Action of cocaine on norepinephrine- and calcium-induced contraction of vascular smooth muscle.
The action of cocaine on the norepinephrine- and calcium-induced contraction of the thoracic aorta and the main pulmonary artery of the rabbit was studied. Cocaine, depending on the employed concentrations, shows a competitive or a non-competitive antagonism against norepinephrine, while, against calcium, cocaine, at the used concentrations, shows a competitive antagonism. The results are discussed in the light of literature data obtained from different preparations of several animal species. It is clear that the actions of local anesthetics must be evaluated through a wide range of doses and by considering the properties of the biological object.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D011817:Rabbits; D012701:Serotonin / Q000494:pharmacology; D013748:Tetracaine / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects*
D013748:Tetracaine; D012701:Serotonin; D003042:Cocaine; D002118:Calcium; D009638:Norepinephrine