Effect of KC-9432, a new hypolipidemic compound, on high density lipoprotein cholesterol in rats.
KC-9432 (a new hypolipidemic compound, alpha-[p-(p-chlorobenzoyl) phenoxy-alpha-cyclohexyl acetic acid ethyl ester) was studied in rats for its effect on plasma lipid and lipoprotein levels. KC-9432 was particularly effective in hyperlipidemia in rats fed with a diet containing 2% cholesterol and 1% sodium cholate. The hypocholesterolemic activity of KC-9432 was far more potent than that of clofibrate. KC-9432 markedly increased the reduced HDL cholesterol level in dietary-induced hyperlipidemia in rats.
D000818:Animals; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL; D002793:Cholic Acids / Q000097:blood; D002994:Clofibrate / Q000494:pharmacology; D006949:Hyperlipidemias / Q000097:blood / Q000139:chemically induced; D000960:Hypolipidemic Agents; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D010647:Phenyl Ethers / Q000494:pharmacology*; D051381:Rats
D008076:Cholesterol, HDL; D002793:Cholic Acids; D000960:Hypolipidemic Agents; D008055:Lipids; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D010647:Phenyl Ethers; C026969:KC 9432; D002784:Cholesterol; D002994:Clofibrate