[Oriented migration of rat polymorphonucleocytes induced by 4-hydroxynonenal and formylmethionyl-leucyl-phenylalanine].
The influence of the preincubation with 4-hydroxy-2,3-trans-nonenal (HNE) or formylmethionyl-leucyl-phenylalanine (fMLP) on the oriented migration of rat polymorphonuclear leukocytes (PMN) stimulated by fMLP or HNE, respectively, was investigated. Further, the chemotactic effect of the two agents assayed together at doses deprived alone of chemotactic power, was determined. Our results show that the preventive contact of PMN with HNE does not affect the ability of the leukocytes to respond chemotactically to fMLP. Similarly, the cell preincubation with fMLP is unable to influence the HNE chemotactic power. Doses of HNE or fMLP that are not chemotactic alone, stimulate significantly the PMN oriented migration when assayed together.
D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D004357:Drug Synergism; D008297:Male; D008715:Methionine / Q000031:analogs & derivatives*; D009239:N-Formylmethionine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009240:N-Formylmethionine Leucyl-Phenylalanine; D009504:Neutrophils / Q000187:drug effects; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats
D000447:Aldehydes; D009842:Oligopeptides; D009239:N-Formylmethionine; D009240:N-Formylmethionine Leucyl-Phenylalanine; D008715:Methionine; C027576:4-hydroxy-2-nonenal
Studi sulla migrazione orientata di polimorfonucleati di ratto indotta dal 4-idrossinonenale e dalla formilmetionil-leucil-fenilalanina.