Effects of high dietary vitamin A on drug-metabolizing enzyme activities in guinea pig and rabbit.
The effect of high dietary Vitamin A on drug-metabolizing enzyme activities was studied in the guinea pig and rabbit. The guinea pigs and rabbits were given a high vitamin A test diet for six and seven weeks, respectively. The control groups received the diets containing normal amounts of vitamin A. The feeding of the high vitamin A diet increased the activities of aminopyrine demethylase and aniline hydroxylase in the guinea pig liver but not in the rabbit liver. The 7-ethoxycoumarin deethylase activities were increased in the rabbit liver but not in the guinea pig liver. The aminopyrine demethylase and aniline hydroxylase activities were lowered in both lung and intestine of rabbit. The benzpyrene hydroxylase activities were lowered only in rabbit lung. In general, these results suggest that the effect of a high vitamin A in diet on drug-metabolizing enzymes depends on the animal species, type of tissue, and substrate used.
D000818:Animals; D001579:Benzopyrene Hydroxylase / Q000037:antagonists & inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004224:Diterpenes; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D008861:Microsomes / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D011817:Rabbits; D000084562:Retinyl Esters; D014801:Vitamin A / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*
D004224:Diterpenes; D011506:Proteins; D000084562:Retinyl Esters; D014801:Vitamin A; C009166:retinol acetate; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D001579:Benzopyrene Hydroxylase