title: Prophylactic treatment of the central nervous system in acute lymphoblastic leukemia. CT findings in 45 children off therapy.
abstract: 45 children with ALL treated with intrathecal Methotrexate and radiation therapy, all in hematologic remission, have been examined with brain CT at intervals varying from 3 to 6 years after completion of CNS prophylaxis. Abnormalities were detected in 20% of the children; the main findings were: calcifications within the brain parenchyma in 3 patients; enlargement of the ventricular system and/or sulci in 8. The 3 patients with calcifications had seizures during or after treatment whereas those with dilatation of the ventricular system or sulci presented no neurological signs.
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000517:prevention & control* / Q000532:radiotherapy; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007278:Injections, Spinal; D007945:Leukemia, Lymphoid / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000628:therapy*; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects; D011878:Radiotherapy / Q000009:adverse effects; D014057:Tomography, X-Ray Computed
chemical_list: D008727:Methotrexate