[Effect of armin on the microcirculation of the cerebral cortex of white rats].
Experiments on white male Wistar rats with the use of the cinetelevision technique have shown that armine in a single LD50 provokes a 85-100% increase in the blood flow rate in the microvessels and a 45-50% elevation of the diameter of the pial arterioles. Administration of the drug in a dose of 1/2 of the LD50 brings about a 90% increase in the blood flow rate, whereas the diameter of the arterioles declines by 25%. The LD50 of armine lowers the cholinesterase activity in the brain and blood by 50-60%, while 1/2 of the drug LD50 by 20-30%.
D000818:Animals; D001138:Armin / Q000506:poisoning*; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects; D002540:Cerebral Cortex / Q000098:blood supply* / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D062025:Organophosphate Poisoning; D051381:Rats; D011919:Rats, Inbred Strains
D001138:Armin
Vliianie armina na mikrotsirkuliatsiiu v kore golovnogo mozga belykh krys.