Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: XI. A theoretical interpretation of the sequential methylation of yeast phenylalanine tRNA.
Theoretical studies on the mechanisms of methylation of tRNA was reported in a previous paper dealing with the induction of genic activity of proposed "embryonic" tRNA methylases. The mechanism described only the first methylation of a tRNA that had a known structure, namely yeast phenylalanine tRNA. In this paper, a complete scheme of methylation for the molecule is reported in detail using molecular model building. The mechanism uses only one specific uridine residue with which S-adenosyl-L-methionine complexes for all required methylation sites.
D008745:Methylation; D008958:Models, Molecular; D012346:RNA, Transfer, Amino Acyl / Q000378:metabolism*; D015003:Yeasts / Q000378:metabolism
D012346:RNA, Transfer, Amino Acyl