title: Effect of stannous fluoride treatments on the progression of initial lesions in approximal surfaces of permanent posterior teeth.
abstract: Bite-wing radiographs were used to determine the effect of three forms of topical SnF2 therapy on the progression of initial lesions in the approximal surfaces of permanent posterior teeth. Radiographs were taken annually over a four-year period. The subjects were schoolchildren, aged 12-14 yr, living in a low fluoride area. The professional application of a 10% SnF2 solution for 30 s, semi-annually for two yr, had no discernible effect on the development of the initial lesions. However, the home use of a SnF2 dentifrice did inhibit caries progression appreciably at all but one of the four time intervals in the study. The professional application of a 10% SnF2 solution for 30 s, semi-annually for two yr, combined with the home use of a SnF2 dentifrice, was the most effective treatment in retarding lesion development. Even without topical fluoride therapy, the rate of progression of initial approximal lesions was generally quite slow. In view of these findings, it would seem sound clinical practice to treat all initial lesions in approximal surfaces with topical fluoride therapy and delay placement of restorations until there is radiographic evidence of lesions reaching dentin.
mesh_terms: D000293:Adolescent; D002648:Child; D003731:Dental Caries / Q000000981:diagnostic imaging / Q000517:prevention & control*; D003802:Dentifrices / Q000627:therapeutic use*; D005260:Female; D005459:Fluorides / Q000627:therapeutic use*; D005460:Fluorides, Topical / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011859:Radiography; D011897:Random Allocation; D013997:Time Factors; D014002:Tin Fluorides / Q000627:therapeutic use*; D014070:Tooth / Q000000981:diagnostic imaging
chemical_list: D003802:Dentifrices; D005460:Fluorides, Topical; D014002:Tin Fluorides; D005459:Fluorides