Acrylonitrile metabolism in the rat.
Acrylonitrile (AN) is metabolized by an oxidative pathway via glycidonitrile and glycolaldehyde cyanohydrin to cyanide (CN-), which is transformed to thiocyanate. The major route of AN metabolism (more than 2/3), however, proceeds via cyanoethylation of glutathione, to N-acetyl-S-(2-cyanoethyl)cysteine (AN-mercapturic acid) as a final product.
D000181:Acrylonitrile / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D003486:Cyanides / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D009570:Nitriles / Q000378:metabolism*; D051381:Rats
D003486:Cyanides; D009570:Nitriles; D000181:Acrylonitrile