Complete nucleotide sequence of a chicken alpha-globin cDNA.
The entire sequence of a 541 bp insert in recombinant plasmid pHb1003 has been determined. This plasmid, which was shown to carry a cloned cDNA copy of the chicken alpha-globin mRNA, contains the complete structural gene as well as 19 bp of the 5'-untranslated region and 99 bp of the 3'-untranslated region. This sequence may encode a non-adult alpha-globin gene, especially since the cDNA clones were generated from phenylhydrazine-induced, globin-specific mRNA extracted from anemic white leghorns. The possibility that this alpha-globin might represent a stress globin is considered.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002645:Chickens; D003001:Cloning, Molecular; D003062:Codon; D004247:DNA / Q000235:genetics; D005914:Globins / Q000235:genetics*; D010957:Plasmids; D012333:RNA, Messenger / Q000235:genetics
D003062:Codon; D012333:RNA, Messenger; D005914:Globins; D004247:DNA