Further evidence for postganglionic actions of prostaglandin F2 alpha and histamine in the submandibular gland of the dog.
To test the possibility that prostaglandin F2 alpha and histamine might produce salivary and vasodilator responses by stimulation of preganglionic parasympathetic nerve fibers in the submandibular gland the responses to the two substances of chronically decentralized glands were compared with those of acutely decentralized ones in anesthetized dogs. No significant differences in responses to either prostaglandin F2 alpha or histamine were noted between chronically decentralized glands and acutely decentralized ones. Thus, it was concluded that prostaglandin F2 alpha and histamine only stimulate parasympathetic postganglionic neurons within the gland and neither of the responses is related to non-cholinergic ganglionic transmission.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D015237:Dinoprost; D004285:Dogs; D005726:Ganglia, Parasympathetic / Q000502:physiology*; D006632:Histamine / Q000494:pharmacology*; D009538:Nicotine / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology*; D013363:Submandibular Gland / Q000187:drug effects / Q000294:innervation*; D014664:Vasodilation / Q000187:drug effects
D011460:Prostaglandins F; D009538:Nicotine; D006632:Histamine; D015237:Dinoprost; D000109:Acetylcholine