[Selective inhibition of pyruvate dehydrogenase in the liver and heart of mice by triphosphate esters of thiochrome and tetrahydrothiamine].
In experiments with white mice it was shown that in contrast to hydroxythiamine and other known vitamin B1 antagonists, triphosphate esters of thiochrome and tetrahydrothiamine possess a selective anticoenzyme activity with respect to the only one of the thiamine pyrophosphate-dependent enzymes, i.e. pyruvate dehydrogenase.
D000818:Animals; D004951:Esterification; D005260:Female; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D051379:Mice; D009206:Myocardium / Q000201:enzymology*; D011743:Pyrimidines / Q000494:pharmacology*; D011768:Pyruvate Dehydrogenase Complex / Q000037:antagonists & inhibitors*; D013831:Thiamine / Q000031:analogs & derivatives*; D013835:Thiamine Pyrophosphate / Q000031:analogs & derivatives* / Q000494:pharmacology; D014174:Transketolase / Q000097:blood
D011743:Pyrimidines; D011768:Pyruvate Dehydrogenase Complex; C037342:tetrahydrothiamine pyrophosphate; C005793:thiochrome; D014174:Transketolase; D013835:Thiamine Pyrophosphate; D013831:Thiamine
Izbiratel'noe ingibirovanie piruvatdegidrogenazy pecheni i serdtsa mysheĭ trifosfornymi éfirami tiokhroma i tetragidrotiamina.