Autoradiographic investigation of dentin production in rat incisors after vincristine administration.
0.7 mg/kg VCR was administered intravenously to nine rats in three experimental groups. One hour after VCR injection the animals were injected with 3H-proline. The animals were sacrificed 1.5, 5 and 24 h after the VCR administration, and by comparison with nine control animals similarly injected with sodium chloride solution and 3H-proline, it was shown that VCR causes an early, intracellular retention of labeled proline in the odontoblasts, an abnormal intracellular distribution of labeled material and a generally decreased secretion of dentinal matrix from the odontoblasts in the maxillary incisors. The severity of the effects were shown to vary in different parts of the incisors.
D000818:Animals; D001345:Autoradiography; D003094:Collagen / Q000378:metabolism; D003804:Dentin / Q000187:drug effects* / Q000502:physiology; D003810:Dentinogenesis / Q000187:drug effects*; D005260:Female; D007180:Incisor / Q000187:drug effects* / Q000502:physiology; D009804:Odontoblasts / Q000166:cytology / Q000187:drug effects; D011392:Proline; D051381:Rats; D014316:Tritium; D014750:Vincristine / Q000494:pharmacology*
D014316:Tritium; D014750:Vincristine; D003094:Collagen; D011392:Proline