Cross-resistance of cultured murine leukemia vincristine-resistant P388 cells to vinblastine, vindesine, and bis (N-ethylidene vindesine) disulfide, disulfate.
Cultured P388 leukemia cells derived from vincristine (VCR)-resistant cell populations developed in vivo in (C57BL X DBA/2)F1 mice (P388/VCR) were cross-resistant to vinblastine (VLB), vindesine (VDS), and bis(N-ethylidene vindesine)disulfide, disulfate (bis-VDS). Cross-resistance was a function of concentration and time of exposure. Cultured P388/VCR cells were more sensitive to 6.1x10-5Mbis- VDS than to 6.1x10-5MVDS or to 6.1x10-5MVLB. Cultured P388 cells derived from VCR-sensitive P388 leukemia passaged in vivo (P388/0)were significantly more sensitive to VDS and bis-VDS than to VLB. This degree of difference in sensitivity was also a function of concentration and time of exposure.
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002470:Cell Survival; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D007941:Leukemia P388 / Q000473:pathology*; D007942:Leukemia, Experimental / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D011336:Probability; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000494:pharmacology; D014750:Vincristine / Q000494:pharmacology; D014751:Vindesine
D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine; D014747:Vinblastine; C034863:bis(N-ethylidene vindesine)disulfide; D014751:Vindesine