title: Pharmacokinetic behaviour and anthelmintic efficacy of 1-n-butyl carbamoyl oxfendazole given by intramuscular injection.
abstract: Oxfendazole (OFZ) was chemically modified to 1-n-butyl carbamoyl OFZ (C4-OFZ) in an attempt to improve the solubility of OFZ and enable it to be administered by injection. After intramuscular injection to sheep and cattle, C4-OFZ was metabolised to OFZ which resulted in higher plasma OFZ concentrations that persisted for a considerably longer period than those observed following administration of OFZ orally. The anthelmintic efficacy of injected C4-OFZ was tested, in sheep, against strains of Trichostrongylus colubriformis, Haemonchus contortus and Ostertagia circumcincta, which were highly resistant to benzimidazoles. In all cases, the C4-OFZ treatment showed a significant improvement in efficacy over the conventional oral OFZ drench.
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D001562:Benzimidazoles / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000378:metabolism; D006188:Haemonchiasis / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary; D006189:Haemonchus / Q000187:drug effects; D007273:Injections, Intramuscular / Q000662:veterinary; D007700:Kinetics; D010029:Ostertagiasis / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000378:metabolism; D014251:Trichostrongyloidea / Q000187:drug effects*; D014253:Trichostrongylosis / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; C038355:1-n-butylcarbamoyl oxfendazole