Coincidence of cytogenetic markers in four murine cell lines.
Foreign body tumorigenesis was induced by the subcutaneous implantation of a plastic or glass cylinder in BALB/c mice; the inoculation of human neoplastic cells significantly increased the incidence of these anaplastic sarcomas. Of 15 tumors studied, four presented the same markers: one induced with and three without human neoplastic cell inoculation within the foreign body. The markers observed were double minutes (DM), a long acrocentric marker (MLA), and a metacentric marker (MM). The DM are a number of small often tiny chromosomal structures appearing in pairs together with chromosomes of ordinary size. MLA is a long acrocentric derived from a translocation in tandem between chromosomes #1 and #16. MM is due to centric fusion of two chromosomes #10. Numerical anomalies consisted of gains of the same chromosomes types. It is postulated that these coincident findings are related to the foreign-body tumorigenesis.
D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations; D005819:Genetic Markers; D051379:Mice; D008807:Mice, Inbred BALB C; D010969:Plastics; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000235:genetics*
D005819:Genetic Markers; D010969:Plastics