Chromosome instability in a calf affected by congenital malformation.
High rates of structural chromosome aberrations were associated with increased yields of sister chromatid exchanges (SCE) in metaphase chromosomes of a new born female calf affected by a congenital malformation. The frequency of abnormal cells was 25 per cent in the abnormal calf, 8 per cent in its dam and 3 per cent in a group of four healthy cows. Chromatid and chromosome breaks were the most frequent types of chromosome aberration found in the malformed calf; centric fusions, chromosome fragments and deletions were much less common. The mean rate of SCE/cell in the malformed calf was nearly twice that of the control and the difference was statistically significant. Possible factors involved in the occurrence of such a malformation are discussed.
D000818:Animals; D000831:Animals, Newborn / Q000235:genetics*; D002417:Cattle; D002418:Cattle Diseases / Q000151:congenital / Q000235:genetics*; D002869:Chromosome Aberrations / Q000235:genetics / Q000662:veterinary*; D025063:Chromosome Disorders; D003582:Cytogenetics; D005260:Female; D012854:Sister Chromatid Exchange