[Systemic reactions in rats following the initiation of a local inflammatory process by subcutaneous administration of spirits of turpentine].
Local inflammation was induced in rats by single (1 x 4 ml/kg) or multiple (14 X 0.2 ml/animal) infections of turpentine. The induction of inflammatory processes in both groups resulted in anemia and granulocytosis following an initial leukopenia. Thrombopenia on the second day, followed by thrombocytosis, was also observed in both groups. Studies on blood chemistry parameters revealed a decline in serum albumin; elevation of alkaline phosphatase in serum was observed only after multiple injection of turpentine. In these animals an elevation in the weights of spleen and adrenals and a reduction in the weight of thymus were also found.
D000818:Animals; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D006454:Hemoglobins / Q000378:metabolism; D007249:Inflammation / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014425:Turpentine / Q000633:toxicity*
D006454:Hemoglobins; D014425:Turpentine
Systemische Reaktionen in Ratten nach Setzung lokal entzündlicher Prozesse durch subcutane Terpentinöl-Gaben.