Distribution of the GC (group-specific component) subtypes in cord bloods and blood donors.
The common allele, GC/1, was subtyped into GC*IF and GC*IS by isoelectric focusing, increasing the proportion of heterozygotes from 0.42 to 0.58. In a series of 200 blood donors and 200 cord bloods the allele frequencies were found to be: GC*IS = 0.59, GC*IF = 0.11, GC*2 = 0.30; and GC*IS = 0.54, GC*IF = 0.16, GC*2 = 0.30, respectively. These values were similar to frequencies obtained in studies of other Caucasian populations. The average probability of detecting non-paternity for this population is increased from 17% to 30% after subtyping GC 1.
D000483:Alleles; D001315:Australia; D001788:Blood Grouping and Crossmatching; D002352:Carrier Proteins / Q000235:genetics* / Q000302:isolation & purification; D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010334:Paternity; D014809:Vitamin D-Binding Protein
D002352:Carrier Proteins; D014809:Vitamin D-Binding Protein