Linkage of GLO with HLA in a sample of the Spanish population.
GLO allele frequencies are studied in 100 unrelated normal Spaniards. GLO-S shows a frequency similar to that found in Caucasoids. Weak linkage disequilibria between some HLA-B and some HLA-DR antigens are described. DR3 and DR4 are GLO-F associated both in normal and insulin dependent diabetic Spaniards. GLO/HLA-DR loci distance is about 6cM according to our family studies; females show a higher GLO/HLA-DR recombination rate than males in our sample. NO GLO heterozygous excess or "nul" alleles are found.
D000328:Adult; D000483:Alleles; D002648:Child; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D007791:Lactoylglutathione Lyase / Q000235:genetics*; D008190:Lyases / Q000235:genetics*; D008297:Male; D011995:Recombination, Genetic; D012737:Sex Factors; D013030:Spain
D006680:HLA Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D008190:Lyases; D007791:Lactoylglutathione Lyase