Intrahepatic cholestasis and sicca complex after thiabendazole. Report of a case and review of the literature.
Thiabendazole is a relatively safe and effective agent with a wide range of activity against nematodes infesting the gastrointestinal tract. A 55-yr-old man developed prolonged jaundice and sicca complex after a course of thiabendazole therapy. Endoscopic retrograde cholangiopancreatography demonstrated normal biliary tree and pancreatic ducts. Liver biopsy was consistent with a drug-induced intrahepatic cholestatic reaction. The patient recovered completely from his liver injury, but the sicca complex persisted 1 yr after the drug was given. The literature on thiabendazole-induced cholestasis and its association with sicca complex is reviewed.
D001706:Biopsy; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000139:chemically induced*; D013322:Strongyloidiasis / Q000188:drug therapy; D013827:Thiabendazole / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors
D013827:Thiabendazole