Leukotrienes C and D induce bronchoconstriction in man.
Pulmonary responses to aerosols of synthetic leukotrienes C and D were examined in two normal volunteers. The leukotrienes were equipotent and equieffective in producing moderate bronchoconstriction accompanied by coughing. Changes in FEV1 were slight, but changes in expiratory flow at low lung volumes were more notable. FPL 55712 abolished the cough response and partially inhibited the bronchoconstriction.
D000328:Adult; D000403:Airway Resistance / Q000187:drug effects*; D001980:Bronchi / Q000187:drug effects*; D002867:Chromones / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013189:SRS-A / Q000494:pharmacology*
D002867:Chromones; D013189:SRS-A; C006312:FPL 55712