Corticosteroid binder IB: a model of glucocorticoid receptor diversity.
Corticosteroid binder IB is a glucocorticoid receptor present in rat liver, kidney cortex and proximal colon. It is characterized by a lower molecular weight than the traditional and widely distributed glucocorticoid receptor II. The two receptors also differ in charge, affinity towards various steroids and potency of binding to DNA, nuclei and homodeoxypolymers. The in vivo and in vitro production of binder IB is not affected by protease inhibitors, nor can IB be produced by RNase digestion or proteolytic cleavage of binder II or its precursor molecule. The presumptive physiological role of corticosteroid binder IB and the implied biological significance of receptor diversity are discussed.
D000818:Animals; D000936:Antigen-Antibody Complex; D003106:Colon / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D007106:Immune Sera; D007672:Kidney Cortex / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008970:Molecular Weight; D010446:Peptide Fragments / Q000032:analysis; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*; D012260:Ribonucleases / Q000494:pharmacology
D000936:Antigen-Antibody Complex; D007106:Immune Sera; D010446:Peptide Fragments; D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D012260:Ribonucleases