Cross-tolerance between ethanol and levorphanol with respect to stimulation of plasma corticosterone.
Male rats chronically intoxicated with ethanol for at least two days were tolerant to the ethanol-induced stimulation of hypothalamic-pituitary-adrenal axis. Chronically intoxicated rats also were tolerant to stimulation of this axis by levorphanol but not by amphetamine or ether. In a similar manner, animals treated with levorphanol for two days were tolerant to stimulation of the hypothalamic-pituitary-adrenal axis by either levorphanol or ethanol. These observations provide further support for the hypothesis that endogenous opioids may be involved in the development of tolerance to ethanol.
D000437:Alcoholism / Q000097:blood; D000818:Animals; D003345:Corticosterone / Q000097:blood*; D004361:Drug Tolerance; D004723:Endorphins / Q000502:physiology; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D007981:Levorphanol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013395:Sucrose / Q000494:pharmacology
D004723:Endorphins; D007981:Levorphanol; D000431:Ethanol; D013395:Sucrose; D003345:Corticosterone