Possible role of calmodulin in stimulation of hexose transport by 12-O-tetradecanoylphorbol-13-acetate, a tumor promoter.
12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter stimulated the rate of 2-deoxy-D-glucose (2DG) transport. Three different kinds of calmodulin antagonists inhibited the TPA-stimulated 2DG transport, the mechanism of which was examined in kinetic analysis. These results indicate that the expression of the effect of TPA may depend on Ca2+-calmodulin system.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000494:pharmacology*; D002147:Calmodulin / Q000494:pharmacology*; D002642:Chick Embryo; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism; D007700:Kinetics; D010704:Phorbols / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014268:Trifluoperazine / Q000494:pharmacology
D002135:Calcium-Binding Proteins; D002147:Calmodulin; D003837:Deoxy Sugars; D010704:Phorbols; D014268:Trifluoperazine; D003847:Deoxyglucose; D013755:Tetradecanoylphorbol Acetate; D002118:Calcium