Systemic versus intracoronary thrombolysis in acute myocardial infarction.
A short review of published report shows that the recanalization rate of a completely occluded coronary artery by intravenous streptokinase (SK) infusion was of 58%, somewhat less than the 77% reported for intracoronary SK application. The thrombus lysis time lasts somewhat longer with intravenous SK infusion as compared with intracoronary application. Time to lyse an intracoronary clot largely depends on the age of the thrombus. Serial serum enzyme curves of MB-CK are very helpful to estimate the restoration of coronary blood flow. Angiographic evaluation of left ventricular wall motion abnormalities suggests that in early treated patients (less than 3 hours) jeopardized myocardium was preserved by early restoration of coronary blood flow during the acute stage of myocardial infarction.
D003331:Coronary Vessels; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D009203:Myocardial Infarction / Q000188:drug therapy*; D013300:Streptokinase / Q000008:administration & dosage*
D013300:Streptokinase