Results of a randomized double-blind crossover trial of scopolamine versus placebo administered by transdermal patch for the control of cisplatin-induced emesis.
We tested the efficacy of scopolamine delivered by transdermal patch in preventing emesis induced by cisplatin as a single agent or in combination. The administration of scopolamine by transdermal patch resulted in acceptable side effects but was ineffective in controlling cisplatin-induced emesis.
D000328:Adult; D002945:Cisplatin / Q000009:adverse effects*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy; D010919:Placebos; D012601:Scopolamine / Q000008:administration & dosage / Q000627:therapeutic use*; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
D010919:Placebos; D012601:Scopolamine; D002945:Cisplatin