[An experimental model for adjusting the rhythm of irradiation to the kinetics of the tissues to be irradiated].
To obtain better results with radiotherapy it is necessary to take into account the tissue kinetics. Synchronized cell cultures in vitro show that the radiation-induced mitotic delay and the survival curves are cell phase-dependent. It is necessary to follow the evolution of the different cell populations in the irradiated volume. It can be done using a distribution factor (fD), that may be defined as the quotient between the number of S-phase cells and the number of cells in the remaining phases at a given moment.
D002453:Cell Cycle; D002470:Cell Survival / Q000528:radiation effects; D006367:HeLa Cells / Q000528:radiation effects; D006801:Humans; D008938:Mitosis / Q000528:radiation effects; D008954:Models, Biological; D011827:Radiation; D013997:Time Factors
Estudio de un modelo experimental para adecuar el ritmo de irradiación a la cinética de los tejidos a irradiar.