title: Systemic availability of ergotamine tartrate in healthy subjects after single and repeated oral doses.
abstract: The studies presented indicate that ergotamine tartrate taken orally in single or repeated 2 mg doses is biologically available in most of the subjects examined. The peak plasma concentration of the drug in the ng/ml range is attained at 1-2 hours. It seems probable that there is a second rise in the plasma concentrations of the drug, possibly indicating an accumulation of ergotamine or some of its immunoreactive metabolites, and this needs further evaluation.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D004878:Ergotamine / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism; D006801:Humans; D011863:Radioimmunoassay
chemical_list: D004878:Ergotamine