Does a renal vasodilator system mediate racial differences in essential hypertension?
Clinical and epidemiologic data support the contention that black people have a higher incidence and severity of essential hypertension than white people, a phenomenon which is likely due to genetic factors. Physiologic profiles in such patients reveal a striking prevalence of low renin, volume-expanded hypertension, with an exaggerated propensity to sodium retention. A deficiency in the natriuretic, vasodilatory renal kallikrein-kinin system may explain these phenomena and may be of practical importance in the selection of therapy.
D044383:Black People; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D007610:Kallikreins / Q000652:urine; D007668:Kidney / Q000098:blood supply*; D014666:Vasomotor System / Q000503:physiopathology
D007610:Kallikreins