Differentiation of proactivator from tissue plasminogen activator with low molecular weight in the paranasal mucous membrane.
It has been shown that large amounts of fibrinolytic enzyme are contained in tissue extracts of the paranasal mucous membrane in patients with chronic sinusitis. However, the fibrinolytic enzyme in the tissue extracts has not yet been characterized by biochemical techniques. In the present study, proactivator was differentiated from tissue plasminogen activator with low molecular weight in extracts of the paranasal mucous membrane and the existence of the proactivator was thus demonstrated in tissue extracts. By analogy with the proactivator in antrochoanal polyps, this proactivator may play an important role in the proliferation and enlargement of the paranasal mucous membrane.
D004792:Enzyme Precursors / Q000032:analysis; D006801:Humans; D009092:Mucous Membrane / Q000201:enzymology; D010256:Paranasal Sinuses / Q000201:enzymology*; D010960:Plasminogen Activators / Q000032:analysis*; D012852:Sinusitis / Q000201:enzymology*
D004792:Enzyme Precursors; C011074:plasminogen proactivator; D010960:Plasminogen Activators