Terminal deoxynucleotidyl transferase activity in non-hematologic and hematologic neoplasms.
The presence of terminal deoxynucleotidyl transferase (TdT) has been determined in neoplastic cells from 50 patients with non-hematologic tumors as well as neoplastic cells from 85 patients with hematologic malignancies. The results indicate that TdT is not present in cells from non-hematologic tumors, Hodgkin's lymphoma, B cell lymphoproliferative disorders, peripheral T cell neoplasms, reactive lymphadenopathy, and acute non-lymphocytic leukemia. In contrast, TdT activity is present in non-T non-B cell acute lymphocytic leukemia, T cell acute lymphocytic leukemia, T cell lymphoblastic lymphoma and chronic granulocytic leukemia in blast crisis. It is concluded that the TdT assay is a measurement useful in the differential diagnosis of some hematologic malignancies.
D000208:Acute Disease; D002471:Cell Transformation, Neoplastic / Q000032:analysis; D004253:DNA Nucleotidylexotransferase / Q000032:analysis*; D004254:DNA Nucleotidyltransferases / Q000032:analysis*; D003937:Diagnosis, Differential; D006689:Hodgkin Disease / Q000175:diagnosis / Q000201:enzymology; D006801:Humans; D006965:Hyperplasia; D007938:Leukemia / Q000175:diagnosis / Q000201:enzymology*; D007945:Leukemia, Lymphoid / Q000175:diagnosis / Q000201:enzymology; D008198:Lymph Nodes / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000201:enzymology; D009369:Neoplasms / Q000175:diagnosis / Q000201:enzymology*
D004254:DNA Nucleotidyltransferases; D004253:DNA Nucleotidylexotransferase