title: Monitoring heparin therapy--a role for the chromogenic assay.
abstract: Heparin therapy was evaluated by simultaneous determinations of the activated partial thromboplastin time (APTT), and plasma heparin levels by chromogenic assay. These tests showed good correlation (r = 0.73) in patients on heparin alone. However, in the presence of concurrent warfarin administration, r fell to 0.37, reflecting an additional warfarin effect upon the APTT. Furthermore, the studies confirmed the increased heparin requirement in patients with pulmonary embolization.
mesh_terms: D001681:Biological Assay; D002863:Chromogenic Compounds; D004151:Dipeptides; D004359:Drug Therapy, Combination; D006493:Heparin / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D010314:Partial Thromboplastin Time; D011655:Pulmonary Embolism / Q000188:drug therapy; D013924:Thrombophlebitis / Q000188:drug therapy; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D002863:Chromogenic Compounds; D004151:Dipeptides; D014859:Warfarin; C021129:S 2238; D006493:Heparin