The effect of enzyme therapy on plasma lipid levels in the elderly.
(1) An enzyme preparation, Vasolastine, administered intramuscularly, to a group of elderly subjects (mean age 81.7) reduced fasting plasma cholesterol and triglyceride levels by amounts which were proportional to their initial concentration. (2) Triglyceride levels 3 h after a fat-rich meal were also directly dependent on the initial fasting level. This relationship is lowered significantly after 25 days of Vasolastine treatment. (3) It is suggested that these observations, taken in conjunction with the results of in vitro studies, confirm that Vasolastine acts synergistically with endogenous lipoprotein lipase.
D000368:Aged; D000375:Aging / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D004041:Dietary Fats / Q000494:pharmacology; D057487:Enzyme Therapy; D005215:Fasting; D005260:Female; D006801:Humans; D008049:Lipase; D008055:Lipids / Q000097:blood*; D008071:Lipoprotein Lipase / Q000097:blood; D008084:Lipoxygenase; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D004041:Dietary Fats; D008055:Lipids; D014280:Triglycerides; C029007:vasoelastine; D002784:Cholesterol; D008084:Lipoxygenase; D008049:Lipase; D008071:Lipoprotein Lipase