Effect on prostaglandin F 2 alpha on sperm motility in vitro.
The effect of prostaglandin F 2 alpha (PGF2 alpha) on sperm motility in ejaculates from 53 subfertile men was investigated. The addition of PGF2 alpha in a concentration of 25 00 ng/ml isotonic salt solution to sperm samples resulted in a highly significant (p less than 0.025) increase in sperm motility; however, only two out of three samples responded in this way, the remainder being unaffected. Mean progressive sperm motility in responders increased by 32.8% of baseline value (determined 2h after liquefaction). In higher concentrations (25 000 ng/ml aliquots), PGF2 alpha was ineffective.
D015237:Dinoprost; D006801:Humans; D066298:In Vitro Techniques; D007248:Infertility, Male / Q000503:physiopathology; D008297:Male; D011460:Prostaglandins F / Q000494:pharmacology*; D013081:Sperm Motility / Q000187:drug effects*
D011460:Prostaglandins F; D015237:Dinoprost