Behavioral effects of buprenorphine and diprenorphine under a multiple schedule of food presentation in squirrel monkeys.
The effects of buprenorphine and diprenorphine were examined in squirrel monkeys responding under a multiple fixed-ratio, fixed-interval schedule of food presentation. Buprenorphine (0.003-1.0 mg/kg) produced dose-dependent decreases in rates of responding under both components of the multiple schedule. These effects of buprenorphine (greater than 0.03 mg/kg) were still apparent 1 and 2 days after administration. Diprenorphine decreased rates of responding in a manner similar to that of buprenorphine; however, diprenorphine was less potent than buprenorphine and its duration of action was shorter. Buprenorphine-induced decreases in rates of responding under both components of the multiple schedule were antagonized by naloxone (0.1-1.0 mg/kg), whereas those of diprenorphine were not. At 0.3 mg/kg of naloxone the buprenorphine dose-effect curve was shifted approximately 1 log U to the right. Buprenorphine did not antagonize morphine-induced decreases in rates of responding under the multiple schedule; however, effects of morphine were antagonized by both naloxone and diprenorphine. Finally, the effects of buprenorphine were not attenuated when buprenorphine was administered once daily for 17 days.
D000818:Animals; D002047:Buprenorphine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D004174:Diprenorphine / Q000494:pharmacology*; D004347:Drug Interactions; D005247:Feeding Behavior / Q000187:drug effects*; D009019:Morphinans / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D012453:Saimiri
D009019:Morphinans; D004174:Diprenorphine; D009270:Naloxone; D002047:Buprenorphine; D009020:Morphine