Tardive dyskinesia with Tourette-like syndrome.
This is a single case study of a 22 year old Japanese-Canadian woman who developed schizophrenia, was treated with ECT and several successive neuroleptics and subsequently, three years later, developed a tardive dyskinesia syndrome in association with a behavioral change resembling Gilles de la Tourette disease. This combined syndrome lasted seven months. After neuroleptics were withdrawn, the syndrome diminished in severity and disappeared after four months. Since both tardive dyskinesia and Tourette's disease are thought to be caused by relative overactivity or supersensitivity of the dopamine system, their reversible appearance after long term dopamine receptor blockade by neuroleptics can be expected in susceptible individuals.
D000328:Adult; D003692:Delayed-Action Preparations; D004409:Dyskinesia, Drug-Induced / Q000150:complications* / Q000175:diagnosis; D005260:Female; D005476:Fluphenazine / Q000009:adverse effects; D006801:Humans; D011954:Receptors, Dopamine / Q000187:drug effects; D005879:Tourette Syndrome / Q000139:chemically induced / Q000150:complications* / Q000523:psychology
D003692:Delayed-Action Preparations; D011954:Receptors, Dopamine; D005476:Fluphenazine