Steady-state distribution volume in physiologic multi-organ systems.
A unique definition of the apparent volume of distribution at steady-state is presented which is consistent with the realistic concept of blood concentration differences within the circulatory system. A physiologically based pharmacokinetic model consisting of eliminating and non-eliminating organs is used to predict the effect of drug elimination upon the steady-state distribution volume.
D006801:Humans; D007700:Kinetics; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D004364:Pharmaceutical Preparations