Changes in the compositions of the null cell compartment with murine autoimmunity.
The subpopulations that comprise the null cell compartment were examined sequentially in various strains of autoimmune-prone mice. Different patterns emerged that were consistent within strains but differed from strain to strain. Abnormalities appear earlier in life in short-lived mice, such as male BXSB and MRL/l mice, than in relatively long-lived strains, such as female BXSB and NZB mice. The accumulation of T cells in MRL/l mice was accompanied by null cell changes that contrasted with those that developed in AKR/J mice after their spleens were infiltrated with leukemic T cells. It would seem that lymphocyte perturbations with murine autoimmunity also involve their precursor cells and that these precursor cell changes vary in different strains, perhaps in relation to different genetic factors.
D000375:Aging; D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D005260:Female; D008215:Lymphocytes, Null / Q000276:immunology*; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008815:Mice, Inbred Strains; D009929:Organ Size; D013045:Species Specificity; D013154:Spleen / Q000254:growth & development / Q000276:immunology; D013950:Thymus Gland / Q000254:growth & development / Q000276:immunology
D001323:Autoantibodies