[CNS prophylaxis in acute lymphoblastic leukemia (author's transl)].
Results of CNS prophylaxis of 43 LLA children are studied. Prognostic characteristics of the group, follow-up time, and controls made are reported. Prophylaxis was made with intrathecal methotrexate associated to craneal (24 patients) or craneospinal irradiation. There was a 13% of meningosis between three and 27 months of the first complete remission. There were no differences of effectiveness between the two methods of treatment. The side effects were mild. Fifty five percent of patients showed fever, and vomits after intrathecal methotrexate injections, and 16% somnolence postradiotherapy syndrome. There were two more severe complications, one sepsis and one necrotizing leukoencephalopathy.
D000284:Administration, Oral; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001927:Brain Diseases / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D003037:Cobalt Radioisotopes / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D007278:Injections, Spinal; D007945:Leukemia, Lymphoid / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage*; D011878:Radiotherapy / Q000009:adverse effects; D013118:Spinal Cord Diseases / Q000517:prevention & control*
D000970:Antineoplastic Agents; D003037:Cobalt Radioisotopes; D008727:Methotrexate
Profilaxis de sistema nervioso central en leucemia linfoblástica aguda.