In vivo incorporation of C14-1-acetate into liver and plasma lipids of postnatally overfed rats.
Postnatal overnutrition due to breeding of rats in small nests (4 pups per dam) leads to distinct metabolic changes in later life stages even in conditions of ad libitum feeding. At an age of 5 months rats from small nests differ from those of large nests (14 pups per dam) in a significant higher level of liver triglycerides and cholesterol esters, whereas changes in plasma lipids concern only the increased cholesterol ester fraction. The relative distribution of in vivo incorporated C14-1-acetate into liver lipids shows a higher moiety in the triglyceride fraction of animals from small nests but no changes of the relative distribution of activity among lipid fractions of plasma. These changes of lipid metabolism are discussed in relation to the development of an obese state of postnatally overfed animals.
D000085:Acetates / Q000378:metabolism*; D000828:Animal Population Groups / Q000378:metabolism*; D000818:Animals; D000833:Animals, Suckling / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D001068:Feeding and Eating Disorders / Q000378:metabolism*; D005260:Female; D006128:Growth; D006801:Humans; D006963:Hyperphagia / Q000378:metabolism*; D008055:Lipids / Q000096:biosynthesis* / Q000097:blood; D008098:Litter Size; D008099:Liver / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism
D000085:Acetates; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol