Improvement by trapidil of cardiac function of the dog heart-lung preparation depressed by pentobarbital.
The effect of trapidil on depressed cardiac function was investigated in 5 dog heart-lung preparations. Trapidil at a dose of 60 mg improved cardiac function which had been severely depressed by 70 +/- 32 (S.D.) mg of sodium pentobarbital. This dose of trapidil, however, produced no significant increase in heart rate. The results suggest that trapidil would be useful in the treatment of heart failure.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002316:Cardiotonic Agents; D004285:Dogs; D005260:Female; D006333:Heart Failure / Q000188:drug therapy; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D010424:Pentobarbital / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D013268:Stimulation, Chemical; D014192:Trapidil / Q000494:pharmacology* / Q000627:therapeutic use
D002316:Cardiotonic Agents; D011743:Pyrimidines; D014192:Trapidil; D010424:Pentobarbital