Sex difference of barbiturate-protection in experimental cerebral ischemia in spontaneously hypertensive rats (SHR).
Survival time following bilateral carotid occlusion was significantly longer in spontaneously hypertensive rats (SHR) anesthetized with barbiturate than in those with ether. Under barbiturate anesthesia, female SHR survived longer (16.6 h) than did males (10.9 h), whereas such sex difference was not found in those with ether anesthesia. The present results indicate sex difference of barbiturate-protection in cerebral ischemia.
D000654:Amobarbital / Q000633:toxicity*; D000768:Anesthesia, General; D000818:Animals; D004986:Ether / Q000633:toxicity*; D005019:Ethyl Ethers / Q000633:toxicity*; D005260:Female; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D002546:Ischemic Attack, Transient / Q000150:complications / Q000517:prevention & control*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D005019:Ethyl Ethers; D004986:Ether; D000654:Amobarbital