The effect of pentylenetetrazol on the levels of dopamine-beta-hydroxylase in the cerebrospinal fluid of rabbits: a dose-dependent relationship.
The effect of various doses of pentylenetetrazol (PTZ) on the levels of dopamine-beta-hydroxylase (D beta H) and acetylcholinesterase (AChE) in the CSF of rabbits was studied. The drug augments in a dose-dependent manner the D beta H activity but causes only a small and dose-independent increase in AChE. This suggests that PTZ-induced convulsions are associated with an increase in central noradrenergic activity but not by an increase in central cholinergic activity.
D000110:Acetylcholinesterase / Q000134:cerebrospinal fluid; D000818:Animals; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D004299:Dopamine beta-Hydroxylase / Q000134:cerebrospinal fluid*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology*; D011817:Rabbits / Q000134:cerebrospinal fluid*
D002556:Cerebrospinal Fluid Proteins; D004299:Dopamine beta-Hydroxylase; D000110:Acetylcholinesterase; D010433:Pentylenetetrazole