Functional dissociation between lateral and medial entorhinal cortex in memory processes in mice.
The effects of lesions of the medial or the lateral entorhinal cortex in mice were examined on acquisition, retention and extinction of an operant-conditioning task in a Skinner box. Compared with the control animals, lesions in the medial entorhinal had no behavioral effects whereas lesions in the lateral entorhinal enhanced retention and increased resistance to extinction but did not change acquisition of this task. These results suggest a functional dissociation between the two parts of the entorhinal cortex.
D000818:Animals; D003216:Conditioning, Operant / Q000502:physiology; D004292:Dominance, Cerebral / Q000502:physiology; D005108:Extinction, Psychological / Q000502:physiology; D008032:Limbic System / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D012153:Retention, Psychology / Q000502:physiology