The interaction of phospholipid membranes with poly(ethylene glycol). Vesicle aggregation and lipid exchange.
(1) The water soluble polymer, poly(ethylene glycol), causes aggregation of sonicated vesicles of dimyristoylphosphatidylcholine in a manner consistent with a steric exclusion mechanism. (2) Poly(ethylene glycol) promotes the exchange of lipids between multilamellar vesicles of dimyristoylphosphatidylcholine and dipalmitoylphosphatidylcholine when the lipids are in the liquid-crystalline state. (3) 31P-NMR studies demonstrate that the bilayer configuration of smectic mesophases of dipalmitoylphosphatidylcholine is substantially maintained in the presence of poly(ethylene glycol).
D004134:Dimyristoylphosphatidylcholine; D008081:Liposomes; D009682:Magnetic Resonance Spectroscopy; D010713:Phosphatidylcholines; D011092:Polyethylene Glycols; D011663:Pulmonary Surfactants
D008081:Liposomes; D010713:Phosphatidylcholines; D011663:Pulmonary Surfactants; D011092:Polyethylene Glycols; D004134:Dimyristoylphosphatidylcholine