title: Relationship between saliva and serum agglutination titers and post-irradiation caries activity in cancer patients.
abstract: Agglutination titers in 444 saliva and 481 serum samples from 36 head and neck cancer patients and 16 control subjects were determined against formalinized cellular antigens of Streptococcus and Lactobacillus species. Saliva agglutination titers were significantly higher in cancer patients before radiotherapy than in control subjects. Changes in specific saliva agglutination titers to oral isolates following radiotherapy reflected changes in saliva IgA and post-irradiation caries activity. Patients with no post-irradiation caries activity had significantly higher saliva agglutination titers to S. mutans, S. sanguis, and L. fermenti, lower plaque S. mutans counts, and higher saliva IgA levels than those with post-irradiation caries activity. Serum agglutination titers were unrelated to either serum immunoglobulin levels, microbial counts, or caries activity.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000371:Agglutination; D000907:Antibodies, Bacterial / Q000032:analysis*; D001769:Blood; D003731:Dental Caries / Q000209:etiology / Q000276:immunology / Q000382:microbiology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007778:Lactobacillus / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000276:immunology*; D013295:Streptococcus mutans / Q000276:immunology; D013298:Streptococcus sanguis / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A