Spinal interneurone depression by DS103-282.
The depressant effect of 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiodiazole (DS103-282) on the polysynaptic excitation of interneurones in the cat spinal cord appears to be related to a postsynaptic reduction in the effectiveness of excitatory transmitters than to interference with their presynaptic release.
D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D002415:Cats; D003000:Clonidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003864:Depression, Chemical; D004558:Electric Stimulation; D007395:Interneurons / Q000187:drug effects*; D013116:Spinal Cord / Q000187:drug effects*
D000596:Amino Acids; C023754:tizanidine; D003000:Clonidine