Cocaine-induced rotation: sex-dependent differences between left- and right-sided rats.
Cocaine elicited dose-related rotation (circling) in naïve rats. The maximum effect was greater than observed previously with other drugs. Overall, females were more sensitive to cocaine than males. However, right-biased females were more sensitive than left-biased females, whereas left-biased males were more sensitive than right-biased males. The results suggest that sex-dependent differences in brain asymmetry may be an important determinant of cocaine sensitivity.
D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology; D005260:Female; D007839:Functional Laterality; D008297:Male; D009068:Movement / Q000187:drug effects*; D051381:Rats; D012399:Rotation; D012737:Sex Factors
D003042:Cocaine; D003913:Dextroamphetamine