[Study of membrane proteins in skeletal muscle of normal or dystrophic mice. Effects of isaxonine phosphate (author's transl)].
We compared plasma-membrane proteins of dystrophic and normal mouse skeletal muscle. The membrane protein concentrations were higher in dystrophic muscle than in normal muscle. The percentages of two of the protein bands on an SDS gel were different in normal and dystrophic muscle. Isaxonine (N-isopropyl-amino-2 pyrimidine) phosphate significantly increased plasma-membrane proteins in dystrophic muscle but not in normal muscle. The relative proportions of these two protein bands of dystrophic plasma membrane were modified by isaxonine phosphate. There was no change in the membrane proteins of normal muscle.
D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D009137:Muscular Dystrophy, Animal / Q000378:metabolism*; D011743:Pyrimidines / Q000494:pharmacology*
D008565:Membrane Proteins; D011743:Pyrimidines; C020375:isaxonine
Etude des protéines membranaires de muscle squelettique de souris normales et dystrophiques. Effet du phosphate d'isaxonine.