Conversion in vitro of urinary (+)-penicillamine to its major metabolites, PSSP and PSSC.
To investigate the discrepancy between the apparent pharmacokinetic disposition of (+)-penicillamine in plasma and urine, the spontaneous degradation of (+)-penicillamine was studied in acidified and non-acidified urine. Degradation was prevented by acidification. The oxidized metabolites were converted to reduced (+)-penicillamine by electrolysis.
D001711:Biotransformation; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008297:Male; D010396:Penicillamine / Q000652:urine*; D013997:Time Factors
D010396:Penicillamine