Selenium inhibition of N-methyl-N-nitrosourea-induced mammary carcinogenesis in the rat.
The effect of supplemental dietary selenium on the postinitiation state of N-methyl-N-nitrosourea (MNU)-induced mammary carcinogenesis was investigated in noninbred female Sprague-Dawley rats. Mammary cancer was induced by a single iv injection of MNU. Supplemental selenium feeding was begun 7 days after carcinogen treatment. Feeding of selenium prolonged the latency of mammary cancer appearance and resulted in a reduction in the average number of cancers per rat. The results suggested an inhibitory effect of pharmacologic levels of dietary selenium on the postinitiation stage of mammary carcinogenesis.
D000230:Adenocarcinoma / Q000139:chemically induced; D000818:Animals; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D008770:Methylnitrosourea / Q000037:antagonists & inhibitors*; D009607:Nitrosourea Compounds / Q000037:antagonists & inhibitors*; D051381:Rats; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D009607:Nitrosourea Compounds; D008770:Methylnitrosourea; D012643:Selenium