Effects of alcohol on thermoregulation in aged monkeys.
Ethanol ingestion has been implicated in accidental hypothermia of the elderly, but there is no prior data on the relative sensitivity to alcohol of aged homeotherms that might account for disproportionate dysthermia in this age group. To assess their sensitivity, ethanol (0.5-2.0 g/kg) or H20 was given by gavage to squirrel monkeys less than 4 yrs old, 4-9 yrs of age and over 9 yrs old. Dose-related decreases in body temperature occurred in all three groups in a 25.5 degrees C environment, with the greatest decreases in the oldest animals. In an 18.5 degrees C environment the hypothermias caused by 0.5 and 1.0 g/kg ethanol were greatly augmented in old monkeys and in some cases their temperatures fell to potentially life-threatening levels. In a 30.5 degrees C environment, 1.0 g/kg ethanol given to monkeys caused approximately equal temperature reductions in the three groups. When determined after 1.0 g/kg ethanol, peripheral vasomotor tone increased significantly in animals of each age group in all three environments. Decreases in rectal temperature were associated with parallel decreases in oxygen consumption. These results indicate that: 1) aging is associated with an increased sensitivity to the hypothermic action of ethanol in thermoneutral and cold environments, 2) ethanol in the doses tested inhibits heat production mechanisms without suppressing compensatory vasoconstriction in response to decreased body temperature.
D000375:Aging; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001833:Body Temperature Regulation / Q000187:drug effects*; D003080:Cold Temperature; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006358:Hot Temperature; D007035:Hypothermia / Q000139:chemically induced; D008297:Male; D012007:Rectum; D012453:Saimiri; D012881:Skin Temperature / Q000187:drug effects; D013997:Time Factors
D000431:Ethanol