Effect of the calcium antagonistic agent nifedipine on platelet aggregation response to exercise in patients with angina pectoris.
Angina pectoris patients were divided into two groups of unstable angina and stable angina, platelet aggregation was measured at rest and after treadmill exercise tolerance, and then the effects before and after the administration of nifedipine (Adalat) were examined. As a result, no significant difference in platelet aggregation at rest was seen in either group between before and after the administration of nifedipine, but the acceleration of platelet aggregation response to exercise was significantly inhibited by nifedipine. Moreover, the extent of inhibition was more notable in unstable angina group. It was discussed that such an inhibitory effect of nifedipine on platelet aggregation response to exercise could be related to vasospasm and in its turn possibly takes part in the development of myocardial ischemia.
D000328:Adult; D000787:Angina Pectoris / Q000097:blood*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology*; D005082:Physical Exertion; D010974:Platelet Aggregation / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D011725:Pyridines; D009543:Nifedipine