A nonhuman primate model for evaluating the potential of antihypertensive drugs to cause orthostatic hypotension.
The potential of several classes of antihypertensive drugs to cause orthostatic hypotension in man was evaluated in a conscious cynomolgus monkey model. Supine and erect blood pressure and heart rate were continuously monitored before and after administration of chlorisondamine (a ganglionic blocking agent); phentolamine and prazosin (alpha-adrenergic blocking agents); propranolol (a beta-adrenergic blocking agent); and minoxidil (a vasodilator). Substantial validation of the model was accomplished when it was observed that these drugs evoked cardiovascular responses in the animal model which were similar to those which had been described in the clinical literature.
D000818:Animals; D000959:Antihypertensive Agents / Q000633:toxicity*; D001794:Blood Pressure / Q000187:drug effects; D002714:Chlorisondamine / Q000633:toxicity; D004195:Disease Models, Animal; D007024:Hypotension, Orthostatic / Q000139:chemically induced*; D008252:Macaca fascicularis; D008297:Male; D008914:Minoxidil / Q000633:toxicity; D010646:Phentolamine / Q000633:toxicity; D011224:Prazosin / Q000633:toxicity; D011433:Propranolol / Q000633:toxicity; D013564:Sympathetic Nervous System / Q000502:physiology
D000959:Antihypertensive Agents; D008914:Minoxidil; D011433:Propranolol; D002714:Chlorisondamine; D011224:Prazosin; D010646:Phentolamine