Platelet-derived growth factor stimulates bone resorption by monocyte monolayers.
Resorption of devitalized bone particles by monocytes grown in culture was stimulated by platelet-derived growth factor (PDGF) in a dose-dependent manner. Bone resorption in response to PDGF was time-dependent with a significant increase over control cultures evident by 72 hours. These data are the first to demonstrate stimulation of bone resorption by PDGF in a specific cell type known to resorb bone in vivo and in vitro.
D001862:Bone Resorption / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism*; D010455:Peptides / Q000494:pharmacology*; D010982:Platelet-Derived Growth Factor; D013997:Time Factors
D006133:Growth Substances; D010455:Peptides; D010982:Platelet-Derived Growth Factor