title: Trace analysis of sulfaquinoxaline in animal tissues by high-performance liquid chromatography.
abstract: Sulfaquinoxaline (in combination with diaveridine as a potentiating agent) was administered orally to broilers, 4-5 weeks old, and sulfonamide residues were determined in muscle and liver at 0, 1, 2, 4, 6, 7, 8, and 10 days post-treatment, using ion-pair extraction followed by high-performance liquid chromatography with UV detection. Improved recoveries (ca. 80%, at the 10 ppb level) were obtained after liquefaction of the tissues by the addition of 8 M urea and sodium hydroxide, prior to ion-pair extraction. A withdrawal period of seven days was found necessary in order to reduce drug residues in muscle and liver to 10 ppb, a level without hazard to humans.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002645:Chickens; D002851:Chromatography, High Pressure Liquid; D008099:Liver / Q000032:analysis*; D008460:Meat / Q000032:analysis; D008832:Microchemistry; D009132:Muscles / Q000032:analysis*; D013424:Sulfanilamides / Q000032:analysis*; D013428:Sulfaquinoxaline / Q000032:analysis* / Q000378:metabolism; D013449:Sulfonamides / Q000302:isolation & purification
chemical_list: D013424:Sulfanilamides; D013449:Sulfonamides; D013428:Sulfaquinoxaline