Time-action profile of zinc human insulin (recombinant DNA) in young volunteers as compared with zinc porcine insulin (Monotard).
Zinc human insulin (recombinant DNA) or zinc PPI (Monotard) 20 U was injected subcutaneously to study the time-action profile in six healthy volunteers. During the test period they received a 10-g biscuit containing 3% moisture, 7% protein, 10% fat, 80% carbohydrate, and 30 ml of water every hour. The onset of action with zinc human insulin occurred earlier than with zinc PPI. Also, the intensity of the blood sugar-lowering effect was more pronounced 3 and 4 h after administration of insulin. No other statistically significant differences were detected between the two blood glucose curves. The results show that it is possible to develop a zinc human insulin formulation with a duration of the blood sugar-lowering effect equal to a zinc PPI formulation.
D000328:Adult; D000818:Animals; D001786:Blood Glucose; D006801:Humans; D049528:Insulin, Long-Acting / Q000494:pharmacology*; D011897:Random Allocation; D011994:Recombinant Proteins / Q000494:pharmacology; D013552:Swine
D001786:Blood Glucose; D049528:Insulin, Long-Acting; D011994:Recombinant Proteins