title: Estimating the ascertainment probability from the number of ascertainments per proband.
abstract: Several methods of estimating the ascertainment probability from the distribution of the number of ascertainments per proband have been presented in the literature. Here these methods are compared. The Skellam often gives the best fit, but there are counter examples. The estimate from a Poisson distribution is generally close to the best solution.
mesh_terms: D005260:Female; D005787:Gene Frequency; D005826:Genetics, Medical; D006801:Humans; D008297:Male; D008433:Mathematics; D008957:Models, Genetic; D011336:Probability