An incremental-dose combined oestrogen-progestogen oral contraceptive: cycle control and endometrial changes.
A study of bleeding patterns and endometrial histology was made in women using an incremental-dose combined oestrogen-progestogen formulation. The proliferative activity during the first 11 days of treatment was less well-developed, and there was an early appearance of secretory changes (transitional pattern). The increased dose of d-norgestrel resulted in an endometrium showing either early or deficient secretory changes. Menstrual patterns were very satisfactory in terms of cycle length and duration of bleeding.
D001706:Biopsy; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology*; D004717:Endometrium / Q000033:anatomy & histology / Q000187:drug effects*; D005260:Female; D006801:Humans; D008598:Menstruation / Q000187:drug effects*
D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined