Phase II evaluation of galactitol in head and neck cancer: a Southwest Oncology Group Study.
A phase II evaluation of DAG in head and neck cancer patients produced one partial response and one patient with prolonged stable disease from nine fully evaluable patients with squamous carcinomas. One partial response was produced in a patient with anaplastic thyroid carcinoma. No drug deaths or life-threatening toxicity were reported. Further evaluation of DAG in thyroid tumors is warranted.
D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000187:drug effects; D003961:Dianhydrogalactitol / Q000009:adverse effects / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013402:Sugar Alcohols / Q000627:therapeutic use*
D013402:Sugar Alcohols; D003961:Dianhydrogalactitol