title: The morphogenesis of a papillomatous gastric polyp in the crab-eating monkey (Macaca fascicularis).
abstract: The histopathology of gastric papillomas in 17 crab-eating monkeys from Indonesia and Malaysia was investigated. The changes in the affected mucosa consisted of papillomatous proliferation with accidental heterotopia, desquamation or necrosis of the epithelium associated with eggs or adults of the small nematode Nochtia nochti, inflammatory cell infiltration and haemorrhage or oedema and fibrosis. The primary pathogenic effect of this parasite was due to its irritant action on the gastric mucosa. Hyper-regeneration, with a downward shift of the proliferating zone in the gastric gland and an inflammatory process, appeared to play a significant role in the morphogenesis of this lesion. It is concluded that the gastric papilloma associated with Nochtia nochti in the monkey is a parasitic inflammatory polyp.
mesh_terms: D000818:Animals; D005753:Gastric Mucosa / Q000473:pathology; D008252:Macaca fascicularis; D008992:Monkey Diseases / Q000469:parasitology*; D009349:Nematode Infections / Q000662:veterinary*; D011127:Polyps / Q000469:parasitology / Q000662:veterinary*; D013274:Stomach Neoplasms / Q000469:parasitology / Q000662:veterinary*