The enhancement of cyclosporin A-induced nephrotoxicity by gentamicin.
Normal rats receiving treatment with either cyclosporin A or gentamicin show dose-dependent nephrotoxicity, the changes with cyclosporin A centering on the straight segment of the proximal tubule, while gentamicin affects the convoluted segment. When the two drugs are given together, nephrotoxicity is enhanced with significant reductions in renal function even at therapeutic dosage. The study emphasises the caution needed when potentially nephrotoxic agents are administered in combination.
D000118:Acetylglucosaminidase / Q000652:urine; D000818:Animals; D003404:Creatinine / Q000097:blood; D003524:Cyclosporins / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005839:Gentamicins / Q000633:toxicity*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014508:Urea / Q000097:blood
D003524:Cyclosporins; D005839:Gentamicins; D014508:Urea; D003404:Creatinine; D000118:Acetylglucosaminidase