Effect of dithiocarbamate-type chemicals on the nervous system of rats.
Neurotoxic effect of some dithiocarbamate- and thiuram-disulphide-type chemicals as well as CS2 were examined on rat brain and behaviour. A significant reduction of the orientation hypermotility and at the same time a depression of the subcortical EEG activity were observed. The biochemical assay showed a decreased re-formation of norepinephrine. It is suggested that the inhibition of DBH enzyme may be involved in the delayed psychosedative effect, but not in the short-term electrophysiological changes.
D000818:Animals; D001921:Brain / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004569:Electroencephalography; D004837:Epinephrine / Q000378:metabolism; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013859:Thiocarbamates / Q000633:toxicity*
D013859:Thiocarbamates; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine