Degeneration of cochlear neurons after amikacin intoxication in the rat.
Intoxication with high doses of the aminoglycoside antibiotic amikacin in a supranormal sensitive period in the rat induces complete destruction of the inner and outer hair cells in the organ of Corti in all turns, whereas the supporting cells remain partially preserved in the upper turns. With increasing survival time, the number of ganglion cells in the spiral ganglion decreases progressively, reaching a minimum of about 10% surviving cells after 12 months. Both type I and type II neurons are subject to retrograde degeneration, although type-II cells degenerate more slowly than type-I cells. The presence or absence of supporting cells in the organ of Corti does not seem to influence neuronal degeneration. This retrograde degeneration is similar in all animals so far studied but its time course is different from different species. Retrograde degeneration after destruction of Corti's organ is a long-lasting process and is never completed at once. This must be taken into consideration in the treatment of total deafness with electric stimulation of surviving neurons.
D000583:Amikacin / Q000506:poisoning* / Q000633:toxicity; D000818:Animals; D003051:Cochlea / Q000187:drug effects* / Q000648:ultrastructure; D005724:Ganglia / Q000648:ultrastructure; D007612:Kanamycin / Q000031:analogs & derivatives*; D008854:Microscopy, Electron; D009475:Neurons, Afferent / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D007612:Kanamycin; D000583:Amikacin