Vitamin D-induced myocardial lesions and the protection by carbocromen.
Effects of high doses of vitamin D on rat hearts were investigated 72 h after the administration of 500 000 U/kg. Histological examination showed disseminated focal necrosis with reactive round cell and granulocytic infiltration in the heart. The calcium content was increased by about 70%. These findings indicate vitamin D-induced myocardial lesions. Heart mitochondrial calcium binding and uptake activities were lower than in control animals. Na+-K+-ATPase activity of heart washed particles was reduced by the treatment with vitamin D whereas neither calcium binding and uptake activities of cardiac sarcoplasmic reticulum nor myofibrillar ATPase activity were affected. Carbocromen (20 and 100 mg/kg/d) treatment reduced vitamin D-induced decreases in mitochondrial calcium accumulating ability and Na+-K+-ATPase activity of heart washed particle, suggesting a beneficial effect of carbocromen against vitamin D-induced cardiac injury.
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000517:prevention & control; D002866:Chromonar / Q000494:pharmacology*; D003374:Coumarins / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008861:Microsomes / Q000187:drug effects; D008929:Mitochondria, Heart / Q000187:drug effects; D009206:Myocardium / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012519:Sarcoplasmic Reticulum / Q000187:drug effects; D013997:Time Factors; D014807:Vitamin D / Q000037:antagonists & inhibitors / Q000633:toxicity*
D003374:Coumarins; D014807:Vitamin D; D002866:Chromonar