title: [Therapy of hypertensive crises with a mono-substance with alpha- and beta-blocking properties (labetalol)].
abstract: For treatment of hypertensive emergencies 36 patients received an intravenous bolus of 100 mg labetalol. The mean blood pressure of the whole group was decreased from 220/128 mm Hg to 167/107 mm Hg. Mean heart rate dropped from 85 to 76 per minute. 7 patients did not respond to treatment. Thereafter 4 patients received a second dose of 100 mg or 500 mg labetalol respectively, whereupon 2 showed a distinct drop in blood pressure. Simple handling and intensive efficacy and the lack of troublesome side effects recommend labetalol for the treatment of hypertensive emergencies.
mesh_terms: D000328:Adult; D000368:Aged; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D006977:Hypertension, Renal / Q000188:drug therapy; D007741:Labetalol / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
chemical_list: D004983:Ethanolamines; D007741:Labetalol
vernacular_title: Therapie von Hypertoniekrisen durch eine Monosubstanz mit alpha- und betablockierenden Eigenschaften (Labetalol).