alpha-L-fucosidase activity in endometrial, cervical and ovarian cancer.
alpha-L-fucosidase activity assayed on endometrial, cervical and ovarian tissue in benign and malignant conditions has been found to be increased in cancer tissue. Knowing that alpha-L-fucose plays a fundamental role in the process of inhibition of macrophages migration, increased activity of fucosidase in tumors can be interpreted as a possible mechanism by which cancer cells directly subvert the process of macrophages activation thus facilitating xenoplastic growth.
D000230:Adenocarcinoma / Q000201:enzymology*; D002294:Carcinoma, Squamous Cell / Q000201:enzymology*; D002584:Cervix Uteri / Q000201:enzymology; D046508:Culture Techniques; D004717:Endometrium / Q000201:enzymology; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000201:enzymology*; D010053:Ovary / Q000201:enzymology; D002583:Uterine Cervical Neoplasms / Q000201:enzymology; D014594:Uterine Neoplasms / Q000201:enzymology*; D005644:alpha-L-Fucosidase / Q000032:analysis*
D005644:alpha-L-Fucosidase