The effect of 5,5'-diphenylhydantoin on the metabolism of 17 beta-estradiol by rat oral mucosa.
Systemic pretreatment of rats with 5,5'-diphenylhydantoin (DPH) or its addition into an in vitro assay increases microsomal hydroxylation of 17 beta-estradiol. This increase depends on the concentration of DPH in the microsomal cell compartment.
D000818:Animals; D004958:Estradiol / Q000378:metabolism*; D005881:Gingiva / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009061:Mouth Mucosa / Q000187:drug effects / Q000378:metabolism*; D010672:Phenytoin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004958:Estradiol; D010672:Phenytoin