The primary structure of porcine glicentin (proglucagon).
The primary structure of porcine glicentin has been established. The molecule consists of 69 amino acid residues and has a molecular weight of 8128. The sequence of glicentin 1-30 represents the glicentin-related pancreatic peptide (GRPP) previously isolated from porcine pancreas. The sequence 33-61 represents the full sequence of glucagon and the sequence 64-69 is a C-terminal hexapeptide. These three sequences, GRPP, glucagon and the hexapeptide are linked by two Lys-Arg pairs which probably represent the sites for post-synthetic enzymatic cleavages. Glicentin thus fulfils the structural requirements for being proglucagon.
D000595:Amino Acid Sequence; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D053771:Glicentin; D005934:Glucagon; D004763:Glucagon-Like Peptides; D008956:Models, Chemical; D008970:Molecular Weight; D010179:Pancreas / Q000032:analysis*; D010446:Peptide Fragments; D010455:Peptides; D052336:Proglucagon; D011498:Protein Precursors; D013552:Swine / Q000378:metabolism*
D010446:Peptide Fragments; D010455:Peptides; D011498:Protein Precursors; D052336:Proglucagon; D004763:Glucagon-Like Peptides; D053771:Glicentin; C031026:glicentin-related pancreatic peptide; C015236:glucagon-like-immunoreactivity; D005934:Glucagon