title: Maternal ethanol exposure induces transient impairment of umbilical circulation and fetal hypoxia in monkeys.
abstract: When ethanol was administered intravenously to pregnant monkeys, a transient but marked collapse of umbilical vasculature was observed uniformly within about 15 minutes. The ethanol-induced impairment of umbilical circulation produced severe hypoxia and acidosis in the fetus; recovery occurred during the succeeding hour. This striking interruption of feto-placental circulation may explain one of the mechanisms of mental retardation, a frequent manifestation in children afflicted with fetal alcohol syndrome.
mesh_terms: D000079:Acetaldehyde / Q000097:blood; D000818:Animals; D004195:Disease Models, Animal; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000209:etiology*; D005316:Fetal Distress / Q000139:chemically induced*; D008252:Macaca fascicularis; D008253:Macaca mulatta; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D014470:Umbilical Cord / Q000187:drug effects*
chemical_list: D000431:Ethanol; D000079:Acetaldehyde