Granulocyte transfusions in acute leukaemia. Regeneration of granulopoiesis as determining factor of survival.
40 patients with acute leukaemia and severe granulocytopenia were treated with granulocyte transfusions for bacteriologically documented or clinically suspected septicaemia. The patients received an average of 5 transfusions each with 2.1 X 10(10) granulocytes per m2 body surface area per day. 26 patients showed clinical benefit from transfusion therapy as documented by the course of blood cultures, local lesions and fever. Only patients with regeneration of granulopoiesis had definite benefit from granulocyte transfusions. All other patients died ultimately from septicaemia.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D006098:Granulocytes / Q000637:transplantation*; D006410:Hematopoiesis; D006801:Humans; D007938:Leukemia / Q000097:blood*; D007951:Leukemia, Myeloid / Q000097:blood*; D015470:Leukemia, Myeloid, Acute / Q000097:blood*; D008875:Middle Aged; D018805:Sepsis / Q000401:mortality / Q000628:therapy