An evaluation of the toxicity of thiuram in combination with other pesticides.
Combined action of Thiuram with Carbaryl, Propoxur, Pirimor, Chlorfenvinphos, Malathion, Lindane, and Carbendazine was investigated in rats. The effects induced by Thiuram containing combinations were stronger in females than in males. The type of response was differentiated in each individual case. In rats receiving Chlorfenvinphos or Carbendazine with Thiuram the effects were on the borderline between more than additive and potentiated toxicity in males, while in females potentiation was observed. In the case of the combination with Propoxur the effects appeared to be less than additive in males and strictly additive in females. Other tested combinations exerted additive action in males, while in females effects ranged from additive to potentiating toxicity. It is evident, that combined action of Thiuram with some pesticides might have resulted in potentiation of toxicity. Hence, this fact ought to be considered in evaluation of Thiuram containing multicomponent pesticidal preparations that are to be introduced into practical use.
D000818:Animals; D004347:Drug Interactions; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D010575:Pesticides / Q000633:toxicity*; D051381:Rats; D013859:Thiocarbamates / Q000633:toxicity*; D013893:Thiram / Q000633:toxicity*
D010575:Pesticides; D013859:Thiocarbamates; D013893:Thiram