Patulin biosynthesis: enzymatic and nonenzymatic transformations of the mycotoxin (E)-ascladiol.
A mycotoxin, (E)-ascladiol, was established as a direct precursor of patulin in cell-free preparations of Penicillium urticae patulin-minus mutants J1 and S11, but not S15. Isomerization to a side product, (Z)-ascladiol, was nonenzymatically catalyzed by sulfhydryl compounds.
D002474:Cell-Free System; D005663:Furans / Q000032:analysis / Q000378:metabolism*; D007536:Isomerism; D009183:Mycotoxins / Q000032:analysis / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D010365:Patulin / Q000096:biosynthesis*; D010407:Penicillium / Q000201:enzymology / Q000378:metabolism*; D011714:Pyrans / Q000096:biosynthesis*; D013057:Spectrum Analysis; D013438:Sulfhydryl Compounds / Q000494:pharmacology
D005663:Furans; D009183:Mycotoxins; D011714:Pyrans; D013438:Sulfhydryl Compounds; C038422:ascladiol; D009249:NADP; D010365:Patulin