Bone marrow necrosis.
Extensive bone marrow necrosis is an unusual histologic finding most commonly identified after autopsy. We describe a patient with poorly differentiated lymphocytic lymphoma who manifested pancytopenia and marrow necrosis. Bone marrow scanning with 99mTc-sulfur-minicolloid provided a noninvasive means to assess the extent of marrow damage. Our patient's condition improved clinically following cytotoxic chemotherapy demonstrating that marrow necrosis may be associated with a treatable disease.
D000328:Adult; D001855:Bone Marrow Diseases / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D009336:Necrosis; D010020:Osteonecrosis / Q000000981:diagnostic imaging; D010198:Pancytopenia / Q000150:complications; D011877:Radionuclide Imaging