Diphenylhydantoin: an alternative ligand of a glucocorticoid receptor affecting prostaglandin generation in A/J mice.
Evidence for the binding of 5,5-diphenylhydantoin and glucocorticoids to a common receptor is presented for pulmonary and hepatic cytosols and thymocytes of A/J female mice. The 5,5-diphenylhydantoin-protein complex is absorbed by DNA cellulose, and is incorporated into nuclei, 5,5-Diphenylhydantoin, like glucocorticoids, inhibits the production of prostaglandins in thymocytes. Thus a common receptor is probably responsible for the inhibitory and teratogenic effects of these drugs.
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000818:Animals; D001667:Binding, Competitive; D002972:Cleft Palate / Q000139:chemically induced; D003907:Dexamethasone / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D051379:Mice; D010672:Phenytoin / Q000378:metabolism*; D011453:Prostaglandins / Q000096:biosynthesis*; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*; D013929:Thromboxane B2 / Q000096:biosynthesis
D011453:Prostaglandins; D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D010672:Phenytoin; D003907:Dexamethasone