title: [Age-related blood pressure reaction in spontaneously hypertensive rats in passive orthostasis].
abstract: Blood pressure responses to tilting were studied in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) at different ages. The increase in blood pressure due to tilting was significantly higher in SHR with a developed hypertension (26 week-old) than in WKY rats of the same age, whereas the increase was not significantly different in SHR with a still developing hypertension (10 week-old), compared to WKY rats. Yet, even in 10 week-old SHR, there was a significantly higher increase after treatment with naloxone (0.4 mg/kg) then in WKY rats. Obviously, there are differences in the endogenous opiates between the 10 week-old SHR and WKY rats.
mesh_terms: D000375:Aging; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D011187:Posture; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009270:Naloxone
vernacular_title: Altersabhängige Blutdruckreaktion spontan hypertensiver Ratten bei passiver Orthostase.