Induction of angiogenic tumors in the duodenum of female Donryu rats by continuous oral administration of N-isobutyl-N-nitrosourea.
Four groups of female Donryu rats were continuously given 400, 200, 100 or 0 ppm N-isobutyl-N-nitrosourea (iso-BNU) in their drinking water, and were examined for the development of tumors. The incidence of digestive tract tumors was 25/28 (89%), 14/24 (58%), 6/25 (24%) and 0/17 (0%), in the 400, 200, 100 and 0 ppm groups, respectively. The predominant type of digestive tract tumor was angiogenic, and a few were of the epithelial type. A dose-effect relationship was clearly demonstrated not only in the incidence of digestive tract tumors but also in the average survival period of rats with these tumors.
D000284:Administration, Oral; D000818:Animals; D002273:Carcinogens; D004305:Dose-Response Relationship, Drug; D004379:Duodenal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006390:Hemangioendothelioma / Q000139:chemically induced; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009383:Neoplasms, Vascular Tissue / Q000139:chemically induced*; D009607:Nitrosourea Compounds / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
D002273:Carcinogens; D009607:Nitrosourea Compounds; C039003:N-isobutyl-N-nitrosourea