Identification of a factor blocking a cellular cytotoxicity reaction in pregnant serum.
A blocking factor present in the serum of pregnant women is able to inhibit non-specifically a cellular cytotoxicity reaction. It is a glycoprotein, migrating in the alpha-globulin region with a molecular weight of about 210,000 daltons. Its absence from the serum of women with recurrent abortions could predict the outcome of pregnancy.
D000026:Abortion, Habitual / Q000276:immunology; D000022:Abortion, Spontaneous / Q000276:immunology; D002850:Chromatography, Gel; D003602:Cytotoxicity, Immunologic; D005260:Female; D006023:Glycoproteins / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007108:Immune Tolerance; D007122:Immunoelectrophoresis; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood* / Q000276:immunology / Q000302:isolation & purification
D006023:Glycoproteins; D011257:Pregnancy Proteins