Acute renal tubular dysfunction following cis-dichlorodiammine platinum therapy.
Following single, high dose (3 mg/kg) DDP therapy seven patients with head and neck cancer developed significant serum electrolyte disturbances. Hypocalcemia, hypomagnesemia, hypokalemia, and hypophosphatemia were the most clinically significant electrolyte abnormalities. Renal clearance studies support a pathologic mechanism of a diffuse renal tubular leakage not associated with renal failure.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D001806:Blood Urea Nitrogen; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D004573:Electrolytes / Q000097:blood; D006258:Head and Neck Neoplasms / Q000188:drug therapy; D006801:Humans; D007671:Kidney Concentrating Ability / Q000187:drug effects; D007683:Kidney Tubular Necrosis, Acute / Q000097:blood / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged
D004573:Electrolytes; D002945:Cisplatin