Acute myelofibrosis.
This report describes a 20-year-old patient with rapidly fatal fibrosis of the bone marrow associated with leukopenia, anemia, and large number of myeloblasts in peripheral blood. The bone marrow revealed extensive fibrosis and hyperplasia of the myeloblasts and megakaryocytes. The patient failed to respond to chemotherapy, developed fungal and bacterial infections, and died within less than six weeks after the diagnosis was made. The case is reported to support the concept of acute myelofibrosis and to suggest that further cases should be studied to define the clinicopathologic features of this disorder.
D000208:Acute Disease; D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology; D008297:Male; D008533:Megakaryocytes / Q000473:pathology; D009196:Myeloproliferative Disorders / Q000473:pathology; D055728:Primary Myelofibrosis / Q000473:pathology*