Study of the carcinogenicity of large doses of dimethylnitramine, N-nitroso-L-proline, and sodium nitrite administered in drinking water to rats.
Large doses of dimethylnitramine (DMNM), N-nitroso-L-proline (NPRO), and sodium nitrite were administered in the drinking water to MRC Wistar rats for at least 1 year, and the rats were maintained for life. DMNM (total dose, 20 g/kg) produced liver tumors in 25 (69%) of the 36 rats and nasal cavity tumors in 9 (25%) of the rats. NPRO (total dose, 36 g/kg) induced no tumors in 37 treated rats. In the group receiving NaNO2 (3.0 g/liter drinking water; total dose, 63 g/kg), 8 (18%) of 45 rats had forestomach squamous papillomas. The tumor incidence in the NaNO2-treated group was significantly greater than that of 2% in a control group started 11 months earlier, which suggested that the NaNO2 was tumorigenic in this experiment.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D004123:Dimethylamines; D004305:Dose-Response Relationship, Drug; D005260:Female; D007928:Lethal Dose 50; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000139:chemically induced; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology*; D009573:Nitrites / Q000008:administration & dosage; D009574:Nitro Compounds; D009602:Nitrosamines; D011392:Proline / Q000031:analogs & derivatives*; D051381:Rats; D013274:Stomach Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D004123:Dimethylamines; D009573:Nitrites; D009574:Nitro Compounds; D009602:Nitrosamines; D011392:Proline; C010259:nitrosoproline; C013962:dimethylnitramine