Antitumor activity of picolinic acid in CBA/J mice.
The growth of a solid tumor induced by im implantation of Ehrlich ascites tumor cells in inbred CBA/J mice was retarded by treatment with an iron chelator, picolinic acid (PLA). Survival of the mice was also significantly increased after PLA treatment. However, the iron chelator deferoxamine had no such effects; tumor growth was slightly enhanced, and survival was decreased.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D003676:Deferoxamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D010848:Picolinic Acids / Q000627:therapeutic use* / Q000633:toxicity; D011379:Prognosis
D010848:Picolinic Acids; D003676:Deferoxamine