[Expression of transformation characters in colchicine-resistant tumor cells].
Malignancy and anchorage independence of Djungarian hamster tumor cell lines resistant to different doses (0.1-5.0 micrograms/ml) of colchicine were studied. The clones with low colchicine resistance (15-20-fold) did not differ in tumorigenicity from parental cells. The TD50 for highly colchicine-resistant cells (200-800-fold) was several orders of magnitude higher than that for wild-type cells. Colchicine resistance did not affect the expression of the cells anchorage independence. The cloning efficiency in a semi-solid medium was the same both for colchicine-resistant cell lines and wild-type cells.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D003078:Colchicine / Q000494:pharmacology*; D006224:Cricetinae; D004351:Drug Resistance; D009374:Neoplasms, Experimental / Q000235:genetics; D010641:Phenotype
D003078:Colchicine
Proiavlenie priznakov transformatsii v opukholevykh kletkakh, rezistentnykh k kolkhotsinu.