title: Effect of peptide extracted from skeletal muscles of the fur seal on periodontal diseases.
abstract: It has been confirmed previously that a physiologically active peptide extracted from the skeletal muscles of fur seals exhibits excellent dermal absorption and has peripheral vasodilating properties. These properties were postulated to be beneficial to inflamed periodontal tissues. To test this, a dentifrice containing the peptide was prepared and utilized in a double-blind test. Significant improvement in the gingiva conditions was observed when a 0.1% or more concentration of peptide was used. As time progressed, distinct clinical improvement in redness, swelling, drainage, bleeding and pocket depth was noted. No significant side effects were noted although there were seen increased salivation and gingival blanching. It is believed, as a result of this and other studies, that the clinical efficacy of this peptide is due to its vasodilating action on the venules, thus reducing the internal pressure in the vascular beds.
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D010872:Caniformia; D003802:Dentifrices; D004311:Double-Blind Method; D005260:Female; D046069:Fur Seals; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000032:analysis / Q000378:metabolism*; D010455:Peptides / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D010510:Periodontal Diseases / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D003802:Dentifrices; D010455:Peptides