title: Induction of high voluntary ethanol intake in dependent rats.
abstract: The experimental conditions under which oral high intake may be induced in previously intoxicated rats have been investigated. Seventeen rats were administered intragastrically with 10 g/kg/day of ethanol for 15 days. At cessation of treatment, they were presented a single bottle of alcoholic solution (10% v/v) during 24 hr. For the following 6 days, they received either an ethyl alcohol solution or water in alternation for 8 hours each. Ethanol treated rats exhibited a high oral intake of ethanol equivalent to the previously injected doses. Controls displayed a significantly lower intake of ethanol. It is concluded that the suppression of the withdrawal state by an initial priming oral intake of ethanol in physically dependent rats is a condition for the development of a conditioned taste preference for ethanol as a basis for the behavioral dependence.
mesh_terms: D000428:Alcohol Drinking; D000437:Alcoholism / Q000523:psychology*; D000818:Animals; D004195:Disease Models, Animal; D000431:Ethanol; D006801:Humans; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000431:Ethanol