[Isolated hypothyroid dwarfism. Study of 18 cases].
Isolated hypothyroid dwarfism is defined by growth retardation without other clinical symptoms or signs of thyroid insufficiency. This study reports 18 cases: 6% of a series of cases of hypothyroidism in childhood. The main features are: mean bone age lower than height age; low plasma thyroxine in 16 patients, definitely low triiodothyronine in one only, high plasma TSH in all cases, with exaggerated response to TRH stimulation test; enlarged sella turcica in 11 patients. The thyroid gland was ectopic in 14 patients, the 4 others had a thyroid in normal place. Treatment with thyroid hormones sharply increased the growth velocity and the bone maturation. However its delay did not allow to obtain a complete catch-up of height.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004392:Dwarfism / Q000209:etiology*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D008297:Male; D013997:Time Factors
Le nanisme hypothyroïdien isolé. Etude de 18 observations.