title: Changes in EEG, blood levels, mood scales and performance scores during long term treatment with diazepam, phenobarbital or placebo in patients.
abstract: 1. The patient population consisting of fifteen patients was divided into three groups, namely: diazepam group, phenobarbital group and placebo group. After three weeks the medicated groups were switched to placebo for a week and the placebo group was given phenobarbital. 2. The parameters to be assessed once a week comprised frequency-analyzed EEG recordings, performance in two attention tests and subjectively estimated mood modalities. 3. The EEG analysis suggested that EEG patterns: a) were drug-dependent, with a differential distribution for each drug of the four frequency bands analyzed; b) showed no change during the three-week treatment period; c) changed on cessation of medication or on switch from placebo to active medication; d) were task-dependent and changed in a systematic way with the level of activation (stress, vigilance or relaxation). 4. The results would allow a better understanding of the clinical course, the choice of therapeutic measures and of the underlying mechanisms of action.
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000188:drug therapy / Q000503:physiopathology; D001143:Arousal / Q000187:drug effects; D003975:Diazepam / Q000097:blood / Q000627:therapeutic use*; D004569:Electroencephalography; D004644:Emotions / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D010634:Phenobarbital / Q000097:blood / Q000627:therapeutic use*; D011597:Psychomotor Performance / Q000187:drug effects*; D013997:Time Factors
chemical_list: D003975:Diazepam; D010634:Phenobarbital