Effects of FPL-55712 or indomethacin on leukotriene-induced coronary constriction in the intact pig heart.
Intracoronary leukotriene D4, 0.1-3.0 micrograms (0.2-6.0 nmol), produced dose-dependent decreases in coronary flow of anesthetized pigs. Pretreatment with intracoronary FPL-55712 (0.1, 0.3 and 1.0 mg) reduced coronary constriction due to 1.0 micrograms leukotriene D4 by up to 77%. FPL-55712 did not produce sustained alterations in coronary flow, left ventricular end-diastolic pressure, systemic arterial pressure, or heart rate. Indomethacin pretreatment (6 mg/kg i.v.) had no effect on leukotriene-induced coronary constriction. Inhibition produced by FPL-55712 may be useful in disease states involving leukotriene-mediated coronary constriction.
D000818:Animals; D002867:Chromones / Q000494:pharmacology*; D003331:Coronary Vessels / Q000187:drug effects*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D013189:SRS-A / Q000037:antagonists & inhibitors*; D013552:Swine; D014661:Vasoconstriction / Q000187:drug effects*
D002867:Chromones; D013189:SRS-A; C006312:FPL 55712; D007213:Indomethacin