Eosinophilic granuloma as an incidental finding in malignant lymphoma.
A histiocytic lesion that is histologically indistinguishable from eosinophilic granuloma was discovered as an incidental finding in lymph nodes from six patients with malignant lymphoma. Three patients had Hodgkin's disease and three had non-Hodgkin's lymphoma. The occurrence of epitheloid histocytes or granulomatous reactions, or both, in lymphoid tissue is well known in malignant lymphomas, but the combination of eosinophillic granuloma and malignant lymphoma in the same lymph node has not been described previously. In all of our cases, the malignant lymphoma was more conspicuous than the histiocytic lesion, and the latter was limited to the sinuses. Both lesions were well delineated; features suggesting transition of one into the other were absent, even in sites where the two were juxtaposed. No extranodal eosinophilic granuloma was observed.
D000328:Adult; D004803:Eosinophilic Granuloma / Q000150:complications* / Q000473:pathology; D005260:Female; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging