Determination of heptaminol in human plasma and urine by high-performance liquid chromatography.
Heptaminol was measured in plasma and urine following pre-column derivatisation with o-phthalaldehyde and reversed-phase high-performance liquid chromatography employing fluorescence detection. The limits of detection were sufficient for pharmacokinetic studies of the drug after clinically-used doses. Plasma concentrations of heptaminol reached peak levels (2.19 micrograms/ml) at 0.75 h after single oral doses (0.47 g of heptaminol) and declined with a half-life of 2.1 h (+/- 0.5 S.D.). Heptaminol was well absorbed and excreted rapidly, mainly unchanged in urine, 82% dose (+/- 10 S.D.).
D000605:Amino Alcohols / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D005453:Fluorescence; D006207:Half-Life; D006535:Heptaminol / Q000032:analysis* / Q000097:blood / Q000652:urine; D006801:Humans; D007700:Kinetics; D009764:o-Phthalaldehyde
D000605:Amino Alcohols; D006535:Heptaminol; D009764:o-Phthalaldehyde