Enzyme induction in cultured human hair follicle cells.
The enzyme aryl hydrocarbon hydroxylase is present in murine and human cultures of keratinocytes. While the activity of aryl hydrocarbon hydroxylase in murine cultures was found to be inducible after exposure to benz(a)anthracene, human keratinocytes originating from the hair follicle did not respond to this treatment. Hence, cultured human keratinocytes are not suitable for studying the molecular events that mediate the process of aryl hydrocarbon hydroxylase induction.
D000818:Animals; D000831:Animals, Newborn; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis*; D001345:Autoradiography; D001551:Benz(a)Anthracenes / Q000494:pharmacology*; D002478:Cells, Cultured; D004790:Enzyme Induction; D004848:Epithelium / Q000201:enzymology; D006197:Hair / Q000166:cytology / Q000201:enzymology*; D006801:Humans; D051379:Mice; D012867:Skin / Q000201:enzymology*; D013045:Species Specificity
D001551:Benz(a)Anthracenes; C030935:benz(a)anthracene; D001189:Aryl Hydrocarbon Hydroxylases