Frequently used lipid-lowering drugs having no guaranteed effect.
The therapeutic value of frequently used lipid-lowering agents such as the essential phospholipids (EPL), pyridoxal-phosphate (PP) and cynarin as well as the use of chenodeoxycholic acid and disaccharidase inhibitors in the treatment of various forms of hyperlipoproteinaemia is discussed critically. In two own clinical studies with orally administered EPL and PP in hyperlipoproteinaemic outpatients we were unable to establish clinically relevant effects on blood lipid and lipoprotein levels. In our opinion reported positive results with EPL, PP and cynarin are partially due to the methods of administration, selection of inpatients and dietary influences.
D002635:Chenodeoxycholic Acid / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D002934:Cinnamates / Q000494:pharmacology; D004186:Disaccharidases / Q000037:antagonists & inhibitors; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood / Q000188:drug therapy; D008055:Lipids / Q000097:blood*; D010743:Phospholipids / Q000494:pharmacology*; D011732:Pyridoxal Phosphate / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
D002934:Cinnamates; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D002635:Chenodeoxycholic Acid; D011732:Pyridoxal Phosphate; C100257:cynarine; D002784:Cholesterol; D004186:Disaccharidases