Operant control of turning in circles: a new model of dopaminergic drug action.
Rats were trained, using water reinforcement, to exhibit high rates of rotation (circling) during one-hour daily test sessions. Preferred directions of learned rotation were the same as those determined previously in response to D-amphetamine. Changes in reinforcement parameters elicited predictable changes in rates of learned rotation. The effects of D-amphetamine, apomorphine, haloperidol and methohexital could be readily dissociated indicating that the operant rotation paradigm could likely become a useful behavioral assay of dopaminergic drug action.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology*; D003342:Corpus Striatum / Q000502:physiology; D003913:Dextroamphetamine / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008723:Methohexital / Q000494:pharmacology; D008959:Models, Neurological; D009434:Neural Pathways / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects / Q000502:physiology*; D013378:Substantia Nigra / Q000502:physiology
D008723:Methohexital; D006220:Haloperidol; D001058:Apomorphine; D003913:Dextroamphetamine; D004298:Dopamine