The C4 beta-chain: evidence for a genetically determined polymorphism.
Using sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) five different beta-chain patterns of denaturated human C4 were observed: C4 beta H, beta H greater than L, beta H = L, beta H less than L, and beta L. In 32 families with 174 offspring the segregation of C4 beta-chain types followed that of the other major histocompatibility complex (MHC) markers. It is concluded that the C4 beta-chain patterns represent a genetically determined polymorphism, coded within the known C4A and B gene region.
D003181:Complement C4 / Q000032:analysis / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics; D008297:Male; D010375:Pedigree; D010455:Peptides / Q000032:analysis / Q000235:genetics; D010641:Phenotype; D011110:Polymorphism, Genetic
D003181:Complement C4; D007126:Immunoglobulin Allotypes; D010455:Peptides