[Investigations on the percutaneous activity of a combination of heparin, allantoin and dexpanthenol in a specific ointment base, Antiinflammatory effect on UV-erythema in the guinea pig].
Compared to the ointment base, the application of a heparin-allantoin-dexpanthenol combination ointment (Hepathrombin ointment) to guinea pigs immediately after as well as 30 and 120 min prior to UV-irradiation effects more rapid regression of the erythema along with a reduction in erythema formation. After a pretreatment of 30 min, the temperature of the erythematous skin is also significantly lower. At a pretreatment of 120 min, no temperature differences can be observed between the ointment groups. This effect might result from a superimposition of the anti-erythematous/antiinflammatory effect of Hepathrombin along with a vasodilation effect on the deeper skin layers. The antiinflammatory effect of Hepathrombin is also discussed in connection with the mechanism of UV-induced erythema. The inhibition of UV-erythema by Hepathrombin underlines the rapid skin penetration of the active substances.
D000481:Allantoin / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents; D004338:Drug Combinations / Q000494:pharmacology; D004890:Erythema / Q000188:drug therapy*; D006168:Guinea Pigs; D006493:Heparin / Q000494:pharmacology*; D008297:Male; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D012881:Skin Temperature / Q000187:drug effects; D013997:Time Factors; D014466:Ultraviolet Rays
D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D010205:Pantothenic Acid; D000481:Allantoin; C013325:Ulcrux; D006493:Heparin
Untersuchungen zur perkutanen Wirksamkeit einer Heparin-Allantoin-Dexpanthenol-Kombination in spezieller Salbengrundlage. Antiinflammatorische Wirkung auf UV-Erytheme am Meerschweinchen.