title: Control of an outbreak of mouse coccidiosis in a closed colony.
abstract: In 1979 severe coccidiosis occurred within a closed colony of C57bl/6J Bom mice. The coccidiosis caused diarrhoea, weight loss and deaths. Pathogenicity and response to chemotherapy were studied in experimentally infected Bor: CFW1 (SPF) mice. Histological and other studies indicated that infection was caused by more than 1 Eimeria species which have not yet been determined. Treatment with different anticoccidial drugs was unsuccessful, but use of 2 triazinone-derivatives (Bay g 7183, Bay i 9142) added to the food (15 ppm) succeeded in completely eradicating the organisms from the breeding houses. Experimental findings on the sensitivity of the coccidia to other anticoccidial drugs are described.
mesh_terms: D000818:Animals; D003048:Coccidiosis / Q000188:drug therapy / Q000453:epidemiology / Q000662:veterinary*; D004196:Disease Outbreaks / Q000662:veterinary*; D005243:Feces / Q000469:parasitology; D051379:Mice; D008810:Mice, Inbred C57BL; D014227:Triazines / Q000627:therapeutic use
chemical_list: D014227:Triazines; C032645:BAY-g 7138; C036670:toltrazuril