[Characteristics of the development of model psychosis in rats in intracerebral administration of lysergic acid diethylamide].
Chronic experiments on rats with a microcannula implanted into the brain were made to study the effect of diethylamide of lisergic acid (DLA) on spontaneous behavior, locomotion and emotional behavioral reactions. Administration of DLA into the lateral brain ventricles and mesencephalic reticular formation demonstrated that the action of DLA becomes manifest in extremely low doses and within the narrow dose range. The action of DLA is biphasic in nature: the first phase is noted for increased locomotion, while the second one for inhibition. The development of the first phase is linked with a direct effect of DLA on the mesencephalic reticular formation which appeared sensitive to the drug action. It is suggested that the effect of DLA on the central nervous system is realized with the aid of the triggering mechanism.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D006801:Humans; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D008297:Male; D011605:Psychoses, Substance-Induced / Q000209:etiology*; D051381:Rats; D012154:Reticular Formation
D008238:Lysergic Acid Diethylamide
O nekotorykh osobennostiakh razvitiia model'nogo psikhoza u krys pri intratserebral'nom vvedenii diétilamida lizerginovoĭ kisloty.