title: [Effect of exogenous prostaglandin E2 on different stages in the formation of a humoral immune response].
abstract: The influence of exogenous prostaglandin E2 on different stages of the immune response to sheep red blood cells was studied in (CBA x C57BL) F1 mouse hybrids. It was shown that prostaglandin E2 in a dose of 10(-6) M given 72 h after antigen challenge increased the number of the plaque-forming cells. Prostaglandin E2 stimulated antibody formation on being injected to mice in doses 10(-6) M--5 . 10(-4) M 24 and 2 h prior to antigen challenge. Prostaglandin E2 enhanced endogenous colony formation when injected to mice 24 and 2 h prior to sublethal irradiation. It is suggested that prostaglandins regulate different stages of the immune response.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects; D003114:Colony-Forming Units Assay; D015232:Dinoprostone; D007114:Immunization; D007213:Indomethacin / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011458:Prostaglandins E / Q000276:immunology*
chemical_list: D011458:Prostaglandins E; D015232:Dinoprostone; D007213:Indomethacin
vernacular_title: Vliianie ékzogennogo prostaglandina E2 na razlichnye étapy formirovaniia gumoral'nogo immunnogo otveta.