[Effect, on kidney structure, of the use of antitumor preparations combined with diacarb and furosemide].
It has been shown in experiments on rats with transplanted sarcoma 45 that cyclophosphane (10 mg/kg) and 6-mercaptopurine (25 mg/kg) produced hemodynamic changes in the kidneys, as well as swelling of the endothelium of the glomerular capillaries and of the epithelium of the tubules, and focal interstitial fibrosis. Concurrent administration of antineoplastic drugs with diacarb (200 mg/kg) or furosemide (50 mg/kg) returned the hemodynamics to normal and reduced nephrotoxicity of the antineoplastic drugs used.
D000086:Acetazolamide / Q000627:therapeutic use*; D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005665:Furosemide / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D015122:Mercaptopurine / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy
D005665:Furosemide; D003520:Cyclophosphamide; D015122:Mercaptopurine; D000086:Acetazolamide
Vliianie ne strukturu pochek sochetannogo primeneniia protivo-opukholevykh preparatov s diakarbom i furosemidom.