[Effect of choline compounds on rosette formation in mouse lymphocytes].
The effects of some choline compounds (acetylcholine, benzoylcholine, phosphorylcholine) on immune rosette-formation were studied in experiments on 150 BALB/c mice immunized with sheep red blood cells. Low concentration of the choline-containing substances (from 10(-14) to 10(-12) M) stimulated immune rosette-formation, whereas high concentrations (from 10(-8) to 10(-5) M) inhibited it. The blockade of lymphocyte cholinoreceptors with atropine reversed the action of phosphorylcholine on the processes of rosette-formation. Interaction of immune and mediator receptors is discussed.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001588:Benzoylcholine / Q000494:pharmacology*; D002794:Choline / Q000031:analogs & derivatives*; D051379:Mice; D008807:Mice, Inbred BALB C; D010767:Phosphorylcholine / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000187:drug effects; D012397:Rosette Formation
D011950:Receptors, Cholinergic; D010767:Phosphorylcholine; D001588:Benzoylcholine; D001285:Atropine; D002794:Choline; D000109:Acetylcholine
O vliianii nekotorykh soedineniĭ kholina na rozetkoobrazovanie limfotsitov u mysheĭ.