Effects of prostaglandins on catecholamine metabolism of the central nervous system in rats.
The effects of 5 microgram prostaglandin (PG) A1, E1, E2 and F2 alpha injected intracerebroventricularly (i.c.v.) into conscious male rats were studied on the catecholamine contents of certain brain areas at different times after administration. PGE2 led to increased dopamine (DA) contents in the hypothalamus 10, 20 and 60 min, and in the septal region 20, 60 and 90 min following injection. PGE1 raised DA levels in the hypothalamus 20 min, and in the septum 20 and 60 min after i.c.v. administration. PGA1 and PGF2 alpha proved to be ineffective as regards the DA contents, while none of the PGs studied altered the noradrenaline (NA) contents of different brain areas. Disappearance of DA was significantly enhanced in the hypothalamus and in the septum, while NA disappearance rate was increased only in the hypothalamus after PGE1 and PGE2 i.c.v. injection in alpha-methyl-p-tyrosine treated rats.
D000527:Alprostadil; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D015232:Dinoprostone; D004298:Dopamine / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism*; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats; D012688:Septum Pellucidum / Q000378:metabolism; D019805:alpha-Methyltyrosine
D008781:Methyltyrosines; D011453:Prostaglandins; D011458:Prostaglandins E; D019805:alpha-Methyltyrosine; D000527:Alprostadil; D015232:Dinoprostone; D004298:Dopamine; D009638:Norepinephrine