Inhibition of nitroblue tetrazolium reduction by metallothionein.
Metallothionein inhibited in a concentration-dependent fashion the reduction of nitroblue tetrazolium [NBT] mediated by xanthine oxidase and by NADH-phenazine methosulfate. This catalytic activity of metallothionein for dismutation of O2- is dependent on the copper content in metallothionein.
D000818:Animals; D002374:Catalase / Q000378:metabolism; D003300:Copper / Q000494:pharmacology; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008668:Metallothionein / Q000378:metabolism*; D009580:Nitroblue Tetrazolium; D010084:Oxidation-Reduction; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism; D013778:Tetrazolium Salts; D014969:Xanthine Oxidase / Q000378:metabolism
D013778:Tetrazolium Salts; D009580:Nitroblue Tetrazolium; D003300:Copper; D008668:Metallothionein; D002374:Catalase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase