[Opportunities for the evaluation of the secondary reaction of antituberculosis drugs by several indicators, determined in the blood of patients with tuberculosis of the lungs].
Some bioenergetic patterns were studied in blood and blood plasma of patients with pulmonary tuberculosis as well as--in rats after long-term daily administration of rifampycin and isoniazid at therapeutic doses. A series of bioenergetic patterns, estimated simultaneously, enabled to detect the side reactions caused by chemotherapy before occurrence of clinical symptoms. Correlation was analysed between these patterns and the routine biochemical tests used for evaluation of the drug side effects. A scheme describing relationship between amino acid transamination in blood plasma and reactions of energy metabolism is presented. The scheme shows the sequence of activation of various enzymatic reactions in blood plasma after an increase in consumption of tissue energy resources in various tissues.
D000596:Amino Acids / Q000097:blood; D000995:Antitubercular Agents / Q000009:adverse effects*; D001774:Blood Chemical Analysis; D004734:Energy Metabolism / Q000187:drug effects; D006801:Humans; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000188:drug therapy*
D000596:Amino Acids; D000995:Antitubercular Agents
Vozmozhnosti otsenki pobochnogo deĭstviia protivotuberkuleznykh preparatov po nekotorym pokazateliam, opredeliaemym v krovi bol'nykh tuberkulezom legkikh.