Cytoprotection by PGE2, atropine, pirenzepine and vagotomy in rats.
Gastric cytoprotective effects of vagotomy, PGE2 and antimuscarinic compounds (pirenzepine, atropine) were studied in the rat. Both pharmacological and surgical treatment prevented the gastric damage induced by intragastric administration of acetylsalicylic acid plus hydrochloric acid. The mechanisms of action are discussed.
D000818:Animals; D001241:Aspirin / Q000633:toxicity; D001285:Atropine / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000494:pharmacology*; D015232:Dinoprostone; D005260:Female; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects*; D010890:Pirenzepine; D011458:Prostaglandins E / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D014628:Vagotomy
D001570:Benzodiazepinones; D011458:Prostaglandins E; D010890:Pirenzepine; D001285:Atropine; D015232:Dinoprostone; D001241:Aspirin