Effect of a specific 5HT uptake inhibitor (citalopram) on drug accumulation by rat lung slices.
Rat lung slices were used to examine the effects of citalopram, a compound reported to be a specific inhibitor of neuronal uptake of 5-hydroxytryptamine (5HT), on the pulmonary accumulation of 5HT, noradrenaline (NA), imipramine (IP) and paraquat (PQ). 5 X 10(-9) mol/l citalopram inhibited 5HT uptake by 30-40% but NA uptake was not affected at any of the concentrations of citalopram studied. At the highest concentrations of citalopram (10(-5) to 10(-4) mol/l) the accumulation of IP and PQ was reduced by25-30%. It is concluded that at low concentrations, citalopram is a specific and potent inhibitor of 5HT uptake by rat lung slices.
D000818:Animals; D001572:Benzofurans / Q000494:pharmacology*; D015283:Citalopram; D007099:Imipramine / Q000378:metabolism; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D010269:Paraquat / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000494:pharmacology*
D001572:Benzofurans; D004364:Pharmaceutical Preparations; D011437:Propylamines; D012702:Serotonin Antagonists; D015283:Citalopram; D012701:Serotonin; D007099:Imipramine; D010269:Paraquat; D009638:Norepinephrine