Aminoglycoside nephrotoxicity in dogs: dependence on drug, dose and regimen.
In female mongrel dogs nephrotoxicity of three aminoglycosides (gentamicin, tobramycin and netilmicin) was compared with relation to the cortical aminoglycoside concentration. A standard regimen of 45 mg/kg/day with constant intravenous infusion and once daily dosing of each aminoglycoside was used, and in subsequent dogs netilmicin daily dose was increased to an average of 73 mg/kg/day.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D009428:Netilmicin / Q000633:toxicity; D014031:Tobramycin / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D009428:Netilmicin; D014031:Tobramycin