[Effect of prostaglandins E1 and E2 on thrombocyte form and aggregation].
Preliminary incubation of platelets with prostaglandin E1(PGE1) led to the inhibition of changes in platelet shape caused by ADP. PGE1 also blocked changes in the content of membrane-bound calcium in platelets, which are known to take place under ADP-induced changes in platelet shape. Stable changes in platelet shape were observed on incubation in the medium with pH 9.0. Addition of PGE1 in this case stimulated the normalization of the cell shape. PGE2 alone produced changes in the platelet shape and decreased the content of membrane-bound calcium. Simultaneous addition of PGE2 and ADP prevented the recovery of the native shape of the cells.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000527:Alprostadil; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects* / Q000648:ultrastructure; D002751:Chlortetracycline / Q000494:pharmacology; D015232:Dinoprostone; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D010974:Platelet Aggregation / Q000187:drug effects*; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats
D011458:Prostaglandins E; D000244:Adenosine Diphosphate; D000527:Alprostadil; D015232:Dinoprostone; D002751:Chlortetracycline
Vliianie prostaglandinov E1 i E2 na formu i agregatsiiu trombotsitov.