title: Acute myelofibrosis terminating in an acute lymphoblastic leukemia: a case report.
abstract: A patient with acute myelofibrosis developed acute leukemia during the course of her disease. Light microscopic examination showed that the cells were lymphoblasts. The presence of terminal deoxynucleotidyl transferase and T- and B-lymphocyte markers suggested that the malignancy was of immature lymphoid cell origin. Terminal leukemic transformation in some cases of acute myelofibrosis may be of a lymphoid nature and, thus, less toxic chemotherapy could be used with a better prognosis.
mesh_terms: D000954:Antigens, Surface / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology; D004254:DNA Nucleotidyltransferases / Q000032:analysis; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010198:Pancytopenia / Q000209:etiology; D055728:Primary Myelofibrosis / Q000097:blood / Q000150:complications* / Q000473:pathology; D011379:Prognosis
chemical_list: D000954:Antigens, Surface; D004254:DNA Nucleotidyltransferases