Bladder and urethral dynamics in multiple sclerosis-like animal model.
Multiple sclerosis-like disease was induced in 18 rabbits by immunization with guinea pig spinal cord. The urodynamic studies conducted in the immunized rabbits showed a significantly lower maximal urethral pressure and a lower bladder capacity than those in the control group. We compared the urodynamic, clinical and histopathological parameters in the immunized rabbits. We conclude that the rabbit is an acceptable model for studying the bladder and urethral dynamics during various phases of experimental allergic encephalomyelitis (multiple sclerosis-like disease).
D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000473:pathology; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000503:physiopathology; D008297:Male; D009103:Multiple Sclerosis / Q000473:pathology / Q000503:physiopathology*; D011312:Pressure; D011817:Rabbits; D013116:Spinal Cord / Q000473:pathology; D014521:Urethra / Q000503:physiopathology*; D001743:Urinary Bladder / Q000503:physiopathology*
D000777:Anesthetics