Observations on the permeability of the choriocapillaris of the eye.
The choriocapillaris is a fenestrated capillary bed located posterior to the retinal pigment epithelium. It serves as the main source of supply to the photoreceptors, retinal pigment epithelium, and other cells of the outer retina. The permeability of these capillaries to intravenously injected ferritin (MW - approx. 480,000; mol. diam. 11 nm) was examined in the mouse, rabbit, and guinea pig, each of which is characterized by a different type of retinal vascularization. In all three species, the bulk of the ferritin remained in the capillary lumina, where it appeared to be blocked at the level of the diaphragmed fenestrae. Some ferritin was present in endothelial cell vacuoles. The results confirm previous work on the rat choriocapillaris and indicate that the barrier function of the choriocapillary endothelium is present even among species in which the retinal circulation differs significantly.
D000818:Animals; D002199:Capillary Permeability; D002829:Choroid / Q000098:blood supply*; D005293:Ferritins / Q000378:metabolism; D006168:Guinea Pigs; D051379:Mice; D010857:Pigment Epithelium of Eye / Q000098:blood supply*; D011817:Rabbits; D013045:Species Specificity
D005293:Ferritins