Cycloheximide prevents apomorphine-induced yawning, penile erection and genital grooming in rats.
Apomorphine (50 micrograms/kg) induced repeated episodes of yawning, penile erection and genital grooming in rats. A dose of cycloheximide, which inhibited brain protein synthesis by 50% totally prevented apomorphine-induced yawning and reduced by approximately 50% the occurrence of episodes of penile erection and genital grooming. However, this treatment failed to modify the stereotyped behaviour induced by 200 micrograms/kg of apomorphine. These results suggest that protein synthesis is required for the behavioural effects of small doses of apomorphine.
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors*; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000378:metabolism; D003513:Cycloheximide / Q000494:pharmacology*; D006120:Grooming / Q000187:drug effects*; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D010413:Penis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects
D009419:Nerve Tissue Proteins; D003513:Cycloheximide; D001058:Apomorphine