Phenylenebis(oxy)bis[2,2-dimethylpentanoic acid]s: agents that elevate high-density lipoproteins.
A series of phenylenebis(oxy)bis[2,2-dimethylpentanoic acid]s have been synthesized and evaluated as potential hypolipidemic agents. Compound 18 (CI-924) was found to be the most potent compound in this series. In rats, compound 18 not only reduced low-density lipoprotein cholesterol but also increased high-density lipoprotein (HDL) cholesterol. Comparative studies in rats indicated 18 produced an equal elevation of HDL cholesterol at one-third of the dose required of gemfibrozil. Structure-activity relationships are discussed.
D000818:Animals; D001681:Biological Assay; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015248:Gemfibrozil / Q000031:analogs & derivatives*; D000960:Hypolipidemic Agents / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D010421:Pentanoic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D014631:Valerates / Q000138:chemical synthesis*
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D007202:Indicators and Reagents; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D010421:Pentanoic Acids; D014631:Valerates; C038574:CI 924; D002784:Cholesterol; D015248:Gemfibrozil