Blood and urine fluoride concentrations associated with topical fluoride applications on dog gingiva.
The circulatory uptake and urinary excretion of topical fluoride were investigated by applying a sodium fluoride solution containing 18F for six min to healthy gingiva of four adult dogs. Blood and urine samples were taken a regular intervals. Maximal fluoride in blood represented 0.02-0.05% of the applied dose and occurred four min after completion of the application. By 6.0 h, 0.02-0.06% of the applied dose had been excreted in urine. Preliminary data showed that this represented about 8.8% of the fluoride absorbed through the gingiva.
D000818:Animals; D004285:Dogs; D005459:Fluorides / Q000097:blood / Q000378:metabolism* / Q000652:urine; D005460:Fluorides, Topical / Q000008:administration & dosage*; D005461:Fluorine; D005881:Gingiva / Q000378:metabolism; D008297:Male; D011868:Radioisotopes; D012969:Sodium Fluoride / Q000008:administration & dosage; D014070:Tooth / Q000378:metabolism
D005460:Fluorides, Topical; D011868:Radioisotopes; D005461:Fluorine; D012969:Sodium Fluoride; D005459:Fluorides