title: Hematoma-induced febrile response in the pediatric patient.
abstract: Frequently there is a temperature elevation in children following operative procedures or trauma involving the long bones. A combined clinical and laboratory study investigated the possibility that this was secondary to blood resorption. A clinical study was conducted by reviewing the records of all children admitted to the hospital over a 10-year period with closed femoral or tibial fractures. All these patients demonstrated a temperature elevation to at least 101 degrees F. In the laboratory study, rabbits of different ages were bled, and this blood was reinjected into their quadriceps muscle to create hematomas. Control rabbits were hemorrhaged and either were not reinjected with their blood or were injected intramuscularly with lactated Ringer's solution. Those rabbits that received the intramuscular blood injections developed significant temperature elevations, and the younger the rabbit the more pronounced the temperature rise.
mesh_terms: D000293:Adolescent; D000818:Animals; D002648:Child; D002675:Child, Preschool; D005264:Femoral Fractures / Q000097:blood / Q000150:complications*; D005334:Fever / Q000209:etiology*; D006400:Hematocrit; D006406:Hematoma / Q000097:blood / Q000150:complications*; D006614:Hindlimb; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011817:Rabbits; D013978:Tibial Fractures / Q000097:blood / Q000150:complications*