Effect of hydrocortisone on oxidative degradation of hexobarbital and ethylmorphine.
In experiments on albino rats of both sexes it has been established that hydrocortisone applied in a single dose of 50 mg/kg i.p. inhibits hexobarbital oxidase and ethylmorphine-N-demethylase and applied repeatedly in a dose of 10 mg/kg increases the activity of both enzymes. In castrated male rats the enzyme-inhibiting action of the single dose of hydrocortisone is much reduced, while its enzyme-inducing action on repeated application remains the same (the two effects are evaluated by the hexobarbital sleeping time).
D000818:Animals; D001711:Biotransformation; D002369:Castration; D004347:Drug Interactions; D005036:Ethylmorphine / Q000378:metabolism*; D005260:Female; D006591:Hexobarbital / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D009022:Morphine Derivatives / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013739:Testosterone / Q000494:pharmacology; D013997:Time Factors
D009022:Morphine Derivatives; D013739:Testosterone; D006591:Hexobarbital; D005036:Ethylmorphine; D006854:Hydrocortisone