[Phalloidin counteracts the destructive effects of osmic acid and potassium permanganate on F-actin (author's transl)].
Osmium tetroxide and potassium permanganate destroy F-actin filaments in vitro, and split actin molecules into smaller peptides. It is shown by viscometry, spectrophotometry, electrophoresis and electron microscopy that the destruction of F-actin by these agents is inhibited by phalloidin. Other proteins are unprotected.
D000199:Actins / Q000032:analysis; D000818:Animals; D004586:Electrophoresis; D008854:Microscopy, Electron; D009132:Muscles; D009842:Oligopeptides / Q000494:pharmacology*; D009992:Osmium / Q000494:pharmacology*; D009993:Osmium Tetroxide / Q000494:pharmacology*; D010590:Phalloidine / Q000494:pharmacology*; D011196:Potassium Permanganate / Q000494:pharmacology*; D011487:Protein Conformation / Q000187:drug effects; D011489:Protein Denaturation / Q000187:drug effects; D011817:Rabbits; D013053:Spectrophotometry; D014783:Viscosity
D000199:Actins; D009842:Oligopeptides; D011196:Potassium Permanganate; D010590:Phalloidine; D009992:Osmium; D009993:Osmium Tetroxide
La phalloïdine protège la F-actine contre les effets destructeurs de l'acide osmique et du permanganate.