Experimental evidence for concentration-dependent plasma protein binding effects on the apparent half-lives of restrictively cleared drugs.
D001798:Blood Proteins / Q000378:metabolism*; D004206:Disopyramide / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D006801:Humans; D008657:Metabolic Clearance Rate; D009961:Orosomucoid / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011485:Protein Binding
D001798:Blood Proteins; D009961:Orosomucoid; D004364:Pharmaceutical Preparations; D004206:Disopyramide