title: [Antidigoxin Fab-fragments in suicidal digoxin poisoning. Successful treatment of recurrent ventricular fibrillation].
abstract: A 49-year-old woman took about 12.5 mg digoxin with suicidal intent. Severe arrhythmias, including recurrent ventricular fibrillation, occurred. Sheep Fab fragments of digoxin-specific antibodies were administered i. v. at a dose of 480 mg. Serum free-digoxin concentration fell within half an hour to 0, with simultaneous rise of total digoxin from 13 micrograms/l to a maximum of 176 micrograms/l after 2 hours. At the same time there was marked improvement in the clinical condition with restoration of a stable sinus rhythm. There were no side effects to the Fab fragment administration.
mesh_terms: D000906:Antibodies / Q000276:immunology; D004077:Digoxin / Q000097:blood / Q000276:immunology / Q000506:poisoning*; D005260:Female; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use*; D008875:Middle Aged; D013406:Suicide, Attempted; D014693:Ventricular Fibrillation / Q000628:therapy*
chemical_list: D000906:Antibodies; D007140:Immunoglobulin Fab Fragments; D004077:Digoxin
vernacular_title: Antidigoxin-Fab-Fragmente bei suizidaler Digoxin-Intoxikation. Erfolgreiche Behandlung von rezidivierendem Kammerflimmern.