Combination effect of azthreonam with four aminoglycosides on nosocomial gram-positive cocci and non-fermenting gram-negative bacteria.
The inhibitory combination effect of azthreonam with gentamicin, tobramycin, amikacin and netilmicin respectively against 50 non-fermenting gram-negative rods and 30 gram-positive cocci was compared using the checkerboard agar dilution technique. On average 49.5% of all non-fermenting strains were inhibited by additive, and 48.5% by synergistic azthreonam-aminoglycoside combinations, but only 4.5% of the gram-positive cocci were inhibited by synergistic combinations. No antagonism occurred. No significant differences could be found between the effects of the respective azthreonam-aminoglycoside combinations.
D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001398:Aztreonam; D001419:Bacteria / Q000187:drug effects*; D003428:Cross Infection / Q000382:microbiology*; D004357:Drug Synergism; D005285:Fermentation; D006801:Humans
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D001398:Aztreonam