[Effect of tolbutamide on the electrical activity of bursting neurons in Helix pomatia].
The effect of tolbutamide, an inhibitor of proteinkinase reaction, on electrical activity of the RPal bursting neuron was studied in Helix pomatia. It is shown that 5 mM tolbutamide produced a complete and reversible block of pacemaker activity of the neuron. It is concluded that cell proteinkinase is involved in the genesis of neuronal bursting activity.
D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D003864:Depression, Chemical; D005724:Ganglia / Q000166:cytology; D006372:Helix, Snails; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010507:Periodicity; D011494:Protein Kinases / Q000502:physiology; D014044:Tolbutamide / Q000494:pharmacology*
D014044:Tolbutamide; D011494:Protein Kinases
Vliianie tolbutamida na élektricheskuiu aktivnost' pachechnogo neĭrona vinogradnoi ulitki.