title: Toxicity but not arthritogenicity of Mycoplasma arthritidis for mice associates with the haplotype expressed at the major histocompatibility complex.
abstract: The use of inbred and congenic mouse strains established that toxicity and death induced by Mycoplasma arthritidis associates with the haplotype expressed at the murine major histocompatibility complex. Mice bearing H-2k and H-2d are susceptible, whereas those bearing H-2b are much more resistant. Mice susceptible to toxicity exhibited massive peritoneal adhesions and a decreased ability to clear organisms from the peripheral circulation. However, the severity of acute arthritis developing over a 3-month period was not statistically related to the haplotype expressed at the major histocompatibility complex. Lymphocyte activation in vitro by a soluble T-cell mitogen is also dependent on a similar haplotype expression.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D001170:Arthritis, Infectious / Q000235:genetics / Q000401:mortality; D005260:Female; D005838:Genotype; D006238:Haploidy; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H / Q000235:genetics*; D008810:Mice, Inbred C57BL / Q000235:genetics*; D009174:Mycoplasma / Q000276:immunology / Q000472:pathogenicity*; D009175:Mycoplasma Infections / Q000235:genetics / Q000401:mortality
chemical_list: D000907:Antibodies, Bacterial