Selection of 53 PFC substances for better stability of emulsion and improved artificial blood substitutes.
In order to develop a new PFC emulsion which is better than Fluosol-DA as an artificial blood substitute, 53 different kinds of PFCs were evaluated from the aspects of toxicity, excretion rate and emulsion stability. From the results of the screening test, FMOQ was selected as the best material for a new emulsion. The half-life of FMOQ in the body of rats was calculated to be 7 days which was similar to FDC in Fluosol-DA, and its emulsion stabilized with the mixture of YPL and Pluronic F68 was stable at 4 degrees C for longer than 6 months. Rats extensively exchange-transfused with this emulsion survived well for a long period, indicating a high efficacy and low toxicity of this emulsion. In conclusion the FMOQ emulsion was selected to be a hopeful candidate for a second generation of artificial blood substitutes. This work was partially supported by NHLBI Contract NO1-HB-2927.
D000818:Animals; D001802:Blood Substitutes / Q000378:metabolism* / Q000633:toxicity; D001803:Blood Transfusion; D004355:Drug Stability; D005466:Fluorocarbons / Q000378:metabolism* / Q000633:toxicity; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
D001802:Blood Substitutes; D005466:Fluorocarbons