The anti-implantation action of tamoxifen in mice.
The process of implantation of the blastocyst in utero in the mouse is normally triggered by oestradiol-17 beta. It can, however, be prevented by the drug tamoxifen whose actions in other species are classified as anti-oestrogenic, but which the mouse is held to be a weak oestrogen. Results are presented which support the claim that the anti-implantation action of tamoxifen is dose dependent, oestrogenicity dominating at high doses and anti-oestrogenicity being of major importance at lower doses.
D000818:Animals; D001755:Blastocyst / Q000187:drug effects; D004347:Drug Interactions; D010064:Embryo Implantation / Q000187:drug effects*; D004622:Embryo, Mammalian / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology; D005187:Fallopian Tubes / Q000187:drug effects; D005260:Female; D051379:Mice; D011247:Pregnancy; D013629:Tamoxifen / Q000633:toxicity*; D014327:Trophoblasts / Q000187:drug effects
D013629:Tamoxifen; D004958:Estradiol