The effect of an alpha-ketoglutarate-pyridoxine complex on human maximal aerobic and anaerobic performance.
The administration of 30 mg/kg of body weight of an alpha-ketoglutarate-pyridoxine complex (alpha-KG compl; stoichiometric ratio alpha-KG: pyridoxine 46.35 to 53.65) to trained non-athletic individuals increases VO2 max by 6% (p less than 0.005). The kinetics of the VO2on- and off-responses at the onset and offset of a rectangular work load is not affected by the drug. Peak blood lactate concentration [Lab] following two supramaximal running work loads lasting 60 s and 132 +/- 4 s, respectively is significantly (p less than 0.05 and p less than 0.005) less after the alpha-KG compl treatment (delta Lab = -1.1 and -2.7 mmol . l-1, respectively) than in a control group. The half time (t1/2) of La disappearance from blood during recovery is unaffected by the alpha-KG compl treatment (19.7 min vs 19.5 min). The increase in VO2 max and the corresponding decrease of [Lab] are not found after separate administration of either of the components of the complex. It is concluded that alpha-KG complex stimulates aerobic metabolism, probably prompting mitochondrial reabsorption of alpha-KG, which activates the malate-oxalacetate shuttle and the generation of high energy phosphates at the substrate level.
D000328:Adult; D000332:Aerobiosis; D000693:Anaerobiosis; D006019:Glycolysis / Q000187:drug effects; D006207:Half-Life; D006801:Humans; D007656:Ketoglutaric Acids / Q000494:pharmacology*; D007700:Kinetics; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects*; D011736:Pyridoxine / Q000494:pharmacology*; D013178:Sports Medicine; D013997:Time Factors
D007656:Ketoglutaric Acids; D007773:Lactates; D019344:Lactic Acid; D011736:Pyridoxine