Effects of 2-deoxy D-glucose and other sugar analogues on acid production from sugars by human dental plaque bacteria.
Solutions (10-25 microM) of D-glucose, N-acetyl-D-glucosamine, D-fructose, sucrose, maltose, lactose and maltotriose were readily metabolised to acid (140-250 mumol H+ wet g-1h-1) by anaerobic suspensions of fresh plaque at pH 7.5. D-Mannose, D-galactose, D-glucosamine and trehalose were broken down more slowly (35-115 mumol H+ wet g-1h-1). Inhibition of this acid production occurred on adding excess amounts of 2-deoxy-D-glucose or 5-thio-D-glucose. Similarly, excess amounts of cellobiose specifically inhibited acid liberation from lactose. No acid production was detected from a number of other sugars and sugar derivatives, some of which may be useful sucrose substitutes.
D000328:Adult; D001419:Bacteria / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000494:pharmacology; D002475:Cellobiose / Q000494:pharmacology; D003773:Dental Plaque / Q000378:metabolism* / Q000382:microbiology; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D006801:Humans; D008297:Male; D013400:Sugar Acids / Q000378:metabolism*; D013863:Thioglucosides / Q000494:pharmacology
D002241:Carbohydrates; D003837:Deoxy Sugars; D013400:Sugar Acids; D013863:Thioglucosides; D002475:Cellobiose; D003847:Deoxyglucose