Hypouricemia related to a hypersecretional tubulopathy.
We present 1 patient with hypouricemia and hyperuricosuria. Serum uric acid level ranged between 1.5 and 1.9 mg/dl and uric acid fractional excretion between 20 and 28%. Apart from that the renal function was normal. The pyrazinamide suppression test gave a normal response showing nearly complete suppression of urate excretion. The uricosuric response to sulfinpyrazone was normal too. The renal tubular response to extracellular fluid volume contraction induced by furosemide indicated a normal tubular sensitivity to extracellular fluid volume variations. From these results we conclude that our patient has a specific tubulopathy characterized by uric acid hypersecretion.
D000328:Adult; D003864:Depression, Chemical; D005110:Extracellular Space / Q000502:physiology; D005260:Female; D005665:Furosemide; D006801:Humans; D007677:Kidney Function Tests; D007684:Kidney Tubules / Q000378:metabolism*; D008587:Meningitis, Viral / Q000503:physiopathology; D011718:Pyrazinamide; D013442:Sulfinpyrazone; D014527:Uric Acid / Q000097:blood / Q000378:metabolism* / Q000652:urine
D014527:Uric Acid; D011718:Pyrazinamide; D005665:Furosemide; D013442:Sulfinpyrazone