title: Binding of prostaglandins E1 (alprostadil), E2 (dinoprostone), F1 alpha, and F2 alpha (dinoprost) to human serum proteins.
abstract: Prostaglandins E1 (alprostadil), E2 (dinoprostone), F1 alpha, and F2 alpha (dinoprost) were characterized in terms of binding to human serum, albumin, gamma-globulin II, beta-globulin III, alpha-globulin IV-1, and alpha-globulin IV-4. By using equilibrium dialysis and tritium-labeled ligands, the percent binding for all four ligands was found to decrease in the following order: human serum, albumin, and alpha-globulin IV-4. For the other three proteins, the order was not consistent with the four ligands, and less than 10% binding was observed. In general, prostaglandins E1 and E2 showed a higher percent binding for all fractions than prostaglandins F1 alpha and F2 alpha. All four ligands can be characterized as showing significant binding to human serum, albumin, and alpha-globulin IV-4.
mesh_terms: D000527:Alprostadil; D001798:Blood Proteins / Q000378:metabolism*; D015237:Dinoprost; D015232:Dinoprostone; D006801:Humans; D011458:Prostaglandins E / Q000097:blood*; D011460:Prostaglandins F / Q000097:blood*; D011485:Protein Binding
chemical_list: D001798:Blood Proteins; D011458:Prostaglandins E; D011460:Prostaglandins F; D015237:Dinoprost; D000527:Alprostadil; D015232:Dinoprostone; C100006:prostaglandin F1