Linkage disequilibria between HLA-B and the rarer properdin factor B alleles, BfF1 and BfS1.
Phenotypic association and highly significant linkage disequilibria have been demonstrated for HLA-B18 and BfF1 and HLA-Bw50 and BfS1 alleles among Caucasians from Australia and the United States (San Francisco Bay area). The HLA-B18, BfF1 association appears to be associated with HLA-Aw30. It is possible that BfS1 arose as a mutation, after the evolutionary splitting of HLA-Bw21, on an HLA-Bw50 haplotype, and that BfF1 arose on an HLA-Aw30, B18 haplotype.
D000483:Alleles; D001315:Australia; D011415:Complement Factor B / Q000235:genetics*; D004792:Enzyme Precursors / Q000235:genetics*; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D006238:Haploidy; D006801:Humans; D010641:Phenotype; D014481:United States
D004792:Enzyme Precursors; D006680:HLA Antigens; D011415:Complement Factor B