[Myoglobin-latex test. A new rapid test for the improvement of the early diagnosis of acute myocardial infarct].
Myoglobin concentrations were determined radioimmunologically and with a semiquantitative rapid latex test in 684 serum samples. There was a good correlation of both tests. The latex test becomes positive above 90 micrograms/l, i.e. the diagnostically relevant range. Myoglobin was determined in 27 patients with acute myocardial infarction at the same time as serum values of enzymes CK, CK-MB, LDH and GOT. This was done during three days every two hours. Diagnostically useful myoglobin increases were found on average already 2.6 +/- 0.9 hours after onset of pain, i.e. 3-4 hours before the first increase of enzymes CK-MB and CK. Out of 85 patients with acute myocardial infarction already 70% had a positive myoglobin latex test at the time of admission. In contrast, only 30% had increased enzyme activities (CK and CK-MB). Non-infarct-associated increases of myoglobin in serum were seen in patients with terminal renal failure, severe shock, muscle trauma, muscle diseases, alcohol intoxication and after reanimation.
D003402:Creatine Kinase / Q000378:metabolism; D005260:Female; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007840:Latex; D007841:Latex Fixation Tests; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis*; D009211:Myoglobin / Q000097:blood*; D011863:Radioimmunoassay; D013997:Time Factors
D007527:Isoenzymes; D007840:Latex; D009211:Myoglobin; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase
Myoglobin-Latextest. Ein neuer Schnelltest zur Verbesserung der Frühdiagnostik des akuten Myokardinfarktes.