Doxorubicin in pregnancy: possible transplacental passage.
Two pregnant women with lymphoproliferative disorders were treated with doxorubicin-containing regimens. Both patients delivered shortly after a dose of doxorubicin. One child was healthy and the other was stillborn. Measurements of anthracycline levels in placental, cord, and fetal tissues by high-performance liquid chromatography suggest that doxorubicin may be transported across the placenta.
D000328:Adult; D004317:Doxorubicin / Q000009:adverse effects / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005313:Fetal Death / Q000139:chemically induced; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D008223:Lymphoma / Q000188:drug therapy*; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*
D004317:Doxorubicin