Autoradiographic investigation of proliferative responses in rat incisor pulp after vincristine administration.
-0.7 mg/kg VCR was given to nine rats in three experimental groups. Twenty-three hours after VCR injection the animals were injected with 3H-thymidine. The animals were sacrificed 24, 48 and 72 h after the VCR injection, and by comparison with nine control animals similarly injected with sodium chloride solution and nucleotide, it was shown that VCR causes a delayed migration of pulp cells from the proliferative pool and a small but distinct inhibition of the incisal growth of the incisors. The growth inhibition corresponded to the normal growth over a 24-h period in non-VCR-injected animals.
D000818:Animals; D001345:Autoradiography; D002455:Cell Division / Q000187:drug effects; D003782:Dental Pulp / Q000166:cytology / Q000187:drug effects*; D005260:Female; D007180:Incisor / Q000166:cytology / Q000187:drug effects*; D009804:Odontoblasts / Q000187:drug effects; D009805:Odontogenesis / Q000187:drug effects; D051381:Rats; D013936:Thymidine; D013997:Time Factors; D014316:Tritium; D014750:Vincristine / Q000008:administration & dosage / Q000494:pharmacology*
D014316:Tritium; D014750:Vincristine; D013936:Thymidine