Aminocaproic acid decreases secondary hemorrhage after traumatic hyphema.
Forty-eight patients (49 eyes) had nonperforating traumatic hyphema. Twenty-eight patients (28 eyes with hyphema) received oral aminocaproic acid, an antifibrinolytic agent, in a dosage of 100 mg/kg every four hours for five days, up to a maximum daily dose of 30 g. Twenty patients (21 eyes with hyphema) received placebo in an identical regimen. One eye treated with aminocaproic acid rebled; seven eyes receiving the placebo rebled. The results of this study show a statistically significant reduction in the incidence of secondary hemorrhage in the patients receiving aminocaproic acid.
D000293:Adolescent; D000328:Adult; D000614:Aminocaproates / Q000008:administration & dosage*; D000933:Antifibrinolytic Agents / Q000008:administration & dosage*; D002648:Child; D004311:Double-Blind Method; D005131:Eye Injuries / Q000150:complications; D005260:Female; D006801:Humans; D006988:Hyphema / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D011446:Prospective Studies; D011897:Random Allocation; D012008:Recurrence; D014949:Wounds, Nonpenetrating / Q000150:complications
D000614:Aminocaproates; D000933:Antifibrinolytic Agents