Efficacy of aerosolized methylprednisolone in an animal model of aspiration pneumonitis.
Methylprednisolone (MPSS, 30 mg/kg) was administered intrabronchially by nebulization 15 min after HCl aspiration in anesthetized dogs. Control animals (SALINE group) received saline nebulization without steroid. Hemodynamic and oxygenation variables were determined before and 1, 2 and 3 hr after aspiration. At autopsy, lungs were removed and desiccated for gravimetric determination of lung water. Three hr postaspiration, intrapulmonary shunting (Qsp/Qt) in the MPSS group was significantly lower (22 vs 41%) and arterial oxygen tension (PaO2) was higher (265 vs 122 torr) than in the SALINE group. Thus, direct application of this glucocorticoid to airway membranes following acid aspiration improved gas exchange without obvious benefit to edema formation or cardiac output.
D000336:Aerosols; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D008775:Methylprednisolone / Q000008:administration & dosage*; D010101:Oxygen Consumption / Q000187:drug effects; D011015:Pneumonia, Aspiration / Q000188:drug therapy*; D011654:Pulmonary Edema / Q000188:drug therapy
D000336:Aerosols; D008775:Methylprednisolone