Acquired dyserythropoiesis with abnormal intercellular contacts between erythroblasts. Report of a patient with chronic myeloid leukaemia and hepatocarcinoma.
A case of acquired dyserythropoiesis with inter-erythroblastic connections is reported in a patient with chronic myeloid leukaemia, developing a terminal acute hepatic failure related to hepatocarcinoma. The erythroblastic series was abundant but only made of clusters grouping 10 to 20 closely adherent cells. The cellular membranes showed linear junctions or were interdigitated and the intercellular space was occupied with electron dense ferritin granules. This non specific aspect of dyserythropoiesis may be related to the hepatic carcinoma, which was probably induced by busulfan therapy.
D000328:Adult; D000743:Anemia, Hemolytic / Q000473:pathology*; D002450:Cell Communication; D004900:Erythroblasts / Q000473:pathology*; D004912:Erythrocytes / Q000473:pathology*; D006801:Humans; D007365:Intercellular Junctions / Q000648:ultrastructure; D007951:Leukemia, Myeloid / Q000150:complications* / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications*; D008297:Male