The crown-gall potato disk bioassay as a primary screen for compounds with antitumor activity.
A variety of samples consisting of purified compounds (of various origins) and ethanol extracts from plants were assayed for their activity on the growth and initiation of crown-gall tumors on potato disks. The results demonstrated a high correlation between the ability of these compounds to inhibit the initiation and growth of crown-gall tumors on potato disks and their corresponding activity on the mouse P388 leukemia protocol. Of the 21 compounds tested to date, there were two false-positives and one false-negative.
D000818:Animals; D000970:Antineoplastic Agents; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D051379:Mice; D010941:Plant Tumors; D012231:Rhizobium
D000970:Antineoplastic Agents