title: Haemodynamics and oxygen consumption in the dog during high epidural block with special reference to the splanchnic region.
abstract: High epidural block (Th I-IV) with bupivacaine was carried out in 16 dogs. Mean arterial blood pressure decreased to 52% of control value owing to nearly equal decreases in systemic vascular resistance and cardiac output. Portal venous blood flow decreased from 25.8 +/- 8.6 to 16.7 +/- 7.2 ml/kg b.w. X min-1 following epidural block, while hepatic arterial blood flow remained unchanged at 9.1 +/- 3.1 ml/kg b.w. X min-1 owing to a reduction in hepatic arterial resistance of 51%. Hepatic oxygen uptake was maintained during the epidural block through increased oxygen extraction. However, total oxygen uptake decreased by 18% and, in spite of this, arteriovenous oxygen content difference increased by 25%, indicating circulatory depression.
mesh_terms: D000767:Anesthesia, Epidural; D000818:Animals; D001794:Blood Pressure; D002045:Bupivacaine / Q000494:pharmacology; D002302:Cardiac Output; D004285:Dogs; D005260:Female; D006339:Heart Rate; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D010100:Oxygen / Q000097:blood*; D013152:Splanchnic Circulation / Q000187:drug effects; D014655:Vascular Resistance
chemical_list: D010100:Oxygen; D002045:Bupivacaine