title: IgG and IgE circulating immune complexes, total serum IgE and parasite related IgE in patients with mono- or mixed infection with Schistosoma mansoni and/or S. haematobium. Influence of therapy.
abstract: IgG and IgE containing circulating immune complexes (CIC), total serum IgE and parasite related IgE were determined in monoinfected patients with Schistosoma mansoni or S.haematobium and in patients with a mixed infection. IgE- and IgG-CIC and total serum IgE were significantly higher in the mixed infection group. There is considerable cross-reactivity between the crude S.haematobium and S.mansoni antigen preparations. The level of IgE-CIC is correlated to the levels of total serum IgE and parasite related IgE respectively. Furthermore IgE-CIC levels were related to the intensity of infection. Twelve out of 21 patients suffering from a monoinfection were reinvestigated 1-4 months after specific chemotherapy. Parasitological cure is followed by a significant decrease of total serum IgE and IgE-CIC, whereas parasite related IgE did not change significantly. The importance of the disappearance of IgE-CIC is discussed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000918:Antibody Specificity; D000936:Antigen-Antibody Complex / Q000032:analysis*; D000941:Antigens / Q000276:immunology; D002648:Child; D003429:Cross Reactions; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis / Q000378:metabolism*; D007074:Immunoglobulin G / Q000378:metabolism*; D008297:Male; D010073:Oxamniquine / Q000627:therapeutic use; D010270:Parasite Egg Count; D012548:Schistosoma haematobium / Q000276:immunology; D012550:Schistosoma mansoni / Q000276:immunology; D012552:Schistosomiasis / Q000188:drug therapy / Q000276:immunology*; D014236:Trichlorfon / Q000627:therapeutic use
chemical_list: D000936:Antigen-Antibody Complex; D000941:Antigens; D007074:Immunoglobulin G; D010073:Oxamniquine; D007073:Immunoglobulin E; D014236:Trichlorfon