title: Adverse effects from the circadian fluctuations of carbamazepine plasma levels.
abstract: In children on carbamazepine therapy who were complaining of tiredness it was proposed that the considerable plasma drug level variation over the day could explain this side effect. In spite of a "normal" fasting level the plasma drug level 2-4 hours after drug intake was well above the upper recommended therapeutic level. It is recommended that the time of sampling should be taken into account in carbamazepine drug monitoring.
mesh_terms: D000293:Adolescent; D002220:Carbamazepine / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D002220:Carbamazepine