[Changes in ocular tonus, pH and concentration of ascorbic acid and lactic acid in the aqueous humor of rabbits treated with clonidine].
The authors state the results of their research on the modification of the aqueous humor caused by the instillation of the Clonidine in a group of ten rabbits. The results of these studies illustrate the variations of pH, the ocular tone, the concentration of lactic and ascorbic acid. In all the rabbits examined was instillated Clonidine for one hour in RE while in LE distilled water was instilled for the control. For two hours from the beginning of the experiment every 10 minutes measurements of the ocular tone in both eyes were taken. At the end of two hours a sample of aqueous humor was taken from LE and RE. It was found that: 1) The drugs produced a vary quick and prolonged decrease of the ocular tone. 2) There are no significant variations in the pH or in the concentration of lactic acid. 3) There was a notable reduction of the concentration of ascorbic acid.
D000818:Animals; D001082:Aqueous Humor / Q000032:analysis / Q000187:drug effects*; D001205:Ascorbic Acid / Q000032:analysis; D003000:Clonidine / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007429:Intraocular Pressure / Q000187:drug effects*; D007773:Lactates / Q000032:analysis; D011817:Rabbits; D014065:Tonometry, Ocular
D007773:Lactates; D003000:Clonidine; D001205:Ascorbic Acid
Modificazioni del tono oculare, del pH, della concentrazione di acido ascorbico e di acido lattico nell'umore acqueo di coniglio trattato con clonidina.