Effects of alpha-adrenergic blocking agents on stereotyped behavior induced by apomorphine in rats.
1. The effects of alpha-adrenergic blocking agents on stereotyped behavior induced by apomorphine in rats were studied. 2. Pretreatment of rats with 5 and 10 mg/kg of phenoxybenzamine or phentolamine displaced the dose-response curves for apomorphine-induced stereotypy to the left in a dose dependent manner. The ED50 for apomorphine was reduced from 1.92 +/- 0.38 (mean +/- SEM) to 0.63 +/- 0.08 by 10 mg/kg phenoxybenzamine and from 1.92 +/- 0.38 to 0.61 +/- 0.10 by 10 mg/kg phentolamine. 3. These results support the view that the expression of dopaminergic-induced stereotyped behavior is dependent on noradrenergic activity in the central nervous system.
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D008297:Male; D010643:Phenoxybenzamine / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*
D010643:Phenoxybenzamine; D001058:Apomorphine; D010646:Phentolamine