Pharmacokinetics of fluorescein-labelled glycosaminoglycans and of their lipoprotein lipase-inducing activity in the rat.
Using fluorescein-labelled glycosaminoglycans (F-GAG) an extensive study of their pharmacokinetics and of pharmacokinetics of their lipoprotein lipase-inducing activity was carried out in fed and fasted rats. A two-compartment model was used to describe F-GAG's pharmacokinetics. The parameters of drug disposition were strongly dose-dependent. The dose-response curves for parameters were powers with negative exponent indicating considerable saturation of the F-GAG elimination process. There was also dose dependence for T1/2, Co, AUC and Cl, and the decrease in lipoprotein lipase activity in plasma was strongly dose-dependent. The lipoprotein lipase kinetic parameters also appeared to be dose-dependent.
D000818:Animals; D004790:Enzyme Induction / Q000187:drug effects; D019793:Fluorescein; D005452:Fluoresceins / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism* / Q000494:pharmacology; D007700:Kinetics; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005452:Fluoresceins; D006025:Glycosaminoglycans; D008071:Lipoprotein Lipase; D019793:Fluorescein