The major histocompatibility complex of rhesus monkeys. XIV. A family study of DR and other RhLA-linked cell membrane antigens.
The segregation of B-cell specific (Ia) determinants was studied in a large number of rhesus families. As expected, on the basis of results of a recent population study, the eight serologically defined DR antigens segregated as alleles of a single locus within RhLA. Two or three antigens not controlled by DR remained candidates for a second Ia series closely linked to DR. The 162 identifiable haplotypes provided interesting information regarding positive associations among antigens of two, three or even four sets of RhLA loci. Further, a new series of antigens closely linked to the RhLA-A locus could be postulated. Data obtained from 8 recombinant offspring permitted a better definition of the mapping position of all known loci of RhLA.
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics*; D002874:Chromosome Mapping; D005260:Female; D005796:Genes; D006649:Histocompatibility Antigens / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D008251:Macaca / Q000235:genetics*; D008253:Macaca mulatta / Q000235:genetics*; D008285:Major Histocompatibility Complex; D008297:Male
D000954:Antigens, Surface; D006649:Histocompatibility Antigens; D000949:Histocompatibility Antigens Class II