[Primary multiple malignant tumors associated with bladder cancer].
Of 487 patients with urothelial bladder cancer seen during the past 22 years, 37 (7.6%) had other primary malignant tumors. In recent years the number of patients with double cancer markedly increased. The male/female ratio was 2.7:1 and the mean age at the time of diagnosis of the second primary cancer was 70 (56-84) years. Of the other organ cancers, 18 (47%) were in the digestive tract and 7 (18%) in the respiratory tract. Six patients had lesions that were diagnosed simultaneously and 31 had lesions that were diagnosed at intervals. The interval in 31 patients with metachronous double cancer ranged from 1 year and 1 month to 40 years; the mean interval was 9 years and 7 months.
D000367:Age Factors; D000368:Aged; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000453:epidemiology; D006801:Humans; D007564:Japan; D008175:Lung Neoplasms / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology*; D012737:Sex Factors; D012907:Smoking; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology*