[Pharmacologic influencing of fetal phospholipid synthesis. Part IV: influencing the DPL(dipalmitoyl-lecithin) content of fetal lung by betamethasone (author's transl)].
Dipalmitoyllecithinic (DPL) is the quantitatively largest and most active portion of the surfactant system. Hence only a quantitative DPL determination allows a relevant statement of fetal lung maturity. The antenatal prophylaxis of RDS should result in an increase of the DPL-level in a fetal lung. A new gaschromatographical method for determination of DPL was developed. The results were secured by gaschromatography-mass-spectrometry-couplings. After treatment with betamethasone an increase of the relative DPL-amount in fetal rat lung lecithin species was found, but not an increase of the lecithin-level in the lung-tissue. Corticosteroids probably induce transesterification of the lecithins.
D000818:Animals; D001623:Betamethasone / Q000494:pharmacology*; D002849:Chromatography, Gas; D005325:Fetal Organ Maturity / Q000187:drug effects*; D008168:Lung / Q000187:drug effects / Q000196:embryology*; D010743:Phospholipids / Q000096:biosynthesis*; D011663:Pulmonary Surfactants / Q000032:analysis / Q000494:pharmacology*; D051381:Rats
D010743:Phospholipids; D011663:Pulmonary Surfactants; D001623:Betamethasone
Pharmakologische Beeinflussung der fetalen Phospholipidsynthese Teil IV: Beeinflussung des pulmonalen DPL-(Dipalmitoyl-Lezithin)-Spiegels durch Betamethason.