Delayed alloimmunization using random single donor platelet transfusions: a prospective study in thrombocytopenic patients with acute leukemia.
A randomized study was performed in 54 thrombocytopenic patients with acute leukemia. Alloimmunization of recipients of random multiple-donor platelet concentrates (MD group) was compared to that of patients receiving random single-donor platelets (SD group). In the SD patients, formation of alloantibodies (mostly anti-HLA) occurred less frequently (p less than 0.002), after a longer time period (p less than 0.002), and after a higher number of transfusions (p less than 0.005) as compared to MD patients. SD patients also became refractory to random platelets less frequently (p less than 0.005), after a longer time period, and after a higher number of transfusions (p less than 0.02). In SD patients, the increments after the first and the last transfusion were in the same range, whereas in MD patients, the 1-hr (p less than 0.001) and the 24-hr (p less than 0.025) increments decreased from the first to the last transfusion. Thus, the use of random SD platelet transfusions postponed alloimmunization.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000918:Antibody Specificity; D000920:Antibody-Dependent Cell Cytotoxicity; D001782:Blood Donors; D001792:Blood Platelets / Q000276:immunology; D001803:Blood Transfusion / Q000379:methods; D005260:Female; D006801:Humans; D007114:Immunization / Q000517:prevention & control*; D007519:Isoantigens / Q000008:administration & dosage; D007938:Leukemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D013921:Thrombocytopenia / Q000209:etiology* / Q000628:therapy; D065227:Transfusion Reaction
D007519:Isoantigens