[ATP effects on eccito-conduction and arterial pressure before and after block of the vagus. Haemodynamic and electrophysiologic study (author's transl)].
In order to investigate the cardiovascular effects of ATP (15-30 mg) i.v. administration, 12 normal subjects, aged 27-55 yrs, were studied, during Arterial Pressure Monitoring and His Bundle Electrogram recording, using Sherlag's technique. ATP cardiovascular response was divided in the following four phases: Latency phase, Progressive Bra dyarrhythmic-Hypotensive, Maximal Inhibitor Phase, Tachyarrhytthmic Hypotensive Reflex Phase. Atropine (0.02-0.04 mg/Kg) i.v. injection did not significantly prevent ATP effects. Increasing dosage of atropine (0,06, pointed out a moderate competitive antagonism with ATP. These data suggest a possible direct action of ATP (purinergic receptors or direct membrane effect) but don't exclude an interaction with Parasympathetic system (probable purinergic neuromodulation).
D000255:Adenosine Triphosphate / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D001285:Atropine / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects*; D004347:Drug Interactions; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011955:Receptors, Drug / Q000187:drug effects; D011983:Receptors, Purinergic
D011955:Receptors, Drug; D011983:Receptors, Purinergic; D001285:Atropine; D000255:Adenosine Triphosphate
L'azione dell'ATP sull'eccito-conduzione e sulla P.A. prima e dopo blocco del vago. Studio elettrofisiologico ed emodinamico.