[Effects of denervation of the soleus muscle of rats].
Histological aspects and changes in wet weight were studied on rat soleus muscles after denervation by cutting the sciatic nerve. The muscles were removed after a variable period of time from the third to the fiftieth day. There was a progressive fall off in wet weight and after the third week the muscles underwent 50% atrophy. Histological changes were most striking on sarcolemmal nuclei; they became vesicular, enlarged with prominent nucleolus and there was an apparent increase in their number. The muscle fibres changed their shape, becoming rounded and there was a 50% reduction in muscle fibre diameter after 50 days. Connective tissue abnormalities were minimal after 50 days and the striations remained intact.
D000818:Animals; D005260:Female; D009121:Muscle Denervation; D009132:Muscles / Q000473:pathology*; D009133:Muscular Atrophy / Q000473:pathology; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains
Efeitos da denervação em músculo soleus de ratos.