title: The influence of aluminium on parathyroid hormone levels in haemodialysis patients.
abstract: In order to investigate the relationship between parathyroid hormone (PTH) and aluminium we studied 86 haemodialysis patients whom we separated into three groups according to their serum PTH values. Group I: PTH less than 600ng/L; Group II: PTH 600-900ng/L; Group III: PTH greater than 900ng/L. A significant difference was found between Groups I and III in the serum aluminium (Group I: 4.85 mumol/L; Group III: 2.84 mumol/L, p less than 0.003) and serum calcium (Group I: 2.43mmol/L; Group III: 2.32mmol/L, p less than 0.0125). The association of higher serum aluminium and calcium with lower PTH concentrations suggests that aluminium can suppress PTH release through an elevation of the serum calcium.
mesh_terms: D000293:Adolescent; D000328:Adult; D000535:Aluminum / Q000097:blood / Q000494:pharmacology*; D000536:Aluminum Hydroxide / Q000627:therapeutic use; D002118:Calcium / Q000097:blood; D006801:Humans; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000037:antagonists & inhibitors / Q000097:blood*; D006435:Renal Dialysis; D013997:Time Factors
chemical_list: D010281:Parathyroid Hormone; D000536:Aluminum Hydroxide; D000535:Aluminum; D002118:Calcium