[Electrophysiologic investigations in a family with malignant hyperthermia (author's transl)].
The value of the quantitative electromyogram in the detection of subclinical myopathic signs was tested in a family consisting of 11 members, one of them showing a Malignant Hyperthermia crisis. Furtheron an in vitro contracture test and an ATP-test was performed and the Serum CPK and the isoenzyme in serum and muscle examined. The following conclusions were taken: 1) Although unspecific pattern (in 5 cases more than 12% polyphasic potentials were found, one of them showing a reduction of the mean duration of 30%) the electromyography is a good but not absolutely certain indicator of subclinical myopathic signs in Malignant Hyperthermia. 2) The exclusion of M.H. risk is not possible using a single test. 3) The diagnostic value of not invasive methods, as the electromyography is of special importance. The diagnostic use of many M.H. tests seems necessary.
D000293:Adolescent; D000328:Adult; D002648:Child; D003402:Creatine Kinase / Q000097:blood; D004576:Electromyography; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008305:Malignant Hyperthermia / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D008875:Middle Aged; D009119:Muscle Contraction; D009132:Muscles / Q000201:enzymology; D009431:Neural Conduction; D012306:Risk
D007527:Isoenzymes; D003402:Creatine Kinase
Elektrophysiologische Untersuchungen bei einer Familie mit maligner Hyperthermie.