[Comparative study of the activity of anti-arrhythmia agents in calcium chloride-induced arrhythmia in mice].
Calcium chloride (280 mg/kg intravenously) provokes arrhythmia, heart fibrillation and death of mice. Pretreatment with isoptin, etmozine, lidocaine, trimecaine, quinidine and novocainamide prevents rhythm disorders and animals' death. Isoptin, etmozine, lidocaine and trimecaine have been found the most effective. Atropine does not produce any protective action. The simplicity and availability of the method described enables one to apply it as a model for search of new antiarrhythmic drugs.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use* / Q000633:toxicity; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D002122:Calcium Chloride / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice
D000889:Anti-Arrhythmia Agents; D002122:Calcium Chloride
Sravnitel'noe izuchenie aktivnosti antiaritmicheskikh sredstv pri khloridkal'tsievoĭ aritmii u mysheĭ.