Testing of drugs for nephrotoxicity. General principles and minimal criteria.
A programme for testing of drugs for nephrotoxicity is described. The characterization of nephrotoxic effects is possible using a selection of morphological and physiological methods. The validity of the different methods is discussed. The measurement of renal enzyme excretion is a very sensitive method for the detection of an injury of kidney. Alterations of renal excretion of electrolytes and p-aminohippurate can be measured in a simple diuresis study.
D000818:Animals; D004798:Enzymes / Q000652:urine; D007668:Kidney / Q000378:metabolism; D007674:Kidney Diseases / Q000139:chemically induced*; D004364:Pharmaceutical Preparations / Q000652:urine; D014116:Toxicology; D014882:Water-Electrolyte Balance
D004798:Enzymes; D004364:Pharmaceutical Preparations