title: [Brain monoamines and their metabolites in Vistar and Krushinskiĭ-Molodkina strain rats].
abstract: The results of the studies devoted to defining the content of biogenic monoamines and their metabolites in different parts of cerebrum in rats of two inbred Vistar and Krushinsky--Molodkina lines are presented. It is proved that the intact rats of Krushinsky--Molodkina line differ from Vistar rats in the higher contents of adrenaline and dopamine of the hypothalamus and striatum, of serotonin in the hypothalamus. Also, the tendency to lowering noradrenaline in the hypothalamus and striatum, as well as the higher activity of the pathways of oxidative desamination and O-methylation in the hypothalamus was shown. The pronounced shift in the level of monoamines and its metabolism has been observed under the influence of immobilization in Vistar rats. At the same time, none of the neurochemical parameters are altered in the rats of Krushinsky--Molodkina line. The results obtained are regarded from the point of view of genetically determined balance of activating and inactivating influence differing in various lines.
mesh_terms: D000818:Animals; D001679:Biogenic Amines / Q000032:analysis / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D003342:Corpus Striatum / Q000378:metabolism; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains / Q000378:metabolism*; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism; D013997:Time Factors
chemical_list: D001679:Biogenic Amines
vernacular_title: Monoaminy mozga i ikh metabolity u krys liniĭ Vistar i Krushinskogo-Molodkinoĭ.