[Plasma levels of desmethylclomipramine and clomipramine at steady-state in the morning. Correlative analysis and prediction of theoretical blood clomipramine].
Clomipramine (CMI) was administered to eight patients, either as an antidepressive drug or, in two patients, as an antalgic drug (average age: 54 y.; average body surface area: 1,71 m2). These patients were treated with 20 to 150 mg, every day, for various lengths of time: min.; one week: max.; 7 years, till the day before the determination of plasma levels. The samples were drawn on patients, fasting, in the morning. Plasma levels of CMI, Desmethylclomipramine (DCMI) and Cortisol were dosed by means of High Performance Liquid Chromatography with U. V. detection.
D000328:Adult; D000368:Aged; D002940:Circadian Rhythm; D002997:Clomipramine / Q000031:analogs & derivatives* / Q000097:blood* / Q000627:therapeutic use; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged
C012273:desmethylclomipramine; D002997:Clomipramine; D006854:Hydrocortisone
Taux plasmatiques de desméthylclomipramine et de clomipramine au "steady-state', le matin. Analyse corrélative et prévision d'une clomipraminémie théorique.