Hormone cytostatic agents.
Antitumour agents in which various steroids were used as carriers for different cytostatic groups have been synthesized at the Research Laboratories of AB Leo, Helsingborg, Sweden. The chemical and pharmacological properties of two of these agents, estramustine phosphate and prednimustine, are reported. These agents have been shown to have good effects in the treatment of advanced hormone-resistant cancer.
D000818:Animals; D000970:Antineoplastic Agents; D004351:Drug Resistance; D004961:Estramustine / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology; D006728:Hormones / Q000494:pharmacology*; D008297:Male; D011238:Prednimustine / Q000494:pharmacology; D051381:Rats
D000970:Antineoplastic Agents; D005938:Glucocorticoids; D006728:Hormones; D004961:Estramustine; D011238:Prednimustine