NMR chemical shift imaging in three dimensions.
A method for obtaining the three-dimensional distribution of chemical shifts in a spatially inhomogeneous sample using Fourier transform NMR is presented. The method uses a sequence of pulsed field gradients to measure the Fourier transform of the desired distribution on a rectangular grid in (k,t) space. Simple Fourier inversion then recovers the original distribution. An estimated signal/noise ratio of 20 in 10 min is obtained for an "image" of the distribution of a 10 mM phosphorylated metabolite in the human head at a field of 20 kG with 2-cm resolution.
D005583:Fourier Analysis; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008961:Models, Structural; D010710:Phosphates / Q000378:metabolism*
D010710:Phosphates