A cross-over study comparing the kinetics of Tc-99m-labeled diisopropyl and p-butyl IDA analogs in patients.
Tc-99m-diisopropyl-IDA (DISIDA) and Tc-99m-p-butyl-IDA (BIDA) were compared in each of 33 patients who had serum bilirubins ranging from normal to 23.5 mg/dl. DISIDA exhibited quantitatively a higher liver uptake and faster rate of washout at all levels of bilirubinemia. There was a tendency for BIDA to have a slower blood clearance, particularly in hyperbilirubinemias exceeding 5 mg/dl. On visual comparison of the images, BIDA failed to identify the gallbladder in three icteric patients and dilated biliary tracts in two others.
D000328:Adult; D000368:Aged; D001659:Biliary Tract / Q000000981:diagnostic imaging* / Q000378:metabolism; D001663:Bilirubin / Q000097:blood; D002780:Cholestasis, Intrahepatic / Q000000981:diagnostic imaging; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D007098:Imino Acids / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000000981:diagnostic imaging* / Q000378:metabolism; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D013667:Technetium / Q000378:metabolism; D019785:Technetium Tc 99m Disofenin
D007098:Imino Acids; D015609:Organotechnetium Compounds; C024340:technetium Tc 99m (para-butyl)iminodiacetic acid; D013667:Technetium; D019785:Technetium Tc 99m Disofenin; D001663:Bilirubin