[Value of a kinetic study of intraerythrocyte lithium in research on bioclinical correlations in intolerant subjects].
From the plasma and red cell kinetics of lithium in 43 patients having received lithium therapy for at least 15 days, the authors try to establish a correlation between intolerance and a variety of parameters examined. Statistical analysis reveals that: intra-erythrocytic concentration is a more reliable biological index than the lithium level; it can be modified by associated drug therapy; measuring the erythroplasmic ratio at different times of the day shows important variation within individuals. This type of kinetic study can identify biologically the 2 sub-groups distinguished by clinical examination: tolerant subjects (those on lithium therapy without any neurological signs) and poorly tolerant subjects.
D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy*; D002940:Circadian Rhythm; D004359:Drug Therapy, Combination; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008094:Lithium / Q000009:adverse effects / Q000097:blood*
D008094:Lithium
Intérêt de l'étude cinétique du lithium intraérythrocytaire dans la recherche de corrélations biocliniques chez les sujets intolérants.