Chemiluminescence response of human blood mononuclear cells to PHA and histamine.
Phytohaemagglutinin (PHA) elicited a short early chemiluminescence (CL) response of human blood mononuclear cells with a maximum at 2.5 min. The magnitude of the CL production was a function of the PHA concentration used. The CL response could be dose-dependently inhibited by histamine. In the presence of mepyramine the action of histamine was more pronounced while a dose-dependent reversal of the inhibition was found by cimetidine.
D002927:Cimetidine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D008163:Luminescent Measurements; D008214:Lymphocytes / Q000187:drug effects*; D010835:Phytohemagglutinins / Q000494:pharmacology*
D010835:Phytohemagglutinins; D002927:Cimetidine; D006632:Histamine