Analgesic activity of carprofen on human experimental dental pain.
1. The effects of an orally administered single dose of placebo, acetylsalicyclic acid (ASA) and (d,1)-6-chloro-a-methyl carbazole-2-acetic acid (carprofen) have been evaluated on an experimental pain model by electrical stimulation of dental pulp in man. 2. ASA and carprofen showed a significant analgesic action, while placebo was ineffective. 3. Analgesic activity of ASA and carprofen was similar. The two drugs were ineffective in modifying the pain threshold; on the contrary, the tolerance to the strongest painful sensation was significantly increased.
D000328:Adult; D000700:Analgesics; D001241:Aspirin / Q000494:pharmacology; D002227:Carbazoles / Q000494:pharmacology*; D003782:Dental Pulp / Q000502:physiology; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D008297:Male; D010146:Pain / Q000503:physiopathology
D000700:Analgesics; D002227:Carbazoles; C007005:carprofen; D001241:Aspirin