Blood glucose of mother and fetus late pregnancy of rats with glycogen storage disorder.
The gsd/gsd rat is unable to mobilize liver glycogen due to an absence of phosphorylase b kinase activity. Unlike the normal rat, the maternal gsd/gsd rat cannot maintain its blood glucose concentration in late pregnancy, and values of 3.25 +/- 0.22 mM were found just before birth. The blood glucose of the gsd/gsd fetus falls to 1.76 +/- 0.09 mM at day 19 of gestation and does not rise appreciably again before birth. In contrast, normal fetal rats show a steady rise in blood glucose from hypoglycemic levels at day 19 to a value of 5.70 +/- 0.12 mM on the day of birth. These results indicate that the normal fetal rat contributes towards the regulation of its own glucose in late gestation by utilizing its liver glycogen stores.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005865:Gestational Age; D006003:Glycogen / Q000378:metabolism; D006008:Glycogen Storage Disease / Q000097:blood* / Q000150:complications; D008099:Liver / Q000196:embryology / Q000378:metabolism; D010764:Phosphorylase Kinase / Q000172:deficiency; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D051381:Rats
D001786:Blood Glucose; D006003:Glycogen; D010764:Phosphorylase Kinase