title: Lysozyme (muramidase) and hemolytic complement (CH50U) in sera of beagle dogs and minipigs after longterm application of different preparations of estrogens and gestagens.
abstract: In studies for the chronic toxicity of estrogens and gestagens, lysozyme and hemolytic complement (CH50U) in sera of beagle dogs and minipigs were measured. Various doses of the sexsteroids were given: 0.01 mg, 0.1 mg and 1.0 mg/kg respectively. The influence of the steroids on the tested parameters after an application for 6 months was not significant, only in a single series with unphysiologically, high dosages of the preparations were some values changed significantly.
mesh_terms: D000818:Animals; D003165:Complement System Proteins / Q000378:metabolism*; D004285:Dogs; D045166:Estradiol Congeners / Q000494:pharmacology*; D009113:Muramidase / Q000097:blood*; D045167:Progesterone Congeners / Q000494:pharmacology*; D013552:Swine
chemical_list: D045166:Estradiol Congeners; D045167:Progesterone Congeners; D003165:Complement System Proteins; D009113:Muramidase