title: [Effectiveness of prophylactic irradiation of the cervical lymphatics in malignant tumors of the nasopharynx].
abstract: The effectiveness of prophylactic irradiation of areas of the neck commonly involved in metastatic spread was studied in 276 patients with nasopharyngeal malignancies who were followed up during 5 and more years. The analysis was carried using such criteria as the decrease in the frequency of recurrent regional metastases, distant metastases and increase in 5-year survival. The absorbed doses ranged 45-50 Gy. The procedure was followed by a decrease in the frequency of regional metastases (3.4% versus 32.7% in untreated patients). The frequency of distant metastases decreased nearly by half (19.5% versus 31.7%). Five-year survival rates increased significantly from 49 to 65.5%. This relationship was recorded for all histological types of tumors. Application of prophylactic irradiation in doses of 45-50 Gy prevents local subclinical metastasis development in most patients.
mesh_terms: D005069:Evaluation Studies as Topic; D006801:Humans; D008207:Lymphatic Metastasis; D008208:Lymphatic System / Q000528:radiation effects*; D009303:Nasopharyngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D009333:Neck; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage
vernacular_title: Effektivnost' profilakticheskogo oblucheniia limfaticheskikh puteĭ shei pri zlokachestvennykh opukholiakh nosoglotki.