Histocompatibility determinants in Israeli Jewish patients with coeliac disease: population and family study.
The association between HLA and coeliac disease (CD) was studied in the Jewish population of Israel. A total of 112 patients were typed for HLA-A,B,C antigens, including 67 patients whose families were typed in order to deduce the genotypes. Forty-seven patients were typed for HLA-DR antigens. The HLA-A,B,C data show a pattern of association, which is similar to that found in European CD patients: HLA-B8 is increased, although to a lower degree; a suggestive, insignificant increase for Aw30, B13 and Cw6 and a decrease of Bw35 were noted. The DR antigens DR3 and DR7 are associated with CD in the Jewish population. An excess of DR3/DR7 heterozygotes was noted. The data from family and population studies support a model in which two different HLA-DR associated genes are interacting.
D002446:Celiac Disease / Q000235:genetics / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology; D005190:Family; D005192:Family Health; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D006238:Haploidy; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D007557:Israel; D007585:Jews; D008540:Meiosis; D010641:Phenotype; D011153:Population
D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II