Reactivity of xenogeneic antihuman Ia antisera with the I-C subregion of the murine major histocompatibility complex. II. Biochemical studies.
The biochemical nature of the cross-reactive antigens on murine B cells, detected with xenogeneic antihuman Ia (H.Ia) sera, were examined. These antigens, coded for by the I-C subregion, were found to be carbohydrate in nature and probably exist as glycolipids on the cell surface. Furthermore, sugar inhibition studies demonstrated that the anti-H.Ia sera recognized identical monosaccharide residues on murine and human B cells.
D000818:Animals; D001667:Binding, Competitive; D002241:Carbohydrates / Q000494:pharmacology; D055598:Chemical Phenomena; D011232:Chemical Precipitation; D002621:Chemistry; D003429:Cross Reactions; D005815:Genetic Code; D006017:Glycolipids / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D008285:Major Histocompatibility Complex; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D011817:Rabbits
D002241:Carbohydrates; D006017:Glycolipids; D000949:Histocompatibility Antigens Class II; D007106:Immune Sera