Transient Gilles de la Tourette syndrome after chronic neuroleptic withdrawal.
A retarded 16-year-old male developed symptoms consistent with Gilles de la Tourette syndrome within one month of withdrawal from chronic neuroleptic treatment. The symptoms began to subside after six months and he was symptom-free after seven months. This suggests that symptoms of Gilles de la Tourette syndrome which appear after withdrawal of chronic neuroleptic therapy may be due to transient hypersensitivity of dopamine receptor sites.
D000293:Adolescent; D002746:Chlorpromazine / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000150:complications*; D006220:Haloperidol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011954:Receptors, Dopamine / Q000009:adverse effects; D013375:Substance Withdrawal Syndrome; D005879:Tourette Syndrome / Q000209:etiology*
D011954:Receptors, Dopamine; D006220:Haloperidol; D002746:Chlorpromazine