Time of appearance and tissue distribution of a cell surface antigen in early chick development.
The distribution of the antigen defined by monoclonal antibody 224-1A6-A1 in the early chick embryo was studied. The antigen is unequivocally present in the rudimentary neural tube as early as the 12 somite stage (approximately 40 h of incubation). The antigen appears on some but not all derivatives of the ectoderm and mesoderm, but appears to be absent on endodermal derivatives. Monoclonal antibody 224-1A6-A1 therefore serves as a marker for early events in the developmental sequence leading toward the formation of the nervous system.
D000818:Animals; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis*; D001345:Autoradiography; D002642:Chick Embryo / Q000276:immunology*; D004475:Ectoderm / Q000276:immunology; D008648:Mesoderm / Q000276:immunology; D009420:Nervous System / Q000196:embryology* / Q000276:immunology; D014018:Tissue Distribution
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface