YAC-Lymphoma bearing induces functional changes in bone marrow derived mononuclear phagocytes.
Bone marrow derived mononuclear phagocytes (BMDMP) differentiated in vitro from bone marrows of YAC-lymphoma bearing mice and Corynebacterium parvum (CP)-inflamed mice shown to differ in several functional parameters from those derived from bone marrows of control mice. The former 2 BMDMP populations expressed: (a) an increased level of acid phosphatase activity; (b) an increased degree of zymosan-induced chemiluminescence reaction; (c) a lower sensitivity of the proliferative capacity to prostaglandin E2 (PGE2), as compared to the BMDMP population from normal mice. These data suggest that YAC-lymphoma bearing in A/J mice induces similarly to inflammatory stimuli changes in the functional capacity of bone marrow mononuclear phagocyte precursor cells.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D015232:Dinoprostone; D006410:Hematopoiesis / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000503:physiopathology*; D007249:Inflammation / Q000503:physiopathology; D008163:Luminescent Measurements; D008223:Lymphoma / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000503:physiopathology; D010586:Phagocytes / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D011425:Propionibacterium acnes; D011458:Prostaglandins E / Q000494:pharmacology; D015054:Zymosan / Q000494:pharmacology
D011458:Prostaglandins E; D015054:Zymosan; D000135:Acid Phosphatase; D015232:Dinoprostone