title: Cardiovascular lymphoscintigraphy.
abstract: The technique of lymphoscintigraphy when applied to the heart and blood vessels correlates well with results of anatomic investigations of arterial and cardiac lymphatic vessels reported in the literature. Five dogs and eight rabbits underwent lymphoscintigraphy of the heart and aorta, as well as the iliac, femoral, and tibial arteries. After surgical exposure, approximately 500 microCi of 99mTc-labelled antimony sulfide was injected into the myocardium or the adventitial-medial plane of an artery. The colloid particle size of 4 to 12 m mu causes resorption and transport only via the lymphatic vessels. Twenty-one preparations were imaged from 2 to 48 hours after administration. This method provides a functional demonstration that the tibial and femoral arteries of both species are invested with lymphatics. The first echelon of lymph nodes which drain muscular arteries are imaged within 2 hours. Regional lymph nodes could not be seen to drain the aorta or iliac arteries. Anterior left ventricular myocardial injection in the dog showed a single cardiac lymph node. This drainage pattern has been described previously by other investigators. In the rabbit a similarly placed injection visualized a group of regional cardiac nodes. Ligation of the collecting ducts afferent to the cardiac node in the dog prevented removal of the isotope from the heart at 3, 6, and 9 hours. At 24 hours the liver and spleen were imaged, the radiocolloid gaining entrance to the blood vascular system presumably via myocardial lymphaticovenous anastomoses. Lymphoscintigraphy reflects physiologic processes such as lymph transport, filtration, and reticuloendothelial function. It defines regional patterns of cardiac and arterial lymph drainage. It can confirm experimentally produced impairment of lymph drainage from a defined area of tissue. Lymphoscintigraphy should be useful in the investigation of the significance of lymph drainage to diseases of the heart and blood vessels.
mesh_terms: D000818:Animals; D000965:Antimony; D001011:Aorta / Q000000981:diagnostic imaging; D001158:Arteries / Q000000981:diagnostic imaging*; D003326:Coronary Circulation; D004285:Dogs; D005263:Femoral Artery / Q000000981:diagnostic imaging; D006321:Heart / Q000000981:diagnostic imaging*; D007083:Iliac Artery / Q000000981:diagnostic imaging; D008026:Ligation; D008099:Liver / Q000000981:diagnostic imaging; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D061305:Lymphoscintigraphy; D011817:Rabbits; D013154:Spleen / Q000000981:diagnostic imaging; D013667:Technetium; D017556:Technetium Compounds
chemical_list: D017556:Technetium Compounds; C019096:technetium Tc 99m antimony sulfide; D013667:Technetium; D000965:Antimony