title: Prevention of bacterial respiratory infection by an association of bacterial ribosomes and membranous proteoglycans. 2. Objective assessment of the response and of the immunological stimulation.
abstract: Using a vaccine preparation administered by aerosol for respiratory anti-infectious purposes and corresponding to the original formula of ribosomes and membrane fractions of microbial germs, the authors investigated during a period of nine months whether an objective, transient or lasting stimulation of the total and specific immunoglobulin (Ig) appeared. They provide a statistical analysis based on several serum Ig measurements and demonstrate the stimulant and lasting effect of the vaccine in the production of specific Ig for a sample of patients compared with controls. In those treated they observed apparently disordered variations of the serum levels of the total Ig, which in fact correspond to the initiation of a dynamic equilibrium in relation to the immunogenicity of the vaccine, the initial level of the total Ig and the production of the specific Ig. Finally, after a booster sequence carried out five month after "primary vaccination", they established the restarting of production of specific Ig accompanied this time by a different dynamic response of the total Ig.
mesh_terms: D000276:Adjuvants, Immunologic; D000328:Adult; D000336:Aerosols; D001426:Bacterial Proteins / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005163:Factor Analysis, Statistical; D005260:Female; D018073:Haemophilus Vaccines; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008565:Membrane Proteins / Q000276:immunology; D022242:Pneumococcal Vaccines; D011509:Proteoglycans / Q000276:immunology; D012141:Respiratory Tract Infections / Q000517:prevention & control*; D012270:Ribosomes / Q000276:immunology*; D022541:Streptococcal Vaccines; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D000336:Aerosols; D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D018073:Haemophilus Vaccines; D007136:Immunoglobulins; D008565:Membrane Proteins; D022242:Pneumococcal Vaccines; D011509:Proteoglycans; D022541:Streptococcal Vaccines; C024220:D 53