[Alcohol-induced lactic acidosis in thiamine deficiency].
Thiamine deficiency leads to a moderate hyperlactacidemia. As a result of an acute alcohol exposure the hyperlactacidemia is increased. In addition metabolic and respiratory acidosis with a distinct low pH value occurs. These changes constitute vital risks and may be considered as basic arguments for the explanation of sudden death in chronic alcoholics.
D000138:Acidosis / Q000097:blood / Q000139:chemically induced*; D000437:Alcoholism / Q000097:blood / Q000150:complications*; D000818:Animals; D006801:Humans; D007773:Lactates / Q000097:blood*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013832:Thiamine Deficiency / Q000097:blood / Q000150:complications*
D007773:Lactates
Alkoholinduzierte Lactatacidose bei Thiaminmangel.