Nitrogen bridgehead compounds. 33. New antiallergic 4H-pyrido[1,2-a]pyrimidin-4-ones. 2.
A series of 9-hydrazono-4H-pyrido[1,2-a]pyrimidin-4-ones was prepared. The compounds were evaluated in the rat passive cutaneous anaphylaxis test for antiallergic activity. Structure-activity relationship studies revealed that the presence of a monosubstituted hydrazone moiety in position 9 and an unsubstituted 2-position are necessary for the intravenous activity.
D000818:Animals; D006835:Hydrazones / Q000138:chemical synthesis / Q000627:therapeutic use; D006967:Hypersensitivity / Q000188:drug therapy*; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000627:therapeutic use; D051381:Rats; D013329:Structure-Activity Relationship
D006835:Hydrazones; D011744:Pyrimidinones