2-Deoxyglucose as a substrate for glutathione regeneration in human and ruminant red blood cells.
2-Deoxyglucose was found to be a substrate for the regeneration of GSH from GSSG in the red blood cells of humans, sheep, goats and cattle. The regeneration rate with 2-deoxyglucose varied from 15 to 56% of the rate with glucose. It is likely that 2-deoxyglucose is phosphorylated to 2-deoxyglucose-6-phosphate by HK and is then oxidized to 2-deoxygluconate-6-phosphate by G6PD. The latter reaction would produce the NADPH required for GSH regeneration.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002417:Cattle; D003837:Deoxy Sugars / Q000097:blood*; D003847:Deoxyglucose / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D005978:Glutathione / Q000097:blood*; D006041:Goats; D006801:Humans; D010084:Oxidation-Reduction; D012756:Sheep; D013045:Species Specificity
D001786:Blood Glucose; D003837:Deoxy Sugars; D003847:Deoxyglucose; D005978:Glutathione