Chronic phencyclidine increases methionine-enkephalin level in mouse striatum.
The chronic administration of phencyclidine-HCl (PCP-HCl), 10 mg/kg, for 6-7 days resulted in a significant increase in the striatal methionine-enkephalin level, although acute administration induced no change of methionine-enkephalin level in this area. The methionine-enkephalin levels in other areas investigated, i.e. the medulla oblongata/pons, the midbrain, the hypothalamus and the cortex, were unchanged after chronic PCP treatment. These results suggest that chronic administration of PCP alters the enkephalinergic neuronal activity in the striatum.
D000818:Animals; D003342:Corpus Striatum / Q000032:analysis*; D004361:Drug Tolerance; D004744:Enkephalin, Methionine / Q000032:analysis*; D051379:Mice; D008815:Mice, Inbred Strains; D010622:Phencyclidine / Q000494:pharmacology*; D013997:Time Factors
D004744:Enkephalin, Methionine; D010622:Phencyclidine