Studies on the alpha-glucoside hydrolase inhibitor, adiposin. III. alpha Glucoside hydrolase inhibitory activity and antibacterial activity in vitro.
Adiposin-1 and -2 exhibited potent inhibitory activities against alpha-amylase, human salivary alpha-amylase and disaccharidases isolated from porcine small intestine. The effect of adiposin-1 and -2 on hydrolysis of glucoamylase was non-competitive. Adiposin showed antimicrobial activities against some Gram-positive bacteria, Gram-negative bacteria belonging to Enterobacteriaceae, Some anaerobic bacteria and some phytopathogenic fungi, and showed a synergistic effect on the antibacterial activity with some maltooligosaccharides. However, these antibacterial activities were suppressed by addition of various other saccharides.
D000606:Amino Sugars; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004187:Disaccharides / Q000096:biosynthesis*; D004347:Drug Interactions; D005658:Fungi / Q000187:drug effects; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D007700:Kinetics
D000606:Amino Sugars; D000900:Anti-Bacterial Agents; D004187:Disaccharides; C036274:adiposin; D006026:Glycoside Hydrolases