A numerical method for biphasic curve fitting with a programmable calculator.
Elimination kinetics of bromsulphalein (BSP) after a single injection into the circulation of rats were examined by means of a four-compartment model. BSP plasma concentrations were measured colorimetrically. A program written for the Texas Instruments TI-59 programmable calculator is presented, which will calculate the fractional blood clearance of BSP using an iteration procedure. A simple method of fitting biphasic decay curves to experimental data is also proposed.
D000818:Animals; D003201:Computers; D007700:Kinetics; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains; D012984:Software; D013223:Statistics as Topic; D013448:Sulfobromophthalein / Q000097:blood
D013448:Sulfobromophthalein