Serum triglyceride elevation following high-dose vitamin A treatment for pityriasis rubra pilaris.
We describe two patients with pityriasis rubra pilaris in whom hypertriglyceridemia developed following the oral administration of high-dose vitamin A (retinol). The effects of transient hypertriglyceridemia are unknown, as both patients tolerated high-dose vitamin A therapy with minor, if any, other side effects. Both patients had minimal clinical improvement with this therapy. Patients being treated with 1,000,000 IU of vitamin A each day for ten to 14 days should have frequent determinations of serum lipid levels and liver function during the period of drug administration.
D006801:Humans; D008297:Male; D008875:Middle Aged; D010916:Pityriasis Rubra Pilaris / Q000188:drug therapy*; D014280:Triglycerides / Q000097:blood*; D014801:Vitamin A / Q000008:administration & dosage / Q000009:adverse effects*
D014280:Triglycerides; D014801:Vitamin A