The aminoacyl-tRNA population of human reticulocytes.
The aminoacyl-tRNA population of human reticulocytes has been examined. These studies include: 1) determination of the levels of amino acid acceptance for 20 aminoacyl-tRNAs; 2) comparison of 20 aminoacyl-tRNAs from human reticulocytes to those of rabbit reticulocytes by reverse phase chromatography; 3) comparison of the levels of Ile- and Leu-tRNAs in fetal and adult reticulocytes; and 4) determination of the codon recognition properties of human Ala-, Asn-, His-, Leu-, Thr-, and Val-tRNAs. These studies provide evidence that the aminoacyl-tRNA population of human reticulocytes is adapted to the requirements of protein synthesis.
D000328:Adult; D000375:Aging; D000596:Amino Acids / Q000097:blood; D000818:Animals; D006801:Humans; D007231:Infant, Newborn; D014176:Protein Biosynthesis; D012346:RNA, Transfer, Amino Acyl / Q000097:blood*; D011817:Rabbits; D012156:Reticulocytes / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism; D013045:Species Specificity
D000596:Amino Acids; D012346:RNA, Transfer, Amino Acyl