Menstruation-related periodic hypersomnia: a case study with successful treatment.
A 16-year-old girl suffered from 1 to 2-week periods of hypersomnia associated with each menstruation. Serum hormone levels were normal. CSF concentrations of homovanillic acid and 5-hydroxyindolacetic acid were lower in hypersomniac than in symptom-free phases. 3-methoxy-4-hydroxyphenylethylene glycol was not affected. The sleep periods occurred only in connection with ovulatory menstrual cycles. When ovulation was inhibited by a combination of ethinylestradiol and lynestrenol, an oral contraceptive pill, the hypersomnia ceased. Thus, the hypersomnia seemed to be linked to the occurrence of ovulatory menstruations.
D000293:Adolescent; D003277:Contraceptives, Oral, Combined / Q000627:therapeutic use; D006970:Disorders of Excessive Somnolence / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008234:Lynestrenol / Q000627:therapeutic use; D008598:Menstruation; D008656:Mestranol / Q000627:therapeutic use; D010060:Ovulation; D012893:Sleep Wake Disorders / Q000503:physiopathology*
D003277:Contraceptives, Oral, Combined; D004338:Drug Combinations; C002746:Noracycline; D008656:Mestranol; D008234:Lynestrenol