title: Exocrine pancreatic hypersecretion in Brazilian alcoholics.
abstract: Thirty percent of alcoholic patients without clinical evidence of pancreatic or hepatic disease showed hypersecretion of pancreatic bicarbonate in all three test periods after stimulation with secretin and secretin-cholecystokinin, and an increased amount of protein in the duodenal aspirate of the first test period, probably due to ductal wash-out. This hypersecretion must be taken into account when the secretion or secretin-cholecystokinin tests of alcoholics are interpreted, and, indeed, may be useful in identifying possible early pancreatic dysfunction that precedes insufficiency and clinical symptoms.
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000503:physiopathology*; D001639:Bicarbonates / Q000378:metabolism; D001938:Brazil; D002766:Cholecystokinin; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007419:Intestinal Secretions / Q000032:analysis; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D010186:Pancreatic Function Tests; D010195:Pancreatitis / Q000503:physiopathology; D011506:Proteins / Q000378:metabolism; D012633:Secretin
chemical_list: D001639:Bicarbonates; D011506:Proteins; D012633:Secretin; D002766:Cholecystokinin