Comparative cardiac effects of three hepatobiliary radiopharmacologicals in the dog: concise communication.
Three hepatobiliary agents with an acetanilide-imidoacetic-acid moiety resembling that in lidocaine were investigated for their possible effects on contractility and conductivity in the heart and on arterial pressure and aortic blood flow. This was done in the light of lidocaine's numerous cardiac side effects. HIDA, BIDA, and DIPA, each with traces of decayed Tc-99m, were injected i.v. into anesthetized dogs with an A-V block, and their effects on the above parameters were followed until control levels were reestablished. Whereas lidocaine raises the diastolic threshold and prolongs the refractory period, the three agents tested do not prolong myocardial conductivity. Both HIDA and BIDA have an effect similar to that of lidocaine, but DIPA has no effect on the latter two parameters. Moreover, whereas lidocaine depressed myocardial contractility, blood pressure, and blood flow, HIDA has a less prominent effect on these parameters, and neither BIDA nor DIPA has any such effect. It is concluded that even though the effect of HIDA on the heart is milder than that of lidocaine, the effects of both BIDA and DIPA are even less pronounced, and they are less likely to cause cardiac side effects when similar doses are administered during nuclear medicine procedures.
D000818:Animals; D001652:Bile Ducts / Q000000981:diagnostic imaging*; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D006329:Heart Conduction System / Q000187:drug effects*; D007098:Imino Acids / Q000494:pharmacology; D007275:Injections, Intravenous; D008012:Lidocaine / Q000494:pharmacology; D008099:Liver / Q000000981:diagnostic imaging*; D009200:Myocardial Contraction / Q000187:drug effects; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D013329:Structure-Activity Relationship; D013667:Technetium / Q000494:pharmacology; D019785:Technetium Tc 99m Disofenin; D019780:Technetium Tc 99m Lidofenin
D007098:Imino Acids; D015609:Organotechnetium Compounds; C024340:technetium Tc 99m (para-butyl)iminodiacetic acid; D019780:Technetium Tc 99m Lidofenin; D013667:Technetium; D008012:Lidocaine; D019785:Technetium Tc 99m Disofenin