A new anti-mycotic drug tioxaprofen and its uncoupling effect on isolated mitochondria.
An oxazole compound, tioxaprofen, exerted a strong anti-mycotic activity against Trichophyton mentagrophytes and T. rubrum, which were major dermatophytes from patients. It was found that tioxaprofen was a potent uncoupling agent of mitochondrial respiration.
D000818:Animals; D000935:Antifungal Agents / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D005658:Fungi / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D008933:Mitochondrial Swelling / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*; D011422:Propionates / Q000633:toxicity*; D051381:Rats
D000935:Antifungal Agents; D011422:Propionates; C016869:tioxaprofen