Influence of chronic ethanol consumption on the metabolism and carcinogenicity of tobacco-related nitrosamines.
The effect of chronic ethanol consumption by Syrian golden hamsters (SGH) on the carcinogenicity and target tissue metabolism of N-nitroso-pyrrolidine (NPYR) and N'-nitrosonornicotine (NNN) has been examined. Ethanol-consuming hamsters treated with NPYR developed more nasal cavity and tracheal tumours than controls. Ethanol consumption did not affect the carcino-genicity of NNN. When the metabolism of NPYR and NNN by isolated tracheal rings was examined, it was observed that tracheal rings isolated from ethanol-consuming SGH metabolized NPYR at a higher rate than similar preparations from control animals. In contrast, no differences in the rates of metabolism of NNN were observed.
D000437:Alcoholism / Q000150:complications* / Q000378:metabolism; D000818:Animals; D002273:Carcinogens; D006224:Cricetinae; D006801:Humans; D066298:In Vitro Techniques; D008647:Mesocricetus; D009242:N-Nitrosopyrrolidine / Q000009:adverse effects* / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines / Q000009:adverse effects* / Q000378:metabolism; D009669:Nose Neoplasms / Q000139:chemically induced*; D010947:Plants, Toxic; D014026:Nicotiana / Q000032:analysis*; D014132:Trachea / Q000378:metabolism; D014134:Tracheal Neoplasms / Q000139:chemically induced*
D002273:Carcinogens; D009602:Nitrosamines; D009242:N-Nitrosopyrrolidine; C008655:N'-nitrosonornicotine