title: In vivo enamel fluoride uptake from and caries inhibition by topical fluoride agents.
abstract: Acidulated phosphate fluoride (APF), Duraphat or Fluor Protector, was applied to the molar teeth of rats fed a cariogenic diet. The first maxillary molar teeth were subjected to a microbiopsy procedure for fluoride analysis and the mandibular molars scored for caries. All three topical fluoride agents produced a significant increase in the fluoride content of the outermost 5.0 micron of enamel. Only APF produced a significant reduction in caries incidence at all sites.
mesh_terms: D000149:Acidulated Phosphate Fluoride / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D002124:Calcium Fluoride / Q000378:metabolism; D003731:Dental Caries / Q000517:prevention & control*; D003743:Dental Enamel / Q000378:metabolism*; D004338:Drug Combinations / Q000378:metabolism; D005460:Fluorides, Topical / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D011140:Polyurethanes / Q000378:metabolism; D051381:Rats; D012821:Silanes / Q000378:metabolism; D012969:Sodium Fluoride / Q000378:metabolism
chemical_list: D004338:Drug Combinations; D005460:Fluorides, Topical; D011140:Polyurethanes; D012821:Silanes; C023807:sodium fluoride topical preparation; D000149:Acidulated Phosphate Fluoride; C022599:Fluor Protector; D012969:Sodium Fluoride; D002124:Calcium Fluoride