Influence of amphotericin B on leucine uptake in 3T3 cells.
By studying the effect of leucine competitors we found that activation of the specific leucine-transport system underlies the enhancement of leucine uptake in mouse 3T3 fibroblast cells induced by sublethal doses of Amphotericin B (synergic effect). The relation of the antibiotic activity and the alteration of the membrane cholesterol interaction with lipids is discussed.
D000596:Amino Acids / Q000494:pharmacology; D000666:Amphotericin B / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002478:Cells, Cultured; D007700:Kinetics; D007930:Leucine / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D051379:Mice
D000596:Amino Acids; C000111:azaleucine; D000666:Amphotericin B; D007930:Leucine