title: Interaction between phorbol esters and phospholipid in a monolayer model membrane.
abstract: The possible molecular interaction between phorbol esters and a phospholipid was examined in monolayer films at an air-water interface. The surface pressure isotherms indicated that, at close-to-physiological pressure, there existed a repulsive interaction between the phospholipid and biologically active phorbol esters, such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and phorbol 12,13-didecanoate (PDD). There was a close parallelism between the relative biological potency of different phorbol esters, as tumour promoters, and the magnitude of their repulsive interaction with the phospholipid. These findings raise the possibility that a biophysical interference of phorbol esters with the phospholipid domain of biological membranes may represent an important determinant of their biological actions.
mesh_terms: D001665:Binding Sites; D055598:Chemical Phenomena; D002621:Chemistry; D008563:Membrane Lipids; D008567:Membranes, Artificial; D010703:Phorbol Esters; D010704:Phorbols; D011663:Pulmonary Surfactants; D013816:Thermodynamics
chemical_list: D008563:Membrane Lipids; D008567:Membranes, Artificial; D010703:Phorbol Esters; D010704:Phorbols; D011663:Pulmonary Surfactants