Heart imaging with cationic complexes of technetium.
The cationic technetium-99 complex trans-[99TC(dmpe)2Cl2]+, where dmpe is bis(1,2-dimethylphosphino)ethane or (CH3)2P-CH2-P(CH3)2, has been prepared and characterized by single-crystal, x-ray structural analysis. The technetium-99m analog, trans-(99mTc(dmpe) 2Cl2]+, has also been prepared and shown to yield excellent gamma-ray images of the heart. The purposeful design, characterization, and synthesis of this technetium-99m radiopharmaceutical represents a striking application of fundamental inorganic chemistry to a problem in applied nuclear medicine.
D000818:Animals; D002414:Cations, Monovalent; D004285:Dogs; D006321:Heart / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds; D010720:Phosphines; D011877:Radionuclide Imaging; D013329:Structure-Activity Relationship; D013667:Technetium
D002414:Cations, Monovalent; D015609:Organotechnetium Compounds; D010720:Phosphines; D013667:Technetium; C031898:technetium Tc 99m bis(1,2-dimethylphosphino)ethane