[Value of skeletal scintigraphy in the follow-up of breast cancer].
In a retrospective study of 728 patients with breast cancer up to 3 years after primary treatment skeletal scintigraphy yielded 15.8% (n = 115) bone metastases. By scintigraphic differentiation between a typical and an untypical pattern of bone metastasis a diagnostic accuracy of 99% was found. Depending on the local stage of tumor the rate of osseous metastases rises with increasing tumor size and with the extent of metastatic involvement of the lymph nodes. The frequency of bone metastasis proved to be also dependent on the histological type of tumor; it was highest in scirrhous carcinomas. By evaluating the scintigraphic behaviour of skeletal metastases under treatment in 122 patients we revealed an obvious decrease of metastatic deposits or complete normalization in 11.5% (n = 14), an unchanged finding in 32% (n = 39) and a progression of metastasis in 56.5% (n = 69). Therefore scintigraphic bone imaging in follow-up of breast cancer can be recommended for early detection of osseous metastases and for assessing the response of skeletal metastases to treatment.
D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D011877:Radionuclide Imaging; D012189:Retrospective Studies
Die Bedeutung der Skelettszintigraphie in der Nachsorge des Mammakarzinoms.