title: Candidiasis of the liver and spleen in childhood.
abstract: Four children with acute leukemia and surgically documented candidiasis of the liver and/or spleen were examined with a combination of diagnostic imaging modalities including 99mTc-sulfur colloid and 67Ga-citrate scintigraphy, gray-scale ultrasound, and body computed tomography (CT). Abnormalities were detected in every individual examined. 99mTc-sulfur colloid scintigraphy revealed "cold" areas in the liver or spleen. With 67Ga scintigraphy, these areas were "cold" in some individuals and "hot" in others. Gray-scale ultrasound demonstrated hypoechoic lesions with central areas of increased echogenicity in hepatic involvement, and hypoechoic replacement of the spleen in splenic involvement. CT in one patient revealed low-density areas without contrast enhancement within the hepatic parenchyma and unsuspected renal involvement.
mesh_terms: D000293:Adolescent; D002177:Candidiasis / Q000150:complications / Q000175:diagnosis*; D002675:Child, Preschool; D005260:Female; D005710:Gallium Radioisotopes; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000150:complications*; D008100:Liver Abscess / Q000150:complications / Q000175:diagnosis*; D008297:Male; D013158:Splenic Diseases / Q000150:complications / Q000175:diagnosis*; D013455:Sulfur; D013667:Technetium; D013671:Technetium Tc 99m Sulfur Colloid; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D005710:Gallium Radioisotopes; D013671:Technetium Tc 99m Sulfur Colloid; D013455:Sulfur; D013667:Technetium