[Relationship between the mechanism of erythrocyte sensitization by proteins and the spatial interrelationship between immunoglobulins and their fragments and the surface of formalin treated erythrocytes].
The methods of serological analysis have been used to study the immunochemical (antibody and antigenic) properties and hemosensitizing activity of a number of immunoglobulin sensitins: immune serum, its fractions (globulin, 7S, 19s, gamma-globulin), as well as pure antibodies and their F(ab)2-and Fab-fragments. According to the findings obtained in this study, the hemosensitizing activity of sensitins may be classified as immunoglobulin activity and antigenic activity. All sensitins have been found to have both immunoglobulin and antigenic activity, with the exception of Fab-fragments having only antigenic activity. The results of this study and their comparison with the known data on the fine structure and properties of IgG form the basis for drawing up the picture of the possible location of IgG and their fragments on the surface of a tanned erythrocyte.
D000327:Adsorption; D000818:Animals; D000906:Antibodies / Q000276:immunology; D000941:Antigens / Q000276:immunology*; D004910:Erythrocyte Membrane / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology*; D006386:Hemagglutination Tests; D006736:Horses / Q000276:immunology; D007106:Immune Sera / Q000276:immunology; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D011233:Precipitin Tests; D012756:Sheep
D000906:Antibodies; D000941:Antigens; D007106:Immune Sera; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D007075:Immunoglobulin M
O mekhanizme sensibilizatsii éritrotsitov belkami v sviazi s prostranstvennymi vzaimootnosheniiami immunoglobulinov i ikh fragmentov s poverkhnost'iu tanizirovannykh éritrotsitov.