Effect of dopamine on phosphate reabsorption in isolated perfused rabbit proximal tubules.
The effect of dopamine (10(-6) M) on PO4 reabsorption was studied in isolated and perfused proximal convoluted and straight tubules of the rabbit. In convoluted tubules, fluid reabsorption (JV), PO4 lumen-to-bath (JPO4lb), and net (net JPO4) fluxes did not change during dopamine exposure. In S3 segments bathed in rabbit serum, JV diminished significantly during dopamine exposure. JPO4 decreased by 20% (p less than 0.005) and net JPO4 decreased by 27% (p less than 0.02). The effect of dopamine was reversible upon removal of the drug.
D000042:Absorption; D000818:Animals; D004298:Dopamine / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000378:metabolism*; D010477:Perfusion; D010710:Phosphates / Q000378:metabolism*; D011817:Rabbits
D010710:Phosphates; D004298:Dopamine