title: Comparison of fenoterol, isoproterenol, and isoetharine with phenylephrine aerosol in asthma.
abstract: The bronchodilator effect of fenoterol hydrobromide (0.5, 1.25, and 2.5 mg) was compared with either isoproterenol (2.8 mg) or isoetharine (5 mg) with phenylephrine (1.25 mg) in a double-blind placebo-controlled study. When delivered by an intermittent positive-pressure breathing device to 24 nonsmoking young adult asthmatic subjects, fenoterol produced significant improvement in forced expiratory volume at 1 second (FEV1), in maximum midexpiratory flow (FEF25-75%), and in forced expiratory flow at 25 per cent of vital capacity (FEF25%) for 6 to 8 hours, whereas isoproterenol and isoetharine with phenylephrine produced improvement for 1 and 2 hours, respectively. The lowest dosage of fenoterol was as effective as the highest but had fewer adverse effects.
mesh_terms: D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000605:Amino Alcohols / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D005280:Fenoterol / Q000627:therapeutic use*; D005541:Forced Expiratory Volume; D006801:Humans; D007223:Infant; D007528:Isoetharine / Q000627:therapeutic use*; D007545:Isoproterenol / Q000627:therapeutic use*; D008297:Male; D008448:Maximal Expiratory Flow Rate; D010656:Phenylephrine / Q000627:therapeutic use*
chemical_list: D000336:Aerosols; D000605:Amino Alcohols; D004983:Ethanolamines; D010656:Phenylephrine; D005280:Fenoterol; D007545:Isoproterenol; D007528:Isoetharine