Hepatic and intestinal 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in genetically diabetic mice.
Cholesterol synthesis rate, as determined by 3-hydroxy-3-methylglutaryl coenzyme A reductase activity, is characterized in the major organs of genetically diabetic mice. Both C57BL/Ks db+/db+ and C57BL/6 ob+/ob+ mice are hyperinsulinemic and insulin-resistant. These animals demonstrate loss of the circadian rhythm of hepatic reductase activity and a tendency for increased intestinal activity. As a result, proportionally more endogenous cholesterol synthesis occurs in intestinal mucosa than liver in genetically diabetic animals. Thus, the alterations in activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase which are observed in animal models of diabetes are the result of diminished insulin effect rather than insulin level.
D000818:Animals; D001835:Body Weight; D003920:Diabetes Mellitus / Q000201:enzymology* / Q000235:genetics; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000302:isolation & purification*; D007333:Insulin Resistance; D007422:Intestines / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity
D006903:Hydroxymethylglutaryl CoA Reductases