title: [Metabolism of the local anaesthetic fomocaine by rat liver mitochondria (author's transl)].
abstract: Fomocaine (Erbocain) is metabolized by different routes in rat and beagle. By highly purified rat liver mitochondria it was metabolized to its N-oxide only. The N-oxide was reduced to fomocaine by a reductase localised in the matrix or in the inner membrane of the mitochondria. C-Hydroxylation with subsequent conjugation reactions as well as oxidative N- or O-dealkylation found in intact animals were not observed in mitochondria.
mesh_terms: D000818:Animals; D001711:Biotransformation; D003640:Dealkylation; D004285:Dogs; D006900:Hydroxylation; D066298:In Vitro Techniques; D008930:Mitochondria, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D010647:Phenyl Ethers / Q000378:metabolism*; D051381:Rats
chemical_list: D010647:Phenyl Ethers; C100275:fomocain
vernacular_title: Biotransformation des Lokalanästhetikums Fomocain durch Rattenleber-Mitochondrien.