[In vitro and in vivo effects of paromomycin sulfate on tapeworm, especially Diphyllobothrium ditremum, and clinical effects on diphyllobothriasis in man].
Plerocercoids of D. ditremum were obtained from the Japanese surfsmelt (Hypomesus pretiosus) and administered to Golden hamsters. The animals were treated with paromomycin sulfate on the 16th day of infection. Anthelmintic effect was imperfection after administration of 530 mg/kg in 4 divided doses. Kamala and bithionol, however, successfully expelled the worm at the doses of 80 and 160 mg/kg and 12.5--70 mg/kg, respectively. The balloon-like structures and the other morphological changes of the tegument such as exfoliation of microtriches were remarkably observed on the worms immersed in 2% solution of paromomycin sulfate. Four human cases of diphyllobothriasis were treated with paromomycin sulfate at the doses of 46--56 mg/kg. No side effects were observed. Stool examination made 1 month after treatment were negative to the eggs. From these results, an anthelmintic effect of paromomycin sulfate was shown in the concentration of 2% on D. ditremum in vitro and in the dosage of 46--56 mg/kg in diphyllobothriasis lata patients.
D000293:Adolescent; D000328:Adult; D000818:Animals; D006224:Cricetinae; D004169:Diphyllobothriasis / Q000188:drug therapy*; D004170:Diphyllobothrium / Q000187:drug effects* / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D010303:Paromomycin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D010303:Paromomycin