Carcinogenicity test of acetoxime in MRC-Wistar rats.
Acetoxime was tested for carcinogenicity by chronic administration in the drinking water to male and female outbred MRC-Wistar rats. The dose of 1.0 g/liter was administered 5 days/week for 18 months (total dose, 6.2--7.0 g/rat). The test compound induced benign hepatocellular adenomas in 80% of the males but did not produce tumors in the females. This is the first report that oximes, which are fairly widely used in industry, are tumorigenic.
D000236:Adenoma / Q000139:chemically induced*; D000818:Animals; D001711:Biotransformation; D002273:Carcinogens; D004032:Diet; D005260:Female; D007928:Lethal Dose 50; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D009602:Nitrosamines / Q000633:toxicity; D010091:Oximes / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D002273:Carcinogens; D009602:Nitrosamines; D010091:Oximes; C035911:acetoxime