title: [Monoclonal antibodies to digestive-tract cancer].
abstract: There have been few reports concerning monoclonal antibodies to human digestive-tract cancers and CEA. Recently, we established several monoclonal antibodies to either gastric cancer, colorectal cancer or CEA using a CEA-secreting gastric cancer cell line or a purified CEA preparation as immunogen. In this review, we mainly described serologic and molecular characterization of both CEA-related and CEA-unrelated antigens detected by the monoclonal antibodies originated in our laboratory. We also introduced some approaches to the clinical application of the monoclonal antibodies described in the literature.
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology* / Q000302:isolation & purification; D002272:Carcinoembryonic Antigen / Q000276:immunology; D003110:Colonic Neoplasms / Q000276:immunology*; D006801:Humans; D013274:Stomach Neoplasms / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen