title: Prevention of cystic ovary induction in rabbits by aminoglutethimide.
abstract: Polycystic ovaries were induced in thyroidectomized rabbits by the administration of either 25 IU human chorionic gonadotrophin or 10 IU pregnant mare serum daily for a period of 20 days. Cystic ovaries in rabbits exhibited subnormal (P < 0.01) ovarian delta 5-3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) concentration and specific activity. Since weight of cystic ovaries was markedly elevated, however, total capacity for delta 4-3-ketosteroid production was enhanced. Concomitant administration of chorionic gonadotrophin and aminoglutethimide phosphate to thyroidectomized rabbits prevented the formation of cystic ovaries indicating that a steroid, or steroids formed beyond cholesterol in the biosynthesis pathway is necessary for the experimental induction of cystic ovaries in this laboratory animal.
mesh_terms: D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000616:Aminoglutethimide / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D006063:Chorionic Gonadotropin; D005260:Female; D006064:Gonadotropins, Equine; D010053:Ovary / Q000201:enzymology*; D011085:Polycystic Ovary Syndrome / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control*; D011817:Rabbits; D013965:Thyroidectomy
chemical_list: D006063:Chorionic Gonadotropin; D006064:Gonadotropins, Equine; D000616:Aminoglutethimide; D015096:3-Hydroxysteroid Dehydrogenases