Evidence for interactions between [3H]glutamate and [3H]kainic acid binding sites in rat striatal membranes. Possible relevance for kainic acid neurotoxicity.
In vitro studies have shown that kainic acid (10(-6) M) but not N-methyl-D-aspartate (NMDA) in the same concentration reduces the number of striatal [3H]glutamate binding sites and increases their affinity in striatal membranes. In vitro studies also show that L-glutamate (10(-8) M) but not NMDA (10(-6) M) increases the number of [3H]kainic acid binding sites and reduces their affinity in striatal membranes. Ibotenic acid (10(-6) M) can also reduce the affinity of [3H]kainic acid binding sites in striatal membranes. These results give indications for the existence of bidirectional receptor-receptor interactions between two receptors for excitatory amino acids in local striatal circuits. These interactions could partly explain the involvement of glutamate in kainate neurotoxicity.
D000818:Animals; D001665:Binding Sites; D003342:Corpus Striatum / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism*; D066298:In Vitro Techniques; D007608:Kainic Acid / Q000378:metabolism* / Q000633:toxicity; D008297:Male; D008566:Membranes / Q000378:metabolism; D009420:Nervous System / Q000187:drug effects*; D011759:Pyrrolidines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014316:Tritium
D005971:Glutamates; D011759:Pyrrolidines; D014316:Tritium; D007608:Kainic Acid