Peroxisomal palmitoyl-CoA oxidation in the Zucker rat.
The effects of 3 or 6 days of starvation on hepatic peroxisomal palmitoyl-CoA oxidation were examined in adult lean and obese Zucker rats. When expressed either per mg of DNA or per total liver, obese rats had almost 2-fold higher oxidation rates than the lean rats. Within 6 days of starvation rates fell by 50% among both phenotypes. When data were expressed per 100 g body wt., lean and obese rats had similar rates, falling from a mean of 0.57 to 0.28 mumol/min per 100 g body wt. within 6 days of starvation. Peroxisomal oxidative changes paralleled mitochondrial beta-oxidative changes.
D000214:Acyl Coenzyme A / Q000378:metabolism*; D000818:Animals; D002374:Catalase / Q000378:metabolism; D005260:Female; D008099:Liver / Q000378:metabolism*; D008297:Male; D008830:Microbodies / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D009765:Obesity / Q000378:metabolism; D009929:Organ Size; D009940:Organoids / Q000378:metabolism*; D010084:Oxidation-Reduction; D010171:Palmitoyl Coenzyme A / Q000378:metabolism*; D051381:Rats; D011924:Rats, Zucker; D013217:Starvation / Q000378:metabolism
D000214:Acyl Coenzyme A; D009243:NAD; D010171:Palmitoyl Coenzyme A; D002374:Catalase