Combination of minocycline and rifampicin against methicillin- and gentamicin-resistant Staphylococcus aureus.
Methicillin- and gentamicin-resistant Staphylococcus aureus may remain sensitive to minocycline and to rifampicin. A study of growth curves has shown that at inhibitory concentrations (0.4 mug/ml), minocycline prevents the development of mutants resistant to rifampicin.
D005839:Gentamicins / Q000494:pharmacology*; D008712:Methicillin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000494:pharmacology*; D010403:Penicillin Resistance; D012293:Rifampin / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013754:Tetracyclines / Q000494:pharmacology*
D005839:Gentamicins; D013754:Tetracyclines; D008911:Minocycline; D008712:Methicillin; D012293:Rifampin