title: Peripheral postcapillary venous pressure: a new, more sensitive monitor of effective blood volume during hemorrhagic shock and resuscitation.
abstract: Peripheral postcapillary venous pressure (PCVP) and mixed venous oxygen saturation (SvO2 or PASO2) have been shown to be sensitive indicators of volume status and appear to reflect the adequacy of peripheral perfusion during controlled bleeding. This study demonstrates that in an open-chest dog model with controlled venous return, PCVP is closely and linearly (r2 = 0.6) correlated with cardiac output (CO). Furthermore, oxygen saturation as measured in the central venous system (CVSO2) and peripheral vein PVSO2) were found to be closely and linearly related to PASO2 (r = 0.72 to 0.99 and 0.91 to 0.98, respectively). Thus PCVP, CVSO2, and PVSO2 represent easily and safely obtainable parameters that closely reflect major physiologic variables. During resuscitation after controlled hemorrhage, the PCVP and PVSO2 accurately reflected the restoration of blood volume and were as good as CO and central saturations. Central venous and pulmonary wedge pressures both poorly reflected the return to full volume repletion (P less than 0.01). Thus, PCVP and PVSO2 seem to be reliable indices of volume status and perfusion and do not require invasive, central monitoring.
mesh_terms: D000818:Animals; D001775:Blood Circulation; D001811:Blood Volume Determination; D002248:Carbon Monoxide / Q000097:blood; D002302:Cardiac Output; D002496:Central Venous Pressure; D004285:Dogs; D008954:Models, Biological; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000097:blood; D011669:Pulmonary Wedge Pressure; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000503:physiopathology* / Q000628:therapy; D013997:Time Factors; D014690:Venous Pressure
chemical_list: D002248:Carbon Monoxide; D010100:Oxygen