title: Infection with Bacteroides fragilis: pathogenesis and immunoprophylaxis in an animal model.
abstract: Organisms of the genus Bacterioides represent the major group of obligate anaerobes involved in human infections. Bacteroides usually cause either bacteremia or localized abscesses. Of the numerous species of Bacteroides, Bacteroides fragilis is the single most frequent clinical isolate. B. fragilis and Bacteroides melaninogenicus have chemically incomplete lipopolysaccharides as compared with the lipopolysaccharides (endotoxins) of aerobic bacteria, and the lipopolysaccharides of Bacteroides lack of biologic potency characteristic of endotoxin. This inactivity may account for the very infrequent occurrence of disseminated intravascular coagulation or purpura that can accompany sepsis due to these organisms. Furthermore, strains of B. fragilis have an immunologically common capsular polysaccharide. In an animal model of intraabdominal sepsis, the encapsulated strains caused abscesses when given without other organisms. But abscess formation from unencapsulated strains of Bacteroides generally required the administration of a synergistic aerobe. The abscesses caused by encapsulated strains were shown to be directly attributable to the capsular polysaccharide, which is an important virulence factor of this organism. Antibody against the capsular antigen is protective against bacteremia due to B. fragilis, but T cell mediated immunity is protective against experimental intraabdominal abscesses.
mesh_terms: D000818:Animals; D001442:Bacteroides Infections / Q000382:microbiology*; D001441:Bacteroides fragilis / Q000276:immunology / Q000472:pathogenicity* / Q000648:ultrastructure; D002462:Cell Membrane / Q000032:analysis; D006801:Humans; D007114:Immunization; D008954:Models, Biological; D011135:Polysaccharides, Bacterial; D051381:Rats; D018805:Sepsis / Q000382:microbiology*; D014774:Virulence
chemical_list: D011135:Polysaccharides, Bacterial