title: Detection of diastolic left ventricular function abnormalities in patients with coronary artery disease and normal systolic function.
abstract: We angiographically calculated left ventricular (LV) filling in 50 patients, all of whom had normal systolic LV function and 21 (42%) of whom had coronary systolic LV function and 21 (42%) of whom had coronary artery disease. Five volume determinations were made: at end systole (ESV), first third (DV 1/3, half (DV 1/2), and second third of diastole (DV 2/3), and at the end of diastole (EDV). To assess different modalities of filling, we calculated filling fractions in the first third (FF 1/3) as the ratio of volume filled in the first third diastole (DV 1/3-ESV) over total diastolic filling (EDV-ESV). Similar filling fractions (FF) were calculated at half (FF 1/2), second third (FF 2/3), and last third (FF 3/3) of diastole. We found significant differences between normal and coronary artery disease patients as follows: FF 1/3: 37.4 +/- 14.9 versus 23.8 +/- 11.9%, respectively (p less than 0.002); FF 1/2: 58.6 +/- 14.7 versus 45.3 +/- 15.1% (p less than 0.005); FF 2/3: 33.8 +/- 15.2 versus 39.0 +/- 10.4% (NS), and differences in the opposite direction in the FF 3/3: 28.8 +/- 15.2 versus 37.2 +/- 11.9% (p less than 0.02), respectively. We conclude that LV filling is accomplished differently in patients with coronary artery disease even if they have normal systolic function.
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D003327:Coronary Disease / Q000503:physiopathology*; D003971:Diastole; D005260:Female; D006339:Heart Rate; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D013318:Stroke Volume; D013599:Systole