Eicosanoid production in rat blood as affected by fasting and dietary fat.
The effects of fasting and dietary linoleate on eicosanoid production in clotting rat blood incubated 10 minutes at 37 degrees C was studied. Fasting increased eicosanoid synthesis. Dietary manipulation of eicosanoid levels was best demonstrated in the fed rat model. TXB2, PGE2, F2 alpha, and E1 synthesis increased when dietary linoleate increased from 0.0 to 0.4% calories; from 0.4 to 29% linoleate calories there was no change in PG synthesis, but a decrease in TXB2 production was apparent.
D000818:Animals; D002940:Circadian Rhythm; D004041:Dietary Fats / Q000494:pharmacology*; D015232:Dinoprostone; D004537:Eicosanoic Acids / Q000097:blood*; D005215:Fasting; D005260:Female; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000494:pharmacology; D011458:Prostaglandins E / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013929:Thromboxane B2 / Q000097:blood
D004041:Dietary Fats; D004537:Eicosanoic Acids; D008041:Linoleic Acids; D011458:Prostaglandins E; D013929:Thromboxane B2; D019787:Linoleic Acid; D015232:Dinoprostone