The effect of antioxidants on the photolysis of aqueous sulfacetamide and sulfanilamide solutions.
Aqueous sulfacetamide and sulfanilamide solutions were photolyzed at pH 1-13 and in the presence of various antioxidants and a chelating agent (pH 7.0). The rate constants for the photodegradation of sulfacetamide and sulfanilamide were determined. Sodium metabisulfite and thiourea were the best antioxidants for the photostabilization of sulfacetamide and sulfanilamide solutions respectively. Sodium edetate is also an effective stabilizer in sulfacetamide solutions. The efficiency of the antioxidants on the basis of product distribution and the kinetic results is discussed.
D000975:Antioxidants; D002626:Chemistry, Pharmaceutical; D002855:Chromatography, Thin Layer; D004355:Drug Stability; D008027:Light; D010782:Photolysis; D012996:Solutions; D013409:Sulfacetamide / Q000528:radiation effects*; D000077145:Sulfanilamide; D013424:Sulfanilamides / Q000528:radiation effects*
D000975:Antioxidants; D012996:Solutions; D013424:Sulfanilamides; D000077145:Sulfanilamide; D013409:Sulfacetamide