The effects on extraction wound healing of a new drug combination introduced for use in the prevention of post-extraction complications. A preliminary report.
Fifteen extraction sockets packed with a new drug combination which includes a local anaesthetic (cincain chloride), a local antiseptic (tri-iodomethane) and two drugs with a potent antifibrinolytic activity (tranexamic acid and propyl-hydroxy-benzoic acid) in an absorbable gelatin sponge (Gelfoam) as a vehicle, were histologically assessed with special reference to the parameters related to wound healing. As a control, the same number of sockets were allowed to heal spontaneously and similarly assessed. Healing of the extraction wounds seemed to follow the normal sequence in both series, and no histological signs suggestive of a delay in the healing process could be found in any of the sockets studied. Also the mast cell count previously considered to be of importance in the connective tissue repair was found to be unaffected by the test substance. These results, together with the previously presented data on the clinical efficacy of the drug combination studied, suggest that a larger clinical study should be carried out to assess its value as a preventive measure against the development of the post-extraction symptoms, including dry socket.
D000293:Adolescent; D000328:Adult; D000539:Alveolar Process / Q000033:anatomy & histology / Q000502:physiology*; D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D000933:Antifibrinolytic Agents / Q000494:pharmacology; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D003992:Dibucaine / Q000494:pharmacology*; D004338:Drug Combinations; D006801:Humans; D006847:Hydrocarbons, Iodinated / Q000494:pharmacology*; D008875:Middle Aged; D010226:Parabens / Q000494:pharmacology*; D011183:Postoperative Complications / Q000517:prevention & control*; D014081:Tooth Extraction / Q000009:adverse effects*; D014148:Tranexamic Acid / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects
D000891:Anti-Infective Agents, Local; D000933:Antifibrinolytic Agents; D003509:Cyclohexanecarboxylic Acids; D004338:Drug Combinations; D006847:Hydrocarbons, Iodinated; D010226:Parabens; D014148:Tranexamic Acid; C010473:iodoform; D003992:Dibucaine; C006068:propylparaben