Survival of carrier erythrocytes in splenectomized calves.
Carrier erythrocyte survival was investigated in intact and splenectomized calves. Survival curves for both were biphasic, with a characteristic early loss of 10% to 15% of the carrier cells in intact calves followed by a half-life of 22 to 24 days. In splenectomized calves, 50% to 75% of the carrier cells disappeared from circulation in the first 24 hours. The 2nd phase of survival showed a 44-day half-life for the remaining carrier cells. Erythrocytes from splenectomized calves appeared to be permeable to [14C]sucrose and were more susceptible to irreversible hemolysis from the dialysis encapsulation procedure. Blood volume determination showed a 22% decrease after splenectomy.
D000818:Animals; D001810:Blood Volume; D001811:Blood Volume Determination / Q000662:veterinary; D002417:Cattle / Q000097:blood*; D002463:Cell Membrane Permeability; D004905:Erythrocyte Aging; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000166:cytology / Q000378:metabolism; D006207:Half-Life; D009996:Osmotic Fragility; D013154:Spleen / Q000502:physiology; D013156:Splenectomy / Q000662:veterinary*; D013395:Sucrose / Q000378:metabolism
D013395:Sucrose