[Effects of subacute treatment with clomiphene, ethamoxytriphetol (Mer-25), and nafoxidine on blood calcium and bone density in rats].
The authors study the effect of clomiphene, ethamoxytriphetol and nafoxidine on calcemia and bone density of the rat. These antiestrogens induce hypercalcemia, reproducing the bone radiologic changes produced after castration. The different effects obtained in normal and ovariectomized rats are probably due to the small estrogenic activity of antiestrogens.
D000818:Animals; D001842:Bone and Bones / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000187:drug effects*; D002118:Calcium / Q000097:blood*; D002369:Castration; D002996:Clomiphene / Q000494:pharmacology*; D004965:Estrogen Antagonists / Q000494:pharmacology*; D004978:Ethamoxytriphetol / Q000494:pharmacology*; D000431:Ethanol / Q000031:analogs & derivatives*; D005260:Female; D009256:Nafoxidine / Q000494:pharmacology*; D009929:Organ Size; D011759:Pyrrolidines / Q000494:pharmacology*; D011859:Radiography; D051381:Rats; D011919:Rats, Inbred Strains
D004965:Estrogen Antagonists; D011759:Pyrrolidines; D002996:Clomiphene; D000431:Ethanol; D009256:Nafoxidine; D004978:Ethamoxytriphetol; D002118:Calcium
Effectos del tratamiento subagudo con clomifeno, etamoxitrifetol (MER-25) y nafoxidina sobre la calcemia y densidad osea en ratas.