Antiparasitic effectiveness of ivermectin in the horse.
By way of a controlled trial, the anthelmintic efficacies of the injectable and paste formulations of ivermectin were evaluated in the horse. Treatment was given at the rate of 200 microgram/kg of body weight. Regardless of formulation, 100% removals were demonstrated for Strongylus vulgaris (intestinal), S edentatus, 2nd and 3rd instars of Gastrophilus nasalis and G intestinalis, "small strongyles," Triodontophorus serratus and T tenuicollis. Adult Cylicocyclus insigne populations were eliminated at the rates of 99.9% and 96.3% by the injectable and paste formulations, respectively. Levels of 4th-stage Cylicocyclus spp larvae, as detected in the luminal contents of the colon, were reduced by 88.3% and 33.2% by the injectable and paste formulations, respectively. There were no adverse tissue or behavioral reactions induced by either preparation of ivermectin.
D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D006373:Helminthiasis / Q000188:drug therapy / Q000469:parasitology; D006374:Helminthiasis, Animal; D006734:Horse Diseases / Q000188:drug therapy* / Q000469:parasitology; D006736:Horses; D007422:Intestines / Q000469:parasitology; D007559:Ivermectin; D007783:Lactones / Q000008:administration & dosage / Q000627:therapeutic use*
D000871:Anthelmintics; D007783:Lactones; D007559:Ivermectin