Enhanced natriuretic effect of ADH in rats loaded with NaCl.
ADH at doses 20 microU/100 g and 100 microU/100 g or 20 microU/100 g and 200 microU/100 g was injected intravenously into pentobarbital and alcohol anaesthetized rats loaded with either water or isotonic solution consisting of NaCl, glucose and ethanol. At the dose of 20 microU/100 g ADH retained water in both water and NaCl loaded animals. At high doses 100 microU/100 g in NaCl loaded rats and 200 microU/100 g in water loaded rats, ADH retained water and increased the renal excretion of Na+. That the natriuretic effect of ADH at the dose 20 microU/100 g was enhanced in NaCl loaded rats suggests that ADH is probably important in the regulation of Na+ content in the body when it is loaded with NaCl.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007552:Isotonic Solutions; D009318:Natriuresis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000494:pharmacology*; D014667:Vasopressins / Q000494:pharmacology*
D007552:Isotonic Solutions; D014667:Vasopressins; D012965:Sodium Chloride