[Absence of a gene dose effect for collagen type I and III in fibroblasts with trisomy of chromosome 7 from a spontaneously aborted human fetus].
Collagen production was studied in human embryonal fibroblasts. Synthesis of collagen in the cells with trisomy 7 was decreased 2-fold as compared with diploid cells in spite of 50% increase of the collagen genes localized on the chromosome 7. Diploid and aneuploid cells synthesized collagens of the I and III types at similar weight ratios. At the same time, an increase in synthesis of type I collagen trimer was found in culture of cells with anomalous caryotype. A decrease of collagen production in cells with anomalous caryotype appears to be one of the reasons responsible for spontaneous abortion.
D002478:Cells, Cultured; D002906:Chromosomes, Human, 6-12 and X; D003094:Collagen / Q000235:genetics*; D004171:Diploidy; D004622:Embryo, Mammalian / Q000502:physiology*; D005260:Female; D005347:Fibroblasts / Q000502:physiology; D005796:Genes; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D014314:Trisomy
D003094:Collagen
Otsutstvie éffekta dozy gena dlia kollagena tipa I i tipa III v fibroblastnykh kletkakh s trisomieĭ po khromosome 7, poluchennykh iz spontannogo abortusa cheloveka.