title: Reactivity of xenogeneic antihuman Ia antisera with the I-C subregion of the murine major histocompatibility complex. I. Genetic studies.
abstract: Several rabbit xenoantisera raised against human serum Ia antigens have been shown to detect murine lymphocyte antigens. The murine system detected was shown to be polymorphic and expressed on B cells and not T cells. Serological analysis of recombinant H-2 strains demonstrated that two of the antisera recognized products of the I-Cd subregion, and one antiserum recognized products of the I-Cb subregion, thus clearly establishing the existence of the I-C subregion in these two haplotypes. However, as the I-Cd subregion is classically described by the Ia.6 specificity present on T cells and xenoantisera detect a product on B cells, the indication is that the I-C region, like I-A and I-J, complex and contains genes coding for specificities on T cells or B cells.
mesh_terms: D000042:Absorption; D000818:Animals; D006183:H-2 Antigens / Q000235:genetics*; D006238:Haploidy; D000949:Histocompatibility Antigens Class II / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D008214:Lymphocytes / Q000276:immunology; D008285:Major Histocompatibility Complex; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D011817:Rabbits; D011995:Recombination, Genetic
chemical_list: D006183:H-2 Antigens; D000949:Histocompatibility Antigens Class II; D007106:Immune Sera