Synthesis and biological activity of polyriboadenylic acid: polyribo-5-dimethylaminouridylic acid hybrid (poly(A): poly(Me2N5U)).
Poly-5-dimethylaminouridylic acid, (poly(Me2N5U)) has been synthesized by the conversion of 5-bromouridine-5'-monophosphate to 5-dimethylaminouridine-5'-monophosphate which was later made into the 5'-diphosphate and subsequently polymerized by PNPase. The polymer formed a 1:1 hybrid with poly(A) with the ability to induce the production of interferon in chick embryoes as certain doses of the hybrid protected chick embryoes against wesselsbron virus (H 10964).
D000818:Animals; D002642:Chick Embryo; D006207:Half-Life; D006868:Hydrolysis; D007369:Interferon Inducers / Q000138:chemical synthesis*; D011063:Poly A-U / Q000138:chemical synthesis* / Q000494:pharmacology; D011117:Polyribonucleotide Nucleotidyltransferase / Q000378:metabolism; D012260:Ribonucleases / Q000378:metabolism
D007369:Interferon Inducers; D011063:Poly A-U; C038215:polyriboadenylic acid-polyribo-5-dimethylaminouridylic acid; D011117:Polyribonucleotide Nucleotidyltransferase; D012260:Ribonucleases