Surface antigens on Marek's disease lymphoblastoid tumor cell lines.
A total of 32 Marek's disease virus (MDV)-induced cell lines, 1 avian leukosis virus-induced cell line, and 1 reticuloendotheliosis virus (REV)-induced lymphoblastoid cell line were investigated for the presence of Fc receptors, surface IgM, and Ia-like antigen. Surface IgM and Fc receptors could not be demonstrated on any of the cell lines. Ia-like antigen was detected on all MDV-induced cell lines and on the 1 REV-induced cell line. Ia-like antigen was unrelated to other antigens reported to be present on Marek's disease tumor cells. It was also unimportant as a target antigen for MDV-related, allogeneic cell-mediated cytotoxicity. The densities of the cells of 5 MDV-induced cell lines were established on continuous Percoll gradients. Most cells had densities between 1.05 and 1.06 g/ml.
D000818:Animals; D000911:Antibodies, Monoclonal; D000920:Antibody-Dependent Cell Cytotoxicity; D000954:Antigens, Surface / Q000032:analysis*; D002460:Cell Line; D002469:Cell Separation; D002645:Chickens; D000949:Histocompatibility Antigens Class II / Q000032:analysis / Q000276:immunology; D007075:Immunoglobulin M / Q000032:analysis; D008214:Lymphocytes / Q000276:immunology* / Q000648:ultrastructure; D008380:Marek Disease / Q000276:immunology*; D011961:Receptors, Fc / Q000032:analysis
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D000949:Histocompatibility Antigens Class II; D007075:Immunoglobulin M; D011961:Receptors, Fc