Haloperidol-induced plasticity of axon terminals in rat substantia nigra.
An electron micrographic morphometric analysis of nerve endings in substantia nigra of rats repeatedly treated with haloperidol was performed. Although most parameters showed no difference, drug-treated animals exhibited a significant shift in the distribution of relative numbers of axon terminals, suggesting neuroleptic-induced axon-collateral sprouting.
D000818:Animals; D001369:Axons / Q000187:drug effects; D003712:Dendrites / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D008854:Microscopy, Electron; D009068:Movement / Q000187:drug effects; D009473:Neuronal Plasticity / Q000187:drug effects*; D051381:Rats; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*
D006220:Haloperidol