Comparative sensitivity of Naegleria fowleri to amphotericin B and amphotericin B methyl ester.
Data presented showed that Naegleria fowleri is much more sensitive to amphotericin B (AmB) than to amphotericin B methyl ester (AME). In vitro, AME was effective at concentrations of 1.0 microgram/ml whereas the parent antibiotic, AmB, was effective at concentrations of 0.0125 to 0.025 microgram/ml. In vivo, AmB, at a concentration of 2.5 mg/kg/day, produced 100% survival in mice infected with N. fowleri, but AME failed to protect infected mice even at concentrations of 30 mg/kg/day. The results support previous observations with fungi which have shown that AmB is a more potent antimicrobial agent than AME.
D000656:Amoeba / Q000187:drug effects*; D000666:Amphotericin B / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008590:Meningoencephalitis / Q000188:drug therapy* / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D013997:Time Factors
C017501:methylamphotericin B; D000666:Amphotericin B