title: Aberrant Ae (E beta) Ia polypeptide chain in H-2g2 haplotype mice. Possible result of an intragenic recombination or mutation.
abstract: Mice of strains D2.GD and B10.GD, which carry the recombinant haplotype H-2g2 (previously typed as H-2Kd I-Ad / I-Bb I-Jb I-Eb I-Cb Sb H-2Db), have an Ae (E beta) polypeptide chain electrophoretically distinct from the Ae chains of both b and d haplotype mice, including the progenitor strains from which the recombinant H-2g2 chromosome was derived. The evidence presented suggests that the altered molecular properties of the Aeg2 chain may be a consequence of an intragenic recombination event in the I-A subregion within the structural gene for this polypeptide chain. Because the A alpha and A beta chains controlled by H-2g2 appear to be d haplotype in origin, this finding would map the gene for Ae to the right of the loci controlling the A alpha and A beta chains
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D006183:H-2 Antigens / Q000235:genetics*; D006238:Haploidy; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D051379:Mice; D008811:Mice, Inbred DBA; D009154:Mutation; D010455:Peptides / Q000235:genetics*; D011995:Recombination, Genetic
chemical_list: D006183:H-2 Antigens; D000949:Histocompatibility Antigens Class II; D010455:Peptides