Parathyroid hormone: effects of the 3-34 fragment in vivo and vitro.
The biologically active fragment ofparathyroid hormone, consisting of residues 1-34, and its in vitro antagonist, fragment 3-34, were administered separately or in combination to chronically thyroparathyroidectomized dogs. These fragments were also studied in vitro with dog renal cortical membranes. Fragment 3-34 inhibited the stimulation of adenylate cyclase by fragment 1-34 in vitro, but had no agonist or antagonistic effects on renal phosphate transport in vivo.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D004285:Dogs; D005260:Female; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000201:enzymology; D010281:Parathyroid Hormone / Q000494:pharmacology*; D010710:Phosphates / Q000652:urine; D013965:Thyroidectomy
D010281:Parathyroid Hormone; D010710:Phosphates; D000262:Adenylyl Cyclases