Effects of Urol on isolated neuromuscular preparations of guinea pig and rat urogenital tracts (ureter, detrusor vesicae and vas deferens).
Urol--a compound of extracts from rad. Rubiae, sem. Ammeos visnagae, herb. Virgaureae, rad. Taraxaci and aescin - induced changes in the mechanical activity (isotonic registration) of guinea pig and rat ureter, detrusor and vas deferens preparations when applied at concentrations of 10 ng to 100 microgram/ml. Low concentrations (10 ng to 1 microgram/ml) had an inhibitory effect on the spontaneous mechanical phasic activity in about half of the ureter preparations and a stimulatory effect on the remaining preparations; higher concentrations (1-100 microgram/ml) had a predominantly inhibitory effect. Urol acted similarly on detrusor preparations; it inhibited (up to 30% at 10 mg/ml) or stimulated the contractile responses after nerve stimulation (10 Hz, 0.3 ms, 3 s); it had a purely inhibitory effect on the contractions of vas deferens after nerve stimulation and had an inhibitory effect on X-ray-induced contractions in detrusor muscle preparations. The effects of Urol were observed at therapeutically relevant concentrations (about 1-10 microgram/ml). The nonuniform effects of Urol on urinary tract preparations suggest a reason for the differences in therapeutic response observed in clinical trials.
D000818:Animals; D004338:Drug Combinations / Q000494:pharmacology; D004928:Escin / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012503:Saponins / Q000494:pharmacology*; D014513:Ureter / Q000187:drug effects; D014566:Urogenital System / Q000187:drug effects*; D014649:Vas Deferens / Q000187:drug effects
D004338:Drug Combinations; D010936:Plant Extracts; D012503:Saponins; D004928:Escin; C013328:Urol (pharmaceutical)