[Disorders of vaginal development in the progeny of white rats exposed to x-ray irradiation].
One hundred and twenty white rat embryos 13-22-day-old have been irradiated with x-rays (the dose 250 R) on the 12th-14th day of embryogenesis. The embryos have been divided into series of sagittal, frontal, transversal sections and stained by means of general histological methods. The irradiation performed on the days mentioned does not affect formation of the paramesonephric ducts. In all the experimental animals the caudal end of the paramesonephric duct is separated from the mesonephric duct as a solid cellular cord in which the lumen appears later. In the experimental females the disturbances developed after irradiation are manifested first of all in retardation of the main stages of the organ's formation; the retardation is observed: in fusion of the paramesonephric ducts, in resorption of the medial septum between the fused ducts, in separating the sinuous part of the vagina from the urogenital sinus, in recanalization of the vaginal epithelial cord. More severe lesions are presented as agenesia of the vaginal sinuous part and as its atresia represented by a transversal septum of the organ. The disorders in the vagina development are depended on massive primary necrobiotic radial lesions of the mesenchymal cells around the epithelial anlages of the small pelvis.
D000818:Animals; D005260:Female; D005865:Gestational Age; D009095:Mullerian Ducts / Q000473:pathology / Q000528:radiation effects; D011247:Pregnancy; D051381:Rats; D014621:Vagina / Q000196:embryology / Q000473:pathology / Q000528:radiation effects*
Narusheniia razvitiia vlagalishcha u potomstva belykh krys pod vliianiem rentgenovskogo oblucheniia.