Destruction of human solid tumors by alkyl lysophospholipids.
Alkyl lysophospholipids (ALP) are synthetic analogs of the naturally occurring 2-lysophosphatidylcholine. The effect of ALP on the proliferation of 22 different gynecologic malignant tumors in humans was studied in vitro. ALP caused progressive death of tumor cells over 24-96 hours. In addition, tumor specimens from the tested human tumors were xenotransplanted into NMRI nude mice. ALP induced a highly significant retardation of the in vivo growing human tumors. Neither oral nor iv administration of these compounds caused any recognizable side effects.
D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D002277:Carcinoma / Q000188:drug therapy; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy*; D006801:Humans; D066298:In Vitro Techniques; D008244:Lysophosphatidylcholines / Q000627:therapeutic use*; D008246:Lysophospholipids; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010051:Ovarian Neoplasms / Q000188:drug therapy; D010743:Phospholipids / Q000627:therapeutic use*; D012509:Sarcoma / Q000188:drug therapy; D013724:Teratoma / Q000188:drug therapy; D014183:Transplantation, Heterologous; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy; D014594:Uterine Neoplasms / Q000188:drug therapy
D008244:Lysophosphatidylcholines; D008246:Lysophospholipids; D010743:Phospholipids