Investigations on hormone dependency of human mammary carcinomas transplanted into nude mice.
Since human mammary cancer can be transplanted into nude mice, this makes possible the in vivo study of relations between hormone dependency and the steroid hormone receptor content of the tumors. The macroscopic growth curve of the transplanted tumors during endocrine therapy will reflect the hormone dependency. The results can be compared with successive steroid hormone receptor determinations in the tumor tissue.
D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy / Q000503:physiopathology*; D004967:Estrogens / Q000502:physiology*; D005260:Female; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011374:Progesterone / Q000502:physiology*; D011987:Receptors, Steroid / Q000032:analysis; D014183:Transplantation, Heterologous
D004967:Estrogens; D011987:Receptors, Steroid; D011374:Progesterone