title: [Pregnancies and offspring after MOPP therapy].
abstract: The influence of MOPP therapy on pregnancy and offspring was retrospectively studied by means of a questionnaire in 68 women who had been given 3 to 6 cycles of the drug combination for Hodgkin's disease between 1972 and 1976. All were aged from 16 to 45 years at the time of diagnosis; none had received abdominal irradiation. Before treatment, 72 pregnancies had occurred in 36 women; 31 children were born and 2 of these had minor congenital abnormalities. After treatment, 30 pregnancies were recorded in 22 of the 50 women who were still menstruating; 22 children were born, and only one had a minor congenital malformation; all children showed normal psychomotor development. It is concluded that MOPP does not seem to have any effect on fertility, pregnancy and offspring of those women (73,6%) who continue having menstruations after treatment.
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D005260:Female; D005298:Fertility / Q000187:drug effects; D005333:Fetus / Q000187:drug effects*; D006689:Hodgkin Disease / Q000188:drug therapy; D006801:Humans; D007231:Infant, Newborn; D008466:Mechlorethamine / Q000627:therapeutic use; D008599:Menstruation Disturbances / Q000139:chemically induced; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D011247:Pregnancy / Q000187:drug effects*; D011248:Pregnancy Complications / Q000139:chemically induced; D011344:Procarbazine / Q000627:therapeutic use; D012189:Retrospective Studies; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D011241:Prednisone
vernacular_title: Grossesses et progéniture après chimiothérapie MOPP.