Anti tumour and pharmacological effects of the oil from Semecarpus anacardium Linn. f.
Semecarpus anacardium Linn.f. nuts were extracted by using non-polar and polar organic solvents. Hot methanol extract and a resinous fraction, isolated from it, showed antitumour activity against P388 lymphocytic leukaemia in BDF1 mice as judged by their median survival time. Petroleum ether extract and its chromatographically isolated fraction were obtained. The latter fraction was distilled under reduced pressure to get an orange-coloured oil, (b.p. 200-20 degrees/2-3 mm). Both had antitumour activity. The orange-coloured oil, on further distillation under reduced pressure, yielded Bhilawanol. An acetyl derivative of the oil was also obtained. The latter two also had antitumour activity.
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D009821:Oils / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D009821:Oils; D010936:Plant Extracts