Prolactin and ergocryptine effects on mucus glycoproteins of the rat ileum.
The present work reports observations from a first study on the effect of prolactin on mucous cells of the mammalian ileum. Sprague-Dawley rats were treated with prolactin or with the prolactin-inhibitor ergocryptine. Light microscopic histochemical study revealed that ergocryptine increased the number both of Alcian Blue-positive mucous cells and of the total number of mucous cells in the ileal crypts. Prolactin treatment apparently decreased the number of Alcian Blue pH 1.0-positive (sulphated glycoprotein-containing) mucous cells on the villi but was without effect on crypt cells. The implications of these observations are discussed.
D000818:Animals; D004873:Ergolines / Q000494:pharmacology*; D006023:Glycoproteins / Q000378:metabolism*; D006651:Histocytochemistry; D007082:Ileum / Q000166:cytology / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011388:Prolactin / Q000494:pharmacology*; D051381:Rats
D004873:Ergolines; D006023:Glycoproteins; C100272:ergotoxine; C100269:ergocryptine; D011388:Prolactin