Metabolic inactivation of noradrenaline in human placenta, umbilical cord and fetal membranes.
Metabolic inactivation of noradrenaline (NA) was studied in human placenta, umbilical vessels, Wharton's jelly and fetal membranes. Highest degradation capacity was observed in the placenta and fetal membranes, where the NA was inactivated by both monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT). No MAO and COMT activity was found in the cord jelly and the activities in umbilical vessels were very low.
D002394:Catechol O-Methyltransferase / Q000378:metabolism; D005321:Extraembryonic Membranes / Q000378:metabolism; D005260:Female; D006801:Humans; D008995:Monoamine Oxidase / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D014470:Umbilical Cord / Q000378:metabolism
D008995:Monoamine Oxidase; D002394:Catechol O-Methyltransferase; D009638:Norepinephrine