[Identification of chlorzoxazone metabolites in human urine (author's transl)].
Besides 6-hydroxychlorzoxazon II, the main metabolite of 5-chlorobenzoxazolin-2-one (chlorzoxazone I, Paraflex) two other compounds were found to be metabolites of chlorzoxazone: 5-chloro-2,4-dihydroxyacetanilide XXII is produced from 6-hydroxychlorzoxazone II by ring cleavage and acetylation of the nitrogen. More interesting is the formation of the 6-hydroxybenzoxazolone XX. This compound is formally produced by substitution of Cl for hydrogen and hydroxylation of a neighbour ring-carbon atom.
D000107:Acetylation; D001583:Benzoxazoles / Q000652:urine*; D001711:Biotransformation; D002753:Chlorzoxazone / Q000652:urine*; D006801:Humans; D006900:Hydroxylation
D001583:Benzoxazoles; D002753:Chlorzoxazone
Identifizierung von Chlorzoxazon-Metaboliten im menschlichen Urin.