Localization and concentration of carcinoembryonic antigen (CEA) in gastrointestinal tumors: correlation with CEA levels in plasma.
In 50 patients with gastrointestinal carcinomas, the following tumor parameters were studied: the concentration and localization of carcinoembryonic antigen (CEA) in tissue, extension, invasion, infiltration, differentiation, and necrosis. CEA concentrations were measured in plasma samples of all patients. In 7 patients with gastric carcinomas, CEA concentrations in tissue were low. Generally, only single cells or cell groups were CEA-positive. Elevated CEA levels in plasma resulted mainly from distant metastases and not from the primary tumor. In 43 colorectal carcinomas, CEA concentrations in tissue varied between 1.5 and 472 microgram/g tissue. They were closely related to the degree of accumulation of CEA-positive necrotic material in the degree of accumulation of CEA-positive necrotic material in the neoplastic glands. In 35 patients with colorectal carcinomas without CEA producing distant metastases, preoperative CEA levels in plasma were normal when tumor necrosis and perineural invasion were absent and CEA concentrations in tissue were low. CEA levels in plasma were regularly elevated when the tumor showed considerable necrosis in the presence of high CEA concentrations in tissue.
D002272:Carcinoembryonic Antigen / Q000378:metabolism*; D002277:Carcinoma / Q000276:immunology*; D005770:Gastrointestinal Neoplasms / Q000097:blood / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D009336:Necrosis; D009362:Neoplasm Metastasis
D002272:Carcinoembryonic Antigen