[Therapeutic effectiveness of gentamycin and rifampicin in experimental staphylococcal-Pseudomonas aeruginosa infection and their effect on immunological processes].
The survival level of the experimental animals with infection caused by Staphylococcus and Ps. aeruginosa was the highest when the animals were treated with a combination of gentamicin and rifampicin as compared to the use of every antibiotic alone. The combination had a more favourable effect on the plasmocytic reaction and production of the antibody-forming cells in the lymphoid organs which correlated with the therapeutic efficacy of the antibiotics.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005839:Gentamicins / Q000276:immunology / Q000627:therapeutic use*; D051379:Mice; D010950:Plasma Cells / Q000187:drug effects; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000276:immunology; D012293:Rifampin / Q000276:immunology / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000276:immunology; D013997:Time Factors
D005839:Gentamicins; D012293:Rifampin
Terapevticheskaia éffektivnost' gentamitsina i rifampitsina pri éksperimental'noĭ stafilosinegnoĭnoĭ infektsii i ikh vliianie na nekotorye immunlogicheskie protsessy.