title: Effect of lipids and other substances on the adsorption of dipalmitoyl phosphatidylcholine.
abstract: The effect of various lipids, proteins, and other substances on the adsorption rate of dipalmitoyl phosphatidylcholine (DPC) was investigated. Each substance was added to a sonicated suspension of DPC in saline, and the surface pressure of the adsorbed surface film was measured using a platinum plate suspended from an electrobalance. Pure DPC adsorbed very slowly, being complete only after 8 hr; its half-adsorption time was 91.8 +/- 8.3 min. Four additives markedly reduced the half-adsorption time of DPC: dipalmitoyl phosphatidylglycerol (1.1 +/- 0.2 min), and surfactant apoprotein (0.9 +/- 0.1 min). The half adsorption times of mixtures of DPC and the other additives ranged from 15.3 +/- 1.9 to 107.8 +/- 12.1 min.
mesh_terms: D000327:Adsorption; D000818:Animals; D006801:Humans; D008055:Lipids / Q000494:pharmacology*; D008075:Lipoproteins, HDL / Q000494:pharmacology; D011663:Pulmonary Surfactants / Q000502:physiology*; D012756:Sheep
chemical_list: D008055:Lipids; D008075:Lipoproteins, HDL; D011663:Pulmonary Surfactants