[A study of thyroid reserve in Hashimoto's disease (author's disease)].
A three-day thyroid stimulating hormone (TSH) test of administering 10 U.S.P. bovine TSH intramuscularly was performed on 6 normal subjects, 14 patients with Hashimoto's disease and 6 patients with primary hypothyroidism. The response of 24hr thyroidal 131I-uptake (131-uptake) and of serum thyroxine (T4) and triiodothyronine (T3) was studied in these subjects. Of the 14 patients with Hashimoto's disease, T4, T3 and TSH were normal in 5 patients (group 1); both T4 and T3 were normal and TSH was high in 5 patients (group 2); and either both T4 and T3 or one of them was low and TSH was high in 4 patients (group 3); 131I-uptake was normal in groups 1 and 2, and low in group 3. The mean increase in 131I-uptake was 33.7 +/- 11.4% (S.D.) in normal subjects, 22.8 +/- 5.6% in group 1, 4.4 +/- 5.0 in group 2, and no change in group 3 and primary hypothyroidism. The increase in T4 was 9.1 approximately 17/2 microgram /100ml in normal subjects, 3.7 approximately 6.1 microgram/100ml in group 1, 0 approximately 3.2 microgram/100ml in group 2, and no change in group 3 and primary hypothyroidism. Group 2 proved to be in the so-called condition of "low thyroid reserve" because 131I-uptake, T4 and T3, though normal before the test, failed to respond to TSH-stimulation, and endogenous TSH was increased in this group. in group 1, 131I-uptake responded to TSH-stimulation normally, but T4 and T3 did not. Group 1 seemed to be in the early stage of "low thyroid reserve".
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000378:metabolism; D013967:Thyroiditis, Autoimmune / Q000097:blood*; D013972:Thyrotropin / Q000494:pharmacology; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
D007457:Iodine Radioisotopes; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine