Changes of urinary kallikrein and kinin excretions induced by adrenalin infusion in conscious dogs.
A subpressor dose of adrenalin (0.5 mg/h) infused intravenously into nine conscious trained dogs increased urine kinin excretion from 41 +/- 9 ng/h to 191 +/- 29 ng/h. The effect was abolished by phenoxybenzamin pretreatment (1 mg/kg). In alpha-blocked condition adrenalin increased urine TAMe-esterase activity from 12.7 +/0 2.3 mEU/h to 15.7 +/- 2.8 mEU/h whilst in beta-blocked condition the catecholamine decreased urine enzyme activity from 12.7 +/- 1.0 mEU/h to 11.7 +/- 1.1 mEU/h. Adrenalin invariably decreased urine sodium excretion. In comparable experiments with dopamin (1.0 mg/h) a slight natriuresis was observed, yet urine kallikrein and urine kinin excretions remained unmodified.
D000818:Animals; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology; D004837:Epinephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005260:Female; D007610:Kallikreins / Q000652:urine*; D007705:Kinins / Q000652:urine*; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012964:Sodium / Q000652:urine
D007705:Kinins; D010643:Phenoxybenzamine; D012964:Sodium; D011433:Propranolol; D007610:Kallikreins; D004298:Dopamine; D004837:Epinephrine