Endogenous opiates mediate radiogenic behavioral change.
Exposure of C57BL/6J mice to ionizing radiation caused stereotypical locomotor hyperactivity similar to that produced by morphine. Naloxone administration prevented this radiation-induced behavioral activation. These results support the hypothesis that endorphins are involved in some aspects of radiogenic behavioral change.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004723:Endorphins / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000528:radiation effects; D009270:Naloxone / Q000494:pharmacology
D004723:Endorphins; D009270:Naloxone