[Role of angiotensin II in the mechanisms of ethanol consumption regulation in rats].
The hypothalamohypophyseal and renin-angiotensin systems of rats were studied in health, during long-term alcoholization and formation of artificial alcohol motivation. It was disclosed that a single intracerebral administration of angiotensin-II had a long-term (for 1--2 weeks) inhibitory effect on alcohol consumption in rats. At the same time a decrease in the activity of the vasopressin-synthesizing neurosecretory cells of the hypothalamic supraoptic nucleus and Hering's bodies as well as compensatory activation of the peripheral parts of the renin-angiotensin system were demonstrated. Apparently, the inclusion of ethanol metabolites in the normal brain metabolism appreciably changes the role of angiotensin-II in hypothalamohypophyseal and renin-angiotensin system functions.
D000428:Alcohol Drinking; D000437:Alcoholism / Q000503:physiopathology; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D004326:Drinking / Q000187:drug effects; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012084:Renin-Angiotensin System / Q000187:drug effects; D013997:Time Factors
D000804:Angiotensin II
Rol' angiotenzina-II v mekhanizmakh reguliatsii potrebleniia étanola u krys.