title: [DNA-repair of lymphocytes during PUVA-treatment (author's transl)].
abstract: In 20 psoriatic patients under PUVA maintenance treatment blood samples had been collected imediately before and after the UVA irradiation. The DNA-repair activity has been determined in the isolated lymphocytes by the incorporation of 3H-thymidine during the first 3 h (inhibition of the semiconservative replication by hydroxyurea). There is evidence for an increased repair activity in the lymphocytes after PUVA treatment whereas the lymphocytes exposed only to 8-MOP (before UVA irradiation) show lower values. The difference is statistically significant 45 and 90 min after irradiation, but not any more after 3 h.
mesh_terms: D004260:DNA Repair; D005260:Female; D011564:Furocoumarins / Q000627:therapeutic use*; D006801:Humans; D008214:Lymphocytes / Q000502:physiology*; D008297:Male; D010778:Photochemotherapy; D011565:Psoriasis / Q000097:blood / Q000188:drug therapy*
chemical_list: D011564:Furocoumarins
vernacular_title: DNA-Reparatur von Lymphocyten unter PUVA-Behandlung.