Inhibition of immune response by diisopropyl phosphorofluoridate.
Effect of acute, oral intoxication of guinea-pigs and pigs with diisopropyl phosphorofluoridate (DFP) on the level of humoral factors of natural immunity and immunocyte production was studied. The effect of DFP on these animals, expressed by decreased complement and haemolysin activities and diminished number of plaque-forming cells (PFC), was observed only after repeated intoxication. After a single application of DFP statistically significant increase of these parameters were found. In single and multiple treatments, lysozyme activity was somewhat weaker in comparison with control animals.
D000818:Animals; D003165:Complement System Proteins / Q000378:metabolism; D004912:Erythrocytes / Q000276:immunology; D006168:Guinea Pigs; D006460:Hemolysin Proteins / Q000378:metabolism; D007109:Immunity / Q000187:drug effects*; D007114:Immunization; D007531:Isoflurophate / Q000494:pharmacology*; D009113:Muramidase / Q000378:metabolism; D012756:Sheep / Q000276:immunology; D013552:Swine
D006460:Hemolysin Proteins; D007531:Isoflurophate; D003165:Complement System Proteins; D009113:Muramidase