Calmodulin content in different brain areas of aging rats.
An age-related decrease of calmodulin content was detected in the striatum, cerebral cortex and cerebellum of 3-, 22- and 30-month-old rats. This age-related decrease of calmodulin level occurred both in the supernatant and in the pellet fraction of high speed centrifuged tissues. However, the rates of age-dependent calmodulin loss in the pellet and supernatant fraction were differentiated according to the cerebral region considered, suggesting a different brain area sensitivity to the aging process.
D000367:Age Factors; D000375:Aging; D000818:Animals; D001923:Brain Chemistry; D002135:Calcium-Binding Proteins / Q000032:analysis*; D002147:Calmodulin / Q000032:analysis*; D002531:Cerebellum / Q000032:analysis; D002540:Cerebral Cortex / Q000032:analysis; D003342:Corpus Striatum / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D002135:Calcium-Binding Proteins; D002147:Calmodulin