Childhood acute lymphoblastic leukemia associated with an unusual 8;14 translocation.
An 8;14 chromosome translocation with the break points t(8;14(q11;q32) is described in bone marrow cells of a patient with null cell terminal deoxynucleotidyl transferase (TdT)-positive acute lymphoblastic leukemia. The patient, who is dysmorphic and mentally retarded, ha a normal 46,XY constitutional chromosome karyotype. A review of the more usual cytogenetic findings in this type of leukemia and a comparison of B-cell lymphoproliferative cytogenetic associations are presented.
D000293:Adolescent; D001853:Bone Marrow / Q000503:physiopathology; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002901:Chromosomes, Human, 13-15; D002906:Chromosomes, Human, 6-12 and X; D004253:DNA Nucleotidylexotransferase / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic
D004253:DNA Nucleotidylexotransferase