Synergistic action of cimetidine and chlorpheniramine in prevention of restraint stress gastric ulceration in rats.
The role of histamine H1 and H2 receptors in acute gastric ulceration was studied using a rat restraint-stress model. Cimetidine, an H2 receptor antagonist, afforded some protection at all doses. A dose response study showed that the mean number of ulcers per rat decreased exponentially with increased doses, and the proportion of animals protected from any ulceration increased in a simple linear progression. A dose of cimetidine was chosen which gave only partial protection from ulceration, and to this was added chlorpheniramine, an H1 antagonist. H1 antagonism alone was found to give partial protection, but when both H1 and H2 blocker were given a synergistic effect was seen thus indicating that H1 receptors do have a role in acute gastric ulceration.
D000818:Animals; D002744:Chlorpheniramine / Q000008:administration & dosage / Q000627:therapeutic use*; D002927:Cimetidine / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006146:Guanidines / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications*
D006146:Guanidines; D002744:Chlorpheniramine; D002927:Cimetidine