title: Interactive effects of genotype and early life undernutrition on the development of behavior in rats.
abstract: Developing rats of 2 outbred stocks were either well-nourished or undernourished by underfeeding their mothers throughout pregnancy and lactation. All rats were well-fed from 25 days of age. Starting at 110 days male rats were observed first in an open field and then in a social situation; finally their motor performance was tested on a revolving drum. The social behavior test comprised pairing male rats of the same stock, 1 well-fed control with 1 previously undernourished rat. Analysis of variance of the results of the open-field and social behavior tests revealed main effects of Nutrition and of Stock for several measures of behavior in each test. There were also Nutrition X Stock interactions for 2 measures from the open field and 1 from the social situation. Motor performance was not impaired by early life undernutrition. The evidence of Nutrition X Stock interactions, together with that from analyses of the effects of nutrition performed separately for the 2 stocks, as if each stock had been investigated in a separate study, indicates that genotypic differences may be one of the reasons for the discordance often found between the conclusions of different early life malnutrition studies.
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001835:Body Weight; D001921:Brain / Q000254:growth & development; D005838:Genotype; D051379:Mice; D009748:Nutrition Disorders / Q000235:genetics / Q000523:psychology*; D051381:Rats; D011919:Rats, Inbred Strains; D012919:Social Behavior; D013045:Species Specificity