Arginase and kallikrein activities as biochemical indices of occupational exposure to lead.
In a group of 60 workers occupationally exposed to lead the blood and urine lead concentrations, haematocrit, ALA-D and arginase activities, and urinary 5-aminolaevulinic acid (ALA) and coproporphyrin concentrations, and kallikrein activity were determined. Correlation coefficients of -0.78 and 0.77 for Pb-B/ALA and Pb-B/arginase were found respectively for lead concentrations above 40 microgram/dl blood, and 0.83, 0.76, 0.74, and -0.64 for Pb-U/ALA, Pb-U/Cp-U, Pb-U/kallikrein, and Pb.U/kallikrein, respectively. It seems that the increase in serum arginase activity may be indicative of liver damage while the decrease in kallikrein activity may indicate kidney damage in workers exposed to lead.
D000622:Aminolevulinic Acid / Q000652:urine; D001119:Arginase / Q000097:blood*; D003306:Coproporphyrins / Q000652:urine; D004781:Environmental Exposure; D006801:Humans; D007610:Kallikreins / Q000652:urine*; D007854:Lead / Q000009:adverse effects* / Q000097:blood / Q000652:urine; D009787:Occupational Medicine; D000623:Porphobilinogen Synthase / Q000097:blood
D003306:Coproporphyrins; D007854:Lead; D000622:Aminolevulinic Acid; D007610:Kallikreins; D001119:Arginase; D000623:Porphobilinogen Synthase