Pulmonary adenoma response of strain A mice to sulfonic acid derivatives of 1- and 2-naphthylamines.
Various sulfonic acid derivatives of 1-naphthylamine and 2-naphthylamine were tested in inbred A/St (male and female) mice by the pulmonary adenoma bioassay to determine if this class of compounds, used as intermediates in the dye-stuff industry, possesses tumorigenic activity. Neither 1-naphthylamine nor the four sulfonic acid derivatives of 1-naphthylamine tested were tumorigenic. However, 2-naphthylamine and two of the three sulfonic acid derivatives of 2-naphthylamine tested produced statistically significant lung tumor responses at comparable doses. These results indicated that this class of compounds should be examined more extensively for carcinogenic activity.
D015057:1-Naphthylamine / Q000633:toxicity*; D015081:2-Naphthylamine / Q000031:analogs & derivatives / Q000633:toxicity*; D000236:Adenoma / Q000139:chemically induced*; D000818:Animals; D004396:Coloring Agents / Q000633:toxicity; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D009281:Naphthalenes / Q000633:toxicity*; D013451:Sulfonic Acids / Q000633:toxicity*
D004396:Coloring Agents; D009281:Naphthalenes; D013451:Sulfonic Acids; C033152:badische acid; C033153:amido-G-acid; D015057:1-Naphthylamine; D015081:2-Naphthylamine