Age alters dopaminergic responses to estradiol.
Young (3-5 months) and middle-aged (17-19 months) ovariectomized rats were treated with estradiol benzoate for three days and striatal dopaminergic function was assessed behaviorally (circling in response to apomorphine) and neurochemically (binding of [3H]spiroperidol by striatal membranes). The results suggest that striatal dopaminergic function may respond differently to estrogen in older animals compared to younger animals.
D000375:Aging; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001667:Binding, Competitive; D002369:Castration; D003342:Corpus Striatum / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D051381:Rats; D011954:Receptors, Dopamine / Q000502:physiology*; D013134:Spiperone / Q000378:metabolism; D013239:Stereotyped Behavior / Q000187:drug effects
D011954:Receptors, Dopamine; D004958:Estradiol; D013134:Spiperone; D001058:Apomorphine