DSIP/DSIP-P and circadian motor activity of rats under continuous light.
Daily intravenous injection of 30 nmol/kg DSIP (delta sleep-inducing peptide) in rats under constant illumination produced marked changes of their motor activity as compared to saline controls. Similar marked but distinctly different effects on the circadian pattern of locomotor behavior partially abolished by constant illumination were also obtained after repeated administration of 0.1 nmol/kg DSIP-P (the phosphorylated analogue of DSIP) which enhanced overall motor activity. In both instances the results additionally differed from those reported for a normal 12 hr light:dark cycle. The present results support the hypothesis that DSIP might primarily act by influencing circadian rhythmicity.
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects* / Q000528:radiation effects; D003701:Delta Sleep-Inducing Peptide; D008027:Light; D009043:Motor Activity / Q000187:drug effects*; D009842:Oligopeptides / Q000494:pharmacology*; D010766:Phosphorylation; D051381:Rats
D009842:Oligopeptides; D003701:Delta Sleep-Inducing Peptide