title: Synthesis and pharmacological activity of dermorphin and its N-terminal sequences.
abstract: H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2 (demorphin), and opiate-like peptide, and tri-, tetra-, penta- and hexapeptide-amide analogs, were synthesized by conventional methods in solution, to determine the minimum peptide chain-length, required for analgesic activity.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001681:Biological Assay; D006168:Guinea Pigs; D007082:Ileum / Q000502:physiology; D007202:Indicators and Reagents; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009294:Narcotics / Q000138:chemical synthesis*; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D018847:Opioid Peptides; D014649:Vas Deferens / Q000187:drug effects
chemical_list: D007202:Indicators and Reagents; D009294:Narcotics; D009842:Oligopeptides; D018847:Opioid Peptides; C030058:dermorphin