Sister chromatid exchanges in Chinese hamster embryonic liver cells exposed transplacentally to bromodeoxyuridine (BrdU) and chemical mutagens.
5 mg cyclophosphamide, injected intraperitoneally to pregnant hamsters, increased the rate of sister chromatid exchanges (SCEs) in embryonic liver cells from 4.1 to 8.8 SCEs per cell. 20 mg methyl metanesulfonate induced 11.8 SCEs per embryonic cell.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001854:Bone Marrow Cells; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D006224:Cricetinae; D003412:Cricetulus; D003434:Crossing Over, Genetic; D005260:Female; D008099:Liver / Q000187:drug effects / Q000196:embryology / Q000648:ultrastructure*; D009153:Mutagens / Q000494:pharmacology*; D011247:Pregnancy; D012854:Sister Chromatid Exchange
D009153:Mutagens; D001973:Bromodeoxyuridine