Effects of glucose, anoxia, and adriamycin on the chemiluminescence of Ehrlich Ascites cells.
Glucose and anoxia accelerate the photocount due to luminescence of Ehrlich Ascites cells. Adriamycin also has this effect if glucose is present. Comparison with a chemical standard combined with estimates of cellular and population transmittance yield a photon generation rate of at least 10 . s-1 . cell-1 in the presence of 10(-2) M glucose, and twice this with anoxic conditions or 10(-5) M adriamycin. Effects of adriamycin on Ehrlich Ascites cell respiration may depend on the presence of glucose.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000503:physiopathology*; D002455:Cell Division / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology*; D000860:Hypoxia / Q000503:physiopathology*; D007700:Kinetics; D049449:Luminescence; D051379:Mice
D004317:Doxorubicin; D005947:Glucose