HLA-B8 antigens and anti-PLa1 allo-immunization.
HLA-A-B-C and DR typing was performed on sixteen individuals whose PLA1 platelet group was negative. Ten of them were immunostimulated with PLA1 antigen by pregnancy or transfusion; six of them were responders and developed an anti-PLA1 antibody. A high incidence of HLA-B8 antigen was observed in that group of responders. This observation is supported by five other cases of allo-immunization reported in previous papers.
D000954:Antigens, Surface / Q000276:immunology; D001792:Blood Platelets / Q000276:immunology*; D001803:Blood Transfusion; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015235:HLA-B Antigens; D006801:Humans; D007518:Isoantibodies / Q000096:biosynthesis
D000954:Antigens, Surface; D006680:HLA Antigens; D015235:HLA-B Antigens; D007518:Isoantibodies