title: [Chromosome instability in 101/H and C57BL/6 strain mice during aging].
abstract: Frequencies of chromosomal aberrations have been shown to increase with the age in the liver cells of 101/H mice. The rate of accumulation is much higher in 101/H than in C54BL/6 mice. The frequencies of mitomycin C-induced chromosomal aberrations in bone marrow cells increased with the age in 101/H mice, but not in C57BL/6. Possible relationships between repair defects and instability of chromosomes in the aged 101/H mice are discussed.
mesh_terms: D000375:Aging / Q000187:drug effects; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D002251:Carbon Tetrachloride / Q000494:pharmacology; D002869:Chromosome Aberrations; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D008815:Mice, Inbred Strains / Q000235:genetics*; D008937:Mitomycins / Q000494:pharmacology
chemical_list: D008937:Mitomycins; D002251:Carbon Tetrachloride
vernacular_title: Nestabil'nost' khromosom u mysheĭ liniĭ 101/H i C57BL/6 pri starenii.