title: Antiinflammatory activity of two novel derivatives of prednisolone.
abstract: The antiinflammatory activity of two new steroids synthesized by modifying the 17 beta-ketol side chain of prednisolone to the glycolate and glyoxylate methyl esters has been investigated in the carrageenin pedal edema test in rats. The two ester derivatives retained anti-inflammatory potency, nearly equivalent to that of the parent compound, when administered subcutaneously at the site of inflammation. However, the glyoxylate ester, when administered by systemic route, showed a weaker suppression of inflammation. The glycolate ester showed a reverse trend in that it was more effective when it was administered by systemic route than when it was applied topically.
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents; D004487:Edema / Q000503:physiopathology; D007279:Injections, Subcutaneous; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; C025429:methyl prednisolonate; C025428:methyl 20-dihydroprednisolonate; D011239:Prednisolone