title: Plasma lignocaine concentrations following topical laryngeal application.
abstract: Lignocaine 4%, 4 mg/kg, was sprayed onto the larynx and subglottic area of 96 children aged from 2 weeks to 12 years and plasma lignocaine concentrations were measured. While the majority were well within the accepted safe range (4.5 micrograms/ml) occasional concentrations over 8 micrograms/ml appeared in all groups. Simultaneous arterial and venous sampling showed a small but significant difference in the first 10 minutes.
mesh_terms: D000287:Administration, Topical; D000336:Aerosols; D000367:Age Factors; D000772:Anesthesia, Local; D001158:Arteries; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007830:Larynx; D008012:Lidocaine / Q000008:administration & dosage / Q000097:blood* / Q000633:toxicity; D013997:Time Factors; D014680:Veins
chemical_list: D000336:Aerosols; D008012:Lidocaine