title: Macrophage-mediated damage to filarial worms (Dipetalonema setariosum) in vivo.
abstract: An adult female Dipetalonema setariosum (Mönnig 1926) recovered from the pleural cavity of Meriones libycus and bearing an adherent cell mass examined by means of electron microscopy. The host reaction consisted exclusively of macrophages and was associated with disruption of the cuticular membrane and invasion of the cuticle itself. There was no evidence of prior activity by other cell types. Initiation of damage appeared to be associated with the release of lysosomal enzymes by the macrophages. Within the reaction a localized breaching of the cuticle had occurred and cells had penetrated the internal tissues of the worm. It is suggested that macrophages may play a role in the elimination of effect worms from an established population.
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000648:ultrastructure; D004153:Dipetalonema / Q000276:immunology* / Q000648:ultrastructure; D004154:Dipetalonema Infections / Q000276:immunology*; D005260:Female; D005368:Filariasis / Q000276:immunology*; D005849:Gerbillinae; D008264:Macrophages / Q000276:immunology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009940:Organoids / Q000648:ultrastructure; D010587:Phagocytosis