DSIP-like immunoreactivity in the developing rat brain.
Delta sleep-inducing peptide (DSIP) is a naturally occurring nonapeptide that has been reported to affect sleep. The concentration of DSIP-like material was measured by a highly specific radioimmunoassay in brain tissue from developing rats. DSIP-like immunoreactivity was present in fetal brain at increased levels shortly before birth. In one experiment, a significant elevation in the concentration of the peptide occurred at postnatal day 20, but in a second, similar, study the increase occurred later. No marked differences in the levels of DSIP-like immunoreactivity were found in the brains of rats injected 2 months earlier with DSIP or among 10 parts of brains obtained at postnatal day 20. Regardless of the function of DSIP, it is available to the rat throughout early development.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000196:embryology; D001923:Brain Chemistry; D003701:Delta Sleep-Inducing Peptide; D005260:Female; D005865:Gestational Age; D008297:Male; D009842:Oligopeptides / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D009842:Oligopeptides; D003701:Delta Sleep-Inducing Peptide