title: Quantitative structure-activity studies on hallucinogenic mescaline analogs using modified first order valence connectivity.
abstract: Attempt is made to correlate the hallucinogenic activity of a series of mescaline analogs with Kier's molecular connectivity index (chi). In order to find a simpler and more meaningful correlation, a little modification is suggested to the first-order valence connectivity index (1 chi upsilon). The modification is found to reveal utterly simple but significant correlations between activity and 1 chi upsilon, which could describe the structural influence on the activity more vividly.
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006213:Hallucinogens; D008635:Mescaline / Q000031:analogs & derivatives* / Q000494:pharmacology; D010627:Phenethylamines / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D006213:Hallucinogens; D010627:Phenethylamines; D008635:Mescaline