[Effect of sulpiride on the hypothalamic monoaminergic regulation of prolactin formation and milk secretion].
Administration of sulpiride to lactating female rats reduced the content of dophamine and norepinephrine and increased the content of serotonin (5HT) in the hypothalamus. The inhibition of DA in the hypothalamus resulted in an increase of prolactin and growth hormone contents in the pituitary gland. Thus the level of prolactin is increased in the blood plasma of lactating rats. The increase of prolactin content in the pituitary gland and in blood caused an obvious stimulation of lactation.
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D005260:Female; D013006:Growth Hormone / Q000032:analysis; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D007774:Lactation / Q000187:drug effects; D008892:Milk / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000032:analysis; D011247:Pregnancy; D011388:Prolactin / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects*; D013469:Sulpiride / Q000494:pharmacology*; D013997:Time Factors
D001679:Biogenic Amines; D011941:Receptors, Adrenergic; D013469:Sulpiride; D011388:Prolactin; D013006:Growth Hormone
Vliianie sul'pirida na gipotalamicheskuiu monoaminergicheskuiu reguliatsiiu obrazovaniia prolaktina i sekretsiiu moloka.