title: Studies on a new paste preparation of phenylbutazone.
abstract: The absorption characteristics of a new paste preparation of phenylbutazone were studied in ponies and thoroughbreds. The results suggested that at a similar dose rate of 5 mg/kg greater bioavailability results from the paste than from a powder preparation. Delivery of an accurate dosage of the paste was not possible using the multidose applicator. Repeated administration of the paste preparation (5 mg/kg twice daily) indicated that it is more toxic to both ponies and thoroughbreds than a powder preparation. In addition to the toxic manifestations previously reported, a neutropenia developed during administration. Repeated intravenous administration of phenylbutazone (3.3 mg/kg twice daily) for eight days produced no adverse effects.
mesh_terms: D000042:Absorption; D000818:Animals; D001682:Biological Availability; D006734:Horse Diseases / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D006736:Horses / Q000378:metabolism*; D007700:Kinetics; D009824:Ointments; D010653:Phenylbutazone / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism / Q000633:toxicity; D011208:Powders
chemical_list: D009824:Ointments; D011208:Powders; D010653:Phenylbutazone