Quantitative alterations in the nucleolar and nucleoplasmic ribosomal ribonucleic acids in regenerating rat liver.
A quantitative analysis of the nuclear pre-rRNA (precursor to rRNA) and rRNA in normal and 12h-regenerating rat liver was carried out, and the absolute amounts of the identified pre-rRNA and rRNA species in the nucleolus and nucleoplasm were determined. Characteristic changes in the pre-rRNA and rRNA pool sizes in regenerating liver are found which reveal alternations in both pre-rRNA processing and nucleocytoplasmic transition of ribosomes.
D000818:Animals; D002466:Cell Nucleolus / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000166:cytology / Q000378:metabolism; D008115:Liver Regeneration; D008297:Male; D009694:Nucleic Acid Precursors / Q000378:metabolism*; D012322:RNA Precursors; D012335:RNA, Ribosomal / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D009694:Nucleic Acid Precursors; D012322:RNA Precursors; D012335:RNA, Ribosomal