Complete Freund's adjuvant-induced pneumonia in swine: a model of interstitial lung disease.
Intravenously administered complete Freund's adjuvant, emulsified in saline, induced a lesion in the porcine lung characterized by a disseminated histiocytic interstitial pneumonia, type II pneumocyte proliferation and granulomatous arteriolitis. In addition, there was a persistent increase in numbers of alveolar macrophages. The lesion was well developed in 7 days. The sequential development and early resolution of the light microscopic lesions was studied for a period of 21 days after inoculation. The administration of Freund's adjuvant induced a spectrum of lesions typical of many forms of interstitial lung diseases of man and domestic animals. The pig is a suitable host for the investigation of the pulmonary inflammatory response and the repair mechanisms involved in chronic lung disease produced by infectious agents or environmental antigens.
D000818:Animals; D004195:Disease Models, Animal; D005620:Freund's Adjuvant / Q000633:toxicity*; D008168:Lung / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D011014:Pneumonia / Q000139:chemically induced / Q000473:pathology*; D013552:Swine
D005620:Freund's Adjuvant