Mammary tumor induction in male and female Sprague-Dawley rats by adriamycin and daunomycin.
Male and female noninbred Sprague-Dawley rats 30-36 days of age were given single iv injections of 10 or 5 mg adriamycin (Ad)/kg or 10 mg daunomycin (DM)/kg. Multiple mammary tumors (MT), mostly adenocarcinomas, were observed in 29 and 67% of the females given 10 and 5 mg Ad/kg, respectively, and in 64% of those given 10 mg DM/kg. The mean induction time for females receiving 10 mg Ad/kg was 135 days, for those receiving 5 mg/kg it was 114 days, and for those receiving DM it was only 80 days. Single MT, also mostly adenocarcinomas, were observed an average of 279 days from injection in 31% of the males given 5 mg Ad/kg and an average of 91 days from injection in 37% of the males given 10 mg DM/kg. No tumors were observed in the males given 10 mg Ad/kg, but these survived for only 79 days after treatment.
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology; D000232:Adenofibroma / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D003630:Daunorubicin / Q000008:administration & dosage*; D004317:Doxorubicin / Q000008:administration & dosage*; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced; D051381:Rats; D013997:Time Factors
D004317:Doxorubicin; D003630:Daunorubicin