Inactivation of cytochrome P-450 and production of N-alkylated porphyrins caused in isolated hepatocytes by substituted dihydropyridines. Structural requirements for loss of haem and alkylation of the pyrrole nitrogen atom.
D000818:Animals; D065607:Cytochrome P-450 Enzyme Inhibitors; D003997:Dicarbethoxydihydrocollidine / Q000494:pharmacology; D005294:Ferrochelatase / Q000037:antagonists & inhibitors; D006418:Heme / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D008930:Mitochondria, Liver / Q000201:enzymology; D011166:Porphyrins / Q000378:metabolism*; D011524:Protoporphyrins / Q000378:metabolism*; D013329:Structure-Activity Relationship
D065607:Cytochrome P-450 Enzyme Inhibitors; D011166:Porphyrins; D011524:Protoporphyrins; D006418:Heme; D003997:Dicarbethoxydihydrocollidine; C028842:N-methylprotoporphyrin IX; D005294:Ferrochelatase