title: The role of metabolic factors in the interaction between opiates and homopyrimidazoles in the central nervous system.
abstract: Both the analgesic and the antitussive effects of morphine, codeine and azidomorphine, azidocodeine and azidoethylmorphine are potentiated in rats and cats by Probon, a minor analgesic, with a homopyrimidazole structure. The analgesic effect of opiates and their toxicity are more strongly influenced by the N-methylhomopyrimidazoles than their antitussive effect. In the potentiation between Probon and morphine derivatives metabolic interference may play a role at the N-demethylation level, occuring in the liver microsomes.
mesh_terms: D000700:Analgesics; D000818:Animals; D000996:Antitussive Agents; D002490:Central Nervous System / Q000187:drug effects*; D003371:Cough / Q000517:prevention & control; D004347:Drug Interactions; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009020:Morphine / Q000378:metabolism; D009294:Narcotics / Q000494:pharmacology*; D011744:Pyrimidinones / Q000494:pharmacology*; D051381:Rats
chemical_list: D000700:Analgesics; D000996:Antitussive Agents; D009294:Narcotics; D011744:Pyrimidinones; D009020:Morphine; C100296:probon