Inhibition of induced L-ornithine decarboxylase stimulation and erythrodifferentiation in Friend erythroleukemia cells by 2',5'-isoadenylate trimer core.
Friend erythroleukemia cells were induced to differentiate by hexamethylene bisacetamide, dimethyl sulfoxide, and dimethylformamide. The effect of 2',5'-oligoadenosine (trimer core) on cell growth, on erythrodifferentiation, and on the level of L-ornithine decarboxylase was tested. The results indicated a dose response-inhibitory effect of the trimer core on erythrodifferentiation. The optimal dose of the trimer inhibited hexamethylene bisacetamide and dimethyl sulfoxide stimulation of L-ornithine decarboxylase activity, with no apparent effect on cell growth, resembling the effect of high doses of interferon on both erythrodifferentiation and L-ornithine decarboxylase reported previously.
D000081:Acetamides / Q000494:pharmacology; D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D003959:Diamines / Q000494:pharmacology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004126:Dimethylformamide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004915:Leukemia, Erythroblastic, Acute / Q000201:enzymology* / Q000473:pathology; D009374:Neoplasms, Experimental / Q000201:enzymology / Q000473:pathology; D009955:Ornithine Decarboxylase / Q000378:metabolism; D065108:Ornithine Decarboxylase Inhibitors
C031401:2',5'-oligoisoadenosine; D000081:Acetamides; D003959:Diamines; D065108:Ornithine Decarboxylase Inhibitors; D004126:Dimethylformamide; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase; D000241:Adenosine; C014026:hexamethylene bisacetamide; D004121:Dimethyl Sulfoxide