title: [Comparison of bumadizone-, phenylbutazone- and oxyphenbutazone-plasma levels after a single oral dose of phenylbutazone and of bumadizone, respectively (author's transl)].
abstract: Bumadizone-calcium-semihydrate and phenylbutazone were given orally to two groups (I and II) consisting of 6 persons each; plasma levels of bumadizone, phenylbutazone and oxyphenbutazone were determined over a period of 384 h. For bumadizone a plasma half-life of 6.9 h was found, maximum plasma levels were reached after 1-6 h varying from 27 to 46 microgram/ml. Phenylbutazone- and oxyphenbutazone-AUC-values were compared between the two groups.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008314:Malonates / Q000008:administration & dosage / Q000097:blood*; D008875:Middle Aged; D010113:Oxyphenbutazone / Q000097:blood*; D010653:Phenylbutazone / Q000008:administration & dosage / Q000097:blood*
chemical_list: D008314:Malonates; C100233:bumadizone; D010653:Phenylbutazone; D010113:Oxyphenbutazone
vernacular_title: Vergleichende Untersuchung der Bumadizon-, Phenylbutazon- und Oxyphenbutazon-Plasmaspiegel nach einmaliger Gabe von Phenylbutazon und von Bumadizon.