title: Butriptyline: improved gas-liquid chromatographic method using a nitrogen-phosphorus detector for its determination in serum.
abstract: We report a sensitive and specific method for the determination of butriptyline concentrations in serum by gas-liquid chromatography with a nitrogen phosphorus detector. The detection limit is 2 ng/ml, based on 3 ml of serum or plasma. The method has been validated in human volunteers receiving a single oral dose of 75 mg butriptyline hydrochloride.
mesh_terms: D002849:Chromatography, Gas / Q000379:methods; D003986:Dibenzocycloheptenes / Q000097:blood*; D006801:Humans
chemical_list: D003986:Dibenzocycloheptenes; C100242:butriptyline