Immunoreactive met-enkephalin in the canine adrenal; response to acute hypovolemic stress.
Immunoreactive met-enkephalin was measured in the adrenal, kidney, liver, and intestine of the dog using radioimmunoassay. Adrenal tissue concentrations were 20 to 200-fold higher than the other tissues studied. In response to acute hypovolemic stress, the concentration of met-enkephalin in the adrenal vein of the dog increased 6-fold over basal peripheral arterial levels. These results suggest that the canine adrenal gland is a rich source of this opioid peptide and that the adrenal releases met-enkephalin in response to acute stress.
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D004285:Dogs; D004744:Enkephalin, Methionine / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D011863:Radioimmunoassay; D012769:Shock / Q000378:metabolism*; D013312:Stress, Physiological / Q000378:metabolism*
D004744:Enkephalin, Methionine