Irreversible inactivation of mammalian delta 5-3 beta-hydroxysteroid dehydrogenases by 5,10-secosteroids. Enzymatic oxidation of allenic alcohols to the corresponding allenic ketones.
D015096:3-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors*; D007700:Kinetics; D011549:Pseudomonas / Q000201:enzymology; D012632:Secosteroids / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
C031957:4,5-allenic-3 beta-hydroxy-5,10-secosteroid; D012632:Secosteroids; D015096:3-Hydroxysteroid Dehydrogenases; C031954:delta(5)-3 beta-hydroxysteroid dehydrogenase