Vascular effects of the peptides PYY and PHI: comparison with APP and VIP.
Local infusions of PYY (3-100 pmol.min-1) caused a slowly developing vasoconstriction of a long duration in the cat submandibular salivary gland. The vasoconstrictor action of PYY was also present after alpha-adrenoceptor blockade and in sympathectomized animals. Local APP infusions caused only weak vasoconstriction. Infusions of PHI and synthetic PHI caused an atropine-resistant submandibular vasodilation. On a molar basis PHI was, however, almost 1000-fold less potent than VIP as vasodilating agent.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002415:Cats; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D007269:Injections, Intra-Arterial; D010191:Pancreatic Polypeptide / Q000494:pharmacology*; D010451:Peptide PHI; D019894:Peptide YY; D010455:Peptides / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D013363:Submandibular Gland / Q000098:blood supply; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*; D014665:Vasodilator Agents
D005768:Gastrointestinal Hormones; D010451:Peptide PHI; D010455:Peptides; D014665:Vasodilator Agents; D019894:Peptide YY; D014660:Vasoactive Intestinal Peptide; C009725:pancreatic polypeptide, avian; D010191:Pancreatic Polypeptide; D001285:Atropine