Clinical relevance of cytotoxic antibodies occurring in pregnancy.
Cytotoxic antibodies were studied in 809 pregnant women's sera. Two kinds of antibody population: HLA-A, B, C and Ia-like, were detected and a correlation was established between their presence and some clinical conditions, such as preterm delivery, spontaneous abortion, pre-eclampsia, neonatal hyperbilirubinaemia and congenital anomalies. An opposite effect of HLA-A, B, C and Ia-like antibodies was observed as far as the first three parameters are concerned. On the basis of these investigations a protective role of Ia-like antibodies for the newborn can be implied.
D000027:Abortion, Incomplete / Q000276:immunology; D000906:Antibodies; D003602:Cytotoxicity, Immunologic; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000276:immunology; D007752:Obstetric Labor, Premature / Q000276:immunology; D011247:Pregnancy
D000906:Antibodies; D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II