5-Hydroxytryptamine uptake by lungs of hamsters with pulmonary emphysema.
Elastase-induced emphysema in hamsters was used as a model to determine whether this type of chronic lung injury affected the metabolic function of pulmonary endothelium. 5-Hydroxytryptamine (5-HT) uptake was studied in isolated perfused lungs of hamsters from a control group and from those with emphysema of various severity. After measuring 5-HT uptake, we determined the mean linear intercept and internal surface area for each lung. The concentration of 5-HT used in the perfusate ranged from the level in the resting hamster to supraphysiologic levels. The results reveal that elastase-induced emphysema does not affect 5-HT uptake by the isolated perfused hamster lung despite significant loss of alveolar surface area.
D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D004727:Endothelium / Q000378:metabolism; D008168:Lung / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D010196:Pancreatic Elastase / Q000494:pharmacology; D011656:Pulmonary Emphysema / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D010196:Pancreatic Elastase