Effects of some cholephilic agents on hepatic mitochondrial respiration and biliary excretion.
Indocyanine green, rose bengal and bromsulphthalein have low biliary excretory rates. They depress bile flow and are strong inhibitors of hepatic mitochondrial respiration, whereas the glutathione conjugate of bromsulphthalein, iodoxamic acid and amaranth have high biliary excretory rates, enhance bile formation and do not inhibit hepatic mitochondrial respiration.
D000818:Animals; D001646:Bile / Q000187:drug effects*; D066298:In Vitro Techniques; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats