Synthesis of 3-dialkylaminopropyl-2-thiohydant derivatives as potential antiarrhythmic agents.
A series of 3-dialkylaminopropyl-5-monosubstituted-2-thiohydantoins were synthesized as potential antiarrhythmic agents; their pharmacological activity is comparable to that of quinidine, but weaker than that of phenytoin.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D004562:Electrocardiography; D005260:Female; D006827:Hydantoins / Q000138:chemical synthesis*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010672:Phenytoin / Q000494:pharmacology; D013867:Thiohydantoins / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000889:Anti-Arrhythmia Agents; D006827:Hydantoins; D013867:Thiohydantoins; D010672:Phenytoin