title: Organization of the methotrexate resistant mouse L5178YR dihydrofolate reductase gene and transformation of human HCT-8 cells by this gene.
mesh_terms: D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D003110:Colonic Neoplasms / Q000201:enzymology / Q000235:genetics*; D004351:Drug Resistance; D005784:Gene Amplification; D005809:Genes, Regulator; D005818:Genetic Engineering; D006801:Humans; D007940:Leukemia L5178 / Q000201:enzymology / Q000235:genetics; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics*; D014170:Transformation, Genetic
chemical_list: D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate