Sodium balance and antidiuresis in thiazide-treated rats with diabetes insipidus.
A sodium deficit was induced in Brattleboro rats by lowering the dietary sodium content. Urine volume was only slightly reduced. Addition of hydrochlorothiazide to the food caused a small, transient sodium deficit but led to a marked, sustained antidiuresis. The acute administration of a large dose of hydrochlorothiazide produced a larger, sustained sodium deficit but no lasting antidiuresis. These results indicate that sodium depletion cannot account for the antidiuresis of hydrochlorothiazide treatment in diabetes insipidus.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003919:Diabetes Insipidus / Q000188:drug therapy / Q000378:metabolism*; D004039:Diet, Sodium-Restricted; D004231:Diuresis / Q000187:drug effects*; D006852:Hydrochlorothiazide / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D051381:Rats; D011910:Rats, Brattleboro; D012964:Sodium / Q000172:deficiency
D006852:Hydrochlorothiazide; D012964:Sodium