[Mineralocorticoid-induced changes of vascular reactivity to noradrenaline and angiotensin II in baboons].
In experiments on normotensive baboons of both sex the vascular reactivity on angiotensin II and noradrenaline was studied after an 18-week administration of DOCA (2 mg/b.w./week i. m.) and of common sal (5 g/day with meals). Dosage and duration of DOCA administration was chosen to prevent hypertensive haemodynamic alterations. 40 to 240 seconds after an angiotensin II injection (0.5 micrograms/kg b.w.) the pressor, especially diastolic response in both narcotized and non-narcotized animals intensified markedly. Infusion of noradrenaline (1.0 micrograms/kg b.w./min for 5 min) called forth after 120 min a significant rise in diastolic BP. Described abnormal pressor response is considered to represent a suitable model of a vascular predisposition to hypertension.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001808:Blood Vessels / Q000187:drug effects; D005260:Female; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008901:Mineralocorticoids / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology*; D010215:Papio
D008901:Mineralocorticoids; D000804:Angiotensin II; D009638:Norepinephrine
Mineralokortikoidbedingte Veränderung der vaskulären Reaktivität auf Noradrenalin und Angiotensin II bei Pavianen.