Dissolution kinetics of a three-component solid I: ethylparaben, phenacetin, and salicylamide.
The dissolution rates of each component in compressed spheres consisting of three components were measured under sink conditions. A film diffusion model is discussed and presented diagrammatically to illustrate the 13 possible dissolution behaviors of a three-component solid. Experimental dissolution rates compare favorably to dissolution rates calculated according to the model at mass fractions representative of the 13 dissolution behaviors.
D007700:Kinetics; D008956:Models, Chemical; D010226:Parabens; D010615:Phenacetin; D012457:Salicylamides; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
D010226:Parabens; D012457:Salicylamides; C012313:ethyl-p-hydroxybenzoate; C031060:salicylamide; D010615:Phenacetin