Rapid quantitative determination of the effect of antiplaque agents and antisera on the growth, acid production, and adherence of Streptococcus mutans.
A rapid quantitative in vitro assay measured the effects of antiplaque agents and antiserum on growth and sucrose-mediated adherence of radio-labeled S. mutans 6715. Acid production was measured by change in pH. In this assay the primary effect of chlorhexidine and fluoride was bacteriostasis and inhibition of acid production, respectively; the primary effect of dextran, dextranase, and specific antiserum was inhibition of sucrose-mediated adherence.
D002327:Cariostatic Agents / Q000494:pharmacology*; D002710:Chlorhexidine / Q000494:pharmacology; D003773:Dental Plaque / Q000517:prevention & control; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D013295:Streptococcus mutans / Q000187:drug effects* / Q000254:growth & development / Q000276:immunology / Q000378:metabolism
D002327:Cariostatic Agents; D007106:Immune Sera; D002710:Chlorhexidine