Tumour pH in human mammary carcinoma.
Human tumour pH was investigated using the new Philips C902S tissue pH electrode. In 22 mammary carcinomas a pH of 7.29 +/- 0.050 (S.E.M.) was observed, whereas in the human subcutis this value was 7.63 +/- 0.034. Tumour pH in some experimental rat tumours was slightly lower than in humans, 7.15 +/- 0.029 in rhabdomyosarcoma BA1112 and 7.07 +/- 0.024 in a small group of other miscellaneous rat tumours. Rat skeletal muscle was found to have a pH of 7.59 +/- 0.070. It is concluded that a small but highly significant (P less than 0.0001) pH difference exists between human mammary carcinoma and human subcutis. This difference is smaller than expected on the basis of animal studies.
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism*; D004566:Electrodes; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012208:Rhabdomyosarcoma / Q000378:metabolism; D012513:Sarcoma, Experimental / Q000378:metabolism; D012867:Skin / Q000378:metabolism