Analysis of the immunogenetic background of Japanese leprosy patients by the HLA system.
295 lepromatous and 74 tuberculoid leprosy patients were typed for HLA-A, -B and -C and compared to 110 healthy controls. It was found that frequency of HLA-B7 was significantly high and that of Bw54 was significantly low in lepromatous leprosy. HLA-DR and MT types were investigated in 84 lepromatous and 28 tuberculoid patients and compared to 55 controls. Both lepromatous and tuberculoid patients showed a marked increase in DR2 frequency. The relative risk is 8.7 and 5.9. Lepromatous leprosy showed an increase in frequency of MT1 and decreases in those of DRw9 and MT3 too.
D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D007564:Japan; D007918:Leprosy / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D010641:Phenotype
D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II