[Safety evaluation of micronomicin. II. Irritation by repeated intravenous injection in dogs].
Micronomicin (MCR) is a new aminoglycoside antibiotic produced by Micromonospora sagamiensis var. nonreducans which was isolated from soil collected at Sagamihara by Nara et al. The purified antibiotic showed a close similarity to gentamicin C complex in physical and chemical properties. The antibacterial activity of MCR is broad-spectrum and almost equal to that of gentamicin C complex. MCR exhibits particularly high activity against Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia, etc. and high activity against some Pseudomonas aeruginosa strains resistant to gentamicin C1a. A study on the irritation by repeated intravenous injection in dogs was carried out for safety evaluation (Doses: 4, 10, 25, 63 mg/kg and 100 mg/kg). Bleeding, edema, vasculitis and perivasculitis were observed at injection sites both in physiological saline-treated controls and MCR-treated groups. But irritation attributable to MCR was not observed at any dose.
D000617:Aminoglycosides / Q000008:administration & dosage / Q000009:adverse effects; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005839:Gentamicins; D007275:Injections, Intravenous; D007509:Irritants; D014657:Vasculitis / Q000139:chemically induced; D014680:Veins / Q000187:drug effects*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D007509:Irritants; C037545:micronomicin