[HLA DRW3 and Graves' disease (author's transl)].
HLA A, B, C antigens were studied in 86 caucasians with Graves' disease, using the lymphocytotoxicity microtechnique. Results were compared to those obtained in 336 healthy controls. HLA DR antigens were studied by the technique of microlymphocytotoxicity after long incubation and results compared to those of 100 healthy controls. There is an increased incidence of DRW3: 51.6% as compared to 20% in controls with a high degree of statistical significance pc less than 0,0003. There is also an increased incidence of B8: 44,19% in Graves' disease against 22,47% in controls pc less than 0,001. These results agree with the conclusions of two recent studies where the incidence of DW3 analyzed by a lymphocytic mixed culture was greater than incidence of the B8 antigen.
D005260:Female; D006111:Graves Disease / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D006801:Humans; D008297:Male
D006680:HLA Antigens
Système HLA et maladie de Basedow: prédominance de l'antigène DRW3.