[Quantitative immunohistologic and morphometric observations on jejunum biopsy specimens].
An immunofluorescent and histologic morphometric study of jejunum biopsy specimens has been performed. Following data were taken into consideration; immunoglobulin-containing cells (Ig-CC) per 0.1 mm2 mucosal stroma, absolute quantities and percentage of IgA-, IgM- and IgG-CC, interepithelial lymphocytes (Ie-L) per 1 mm length of muscularis mucosae, dimensions of villi and intervillous area. Relatively low Ig-CC values were established in some cases with chronic enterocolitis, whereas higher Ig-CC counts were found in cases with different other enteropathies, including gluten-sensitive enteropathy. Irrespective from the varying Ig-CC values, the percentage of IgA-CC was relatively constant. The percentage of IgM- and IgG-CC was subjected to significant variations. In chronic enteropathies with advanced villous atrophy and increased intervillous area increased IgM- and IgG-CC values were established. There was no significant correlation between mucosal atrophy, Ig-CC and Ie-L values, except in cases with gluten-sensitive enteropathy.
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002452:Cell Count; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis; D007410:Intestinal Diseases / Q000473:pathology; D007583:Jejunum / Q000473:pathology*; D008214:Lymphocytes; D008875:Middle Aged
D007136:Immunoglobulins
Immunhistologische und morphometrische Untersuchungen an Jejunumbiopsien.