Ultrastructural changes of secreting rat-incisor ameloblasts following administration of vincristine and vinblastine.
Ultrastructural changes of secreting rat-incisor ameloblasts after administration of vincristine and vinblastine were observed. Polarity of nuclei and cytoplasmic organellae was remarkably disturbed; consequently, the regular secreting orientation of cellular products was altered greatly, leading to heterotopic deposition of large amounts of enamel matrix.
D000565:Ameloblasts / Q000187:drug effects / Q000648:ultrastructure*; D000818:Animals; D006056:Golgi Apparatus / Q000648:ultrastructure; D007180:Incisor / Q000166:cytology; D008297:Male; D008854:Microscopy, Electron; D009940:Organoids / Q000187:drug effects / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014747:Vinblastine / Q000494:pharmacology*; D014750:Vincristine / Q000494:pharmacology*
D014750:Vincristine; D014747:Vinblastine