Interstrand DNA crosslinks due to AP (apurinic/apyrimidinic) sites.
Storage of a solution of DNA containing apurinic sites, even at 4 degrees C leads to the appearance of interstrand crosslinks. Possible biological consequences of these crosslinks, when they appear in cell DNA, are briefly discussed. Formation of interstrand crosslinks in DNA containing tritium-labelled thymine and kept in an aqueous solution might be due, at least partly, to the loss of bases by the autoirradiated DNA.
D001080:Apurinic Acid; D055598:Chemical Phenomena; D002621:Chemistry; D004279:DNA, Viral; D009691:Nucleic Acid Denaturation; D011119:Polynucleotides; D013604:T-Phages; D014316:Tritium
D004279:DNA, Viral; D011119:Polynucleotides; C001790:apyrimidinic acid; D014316:Tritium; D001080:Apurinic Acid