Studies of retinoids in the prevention and treatment of cancer.
Investigation of retinoids for anticancer activity in humans, either in the chemopreventive or treatment mode, has been little studied. We summarize here our ongoing investigations in four different areas: (1) secondary prevention of cervical dysplasia with topical application of all-trans-retinoic acid; (2) adjuvant treatment of resected high-risk stage I and II malignant melanoma with bacille Calmette Guérin (BCG) plus or minus oral vitamin A; (3) topical vitamin A acid therapy for cutaneous metastatic melanoma; an (4) oral isotretinoin as an anticancer agent.
D004224:Diterpenes; D005260:Female; D006801:Humans; D007536:Isomerism; D015474:Isotretinoin; D008545:Melanoma / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000517:prevention & control*; D010168:Palmitates / Q000627:therapeutic use; D000084562:Retinyl Esters; D012878:Skin Neoplasms / Q000188:drug therapy; D014212:Tretinoin / Q000627:therapeutic use; D002578:Uterine Cervical Dysplasia / Q000517:prevention & control; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000627:therapeutic use
D004224:Diterpenes; D010168:Palmitates; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate; D014212:Tretinoin; D015474:Isotretinoin