The rheological efficiency of parenteral pentoxifylline (Trental) in patients with ischemic brain lesions. Preliminary results.
10 patients with ischemic cerebral lesions were treated with 1,200-1,500 mg parenteral pentoxifylline daily for 10 days. The following rheological parameters were determined before treatment and every third day after the start of treatment: erythrocyte deformability and aggregation, hematocrit, plasma viscosity and yield shear stress. 2 patients were submitted to isovolemic hemodilution. Among all rheological parameters, the erythrocyte deformability and the yield shear stress improved significantly, whereas plasma viscosity and erythrocyte aggregation did not change. 1 patient died 20 days after admission. 9 patients improved clinically. Because of the small number of patients correlations between clinical outcome and therapy are not possible.
D000328:Adult; D000368:Aged; D001809:Blood Viscosity; D002545:Brain Ischemia / Q000097:blood / Q000188:drug therapy*; D004903:Erythrocyte Aggregation; D004912:Erythrocytes / Q000502:physiology; D005260:Female; D006400:Hematocrit; D006438:Hemodilution; D006801:Humans; D008297:Male; D008875:Middle Aged; D010431:Pentoxifylline / Q000627:therapeutic use*; D010949:Plasma / Q000502:physiology; D012212:Rheology; D013805:Theobromine / Q000031:analogs & derivatives*
D013805:Theobromine; D010431:Pentoxifylline