title: Efficacy of ivermectin against third-stage Dirofilaria immitis larvae in ferrets and dogs.
abstract: Ivermectin prevented maturation of Dirofilaria immitis when given per os to ferrets at a dosage of 0 X 1 mg ivermectin per kg bodyweight two days after inoculation with third stage heartworm larvae. Similar results were found in dogs treated one day after infection at a dosage of 0 X 05 mg ivermectin per kg. No heartworm were found in the hearts and lungs of five treated dogs compared to an average of 11 worms per dog in five control animals.
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D002335:Carnivora; D004183:Dirofilaria immitis / Q000187:drug effects*; D004184:Dirofilariasis / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D005289:Ferrets; D005369:Filaricides / Q000627:therapeutic use*; D005370:Filarioidea / Q000187:drug effects*; D007559:Ivermectin; D007783:Lactones / Q000627:therapeutic use*; D007814:Larva / Q000187:drug effects; D008297:Male
chemical_list: D000871:Anthelmintics; D005369:Filaricides; D007783:Lactones; D007559:Ivermectin