Osseous changes and osteosacomas in mice continuously fed diets containing diethylstilbestrol or 17 beta-estradiol.
In a study on the long-term effects of dietary diethylstilbestrol or 17 beta-estradiol on C3H mice, estrogens induced a proliferation of osseous trabeculae and increased the incidence and hastened the development of osteofibrotic areas in the sterna. There were 6 osteosarcomas, 2 having metastases, in 1,242 mice fed dietary estrogens over 360 days, but none in 356 untreated controls. These tumors were reviewed along with 4 early sternal osteosarcomas selected from 17 osteosarcomas (only 1 in a control) found thus in two other ongoing comparable studies. In at least 1 case, and possibly in 2 other early cases, tumors were associated with areas of osteofibrosis, and 1 tumor was probably associated with proliferation of bony trabeculae in the medullary cavity.
D000818:Animals; D001859:Bone Neoplasms / Q000139:chemically induced*; D001842:Bone and Bones / Q000187:drug effects* / Q000473:pathology; D004032:Diet; D004054:Diethylstilbestrol / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D008175:Lung Neoplasms / Q000556:secondary; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000139:chemically induced; D012516:Osteosarcoma / Q000139:chemically induced*
D004958:Estradiol; D004054:Diethylstilbestrol