[Changes in hepatic blood flow after various types of portal shunt in the rat].
The relationship between liver trophicity and the early (24 h) or late (14 days) modifications of the hepatic blood flow were studied in the rat after several types of portosystemic shunts (portacaval shunt, mesocaval shunt, portacaval transposition and arterialization of the portal vein after portacaval shunt). Twenty-four hrs after portacaval shunt, the total hepatic blood flow was decreased to 60 p. 100 of the initial value and remained so during the following days. Within a week, there was a liver atrophy with a decrease of the LW/BW to 60 p. 100 of the preoperative value. Fourteen days after operation, the hepatic blood flow per gram of liver was similar to that observed preoperatively. Whatever the type of shunt, there was a significant relationship between total hepatic blood flow and liver weight, 14 days after operation. Thus, after portal diversion, the quality of the blood perfusing the liver has little incidence upon the maintenance of liver trophicity. These results suggest that hemodynamic factors are more important than hormonal (pancreatic) factors in the constitution of liver atrophy after end-to-side portacaval shunt.
D000818:Animals; D001284:Atrophy / Q000209:etiology; D008099:Liver / Q000473:pathology; D008102:Liver Circulation; D008297:Male; D011167:Portacaval Shunt, Surgical / Q000009:adverse effects; D011170:Portasystemic Shunt, Surgical / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains
Modifications du débit sanguin hépatique après différents types de dérivations portales chez le rat.