Prolonged plasma half-life after oral isosorbide dinitrate in patients with angina pectoris.
The plasma concentration of isosorbide dinitrate (ISDN) was monitored up to 24 h after a chronic oral dose of 60 mg in six patients with coronary artery disease. A terminal half-life of 7.7 +/- 2.6 h (mean +/- s.d.) was observed. The presence of this prolonged disappearance phase provided at least a partial explanation for the observed accumulation of ISDN in plasma after chronic dosing on a six hourly regimen.
D000787:Angina Pectoris / Q000188:drug therapy*; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D007548:Isosorbide Dinitrate / Q000097:blood* / Q000627:therapeutic use; D007700:Kinetics
D007548:Isosorbide Dinitrate