Postzygotic D/D translocation homozygosity associated with recurrent abortions.
A Robertsonian translocation involving homologous D chromosomes was found in two cases with a history of recurrent abortions. In the first case the propositus was a 37-year-old phenotypically normal man who had a balanced t(14q14q) translocation. In the second case, a 27-year-old phenotypically normal woman was found to be a balanced t(15q15q) translocation carrier. The recurrent abortions in both cases were probably owing to this translocation.
D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D002869:Chromosome Aberrations / Q000150:complications*; D025063:Chromosome Disorders; D002901:Chromosomes, Human, 13-15; D005260:Female; D006720:Homozygote; D006801:Humans; D008297:Male; D011247:Pregnancy; D014178:Translocation, Genetic