title: Effects of lasalocid or monensin on legume or grain (feedlot) bloat.
abstract: Doses of .66 to .99 mg monensin/kg body weight reduced legume bloat in cattle about 66% when compared with pretreatment bloat scores. Similar doses of lasalocid reduced legume bloat about 26%. A dose of 44 mg poloxalene/kg body weight (recommended dose for field use) reduced legume bloat 100%. Monensin or lasalocid combined with 25 or 50% of the recommended dose of poloxalene reduced bloat under that of the antibiotics alone, but did not achieve 100% reduction. The antibiotic thiopeptin provided no preventive effect on legume bloat. Lasalocid, monensin or an experimental polyether antibiotic (X-14,547 A) at a dose of 1.32 mg/kg body weight when tested on cattle bloated on high grain diets reduced bloat by 92, 64 and 25%, respectively. Lasalocid at .66 mg/kg effectively prevented bloat from developing when given to animals before the feeding of high grain diets; however, a 1.32-mg dose was required to control bloat in cattle that were already bloating before they were given lasalocid. A dose of 1.32 mg salinomycin was ineffective in controlling grain bloat.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D023181:Antimicrobial Cationic Peptides; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D004198:Disease Susceptibility; D004359:Drug Therapy, Combination; D002523:Edible Grain / Q000009:adverse effects*; D007887:Fabaceae / Q000009:adverse effects*; D005260:Female; D005663:Furans / Q000627:therapeutic use*; D007192:Indenes / Q000627:therapeutic use; D007832:Lasalocid / Q000627:therapeutic use*; D008985:Monensin / Q000627:therapeutic use*; D010455:Peptides / Q000627:therapeutic use; D010946:Plants, Medicinal; D011060:Poloxalene / Q000627:therapeutic use; D012417:Rumen; D013272:Stomach Diseases / Q000517:prevention & control / Q000662:veterinary*
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D005663:Furans; D007192:Indenes; D010455:Peptides; C022076:thiopeptin; C023605:X 14547-A; D011060:Poloxalene; D008985:Monensin; D007832:Lasalocid