title: The metabolism of 3-methoxyamphetamine in dog, monkey and man.
abstract: 1. The metabolism of 3-methoxyamphetamine in vivo was examined in dog, monkey and man. 2. The metabolites identified in all three species were 3-O-methyl-alpha-methyldopamine, 1-(3-methoxy-4-hydroxyphenyl)propan-2-ol, 3-hydroxyamphetamine, 1-(3-hydroxyphenyl)propan-2-one, 1-(3-hydroxyphenyl)propan-2-ol, 1-(3-methoxyphenyl)propan-2-ol and 1-(3-methoxyphenyl)propane-1,2-diol. 3. 1-Hydroxyl-1(3-hydroxyphenyl)propan-2-one was tentatively identified in the urine of all three species. 4. 4-O-Methyl-alpha-methyldopamine was also found in the urine of dog and monkey but not in human urine.
mesh_terms: D064753:Ammonium Hydroxide; D000662:Amphetamines / Q000652:urine*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D006868:Hydrolysis; D006878:Hydroxides; D007536:Isomerism; D008253:Macaca mulatta; D008297:Male; D000644:Quaternary Ammonium Compounds; D013045:Species Specificity; D014269:Trifluoroacetic Acid
chemical_list: D000662:Amphetamines; D006878:Hydroxides; D000644:Quaternary Ammonium Compounds; C029870:3-methoxyamphetamine; D064753:Ammonium Hydroxide; D014269:Trifluoroacetic Acid; C100230:4-methoxyamphetamine