title: Propoxyphene and acetaminophen. Possible effects on the fetus.
abstract: Propoxyphene (Darvon) and acetaminophen (Tylenol) are widely prescribed analgesic agents. Both can cross the placenta, and propoxyphene can produce serious withdrawal symptoms in newborns. Neither propoxyphene nor acetaminophen is considered a teratogen, yet, three malformed infants who were antenatally exposed to propoxyphene have previously been reported. We report a fourth case of an infant, with withdrawal symptoms and cranial-facial and digital malformations, born to a women who used propoxyphene and acetaminophen throughout her pregnancy. We suggest that possibility that the antepartum use of propoxyphene and acetaminophen, in combination, may be teratogenic.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000015:Abnormalities, Multiple / Q000139:chemically induced*; D000082:Acetaminophen / Q000009:adverse effects*; D011431:Dextropropoxyphene / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005145:Face / Q000002:abnormalities; D005260:Female; D005385:Fingers / Q000002:abnormalities; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000139:chemically induced; D008297:Male; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D011247:Pregnancy; D012886:Skull / Q000002:abnormalities; D013375:Substance Withdrawal Syndrome / Q000209:etiology*
chemical_list: D000082:Acetaminophen; D011431:Dextropropoxyphene