Effects of a single oral dose of phenobarbital on prolactin, growth hormone and luteinizing hormone in normal women.
The effects of a single oral dose of phenobarbital (PB) on the 24 h secretion of prolactin, growth hormone and luteinizing hormone have been evaluated in normal women. An EEG record was taken and barbiturate levels assayed in serum. A statistically significant decrease of growth hormone 24 h mean levels was observed and growth hormone and prolactin values during sleep were diminished. No changes in luteinizing hormone concentrations were observed. After PB the EEG showed no important alterations in sleep pattern, but on the power analysis an increase above 16 Hz absolute power was detected during the waking period.
D000284:Administration, Oral; D000328:Adult; D002940:Circadian Rhythm; D004569:Electroencephalography; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism*; D010634:Phenobarbital / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D011388:Prolactin / Q000378:metabolism*; D012890:Sleep
D011388:Prolactin; D007986:Luteinizing Hormone; D013006:Growth Hormone; D010634:Phenobarbital