The depressive action of ammonium chloride on the hepatic blood flow in sheep.
Using the 133Xe clearance method it is shown that NH4Cl infusion into the anterior mesenteric vein decreased capillary blood flow in the liver. Phentolamine completely and propranolol partially prevented the depressive action of NH4Cl on hepatic blood flow. NH5Cl infused into the jugular vein provoked a slight increase in the hepatic blood flow. The adrenaline-like action of ammonium ion on the blood circulation in the liver region is discussed.
D000643:Ammonium Chloride / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D002196:Capillaries / Q000502:physiology; D003864:Depression, Chemical; D008099:Liver / Q000098:blood supply*; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D012756:Sheep / Q000502:physiology*
D000643:Ammonium Chloride; D011433:Propranolol; D010646:Phentolamine