[Use of prospidin in the combination chemotherapy of recurrences of generalized forms of lymphogranulomatosis].
Combined chemotherapy (prospidin, cyclophosphamide, vincristine and prednisolone) (PCVP) was given to 32 patients with recurrent generalized forms of Hodgkin's disease. Remission was reliably established in 75% of patients; its mean duration was 2.8 months. 15 patients received repeated courses of complex chemotherapy, including prospidin; it proved effective in 12 of them. Mean duration of remission was 2.7 months. Toxic side--effects were insignificant and subsided quickly. The results of the study point to the effectiveness of PCVP scheme application in patients with recurrent generalized forms of Hodgkin's disease.
D000328:Adult; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000008:administration & dosage*; D011239:Prednisolone / Q000008:administration & dosage*; D011447:Prospidium / Q000008:administration & dosage*; D012008:Recurrence; D014750:Vincristine / Q000008:administration & dosage*
D010879:Piperazines; D014750:Vincristine; D011447:Prospidium; D003520:Cyclophosphamide; D011239:Prednisolone
Primenenie prospidina v kombinirovannoĭ khimioterapii retsidivov generalizovannykh form limfogranulematoza.