Teratology study with orciprenaline sulfate in rabbits.
Orciprenaline sulfate (Alupent), a beta-adrenoceptor stimulant, was studied for adverse effects on pregnant rabbits and their fetuses. Himalayan rabbits (Kawanishi) were dosed orally at 0 (control), 5, 25 and 50 mg/kg/d from gestation day 6 through 18. 15 does were used per group. No distinct influences of orciprenaline sulfate on litter parameters and no teratogenic effect was observed including the "maximum tolerated dose" of 50 mg/kg.
D000818:Animals; D005260:Female; D005333:Fetus / Q000187:drug effects; D009921:Metaproterenol / Q000633:toxicity*; D011247:Pregnancy; D011817:Rabbits; D012098:Reproduction / Q000187:drug effects; D013723:Teratogens
D013723:Teratogens; D009921:Metaproterenol