Longitudinal changes of serum lipid and apoB levels in a newborn-infant cohort.
Longitudinal changes in serum apoB levels in relation to serum lipid levels were determined in a subset (n = 30) of a newborn-infant cohort selected from infants (n = 440) of Bogalusa, Louisiana who were born between January 1, 1974 and June 30, 1975. Serum total cholesterol, triglycerides, beta + pre-beta-lipoprotein cholesterol and apoB levels were measured at birth, 6 mo, 1 yr, 2 yr, and 3 yr of age. The mean +/- SD, mg/dl, levels of these variables increased dramatically (p less than 0.0005) from birth to 6 mo (Total cholesterol: 65.0 +/- 15.7 versus 136.3 +/- 27.4; triglycerides: 32.9 +/- 18.9 versus 82.3 +/- 28.9; beta + pre-beta-lipoprotein cholesterol: 31.8 +/- 9.1 versus 87.3 +/- 25.7; apoB: 20.8 +/- 5.3 versus 49.0 +/- 13.5). On the other hand, the ratio of apoB to beta + pre-beta-lipoprotein cholesterol at birth was significantly higher than at 6 months of age (0.69 +/- 0.24 versus 0.58 +/- 0.12, p less than 0.0005). None of the variables changed significantly between 6 mo and 3 yr of age except the increase in serum total cholesterol level from yr 2 to yr 3 (142.6 +/- 26.6 versus 156.4 +/- 23,0, p less than 0.01). A high intra-child year to year correlation for serum apoB was noted beginning at 6 mo of age (r = 0.67, p less than 0.0001); while the apoB levels were proportional to beta + pre-beta-lipoprotein cholesterol levels in some children, others had varied levels of apoB in relation to cholesterol carried by this apoprotein. The fact that apoB levels persist beginning at 6 mo of age and that we are beginning to observe interindividual differences in levels of cholesterol carried by this apoprotein may have clinical implications for coronary artery disease.
D001053:Apolipoproteins / Q000097:blood*; D001055:Apolipoproteins B; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood*; D015243:Cholesterol, VLDL; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008055:Lipids / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D014280:Triglycerides / Q000097:blood
D001053:Apolipoproteins; D001055:Apolipoproteins B; D015243:Cholesterol, VLDL; D008055:Lipids; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol