Nutritional prevention of pre-eclampsia--a special role for 1 series prostaglandin precursors?
PGE1 appears to act as a physiological regulator of uteroplacental blood flow. Its vasodilatory, anti-vasopressor, and platelet stabilizing effects could be expected to counteract the placental ischemia, hypertension and excessive coagulation that are seen in pre-eclampsia. Supplementation with efficient essential fatty acid precursors of PGE1 reduces platelet aggregation, has been used with success in the treatment of hypertension and arterial vasospasm, and might offer a nutritional means of reducing the incidence and severity of pre-eclampsia. Assurance of adequate general nutrition also appears to be of importance in this regard.
D000527:Alprostadil; D000818:Animals; D004211:Disseminated Intravascular Coagulation / Q000517:prevention & control; D005228:Fatty Acids, Essential / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D009751:Nutritional Requirements; D010920:Placenta / Q000098:blood supply; D010974:Platelet Aggregation / Q000187:drug effects; D011225:Pre-Eclampsia / Q000517:prevention & control*; D011247:Pregnancy; D011458:Prostaglandins E / Q000096:biosynthesis*; D014664:Vasodilation
D005228:Fatty Acids, Essential; D011458:Prostaglandins E; D000527:Alprostadil