Fanconi's anemia: ultrastructural observations on erythroblasts.
A case of Fanconi's anemia is reported. Particular attention was given to the ultrastructure of the erythroblasts. The main abnormalities are summarized as follows: (1) striking polymorphism of all the erythroblasts, (2) multiple nuclear cisternae showing several breaks, (3) admixture of nucleus and cytoplasm, (4) myelinic figures inside nuclear cisternae and cytoplasm, (5) moth-eaten nucleus, and (6) total absence of normal erythroblasts. These abnormalities were still visible after therapy in spite of clinical and hematologic improvement.
D000741:Anemia, Aplastic / Q000473:pathology*; D002648:Child; D004900:Erythroblasts / Q000648:ultrastructure*; D004912:Erythrocytes / Q000648:ultrastructure*; D005199:Fanconi Anemia / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron