Assessment of the allergenic potential of althesin and its constituents.
The pharmaceutical formulation of Althesin was shown to have a weak allergenic potential in the guinea pig maximization test. Alphadolone and alphaxalone acetate were found to be devoid of such potential, while the status of Cremophor EL remained equivocal.
D000530:Alfaxalone Alfadolone Mixture / Q000276:immunology*; D000777:Anesthetics / Q000276:immunology; D000818:Animals; D004342:Drug Hypersensitivity / Q000276:immunology*; D005260:Female; D005990:Glycerol / Q000031:analogs & derivatives / Q000276:immunology; D006168:Guinea Pigs; D007428:Intradermal Tests; D008297:Male; D011277:Pregnanediones / Q000276:immunology
D000777:Anesthetics; D011277:Pregnanediones; C000515:cremophor EL; D000530:Alfaxalone Alfadolone Mixture; C006477:alphaxalone; C033418:alphadolone; D005990:Glycerol