[Possible mechanisms of the occurrence of chromosome aberrations. II. The formation of aberrations induced by UV irradiation].
The report is concerned with one of possible mechanisms of emergence of chromosome aberrations after UV-irradiation of mammalian cells. The process is initiated by DNA cross-links following thymine dimerization, and is completed during mitosis. A model to account for formation of chromosome aberrations has been offered. It is compatible with the modern concept of a scaffolding model for metaphase chromosome structure in which the scaffold organizes DNA into loops along its length. The model predicts the importance of a process of mitotic chromosome isolation during aberration formation (in addition to the processes of DNA replication, reparation and chromosome association). Another feature of the model is an attempt to describe formation of aberrations under conditions of true DNA reparation.
D000818:Animals; D002478:Cells, Cultured; D002842:Chromatids / Q000528:radiation effects; D002869:Chromosome Aberrations; D004247:DNA / Q000235:genetics; D004260:DNA Repair / Q000528:radiation effects; D004261:DNA Replication / Q000528:radiation effects; D051379:Mice; D008938:Mitosis / Q000528:radiation effects; D008957:Models, Genetic; D009154:Mutation; D014466:Ultraviolet Rays
D004247:DNA
Vozmozhnye mekhanizmy vozniknoveniia perestroek khromosom. Soobshchenie II. Obrazovanie perestroek pri UF-obluchenii.