Specific cellular stimulation in the primary immune response: experimental test of a quantized model.
Dose-response and dose-suppression curves have been measured for the primary immune response in mice, in vivo and in vitro, by using size-fractionated linear polymers of acrylamide substituted with hapten. The results are in general agreement with a simple theory based on the premise that the specific primary immunological response is quantized at some fundamental and limiting step, requiring a minimum number of linked antigen receptors for response.
D000180:Acrylic Resins / Q000276:immunology; D000818:Animals; D000917:Antibody Formation; D000955:Antigens, T-Independent; D004136:Dinitrobenzenes / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D006241:Haptens; D007700:Kinetics; D051379:Mice; D008954:Models, Biological; D011946:Receptors, Antigen / Q000502:physiology*; D000099166:Polyacrylamides
D000180:Acrylic Resins; D000955:Antigens, T-Independent; D004136:Dinitrobenzenes; D006241:Haptens; D011946:Receptors, Antigen; D000099166:Polyacrylamides