HLA-DR specificities among Japanese with several autoimmune diseases.
HLA-A, -B, -C, and -DR antigens were determined in order to study the association of HLA in Japanese patients with several autoimmune diseases, hypertrophic cardiomyopathy, and Hodgkin's disease. The frequency of HLA-DR4 was significantly increased in the patients with rheumatoid arthritis, juvenile-onset insulin-dependent diabetes mellitus (IDDM) and hypertrophic obstructive cardiomyopathy. In this study, no significant associations with A, B, or C specificities were observed except BW22 in IDDM. In contrast, the negative association with HLA-DR2 was observed in Hashimoto's thyroiditis, pemphigus vulgaris and hypertrophic non-obstructive cardiomyopathy.
D001172:Arthritis, Rheumatoid / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D002312:Cardiomyopathy, Hypertrophic / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology; D008040:Genetic Linkage; D006111:Graves Disease / Q000276:immunology; D006680:HLA Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D007564:Japan; D010392:Pemphigus / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000276:immunology
D006680:HLA Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II