Vanoxonin, a new inhibitor of thymidylate synthetase.
Vanoxonin, a new inhibitor of thymidylate synthetase, was found in cultured broths of the strain MG245-CF2 classified as Saccharopolyspora hirsuta. Vanoxonin, C18H25N3O9, was obtained as colorless powder. Vanoxonin forms a vanadium complex which exhibits a strong inhibition against thymidylate synthetase. The concentration for 50% inhibition of the enzyme (IC50) was 0.7 micrograms/ml.
D000192:Actinomycetales / Q000032:analysis*; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000201:enzymology; D002413:Cations, Divalent; D004151:Dipeptides / Q000302:isolation & purification / Q000494:pharmacology*; D007700:Kinetics; D008780:Methyltransferases / Q000037:antagonists & inhibitors*; D051379:Mice; D013056:Spectrophotometry, Ultraviolet; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*
D002413:Cations, Divalent; D004151:Dipeptides; C038755:vanoxonin; D008780:Methyltransferases; D013940:Thymidylate Synthase