In vitro cytotoxicity to alveolar macrophages of tar from a low-Btu coal gasifier.
The cytotoxicity of fractions, subfractions, and some individual components present in tar from a low-Btu coal gasifier was determined in vitro with cultured dog alveolar macrophages. A subfraction of the tar which contained phenols and neutral nitrogen heterocycles was found to be a major contributor to the cytotoxic activity of the tar. Four compounds present in this subfraction were tested individually. Ranked from the most to the least toxic they were: 9-phenanthrol, 2-fluorenol, phenanthridone, and carbazole.
D000818:Animals; D002478:Cells, Cultured; D002850:Chromatography, Gel; D003033:Coal Tar / Q000032:analysis / Q000302:isolation & purification / Q000633:toxicity*; D004285:Dogs; D008401:Gas Chromatography-Mass Spectrometry; D008264:Macrophages / Q000187:drug effects*; D011650:Pulmonary Alveoli / Q000187:drug effects*; D013329:Structure-Activity Relationship
D003033:Coal Tar