[Gangliosides of pig and human thymuses].
The ganglioside composition of thymuses from pigs of different age, of embryonal human thymus and of thymus from newborns was studied. Pig thymus was found to contain 8 ganglioside fractions, i. e. N-acetyl- and N-glycoloylneuraminosyllactosylceramides (GM3), N-acetyl- and N-glycoloylneuraminosylgangliotetraosylceramides (GM1), (N-acetylneuraminosyl, N-glycoloylneuraminosyl)- and di(N-glycoloylneuraminosyl)lactosylceramides (GD3), N-glycoloylneuraminosylgangliotriaosylceramide (GM2) and a fucoganglioside. The ganglioside spectrum of pig thymus did not change with ageing. In embryonal human thymus and in thymus of newborns four ganglioside fractions were determined, i.e. GM3, N-acetylneuraminosylneolactotetraosylceramide GM2 and GD3. A comparison of the experimental results with literature data suggests that ganglioside GD3 is a marker of immature lymphoid cells displaying a marked phylogenetic stability.
D000375:Aging; D000818:Animals; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D004622:Embryo, Mammalian; D005260:Female; D005732:Gangliosides / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D013045:Species Specificity; D013329:Structure-Activity Relationship; D013552:Swine; D013950:Thymus Gland / Q000196:embryology / Q000254:growth & development*
D005732:Gangliosides
Gangliozidy timusa svin'i i cheloveka.