Metabolic clearance rate of rat prolactin in preweanling rat pups.
The metabolic clearance rate (MCR) of immunoreactive rat prolactin (rPRL) was determined in urethane-anaesthetized 14 to 16-day-old rat pups using the constant infusion to equilibrium method. Two different doses of rPRL were used, 329 and 472 ng/min each at a volume of 0.0025 ml/min for 30 min. The MCR was 0.216 ml/min following infusion of 329 ng PRL/min dose and 0.337 ml/min following infusion of the 472-ng/min dose. When calculated on the basis of metabolic body weight the MCR of rPRL in rat pups was comparable to that of adult rats.
D000367:Age Factors; D000818:Animals; D001835:Body Weight; D005260:Female; D008297:Male; D008657:Metabolic Clearance Rate; D011388:Prolactin / Q000097:blood*; D051381:Rats; D014886:Weaning
D011388:Prolactin