Lymphomatoid papulosis. Case report providing evidence for a monocyte-macrophage origin of the atypical cells.
A patient with "classical" lymphomatoid papulosis is described in whom self-healing tumorous lesions occurred. Histologic, immunologic, enzyme histochemical and ultrastructural studies were performed. The atypical cells were found to be of monocyte-macrophage origin. The infiltrate also contained a variable number of suppressor-cytotoxic T-lymphocytes, depending on the stage of the tumorous lesions. The number of IgA positive B-lymphocytes in the peripheral blood was increased. The findings indicate that "classical" lymphomatoid papulosis is not a cutaneous T-cell lymphoma, but is the expression of an abnormal, immune reaction in the skin.
D000328:Adult; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis; D006801:Humans; D008223:Lymphoma / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D008264:Macrophages / Q000166:cytology*; D008297:Male; D008854:Microscopy, Electron; D009000:Monocytes / Q000166:cytology*; D009365:Neoplasm Regression, Spontaneous; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm