Dermorphin: effects on anterior pituitary function in the rat.
Dermorphin is an exceptionally potent opioid peptide from amphibian skin. Intravenous injection of dermorphin in pharmacological doses did not affect prolactin and growth hormone release or serum glucose. In contrast, dermorphin significantly stimulated TSH secretion and significantly suppressed LH secretion. These results suggest that dermorphin has selective effects on anterior pituitary function in mammals.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism; D007275:Injections, Intravenous; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D009294:Narcotics / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D018847:Opioid Peptides; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000502:physiology*; D011388:Prolactin / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344; D013972:Thyrotropin / Q000378:metabolism
D001786:Blood Glucose; D009294:Narcotics; D009842:Oligopeptides; D018847:Opioid Peptides; C030058:dermorphin; D011388:Prolactin; D007986:Luteinizing Hormone; D013972:Thyrotropin; D013006:Growth Hormone