On the interaction between digoxin and disopyramide.
Combined oral therapy with digoxin (0.375 mg/dl) and disopyramide (300 and 600 mg/dl) in nine subjects did not alter steady-state digoxin serum concentrations just before the daily single digoxin dose. Digoxin and creatinine clearances were not changed. After a bolus IV dose of 0.8 mg digoxin, volume of distribution (from 672 +/- 176 l to 407 +/- 153 l) and elimination t1/2 beta of digoxin were reduced significantly in five subjects after 600 mg oral disopyramide daily (from 40.2 +/- 11.7 hr to 22 +/- 7.3 hr). Total clearance and digoxin distribution t1/2 alpha did not change significantly. The clinical significance of this interaction is not clear.
D000328:Adult; D003404:Creatinine / Q000097:blood; D004077:Digoxin / Q000097:blood*; D004206:Disopyramide / Q000097:blood*; D004347:Drug Interactions; D006801:Humans; D007700:Kinetics; D008297:Male; D011725:Pyridines / Q000097:blood*
D011725:Pyridines; D004077:Digoxin; D003404:Creatinine; D004206:Disopyramide