title: Holistic protocol: hereditary polymorphic light eruption.
abstract: Hereditary polymorphic light eruption (HPLE) is a skin disorder of American Indians inherited as an autosomal dominant trait with reduced penetrance. Skin lesions which erupt on sun-exposed areas only are manifest clinically in many forms and are induced by ultraviolet radiation. The eruptions flare during the spring, summer and early fall and abate in late fall and winter. The course of the disorder over an individual's lifetime is erratic with unpredictable remissions and exacerbations. Treatment broadly includes protective measures, topical agents and systemic agents; all are long term and complex, demanding considerable life adjustment for the patient. Complications include streptococcal pyoderma and psychosocial trauma. Approaching and educating the patient holistically is an essential requirement for a practitioner participating in the care of a patient with HPLE.
mesh_terms: D002338:Carotenoids / Q000627:therapeutic use; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D003879:Dermatologic Agents / Q000627:therapeutic use; D005260:Female; D011564:Furocoumarins / Q000627:therapeutic use; D006801:Humans; D007198:Indians, North American; D008297:Male; D010787:Photosensitivity Disorders / Q000235:genetics* / Q000628:therapy; D013472:Sunlight; D014481:United States; D019207:beta Carotene
chemical_list: D003879:Dermatologic Agents; D011564:Furocoumarins; D019207:beta Carotene; D002338:Carotenoids