Protein C deficiency in a Dutch family with thrombotic disease.
A rabbit antibody against human protein C was used for the quantitative estimation of protein C in plasma. In healthy individuals protein C antigen ranged from 0.65-1.45 U/ml. Plasma protein C antigen was found to be independent of either age or sex. Under influence of oral anticoagulant treatment the protein C antigen concentration decreased to 0.47 U/ml (at low intensity treatment) or 0.33 U/ml (at high intensity treatment). Using normal ranges of protein C and protein C/factor II and protein C/factor X ratios criteria were developed for the assessment of protein C deficiency. In a Dutch family with a history of thrombotic disease two members were found to have an isolated protein C deficiency, while a third one is suspected of protein C deficiency. In one case it was possible to confirm the diagnosis of suspected protein C deficiency during temporary withdrawal of the anticoagulant therapy.
D000328:Adult; D000368:Aged; D000375:Aging; D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use; D001778:Blood Coagulation Disorders / Q000150:complications / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D006023:Glycoproteins / Q000032:analysis / Q000276:immunology; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D011486:Protein C; D011655:Pulmonary Embolism / Q000209:etiology; D011817:Rabbits; D013924:Thrombophlebitis / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*
D000925:Anticoagulants; D006023:Glycoproteins; D007106:Immune Sera; D011486:Protein C