[Metabolic aspects of parsalmide in the cat (author's transl)].
2-Proparglyoxy-5-amino-N-(n-butyl)-benzamide(parsalmide, My 41-6) given s.c. to the cat and excreted in the urine, was present partly as unchanged parsalmide (25-62% of total excreted compounds), partly as unstably conjugated compounds (17-36%, mainly N-glucuronilparsalmide), and partly as stably conjugated compounds (11-36%, mainly N-acetylparsalmide). Urinary excretion of parsalmide and its metabolites continued for some days, indicating a slow excretion from the body, contrasting with other species, man included, previously examined. Summarizing, there are some 5-6 metabolites of parsalmide in the urine of treated cats, apart from unchanged parsalmide.
D000818:Animals; D001192:Arylsulfatases / Q000652:urine; D001549:Benzamides / Q000378:metabolism* / Q000652:urine; D002415:Cats; D005965:Glucuronates / Q000652:urine; D005966:Glucuronidase / Q000652:urine; D013045:Species Specificity
D001549:Benzamides; D005965:Glucuronates; D001192:Arylsulfatases; D005966:Glucuronidase; C100267:parsalmide
Untersuchungen uber den Stoffwechsel von Parsalmid bei der Katze.