A technique for the comparison of biological distribution and solvent partition of drugs.
A dialysis technique is described which allows the measurement of drug distribution between buffer and solvents as well as between buffer and biological preparations under identical experimental conditions. Partition and distribution coefficients of thiopental, pentobarbital, imipramine, and chlorpromazine were determined using octanol, other solvents, and tissue homogenates.
D000818:Animals; D002021:Buffers; D003956:Dialysis / Q000379:methods; D006863:Hydrogen-Ion Concentration; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010600:Pharmacology / Q000379:methods*; D051381:Rats; D012997:Solvents / Q000494:pharmacology*; D014018:Tissue Distribution
D002021:Buffers; D004364:Pharmaceutical Preparations; D012997:Solvents