Modification by GABA-ergic agents and clonidine of morphine-induced convulsions and toxicity in rats.
Intracerebroventricular (i.c.v.) administration of morphine produced dose-dependent behavioural changes in rats, the highest dose producing violent tonic convulsions. Naloxone (up to 10 mg/kg i.p., or 100 micrograms i.c.v.) failed to reverse morphine-induced toxicity. The conventional anticonvulsant drugs also failed to offer protection to morphine-induced seizures. GABA-ergic substances, GABA, piracetam and diazepam, on the other hand, protected the animals against morphine-induced convulsions and toxicity. Similarly, clonidine pretreatment also had a protective action against morphine-induced convulsions.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology*; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors* / Q000633:toxicity; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D000927:Anticonvulsants; D009270:Naloxone; D005680:gamma-Aminobutyric Acid; D009020:Morphine; D003000:Clonidine