title: Influence of liver enzyme induction caused by diphenylhydantoin and diazepam on bone mass of rats.
abstract: 25 albino rats of Wistar strain were used for the study. They were divided into three groups. Animals of the first group (n = 10) were treated with Diphenylhydantoin in a daily dose of 70 mg/kg for three months. Animals of the second group (n = 10) were treated with Diazepam in a daily dose of 10 mg/kg for 3 months. Animals of the third group (n = 5) were treated with 5% acacia oil for the same period of time. Food and water consumption together with motor activity were measured. As indices of enzyme induction, D-Glucaric acid and liver weight were determined. Also the following bone indices were determined: femur Ca/femur weight, femur Ca/body weight, humerus Ca/humerus weight, humerus Ca/body weight, femur specific weight, humerus specific weight. Statistically significant alterations of bone mass were found.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001846:Bone Development; D001842:Bone and Bones / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D003975:Diazepam / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects*; D005937:Glucaric Acid / Q000652:urine; D008099:Liver / Q000201:enzymology*; D009929:Organ Size / Q000187:drug effects; D010672:Phenytoin / Q000494:pharmacology*; D051381:Rats
chemical_list: D010672:Phenytoin; D003975:Diazepam; D005937:Glucaric Acid; D002118:Calcium