title: Tioconazole, a new imidazole-antifungal agent for the treatment of dermatomycoses. Antifungal and pharmacologic properties.
abstract: Tioconazole is a new imidazole antifungal agent with broad-spectrum activity. Its in vitro activity against common dermal pathogens is generally better than miconazole by a factor of 2-8. This activity is paralleled by good topical efficacy in a guinea pig dermatomycosis model. Pharmacokinetic studies in animals have demonstrated minimal systemic exposure following dermal application. Acute general pharmacology studies have shown that the compound is well tolerated in animals and unlikely to produce side-effects in man.
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000378:metabolism / Q000627:therapeutic use*; D055598:Chemical Phenomena; D002621:Chemistry; D003881:Dermatomycoses / Q000188:drug therapy*; D004195:Disease Models, Animal; D006168:Guinea Pigs; D007093:Imidazoles / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D007700:Kinetics; D008825:Miconazole / Q000627:therapeutic use; D011817:Rabbits; D051381:Rats
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D008825:Miconazole; C020527:tioconazole