Effect of centrally administered angiotensin on urine output in dogs.
The effect of angiotensin II was studied on urine volume, urine sodium and potassium sodium and potassium in mongrel dogs. Intracerebro-ventricular (icv) administration of angiotensin (100.0 micrograms) caused significant increase in urine volume without significant change in urine sodium and potassium level. Similar effect is also obtained in denervated dogs. The effect of intracerebroventricularly administered angiotensin is possibly due to the decrease in secretion of the Antidiuretic hormone (ADH) from posterior lobe of pituitary gland.
D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002818:Cordotomy; D004231:Diuresis / Q000187:drug effects*; D004285:Dogs; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D011188:Potassium / Q000652:urine; D013997:Time Factors; D014628:Vagotomy
D000804:Angiotensin II; D011188:Potassium