The effect of disulfiram on the urinary excretion of catecholamine metabolites in alcoholic males.
The urinary excretion of vanillylmandelic acid (VMA), homovanillic acid (HVA) and total metanephrines (TMNs) was studied in a group of White male alcoholic patients under three experimental conditions--on admission and prior to treatment, after 7 days of administration of a placebo, and after 9 days of administration of disulfiram 400 mg/d Disulfiram caused a significant decrease in VMA levels compared with the pretreatment (P less than 0,01) and placebo (P less than 0,05) levels. The output of HVA and TMNs was unchanged. It is suggested that disulfiram may produce false-negative results in cases of suspected phaeochromocytoma if VMA levels only are assayed. TMNs would appear to be the measurement of choice in such a situation.
D000328:Adult; D000437:Alcoholism / Q000188:drug therapy*; D004221:Disulfiram / Q000494:pharmacology*; D004837:Epinephrine / Q000031:analogs & derivatives*; D006719:Homovanillic Acid / Q000652:urine*; D006801:Humans; D008297:Male; D008676:Metanephrine / Q000652:urine*; D008875:Middle Aged; D010648:Phenylacetates / Q000652:urine*; D014642:Vanilmandelic Acid / Q000652:urine*
D010648:Phenylacetates; D008676:Metanephrine; D014642:Vanilmandelic Acid; D004221:Disulfiram; D006719:Homovanillic Acid; D004837:Epinephrine