Association of specific chromosome abnormalities with type of acute leukemia and with patient age.
Complete data regarding age, sex, karyotype, and French-American-British Cooperative Group classification were available for 239 unselected patients with acute nonlymphocytic leukemia. Of these, 128 were classified as having acute myeloblastic leukemia (M1 or M2); within the acute myeloblastic leukemia group, 83 (65%) of the patients were chromosomally abnormal. Except for 16 patients with a t(8;21), the percentage of patients with an abnormal karyotype increased with age, particularly above the age of 50 years. Besides the patients with t(8;21), there were 29 patients with loss of part or all of chromosomes 5 and/or 7, 11 patients with +8, and 27 patients with other abnormalities. Of 70 patients with acute myelomonocytic leukemia (M4), on the other hand, 28 (40%) were chromosomally abnormal, only three had loss of chromosomes 5 or 7, one was -7, +8, and our were +8, whereas 20 had other abnormalities. This difference may reflect different etiological factors in these two types of leukemia.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000145:classification*; D025063:Chromosome Disorders; D002904:Chromosomes, Human, 21-22 and Y; D002905:Chromosomes, Human, 4-5; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D007223:Infant; D007621:Karyotyping; D007938:Leukemia / Q000145:classification* / Q000648:ultrastructure; D015470:Leukemia, Myeloid, Acute / Q000145:classification; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
D007140:Immunoglobulin Fab Fragments