Chronic exposure of rats to enflurane 200 p.p.m.: no evidence of toxicity or teratogenicity.
Adult male or female rats were exposed either to enflurane 200 p.p.m. or to air for up to 63 days before mating and subsequently throughout the pregnancy of the females. The treated animals were exposed for 8 h per day, 5 days per week for a maximum total of 100 days. The parents and progeny-were studied. Additional positive controls with vitamin A palmitate demonstrated that the strain of animals was susceptible to a known teratogen. No abortifacient effect was observed with these conditions of exposure to enflurane. Skeletal examination of the fetuses failed to reveal any major teratogenic effect. The parents remained healthy clinically, whilst autopsy and histopathological examination failed to reveal any consistent organ injuries which could be blamed on exposure to enflurane. In rats at least, environmental pollution with enflurane appears not to be associated with significant toxicity or teratogenicity.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D001842:Bone and Bones / Q000002:abnormalities; D004737:Enflurane / Q000633:toxicity*; D005260:Female; D008297:Male; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D011919:Rats, Inbred Strains
D004737:Enflurane