title: [System of methodological approaches to assessing and predicting the hemodynamic effects of hypotensive and antianginal agents].
abstract: A system of the methodological approaches to the assessment and prediction of hemodynamic effects of hypotensive and antianginal agents is proposed. The system includes the clinical and pharmacological tests in the population and twin studies with the use of the "partner control method", thereby allowing a comparative evaluation of the efficacy of the cardiovascular agents, prediction of their hemodynamic effects, and appraisal of the contribution of genetic and environmental factors to phenotypic variability of these effects.
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D003327:Coronary Disease / Q000188:drug therapy; D004200:Diseases in Twins; D004341:Drug Evaluation / Q000379:methods; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D011247:Pregnancy; D011379:Prognosis; D012044:Regression Analysis; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
chemical_list: D000959:Antihypertensive Agents; D002317:Cardiovascular Agents
vernacular_title: Sistema metodicheskikh podkhodov k otsenke i prognozirovaniiu gemodinamicheskikh éffektov gipotenzivnykh i antianginal'nykh sredstv.