Metabolic effects on the lung, liver and brain following ingestion of imipramine and chlorpromazine by the rat.
Rats were exposed to imipramine and chlorpromazine (2.0 and 15.0 mg/kg body weight/day) by inclusion in drinking water for a period of 15 weeks. Generalised metabolic alterations were seen to occur after such treatment. The rate of weight gain of experimental animals after treatment with both agents was found to be significantly reduced and dose-related. An accumulation of total lipid was found at the lung surface without any significant increase in the levels of purified pulmonary surfactant. Drug-induced changes in DNA and phosphatidylcholine metabolism were also noted in lung, liver and brain tissue. The effects of both drugs were generally similar, although the largest quantitative changes were seen after chlorpromazine treatment.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002746:Chlorpromazine / Q000633:toxicity*; D002794:Choline / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D007099:Imipramine / Q000633:toxicity*; D008055:Lipids / Q000096:biosynthesis; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D008055:Lipids; D004247:DNA; D002794:Choline; D007099:Imipramine; D002746:Chlorpromazine