title: Netilmicin in human CSF after parenteral administration in patients with slightly and severely impaired blood CSF barrier.
abstract: After administration of 150 mg netilmicin samples of CSF and blood were obtained. In one group of nine patients with no or only slight impairment of the blood-CSF-barrier 29 samples of CSF were assayed for netilmicin concentrations. All samples, obtained after the first dose, failed to reveal detectable drug levels. Drug levels up to 0.18 mg/l were detected in samples of CSF of three patients after 3 to 22 doses. Only the lumbar CSF of one patient contained netilmicin concentrations higher than 1.0 mg/l. In comparison 19 samples of CSF, obtained from patients with meningitis after more than one dose of netilmicin, had levels of 0.27-5.0 mg/l. Three CSF samples from patients out of this group, collected after the first dose of netilmicin failed to show any drug activity.
mesh_terms: D000328:Adult; D000368:Aged; D001812:Blood-Brain Barrier; D005839:Gentamicins / Q000134:cerebrospinal fluid*; D006801:Humans; D008581:Meningitis / Q000188:drug therapy; D008875:Middle Aged; D009428:Netilmicin / Q000008:administration & dosage / Q000134:cerebrospinal fluid*
chemical_list: D005839:Gentamicins; D009428:Netilmicin