[Effect of glutamine on synaptosome respiration of the rat brain in depolarization and sleep disturbance].
Depolarization induced by the increase in potassium content in the medium results in the augmented oxygen consumption by the rat brain synaptosomes, when glucose and pyruvate were used as substrates; with glutamate as substrates no such effect of potassium occurred. No effect of depolarization is present in the case of synaptosomes from animals with a paradoxical sleep deprivation; the addition of glutamine (0.5 mM) restores the capability in synaptosomes of metabolic response to depolarization. No effect of glutamine is observed with synaptosomes from brain hemispheres of rats with disturbed sleep.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D005973:Glutamine / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D010101:Oxygen Consumption / Q000187:drug effects*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012893:Sleep Wake Disorders / Q000378:metabolism*; D013574:Synaptosomes / Q000187:drug effects*
D005973:Glutamine; D011188:Potassium
Vliianie glutamina na dykhanie sinaptosom golovnogo mozga krys v usloviiakh depoliarizatsii i narusheniia sna.