title: Effect of androgen on the transcription of rat prostatic binding protein genes.
abstract: The mechanisms whereby androgens modulate mRNA levels for the C1, C2 and C3 prostatic binding protein genes in the rat ventral prostate have been investigated. Transcription rates for the 3 genes were lowered 2-3-fold upon castration but found to increase again upon re-administration of testosterone. Although this demonstrated a direct effect of androgens at the transcriptional level for these genes, the rates of mRNA synthesis were insufficient to account for previously observed steady-state measurements. This was confirmed by analysis of the nuclear steady-state levels for each mRNA following hormonal manipulation of the rats in vivo. It is concluded that besides direct transcriptional regulation, androgens must also exert a major effect of the half-life of these mRNAs in the rat ventral prostate.
mesh_terms: D000727:Androgen-Binding Protein / Q000235:genetics*; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D005796:Genes / Q000187:drug effects*; D008297:Male; D009693:Nucleic Acid Hybridization; D060789:Prostatein; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D060765:Secretoglobins; D013739:Testosterone / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects*; D014598:Uteroglobin; D060788:Mammaglobin B
chemical_list: D000727:Androgen-Binding Protein; D002352:Carrier Proteins; D060789:Prostatein; D012333:RNA, Messenger; D060765:Secretoglobins; D013739:Testosterone; D014598:Uteroglobin; C511484:Scgb1d2 protein, rat; C511483:Scgb1d4 protein, rat; C556468:Scgb2a1 protein, rat; D060788:Mammaglobin B