The independency of an intact pineal gland of the inhibition by 5-methoxytryptamine of the reproductive organs in the male hamster.
Subcutaneous injections fo 25 micrograms of 5-methoxytryptamine (5-MT) in oil into intact and pinealectomized male hamsters given between 4.30 p.m. and 5 p.m. (light on from 5 a.m. to 7 p.m.; 14 L/10 D) for 54 consecutive days caused involution of the testes. 5-MT, however, is more effective when the pineal is present. These results indicate that melatonin is not the only pineal factor inducing gonadal atrophy in the hamster. 5-MT seems even more effective than melatonin in so far as it is, contrary to melatonin under the same experimental conditions, also effective in the absence of the pineal. Like melatonin, 5-MT appears to be implicated in the control of the reproductive function.
D008735:5-Methoxytryptamine / Q000494:pharmacology*; D000818:Animals; D006224:Cricetinae; D005837:Genitalia, Male / Q000033:anatomy & histology / Q000187:drug effects*; D008297:Male; D008647:Mesocricetus; D009929:Organ Size / Q000187:drug effects; D010870:Pineal Gland / Q000502:physiology*; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects* / Q000473:pathology; D014363:Tryptamines / Q000494:pharmacology*
D014363:Tryptamines; D008735:5-Methoxytryptamine