[Cytotoxic effect of methionine-gamma-lyase on neoplastic cells in culture].
The influence of methionine-gamma-lyase from Pseudomonas putida on DNA synthesis by CaOv and L-8 cell lines has been studied. The agent has been demonstrated to inhibit the incorporation of 3H-thymidine into L-8 cell line and to have no effect on CaOv cells.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D013437:Carbon-Sulfur Lyases / Q000494:pharmacology*; D002478:Cells, Cultured / Q000187:drug effects; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D005260:Female; D007739:L Cells / Q000187:drug effects; D008190:Lyases / Q000494:pharmacology*; D051379:Mice; D010051:Ovarian Neoplasms; D011549:Pseudomonas / Q000201:enzymology
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D008190:Lyases; D013437:Carbon-Sulfur Lyases; C021558:L-methionine gamma-lyase
Tsitotoksicheskiĭ éffekt metionin-gamma-liazy na rakovye kletki v kul'ture.