Prostaglandin synthesis inhibitors: effect on angiotensin II- and oxytocin-induced contractions in rat uterine smooth muscle.
1 Eicosatetraynoic acid, the acetylene analogue of arachidonic acid, which inhibits both the cyclo-oxygenase and lipoxygenase pathways, reduced the contractile response of rat uterine smooth muscle to either angiotensin II or oxytocin. 2 Indomethacin, an inhibitor of cyclo-oxygenase, did not reduce the response to angiotensin II but did abolish the contractile response to low doses of oxytocin. 3 Nordihydroguaiaretic acid, a lipoxygenase inhibitor, totally abolished the uterine response to either oxytocin or angiotensin II. 4 The contractile response to carbachol, a cholinoceptor agonist, was unaffected by pretreatment with any of the cyclo-oxygenase or lipoxygenase inhibitors. 5 From these findings, it can be implied that some product of the arachidonate lipoxygenase pathway augments peptide-induced contractions of the rat uterus.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D010121:Oxytocin / Q000494:pharmacology*; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D014590:Uterine Contraction / Q000187:drug effects*
D011453:Prostaglandins; D000804:Angiotensin II; D010121:Oxytocin; D002217:Carbachol; D007213:Indomethacin