Effect of sodium cis-beta-4-methoxybenzoyl-beta-bromacrylate (Cytembena) on HeLa cell kinetics.
The treatment of HeLa cells with various concentrations of sodium beta-4-methoxybenzoyl-beta-bromacrylate (Cytembena) results in inhibition of growth and modification of cell cycle distribution. These phenomena were observed at concentrations between 7.5 x 10(-5) and 2.5 x 10(-5) M. The estimation of DNA content by flow cytometry showed an important shift in the distribution of cycling cells with a relative decrease of G0 + G1 cells and a striking accumulation of G2 + M cells. According to our experimental conditions, the blocking up in G2 + M is irreversible at 7.5 and 5 x 10(-5) M.
D000179:Acrylates / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects*; D006367:HeLa Cells / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007399:Interphase / Q000187:drug effects; D007700:Kinetics
D000179:Acrylates; C100245:bromebric acid