[Behavior of PGE1 and PGE2 in the granulocytes of normal and leukemic subjects during phagocytosis in vitro].
The behaviour of phagocytosis and that of PGE1 and PGE2 in the circulating granulocytes of normal and leukaemic subjects was investigated by the comparison of latex particles and the PAP (peroxidase-antiperoxidase) immuno-enzymatic method respectively. Generally speaking, it was found that chronic myeloid leukaemia and acute myeloblastic leukaemia were accompanied by a marked reduction in phagocyting capacity, whereas this is apparently normal in CLL and ALL. PCE values, on the other hand, were well down in lymphatic leukaemia, AML and AMML, but not in CML, where high PGE (especially PGE2) was noted both basally and after phagocytosis. That the PGE take part in phagocytosis is shown by their redistribution in phagocyting cells, with elective accumulation in the membrane and around the engulfed material.
D000527:Alprostadil; D015232:Dinoprostone; D006098:Granulocytes / Q000032:analysis*; D006801:Humans; D007938:Leukemia / Q000097:blood*; D010587:Phagocytosis; D011458:Prostaglandins E / Q000097:blood*
D011458:Prostaglandins E; D000527:Alprostadil; D015232:Dinoprostone
Comportamento della PGE1 e della PGE2 nei granulociti di soggetti normali e leucemici durante la fagocitosi in vitro.