[Circadian variation of ischaemic ST lowering in exercise ECG (author's transl)].
The circadian variation of ischaemic ST lowering was investigated in 10 patients with coronary heart disease. The placebo phase of a randomised double blind ergometry study on the extent and duration of the action of molsidomine was used for this purpose. Non-significant tendencies with minimal expression of ST lowering were seen at 11.00 a. m. There was no dependency on changes of the pressure frequency product. In one patient ischaemic reactions recognizable at other times would not have been diagnosed at 11.00 a. m. A retrospective analysis of data gives evidence for errors in evaluation of duration and extent of action of cardiac drugs caused by diurnal variation. Consideration of time of day must be included in control investigations.
D000328:Adult; D001794:Blood Pressure; D002940:Circadian Rhythm; D003327:Coronary Disease / Q000175:diagnosis / Q000188:drug therapy; D004311:Double-Blind Method; D004562:Electrocardiography; D005080:Exercise Test; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D008981:Molsidomine; D009025:Morpholines / Q000627:therapeutic use; D010919:Placebos; D013558:Sydnones / Q000627:therapeutic use
D009025:Morpholines; D010919:Placebos; D013558:Sydnones; D008981:Molsidomine
Tageszeitliche Schwankungen der ischämischen ST-Streckensenkung im Belastungselektrokardiogramm.