No deleterious pulmonary effects from moderate transfusions of microaggregate-rich blood in dogs.
Dogs were transfused with moderate amounts of blood (28% of calculated blood volume) containing microaggregates as reflected in high screen filtration pressure. In one group of animals, the blood was filtered through a standard commercial filter and in another group a micropore transfusion filter was used. Comparison of the transfused groups with nontransfused control animals revealed a statistically significant decrease in Qt and pH 1 h after blood transfusion. There were no differences between the two transfused groups. It is concluded that moderate blood transfusions with aggregate-rich blood did not seem to seriously compromise lung function. Furthermore, the changes found after transfusion were related to the presence of factors in stored blood other than microaggregates.
D000818:Animals; D001769:Blood; D001803:Blood Transfusion; D001810:Blood Volume; D001835:Body Weight; D004285:Dogs; D004903:Erythrocyte Aggregation; D008168:Lung / Q000502:physiology*; D012129:Respiratory Function Tests; D013997:Time Factors; D014462:Ultrafiltration; D014655:Vascular Resistance