title: Endotoxin enhanced adjuvant effect of liposomes, particularly when antigen and endotoxin are incorporated within the same liposome.
abstract: Endotoxin has been shown to enhance the adjuvant effect of liposomes to protein antigens. When a weak antigen and endotoxin were associated with the same liposomes, antibody production could be detected 3 days (72 hours) after injection of the antigen-liposome-endotoxin preparation. When antigen and endotoxin were associated with different liposomes and these antigen-liposome and endotoxin-liposome preparations were injected simultaneously, the adjuvant effect of the liposomes was enhanced also, but not enough to detect antibody production on day 3.
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000941:Antigens / Q000378:metabolism; D004731:Endotoxins / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D000949:Histocompatibility Antigens Class II; D008081:Liposomes / Q000276:immunology* / Q000378:metabolism; D008297:Male; D011817:Rabbits
chemical_list: D000276:Adjuvants, Immunologic; D000941:Antigens; D004731:Endotoxins; D000949:Histocompatibility Antigens Class II; D008081:Liposomes