Influence of the thyroid and parathyroid glands on magnesium metabolism during mineralocorticoid treatment (DOCA + NaCl) in the rat.
The aim of the study was to investigate changes in the magnesium balance in DOCA + NaCl (S)-treated rats and the role of the parathyroid and thyroid glands in these changes during such treatment. A large loss of magnesium in the urine is observed during the onset of DOCA + S treatment, but the magnesium balance was higher after 3 weeks of treatment than in normal untreated rats. DOCA + S treatment provoked the same magnesium losses in the urine of rats without a parathyroid gland and without a thyroid gland. However, the magnesium balance was higher in rats still possessing their thyroid gland. Thus, it appears that the thyroid gland is necessary to provoke a gain in the magnesium balance during mineralocorticoid treatment.
D000818:Animals; D001835:Body Weight; D003900:Desoxycorticosterone / Q000494:pharmacology*; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D010280:Parathyroid Glands / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000494:pharmacology; D013961:Thyroid Gland / Q000502:physiology*; D013965:Thyroidectomy; D013997:Time Factors
D003900:Desoxycorticosterone; D012965:Sodium Chloride; D008274:Magnesium