Determination of propranolol in peritoneal dialysis fluid by high-performance liquid chromatography without extraction.
A rapid, sensitive method for the high-performance liquid chromatographic determination of propranolol in peritoneal dialysis fluid is described. An extraction step is replaced by the use of a C18 Sep-Pak cartridge for sample preparation. The procedure offers an acceptable alternative to sample extraction and will allow for pharmacokinetic studies of propranolol in patients undergoing peritoneal dialysis for chronic renal failure.
D001202:Ascitic Fluid / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D007700:Kinetics; D010530:Peritoneal Dialysis; D011433:Propranolol / Q000032:analysis* / Q000378:metabolism / Q000627:therapeutic use
D011433:Propranolol