[Effect of removal of the olfactory bulbs on the estrous cycle of the mouse].
The effects of removal of the olfactory bulbs on the estrous cycle and the weight of reproductive organs were examined in mice of the IVCS, ICR and C57BL/6 strains. Sham-operated and intact mice served as controls. Virgin female mice were surgically deprived of the olfactory bulbs at 8 weeks of age and caged individually in air-conditioned rooms with controlled lighting (14 hours of light, from 5 a. m. to 7 p. m., each day). Vaginal smears were observed daily. The animals were killed and their principal organs weighed at 6 weeks after the operation. The results obtained were as follows; 1) The olfactory bulb ablation prolonged the length of estrous cycle of mice of the ICR (6.0 days) and C57BL/6 (5.0 days) strains, but did not modify the cycle in those of the IVCS strain (4.0 days). 2) A decrease of ovarian weights by this operation was observed in the mice of the IVCS and ICR strains, but not C57BL/6 strain.
D000818:Animals; D000830:Animals, Laboratory / Q000502:physiology; D001835:Body Weight; D004326:Drinking; D004435:Eating; D004971:Estrus; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains / Q000502:physiology*; D009830:Olfactory Bulb / Q000502:physiology*; D009929:Organ Size; D010053:Ovary / Q000033:anatomy & histology; D010060:Ovulation; D011247:Pregnancy; D014599:Uterus / Q000033:anatomy & histology; D014626:Vaginal Smears