title: Pharmacokinetics of cyclophosphamide in Kenyan Africans.
abstract: The pharmacokinetics of cyclophosphamide was studied in 10 Kenyan Africans with Hodgkins lymphoma. The mean +/- s.d. elimination half-life (t1/2) was 7.5 +/- 1.38 h. The mean +/- s.d. volume of the central compartment (V1) was 0.35 +/- 0.12 l/kg and the apparent volume of distribution (V) was 0.64 +/- 0.06 l/kg. The microconstants k21, k12 and k10 were 1.81 +/- 0.84 h-1, 1.90 +/- 1.080 h-1 and 2.05 +/- 0.86 h-1 respectively (mean +/- s.d.).
mesh_terms: D000328:Adult; D003520:Cyclophosphamide / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D007630:Kenya; D007700:Kinetics; D008297:Male; D008875:Middle Aged
chemical_list: D003520:Cyclophosphamide