Regional inhibition of monoamine oxidase activity by administration of clorgyline in rat brain.
The inhibiting effect of monoamine oxidase (MAO) activities towards 5-hydroxytryptamine, dopamine and beta-phenylethylamine by an acute and chronic administration of clorgyline was investigated in five locations of the rat brain. Inhibiting the percentage distributed unevenly in each hypothalamic nucleus and in the circumventricular areas, except the median eminence, the percentages were significantly low as compared with the hypothalamic lateral nucleus. A significant percentage of inhibition for type B MAO towards beta-phenylethylamine was noticed in the chronically administered group. In conclusion, the MAO-inhibiting effect of clorgyline administered intraperitoneally was unevenly distributed in the discrete brain nuclei and the regional difference depended upon the dose and the duration of the clorgyline administration.
D000818:Animals; D003010:Clorgyline / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D007031:Hypothalamus / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008996:Monoamine Oxidase Inhibitors; D010296:Parietal Lobe / Q000187:drug effects* / Q000201:enzymology; D010627:Phenethylamines / Q000378:metabolism; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D013379:Substrate Specificity
D008996:Monoamine Oxidase Inhibitors; D010627:Phenethylamines; D011437:Propylamines; C029261:phenethylamine; D012701:Serotonin; D003010:Clorgyline; D004298:Dopamine