Effect of experimental anaemia on red cell GSH and enzyme activities in guinea-pig and rabbit.
1. The effect of experimental anaemia on red cell GSH and enzyme activities of GSH-Px, GSSG-R and G6PD was investigated in guinea-pig and rabbit. 2. The anaemia was induced by injection of PHH in guinea-pig and rabbit and also by bleeding in guinea-pig. 3. Red cell GSH increased from 115.5 to 141.8 mg/dl RBC in the guinea-pig and from 108.5 to 133.5 mg/dl RBC in the rabbit during anaemia. 4. There were significant rises in the level of all the three enzymes activities in both the species of animals. However, the changes in rabbit were more pronounced than in the guinea-pig.
D000740:Anemia / Q000201:enzymology* / Q000209:etiology; D000818:Animals; D001815:Bloodletting; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005978:Glutathione / Q000097:blood*; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006168:Guinea Pigs; D008297:Male; D010659:Phenylhydrazines; D011817:Rabbits; D013045:Species Specificity
D010659:Phenylhydrazines; C030299:phenylhydrazine; D005954:Glucosephosphate Dehydrogenase; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione