Nephropathy induced in rats by repeated intravenous injections of rabbit anti-FX1A antibody.
Repeated intravenous injections of small amounts of rabbit anti-rat FXIA antibodies (RAFA) induced a renal damage with the morphological features of epimembranous glomerulonephritis with significant and persistent proteinuria. These findings indicated that repeatedly injected RAFA accumulated in glomeruli and that there seems to be a threshold in quantity of RAFA localized in glomeruli to induce renal damage with proteinuria.
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000936:Antigen-Antibody Complex; D000941:Antigens / Q000276:immunology*; D005260:Female; D007674:Kidney Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D008297:Male; D011507:Proteinuria / Q000209:etiology; D011817:Rabbits; D051381:Rats
D000906:Antibodies; D000936:Antigen-Antibody Complex; D000941:Antigens; C035812:renal tubular antigen