[Studies on the mechanism and the significance of prostaglandin biosynthesis by the ovary --ovulation block by the indomethacin and incubation of the follicle (author's transl)].
The involvement of prostaglandins (PGs) in the process of ovulation was studied. 1) The superovulation of immature rat was blocked by indomethacin dose dependently and which was reversed by the administration of PGs. 2) Preovulatory increase of PGs was observed in the ovaries of rats and follicular fluid of gilts. 3) Immature rat follicle synthesised PGE, PGF, and 6ketoPGF1 alpha in organ culture. This synthesis was activated by hCG and suppressed by actinomycin D and puromycin. 4) Production of PGs by gilt and human follicles was observed and which was activated by hCG.
D015121:6-Ketoprostaglandin F1 alpha; D000328:Adult; D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D008875:Middle Aged; D006080:Ovarian Follicle / Q000378:metabolism; D010053:Ovary / Q000378:metabolism*; D010060:Ovulation / Q000187:drug effects*; D011458:Prostaglandins E / Q000096:biosynthesis*; D011460:Prostaglandins F / Q000096:biosynthesis*; D051381:Rats; D013552:Swine
D006063:Chorionic Gonadotropin; D011458:Prostaglandins E; D011460:Prostaglandins F; D015121:6-Ketoprostaglandin F1 alpha; D007213:Indomethacin