Modulation of the immune response by plasma protease inhibitors III. Alpha 1-antichymotrypsin inhibits human natural killing and antibody-dependent cell-mediated cytotoxicity.
The effects of alpha 1-antichymotrypsin (AChy), a serum protease inhibitor, on two parameters of the cellular immune response, natural killing (NK) and antibody-dependent cell-mediated cytotoxicity (ADCC), were tested. Both NK and ADCC were inhibited by the protein in a dose-dependent fashion. Our results suggest that this protease inhibitor binds to the surface of NK and ADCC target cells and neutralizes the lytic signal passed between the effector and target.
D000328:Adult; D000917:Antibody Formation / Q000187:drug effects*; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects*; D002918:Chymotrypsin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007122:Immunoelectrophoresis; D007694:Killer Cells, Natural / Q000187:drug effects; D000514:alpha 1-Antichymotrypsin
D000514:alpha 1-Antichymotrypsin; D002918:Chymotrypsin