Acetominophen toxicity. Report of two cases.
Both chronic low-dose use within accepted therapeutic limits and acute overdosage of acetominophen with as little as 7 Gm or 150 mg./kg. can result in irreversible centrilobular hepatic necrosis. Prompt and proper treatment with N-acetyl-cysteine in strict adherence to accepted protocol will prevent potentially fatal results. Clinicians who prescribe acetominophen must likewise be cognizant of other potential side effects, such as methemoglobinemia, hemolysis, and prothrombin suppression.
D000082:Acetaminophen / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000506:poisoning*; D000111:Acetylcysteine / Q000627:therapeutic use; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D013406:Suicide, Attempted
D000082:Acetaminophen; D000111:Acetylcysteine