title: Multiple forms of phenolsulphotransferase in human tissues: selective inhibition by dichloronitrophenol.
abstract: Evidence is presented for two functional forms of phenolsulphotransferase in human tissues: (1) activity ratios, using dopamine and phenol as substrates, varied 30-fold between different tissues, whereas the dopamine to tyramine activity ratio was relatively constant; (2) incubation at 37 degrees caused a selective decrease in activity towards dopamine compared with phenol; and (3) phenol sulphoconjugation was selectively inhibited by dichloronitrophenol and pentachlorophenol compared with that of dopamine and tyramine. The two forms, which have been designated M (monoamines) and P (phenol), were both present in platelets, jejunum, adrenal and brain.
mesh_terms: D015239:Arylsulfotransferase; D001792:Blood Platelets / Q000201:enzymology; D001921:Brain / Q000201:enzymology; D004298:Dopamine; D005260:Female; D006358:Hot Temperature; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009596:Nitrophenols / Q000494:pharmacology*; D019800:Phenol; D010636:Phenols; D013379:Substrate Specificity; D013466:Sulfurtransferases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D009596:Nitrophenols; D010636:Phenols; D019800:Phenol; D013466:Sulfurtransferases; D015239:Arylsulfotransferase; D004298:Dopamine