Inhibition of positive chronotropic effects of PGE2 by alinidine.
Alinidine has been investigated for a possible mode of action in guinea-pig atria. Alinidine up to 10(-6) M did not change the spontaneous rate but inhibited concentration-dependently the positive chronotropic effects of PGE2 in a non-competitive way. The chronotropic effects of adrenaline were not influenced by 10(-6) M alinidine. These results provide evidence for a PGE2 antagonistic action which could be involved in the mechanism of the cardiac slowing effects of alinidine in guinea-pigs.
D000818:Animals; D003000:Clonidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D015232:Dinoprostone; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D011458:Prostaglandins E / Q000037:antagonists & inhibitors*
D011458:Prostaglandins E; C022192:alinidine; D015232:Dinoprostone; D003000:Clonidine; D004837:Epinephrine