Otosclerotic lesions in the inbred LP/J mouse.
Inbred LP/J mice develop abnormal bony lesions that are grossly and histologically similar to the lesions of human otosclerosis. This is the first known occurrence of spontaneous otosclerosis-like lesions in an animal. As in the human disease, these lesions impair audition by immobilizing the ossicles of the middle ear. The LP/J mouse may be an animal model for this common human disease.
D000818:Animals; D004195:Disease Models, Animal; D004432:Ear, Middle / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains / Q000502:physiology*; D010040:Otosclerosis / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D013199:Stapes / Q000473:pathology