Effect of vibration on the activity of the plasma kallikrein-kinin system in the rat.
Rats were exposed to whole body vibration horizontally for four hours at 5 Hz frequency and 2 cm amplitude. Of the components of the plasma kallikrein-kinin system the free (spontaneous) and kaolin-activated kallikrein (prekallikrein) activities, the concentration of bradykinin, the bradykinin splitting total kininase activity, total kallikrein-inhibitor activity and the concentration of alpha 2-macroglobulin, a major plasma kallikrein inhibitor, were estimated. Results showed that in response to acute vibration plasma free kallikrein activity was increased significantly in association with a significant reduction of prekallikrein concentration. The concentrations of bradykinin and total kininase activity were significantly elevated, too. Neither total kallikrein-inhibitor activity nor the concentration of alpha 2-macroglobulin were changed indicating that the plasma kallikrein inhibitors did not play a role in the alterations of plasma free kallikrein and prekallikrein activities. During acute vibration the plasma kallikrein-kinin system was activated probably by the enhanced catecholamine secretion. We suggest that the biological importance of this phenomenon is in the defense against the impaired microcirculation caused by catecholamines.
D000818:Animals; D001920:Bradykinin / Q000097:blood; D002395:Catecholamines / Q000378:metabolism; D007610:Kallikreins / Q000097:blood*; D007705:Kinins / Q000097:blood*; D008297:Male; D011288:Prekallikrein / Q000097:blood; D011498:Protein Precursors / Q000097:blood; D051381:Rats; D013312:Stress, Physiological / Q000097:blood*; D014732:Vibration
D002395:Catecholamines; D007705:Kinins; D011498:Protein Precursors; C009858:bradykininogen; D011288:Prekallikrein; D007610:Kallikreins; D001920:Bradykinin