In vitro-activity of clavulanic acid and amoxicillin combined against amoxicillin-resistant bacteria.
The ability of clavulanic acid to inactivate beta-lactamase was investigated using 47 amoxicillin-resistant bacteria. In the presence of 10 mg/l clavulanic acid most strains of staphylococci, Escherichia coli, Klebsiella and Proteus mirabilis became fully amoxicillin-sensitive. This effect of clavulanic acid was in most instances not observed with Serratia marcescens, Proteus inconstans, Pseudomonas aeruginosa, Enterobacter and indole-positive Proteus species.
D000658:Amoxicillin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D019818:Clavulanic Acid; D004347:Drug Interactions; D007769:Lactams / Q000494:pharmacology; D010403:Penicillin Resistance
D000900:Anti-Bacterial Agents; D007769:Lactams; D019818:Clavulanic Acid; D000658:Amoxicillin