[In vitro incorporation of radioactive sulfur into proteoglycans of cartilage. Effects of various nonsteroidal anti-inflammatory agents].
Radioactive sulphur (35SO4) is incorporated in the proteoglycans of chicken embryonic cartilage. In fact, the molecular weight of the macromolecules which bind the sulphur corresponds to monomeric proteoglycans and proteoglycan-hyaluronic acid complexes. This incorporation does not take place when the cartilage has been previously killed. The capture of 35S is stimulated by human serum, in a dose-dependent way. At doses less then, equal to and greater than the maximal plasma concentrations observed following a single oral dose (600 mg), acetyl salicylic acid and sodium salicylate inhibit the incorporation of radioactive sulphur in the cartilage. Under the same conditions, tiaprofenic acid and oxametacine have no effect on this metabolic parameter.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002356:Cartilage / Q000378:metabolism*; D002642:Chick Embryo; D003470:Culture Media; D007700:Kinetics; D011509:Proteoglycans / Q000096:biosynthesis*; D013455:Sulfur / Q000378:metabolism*; D013462:Sulfur Radioisotopes
D000893:Anti-Inflammatory Agents; D003470:Culture Media; D011509:Proteoglycans; D013462:Sulfur Radioisotopes; D013455:Sulfur
Incorporation du soufre radioactif dans les protéoglycanes du cartilage in vitro. Effets de certains anti-inflammatoires non stéroïdiens.