The effect of colchicine and vinblastine on the secretory activity of ameloblasts in the mouse lower incisor as revealed by autoradiography after injection of 35S-sodium sulphate.
The effect of colchicine (0.1 mg/100 g of body weight) and vinblastine (0.2 mg/100 g of body weight) on the secretory activity of ameloblasts in the mouse lower incisor was investigated using autoradiography, 10, 30, 120 min after a single injection of 25S-sodium sulphate. colchicine did not inhibit the synthesis of glycosaminoglycans but delayed the exocytosis of the labeled products into the enamel. Vinblastine inhibited both the biosynthetic activity of ameloblasts and the exocytosis, the latter in an higher degree than colchicine.
D000565:Ameloblasts / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D003078:Colchicine / Q000494:pharmacology*; D003743:Dental Enamel / Q000187:drug effects / Q000378:metabolism; D007180:Incisor; D008297:Male; D051379:Mice; D013462:Sulfur Radioisotopes; D013997:Time Factors; D014747:Vinblastine / Q000494:pharmacology*
D013462:Sulfur Radioisotopes; D014747:Vinblastine; D003078:Colchicine