title: Fanconi's anaemia. Simultaneous onset in 2 siblings and unusual cytological findings.
abstract: Fanconi's anaemia is reported in 2 siblings. The simultaneous onset of pancytopenia after possible exposure to common external agents suggest that both a frail genotype and environmental factors may be etiologically involved in the disorder. One of the children died after having developed a monoblastic leukaemia. This patient disclosed very striking cytological abnormalities, including a dyserythropoietic pattern and ropalocytosis. The physiopathology of the latter abnormality, which has hitherto not been noticed in Fanconi's anaemia, is uncertain.
mesh_terms: D000293:Adolescent; D001792:Blood Platelets / Q000166:cytology; D001853:Bone Marrow / Q000473:pathology / Q000648:ultrastructure; D002648:Child; D002869:Chromosome Aberrations / Q000097:blood; D025063:Chromosome Disorders; D004900:Erythroblasts / Q000648:ultrastructure; D004912:Erythrocytes / Q000166:cytology; D005198:Fanconi Syndrome / Q000097:blood* / Q000209:etiology / Q000235:genetics; D005260:Female; D006098:Granulocytes / Q000166:cytology; D006410:Hematopoiesis; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000097:blood / Q000150:complications; D008297:Male; D010198:Pancytopenia / Q000097:blood / Q000150:complications