title: Epiphysial growth after free fibular transfer with and without microvascular anastomosis. Experimental study in the dog.
abstract: The proximal fibular epiphysis was transferred in young puppies using microvascular techniques. The study demonstrated, as have previous investigators, that free epiphysial transfer without vascular anastomosis results in death of the chondrocytes of the growth plate. Histologically, the chondrocytes do not take up labelled proline, indicating diminished metabolic activity; do not take up radioactive thymidine, indicating that they are not dividing; and there is eventual disruption of the normal histological picture. In contrast, where the microvascular anastomoses re-established the blood supply to the growth plate, the epiphyses demonstrated normal histological appearance, uptake of radioactive proline and thymidine and continued to grow but at a slightly diminished rate. It is concluded that continued growth can occur after free vascularised epiphysial transfer in the dog.
mesh_terms: D000818:Animals; D004285:Dogs; D004838:Epiphyses / Q000098:blood supply / Q000166:cytology / Q000254:growth & development*; D005360:Fibula / Q000098:blood supply / Q000166:cytology / Q000254:growth & development / Q000637:transplantation*; D008722:Methods; D008866:Microsurgery; D014656:Vascular Surgical Procedures