[Presence of anti-Yersinia pseudotuberculosis agglutinins during a flare-up of ileal Crohn's disease. Apropos of 3 cases].
Sera of 19 patients who had been admitted with an attack of Crohn's disease were tested for agglutinins against Yersinia. The localization and the extent of the disease were highly variable. Only three patients with a subacute obstruction syndrome due to ileitis had a high circulating antibody titer directed against Yersinia pseudotuberculosis type IV (greater than or equal to 1/500). Culture of the stools did not isolate any pathogenic organisms; particularly, Yersinia pseudotuberculosis failed to grow even though specific methods were used. In one case, a strain of Yersinia enterocolitica was identified which did not prove to be pathogenic. Under corticoid and antibiotic treatment, the course was favorable in every patient. Agglutinin titers progressively decreased and serology became negative within seven to ten months. A patient had a relapse of ileitis but agglutinin titers failed to rise again. In these three patients with unquestionable Crohn's disease, it may be concluded that there was serological evidence of superinfection with Yersinia pseudotuberculosis type IV. This organism might be responsible for acute ileitis mimicking an attack of Crohn's disease.
D000328:Adult; D000373:Agglutinins / Q000032:analysis*; D003424:Crohn Disease / Q000382:microbiology*; D005260:Female; D006801:Humans; D007079:Ileitis / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D012698:Serologic Tests; D015009:Yersinia Infections / Q000175:diagnosis*
D000373:Agglutinins
Présence d'agglutinines anti-"Yersinia pseudotuberculosis" lors d'une poussée de maladie de Crohn iléale. A propos de trois cas.