An in vivo model for studying adherence of intestinal pathogens.
A new method for preparing an isolated colonic loop in a living rabbit is described. The loop with its intact neurovascular supply can be used as as a "living test tube" to study the adherence of microorganisms to intestinal mucosa. Moreover, the clear colonic mucus produced by the loop can be used to study its physiochemical nature and protecting properties in health and disease.
D000268:Adhesiveness; D000818:Animals; D001419:Bacteria / Q000472:pathogenicity; D018407:Bacterial Physiological Phenomena; D003106:Colon / Q000601:surgery; D007413:Intestinal Mucosa / Q000382:microbiology*; D008722:Methods; D011817:Rabbits