Long-term cytologic studies of copper-IUD users.
Cytologic evaluation was carried out in 198 women using copper T-200-mm intrauterine devices (IUDs) for periods ranging from four to eight years. Preinsertional cytology revealed one mild dysplasia; the lesion reverted to normal six months later and has remained normal after five years of copper T contraception. A total of 18 dysplasias (16 mild and 2 moderate) were found in post-IUD-insertion smears during follow-ups after one to eight years of IUD use. Regression of the lesion was noticed in 14 of the 18 within 6 to 12 months with the device in situ. Persistence of the lesion was found in one case and a waxing and waning pattern in two, necessitating removal of the device in all three. In the remaining case, the device was removed due to menopausal menstrual irregularity.
D000328:Adult; D005260:Female; D006801:Humans; D007435:Intrauterine Devices, Copper / Q000009:adverse effects*; D013997:Time Factors; D002578:Uterine Cervical Dysplasia / Q000209:etiology*; D002583:Uterine Cervical Neoplasms / Q000209:etiology*; D002575:Uterine Cervicitis / Q000209:etiology*; D014626:Vaginal Smears