Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization.
A strain of Streptomyces was found to produce new antifungal antibiotics. The active compounds were purified and separated into two substances named leptomycin A and B by high performance liquid chromatography. The molecular formulae of leptomycins A and B are C32H46O6 and C33H48O6 respectively, and physicochemical and biological properties of them are very similar to each other. Leptomycins A and B exhibit strong inhibitory activity against Schizosaccharomyces and Mucor.
D000935:Antifungal Agents / Q000302:isolation & purification*; D001419:Bacteria / Q000145:classification* / Q000648:ultrastructure; D004353:Drug Evaluation, Preclinical; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009089:Mucor / Q000187:drug effects; D012568:Schizosaccharomyces / Q000187:drug effects; D012988:Soil Microbiology; D013055:Spectrophotometry, Infrared; D013171:Spores, Bacterial / Q000648:ultrastructure
D000935:Antifungal Agents; D005231:Fatty Acids, Unsaturated; C038752:leptomycin A; C038753:leptomycin B