title: Improvement of skin flap survival by local injections of Regitine and propranolol. An experimental study in the rat.
abstract: An increase in the surviving area of skin flaps was achieved by local injections of alpha-adrenergic and beta-adrenergic blocking agents. Dorsal skin flaps of albino rats were injected postoperatively at their bases with Regitine (Ciba-Geigy, Switzerland), propranolol and a combination of these two drugs, two or three times daily for 6 days. All the pharmacologically treated animals showed a significantly better flap survival rate than did the control group (P less than 0.001). More frequent injections gave increasing flap survival areas. However, a combination of the above-mentioned drugs did not improve the results when compared with propranolol administered alone, and was less effective than Regitine administered alone.
mesh_terms: D000818:Animals; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D010646:Phentolamine / Q000008:administration & dosage* / Q000494:pharmacology; D011433:Propranolol / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013524:Surgical Flaps
chemical_list: D004338:Drug Combinations; D011433:Propranolol; D010646:Phentolamine