Stereospecificity of allergic contact dermatitis (ACD) to enantiomers. Part III. experimentally induced ACD to a natural sesquiterpene dialdehyde, polygodial in guinea pigs.
Guinea pigs were sensitized to polygodial 1, a natural sesquiterpene dialdehyde, using intradermal injections in Freund's complete adjuvant. Cross-reactions with a (+/-)-mixture of warburganal and (-)-warburganal 2 (a natural hydroxylated derivative of polygodial) showed a high specificity of the allergic response since the (-)-pseudoenantiomer (having the same configuration as the primary sensitizer) gave a stronger skin reaction than the racemic mixture.
D000485:Allergens / Q000633:toxicity*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003429:Cross Reactions; D003876:Dermatitis, Atopic / Q000139:chemically induced* / Q000276:immunology; D003877:Dermatitis, Contact / Q000276:immunology*; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000175:diagnosis; D007428:Intradermal Tests; D010936:Plant Extracts / Q000633:toxicity*; D010946:Plants, Medicinal; D012717:Sesquiterpenes / Q000633:toxicity*
D000485:Allergens; D010936:Plant Extracts; D012717:Sesquiterpenes; C037080:warburganal; C034380:polygodial