The influence of pH on the healing-over of mammalian cardiac muscle.
The process of healing-over was followed in trabeculae from the right ventricle of guinea-pigs and in Purkinje fibres from dogs by measuring resting potential and input resistance close to a site of damage. In Ca2+-free bathing solution at pH 6.5 no signs of healing-over were found; at pH 5.5 healing-over was incomplete; at pH 5.0 and 4.0 healing-over occurred promptly. It is concluded that transformation of low-resistance nexus membranes into high-resistance membranes separating the intracellular from the extracellular compartment normally is due to Ca2+, while protons can bring about the same effect under extreme conditions.
D000818:Animals; D002118:Calcium / Q000502:physiology*; D004285:Dogs; D006168:Guinea Pigs; D006321:Heart / Q000503:physiopathology; D006335:Heart Injuries / Q000503:physiopathology*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008564:Membrane Potentials; D011690:Purkinje Fibers / Q000503:physiopathology; D013997:Time Factors; D014945:Wound Healing
D002118:Calcium