Modification of toxicity of violamycin BI (VBI) by complex formation with DNA, metal ions, and by pretreatment with alpha-tocopherol.
In connection with studies on lowering the toxicity of violamycin BI (VBI) the intravenous (i.v.) LD50 values were determined in mice for VBI, VBI complexed with DNA, Fe3+ or Pt2+, and after pretreatment with alpha-tocopherol. The results indicate that the toxicity of VBI is reduced by complex formation with DNA or ferric ions including a partial decrease of the antimicrobial and antiviral activity.
D000617:Aminoglycosides / Q000037:antagonists & inhibitors / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors / Q000633:toxicity*; D000998:Antiviral Agents; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA / Q000494:pharmacology*; D008670:Metals / Q000494:pharmacology*; D051379:Mice; D014810:Vitamin E / Q000494:pharmacology*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D008670:Metals; D014810:Vitamin E; C022171:violamycin BI; D004247:DNA