Safety of fenbendazole in swine.
The safety of fenbendazole, an anthelmintic for use in swine, was tested by feeding 0, 25, 75, or 125 mg of fenbendazole/kg of body weight for 5 days. A dose-related transient leukopenia developed on day 7, but values returned to base line on day 15. In the groups fed 75 or 125 mg, sorbitol dehydrogenase activity increased on day 3 but returned to base line on day 10. Significant gross or histopathologic lesions were not found.
D000818:Animals; D001562:Benzimidazoles / Q000633:toxicity*; D001769:Blood / Q000187:drug effects; D005260:Female; D005273:Fenbendazole / Q000633:toxicity*; D007064:L-Iditol 2-Dehydrogenase / Q000032:analysis; D007958:Leukocyte Count; D010758:Phosphorus / Q000097:blood; D013552:Swine / Q000097:blood
D001562:Benzimidazoles; D010758:Phosphorus; D005273:Fenbendazole; D007064:L-Iditol 2-Dehydrogenase