title: Early toxic events in kidney of rat and man following administration of gentamicin at low doses.
abstract: Kidney cortex of rats and humans treated with low doses of Gentamicin have been examined both morphologically and biochemically. Specific alterations of the lysosomes (loss of activity of phospholipases; accumulation of phospholipid-like material) was detected as early as from 2-4 days of treatment. This finding is consistent with the concept that Gentamicin exerts its toxic action on kidney through lysosomal dysfunction.
mesh_terms: D000818:Animals; D005839:Gentamicins / Q000633:toxicity*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D007684:Kidney Tubules / Q000648:ultrastructure; D051381:Rats; D013045:Species Specificity; D013997:Time Factors
chemical_list: D005839:Gentamicins