Resistance and susceptibility to pulmonary metastasis of Lewis lung carcinoma in different mouse strains.
The ability of the highly metastatic 3LL tumor of C57Bl/6 (H-2b) origin to form pulmonary metastases after an intramuscular transplantation was investigated in various allogeneic mouse strains. Metastatic proliferation was observed in all tested strains of B10 genetic background. In mice of A genetic background, metastases formation was reduced and a strong resistance to metastatic progression seemed to require the association of the A genetic background with the H-2f haplotype (A.CA strain). Determination of 3H-TdR uptake in the lungs of C57Bl/6 and A.CA mice bearing large local tumors confirmed these results. The development of lung tumor nodules following an intravenous injection of 3LL tumor cells was also different in these two strains. Thus, A.CA strain appears as a useful model system for studies of mechanisms involved in metastases formation.
D000818:Animals; D002455:Cell Division; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics; D008815:Mice, Inbred Strains / Q000235:genetics*; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D013045:Species Specificity