An N-shaped current-voltage relationship in rat sympathetic neurones.
Neurones in the rat isolated superior cervical ganglion were voltage clamped using 2 independent microelectrodes. From a holding potential of -40mV, depolarizing voltage commands to potentials more positive than -20mV elicited outward currents. The current-voltage relationship displayed an N-characteristic with a minimum at +80 to +100mV. Replacement of the external Ca++ ions with Mn++ reversibly abolished a part of the total outward current. The results indicate that rat sympathetic neurones exhibit two potassium currents, a delayed rectifier current and a Ca++-dependent potassium current.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D004594:Electrophysiology; D005728:Ganglia, Sympathetic / Q000502:physiology*; D007700:Kinetics; D008345:Manganese / Q000494:pharmacology; D008564:Membrane Potentials; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats
D008345:Manganese; D002118:Calcium