The cardiotoxic antibiotic doxorubicin inhibits the Na+/Ca2+ exchange of dog heart sarcolemmal vesicles.
D000818:Animals; D002118:Calcium / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002122:Calcium Chloride / Q000378:metabolism; D002352:Carrier Proteins / Q000037:antagonists & inhibitors*; D004285:Dogs; D004317:Doxorubicin / Q000494:pharmacology*; D015251:Epirubicin; D006321:Heart / Q000187:drug effects; D007811:Lanthanum / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D012508:Sarcolemma / Q000187:drug effects / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism; D019831:Sodium-Calcium Exchanger; D013237:Stereoisomerism
D002352:Carrier Proteins; D019831:Sodium-Calcium Exchanger; D015251:Epirubicin; D007811:Lanthanum; D004317:Doxorubicin; D012964:Sodium; D002122:Calcium Chloride; D002118:Calcium