title: gamma-Chloronorvaline, a leucine analog from Streptomyces.
abstract: gamma-Chloronorvaline (AL-719) and gamma-hydroxynorvalinelactone (AL-719Y) were isolated from the culture broth of Streptomyces griseosporeus AL-719. Physico-chemical studies led to the structure elucidation of AL-719 and 719Y, with there respective configurations of (2S, 4S) and (2S, 4R). AL-719 shows antibacterial activity on a synthetic agar, especially against Pseudomonas aeruginosa, which was reversed by L-leucine. The producing strain AL-719 was characterized.
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003470:Culture Media / Q000032:analysis; D005285:Fermentation; D007930:Leucine / Q000096:biosynthesis; D008968:Molecular Conformation; D012988:Soil Microbiology; D013302:Streptomyces / Q000302:isolation & purification / Q000378:metabolism*; D014633:Valine / Q000031:analogs & derivatives* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media; C030873:gamma-chloronorvaline; D007930:Leucine; D014633:Valine