[Influence of benzbromarone on the pharmacokinetics and pharmacodynamics of oxipurinol].
1. When giving 100 mg allopurinol and 20 mg benzbromarone in a fixed combination we found that the oxipurinol levels differed at 0 and after 4 h from those after administration of 100 mg allopurinol; the oxipurinol clearance is increased; benzbromarone increased the glomerular filtration rate as well as the urine volume. 2. The urate serum levels are decreased under additional administration of benzbromarone, the urate clearance is increased; urate levels in serum dropped slower than under monotherapy with alloprinol and increased again within the last 12 h.
D000328:Adult; D000493:Allopurinol / Q000378:metabolism; D001553:Benzbromarone / Q000494:pharmacology*; D001572:Benzofurans / Q000494:pharmacology*; D004338:Drug Combinations; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D008297:Male; D010117:Oxypurinol / Q000378:metabolism*; D011743:Pyrimidines / Q000378:metabolism*
D001572:Benzofurans; D004338:Drug Combinations; D011743:Pyrimidines; D001553:Benzbromarone; D000493:Allopurinol; D010117:Oxypurinol
Der Einfluss von Benzbromaron auf Pharmakokinetik und Pharmakodynamik von Oxipurinol.