Silver-Russell syndrome. A family with symmetric and asymmetric siblings.
Two siblings with Silver-Russell syndrome (SRS) were studied. Only one child had asymmetry. To our knowledge, this is the first report of the existence of both the "Silver" and "Russell" variants in a nuclear family, and provides additional evidence for considering SRS to be a single syndrome with a wide spectrum of clinical manifestations.
D000015:Abnormalities, Multiple / Q000235:genetics*; D002648:Child; D004392:Dwarfism / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010375:Pedigree; D012600:Scoliosis / Q000235:genetics