Depletion of glutathione content and inhibition of glutathione-S-transferase and aryl hydrocarbon hydroxylase activity of rat brain following exposure to styrene.
Dose dependent effects of styrene on cellular glutathione content and activity of cytosolic glutathione-S-transferase and microsomal aryl hydrocarbon hydroxylase of rat brain was investigated. A significant inhibition of aryl hydrocarbon hydroxylase and glutathione-S-transferase activity followed by depletion of glutathione content, was observed only at higher doses (450 and 900 mg/kg). Results suggest that exposure of styrene to rats can affect the biotransformation capacity of brain dependent on glutathione content and the activities of aryl hydrocarbon hydroxylase and glutathione-S-transferase.
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000037:antagonists & inhibitors*; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects*; D005978:Glutathione / Q000032:analysis*; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors*; D008297:Male; D051381:Rats; D013343:Styrenes / Q000009:adverse effects*
D013343:Styrenes; D001189:Aryl Hydrocarbon Hydroxylases; D005982:Glutathione Transferase; D005978:Glutathione