title: Molecular structure of a double helix that has non-Watson-Crick type base pairing formed by 2-substituted poly(A) and poly(U).
abstract: X-ray fiber diffraction studies of duplexes formed by 2-substituted poly(A) and poly(U) provide evidence for the existence of a double helical structure of poly(A).poly(U) held together by Hoogsteen-type base pairing with parallel chain polarity.
mesh_terms: D005583:Fourier Analysis; D006860:Hydrogen Bonding; D009690:Nucleic Acid Conformation; D011061:Poly A; D011063:Poly A-U; D013329:Structure-Activity Relationship; D013873:Thionucleotides; D014961:X-Ray Diffraction
chemical_list: D013873:Thionucleotides; D011063:Poly A-U; D011061:Poly A; C020476:poly(2'-methylthioadenylic acid)