title: Activity of steroid sulfatase in fibroblasts with numerical and structural X chromosome aberrations.
abstract: In cultured fibroblasts of patients with numerical and structural X chromosome aberrations the activity of steroid sulfatase (STS) is correlated with the number of functional STS gene copies. While normally, this X-linked gene is not inactivated, our data suggest that it may be subject to inactivation when carried on a structurally altered X-chromosome. Similar inactivation patterns have been reported earlier for the Xg locus which, like STS, is located on the distal portion of Xp.
mesh_terms: D002478:Cells, Cultured; D004303:Dosage Compensation, Genetic; D005260:Female; D006801:Humans; D012729:Sex Chromosome Aberrations / Q000201:enzymology* / Q000235:genetics; D012730:Sex Chromosomes; D012867:Skin / Q000201:enzymology; D043266:Steryl-Sulfatase; D013429:Sulfatases / Q000235:genetics / Q000378:metabolism*; D014960:X Chromosome
chemical_list: D013429:Sulfatases; D043266:Steryl-Sulfatase