In vitro comparison of clindamycin and pirlimycin (U-57930E) activity against Staphylococcus aureus.
The activities of clindamycin and its derivative, pirlimycin (U-57930E), were compared against 100 strains of Staphylococcus aureus, using a microtiter broth dilution technique. Minimal inhibitory concentrations demonstrated that pirlimycin was comparable to clindamycin but offered no increase in activity against either methicillin-susceptible or methicillin-resistant S. aureus.
D002981:Clindamycin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008712:Methicillin / Q000494:pharmacology; D010403:Penicillin Resistance; D013211:Staphylococcus aureus / Q000187:drug effects*
D002981:Clindamycin; C034093:pirlimycin; D008712:Methicillin