Intraluminal hexadecane enhances large intestinal excretion of tissue hexachlorobenzene in rats.
In young adult female rats with a cecal stoma, administration of hexadecane into the stomach (750 or 500 mg) and into the ligated colon (250 mg) enhanced 2- to 3-fold the intestinal excretion of [14C]hexachlorobenzene. Apparent sites of increased transferral from the blood into luminal contents were (caudal) ileum, cecum and colon. Presence of nonabsorbed hexadecane in luminal contents seems to be a prerequisite for the effect. Results support previous reports that enhancement of intestinal excretion of lipophilic chemicals by liquid paraffins takes place in the large intestine.
D000473:Alkanes / Q000494:pharmacology*; D000818:Animals; D002432:Cecum / Q000378:metabolism; D002722:Chlorobenzenes / Q000378:metabolism*; D003106:Colon / Q000378:metabolism; D005260:Female; D006581:Hexachlorobenzene / Q000378:metabolism*; D007420:Intestine, Large / Q000187:drug effects / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism; D008026:Ligation; D051381:Rats; D011919:Rats, Inbred Strains
D000473:Alkanes; D002722:Chlorobenzenes; D006581:Hexachlorobenzene; C007932:n-hexadecane