title: Multiple large cell acanthomas.
abstract: Large cell acanthoma is a benign keratosis which occurs as a generally hyperkeratotic, sharply demarcated patch on actinically exposed skin. Clinically, it is usually misdiagnosed as a seborrheic keratosis or solar keratosis. The first two reports of multiple large cell acanthomas are described here. Clinical and histologic features were identical to a control series of sixteen solitary large cell acanthomas. Large cell acanthomas should be considered in the differential diagnosis of solitary and multiple keratoses on sun-exposed skin.
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007642:Keratosis / Q000175:diagnosis; D008875:Middle Aged; D010212:Papilloma / Q000175:diagnosis* / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology; D013472:Sunlight / Q000009:adverse effects