Effect of chronic hypoxia and high sucrose diet on body weights and glycolytic enzyme activities in liver, heart, and gastrocnemius of Sprague-Dawley and Wistar rats.
Pyruvate kinase and glucosephosphate isomerase activities were measured in liver, heart, and gastrocnemius of Sprague-Dawley and Wistar rats subjected to chronic hypoxia. Animals were fed Purina chow or a high sucrose diet. In terms of changes in body weight, Sprague-Dawleys acclimated better on Purina chow whereas Wistars adjusted better on the high sucrose diet. These two groups had the lowest heart weight:body weight ratios. Only heart enzyme activities were above levels of pair-fed controls in both strains with hypoxia. Diet affected enzyme activities in hypoxic animals: for rats on high sucrose diet, pyruvate kinase activity was greater in all tissues of both strains except gastrocnemius of Sprague-Dawleys; glucosephosphate isomerase was higher in liver of both strains and only gastrocnemius of Wistars.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D006019:Glycolysis / Q000187:drug effects; D000860:Hypoxia / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008297:Male; D009132:Muscles / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013395:Sucrose / Q000494:pharmacology*
D004040:Dietary Carbohydrates; D013395:Sucrose