[Neuropharmacological properties of piracetam derivatives].
Piracetam and its 8 derivatives were studied in experiments on mice and rats with the use of standard neurotropic tests and nootropic activity tools. The electrophysiological index of GABA-ergic inhibition (the recovery cycle of cortical evoked potentials) was also investigated. It was shown that piracetam derivatives as well as piracetam itself have a pronounced antihypoxic activity and prevent the amnestic effect of electroshock in experimental passive avoidance. Most of them were inactive according to the standard neurotropic test. Piracetam derivatives with a hydrazide grouping in the side chain combine nootropic activity and a specific stimulant effect, while the derivatives possessing a phenyl ring combine nootropic and depressant activity.
D000648:Amnesia, Retrograde / Q000188:drug therapy; D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004569:Electroencephalography; D004597:Electroshock; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy; D008297:Male; D051379:Mice; D010889:Piracetam / Q000031:analogs & derivatives / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D013003:Somatosensory Cortex / Q000187:drug effects; D013329:Structure-Activity Relationship
D011760:Pyrrolidinones; D010889:Piracetam
Neĭrofarmakologicheskie svoĭstva proizvodnykh piratsetama.