Non-immunological recognition and killing of xenogeneic cells by macrophages. III. Destruction of fish cells by murine macrophages.
Non-immune non-activated murine peritoneal macrophage killed in vitro fish (Cyprinus carpio) PHA-induced lymphoblasts. Addition of PHA and WGA to effector-target cell cultures did not potentiate the killing. This killing (xenolysis) was expressed by non-elicited and thioglycollate-elicited macrophages as well as by macrophages depleted of lymphocytes. It is suggested that mammalian macrophages have a xenolytic potential towards phylogenetically distant species which is analogous to the capacity of invertebrate phagocytes to destroy xenografts.
D000818:Animals; D002347:Carps / Q000276:immunology*; D002450:Cell Communication; D002469:Cell Separation; D002470:Cell Survival; D003530:Cyprinidae / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005260:Female; D037102:Lectins / Q000276:immunology; D008214:Lymphocytes / Q000502:physiology*; D008262:Macrophage Activation; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D010835:Phytohemagglutinins / Q000494:pharmacology; D014909:Wheat Germ Agglutinins
D037102:Lectins; D010835:Phytohemagglutinins; D014909:Wheat Germ Agglutinins