Lupus-like syndrome--a rare complication in thionamide treatment for Graves' disease.
A patient with Graves' disease who experienced various allergic reactions to both PTU and MMI is reported. She developed fever, skin rash, lymphadenopathy, liver damage and moderate leukopenia during PTU administration. Furthermore, she developed an MMI-induced lupus-like syndrome characterized by generalized lymphadenopathy, migrating, polyarthritis and myalgia, and results of tests for anti-DNA antibody and anti-nuclear antibody, and LE were positive. All these abnormalities reverted to normal upon discontinuation of medication after subtotal thyroidectomy.
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D006111:Graves Disease / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced*; D008713:Methimazole / Q000009:adverse effects*; D011433:Propranolol / Q000627:therapeutic use; D011441:Propylthiouracil / Q000009:adverse effects*; D013965:Thyroidectomy
D001323:Autoantibodies; D008713:Methimazole; D011441:Propylthiouracil; D003907:Dexamethasone; D011433:Propranolol