Increased consumption of diazepam during continuous amphetamine administration.
Previous investigations in our laboratory have demonstrated that after implantation of slow-release d-amphetamine pellets, rats with free access to water and a 10% ethanol solution selectively increase their consumption of the ethanol solution. We now report that this d-amphetamine treatment produces a similar increase in drinking of a benzodiazepine (diazepam) solution. Female albino rats were given free access to water and a 0.060 mg/ml diazepam solution and fluid intake was recorded every two days. The baseline consumption of diazepam averaged 25% of the total daily fluid intake. After d-amphetamine pellet implantation, rats increased their diazepam consumption to an average of 48% of total fluid intake, whereas rats implanted with control pellets containing vehicle only showed no change in diazepam drinking.
D000818:Animals; D003692:Delayed-Action Preparations; D003913:Dextroamphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D003975:Diazepam / Q000008:administration & dosage*; D005260:Female; D051381:Rats; D012646:Self Administration
D003692:Delayed-Action Preparations; D003975:Diazepam; D003913:Dextroamphetamine