Systemic, bladder wall, and bladder tumor concentration of misonidazole following intravesical administration in the rat.
The hypoxic-cell radiosensitizer misonidazole was administered intravesically to normal and to bladder tumor-bearing female Fischer rats. Drug concentration was measured in the bladder wall, the tumor and in the serum using high pressure liquid chromatography at different times following administration. The data shows that misonidazole is readily adsorbed by the bladder wall and the tumor with tissue levels reaching up to 10 times those measured in the serum.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005260:Female; D008920:Misonidazole / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D009593:Nitroimidazoles / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors; D001743:Urinary Bladder / Q000032:analysis / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000032:analysis / Q000188:drug therapy / Q000378:metabolism*
D009593:Nitroimidazoles; D008920:Misonidazole