Cytological and DNA-cytophotometric monitoring of the effect of therapy in conservatively treated prostatic carcinomas.
A total of 464 aspiration biopsies were carried out on 180 patients with variously treated prostatic carcinomas. Characteristic signs of regression could be detected cytomorphologically in the cell nucleus and cytoplasm, which permitted 6 different regression grades to be distinguished. Analysis of 102 punch and aspiration biopsies, carried out for the first time simultaneously, revealed a diagnostic reliability of at least 97%. The incidence of complications on aspiration biopsy was 1.7%. In 30 cases additional prospective single cell DNA determinations were carried out on advanced prostatic carcinomas undergoing treatment. It could be shown that tumors with extensive aneuploidization and lack of change in the ploidal distribution in response to treatment showed poor clinical progress whereas those in which a change from aneuploidy to euploidy became apparent, showed good clinical progress.
D001707:Biopsy, Needle; D004273:DNA, Neoplasm / Q000378:metabolism*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000648:ultrastructure*
D004273:DNA, Neoplasm