Regulation of ketone body metabolism and the effects of injury.
The role of extra- and intra-hepatic factors in the regulation of ketone body synthesis by the liver is briefly reviewed. Possible reasons for the absence of hyperketonaemia in the majority of subjects in the immediate post-injury period are discussed. Recent findings that vasopressin can inhibit ketogenesis in vitro are presented and it is postulated that raised concentrations of this hormone may play a role in preventing hyperketonaemia in injured subjects.
D050260:Carbohydrate Metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005246:Feedback; D006728:Hormones / Q000494:pharmacology; D006801:Humans; D007657:Ketone Bodies / Q000378:metabolism*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D014947:Wounds and Injuries / Q000378:metabolism*
D005230:Fatty Acids, Nonesterified; D006728:Hormones; D007657:Ketone Bodies