Enterococcal meningitis: combined vancomycin and rifampin therapy.
Intrathecal vancomycin and oral rifampin have been used together to successfully treat a patient with enterococcal meningitis who was allergic to penicillin and who had failed a course of treatment with chloramphenicol. This therapy was tolerated very well and represents an alternate mode of therapy which should be considered in penicillin allergic patients with enterococcal meningitis.
D000284:Administration, Oral; D002701:Chloramphenicol / Q000627:therapeutic use; D004342:Drug Hypersensitivity; D004359:Drug Therapy, Combination; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008581:Meningitis / Q000188:drug therapy* / Q000209:etiology; D008875:Middle Aged; D010406:Penicillins / Q000009:adverse effects; D012293:Rifampin / Q000008:administration & dosage*; D013290:Streptococcal Infections / Q000188:drug therapy*; D014640:Vancomycin / Q000008:administration & dosage*
D010406:Penicillins; D002701:Chloramphenicol; D014640:Vancomycin; D012293:Rifampin