Allelic exclusion of immunoglobulin expression is not caused by somatic segregation.
We have investigated the karyotype of immunoglobulin-producing cells in heterozygous animals. Using a karyotypic marker for one homolog of a chromosome carrying immunoglobulin genes, we established that immunoglobulin-producing cells are heterozygous with respect to this chromosome. Therefore, allelic exclusion of immunoglobulin expression cannot be caused by somatic chromosome segregation.
D000483:Alleles; D000818:Animals; D006579:Heterozygote; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D007072:Immunoglobulin D / Q000235:genetics*; D007075:Immunoglobulin M / Q000235:genetics*; D007621:Karyotyping; D051379:Mice; D011947:Receptors, Antigen, B-Cell / Q000235:genetics
D007126:Immunoglobulin Allotypes; D007072:Immunoglobulin D; D007075:Immunoglobulin M; D011947:Receptors, Antigen, B-Cell