[Raising albino rats in a normobaric hypoxic environment].
In the previous researches we found that the albino rats of Wistar stock, raised from the time of birth under hypoxia at simulated altitude, showed a displacement of the acid-base balance of blood towards the acid side and an increase in the 2,3-DPG, in Hb concentration and in the number of erythrocytes for mm3 of blood. In the same animals the body growth was slower in comparison to the control normoxic group. In order to separate the eventual effects of hypobaria from those of hypoxia "per se" we have repeated our research in normobaric hypoxic environment for 51 days as minimum period and 86 as maximum period of observation. The samples of blood were collected with heart drawing. The acid-base balance was determined by a hemogas-analyzer IL 213, the lactacidemia with the Boehringer enzyme tests. The animals showed again a displacement of the acid-base balance of blood towards the acid side. Nevertheless this phenomenon was less accentuated than in hypobaric conditions. The Weight curve of hypoxic animals superimposed to normoxic controls until 35 degree days. Thereafter the two curves turned apart within 20%.
D000531:Altitude; D000818:Animals; D001274:Atmospheric Pressure; D004780:Environment, Controlled; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains / Q000254:growth & development
Allevamento di ratti albini in ambiente ipossico normobarico.