Role of dopamine in the diuresis caused by stimulation of atrial receptors.
The diuretic response to stimulation of left atrial receptors, by distending balloons located either at the pulmonary vein-left atrial junctions or in the body of the left atrium was studied during blockade of dopamine receptors using a continuous infusion o sulpiride in doses ranging from 0.632 to 5.153 mumol . kg-1 . min-1, in anaesthetized dogs. A diuretic response was obtained in each experiment of distension of the balloons: the response was similar to that observed in dogs without blockade of dopamine receptors and was not significantly related to the dose os sulpiride used. It is concluded that the diuretic response to stimulation of atrial receptors, known to be mediated by a blood-borne agent, is unlikely to be caused by dopamine.
D000818:Animals; D004231:Diuresis; D004285:Dogs; D004298:Dopamine / Q000502:physiology*; D006325:Heart Atria / Q000294:innervation*; D008465:Mechanoreceptors / Q000502:physiology*; D009318:Natriuresis; D010812:Physical Stimulation; D011954:Receptors, Dopamine / Q000187:drug effects; D013469:Sulpiride / Q000494:pharmacology
D011954:Receptors, Dopamine; D013469:Sulpiride; D004298:Dopamine