Evidence for late development of inhibition in area CA1 of the rat hippocampus.
Development of recurrent inhibition in area CA1 of the rat hippocampus was monitored by a paired-pulse stimulation test. Inhibition of the second response was never observed before postnatal day six. In addition, a type of epileptiform activity, referred to as spontaneous unison firing, was observed frequently, only on postnatal days 4 and 5. Together these observations suggest that the inhibitory interneuronal network of area CA1 becomes effective on about postnatal day 6.
D000375:Aging; D000818:Animals; D004553:Electric Conductivity; D004558:Electric Stimulation; D006624:Hippocampus / Q000254:growth & development / Q000502:physiology*; D066298:In Vitro Techniques; D011712:Pyramidal Tracts / Q000502:physiology*; D051381:Rats