Regeneration of mammalian skeletal muscle following the injection of the snake-venom toxin, taipoxin.
Taipoxin, a toxin isolated from the venom of the snake Oxyuranus scutellatus was injected subcutaneously into the anterolateral aspect of one hind limb of the rat. The toxin caused a necrotising myopathy in the underlying muscle. The ultrastructural characteristics of the regeneration that followed the administration of the myotoxin were studied. Regeneration occurred within the surviving basal lamina tubes from a population of spared satellite cells. Myotubes were formed by 3 days and small immature muscle fibres by 5 days. The regenerative response was total and very rapid. Highly activated satellite cells were found in apparently undamaged fibres in the toxin-damaged muscles. Many of these cells appeared to be motile, having cytoplasmic processes which seemed to be passing through the basal lamina of the parent muscle fibres.
D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure; D004546:Elapid Venoms / Q000494:pharmacology*; D005260:Female; D008854:Microscopy, Electron; D009132:Muscles / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D009940:Organoids / Q000648:ultrastructure; D011554:Pseudopodia / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration; D012519:Sarcoplasmic Reticulum / Q000648:ultrastructure; D013997:Time Factors
D004546:Elapid Venoms; D009466:Neuromuscular Blocking Agents; C015523:taipoxin