Inhibition of zymosan-induced alternative complement pathway activation by concanavalin A.
Zymosan, a polysaccharide composed primarily of glucan and mannan residues, activates the complement system through the alternative complement pathway. We showed that zymosan-induced complement activation is inhibited by zymosan-bound lectins with carbohydrate specificities for mannosyl and glycosyl residues. Lectins unable to bind mannosyl or glucosyl residues did not inhibit zymosan-induced complement activation.
D003167:Complement Activation; D003172:Complement C1 / Q000378:metabolism; D003176:Complement C3 / Q000378:metabolism; D011415:Complement Factor B / Q000378:metabolism; D003170:Complement Pathway, Alternative; D003208:Concanavalin A / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D037102:Lectins / Q000494:pharmacology; D015054:Zymosan / Q000378:metabolism / Q000494:pharmacology*
D003172:Complement C1; D003176:Complement C3; D037102:Lectins; D003208:Concanavalin A; D015054:Zymosan; D011415:Complement Factor B