Different patterns of X chromosome inactivity in lymphocytes and fibroblasts of a human balanced X;autosome translocation.
In lymphocytes of a human female carrier of a balanced X;3 translocation, 46,X,t(X;3)(q28;q21), late replication of the structurally normal X chromosome only was previously described (de la Chapelle and Schröder 1973). We have now confirmed this finding using a fresh blood sample. Examining the chromosomes of this individual in fibroblasts we observed that either the normal X or the Xq+ chromosome could replicate late and show inactivity after fusion with heteroploid mouse cells. The replication patterns of chromosomes in human X;autosome translocations have so far almost exclusively been analyzed in lymphocytes. Our findings stress that results based on these cells are not representative for all cell types.
D000818:Animals; D002871:Chromosome Banding; D002900:Chromosomes, Human, 1-3; D004303:Dosage Compensation, Genetic; D005260:Female; D005347:Fibroblasts / Q000648:ultrastructure; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D008214:Lymphocytes / Q000648:ultrastructure; D051379:Mice; D012730:Sex Chromosomes; D014178:Translocation, Genetic; D014960:X Chromosome
D005819:Genetic Markers