HLA phenotypes in Mexican Americans with tuberculosis.
HLA-A, -B, and -C phenotype distributions in 100 Mexican Americans with active tuberculosis were compared with HLA phenotypes in 50 healthy, tuberculin-skin-test-positive and 50 healthy, tuberculin-skin-test-negative Mexican Americans. Although there existed differences in the phenotype frequencies of 5 antigens (Aw30, Aw33, B7, B15, and B17) among the 3 study groups, these differences were not significant using p values that were corrected for the number of antigens tested. Thus, susceptibility (or resistance) to tuberculosis in Mexican Americans does not appear to be linked to a specific HLA-A, -B, or -C phenotype.
D000328:Adult; D006680:HLA Antigens / Q000032:analysis*; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006630:Hispanic or Latino; D006801:Humans; D008800:Mexico / Q000208:ethnology; D008875:Middle Aged; D010641:Phenotype; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000276:immunology*; D014481:United States
D006680:HLA Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens