Evidence relating the inhibitory effect of cobalt on the activity of delta-aminolevulinate synthase to the intracellular concentration of porphyrins.
This study shows that the inhibition of ALAS activity caused by cobalt is directly correlated with the intracellular porphyrin concentration, thus indicating that cobalt exerts its inhibitory effect on ALAS activity as a result of the formation of cobalt-protoporphyrin.
D000624:5-Aminolevulinate Synthetase / Q000037:antagonists & inhibitors*; D000818:Animals; D002642:Chick Embryo; D003035:Cobalt / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D011166:Porphyrins / Q000378:metabolism*
D011166:Porphyrins; D003035:Cobalt; D000624:5-Aminolevulinate Synthetase