Different role of biotransformation in the elimination of some important pharmaceuticals and industrial xenobiotics.
Unlike lipophilic pharmaceuticals, many lipophilic industrial xenobiotics may be excreted unchanged due to their volatility. Consequently, enzyme induction of inhibition may thus affect only the rate of metabolism of the lipophilic drugs, whereas in case of volatile xenobiotics it is both the rate and the extent (metabolized portion) of their biotransformation which are influenced by these processes. The influence of these metabolic changes on the rate of elimination is more pronounced in lipophilic pharmaceuticals than in volatile xenobiotics whose alternative elimination via lungs compensates for the metabolic rate differences.
D000818:Animals; D001711:Biotransformation; D055598:Chemical Phenomena; D002621:Chemistry; D004347:Drug Interactions; D004790:Enzyme Induction; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010969:Plastics / Q000378:metabolism; D012997:Solvents / Q000378:metabolism*
D004364:Pharmaceutical Preparations; D010969:Plastics; D012997:Solvents