Effect of postnatal hypoxia on the energy homeostasis of the newborn rat during the early neonatal period.
Newborn rats breathing a low-oxygen mixture showed similar rates of glycogenolysis to newborns breathing air. However, hypoxia prevented the decrease of plasma glucose and lactate concentrations which occurred in newborns breathing air immediately after delivery. The time-course of plasma alanine was not affected by experimental hypoxia. The decrease in the liver lactate/pyruvate ratio observed in control newborns immediately after delivery was prevented by hypoxia. Lower blood oxygen concentrations were observed in hypoxic animals throughout the observation period. Lower ATP concentrations were observed in hypoxic newborns during the first hour after delivery but similar values were observed in both groups thereafter.
D000227:Adenine Nucleotides / Q000378:metabolism; D000409:Alanine / Q000097:blood; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D004734:Energy Metabolism; D005934:Glucagon / Q000378:metabolism; D006706:Homeostasis; D000860:Hypoxia / Q000097:blood / Q000378:metabolism*; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008099:Liver / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D010100:Oxygen / Q000097:blood; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D051381:Rats; D011919:Rats, Inbred Strains
D000227:Adenine Nucleotides; D001786:Blood Glucose; D007773:Lactates; D008112:Liver Glycogen; D011773:Pyruvates; D019344:Lactic Acid; D019289:Pyruvic Acid; D005934:Glucagon; D000409:Alanine; D010100:Oxygen