Immunological unresponsiveness to HSA in chickens.
HSA injected into chickens after hatching induces suppression of anti-HSA antibody formation. Unresponsive chickens react by producing the anti-HSA antibodies earlier and more intensively after BSA challenge than after challenge with HSA. This effect cannot be ascribed to T cells, because they were found to play no substantial role in the unresponsiveness to HSA. Neither was active suppression, which could account for the depressed antibody production, detected. B cell inactivation seems to be the major mechanism involved in this unresponsiveness. However, some additional mechanism must prevent B cells of unresponsive chickens from producing anti-HSA antibodies after HSA challenge, although they are able to form them after immunization with BSA. We suggest that cellular interactions, either between B cells of different specificities or between B cells and macrophages, are responsible for this differential reactivity.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000008:administration & dosage; D002417:Cattle; D002645:Chickens / Q000276:immunology*; D003429:Cross Reactions; D006801:Humans; D007108:Immune Tolerance; D008954:Models, Biological; D012709:Serum Albumin / Q000276:immunology*; D012710:Serum Albumin, Bovine / Q000276:immunology
D000941:Antigens; D012709:Serum Albumin; D012710:Serum Albumin, Bovine