title: Early weight gain and behavioral responsivity as predictors of dietary obesity in rats.
abstract: Variance in diet-induced weight gain was examined for possible relationships with variations in early weight gain and three tests of behavioral responsivity. Female Sprague-Dawley rats were reared in litters of 4, 8, or 20. When animals reached adulthood, each animal's acoustic startle reflex, tail-pinch feeding responses and activity in an open field containing a palatable food were assessed. After completing these behavioral tests, rats were exposed to either palatable foods or a control diet for 59 days, following which all subjects were maintained on the control diet for 66 days. Body weights, food intakes, and naso-anal lengths were measured. Preweaning body weight gain for all rats correlated positively with later diet-induced weight gain. Rats reared in litters of 4 or 20 both gained less weight after exposure to palatable foods than did rats reared in litters of 8. Diet-induced weight gain correlated positively with magnitude of acoustic startle reflex and with latency to eat in response to tail pinch. These results tentatively identify specific predictive factors which may be useful in future studies of dietary obesity.
mesh_terms: D000375:Aging; D000818:Animals; D001143:Arousal; D001835:Body Weight; D004435:Eating; D005106:Exploratory Behavior; D005260:Female; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013216:Reflex, Startle; D013649:Taste