title: Diagnosis of chordoma by cytologic examination of cerebrospinal fluid.
abstract: This is a case report of a 44-year-old man with a chordoma of the clivus that caused dysphonia, low back pain, and urinary and fecal incontinence. The diagnosis was made by cytologic study of the CSF, which demonstrated vacuolated malignant cells. The patient was treated with intrathecal methotrexate, dexamethasone, and radiotherapy. At autopsy extensive dissemination of chordoma was found at the base of the brain, in the ventricles, and in the leptomeninges of the spinal cord. This is the sixth reported case of intrathecal dissemination of a chordoma and the first diagnosed by cytology of the cerebrospinal fluid.
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000473:pathology; D002467:Cell Nucleus / Q000648:ultrastructure; D002555:Cerebrospinal Fluid / Q000166:cytology*; D002817:Chordoma / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008297:Male; D014617:Vacuoles / Q000648:ultrastructure