A new aminoglycoside antibiotic, sannamycin C and its 4-N-glycyl derivative.
Streptomyces sannanensis KC-7038 used for the production of sannamycins A and B has also produced another antibiotic sannamycin C, in the culture broth. Physico-chemical characterization revealed that sannamycin C is a new aminoglycoside antibiotic having 6-N-methylpurpurosamine C and 2-deoxy-3-epi-fortamine. Its 4-N-glycyl derivative indicated inhibitory activity against Gram-positive and Gram-negative bacteria containing aminoglycoside resistant strains.
D000617:Aminoglycosides / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004352:Drug Resistance, Microbial; D005285:Fermentation; D008968:Molecular Conformation; D013302:Streptomyces / Q000378:metabolism*; D013329:Structure-Activity Relationship
C030876:4-N-glycyl sannamycin C; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C030875:sannamycin C