Clefts in quintuplets--a case report.
A report of clefting in three siblings of quintuplets, following treatment with Pergonal, is presented. It is suggested that the varying degrees of the abnormality may be related to cramped intra-uterine conditons or differing pressures at a critical developmental stage. To our knowledge, no previous reports of congential abnormalities associated with Pergonal therapy exist, and we feel that the causal relationship should be explored using a suitable animal model.
D000539:Alveolar Process / Q000002:abnormalities*; D006063:Chorionic Gonadotropin / Q000009:adverse effects; D002971:Cleft Lip / Q000209:etiology*; D002972:Cleft Palate / Q000209:etiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011811:Quintuplets
D006063:Chorionic Gonadotropin