Hypolipidemic activity of substituted 2-pyrrolidinones in rodents.
A series of substituted 2-pyrrolidinones was evaluated for hypolipidemic activity at 20 and 30 mg/kg/day in CF1 male mice. 4-Phenyl-5,5-dicarbethoxy-2-pyrrolidinone was the most potent compound at 30 mg/kg/day, reducing serum triglyceride levels 52% after 14 days of dosing and serum cholesterol levels 48% after 16 days of dosing. 4-Phenyl-5-carbethoxy-2-pyrrolidinone and 4-phenyl-3,5,5-tricarbethoxy-2-pyrrolidinone also demonstrated significant activity. Those compounds which contained a phenyl substituent were more potent than either the unsubstituted, the alkyl, or the dicarbethoxy 2-pyrrolidinone analogues.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002784:Cholesterol / Q000097:blood; D000960:Hypolipidemic Agents / Q000138:chemical synthesis*; D008297:Male; D051379:Mice; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
D000960:Hypolipidemic Agents; D011760:Pyrrolidinones; D014280:Triglycerides; D002784:Cholesterol