title: On estimating the difference between two probabilities, with special reference to clinical trials.
abstract: The problem of estimating the difference between the probabilities of 'success' for two binomial experiments is considered. Confidence intervals based on large-sample theory are constructed and some of their properties are compared with those of a simple technique based on exact distributions. It is shown that the former method is superior to the latter, both theoretically and practically.
mesh_terms: D001699:Biometry; D001932:Brain Neoplasms / Q000532:radiotherapy; D002986:Clinical Trials as Topic / Q000379:methods*; D006801:Humans; D011336:Probability; D012107:Research Design