[Long-term course of primary vascular pulmonary hypertension with and without intake of appetite depressants].
1. The long-term follow-up of 22 patients with anorectic drug intake (aminorex fumarate) (AS) and PVPH is compared to 38 patients with PVPH of unknown etiology. 2. The 10-year cumulative survival rate is significantly higher for the AF-positive group (54 +/- 11%) than for the AF-negative patients (15 +/- 6%). 3. In terms of the hemodynamic parameters at the time of diagnosis, there were no differences between the two patient groups. 4. Hemodynamic serial controls in the AF-positive group often show a decrease in pulmonary pressure at rest, in contrast to the AF-negative group. However, in all but one of the patients with a pressure drop at rest there is a considerable increase in pulmonary pressure during exercise. 5. In neither group any correlation is to be found between pulmonary pressure and survival time.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000635:Aminorex / Q000009:adverse effects* / Q000031:analogs & derivatives; D001067:Appetite Depressants / Q000009:adverse effects*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010080:Oxazoles / Q000009:adverse effects*; D011651:Pulmonary Artery / Q000473:pathology; D011652:Pulmonary Circulation / Q000187:drug effects
D001067:Appetite Depressants; D010080:Oxazoles; D000635:Aminorex; C006559:aminorex fumarate
Langzeitverlauf der primär vaskulären pulmonalen Hypertonie mit und ohne Einnahme von Appetitzüglern.