Effect of two dopamine agonists, TL-99 and 3-PPP, on prolactin secretion in the rat.
TL-99 and 3-PPP, two putative dopamine autoreceptor agonists, effectively suppressed serum prolactin (PRL) concentrations in rats treated with alpha-methyltyrosine. In addition, the secretion of PRL from anterior pituitary tissue under in vitro conditions was significantly inhibited by TL-99 and 3-PPP. These findings are supportive of the view that TL-99 and 3-PPP exert a dopamine agonist action at dopamine receptors in the anterior pituitary gland.
D000818:Animals; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D010903:Pituitary Gland, Anterior / Q000502:physiology; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000502:physiology; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D009281:Naphthalenes; D010880:Piperidines; D011954:Receptors, Dopamine; D013764:Tetrahydronaphthalenes; C016893:2-(N,N-dimethylamino)-6,7-dihydroxytetralin; D011388:Prolactin; C026539:preclamol