Multiclonal origin of polyps in Gardner syndrome.
Electrophoretic analysis of glucose-6-phosphate dehydrogenase was performed on polyp tissue from three black female patients with Gardner syndrome and who are heterozygous for the A and B forms of this enzyme. Polyp tissues from the three patients displayed the AB phenotype. This finding suggests a multiclonal origin of polyps in Gardner syndrome. Studies of tumors originating from such polyps may provide information about the sequence of cellular events leading to malignant transformation.
D002999:Clone Cells / Q000473:pathology; D005260:Female; D005736:Gardner Syndrome / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D011127:Polyps / Q000201:enzymology / Q000235:genetics*; D014960:X Chromosome
D007527:Isoenzymes; D005954:Glucosephosphate Dehydrogenase