The association of goitrous autoimmune thyroiditis with HLA-DR5.
We found HLA-DR5 to be present among 53% of 40 patients with goitrous autoimmune (Hashimoto's ) thyroiditis compared to 26% of 80 controls. No deviations from those expected in the incidences of HLA-A, B, C antigens were seen. In contrast HLA-DR3 was increased among 50 patients with atrophic thyroiditis (65%) compared to controls (24%). These findings stress the immunogenetic heterogeneity between the goitrous and atrophic varieties of thyroiditis.
D000917:Antibody Formation; D001327:Autoimmune Diseases / Q000150:complications* / Q000276:immunology; D008040:Genetic Linkage; D006042:Goiter / Q000150:complications* / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008861:Microsomes / Q000276:immunology; D013954:Thyroglobulin / Q000276:immunology; D013966:Thyroiditis / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000150:complications* / Q000276:immunology
D000949:Histocompatibility Antigens Class II; D013954:Thyroglobulin