Topological analysis of the reovirus type 3 hemagglutinin.
We previously showed that the reovirus type 3 hemagglutinin (HA) has distinct functional domains. For example, we identified one group of anti-HA monoclonal antibodies which only inhibited virus-mediated hemagglutination and another group which exclusively neutralized reovirus infectivity. Using competition radioimmunoassays, we now report that these functionally discrete domains on the reovirus type 3 HA correspond to discrete antigenic regions of the protein.
D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D006389:Hemagglutinins, Viral / Q000032:analysis*; D012089:Mammalian orthoreovirus 3 / Q000032:analysis*; D011863:Radioimmunoassay; D012087:Reoviridae / Q000032:analysis*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D006389:Hemagglutinins, Viral