Developmental changes in rabbit pulmonary cytochrome P-450 subpopulations.
Of the two characterized cytochrome P-450 subpopulations present in adult lung microsomes, only one (P-450II) appears to be present in the neonate. Both this subpopulation and a second subpopulation (P-450I) gradually increase over a period of several months, and account for most of the increase in lung cytochrome P-450 concentration during maturation. A third fraction of the cytochrome P-450, which is incapable of forming metabolic-intermediate complexes remains constant in concentration during maturation, thus decreasing from 60% of the total in the neonate to 20% in the adult. Metyrapone binding to lung cytochrome P-450 which increases during development does not correlate quantitatively with either of the two characterized subpopulations.
D000375:Aging; D000662:Amphetamines / Q000378:metabolism; D000818:Animals; D001589:Benzphetamine / Q000031:analogs & derivatives / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005260:Female; D008168:Lung / Q000254:growth & development* / Q000378:metabolism; D008297:Male; D008797:Metyrapone / Q000378:metabolism; D008861:Microsomes / Q000378:metabolism; D011817:Rabbits
D000662:Amphetamines; D001589:Benzphetamine; C008669:norbenzphetamine; C005368:N-hydroxyamphetamine; D003577:Cytochrome P-450 Enzyme System; D008797:Metyrapone