title: Hemoglobin-inulin conjugate as an oxygen carrying blood substitute.
abstract: Pyridoxylated hemoglobin was modified with the activated ester of inulin. From the oxygen equilibrium curve, this conjugate was estimated to have about fivefold oxygen carrying capacity compared with a free hemoglobin. The half disappearance time of this conjugate in the circulation of a rat was 21 hours in contrast to 3 hours of a free hemoglobin. The oncotic pressure and the viscosity can be adjusted nearly equal to those of whole blood. This conjugate can be concluded to have sufficient properties for use as a blood substitute.
mesh_terms: D000818:Animals; D001802:Blood Substitutes; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D006454:Hemoglobins / Q000494:pharmacology*; D007444:Inulin / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood*; D011485:Protein Binding; D051381:Rats
chemical_list: D001802:Blood Substitutes; D006454:Hemoglobins; C038445:pyridoxyl-hemoglobin-inulin; D007444:Inulin; D010100:Oxygen