title: [Behavior of various parameters of lipid and energy metabolism. 6. Energy turnover in various lengths of time in rats fed a low- and high-fat diet].
abstract: Weanling Wistar rats were fed a high-fat diet (HFD) or a low-fat diet (LFD) over 3 and 5-6 weeks. In both comparable groups the absorption of energy was almost the same. In the HFD animals glucose-6-phosphate dehydrogenase (G-6-PDH, E.C. 1.1.1.49) showed its well-known restrictive behaviour in the liver and also in the fatty tissues. After 3 weeks on the respective diet, the body fat content of the LFD animals was lower than that of the HFD animals. After 6 weeks on the respective diet, the body fat contents were nearly the same in the animals of both groups. The energy turnover was greater after 3 weeks on the diet than after 6 weeks, the significantly highest values being found in animals fed over 3 weeks. After 5 weeks on the respective diet, all the energy turnover values were at a lower level, but this was the same in both animal groups. It may be concluded that the fatty-acid synthesis de novo indicated by the G-6-PDH activity does not depend upon the experimental time, and is determined only by the amount of dietary fat. In contrast to this, the establishment of the energy turnover during the experimental time is subject to relatively great changes which might be correlated with the regulation of total fat retention in the body.
mesh_terms: D000818:Animals; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D004041:Dietary Fats; D005954:Glucosephosphate Dehydrogenase
vernacular_title: Untersuchungen zum Verhalten einiger Kenngrössen des Lipid- und Energiestoffwechsels. 6. Mitt. Zum Energieumsatz bei unterschiedlich lange mit Niedrug- und Hochfettdiät ernährten Ratten.