Action of mitomycin C on testicular steroidogenesis in immature rats.
Treatment with mitomycin C resulted in a decrease in the testicular delta 5-3 beta-hydroxysteroid dehydrogenase level along with a fall of Leydig cell nuclear area. Following the same treatment the significant fall of sex accessory organ weights and testicular accumulation of ascorbic acid and cholesterol were noted. On the basis of above evidence it is suggested that mitomycin C probably suppressed testicular steroidogenesis.
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D007985:Leydig Cells / Q000187:drug effects; D008297:Male; D008937:Mitomycins / Q000494:pharmacology*; D009929:Organ Size; D011375:Progesterone Reductase / Q000378:metabolism*; D051381:Rats; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism
D008937:Mitomycins; D002784:Cholesterol; D015096:3-Hydroxysteroid Dehydrogenases; D011375:Progesterone Reductase; D001205:Ascorbic Acid