Nonmineralized and mineralized compartments of bone: the role of pyridinoline in nonmineralized collagen.
Collagen tryptic peptides obtained from the nonmineralized and mineralized compartments of diaphyseal bone have different distributions of intermolecular crosslinks. Pyridinoline, a collagen crosslink thought to be associated with chronologically older bone, was detected in peptides from nonmineralized collagen but not from mineralized collagen. Mineralization may prevent collagen maturation; conversely, pyridinoline in nonmineralized collagen may decrease the intermolecular distances among collagen chains in fibrils and preclude mineralization.
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002645:Chickens; D002845:Chromatography / Q000379:methods; D003094:Collagen / Q000378:metabolism*; D008903:Minerals / Q000378:metabolism*
D000596:Amino Acids; D008903:Minerals; C015484:pyridinoline; D003094:Collagen