Protein degradation during preimplantation development of the mouse.
The half-lives of labelled proteins were determined for mouse preimplantation embryo stages from the germinal vesicle oocyte to the early blastocyst. While no significant differences were found among half-lives for 1-cell stages, or among half-lives for cleavage stages, a significant (P less than 0.05) 28% decrease in half-life was observed between the 1-cell and the cleavage stages. Labelled protein half-lives were 18.2 and 13.1 h for the 1-cell and cleavage stages respectively. Fertilization probably initiates this increase in protein degradation rate although no significant decrease was detected until after the first cleavage.
D000818:Animals; D001755:Blastocyst / Q000378:metabolism*; D002970:Cleavage Stage, Ovum / Q000378:metabolism; D047108:Embryonic Development; D005260:Female; D051379:Mice; D009865:Oocytes / Q000378:metabolism*; D010063:Ovum / Q000378:metabolism*; D011247:Pregnancy; D011506:Proteins / Q000378:metabolism*
D011506:Proteins