High incidence of renal tumors induced by N-dimethylnitrosamine in analbuminemic rats.
Analbuminemic rats were found to be highly susceptible to induction of renal tumors. Thirty-nine weeks after N-dimethylnitrosamine administration, the incidence of renal tumors and average weight of kidneys (including tumors) were 76.0% and 10.8 +/- 4.1 g in male analbuminemic rats, respectively, whereas they were 37.1% and 3.5 +/- 0.1 g, respectively, in normal male SD rats.
D000818:Animals; D004128:Dimethylnitrosamine; D007680:Kidney Neoplasms / Q000139:chemically induced*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D051381:Rats; D011922:Rats, Mutant Strains; D012709:Serum Albumin / Q000172:deficiency*
D012709:Serum Albumin; D004128:Dimethylnitrosamine