title: Relationship between metabolism and radioprotective activity of 2-phenylthiazolidine and its m-bromo derivative.
abstract: Molecular biotransformation of 2-phenylthiazolidine (1) and its m-bromo derivative (2) in the mouse is followed by autoradiographic studies and assessed by analysis of urinary metabolites. Cysteamine (4) is one of the metabolites of compounds 1 and 2. Radioprotective activity and efficacy over a period of time of 1, 2, and 4 correlate closely with distribution and metabolism.
mesh_terms: D000818:Animals; D001547:Benzaldehydes / Q000378:metabolism; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D003543:Cysteamine / Q000378:metabolism; D051379:Mice; D011837:Radiation-Protective Agents / Q000378:metabolism*; D013844:Thiazoles / Q000378:metabolism*; D053778:Thiazolidines
chemical_list: D001547:Benzaldehydes; D011837:Radiation-Protective Agents; D013844:Thiazoles; D053778:Thiazolidines; C039144:3-bromobenzaldehyde; C039145:2-phenylthiazolidine; D003543:Cysteamine; C039146:2-(3-bromophenyl)thiazolidine; C032175:benzaldehyde