[Effect of antioxidants on lipid peroxidation in combined lesions of the liver].
Experiments on white rats were made to examine the action of sodium selenite alone and combined with tocopherol acetate (vitamin E) as well as that of a tincture prepared from the grass of the selenium-containing plant astragal on lipid peroxidation during liver poisoning with carbon tetrachloride and tetracycline combined with ethyl alcohol. It was shown that carbon tetrachloride, ethanol and tetracycline are inducers of lipid peroxidation. Combination of carbon tetrachloride and tetracycline with ethanol leads to the potentiation of their prooxidant effect. Sodium selenite and the tincture from astragal grass inhibit free radical oxidation, which is evidenced by the reduction of the content of malonic dialdehyde and dienic conjugates in the whole blood and liver homogenates.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000378:metabolism*; D005609:Free Radicals; D006519:Hepatitis, Alcoholic / Q000188:drug therapy / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D020887:Selenious Acid; D012643:Selenium / Q000627:therapeutic use; D013752:Tetracycline / Q000008:administration & dosage; D014810:Vitamin E / Q000627:therapeutic use
D000975:Antioxidants; D005609:Free Radicals; D008054:Lipid Peroxides; D010936:Plant Extracts; D014810:Vitamin E; D020887:Selenious Acid; D013752:Tetracycline; D012643:Selenium
Vliianie antioksidantov na perekisnoe okislenie lipidov pri kombinirovannom porazhenii pecheni.