[The effect of epsilon-aminocaproic acid on the normalization of embolizing fatty matter in the rabbit lung following experimental fractures. A polarized light study].
It has been confirmed that epsilon-aminocaproic acid (EACA), an inhibitor of fibrinolysis, reduced the incidence of fat embolism in the lung of rabbits with experimental bone fractures. Microscopic specimens of lungs, examined under polarized light, demonstrated the reduced amounts of lipoid materials that were prevalently undergraded. The action of the drug is owed to the inhibition of some primary mechanisms, involved in the genesis and diffusion of post-traumatic fat embolism.
D000614:Aminocaproates / Q000494:pharmacology*; D015119:Aminocaproic Acid / Q000494:pharmacology*; D000818:Animals; D005260:Female; D050723:Fractures, Bone / Q000150:complications*; D050356:Lipid Metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D008859:Microscopy, Polarization; D011183:Postoperative Complications / Q000517:prevention & control; D011655:Pulmonary Embolism / Q000517:prevention & control*; D011817:Rabbits
D000614:Aminocaproates; D015119:Aminocaproic Acid
Influenza dell'acido epsilon-aminocaproico sull'assetto del materiale lipidico embolizzante nel polmone di coniglio dopo fratture sperimentali. Studio a luce polarizzata.