title: Evidence for balancing selection at HLA.
abstract: HLA data from the A and B loci for 22 populations were compared with the neutrality expectations from Ewens' sampling theory. In 25 of 44 cases, there was significantly less homozygosity than expected. Although a number of factors can affect homozygosity in this manner, upon close examination only symmetrical balancing selection appears to be consistent with these data.
mesh_terms: D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008297:Male; D044469:Racial Groups; D012641:Selection, Genetic
chemical_list: D006680:HLA Antigens