Associations of properdin factor B with melanoma.
We investigated 98 melanoma patients and 135 normal controls for differences in phenotype and genotype frequencies at the properdin factor B locus. A significant negative association with the Bf-F allele and melanoma was found, resulting in an estimated relative risk of 0.5. The estimated relative risk for developing melanoma among people with the Bf-FF genotype is 0.07. The Bf-S phenotype was significantly increased among the melanoma sample, with an estimated risk of 6.5. The data suggest association of the Bf locus with a melanoma protection and/or susceptibility gene(s).
D011415:Complement Factor B / Q000235:genetics*; D004792:Enzyme Precursors / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008285:Major Histocompatibility Complex; D008545:Melanoma / Q000235:genetics*; D010641:Phenotype; D012306:Risk; D012878:Skin Neoplasms / Q000235:genetics*
D004792:Enzyme Precursors; D011415:Complement Factor B