The effect of propylthiouracil on glutathione S-transferase activity of rat spleen in vitro and in vivo.
Propylthiouracil (PTU) inhibited glutathione (GSH) S-transferase (EC 2.5.1.18) activity of rat spleens in a concentration dependent manner in vitro. PTU (1.5 mmoles/kg) treatment of rats for 1 or 2 weeks caused a decrease in leukocyte number and spleen weight. Nevertheless, GSH S-transferase activity was not affected by the same treatment.
D000818:Animals; D004912:Erythrocytes / Q000201:enzymology; D005982:Glutathione Transferase / Q000378:metabolism*; D007700:Kinetics; D007962:Leukocytes / Q000201:enzymology; D011441:Propylthiouracil / Q000494:pharmacology*; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000201:enzymology*
D011441:Propylthiouracil; D005982:Glutathione Transferase