A new mechanism for the regulation of platelet functional state.
A study has been performed on the effects of alternating pressure on the functional state of circulating platelets. Platelet aggregation, changes in platelet shape and the time of shape recovery after deformation have been measured, as well as plasma adenine nucleotide concentrations. A pressure impulse of 60--80 Torr applied for 1 min causes a 50% decrease in the extent of platelet aggregation, but if 110--120 Torr is applied, the amplitude of platelet aggregation is increased by 50%. With pressure impulses increasing to 350 Torr, the peak of aggregation process was recorded, with subsequent inhibition as the alternating pressure grew further. The possible physiological significance of these findings is discussed.
D000255:Adenosine Triphosphate / Q000097:blood; D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D010974:Platelet Aggregation; D011312:Pressure; D011817:Rabbits; D013997:Time Factors
D000255:Adenosine Triphosphate