CNS involvement in the antisecretory action of [Met5]enkephalinamide on the rat intestine.
The effects of the stable enkephalin, [D-Ala2, Met5]enkephalinamide (DAMA) were examined on basal and stimulated fluid accumulation in intestinal loops of anesthetized Wistar-Furth rats. DAMA (0.1-3.0 micrograms, i.c.v.) dose-dependently increased basal fluid absorption in the medial ileum and decreased jejunal and proximal ileal fluid secretion after 4 h cholera toxin (1 microgram/loop) pretreatment. The antisecretory effects of DAMA were blocked by naltrexone (1 mg/kg s.c.). Thus, the antisecretory effects of opioids may be partially mediated at CNS sites.
D000818:Animals; D001921:Brain / Q000502:physiology*; D002772:Cholera Toxin / Q000494:pharmacology; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007082:Ileum / Q000378:metabolism; D007419:Intestinal Secretions / Q000187:drug effects*; D007583:Jejunum / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D004744:Enkephalin, Methionine; C022118:enkephalinamide-Met, Ala(2)-; D002772:Cholera Toxin