Systemic availability of ergotamine tartrate in continuous medication.
There seems to be great individual differences in the bioavailability of ergotamine in continuous use. The great tolerance to ergotamine in some patients using the drug on a daily basis, even in high doses, may be due to the low-bioavailability of ergotamine in these subjects. This may also explain the infrequency of serious complications among migraine patients.
D000328:Adult; D001682:Biological Availability; D004878:Ergotamine / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy
D004878:Ergotamine