Hypothiocyanite ion: detection of the antimicrobial agent in human saliva.
The median concentration of hypothiocyanite (OSCN-) in freshly collected whole saliva was 10 microM. The OSCN- concentration increased to a median value of 36 microM during incubation for one h at 37 degrees in vitro. This increase was partially inhibited by adding certain sugars (especially sucrose). The results suggest that OSCN- is a naturally occurring component of human saliva. Also, dietary carbohydrate may inhibit OSCN- accumulation and antimicrobial action in saliva.
D000328:Adult; D000890:Anti-Infective Agents / Q000032:analysis* / Q000037:antagonists & inhibitors / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010544:Peroxidases / Q000502:physiology; D012463:Saliva / Q000032:analysis* / Q000201:enzymology / Q000378:metabolism; D013395:Sucrose / Q000494:pharmacology; D013861:Thiocyanates / Q000032:analysis* / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000890:Anti-Infective Agents; D013861:Thiocyanates; D013395:Sucrose; C014607:hypothiocyanite ion; D010544:Peroxidases; D005947:Glucose