[Participation of the lungs in regulating the activity of the kallikrein-kinin system during immobilization stress].
Experiments on rats have shown that during immobilization stress, there takes place an intense activation of the kallikrein-kinin system (KKS). The control animals do not show arteriovenous difference in the KKS values. Study of the time course of immobilization stress has demonstrated changes in the KKS values attesting to the system activation seen only in venous blood in the early stages of immobilization. With time activation of the kinin system is also seen in arterial blood, and by 24 hours of immobilization the arteriovenous difference disappears. Thus the arteriovenous difference in the KKS values, which occurs during immobilization stress indicates the compensatory role of the lungs in the early stages of immobilization.
D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D006439:Hemodynamics; D007103:Immobilization; D007610:Kallikreins / Q000037:antagonists & inhibitors* / Q000097:blood*; D008168:Lung / Q000378:metabolism*; D008297:Male; D011288:Prekallikrein / Q000097:blood*; D011817:Rabbits; D051381:Rats; D012149:Restraint, Physical / Q000009:adverse effects; D013312:Stress, Physiological / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology
D011288:Prekallikrein; C019724:arginine esterase; D002265:Carboxylic Ester Hydrolases; D007610:Kallikreins
Uchastie legkikh v reguliatsii aktivnosti kallikrein-kininovoĭ sistemy pri immobilizatsionnom stresse.