Antibodies against double-stranded RNA in patients with rheumatoid arthritis, osteoarthrosis and Paget's disease of bone.
Using a liquid phase radioimmunoassay to detect antibodies to 3H-labelled double-stranded RNA the premise that rheumatoid arthritis and Paget's disease of the bone may be associated with a chronic virus disease was examined. About 33% of patients with rheumatoid arthritis had antibody levels above the normal range and 11% had antibody levels below the normal range of controls (blood bank donors). The low binding activities were attributed to the action of a nuclease that degraded the dsRNA. Some patients with Paget's disease of bone had higher binding activities than the normal range and similar binding activity was also found in patients with osteoarthrosis. The increase in antibodies to double-stranded RNA did not correlate with increasing age.
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis*; D001172:Arthritis, Rheumatoid / Q000209:etiology / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D010001:Osteitis Deformans / Q000209:etiology / Q000276:immunology*; D010003:Osteoarthritis / Q000276:immunology*; D012330:RNA, Double-Stranded / Q000276:immunology*; D012367:RNA, Viral / Q000276:immunology*; D014777:Virus Diseases
D000914:Antibodies, Viral; D012330:RNA, Double-Stranded; D012367:RNA, Viral