Effect of two doses of pirenzepine on histamine-stimulated gastric acid secretion in man.
The effect of two dose-schedules of Pirenzepine (25 mg b.d. or 50 mg t.d.s. during 2 1/2 days) on histamine-stimulated gastric acid secretion was tested in eleven healthy volunteers. Gastric secretory responses were calculated as acid output values and as VG-values (VG = gastric secretory volume corrected for duodeno-gastric reflux and pyloric loss). Stimulated acid output per two hours was reduced with Pirenzepine 25 mg b.d. by 12.5% (n.s.), with Pirenzepine 50 mg t.d.s. by 21% (p less than 0.01). Stimulated VG per two hours was reduced with Pirenzepine 25 mg b.d. by 15.8% (p less than 0.01) and with Pirenzepine 50 mg t.d.s. by 24% (p less than 0.01). Pirenzepine reduces histamine-stimulated gastric acid output to a similar degree as other anticholinergic drugs. Reduction seems to be due to true inhibition of acid secretion and not to altered gastric motility.
D000293:Adolescent; D000328:Adult; D001570:Benzodiazepinones / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010890:Pirenzepine; D013268:Stimulation, Chemical
D001570:Benzodiazepinones; D010890:Pirenzepine; D006632:Histamine