[HLA tracers and Cushing's syndrome (author's transl)].
HLA-A and B phenotypes were determined in 38 patients with Cushing's syndrome (29 Cushing's diseases, 9 others etiologies) and compared with those of 591 normal subjects. No significant differences was found in the HLA antigens distribution in the two groups. However the series is too small to definitely support the hypothesis of a lack of correlation with HLA. Indeed, the increased prevalence of B8 antigen in Cushing's disease (28%) as compared to that in the control group (17%), although not statistically significant, emphasizes the need for further typing of HLA-DR, particularly RDw3 which is known to be linked to D8 through desequilibrium and associated with several autoimmune diseases.
D003480:Cushing Syndrome / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006801:Humans; D010641:Phenotype
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens
Marqueurs HLA et syndrome de Cushing.