Effect of dietary fat on X-ray-induced mammary cancer in Sprague-Dawley rats.
We studied the effect of dietary fat levels on the induction of mammary cancer by 350 rads total-body X-radiation given to noninbred albino Sprague-Dawley rats at 50 days of age. Compared to rats on a low-fat (LF) diet (5% lard), rats on a high-fat (HF) diet (20% lard) from 30 days of age had more tumors, with a higher multiplicity of carcinomas per rat. LF-fed groups exhibited a longer median tumor latency period thatn did HF-fed groups. A similar trend toward more tumors with an earlier time of death was seen in rats given single iv doses of 50 mg 1-methyl-1-nitrosourea/kg and fed an HF diet as compared to an LF diet.
D000818:Animals; D003043:Cocarcinogenesis; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000209:etiology*; D008770:Methylnitrosourea; D009378:Neoplasms, Multiple Primary / Q000209:etiology; D009381:Neoplasms, Radiation-Induced; D051381:Rats; D013997:Time Factors; D014965:X-Rays
D004041:Dietary Fats; D008770:Methylnitrosourea