[Conditions favoring production and mechanism of action of macrophage pyrogen].
Activation of mononuclear phagocytes by staphylococci in vitro results in the production of endogenous pyrogen. Macrophage pyrogen does not posses species pyrogenic specificity. Intracisternal injection increases pyrogen susceptibility more than 100-fold as compared to intravenous injection. Still more abrupt increase in pyrogen susceptibility was observed in the animals in the presence of elevated body cAMP concentration induced by theophylline preinjection.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D007275:Injections, Intravenous; D007278:Injections, Spinal; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D010537:Peritoneum / Q000166:cytology; D011650:Pulmonary Alveoli / Q000166:cytology; D011749:Pyrogens / Q000008:administration & dosage / Q000096:biosynthesis / Q000494:pharmacology*; D011817:Rabbits; D013045:Species Specificity; D013210:Staphylococcus; D013806:Theophylline / Q000494:pharmacology
D011749:Pyrogens; D013806:Theophylline
Ob usloviiakh polucheniia i mekhanizme deĭstviia makrofagal'nogo pirogena.