Binding of eugenol and o-ethoxybenzoic acid to bovine serum albumin.
The binding constants (log K) of eugenol, o-ethoxy-benzoic acid, and their analogues, plus other organic compounds widely used in dentistry with bovine serum albumin, were examined with respect to the partition coefficients of these compounds in octanol-water (log P). Linear relationships between log K and log P values were obtained with high relative coefficients. Eugenol and o-ethoxybenzoic acid showed a relatively large log K value.
D000438:Alcohols / Q000494:pharmacology; D000447:Aldehydes / Q000494:pharmacology; D001391:Azo Compounds; D002264:Carboxylic Acids / Q000494:pharmacology; D005054:Eugenol / Q000378:metabolism*; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates / Q000378:metabolism*; D010636:Phenols / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects; D012710:Serum Albumin, Bovine / Q000378:metabolism*
D000438:Alcohols; D000447:Aldehydes; D001391:Azo Compounds; D002264:Carboxylic Acids; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates; D010636:Phenols; C029266:2-ethoxybenzoic acid; C001413:HABA; D012710:Serum Albumin, Bovine; C015199:ethoxybenzoic acid; D005054:Eugenol