[Malignant hyperthermia. III. Progress report on serum CK activity, questionable screening test, effect of dantrolene in family members with a hereditary disposition].
18 members of a MH prone family have been studied to determine the value of various clinical methods which might be helpful in detecting the disposition. Tests included serum levels of CK over a period of 3 years, and of potassium, the influences of muscle provocation and pretreatment with dantrolene, concentration of cholesterol in erythrocytes and cholinesterase (activity and genotype). The results show relative constant measurements of the enzyme; there was, however, no evidence of any other reliable method in assessing the disposition.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002784:Cholesterol / Q000097:blood; D002802:Cholinesterases / Q000097:blood; D003402:Creatine Kinase / Q000097:blood*; D003620:Dantrolene / Q000627:therapeutic use; D004910:Erythrocyte Membrane / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000097:blood / Q000188:drug therapy / Q000235:genetics*; D008875:Middle Aged; D010375:Pedigree; D011188:Potassium / Q000097:blood
D002784:Cholesterol; D003402:Creatine Kinase; D002802:Cholinesterases; D003620:Dantrolene; D011188:Potassium
Maligne Hyperthermie. III. Verlaufsbeobachtung der Serum-CK-Aktivität, fragliche Suchtests, Dantroleneffekte bei Mitgliedern einer belasteten Familie.