Acute liver dystrophy with thrombosis of hepatic veins: a fatal complication of dacarbazine treatment.
In the course of adjuvant single-agent chemotherapy with dacarbazine after extirpation of malignant melanoma, a fatal complication was observed in four of our patients. During the second cycle of therapy liver failure due to massive hepatic necrosis supervened, with widespread thrombosis of liver veins. The clinical and pathologic features of our patients are compared with the findings in eight published cases. The possible pathogenesis is discussed in detail, and Budd-Chiari syndrome caused by an allergic thrombophlebitis with secondary liver cell necrosis seems to be most probable.
D056486:Chemical and Drug Induced Liver Injury; D003606:Dacarbazine / Q000009:adverse effects*; D005260:Female; D006503:Hepatic Veins; D006801:Humans; D008107:Liver Diseases / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000188:drug therapy*; D008875:Middle Aged; D009336:Necrosis; D012878:Skin Neoplasms / Q000188:drug therapy; D013927:Thrombosis / Q000139:chemically induced* / Q000473:pathology
D003606:Dacarbazine