Effects of anti-inflammatory drugs on urinary excretion of prostaglandin metabolites in cotton pellet inflammation.
The influence of cotton pellet inflammation in rats and the effect of prednisolone and indomethacin on the excretion of the main urinary metabolite (MUM)s of prostaglandin (PG) F and E types were studied. After cotton pellet implantation, the excretion of PGE-MUM and F-MUM was progressively increased. In the early phase of inflammation, the excretion of PGE-MUM and PGF-MUM was suppressed by administration of indomethacin. However, prednisolone suppressed only PGF-MUM excretion in the early phase of inflammation. These results indicate that no direct interaction was obtained between the inhibition of the inflammatory response by prednisolone and indomethacin and PGs-MUM excretion in inflamed rats.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003368:Gossypium; D007249:Inflammation / Q000209:etiology / Q000652:urine*; D008297:Male; D011239:Prednisolone / Q000494:pharmacology; D011453:Prostaglandins / Q000652:urine*; D011458:Prostaglandins E / Q000652:urine; D011460:Prostaglandins F / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D011239:Prednisolone