Acetylation of puromycin by Streptomyces alboniger the producing organism.
Streptomyces alboniger produces the antibiotic puromycin and expresses an enzymic activity which acetylates the drug using acetyl CoA. The N-acetyl-puromycin formed is biologically inactive against protein synthesis in Bacillus subtilis (as assayed in vivo).
D000107:Acetylation; D008658:Inactivation, Metabolic; D011691:Puromycin / Q000096:biosynthesis / Q000378:metabolism*; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism*
D011691:Puromycin