[Photosensitivity associated with carprofen (Imadyl), a new non-steroidal anti-inflammatory drug].
Carprofen is a new non-steroidal anti-inflammatory drug and a phenylpropionic acid derivative. It seldom causes pruritus, erythema or urticaria. Since 1 year, we have observed 8 photosensitive eruptions associated with Carprofen, a surprising side effect for this group of derivatives. The skin eruption started from 4 days to 3 weeks after the initiation of the treatment and was always limited to the exposed areas of the skin. The eruption was erythematopapular, but also vesioular or bullous. 2 cases required systemic corticosteroids. Photo patch tests were positive, suggesting a photoallergic process. Phototherapy should be avoided in patients treated with carprofen.
D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D002227:Carbazoles / Q000009:adverse effects*; D005148:Facial Dermatoses / Q000139:chemically induced*; D005260:Female; D006229:Hand Dermatoses / Q000139:chemically induced*; D006801:Humans; D008027:Light / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D010789:Phototherapy / Q000009:adverse effects; D012621:Seasons
D000893:Anti-Inflammatory Agents; D002227:Carbazoles; C007005:carprofen
Photosensibilisation au carprofène (Imadyl), un nouvel anti-inflammatoire non stéroïdien.