[Changes in the activity of oxidative enzymes in thymus cells of CBA mice during carcinogenesis induced by simian adenovirus SA7(C8)].
Microspectrophotometry was used to study the activity of oxidative enzymes in the cortical and medullar regions of the thymus, in epithelial stromal cells of CBA mice at varying time of postnatal development and during induced virus cancerogenesis. It was shown that in the thymus of control animals, the activity of NAD-, NADP-diaphorases and beta OBDH reached maximum on the 30th day of postnatal development. The animals exposed to virus manifested a distinct lowering of the activity of the enzymes even in the latent period of cancerogenesis. Variations of the activity of the test enzymes during postnatal development of control animals and at varying time of cancerogenesis appear to be related to functional potencies of the thymus.
D000256:Adenoviridae; D000261:Adenoviruses, Simian; D000818:Animals; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D006393:Hemangiopericytoma / Q000201:enzymology*; D006884:Hydroxybutyrate Dehydrogenase / Q000378:metabolism; D051379:Mice; D009252:NADPH Dehydrogenase / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000201:enzymology; D010088:Oxidoreductases / Q000378:metabolism*; D013950:Thymus Gland / Q000201:enzymology*
D010088:Oxidoreductases; D006884:Hydroxybutyrate Dehydrogenase; D009252:NADPH Dehydrogenase; D008058:Dihydrolipoamide Dehydrogenase
Izmenenie aktivnosti okislitel'nykh fermentov v kletkakh timusa mysheĭ CBA v protsesse kantserogeneza, indutsirovannogo obez'ian'im adenovirusom SA7(C8).