Experimental venous thrombosis in rats treated with heparin and a low molecular weight heparin fraction.
An unfractionated mucosal heparin preparation and a low molecular weight heparin fraction were randomly administered to rats subcutaneously. This injection was made on rats with experimentally induced venous thrombosis. At high doses (6.66 mg/kg) of both drugs, thrombus mean weight was reduced in comparison with a control group. At lower doses (2.22 mg/kg) these two drugs inhibited the growth of the thrombus. This inhibition was obtained with a lower dose (0.66 mg/kg) of the low molecular weight heparin fraction than of heparin. The low molecular weight heparin fraction (molecular weight 5,000 daltons) has a high anti-Xa activity (200 units) and a low activity determined by the USP assay (50 units).
D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006493:Heparin / Q000008:administration & dosage*; D007273:Injections, Intramuscular; D008297:Male; D008970:Molecular Weight; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D013924:Thrombophlebitis / Q000188:drug therapy*
D006493:Heparin