Analysis of a monofluorinated analogue of amphetamine in brain tissue using gas chromatography with electron-capture detection.
1. Difficulties encountered in the analysis of the monofluorinated amphetamine, 2-amino-3-fluoro-1-phenylpropane (AFP), are discussed. 2. A novel assay procedure and its application to the analysis of AFP in the rat brain are described. The procedure involves pentafluorobenzoylation of AFP under aqueous conditions and quantitation by a gas chromatography equipped with a capillary column and an electron-capture detector.
D000662:Amphetamines / Q000032:analysis*; D000818:Animals; D001923:Brain Chemistry; D002849:Chromatography, Gas / Q000379:methods; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000662:Amphetamines; C030480:2-amino-3-fluoro-1-phenylpropane