Evidence for a naturally occurring anti-spermine antibody in normal rabbit serum.
Normal rabbit serum contains an IgG-like component(s) that binds spermine as well as other polyamines. This molecule(s) has the same physicochemical properties as anti-spermine antibody obtained from rabbits immunized with spermine-thyroglobulin conjugates. However, the polyamines-binding IgG-like molecule(s), unlike anti-spermine antibody, is incapable either of precipitating a spermine-bovine serum albumin complex or of binding to a spermine-Sepharose column. These results suggest the existence of a naturally occurring anti-polyamine antibody that may have defective antibody functions.
D000818:Animals; D000918:Antibody Specificity; D002352:Carrier Proteins / Q000378:metabolism; D003429:Cross Reactions; D006241:Haptens; D011817:Rabbits; D013095:Spermidine / Q000276:immunology / Q000378:metabolism; D013096:Spermine / Q000276:immunology* / Q000378:metabolism
D002352:Carrier Proteins; D006241:Haptens; D013096:Spermine; D013095:Spermidine