Effects of orthovanadate on salt and water effluxes from the gills of seawater eels, Anguilla anguilla.
Orthovanadate (5 . 10(-7) M) perfused through isolated gills at a constant rate increased the perfusion pressure by 40% but inhibited the effluxes of Na+ and Cl- by 40%. Water efflux was unaltered. Ouabain (10(-4) M) and rotenone (10(-4) M) influenced salt and water effluxes in the same way but did not alter perfusion pressures. Orthovanadate (10(-5) M) perfused at constant rate increased the pressure nearly 2.5-fold; under these conditions effluxes of Na+, Cl- and H2O were all increased approximately 2.5-fold.
D000811:Anguilla; D000818:Animals; D002712:Chlorides / Q000378:metabolism; D005880:Gills / Q000187:drug effects / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology; D012402:Rotenone / Q000494:pharmacology; D012623:Seawater; D012964:Sodium / Q000378:metabolism; D012965:Sodium Chloride / Q000378:metabolism*; D014638:Vanadates; D014639:Vanadium / Q000494:pharmacology*; D014867:Water / Q000378:metabolism*
D002712:Chlorides; D014639:Vanadium; D012402:Rotenone; D014867:Water; D014638:Vanadates; D012965:Sodium Chloride; D010042:Ouabain; D012964:Sodium