The relationship of growth hormone to 1,25-dihydroxyvitamin D3 in intestinal calcium transport.
The effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and bovine growth hormone (bGH) on intestinal calcium transport have been assessed in vitamin D deficient rats. Calcium transport did not increase after 7 days bGH treatment. A single dose of 1,25(OH)2D3 significantly increased calcium transport in the hypophysectomized (Hx) rats treated with bGH but not in the Hx rats who did not receive bGH, unless the dosage of 2,25(OH)2D3 was increased to 500 p moles. Even though calcium transport in the Hx rats was stimulated by the high dose of 1,25(OH)2D3, this response was less in the Hx than in bGh treated group. These results suggest that growth hormone status may be important in the expression of 1,25-(OH)2D3 action on intestinal calcium transport.
D000818:Animals; D002117:Calcitriol; D002118:Calcium / Q000378:metabolism*; D004100:Dihydroxycholecalciferols / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D013006:Growth Hormone / Q000494:pharmacology*; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D007016:Hypophysectomy; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D051381:Rats; D014808:Vitamin D Deficiency / Q000378:metabolism
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D013006:Growth Hormone; D002117:Calcitriol; D002118:Calcium