[Mechanisms of action and clinical importance of C3-nephritic-factor (author's transl)].
The C3-nephritic-factor is an autoantibody specific against C3-convertases. This IgG-immunoglobulin is particularly found in patients suffering from membranoproliferative glomerulonephritis and causes a complement-activation under elimination of physiological regulator mechanisms. The clinical importance of this factor is discussed.
D003178:Complement C3 Nephritic Factor / Q000276:immunology*; D050577:Complement C3-C5 Convertases / Q000276:immunology; D003169:Complement Inactivator Proteins / Q000276:immunology*; D003170:Complement Pathway, Alternative; D003404:Creatinine / Q000097:blood; D005921:Glomerulonephritis / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D011188:Potassium / Q000097:blood; D011379:Prognosis
D003178:Complement C3 Nephritic Factor; D003169:Complement Inactivator Proteins; D007074:Immunoglobulin G; D003404:Creatinine; D050577:Complement C3-C5 Convertases; D011188:Potassium
Wirkungsmechanismus und klinische Bedeutung des C3-Nephritis-Faktors.