Damage to sensory hairs of inner hair cells after exposure to noise in rabbits without outer hair cells.
We investigated if the noise-induced damage to the stereocilia of inner hair cells (IHCs) was dependent on the integrity of the outer hair cells (OHCs) in rabbit. Prior to the noise exposure a total loss of OHCs in the basal 1.5 to 2 turns was induced by administration of kanamycin (400 mg/kg for 10 days). This left the IHCs apparently normal as observed in the scanning electron microscope. These animals exhibited a 20-60 dB hearing loss before noise exposure. In spite of this pronounced hearing loss, the fusion and inclination of the IHC stereocilia were extensive in these noise-exposed ears. The stereocilia damage occurred at the same noise exposure and was as prominent or even more pronounced than has been noted in ears exposed to noise only. Under the assumption that kanamycin causes selective destruction of OHCs, the results can be interpreted as evidence that the OHCs facilitate the IHCs at low sound levels without being involved in the process which damages IHC stereocilia at high levels of noise.
D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects; D006198:Hair Cells, Auditory / Q000187:drug effects / Q000473:pathology*; D006199:Hair Cells, Auditory, Inner / Q000473:pathology*; D006317:Hearing Loss, Noise-Induced / Q000473:pathology*; D007612:Kanamycin / Q000633:toxicity; D008855:Microscopy, Electron, Scanning; D009925:Organ of Corti / Q000187:drug effects / Q000473:pathology; D011817:Rabbits
D007612:Kanamycin