Lectin derivatives of methotrexate and chlorambucil as chemotherapeutic agents.
Methotrexate and chlorambucil, each covalently linked to either abrus agglutinin, abrin, ricinus agglutinin, ricin, or concanavalin A, were prepared. A single dose of the derivative injected ip into sarcoma 180-bearing noninbred N:NIH(S) white mice resulted in prolongation of the survival time and was more effective than an equivalent dose of free drug and lectin. Drug-lectin also showed a higher inhibitory effect on the DNA biosynthesis of the tumor cell than did an equivalent dose of the free drug and lectin.
D000036:Abrin / Q000627:therapeutic use; D000818:Animals; D002699:Chlorambucil / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003208:Concanavalin A / Q000627:therapeutic use; D004273:DNA, Neoplasm / Q000096:biosynthesis; D037102:Lectins / Q000627:therapeutic use*; D008297:Male; D008727:Methotrexate / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051379:Mice; D012276:Ricin / Q000627:therapeutic use; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000378:metabolism
D004273:DNA, Neoplasm; D037102:Lectins; D003208:Concanavalin A; D000036:Abrin; D002699:Chlorambucil; D012276:Ricin; D008727:Methotrexate