Comparative studies on the kinin-forming system in the bone marrow punctates and in the peripheral blood in cases of certain hematological diseases.
In three groups of patients with hypochromic anemia, chronic myelocytic leukemia and chronic lymphatic leukemia, the fibrinolytic activity, kininogen level and kininase activity in the peripheral blood and bone marrow punctates were analyzed. In patients with anemia and myelocytic leukemia similar, unchanged kininase activity, significantly higher fibrinolytic activity and lower kininogen content were found in bone marrow as compared to the peripheral blood samples. In cases of lymphatic leukemia the fibrinolytic activity and kininogen levels did not show significant difference in the blood and bone marrow, while a significantly decreased blood kininase activity was followed by a similarly low activity of the bone marrow punctate. The differences found may result from an enzymatic effect of juvenile forms of granulocytes and of the lymphoreticular system.
D000328:Adult; D000368:Aged; D000747:Anemia, Hypochromic / Q000097:blood / Q000378:metabolism*; D001853:Bone Marrow / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D007610:Kallikreins / Q000378:metabolism*; D007704:Kininogens / Q000378:metabolism*; D007945:Leukemia, Lymphoid / Q000097:blood / Q000201:enzymology / Q000378:metabolism*; D007951:Leukemia, Myeloid / Q000097:blood / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D007704:Kininogens; D007610:Kallikreins