Mutagenicity of nitropyrenes in Chinese hamster V79 cells.
The mutagenic effects of 1-nitropyrene, and 1,3- and 1,8-dinitropyrenes on Chinese hamster V79 cells in the presence or absence of X-irradiated Syrian hamster embryo cells were examined. Without Syrian hamster embryo cells, 1,3-dinitropyrene had weak mutagenic activity and 1,8-dinitropyrene had strong, dose-related mutagenic activity. With Syrian hamster embryo cells, the mutagenicities of both 1,3-and 1,8-dinitropyrenes were appreciably increased. 1-Nitropyrene did not induce ouabain-resistant mutants at concentrations of up to 10 micrograms/ml either with or without Syrian hamster embryo cells.
D000818:Animals; D001711:Biotransformation; D006224:Cricetinae; D003412:Cricetulus; D008647:Mesocricetus; D009153:Mutagens / Q000378:metabolism; D010042:Ouabain / Q000494:pharmacology; D011721:Pyrenes / Q000633:toxicity*
D009153:Mutagens; D011721:Pyrenes; C033310:1,8-dinitropyrene; D010042:Ouabain; C037413:1,3-dinitropyrene; C032668:1-nitropyrene