Translocation (5p; 17q) in blast crisis of chronic myeloid leukemia.
A new abnormality of chromosome 17, distinct from i(17q), was observed in bone marrow cells of two patients with CML during a blast crisis. The marker was identified as a translocation of the short arm of chromosome 5 onto the long arm of chromosome 17, i.e., t(5p; 17q). In one case, the marker was clearly dicentric. The clinical history of these two patients showed some similarities. A slightly different marker has previously been observed in a cell line derived from a solid tumor.
D000328:Adult; D001853:Bone Marrow / Q000648:ultrastructure; D002478:Cells, Cultured; D002902:Chromosomes, Human, 16-18; D002905:Chromosomes, Human, 4-5; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D014178:Translocation, Genetic