Protein C, an antithrombotic protein, is reduced in hospitalized patients with intravascular coagulation.
Activated protein C is a potent anticoagulant and profibrinolytic enzyme that can be derived from the vitamin-K-dependent serine protease zymogen, protein C, by the action of thrombin. Protein C antigen concentration was determined in plasmas from normals (n = 40) and from 38 patients with intravascular coagulation as evidenced by positive FDP (greater than micrograms/ml). Plasma protein C was 4 micrograms/ml in normals and was significantly depressed (less than 2 SD below the mean of normals) in 19 of the 38 patients. Of 15 patients with suspected intravascular coagulation but normal FDP, protein C was decreased in 5 individuals; 3 of these 5 patients had liver disease. Based on these results, we suggest that extensive activation of the coagulation system in vivo causes a significant consumption of protein C, presumably due to its activation by thrombin and subsequent clearance.
D000941:Antigens / Q000032:analysis; D001777:Blood Coagulation; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000150:complications; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006023:Glycoproteins / Q000032:analysis / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000150:complications; D011486:Protein C
D000941:Antigens; D005338:Fibrin Fibrinogen Degradation Products; D006023:Glycoproteins; D011486:Protein C