title: Treatment of advanced seminoma with pre-radiation chemotherapy.
abstract: Seminoma is one of the most radiosensitive of solid tumors. However, the survival rate of patients with clinically advanced stages B3 and C disease is poor. Because of this dismal prognosis we instituted a protocol of pre-radiation chemotherapy in an attempt to improve the survival rates. A chemotherapeutic regimen, consisting of 2 to 3 courses of vincristine, actinomycin D and cyclophosphamide, was administered before radiotherapy. Of 16 patients studied 15 (93.7 per cent) had a complete response to the combined treatment regimen. We believe that pre-radiation chemotherapy is indicated in all patients with advanced seminoma.
mesh_terms: D000328:Adult; D000368:Aged; D003520:Cyclophosphamide / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D004407:Dysgerminoma / Q000188:drug therapy* / Q000532:radiotherapy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D003609:Dactinomycin; D014750:Vincristine; D003520:Cyclophosphamide