Changes in hemopoiesis of mice of the C3H strain following transplantation of Gardner lymphosarcoma and infection with LDH-virus. II. Spleen and bone marrow.
Cytological examination of spleens of mice with growing Gardner lymphosarcoma contaminated with LDH virus indicates the augmentation of erythropoiesis and granulopoiesis, as well as the decrease of lymphopoiesis. Similar changes were observed after infection with LDH-virus. The counts from the bone marrow smear showed more pronounced changes only in tumorous mice, in which repeatedly increased granulopoiesis was found. When the mice bearing Gardner lymphosarcoma were treated with L-asparaginase, then the cytological findings in the spleens and marrows of femors were almost normal. The examination of spleen and bone marrow smears revealed no tumor cells. Histologically examined spleens of mice with 12-day-growing Gardner lymphosarcoma demonstrated infiltration of the follicles with tumor cells. In the marrow of sternum no infiltration of tumor cells could be established.
D000818:Animals; D001215:Asparaginase / Q000494:pharmacology; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D006410:Hematopoiesis; D007772:Lactate dehydrogenase-elevating virus; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000473:pathology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000097:blood / Q000473:pathology; D013154:Spleen / Q000473:pathology*; D014777:Virus Diseases / Q000097:blood / Q000473:pathology*
D001215:Asparaginase