title: [Primary structure of alpha and beta chains from the major hemoglobin component of the magpie goose (Anseranas semipalmata, Anatidae)].
abstract: The amino acid sequence of the alpha and beta chains from the major hemoglobin component (HbA) of Australian Magpie Goose (Anseranas semipalmata) is given. The minor component with the alpha D chains was detected, but only found in low concentrations. By homologous comparison, Greylag Goose hemoglobin (Anser anser) and Australian Magpie Goose alpha chains differ by 13 amino acids or 17 nucleotide (4 two point mutations) exchanges, beta chains by 6 exchanges. Seven alpha 1 beta 1 contacts are modified by substitutions in positions alpha 30-(B11)Glu leads to Gln, alpha 34(B15)Thr leads to Gln, alpha 35(B16)-Ala leads to Thr, alpha 36(B17)Tyr leads to Phe, beta 55(D6)Leu leads to Ile, beta 119(GH2)Ala leads to Ser and beta 125(H3)Glu leads to Asp. Further, one alpha 1 beta 2 contact point was changed in beta 39(C5)Gln leads to Glu. Mutation in this position, except in two abnormal human hemoglobins, was not found in any species. Amino acid exchanges between hemoglobin of Australian Magpie Goose and other birds are discussed.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005777:Geese / Q000097:blood*; D006454:Hemoglobins / Q000235:genetics; D006455:Hemoglobins, Abnormal; D006801:Humans; D046911:Macromolecular Substances; D009154:Mutation; D010446:Peptide Fragments / Q000032:analysis; D013045:Species Specificity
chemical_list: D006454:Hemoglobins; D006455:Hemoglobins, Abnormal; D046911:Macromolecular Substances; D010446:Peptide Fragments
vernacular_title: Die Primärstruktur der alpha- und beta-Ketten der Hauptkomponente der Hämoglobine der Spaltfussgans (Anseranas semipalmata, Anatidae).