title: Effect of chronic administration of inhibin and testosterone on spermatogenesis in adult male rats.
abstract: Inhibin (Inh) and testosterone (T) were administered to adult male rats for 32 days to evaluate their effect on spermatogenesis. Fifty micrograms of Inh was injected subcutaneously twice daily, and T was administered as Silastic implants 2.5 cm in length. Weights of testes and epididymides were significantly decreased in (Inh + T)- and T-treated groups, but not in Inh-treated rats. Although Inh alone could suppress both the testicular and the epididymal sperm count, maximum suppression was observed in the (Inh + T)-treated group. The effect on the epididymal sperm count, however, was pronounced. The accessory organ weights remained unaffected in all treated groups. Chronic administration of Inh and T results in partial impairment of spermatogenesis.
mesh_terms: D000818:Animals; D003864:Depression, Chemical; D004822:Epididymis / Q000033:anatomy & histology; D007265:Inhibins / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012756:Sheep; D013076:Sperm Count; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000033:anatomy & histology; D013739:Testosterone / Q000008:administration & dosage* / Q000494:pharmacology; D013997:Time Factors
chemical_list: D013739:Testosterone; D007265:Inhibins