[In vitro culture of granulopoietic precursors in dysmyelopoiesis. Prognostic value (author's transl)].
96 patients with a dysmyelopoiesis have had an in vitro study of bone marrow CFUc at the time of diagnosis. A correlation between in vitro growth characteristics and the transformation in acute leukemia (AT) was searched. We found 5 types of in vitro growth: 3 with a "non-leukemic" pattern IA, IB, and IC, and 2 with a "leukemic" pattern II and III. In the type IA (normal growth) there is few death (16%), all without AT. In the types IB and ic with decreased in vitro growth, 40% of patients dead without an at and 25% after an AT. In the types II (with excess of clusters) and III (clusters without colonies) an AT was almost the case. The specificity, the positive and negative predictive values of in vitro growth type for the study of an AT outcome were the best of all that we obtained in the study of biological parameters in the dysmyelopoiesis. The study of bone marrow CFUc in dysmyelopoiesis can separate a group of patients with high risk of an AT outcome, which could be ameliorate with chimiotherapy.
D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000473:pathology; D000756:Anemia, Sideroblastic / Q000473:pathology; D002455:Cell Division; D002478:Cells, Cultured; D005260:Female; D006402:Hematologic Diseases / Q000473:pathology*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000473:pathology*; D006801:Humans; D007951:Leukemia, Myeloid / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011289:Preleukemia / Q000473:pathology*; D011379:Prognosis
Culture in vitro des progéniteurs granuleux dans les dysmyélopoïèses. Intèrêt pour le pronostic.