Stimulation of in vitro fertilization in mice with 17 beta-estradiol.
The effect of various concentrations of estradiol on in vitro fertilization frequency was studied. Fertilization was stimulated by 5 X 10(-9) M 17 beta-estradiol but not by 5 X 10(-9) M 17 alpha-estradiol. At 5 X 10(-6), 5 X 10(-7), 5 X 10(-8), and 5 X 10(-10) M 17 beta-estradiol there was no difference in the fertilization frequency between test and control samples. It is suggested that stimulation of the acrosome reaction is instrumental in increasing the fertilization rate.
D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005307:Fertilization in Vitro / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D004958:Estradiol