title: Elastic tissue changes in skin following PUVA therapy.
abstract: Treatment of psoriasis with psoralens and high-intensity long-wave ultraviolet light (PUVA) produces changes in the ultrastructure of elastic tissue in skin. Early alterations consist of a loss of elastin followed by a breakdown of the microfibrils and subsequent fragmentation of the elastic fiber. Tissue examined 15 months after treatment was stopped still showed marked ultrastructural changes in the elastic fibers.
mesh_terms: D004547:Elastic Tissue / Q000187:drug effects* / Q000648:ultrastructure; D004549:Elastin / Q000032:analysis; D011564:Furocoumarins / Q000494:pharmacology*; D010778:Photochemotherapy; D011565:Psoriasis / Q000188:drug therapy; D012867:Skin / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D011564:Furocoumarins; D004549:Elastin