Mullerian inhibiting substance inhibits colony growth of a human ovarian carcinoma cell line.
Mullerian inhibiting substance (MIS), a fetal testicular product which causes regression of the Mullerian duct in the male mammalian embryo, is being evaluated as an inhibitor of genital tract tumors. The present study demonstrates in a clonogenic soft agar that biologically active MIS inhibits the growth of a human ovarian carcinoma cell line (HOC-21) in a dose-dependent manner when compared to phosphate-buffered saline medium controls, heat-inactivated MIS, or biochemical fractions which lack biological activity (P less than 0.05).
D054304:Anti-Mullerian Hormone; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D005260:Female; D006023:Glycoproteins; D006131:Growth Inhibitors; D006801:Humans; D008297:Male; D009095:Mullerian Ducts / Q000032:analysis*; D010051:Ovarian Neoplasms / Q000378:metabolism*; D011247:Pregnancy; D013735:Testicular Hormones / Q000302:isolation & purification* / Q000494:pharmacology*
D006023:Glycoproteins; D006131:Growth Inhibitors; D013735:Testicular Hormones; D054304:Anti-Mullerian Hormone