Complement studies in children with treated coeliac disease after gluten challenge.
Changes of the complement components in the sera of 13 children with treated coeliac disease were studied after gluten challenge. The levels of C 1 and C3-activator (factor B) were significantly decreased at 4 h after the challenge, as were the levels of total complement (CH 50) and the components C 1, C 4 and C 1-inactivator at 8 h. After 24 h most values returned to normal but there was another significant decrease in serum C 4 after 24 h, and for CH 50, C 1, C 2 and C 4 after 48 h.
D002446:Celiac Disease / Q000178:diet therapy / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003172:Complement C1 / Q000032:analysis; D003174:Complement C1 Inactivator Proteins / Q000032:analysis; D050577:Complement C3-C5 Convertases / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis*; D005260:Female; D005983:Glutens; D006801:Humans; D008297:Male; D013997:Time Factors
D003172:Complement C1; D003174:Complement C1 Inactivator Proteins; D003181:Complement C4; D005983:Glutens; D003165:Complement System Proteins; D050577:Complement C3-C5 Convertases