title: [Clinical effect and histopathologic observation of malignant melanoma by intratumoral administration of HuIFN- beta].
abstract: 16 patients with skin metastases of malignant melanoma were treated by intratumoral administration of human fibroblast interferon (Hu IFN-beta), with remarkably gratifying results. Generally, the antitumor effect became evident early in the course of treatment. Of particular interest are the histopathologic findings in the malignant lesions. In response to intratumoral injection of Hu IFN-beta, a strikingly large number of lymphocytes emerged to surround and infiltrate into the tumor, not only causing dissociation of its architecture but often surrounding the tumor cells. After a few intratumoral doses, the tumor cells were completely replaced by an abundance of lymphocytes with subsequent emergence of macrophages. These reactions were suggestive of lymphocyte cytotoxicity of killer T cells. By transmission and scanning electron microscopy, the same finding as light microscopy are observed.
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*
chemical_list: D007370:Interferon Type I