[Stress-ulcer prevention with pirenzepine-a controlled study].
In polytraumatised or septic patients without adequate medical prophylaxis the incidence-rate of postoperative complications is very high. The incidence-rate of acute mucosal stress lesions is to be expected 100 per cent. The parenteral application of pirenzepine shows in comparison to placebo a clear protective effect measured as incidence-rate of stress lesion (p greater than 0,05) and occurrence of bleeding (p greater than 0,01).
D001570:Benzodiazepinones / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D010437:Peptic Ulcer / Q000517:prevention & control*; D010438:Peptic Ulcer Hemorrhage / Q000517:prevention & control; D010879:Piperazines / Q000627:therapeutic use*; D010890:Pirenzepine; D011184:Postoperative Period; D013312:Stress, Physiological / Q000150:complications
D001570:Benzodiazepinones; D010879:Piperazines; D010890:Pirenzepine
Stressulkus-Prophylaxe mit Pirenzepin-eine kontrollierte Studie.