Hormonal and immunological aspects of sex steroid-binding plasma protein of primates.
Sex steroid-binding plasma protein binds dihydrotestosterone, testosterone, and oestradiol with high affinity (Kd,eq. approximately 0.5, 1 and 2 nM, respectively), in man (h-SBP) and in monkeys. Steroid-binding specificity is identical in all primates. However oestrone does not displace dihydrotestosterone binding in man or chimpanzee. Gel filtration experiments and immunoelectrophoretic analysis with a mono-specific antiserum raised in the rabbit against h-SBP indicate cross-reactivity with primate SBPs (from complete in chimpanzee and gorilla to weak in prosimians), but no cross-reaction with other mammalian androgen-binding plasma proteins.
D000818:Animals; D000906:Antibodies / Q000276:immunology; D002850:Chromatography, Gel; D003429:Cross Reactions; D013196:Dihydrotestosterone / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007122:Immunoelectrophoresis; D008297:Male; D011247:Pregnancy; D011323:Primates / Q000097:blood* / Q000276:immunology; D012738:Sex Hormone-Binding Globulin / Q000276:immunology / Q000378:metabolism*; D013739:Testosterone / Q000097:blood
D000906:Antibodies; D012738:Sex Hormone-Binding Globulin; D013196:Dihydrotestosterone; D013739:Testosterone; D004958:Estradiol