title: Altered sensitivity of forebrain neurones to iontophoretically applied noradrenaline in aging rats.
abstract: Responses of unidentified neurones in the rostral cerebral cortex to iontophoretically applied noradrenaline and GABA were compared in young (3-4 months old) and old (22-24 months old) albino rats. Depressant responses to noradrenaline were smaller in the older animals and this was manifested particularly as a decrease in response duration. Depressant responses to GABA did not differ significantly in the two groups. The results indicate that neurones in the cerebral cortex, as in the cerebellum, exhibit a decrease in postsynaptic responsiveness to noradrenaline with advancing age.
mesh_terms: D000375:Aging; D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007478:Iontophoresis; D008297:Male; D009474:Neurons / Q000187:drug effects*; D009638:Norepinephrine / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D005680:gamma-Aminobutyric Acid; D009638:Norepinephrine