title: Magnesium and zinc deficiency and growth retardation in offspring of alcoholic rats.
abstract: Alcohol ingestion during pregnancy is known to cause fetal malformation and growth retardation. We investigated the effect of alcohol on mineral content and fetal development in rats fed 24% (v/v) alcohol eight weeks prior to and during pregnancy. Rats ingesting alcohol produced fewer fetuses (6.3 +/- 0.3 vs 9.6 +/- 0.3 in control) with lower fetal weight (3.48 +/- 0.09 vs 4.12 +/- 0.08 gm in control) and heavier placentas (0.66 +/- 0.05 vs 0.50 +/- 0.01 gm in control). The fetuses of alcoholic rats contained lower zinc (423.8 +/- 4.5 vs 459.9 +/- 5.4 microEq/100 gm dry weight in control) and magnesium (12.4 +/- 0.1 vs 12.7 +/- 0.1 mEq/100 gm dry weight in control) in the total carcass.
mesh_terms: D000437:Alcoholism / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D004573:Electrolytes / Q000378:metabolism; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000378:metabolism*; D005317:Fetal Growth Retardation / Q000209:etiology*; D005333:Fetus / Q000378:metabolism; D006801:Humans; D008274:Magnesium; D008275:Magnesium Deficiency / Q000209:etiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000172:deficiency* / Q000378:metabolism
chemical_list: D004573:Electrolytes; D008274:Magnesium; D015032:Zinc