Effects of orchidectomy and dihydrotestosterone on the choline acetyltransferase activity of specific rat brain areas.
1. The choline acetyltransferase (ChAT) activity of specific brain areas was determined in adult intact, orchidectomized and dihydrotestosterone (DHT)-treated orchidectomized rats. 2. Results show that orchidectomy decreased ChAT activity in most brain areas studied. 3. However, DHT treatment of orchidectomized animals increased ChAT activity only in the cerebral cortex.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002369:Castration; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D013196:Dihydrotestosterone / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D013196:Dihydrotestosterone; D002795:Choline O-Acetyltransferase