The effects of oral propranolol and indomethacin on the response to inhaled PGE2 in normal human subjects.
The effects of oral propranolol and oral indomethacin on the normal response to inhaled PGE2 has been studied in 8 human volunteers. Inhalation dose-response curves to PGE2 in doses from 10 to 400 micrograms were constructed on three separate occasions. Either 80 mg or propranolol, 50 mg of indomethacin or identical placebo tablets were ingested 1 1/2 hours before PGE2 inhalation in random order and double blind. Propranolol had no effect of PGE2 induced bronchodilatation. In most subjects indomethacin caused a small baseline bronchodilatation and enhancement of PGE2 effect. In 2 subjects, however, indomethacin caused almost complete suppression of PGE2 bronchodilatation.
D000284:Administration, Oral; D000328:Adult; D001980:Bronchi / Q000187:drug effects; D015232:Dinoprostone; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology*
D011458:Prostaglandins E; D011433:Propranolol; D015232:Dinoprostone; D007213:Indomethacin