Non-specific cross-reacting antigen serum concentration in myeloid leukemias.
Non-specific cross-reacting antigen (NCA) was assayed radioimmunologically in normal sera and sera obtained from patients with chronic and acute myeloid leukemias. Normal value for NCA concentration was 37.8 ng/ml with a standard deviation of 14.6. In patients with chronic myeloid leukemia NCA serum concentration was significantly increased, and a study with regard to the stage of the disease (acute phase, blastic crisis, remission) was made. Individual cases were studied longitudinally. Patients with acute myeloid leukemias had a lower value than normal. The influence of chemotherapy on NCA serum concentration and the interest of NCA assay for follow-up of the patients are discussed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000941:Antigens / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003429:Cross Reactions; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D000941:Antigens