Neutrophilic leukemia.
A patient had chronic neutrophilic leukemia. The characteristic clinical features of this disease include long-standing neutrophilia in the absence of an underlying disease, marked granulocytic hyperplasia in the bone marrow, increased leukocyte alkaline phosphatase activity, and absence of Philadelphia chromosome in the marrow cells. The patient survived for six years but eventually died of acute erythroleukemia. Neutrophilic leukemia although rare, possesses characteristic features sufficient to be considered a distinct clinical and hematologic entity.
D000469:Alkaline Phosphatase / Q000097:blood; D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood* / Q000201:enzymology / Q000473:pathology; D007958:Leukocyte Count; D007962:Leukocytes / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology
D000469:Alkaline Phosphatase