Assessment of nonsteroidal anti-inflammatory drug combinations by the polyurethane sponge implantation model in the rat.
The anti-inflammatory effect of single doses and combinations of aspirin and commonly used nonsteroidal anti-inflammatory drugs was investigated by the polyurethane sponge implantation model of acute inflammation. Dose response curves were performed to delineate a suppressive (high) and nonsuppressive (low) dose of each drug prior to studying these doses in combination with aspirin. The results suggest that a combination of aspirin in either high or low dose does not increase the anti-inflammatory effect of other nonsteroidal anti-inflammatory drugs in this model of inflammation.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D007249:Inflammation / Q000188:drug therapy*; D011140:Polyurethanes; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D011140:Polyurethanes; C028279:polyurethane foam; D001241:Aspirin