Neo-kyotorphin (Thr-Ser-Lys-Tyr-Arg), a new analgesic peptide.
The amino acid sequence of a newly isolated pentapeptide, neo-kyotorphin from bovine brain was synthetically verified to be Thr-Ser-Lys-Tyr-Arg corresponding to the C-terminal portion of hemoglobin alpha-chain. The synthetic neo-kyotorphin showed the dose-dependent analgesia in mice which was approximately equal to that of Leu-enkephalin.
D000595:Amino Acid Sequence; D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D002417:Cattle; D004723:Endorphins / Q000302:isolation & purification*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects
D000700:Analgesics; D004723:Endorphins; C036450:neo-kyotorphin