A new strain (KW-1) of human chronic myeloid leukemia transplantable in lasat mice.
Heterotransplantation of cells from a patient with chronic myeloid leukemia into athymic nude mice and athymic asplenic lasat mice was performed. A serially transplantable tumor cell line (KW-1) was obtained in lasat mice, although the "take" rate was low. The tumor was composed of myeloid cells showing various degrees of differentiation and maturation. The cellular characteristics, the availability of lasat mice and the effect of whole body irradiation or pretreatment with anti-asialo GM1 on heterotransplantation of myeloid cells are described and discussed.
D000368:Aged; D000818:Animals; D002460:Cell Line; D005260:Female; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014183:Transplantation, Heterologous