Conjugation of catecholamines, a variable to be accounted for in human hypertension.
A subgroup of essential hypertensive (EH) patients with high sympathetic tone had low plasma conjugated norepinephrine (NE) and epinephrine (E), but elevated free NE and E and a hyperresponsiveness to various stimuli to the autonomic nervous system. Pheochromocytoma patients could also be divided according to conjugated NE + E levels, this time into normal and elevated conjugated groups. The latter seem to be somewhat protected by the conjugation, showing less free NE and E 'flooding' during hypertensive crises and lower VMA excretion. The degree of catecholamine conjugation can thus modify the sympathetic tone in hypertension.
D000310:Adrenal Gland Neoplasms / Q000503:physiopathology; D000328:Adult; D015239:Arylsulfotransferase; D001794:Blood Pressure; D002395:Catecholamines / Q000378:metabolism*; D004837:Epinephrine / Q000378:metabolism; D005260:Female; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism; D010636:Phenols / Q000378:metabolism; D010673:Pheochromocytoma / Q000503:physiopathology; D010724:Phosphoadenosine Phosphosulfate / Q000378:metabolism; D013466:Sulfurtransferases / Q000378:metabolism; D014642:Vanilmandelic Acid / Q000378:metabolism
D002395:Catecholamines; D010636:Phenols; D010724:Phosphoadenosine Phosphosulfate; D014642:Vanilmandelic Acid; D013466:Sulfurtransferases; D015239:Arylsulfotransferase; D009638:Norepinephrine; D004837:Epinephrine