[HLA-antigens in the diagnosis and genetics of schizophrenia].
We found no convincing association of HLA-antigens and Schizophrenia with exception of a significant reduction of Aw19 in our study of 140 schizophrenic patients. The incidence of the haploids HLA-AI,B7, -A2,B18, -A2, Bw35, -A3,Bw35, -A1,Cw3, -A2,Cw3 has been significantly increased and the haploids HLA-A1,B8, -A2,B5, -A2,B7, -A2,Cw2, -B12,Cw4, -B27, Cw2 significantly decreased compared with normals. HLA-A1,B8, -A2,B5, -A2,B7, -A2,Cw2, -B12,Cw2 have shown an important imbalance of the alleles possibly induced by the lowered fertility and migration of schizophrenic patient.
D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*
D006680:HLA Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens
HLA-Antigene in Diagnostik und Genetik der Schizophrenie.