Cytogenetic evidence of clonal evolution in a case of hemopoietic dysplasia with a 5q- chromosome.
A 70-year-old Japanese male with hemopoietic dysplasia is described. Cytogenetic investigation revealed an abnormal karyotype, 46,XY,del(5)(q13q33), in all metaphases examined at the time of diagnosis. Eight months later, a newly appearing abnormal hyperdiploid karyotype, 47,XY,5q-, +21, was observed in 74% of the cells analyzed, which was associated with evolution of the disease when a pathologic diagnosis of a myeloproliferative disorder was made.
D000368:Aged; D001491:Basophils / Q000166:cytology; D001792:Blood Platelets / Q000166:cytology; D001853:Bone Marrow / Q000473:pathology*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002999:Clone Cells; D006402:Hematologic Diseases / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D007082:Ileum / Q000473:pathology; D007621:Karyotyping; D008297:Male; D009504:Neutrophils / Q000166:cytology