Carcinogenicity of deuterium-labeled N-nitroso-N-methylcyclohexylamine in rats.
F344 rats were treated with both unlabeled N-nitroso-N-methylcyclohexylamine (NMC) and deuterium-labeled NMC (NMC-d3) in the methyl group. Both compounds were administered in the drinking water at concentrations of 50 and 12.5 mg/liter. The NMC-d3 was not less carcinogenic than the unlabeled NMC, which suggested that oxidation of the methyl group is not a rate-limiting step in the induction of esophageal tumors.
D000818:Animals; D002273:Carcinogens; D003514:Cyclohexylamines / Q000378:metabolism / Q000633:toxicity*; D003903:Deuterium; D004938:Esophageal Neoplasms / Q000139:chemically induced*; D005260:Female; D008745:Methylation; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344
D002273:Carcinogens; D003514:Cyclohexylamines; D009602:Nitrosamines; D003903:Deuterium; C025137:N-nitroso-N-methylcyclohexylamine