The decrease of the non secretory phospholipase A in rat pancreas during a chronic alcohol intoxication.
It is known that ethanol induces morphological lesions in the exocrine pancreas of man and of experimental animals. We showed recently that ethanol is metabolized by the rat pancreas. It has also been demonstrated that ethanol acts on the lipid metabolism of the pancreas by stimulating the lipid biosynthesis and by inhibiting fatty acids oxidation. We recently characterised a non secretory phospholipase A in the rat pancreas, probably involved in the intracellular phospholipid turnover. The actions of chronic alcoholic intoxication on the level of this enzyme is investigated in this paper. The ethanol intoxication was prolonged for two years and resulted in a progressive decrease in the level of the pancreatic non secretory phospholipase (p less than 0.01). This result confirms the chronic metabolic modifications induced by alcohol on the pancreas and emphasizes its metabolic participation in chronic alcoholic pancreatitis.
D000437:Alcoholism / Q000201:enzymology*; D000818:Animals; D006801:Humans; D008297:Male; D010179:Pancreas / Q000201:enzymology*; D010740:Phospholipases / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D010740:Phospholipases; D010741:Phospholipases A