Autoimmune haemolytic disease in mice after exposure to a methylating carcinogen.
N-Methyl-N-nitrosourea (MNU) but not methyl methanesulphonate (MMS) induced both autoimmune haemolytic anaemia and thymic lymphoma in susceptible strains of mice, particularly the C57BL/6. These effects could be positively correlated with the formation of O6-methylguanine in target DNA. All murine lymphoid cells showed lack of ability to remove O6-methylguanine from their DNA, therefore the variation of responses between different mouse strains indicated that other host factors, probably genetic, must be involved. The results do indicate however that a potent pre-mutagenic DNA base modification can initiate the events leading to autoimmune disease in susceptible mice.
D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced*; D000818:Animals; D004247:DNA / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006147:Guanine / Q000031:analogs & derivatives / Q000378:metabolism; D008741:Methyl Methanesulfonate / Q000633:toxicity; D008745:Methylation; D008770:Methylnitrosourea / Q000633:toxicity*; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009607:Nitrosourea Compounds / Q000633:toxicity*; D013045:Species Specificity; D013154:Spleen / Q000187:drug effects; D013945:Thymoma / Q000139:chemically induced; D013953:Thymus Neoplasms / Q000139:chemically induced
D009607:Nitrosourea Compounds; D006147:Guanine; D008770:Methylnitrosourea; D004247:DNA; C008449:O-(6)-methylguanine; D008741:Methyl Methanesulfonate