Subchronic toxicity study in rats fed gum karaya.
Gum karaya was given to groups of 15 rats of each sex at levels of 0 (control), 0.2, 1 or 5% (w/w) in the diet for 13 wk. An increase in faecal bulk was seen in all treated groups throughout the study. There was a decrease in weight-gain at the highest dietary level (significant only in the females), which was associated with a marginal reduction in food-conversion efficiency. Males given 1 or 5% drank more than the controls and a transient increase in water intake was seen in females given the highest level. The no-untoward-effect level from this study was 5% (w/w) of the diet, providing a mean intake of about 4 g karaya gum/kg body weight/day.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004327:Drinking Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D007618:Karaya Gum / Q000633:toxicity*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011134:Polysaccharides / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D011134:Polysaccharides; D007618:Karaya Gum