[Changes in the kallikrein-kinin system in chronic hemodialysis patients].
The pre-kallikrein values, kallikrein inhibitors and protamine-splitting activity were determined in patients treated by means of chronic haemodialysis. Frequent use of dialysers leads to significant changes in the pre-kallikrein and kallikrein-inhibitor values. On the other hand the pre-kallikrein value remains unchanged after a single use of the capillary kidneys Hemoflow (Fresenius). A much smaller decrease in the kallikrein inhibitor value is observed than after frequent use of dialysers. In all the patients investigated the total protamine-splitting activity remained unchanged. Under these circumstances the inhibition capacity is probably sufficient to guarantee a control with respect to fibrinolysis, blood coagulation and the production of kinine.
D000293:Adolescent; D000328:Adult; D006801:Humans; D007610:Kallikreins / Q000037:antagonists & inhibitors / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000628:therapy; D007705:Kinins / Q000378:metabolism*; D008875:Middle Aged; D011288:Prekallikrein / Q000097:blood*; D011479:Protamines / Q000097:blood; D006435:Renal Dialysis / Q000009:adverse effects*
D007705:Kinins; D011479:Protamines; D011288:Prekallikrein; D007610:Kallikreins
Veränderungen im Kallikrein-Klinin-System bei chronischen Hämodialyse-Patienten.