An effect of sulfur nutrition on the metabolism of salicylamide.
The effect of supplementing diets containing 15% casein with inorganic sulfate and/or the sulfur-containing amino acids on the metabolism of salicylamide was determined. The glucuronide-salicylamide:sulfate-salicylamide (GS:SS) ratio in the urine of rats fed the diets containing 15% of casein without inorganic sulfate or sulfur containing amino acid supplementation approached unity. Addition of either 0.02% of inorganic sulfate or 0.625% of methionine reduced this ratio to approximately 0.3%. Addition of 0.325% of methionine or sufficient cysteine to be equimolar with 0.625% methionine did not lower the GS:SS ratio significantly. Therefore, it appears that not only the level but the source of sulfur may be important in the detoxication of drugs.
D000818:Animals; D003545:Cysteine / Q000494:pharmacology; D004032:Diet; D005260:Female; D005965:Glucuronates / Q000378:metabolism; D008715:Methionine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012457:Salicylamides / Q000378:metabolism*; D013431:Sulfates / Q000008:administration & dosage / Q000378:metabolism; D013455:Sulfur / Q000008:administration & dosage / Q000494:pharmacology*
D005965:Glucuronates; D012457:Salicylamides; D013431:Sulfates; D013455:Sulfur; D008715:Methionine; C031060:salicylamide; D003545:Cysteine