Comparison of haemodynamic effects of pethidine and anileridine in anaesthetised patients.
Haemodynamic effects of equianalgesic doses of pethidine (1 mk kg -1) and anileridine (0.25 mg kg -1) were compared in patients with coronary artery disease, after induction of anaesthesia with flunitrazepam - N2O - pancuronium. Contrary to previous findings made in conscious patients, these analgesics produced a moderate circulatory depression. Heart rate, cardiac index and rate-pressure product were decreased by both drugs, and anileridine alone decreased mean arterial pressure. The only statistically significant differences in the haemodynamic changes between the two groups were those in pulmonary capillary wedge pressure and rate pressure product, which were slightly lower after anileridine than after pethidine.
D000758:Anesthesia; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003327:Coronary Disease / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007540:Isonipecotic Acids / Q000494:pharmacology*; D008297:Male; D008614:Meperidine / Q000494:pharmacology*; D008875:Middle Aged; D011652:Pulmonary Circulation / Q000187:drug effects; D013997:Time Factors
D007540:Isonipecotic Acids; C100232:anileridine; D008614:Meperidine