Spontaneous occurrence of atypical hyperplasia and adenocarcinoma of the uterus in androgen-sterilized SD rats.
In SD female rats sterilized by a single injection of testosterone propionate at 2 days after birth, the spontaneous occurrence of atypical hyperplasia and adenocarcinoma of the uterus was observed for a fairly long period (greater than 2 yr). Two atypical hyperplasias and 2 adenocarcinomas were detected in 25 androgen-sterilized rats (ASR) after 500 days of age; in contrast, in 111 normal control rats no abnormal uterine proliferation was detected during a 750-day observation period. These results indicate that a persistence of both hormone imbalances and dysfunctional uteri in ASR induces abnormal uterine proliferation at a late age.
D000230:Adenocarcinoma / Q000139:chemically induced*; D000818:Animals; D001835:Body Weight; D005260:Female; D006965:Hyperplasia; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013245:Sterilization, Reproductive; D013739:Testosterone; D014594:Uterine Neoplasms / Q000139:chemically induced*; D014599:Uterus / Q000187:drug effects / Q000473:pathology*
D013739:Testosterone