Acute monocytic leukemia complicating combined-modality therapy for localized childhood Ewing's sarcoma.
Rapidly fatal acute monocytic leukemia occurred in an 11-year-old by 33 months after the beginning of irradiation and chemotherapy for non-metastatic pelvic Ewing's sarcoma. At autopsy, no recurrent primary disease was seen. An analysis of this case together with a review of the literature suggests therapy-related leukemogenesis. Thus, the decline in mortality rate for childhood cancer may be accompanied by an increased incidence of second neoplasms in cured children having the potential of a normal life span.
D000970:Antineoplastic Agents / Q000009:adverse effects; D002648:Child; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000209:etiology*; D007953:Leukemia, Radiation-Induced / Q000209:etiology*; D008297:Male; D011878:Radiotherapy / Q000009:adverse effects; D012512:Sarcoma, Ewing / Q000628:therapy*
D000970:Antineoplastic Agents