Postnatal effects of oral administration of ethylenethiourea to rats during late pregnancy.
Ethylenethiourea (ETU), a manufacturing, processing, and metabolic product of the ethylenebisdithiocarbamate fungicides, was evaluated for its effects on postnatal performance of rats. ETU was given to pregnant rats as a single oral dose of 1-50 mg/kg on day 17, 18, 19, or 20 of gestation. The number of stillborn rats was significantly increased at dose levels of 30 and 50 mg/kg. Treatment of dams with 50 mg/kg on day 20 of gestation caused reduction in the birth weight of the offspring. Progeny survival was impaired after maternal treatment with doses of 10 mg/kg and more. The high mortality was attributable to the development of hydrocephalus in the pups. At 6 months of age, 16 and 26% of the surviving offspring from dams treated with 10 or 20 mg/kg had hydrocephalus.
D000284:Administration, Oral; D000818:Animals; D005031:Ethylenethiourea / Q000633:toxicity*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005865:Gestational Age; D006128:Growth / Q000187:drug effects; D006849:Hydrocephalus / Q000139:chemically induced; D007093:Imidazoles / Q000633:toxicity*; D008297:Male; D011247:Pregnancy; D051381:Rats
D007093:Imidazoles; D005031:Ethylenethiourea