title: Use of intrathecal and epidural morphine for pain relief in patients with malignant diseases: a preliminary report.
abstract: The results of a preliminary study involving the treatment of various malignant pain disorders by intrathecal (I.T.) or epidural (E) morphine sulfate (M.S.) injections in 18 patients are reported. Fourteen (78%) patients obtained satisfactory analgesic effects and 4 (22%) failed. The overall duration of pain relief was modest and ranged from 10 to 72 hours; the intrathecal route provided a slightly longer duration (median: 48 hours; range: 15-72 hours) of analgesia than that of the epidural route (median: 20 hours; range: 10-72 hours). Minor and transient complications occurred in 10 (55%) patients.
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000188:drug therapy*; D000368:Aged; D000698:Analgesia; D004824:Epidural Space; D005260:Female; D006261:Headache / Q000139:chemically induced; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D009325:Nausea / Q000139:chemically induced; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D012008:Recurrence; D013997:Time Factors; D014839:Vomiting / Q000139:chemically induced
chemical_list: D009020:Morphine