Mediastinal mass with acute leukemia. Myeloblastoma masquerading as lymphoblastic lymphoma.
Acute leukemia of myeloblastic or myelomonocytic type after non-Hodgkin's lymphoma is a recognized complication of radiotherapy or chemotherapy. However, a few reports suggest spontaneous development of, or coexistent, acute myeloblastic or myelomonocytic leukemia in patients with non-Hodgkin's lymphoma, unrelated to therapy. We studied a case initially interpreted as being lymphoblastic lymphoma with spontaneous acute leukemia, but subsequently shown by cytochemical and ultrastructural studies to be myeloblastoma. We reviewed the previously reported cases of non-Hodgkin's lymphoma with spontaneous myeloid leukemia in the light of our findings, and such cases may, in fact, represent myeloblastomas (granulocytic sarcomas) rather than non-Hodgkin's lymphoma.
D000368:Aged; D001706:Biopsy; D001854:Bone Marrow Cells; D003937:Diagnosis, Differential; D006801:Humans; D007945:Leukemia, Lymphoid / Q000473:pathology*; D007951:Leukemia, Myeloid / Q000473:pathology*; D015470:Leukemia, Myeloid, Acute / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008297:Male; D008479:Mediastinal Neoplasms / Q000473:pathology*