title: Immunogenicity of serum HLA antigens in allogeneic combinations.
abstract: Immunization of patients with chronic renal insufficiency with plasma from selected donors elicited lymphocytotoxic antibodies. Analysis of these antibodies with Fab2 blocking assays showed that they are directed to HLA-A,B and to Ia-like antigens. These results indicate that serum HLA antigens are immunogenic in allogeneic combinations.
mesh_terms: D000818:Animals; D000961:Antilymphocyte Serum / Q000276:immunology; D001667:Binding, Competitive; D001803:Blood Transfusion; D003601:Cytotoxicity Tests, Immunologic; D006680:HLA Antigens / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D007518:Isoantibodies / Q000096:biosynthesis*; D007676:Kidney Failure, Chronic / Q000276:immunology / Q000628:therapy; D010949:Plasma; D011817:Rabbits; D012397:Rosette Formation
chemical_list: D000961:Antilymphocyte Serum; D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II; D007140:Immunoglobulin Fab Fragments; D007518:Isoantibodies