Long-term effects of surgical desalivation upon taste acuity, fluid intake, and taste buds in the rat.
Taste bud structure and taste preferences in intact and desalivated animals were evaluated to ascertain whether there was a structure-function relationship. Thirty-three totally desalivated rats and 30 sham-operated controls were tested between 95 and 110 d after surgery with a 48-hour two-bottle preference paradigm; they were then sacrificed, and the tongue epithelium and circumvallate papillae taste buds were examined histologically. Desalivated rats manifested significantly increased preferences for normally avoided solutions. Histological study of the dorsal tongue epithelium revealed increased keratosis. There were qualitative changes in the taste buds of the circumvallate papillae with some taste buds appearing shrunken and disorganized.
D000818:Animals; D004326:Drinking; D004327:Drinking Behavior; D006851:Hydrochloric Acid / Q000008:administration & dosage; D008297:Male; D011189:Potassium Chloride / Q000008:administration & dosage; D011803:Quinine / Q000008:administration & dosage; D051381:Rats; D012463:Saliva / Q000502:physiology*; D012469:Salivary Glands / Q000601:surgery; D013649:Taste / Q000502:physiology*; D013650:Taste Buds / Q000033:anatomy & histology / Q000502:physiology*; D014059:Tongue / Q000033:anatomy & histology; D014867:Water / Q000008:administration & dosage
D014867:Water; D011189:Potassium Chloride; D011803:Quinine; D006851:Hydrochloric Acid