[Comparative pharmacodynamic study of Cordanum and obzidan in stress angina pectoris patients].
The effect of different single doses of beta-blockers cordanum (talinolol) and obsidan was comparatively studied in 10 patients with angina pectoris of effort. The pharmacodynamic study was performed according to an original technique consisting in a sequence of monitored repeated identical treadmill exercise. The effect of the drug was evaluated by the reduction in ST-segment depression during exercise. Hemodynamic effect of cordanum was 1.7 lower than that of obsidan. The reduction of ST-segment depression effected by cordanum was 2.6 lower than in case of the corresponding doses of obsidan. The effect did not correlate with the heart rate and the double product; it terminated within 4--5 hrs.
D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy*; D004341:Drug Evaluation; D005080:Exercise Test; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D011412:Propanolamines / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use*; D013997:Time Factors
D011412:Propanolamines; C011550:talinolol; D011433:Propranolol
Sravnitel'noe farmakodinamicheskoe izuchenie kordanuma i obzidana u bol'nykh stenokardieĭ napriazheniia.