Myoinositol decreases N-nitroso-N-methylurethane induced lung surfactant deficiency.
Administration of 7.5 mg/kg body wt. of N-nitroso-N-methylurethane subcutaneously to rabbits decreased disaturated phosphatidylcholine, phosphatidylglycerol, and increased the minimum surface tension of alveolar lavage return. As compared to rabbits treated with N-nitroso-N-methylurethane alone, myoinositol supplementation (3-7 g/kg per day) of N-nitroso-N-methylurethane treated animals largely prevented both the decrease in disaturated phosphatidylcholine, and the increase in minimum surface tension. Myoinositol may be an important nutrient following damage of alveolar epithelium.
D000818:Animals; D007294:Inositol / Q000494:pharmacology*; D008297:Male; D009605:Nitrosomethylurethane / Q000037:antagonists & inhibitors* / Q000633:toxicity; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000378:metabolism; D011663:Pulmonary Surfactants / Q000172:deficiency*; D011817:Rabbits; D013500:Surface Tension; D007507:Therapeutic Irrigation; D014520:Urethane / Q000031:analogs & derivatives*
D011663:Pulmonary Surfactants; D014520:Urethane; D007294:Inositol; D009605:Nitrosomethylurethane