Carcinogenicity and toxicity tests on p-phenylenediamine in F344 rats.
p-Phenylenediamine, an intermediate of oxidative-type hair dyes, was administered to groups of male and female F344 rats in their diet. A subacute toxicity test showed that 0.4% p-phenylenediamine was very toxic to both sexes, but that 0.2, 0.1 and 0.05% p-phenylenediamine induced no remarkable toxic changes in either sex. In a chronic toxicity test 0.1 and 0.05% p-phenylenediamine were given to both sexes in their diet for 80 weeks, but no carcinogenic effects were found in either sex.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D005260:Female; D006202:Hair Dyes / Q000633:toxicity*; D006203:Hair Preparations / Q000633:toxicity*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010084:Oxidation-Reduction; D010655:Phenylenediamines / Q000633:toxicity*; D011230:Precancerous Conditions / Q000139:chemically induced; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors
D002273:Carcinogens; D006202:Hair Dyes; D006203:Hair Preparations; D010655:Phenylenediamines; C029728:4-phenylenediamine