Non-steroidal anti-inflammatories--XII. Mode of action of anti-inflammatory methane sulfonanilides.
The influence of anti-inflammatory methane sulfonanilides on the arachidonic acid metabolism in ram seminal vesicle homogenate depends on the pK3 of the individual substance: more acidic compounds suppress, less acidic compounds stimulate PG synthesis and enhance the PGH2/PGG2 ratio. As oxygen radicals are liberated during the conversion of PGG2 to PGH2 it is suggested that the less acidic methane sulfonanilides are scavengers of the (pro-inflammatory) oxygen radicals.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008297:Male; D011448:Prostaglandin Antagonists; D011453:Prostaglandins / Q000096:biosynthesis; D012669:Seminal Vesicles / Q000378:metabolism; D012756:Sheep; D013449:Sulfonamides / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D013449:Sulfonamides