title: Clinical and experimental keratitis due to Curvularia lunata (Wakker) Boedijn var. aeria (Batista, Lima and Vasconcelos) Ellis.
abstract: A case of mycotic keratitis due to Curvularia lunata var. aeria is reported for the first time from India. Direct microscopic examination of the corneal scrapings in KOH (50 g1(-1)), stained with lactophenol cotton blue, revealed brown septate hyphae and the cultures were found positive for fungus. It was identified as C. lunata (Wakker) Boedijn var. aeria (Batista, Lima and Vasconcelos) Ellis (IMI 253204) and its growth was better at 28 degrees C than at 37 degrees C. In vitro, the fungus was most sensitive to amphotericin B followed by miconazole nitrate, clotrimazole and triphenyltin isoselenocyanate 4-picoline which had the same activity. Lactones were least active and tolciclate and arnebins and inactive. The fungus produced experimental keratomycosis in the rabbit cornea and the infection severity as well as histopathological changes were more pronounced in rabbits that received penicillin, streptomycin and cortisone.
mesh_terms: D000328:Adult; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology; D003315:Cornea / Q000382:microbiology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007634:Keratitis / Q000209:etiology*; D008297:Male; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects / Q000302:isolation & purification* / Q000472:pathogenicity; D009181:Mycoses / Q000209:etiology*; D011817:Rabbits; D013492:Suppuration
chemical_list: D000935:Antifungal Agents