title: Effects of metoclopramide on plasma corticosteroid levels in sheep.
abstract: This study investigated the role of dopaminergic mechanisms in modulation of corticosteroid secretion in sheep. Administration of the dopamine antagonist metoclopramide (200 micrograms/kg iv) in six mature sheep resulted in rapid and parallel rises in plasma cortisol, corticosterone, 18-hydroxycorticosterone, and aldosterone. Treatment of the sheep with 4 mg dexamethasone im every 6 h for 4 days abolished the response of all four corticosteroids to metoclopramide in the six sheep. These observations suggest that metoclopramide may stimulate corticosteroid secretion in sheep via nonspecific stressor effects.
mesh_terms: D015069:18-Hydroxycorticosterone / Q000097:blood; D000305:Adrenal Cortex Hormones / Q000097:blood*; D000450:Aldosterone / Q000097:blood; D000818:Animals; D003345:Corticosterone / Q000097:blood; D006854:Hydrocortisone / Q000097:blood; D007700:Kinetics; D008787:Metoclopramide / Q000494:pharmacology*; D012756:Sheep
chemical_list: D000305:Adrenal Cortex Hormones; D000450:Aldosterone; D015069:18-Hydroxycorticosterone; D008787:Metoclopramide; D003345:Corticosterone; D006854:Hydrocortisone