Acinic cell carcinoma: its occurrence in the laryngotracheal junction after thyroid radiation.
An acinic cell carcinoma of the laryngotracheal junction developed in a 54-year-old woman 46 years after administration of radiation to her thyroid gland. Although salivary gland neoplasia has been associated with a history of radiation therapy during childhood, acinic cell carcinoma in such a setting is rare. In addition, she had parathyroid hyperplasia and multiple thyroid adenomas, lesions that have been associated with prior administration of radiation. A history of exposure to radiation should be sought in patients with salivary gland neoplasms of the larynx or trachea.
D002277:Carcinoma / Q000209:etiology*; D005260:Female; D006042:Goiter / Q000532:radiotherapy; D006801:Humans; D006965:Hyperplasia; D007822:Laryngeal Neoplasms / Q000209:etiology*; D007830:Larynx / Q000528:radiation effects; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D010280:Parathyroid Glands / Q000473:pathology / Q000648:ultrastructure; D011878:Radiotherapy / Q000009:adverse effects*; D013961:Thyroid Gland / Q000528:radiation effects / Q000648:ultrastructure; D013964:Thyroid Neoplasms / Q000209:etiology; D014132:Trachea / Q000528:radiation effects; D014134:Tracheal Neoplasms / Q000209:etiology*