Fasting urinary sodium/creatinine in relation to calcium/creatinine and hydroxyproline/creatinine in a general population of women.
The relationships between urinary sodium excretion and bone loss and bone turnover were studied by looking at sodium/creatinine (Na/creat) values in relation to: (a) calcium/creatinine (Ca/creat); and (b) hydroxyproline/creatinine (HP/creat) values in fasting urines obtained from 574 women over 16 years of age participating in a health survey. Na/creat was positively correlated with Ca/creat (r=0.567, p less than 0.001) and with HP/creat (r=0.341, p less than 0.001). Both young and old women showed these relationships. However, postmenopausal women had higher Na/creat, Ca/creat and HP/creat values than premenopausal women. It seems that subjects with a high sodium excretion show a higher net bone loss and a higher bone turnover than subjects with low sodium excretion. The results suggest that salt intake should be considered when evaluating bone loss and bone turnover from fasting urinary Ca/creat and HP/creat measurements.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001862:Bone Resorption / Q000187:drug effects; D002118:Calcium / Q000652:urine*; D003404:Creatinine / Q000652:urine*; D004032:Diet; D005215:Fasting; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D008593:Menopause; D008875:Middle Aged; D012964:Sodium / Q000652:urine*; D012965:Sodium Chloride / Q000494:pharmacology*
D012965:Sodium Chloride; D012964:Sodium; D003404:Creatinine; D006909:Hydroxyproline; D002118:Calcium