title: Sexual development, maturation, and behavior.
abstract: The Y chromosome directs the primitive gonad to develop into a testis. Without a Y chromosome an ovary will develop, but that ovary will not be normal unless two X chromosomes are present. Active intervention is needed for male differentiation; internal male structures will not be found unless sufficient and effective testosterone is secreted by the immature testis to develop the wolffian duct system into the internal male reproductive tract. The testis must also secrete mullerian regression factor to cause the demise of the internal female duct structures. Finally, enough 5-alpha-reductase activity must be present to convert testosterone into dihydrotestosterone for the normal virilization of the male external genitalia. Without testosterone or its receptor sites, without dihydrotestosterone, and without mullerian regression factor, the reproductive system is female. Early in life, a child assumes both a gender identity (an awareness of what sex he or she belongs to) and a gender role (behavior deemed to be more or less characteristic of one sex or the other). As puberty is passed, sexual orientation becomes more obvious, although the development of that orientation has probably been in the making since early childhood. Early developmental hormone milieu and social environment undoubtedly all play a role in subsequent sexual behavioral patterns, but the extent to which each of these impacts upon that behavior still remains unknown.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D012734:Disorders of Sex Development / Q000235:genetics; D005260:Female; D005783:Gender Identity; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011606:Psychosexual Development; D011627:Puberty; D012729:Sex Chromosome Aberrations / Q000235:genetics; D012733:Sex Differentiation; D012725:Sexual Behavior / Q000502:physiology; D012741:Sexual Maturation
chemical_list: D012739:Gonadal Steroid Hormones