[Stimulation of postradiation regeneration of erythropoiesis in mice with Bordetells pertussis vaccine].
Inoculation into mice of killed B. pertussis vaccine (10(10) microbial cells) one day before their sublethal irradiation (6.0 Gy) was accompanied by accelerated regeneration of erythropoiesis in the bone marrow, particularly in the spleen as was judged by the 59Fe incorporation. B. pertussis also induced an increase in endocolonization when inoculated 4-5 days after irradiation. The latter suggests a possible effect of vaccine on the hematopoietic cells, less differentiated than erythropoietin-sensitive cells (ESC), inasmuch the sensitivity of the ESC to erythropoietin commonly appeared at the later stages. When B. pertussis was inoculated into BALB/c mice one day before their infection by Rauscher's leukemia virus noticeable activation of leukemogenicity was observed. It is believed that the reason for this is the stimulation of erythroid target cells for the virus after B. pertussis vaccination. The data obtained indicate that B. pertussis vaccine activates erythropoiesis in both normal and irradiated mice.
D000818:Animals; D004920:Erythropoiesis / Q000187:drug effects* / Q000528:radiation effects; D007942:Leukemia, Experimental / Q000503:physiopathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D010567:Pertussis Vaccine / Q000008:administration & dosage*; D011833:Radiation Injuries, Experimental / Q000503:physiopathology*; D011925:Rauscher Virus
D010567:Pertussis Vaccine
Stimuliatsiia postradiatsionnoĭ regeneratsii éritropoeza u mysheĭ pod deĭstviem vaktsiny Bordetella pertussis.