Anti-A antibody transfused with non-group-specific platelets. Serological abnormalities.
In 1979 we identified six patients in blood group A who were given non-group-specific platelets and who had difficulties in pretransfusion testing because of passively acquired antibodies to their own A antigen. In all six, results of earlier pretransfusion testing were unremarkable. Postplatelet transfusion findings consisted of the following: (1) negative result of screening for unexpected antibodies, (2) positive result from direct antiglobulin (Coombs') test, (3) incompatible cross match with group A RBCs, and (4) detection of anti-A antibody in each patient's serum and eluate. No clinical evidence of hemolysis was present in any of the patients. Identification of passively acquired ABO antibodies and selection of compatible blood can be facilitated by (1) accurate review of transfusion history for administration of non-group-specific blood products, (2) testing of eluate against group A, B, and O RBCs, and (3) cross match of patient's sera against group O donor RBCs.
D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000517:prevention & control; D001787:Blood Group Incompatibility / Q000517:prevention & control; D001788:Blood Grouping and Crossmatching / Q000379:methods; D001803:Blood Transfusion; D006801:Humans; D007518:Isoantibodies / Q000302:isolation & purification*; D008297:Male; D017713:Platelet Transfusion
D000017:ABO Blood-Group System; D007518:Isoantibodies