Osteosarcomas in BALB/c female mice.
Osteosarcomas were found in 16 of 24,192 (0.066%) BALB/c female mice, 14 were in 21,816 (0.064%) 2-acetylaminofluorene-treated mice, and two were in 2,376 (0.084%) untreated controls. The osteosarcomas were classified into osteoblastic, fibroblastic, and mixed types. Seven of the osteosarcomas metastasized to the lungs. The osteosarcomas in control and 2-acetylaminofluorene-treated mice showed little or no difference in the incidence, type, size, or site of origin, indicating that 2-acetylaminofluorene did not affect the development of osteosarcomas in BALB/c female mice.U
D015073:2-Acetylaminofluorene; D000818:Animals; D001859:Bone Neoplasms / Q000139:chemically induced / Q000145:classification / Q000473:pathology / Q000662:veterinary*; D005260:Female; D008175:Lung Neoplasms / Q000556:secondary / Q000662:veterinary; D051379:Mice; D008807:Mice, Inbred BALB C; D012516:Osteosarcoma / Q000139:chemically induced / Q000145:classification / Q000473:pathology / Q000662:veterinary*; D012376:Rodent Diseases / Q000473:pathology*; D012513:Sarcoma, Experimental / Q000139:chemically induced
D015073:2-Acetylaminofluorene