Arecoline induced nicotinic and muscarinic stimulation of the superior cervical ganglion of cat.
Arecoline (10-500 micrograms) stimulated the superior cervical ganglion (s.c.g.) of cat following intra-arterial injection into the ganglion. The ganglion stimulating effect of arecoline was weaker than that of dimethylphenylpiperizinium (DMPP) but stronger than that of pilocarpine. Similarly, the time course of response to arecoline was slower than that of DMPP but faster than that of pilocarpine. The gangliomimetic effects of arecoline, nicotine and DMPP are prevented by hexamethonium, tetraethylammonium and high doses of nicotine and arecoline. Eserine potentiated the response to arecoline but not that to DMPP and nicotine. Response to submaximal preganglionic stimulation and KCl were potentiated by arecoline and pilocarpine but not by DMPP and nicotine. The responses to arecoline and pilocarpine were also prevented by atropine which did not alter the responses to DMPP and nicotine. It is suggested that arecoline stimulated the muscarinic as well as nicotinic receptors in the s.c.g. of cat and that acetylcholine is likely to be involved partially in the gangliomimetic effects of arecoline.
D000818:Animals; D001115:Arecoline / Q000494:pharmacology*; D002415:Cats; D004246:Dimethylphenylpiperazinium Iodide / Q000494:pharmacology; D004357:Drug Synergism; D005260:Female; D005728:Ganglia, Sympathetic / Q000502:physiology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009538:Nicotine / Q000494:pharmacology; D009541:Nictitating Membrane / Q000502:physiology; D010830:Physostigmine / Q000494:pharmacology; D010862:Pilocarpine / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011976:Receptors, Muscarinic / Q000187:drug effects*; D011978:Receptors, Nicotinic / Q000187:drug effects*
D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D010862:Pilocarpine; D001115:Arecoline; D004246:Dimethylphenylpiperazinium Iodide; D009538:Nicotine; D010830:Physostigmine