title: Quantitative oxygen measurements before and after intravascular guanethidine blocks.
abstract: In 11 patients oxygen pressure was measured transcutaneously before and after treatment with regional intravascular sympathetic blocks in extremities with pain, impairment of function, and/or dystrophy. In 50 normal individuals PO2 levels were determined in the hand. All patients showed lower than normal values before treatment. Subjective complaints were registered by means of a questionnaire before and after treatment. Improvement of PO2 levels was observed after treatment in eight out of 11 patients while complaints disappeared. Three out of 11 patients showed no improvement of PO2 levels or any lessening of complaints. Control PO2 values in the contralateral limbs stayed on the same level as before treatment in all patients. From the results in this article it can be stated that TcPO2 measurements seem to be helpful in (1) evaluating the pretreatment microvascular state of the affected limb and (2) judging the efficacy of the block.
mesh_terms: D000328:Adult; D001340:Autonomic Nerve Block / Q000379:methods*; D005121:Extremities / Q000098:blood supply*; D005260:Female; D006145:Guanethidine / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000032:analysis; D010101:Oxygen Consumption / Q000187:drug effects*; D059408:Pain Management
chemical_list: D010100:Oxygen; D006145:Guanethidine