[Factors affecting the growth and extension of gastric cancer--analysis of retrospective observation].
It is our aim to clarify an importance of severe lymphoid infiltration and peptic ulcer to the growth and deep extension of the gastric carcinoma, using 38 cases of gastric carcinoma observed retrospectively from one year to nine years and six months. Four cases of gastric carcinoma with lymphoid stroma were found in this series. Its mucosal extension is markedly suppressed compared with that of carcinomas without lymphoid stroma. Thirteen cases clinically showed a distinct deep invasion into the gastric wall during the retrospective observation period of one year to nine years and six months, while 21 cases repeated peptic ulcers in the tumor tissue without a distinct deep invasion during the period of one year and one month to six years and three months. On an examination of the resected stomach, the former had a common histological characteristic, that is, no complication of peptic ulcer or, even if presents, relatively small peptic ulcers to the tumor mass in the submucosa or in the further deep layers. On the contrary, the latter always showed multiple or recurrent, relatively large ulcers to the tumor mass in the submucosa or in the further deep layers. It is concluded that the severe lymphoid infiltration and peptic ulcers in the gastric carcinoma are factors inhibiting the growth of gastric carcinomas.
D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000150:complications / Q000473:pathology*; D013274:Stomach Neoplasms / Q000150:complications / Q000473:pathology*