Immunomicrobiological monitoring of orovaccinal therapy in acute intestinal infections.
A double blind study in 42 patients (treated and controls) affected by acute uncomplicated salmonellosis was performed. The treatment consisted of an oral inactivated tetravaccine at the dose of 1 ampoule twice a day for 15 consecutive days. Microbiological and serological techniques (determination of intestinal secretory IgA by means of immunofluorescence, titration of copro and serum antibodies, quali-quantitative coprocultures) have shown that the administration of oral vaccine improved both the clinical and the immunomicrobiological picture in treated patients.
D000208:Acute Disease; D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D004311:Double-Blind Method; D005069:Evaluation Studies as Topic; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007167:Immunotherapy; D007410:Intestinal Diseases / Q000276:immunology / Q000628:therapy*; D007413:Intestinal Mucosa / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012480:Salmonella Infections / Q000276:immunology / Q000628:therapy*; D014613:Vaccines, Attenuated / Q000008:administration & dosage
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007071:Immunoglobulin A, Secretory; D014613:Vaccines, Attenuated