Cyclic adenosine-3':5'-monophosphate binding proteins in human mammary tumor cytosol and their relation to estrogen and progesterone receptors. A preliminary study.
A method for determining cAMP-binding activity in human mammary tumor cytosol is described and the results of routine assay on 57 tumor samples are presented in relation to the estrogen and progesterone receptor levels. Results show that the values of each single parameter are very largely dispersed. The estrogen receptor/cAMP-binding protein ratio distributes in a very interesting way, in view of a retrospective clinical trial now in progress.
D001943:Breast Neoplasms / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D002373:Cyclic AMP Receptor Protein; D003600:Cytosol / Q000378:metabolism*; D005260:Female; D006801:Humans; D007700:Kinetics; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*
D002352:Carrier Proteins; D002373:Cyclic AMP Receptor Protein; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone