Compared efficacy of quinidine, GABA and N-trimethyl GABA upon a model of ventricular automaticity.
The effects of GABA, its quaternary derivative N-trimethyl GABA and quinidine have been studied in a model of ventricular automaticity induced in the isolated right ventricle of the rat. GABA shows low anti-automatic activity. N-trimethyl GABA and quinidine were, however, very effective drugs in the reduction of the automatic ventricular rate. The efficacy of the latter two drugs at 5 X 10(-5) M was not significantly different. We conclude that N-trimethyl GABA has some anti-automatic activity in this experimental model, similar to a classic antidysrhythmic drug such as quinidine, that would warrant further research.
D000818:Animals; D000889:Anti-Arrhythmia Agents; D005260:Female; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D011802:Quinidine / Q000494:pharmacology*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000889:Anti-Arrhythmia Agents; D005680:gamma-Aminobutyric Acid; C029081:trimethylaminobutyrate; D011802:Quinidine