The protective effect of hymochromone against ethanol-induced thiamin deficiency.
Intragastric administration of ethanol to male rats given at 6 gm/kg body weight, daily for two weeks, produced no significant change in the body or liver weights. Hepatic total lipid increased but this was no more than a trend. Treatment with ethanol, however, resulted in a marked decrease in transketolase activity (TK) of the haemolysed whole blood, associated with a pronounced rise in the stimulating effect of thiamin pyrophosphate on this enzyme (TPP effect). These changes mediated by ethanol were counteracted by hymochromone.
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D000431:Ethanol / Q000037:antagonists & inhibitors*; D006923:Hymecromone / Q000494:pharmacology*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013832:Thiamine Deficiency / Q000139:chemically induced / Q000517:prevention & control*; D013835:Thiamine Pyrophosphate / Q000378:metabolism; D014174:Transketolase / Q000097:blood; D014468:Umbelliferones / Q000494:pharmacology*
D000975:Antioxidants; D014468:Umbelliferones; D000431:Ethanol; D006923:Hymecromone; D014174:Transketolase; D000469:Alkaline Phosphatase; D013835:Thiamine Pyrophosphate