[Biosynthesis of ribosomal RNA in rat liver cells after inhibition of protein synthesis].
Ribosomal RNA synthesis in starved rat liver cells after a single injection of sublethal dose of cycloheximide (3 mg per kg of body weight) was studied. An increase in the rate of nuclear ribosomal RNA synthesis was observed during the first 2 hours after cycloheximide injection followed by a noticeable decrease of synthesis by the 3rd hour. It was assumed that the stimulation of ribosomal RNA synthesis is correlated with the increase in the rate of transport from the cytoplasm to the nuclei of RNP proteins and of proteins involved in regulation of genome transcription.
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D003513:Cycloheximide / Q000494:pharmacology*; D005796:Genes / Q000187:drug effects; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D014176:Protein Biosynthesis / Q000187:drug effects*; D012335:RNA, Ribosomal / Q000235:genetics*; D051381:Rats; D012261:Ribonucleoproteins / Q000235:genetics; D014158:Transcription, Genetic / Q000187:drug effects*
D012335:RNA, Ribosomal; D012261:Ribonucleoproteins; D003513:Cycloheximide
Biosintez ribosomnykh RNK v kletkakh pecheni krysy pri podavlenii sinteza belkov.