Histologic changes in previously irradiated thyroid glands.
Thyroid tissue from 90 patients with a history of therapeutic irradiation to the head and neck in childhood and adolescence was examined microscopically. In addition to the well-known observation that these individuals have an increased incidence of primary thyroid carcinoma, it was also demonstrated that they have an increased incidence of benign histologic changes. These changes represent a spectrum from nonspecific hyperplastic lesions to benign neoplasia and thyroiditis.
D000236:Adenoma / Q000453:epidemiology / Q000209:etiology; D000293:Adolescent; D002291:Carcinoma, Papillary / Q000453:epidemiology / Q000209:etiology; D002648:Child; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000209:etiology; D011832:Radiation Injuries / Q000453:epidemiology / Q000473:pathology*; D011878:Radiotherapy / Q000009:adverse effects*; D013961:Thyroid Gland / Q000473:pathology / Q000528:radiation effects*; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000209:etiology; D013966:Thyroiditis / Q000209:etiology; D013997:Time Factors