title: The effect of mass on the gastrointestinal absorption of plutonium and neptunium.
abstract: Absorption and retention of plutonium were determined in mice after intragastric administration of either 6 X 10(-4) or 1.5 mg/kg in bicarbonate, citrate, or nitrate media. At the higher concentration, absorption of the citrate was greater than that of the nitrate; at the lower concentration, chemical form was not an important factor in absorption. Concentration and chemical form had much less influence on absorption by the neonatal (versus the adult) rat. The transfer factor (f1) for neonates was between one and two orders of magnitude higher than for adults. Absorption and retention of neptunium were determined in rats and/or mice after intragastric administration at doses ranging from 2.2 X 10(-7) to 43 mg/kg in nitrate solutions of pH 1.5. At the higher concentrations, absorption was 1.5 to 2.7%. For lower concentrations, absorption was 25 to 65 times less. In contrast to results obtained in adult animals, absorption of neptunium by neonates decreased with increasing dose. The data obtained in adult animals suggest that the f1 factor recommended by the ICRP for plutonium should be increased by a factor of 10, but the neptunium f1 factor, in contrast, should be decreased by a factor of 10.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004064:Digestive System / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D005260:Female; D007408:Intestinal Absorption; D051379:Mice; D009405:Neptunium / Q000378:metabolism*; D011005:Plutonium / Q000378:metabolism*; D011247:Pregnancy; D011868:Radioisotopes; D051381:Rats; D011919:Rats, Inbred Strains; D013046:Specific Gravity; D014018:Tissue Distribution
chemical_list: D011868:Radioisotopes; D011005:Plutonium; D009405:Neptunium