Effect of verapamil on allergen-induced asthma in patients with respiratory allergy.
Specific degranulation of mast cells and basophils depends upon transmembrane calcium flow. In the present studies the protective effect of the calcium-antagonist drug verapamil against allergen-induced asthma was assessed in eight atopic patients. The results of this study showed that verapamil, administered both orally or by aerosol, can prevent the specific bronchoconstriction.
D000284:Administration, Oral; D000328:Adult; D000336:Aerosols; D000485:Allergens / Q000276:immunology*; D001249:Asthma / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D001491:Basophils / Q000276:immunology; D001985:Bronchial Provocation Tests; D003594:Cytoplasmic Granules; D006801:Humans; D011058:Pollen / Q000276:immunology; D012130:Respiratory Hypersensitivity / Q000188:drug therapy*; D014700:Verapamil / Q000008:administration & dosage / Q000627:therapeutic use*; D014797:Vital Capacity / Q000187:drug effects
D000336:Aerosols; D000485:Allergens; D014700:Verapamil