title: Plasma fucosyltransferase as an indicator of imminent blastic crisis.
abstract: Plasma fucosyltransferase activity was evaluated as an indicator of an impending blastic transformation in 25 patients with chronic granulocytic leukemia (CGL). Fifteen age-and sex-matched controls were also studied. The level of enzyme activity was significantly higher in the plasma of patients with blastic transformation (1,630 +/- 570 units) compared with steady chronic granulocytic leukemia (509 +/- 110 units) and normal controls (354 +/- 57 units). In three patients with CGL, a rise in fucosyltransferase activity preceded any other clinical or laboratory parameter of blastic transformation by 16-20 weeks.
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D002478:Cells, Cultured; D005647:Fucosyltransferases / Q000097:blood*; D006602:Hexosyltransferases / Q000097:blood*; D006801:Humans; D007951:Leukemia, Myeloid / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D007962:Leukocytes / Q000201:enzymology; D008875:Middle Aged
chemical_list: D005647:Fucosyltransferases; D006602:Hexosyltransferases; D000469:Alkaline Phosphatase