title: Studies on osteoporosis IV. Effect of benzo[b]thiophene-2- and dibenzothiophene-4-carboxylic acid on heparin accelerated osteoporosis.
abstract: Total skeletal calcium was determined in female mice with the aid of whole body neutron activation analysis. Three months treatment with heaprin produced significant osteoporosis in C3-H/St(Ha) mice but not in C57/BL6(J) mice. This was more pronounced in the younger (5-8 months) than in the older (15-18 months) animals. Two 2-thiophene carboxylic acid derivatives showed significant osteoporosis preventive activity.
mesh_terms: D000818:Animals; D005260:Female; D006493:Heparin; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D010024:Osteoporosis / Q000139:chemically induced / Q000188:drug therapy*; D013876:Thiophenes / Q000627:therapeutic use*
chemical_list: D013876:Thiophenes; C026164:dibenzothiophene-4-carboxylic acid; D006493:Heparin; C026163:benzo(b)thiophene-2-carboxylic acid