"Is magnesium depletion the reason for ototoxicity caused by aminoglycosides?".
Aminoglycoside antibiotic drugs may cause ototoxicity and nephrotoxicity. Our hypothesis postulates that aminoglycosides cause ototoxicity by a mechanism of magnesium depletion in the hair cells of the cochlea. The same mechanism maybe responsible for nephrotoxicity caused by aminoglycosides.
D000617:Aminoglycosides / Q000009:adverse effects*; D001696:Biomechanical Phenomena; D003051:Cochlea / Q000293:injuries; D006311:Hearing Disorders / Q000139:chemically induced* / Q000209:etiology; D006801:Humans; D008274:Magnesium / Q000502:physiology; D008275:Magnesium Deficiency / Q000150:complications*
D000617:Aminoglycosides; D008274:Magnesium