[Electrocardiographic changes in the rat induced by high doses of the coenzymatic forms of several vitamins of the B group].
No modification, neither immediate nor late, was observed after the intravenous injection of high doses of the coenzymatic forms of thiamine and pyridoxine. On the contrary, after the injection of high doses of the coenzyme A, a sudden, conspicuous and brief (20-25") diminution of heart rate was observed. Such a phenomenon was much more marked and longer if, before the coenzyme A, a digitalic compound (desacetil-lanatoside C or digitoxin) was administered.
D000818:Animals; D003065:Coenzyme A / Q000494:pharmacology; D004071:Digitalis Glycosides / Q000494:pharmacology; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D011736:Pyridoxine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013831:Thiamine / Q000494:pharmacology*
D004071:Digitalis Glycosides; D011736:Pyridoxine; D003065:Coenzyme A; D013831:Thiamine
Modificazioni dell'elettrocardiogramma del ratto per azione di alte dosi delle forme coenzimatiche di alcune vitamine del gruppo B.