Effects of pulmonary x-irradiation and pulmonary tumor burden on hypoxia tolerance of mice.
Hypoxia tolerance was measured in female C3H mice which had been given single thoracic X-ray exposures or which were bearing pulmonary tumors. Thoracic X-ray exposures ranging from 500-1500 rad had no significant effect on hypoxic tolerance for up to 56 d following irradiation. The presence of pulmonary tumors from the Dunn osteosarcoma had no significant effect on hypoxic tolerance until a tumor burden of about 200 mm3 was reached. It is concluded that neither a pulmonary radiation history nor moderate lung tumor burdens militate against using reduced oxygen environments in radiotherapeutic regimens to treat pulmonary tumors.
D000818:Animals; D005260:Female; D000860:Hypoxia / Q000503:physiopathology*; D008175:Lung Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy*; D051379:Mice; D009374:Neoplasms, Experimental / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy; D012516:Osteosarcoma / Q000532:radiotherapy; D011879:Radiotherapy Dosage