[Antitumor spectrum of aclacinomycin A, MA 144 N 1 and MA 144 S 1 on the rat ascitic hepatoma (author's transl)].
Antitumor activity of new anthracycline antibiotics aclacinomycin A, MA 144 N1 and MA 144 S 1 was studied on 11 cell lines of ascitic hepatoma in Donryu rats. These compounds showed similar antitumor spectrum against AH hepatoma; moderate effect on AH 13, 44, 66, 66F, 7974 and 60 C in the ip inoculation-ip treatment system. Aclacinomycin A showed a marked antitumor effect on AH 41 C in the iv-iv system, and AH 44 in the iv-ip and iv-po systems. The antitumor spectrum of aclacinomycin A seems to be different from that of adriamycin.
D015250:Aclarubicin / Q000031:analogs & derivatives; D000818:Animals; D004353:Drug Evaluation, Preclinical; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D009279:Naphthacenes / Q000008:administration & dosage / Q000627:therapeutic use; D051381:Rats
D009279:Naphthacenes; C011157:aclacinomycins; D015250:Aclarubicin