Differential effects of ageing on distinct features of apomorphine stereotypy in the adult rat.
Locomotor features of stereotypy induced by 0.15 mg/kg of subcutaneous apomorphine increased over the age ranges of 2.5-8 and 8-10 months in the adult rat. Perioral features of stereotypy induced by 1 mg/kg of apomorphine, and spontaneous activity did not show age-dependent changes. Heterogeneous features of apomorphine stereotypy may have distinct physiological substrates that are differentially sensitive to parameters of maturation and ageing.
D000375:Aging; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D006801:Humans; D008297:Male; D051381:Rats / Q000502:physiology*; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000502:physiology*
D001058:Apomorphine