[Morphometric study of the taste buds in rat tongue after colchicine application to the glossopharyngeal nerve].
Colchicine application on the glossopharyngeal nerve produces a decrease in number and size of the taste buds in the foliate papillae of the tongue, in amount of cells in the buds, as well as certain changes in the nuclear area of these cells on the ipsilateral side. Correlation of normal amount of dark, light and intermediate cells (62, 26, 12, correspondingly) changes: the amount of the dark cells decreases, while the relative amount of the intermediate cells increases. An analogous but less pronounced phenomenon is observed on the contralateral side. Similar changes are also observed after the nerve cutting at the same side where colchicine is applied. But these changes develop more quickly. The results obtained demonstrate that every cell type of the taste bud responds specifically to the trophic effect of the nerves, which is realized with the axonal transport participation.
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D003078:Colchicine / Q000494:pharmacology*; D003714:Denervation; D005930:Glossopharyngeal Nerve / Q000187:drug effects*; D051381:Rats; D013650:Taste Buds / Q000166:cytology*
D003078:Colchicine
Morfometricheskoe izuchenie vkusovykh pochek iazyka krysy posle applikatsii kolkhitsina na iazykoglotochnyĭ nerv.