title: Concurrence of metaphyseal fibrous defect and osteosarcoma. Report of a case and review of the literature.
abstract: The case of a 15-year-old girl with juxtaposition of a femoral metaphyseal fibrous defect (fibrous cortical defect) and an osteosarcoma is reported. Despite the relatively common occurrence of metaphyseal fibrous defects, their reported association with other bone tumors is exceedingly rare. Only two previous acceptable examples of this association were found. Reports of malignant transformation of metaphyseal fibrous defect were reviewed and rejected because they lacked convincing radiologic or histopathologic evidence of a pre-existent benign fibrous lesion. The finding of a malignant bone tumor in association with a metaphyseal fibrous defect appears to be a chance occurrence.
mesh_terms: D000293:Adolescent; D001344:Autopsy; D005260:Female; D005266:Femoral Neoplasms / Q000473:pathology*; D005350:Fibroma / Q000473:pathology*; D006801:Humans; D009378:Neoplasms, Multiple Primary; D012516:Osteosarcoma / Q000473:pathology*