title: 17 beta-Hydroxysteroid dehydrogenase in monkey endometrium during the menstrual cycle and at the time of implantation.
abstract: In order to furhter identify physiological similarities between 17 beta-hydroxysteroid dehydrogenase (HSD) in human and monkey endometrium and to evaluate the role of estradiol-17 beta (e2) oxidation to estrone (E1) during periimplantation events, 30 rhesus monkeys were studied at different intervals of the nonfertile menstrual cycle (days 8, 12, 15, 18 and 24). Also, five pregnant monkeys provided endometrial tissue on day 24 of the fertile menstrual cycle, near the expected time of implantation. HSD activity in endometrium was low at midfollicular phase (day 8), increased to maximal levels (8-fold) during the periovulatory span (days 12 and 15), and was intermediate in mid to late luteal phase (days 18 and 24) in non-fertile menstrual cycles. In the absence of ovulation, HSD was low throughout. These enzyme data fit with a pattern of daily peripheral serum levels of E2 and progesterone (P) and suggest that when the normal sequence of P follows elevated estrogens in late follicular phase, HSD activity is markedly enhanced in the early luteal phase. However, HSD activity in endometrium did not increase more in the fertile menstrual cycle, despite further elevations of serum P during rescue of the corpus luteum.
mesh_terms: D015067:17-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000818:Animals; D010064:Embryo Implantation; D004717:Endometrium / Q000201:enzymology*; D004958:Estradiol / Q000097:blood; D004970:Estrone / Q000378:metabolism; D004971:Estrus; D005260:Female; D008253:Macaca mulatta; D010060:Ovulation; D011247:Pregnancy; D011374:Progesterone / Q000097:blood
chemical_list: D004970:Estrone; D011374:Progesterone; D004958:Estradiol; D015067:17-Hydroxysteroid Dehydrogenases