Antidotes for acute bismuth intoxication.
Nine chelating agents were tested as antidotes for acute bismuth intoxication in mice. Of these, those with sulfhydryl groups, adjacent aromatic hydroxy groups or appropriately positioned phosphonate groups proved themselves to be effective antidotes. Of the compounds currently approved for therapeutic use, D-penicillamine was the most effective.
D000208:Acute Disease; D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001729:Bismuth / Q000506:poisoning*; D002614:Chelating Agents / Q000627:therapeutic use*; D008297:Male; D051379:Mice
D000931:Antidotes; D002614:Chelating Agents; D001729:Bismuth