Anti-M causing delayed hemolytic transfusion reaction.
A 52-year-old gravida 1, para 1 woman with M- red cells experienced a delayed hemolytic transfusion reaction and exhibited an anti-M antibody following the infusion of four units of M+ red cells. Measurements of erythrocyte survival using 51Cr-labeled donor M+ and M- red cells and in vitro studies of monocyte-macrophage phagocytosis of sensitized reagent red cells implicate anti-M in the pathogenesis of hemolysis.
D002860:Chromium Radioisotopes; D003298:Coombs Test; D004912:Erythrocytes; D005260:Female; D006461:Hemolysis; D006801:Humans; D008951:MNSs Blood-Group System; D008875:Middle Aged; D065227:Transfusion Reaction
D002860:Chromium Radioisotopes; D008951:MNSs Blood-Group System