Activation of plasminogen by tissue activator is increased specifically in the presence of certain soluble fibrin(ogen) fragments.
Tissue activator-mediated plasminogen activation is potentiated both by fibrin and by some soluble fibrin(ogen) fragments. The potentiating effect of the different fragments decreases in the order fibrin monomer greater than D-dimer greater than Y greater than D EGTA greater than Dcate greater than X. Fibrinogen and the fragments Ecate, E EGTA and E fibrin have almost no effect. The existence of a fibrin polymer is apparently not a prerequisite for this potentiating effect. The plasminogen activation by various urokinase preparations is not potentiated by fibrin and fibrin(ogen) fragments.
D005337:Fibrin / Q000494:pharmacology*; D005338:Fibrin Fibrinogen Degradation Products / Q000494:pharmacology*; D005340:Fibrinogen / Q000494:pharmacology*; D006801:Humans; D010958:Plasminogen / Q000378:metabolism*; D010960:Plasminogen Activators / Q000494:pharmacology*; D013925:Thromboplastin / Q000494:pharmacology*; D014568:Urokinase-Type Plasminogen Activator / Q000494:pharmacology
D005338:Fibrin Fibrinogen Degradation Products; C011468:fibrinmonomer; C015214:fibrinogen D fragment; C018543:fibrinogen fragment E; C030568:fibrinogen fragment X; C036129:fibrinogen fragment Y; D005337:Fibrin; D005340:Fibrinogen; D010958:Plasminogen; D013925:Thromboplastin; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator