Hypothesis: is viral transformation mediated by alterations in chromosomal proteins?
Efforts to clarify the mechanisms of viral carcinogenesis have been hampered, no doubt, by the lack of understanding of the complex gene-regulatory processes in the eukaryotic genome. However, numerous investigators have produced enlightening information concerning potential gene-regulatory, nuclear phosphorylation reactions. In addition, equally interesting studies involving transforming viruses have revealed that some viral products responsible for transformation have an associated protein kinase activity. These similar biochemical processes may suggest how some transforming viruses could subvert normal gene-regulatory processes.
D000818:Animals; D002472:Cell Transformation, Viral; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D014412:Tumor Virus Infections / Q000378:metabolism*
D002868:Chromosomal Proteins, Non-Histone; D006657:Histones; D011494:Protein Kinases; D012321:DNA-Directed RNA Polymerases; D004259:DNA-Directed DNA Polymerase