Immunization of mice with ultraviolet-irradiated Schistosoma mansoni cercariae: a re-evaluation.
Mice immunized by percutaneous exposure to ultraviolet-irradiated Schistosoma mansoni cercariae developed levels of resistance to subsequent S. mansoni infection comparable to those induced by gamma-irradiated cercariae (50-70% reduction in adult worm burden). Cercariae treated with ultraviolet doses ranging from one to three times the minimum dose required to prevent long-term survival induced the highest levels of resistance.
D000818:Animals; D005260:Female; D005720:Gamma Rays; D007114:Immunization; D051379:Mice; D008815:Mice, Inbred Strains; D012552:Schistosomiasis / Q000276:immunology*; D014466:Ultraviolet Rays; D014613:Vaccines, Attenuated
D014613:Vaccines, Attenuated