Animal models for the study of cancer-induced anorexia.
Walker carcinoma 256/B transplanted sc in CD-COBS rats induce a decrease of food intake when the tumor size is less than 5% of the body weight. This anorexia is accompanied by a decrease of the adipose tissue and, to a lesser extent, of muscular tissue. The mechanism involved in cancer-induced anorexia seems to be different from that of classic centrally acting anorectic agents. Among the drugs tested to counteract this anorexia only cyproheptadine shows a modest effect. Cyclophosphamide reduces tumor growth and prevents decrease in food intake. It is suggested that Walker carcinoma 256/B may be a useful animal model to study problems related to cancer-induced anorexia and cachexia.
D000818:Animals; D000855:Anorexia / Q000209:etiology* / Q000517:prevention & control; D001067:Appetite Depressants / Q000494:pharmacology; D001835:Body Weight; D002100:Cachexia / Q000209:etiology; D002279:Carcinoma 256, Walker / Q000150:complications* / Q000188:drug therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D004435:Eating; D001068:Feeding and Eating Disorders / Q000209:etiology*; D006801:Humans; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000150:complications; D051381:Rats; D011919:Rats, Inbred Strains
D001067:Appetite Depressants; D003520:Cyclophosphamide