Tuftsin and D-Arg3-tuftsin possess analgesic action.
Tuftsin has marked analgesic activity but is less potent than D-Arg3-tuftsin. The absence of an antagonistic effect of naloxone on tuftsin and its analogue suggests that these substances do not act on opiate receptors. Tuftsin and its analogues may represent a new class of substances of interest in the search for new analgesics.
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D007128:Immunoglobulin Fragments / Q000494:pharmacology*; D007276:Injections, Intraventricular; D007700:Kinetics; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D014405:Tuftsin / Q000031:analogs & derivatives / Q000494:pharmacology*
D000700:Analgesics; D007128:Immunoglobulin Fragments; D009270:Naloxone; C029231:tuftsin, Arg(3)-; D009020:Morphine; D014405:Tuftsin