title: Fractionation of cold-sterilized plasma. A new concept in production of non-infectious plasma proteins.
abstract: The hepatitis risk of protein fractions derived from pooled human plasma is eliminated by beta-propiolactone treatment and UV irradiation. The combination of this sterilization procedure with an adsorption and elution procedure leads to coagulation factor concentrates such as fibrinogen, factor VIII and factor IX concentrate and a stabilized serum preparation for intravenous use. This technology is carried out mostly at room temperature, without alcohol and minimum pollution. It seems, especially for developing countries, an attractive alternative to the widely used alcohol fractionation.
mesh_terms: D000327:Adsorption; D001798:Blood Proteins / Q000528:radiation effects*; D003080:Cold Temperature; D004355:Drug Stability; D005164:Factor IX / Q000528:radiation effects; D006505:Hepatitis / Q000517:prevention & control; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D013242:Sterilization
chemical_list: D001798:Blood Proteins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005164:Factor IX