title: Effect of infant formuLas on blood and tissue cholesterol, bone calcium, and body composition in weanling pigs.
abstract: Weanling pigs were fed four commercial infant formulas to determine effects on blood and tissue cholesterol parameters and on body composition. Two milk protein (MP)-based formulas and two soy protein isolate (SPI)-based isocaloric formulas were fed in concentrated liquid form for 32 days. A commercial sow's milk replacer fed to a fifty group of pigs served as a control diet. Pigs fed SPI-based formula had significantly less cholesterol in the plasma than did pigs fed MP-based formula. Whole-body and adipose tissue cholesterol concentrations were greatest in  pigs fed formulas containing a relatively high concentration of polyunsaturated fatty acids (PUFA). Liver cholesterol concentration was inversely related to plasma cholesterol concentrations. Bone calcium, measured as percentage of dry, fat-free bone (femur), and whole-carcass ash were significantly less in pigs fed SPI-based formula than in pigs fed MP-based formula. Similar growth and development were observed in pigs fed SPI-based or MP-based formulas; however, pigs fed SPI-based formulas had significantly less bone calcium.
mesh_terms: D000818:Animals; D001823:Body Composition; D001835:Body Weight; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D004044:Dietary Proteins / Q000008:administration & dosage; D007225:Infant Food / Q000009:adverse effects*; D008099:Liver / Q000378:metabolism; D008894:Milk Proteins / Q000008:administration & dosage; D010940:Plant Proteins / Q000008:administration & dosage; D013025:Glycine max; D013552:Swine; D014886:Weaning
chemical_list: D004044:Dietary Proteins; D008894:Milk Proteins; D010940:Plant Proteins; D002784:Cholesterol; D002118:Calcium