Chromatin repeat length in somatic hybrids.
In order to study the mechanisms by which a characteristic repeat length is inherited in somatic cells, it was necessary to develop a method for determining repeat length with a precision of 1 to 2 base pairs. Hybrid clones between parental cell lines differing in repeat length by 6 base pairs were isolated. The four independent hybrid clones characterized had repeat lengths intermediate between those of the parental lines; however, it could be demonstrated that these repeat lengths are unique values and do not arise from a double distribution of the parental repeat lengths. It therefore is concluded that repeat length in somatic cells is determined by a common pool of diffusible substances.
D000818:Animals; D001665:Binding Sites; D002843:Chromatin / Q000648:ultrastructure*; D004247:DNA / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D006822:Hybrid Cells / Q000648:ultrastructure*; D007621:Karyotyping; D008836:Micrococcal Nuclease / Q000378:metabolism; D008970:Molecular Weight; D009707:Nucleosomes / Q000648:ultrastructure*; D051381:Rats
D002843:Chromatin; D006657:Histones; D009707:Nucleosomes; D004247:DNA; D008836:Micrococcal Nuclease