Studies on the effect of D-penicillamine on type II collagen-induced polyarthritis.
The effect of D-penicillamine on a preestablished lesion of type II collagen-induced polyarthritis is reviewed. D-penicillamine treatment (100 and 200 mg/kg/d)for 21 d had no significant effect on rat hind paw inflammation associated with this polyarthritis. At the lower dose, the drug caused an increase in circulating antibody titers to type II collagen. X-ray examination of the hind paws of D-penicillamine-treated animals showed a significant improvement in the joint lesions induced by type II collagen.
D000818:Animals; D001168:Arthritis / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000188:drug therapy*; D003094:Collagen / Q000494:pharmacology; D004195:Disease Models, Animal; D008297:Male; D010396:Penicillamine / Q000627:therapeutic use*; D011859:Radiography; D051381:Rats
D003094:Collagen; D010396:Penicillamine