title: [Age-related changes in the immune response of (CBA X C57BL)F1 hybrid mice. I. Stimulation of antibody formation in old animals].
abstract: A study of immune response to sheep erythrocytes in CBA X C57BL F1 hybrids of different age has shown a sharp fall in the number of antibody forming cells in the spleen of old mice. An analysis of data on stimulatory effect of preliminary sublethal irradiation and introduction of hydrocortisone upon antibody formation in old mice allows to conclude that cells-regulators inhibiting the antibody forming cells are accumulated in the spleen of old animals. These cells are sensitive to ionizing irradiation and hydrocortisone.
mesh_terms: D000375:Aging / Q000187:drug effects / Q000528:radiation effects; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects / Q000528:radiation effects; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000528:radiation effects; D003433:Crosses, Genetic; D004912:Erythrocytes / Q000276:immunology; D006854:Hydrocortisone / Q000276:immunology; D007114:Immunization; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology*; D008808:Mice, Inbred CBA / Q000276:immunology*; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000276:immunology
chemical_list: D006854:Hydrocortisone
vernacular_title: Vozrastnye izmeneniia v immunnom otvete mysheĭ (CBA X C57BL)F1--gibridov. I. Stimuliatsiia antitelogeneza u starykh zhivotnykh.