title: [Treatment of Amanita phalloides poisoning with silybin in combination with penicillin and cortisone].
abstract: A report is presented of Amanita phalloides poisoning in a family of 3 members admitted with acute gastrointestinal symptoms after eating a meal of various self-picked mushrooms. A latent period of 11 hours preceded the onset of symptoms, a typical feature of this form of poisoning. There was an enormous increase in liver-specific enzymes in two of the cases. The clinical picture was markedly mitigated by the early initiation of silybin therapy, in combination with penicillin and cortisone. The patients made a rapid symptomatic recovery and the liver parameters were sufficiently improved by the 12th day so that the patients could be discharged.
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000545:Amanita; D001219:Aspartate Aminotransferases / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D005419:Flavonoids / Q000627:therapeutic use*; D006801:Humans; D008099:Liver / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009145:Mushroom Poisoning / Q000188:drug therapy* / Q000201:enzymology; D010400:Penicillin G / Q000627:therapeutic use*; D011239:Prednisolone / Q000627:therapeutic use*; D012838:Silymarin / Q000627:therapeutic use*
chemical_list: D005419:Flavonoids; D012838:Silymarin; D011239:Prednisolone; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D010400:Penicillin G
vernacular_title: Therapie der Knollenblätterpilzvergiftung mit Silibinin in Kombination mit Penicillin und Cortison.