Cardiac denervation and adrenalectomy. Its effects on myocardial lesions of hemorrhagic shock in dogs.
Myocardial lesions were seen in dogs subjected to experimental hemorrhagic shock. In contrast, dogs that had been previously surgically treated by cardiac denervation and adrenalectomy, showed less myocardial damage. The latter group also had a substantially decreased myocardial I-norepinephrine content and a much lower plasma I-norepinephrine response to shock when compared with the control shock dogs. In contrast, "sham shock" dogs had no myocardial lesions, and normal myocardial and plasma I-norepinephrine contents.
D000315:Adrenalectomy; D000818:Animals; D003714:Denervation; D004285:Dogs; D005260:Female; D006321:Heart / Q000294:innervation*; D006352:Heart Ventricles / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000473:pathology*; D009638:Norepinephrine / Q000378:metabolism; D012771:Shock, Hemorrhagic / Q000378:metabolism / Q000473:pathology*; D013562:Sympathectomy
D009638:Norepinephrine