title: Myeloproliferative and lymphoproliferative disorders in the same patient.
abstract: A 67-year-old man developed a Philadelphia-negative myeloproliferative disorder which initially manifested as marked thrombocytosis, followed two years later by marked leucocytosis. He subsequently developed an IgG lambda plasma cell dyscrasia together with a monoclonal proliferation of circulating lymphocytes with IgM kappa surface immunoglobulin. The lymphoid neoplasm was associated with a rapidly progressive and fatal course.
mesh_terms: D000368:Aged; D002904:Chromosomes, Human, 21-22 and Y / Q000032:analysis; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes; D008232:Lymphoproliferative Disorders / Q000150:complications* / Q000276:immunology; D008297:Male; D009196:Myeloproliferative Disorders / Q000150:complications* / Q000276:immunology; D010265:Paraproteinemias / Q000150:complications; D010950:Plasma Cells; D010976:Platelet Count; D011947:Receptors, Antigen, B-Cell / Q000276:immunology
chemical_list: D011947:Receptors, Antigen, B-Cell