Synthesis and anticonvulsant screening of 3,3-diphenyl-2-pyrrolidone derivatives.
Six derivatives of 3,3-diphenyl-2-pyrrolidone were synthesized and screened for anticonvulsant activity. The synthetic route involved a mono-N-demethylation of an intermediate N,N-dimethylaminonitrile with methyl chloroformate followed by cleavage of the carbamate group. Of the six derivatives, (+/-)-2-imino-1,5-dimethyl-3,3-diphenylpyrrolidine hydrochloride was effective in protecting mice against maximal electroshock (MES) -induced seizures at a 30-mg/kg dose level.
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004597:Electroshock; D008297:Male; D051379:Mice; D009420:Nervous System / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000494:pharmacology
D000927:Anticonvulsants; D011760:Pyrrolidinones; D010433:Pentylenetetrazole