Spinal anesthesia with tetracaine--effect of added vasoconstrictors.
The effect of adding 0.2 ml of 1:1000 epinephrine or 0.5 ml of 1% phenylephrine to 1.5 ml of 1% tetracaine for spinal anesthesia was assessed in 30 patients in a double-blind study. Phenylephrine but not epinephrine produced a significant prolongation of sensory loss in the T12 dermatome. Both vasoconstrictors produced a significant prolongation of the total duration of sensory and motor blockade. These findings differ from those in previous studies in which lidocaine and bupivacaine were used.
D000368:Aged; D000775:Anesthesia, Spinal / Q000379:methods*; D004311:Double-Blind Method; D004341:Drug Evaluation; D004837:Epinephrine / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D010656:Phenylephrine / Q000008:administration & dosage; D013748:Tetracaine / Q000008:administration & dosage*; D013997:Time Factors; D014662:Vasoconstrictor Agents / Q000008:administration & dosage*
D014662:Vasoconstrictor Agents; D013748:Tetracaine; D010656:Phenylephrine; D004837:Epinephrine