Immunogenicity of serum HLA antigens in allogeneic combinations.
Immunization of patients with chronic renal insufficiency with plasma from selected donors elicited lymphocytotoxic antibodies. Analysis of these antibodies with Fab2 blocking assays showed that they are directed to HLA-A,B and to Ia-like antigens. These results indicate that serum HLA antigens are immunogenic in allogeneic combinations.
D000818:Animals; D000961:Antilymphocyte Serum / Q000276:immunology; D001667:Binding, Competitive; D001803:Blood Transfusion; D003601:Cytotoxicity Tests, Immunologic; D006680:HLA Antigens / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D007518:Isoantibodies / Q000096:biosynthesis*; D007676:Kidney Failure, Chronic / Q000276:immunology / Q000628:therapy; D010949:Plasma; D011817:Rabbits; D012397:Rosette Formation
D000961:Antilymphocyte Serum; D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II; D007140:Immunoglobulin Fab Fragments; D007518:Isoantibodies