title: On the question of seasonal variations of the carrageenin rat paw edema and of the phenylbutazone effect on it.
abstract: 1. In order to disclose seasonal variations of the strength of the carrageenin rat paw edema as well as of the influence of phenylbutazone on it, experiments of the years 1973-1976 were evaluated arranging th animals by the month. Groups consisted of 10 - 355 rats per month; the total animal number was 3313. 2. It was found that the paw edema volume was highest in June-August and, probably, to a lesser degree in January-February, in comparison to the other months. Percent inhibition of the paw edema volume by phenylbutazone (50 mg/kg p. o. simultaneously with subplantar carrageenin injection) was without significant seasonal variation. 3. The influence of environmental temperature, atmospheric humidity, atmospheric pressure, light intensity, cortisol plasma level, serum calcium, and blood sugar level on inflammatory reactions is briefly discussed in order to find an explanation of the seasonal variations of the carrageenin paw edema volume. Blood sugar and the connected carbohydrate metabolism could best be correlated with the seasonal variations of the paw edema volume.
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced* / Q000188:drug therapy; D005260:Female; D005528:Foot; D009638:Norepinephrine / Q000652:urine; D010653:Phenylbutazone / Q000627:therapeutic use*; D051381:Rats; D012621:Seasons
chemical_list: D002351:Carrageenan; D010653:Phenylbutazone; D002118:Calcium; D009638:Norepinephrine