[Antitumor activity of chlorella extract, PCM-4, by oral administration].
The antitumor activity of a water-soluble substance extracted from Chlorella regulararis S-50, PCM-4, against murine transplanted tumors was investigated. PCM-4 is composed of sugar (25.7%), protein (51.5%) and nucleic acid (18.7%). By oral administration of PCM-4, both the growth of Sarcoma 180 and Meth A, subcutaneously implanted into mice, and ascites hepatoma AH 44 and AH 41C, intravenously implanted into rat, was inhibited. PCM-4 also showed antitumor activity against Sarcoma 180 and Meth A by intraperitoneal administration. The finding that PCM-4 has no direct growth-inhibition effect on tumor cells in vitro suggests that the antitumor activity of PCM-4 be elicited from the host-mediated response system.
D000284:Administration, Oral; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002708:Chlorella; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy*; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012510:Sarcoma 180 / Q000188:drug therapy*
C038750:PCM 4; D010936:Plant Extracts