Histamine release from leucocytes in migraine.
The spontaneous histamine release (SHR) from leucocytes in migraine patients during symptom-free periods has been investigated, and also the influence of migraine sufferer serum on histamine release (HR) from blood donor leucocytes. The leucocytes were isolated according to the Day method and histamine assay was made by the Shore spectrofluorometric method modified by Bergendorff and Uväs (1). SHR in the 17 female migraine patients was significantly higher (39.7% +/- 13.1%) than in 8 controls (25.4% +/- 4.2%). Migraine serum increased HR from blood donor leucocytes by 14.6% +/- 20.2% compared with the SHR of these cells.
D000328:Adult; D005260:Female; D006632:Histamine / Q000097:blood*; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood*
D006632:Histamine