Effect of human chorionic gonadotropin on the plasma levels of testosterone, estradiol, sex hormone binding globuline and free testosterone in Klinefelter syndrome.
Preliminary experiments showed that a course of 3 X 5000 IU Human Chorionic Gonadotropin (HCG) every alternate day in 5 patients with Klinefelter Syndrome caused increment in the circulating levels of testosterone, estradiol, and Sex Hormone Binding Globuline (SHBG). The levels of free testosterone, however, declined in 3 subjects and recorded no change in the remaining two. Estradiol/testosterone ratio on day 0 showed high correlation (r = 0.853) with augmented SHBG. It has been postulated that higher amount of SHBG is perhaps potentiating a reduction in the bioavailability of testosterone.
D000328:Adult; D001682:Biological Availability; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D004958:Estradiol / Q000097:blood*; D006801:Humans; D007713:Klinefelter Syndrome / Q000097:blood / Q000188:drug therapy*; D008297:Male; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013739:Testosterone / Q000097:blood*
D006063:Chorionic Gonadotropin; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol