Dyphylline aerosol can induce bronchospasm in human asthmatics.
Dihydroxypropyl theophylline (dyphylline) was administered by aerosol in a single dose of 250 mg aerosolized over five minutes to two asthmatic volunteers and in a single dose of 375 mg aerosolized over ten minutes to two other asthmatic volunteers. Serial spirometry was then performed. Marked bronchospasm occurred within ten minutes in two of the subjects, and developed more slowly in another. One subject demonstrated no significant change. Aerosolized dyphylline solution was not an effective bronchodilator, using the methods described in this study.
D000328:Adult; D000336:Aerosols; D000368:Aged; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy*; D001986:Bronchial Spasm / Q000139:chemically induced*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004400:Dyphylline / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D013806:Theophylline / Q000031:analogs & derivatives*
D000336:Aerosols; D001993:Bronchodilator Agents; D004400:Dyphylline; D013806:Theophylline