title: [Enzyme activity changes in chronic alcoholic intoxication and the simultaneous administration of pyridoxine].
abstract: After prolonged application of ethanol the liver and brain of rats show an appreciable increase in lactate dehydrogenase activity, noticeable lowering of cytoplasmic aspartate and alanine aminotransferase activity, elevation of liver arginine succinate lyase activity with unchanged activities of other enzymes of the ornithine cycle (ornithine carbamoyltransferase and arginase), reduction of glutamate and malate dehydrogenase and mitochondrial aspartate aminotransferase activity in brain tissue. Concurrent application of ethanol and pyridoxine normalizes the effect of ethanol on liver arginine succinate lyase and on brain tissue lactate and malate dehydrogenase, mitochondrial and cytoplasmic aspartate aminotransferase and alanine aminotransferase.
mesh_terms: D000437:Alcoholism / Q000201:enzymology*; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology; D050260:Carbohydrate Metabolism; D002952:Citric Acid Cycle; D006801:Humans; D008099:Liver / Q000201:enzymology; D008297:Male; D009952:Ornithine / Q000378:metabolism; D011736:Pyridoxine / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D000596:Amino Acids; D009952:Ornithine; D011736:Pyridoxine
vernacular_title: Izmeneniia aktivnosti nekotorykh fermentov pri khronicheskoĭ alkogol'noĭ intoksikatsii i odnovremennom vvedenii piridoksina.