Growth and antigenic properties of a spontaneously regressing subline of leukemia L1210.
A subline (1210/MR) of the lethal parental L1210 leukemia cell line has been demonstrated to undergo dose-dependent spontaneous regression in both syngeneic and hybrid mice, although the regressing and non-regressing cells differed only slightly in growth rate. The regressed mice, like those actively immunized, were specifically protected from the subsequent challenge with L1210 cells. In addition, L1210/MR cells when coinjected could protect CD2F1 mice from low but lethal doses of L1210 cells. These two cell lines shared at least one cross-reacting cell surface antigen as determined by an isologous anti-L1210/MR immune serum. Such immune serum after being absorbed by L1210 cells still retained its in vitro complement-dependent cytotoxicity against L1210/MR cells. We conclude that the cell lines are antigenically related but L1210/MR cells may possess additional novel antigens, and that spontaneous regression of L1210 may be an L1210-specific immunological phenomenon.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D005260:Female; D007939:Leukemia L1210 / Q000276:immunology / Q000401:mortality / Q000473:pathology*; D051379:Mice; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA; D009365:Neoplasm Regression, Spontaneous; D009368:Neoplasm Transplantation
D000951:Antigens, Neoplasm; D000954:Antigens, Surface