Opioid peptides. Structure-activity relationships in dermorphin pentapeptides III.
The synthesis and preliminary pharmacological in vitro of seventeen pentapeptide analogs of the opioid peptide dermorphin are reported. Substitution at residue Tyr5 and/or modification of C-terminal are generally well tolerated.
D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004558:Electric Stimulation; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009294:Narcotics; D009842:Oligopeptides / Q000494:pharmacology*; D018847:Opioid Peptides; D010446:Peptide Fragments / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014649:Vas Deferens / Q000187:drug effects
D009294:Narcotics; D009842:Oligopeptides; D018847:Opioid Peptides; D010446:Peptide Fragments; C030058:dermorphin