The localization of kallikrein in the dog and guinea-pig submandibular glands.
In the dog and guinea-pig submandibular glands kallikrein seems to be present in the striated duct cells. Following sympathetic nerve and in vivo isoproterenol stimulation of the dog and guinea-pig submandibular gland respectively, there is a reduction of kallikrein concentration. Ultrastructurally this reduction corresponds to the decrease of straited duct secretory granules in both species. Parasympathetic stimulation also causes some release of kallikrein from both species.
D000818:Animals; D003594:Cytoplasmic Granules / Q000187:drug effects; D004285:Dogs; D004558:Electric Stimulation; D006168:Guinea Pigs; D007545:Isoproterenol / Q000494:pharmacology; D007610:Kallikreins / Q000378:metabolism*; D008297:Male; D008854:Microscopy, Electron; D010275:Parasympathetic Nervous System / Q000502:physiology; D010862:Pilocarpine / Q000494:pharmacology; D013363:Submandibular Gland / Q000294:innervation / Q000378:metabolism* / Q000648:ultrastructure; D013564:Sympathetic Nervous System / Q000502:physiology
D010862:Pilocarpine; D007610:Kallikreins; D007545:Isoproterenol