The pharmacokinetics and acceptability of benoxaprofen following rectal administration.
The bioavailability of a single 300 mg dose of benoxaprofen was compared after rectal and oral administration in 5 subjects. The total absorption rectally from a suppository was 83% of that achieved orally from a capsule. Six further subjects took a 300 mg benoxaprofen suppository twice daily for 12 d. Steady state plasma levels (mean level 94 microgram/ml) were reached at about 120 h, while the elimination half-life for benoxaprofen was approximately 38 h in this study. The suppositories were well tolerated. The plasma levels obtained compared very favorably with theoretically expected levels and levels obtained after comparable oral doses.
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000378:metabolism; D001583:Benzoxazoles / Q000008:administration & dosage* / Q000009:adverse effects / Q000378:metabolism; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D010342:Patient Acceptance of Health Care; D011422:Propionates / Q000008:administration & dosage* / Q000009:adverse effects / Q000378:metabolism; D013488:Suppositories; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D001583:Benzoxazoles; D011422:Propionates; D013488:Suppositories; C011677:benoxaprofen