Heterozygosity at Gm loci associated with humoral immunity to osteosarcoma.
Serum samples from 50 Caucasian patients with osteosarcoma were tested for the presence of antibodies to osteosarcoma-associated antigens (OSAA) and typed for nine Gm markers. A highly significant association was found between Gm 3;5,13,14 and unresponsiveness to OSAA, and between 1,3,17;5,13,14,21 and responsiveness to OSAA. These results suggest the existence of complementary immune response genes which in the heterozygous condition permit a response to OSAA.
D000917:Antibody Formation; D000951:Antigens, Neoplasm / Q000276:immunology; D002874:Chromosome Mapping; D006579:Heterozygote; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics* / Q000276:immunology; D007074:Immunoglobulin G / Q000235:genetics*; D012516:Osteosarcoma / Q000235:genetics* / Q000276:immunology; D010641:Phenotype
D000951:Antigens, Neoplasm; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G