[In vitro study of the stability of reduced intraerythrocyte glutathione against a group of drugs frequently used during the neonatal period].
Authors have studied in 32 samples of cord blood (normal newborns and normal births) the stability of glutathione reduced form (GSH) in human erythrocytes opposite to ten drugs (gentamicin, cephazolin, amikacin, carbenicillin, amoxicillin, benzodiacepine, metil-prednisolone, phenilbarbituric acid, fosfomycin, trimethroprim-sulphamethoxazole) using it at similar concentration to the highest haemotic levels that are obtained in the newborn with therapeutic doses. They showed that these drugs have not an effect on stability of GSH. For this reason is very unprobable that these drugs are cause of haemolitic crisis in the newborn. In the another hand, they suggest the use co-trimoxazole in the newborn always, in correct doses.
D004355:Drug Stability; D004912:Erythrocytes / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism*; D006400:Hematocrit; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood / Q000188:drug therapy*
D005978:Glutathione
Estudio "in vitro" de la estabilidad del glutation reducido intraeritrocitario, frente a un grupo de fármacos de utilización frecuente en el período neonatal.