[Iproniazid-induced hepatitis. The diagnostic value of a new antimitochondrial antibody anti-M6].
The authors report the observations of four patients with iproniazid hepatitis. Three of these patients died. An antimitochondrial antibody was found in the 4 patients at a high titer. This antibody differed from the antimitochondrial antibodies which have been described previously (anti-M1, anti-M5). This new antibody was called anti-M6. The evolution of the anti-M6 titer has been studied in the patient who survived. This titer progressively decreased; the antibody was no longer detectable 6 months after the withdrawal of iproniazid. Anti-M6 has not been found in other hepatic diseases. It was not detected in 15 patients receiving iproniazid without hepatitis or in 6 patients receiving isoniazid. Anti-M6 appears as a useful serologic marker for the diagnosis of iproniazid hepatitis.
D000328:Adult; D000906:Antibodies / Q000032:analysis*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007490:Iproniazid / Q000009:adverse effects*; D007565:Jaundice / Q000139:chemically induced / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000276:immunology*
D000906:Antibodies; D007490:Iproniazid
Hépatite à l'iproniazide. Intérêt diagnostique d'un nouvel anticorps antimitochondrial, l'anti-M6.