[Effects of pirenzepin on the course of acute gastric stress lesions (author's transl)].
Twenty-two severely ill patients with multiple injuries and sepsis were treated with IV pirenzepin or placebo 3 x 10 mg per day in the frame of the double-blind study. All the patients were examined three times with endoscopy during the 14-day observation period. In 100% of cases without prophylactic treatment, stress lesions were observed, 60% of these cases had bleeding. A prophylactic IV pirenzepin application had an unmistakable protective effect regarding the stress bleeding, number and degree of stress lesions.
D001570:Benzodiazepinones / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D010438:Peptic Ulcer Hemorrhage / Q000517:prevention & control; D010879:Piperazines / Q000627:therapeutic use*; D010890:Pirenzepine; D013276:Stomach Ulcer / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications*
D001570:Benzodiazepinones; D010879:Piperazines; D010890:Pirenzepine
Verlaufsbeobachtungen akuter Stressläsionen--Wirkung von Pirenzepin.