The influence of haemoperfusion on white cells, immunoglobulin concentrations and the complement system in the treatment of intoxications.
The influence of haemoperfusion on some immunological parameters was investigated in a pilot study involving two groups of three patients each. In columns containing cellulose-coated activated charcoal or polystyrene resin a temporary reduction of the total white cell number, particularly involving the segmented and band neutrophils, was demonstrated. Cellulose-coated activated charcoal and, to a lesser extent, polystyrene resin induced activation of the complement system using C3d as a parameter. An appreciable decrease of immunoglobulin or complement levels could not be demonstrated in either column.
D000328:Adult; D000368:Aged; D003165:Complement System Proteins / Q000378:metabolism*; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism*; D007958:Leukocyte Count; D007962:Leukocytes / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D011041:Poisoning / Q000276:immunology / Q000628:therapy*
D007136:Immunoglobulins; D003165:Complement System Proteins