Urinary MHPG and HVA excretion in boys with attention deficit disorder and hyperactivity treated with d-amphetamine.
The authors examined the excretion of 3-methoxy-4-hydroxyphenylglycol (MHPG) and homovanillic acid (HVA) in nine hyperactive and nine control boys admitted to a clinical research center. The hyperactives excreted lower 24 hr MHPG and HVA levels than controls. d-Amphetamine 0.5 mg/kg body weight daily for 2 weeks decreased MHPG and increased HVA. These data replicate the authors' previous findings on MHPG and HVA and on the effect of d-amphetamine in hyperactive children. The data suggest the involvement of norepinephrine and dopamine in the etiology of hyperactivity. It further suggests d-amphetamine may achieve its clinical effects in hyperactivity by inhibiting NE and potentiating DA activity.
D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000652:urine; D002648:Child; D003913:Dextroamphetamine / Q000627:therapeutic use*; D006018:Glycols / Q000652:urine*; D006719:Homovanillic Acid / Q000652:urine*; D006801:Humans; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D010648:Phenylacetates / Q000652:urine*
D006018:Glycols; D010648:Phenylacetates; D008734:Methoxyhydroxyphenylglycol; D003913:Dextroamphetamine; D006719:Homovanillic Acid