title: Comparison of the effect of colchicine and vinblastine on the inhibiton of dentinogenesis in rat incisors.
abstract: The quantitative effect of vinblastine, colchicine and lumicolchicine on the rate of dentine formation was determined by chronologically-labelling dentine with the lead salt of EDTA, before and after the intravenous administration of the test drug. Colchicine and vinblastine produced a dose-dependent inhibition of dentine formation. Lumicolchicine had no adverse effect. Although the log dose-response lines of colchicine and vinblastine were parallel, the effect of vinblastine was more potent. The relative potency ratio of vinblastine to colchicine was 1.25-1.70. These results suggest that both colchicine and vinblastine may act at the same site i.e. microtubules, thereby inhibiting the secretion of new dentine matrix.
mesh_terms: D000818:Animals; D003078:Colchicine / Q000494:pharmacology*; D003804:Dentin / Q000033:anatomy & histology / Q000187:drug effects; D003810:Dentinogenesis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007180:Incisor / Q000187:drug effects; D007275:Injections, Intravenous; D008162:Lumicolchicines / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014747:Vinblastine / Q000494:pharmacology
chemical_list: D008162:Lumicolchicines; D014747:Vinblastine; D003078:Colchicine