Application of the combined use of fused silica capillary columns and NPD for the toxicological determination of codeine and ethylmorphine in a human overdose case.
The applicability of capillary gas chromatography to the toxicological analysis of extracts of human tissue samples was investigated for codeine and ethylmorphine in a case of drug overdose. After column extraction, the samples were injected onto a fused silica capillary column, using a direct injection technique. The nitrogen-phosphorus detector provided excellent stability and sensitivity without the need for extensive clean-up procedures.
D000328:Adult; D002849:Chromatography, Gas / Q000379:methods*; D003061:Codeine / Q000032:analysis* / Q000506:poisoning; D005036:Ethylmorphine / Q000032:analysis* / Q000506:poisoning; D006801:Humans; D008297:Male; D009022:Morphine Derivatives / Q000032:analysis*; D010634:Phenobarbital / Q000506:poisoning; D019966:Substance-Related Disorders / Q000378:metabolism; D014020:Tissue Extracts / Q000032:analysis*
D009022:Morphine Derivatives; D014020:Tissue Extracts; D005036:Ethylmorphine; D003061:Codeine; D010634:Phenobarbital