Lysosomal compartment of macrophages: extending the definition of GERL.
"Professional phagocytes" such as Kupffer cells show an extensive network of interconnected residual bodies with cytochemically demonstrable acid phosphatase [orthophosphoric monoester phosphohydrolase (acid optimum), EC 3.1.3.2]. In such cells and in other (hepatocytes, etc.) this compartment may be considered a part of GERL [a hydrolase-rich region of endoplasmic reticulum (ER) situated at the trans face of the Golgi apparatus from which various Lysosomes appear to arise].
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000648:ultrastructure; D006735:Horseradish Peroxidase; D007728:Kupffer Cells / Q000648:ultrastructure; D008247:Lysosomes / Q000502:physiology*; D008264:Macrophages / Q000648:ultrastructure*; D008854:Microscopy, Electron; D010587:Phagocytosis; D051381:Rats; D011924:Rats, Zucker
D002784:Cholesterol; D006735:Horseradish Peroxidase; D000135:Acid Phosphatase