Choline accumulation by photoreceptor cells of the rabbit retina.
Photoreceptor cells of the rabbit retina accumulate choline from the extracellular environment by an overall process that has a high affinity for choline. These cells do not synthesize acetylcholine; instead, the choline taken up is incorporated into phosphorylcholine and eventually phospholipid. A mechanism for efficient choline accumulation is presumably concomitant to the photoreceptor cell's synthesis of large amounts of membrane for outer segment membrane renewal. Its existence in the photoreceptor cell supports previous evidence that high-affinity choline uptake is not confined to neurons that release acetylcholine, but may be present wherever large amounts of choline are required.
D000109:Acetylcholine / Q000096:biosynthesis; D000818:Animals; D001692:Biological Transport; D002794:Choline / Q000378:metabolism*; D007700:Kinetics; D010767:Phosphorylcholine / Q000378:metabolism; D011817:Rabbits; D012160:Retina / Q000378:metabolism*
D010767:Phosphorylcholine; D002794:Choline; D000109:Acetylcholine