title: Inhibition of experimental stress ulcer formation in rats.
abstract: We present an operation model in rats, which according to our opinion prevents duodenogastric reflux effectively. The duodenum is divided distally from the pylorus and a pyloro-jejunostomy performed combined with a Roux-en-Y anastomosis. Rats operated this way and submitted to restraint stress developed significantly less stress lesions than operated control under same conditions. However, operated rats submitted to the operation and offered a 5 mMol/l drinking solution of crude taurocholic acid during 20 days before submitted to stress had significantly more stress lesions than operated animals with tap water before restraint stress.
mesh_terms: D000818:Animals; D001655:Bile Reflux; D005769:Gastrointestinal Motility; D007583:Jejunum / Q000601:surgery*; D008297:Male; D011708:Pylorus / Q000601:surgery*; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications