title: Occupational nitrosamine exposure. 1. Rubber and tyre industry.
abstract: To determine the role of N-nitrosamines in the known increased cancer risk of rubber workers, air concentrations of such carcinogens were measured by area sampling or personal monitoring in 19 factories. N-Nitrosodimethylamine (NDMA) and N-nitrosomorpholine (NMOR) were found regularly, the air concentrations varying between 0.1 and 380 micrograms/m3 personal monitoring. The mean concentration was usually in the range of 1-10 micrograms/m3. Several other nitrosamines could be detected in certain production branches. In retail shops and storage rooms of tyres NDMA and NMOR were found. Most rubber chemicals based on amines are contaminated with N-nitrosamines, but this contamination cannot explain the air concentrations of nitrosamines found. The occurrence of nitrosamines mainly depends upon their formation during production of rubber and rubber products from used vulcanisation accelerators based on amines and the presence of nitrosating agents, such as diphenylnitrosamine (retarder A) and of nitrous gases, in products or production areas. Elimination of one or both precursors for nitrosamine formation resulted in significant reduction of airial contamination of nitrosamines. The results are discussed in regard to the mechanisms of nitrosamine formation during rubber production, as basis for future epidemiological studies and their potential for exposure prevention.
mesh_terms: D000393:Air Pollutants / Q000032:analysis*; D000395:Air Pollutants, Occupational / Q000032:analysis*; D002273:Carcinogens / Q000032:analysis*; D004128:Dimethylnitrosamine / Q000032:analysis*; D006801:Humans; D008834:Microclimate; D009602:Nitrosamines / Q000032:analysis*; D009784:Occupational Diseases / Q000517:prevention & control; D012408:Rubber
chemical_list: D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D002273:Carcinogens; D009602:Nitrosamines; C002741:N-nitrosomorpholine; D012408:Rubber; D004128:Dimethylnitrosamine