Effects of cimetidine, antipyrine, and pregnenolone carbonitrile on misonidazole pharmacokinetics.
We investigated the effects of cimetidine, antipyrine, and pregnenolone carbonitrile on the pharmacokinetics of misonidazole (MISO) in mice. antipyrine did not induce MISO demethylation. Considerable induction was seen with pregnenolone carbonitrile, but it was not superior to phenobarbital. Cimetidine inhibited MISO demethylation and increased its half-life and area under the curve. We suggest that patients receiving cimetidine and MISO have their MISO pharmacokinetics carefully monitored.
D000818:Animals; D000983:Antipyrine / Q000494:pharmacology*; D002927:Cimetidine / Q000494:pharmacology*; D004347:Drug Interactions; D006146:Guanidines / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008920:Misonidazole / Q000378:metabolism*; D009593:Nitroimidazoles / Q000378:metabolism*; D011285:Pregnenolone Carbonitrile / Q000494:pharmacology*
D006146:Guanidines; D009593:Nitroimidazoles; D011285:Pregnenolone Carbonitrile; D002927:Cimetidine; D008920:Misonidazole; D000983:Antipyrine