Differences in carcinogenicity after transplacental and postnatal administration of drugs and pesticides.
Comparative studies of the carcinogenic activity of procarbazine, methylphenylnitrosourea and ethylenethiourea after transplacental and postnatal administration showed that there were marked differences in frequency and spectrum of tumors induced. Possible causes of these differences are briefly discussed. It is suggested that transplacental experiments can provide special advantages in testing drugs and environmental chemicals for potential carcinogenicity and should be included in test programs.
D000818:Animals; D002273:Carcinogens / Q000378:metabolism; D005260:Female; D008431:Maternal-Fetal Exchange; D010575:Pesticides / Q000633:toxicity*; D011247:Pregnancy; D011344:Procarbazine / Q000633:toxicity; D051381:Rats; D014116:Toxicology; D015038:Zineb / Q000633:toxicity
D002273:Carcinogens; D010575:Pesticides; D011344:Procarbazine; D015038:Zineb