Dietary carbohydrate decreases 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in rat liver.
Diets high in carbohydrate and low in fat led to a decrease in the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of healthy, reverse light-cycled rats. The effect on reductase was due both to a decline in expressed enzyme activity and to a decrease in total number of enzyme molecules. Inhibition of reductase activity was paralleled by a fall in hepatic cholesterolgenesis and by an increase in triglyceride formation. Thus, a reduction in endogenous cholesterol synthesis may explain the serum cholesterol-lowering effect of high carbohydrate, low fat diets in man.
D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis*; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000096:biosynthesis
D004040:Dietary Carbohydrates; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014280:Triglycerides; D002784:Cholesterol