[Intra-arterial chemotherapy for the treatment of tumors of the nasal sinuses. Results in 50 cases (author's transl)].
Fifty patients with primary epidermoid carcinomas of the nasal sinuses were treated by intra-arterial chemotherapy, alone (2 fatal iatrogenic accidents occurred) or in association with surgery and/or radiotherapy (48 cases). Adverse reactions due to chemotherapy were noted in 11 patients (22%), and two of these were fatal (4%). In eleven patients (22%) the initial curative chemotherapy was unsuccessful and all died after a mean survival period of 12 months. Local recurrence was observed in 7 patients (14%), the mean survival period being 11,5 months, and in 6 patients (12%) with local glandular involvement the mean period was 15 months. Identical survival rates of 57% after 3 years (8/14) and 50% after 5 years (6/12) were observed in 14 cases with endosinusal forms and 14 patients in whom the infrastructures were treated. In 22 patients there was exteriorization of the lesion, and the survival rate was 31% after 3 years (7/22) and 15% after 5 years (3/19). All 7 patients with pterygomaxillary lesions died within 3 years. Overall results in the 50 patients treated show that: -- 23/50 (46%) survived for 3 years -- 15/43 (35%) for 5 years -- 5/19 (26%) for 10 years.
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000628:therapy; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010255:Paranasal Sinus Neoplasms / Q000188:drug therapy* / Q000628:therapy; D011379:Prognosis
D000970:Antineoplastic Agents
apport de la chimiothérapie intra-artérielle dans le traitement des tumeurs naso-sinusiennes. A propos de 50 observations.