Synthesis of perhydro-1,4-thiazepines, of expected pharmacological activity. Part III. 4-(2-hydroxyethyl)-perhydro-1,4-thiazepine esters.
New esters, derivatives or the title aminoalcohol, were obtained by three classical methods in the reaction of 4-(2-hydroxyethyl)-perhydro-1,4-thiazepine (HEPT) with chlorides (method a), acid potassium salts (method b), and sodium HEPT salts with acid chlorides (method c). Compounds 3 and 5 have weak spasmolytic properties; 5 in a dose of approx. 50 mg/kg strongly depressed the central nervous system.
D000818:Animals; D001464:Barium / Q000494:pharmacology; D017609:Barium Compounds; D002492:Central Nervous System Depressants / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D002712:Chlorides; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D013058:Mass Spectrometry; D051379:Mice; D010208:Papaverine / Q000494:pharmacology; D010276:Parasympatholytics / Q000138:chemical synthesis*; D051381:Rats; D013841:Thiazepines / Q000138:chemical synthesis* / Q000494:pharmacology
D017609:Barium Compounds; D002492:Central Nervous System Depressants; D002712:Chlorides; D010276:Parasympatholytics; D013841:Thiazepines; C024986:barium chloride; D001464:Barium; D010208:Papaverine