Influence of extra-intestinal inflammation on the in vitro absorption of 14C-glucose and the effects of anti-inflammatory drugs in the jejunum of rats.
Inflammation was induced in the hind legs of rats by formalin injection and the in vitro jejunal absorption of 14C-glucose was studied. Treatment of rats with formalin caused a reduction in the in vitro absorption of glucose from the jejunum. Oral administration of oxyphenbutazone or a herbal anti-inflammatory drug (Withania somnifera) prior to formalin injection, resulted in no alteration in the jejunal absorption of glucose.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D007249:Inflammation / Q000378:metabolism*; D007408:Intestinal Absorption / Q000187:drug effects; D007583:Jejunum / Q000378:metabolism; D008297:Male; D010113:Oxyphenbutazone / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D010113:Oxyphenbutazone; D005947:Glucose