Lymphocyte traffic through antigen-stimulated lymph nodes. I. Complement activation within lymph nodes initiates cell shutdown.
Complement activation within lymph nodes has been shown to alter lymphocyte traffic through the node. Challenge of cannulated sheep lymph nodes with either immune complexes or complement activators was found to initiate the phenomenon of cell shutdown associated with antigenic challenge of lymph nodes in primed animals.
D000818:Animals; D000917:Antibody Formation; D000936:Antigen-Antibody Complex / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D003167:Complement Activation; D050577:Complement C3-C5 Convertases / Q000032:analysis; D008198:Lymph Nodes / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012756:Sheep; D013604:T-Phages / Q000276:immunology; D013997:Time Factors; D014373:Tuberculin / Q000276:immunology
D000936:Antigen-Antibody Complex; D000956:Antigens, Viral; D011947:Receptors, Antigen, B-Cell; D014373:Tuberculin; D050577:Complement C3-C5 Convertases