title: Manifest mastoiditis in childhood: a current critical review.
abstract: We made a follow-up study on forty children from our patient material, which had been operated because of manifest mastoiditis. We could establish the following: the number of operations has been increasing in recent years while there has been a significant drop in the number of cases with a preceding phase of otitis. A very characteristic pathological alteration, viz. the proliferation of granular tissue was found during the operation indicating that a short anamnestic period is illusory since before the mastoiditis manifests itself, there has obviously been a latent, long-lasting inflammatory process which apparently goes on without symptoms. Antibiotics, their excessive and unnecessary dosage, together with viral infections reducing immunity, may play a considerable role in the occurrence of these characteristic changes.
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008417:Mastoiditis / Q000473:pathology* / Q000601:surgery; D010031:Otitis / Q000150:complications
chemical_list: D000900:Anti-Bacterial Agents