Syntheses and biological activities of azido ubiquinone derivatives.
A general method for the synthesis of azido-ubiquinone derivatives has been developed directly by substituting one hydrogen atom on the benzoquinone ring with an azido group under weakly acidic conditions. The reaction takes several hours and the yield is generally low. The azido-ubiquinone was purified by preparative thin layer chromatography, and identified by NMR, IR and mass spectra. All the synthesized azido-ubiquinone derivatives show partial activity in mediating biological electron transfer in the dark, and show partial or complete inhibition upon photolysis.
D002855:Chromatography, Thin Layer; D004579:Electron Transport; D009682:Magnetic Resonance Spectroscopy; D010777:Photochemistry; D013053:Spectrophotometry; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000032:analysis / Q000138:chemical synthesis
D014451:Ubiquinone