[Determination of primary prostaglandin (Pgs) and main metabolite of PgF2 alpha in blood plasma for diagnosis of primary dysmenorrhoea].
PGE2, PGF2 alpha, and 13,14-dihydro-15-keto-PGF2 alpha were determined in two-day intervals by means of radio-immuno-assay from plasma of the arm veins of eight women with primary dysmenorrhoea. No evidence could be produced to any rise in plasma concentration of primary prostaglandins and of the main metabolite of PGF2 alpha in the course of one full menstrual cycle. These findings are likely to show that in cases of dysmenorrhoea determination of prostaglandins in peripheral venous blood is unsuitable for verification of high endogenous formation from the endometrium.
D001711:Biotransformation; D015237:Dinoprost / Q000031:analogs & derivatives; D015232:Dinoprostone; D004412:Dysmenorrhea / Q000097:blood / Q000175:diagnosis*; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D011453:Prostaglandins / Q000097:blood*; D011458:Prostaglandins E / Q000097:blood; D011460:Prostaglandins F / Q000097:blood*; D011863:Radioimmunoassay
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; C008228:15-keto-13,14-dihydroprostaglandin F2alpha; D004958:Estradiol; D015237:Dinoprost; D015232:Dinoprostone
Zur Diagnostik der primären Dysmenorrhoe durch Bestimmung primärer Prostaglandine (PG's) und des PGF2 alpha-Hauptmetaboliten im Blutplasma.