Body temperature response to cocaine and diazepam in morphine-treated rats.
Since cocaine or diazepam are used clinically and/or abused concomitantly with narcotics, this study was designed to determine if morphine-dependent, morphine-withdrawn, or acute morphine rats exhibit an altered core body temperature at 24 or 4 degrees C to either cocaine (10, 20, or 30 mg/kg i.p.) or diazepam (2 or 4 mg/kg i.p.). At 24 degrees C, each dose of cocaine manifested hyperthermia in all groups of rats except morphine-dependent whereas at 4 degrees C cocaine produced hypothermia in all groups except morphine-dependent. At both 24 and 4 degrees C, diazepam, 2 or 4 mg/kg, caused a hypothermic response in control, dependent, and withdrawn animals. At 24 degrees C, administration of acute morphine alone induced a hyperthermia which was antagonized by both doses of diazepam. At 4 degrees C, acute morphine alone induced an initial hypothermia followed by a hyperthermia; both doses of diazepam potentiated the hypothermic response to acute morphine. Thus, significant alterations in core body temperature may be induced following the administration of cocaine or diazepam to morphine-treated rats.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009021:Morphine Dependence / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology; D013696:Temperature; D013997:Time Factors
D009020:Morphine; D003042:Cocaine; D003975:Diazepam