Genetically dominant resistance in mice to 3-methylcholanthrene-induced lymphoma.
Mice of the RF/J strain are highly susceptible to induction of thymic lymphoma by skin painting with 3-methylcholanthrene (MCA), whereas mice of the 129/J and I/LnJ strains are resistant. Resistance was the dominant trait in F1 mice of crosses of RF with each resistant strain. Analysis of the lymphoma incidence in MCA-painted backcross populations indicated segregation of a single dominant gene for resistance in both crosses. None of these strains show inducibility of the aryl hydrocarbon hydroxylase enzyme system, a phenotype attributed to the dominant Ahb gene which is also known to influence susceptibility to MCA-induced lymphoma. The occurrence of the disease in these backcrosses was independent of the hosts' phenotype at either the H-2 or Fv-1 locus, both of which have shown an influence on susceptibility to murine leukemia virus-associated lymphoma in other experimental systems.
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics; D004790:Enzyme Induction; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics; D007942:Leukemia, Experimental / Q000139:chemically induced / Q000235:genetics; D008223:Lymphoma / Q000139:chemically induced / Q000235:genetics*; D008297:Male; D008748:Methylcholanthrene / Q000633:toxicity*; D051379:Mice; D011110:Polymorphism, Genetic
D006183:H-2 Antigens; D008748:Methylcholanthrene; D001189:Aryl Hydrocarbon Hydroxylases