Pharmacokinetics and pharmacodynamics of drug delivery.
The complex pharmacokinetics that promote transit of a drug from ingestion to elimination are characterized by variability. The rate and degree to which a drug undergoes absorption, distribution, biotransformation and excretion are a result of both endogenous and exogenous factors, some of which can be predicted, many of which cannot. One of the greatest problems associated with conventional drug formulations has been the dose-related appearance of side-effects that often accompany the initial surge of drug release. Drugs with short half-lives or narrow therapeutic ratios may alternately produce over-medication and under-medication in a patient. Innovations in drug form design have resulted in a new precision-release formulation that permits zero-order steady state drug release. Sodium indomethacin trihydrate ('Osmosin') is the first drug to be contained within this new precision-release formulation which approaches the objective of delivering drugs at a therapeutically optimal rate.
D000042:Absorption; D001711:Biotransformation; D003692:Delayed-Action Preparations; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism; D014018:Tissue Distribution
D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations; D007213:Indomethacin