Plasma catecholamines in long-term diabetes.
To investigate a possible defect in sympathetic innervation of the blood vessels in diabetics, 18 normals, 13 normotensive juvenile diabetics without complications and 13 normotensive juvenile diabetics with complications were first treated with an increasing infusion of norepinephrine (NE) and subsequently given a two minutes' exercise with a 150 Watt load. Plasma catecholamines were measured under both conditions. In the infusion experiments diabetics were found to have higher NE levels than normals. In normals NE fells to starting levels 5 min. after completion of the work load. In diabetics this fall-back rate was slower. The reduction in the fall-back rate was correlated with the duration of the diabetes.
D000328:Adult; D002395:Catecholamines / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006973:Hypertension / Q000097:blood*; D009638:Norepinephrine / Q000097:blood*; D012016:Reference Values
D002395:Catecholamines; D009638:Norepinephrine