The participation of prostaglandins in the action of kinins on the central dopaminergic system in the rat. III. Participation of PGE1 in the action of kinins on the central dopaminergic system.
Prostaglandin E1 (PGE1) slightly inhibited the amphetamine (AMPH) induced stereotypy after administration of bradykinin (BRS) or stimulation the activity of kininogenic enzymes of the cerebral tissue by kallikrein administration. After administration of PGE1, BRS did not affect the apomorphine (APO)-induced stereotypy. The effect of kinins on catalepsy induced by haloperidol (HAL) was changed depending on the dose of PGE1. PGE1 given in combination with BRS increased the NA turnover in the rat striatum in comparison with the group receiving BRS, and given together with BRS and APO depressed the NA turnover in comparison with the group BRS and APO. A combined administration of PGE1 and BRS did not change the DA and HVA content under the experimental conditions used.
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D004347:Drug Interactions; D006719:Homovanillic Acid / Q000378:metabolism; D007610:Kallikreins / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism*
D011459:Prostaglandins E, Synthetic; D011954:Receptors, Dopamine; D007610:Kallikreins; D001920:Bradykinin; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid