title: Absence of common ALL antigen on normal bipotent myeloid, erythroid, and granulocyte progenitors.
abstract: The presence of the common acute lymphoblastic leukemia antigen (CALLA) on leukemic cells from the great majority of patients with non-T cell acute lymphoblastic leukemia and chronic myelogenous leukemia in blast crisis suggests that CALLA could be differentiation antigen expressed by normal lymphoid and myeloid stem cells. Treatment with a murine monoclonal anti-CALLA antibody and complement lysed CALLA-positive leukemic cells quantitatively, whereas similar treatment of nucleated cells from peripheral blood and bone marrow failed to affect the expression, in semisolid culture, of CFU-G/E, BFU-E, CFU-E, or CFU-C. These data suggest that CALLA is not a normal differentiation antigen of the myeloid bipotent cell or its committed progenitors.
mesh_terms: D000208:Acute Disease; D000951:Antigens, Neoplasm; D001777:Blood Coagulation; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D003602:Cytotoxicity, Immunologic; D004912:Erythrocytes / Q000166:cytology*; D006098:Granulocytes / Q000166:cytology; D006410:Hematopoiesis; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology*; D008747:Methylcellulose / Q000378:metabolism
chemical_list: D000951:Antigens, Neoplasm; D008747:Methylcellulose