Effect of pregnenolone-16 alpha-carbonitrile on the biliary and urinary excretion of imipramine and some of its metabolites in rats.
The influence of pregnenolone-16 alpha-carbonitrile (PCN) upon the biliary and urinary excretion of unchanged imipramine and some of its metabolites was investigated in female rats. The substrate and its metabolites were identified and quantified by thin-layer chromatography and/or gas-liquid chromatography. PCN augmented urinary excretion of desipramine and the imipramine- and desipramine-glucuronides. PCN pretreatment also diminished the urinary elimination of imipramine N-oxide whereas proadifen hydrochloride had an inverse effect, suggesting a shift in the metabolic pathways of imipramine. The biliary excretion of the imipramine and desipramine glucuronides was not significantly altered by PCN.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D003891:Desipramine / Q000378:metabolism; D005260:Female; D007099:Imipramine / Q000378:metabolism* / Q000652:urine; D010084:Oxidation-Reduction; D011285:Pregnenolone Carbonitrile / Q000494:pharmacology*; D051381:Rats
D011285:Pregnenolone Carbonitrile; D007099:Imipramine; D003891:Desipramine