Antitumor activity of tuftsin on murine melanoma in vivo.
The effect of tuftsin on malignant melanoma was studied in vivo using a murine model system. It was found that tuftsin was capable of significantly reducing the number of tumor colonies appearing in the lungs of mice following iv administration of tumor cells. Although only a limited number of concentrations of tuftsin were used in our preliminary studies, it appears that tuftsin possesses antitumor activity over a wide range of doses.
D000818:Animals; D003114:Colony-Forming Units Assay; D007128:Immunoglobulin Fragments / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary; D008297:Male; D008545:Melanoma / Q000188:drug therapy*; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D009360:Neoplastic Cells, Circulating; D011336:Probability; D013997:Time Factors; D014405:Tuftsin / Q000627:therapeutic use*
D007128:Immunoglobulin Fragments; D014405:Tuftsin