The non-specific enhancement of allergy. I. In vivo effects of Bordetella pertussis vaccine on IgE synthesis.
Bordetella pertussis organisms, with or without a small dose of alumhydroxide, enhance in rats the production of IgE antibodies to an unrelated antigen, even if this antigen has been administered 6 weeks beforehand. This non-specific enhancement of IgE antibodies is accompanied by a substantial rise in total serum IgE and by the production of IgE antibodies to B. pertussis. The effect of B. pertussis on IgE synthesis is dose-dependent. No effect of B. pertussis on IgE production can be observed in nude rats.
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000536:Aluminum Hydroxide / Q000008:administration & dosage / Q000276:immunology; D000818:Animals; D000918:Antibody Specificity; D004195:Disease Models, Animal; D004306:Dose-Response Relationship, Immunologic; D007073:Immunoglobulin E / Q000032:analysis / Q000096:biosynthesis*; D010047:Ovalbumin / Q000276:immunology; D010567:Pertussis Vaccine / Q000008:administration & dosage* / Q000276:immunology; D051381:Rats; D011914:Rats, Inbred BN; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains; D012130:Respiratory Hypersensitivity / Q000276:immunology*
D000276:Adjuvants, Immunologic; D010567:Pertussis Vaccine; D007073:Immunoglobulin E; D000536:Aluminum Hydroxide; D010047:Ovalbumin