[Comparative drug therapy study with scintigraphic control research].
By means of the 99m-Tc-pertechnitate joint scintigraphy the authors try to document the effect of antirheumatic drugs in 62 patients with rheumatoid arthritis. By measuring the changes of the synovial blood circulation, conclusions are drawn as to the degree of inflammation. When trying to make a quantitative assessment of the changes of inflammation as compared with a standardised reference region, particularly on the wrist joint, it was found that the activity increased on the reference region on the forearm and that proved to be a possible source of error. The reason for this may be the early involvement of vessels in rheumatoid arthritis. For further calculations it will be necessary to set up joint and radio-nuclide-specific standards as reference points.
D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004008:Diclofenac / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010653:Phenylbutazone / Q000031:analogs & derivatives / Q000627:therapeutic use; D011877:Radionuclide Imaging; D013667:Technetium; D014046:Tolmetin / Q000627:therapeutic use; D014955:Wrist Joint / Q000098:blood supply / Q000000981:diagnostic imaging
D004008:Diclofenac; C100279:pyrazinobutazone; D013667:Technetium; D014046:Tolmetin; D010653:Phenylbutazone
Vergleichende Arzneimittelstudie mit szintigraphischen Kontrolluntersuchungen.