Effect on cerebral D-[3H]aspartate release of 3-mercaptopropionic acid and methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate.
Minislices of rat brain cortex were preloaded with D-[3H]aspartate and spontaneous and potassium-induced (25 mM KCl) efflux of labelled compound into superfusate measured. 3-Mercaptopropionic acid, 100-220 microM did not modify the spontaneous efflux of D-[3H]aspartate, but augmented the K+-induced efflux. Methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate, 10 or 100 microM, enhanced both spontaneous and K+-induced efflux of D-[3H]aspartate. The convulsant action of both compounds may be due to enhanced synaptic release of aspartate or a related excitatory neurotransmitter.
D015097:3-Mercaptopropionic Acid / Q000494:pharmacology*; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002243:Carbolines / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D013438:Sulfhydryl Compounds
D002243:Carbolines; D007211:Indoles; D013438:Sulfhydryl Compounds; C034818:methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate; D001224:Aspartic Acid; D011189:Potassium Chloride; D015097:3-Mercaptopropionic Acid