title: Comparative bioavailability study of theophylline tablets marketed in Australasia.
abstract: Average peak concentrations of theophylline in plasma (range, 15 mumol/L) were not significantly different when Nuelin, Brondecon and Choledyl tablets were administered to healthy subjects. The fraction of the theophylline dose absorbed from these preparations was comparable (range, 0.82 to 0.90). In contrast, the absorption of theophylline was significantly different (P < 0.001) when the times to reach peak theophylline concentration were compared. Mean peak theophylline concentrations were achieved 1.5 hours after administration of either Nuelin or Brondecon tablets and nine hours after Choledyl administration. Nuelin and Brondecon are considered to be bioequivalent. Choledyl may be used when side effects caused by rapid theophylline absorption are to be avoided.
mesh_terms: D000042:Absorption; D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy; D001682:Biological Availability; D002794:Choline / Q000031:analogs & derivatives* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D007700:Kinetics; D011897:Random Allocation; D013806:Theophylline / Q000031:analogs & derivatives* / Q000378:metabolism*; D013997:Time Factors
chemical_list: D003692:Delayed-Action Preparations; C012839:cholinophyllin; D013806:Theophylline; D002794:Choline