[Evaluation of the proliferative activity of hematopoietic cells in preleukemic syndromes].
The Authors have studied bone marrow CFUc and CLFC of 8 cases affected by idiopathic myelofibrosis, 7 by chronic granulocytic leukemia, 6 by polycythemia, and 3 by sideroblastic anemia. The authors studied also C.S.F. activity in peripheral blood of 8 cases. The method of Pike and Robinson for in agar culture was utilized. The results indicated a correlation between increase of clusters/colonies fraction, growth of blasts-like clusters, reduction of C.S.F. activity in peripheral blood and transformation in acute leukemia of preleukemic syndromes.
D000328:Adult; D000368:Aged; D000743:Anemia, Hemolytic / Q000503:physiopathology; D001853:Bone Marrow / Q000503:physiopathology*; D002452:Cell Count; D002555:Cerebrospinal Fluid / Q000166:cytology; D003114:Colony-Forming Units Assay; D006410:Hematopoiesis; D006801:Humans; D007951:Leukemia, Myeloid / Q000503:physiopathology; D007958:Leukocyte Count; D007962:Leukocytes; D008875:Middle Aged; D010976:Platelet Count; D011087:Polycythemia Vera / Q000503:physiopathology; D011289:Preleukemia / Q000503:physiopathology*; D055728:Primary Myelofibrosis / Q000503:physiopathology
Valutazione dell'attività proliferativa delle cellule emopoietiche nelle sindromi preleucemiche.