Carcinogenicity of nitrosotrialkylureas in Fischer 344 rats.
Three nitrosotrialkylureas were administered to female F344 rats as approximately 1-mM solutions in drinking water. Nitrosotrimethylurea, given for 47 weeks, gave rise to astrocytomas of the brain and tumors of the forestomach; nitrosotriethylurea induced a high incidence of adenocarcinomas of the breast and uterus and tumors of the forestomach. Nitrosomethyldiethylurea induced almost exclusively a high incidence of both astrocytomas of the brain and tumors of the spinal cord.
D000818:Animals; D001254:Astrocytoma / Q000139:chemically induced; D001932:Brain Neoplasms / Q000139:chemically induced; D002273:Carcinogens; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005260:Female; D008770:Methylnitrosourea / Q000031:analogs & derivatives*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009607:Nitrosourea Compounds / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D013120:Spinal Cord Neoplasms / Q000139:chemically induced; D013274:Stomach Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D009607:Nitrosourea Compounds; C026467:trimethylnitrosourea; C026465:triethylnitrosourea; C026466:diethylmethylnitrosourea; D008770:Methylnitrosourea