Linkage disequilibrium between insulin-dependent diabetes and the Kidd blood group Jkb allele.
We studied 102 randomly ascertained probands from the Upper Midwest United States with insulin-dependent diabetes mellitus (IDDM) with respect to both HLA-DR and Kidd (Jk) markers. Based on our evidence that multiple genetic mechanisms may be involved in the etiology of IDDM the data were partitioned according to the HLA-DR phenotype, containing either two high risk antigens (DR3 or DR4) or not. Probands with two such antigens showed no applicable deviation from control frequencies, while the remainder displayed a slightly reduced relative risk for Jka (RR = 0.70, p less than .25), but a significantly elevated risk for Jkb (RR = 2.53, p less than .025). These results strongly suggest a complex model of IDDM inheritance involving, at least, one susceptibility locus in linkage disequilibrium with HLA DR3 and DR4 on chromosome 6, and a second locus in linkage disequilibrium with Jkb on chromosome 2.
D000293:Adolescent; D000328:Adult; D000483:Alleles; D001789:Blood Group Antigens / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007223:Infant; D007667:Kidd Blood-Group System / Q000235:genetics*; D008297:Male
D001789:Blood Group Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D007667:Kidd Blood-Group System