title: Lesions of the superior colliculus in the rat differentiate between nigrostriatal and mesolimbic dopamine systems.
abstract: Bilateral electrolytic lesions of the superior colliculus in rats increased spontaneous locomotor activity, enhanced amphetamine-induced hyperactivity and attenuated apomorphine-induced biting. These lesions were associated with an increased rate of turnover of dopamine in the nucleus accumbens, but not in the striatum. Similarly concentrations of the dopamine metabolites homovanillic acid and 3,4-dihydroxyphenylacetic acid were elevated in accumbens tissue but not in striatum in rats with bilateral collicular lesions. The results indicate that lesions of the superior colliculus cause differentiation between hyperactivity and stereotypy, and that this may be related to blockade of a nigrostriatal outflow, and relief of inhibition on mesolimbic systems.
mesh_terms: D000818:Animals; D001931:Brain Mapping; D003342:Corpus Striatum / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D006801:Humans; D008032:Limbic System / Q000502:physiology*; D008297:Male; D008636:Mesencephalon / Q000502:physiology*; D009043:Motor Activity / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D051381:Rats; D013239:Stereotyped Behavior / Q000502:physiology; D013378:Substantia Nigra / Q000502:physiology*; D013477:Superior Colliculi / Q000502:physiology*
chemical_list: D004298:Dopamine