title: Peroral xylitol increases the concentration levels of tissue iron in the rat.
abstract: The effect of xylitol feeding on the iron content of rat tissues was studied. Adult male rats were fed on the basal diet containing (g/kg) 200 glucose, or 50 or 200 xylitol, or the same diet containing no added carbohydrates for 8 weeks. Each feeding group comprised nine animals. Xylitol at 200 g/kg diet retarded the growth rate of the rats, whereas 200 g glucose/kg increased the weight gains compared with animals given no added carbohydrates. Xylitol at 50 g/kg did not affect the tissue Fe concentrations, but 200 g xylitol/kg increased the Fe content of the livers, duodenum wall, spleen, bone marrow and serum. Cadmium and lead contents of the livers were similar in all groups. Xylitol-Fe complexes are suggested to be responsible for the increased Fe absorption during xylitol feeding.
mesh_terms: D000042:Absorption; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D005947:Glucose / Q000494:pharmacology; D007501:Iron / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution / Q000187:drug effects; D014993:Xylitol / Q000494:pharmacology*
chemical_list: D007501:Iron; D005947:Glucose; D014993:Xylitol