title: Effects of pentobarbital on contractile responses of feline cerebral arteries.
abstract: The effects of pentobarbital on the contractile responses of isolated feline middle cerebral arteries have been examined. In the presence of pentobarbital (3 x 10(-4)M), the maximum contractions effected by potassium, noradrenaline, and prostaglandin F2 alpha were reduced by 37 +/- 3, 69 +/- 3, and 10 +/- 6%, respectively. The results caution against the use of pentobarbital as an anaesthetic agent in investigations of cerebrovascular reactivity.
mesh_terms: D000818:Animals; D002415:Cats; D002536:Cerebral Arteries / Q000187:drug effects*; D015237:Dinoprost; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D011460:Prostaglandins F; D015237:Dinoprost; D010424:Pentobarbital; D011188:Potassium; D009638:Norepinephrine