Effect of high dose progestin on serum lipids.
The effect of high dose medroxyprogesterone (MPA) on serum lipids was studied in 31 postmenopausal patients with endometrial cancer. After 3 months of MPA treatment, total cholesterol decreased by 18% (P less than 0.001), LDL cholesterol by 16% (P less than 0.01) and HDL cholesterol by 38% (P less than 0.001) from the respective pretreatment values; correspondingly, the ratio of HDL to total cholesterol decreased (P less than 0.001). Similar changes were found as early as 2 weeks after start of treatment. In the 15 controls receiving no progestin treatment, full dose intracavitary radiotherapy and gynecological surgery had no effect on these serum lipids.
D000368:Aged; D000924:Anticholesteremic Agents; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000037:antagonists & inhibitors / Q000097:blood; D008077:Lipoproteins, LDL / Q000037:antagonists & inhibitors / Q000097:blood; D008525:Medroxyprogesterone / Q000008:administration & dosage*; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000097:blood / Q000188:drug therapy
D000924:Anticholesteremic Agents; D000960:Hypolipidemic Agents; D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D002784:Cholesterol; D008525:Medroxyprogesterone