Venous complications of two diazepam preparations related to size of vein.
The venous complications associated with the administration of two preparations of diazepam, an aqueous (Valium) or a lipid (Diazemuls) preparation were investigated in 100 patients before upper gastrointestinal endoscopy in a double-blind randomized study. No differences in pain during injection or subsequent thrombophlebitis were found when a large vein was used for the injections. In a retrospective study of 78 patients who had received either preparation in a vein on the dorsum of the hand, the frequency of thrombophlebitis was significantly less with the lipid preparation. Both preparations provided effective sedation for endoscopy.
D001132:Arm / Q000098:blood supply; D003975:Diazepam / Q000008:administration & dosage / Q000009:adverse effects*; D004724:Endoscopy; D006225:Hand / Q000098:blood supply; D006801:Humans; D010146:Pain / Q000139:chemically induced*; D013924:Thrombophlebitis / Q000139:chemically induced*; D014680:Veins / Q000033:anatomy & histology*
D003975:Diazepam