title: Lanolin allergy: crisis or comedy.
abstract: Lanolin has been applied to human skin from at least Egyptian times. Its virtues as an emollient and vehicle for cosmetics and drugs have been extolled for centuries. 50 years ago, a fly was found in the ointment--the first case of lanolin allergy was reported (1). Since then lanolin has achieved considerable notoriety as a contact sensitizer. Dozens of articles in the dermatologic literature emphasize the high frequency of lanolin allergy. European dermatologists seem to have become especially sensitized to lanolin allergy. Medical students learn early on, that medicaments in lanolin bases are hazardous. Every novice knows that lanolin is a sensitizer! The nadir of lanolin's fall from grace has been reached in advertisements of topical drugs which emphasize the absence of lanolin in the vehicle. These denouncements by dermatologists have not slowed down the demand for lanolin. About 2 billion pounds of finished cosmetics contain lanolin or its derivatives. It is impossible to reconcile this expanding market with the apprehensions of skin doctors. It is my intention to review the history of lanolin allergy, to present experimental data on its contact sensitizing potential and to put the risk of lanolin allergy in perspective.
mesh_terms: D000438:Alcohols / Q000633:toxicity; D000485:Allergens; D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology*; D006801:Humans; D007809:Lanolin / Q000633:toxicity*; D012306:Risk; D014885:Waxes / Q000633:toxicity; D014935:Wool / Q000633:toxicity
chemical_list: D000438:Alcohols; D000485:Allergens; D014885:Waxes; D007809:Lanolin