A convenient animal model for testing bone substitute materials.
There is consijerable interest in developing substitute materials for bone to perform the functions of autogenous bone grafts. However, a persistent problem is finding a suitable animal model in which to test the biodegradable implants. This paper reviews the requirements of an ideal animal model for this purpose and discusses the shortcomings of existing procedures. A technique is described that uses the cranial vault of the rabbit and allows accurate radiologic and histologic assessment of implant resorption and ingrowth of new bone.
D000818:Animals; D001672:Biocompatible Materials; D005260:Female; D008297:Male; D010294:Parietal Bone / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000502:physiology* / Q000601:surgery; D011817:Rabbits / Q000033:anatomy & histology / Q000502:physiology* / Q000601:surgery; D011859:Radiography; D014207:Trephining; D014945:Wound Healing
D001672:Biocompatible Materials