Local cerebral glucose utilization in epileptic seizures of the mutant El mouse.
The neural pathway and the focus of the epileptic seizure of mutant El mice were studied by the [14C]2-deoxyglucose technique. In the mice with full tonic-clonic seizure, the entire neocortex and hippocampus showed a remarkably increased metabolic rate. By contrast, a lower metabolic rate was evident in the thalamic nuclei, central gray, locus coeruleus and some interstitial nuclei. The epileptic focus in El mice presumably exists in the hippocampus.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002540:Cerebral Cortex / Q000378:metabolism; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism; D051379:Mice; D008817:Mice, Mutant Strains; D009928:Organ Specificity; D012640:Seizures / Q000378:metabolism*
D002250:Carbon Radioisotopes; D003837:Deoxy Sugars; D003847:Deoxyglucose