Failure of single-dose lecithin to alter aspects of central cholinergic activity in Alzheimer's disease.
The effect of a single dose (15 g/70 kg) of lecithin (95% phosphatidylcholine) on several measures of central cholinergic activity (memory, cortisol, prolactin, pulse, blood pressure) was assessed in individuals with Alzheimer's disease. In contrast to the reported effects of physostigmine, a cholinesterase inhibitor, lecithin had no effect on these parameters, despite significant increases in plasma and erythrocyte choline.
D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D002794:Choline / Q000097:blood; D003704:Dementia / Q000188:drug therapy*; D004912:Erythrocytes / Q000032:analysis; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008568:Memory / Q000187:drug effects; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000008:administration & dosage* / Q000494:pharmacology; D011388:Prolactin / Q000097:blood; D011674:Pulse / Q000187:drug effects
D010713:Phosphatidylcholines; D011388:Prolactin; D002794:Choline; D006854:Hydrocortisone