Aflatoxin-macromolecular adducts in the hepatic and nonhepatic tissues of F-344 male rats.
In order to understand the resistance of nonhepatic organs to aflatoxin-induced aberrations, subcellular contents of 3-HAF and its covalent binding in liver, kidney and testes were determined. The amount of incorporated radioactivity into nonhepatic fractions was significantly lower. Protein deficiency also caused a decrease in the 3-HAF content in the liver, but showed no change in other two organs.
D000348:Aflatoxins / Q000378:metabolism*; D000818:Animals; D004032:Diet; D004044:Dietary Proteins / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D046911:Macromolecular Substances; D008297:Male; D009369:Neoplasms / Q000139:chemically induced; D051381:Rats; D011916:Rats, Inbred F344; D013737:Testis / Q000378:metabolism
D000348:Aflatoxins; D004044:Dietary Proteins; D046911:Macromolecular Substances