[Comparative study of the effectiveness of inactivated influenza vaccine preparations].
The reactogenicity, safety, immunogenicity and epidemiological effectiveness of inactivated virion vaccinal preparations from strains A (H3N2) Texas 1/77a, A (H1N1) and split adsorbed influenza chemical vaccine, as well as the character of local and systemic reactions to these vaccines were studied. The vaccinees showed a high percentage of seroconversions (42-69.4%) with antibody titers increasing 5 times and more. At the period of the epidemic outbreak of influenza in January 1980, caused by influenza virus A (H3N2) Texas 1/77a, morbidity rate among persons immunized with the vaccine homologous to the epidemic strain was 2.5 times lower than among nonimmunized persons.
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D001831:Body Temperature / Q000187:drug effects; D004341:Drug Evaluation; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D014771:Virion / Q000276:immunology
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated
Sravnitel'noe izuchenie éffektivnosti inaktivirovannykh protivo-grippoznykh vaktsinnykh preparatov.