[Experimental studies on the effect of labyrinth anesthesia].
Injection of tetracaine into the tympanic cavity inhibits, independently of histologic lesions of the round window membrane, the active electrogenic pump in the stria vascularis cells. The DC potential in the endolymph is reduced with increasing doses of tetracaine, while the K+-Cl- activity is unchanged for 120 min. This drug does not alter the permeability of Reissner's membrane. Near the stria vascularis area, the oxygen pressure in the endolymph increases significantly after the effects of 4% tetracaine.
D000772:Anesthesia, Local; D000818:Animals; D007758:Ear, Inner / Q000187:drug effects* / Q000648:ultrastructure; D004710:Endolymph / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D010046:Oval Window, Ear / Q000648:ultrastructure; D013748:Tetracaine / Q000494:pharmacology*
D013748:Tetracaine
Experimentelle Untersuchung über die Wirkung der "Labyrinthanästhesie".