A calcium-activated nuclease endogenous to Xenopus erythrocytes.
An endogenous nuclease is found in purified Xenopus erythrocyte nuclei. This enzyme is activated specifically by Ca2+ in the presence of which chromatin is digested into discrete fragments. Both 10 bp and 200 bp ladders are detected upon electrophoresis of DNA. This endogenous enzyme therefore resembles mammalian and chicken liver endonucleases.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D003851:Deoxyribonucleases / Q000097:blood*; D004789:Enzyme Activation / Q000187:drug effects; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D014981:Xenopus
D003851:Deoxyribonucleases; D002118:Calcium