title: Halothane induced porcine malignant hyperthermia reversed by dantrolene.
abstract: Malignant hyperthermia (MH) was observed in three cases of Halothane anesthesia performed in six littermate pigs. In two pigs, MH was totally reversed by the intravenous administration of Dantrolene 2 or 3 mg/kg. In one pig, an injection of 2 mg/kg reversed the MH symptoms transiently Dantrolene had no effect on the serum lactate values elevated in the MH-positive pigs. The therapeutic use of Dantrolene appears to be indicated in the stress-susceptible pigs.
mesh_terms: D000818:Animals; D003620:Dantrolene / Q000627:therapeutic use*; D005260:Female; D007773:Lactates / Q000097:blood; D008297:Male; D008305:Malignant Hyperthermia / Q000188:drug therapy / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy*
chemical_list: D007773:Lactates; D003620:Dantrolene