Ticarcillin compared with carbenicillin in the treatment of exacerbations of bronchopulmonary infection in cystic fibrosis.
Sixteen adults with cystic fibrosis and chronic bronchopulmonary infection with Pseudomonas aeruginosa, admitted to hospital for chemotherapy, were randomized to treatment with either carbenicillin or ticarcillin. In addition all patients received gentamicin. Both antibiotic treatments produced clinical improvement and significant improvement in respiratory function, but there was no difference between them. Pseudomonas aeruginosa was not eradicated from sputum with either treatment regimen.
D000293:Adolescent; D000328:Adult; D001982:Bronchial Diseases / Q000188:drug therapy* / Q000209:etiology; D002228:Carbenicillin / Q000627:therapeutic use*; D003550:Cystic Fibrosis / Q000150:complications*; D004359:Drug Therapy, Combination; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D010406:Penicillins / Q000627:therapeutic use*; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000209:etiology; D013982:Ticarcillin / Q000627:therapeutic use*
D005839:Gentamicins; D010406:Penicillins; D013982:Ticarcillin; D002228:Carbenicillin