Prednisone-induced increase of proteinuria in patients with a nephrotic syndrome.
Administration of prednisone to patients with nephrotic syndromes of different aetiologies caused an abrupt increase of proteinuria. The proteinuric effect started four hours after oral or intravenous administration and reached its maximum effect after eight to sixteen hours. In nine patients with epimembranous glomerulopathy mean proteinuria on non-prednisone (NP) days was 43.7 per cent lower than on prednisone (P) days. Variations were significantly greater at higher creatinine clearances. However, in individual patients there were neither differences in creatinine excretion nor in creatinine clearance between P and NP days.
D000293:Adolescent; D000328:Adult; D000368:Aged; D005921:Glomerulonephritis / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects*; D011507:Proteinuria / Q000139:chemically induced*; D013997:Time Factors
D011241:Prednisone