title: [Intensive treatment results on 426 children with acute lymphoblastic leukemia. Polish Group for the Treatment of Leukemia and Other Neoplastic Diseases of the Hematopoietic System in Children].
abstract: The results of intensive treatment of 426 children with acute lymphoblastic leukaemia were analysed and compared with the results in 113 patients treated by sparing method. A considerable prolongation of the duration of the first remission and survival was observed in the group treated intensively. Thus 44.8% of children in that group had a chance of 5 years of survival, as compared with 1.2% of children treated by the sparing methods. A difference was demonstrated in the distribution of the duration of the first remission and the survival time depending on the initial white blood cell count with worse results in patients with very high leucocytosis. Brain involvement developed in 13.6% of cases. The proportion of children dying of infections despite continuing remission was 4.6%. In 72 children treatment of leukaemia was terminated.
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D002648:Child; D003422:Critical Care; D004359:Drug Therapy, Combination; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D011044:Poland; D012306:Risk
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Wyniki intensywnego leczenia 426 dzieci z ostra białaczka limfoblastyczna. Polska grupa d/s leczenia białaczki i innych chorób nowotworowych układu krwiotwórczego u dzieci.