Noncontact detection of experimental amelanotic ocular melanoma with L-3-123I-iodo-alpha-methyltyrosine.
An application of L-3-123I-iodo-alpha-methyltyrosine for the detection of ocular melanoma is presented. In rabbits with malignant Greene amelanotic melanoma transplanted to the anterior chamber of the eye, all tumors were detected in positive contrast using a gamma camera with a single pinhole collimator. The smallest tumor identified weighed 65 mg. Our data are compared with those obtained with 32PO4, 67Ga, 203Pb or labelled iodochloroquine.
D000818:Animals; D000867:Anterior Chamber; D005134:Eye Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging*; D008781:Methyltyrosines; D009374:Neoplasms, Experimental / Q000175:diagnosis; D011817:Rabbits; D011877:Radionuclide Imaging / Q000295:instrumentation
D008781:Methyltyrosines; C030855:3-iodo-alpha-methyltyrosine