title: [Carcinogenicity test in long-term bioassay of Fermosin-yeast grown on petroleum hydrocarbons].
abstract: To test "fermosinR'-yeast grown on petroleum hydrocarbons for carcinogenic potency the product was fed chronically at a dietary level of 15% to male and female rats (Wistar). Animals of the control group received the Institute's stock diet, similar to the yeast diet but without "fermosinR'. Feeding of "fermosinR'-diet did not affect the incidence nor the latency period nor the type of tumors compared with the control rats. Studies in mice (XVII) included two separate experiments. In the first one the dorsal skin of the animals was painted by extracts from yeast twice weekly and treated with the co-carcinogenic agent croton oil once a week. In the second experiment the mice were painted by extracts from pork of animals feed with "fermosinR'. The results obtained in rats and in mice did not reveal any evidence for carcinogenic potency of "fermosinR'-yeast.
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000821:Animal Feed / Q000633:toxicity*; D000818:Animals; D002175:Candida / Q000378:metabolism; D003436:Croton Oil / Q000008:administration & dosage / Q000633:toxicity; D004347:Drug Interactions; D005260:Female; D008297:Male; D051379:Mice; D009369:Neoplasms / Q000139:chemically induced*; D010578:Petroleum; D051381:Rats; D011919:Rats, Inbred Strains; D015002:Yeast, Dried / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D010578:Petroleum; D003436:Croton Oil; C027536:fermosin
vernacular_title: Kanzerogenitäts-Test von "fermosinR'-Futterhefe, gezüchtet auf Erdölkohlenwasserstoffen, im Langzeit-Tierversuch.