Unusual particles in motor neuron disease.
Regions of neurofilamentous degeneration adjacent to and contiguous with filamentous enlargements in areas of neuronal degeneration in the spinal cord were found in six cases of sporadic motor neuron disease (MND). Unusual particles, 28 nm in diameter, were found within the lesions. The lesion might possibly be significant in relation to neuronal degeneration in MND.
D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000473:pathology*; D009468:Neuromuscular Diseases / Q000473:pathology*; D013118:Spinal Cord Diseases / Q000473:pathology*