[Comparative evaluation of the effect of tuftsin and its analogs on immunogenesis].
The immunomodulator effect of tuftsin (Thr-Lys-Pro-Arg) and some analogs has been demonstrated on mice. All the peptides administered during the inductive phase of immunogenesis increased the content of antibody-producing cells in the spleen. Tuftsin and D-Arg-tuftsin appeared to be the most effective. The peptides did not affect the immune response under other application schemes.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects; D007114:Immunization; D007128:Immunoglobulin Fragments / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000276:immunology; D013997:Time Factors; D014405:Tuftsin / Q000276:immunology*
D007128:Immunoglobulin Fragments; D014405:Tuftsin
Sravnitel'naia otsenka vliianiia na immunogenez taftsina i nekotorykh ego analogov.