Bone marrow origin of Ia-positive cells in the medulla rat thymus.
Irradiated rats were reconstituted with bone marrow from F1 hybrids. Ia antigen of donor-bone marrow origin was detected by an immunoperoxidase technique on cryostat sections and found predominantly in the medulla of rat thymus 2 wk after reconstitution. These Ia-bearing cells increased in number with time after reconstitution, but the Ia on the cortical epithelial cells remained of host origin. The nature of the bone marrow-derived cells and their implication for major histocompatibility complex restriction are discussed.
D000818:Animals; D001853:Bone Marrow / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D008285:Major Histocompatibility Complex; D051379:Mice; D011828:Radiation Chimera; D051381:Rats; D013950:Thymus Gland / Q000166:cytology* / Q000276:immunology
D000949:Histocompatibility Antigens Class II