The role of metabolic factors in the interaction between opiates and homopyrimidazoles in the central nervous system.
Both the analgesic and the antitussive effects of morphine, codeine and azidomorphine, azidocodeine and azidoethylmorphine are potentiated in rats and cats by Probon, a minor analgesic, with a homopyrimidazole structure. The analgesic effect of opiates and their toxicity are more strongly influenced by the N-methylhomopyrimidazoles than their antitussive effect. In the potentiation between Probon and morphine derivatives metabolic interference may play a role at the N-demethylation level, occuring in the liver microsomes.
D000700:Analgesics; D000818:Animals; D000996:Antitussive Agents; D002490:Central Nervous System / Q000187:drug effects*; D003371:Cough / Q000517:prevention & control; D004347:Drug Interactions; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009020:Morphine / Q000378:metabolism; D009294:Narcotics / Q000494:pharmacology*; D011744:Pyrimidinones / Q000494:pharmacology*; D051381:Rats
D000700:Analgesics; D000996:Antitussive Agents; D009294:Narcotics; D011744:Pyrimidinones; D009020:Morphine; C100296:probon