[Prednisolone as a calcification inhibitor--a calciphylactic experiment in the rat pancreas].
In the experimental situation the inhibitory potency of prednisolone on soft tissue calcification is confirmed. This glucocorticoid was locally applied prior to the commencement of a mastocalciphylactic experiment (Selye). Dosage: 10 mg per animal, body mass 150-180 g. In 16 out of 17 female rats there were no calcified deposits in the interstitium of the pancreas but in nearly all of the control animals a typical calciphylactic reaction could be found. It is suggested that glucocorticoids act by alteration of pancreatic mast cells.
D000818:Animals; D002114:Calcinosis / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D010182:Pancreatic Diseases / Q000473:pathology / Q000517:prevention & control*; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D011239:Prednisolone; C021322:prednisolone hemisuccinate
Prednisolon als Inhibitor einer Verkalkung--ein Calciphylaxieversuch am Rattenpankreas.