Total GABA and homocarnosine in CSF as indices of brain GABA concentrations.
Treatment of rats with gamma-vinyl-GABA, an inhibitor of GABA-transaminase, caused a dose- and time-related increase in brain GABA concentrations concomitant with increases in the concentrations of total GABA and homocarnosine in the CSF. At 18 h after treatment both CSF parameters correlated significantly with brain GABA concentrations. However, only total GABA in CSF accurately reflected brain GABA concentrations as a function of time after treatment and is therefore the preferred index.
D000614:Aminocaproates / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002336:Carnosine / Q000031:analogs & derivatives / Q000134:cerebrospinal fluid*; D004151:Dipeptides / Q000134:cerebrospinal fluid*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D020888:Vigabatrin; D005680:gamma-Aminobutyric Acid / Q000134:cerebrospinal fluid*
D000614:Aminocaproates; D004151:Dipeptides; C005038:homocarnosine; D005680:gamma-Aminobutyric Acid; D002336:Carnosine; D020888:Vigabatrin