title: New antibiotic, isohematinic acid. I. Taxonomy of producing organism, fermentation and isolation.
abstract: New antibiotic, isohematinic acid, was found in the culture broth of an actinomycete strain SANK 61681, which was identified as a strain of Actinoplanes philippinesis. Fermentation of isohematinic acid was performed by conventional submerged culture in a 600-liter fermentor. Isolation of isohematinic acid was performed by adsorption of the antibiotic from the culture filtrate on a column of Diaion HP-20 followed by elution with aqueous acetone and extraction with ethyl acetate. Isohematinic acid was finally crystallized from hot methanol.
mesh_terms: D000192:Actinomycetales / Q000145:classification / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D005285:Fermentation; D013388:Succinimides / Q000096:biosynthesis
chemical_list: D000900:Anti-Bacterial Agents; D013388:Succinimides; C038713:isohematinic acid