Serum theophylline levels in adult asthmatics: comparison of oral sustained-release and microcrystalline preparations.
Serial serum theophylline levels were measured in 20 inpatient asthmatics given tablets of either microcrystalline or sustained-release theophylline. The sustained-release preparation gave serum levels which were more consistently within the therapeutic range with a significantly higher trough concentration. No increase in adverse effects was encountered.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000097:blood; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013806:Theophylline / Q000008:administration & dosage* / Q000097:blood
D001993:Bronchodilator Agents; D003692:Delayed-Action Preparations; D013806:Theophylline