Antibiotics from basidiomycetes. XVIII. Strobilurin C and oudemansin B, two new antifungal metabolites from Xerula species (Agaricales).
Two new antifungal (E)-beta-methoxyacrylates, strobilurin C and oudemansin B, were isolated from cultures of Xerula longipes and Xerula melanotricha. Their structures were elucidated by spectroscopic methods. Both antibiotics inhibit the growth of a wide variety of saprophytic and phytopathogenic fungi at very low concentrations. Like strobilurins A, B, and oudemansin A the new metabolites are potent inhibitors of respiration.
D000179:Acrylates / Q000302:isolation & purification; D000363:Agaricales / Q000032:analysis* / Q000254:growth & development; D000935:Antifungal Agents / Q000302:isolation & purification*; D001487:Basidiomycota / Q000254:growth & development*; D002942:Circular Dichroism; D005231:Fatty Acids, Unsaturated; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008689:Methacrylates; D008826:Microbial Sensitivity Tests; D013053:Spectrophotometry; D000073739:Strobilurins; D014631:Valerates / Q000302:isolation & purification
D000179:Acrylates; D000935:Antifungal Agents; D005231:Fatty Acids, Unsaturated; D008689:Methacrylates; D000073739:Strobilurins; D014631:Valerates; C023324:oudemansin; C038756:strobilurin C