Acute and cutaneous toxicity of beta-chlorovinyl ketones and aldehydes in rodents.
The acute toxicity (LD50, intraperitoneal in the mouse) of beta-chlorovinyl ketones and aldehydes used as intermediates for organic syntheses was determined and their action on the skin of rodents investigated. Ketones of the type Cl-CH-CH-COR prove to be relatively toxic and display a markedly necrotic action after percutaneous absorption. In comparison with this the isomeric aldehydes Cl-CR-CH-CHO have a lower acute and less markedly cutaneous toxicity. As therapeutic counter action after skin contamination by beta-chlorovinyl carbonyl compounds the immediate treatment with an aqueous ethanolic solution of hexamethylenetetramine is recommendable.
D000287:Administration, Topical; D000447:Aldehydes / Q000633:toxicity; D000818:Animals; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D007659:Ketones / Q000633:toxicity*; D007928:Lethal Dose 50; D051381:Rats; D012867:Skin / Q000473:pathology; D013997:Time Factors; D014753:Vinyl Compounds / Q000633:toxicity*
D000447:Aldehydes; D007659:Ketones; D014753:Vinyl Compounds