Angiotensin II stimulates phosphatidylinositol turnover in adrenal glomerulosa cells by a calcium-independent mechanism.
Angiotensin II enhances phosphatidylinositol turnover in isolated adrenal glomerulosa cells. In the present experiments we examined whether this effect required the presence of extracellular Ca2+. It was found that neither the stimulation of phosphatidylinositol breakdown nor the stimulation of incorporation of [32P]phosphate into phosphatidic acid and phosphatidylinositol required the presence of extracellular Ca2+. These observations suggest that the enhancement of phosphatidylinositol turnover may precede, but does not depend on, angiotensin-induced Ca2+ influx.
D000302:Adrenal Cortex / Q000378:metabolism*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000502:physiology*; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D008297:Male; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D010716:Phosphatidylinositols; D000804:Angiotensin II; D002118:Calcium