[Morphologico-genetic study of the enzymology of T4 phage recombination. II. Effect of antimutational T4 DNA-polymerase on correction-type recombination].
Effect of temperature antimutator L42 allele of gene 43 of T4 phage on the parameters of correction-type mechanism of genetic recombination have been studied under permissive conditions. The effect of L42 was found to be marker- as well as distance-dependent, and the pattern of these dependences shows that in the presence of antitumor DNA polymerase the distribution of the length of the repair region becomes more sharp and the mean length of the repair region becomes shorter. From this, it is concluded that T4 DNA polymerase is directly involved in the repair of mismatched region in recombinational intermediates, excising non-matched DNA strand and then filling the gap arisen.
D000483:Alleles; D004260:DNA Repair; D004259:DNA-Directed DNA Polymerase / Q000235:genetics*; D005819:Genetic Markers; D009154:Mutation; D011995:Recombination, Genetic; D013604:T-Phages / Q000201:enzymology / Q000235:genetics*; D013696:Temperature
D005819:Genetic Markers; D004259:DNA-Directed DNA Polymerase
Formal'no-geneticheskoe izuchenie énzimologii rekombinatsii u faga T4. Soobshchenie II. Vliianie antimutatornoĭ DNK-polimerazy T4 na rekombinatsiiu korrektsionnogo tipa.