Comparison of the carcinogenicity of methylazoxymethanol-beta-D-glucosiduronic acid in conventional and germfree Sprague-Dawley rats.
Methylazoxymethanol-beta-D-glucosiduronic acid (MAM-GlcUA) was administered to young adult male Sprague-Dawley rats by oral and ip routes. Most neoplasms developed in rats that had received the compound orally. The most prevalent site for the neoplasms was the intestinal tract, predominantly the colon. Comparatively fewer tumors occurred in the liver and kidneys. Germfree rats did not develop tumors when MAM-GlcUA was administered either orally or ip.
D000284:Administration, Oral; D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D002273:Carcinogens; D003492:Cycasin / Q000008:administration & dosage / Q000633:toxicity*; D005856:Germ-Free Life; D007274:Injections, Intraperitoneal; D007414:Intestinal Neoplasms / Q000139:chemically induced; D007680:Kidney Neoplasms / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D051381:Rats
D001391:Azo Compounds; D002273:Carcinogens; D003492:Cycasin