Studies of the thymus in mice bearing the Lewis lung carcinoma. I. Thymic natural killer cell activity in 3LL tumor-bearing mice.
Natural killer (NK) cell activity of spleen and thymus was studied in Lewis lung carcinoma (3LL)-bearing mice. A high level of hydrocortisone-sensitive NK cell cytotoxicity was found in the thymus after excision of the primary tumor, but not in nonamputated mice. Conversely, splenic NK cell activity was diminished in nonamputated tumor-bearing mice and remained unmodified in amputated tumor-bearing mice. Excision of the primary tumor prevented tumor-induced thymic atrophy and splenomegaly. Histological study of the thymus revealed the presence of metastatic cells within the cortex. These data suggest that NK cells or their precursors are present in the thymus and can be triggered or unmasked in situ by tumor cells migrating from the primary tumor.
D000373:Agglutinins / Q000276:immunology; D000818:Animals; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000276:immunology* / Q000601:surgery; D009929:Organ Size; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology* / Q000473:pathology
D000373:Agglutinins; D006854:Hydrocortisone