title: Inhibition of dihydrofolate reductase by methotrexate: a new look at an old problem.
mesh_terms: D000818:Animals; D002384:Catalysis; D002478:Cells, Cultured; D003545:Cysteine; D005493:Folic Acid Antagonists; D006639:Histidine; D007700:Kinetics; D007939:Leukemia L1210 / Q000201:enzymology; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice; D009249:NADP / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D005493:Folic Acid Antagonists; D006639:Histidine; D009249:NADP; D003545:Cysteine; D008727:Methotrexate