[Diminution of the rate of growth of HeLa cells caused by thioproline (Tp) and 2-aminothiazoline HCl (2-AT). Effect of L-proline].
Some aspects of the effect of thioproline and 2-amino-thiazoline-HCl on HeLa cell cultures are studied. Both drugs, at 1 mM concentrations, produce morphological changes that become stabilized after four days. The morphology changes depend on the microtubules, microfilaments, and de novo protein synthesis. Both drugs diminish the growth rate of HeLa cells, the effect being partially reverted by high concentrations (2 mM) of L-proline.
D006131:Growth Inhibitors / Q000494:pharmacology*; D006367:HeLa Cells / Q000187:drug effects / Q000473:pathology; D006801:Humans; D011392:Proline / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*; D053778:Thiazolidines
D006131:Growth Inhibitors; D013844:Thiazoles; D053778:Thiazolidines; C031363:2-aminothiazoline; D011392:Proline; C003438:thiazolidine-4-carboxylic acid
Disminución de la velocidad de crecimiento de células HeLa causada por tioprolina (Tp) y 2-amino-tiazolina-HCl (2-AT). Efecto de L-prolina.