Chlorpropamide-alcohol flushing and blood kinins.
In a pilot study six patients with noninsulin dependent diabetes, three positive and three negative to chlorpropamide-alcohol flushing (CPAF), were tested. The patients were tested both without and with chlorpropamide premedication. Blood kinin concentrations were determined before and after ingestion of small quantities of alcohol. No rise in blood kinin concentrations were found during the flush suggesting that kinins do not play a major part in chlorpropamide-alcohol flushing.
D000428:Alcohol Drinking; D002747:Chlorpropamide / Q000009:adverse effects*; D003920:Diabetes Mellitus / Q000097:blood* / Q000188:drug therapy; D005148:Facial Dermatoses / Q000139:chemically induced*; D006801:Humans; D007705:Kinins / Q000097:blood*; D010865:Pilot Projects; D011458:Prostaglandins E / Q000096:biosynthesis
D007705:Kinins; D011458:Prostaglandins E; D002747:Chlorpropamide