[Alteration in the phospholipid spectrum of blood serum and the state of hemocoagulation in experimental loading with phospholipids].
Phosphatidyl serine, phosphatidyl choline and sphingomyelin were administered into rats separately and simultaneously (at natural ratios, up to the final concentration exceeding 2-fold the normal level in blood). The phospholipid spectrum was estimated in blood serum by means of thin-layer chromatography and the state of haemocoagulation was monitored by means of autocoagulogramms. Sphingomyelin, reducing the content of some physiologically active phospholipids, did not alter haemocoagulation. Administration of phosphatidyl choline, phosphatidyl serine and mixtures of phospholipids resulted in an increase in blood serum of phosphatidyl serine that was responsible for hypocoagulation effect. The accelerating effect of phosphatidyl choline on phosphatidyl serine and importance of the phosphatidyl choline-phosphatidyl serine complex in haemocoagulation is discussed.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D008297:Male; D010713:Phosphatidylcholines / Q000494:pharmacology; D010718:Phosphatidylserines / Q000494:pharmacology; D010743:Phospholipids / Q000097:blood*; D051381:Rats; D013109:Sphingomyelins / Q000494:pharmacology; D013329:Structure-Activity Relationship
D010713:Phosphatidylcholines; D010718:Phosphatidylserines; D010743:Phospholipids; D013109:Sphingomyelins
Izmenenie fosfolipidnogo spektra syvorotki krovi i sostoianie gemokoaguliatsii pri éksperimental'no sozdavaemom izbytke fosfolipidov.