Neurotoxicity of novel water-soluble contrast media for intrathecal application.
Novel nonionic contrast media were tested by injection into the subarachnoid space of the anterior fossae of guinea pigs, followed by EEG recording and histologic examination. Iopamidol was found to be more epileptogenic than metrizamide and P-297.
D000818:Animals; D002490:Central Nervous System / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D003287:Contrast Media / Q000008:administration & dosage / Q000633:toxicity*; D004569:Electroencephalography; D006168:Guinea Pigs; D007278:Injections, Spinal; D009485:Neuroradiography / Q000379:methods; D012640:Seizures / Q000139:chemically induced*; D012995:Solubility
D003287:Contrast Media