title: Double minutes and other chromosomal aberrations in two malignant cell lines of the German cockroach Blattella germanica.
abstract: Structural anomalies of mitotic chromosomes from two tumorigenic cell lines of the German cockroach (Blattella germanica) is described. Aberrations, such as unpairable marker chromosomes, double minutes, di- and tricentrics, ring chromosomes, tri- and quadriradials, and chromosome and chromatid gaps and breaks, were observed in varying proportions. This study reports that the double minute chromosomes (DMs) are associated with insect tumor cells, similar to the findings in both murine and human tumor cells.
mesh_terms: D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D003058:Cockroaches / Q000235:genetics*; D007621:Karyotyping; D008677:Metaphase; D009369:Neoplasms / Q000235:genetics*