A family with reduced plasminogen activator activity in blood associated with recurrent venous thrombosis.
6 members of a family with a tendency to thrombosis and defective fibrinolysis were examined. After stimulation of plasminogen activator release from the vessel wall by local venous occlusion or by submaximal physical exercise, they had a lower plasminogen activator activity in blood than a healthy control group (P less than 0.01). 5 of the examined members suffered from recurrent venous thrombosis. The defect appeared to be autosomal dominant.
D000293:Adolescent; D000328:Adult; D002648:Child; D003250:Constriction; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010960:Plasminogen Activators / Q000097:blood*; D012008:Recurrence; D013924:Thrombophlebitis / Q000150:complications* / Q000175:diagnosis / Q000235:genetics
D010960:Plasminogen Activators