Corticosteroid inhibition of biosynthesis of lung surfactant phospholipids in early human pregnancy.
Lung slices from human mid-trimester fetuses were incubated for 3 days. Hydrocortisone tended to decrease the biosynthesis of pulmonary phospholipids. It is suggested that cell proliferation is inhibited without inducing functional maturity.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D011247:Pregnancy; D011663:Pulmonary Surfactants / Q000096:biosynthesis*
D000305:Adrenal Cortex Hormones; D011663:Pulmonary Surfactants