title: Dispersion of argininosuccinate-synthetase-like human genes to multiple autosomes and the X chromosome.
abstract: DNA sequences closely homologous to argininosuccinate synthetase are present at ten or more distinct locations in the human genome, including sites on chromosomes 6, 9 and X. Argininosuccinate synthetase thus represents one of the most widely dispersed multigene families described to date, the first instance of a multigene family associated with an enzyme of intermediary metabolism and, perhaps most striking, the first instance of a multigene family with members on both autosomes and sex chromosomes.
mesh_terms: D001124:Argininosuccinate Synthase / Q000235:genetics*; D001483:Base Sequence; D002877:Chromosomes, Human; D004247:DNA; D005260:Female; D005796:Genes; D006801:Humans; D008025:Ligases / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D012730:Sex Chromosomes; D014960:X Chromosome
chemical_list: D004247:DNA; D008025:Ligases; D001124:Argininosuccinate Synthase