Phenotypic differences among the alleles of the T4 recombination defective mutants.
The allelic forms of the phage genes T4 chi and fdsA, as well as T4y and fdsB are compared in terms of their thymidine incorporation in high or low concentrations of thymidine, sensitivity of DNA synthetic capacity to mitomycin C, and sedimentation rates of DNA replicative intermediates. The results show differences among these mutants for the incorporation of thymidine; however all exhibit mitomycin C-sensitive DNA synthesis and have identical aberrant sedimentation rates for their DNA replicative intermediates.
D000483:Alleles; D004261:DNA Replication; D004279:DNA, Viral / Q000096:biosynthesis / Q000378:metabolism; D005814:Genes, Viral; D008937:Mitomycins / Q000494:pharmacology; D009154:Mutation; D010641:Phenotype; D011995:Recombination, Genetic; D013604:T-Phages / Q000187:drug effects / Q000235:genetics*; D013936:Thymidine / Q000378:metabolism
D004279:DNA, Viral; D008937:Mitomycins; D013936:Thymidine