title: An electrocochleographic study of the effects of lignocaine on patients with tinnitus.
abstract: Twenty patients complaining of tinnitus were investigated by extra tympanic electrocochleography (ECochG). Baseline ECochG recordings were carried out, followed by sequential recording after injections first of saline, as a control, and then after lignocaine in the dosage 1.5 mg/kg body weight. Significant improvement in the tinnitus was seen in 13 patients after lignocaine compared with only 3 patients after saline. A statistically significant reduction in the amplitude of the action potential was seen after the lignocaine injection. Our results confirm the views of Melding et al. that the effect of lignocaine is on the neuronal activity of the auditory pathway.
mesh_terms: D000328:Adult; D000368:Aged; D001299:Audiometry; D001300:Audiometry, Evoked Response; D003051:Cochlea; D005260:Female; D006801:Humans; D007759:Labyrinth Diseases / Q000150:complications; D008012:Lidocaine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D014012:Tinnitus / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D008012:Lidocaine