Arterial thromboembolism and associated antithrombin III deficiency.
A patient with antithrombin III (ATT) deficiency after arterial embolism manifested an increasing requirement for heparin to adjust a partial thromboplastin time. This was corrected by dramatically increasing doses of heparin and by conversion to warfarin sodium. "Heparin-resistance" should direct the physician to examine antithrombin III levels, and ATT levels should be determined as a baseline before anticoagulation therapy.
D020152:Antithrombin III Deficiency; D005263:Femoral Artery; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D013923:Thromboembolism / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D014859:Warfarin / Q000627:therapeutic use
D014859:Warfarin; D006493:Heparin