[Carcinogenic effect of N-methyl-N-nitro-N-nitrosoguanidine on male rats of different inbred lines].
Rats reveal distinct variations in response to carcinogenic action. The highest frequency of stomach tumors (69.6%) and the shortest period of their development (54.7 weeks) were registered in noninbred rats. Multiple lesions of the gastrointestinal tract were relatively frequent, too. Augustus and Penguin rats responded with a high frequency of tumor development. However, tumors arose in them later than in noninbred rats. Wistar rats appeared to be relatively resistant to MNNG action.
D000230:Adenocarcinoma / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D005770:Gastrointestinal Neoplasms / Q000139:chemically induced*; D008297:Male; D008769:Methylnitronitrosoguanidine; D009374:Neoplasms, Experimental / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000139:chemically induced
D008769:Methylnitronitrosoguanidine
Osobennosti kantserogennogo deĭstviia N-metil-N-nitro-N-nitrozoguanidina na krys-samtsov razlichnykh inbrednykh liniĭ.