Immunological effects of 1alpha-hydroxycholecalciferol (1alpha-OH-D3) and its metabolites.
An immunosuppressive substance was detected in the serum and plasma of hemodialysis patients. There was a marked increase in its activity immediately after hemodialysis. This substance was not detected in the plasma of hemodialysis patients treated with 1alpha-hydroxycholecalciferol (1alpha-OH-D3), although its disappearance was unrelated to either the total dose or the duration of treatment with 1alpha-OH-D3. During in vitro studies, 1alpha-OH-D3 did not change the phytohemagglutinin-, staphage lysate- and concanavalin A-induced and spontaneous lymphoproliferation of peripheral blood lymphocytes (PBL) from a healthy person. Furthermore, addition of 1alpha-OH-D3 to the plasma of hemodialysis patients who had not received 1alpha-OH-D3 did not interfere with the suppressive activity. On the other hand, 1alpha,24(R)-dihydroxycholecalciferol, 1alpha,24(S)-dihydroxycholecalciferol, and 1alpha,25-dihydroxycholecalciferol, which are all metabolites of 1alpha-OH-D3, suppressed mitogen-induced lymphoproliferation of PBL from a healthy person.
D000328:Adult; D000368:Aged; D002117:Calcitriol / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D004100:Dihydroxycholecalciferols / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D007109:Immunity / Q000187:drug effects; D007166:Immunosuppressive Agents; D007674:Kidney Diseases / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D007166:Immunosuppressive Agents; C023850:1 alpha,24-dihydroxyvitamin D3; D004247:DNA; D002117:Calcitriol; C008088:alfacalcidol