Myosin phosphorylation and the cross-bridge cycle in arterial smooth muscle.
Phosphorylation of the 20,000-dalton light chain of myosin is closely correlated with cross-bridge cycling in arterial smooth muscle. Evidence is presented that dephosphorylation can produce an attached, noncycling cross-bridge (latch-bridge) which is responsible for the high economy of force maintenance in this tissue.
D000199:Actins / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000502:physiology; D002339:Carotid Arteries / Q000502:physiology*; D046911:Macromolecular Substances; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000502:physiology*; D009218:Myosins / Q000378:metabolism*; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D013552:Swine
D000199:Actins; D046911:Macromolecular Substances; D011494:Protein Kinases; D009218:Myosins; D002118:Calcium