Higher fibrinolytic activity in human endometrium in direct contact with an IUD.
From 18 apparently healthy women wearing a copper-IUD, endometrial biopsy specimens were obtained under hysteroscopic control, both from the site of the IUD and from a distant area. The fibrinolytic activity proved significantly higher in the former specimens than in the latter. The results provide a theoretical basis for the development of an IUD which releases a synthetic inhibitor of fibrinolysis.
D004717:Endometrium / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D007435:Intrauterine Devices, Copper / Q000009:adverse effects*