Acute erythroleukaemia with L3 morphology and the 14q+ chromosome.
L3 morphology according to the FAB classification and the 14q+ chromosome are usually ascribed to the Burkitt type of leukaemia or lymphoma with a B or pre-B cell phenotype. We report here a case of adult acute leukaemia with Burkitt morphology and the 14q+, which did not express lymphoid markers. Instead, the leukaemia was shown to be an acute erythroleukaemia. The erythrocyte marker glycophorin A was present on the surface of the leukemic blasts as shown by immunofluorescence and immunoprecipitation from membrane lysates of surface labeled cells with antiglycophorin A antiserum. Spectrin and fetal hemoglobin appeared after cultivation of the blasts in the presence of sodium butyrate. The present case shows that a short term cultivation is sometimes useful for further characterization of the commitment of acute leukaemias.
D000208:Acute Disease; D000368:Aged; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002874:Chromosome Mapping; D002901:Chromosomes, Human, 13-15; D004900:Erythroblasts / Q000145:classification / Q000166:cytology; D005260:Female; D006021:Glycophorins / Q000032:analysis / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D004915:Leukemia, Erythroblastic, Acute / Q000097:blood / Q000145:classification / Q000235:genetics*; D007945:Leukemia, Lymphoid / Q000145:classification / Q000235:genetics / Q000276:immunology; D011817:Rabbits
D006021:Glycophorins