Time course relation between neurotoxic effects of kainic acid on behaviour and brain GABA-levels. Protection by gamma-vinyl GABA.
Administration of kainic acid (KA, 11 mg/kg i.p.) to rats produced a syndrome of abnormal behaviour (hyperexcitability, stereotypies, convulsions, aphagia and aggressivity) as well as a reduction in brain GABA levels during the first days after treatment. Pretreatments of rats with gamma-vinyl GABA (900 mg/kg) elevated brain GABA levels and prevented the occurrence of convulsions and aphagia. The findings suggest that KA neurotoxicity is due in part to its disruptive effects on GABA neurotransmission.
D000614:Aminocaproates / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D007608:Kainic Acid / Q000633:toxicity*; D008297:Male; D011759:Pyrrolidines / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D020888:Vigabatrin; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000614:Aminocaproates; D011759:Pyrrolidines; D005680:gamma-Aminobutyric Acid; D020888:Vigabatrin; D007608:Kainic Acid