title: An HPLC method for analysis of clonazepam in serum.
abstract: A sensitive, accurate, and precise method for the analysis of clonazepam in serum was developed. The drug and internal standard from serum extracts were methylated to obviate carbamazepine interference and then resolved on a 5 micron C18 HPLC column. The mobile phase could also be used for many other basic drugs.
mesh_terms: D001570:Benzodiazepinones / Q000097:blood*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002998:Clonazepam / Q000097:blood*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008745:Methylation
chemical_list: D001570:Benzodiazepinones; D002998:Clonazepam