Studies on RES function in rats and mice after different doses of fluosol.
Changes in the activity of the RES were examined by: 1. the clearance of colloidal carbon in rats (expressed by the elimination constant K); 2. determination of the tolerance of endotoxin in mice and that of gram negative enterobacteria in rats (expressed in both methods by the lethality); 3. evaluation of the temporal course of weight and the amount of PFCs taken up by two chief organs of the RES--liver and spleen. The results revealed a distinct temporal action of PFCs on the function of the RES which was terminated before cellular responses ended.
D000818:Animals; D001802:Blood Substitutes / Q000633:toxicity*; D002244:Carbon / Q000378:metabolism; D004731:Endotoxins / Q000633:toxicity; D005260:Female; D005466:Fluorocarbons / Q000633:toxicity*; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012157:Mononuclear Phagocyte System / Q000187:drug effects* / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000187:drug effects
D001802:Blood Substitutes; D004731:Endotoxins; D005466:Fluorocarbons; D002244:Carbon