Studies of cytogenetic effects of sodium arsenicals on mammalian cells in vitro.
The cytotoxic and cytogenetic effect of sodium arsenite and sodium arsenate on Chinese hamster ovary (CHO) cells is reported. Chromosome aberrations were induced with both arsenic compounds. Trivalent arsenic was more clastogenic than pentavalent arsenic. Sodium arsenite was also shown to produce increased sister chromatid exchange in CHO cells and increased chromosome breakage in human lymphocytes.
D000818:Animals; D001149:Arsenates / Q000633:toxicity*; D001151:Arsenic / Q000633:toxicity*; D018053:Arsenites; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D009153:Mutagens / Q000633:toxicity*; D010053:Ovary / Q000166:cytology; D012854:Sister Chromatid Exchange; D017670:Sodium Compounds
D001149:Arsenates; D018053:Arsenites; D009153:Mutagens; D017670:Sodium Compounds; C017947:sodium arsenite; C009277:sodium arsenate; D001151:Arsenic