In vivo cytogenetic effects of oil shale retort process waters.
The induction of cytogenetic effects by oil shale retort process waters from 3 types of pilot plant retorts were examined in murine bone marrow. Each of the process waters induced increased frequencies of structural aberrations in mice treated with 3 daily intraperitoneal injections of the waters. The same treatment had no effect on the frequency of sister chromatid exchanges. Mice given a 1% solution of an above-ground retort water ad libitum for 8 weeks consumed about 1 ml/kg per day of the process water and had a frequency of aberrations comparable to mice given the same dose intraperitoneally for 3 days. Transplacental exposure of C3H mouse embryos indicated that clastogenic compounds in the above-ground retort process water can cross the placenta and induce chromosomal aberrations in embryonic tissues.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D005260:Female; D007220:Industrial Waste; D007928:Lethal Dose 50; D008297:Male; D008431:Maternal-Fetal Exchange; D051379:Mice; D008809:Mice, Inbred C3H; D011247:Pregnancy; D012722:Sewage; D014865:Waste Disposal, Fluid; D014877:Water Pollution, Chemical
D007220:Industrial Waste; D012722:Sewage