Activation of the alternative pathway of complement by Malassezia ovalis (Pityrosporum ovale).
Activation of C3 and factor B in normal human serum by P. ovale was demonstrated using a standard unidirectional immunoelectrophoresis technique. Activation of complement by the alternative (properdin) pathway is a possible mechanism by which P. ovale may mediate an inflammatory response.
D003167:Complement Activation; D003176:Complement C3 / Q000378:metabolism; D003179:Complement C3b / Q000378:metabolism; D011415:Complement Factor B / Q000378:metabolism; D003170:Complement Pathway, Alternative; D006801:Humans; D007122:Immunoelectrophoresis; D008290:Malassezia / Q000276:immunology*
D003176:Complement C3; D003179:Complement C3b; D011415:Complement Factor B