title: Benign and malignant types of Parkinson's disease: clinical and patho-physiological characterization.
abstract: Parkinson's disease (P.D.) is characterized by two different types, a benign form found in 85% of patients and a malignant type in 15%. Computer tomography shows malignant patients, in the end stage of the disease process, to exhibit hydrocephalus internus and externus. Such patients exhibit early EEG-deterioration and pharmacotoxic psychosis. The application of neuroleptics to patients with P.D. is associated with an increase in the urinary excretion of acidic metabolites especially of 5-hydroxyindoleacetic acid. It is suggested, that this treatment might also be a useful therapeutic approach to optimizing the residual neuronal function in Parkinson's disease.
mesh_terms: D000368:Aged; D004298:Dopamine / Q000378:metabolism; D004569:Electroencephalography; D006801:Humans; D009638:Norepinephrine / Q000378:metabolism; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed
chemical_list: D004298:Dopamine; D009638:Norepinephrine