[Myocardial contractility in newborns following tokolysis with beta-sympathicomimetics].
Using non-invasive methods (carotic pulse sphygmography, electro- and phonocardiography) the effect of maternal tokolysis with beta-sympathicomimetics (Fenoterol in combination with Verapamil) on the systolic intervals in neonates was investigated as a global measurement of cardiac capacity. In 39 newborns (gestational age 35.1 +/- 1.7 weeks), after an average duration of tokolysis of 37.5 days (1-210) with normal birth and normal primary adaptation, the findings as compared with a control group of 22 neonates were as follows: increased pre-ejection time (80.7 +/- 20 as compared with 67.5 +/- 7.5 ms), increased intraventricular time (38.6 +/- 14.3 as compared with 34.9 +/- 7.0 ms) and a higher quotient of pre-ejection and left-ventricular ejection time (0.476 +/- 0.127 as compared with 0.369 +/- 0.06). There are statistically established correlations with the duration of tokolysis. The findings suggest a myocardial is as a rule successfully compensated for by an increase in heart rate, and which disappears in the course of the first week of life.
D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D005280:Fenoterol / Q000627:therapeutic use*; D006339:Heart Rate; D006801:Humans; D007231:Infant, Newborn; D009200:Myocardial Contraction / Q000187:drug effects*; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D013318:Stroke Volume / Q000187:drug effects; D013997:Time Factors; D014700:Verapamil / Q000627:therapeutic use*
D004983:Ethanolamines; D005280:Fenoterol; D014700:Verapamil
Myokardiale Kontraktilität Neugeborener nach Tokolyse mit Beta-Sympathikomimetika.