title: Effect of in vitro administration of LH, prolactin separately, and LH and prolactin in mixture on cultured Leydig cells from mouse testes: II. Age-related alterations of androgen secretion.
abstract: The effect of gonadotropic hormones on androgen level in media of cultured Leydig cells isolated from mouse testes of various age was investigated. Changes of androgen level were connected with the age of mice. The highest secretory level of androgen was found in cultures of Leydig cells from mature 60 day old animals, which then decreased in 7 month old mice. Stimulating effect of LH and PRL on hormonal secretion by cultured Leydig cells was observed.
mesh_terms: D000367:Age Factors; D000728:Androgens / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D004338:Drug Combinations; D007985:Leydig Cells / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011388:Prolactin / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000728:Androgens; D004338:Drug Combinations; D011388:Prolactin; D007986:Luteinizing Hormone