Threshold for lead damage to heme synthesis in urban children.
Although lead has no physiological function and is present in only negligible amounts in the blood of remote populations, it has become customary to accept the usual blood Pb level(s) (BPb) observed in industrialized society as "normal." Pb interferes with many biochemical systems, among them the heme biosynthetic pathway; this is reflected by an exponential increase in erythrocyte protoporphyrin concentration (EP) as PBb increases. The present study estimated the threshold PBb at which an increase of EP occurs in a population of urban children. In the 2,004 children studied, BPbs ranged from 2 to 98 micrograms/dl, with 1,852 having a BPb of less than or equal to 30 micrograms/dl, a value presently considered normal. Preliminary analysis suggested that an exponential increase in the concentration of EP occurred after a threshold BPb (apparently between 12 and 20 micrograms/dl) was reached. Precise definition of the threshold BPb for an increase of EP was next determined by two approaches: segmented line techniques and probit analysis. Whether the entire population was analyzed or only the subset of samples with "normal" BPb (less than or equal to 30 micrograms/dl), both methods yielded a threshold BPb of 15-18 micrograms/dl (average value, 16.5). These studies indicate that the heme synthetic pathway is affected by Pb at a level of exposure commonly observed in urban children, which is well below the limit that is presently too easily accepted as normal.
D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D006418:Heme / Q000096:biosynthesis*; D006801:Humans; D007854:Lead / Q000097:blood*; D007855:Lead Poisoning / Q000378:metabolism*; D009519:New York City; D011166:Porphyrins / Q000097:blood*; D011524:Protoporphyrins / Q000097:blood*; D014505:Urban Population
D011166:Porphyrins; D011524:Protoporphyrins; D007854:Lead; D006418:Heme