The inhibition of vagal stimulated acid secretion by pirenzepine and cimetidine.
H2-receptor-antagonists inhibit pentagastrin-stimulated acid secretion for a longer period than basal secretion. Anticholinergic drugs and pirenzepine are less effective and act differently by reduction of volume. Acid concentration is reduced to 95% by cimetidine compared to 20% by atropine and pirenzepine. By increasing electrical vagal stimulation there is a decreasing effect of cimetidine. In contrast, atropine and pirenzepine inhibit vagally transmitted acid secretion by about 45%, even when vagally stimulated acid secretion amounts to more than 50% of the pentagastrin-stimulated secretion. These results support the hypothesis of histaminergic and cholinergic receptors in man.
D001285:Atropine / Q000494:pharmacology; D001570:Benzodiazepinones / Q000494:pharmacology*; D002927:Cimetidine / Q000494:pharmacology*; D004558:Electric Stimulation; D005744:Gastric Acid / Q000378:metabolism*; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D010418:Pentagastrin / Q000494:pharmacology; D010890:Pirenzepine; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*
D001570:Benzodiazepinones; D006146:Guanidines; D010890:Pirenzepine; D001285:Atropine; D002927:Cimetidine; D010418:Pentagastrin