Some epistatic two-locus models of disease. I. Relative risks and identity-by-descent distributions in affected sib pairs.
A two-locus disease model is presented in which a marker locus interacts epistatically with another unlinked trait to cause the disease. Such a model can lead to disease-marker associations and distortions in the sharing of marker types among affected family members. These effects are quantified. In the case of HLA-disease associations, this model is presented as an alternative to the "hitchhiking" theory of tight linkage leading to linkage disequilibrium.
D000483:Alleles; D002874:Chromosome Mapping; D004843:Epistasis, Genetic; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D012306:Risk
D005819:Genetic Markers; D006680:HLA Antigens