title: In vivo-in vitro correlations with a commercial dissolution simulator II: papaverine, phenytoin, and sulfisoxazole.
abstract: The dissolution profiles of 11 commercially available papaverine, phenytoin, and sulfisoxazole dosage forms were determined using a dissolution simulator. The products had been the subject of earlier in vivo bioavailability studies with human subjects. The use of an absorption simulator, which is designed to provide an estimate of the optimum sampling scheme for the dissolution simulator, did not provide useful data for this purpose. Good in vivo-in vitro correlations were found for the papaverine dosage forms, which included nine controlled-release products. Less satisfactory correlations were obtained for the phenytoin capsules and the sulfisoxazole tablet products.
mesh_terms: D000042:Absorption; D002626:Chemistry, Pharmaceutical / Q000295:instrumentation*; D010208:Papaverine / Q000032:analysis; D010672:Phenytoin / Q000032:analysis; D012995:Solubility; D013444:Sulfisoxazole / Q000032:analysis; D013997:Time Factors
chemical_list: D010672:Phenytoin; D013444:Sulfisoxazole; D010208:Papaverine