Vasopressin analog delays extinction of classically conditioned bradycardia.
Albino rabbits were subjected to Pavlovian (classical) conditioning and extinction of concomitant heart rate and eyeblink responses. Sixty minutes before each of three extinction sessions animals were treated with 5 or 20 micrograms/kg of deamino-dicarba-arginine-8-vasopressin or saline. Vasopressin treatment delayed extinction of bradycardiac conditioned responses but did not affect concomitant eyeblink conditioned responses. It was concluded that classically conditioned autonomic responses may be useful tools for studying the effects of peptides on learning.
D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives* / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects*; D005108:Extinction, Psychological / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D011817:Rabbits
D001127:Arginine Vasopressin; C036166:argipressin, Asu(1,6)-