Interactions of ozone and antineoplastic drugs on rat lung fibroblasts and Walker rat carcinoma cells.
Cultured rat lung fibroblasts (F-cells) and Walker rat carcinoma cells (WRC-cells) labeled with 51Cr were exposed to the following antitumor drugs alone or with O3: carmustine (BCNU), doxorubicin (Dox), cisplatin (CPt), mitomycin C (Mit C) or vitamin K3 (Vit K). Release of 51Cr (cell injury) was greater for F-cells than WRC-cells with any single treatment. Pretreatment with any drug (400 microM), except for Vit K with WRC-cells, did not significantly increase O3-induced loss of 51Cr. Co-exposure of F-cells to drugs and O3 resulted in a marked potentiation of O3-induced injury with Vit K, and an inhibition with Dox.
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002279:Carcinoma 256, Walker / Q000188:drug therapy*; D002478:Cells, Cultured; D002860:Chromium Radioisotopes; D005347:Fibroblasts / Q000187:drug effects; D010126:Ozone / Q000633:toxicity*; D051381:Rats; D014812:Vitamin K / Q000494:pharmacology
D000970:Antineoplastic Agents; D002860:Chromium Radioisotopes; D014812:Vitamin K; D010126:Ozone