Chromosome replication in mouse intraspecific hybrids.
Hybrid cells (HY SS2 and HY SS6) arising from the fusion of diploid cells of the mouse lymphosarcoma LS/BL and L cells resistant to 8-azaguanine (HGPRT-) showed slower growth and a longer generation time than the parent lines. The inter- and intrachromosomal timing and patterns of early chromosome DNA replication of parent cells was preserved in the hybrid genome and was not influenced by loss of telocentric chromosomes from LS/BL or L (HGPRT-) cells. Thus DNA chromosome replication sequences are not dependent on the presence of a complete set of chromosomes of the parent cells and do not therefore seem to be a result of interaction between chromosomes not segregated in the hybrid genome.
D000818:Animals; D002453:Cell Cycle; D002455:Cell Division; D002460:Cell Line; D002875:Chromosomes / Q000502:physiology*; D004261:DNA Replication; D006822:Hybrid Cells / Q000502:physiology*; D007739:L Cells / Q000502:physiology; D008228:Lymphoma, Non-Hodgkin / Q000503:physiopathology; D051379:Mice; D009374:Neoplasms, Experimental / Q000503:physiopathology