Four to seven-year follow-up of patients on prazosin. New Zealand Hypertension Study Group.
The progress of 172 hypertensive patients who were taking prazosin at the end of a multicentre study in March 1976 was re-surveyed in 1979. Three patients could not be traced. Mean duration of prazosin treatment in the remainder was 57 months. One hundred and ten patients were still taking prazosin; blood pressure control was good and there was no evidence of the development of tolerance. Mean daily dose was 9 mg. Fifty-nine patients had stopped the drug; 16 of these had died, mainly of cardiac causes, 21 had stopped because of possible or probable side effects and 22 for other reasons. No long-term toxic effects have become apparent.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009520:New Zealand; D011224:Prazosin / Q000627:therapeutic use*; D011674:Pulse / Q000187:drug effects; D011799:Quinazolines / Q000627:therapeutic use*
D011799:Quinazolines; D011224:Prazosin