title: [Anti-müllerian hormone and lectins. New perspectives (author's transl)].
abstract: Anti-müllerian hormone (AMH), responsible for the regression of müllerian ducts in male fetuses in a glycoprotein. Its affinity towards 7 different lectins has been tested in a density gradient sedimentation system. AMH binds with low affinity to the E subunit of the Phaseolus vulgaris lectin. On the opposite, high affinity binding was observed with wheat germ agglutinin (WGA) and confirmed by affinity chromatography on immobilized WGA. Anti-müllerian activity was totally bound by the column and eluted by N-acetyl-glucosamine. These data confirm the glycoprotein nature of AMH and offer great promise for its purification.
mesh_terms: D054304:Anti-Mullerian Hormone; D002499:Centrifugation, Density Gradient; D002846:Chromatography, Affinity; D005260:Female; D006023:Glycoproteins; D006131:Growth Inhibitors; D006801:Humans; D037102:Lectins / Q000378:metabolism*; D008297:Male; D009095:Mullerian Ducts / Q000502:physiology*; D011247:Pregnancy; D013735:Testicular Hormones / Q000302:isolation & purification* / Q000378:metabolism
chemical_list: D006023:Glycoproteins; D006131:Growth Inhibitors; D037102:Lectins; D013735:Testicular Hormones; D054304:Anti-Mullerian Hormone
vernacular_title: Hormone anti-müllérienne et lectines. Nouvelles perspectives.