beta-Cyclodextrin: promoting effect on the development of renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine.
Injection (sc) of beta-cyclodextrin (beta-C) increased the number and size of renal tubular cell tumors in inbred Wistar (W) rats treated with 1,000 ppm of N-ethyl-N-hydroxyethylnitrosamine (EHEN). The incidence of renal tumors at the end of the 32-week experiment was 50% in rats treated with 1,000 ppm EHEN for 2 weeks and 100% in rats treated with 1,000 ppm EHEN for 2 weeks and then given daily sc injections of beta-C for 1 week. The incidence of renal tumors more than 3 mm in diameter was 70% in rats treated with 1,000 ppm EHEN before beta-C but 0% in rats treated with EHEN alone. In addition, beta-C promoted the development of renal tumors in rats treated with 500 ppm EHEN, which is a subthreshold dose for renal tubular cell tumorigenesis. These results show that beta-C promotes EHEN-induced renal tubular cell tumorigenesis.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D003043:Cocarcinogenesis; D003505:Cyclodextrins / Q000633:toxicity*; D003912:Dextrins / Q000633:toxicity*; D004032:Diet; D004052:Diethylnitrosamine / Q000031:analogs & derivatives / Q000633:toxicity*; D007672:Kidney Cortex / Q000473:pathology; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000473:pathology; D007684:Kidney Tubules / Q000187:drug effects; D008297:Male; D009602:Nitrosamines / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013213:Starch / Q000633:toxicity*; D047392:beta-Cyclodextrins
D002273:Carcinogens; D003505:Cyclodextrins; D003912:Dextrins; D009602:Nitrosamines; D047392:beta-Cyclodextrins; C023845:N-ethyl-N-hydroxyethylnitrosamine; D004052:Diethylnitrosamine; D013213:Starch; C031215:betadex