[Expediency of using depot kallikrein in acute liver ischemia].
The experiments in 39 rabbits have shown that the ether-oxygen narcosis and laparotomy are not indifferent and affect the morpho-functional state of the liver. Ligation of the right branch of the proper hepatic artery results in necrosis of the liver, gallbladder and lethal outcome. The use of depo-callicrein in such operations stimulates the collateral bloodflow and the recovery of hemodynamics in the organ which results in the preservation of the liver structure and in a pronounced histophysiological effect shown by unchanged proteinforming, glycogenforming and metabolic functions of the liver.
D000208:Acute Disease; D000769:Anesthesia, Inhalation; D000818:Animals; D003097:Collateral Circulation / Q000187:drug effects; D003692:Delayed-Action Preparations; D004986:Ether; D006499:Hepatic Artery; D007511:Ischemia / Q000188:drug therapy* / Q000601:surgery; D007610:Kallikreins / Q000627:therapeutic use*; D007813:Laparotomy; D008026:Ligation / Q000401:mortality; D008099:Liver / Q000098:blood supply*; D011817:Rabbits; D013268:Stimulation, Chemical
D003692:Delayed-Action Preparations; D004986:Ether; D007610:Kallikreins
O tselesoobraznosti primeneniia depo-kallikreina pri ostroĭ ishemii pecheni.