title: [The 20-minute iodine uptake in Graves' disease. 2. Natural course during medical treatment (author's transl)].
abstract: The early (20 min) radioiodine uptake has been used to monitor the fluctuations in disease activity among 35 Graves' disease patients treated for 18 months with carbimazole and T3. A wide variety of behaviour was observed. Although as a group the uptake tended to fall progressively with time, in some it fell only to rise again and in others it fluctuated erratically. The initial fall in uptake in a substantial minority of patients was sufficient to suggest that carbimazole may exert a fundamental and beneficial influence of the immunological disturbance in Graves' disease.
mesh_terms: D002231:Carbimazole / Q000627:therapeutic use; D005260:Female; D006111:Graves Disease / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013997:Time Factors; D014284:Triiodothyronine / Q000627:therapeutic use
chemical_list: D007457:Iodine Radioisotopes; D014284:Triiodothyronine; D002231:Carbimazole
vernacular_title: Intérêt de la mesure porécoce de la captation de l'iode radioactif (20e minute) dans la maladie de Basedow. 2 : Evolution lors du traitement médical.