Ivermectin, a new broad-spectrum antiparasitic agent.
22,23-Dihydroavermectin B1, ivermectin, derived from avermectin B1 by selective hydrogenation using Wilkinson's homogenous catalyst [Ph3P)3RhCl], was shown to be a highly effective drug for the treatment of a wide variety of metazoan parasitic diseases in animals.
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000627:therapeutic use; D002417:Cattle; D004187:Disaccharides / Q000138:chemical synthesis / Q000494:pharmacology; D006373:Helminthiasis / Q000188:drug therapy; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy; D007559:Ivermectin / Q000031:analogs & derivatives; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology; D012756:Sheep
D000871:Anthelmintics; D004187:Disaccharides; D007783:Lactones; D007559:Ivermectin; C019264:avermectin