Cholesteryl esters are bound by a peptide-initiation and a peptide-elongation factor.
Significantly higher quantities of cholesteryl 14-methylhexadecanoate than of cholesteryl laurate and cholesteryl palmitate are bound by a homogeneous peptide-initiation factor and purified peptide-elongation factor 1. Cholesteryl 14-methylhexadecanoate may function as a specific allosteric modifier changing the conformation of protein synthesis factors and thus modulating the activity of their binding sites.
D001665:Binding Sites; D002788:Cholesterol Esters / Q000378:metabolism*; D002850:Chromatography, Gel; D046911:Macromolecular Substances; D010445:Peptide Elongation Factors / Q000378:metabolism*; D010448:Peptide Initiation Factors / Q000378:metabolism*; D011485:Protein Binding; D011487:Protein Conformation; D012346:RNA, Transfer, Amino Acyl
D002788:Cholesterol Esters; D046911:Macromolecular Substances; D010445:Peptide Elongation Factors; D010448:Peptide Initiation Factors; D012346:RNA, Transfer, Amino Acyl