Experimental data on the prevention of retrolental fibroplasia by D-penicillamine.
Superoxide dismutase activity of alveolar macrophages, lung, liver, retina and choroid has been studied in rats and rabbits exposed to oxygen at high concentration by itself and in combination with D-penicillamine. Prolonged hyperoxia caused an increase in superoxide dismutase activity while D-penicillamine was found to inhibit the inductive effect of oxygen. It is assumed that the antioxidative effect of D-penicillamine makes it unnecessary to augment the production of superoxide dismutase.
D000818:Animals; D000975:Antioxidants; D002829:Choroid / Q000201:enzymology; D006801:Humans; D007231:Infant, Newborn; D008099:Liver / Q000201:enzymology; D008168:Lung / Q000201:enzymology; D008264:Macrophages / Q000201:enzymology; D010101:Oxygen Consumption / Q000187:drug effects; D010396:Penicillamine / Q000627:therapeutic use*; D011650:Pulmonary Alveoli / Q000166:cytology; D011817:Rabbits; D051381:Rats; D012160:Retina / Q000201:enzymology; D012178:Retinopathy of Prematurity / Q000209:etiology / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D013482:Superoxide Dismutase; D010396:Penicillamine