Effect of vitamin E supplementation on serum and high-density lipoprotein-cholesterol in renal patients on maintenance hemodialysis.
A significant increase in high-density lipoprotein-cholesterol after the ingestion of short-term megadoses of vitamin E has been documented in the recent literature. No attempt has been made to examine the effect of vitamin E supplementation on the serum lipids in chronic renal patients undergoing maintenance hemodialysis. This patient group typically exhibits subnormal high-density lipoprotein-cholesterol levels which may be a factor responsible for their increased mortality rate from atherosclerosis. In the present study, seven male renal patients on dialysis were given 600 IU of vitamin E daily for 4 wk. The level of total, free, and esterified cholesterol and triglyceride in whole serum and high-density lipoprotein were measured pre- and postregimen. No significant change was noted in any of the parameters examined for the group as a whole. Our results suggest that short-term high-dose vitamin E ingestion is unlikely to benefit the majority of renal patients on maintenance hemodialysis in regards to their circulating levels of high-density lipoprotein-cholesterol.
D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood*; D002788:Cholesterol Esters / Q000097:blood; D008076:Cholesterol, HDL; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy*; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014280:Triglycerides / Q000097:blood*; D014810:Vitamin E / Q000627:therapeutic use*
D002788:Cholesterol Esters; D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D014280:Triglycerides; D014810:Vitamin E; D002784:Cholesterol