Formation of the active antifertility metabolite of (S)-alpha-chlorohydrin in boar sperm.
The male antifertility agent (S)-alpha-chlorohydrin (I) is metabolized by boar sperm to (S)-3-chlorolactaldehyde (II) by an enzyme that is involved in the oxidation of glycerol to glyceraldehyde. The presence of glycerol decreases the activity of this enzyme towards (S)-alpha-chlorohydrin in vitro thereby preventing the formation of (S)-3-chlorolactaldehyde, an inhibitor of glyceraldehyde 3-phosphate dehydrogenase in boar sperm.
D000818:Animals; D002728:Chlorohydrins / Q000378:metabolism*; D003272:Contraceptive Agents, Male / Q000378:metabolism*; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors; D005990:Glycerol / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D013094:Spermatozoa / Q000201:enzymology*; D013552:Swine; D000517:alpha-Chlorohydrin / Q000378:metabolism*
D002728:Chlorohydrins; D003272:Contraceptive Agents, Male; D000517:alpha-Chlorohydrin; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D005990:Glycerol