Megakaryoblastic transformation of chronic myelogenous leukemia.
A 52-year-old man with Ph1-positive chronic myelogenous leukemia (CML) developed a blastic transformation in which the predominant cell type micromegakaryocytes. He did not respond to treatment. A review of the 15 previously reported cases of patients with circulating megakaryocyte abnormalities in association with either CML or a Ph1 chromosome positive myeloproliferative disorder suggests a female predominance rather than the usual male predominance of CML. Survival of the six patients reported as megakaryoblastic transformation of CML as well as this patient was poor.
D002904:Chromosomes, Human, 21-22 and Y; D003599:Cytoskeleton / Q000648:ultrastructure; D006801:Humans; D007425:Intracellular Membranes / Q000648:ultrastructure; D007951:Leukemia, Myeloid / Q000097:blood / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008533:Megakaryocytes / Q000473:pathology* / Q000648:ultrastructure; D008875:Middle Aged; D012737:Sex Factors; D013920:Thrombocythemia, Essential / Q000473:pathology