Hepatic proline after bile duct ligation in rats.
Since biliary hyperplasia of fascioliasis correlated with hepatic proline level, we examined the occurrence of a similar chemical stimulus during bile obstruction. Uptake of tritiated proline and glycine rose in both hepatocytes and a bile duct enriched cell fraction, following duct ligation in rats. The increased hepatic content of proline but not glycine suggests that proline has a role in post-obstructive biliary proliferation.
D000818:Animals; D001651:Cholestasis, Extrahepatic / Q000378:metabolism*; D003135:Common Bile Duct / Q000502:physiology*; D005998:Glycine / Q000378:metabolism; D008026:Ligation; D008099:Liver / Q000378:metabolism*; D008297:Male; D011392:Proline / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D011392:Proline; D005998:Glycine