[Changes in the activity of an epileptogenic focus in the hippocampus of rats treated with the chief metabolites of tryptophan].
It has been shown in rats, as previously on frogs, with electrochemotrodes chronically implanted into dorsal hippocampuses that some kynurenine metabolites of tryptophan (quinolinic acid, d, 1-kynurenine) can provoke an increase in the pathological activity of the penicillin-induced epileptogenic focus in the hippocampus. Unlike kynurenines, serotonin, another tryptophan metabolite, and the serotoninomimetic 5-methoxytryptamine suppress the pathological activity of the epileptogenic focus. The results obtained support the hypothesis about a certain role of kynurenines and serotonin in the pathogenesis of epilepsy.
D008735:5-Methoxytryptamine / Q000627:therapeutic use; D000818:Animals; D000927:Anticonvulsants; D006624:Hippocampus / Q000503:physiopathology*; D007737:Kynurenine / Q000627:therapeutic use; D008297:Male; D011805:Quinolinic Acids / Q000627:therapeutic use; D051381:Rats; D012640:Seizures / Q000188:drug therapy*; D012701:Serotonin / Q000627:therapeutic use; D014364:Tryptophan / Q000031:analogs & derivatives*; D062367:ortho-Aminobenzoates / Q000627:therapeutic use
D000927:Anticonvulsants; D011805:Quinolinic Acids; D062367:ortho-Aminobenzoates; C031385:anthranilic acid; D012701:Serotonin; D007737:Kynurenine; D008735:5-Methoxytryptamine; D014364:Tryptophan
Izmenenie aktivnosti épileptogennogo ochaga v gippokampe krys pod vliianiem osnovnykh metabolitov triptofana.