Bu-2470, a new peptide antibiotic complex. I. Production, isolation and properties of Bu-2470 A, B1 and B2.
A strain of Bacillus circulans produced a complex of basic peptide antibiotics designated Bu-2470, which was found to contain four active components, A, B1, B2a and B2b. Bu-2470 A specifically inhibited various Pseudomonas species including P. aeruginosa, P. maltophilia and P. putida, but otherwise its antibacterial spectrum was limited to certain Gram-negative organisms. Bu-2470 B1 and B2 (B2a + B2b) showed broad antibiotic activity against Gram-positive and Gram-negative bacteria including Pseudomonas species. The physicochemical and biological properties of Bu-2470 B1 and B2 are very similar to those of the octapeptin group of antibiotics.
D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D001407:Bacillus / Q000254:growth & development*; D001419:Bacteria / Q000187:drug effects; D002854:Chromatography, Paper / Q000379:methods; D002855:Chromatography, Thin Layer / Q000379:methods; D055666:Lipopeptides; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009842:Oligopeptides / Q000302:isolation & purification / Q000633:toxicity; D010455:Peptides; D010456:Peptides, Cyclic / Q000302:isolation & purification / Q000633:toxicity; D011549:Pseudomonas / Q000187:drug effects; D013045:Species Specificity
D000900:Anti-Bacterial Agents; D055666:Lipopeptides; D009842:Oligopeptides; D010455:Peptides; D010456:Peptides, Cyclic; C013629:octapeptin antibiotics