[Action of heparin on pulmonary lipids and alveolar surfactant in rabbits].
The effect of subcutaneous 1000 IU/kg calcic heparin every 12 hr for 7 days on lung lipids and pulmonary surfactant was examined in 10 male rabbits weighing 2.5-3.5 kg. Comparison with an identical control group showed a decrease in phospholipids and lecithins in the lung homogenate extract and in the alveolar liquid bubble stability index. The difference in the means was highly significant (P less than 0.001) for all three parameters.
D000818:Animals; D006493:Heparin / Q000494:pharmacology*; D050356:Lipid Metabolism; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D011650:Pulmonary Alveoli / Q000187:drug effects; D011663:Pulmonary Surfactants / Q000096:biosynthesis*; D011817:Rabbits
D010713:Phosphatidylcholines; D010743:Phospholipids; D011663:Pulmonary Surfactants; D006493:Heparin
Azione dell'eparina sui lipidi polmonari e sul surfactant alveolare di conigli.