Antitumor effect of a calmodulin antagonist on the growth of solid sarcoma-180.
A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), proved to have antitumor activity against solid Sarcoma-180. In particular, intraperitoneal injection of W-7 strongly inhibited the growth of solid Sarcoma-180 in mice given a daily dose, 10 mg/kg for 10 consecutive days. A chlorine deficient analogue, N-(6-aminohexyl)-1-naphthalenesulfonamide (W-5), which interacts weakly with calmodulin, had no antitumor activity against solid Sarcoma-180, in a dose similar to that of W-7. Thus, W-7, a calmodulin antagonist may inhibit the growth of solid Sarcoma-180 by modulation of the Ca2+-calmodulin-dependent processes.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002135:Calcium-Binding Proteins / Q000037:antagonists & inhibitors*; D002147:Calmodulin / Q000037:antagonists & inhibitors*; D008297:Male; D051379:Mice; D012510:Sarcoma 180 / Q000473:pathology*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000494:pharmacology*
D000970:Antineoplastic Agents; D002135:Calcium-Binding Proteins; D002147:Calmodulin; D013449:Sulfonamides; C017967:W 7