Lipid composition and de novo lipid biosynthesis of human palmar fat in Dupuytren's disease.
Seventy-two surgically obtained Dupuytren's disease palmar-fat (DDPF) specimens and 18 location-matched specimens from patients not suffering from this disease (controls) were studied for their total lipid composition and de novo lipogenic activity. Incubation of "DDPF" with 1-[14C]acetate in oxygen produced [14C]palmitate and [14C]stearate in approximately equal yields as those obtained from "controls." No [14C]octanate was formed in any of the palmar-fat preparations. The lipids and fatty acid analysis revealed differences: (a) DDPF specimens were richer in free fatty acids, methyl esters of fatty acids and free-cholesterol than specimens of controls. (b) DDPF specimens contained less phospholipids. (c) DDPF specimens showed a significantly higher content of octanoate and other short-chain fatty acids than specimens of controls. The above findings are not incompatible with the results expected if some mild hypoxia occurred in DDPF; this has been suggested in the statistical correlations observed for this disease and alcoholism with liver involvement.
D000273:Adipose Tissue / Q000378:metabolism*; D002784:Cholesterol / Q000032:analysis; D002849:Chromatography, Gas; D004387:Dupuytren Contracture / Q000378:metabolism*; D005227:Fatty Acids / Q000032:analysis; D006225:Hand; D006801:Humans; D008055:Lipids / Q000032:analysis / Q000096:biosynthesis*; D010743:Phospholipids / Q000032:analysis
D005227:Fatty Acids; D008055:Lipids; D010743:Phospholipids; D002784:Cholesterol