title: Fiber DNA studies of premeiotic mouse spermatogenesis.
abstract: The technique of fiber DNA measurement was used to study the possibility that the lengthening of the DNA "S" phase previously reported for mouse premeiotic spermatogonia was due to a reduced number of initiation sites. The mean replicon size of neonatal mouse preleptotene cells was similar to sizes reported for adult mouse somatic cells. A slow rate of DNA chain growth was observed in all cells from day 1 through days 10-12 of age. It was felt that the meiotic entry in male mouse germ cells may involve a slower replication fork rate and other factors which increased the time between activation and replication of replicon families.
mesh_terms: D000818:Animals; D001345:Autoradiography; D004261:DNA Replication; D007700:Kinetics; D008297:Male; D008540:Meiosis; D051379:Mice; D012093:Replicon; D013090:Spermatocytes / Q000378:metabolism; D013091:Spermatogenesis; D013093:Spermatogonia / Q000166:cytology / Q000378:metabolism*; D013094:Spermatozoa / Q000378:metabolism*