Tumorigenic action of repeated subcutaneous administration of N-methyl-N-formylhydrazine in mice.
N-Methyl-N-formylhydrazine (MFH), an ingredient of the edible false morel mushroom, was administered to Swiss mice as 40 weekly subcutaneous injections at 20 micrograms/g body weight for females and 10 micrograms/g body weight for males. The treatments gave rise to statistically significant incidences of lung tumors: 56% in females and 40% in males. The administration of the chemical resulted in no detectable carcinogenic effect in other organs. The findings are discussed in light of the results from earlier studies with this compound.
D000818:Animals; D005260:Female; D007279:Injections, Subcutaneous; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D008763:Methylhydrazines / Q000008:administration & dosage*; D051379:Mice; D008815:Mice, Inbred Strains; D009002:Monomethylhydrazine / Q000008:administration & dosage* / Q000031:analogs & derivatives; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D013997:Time Factors
D008763:Methylhydrazines; C016577:N-methyl-N-formylhydrazine; D009002:Monomethylhydrazine