An overview of assay methods for D-penicillamine.
The stability and biotransformation of D-penicillamine as it relates to assay development is discussed. A review of published literature on assays is presented with respect to blood/plasma levels of D-penicillamine in man and to statistical evaluation of assays. Also, the paper describes gas chromatographic assay for D-penicillamine disulfide and L-cysteine D-penicillamine disulfide in urine and plasma, as well as a new high performance liquid chromatography assay for D-penicillamine in plasma.
D001681:Biological Assay / Q000379:methods; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D010396:Penicillamine / Q000097:blood / Q000378:metabolism* / Q000652:urine
D010396:Penicillamine