Osteogenic sarcoma following Hodgkin's disease.
The cases of two children who developed osteogenic sarcoma of the distal femur following prolonged remission of Hodgkin's disease are reported. These cases are unique in that the sarcoma developed in an area not previously irradiated. This occurrence suggests the possibility of genetic susceptibility to primary cancers in certain individuals, although prior chemotherapy may have contributed to this occurrence.
D001859:Bone Neoplasms / Q000150:complications* / Q000235:genetics; D002675:Child, Preschool; D005269:Femur; D006689:Hodgkin Disease / Q000150:complications* / Q000235:genetics; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000150:complications* / Q000235:genetics; D010375:Pedigree