title: Effect of hyperventilation and starvation on rat lung mechanics and surfactant.
abstract: We studied the effects of hyperventilation and starvation on rat lung mechanics and surfactant. We hyperventilated lungs by excising and ventilating them at 3 times the normal tidal volume. Three days starvation reduced the alveolar pool of disaturated phosphatidyl choline by about 20% but did not significantly reduce the functional residual capacity. Air and saline deflation pressure-volume curves were performed in 4 groups: control lungs, lungs from starved rats, hyperventilated lungs, and hyperventilated lungs from starved rats. The area under each curve was calculated; this indicated the relative position of the curve in the pressure-volume diagram. We found that starvation did not change recoil, that hyperventilation increased surface recoil, and that combined starvation and hyperventilation increased it even more. We conclude that hyperventilation-induced dysfunction of surfactant is greater when the alveolar pool of surfactant is reduced by starvation. This effect might also occur clinically in the intensive care setting.
mesh_terms: D000399:Air Pressure; D000818:Animals; D004548:Elasticity; D008168:Lung / Q000378:metabolism / Q000503:physiopathology*; D008176:Lung Volume Measurements; D008297:Male; D011663:Pulmonary Surfactants / Q000378:metabolism*; D051381:Rats; D012121:Respiration, Artificial / Q000009:adverse effects*; D013217:Starvation / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D011663:Pulmonary Surfactants