Manganese potentiation of autologous anti-Meth A tumor vaccines. A developmental study.
This study was set up to develop methods for increasing the potency of vaccines against pre-existing transplanted subcutaneous Meth A tumors in Balb/c mice. The vaccines were prepared from particles and surface membrane ghosts from Meth A cells, a transplantable lymphosarcoma originally induced in a Balb/c mouse with methylcholanthrene. It was not possible to increase vaccine potency by conventional methods, but a major increase was achieved by adding manganese and phosphate. Vaccines prepared with these substances stimulated significant numbers of mice to completely reject target tumors transplanted 3 days before immunization. Possible mechanisms for this manganese effect on vaccine potency are discussed in this paper.
D000818:Animals; D002462:Cell Membrane / Q000276:immunology; D004357:Drug Synergism; D005260:Female; D007167:Immunotherapy; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology / Q000628:therapy*; D008345:Manganese / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D012513:Sarcoma, Experimental / Q000276:immunology / Q000628:therapy
D008345:Manganese