Sensitivity of serum glutamic oxaloacetic transaminase and bile acid levels for the detection of experimental liver injury in rats.
Serum glutamic oxaloacetic transaminase (SGOT) and serum bile acid levels (SBA) were determined in serial blood samples of rats treated with two different hepatotoxins (carbon tetrachloride or D-galactosamine). SGOT was found to be more sensitive than SBA in detecting experimental liver injury.
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood*; D001647:Bile Acids and Salts / Q000097:blood*; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury; D004796:Clinical Enzyme Tests; D004195:Disease Models, Animal; D005688:Galactosamine / Q000633:toxicity; D008107:Liver Diseases / Q000175:diagnosis*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001647:Bile Acids and Salts; D005688:Galactosamine; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases