Prediction of cimetidine disposition in the aged.
The change in the elimination half-life of cimetidine as a function of age can accurately be predicted by an equation previously published. For the age-dependent change of the apparent volume of distribution a correction factor was developed based on total body fluid and body fat as a function of age. The predicted values correlate well with experimental data reported. Consequently, a computer program was developed for cimetidine dosage regimen prediction which can be used for "normal" subjects, young and geriatric patients without and with renal impairment.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000375:Aging; D002927:Cimetidine / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D006146:Guanidines / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D012737:Sex Factors
D006146:Guanidines; D002927:Cimetidine