title: The need for prophylactic treatment to the central nervous system in patients with aggressive non-Hodgkin's lymphoma.
abstract: During 2 years, 6 out of 34 patients presenting with newly diagnosed non-Hodgkin's lymphoma developed central nervous system (CNS) complications. All were male and had diffuse, undifferentiated lymphomas. In all 6 patients, CNS disease developed during, or shortly after, treatment. We suggest that a group at high risk from these complications can be identified and should be considered for a trial of prophylaxis.
mesh_terms: D000328:Adult; D000368:Aged; D002493:Central Nervous System Diseases / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D008223:Lymphoma / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged