[Steroidogenic activity in the amniotic epithelium].
For evaluation of the steroid-producing structures during pregnancy, the human amnion has been studied from the early stages of pregnancy to the term by means of histo-enzymologic and submicroscopic techniques. The histo-enzymatic tests have shown the presence hydroxysteroid of 3 beta-hydroxysteroid-dehydrogenase in the cells of the amniotic epithelium throughout pregnancy. Also scattered mesenchymal cells of the subepithelial fibroblastic layer showed a positive reaction in their cytoplasm. Using FRIEND and BRASSIL's (1970) technique a steroidogenetic activity has been demonstrated at the level of the amniotic epithelium both in semithin and in ultrathin sections, the latter observed by electron microscopy. The above mentioned results suggest that the amniotic epithelium represents a site of steroidogenesis and conversion of steroids and plays, also under this point of view, an important role in the physiology of pregnancy.
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D000650:Amnion / Q000201:enzymology / Q000378:metabolism* / Q000648:ultrastructure; D004848:Epithelium / Q000378:metabolism; D005260:Female; D006801:Humans; D006914:Hydroxysteroids / Q000378:metabolism*; D011247:Pregnancy
D006914:Hydroxysteroids; D015096:3-Hydroxysteroid Dehydrogenases
Activité stéroïdogénétique au niveau de l'épithélium amniotique.