title: Prevention of hereditary large bowel cancer: tissue culture assays and logistics.
abstract: It is currently believed that normal genes, presumably in the class of tissue differentiation genes (proto-oncogenes), are responsible for the malignant transformation of human cells. As such, they cannot be appropriately used to identify individuals at risk for cancer. Based on our experience with a cell system from patients with adenomatosis of the colon and rectum (ACR), we suggest that predisposition to cancer can best be detected as a global syndrome at the phenotypic level. The ability to distinguish a cancer predisposed person from a normal individual in well-defined populations should qualify a test as "cancer specific". An underlying assumption in these studies is that predisposition to cancer, in general, is associated with an autosomal dominant trait in obligatory heterozygote gene carriers.
mesh_terms: D000199:Actins / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009858:Oncogenic Viruses; D012004:Rectal Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D000199:Actins; D013755:Tetradecanoylphorbol Acetate