Chromosomal mapping of human creatine kinase (brain type) using human-rodent somatic cell hybrids.
Concordant segregation of human brain-type creatine kinase, CK(BB), expression with nucleoside phosphorylase (NP) expression and the presence of chromosome 14 was observed in 53 independently derived cell hybrids between CK(BB)-positive human cells and CK(BB)-negative rodent cells. Further analysis of 26 subclones of two CK(BB)-positive human-mouse cell hybrids confirmed the positive correlation of CK(BB) expression with NP expression. The results suggest that the gene coding for human CK(BB) can be assigned to chromosome 14.
D000818:Animals; D001921:Brain / Q000201:enzymology; D002874:Chromosome Mapping; D002901:Chromosomes, Human, 13-15; D003402:Creatine Kinase / Q000235:genetics*; D006224:Cricetinae; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells / Q000201:enzymology; D007527:Isoenzymes / Q000235:genetics*; D051379:Mice
D005819:Genetic Markers; D007527:Isoenzymes; D003402:Creatine Kinase