A case report of basal cell adenoma showing elastic fiber (elastin-basement membrane complex) formation of the submandibular gland.
A biopsy case of basal cell adenoma of the submandibular gland was reported in a 15-year-old boy. The tumor was pigeon's egg-sized, spherical in shape and encapsulated by fibrous tissue, and its cut-surface was grayish white. Histologic feature of this neoplasm was a trabecular or tubular monomorphic adenoma with well-developed elastic fibers (elastin-basement membrane complex) in the interstitial tissue. Electron microscopy disclosed 4 kinds of tumor cells, that is, secreting cells, squamous cell-like cells with tonofibrils and tonofilaments, clear cells with a few filaments, and myoepithelial cells. The interstitium contained elastin, collagen fibrils and basement membrane-like substance. Possible production of elastic fibers by the myoepithelial cells of this adenoma was discussed.
D000236:Adenoma / Q000473:pathology*; D000293:Adolescent; D001485:Basement Membrane; D006801:Humans; D008297:Male; D010196:Pancreatic Elastase; D012468:Salivary Gland Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D013363:Submandibular Gland / Q000473:pathology*
D010196:Pancreatic Elastase