title: Quantitation of experimental postsurgical edema.
abstract: Many oral surgical procedures are followed by varying degrees of edema. Although numerous methods of minimizing swelling have been advocated, no technique has gained complete acceptance. A major problem has been the inability to document the efficacy of suggested treatments convincingly. The present study quantitates edema by measuring differences in percentage of water content between operated and unoperated tissues over a period of one week. Percentage difference in water content peaked by 48 to 72 hours and was followed by gradual resolution. By use of this model system, a steroid-induced, dose-dependent suppression of postsurgical swelling was confirmed.
mesh_terms: D000818:Animals; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology; D004487:Edema / Q000473:pathology* / Q000517:prevention & control; D011183:Postoperative Complications / Q000473:pathology / Q000517:prevention & control; D011817:Rabbits; D013515:Surgery, Oral / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D003907:Dexamethasone