Anticaries and antiplaque potential of free-fatty acids in vitro and in vivo.
The efficacy of several fatty acids as antimicrobial, antiplaque, and anticaries agents, as well as their ability to inhibit hydroxyapatite dissolution were examined. All effectively inhibited bacterial growth. Lauric, linoleic, and oleic acids decreased plaque formation and lauric acid inhibited hydroxyapatite dissolution. When used in the food, lauric acid decreased caries in rats, but not significantly.
D000818:Animals; D001419:Bacteria / Q000187:drug effects; D002327:Cariostatic Agents; D003747:Dental Enamel Solubility / Q000187:drug effects; D003773:Dental Plaque / Q000209:etiology*; D005230:Fatty Acids, Nonesterified / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005503:Food Additives / Q000494:pharmacology; D006882:Hydroxyapatites; D008297:Male; D009067:Mouthwashes / Q000494:pharmacology; D051381:Rats
D002327:Cariostatic Agents; D005230:Fatty Acids, Nonesterified; D005503:Food Additives; D006882:Hydroxyapatites; D009067:Mouthwashes