Failure of DMSO and vitamin E to prevent doxorubicin skin ulceration in the mouse.
Doxorubicin (DOX)-induced skin ulceration in rats and pigs has been reported to be reduced when treated with topical DMSO and/or vitamin E. In the present study using a mouse model, neither intradermal nor topical DMSO with or without vitamin E, administered up to 7 days, reduced intradermal DOX-induced skin ulceration. Intradermal DMSO with or without vitamin E caused skin ulceration and significantly increased DOX-induced ulcerations. Topical DMSO-containing solutions were not toxic to mouse skin. To test for a systemic effect of topical DMSO, two groups of mice received an additional 0.05-mg intradermal injection of DOX above a DMSO-treated lesion. There was no apparent effect of topical DMSO with or without vitamin E on this proximal but untreated DOX lesion. The results suggest either a major difference in DOX ulceration characteristics between rats and pigs on the one hand and mice on the other hand or a lack of significant efficacy for DMSO and vitamin E as DOX extravasation antidotes.
D000287:Administration, Topical; D000818:Animals; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004317:Doxorubicin / Q000009:adverse effects*; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D008954:Models, Biological; D012883:Skin Ulcer / Q000139:chemically induced* / Q000517:prevention & control; D014810:Vitamin E / Q000494:pharmacology*
D014810:Vitamin E; D004317:Doxorubicin; D004121:Dimethyl Sulfoxide