title: [Cytogenetic action of the pesticides captan and benomyl in a lymphocyte culture of human peripheral blood in the absence and presence of a system of metabolic activation].
abstract: Results of the investigation of mutagenic effects of fungicides captan and benomyl in the culture of human peripheral lymphocytes in vitro with and without metabolic activation showed that captan did not manifest cytogenetic activity in any experimental variants, while benomyl induced colchicine-like and weak clastogenic effect in the concentration 10 micrograms/ml in the presence of microsomal activating mixture only.
mesh_terms: D000328:Adult; D001542:Benomyl / Q000494:pharmacology*; D002215:Captan / Q000494:pharmacology*; D002219:Carbamates / Q000494:pharmacology*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008861:Microsomes / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects; D009152:Mutagenicity Tests
chemical_list: D002219:Carbamates; D003520:Cyclophosphamide; D002215:Captan; D001542:Benomyl
vernacular_title: Issledovanie tsitogeneticheskogo deĭstviia pestitsidov kaptana i benomila v kul'ture limfotsitov perifericheskoĭ krovi cheloveka v otsutstvie i pri nalichii sistemy metabolicheskoĭ aktivatsii.