Familial carcinoma of ureters and other genitourinary organs.
We report on a woman, her mother and her mother's cousin who had papillary transitional cell carcinoma of the ureter associated with other cancers of the genitourinary tract. Neoplasms in these family members may be due to interactions between host susceptibility factors and exposure to environmental carcinogens. Studies of peripheral blood karyotype and urine mutagenic activity yielded normal results.
D000368:Aged; D002274:Carcinogens, Environmental; D002295:Carcinoma, Transitional Cell / Q000235:genetics*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D014516:Ureteral Neoplasms / Q000235:genetics*; D001749:Urinary Bladder Neoplasms / Q000235:genetics; D014594:Uterine Neoplasms / Q000235:genetics
D002274:Carcinogens, Environmental