Elevated mitotic number in the adrenal cortex as a reflection of early events in growth induction by carcinogens and promoters--a possible short-term assay.
Growth stimulating influences such as partial hepatectomy, chemical promoters and various carcinogens act mitogenically on the adrenal cortex of rats. The proliferative response of this 'non-target' tissue is probably due to systemically operating mechanisms which are independent of the organotropism of a substance. Therefore, this in vivo test appears useful for short-term evaluation of the promoting action of chemical compounds.
D000302:Adrenal Cortex / Q000648:ultrastructure*; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D008115:Liver Regeneration; D008297:Male; D008938:Mitosis; D008940:Mitotic Index; D051381:Rats
D002273:Carcinogens