title: Phase shifts in circadian rhythmicity of total, free corticosterone and transcortine plasma levels in hypothyroid male Japanese quails.
abstract: Control, radiothyroidectomized, and methimasol-treated short day (6L:18D; beginning of light at 0700) male Japanese quails were studied with regard to their circadian rhythmicity of total, free corticosterone and transcortine plasma level. In the controls, the peak of total and free corticosterone coincided with the maximal corticosterone binding capacity of transcortine; these parameters can be characterized by similar daily rhythm. In hypothyroid birds a synchronous phase shift of these parameters has been observed. In methimasol-treated animals the phase shift of the circadian rhythmicity was 6-8 hr, and in the radiothyroidectomized group 12 hr, respectively. According to the degree of hypothyroidism the metabolic clearance rate (MCR) of corticosterone decreased. This effect leads to the phase shift of total corticosterone rhythm, and the shift includes not only free, but also transcortine concentration.
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects; D003345:Corticosterone / Q000097:blood*; D003370:Coturnix / Q000097:blood*; D006207:Half-Life; D007037:Hypothyroidism / Q000097:blood* / Q000209:etiology; D008297:Male; D008713:Methimazole / Q000494:pharmacology; D011784:Quail / Q000097:blood*; D013965:Thyroidectomy; D013974:Thyroxine / Q000097:blood; D014156:Transcortin / Q000378:metabolism*
chemical_list: D008713:Methimazole; D014156:Transcortin; D013974:Thyroxine; D003345:Corticosterone