Involvement of chromosomes 7 and 12 in large bowel cancer: trisomy 7 and 12q-.
Cytogenetic analysis of an adenocarcinoma of the large bowel with some villous features revealed consistent chromosome changes: trisomy of chromosomes No. 7, 12, and 20 and a deletion of part of the long arm of a chromosome No. 12. Examination of the chromosome findings in previously published cases of large bowel cancers and the data presented in this paper lead us to suggest that trisomy No. 7 and 12q- may be nonrandom (primary) karyotypic changes in a subgroup of large bowel cancers.
D000230:Adenocarcinoma / Q000235:genetics*; D000328:Adult; D002901:Chromosomes, Human, 13-15; D002906:Chromosomes, Human, 6-12 and X; D003110:Colonic Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D014314:Trisomy