The role of nicotinic receptors in dog pancreatic exocrine secretion.
1 The effects of pentamethonium, an autonomic ganglion blocker, were studied on the exocrine pancreatic secretion of six conscious dogs given intravenous infusions of urecholine, caerulein or pentagastrin on a background of submaximal doses of secretin. 2 Urecholine-induced protein secretion was not affected but both caerulein- and to a smaller extent, pentagastrin-induced protein secretions were depressed by pentamethonium. 3 These results indicate that intravenous caerulein and pentagastrin, but not urecholine, act at least partially via nicotinic receptors. 4 Volume and bicarbonate output were depressed by pentamethonium when stimulated by intravenous caerulein with a background of secretin, but not when stimulated by pentagastrin on a background of secretin. 5 From these data it is suggested that caerulein and pentagastrin may potentiate secretin-stimulated hydrelatic secretion by different mechanisms.
D000818:Animals; D001626:Bethanechol Compounds / Q000494:pharmacology; D002108:Ceruletide / Q000494:pharmacology; D004285:Dogs; D005731:Ganglionic Stimulants / Q000494:pharmacology; D007273:Injections, Intramuscular; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D010418:Pentagastrin / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000378:metabolism*; D013997:Time Factors
D001626:Bethanechol Compounds; D005731:Ganglionic Stimulants; D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic; D002108:Ceruletide; D010418:Pentagastrin