Giant-cell reaction in the small tubular bones. A light- and electron-microscopic study.
Light- and electron-microscopic investigations were performed in a case of cystic soap-bubble-like expansion of the shaft region of the second metatarsal bone. Morphologically, strongly cellular tissue with a closely packed net of osteoid trabeculae containing osteoblasts and a whorl-shaped spindle cell stroma with fibroblasts, fibrocytes, and irregularly scattered multinucleated giant cells of the osteoclast type were observed. After clinical and morphological exclusion of osteosarcoma, enchondroma, non-ossifying fibroma, osteoblastoma, osteoclastoma, and bone cysts the final diagnosis was giant-cell reaction of small tubular bone with unusual marked osteoid formation. As recurrences are possible, block resection appears more appropriate than curettage.
D000293:Adolescent; D001845:Bone Cysts / Q000473:pathology; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D005870:Giant Cell Tumors / Q000473:pathology; D006801:Humans; D008297:Male; D008684:Metatarsus / Q000473:pathology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D010017:Osteoma, Osteoid / Q000473:pathology; D012516:Osteosarcoma / Q000473:pathology