Drug residue formation from ronidazole, a 5-nitro-imidazole. IV. The role of the microflora.
When radioactive 1-methyl-5-nitroimidazole-2-methanol carbamate, ronidazole, labeled at the 4,5-ring positions was administered orally to germ-free and conventional rats, a much larger fraction of the radioactivity was excreted in the feces of the conventional animals. Determination of the total radioactive residues present in the carcass, blood, plasma, liver, fat and kidney 5 days after dosing indicated that the carcass of the germ-free animals contained a greater quantity of residue than that of conventional rats. On the other hand, the blood of the conventional animals contained a much higher level of radioactivity than that of the germ-free animals. These results show that while the microflora influence the distribution of the drug their presence is not obligating for the formation of persistent tissue residues in rats dosed with ronidazole.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D018407:Bacterial Physiological Phenomena; D001711:Biotransformation; D002250:Carbon Radioisotopes; D002860:Chromium Radioisotopes; D005243:Feces / Q000032:analysis; D005856:Germ-Free Life; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009593:Nitroimidazoles / Q000378:metabolism*; D051381:Rats; D012385:Ronidazole / Q000097:blood / Q000378:metabolism*
D002250:Carbon Radioisotopes; D002860:Chromium Radioisotopes; D009593:Nitroimidazoles; D012385:Ronidazole