Further experiences on experimental cerebral "no-reflow phenomenon".
The authors evaluate the effectiveness of combination groups of antiedema pharmacological agents on experimental transient bilateral cerebral ischemia. The results show that dexamethasone and furosemide appear to be the most useful combination group. However, the improvement of post-ischemic vascular re-perfusion is not different when these antiedema agents are employed simultaneously or when they are administrated alone. The experimental model allows the authors to evaluate various modalities of the injection of the dye and drugs. Better filling of the cerebral hemisphere in which the antiedema agents were injected through the common carotid artery is always recorded. Therefore, the authors conclude that the best way to obtain homogeneous post-ischemic vascular re-perfusion is to inject half of drugs through the left common carotid artery and half through the right common carotid artery.
D000818:Animals; D001929:Brain Edema / Q000188:drug therapy; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003907:Dexamethasone / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004928:Escin / Q000627:therapeutic use*; D005665:Furosemide / Q000627:therapeutic use*; D002546:Ischemic Attack, Transient / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains; D012503:Saponins / Q000627:therapeutic use*
D012503:Saponins; D004928:Escin; D005665:Furosemide; D003907:Dexamethasone