Biliary carcinoma associated with methyldopa therapy.
In a retrospective study of 82 patients with biliary carcinoma a higher than expected prevalence of methyldopa therapy was found. Carcinogenesis by electrophile reactive metabolites of methyldopa is discussed.
D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000139:chemically induced*; D001653:Bile Ducts, Intrahepatic; D055598:Chemical Phenomena; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D002621:Chemistry; D003138:Common Bile Duct Neoplasms / Q000139:chemically induced*; D005260:Female; D006500:Hepatic Duct, Common; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D008750:Methyldopa / Q000009:adverse effects*; D008875:Middle Aged; D008962:Models, Theoretical; D012189:Retrospective Studies
D008750:Methyldopa