title: A study of acute respiratory disease in the community of Port Chalmers. III. Efficacy of influenza virus subunit vaccines in 1973, 1974 and 1975.
abstract: An evaluation of the efficacy of influenza virus subunit vaccine was undertaken during a study of acute respiratory disease in the semi-isolated community of Port Chalmers, New Zealand. In 1973, the administration of a vaccine containing A/England/42/72(H3N2) and B/Roma/1/67 stains was found to produce HI antibody titres greater than or equal to 1:40 to the A and B components in 50 percent of 32 subjects. There was no significant NI antibody response to the A component. During an epidemic of A/Port Chalmers/I/73(H3N2) occurring three to four months after vaccination, vaccinees were not protected from clinical infection. Sixty and ninety-nine subjects received vaccine containing A/Port Chalmers/1/73 and B/Hong Kong/8/73 in 1974 and 1975 respectively. In 1974 all 60 subjects received a second dose of vaccine which was shown to have little effect on the distribution of HI antibody titres. The benefits of annual vaccination in this general practice are unclear.
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007252:Influenza Vaccines; D007251:Influenza, Human / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control; D008875:Middle Aged; D009520:New Zealand; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines