Thyroid-stimulating immunoglobulins in neonatal Graves's disease.
Two patients with neonatal Graves's disease are reported. One of them had a delayed onset because of suppression of the fetal thyroid gland by antithyroid drug taken by the mother during pregnancy. Thyroid-stimulating immunoglobulins (TSAb), measured by a receptor assay, were present in both babies when they were thyrotoxic, and also in their mothers. TSAb were undetectable in both babies 1 year after birth. This strongly supports a pathogenetic role of TSAb in this condition through transplacental transfer of maternal TSAb.
D005260:Female; D006111:Graves Disease / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000276:immunology*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013972:Thyrotropin / Q000276:immunology*; D013997:Time Factors
D007136:Immunoglobulins; D013972:Thyrotropin