[Clinical and experimental study of the effect of obsidan and hemiton on the blood kallikrein-kinin system].
In 52 patients with labile hypertension and also in experimental hypertension in 52 rats dynamics of kallikrein-kinin system in the blood during obsidan and hemiton treatment has been studied to find relationship between the hypotensive action of these drugs and the blood kinins activity. It was found that there exist counter-directional shifts in the kallikrein-kinin system of the blood as a result of treatment depending on their initial level. Adequate therapy contributed to the maintenance of optimum kinin concentration for preservation of homeostasis. With hypertensive syndrome supervening in rats increase of kinin predecessor synthesis has been recorded. Chronic administration of obsidan (0.5 mg/kg) and hemiton (0.1 mg/kg for 20 days increased kininogenesis).
D000293:Adolescent; D000328:Adult; D000818:Animals; D003000:Clonidine / Q000627:therapeutic use*; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy; D006978:Hypertension, Renovascular / Q000097:blood / Q000188:drug therapy; D007610:Kallikreins / Q000097:blood*; D007705:Kinins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use*; D051381:Rats
D007705:Kinins; D011433:Propranolol; D007610:Kallikreins; D003000:Clonidine
Kliniko-éksperimental'noe izuchenie vliianiia obzidana i gemitona na kallikrein-kininovuiu sistemu krovi.