[Effect of remantadine on the immunodepressive action of influenza virus].
Inoculation of mice with strains of influenza virus toxigenic or pathogenic for these animals resulted in significant inhibition of formation of the antibody-producing cells in response to inoculation with sheep erythrocytes. Inoculation of mice with influenza virus strains having no toxicity or pathogenicity for mice did not lead to the development of immunosuppression. The treatment of mice with remantadine prevented inhibition of formation of antibody-producing cells.
D000218:Adamantane / Q000031:analogs & derivatives*; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D007108:Immune Tolerance / Q000187:drug effects*; D007114:Immunization; D009980:Influenza A virus / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000382:microbiology; D012299:Rimantadine / Q000276:immunology*; D013997:Time Factors; D014776:Virus Cultivation
D012299:Rimantadine; D000218:Adamantane
Vliianie remantadina na immunodepressivnoe deĭstvie virusa grippa.