[Pharmacological correction of cerebral circulation in experimental acute myocardial ischemia].
In acute experiments on anesthetized cats myocardial ischemia led to a reduction of the total brain circulation because of the increased resistance of brain vessels and lowered perfusion pressure. After administering curantyl, euphylline and nonachlazine myocardial ischemia brought about less pronounced decrease of the total brain circulation largely at the expense of elimination of brain vessels constriction. After administering strophanthine alone or combined with curantyl myocardial ischemia did not lead to any essential alterations in brain blood supply. It is likely that strophanthine and curantyl recover the compensatory mechanisms of the brain vessels lost during acute myocardial ischemia.
D000628:Aminophylline / Q000008:administration & dosage; D000818:Animals; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004176:Dipyridamole / Q000008:administration & dosage; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D009628:Nonachlazine / Q000008:administration & dosage; D013328:Strophanthins / Q000008:administration & dosage; D014655:Vascular Resistance / Q000187:drug effects
D002317:Cardiovascular Agents; D013328:Strophanthins; D000628:Aminophylline; D004176:Dipyridamole; D009628:Nonachlazine
Farmakologicheskaia korrektsiia krovoobrashcheniia mozga pri éksperimental'noĭ ostroĭ ishemii miokarda.