Cellular pharmacokinetics of aclacinomycin A in cultured L1210 cells. Comparison with daunorubicin and doxorubicin.
Aclacinomycin, which is more lipophilic than daunorubicin and doxorubicin, is taken up and released more rapidly and extensively by L1210 cells. After 5 h of incubation 91% of aclacinomycin is found in the nuclei of L1210 cells and the drug present in the post-nuclear fraction is distributed between the lysosomes and the cytosol. After an incubation of 5 h aclacinomycin decreases the density of the lysosomes. This effect is not observed either with doxorubicin or daunorubicin or when the cells are incubated with aclacinomycin for only 30 min.
D015250:Aclarubicin; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000378:metabolism*; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D004273:DNA, Neoplasm / Q000378:metabolism; D003630:Daunorubicin / Q000378:metabolism*; D004317:Doxorubicin / Q000378:metabolism*; D007700:Kinetics; D007939:Leukemia L1210 / Q000378:metabolism*; D051379:Mice; D008811:Mice, Inbred DBA; D009279:Naphthacenes / Q000378:metabolism; D013347:Subcellular Fractions / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D004273:DNA, Neoplasm; D009279:Naphthacenes; D015250:Aclarubicin; D004317:Doxorubicin; D003630:Daunorubicin