Antioxidant properties of caeruloplasmin towards iron- and copper-dependent oxygen radical formation.
The antioxidant activity of caeruloplasmin can be mainly ascribed to its ferroxidase activity which effectively inhibits ferrous ion-stimulated lipid peroxidation and ferrous ion-dependent formation of hydroxyl radicals in the Fenton reaction. In addition, caeruloplasmin can prevent copper ions from stimulating lipid peroxidation.
D000818:Animals; D000975:Antioxidants; D002417:Cattle; D002570:Ceruloplasmin / Q000378:metabolism*; D003300:Copper / Q000494:pharmacology; D003855:Deoxyribose / Q000378:metabolism; D005609:Free Radicals; D066298:In Vitro Techniques; D007501:Iron / Q000494:pharmacology; D008054:Lipid Peroxides / Q000378:metabolism*
D000975:Antioxidants; D005609:Free Radicals; D008054:Lipid Peroxides; D003855:Deoxyribose; D003300:Copper; D007501:Iron; D002570:Ceruloplasmin