Influence of flavonoids on capillary permeability, carrageenin edema and histamine and PGE2 spasms.
Bioflavonoids from propolis and 6-halogenated flavanones were tested with respect to their effects on increased capillary permeability and to their antiinflammatory and antispasmodic actions, respectively. The 5,7,8-trimethoxy- and 6-fluorflavanone seem to be the best compounds tested.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects*; D002351:Carrageenan; D015232:Dinoprostone; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005419:Flavonoids / Q000494:pharmacology*; D006168:Guinea Pigs; D006632:Histamine; D066298:In Vitro Techniques; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology*; D011458:Prostaglandins E; D051381:Rats; D011919:Rats, Inbred Strains; D013035:Spasm / Q000139:chemically induced / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D005419:Flavonoids; D010276:Parasympatholytics; D011458:Prostaglandins E; D006632:Histamine; D002351:Carrageenan; D015232:Dinoprostone