A deletion in chromosome 1 in cells of a transplantable granulocytic leukemia (GL-13) in guinea pigs.
Chromosomes were examined in leukocytes from a unique transplantable granulocyte leukemia (GL-13) of strain 13 guinea pigs. The GL-13 leukemia has many similarities to human chronic myelogenous leukemia (CML). It has remained predominantly diploid after 90 transplant generations and is characterized cytogenetically by a terminal deletion of the long arm of one of the #1 pair of chromosomes. No other chromosomal abnormality was observed. These findings lend further support to the conclusion that the GL-13 leukemia may be a useful model for the study of human CML.
D000818:Animals; D002872:Chromosome Deletion; D002900:Chromosomes, Human, 1-3; D004171:Diploidy; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007621:Karyotyping; D007942:Leukemia, Experimental / Q000139:chemically induced / Q000235:genetics / Q000473:pathology; D007951:Leukemia, Myeloid / Q000139:chemically induced / Q000235:genetics* / Q000473:pathology; D007962:Leukocytes / Q000648:ultrastructure; D008297:Male; D009368:Neoplasm Transplantation; D009607:Nitrosourea Compounds
D009607:Nitrosourea Compounds; C002738:N-nitrosobutylurea