Dermal necrosis following coumarin: is it immunologically induced?
Two patients with dermal necrosis due to anticoagulation therapy with warfarin are reported. Both patients demonstrated some disturbance in immunological function. It appears possible that warfarin may act as a hapten in the induction of hypersensitivity to the drug. It is recommended that future cases should be studied to determine whether there is a defect in immunoregulation, and whether circulating immune complexes are responsible for the typical skin lesions.
D000368:Aged; D003176:Complement C3 / Q000032:analysis; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D008213:Lymphocyte Activation / Q000187:drug effects; D008875:Middle Aged; D009336:Necrosis; D010835:Phytohemagglutinins / Q000494:pharmacology; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced* / Q000276:immunology; D014859:Warfarin / Q000009:adverse effects*
D003176:Complement C3; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D010835:Phytohemagglutinins; D014859:Warfarin