Effect of apomorphine, piribedil and haloperidol on adrenal ornithine decarboxylase activity of the rat.
The administration of the dopaminergic drugs, apomorphine and piribedil to rats resulted in an increase in the activity of ornithine decarboxylase of the adrenal medulla and cortex. Pretreatment of the rats with the dopamine-receptor antagonist haloperidol caused a partial blockade of the apomorphine-induced effect at 4 hr in both medulla and cortex. At 6 hr, however, haloperidol did not block the effect of apomorphine and produced an increase in ornithine decarboxylase activity of both structures when administered alone. Hypophysectomy abolished the cortical ornithine decarboxylase response to apomorphine and haloperidol and the medullary response to haloperidol. The results suggest that the response of cortical ornithine decarboxylase activity to apomorphine and haloperidol is entirely mediated by the hypophysis and that the effect of apomorphine and the antagonistic action of haloperidol towards apomorphine in regard to the induction of adrenal medullary ornithine decarboxylase must be taking place at some central site independent of the hypothalamic-hypophyseal system.
D000311:Adrenal Glands / Q000201:enzymology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D002262:Carboxy-Lyases / Q000378:metabolism*; D002940:Circadian Rhythm; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology*; D007016:Hypophysectomy; D008297:Male; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D010879:Piperazines / Q000494:pharmacology*; D010891:Piribedil / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical
D010879:Piperazines; D010891:Piribedil; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase; D006220:Haloperidol; D001058:Apomorphine