title: Chronic methotrexate toxicity to the central nervous system.
mesh_terms: D000328:Adult; D001921:Brain / Q000187:drug effects / Q000473:pathology; D001927:Brain Diseases / Q000139:chemically induced* / Q000473:pathology; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D002648:Child; D006801:Humans; D007275:Injections, Intravenous; D007278:Injections, Spinal; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D009336:Necrosis; D011829:Radiation Dosage; D013577:Syndrome
chemical_list: D008727:Methotrexate