title: Obstructive lesions of distal mesenteric arteries. A light and electron microscopic study.
abstract: Two cases of "nonocclusive" intestinal infarction are reported. No thrombosis or significant atherosclerosis was identified and proximal mesenteric arteries were widely patent. However, distal mesenteric arteries were thickened and had pinpoint lumens. Light microscopic findings suggested that this marked luminal narrowing was due to prominent intimal fibromuscular proliferation, medial hypertrophy and mild structural disarray, focal periarterial fibrosis, and transmural elastosis. Electron microscopic findings indicated that the endothelium was normal but the basal lamina was irregularly thickened. The predominant cellular component of the thickened intima consisted of smooth muscle cells, and smooth muscle cells of the media were seen to migrate through an extensively disrupted and degenerated internal elastic lamina. Deposits of young elastic fibers, collagen, and ground substance were also noted, particularly in the intima. The need for careful sectioning and microscopic examination of small distal mesenteric arteries in cases of so-called nonocclusive intestinal infarction is emphasized.
mesh_terms: D000368:Aged; D006801:Humans; D007238:Infarction / Q000209:etiology / Q000473:pathology; D007422:Intestines / Q000098:blood supply / Q000473:pathology; D008297:Male; D008638:Mesenteric Arteries / Q000473:pathology* / Q000648:ultrastructure; D008641:Mesenteric Vascular Occlusion / Q000150:complications / Q000473:pathology*