Studies on the retention of passively transferred antibodies in man. II. Antibody activity in the blood after intravenous or intramuscular administration of anti-HBs human immunoglobulin.
Catabolism of intravenously or intramuscularly administered human immunoglobulin in man was studied by the administration of HBs antibodies at a high titer and analysis with a highly sensitive radioimmunoassay technique. The half-life in the blood of the antibodies in the aggregate-reduced antibody preparation administered intravenously was found to be 17.7 days and of those in the antibody preparation administered intramuscularly to be 23.8 days.
D000328:Adult; D000914:Antibodies, Viral / Q000008:administration & dosage*; D006207:Half-Life; D006510:Hepatitis B Antibodies / Q000008:administration & dosage* / Q000032:analysis; D006801:Humans; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000008:administration & dosage* / Q000032:analysis / Q000378:metabolism; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male
D000914:Antibodies, Viral; D006510:Hepatitis B Antibodies; D007074:Immunoglobulin G