Amoxapine overdose. Seizures and fatalities.
Thirty-three amoxapine overdoses, including five fatalities, were reported to two regional poison centers over an 18-month study period. The 15.2% mortality rate stands in alarming contrast to the 0.7% death rate for all other cyclic antidepressant overdoses reported to these same two centers during the study. Seizure activity was noted in 36.4% of amoxapine overdoses, compared with 4.3% of other cyclic antidepressant poisonings. Amoxapine appears to be responsible for a disproportionate share of seizures and deaths resulting from cyclic antidepressant overdose.
D000293:Adolescent; D000328:Adult; D000657:Amoxapine / Q000097:blood / Q000378:metabolism / Q000506:poisoning*; D002490:Central Nervous System / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D003989:Dibenzoxazepines / Q000506:poisoning*; D005260:Female; D006801:Humans; D008297:Male; D012306:Risk; D012640:Seizures / Q000139:chemically induced* / Q000401:mortality; D019966:Substance-Related Disorders / Q000401:mortality; D013406:Suicide, Attempted / Q000523:psychology
D003989:Dibenzoxazepines; D000657:Amoxapine