[Dopamine secretion from the adrenal medulla during hypotension induced by hemorrhage in dogs (author's transl)].
The rate of secretion of dopamine (DA) was investigated along with those of norepinephrine (NE) and epinephrine (E) in the case of hemorrhagic hypotension. Blood samples were collected directly from the adrenal vein and DA, NE and E contents were measured using a gas-liquid chromatograph equipped with an electron-capture detector (GLC-ECD). Under the condition of hemorrhagic hypotension, the rates of secretion of DA, NE and E increased from 0.22, 3.4 and 13.7 ng/kg/min to 10.7, 89.7 and 361.4 ng/kg/min in 90 min, respectively. After reinfusion, the levels of DA, NE and E decreased. The concentration of DA in the femoral artery was 1.0 and 1.5 ng/ml at 70 and 90 min after hemorrhage. In spinal transected preparations, increases in the rates of DA, NE and E secretion did not occur during hemorrhagic hypotension. Thus, the rates of secretion of DA, NE and E varies with the hemodynamic changes, the secretion of DA from the adrenal gland is primarily controlled by the central nervous system, and the pattern of increase in level of DA differs from the patterns in the case of NE and E in hemorrhagic hypotension.
D000313:Adrenal Medulla / Q000378:metabolism*; D000818:Animals; D002818:Cordotomy; D004285:Dogs; D004298:Dopamine / Q000097:blood / Q000378:metabolism*; D004837:Epinephrine / Q000097:blood / Q000378:metabolism; D006470:Hemorrhage / Q000503:physiopathology*; D007022:Hypotension / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000097:blood / Q000378:metabolism
D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine