Effects of age and sex on hexachloro-1,3-butadiene toxicity in the Fischer 344 rat.
Effects of age and sex on hexachloro-1,3-butadiene (HCBD) nephrotoxicity were determined 24 hours after a single dose (0, 25, 50, 100 or 200 mg/kg) in 28- and 63-day-old Fischer 344 rats. HCBD treatment significantly increased the kidney to body weight ratio but had little effect on the liver to body weight ratio. The 28-day-old rats were more susceptible to HCBD nephrotoxicity judged by elevated blood urea nitrogen, decreased renal cortical accumulation of p-aminohippurate and tetraethylammonium. Adult female rats (63-day-old) appeared to be more susceptible to HCBD nephrotoxicity than males at the low dose (50 mg/kg).
D000375:Aging; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002070:Butadienes / Q000633:toxicity*; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000254:growth & development; D008099:Liver / Q000187:drug effects* / Q000254:growth & development; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D012737:Sex Factors
D002070:Butadienes; C001335:hexachlorobutadiene; D000410:Alanine Transaminase