title: Progressive vaccinia associated with combined variable immunodeficiency.
abstract: Progressive vaccinia developed in a previously healthy woman following smallpox vaccination and was successfully treated with vaccinia immune human globulin and methisazone. Immunologic evaluation over the next 4 1/2 years revealed evidence for combined variable immunodeficiency with increased numbers of circulating OKT 8 positive (suppressor-cytotoxic T) cells and the virtual absence of OKT 4 positive (helper-inducer T) cells.
mesh_terms: D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000276:immunology; D008875:Middle Aged; D012899:Smallpox / Q000517:prevention & control; D012900:Smallpox Vaccine / Q000009:adverse effects*; D014611:Vaccination / Q000009:adverse effects*; D014615:Vaccinia / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology
chemical_list: D007136:Immunoglobulins; D012900:Smallpox Vaccine