[Action of the "delta-sleep peptide" on monoamine oxidase and acetylcholinesterase activity in subcellular fractions from different rabbit brain formations in vivo].
Administration of delta-sleep-inducing peptide (DSIP) in vivo in a dose of 30 microgram/kg bw brings about MAO-A (substrate-serotonin) activation in synaptosome subfractions and cellular mitochondria from the brain structures (motor cortex, nucleus caudatus, thalamus). Activity of MAO-B (substrate-p-nitrophenylethylamine) and acetylcholinesterase was inhibited negligibly and specifically in subcellular fractions of the test brain structures. The results suggest that DSIP effects the regulatory or modulation function in the synapse. As one of the elements of sleep mechanisms this peptide induces a number of processes, particularly in serotonin metabolism.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D003701:Delta Sleep-Inducing Peptide; D008995:Monoamine Oxidase / Q000378:metabolism*; D009842:Oligopeptides / Q000494:pharmacology*; D011817:Rabbits; D013347:Subcellular Fractions / Q000187:drug effects / Q000201:enzymology
D009842:Oligopeptides; D003701:Delta Sleep-Inducing Peptide; D008995:Monoamine Oxidase; D000110:Acetylcholinesterase
Deistvie "peptida del'ta-sna" na aktivnost' monoaminooksidazt u atsetilkholinésterazy v subkletochnykh fraktsiiakh iz razlichnykh obrazovaniĭ mozga krolika in vivo.