Hepatic metabolism of heme in rats after exposure to benzene, gasoline and kerosene.
delta-Aminolevulinic acid (ALA) synthetase, delta-ALA dehydratase and heme oxygenase activities were studied in the liver of albino rats, 3 and 20 h after i.p. administration of benzene, gasoline, and kerosene. delta-ALA synthetase activity was increased markedly after benzene administration, while gasoline and kerosene treated groups showed decreased enzyme activity. Inhibition of delta-ALA dehydratase activity was observed in all three groups, but heme oxygenase activity was unchanged.
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000818:Animals; D001554:Benzene / Q000633:toxicity*; D005260:Female; D005742:Gasoline / Q000633:toxicity*; D006418:Heme / Q000378:metabolism*; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism; D007648:Kerosene / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D010578:Petroleum / Q000633:toxicity*; D000623:Porphobilinogen Synthase / Q000037:antagonists & inhibitors; D051381:Rats
D005742:Gasoline; D007648:Kerosene; D010578:Petroleum; D006418:Heme; D006419:Heme Oxygenase (Decyclizing); D000624:5-Aminolevulinate Synthetase; D000623:Porphobilinogen Synthase; D001554:Benzene