Reconstruction of the mandible by means of a similar allogenic lyophilized mandibular segment. I. Morphological and immunological studies in monkeys.
Subperiosteal resection of the entire ramus including the condyle followed by immediate reconstruction using a similar allogenic lyophilized mandibular segment was performed in 5 adult monkeys (Macaca irus). One further animal served as a control for the operative technique and another provided the initial 2 rami for implantation into the first of the 5 experimental animals, while an additional animal was used to supply fresh bone specimens for immunological studies. Sequential polychrome labelling with oxytetracycline, DCAF and haematoporphyrin was used, and X-rays were taken at regular intervals; the reconstructed condyles proved to be radiographically and macroscopically indistinguishable from those of the control side. All reconstructed bone transplants took. Immunological investigations (leukocyte-migration-inhibition tests) revealed that lyophilized allogenic bone grafts exhibit reduced antigenicity.
D000818:Animals; D001861:Bone Regeneration; D002464:Cell Migration Inhibition; D005612:Freeze Drying; D007962:Leukocytes / Q000276:immunology; D008251:Macaca; D008334:Mandible / Q000276:immunology / Q000502:physiology / Q000637:transplantation*; D008335:Mandibular Condyle / Q000502:physiology; D010027:Osteotomy / Q000379:methods; D014184:Transplantation, Homologous