Ultrastructural changes in isolated rat hepatocytes exposed to different CCl4 concentrations.
Ultrastructural data are presented on time-course changes in isolated rat hepatocyte suspensions exposed either to 1.2 or 1.8 mM CCl4 for up to 1 h. The subcellular changes at the lower concentration, but not the higher, are shown to closely parallel those reported to occur in rat hepatocytes following ingestion of CCl4.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology*; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000648:ultrastructure*; D008112:Liver Glycogen / Q000032:analysis; D008854:Microscopy, Electron; D008871:Microvilli / Q000648:ultrastructure; D051381:Rats
D008112:Liver Glycogen