title: Characterization of newly established human osteosarcoma cell line, LM-1.
abstract: The characteristics of Cell Line LM-1, established from a human osteosarcoma, have been studied extensively. The cell produced both bone-specific and placental-like alkaline phosphatases when treated with hydrocortisone 21-phosphate; they had specific membrane antigens tht reacted with sera from osteosarcoma patients. Injection of LM-1 cells into newborn hamsters treated with antilymphocyte serum produced nodular tumors. The characteristics of LM-1 suggest that this tumor cell line has unique features that may be useful in a variety of studies of human and animal osteosarcoma.
mesh_terms: D000469:Alkaline Phosphatase / Q000096:biosynthesis; D000818:Animals; D000951:Antigens, Neoplasm; D002455:Cell Division; D002460:Cell Line; D002467:Cell Nucleus / Q000648:ultrastructure; D006224:Cricetinae; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000494:pharmacology; D007621:Karyotyping; D009368:Neoplasm Transplantation; D012516:Osteosarcoma / Q000209:etiology / Q000276:immunology
chemical_list: D000951:Antigens, Neoplasm; C021650:hydrocortisone acetate; D000469:Alkaline Phosphatase; D006854:Hydrocortisone