Bu-2313, a new antibiotic complex active against anaerobes. I. Production, isolation and properties of Bu-2313 A and B.
An unidentified oligosporic actinomycete strain, No. E864-61, produced two new antibiotics, Bu-2313 A (C27H35NO9) and Bu-2313 B (C26H33NO9). Bu-2313 A and B each exhibited a broad antibiotic spectrum against Gram-positive and Gram-negative anaerobic bacteria, and showed in vivo activity against experimental infections produced by B. fragilis and C. perfringens. Bu-2313 also inhibited some aerobic bacteria such as streptococci. Bu-2313 B was approximately two-fold more active than Bu-2313 A.
D000192:Actinomycetales / Q000378:metabolism; D000617:Aminoglycosides; D000693:Anaerobiosis; D000818:Animals; D000900:Anti-Bacterial Agents / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007928:Lethal Dose 50; D051379:Mice
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C025512:BU-2313 A; C025513:BU-2313 B; C100307:streptolydigin