The moderation of elastase-induced emphysema in the hamster by intratracheal pretreatment or post-treatment with succinyl alanyl alanyl prolyl valine chloromethyl ketone.
The capacity of the synthetic elastase inhibitor, succinyl alanyl alanyl prolyl valine chloromethyl ketone (CMK), to moderate elastase-induced emphysema in hamsters was examined using morphometric and physiologic measurements. When 0.5 mg of CMK in saline was injected intratracheally 1 h before the intratracheal injection of 0.1 mg of porcine pancreatic elastase, the hamsters did not develop emphysema. When CMK was injected intratracheally 1 h after elastase, the severity of emphysema was reduced by approximately 50% compared with control animals receiving saline 1 h after elastase. The CMK was ineffective when administered intratracheally 4 h after elastase.
D000590:Amino Acid Chloromethyl Ketones / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D006224:Cricetinae; D004791:Enzyme Inhibitors; D007267:Injections; D008647:Mesocricetus; D010196:Pancreatic Elastase / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011656:Pulmonary Emphysema / Q000139:chemically induced / Q000201:enzymology*; D014132:Trachea
D000590:Amino Acid Chloromethyl Ketones; D004791:Enzyme Inhibitors; C031135:succinyl-alanyl-alanyl-prolyl-valine chloromethyl ketone; D010196:Pancreatic Elastase