Functional correlations between lateral hypothalamic glucose-sensitive neurons and hepatic portal glucose-sensitive units in rat.
The effects of glucose injection into the hepatic portal vein on neural activity of the lateral hypothalamic area (LHA) were studied in rats. A majority of identified glucose-sensitive neurons in the LHA were inhibited by portal injection of glucose. This was found to be mediated through the alpha-noradrenergic pathways. Most of the glucose-insensitive neurons did not respond to the same procedure. Portal injection of hypertonic saline increased neural activity of some glucose-insensitive neurons but no glucose-sensitive neurons responded. Convergence of hepatic vagal afferent glucose-sensitive units on LHA glucose-sensitive neurons was clarified by this study.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001786:Blood Glucose / Q000502:physiology*; D001931:Brain Mapping; D002628:Chemoreceptor Cells / Q000502:physiology; D005260:Female; D007026:Hypothalamic Area, Lateral / Q000502:physiology*; D008099:Liver / Q000294:innervation*; D008297:Male; D009638:Norepinephrine / Q000502:physiology; D011169:Portal Vein; D051381:Rats; D011919:Rats, Inbred Strains; D014630:Vagus Nerve / Q000502:physiology*
D001786:Blood Glucose; D009638:Norepinephrine