Bu-2470, a new peptide antibiotic complex. II. Structure determination of Bu-2470 A, B1, B2a and B2b.
The structures of Bu-2470 A, B1, B2a, and B2b have been determined. Bu-2470 A is a simple octapeptide having no fatty acid moiety, while Bu-2470 B1, B2a and B2b are octapeptides that have been acylated with a beta-hydroxy C11 or C10 fatty acid. The octapeptide structure of Bu-2470 components was found identical with that of octapeptin C1, hence generic names of octapeptin C0, C2, C3 and C4 are proposed for Bu-2470 A, B1, B2a and B2b, respectively.
D000581:Amidohydrolases / Q000378:metabolism; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents; D002849:Chromatography, Gas / Q000379:methods; D002855:Chromatography, Thin Layer / Q000379:methods; D005227:Fatty Acids / Q000032:analysis; D055666:Lipopeptides; D009842:Oligopeptides; D010455:Peptides; D010456:Peptides, Cyclic; D011549:Pseudomonas / Q000201:enzymology; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D055666:Lipopeptides; D009842:Oligopeptides; D010455:Peptides; D010456:Peptides, Cyclic; C013629:octapeptin antibiotics; D000581:Amidohydrolases; C038758:polymyxin acylase