title: Pharmacological properties of new 11H-indeno[1,2-b]-quinolin-11-one derivatives.
abstract: Pharmacological properties of 7 new 11H-indeno [1,2-b]quinolin-11-ones (1-7) were investigated in mice and rats. For comparison indomethacin (IND) and phenylbutazone (PHB), were studied. Compounds 1 and 3-7 produced sedative action. Compound 2 had a stimulatory effect. IND and PHB did not affect the central nervous system. All tested compounds showed analgesic properties, similar to those of IND and more pronounced than those of PHB. Compounds 1, 2, 3, 4 had anti-inflammatory action. The most active of them 10-methyl-amine derivative (compound 2) was more effective than IND and PHB.
mesh_terms: D000700:Analgesics; D000818:Animals; D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D002375:Catalepsy / Q000139:chemically induced; D003913:Dextroamphetamine / Q000494:pharmacology; D006801:Humans; D007192:Indenes / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010653:Phenylbutazone / Q000494:pharmacology; D000091402:Prohibitins; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D007192:Indenes; C000717328:PHB protein, human; C000717332:Phb protein, rat; D000091402:Prohibitins; D011804:Quinolines; D010653:Phenylbutazone; D003913:Dextroamphetamine; D007213:Indomethacin