Effect of cimetidine on the pharmacokinetics of quinidine and lidocaine in the rat.
Because of previously reported drug interactions involving cimetidine and liver-metabolized drugs, the intravenous pharmacokinetics of quinidine (25 mg/kg) and lidocaine (15 mg/kg) were investigated in anesthetized rats pretreated with a single intraperitoneal dose of cimetidine (60 mg/kg) and compared with saline pretreated controls. Significant reductions of 35 and 23% in the respective total clearances of quinidine and lidocaine were observed in the presence of cimetidine. The quinidine volume of distribution was significantly decreased in the cimetidine-treated rats, while the lidocaine volume of distribution was not altered significantly. There was no significant change in the elimination half-life for either drug in the presence of cimetidine. These results suggest cautious use of quinidine or lidocaine when cimetidine is prescribed concurrently.
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D004347:Drug Interactions; D006146:Guanidines / Q000494:pharmacology*; D007700:Kinetics; D008012:Lidocaine / Q000378:metabolism*; D008297:Male; D011802:Quinidine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D006146:Guanidines; D002927:Cimetidine; D008012:Lidocaine; D011802:Quinidine