Effect of inhibiting dolichol phosphate-mannose formation on the biosynthesis of the N-acetylglucosaminylpyrophosphoryl polyprenols by the retina.
Previously (Kean, E.L. (1982) J. Biol. Chem. 257, 7952-7954), it was shown that dolichol phosphate-mannose stimulated the formation of the N-acetylglucosamine-containing mono-, di- and trisaccharide intermediates of the dolichol pathway. Consistent with this activating role, the present report demonstrates that inhibition of the formation of dolichol phosphate-mannose by the antibiotics, showdomycin and diumycin, also blocked the stimulatory phenomenon.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002642:Chick Embryo; D004287:Dolichol Monophosphate Mannose / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D007700:Kinetics; D010743:Phospholipids / Q000494:pharmacology; D011103:Polyisoprenyl Phosphate Monosaccharides / Q000096:biosynthesis*; D011104:Polyisoprenyl Phosphate Oligosaccharides / Q000096:biosynthesis*; D011105:Polyisoprenyl Phosphate Sugars / Q000096:biosynthesis*; D012160:Retina / Q000187:drug effects / Q000378:metabolism*; D012787:Showdomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010743:Phospholipids; D011103:Polyisoprenyl Phosphate Monosaccharides; D011104:Polyisoprenyl Phosphate Oligosaccharides; D011105:Polyisoprenyl Phosphate Sugars; C026602:diumycin; D004287:Dolichol Monophosphate Mannose; C018439:N-acetylglucosaminylpyrophosphoryldolichol; D012787:Showdomycin