Effects of chemicals on delayed matching behavior in pigeons. II: tolerance to the effects of diazepam and cross tolerance to phencyclidine.
Pigeons were trained under a 2-sec matching to sample schedule. Diazepam, phencyclidine and pentobarbital all decreased matching accuracy. Chronic administration of diazepam after the session produced no effect on matching accuracy on the next day; however, two weeks of postsession diazepam administration produced tolerance to the effects of presession diazepam administration and cross tolerance to phencyclidine, but not to pentobarbital. After 6 weeks without chronic diazepam administration, both the tolerance to the effects of diazepam on matching accuracy and the cross tolerance to phencyclidine had disappeared.
D000818:Animals; D010856:Columbidae; D003975:Diazepam / Q000494:pharmacology*; D004361:Drug Tolerance; D007858:Learning / Q000187:drug effects*; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D010622:Phencyclidine / Q000494:pharmacology*
D010424:Pentobarbital; D010622:Phencyclidine; D003975:Diazepam