Increased kallikrein excretion in spontaneously hypertensive rats and its inhibition by 6-hydroxydopamine.
Urinary kallikrein excretion was studied in young, stroke-prone, spontaneously hypertensive rats (spSHR). Seven-week-old spSHR were found to excrete more kallikrein into the urine than normotensive Wistar Kyoto control rats (WKR). "Chemical sympathectomy", induced by 6-hydroxydopamine (6-OHDA) immediately after birth, resulted in normotensive blood-pressure levels and in a reduction of kallikrein in spSHR. In normotensive WKR, blood pressure and urinary kallikrein excretion were only slightly diminished by 6-OHDA. The results suggest a relationship between sympathetic activity and kallikrein excretion, being especially pronounced in spSHR, which have an elevated sympathetic activity.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D006892:Hydroxydopamines / Q000494:pharmacology*; D006973:Hypertension / Q000378:metabolism*; D007610:Kallikreins / Q000378:metabolism* / Q000652:urine; D008297:Male; D051381:Rats
D006892:Hydroxydopamines; D007610:Kallikreins