Fv-4: gene controlling resistance to NB-tropic Friend murine leukemia virus. Distribution in wild mice, introduction into genetic background of BALB/c mice, and mapping of chromosomes.
A gene controlling resistance to NB-tropic Friend murine leukemia virus (F-MuLV) was studied in wild mice. Mice of various subspecies were crossed with inbred BALB/c mice, and their F1 hybrids were tested for resistance to F-MuLV. Some mice of Mus musculus molossinus (Japan), M. musculus castaneus (Taiwan and the Philippines), and M. musculus urbanus (Sri Lanka) appeared to have a dominant resistance gene. A partially congenic strain, BALB/c-Fv-4wr (C4W), was established by the introduction of the gene Fv-4wr from a M. musculus molossinus into the genetic background of BALB/c mice. [(C4W X DBA/2) X C57BL/6-Fvs] crosses revealed that Fv-4wr is located on chromosome 12 with the gene order of Fv-4w-Pre-1-lgh-1, apparently at the same site as the Fv-4. The resistance of C4W mice was indistinguishable from the Fv-4-controlled resistance of FRG mice.
D000818:Animals; D000831:Animals, Newborn; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005622:Friend murine leukemia virus / Q000235:genetics / Q000254:growth & development*; D005799:Genes, Dominant; D008040:Genetic Linkage; D007126:Immunoglobulin Allotypes; D007942:Leukemia, Experimental / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D009929:Organ Size; D011228:Prealbumin / Q000235:genetics; D013154:Spleen / Q000473:pathology
D007126:Immunoglobulin Allotypes; D011228:Prealbumin