title: Glutamic acid decarboxylase-immunoreactive neurons and horseradish peroxidase-labeled projection neurons in the ventral posterior nucleus of the cat and Galago senegalensis.
abstract: Immunocytochemical methods were used to identify neurons in the ventral posterior nucleus of the cat and Galago senegalensis that contain glutamic acid decarboxylase (GAD), the synthetic enzyme for the inhibitory neurotransmitter, GABA. In both species GAD-immunoreactive neurons make up about 30% of the total neurons in the ventral posterior nucleus and form a distinct class of small cells. After cortical injections of horseradish peroxidase (HRP), GAD-immunoreactive cells are not labeled with HRP and may, therefore, be GABAergic local circuit neurons. Comparison of the dendritic morphology of GAD-immunoreactive neurons with that of HRP-filled projection neurons reveals that the morphology of the GAD-containing neurons is distinct and, in particular, that the GAD-immunoreactive neurons display fewer primary dendrites. The relay neurons, in turn, can be divided into classes based on dendritic morphology and cell body size.
mesh_terms: D000818:Animals; D002262:Carboxy-Lyases / Q000032:analysis*; D002415:Cats / Q000378:metabolism*; D005701:Galago / Q000378:metabolism*; D005968:Glutamate Decarboxylase / Q000032:analysis* / Q000276:immunology; D006735:Horseradish Peroxidase; D007120:Immunochemistry; D009474:Neurons / Q000032:analysis / Q000276:immunology; D013787:Thalamic Nuclei / Q000166:cytology / Q000276:immunology / Q000378:metabolism*
chemical_list: D006735:Horseradish Peroxidase; D002262:Carboxy-Lyases; D005968:Glutamate Decarboxylase