[Cyclophosphamide haemorragic cystitis in a child. Radiological and endoscopic aspects (author's transl)].
Haemorragic cystitis is a well known complication of cyclophosphamide therapy. In the reported case, a 7 years old boy treated for lymphosarcoma, as an excretory urogram demonstrated important focal irregularity of the bladder wall. Cystoscopy revealed areas of important bullous oedema with generalized hyperemia. A biopsy disclosed normal urothelium raised by oedematous and congestive chorion and excluded a malignant tumor. Various kinds of endoscopic and surgical procedures are reported to control persisting hematuria after withdrawal of the cyclophosphamide treatment.
D002648:Child; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000627:therapeutic use; D003556:Cystitis / Q000139:chemically induced* / Q000175:diagnosis; D003558:Cystoscopy; D006417:Hematuria / Q000139:chemically induced; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D010610:Pharyngeal Neoplasms / Q000188:drug therapy; D001743:Urinary Bladder / Q000473:pathology; D014567:Urography
D003520:Cyclophosphamide
Cystite hémorragique au cyclophosphamide chez un enfant. Aspects radiologiques et endoscopiques.