title: Flubendazole: dose range and efficacy studies against common internal parasites of swine.
abstract: The anthelmintic spectrum of activity and efficacy of flubendazole, using pigs naturally infected with helminth parasites, were determined in 4 experiments, using 157 pigs. Flubendazole (1.5 mg/kg of body weight) mixed in feed or top-dressed on feed for 5 consecutive days was highly effective as an anthelmintic. This dosage level indicated 100% efficacy against mature Ascaris suum, Oesophagostomum dentatum, Trichuris suis, and Metastrongylus apri. There was 88% efficacy against Strongyloides ransomi and 85% efficacy against Stephanurus dentatus and immature Ascaris suum. There was some activity against Globocephalus sp and Macracanthorhynchus hirudinaceus, but insufficient numbers of these parasites were present to make an accurate assessment.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D005260:Female; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D008463:Mebendazole / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy*
chemical_list: D000969:Antinematodal Agents; D001562:Benzimidazoles; D008463:Mebendazole; C018945:flubendazole