Retinoblastoma in Navajo Indian children.
Retinoblastoma occurs with an observed incidence of one in 18,000 live births, and 35% to 45% of cases are transmitted genetically in a dominant fashion. A retrospective analysis of Navajo Indian children during the past 15 years disclosed an incidence 21/2 to three times the expected. This observation raises the possibility that silent expression of the gene for retinoblastoma occurs more frequently among the Navajo population compared with the population at large.
D002648:Child; D002675:Child, Preschool; D005134:Eye Neoplasms / Q000453:epidemiology* / Q000235:genetics; D006801:Humans; D007198:Indians, North American; D007223:Infant; D012175:Retinoblastoma / Q000453:epidemiology* / Q000235:genetics; D012189:Retrospective Studies; D014481:United States