Effects of cicloxilic acid on bile flow and lipid composition in rats with ethinylestradiol-induced cholestasis.
A subacute dose of ethinylestradiol reduces the bile flow and the bile salt:cholesterol and bile salt + lecithin:cholesterol molar ratios in the rat. An acute dose of cis-2-hydroxy-2-phenyl-cyclohexanecarboxylic acid (cicloxilic acid) 50 mg kg-1 i.v. normalizes these parameters. These findings confirm and extend similar data in laboratory animals and in clinical trials.
D000818:Animals; D001646:Bile / Q000187:drug effects* / Q000378:metabolism; D002756:Cholagogues and Choleretics; D002779:Cholestasis / Q000139:chemically induced / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000037:antagonists & inhibitors*; D050356:Lipid Metabolism; D008297:Male; D010713:Phosphatidylcholines / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D002756:Cholagogues and Choleretics; D003509:Cyclohexanecarboxylic Acids; D010713:Phosphatidylcholines; C018873:cicloxilic acid; D004997:Ethinyl Estradiol; D002784:Cholesterol