title: Complex cytogenetic findings in acute leukemia.
abstract: Although certain types of acute nonlymphocytic leukemia (ANLL) are now characterized by specific chromosome translocations, certain other cases of ANLL elude simple cytogenetic classification. We describe here a case of acute myelomonocytic leukemia with a complex and unusual karyotype picture including double minutes, three definite translocations, two other possible translocations, and additional morphologic and numerical chromosome changes. The three definite translocations were t(2;11), t(2;12), and t(5;15), fitting the criteria of major karyotype abnormalities. These complex and unusual chromosome findings may relate to the rapid course of the disease.
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D002871:Chromosome Banding; D002900:Chromosomes, Human, 1-3; D002901:Chromosomes, Human, 13-15; D002905:Chromosomes, Human, 4-5; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic