title: [Antibacterial prevention of suppurative complications after operations on the large intestine].
abstract: The data on comparative study of complications after operations on the large intestine are presented. During the preoperative period, 62 patients of the control group were treated with phthalylsulfathiazole, nevigramon and nystatin. Thirty-nine patients of the test group were treated with metronidazole and kanamycin monosulfate. Kanamycin monosulfate was used 3 days before the operation in a dose of 0.5 g orally 4 times a day whereas metronidazole in a dose of 0.5 g 3 times a day. The last doses of the drugs were administered 4-5 hours before the operation. After the operations the patients were treated with kanamycin sulfate for 3-5 days in a daily dose of 2 g intramuscularly. The number of the postoperative suppurative complications decreased from 22 to 5 per cent. No lethal outcomes were registered in the test group. The number of lethal outcomes in the control group amounted to 8 per cent.
mesh_terms: D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006801:Humans; D007420:Intestine, Large / Q000382:microbiology / Q000601:surgery*; D007612:Kanamycin / Q000008:administration & dosage*; D008795:Metronidazole / Q000008:administration & dosage*; D010347:Patient Care Planning; D011292:Premedication; D011300:Preoperative Care / Q000379:methods; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D008795:Metronidazole; D007612:Kanamycin
vernacular_title: Antibakterial'naia profilaktika gnoĭnykh oslozhneniĭ posle operatsiĭ na tolstom kishechnike.