title: Inactivation of human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase with active site-directed 17 beta-propynyl-substituted progestin analogs.
mesh_terms: D015067:17-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors*; D015089:20-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors*; D000735:Androstenedione / Q000031:analogs & derivatives* / Q000494:pharmacology; D000737:Androstenols / Q000494:pharmacology*; D001665:Binding Sites; D004960:Estradiol Dehydrogenases / Q000037:antagonists & inhibitors*; D005260:Female; D006801:Humans; D007700:Kinetics; D010920:Placenta / Q000201:enzymology*; D011247:Pregnancy; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D000737:Androstenols; D000735:Androstenedione; C028438:17 beta-((1R)-1-hydroxy-2-propynyl)androst-4-en-3-one; C028439:17 beta-(1-oxo-2-propynyl)androst-4-en-3-one; D015067:17-Hydroxysteroid Dehydrogenases; D015089:20-Hydroxysteroid Dehydrogenases; D004960:Estradiol Dehydrogenases