In vitro response to erythropoietin in erythroblastic transformation of chronic myelogenous leukemia.
A patient with Ph1-positive chronic myelogenous leukemia (CML) who entered an erythroblastic transformation prior to the development of a typical myeloblastic crisis is described. In vitro methylcellulose cultures obtained at the time of erythroblastic transformation revealed that the erythroid progenitors were responsive to erythropoietin. Thus, similar to the findings in polycythemia vera, the erythroid progenitors in this case of erythroblastic transformation of CML retained responsiveness to erythropoietin in vitro.
D001853:Bone Marrow / Q000473:pathology; D001854:Bone Marrow Cells; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D003470:Culture Media; D004900:Erythroblasts / Q000473:pathology*; D004912:Erythrocytes / Q000473:pathology*; D004921:Erythropoietin / Q000494:pharmacology*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood* / Q000473:pathology / Q000503:physiopathology; D008747:Methylcellulose; D008875:Middle Aged
D003470:Culture Media; D004921:Erythropoietin; D008747:Methylcellulose