Anticonvulsant effects of stress: role of endogenous opioids.
Mice subjected to immobilization stress were protected against electrconvulsive shock-induced seizures in comparison to non-stressed mice. Pretreatment with naltrexone antagonized the effects of stress indicating that the protective effects of stress on seizures involved a release of endogenous opioids.
D000818:Animals; D000927:Anticonvulsants; D004723:Endorphins / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009271:Naltrexone / Q000494:pharmacology; D012149:Restraint, Physical; D012640:Seizures / Q000209:etiology / Q000503:physiopathology; D013312:Stress, Physiological / Q000503:physiopathology*
D000927:Anticonvulsants; D004723:Endorphins; D009271:Naltrexone