Chronic myelocytic leukemia: eosinophils involved in the malignant clone.
Chronic myelocytic leukemia (CML) is a clonal disorder involving neutrophil, monocyte, erythrocyte, and platelet precursors. In order to determine if the eosinophils are also involved in the leukemic clone, we purified the eosinophils from a woman heterozygous for the common electrophoretic variants of the G6PD gene. Only type B enzyme was demonstrable in the eosinophils, neutrophils, and red cells, but both A and B enzymes were found in the fibroblasts. The data provide evidence that the eosinophil is involved in the malignant clone.
D000328:Adult; D002469:Cell Separation; D002904:Chromosomes, Human, 21-22 and Y; D002999:Clone Cells; D004804:Eosinophils; D005260:Female; D005347:Fibroblasts / Q000201:enzymology; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D006412:Hematopoietic Stem Cells / Q000201:enzymology; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood*
D005954:Glucosephosphate Dehydrogenase