IgM autoantibody to intermediate filaments in infectious mononucleosis.
Sera from 17 patients with infectious mononucleosis reacted with fine cytoplasmic fibrils in monolayer cultures of fibroblasts. In cells pre-treated with vinblastine, the sera reacted with peri- or juxta-nuclear coils of filaments. These staining patterns were similar to those obtained by anti-intermediate filament autoantibody but different from the "actin-cables" stained by anti-actin autoantibody and from the "tubulin paracrystals" stained by anti-microtubule autoantibody. The autoantibodies belonged to the IgM class and ranged in titre from 1 : 16 to 1:512 (mean 1:64). A change in antibody titre was noted in sequential acute and convalescent sera. The results show that IgM autoantibodies to intermediate filaments occur frequently in sera from patients with infectious mononucleosis.
D000199:Actins / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis / Q000276:immunology*; D003599:Cytoskeleton / Q000276:immunology*; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D007244:Infectious Mononucleosis / Q000276:immunology*; D007668:Kidney / Q000276:immunology; D008297:Male; D051379:Mice; D009130:Muscle, Smooth / Q000276:immunology; D011817:Rabbits; D051381:Rats; D013270:Stomach; D014404:Tubulin / Q000276:immunology; D014747:Vinblastine / Q000494:pharmacology
D000199:Actins; D001323:Autoantibodies; D007075:Immunoglobulin M; D014404:Tubulin; D014747:Vinblastine