Effect of autonomic agents on the secretion of N-acetyl-beta-glucosaminidase of mouse submaxillary gland.
The secretion of N-acetyl-beta-glucosaminidase of mouse submaxillary gland into saliva was stimulated by norepinephrine and phenylephrine but not by pilocarpine and isoproterenol. The stimulative effects of the alpha-adrenergic agents were inhibited by alpha-blockers, phentolamine, and phenoxybenzamine. These results suggest that the secretion of the enzyme is regulated through alpha-adrenergic receptors.
D000118:Acetylglucosaminidase / Q000378:metabolism*; D000818:Animals; D001337:Autonomic Agents / Q000494:pharmacology*; D006596:Hexosaminidases / Q000378:metabolism*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D010862:Pilocarpine / Q000494:pharmacology; D013363:Submandibular Gland / Q000201:enzymology*; D013566:Sympathomimetics / Q000494:pharmacology
D001337:Autonomic Agents; D013566:Sympathomimetics; D010862:Pilocarpine; D010656:Phenylephrine; D006596:Hexosaminidases; D000118:Acetylglucosaminidase; D007545:Isoproterenol; D009638:Norepinephrine