Area postrema lesions disrupt food intake induced by cerebroventricular infusions of 5-thioglucose in the rat.
The present experiment assesses the contribution of the area postrema (AP) to glucoprivic feeding in the rat. Lateral ventricular infusions of 5-thioglucose increased pelleted food intake in sham animals but not in animals with AP lesions. Drinking in response to infusion of angiotensin II into the lateral ventricle was not reduced by AP lesions. The data suggest that the AP is part of the brainstem circuitry underlying glucoprivic feeding.
D000818:Animals; D002552:Cerebral Ventricles / Q000502:physiology*; D005247:Feeding Behavior / Q000187:drug effects*; D005947:Glucose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D007276:Injections, Intraventricular; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
C003002:5-thio-D-glucose; D005947:Glucose