In situ drug delivery.
Drug delivery to tumours and the accessibility of tumour cells to drugs remains a problem of foremost importance and is affected by many factors. We will discuss models we have developed for drug delivery from tumour capillaries to tumour cells, and drug delivery from well perfused, well oxygenated tumour regions to less well perfused hypoxic regions in terms of computer simulation of drug delivery for the anticancer agent BCNU and the hypoxic cell radiosensitizer misonidazole.
D000818:Animals; D002196:Capillaries; D002330:Carmustine / Q000378:metabolism* / Q000627:therapeutic use; D006207:Half-Life; D008920:Misonidazole / Q000378:metabolism* / Q000627:therapeutic use; D008954:Models, Biological; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000188:drug therapy / Q000378:metabolism*; D009593:Nitroimidazoles / Q000378:metabolism*; D051381:Rats
D009593:Nitroimidazoles; D008920:Misonidazole; D002330:Carmustine