Different molecular forms of human salivary lactoperoxidase.
The two different molecular forms shown to exist probably represent a monomer and an aggregate. The pI of lactoperoxidase (8.1) did not change during aggregation. The presence of substrate (SCN-) could cause some disaggregation suggesting that the mechanism of the dissociation is influenced by the substrate. Purified milk lactoperoxidase had a similar chromatographic pattern to salivary lactoperoxidase. Another peroxidase with pI 4.3 occurs in whole saliva but not in parotid secretions, and is possibly of leukocytic origin. However, its characteristics differ from those of neutrophil myeloperoxidase but resemble those of peroxidase of inflammatory exudate and gingival fluid.
D055598:Chemical Phenomena; D002621:Chemistry; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D006801:Humans; D007525:Isoelectric Focusing; D007784:Lactoperoxidase / Q000378:metabolism*; D008970:Molecular Weight; D010544:Peroxidases / Q000378:metabolism*; D012463:Saliva / Q000201:enzymology*
D007784:Lactoperoxidase; D010544:Peroxidases