Negative inotropic effects of Na-salicylate and three congeners on the guinea-pig Langendorff heart.
In guinea-pig Langendorff hearts, Na-salicylate (1.9, 3.8 and 7.6 mmol/l) concentration-dependently reduced the contractile force (--9.1, --51.0 and --75.1%, respectively) and the coronary resistance. The influence of the uncoupling agent 2.4-dinitrophenol (0.02 mmol/l) was comparable to that of the largest concentration of Na-salicylate. From the three congeners of Na-salicylate that were tested, only 3.5-diiodosalicylate (0.03 mmol/l) reduced the contractility whereas Na-benzoate (42 mmol/l) and m-iodobenzoate (1.2 mmol/l) were inactive. These results suggest that the cardiac effects of salicylate-like compounds in vitro are caused by an uncoupling of the oxidative phosphorylation.
D019297:2,4-Dinitrophenol; D000818:Animals; D001565:Benzoates / Q000494:pharmacology; D019817:Benzoic Acid; D003864:Depression, Chemical; D004140:Dinitrophenols / Q000494:pharmacology; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007463:Iodobenzoates / Q000494:pharmacology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D010085:Oxidative Phosphorylation; D010477:Perfusion; D012459:Salicylates / Q000494:pharmacology; D012980:Sodium Salicylate / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014475:Uncoupling Agents / Q000494:pharmacology
D001565:Benzoates; D004140:Dinitrophenols; D007463:Iodobenzoates; D012459:Salicylates; D014475:Uncoupling Agents; C020891:3,5-diiodosalicylic acid; C038262:3-iodobenzoic acid; D019817:Benzoic Acid; D019297:2,4-Dinitrophenol; D012980:Sodium Salicylate