Expression in fibroblast culture of the satellited-X chromosome associated with familial sex-linked mental retardation.
The satellited-X chromosome previously shown in lymphocyte culture to be associated with certain types of sex-linked mental retardation has, for the first time, been demonstrated in cultured skin fibroblasts and lymphocytes from two affected males and an obligate carrier female. These findings provide a basis for reliable diagnosis of female carriers and for the development of prenatal diagnosis.
D000328:Adult; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D005260:Female; D005347:Fibroblasts / Q000648:ultrastructure*; D006580:Genetic Carrier Screening; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D011296:Prenatal Diagnosis; D012730:Sex Chromosomes; D012867:Skin / Q000166:cytology; D014960:X Chromosome
D005819:Genetic Markers