Participation of prostaglandins in the action of kinins on the central dopaminergic system in the rat. I. The action of kinins on the central dopaminergic system after pretreatment with indomethacin.
The effect of intraventricularly (ivc) administered bradykinin (BRS) and activation of kininogenic enzymes of the cerebral tissue by kallikrein on dopaminergic system was investigated in tests of amphetamine (AMPH) and apomorphine (APO)-induced stereotypy and haloperidol (HAL)-induced catalepsy in rats receiving an inhibitor of prostaglandin synthetase, indomethacin (IND). The cerebral content of dopamine (DA), noradrenaline (NA) and homovanillic acid (HVA) was determined after some dosage schedules. In rats pretreated with IND the action of AMPH was potentiated and modulated by kinins (depending on the dose). IND prolonged the duration of APO-induced stereotypy and antagonized the action of low dose (1 mu g) of BRS, but potentiated the action of high doses (2 and 4 mu g) of BRS. IND potentiated the action of BRS on catalepsy induced by a low dose of HAL (0.75 mg/kg) but abolished the action of BRS on the catalepsy produced by a high dose of HAL (1.25 mg/kg). The results of biochemical investigation do not explain in full the behavioral changes.
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D004347:Drug Interactions; D006719:Homovanillic Acid / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology; D007610:Kallikreins / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D011292:Premedication; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism*
D011954:Receptors, Dopamine; D007610:Kallikreins; D001920:Bradykinin; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid; D007213:Indomethacin