Studies on the involvement of prostaglandins in implantation in the rat.
Studies of prostaglandin (PG) production by uterine homogenates of rats in early pseudopregnancy and pregnancy showed that production of 6-oxo-PGF-1 alpha, PGF-2 alpha and PGE-2 peaked on Day 5 of pseudopregnancy whereas only 6-oxo-PGF-1 alpha and PGE-2 peaked on Day 5 of pregnancy, the day of implantation. 6-Oxo-PGF-1 alpha was the major product in both reproductive states. Indomethacin treatment of rats during early pregnancy caused a delay in implantation, a significant reduction in uterine weight, and a much reduced number or absence of implanted blastocysts in the uterus on Day 9. Plasma progesterone levels were also significantly lower in indomethacin-treated, pregnant rats. These findings support roles for prostaglandins in implantation, and in fetal development.
D015121:6-Ketoprostaglandin F1 alpha; D000818:Animals; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D007213:Indomethacin / Q000494:pharmacology*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011458:Prostaglandins E / Q000378:metabolism*; D011460:Prostaglandins F / Q000378:metabolism*; D011555:Pseudopregnancy; D011863:Radioimmunoassay; D051381:Rats; D014599:Uterus / Q000378:metabolism*
D011458:Prostaglandins E; D011460:Prostaglandins F; D011374:Progesterone; D015121:6-Ketoprostaglandin F1 alpha; D007213:Indomethacin