title: Chronic mild restraint protects the rat gastric mucosa from injury by ethanol or cold restraint.
abstract: The effects of chronic mild restraint on the susceptibility of the rat gastric mucosa to ethanol or cold-restraint injury were studied. Gastric mucosas of animals subjected to chronic mild restraint exhibited less damage when bathed with 40% ethanol than those of control animals. This reduced damage was observed with 2 days of mild restraint and was maximal (93% less damage; p less than 0.0005) when the animal was mildly restrained for 10 days. Pretreatment with indomethacin abolished the protection afforded by chronic mild restraint, suggesting a mechanism involving endogenous prostaglandin synthesis. Chronic mild restraint significantly (p less than 0.05) reduced the injury to the gastric mucosa caused by cold-restraint stress. This model of mild restraint may prove useful in future studies on the mechanism of stress-induced and other gastric mucosal lesions.
mesh_terms: D000818:Animals; D003080:Cold Temperature; D004594:Electrophysiology; D000431:Ethanol; D005753:Gastric Mucosa / Q000378:metabolism* / Q000473:pathology; D005790:General Adaptation Syndrome / Q000503:physiopathology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009336:Necrosis; D011453:Prostaglandins / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000503:physiopathology*
chemical_list: D011453:Prostaglandins; D000431:Ethanol; D007213:Indomethacin