Successful treatment of murine muscular dystrophy with the proteinase inhibitor leupeptin.
Mice with genetic muscular dystrophy were treated with intraperitoneal injections of the proteinase inhibitor leupeptin, beginning before the onset of weakness. A significant number of the treated animals failed to develop histological evidence of dystrophy, compared with controls. Leupeptin treatment prevented (or delayed) the onset of muscular dystrophy in this experiment.
D000818:Animals; D007976:Leupeptins / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D009137:Muscular Dystrophy, Animal / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D009842:Oligopeptides / Q000627:therapeutic use*; D013997:Time Factors
D007976:Leupeptins; D009842:Oligopeptides