Neuromuscular diseases associated with benign monoclonal gammopathy. Study of CSF and serum proteins by isoelectric focusing.
In over 1200 cases examined by isoelectric focusing of CSF and serum proteins, 4 patients had benign monoclonal gammopathy. These patients were affected by amyotrophic lateral sclerosis of bulbar onset, sensitive neuropathy of Thevenard type, myasthenia gravis, and limb-girdle muscular dystrophy, respectively. The difficulty to relate the differences in the clinical features of these cases to a common physiopathological mechanism and the incidence of this finding (0.4% in 873 cases ranging from 21-60 years of age) do not seem to suggest any pathogenetic relationship between benign monoclonal gammopathy and the different neurological disorders encountered in these patients.
D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications; D009477:Hereditary Sensory and Autonomic Neuropathies / Q000150:complications; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D007074:Immunoglobulin G / Q000032:analysis* / Q000134:cerebrospinal fluid; D007525:Isoelectric Focusing; D008297:Male; D008875:Middle Aged; D009136:Muscular Dystrophies / Q000150:complications; D009157:Myasthenia Gravis / Q000150:complications; D009468:Neuromuscular Diseases / Q000150:complications*
D007074:Immunoglobulin G