title: Heterocyclic oxyacetic acid diuretics: indazole, benzisothiazole, and benzisothiazole 1,1-dioxide analogues of [[7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy]acetic acid.
abstract: The indazole, benzisothiazole, and benzisothiazole 1,1-dioxide analogues of [[7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy]acetic acid were synthesized and tested for diuretic activity in saline-loaded mice. Each analogue was found to be less active than the parent benzisoxazole: the diuretic activity followed the order O greater than S greater than N = SO2 in regard to the heteroatom in the 1-position of the ring.
mesh_terms: D000818:Animals; D004232:Diuretics / Q000138:chemical synthesis*; D004285:Dogs; D007555:Isoxazoles; D051379:Mice; D009318:Natriuresis / Q000187:drug effects; D010080:Oxazoles / Q000138:chemical synthesis*
chemical_list: D004232:Diuretics; D007555:Isoxazoles; D010080:Oxazoles; C039143:((7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)acetic acid