Hypoparathyroidism during pregnancy: treatment with calcitriol.
A pregnant woman suffering from idiopathic hypoparathyroidism was treated with calcitriol [0.5-2 micrograms/day 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3)]. Her twin infants were delivered by cesarian section at 37 weeks of gestation. Laboratory investigations in the perinatal period disclosed: 1) normal serum calcium and phosphorus levels in the mother, 2) normal babies with no clinical or biochemical signs of hyperparathyroidism, 3) a low serum level of 25-hydroxyvitamin D despite a normal serum level of 1,25-(OH)2D in the mother, and 4) a low level of 25-hydroxyvitamin D and a high level of 1,25-(OH)2D in cord serum in both infants. It is suggested that calcitriol is an effective treatment of hypoparathyroidism during pregnancy and produces no ill effects on the baby.
D000328:Adult; D002117:Calcitriol; D002118:Calcium / Q000097:blood; D004100:Dihydroxycholecalciferols / Q000097:blood / Q000627:therapeutic use*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use*; D007011:Hypoparathyroidism / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D007231:Infant, Newborn; D008297:Male; D010710:Phosphates / Q000097:blood; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000188:drug therapy*
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D010710:Phosphates; D002117:Calcitriol; D002118:Calcium