Some epistatic two-locus models of disease. II. The confounding of linkage and association.
This paper continues to examine the model discussed in the preceding paper. Specifically, it will be shown how a linkage analysis performed in the presence of a disease-marker association can give rise to erroneous and misleading results.
D000483:Alleles; D002874:Chromosome Mapping; D004843:Epistasis, Genetic; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008126:Lod Score; D008957:Models, Genetic; D012306:Risk
D005819:Genetic Markers; D006680:HLA Antigens