Antibiotic A 19009. Structural investigation and synthesis.
The structure of fermentation product A 19009 was reinvestigated by 13C and 1H NMR spectroscopy and established by independent synthesis to be N2-L-alanyl-N3-fumaramoyl-L-2,3-diaminopropanoic acid (2), i.e. a structure isomeric with the originally proposed structure 1. In contrast to 1 which also was synthesized, 2 has a very low activity against Trichomonas vaginalis.
D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D004151:Dipeptides / Q000302:isolation & purification; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D010455:Peptides; D013302:Streptomyces / Q000254:growth & development
D000900:Anti-Bacterial Agents; D004151:Dipeptides; D007202:Indicators and Reagents; D010455:Peptides; C039119:antibiotic A 19009