Vascular effects of vanadate.
The present experiments demonstrate that vanadate (sodium orthovanadate) given i.v. to anesthetized cats induces a marked, transient and reversible constriction of visceral arteries, including the renal artery, whereas the femoral and carotid artery escape constriction. The constriction of the renal artery is accompanied by a pronounced reduction of glomerular filtration rate and urine production. The vasoconstriction appears to be caused by a direct effect of vanadate on the vessel wall, but the mechanism of action is not established.
D000818:Animals; D001158:Arteries / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D004231:Diuresis / Q000187:drug effects; D011168:Portal System / Q000187:drug effects; D012077:Renal Artery / Q000187:drug effects; D014638:Vanadates; D014639:Vanadium / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects*
D014639:Vanadium; D014638:Vanadates