Presence of 3-amino-beta-carbolines (3-amino-9H-pyrido[3,4-b]indoles), effectors in the induction of sister-chromatid exchanges, in protein pyrolysates.
3-Amino-9H-pyrido[3,4-b]indole (3-aminonorharman) and 3-amino-1-methyl-9H-pyrido[3,4-b]indole (3-aminoharman), effectors for induction of sister-chromatid exchanges in human lymphoblastoid cells, were identified in pyrolysates of casein by high-performance liquid chromatography and UV spectrophotometry, together with some other mutagenic/carcinogenic carbolines. In pyrolysates from a preparation of zein, which contained little tryptophan, only norharman and harman were found in small amounts.
D000818:Animals; D002243:Carbolines / Q000302:isolation & purification / Q000633:toxicity*; D002364:Caseins; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D003434:Crossing Over, Genetic; D005260:Female; D006358:Hot Temperature; D006801:Humans; D007211:Indoles / Q000633:toxicity*; D008214:Lymphocytes; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D010053:Ovary; D011506:Proteins; D012854:Sister Chromatid Exchange; D013329:Structure-Activity Relationship
D002243:Carbolines; D002364:Caseins; D007211:Indoles; D009153:Mutagens; D011506:Proteins; C038742:3-aminonorharman; C038743:3-aminoharman