A quantitative histochemical study of glucose-6-phosphate dehydrogenase activity in premalignant and malignant lesions of human oral mucosa.
The levels of glucose-6-phosphate dehydrogenase activity have been assayed by quantitative histochemistry in normal, benign, potentially malignant and carcinomatous lesions of human oral mucosa. Dysplastic epithelium showed a higher activity of this enzyme than did morphologically normal, benign hyperplastic and neoplastic lesions and this may be an aid to early diagnosis. The increases in glucose-6-phosphate dehydrogenase activity in dysplastic human oral epithelium are sufficient to warrant a longitudinal study to evaluate further the significance of these changes in the process of malignant transformation.
D004848:Epithelium / Q000201:enzymology; D005260:Female; D005350:Fibroma / Q000175:diagnosis / Q000201:enzymology*; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D009059:Mouth Diseases / Q000175:diagnosis; D009061:Mouth Mucosa / Q000201:enzymology*; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000201:enzymology*; D011230:Precancerous Conditions / Q000201:enzymology*