Hemopoietic stem cells in the liver of mice with Friend leukemia.
Hemopoietic stem cells were studied in the marrow, spleen and liver of individual, FV-P infected DBA/2 mice. At more than 17 days after infection there was a tendency for CFU-EI numbers in the spleen to be reduced compared to earlier intervals after virus infection; CFU-EI numbers in the marrow were low. At the same time all hemopoietic stem cells (CFU-S, CFU-C, BFU-E and CFU-EI) could be found in the enlarged liver. The migration of stem cells from the marrow to the spleen and further to the liver is discussed.
D000818:Animals; D003114:Colony-Forming Units Assay; D005260:Female; D005622:Friend murine leukemia virus; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D007942:Leukemia, Experimental / Q000473:pathology*; D008099:Liver / Q000166:cytology*; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D009929:Organ Size; D013154:Spleen / Q000166:cytology; D013163:Splenomegaly / Q000473:pathology