Cytostatic activity in vitro of new cis-dichlorodiammineplatinum (II) analogs.
Cytostatic activity of 6 new cis-dichlorodiammineplatinum (II)--(DDP) derivatives were tested against human HeLa S3, Chang Liver and Lu-106 cell lines in vitro. The tests were performed according to the recommended international protecol for screening of synthetics in cell culture system. One of the tested compounds appeared to be more active than DDP, used as referential agent. The activity of the remained compounds was lower than DDP.
D000970:Antineoplastic Agents; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000031:analogs & derivatives / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans
D000970:Antineoplastic Agents; D002945:Cisplatin