title: Mutagenicity of Tris(2,3-dibromopropyl) phosphate in mammalian gonad and bone marrow tissue.
abstract: The mutagenic and clastogenic (chromosome breaking) effects of the flame retardant Tris(2,3-dibromopropyl) phosphate (Tris-BP) were investigated in two mammalian in vivo assays, the bone marrow micronucleus test and the abnormal sperm head assay. Two potency of Tris-BP was determined in the Salmonella-mammalian microsome assay. Tris-BP was mutagenic in all three assays, in both mammalian tests, nearly toxic doses were required in B6C3F mice for positive mutagenic and clastogenic results. In the micronucleus test, Tris-BP was a weak clastogen, whereas in the abnormal sperm head assay, Tris-BP was observed to be strongly mutagenic. The abnormal sperm head data might imply genetic damage to germ tissue. The data suggested a means for possibly monitoring Tris-BP exposure. Thus besides being a strong mutagen on bacterial systems, Tris-BP was also a weak clastogen as detected in bone marrow cells and was a mutagen to gonad tissue.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D006842:Hydrocarbons, Brominated / Q000494:pharmacology; D008297:Male; D051379:Mice; D009153:Mutagens; D010755:Organophosphates; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010336:Pathology; D012475:Salmonella / Q000187:drug effects / Q000235:genetics; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000648:ultrastructure
chemical_list: D006842:Hydrocarbons, Brominated; D009153:Mutagens; D010755:Organophosphates; D009943:Organophosphorus Compounds; C012085:tris(2,3-dibromopropyl)phosphate