title: Successful treatment of murine muscular dystrophy with the proteinase inhibitor leupeptin.
abstract: Mice with genetic muscular dystrophy were treated with intraperitoneal injections of the proteinase inhibitor leupeptin, beginning before the onset of weakness. A significant number of the treated animals failed to develop histological evidence of dystrophy, compared with controls. Leupeptin treatment prevented (or delayed) the onset of muscular dystrophy in this experiment.
mesh_terms: D000818:Animals; D007976:Leupeptins / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D009137:Muscular Dystrophy, Animal / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D009842:Oligopeptides / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D007976:Leupeptins; D009842:Oligopeptides