The relationship between prolactin levels and clinical ratings in manic patients treated with oral and intravenous test doses of haloperidol.
Twelve manic patients were treated for 2 weeks with oral haloperidol; in 6 patients treatment commenced with intravenous haloperidol, and intravenous 'test' doses were given after 1, 3-5 and 14 days of oral medication. From 24 hours to 14 days baseline serum prolactin levels rose towards a plateau, as did the improvement in clinical ratings. After the first intravenous test doses of haloperidol, prolactin levels peaked at 1 hour; however, they fell to a low point at 24 hours, and no response to further test doses was seen for 3-5 days. The response tended to return at 14 days. The mechanisms underlying the changes in prolactin levels, and in clinical state, are discussed.
D000293:Adolescent; D000328:Adult; D000341:Affective Disorders, Psychotic / Q000097:blood*; D001714:Bipolar Disorder / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D013997:Time Factors
D011388:Prolactin; D006220:Haloperidol