The release of prostaglandins in human aqueous humour following intraocular surgery. Effect of indomethacin.
Inflammatory reaction to ocular trauma is known to be related to prostaglandins. To further evaluate this phenomenon in human, PGE1 and E2 were measured by R.I.A. after silicic acid chromatography in aqueous humour of 26 patients before and 3 days after surgery for unilateral senile cataract (posterior chamber implant after extracapsular surgery). 13 out of these patients were treated with indomethacin by enteral route and 13 were not treated. PGE2 levels increased in all non-treated patients from: m less than 214 pg/ml before surgery, to 2666 +/- 869 pg/ml (range: 257 - 8728) p less than 0.001 after surgery. PGE2 levels did not increase in indomethacin-treated patients. PGE1 levels did not increase significantly in non-treated as in treated patients. 1) Intra-ocular surgery is followed in human by a constant increase of the only PGE2 in the aqueous humour. 2) Indomethacin inhibits this increase. 3) The post-surgical increase in the permeability of blood-aqueous barrier appears to be related to a release of PGE2.
D000527:Alprostadil; D001082:Aqueous Humor / Q000187:drug effects / Q000378:metabolism*; D002387:Cataract Extraction; D015232:Dinoprostone; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D011453:Prostaglandins / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism
D011453:Prostaglandins; D011458:Prostaglandins E; D000527:Alprostadil; D015232:Dinoprostone; D007213:Indomethacin