[Mechanism of the diuretic action of parathormone].
The effect of parathyroidin, calcium chloride and parathyroidin combined with verapamil (blocking the inclusion of calcium ions into cells) on diuresis and electrolyte excretion with the urine was studied in experiments on dogs. It was shown that after a single intravenous injection of parathyroidin in a dose of 2 U/kg body weight diuresis and natriuresis twice augmented and potassium excretion increased 1.6 times one hour following the drug injection. The intravenous injection of 10% calcium chloride solution or parathyroidin combined with verapamil did not produce such an effect. The mechanism of parathyroid hormone diuretic action is likely to be due to intensified calcium ion inclusion into the renal tubular cells.
D000818:Animals; D002122:Calcium Chloride / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects*; D004285:Dogs; D005260:Female; D008297:Male; D010281:Parathyroid Hormone / Q000494:pharmacology*; D012079:Renal Circulation / Q000187:drug effects; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology; D014882:Water-Electrolyte Balance / Q000187:drug effects
D010281:Parathyroid Hormone; D014700:Verapamil; D002122:Calcium Chloride
K mekhanizmu diureticheskogo deĭstviia paratgormona.