Metastasis of an optic glioma through a ventriculoperitoneal shunt.
Metastatic spread of an optic glioma through a ventriculoperitoneal shunt resulted in the accumulation of malignant ascites in a young boy. Chemotherapy with vincristine, CCNU, and prednisone resulted in regression of the ascites and no further tumor progression. Extracranial metastasis of such a slow growing tumor is a rare occurrence; however, in this case, the spread through the shunt further emphasizes the need for protective filters in the shunts.
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001201:Ascites / Q000188:drug therapy* / Q000209:etiology; D001254:Astrocytoma / Q000188:drug therapy / Q000473:pathology*; D002675:Child, Preschool; D003390:Cranial Nerve Neoplasms / Q000188:drug therapy / Q000473:pathology*; D004359:Drug Therapy, Combination; D006801:Humans; D008130:Lomustine / Q000008:administration & dosage; D008297:Male; D009897:Optic Chiasm; D011241:Prednisone / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D000970:Antineoplastic Agents; D014750:Vincristine; D008130:Lomustine; D011241:Prednisone