[Dose-dependent cardiodepression in acute alcohol intoxication in the rat].
Isovolumetric pressure-volume relations, parameters of contractility and the resting tension curve were recorded in Wistar rats prior and during acute intoxication with ethylalcohol. Parameters were recorded at blood levels between 6.0% and 2.0% of the intravenously infused alcohol. At the high blood alcohol level, maximal isovolumetric pressure is diminished by 24%, maximal rate of pressure rise by 42%, as compared with controls, whereas enddiastolic pressure increased by 32% and enddiastolic volume by 11%. Significant impairment of hemodynamics is also present at a blood alcohol level of 2.0%. These findings point to a dose-dependent cardiodepression in acute alcohol intoxication.
D000435:Alcoholic Intoxication / Q000209:etiology* / Q000503:physiopathology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D000431:Ethanol / Q000097:blood / Q000633:toxicity*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol
Dosisabhängige Kardiodepression bei der akuten Alkoholintoxikation der Ratte.