[Molecular structure with potential inhibitory action on the biosynthesis of FAH4].
Molecules formed by two pharmacophoric synthons--4-H2N--C6H4--SO2NH--and 2,4-diaminopyrimidine--were prepared. These structural units, with sulphamidic and antifolic action respectively, are bound without mutual electronic interaction, as demonstrated by their experimental electronic indices. The compounds were tested for activity on several bacterial strains and their biological activity was compared with that of molecular combinations formed by 4-aminobenzensulphonamide and substituted 2,4-diaminopyrimidines, to discover whether these two pharmacophoric synthons, so bound, are synergic.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology; D013763:Tetrahydrofolates / Q000096:biosynthesis*
D000900:Anti-Bacterial Agents; D011743:Pyrimidines; D013449:Sulfonamides; D013763:Tetrahydrofolates; C030371:5,6,7,8-tetrahydrofolic acid
Strutture molecolari a potenziale azione inibitrice della biosintesi del FAH4.