title: [Side effects of anthralin and its 2 main impurities on healthy skin].
abstract: In 20 volunteers, we were able to demonstrate experimentally that side-effects of anthralin application on healthy skin development of erythema and pigmentation, can be significantly reduced in a short contact therapy, in comparison to a longterm treatment. The oxydation products 1.8-dihydroxy-9.10-anthraquinone and 10.10'-dimer which are considered the main impurities of anthralin do not cause any irritation on healthy skin.
mesh_terms: D000873:Anthracenes; D000875:Anthralin / Q000009:adverse effects / Q000031:analogs & derivatives; D000880:Anthraquinones / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004890:Erythema / Q000139:chemically induced; D006801:Humans; D010084:Oxidation-Reduction; D012867:Skin / Q000187:drug effects*
chemical_list: D000873:Anthracenes; D000880:Anthraquinones; C037967:anthralin 10,10'-dimer; D000875:Anthralin; C004315:danthron
vernacular_title: Untersuchungen zur Frage der Nebenwirkungen von Anthralin und seinen beiden Hauptverunreinigungen an der gesunden Haut.