[Acid secretion and serum gastrin during acute and chronic treatment with pirenzepine in duodenal ulcer (author's transl)].
In 8 outpatients with duodenal ulcer the effect of a single dose of 50 mg pirenzepine is compared to a 3-7 days treatment with 2x50 mg. Basal and peptone-stimulated acid output is measured. A single dose of 50 mg pirenzepine reduced basal acid output by 39,9% and the stimulated acid secretion by 21,3%. Treatment for 3-7 days with 2x50 mg pirenzepine is significantly more effective. Basal acid output is reduced by 75,1% and stimulated acid output by 54,0%. No acid inhibition can be demonstrated 12 hours after the last drug administration. Basal serum gastrin levels are little but significantly increased after chronic treatment.
D000284:Administration, Oral; D001570:Benzodiazepinones / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004381:Duodenal Ulcer / Q000097:blood / Q000188:drug therapy*; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood*; D006801:Humans; D010879:Piperazines / Q000627:therapeutic use*; D010890:Pirenzepine
D001570:Benzodiazepinones; D005755:Gastrins; D010879:Piperazines; D010890:Pirenzepine
Säuresekretion und Serumgastrinspiegel nach einmaliger und mehrtägiger Gabe von Pirenzepin beim Ulcus duodeni.