Lysozyme (muramidase) and hemolytic complement (CH50U) in sera of beagle dogs and minipigs after longterm application of different preparations of estrogens and gestagens.
In studies for the chronic toxicity of estrogens and gestagens, lysozyme and hemolytic complement (CH50U) in sera of beagle dogs and minipigs were measured. Various doses of the sexsteroids were given: 0.01 mg, 0.1 mg and 1.0 mg/kg respectively. The influence of the steroids on the tested parameters after an application for 6 months was not significant, only in a single series with unphysiologically, high dosages of the preparations were some values changed significantly.
D000818:Animals; D003165:Complement System Proteins / Q000378:metabolism*; D004285:Dogs; D045166:Estradiol Congeners / Q000494:pharmacology*; D009113:Muramidase / Q000097:blood*; D045167:Progesterone Congeners / Q000494:pharmacology*; D013552:Swine
D045166:Estradiol Congeners; D045167:Progesterone Congeners; D003165:Complement System Proteins; D009113:Muramidase