Cerebral gigantism of hypothalamic origin.
In five cases of Sotos Syndrome serum somatomedin activities were measured. In two of these cases elevated levels and an increased secretion of growth hormone was observed. In one case (index case) a suspected hypothalamic tumor mass could be excluded, but hydrocephalus with increased intracranial pressure was present. The pathogenesis of gigantism in this syndrome is discussed.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005877:Gigantism / Q000097:blood / Q000175:diagnosis*; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D008297:Male; D013002:Somatomedins / Q000097:blood; D013577:Syndrome
D013002:Somatomedins; D013006:Growth Hormone