Inosine effect on high-energy phosphate content, mechanical activity of glycerinated fiber bundles, morphology and microcirculation in myocardium in toxi-allergic and allergic myocarditis.
It has been shown in experiments on rabbits on rabbits that in AM and TAM 80 mg/kg of inosine increase the total content of adenylic system nucleotides to the normal level and 160 mg/kg of inosine exceeds it. At the same time in the case of 80 mg/kg, ATP content is considerably increased and ADP is normalized while with 160 mg/kg ATP content becomes normal and ADP exceeds the normal level significantly. MGFB contractility returns to normal. Myocardial blood supply becomes more active both by increasing coronary circulation and probably through the Thebesian veins of the heart. It has been shown that on the one hand, inosine inhibits the development of an inflammatory process and on the other hand it considerably accelerates elimination and resolution of inflammatory foci.
D000244:Adenosine Diphosphate / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D007288:Inosine / Q000494:pharmacology*; D008833:Microcirculation / Q000187:drug effects; D009205:Myocarditis / Q000378:metabolism / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D011817:Rabbits; D013997:Time Factors
D007288:Inosine; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate