In vivo percutaneous absorption of hydrocortisone in psoriatic patients and normal volunteers.
Our objective was to determine the percutaneous absorption of hydrocortisone in psoriatic skin. [14C]-Hydrocortisone formulated as a 0.5% cream was applied to sharply defined erythematous plaques with silvery scales on the dorsal forearm of four hospitalized psoriatic patients. An average 2.32 +/- 1.4 (SD) percent of the applied dose was absorbed. The absorption of the same dose from the dorsal forearm of six normal subjects was 2.45 +/- 1.2%. We conclude that for presumably stable psoriatic plaques, the percutaneous absorption of hydrocortisone is the same as for normal skin.
D000328:Adult; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000378:metabolism*; D012869:Skin Absorption
D006854:Hydrocortisone