title: Respiratory disease among workers exposed to man-made mineral fibers.
abstract: Fibrous glass and mineral wool workers exposed to airborne man-made mineral fibers prior to 1964 were identified and followed for deaths caused by respiratory disease. Fiber exposure levels were estimated for each worker. Average fiber concentrations were very low in relation to a National Institute of Occupational Safety and Health recommendation that exposure to man-made mineral fibers less than 3.5 microns in diameter be limited to 3 fibers per cubic centimeter of air. Fibrous glass workers were exposed to about one hundredth and mineral wool workers to about one tenth of that amount. Respiratory cancer death rates were not excessive for the fibrous glass workers, but they were significantly elevated for the mineral wool workers. When respiratory cancer deaths were compared with fiber exposure levels, however, there was in no instance a strong positive correlation. There was a significant excess in nonmalignant respiratory disease deaths (excluding influenza and pneumonia) for fibrous glass workers and for the total cohort. When these nonmalignant respiratory disease deaths were compared with fiber exposure levels, however, there was in no instance a strong positive association. A special study was made of workers exposed to small diameter fibers. Respiratory cancer deaths were not in excess; however, there was an excess in nonmalignant respiratory disease deaths. This study provided no consistent evidence of a respiratory disease hazard related to exposure to man-made mineral fibers among the workers who produce these fibers. Results must be interpreted in relation to the relatively low exposure levels for these workers.
mesh_terms: D000328:Adult; D017610:Calcium Compounds; D005898:Glass; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000009:adverse effects*; D009784:Occupational Diseases / Q000139:chemically induced / Q000453:epidemiology* / Q000401:mortality; D010316:Particle Size; D012140:Respiratory Tract Diseases / Q000139:chemically induced / Q000453:epidemiology* / Q000401:mortality; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000401:mortality; D017640:Silicates; D012824:Silicic Acid / Q000009:adverse effects; D013997:Time Factors; D014481:United States
chemical_list: D017610:Calcium Compounds; D008903:Minerals; D017640:Silicates; C009753:fiberglass; D012824:Silicic Acid; C031293:calcium silicate