Self-stimulation responses are altered following long-term but not short-term treatment with clorgyline.
Clorgyline (a selective monoamine oxidase-inhibiting antidepressant) given chronically facilitated hypothalamic self-stimulation in rats, while acute treatment was without effect. Furthermore, long-term but not short-term clorgyline treatment significantly attenuated the suppressive effect of the selective alpha 2-adrenergic agonist clonidine on this behavior. These findings suggest that adaptative alterations in the modulation of rewarded behavior by inhibitory presynaptic noradrenergic receptors may be involved in antidepressant efficacy.
D000818:Animals; D003000:Clonidine / Q000037:antagonists & inhibitors; D003010:Clorgyline / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007031:Hypothalamus / Q000187:drug effects*; D008297:Male; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012653:Self Stimulation / Q000187:drug effects*; D013997:Time Factors
D011437:Propylamines; D003010:Clorgyline; D003000:Clonidine