The origin of plasma proteins in human amniotic fluid: the significance of alpha 1-antichymotrypsin complexes.
12 proteins were studied in serum and amniotic fluid from 20 women in late pregnancy by two-dimensional immunoelectrophoresis. A close inverse relationship was observed between the amniotic fluid/serum concentration ratios of 11 proteins and their Stokes radii. These proteins enter the liquor from the maternal blood by molecular filtration. The concentration of alpha 1-antichymotrypsin in amniotic fluid was often higher than expected and the protein was often partially complexed. alpha 1-Antichymotrypsin is probably not actively secreted into amniotic fluid but may be selectively retained after complexing.
D000653:Amniotic Fluid / Q000032:analysis*; D001798:Blood Proteins / Q000096:biosynthesis*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002850:Chromatography, Gel; D002918:Chymotrypsin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005260:Female; D006801:Humans; D011247:Pregnancy; D014361:Trypsin Inhibitors / Q000378:metabolism*; D000514:alpha 1-Antichymotrypsin
D001798:Blood Proteins; D014361:Trypsin Inhibitors; D000514:alpha 1-Antichymotrypsin; D002918:Chymotrypsin