Ellipticine-induced alteration of model and natural membranes.
The modification of certain membrane properties by ellipticine derivatives was examined. The amphiphilic 9-methoxyellipticine was the most efficient in disorganizing membrane structure and in inducing leaks of liposomes, haemolysis of intact human erythrocytes. This drug and the dipolar 9-amino- and 9-hydroxyellipticine were equally efficient in decreasing the surface charge of membranes and in inhibiting the respiration of an isolated bacterial membrane.
D000470:Alkaloids / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects*; D002463:Cell Membrane Permeability / Q000187:drug effects; D004586:Electrophoresis; D004611:Ellipticines / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects*; D005452:Fluoresceins; D005454:Fluorescence Polarization; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008081:Liposomes; D008837:Micrococcus / Q000187:drug effects / Q000648:ultrastructure; D010101:Oxygen Consumption; D013050:Spectrometry, Fluorescence
D000470:Alkaloids; D004611:Ellipticines; D005452:Fluoresceins; D008081:Liposomes; C024098:6-carboxyfluorescein; C038373:9-aminoellipticine; C001729:9-methoxyellipticine