title: Effects of prolonged administration of azathioprine on parotid glands of rats: an assessment by electron microscopy.
abstract: Electron microscopy demonstrated degranulation, vacuolation, development of cytolysosomes and focal areas of cellular necrosis in the acinar cells of the rat parotid glands following daily administration of 2 mg/Kg azathioprine. The changes were noted after seven days but stopped short of complete acinar and ductal cell destruction after about fifty-six days. Ductal cells were not so noticeably affected and rapid recovery in both cells followed cessation of the drug being complete in most within fourteen days.
mesh_terms: D000818:Animals; D001379:Azathioprine / Q000494:pharmacology*; D003593:Cytoplasm / Q000648:ultrastructure; D008854:Microscopy, Electron; D009940:Organoids / Q000648:ultrastructure; D010306:Parotid Gland / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D013997:Time Factors
chemical_list: D001379:Azathioprine