[Cooperative thermal transitions in normal and tumor cells].
It is established that chromatin denaturation in the cell composition under conditions approximating to equilibrium is a quasistatistical process. It is shown that thermal treatment of tissues in chromatin composition enables to reveal the thermostable block with the following parameters of denaturation Td = 89 degrees C, Td = 3.5 degrees C and Qd = (28 +/- 4) J/g DNA. It is discovered that thermostability of tumor chromatin increases compared with the normal one, and this value in case of leucosis fluctuates from 5 degrees C to 10 degrees C, but in the case of sarcomas and ascite hepatoma of rats and mice it fluctuates from 2 degrees to 5 degrees C.
D000818:Animals; D002468:Cell Physiological Phenomena; D002843:Chromatin / Q000502:physiology; D004247:DNA / Q000378:metabolism; D004273:DNA, Neoplasm / Q000378:metabolism; D006358:Hot Temperature; D006801:Humans; D008114:Liver Neoplasms, Experimental / Q000503:physiopathology; D051379:Mice; D009369:Neoplasms / Q000503:physiopathology*; D009691:Nucleic Acid Denaturation; D051381:Rats; D012513:Sarcoma, Experimental / Q000503:physiopathology
D002843:Chromatin; D004273:DNA, Neoplasm; D004247:DNA
Kooperativnye teplovye perekhody v normal'nykh i opukholevykh kletkakh.