Vasculitis in Goodpasture's syndrome.
Because of differing diagnostic criteria, a controversy exists as to whether vasculitis may occur in patients with Goodpasture's syndrome. Using strict criteria (pulmonary hemorrhage, glomerulonephritis, and antiglomerular basement membrane antibody), we found histological evidence of vasculitis in two of 18 patients with Goodpasture's syndrome. The vasculitis was found in kidney biopsy specimens. Clinically, these two patients did not differ from other patients who have Goodpasture's syndrome without vasculitis. The presence of vasculitis should not exclude the diagnosis of Goodpasture's syndrome.
D000293:Adolescent; D000368:Aged; D019867:Anti-Glomerular Basement Membrane Disease / Q000150:complications* / Q000276:immunology; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D014657:Vasculitis / Q000209:etiology* / Q000473:pathology