Ethanol tolerance measured electrophysiologically in hippocampal slices and not in neuromuscular junctions from chronically ethanol-fed rats.
The electrophysiologically measured effects of perfused ethanol were examined in neuromuscular junctions and hippocampal slices removed concurrently from naive and ethanol-tolerant rats. At the neuromuscular junction, ethanol augmented the frequency height, and half-width of spontaneous miniature endplate potentials (Mepp). No tolerance was noted to these effects in junctions from ethanol-fed animals. Ethanol depressed the stratum radiatum evoked hippocampal CA1 population spike. Clearcut tolerance to this effect was noted in slices from chronically ethanol-fed animals.
D000437:Alcoholism / Q000503:physiopathology; D000818:Animals; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009469:Neuromuscular Junction / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol