Impairment of thermoregulatory cooling behavior by single cortical spreading depression in the rat.
Effects of single waves of unilateral cortical spreading depression (CSD) on skin-cooling operant behavior were studied in the rat with and without unilateral lesion in the preoptic and anterior hypothalamus (PO/AH). The skin-cooling behavior was severely suppressed for 6 min, with a resulting rise in rectal temperature (Tre), when CSD entered the frontal cortex contralateral to the PO/AH lesion. However, CSD ipsilateral to the PO/AH lesion slightly suppressed the skin-cooling behavior for 4 min with small rise in Tre. In the PO/AH intact rat, while 0.9% NaCl did not affect the skin-cooling behavior, unilateral CSD slightly suppressed it for 3 min almost in the same way as that of the ipsilateral CSD trial in the PO/AH lesioned rat. The results add further evidence to support the involvement of the frontal cortex in the central control of thermoregulation.
D000818:Animals; D007025:Anterior Hypothalamic Nucleus / Q000502:physiology*; D001833:Body Temperature Regulation; D001931:Brain Mapping; D003216:Conditioning, Operant / Q000502:physiology*; D013181:Cortical Spreading Depression; D005625:Frontal Lobe / Q000502:physiology*; D008297:Male; D011301:Preoptic Area / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains