Whole brain methionine-enkephalin of ethanol-avoiding and ethanol-preferring c57BL mice.
These experiments systematically investigated ethanol preference in both the C57Bl/6N and C57Bl/6J mice utilizing three-choice 2-bottle preference test. In addition, these sublines were evaluated for whole brain methionine-enkephalin levels, which were significantly lower in C57Bl/6J mice (alcohol preferring) compared to C57Bl/6N mice (alcohol non-preferring). This finding supports the involvement of the peptidyl opiates in ethanol seeking behavior.
D000428:Alcohol Drinking; D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004195:Disease Models, Animal; D004744:Enkephalin, Methionine / Q000378:metabolism*; D005518:Food Preferences; D014644:Genetic Variation; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D013045:Species Specificity
D004744:Enkephalin, Methionine