Enteral absorption and biotransformation of the food additive octyl gallate in the rat.
Following oral administration of 14C-labelled octyl gallate in a single dose of 15 mg/kg to female rats, only 20-30% of the radioactivity administered was detected in the tissues, while 60-80% of the dose was found in the contents of the gastro-intestinal tract up to 12 hr after administration. Isotope dilution analysis demonstrated the presence of the unchanged ester in the tissues. In the liver, the highest concentration of the ester demonstrated was 1.6 micrograms/g. in a rat killed 10 min after treatment. In the 24 hr following ip administration of labelled octyl gallate, about 91% of the administered radioactivity was recovered. Most of this was in the form of metabolites, only 9% being accounted for as unchanged ester.
D000818:Animals; D001711:Biotransformation; D005260:Female; D005503:Food Additives / Q000378:metabolism*; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D007408:Intestinal Absorption; D008657:Metabolic Clearance Rate; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D005503:Food Additives; C016627:octyl gallate; D005707:Gallic Acid