Effects of molsidomine on coronary artery thrombosis and myocardial ischemia in acute canine experiments.
Antithrombotic and hemodynamic properties of molsidomine (0.10 mg/kg i.v.) were evaluated in an in-vivo model of coronary artery thrombosis initiated by electrical stimulation for 6 h. Molsidomine prolonged time to vessel occlusion and prevented heart rate and end-diastolic pressure increase and contractility decrease. Infarct size was smaller after drug treatment related either to left ventricle (P less than 0.02) or to vessel area-at-risk (P less than 0.01). It is suggested that molsidomine has antithrombotic effects which might prevent acute coronary infarction.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D003327:Coronary Disease / Q000517:prevention & control*; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D008981:Molsidomine; D009025:Morpholines / Q000008:administration & dosage*; D009203:Myocardial Infarction / Q000517:prevention & control*; D010069:Oxadiazoles / Q000008:administration & dosage*; D013558:Sydnones / Q000008:administration & dosage*
D009025:Morpholines; D010069:Oxadiazoles; D013558:Sydnones; D008981:Molsidomine