Leukotrienes C and D induce aspirin-sensitive bronchoconstriction in the guinea-pig.
Branchoconstriction in the guinea-pig due to leukotrienes C4 and D4 in vivo and in vitro was suppressed by aspirin. Since contracting effects of putative mediators of bronchial asthma should be refractory to inhibition of cyclooxygenase, our results indicate that release of leukotrienes in the guinea-pig does not alone account for anaphylactic bronchoconstriction.
D000403:Airway Resistance / Q000187:drug effects*; D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D001980:Bronchi / Q000187:drug effects*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D013189:SRS-A / Q000494:pharmacology*
D013189:SRS-A; D001241:Aspirin