Prolonged retention in the circulation of emulsified lipid-coated perfluorochemicals.
A new emulsion of perfluorochemical, in which the emulsified particles are coated with lecithin, has been infused in rats. The retention of the emulsified perfluorochemical in the circulation has been prolonged more than 300% by injections of lecithin, which maintain a high concentration of lecithin in the plasma. This prolonged retention in the circulation resulted in a marked decrease in the amount of perfluorochemical retained in the liver and spleen.
D000818:Animals; D001802:Blood Substitutes / Q000378:metabolism*; D002784:Cholesterol / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D005466:Fluorocarbons / Q000008:administration & dosage / Q000097:blood*; D008099:Liver / Q000378:metabolism; D010713:Phosphatidylcholines / Q000008:administration & dosage*; D051381:Rats; D013154:Spleen / Q000378:metabolism
D001802:Blood Substitutes; D003692:Delayed-Action Preparations; D005466:Fluorocarbons; D010713:Phosphatidylcholines; D002784:Cholesterol