Experimental chronic epilepsy in rats: a screening method for antiepileptic drugs.
Rats were rendered epileptic by subpial injection of an FeCl3 solution. Epileptiform discharges, recorded by chronically implanted extradural electrodes, were evident within 48 h of surgery and persisted for more than 6 months. It is demonstrated that this model is useful for studying new antiepileptic agents since a series of clinically effective drugs (diazepam, clonazepam, Na phenobarbital, primidone, carbamezepine, ethosuximide, diphenylhydantoin, Na valproate, GABOB) show an activity which is does-dependent and within a range satisfactorily related to human dosages.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002712:Chlorides; D002908:Chronic Disease; D002998:Clonazepam / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004569:Electroencephalography; D005290:Ferric Compounds / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
D000927:Anticonvulsants; D002712:Chlorides; D005290:Ferric Compounds; D002998:Clonazepam; D003975:Diazepam; C024555:ferric chloride