title: Location response to a startling noise depends on the preferred grooming site in mice.
abstract: The exploratory behavior of adult male Balb/c mice was observed in both a small black box and an open field. The normal exploratory pattern included a strong tendency to groom in a preferred place (G-site); thus, an average of 86% (black box) and 92% (open field) of the total grooming time was spent in a single location, specific for each animal and environment. The response of the animals to a 2-sec, 100 dB auditory stimulus varied according to their location. If the unexpected sound occurred when the mice were in their G-site, they remained there an average of 67% (black box) and 75% (open field) of the trials. If elsewhere, they escaped and ran to their G-site 89% (black box) and 73% (open field) of the times. Mice treated with diazepam (5 mg/kg) showed the normal tendency to groom in a preferred place, but never escaped after the stimulus, even if it occurred when they were outside their G-site, nor did they resume normal exploratory behavior. It seems that the preferred grooming location is the place that serves as a refuge from an aversive noise signal, but only the latter behavior is abolished by diazepam, presumably by reduction of stress.
mesh_terms: D000818:Animals; D003975:Diazepam / Q000494:pharmacology; D004924:Escape Reaction / Q000187:drug effects; D005106:Exploratory Behavior; D006120:Grooming; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009622:Noise; D011930:Reaction Time / Q000187:drug effects; D013216:Reflex, Startle / Q000187:drug effects
chemical_list: D003975:Diazepam