Case report 235. Ewing-like adamantinoma of the left radial head and neck.
Skeletal adamantinoma is a rare malignant bone tumor with a poorly understood histogenesis. The lesion is easily recognized by a distinctive microscopic pattern of anastomosing trabeculae of epithelial-like cells in a fibrous stroma. Ultrastructural evidence has been presented to support an origin from two widely-divergent cell types: an epithelial cell with squamous characteristics [12, 15] and a mesenchymal cell with endothelial features [5, 9]. An addition to the histogenetic controversy has been the recent description of a bone neoplasm with an adamantinoma-like growth pattern which proved both by subsequent histological evolution and ultrastructure, to have features of Ewing tumor [10]. The authors report a further example of this entity and suggest that it may be sufficiently distinctive within the adamantinoma group to merit the term Ewing-like adamantinoma. Consonant with increasing evidence supporting the concept of tumor "metaplasia" that transcends traditional concepts of epithelial-mesenchymal immutability, the authors propose that all adamantinomas arise from a common stem cell.
D000328:Adult; D000564:Ameloblastoma / Q000000981:diagnostic imaging / Q000648:ultrastructure*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000648:ultrastructure*; D006801:Humans; D008297:Male; D011859:Radiography; D011884:Radius / Q000000981:diagnostic imaging / Q000648:ultrastructure*