An analysis of the choleretic effects of infusions of sodium cholate in the guinea-pig.
The choleretic effects of infusions of sodium cholate, with and without the simultaneous infusion of taurine was compared with the choleretic effect of infusions of sodium taurocholate at rates ranging from 20--70 nmole/min. g. liver in anaesthetized guinea-pigs. Sodium cholate was secreted in bile mainly conjugated with taurine and with glycine. 10% was secreted unconjugated. Not more than 10% of the total bile salts secreted may have undergone reduction at C-3. The increase in bile flow with sodium cholate was generally greater than that with sodium taurocholate. The additional flow could not be correlated with the presence of glycocholate or free cholate in bile, and may be due to an action of cholate on biliary secretory mechanisms before the bile salt is secreted into the canaliculi.
D000818:Animals; D001646:Bile / Q000502:physiology*; D002793:Cholic Acids / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006168:Guinea Pigs; D008297:Male; D008433:Mathematics; D008823:Micelles; D013654:Taurine / Q000494:pharmacology; D013656:Taurocholic Acid / Q000494:pharmacology*
D002793:Cholic Acids; D008823:Micelles; D013654:Taurine; D013656:Taurocholic Acid