Determination of lidocaine concentrations producing therapeutic and toxic effects in dogs.
Lidocaine was infused at a fixed zero-order rate to eight healthy mongrel dogs until tonic extension (n = 5) and cortical seizures (n = 7) were produced. Lidocaine concentrations determined at 5-min intervals were used to calculate concentrations at which these effects occurred. The tonic extension phase occurred at a mean lidocaine concentration of 8.21 +/- 1.69 micrograms/ml. After a 1-month rest period, the same dogs were anaesthetized and ventricular tachycardia was produced by administering ouabain. Lidocaine was again infused at a fixed zero-order rate until all beats of ventricular origin were abolished. This occurred at a mean lidocaine concentration of 6.25 +/- 1.49 micrograms/ml.
D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D008012:Lidocaine / Q000097:blood* / Q000627:therapeutic use / Q000633:toxicity; D008297:Male; D013610:Tachycardia / Q000188:drug therapy / Q000662:veterinary
D008012:Lidocaine