Pulmonary thromboembolism during therapy of dirofilariasis with thiacetarsamide: modification with aspirin or prednisolone.
The effects that 4 weeks of treatment of dirofilaria-infected dogs with either aspirin or prednisolone had on the pulmonary thromboembolism which occurs after they are given thiacetarsamide were determined, using light and electron microscopies. Pulmonary lesions in control dogs at 4 weeks after thiacetarsamide was given were compared with lesions in dogs which were treated with either aspirin (22 mg/kg daily) or prednisolone (1 mg/kg daily) during the 4-week period after adulticide was given. Pulmonary vascular and perivascular lesions were most severe in the prednisolone-treated dogs and least severe in the aspirin-treated dogs. The aspirin-treated dogs had greater resolution of pulmonary arterial proliferative disease, and prednisolone-treated dogs had the lesser resolution.
D000818:Animals; D001148:Arsenamide / Q000009:adverse effects* / Q000627:therapeutic use; D001152:Arsenicals / Q000009:adverse effects*; D001241:Aspirin / Q000627:therapeutic use*; D004184:Dirofilariasis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004347:Drug Interactions; D008168:Lung / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D011239:Prednisolone / Q000627:therapeutic use*; D011651:Pulmonary Artery / Q000648:ultrastructure; D011655:Pulmonary Embolism / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
D001152:Arsenicals; D011239:Prednisolone; D001241:Aspirin; D001148:Arsenamide