Bilateral injection of kainic acid into the rat striatum potentiates morphine, arecoline and pilocarpine but not haloperidol catalepsy.
Bilateral injections of 3 nmol of kainic acid into the rat caudate nucleus potentiated morphine, arecoline and pilocarpine catalepsy but attenuated the cataleptic response to haloperidol. These results confirm the primary importance of caudate nucleus in the appearance of neuroleptic catalepsy and suggest that this nucleus plays an important role in the inhibitory control of cataleptic responses to narcotics and cholinomimetics.
D000818:Animals; D001115:Arecoline / Q000494:pharmacology*; D002375:Catalepsy / Q000139:chemically induced*; D003342:Corpus Striatum; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D007267:Injections; D007608:Kainic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D010862:Pilocarpine / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011759:Pyrrolidines; D010862:Pilocarpine; D001115:Arecoline; D009020:Morphine; D006220:Haloperidol; D007608:Kainic Acid