Solid dispersions of testosterone with reduced presystemic inactivation.
Dissolution rates of solid dispersions of testosterone in various lipids or polyethylene glycol 6000 with and without surfactants were determined. In a limited study, selected dispersions were evaluated for oral absorption efficiency in a 32-year-old male. Significant reductions in urinary testosterone metabolites to testosterone ratios were observed with a 1:4 weight ratio of testosterone-polyethylene glycol 6000 and a 1:4:0.25 weight ratio of testosterone-cholesteryl stearate-sorbitan monolaurate.
D000328:Adult; D001711:Biotransformation; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D012995:Solubility; D013535:Suspensions; D013739:Testosterone / Q000008:administration & dosage* / Q000378:metabolism
D013535:Suspensions; D013739:Testosterone