The preparation and determination of structure of benzylpenicilloyl compounds used in skin-testing for penicillin allergy.
The preparation of alpha-D-benzylpenicilloyl-n-propylamine and octa-epsilon-(alpha-D-benzylpenicilloyl)-octa-alpha-L-lysine are described. Their structures were established by chemical and spectroscopic evidence. Proton and carbon-13 nuclear magnetic resonance spectra of these two penicillin derivatives and some related compounds are provided. These compounds are useful in skin testing for penicillin allergy.
D006801:Humans; D006967:Hypersensitivity; D009682:Magnetic Resonance Spectroscopy; D010400:Penicillin G / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000276:immunology*; D012882:Skin Tests; D013329:Structure-Activity Relationship
D010400:Penicillin G