Invasive dysgerminoma in a girl with 45,X/46,X; mar mosaicism.
We report a 16-year-old girl with features of Turner's syndrome from whom an invasive dysgerminoma was removed. Cytotoxic drugs were given for the next 12 months. Mosaicism of two karyotypes (45,X/46,X; mar) was found in various tissues. The literature is reviewed with special regard to cytogenetic findings and prognosis of malignant growth and differentiation of dysgenetic gonads.
D000293:Adolescent; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004407:Dysgerminoma / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006059:Gonadal Dysgenesis; D006801:Humans; D007621:Karyotyping; D009030:Mosaicism; D010051:Ovarian Neoplasms / Q000150:complications* / Q000188:drug therapy; D014424:Turner Syndrome / Q000150:complications*; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide