Effect of fusaric acid on the body temperature in spontaneously hypertensive and normotensive rats.
The effect of fusaric acid (FA) on the body temperature of age-matched spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto rats (WKY) was investigated at an ambient temperature of 4 degrees C. During a 7 h period of cold exposure the body temperature decreased by 6.5 degrees C in WKY (p less than 0.01) and by 5.4 degrees C in SR (p less than 0.05) after administration of 100 mg/kg FA, with the effects occurring faster in WKY. At 50 mg/kg the effect was lower. Naloxone completely abolished the temperature effect of FA in both rat strains. The naloxone antagonism may point to an opiate involvement in the thermoregulation after FA. A possible contribution of vasopressin and tetrahydroisoquinoline alkaloids to the maintenance of body temperature is also discussed.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D003080:Cold Temperature; D005669:Fusaric Acid / Q000494:pharmacology*; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D010848:Picolinic Acids / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D010848:Picolinic Acids; D009270:Naloxone; D005669:Fusaric Acid