Demonstration of heterophile antibody in chicken antiserum against Marek's disease tumor-derived cell line, MSB-1.
Sheep red blood cells (SRBC) were agglutinated by all six chicken anti-MSB-1 sera examined, but not by sera of thirty specific pathogen-free chickens. The SRBC-agglutination titer was greatly reduced by absorption with SRBC, bovine red blood cells (BRBC) or guinea-pig kidney cells (GPKC). The dissociation of heterophile antibody and antibody to so-called Marek's disease tumor-associated surface antigen (MATSA) is discussed.
D000818:Animals; D000910:Antibodies, Heterophile / Q000032:analysis*; D000912:Antibodies, Neoplasm / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology; D002460:Cell Line; D002645:Chickens / Q000276:immunology*; D006386:Hemagglutination Tests; D008380:Marek Disease / Q000276:immunology*
D000910:Antibodies, Heterophile; D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D000954:Antigens, Surface