Antibodies against rabbit red blood cells in murine serum and their effect on the activity of complement alternative pathway.
Antibody content against rabbit red blood cells (anti-RaRBC) in murine sera of different strains (Swiss, CBA, C57BL/6, AKR, BALB/c) and activity of complement alternative pathway (AP) were investigated. In contrast to the CBA and C57BL/6, random-bred Swiss strain and inbred BALB/c and AKR strains are good producers of these natural antibodies. There is no correlation between AP activity and anti-RaRBC content. Isolated human anti-RaRBC antibodies, IgM and IgG classes, lead to the enhancement of APhu and APmo activity, contrary to the murine anti-RaRBC which belong solely to IgM class, and do not express this capability.
D000818:Animals; D001789:Blood Group Antigens / Q000276:immunology*; D003167:Complement Activation; D003170:Complement Pathway, Alternative; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000502:physiology; D007075:Immunoglobulin M / Q000032:analysis / Q000502:physiology; D007518:Isoantibodies / Q000032:analysis* / Q000145:classification / Q000502:physiology; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008813:Mice, Inbred ICR; D011817:Rabbits / Q000097:blood*; D013045:Species Specificity
D001789:Blood Group Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007518:Isoantibodies