Lack of correlation between transformed characteristics in culture and tumorigenicity of mouse mammary tumour cells.
Androgen responsive and unresponsive Shionogi 115 mouse mammary carcinoma cells have been examined for anchorage-independent growth and tumorigenicity in nude mice. The two cell types exhibit transformed and normal growth characteristics respectively, but both give rise to tumours in nude mice. No correlation between tumorigenicity and transformed characteristics including anchorage-independent growth could be demonstrated.
D000818:Animals; D002369:Castration; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008819:Mice, Nude; D013739:Testosterone / Q000378:metabolism
D013739:Testosterone