [14C] acetate, [14C] oleate, [14C] mevalonate, and [14C] octanoate, it was concluded that DOA feeding inhibits hepatic cholesterolgenesis and alters the pattern of phospholipids synthesized by the liver. DOA also exerted a cholesterol-lowering effect at the 1% level but did not affect plasma triglyceride levels. The results suggest that the biological effects of DOA in the rat are similar to those produced by DEHP.
D000272:Adipates / Q000494:pharmacology*; D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis* / Q000097:blood; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000096:biosynthesis*; D010968:Plasticizers / Q000494:pharmacology*; D051381:Rats; D014280:Triglycerides / Q000097:blood
D000272:Adipates; D010743:Phospholipids; D010968:Plasticizers; D014280:Triglycerides; C013966:dioctyl adipate; D002784:Cholesterol