[Pharmacokinetics of Taurolin].
In order to study the pharmacodynamics of taurolin (4,4'-methylene-bis(tetrahydro-2H-1,2,4-thiadiazine-1,1-dioxide) we labelled the substance in two different ways. 3*T contained 3 atoms of 14C, of which one served as a methylene bridge between the two ring systems. 4*T was labelled with 4 14C-atoms, two for every ring within the taurinamide part. Radioactivity was counted in blood, urine, faeces and expiration air of rats. For this purpose both labelled drugs were administered p.o., i.v. and i.p. After using 3*T radioactivity was excreted mainly by expiration, independently of the way of administration. The blood radioactivity diminished very slowly after a first short period. After administration of 4*T radioactivity was found mainly in the urine and only a small portion in the expiration air. Blood radioactivity diminished here very quickly. These results were confirmed by whole-body autoradiographic studies using 3*T as well as 4*T. No plasma-binding was found using the 4*T compound.
D000284:Administration, Oral; D000818:Animals; D001345:Autoradiography; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007700:Kinetics; D051381:Rats; D013654:Taurine / Q000031:analogs & derivatives*; D013829:Thiadiazines / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D013843:Thiazines / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution
D013829:Thiadiazines; D013843:Thiazines; D013654:Taurine; C012566:taurolidine
Uber die Pharmakokinetik von Taurolin.