Cimetidine-theophylline complex formation.
Cimetidine forms a complex with theophylline in vitro in both pH 7.4 buffer and human plasma. The increase in the amount of theophylline in solution is about 20% in the buffer system and about 36% in plasma. It is hypothesized that this complex formation may contribute to and be part of the mechanism of the clinically observed decreased theophylline clearance in man in presence of cimetidine.
D055598:Chemical Phenomena; D002621:Chemistry; D002927:Cimetidine / Q000097:blood*; D004347:Drug Interactions; D006146:Guanidines / Q000097:blood*; D006801:Humans; D013806:Theophylline / Q000097:blood*
D006146:Guanidines; D002927:Cimetidine; D013806:Theophylline