Failure of oral versus parenteral corticosteroids in a case of acute inflammatory polyradiculoneuropathy (Guillain-Barré syndrome).
A case of acute inflammatory polyradioculoneuropathy (IPN, Guillain-Barré syndrome) not responding to oral corticosteroids but showing marked improvement on parenteral corticosteroids is reported. Oral prednisone 60 mg/day was begun on hospital admission and increased after one week to 100 mg/day; however, the patient's respiratory function, demonstrated by forced vital capacity, continued to deteriorate. Improvement was noted when the patient was switched to intravenous methyl-prednisolone 100 mg/day. Further attempts to use oral corticosteroids (including oral methyl-prednisolone 96 mg/day) resulted in deterioration of the patient's function.
D000284:Administration, Oral; D000293:Adolescent; D001682:Biological Availability; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000378:metabolism; D011129:Polyradiculoneuropathy / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage* / Q000378:metabolism
D011239:Prednisolone; D008775:Methylprednisolone