title: Levels of Cis-Platinum in hyperthermic isolated perfusion.
abstract: The Cis-platinum levels in isolated extremity perfusion were measured in dogs and man. We found that prolonged presence of Cis-platinum in the tissue is attributed to its strong and rapid binding to serum and tissue proteins. Protein binding follows the concentration gradient. Subsequent re-diffusion into the blood followed by urinary excretion was also noted.
mesh_terms: D000818:Animals; D010478:Chemotherapy, Cancer, Regional Perfusion; D002945:Cisplatin / Q000032:analysis*; D004285:Dogs; D006358:Hot Temperature; D006801:Humans
chemical_list: D002945:Cisplatin