Comparative activity of amantadine and ribavirin against influenza virus in vitro: possible clinical relevance.
The activities of amantadine and ribavirin against influenza A viruses were compared against low-multiplicity (plaque inhibition) and high-multiplicity (protein synthesis inhibition) infections. Our results suggest that the predictive value of in vitro data for the clinic may be improved by consideration of tests against a high-multiplicity infection.
D000547:Amantadine / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004285:Dogs; D006801:Humans; D007251:Influenza, Human / Q000188:drug therapy; D008826:Microbial Sensitivity Tests; D009975:Orthomyxoviridae / Q000187:drug effects*; D012254:Ribavirin / Q000494:pharmacology* / Q000627:therapeutic use; D012263:Ribonucleosides / Q000494:pharmacology*
D012263:Ribonucleosides; D012254:Ribavirin; D000547:Amantadine