Eye movements in Friedreich's ataxia.
Twenty-four patients with well-documented Friedreich's ataxia underwent quantitative oculomotor testing. A consistent pattern of eye movement abnormalities was observed. This pattern included fixation instability, inaccurate saccades with normal peak velocity, impaired smooth pursuit and optokinetic slow phases, decreased vestibulo-ocular reflex gain, and impaired visual-vestibular interaction. This pattern corresponds to the known pathologic changes of Friedreich's ataxia and can be useful in the differential diagnosis of cerebellar atrophy.
D000293:Adolescent; D000328:Adult; D005123:Eye / Q000503:physiopathology; D005133:Eye Movements; D005260:Female; D005621:Friedreich Ataxia / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009760:Nystagmus, Physiologic; D012018:Reflex / Q000502:physiology; D014724:Vestibular Function Tests; D014787:Vision Tests