[Synthesis, toxicity and antitumor action of carminomycin azine (carminazine)].
Carminomycin azine designated as carminazine was prepared by condensation of carminomycin with hydrazine hydrate. It was shown in the experiments on mice that the toxicity of carminazine was 2 and 7 times lower than that of carminomycin on its intravenous and oral administration respectively. The effect of both drugs on hemopoiesis of the mice was similar. As regards the selectivity of the antitumor effect on lymphosarcoma, strain L10-1, carminazine was inferior to carminomycin.
D000818:Animals; D000903:Antibiotics, Antineoplastic; D002360:Carubicin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D003630:Daunorubicin / Q000031:analogs & derivatives*; D004353:Drug Evaluation, Preclinical; D006410:Hematopoiesis / Q000187:drug effects; D007928:Lethal Dose 50; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy
D000903:Antibiotics, Antineoplastic; C032066:carminazine; D002360:Carubicin; D003630:Daunorubicin
Sintez, toksichnost' i protivoopukholevoe deĭstvie azina karminomitsina (karminazina).