[Porphobilinogen synthase activity of the erythrocytes in acute leukemia].
The activity of PBG-S enzyme in erythrocytes was studied by referential method of Berlin and Schaller in a control group of 40 healthy males and females and 60 patients with acute leucosis (24 males and 36 females), 40 of them with acute myelogenic leucosis (AML) and 20 with acute lymphoblast leucosis (ALL). Enzyme activity was determined in another group of 15 patients, (8 females and 7 males) followed-up during the initial stage, remission and relapse of acute leucosis. PBG-S activity was moderately diminished in patients with OML, revealing no significant difference as compared with the controls, with those with OLL. It was increased in the patients in acute leucosis remission as compared with the beginning and the relapse. The changes found could be of certain clinical significance.
D000328:Adult; D000740:Anemia / Q000201:enzymology / Q000209:etiology; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications / Q000201:enzymology*; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000201:enzymology; D000623:Porphobilinogen Synthase / Q000097:blood*
D000623:Porphobilinogen Synthase
Aktivnost na porfobilinogen sintezata v eritrotsitite na bolnite s ostra levkoza.