Interaction of lipids with the plasma membrane of sperm cells. III. Antifusigenic effect by phosphatidylserine.
Addition of 10% phosphatidylserine to dipalmitoyl-phosphatidylcholine liposomes, containing 3H-cholesterol or 14C-phosphatidylcholine, inhibited interactions between liposomes and rabbit spermatozoa. Phosphatidylserine also caused an apparent decrease in the inhibitory effect of cholesterol-bearing liposomes on sperm fertilizing ability.
D000818:Animals; D002459:Cell Fusion / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects*; D002784:Cholesterol / Q000378:metabolism*; D008081:Liposomes / Q000378:metabolism; D008297:Male; D010718:Phosphatidylserines / Q000494:pharmacology*; D011663:Pulmonary Surfactants / Q000378:metabolism*; D011817:Rabbits; D013094:Spermatozoa / Q000187:drug effects*
D008081:Liposomes; D010718:Phosphatidylserines; D011663:Pulmonary Surfactants; D002784:Cholesterol