Effect of 5-methoxytryptophan and 5-methoxytryptamine on the reproductive system of the male golden hamster.
S.c. injection of 25 microgram of methoxytryptamine (5-MT) in oil into adult male hamsters given between 4.30 and 5 p.m. (light on from 5 a.m. to 7 p.m.: 14 L/10 D) for 51 consecutive days caused involution of the testes. Similar injections of 5-MT given between 8.30 and 9.30 a.m. completely failed to cause regression of the gonads. Under the same conditions, 5-methoxytryptophan (5-MTP) did not induce gonadal atrophy, neither in the morning nor in the late afternoon. These results indicate that, like malatonin, 5-methoxytryptamine is implicated in the control of the reproductive function.
D008735:5-Methoxytryptamine / Q000494:pharmacology*; D000818:Animals; D006224:Cricetinae; D008297:Male; D008647:Mesocricetus; D009929:Organ Size / Q000187:drug effects; D012098:Reproduction / Q000187:drug effects*; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects*; D014363:Tryptamines / Q000494:pharmacology*; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000494:pharmacology
D014363:Tryptamines; C027986:5-methoxytryptophan; D008735:5-Methoxytryptamine; D014364:Tryptophan