In vitro and in vivo inhibition of [3H]imipramine binding by cadmium.
Chronic exposure of rats to CdCl2 altered the specific binding of [3H]imipramine to membranes from platelets and hypothalamus. There was a decrease in Bmax of 10-40% and a decrease in KD values of 30-40% as compared to the control group. In vitro studies on the inhibition of [ 3H ]imipramine binding to membranes from human and rat platelets and hypothalamus by CdCl2 corroborate the in vivo results which imply that the imipramine binding protein contains Cd2+-sensitive groups.
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D002104:Cadmium / Q000494:pharmacology*; D002462:Cell Membrane / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D007099:Imipramine / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008566:Membranes / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D002104:Cadmium; D007099:Imipramine