The effect of prostaglandins (PGE2 and PGF2 alpha) on food intake in rats.
Intracerebroventricular administration of PGF2 alpha and PGE2 suppressed food intake in several feeding models. PGF2 alpha (20 micrograms) and PGE2 (20 micrograms to 1 micrograms) suppressed food intake following a 24 hour starvation. PGF2 alpha (20 micrograms) and PGE2 (20 micrograms) suppressed food intake following central administration of the feeding induces norepinephrine and muscimol. These prostaglandins also suppressed stress induced eating using the tail pinch model at doses of 20 micrograms, 10 micrograms and 5 micrograms with eating returning to control levels at the 1 micrograms dose. D-Ala Methionine Enkephalin failed to alter the suppressive effects of PGF2 alpha and PGE2 at a dose of 1 microgram but successfully reversed the effect of PGF2 alpha at a 10 micrograms dose while still having no effect on PGE2 suppression of feeding.
D000818:Animals; D015237:Dinoprost; D015232:Dinoprostone; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D009118:Muscimol / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation / Q000523:psychology
D011458:Prostaglandins E; D011460:Prostaglandins F; D009118:Muscimol; D015237:Dinoprost; D015232:Dinoprostone; D009638:Norepinephrine