Antitumor activity of some diorganotin and tin(IV) complexes of Schiff bases.
Some new di-n-butyltin and tin(IV) complexes of the type Bu2SnL, Bu2SnL2 and SnL2 (where L = anions of Schiff bases derived from S-substituted dithiocarbazates and fluoro-aniline) have been prepared and screened for their antitumor activity in P 388 Lymphocyte Leukaemia system. These complexes do not show any toxicity at low dose levels and display T/C values in the range 94-124. Di-n-butyltin complex derived from salicylaldehyde-S-methyl dithiocarbazate has been found to be the most active in this series.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D007941:Leukemia P388 / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008297:Male; D051379:Mice; D009947:Organotin Compounds / Q000627:therapeutic use*; D012545:Schiff Bases / Q000627:therapeutic use; D014001:Tin / Q000627:therapeutic use*
D009947:Organotin Compounds; D012545:Schiff Bases; D014001:Tin