Inhibitory effect of pancreatic elastase on thickening of the renal glomerular basement membrane in the spontaneously diabetic rat.
Effect of pork pancreatic elastase on thickening of the renal glomerular basement membrane was studied in three litter mates of the spontaneously diabetic rats by electron microscopic morphometry. Intramuscular injection of physiologic saline solution or elastase solution (5 mg/kg body weight/day) was repeated daily for 30 days. Renal cortex specimens were obtained before and after the injection in two litter mates. Renal glomerular basement membrane thickness (RGBMT) of the rats injected with saline increased markedly, whereas RGBMT of the rats treated with elastase remained close to the initial value. In each of the three litter mates, RGBMT after the treatment was significantly thinner in the elastase injected rats than in the saline injected rats.
D000818:Animals; D001485:Basement Membrane / Q000473:pathology; D003920:Diabetes Mellitus / Q000473:pathology*; D005951:Glucose Tolerance Test; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology*; D008297:Male; D010196:Pancreatic Elastase / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D010196:Pancreatic Elastase