[Changes in estriol excretion in the urine and kidney function during Partusisten infusion].
In a random controlled trial the effects of a betamimetic infusion (Fenoterol 2 micrograms/min) on the estriol excretion and the renal function were analysed in 30 patients in the 28.-34. weeks of pregnancy. It was stated that the estriol excretion in urine during the Partusisten infusion significant decreases (from 663 micrograms/2 h to 376 micrograms/2 h, i.e. to 56%). The diuresis and the creatinine-clearance showed a significant diminishing too (from 218 ml/2 h to 154 ml/2 h and from 131 ml/min to 88 ml/min). The decrease of estriol excretion is caused on the one hand by the diminution of GFR, on the other by a direct effect of betamimetics on the kidney. From the results obtained in this study the following consequences can be drawn: 1. The determination of urinary estriol during tocolytic treatment is not a suitable method for the monitoring the fetoplacental unit. 2. Applying the tocolysis in an infusion a possible reduction of water intake and a strict control of water balance is of great importance. 3. The betamimetic therapy in patients having an impaired renal function can be applied only with great precaution.
D003404:Creatinine / Q000097:blood; D004964:Estriol / Q000652:urine*; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D005280:Fenoterol / Q000627:therapeutic use*; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D007752:Obstetric Labor, Premature / Q000517:prevention & control* / Q000652:urine; D011247:Pregnancy; D014590:Uterine Contraction / Q000187:drug effects; D014882:Water-Electrolyte Balance / Q000187:drug effects
D004983:Ethanolamines; D005280:Fenoterol; D003404:Creatinine; D004964:Estriol
Die Veränderungen der Ostriolausscheidung im Harn und der Nierenfunktion während Partusisten-Infusion.