Influence of liver enzyme induction caused by diphenylhydantoin and diazepam on bone mass of rats.
25 albino rats of Wistar strain were used for the study. They were divided into three groups. Animals of the first group (n = 10) were treated with Diphenylhydantoin in a daily dose of 70 mg/kg for three months. Animals of the second group (n = 10) were treated with Diazepam in a daily dose of 10 mg/kg for 3 months. Animals of the third group (n = 5) were treated with 5% acacia oil for the same period of time. Food and water consumption together with motor activity were measured. As indices of enzyme induction, D-Glucaric acid and liver weight were determined. Also the following bone indices were determined: femur Ca/femur weight, femur Ca/body weight, humerus Ca/humerus weight, humerus Ca/body weight, femur specific weight, humerus specific weight. Statistically significant alterations of bone mass were found.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001846:Bone Development; D001842:Bone and Bones / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D003975:Diazepam / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects*; D005937:Glucaric Acid / Q000652:urine; D008099:Liver / Q000201:enzymology*; D009929:Organ Size / Q000187:drug effects; D010672:Phenytoin / Q000494:pharmacology*; D051381:Rats
D010672:Phenytoin; D003975:Diazepam; D005937:Glucaric Acid; D002118:Calcium