Dynamic theory of leucocyte adhesion.
Leucocyte chemotaxis in in vitro chambers is analysed by applying the theory of transient diffusion to the chemotactic agent. This illustrates that use of physical principles can help in the interpretation of such experiments. A fluid-dynamical background is sketched for analysis of the dynamics of leucocyte adhesion in flow through blood vessels: this background includes the flow field induced around a particle in a velocity gradient. Discussion of the dynamics of leucocyte adhesion centres on estimation of the wall collisional rate of leucocytes from the bloodstream and leads to questions concerning measurement of collision efficiency. Specific experiments to elucidate factors remaining in question are suggested.
D001783:Blood Flow Velocity; D001808:Blood Vessels / Q000502:physiology; D002448:Cell Adhesion; D002465:Cell Movement; D002634:Chemotaxis, Leukocyte; D004058:Diffusion; D007962:Leukocytes / Q000502:physiology*; D012212:Rheology; D013997:Time Factors