Postpartum exposure to triethyl tin produces long-term alterations in responsiveness to apomorphine.
Male and female rat pups were exposed to a single dose of triethyl tin (TET) or ethanol vehicle on day 5 postnatally and tested for responsiveness to apomorphine as adults. TET-exposed animals displayed an increased response to the stereotypic effects of 1 mg/kg of apomorphine. Female rats exposed neonatally to TET had decreased baseline rates of responding on a food reinforced variable interval (VI) 15 sec. schedule, while TET-exposed males were found to have increased baseline rates relative to controls. The rats maintained on a VI 15 sec. schedule were given various doses of apomorphine (0.0312-0.25 mg/kg, s.c.). Neonatal exposure to TET had no effect on the disruptive effects of apomorphine on VI 15 sec. responding. These data show an altered responsiveness of TET-exposed animals to higher doses of apomorphine (1 mg/kg), but not to lower doses of apomorphine (0.0312-0.25 mg/kg). The present data are in accord with the hypothesis that one of the long-term consequences of neonatal exposure to TET might be an alteration in the responsiveness of the dopamine system.
D000818:Animals; D000831:Animals, Newborn; D001058:Apomorphine / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012737:Sex Factors; D013239:Stereotyped Behavior / Q000187:drug effects; D014220:Trialkyltin Compounds / Q000009:adverse effects*; D014267:Triethyltin Compounds / Q000009:adverse effects*
D014220:Trialkyltin Compounds; D014267:Triethyltin Compounds; D001058:Apomorphine