Positive inotropic and negative chronotropic effect of pantethine on isolated cardiac muscle of guinea-pigs.
It was demonstrated that pantethine, a component of co-enzyme A, produces positive inotropic and negative chronotropic actions in isolated cardiac muscle preparations from guinea-pigs.
D000818:Animals; D003864:Depression, Chemical; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects*; D010204:Pantetheine / Q000031:analogs & derivatives / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013438:Sulfhydryl Compounds / Q000494:pharmacology*
D013438:Sulfhydryl Compounds; D010204:Pantetheine; C005425:pantethine