Development of a carcinogen-induced rat colon cancer with lymph-node metastases.
The progression from normal colonic mucosa to invasive adenocarcinoma of the colon with lymph-node metastases was documented in Sprague-Dawley rats receiving 30 mg of N-methyl-N-nitrosourea via intrarectal injections. Histologically, these tumors closely resemble human colonic cancer. This model is predictable and reproducible. It offers a genetically nonidentical rat model for the development of cancer biology and therapy models.
D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000473:pathology*; D007267:Injections; D008207:Lymphatic Metastasis; D008297:Male; D008770:Methylnitrosourea; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012007:Rectum
D008770:Methylnitrosourea