Lonomycins B and C, two new components of polyether antibiotics. Fermentation, isolation and characterization.
Lonomycin B (II), C44H75O14Na, m.p. 181-182 degrees C, and lonomycin C (III), C43H73O14Na, m.p 186-187 degrees C, were isolated as their sodium salts from the fermentation broth of Streptomyces ribosidificus TM-481. Their physicochemical properties demonstrated that II and III are closely related congeners of lonomycin A (I). The identical mass spectra of methyl esters of I and II indicated that II is a stereoisomer of I. On the other hand, the mass spectrum of a methyl ester of III showed a peak at m/e 810 due to M+-H2O which is smaller by 14 mass units than the maximum peak at m/e 824 due to M+-H2O of the methyl esters of I and II. This result together with the elemental analysis strongly suggested that III is a demethyl derivative of I or II. II and III are slightly less active than I in their antimicrobial activities.
D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003470:Culture Media / Q000032:analysis; D004352:Drug Resistance, Microbial; D005285:Fermentation; D013058:Mass Spectrometry; D009550:Nigericin / Q000031:analogs & derivatives / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D013302:Streptomyces / Q000378:metabolism*; D000095662:Polyether Polyketides
D000900:Anti-Bacterial Agents; D003470:Culture Media; D009550:Nigericin; C012410:lonomycin; C030868:lonomycin C; D000095662:Polyether Polyketides