Arsenic-related hepatic angiosarcoma.
Data from several small autopsy series in German vintners in the 1940s and 1950s and a number of case reports have previously suggested that arsenic is a cause of hepatic angiosarcoma (HAS). In a nationwide review of deaths from HAS in the United States, we identified seven cases with a history of prolonged use of Fowler's solution (inorganic potassium arsenite), which provide further support for the association of arsenic exposure and HAS. An epidemiologic study of a cohort of individuals treated long-term with Fowler's solution might confirm this association.
D000328:Adult; D001151:Arsenic / Q000009:adverse effects*; D018053:Arsenites; D001249:Asthma / Q000188:drug therapy; D004781:Environmental Exposure; D005260:Female; D006394:Hemangiosarcoma / Q000139:chemically induced*; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000009:adverse effects; D017680:Potassium Compounds; D014481:United States; D014752:Vinyl Chloride / Q000009:adverse effects
D018053:Arsenites; D017680:Potassium Compounds; C009003:potassium arsenite solution; D001151:Arsenic; D011188:Potassium; D014752:Vinyl Chloride