Tetrafungin, a new polyene macrolide antibiotic. I. Fermentation, isolation, characterization, and biological properties.
A new polyene macrolide antifungal antibiotic, named tetrafungin, was isolated from the cultured mycelium of a Streptomyces strain. Fermentation, isolation, physico-chemical and biological properties of the antibiotic are described. Its UV absorption spectrum and its physico-chemical characteristics place this antibiotic in the group 2.2.2.3 of the Berdy classification.
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents / Q000302:isolation & purification*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D018942:Macrolides; D011090:Polyenes / Q000302:isolation & purification / Q000633:toxicity; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000254:growth & development*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D018942:Macrolides; D011090:Polyenes; C039118:tetrafungin