title: Local immunity and Ostertagia circumcincta: changes in the gastric lymph of sheep after a primary infection.
abstract: Some aspects of the kinetics of the primary local immune response to O. circumcincta were studied by monitoring the flow and composition of gastric lymph from 4 sheep for 3 weeks after infection with 50 000 larvae. A significant increase in the frequency of lymphoblasts in the lymph showed that all the sheep were responding immunologically to the parasites from day 8 onwards. However, considerable individual variation in degree and timing was evident in other aspects of the immune response; 2 animals responded with large increases in lymphocyte output which reached a peak on day 5 or day 10, whereas the main response in the other 2 sheep appeared to be inflammatory in nature, with large increases in lymph flow and eosinophil output which occurred during the third week of infection. No significant changes in the content of IgA or IgA anti-worm antibody were detected in the lymph, but pepsinogen concentrations were significantly raised from day 12 onwards.
mesh_terms: D000818:Animals; D005260:Female; D007136:Immunoglobulins / Q000032:analysis; D008196:Lymph / Q000032:analysis / Q000166:cytology*; D008297:Male; D010029:Ostertagiasis / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology* / Q000473:pathology; D013270:Stomach; D014252:Trichostrongyloidiasis / Q000662:veterinary*
chemical_list: D007136:Immunoglobulins