Mutagen sensitivity of kynureninase mutants of the nematode Caenorhabditis elegans.
Mutants in the gene flu-2 of the free-living nematode Caenorhabditis elegans are characterised by an altered autofluorescence of the intestine cells, from the light blue of wild-type to a dull green colour. The properties of flu-2 mutants have been investigated. L-kynureninase activity has been detected in wild-type C. elegans. The flu-2 mutants have markedly reduced kynureninase activity, as predicted earlier from chromatographic analysis of tryptophan catabolites of wild-type and mutant worms. Associated with this enzymatic block, all flu-2 mutants have enhanced sensitivity to ethyl methane sulfonate (EMS) and gamma-rays.
D000818:Animals; D002107:Caenorhabditis / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects; D005020:Ethyl Methanesulfonate / Q000494:pharmacology; D005720:Gamma Rays; D006867:Hydrolases / Q000235:genetics*; D009154:Mutation; D010641:Phenotype
D005020:Ethyl Methanesulfonate; D006867:Hydrolases; C021480:kynureninase