Positive peritoneal cytology in corpus carcinoma. Report of a fatal outcome.
A 64-year-old patient underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy in October, 1978 for a Stage IA, grade 2 papillary adenocarcinoma of the endometrium. Peritoneal washings contained numerous malignant cells, although the tumor invaded the myometrium only superficially. Two weeks after operation, 12 mCi of P32 were instilled into the peritoneal cavity. In May, 1979, laparotomy was performed for clinical obstruction of the small intestine and revealed diffuse peritoneal, omental, and hepatic metastases. Radiation changes involved the terminal ileum, ascending and sigmoid colon; an ileorectal fistula was also identified. The factors that might cause malignant cells to be present in the peritoneal cavity and the ideal treatment of such patients have yet to be determined. THe risk of intraperitoneal P32 might outweigh its benefits.
D000231:Adenocarcinoma, Papillary / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D001202:Ascitic Fluid / Q000166:cytology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary*; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000556:secondary*; D010761:Phosphorus Radioisotopes / Q000627:therapeutic use; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000473:pathology*
D010761:Phosphorus Radioisotopes