Genotoxicity studies of di(2-ethylhexyl)phthalate and its metabolites in CHO cells.
The widely used plasticizer di(2-ethylhexyl)phthalate (DEHP), its hydrolysis products mono(2-ethylhexyl)phthalate (MEHP) and 2-ethylhexanol, and also phthalic acid have been tested for clastogenic activity in cultured Chinese hamster ovary (CHO) cells. Only MEHP was found to cause chromosome damage. MEHP was without effect in the SCE and HGPRT mutation test in CHO cells. The clastogenicity of MEHP suggests a role for this compound in the observed carcinogenicity of DEHP and its positive effect in the dominant lethal assay.
D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D004051:Diethylhexyl Phthalate / Q000494:pharmacology*; D005260:Female; D009152:Mutagenicity Tests; D009153:Mutagens; D010053:Ovary; D010795:Phthalic Acids / Q000494:pharmacology*; D012854:Sister Chromatid Exchange
D009153:Mutagens; D010795:Phthalic Acids; D004051:Diethylhexyl Phthalate