Gangliocytoma of third ventricle: hyperphagia, somnolence, and dementia.
A 55-year-old man had hydrocephalus caused by a third-ventricular tumor. Mentation improved after ventricular shunting and radiation therapy. Progressive hyperphagia, obesity, memory impairment, and hypersomnolence developed 13 months later, and he died 2 years after diagnosis. At necropsy, a gangliocytoma filled the third ventricle, resulting in compression and necrosis of the ventromedial and posterior hypothalamic nuclei. Clinical manifestations were attributed to these lesions.
D002551:Cerebral Ventricle Neoplasms / Q000150:complications* / Q000473:pathology; D003704:Dementia / Q000209:etiology*; D001068:Feeding and Eating Disorders / Q000209:etiology*; D005729:Ganglioneuroma / Q000150:complications* / Q000473:pathology; D006801:Humans; D006963:Hyperphagia / Q000209:etiology*; D007031:Hypothalamus / Q000473:pathology; D008297:Male; D008569:Memory Disorders / Q000209:etiology; D008875:Middle Aged; D012893:Sleep Wake Disorders / Q000209:etiology*