Behavioural tests in peri- and post-natal toxicity study in rats of trithiozine (Tresanil) [4-(3,4,5-trimethoxythiobenzoyl)-tetrahydro-1,4-oxazine].
During the biological research on trithiozine [4-(3,4,5-trimethoxythiobenzoyl)-tetrahydro-1,4-oxazine], a substance with gastric antisecretory action, a study on peri- and post-natal toxicity was conducted in rats, during which an attempt was made to set up a series of tests which would consist of the study of the behaviour of offspring in their first 21 days of life. To confirm the validity of these tests, a parallel peri- and post-natal toxicity study was carried out with two compounds phenobarbital and diazepam, known to be active on the CNS and likewise known to pass from plasma into milk. The three compounds in question were administered by the oral route to pregnant rats from the 15th day of pregnancy to the 20th day after delivery in the following dosages; trithiozine: 100-200-500 mg/kg/day, phenobarbital: 60-100 mg/kg/day, diazepam: 30-60 mg/kg/day. The offspring were submitted, between their 14th and 20th day of life to the cheminée test, traction test, righting reflex test and avoidance test. The cheminée and avoidance tests proved to be the most suitable for studying neonatal behaviour. The percentage of success in these two tests decreased in a statistically significant manner for the groups treated with phenobarbital and diazepam, while trithiozine did not produce any variations in neonatal behaviour.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology; D005260:Female; D005765:Gastrointestinal Agents / Q000633:toxicity*; D009025:Morpholines / Q000633:toxicity*; D010634:Phenobarbital / Q000494:pharmacology; D004856:Postural Balance / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects; D051381:Rats; D012018:Reflex / Q000187:drug effects
D005765:Gastrointestinal Agents; D009025:Morpholines; C012595:trithiozine; D003975:Diazepam; D010634:Phenobarbital