Association of HLA-DRw4 with rheumatoid arthritis in black and white patients.
The HLA-A, B, C, and DR antigens were typed in 35 black and 35 white Americans with rheumatoid arthritis. The frequency of HLA-DRw4 was increased in both the black and white patient patient groups compared to the race-matched control groups. DRw4 was found in 45.7% of the black patients compared to 14.3% of the black controls (corrected P value < 0.035) and DRw4 was found in 71.4% of the white patients compared to 40.0% of the white controls (corrected P value < 0.035). These data indicate that immunogenetic factors related to DRw4 are important in the development of rheumatoid arthritis in American blacks as well as whites.
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D044383:Black People; D006046:Gold / Q000009:adverse effects / Q000627:therapeutic use; D006680:HLA Antigens / Q000032:analysis; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D010396:Penicillamine / Q000009:adverse effects / Q000627:therapeutic use; D012217:Rheumatoid Factor / Q000032:analysis; D014481:United States; D001741:Black or African American
D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II; D006046:Gold; D012217:Rheumatoid Factor; D010396:Penicillamine