Effect of cannabichromene on hepatic microsomal enzyme activity in the mouse.
1. Pretreatment with a Cannabis constituent, cannabichromene (CBC), i.p., had no effect on in vitro hepatic microsomal enzyme activity compared to a known inhibitor of these systems, SKF 525-A. 2. The results indicate that the previously reported CBC potentiation of CNS depressant-induced hypnosis is not mediated by the hepatic microsomal enzyme system.
D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D002186:Cannabinoids / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D011335:Proadifen / Q000494:pharmacology
D002186:Cannabinoids; D011335:Proadifen; D000815:Aniline Hydroxylase; D000633:Aminopyrine N-Demethylase; C010695:cannabichromene