Species specificity of immunity to malignant transformed cultured insect cells.
The specificity of malignantly transformed cultured cells of the German cockroach was assayed by injecting the cells into eight additional species of cockroaches in three families. All species but the most advanced one were susceptible. The range of lethal times for the different species reflected their relationship to the species from which the cells originated. The abilities of the injected hosts to encapsulate implants of embryo fragments of the German cockroach and microcarrier beads paralleled their resistance against the malignant cells. The order of susceptibility of the cockroach species to a pathogenic amoeba paralleled their susceptibility to the malignant cells, but death from the amoeba occurred in a much shorter time. Hematocrit values were higher in the more resistant species.
D000562:Amebiasis / Q000276:immunology / Q000662:veterinary; D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003058:Cockroaches / Q000276:immunology* / Q000469:parasitology; D006400:Hematocrit; D013045:Species Specificity