Variant Philadelphia chromosome translocations in two patients with chronic myelogenous leukemia.
Two patients with chronic myelogenous leukemia and new variant Philadelphia chromosome translocations are reported. In one case, a 41-year-old male, a 10;22 translocation was found in all bone marrow cells examined. Furthermore, the Y chromosome was missing in 90% of the analyzed metaphase cells. In the second patient, a 22-year-old male, all the marrow cells contained a complex rearrangement involving chromosomes No. 2, 9 and 22.
D000328:Adult; D002872:Chromosome Deletion; D002900:Chromosomes, Human, 1-3 / Q000648:ultrastructure; D002904:Chromosomes, Human, 21-22 and Y / Q000648:ultrastructure*; D002906:Chromosomes, Human, 6-12 and X / Q000648:ultrastructure; D014644:Genetic Variation; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic; D014998:Y Chromosome / Q000648:ultrastructure