Time course study of the changes in blood glutathione induced by acute ethanol intoxication in the rat.
Acute ethanol treatment of rats (5 g/kg) has a biphasic effect on the glutathione content of the erythrocyte. After 3 h of intoxication there is a diminution in total GSH equivalents, followed by a recovery to basal values 6 h after treatment. The decrease of total GSH equivalents is mainly due to a diminution of the oxidized form of the tripeptide. Concomitantly a marked increase in the plasma level of glutathione was found at 3 h, followed by a diminution to values obtained at time zero.
D000818:Animals; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D000431:Ethanol / Q000633:toxicity*; D005978:Glutathione / Q000097:blood*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol; D005978:Glutathione