Effect of dietary protein restriction on the development of renal failure after subtotal nephrectomy in rats.
We have examined the effect of a low protein diet on the development of glomerular sclerosis and progressive renal failure after subtotal nephrectomies in rats. Two groups of male Sprague-Dawley rats were studied after five-sixths nephrectomy; group 1 were maintained on a normal diet (13.5 g day-1 kg-1 body weight) and group 2 were fed with a low protein diet (6 g day-1 kg-1 body weight). Rats maintained on a low protein diet survived for longer, and had significantly less glomerular sclerosis and significantly greater glomerular filtration rates when the experiment ended after 7 months. We conclude that dietary protein influences favourably the development of glomerular scarring and renal failure after subtotal nephrectomy in rats.
D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D003404:Creatinine / Q000097:blood; D004044:Dietary Proteins / Q000008:administration & dosage*; D005919:Glomerular Filtration Rate; D005923:Glomerulosclerosis, Focal Segmental / Q000473:pathology; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D009392:Nephrectomy; D011507:Proteinuria; D051381:Rats; D011919:Rats, Inbred Strains
D004044:Dietary Proteins; D003404:Creatinine