[Membrane model of the regulation of proliferation: or predictions of the theory].
Experimental consequences predicted by the membrane theory of cell proliferation are considered. In this theory, the conformational transitions are conditioned by the existence of the mechanical frame embracing normal cells as a whole and they induce the phase transitions in the lipid bilayer. It is interesting to record the lateral mobility of lipid molecules, because the theory predicts the principle difference between the line dependence of lipid fluidity in membranes of normal and tumour cells. Possible measurements of lateral mobility of non-lipid membrane components are described in detail, and the enhancement of diffusion is expected under mitogenic stimulation. Special attention is given to a possible method of overcoming G1-preferability and to obtaining a large population of non-proliferating cells in G2 state.
D002453:Cell Cycle; D002455:Cell Division; D002462:Cell Membrane / Q000648:ultrastructure*; D007399:Interphase; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000502:physiology; D011975:Receptors, Mitogen / Q000502:physiology
D008563:Membrane Lipids; D011975:Receptors, Mitogen
Membrannaia model' reguliatsii proliferatsii: predskazaniia teorii.