The effect of Fluosol-DA on pulmonary vessels.
The infusion of Fluosol-DA will increase the pulmonary artery pressure and the capillary wedge pressure as well as increase the cardiac output. The changes were more marked with the infusion of Fluosol-DA compared to whole blood, Hespander, or Saviosol. Calculated pulmonary vascular resistance decreased with Fluosol-DA infusion and lung water did not increase. We reconfirmed that during infusion of Fluosol-DA, PaO2 increased in many cases and the calculated shunt ratio decreased as a result.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D001802:Blood Substitutes / Q000494:pharmacology*; D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D005466:Fluorocarbons / Q000494:pharmacology*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives; D008168:Lung / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D001802:Blood Substitutes; D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination