[Hypotensive effect and changes of arterial pressure variability induced by treatment with labetalol in patients with slight and moderate arterial hypertension].
To evaluate the hypotensive efficacy of labetalol (600 mg/day) six mild to moderate hypertensive patients were studied by the indirect continuous blood pressure monitoring with the Del Mar Avionics Pressurometer 111 degrees. This technique gives a much larger number of blood pressure values in a greater variety of conditions than the conventional Riva-Rocci sphygmomanometer. After one month of continuous therapy there was a substantial reduction in systolic and diastolic pressure. The increased index of Kurtosis revealed a decreased blood pressure variability. The circadian changes of blood pressure were not significantly affected, but the morning peak was smoothed by labetalol.
D001794:Blood Pressure / Q000187:drug effects; D004983:Ethanolamines / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007741:Labetalol / Q000494:pharmacology / Q000627:therapeutic use*
D004983:Ethanolamines; D007741:Labetalol
Effetto ipotensivo e modificazioni della variabilità della pressione arteriosa indotti dal trattamento con labetalolo in pazienti con ipertensione arteriosa lieve o moderata.