Long-term observations on the effect of polyadenylic acid in mice of different ages.
In order to better life performance, polyadenylic acid (poly (A) ) was given intraperitoneally to CBA/Ca mice for almost a two-year period. This substance, as one of the components of double-stranded polynucleotides (like poly A:U), is known to improve some immune responses of the aging organism. Five approaches (changes in body-weight, adaptation to cold stress, biological half-life of body proteins, mortality and pathology) were applied to test the effects of this substance on life performance. It was found that the beneficial effects of double-stranded polynucleotides cannot be mimicked by polyadenylic acid only, despite its anti-senescence effect, namely, it accelerates the apparent protein turnover, cf., biological half-life. Polyadenylic acid shortens life-expectancy (because of the higher mortality rate of mice). Possible mechanisms of these actions are discussed.
D000375:Aging / Q000187:drug effects*; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D008136:Longevity / Q000187:drug effects; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011061:Poly A / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism
D011506:Proteins; D011061:Poly A