Subtyping of properdin factor B (Bf) by isoelectrofocusing.
Properdin factor B (Bf) is a polymorphic protein in the human plasma. Two common alleles, BfS, BfF, and two rare alleles, BfF1, BfS1, have been demonstrated in Caucasians. We now report that BfF can be subtyped into two alleles, BfFa and BfFb by isoelectrofocusing. Family studies indicate that they are inherited in a co-dominant pattern. Gene frequencies for Caucasians are: BfS 0.808, BfF1 0.019, BfS1 0.005, BfFa 0.038 and BfFb 0.128.
D001315:Australia; D011415:Complement Factor B / Q000235:genetics*; D004587:Electrophoresis, Agar Gel; D004792:Enzyme Precursors / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007525:Isoelectric Focusing; D008297:Male; D044465:White People
D004792:Enzyme Precursors; D011415:Complement Factor B