Effect of phenobarbital on the carcinogenesis of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide in rats.
Male Fischer rats were fed a N-[4-(5-nitro-2-furyl]-2-thiazolyl]formamide (FANFT) diet for 6 weeks followed by a phenobarbital (PB) diet for an additional 86 weeks. PB significantly increased the incidence of bladder tumors, but not the incidence of hepatic foci and areas of cellular alterations caused by FANFT. The results suggest that PB may be a weak promoter for bladder carcinogenesis, and that FANFT may not be an initiator for hepatocarcinogenesis.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D004347:Drug Interactions; D004357:Drug Synergism; D005200:FANFT / Q000633:toxicity*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*; D008297:Male; D009374:Neoplasms, Experimental / Q000473:pathology; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D013844:Thiazoles / Q000633:toxicity*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000473:pathology
D002273:Carcinogens; D013844:Thiazoles; D005200:FANFT; D010634:Phenobarbital