The effect of felodipine on ventricular fibrillation after coronary artery ligation in the anaesthetized pig.
A 10 min ligation of the left anterior descending coronary artery in anaesthetized pigs resulted in ventricular fibrillation (VF) in 70% of control and propranolol-treated animals. Felodipine (10 nmol kg-1) not only reduced ventricular ectopic activity by 90%, but also completely abolished VF. When a second occlusion was applied after 20 min of reperfusion, felodipine was less effective against VF, possibly due to decreasing felodipine concentrations or only a transient increase in VF threshold.
D000758:Anesthesia; D000818:Animals; D000889:Anti-Arrhythmia Agents; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003331:Coronary Vessels / Q000502:physiology*; D015736:Felodipine; D006339:Heart Rate / Q000187:drug effects; D009543:Nifedipine / Q000031:analogs & derivatives / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology*; D013552:Swine; D014693:Ventricular Fibrillation / Q000503:physiopathology*
D000889:Anti-Arrhythmia Agents; D011725:Pyridines; D011433:Propranolol; D009543:Nifedipine; D015736:Felodipine