HLA haplotypes and long survival in childhood acute lymphoblastic leukaemia treated with transfer factor.
Association between HLA haplotypes and long survival was investigated in 116 children with acute lymphoblastic leukaemia. It was found that patients with A2 B12 and/or A2 B40 haplotypes survived longer than patients wtihout these two haplotypes. Since all children were treated with transfer factor obtained from their relatives, it is suggested that children possessing A2 B12 or A2 B40 haplotypes may respond better to this type of immunotherapy.
D000208:Acute Disease; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D006238:Haploidy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology; D008297:Male; D011379:Prognosis; D013997:Time Factors; D014165:Transfer Factor / Q000627:therapeutic use*
D006680:HLA Antigens; D014165:Transfer Factor