LTA: a human lung tumor-associated antigen common to primary lung tumors and cultured lung tumor cell lines.
A human lung tumor-associated antigen (LTA) previously purified from a primary lung tumor has been identified in the sera of lung cancer patients. Frequencies of LTA elevations in lung cancer were: adenocarcinoma, 60%; squamous cell carcinoma, 42%; large cell carcinoma, 17%; and small cell carcinoma, 19%; normals, 2%; benign lung disease, 0%; and non-lung malignancies, 13%. The antigen was also shown to be produced by seven of the eight human lung tumor cell lines that were examined. A preliminary small-scale purification was attempted on an extract from one of these lines, ChaGo, which yielded a smaller and more basic form of LTA but which possessed similar, if not identical, antigenic activities as primary tumor LTA.
D000951:Antigens, Neoplasm / Q000032:analysis*; D002460:Cell Line; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology*
D000951:Antigens, Neoplasm