Preliminary evidence of dual-marked lymphocytes in thoracic duct lymph fluid.
Thoracic duct lymphocytes from patients receiving thoracic duct drainage as a pretransplant therapy were examined for cell surface markers. Patients followed over the drainage time period showed a variable but decreasing percentage of E-rosette-positive cells in the lymph fluid. A substantial percentage of these E-rosette-positive cells also had C3 receptors on their cell surface. Reactions of the whole lymphocytes with a heteroantisera to human B-lymphocyte antigens reflected the increasing proportion of B cells in the samples, but also indicated that a fraction of the T cells have Ia-like antigens on their surface marker characteristics. Significance of these cells with respect to graft survival is discussed.
D000818:Animals; D004322:Drainage; D000949:Histocompatibility Antigens Class II; D006801:Humans; D007958:Leukocyte Count; D008196:Lymph / Q000166:cytology*; D011817:Rabbits; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell; D011951:Receptors, Complement; D012397:Rosette Formation; D013897:Thoracic Duct / Q000166:cytology*
D000949:Histocompatibility Antigens Class II; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell; D011951:Receptors, Complement