Characterization of the protective effect of radioprotective substances by means of long-term changes in oxygen consumption.
A comparison of long-term hypothermic effects of radioprotective substances and their protective effectiveness was carried out in mice after acute and prolonged irradiation. As radioprotective substances were used AET, cystamine, serotonine, 5-methoxytryptamine, cysteamine-S-phosphate, sodium fluoroacetate and some double combinations of these substances. The irradiation was carried out with dose rates 38.3 and 612.5 mGy/min, the hypothermic reaction was evaluated according to total oxygen consumption, measured during 5 hours after the drug administration. The results demonstrated the existence of a correlation between the suppression of metabolic processes and both short-term and long-term protective effectiveness of radioprotective substances. The protective effectiveness of a drug is the higher, the greater decrease of oxygen consumption is induced by this substance in the investigated time interval. An analogous dependence was also demonstrated between the duration of hypothermic and radioprotective effects. The found correlation is valid for both acute and prolonged irradiation (correlation coefficient 0.79-0.87; p < 0.01).
D008735:5-Methoxytryptamine / Q000494:pharmacology*; D000818:Animals; D003538:Cystamine / Q000494:pharmacology*; D003543:Cysteamine / Q000494:pharmacology*; D005463:Fluoroacetates / Q000494:pharmacology*; D007035:Hypothermia; D008297:Male; D008433:Mathematics; D051379:Mice; D010101:Oxygen Consumption / Q000187:drug effects / Q000528:radiation effects*; D011829:Radiation Dosage; D012701:Serotonin / Q000494:pharmacology*; D013997:Time Factors; D014363:Tryptamines / Q000494:pharmacology*; D000338:beta-Aminoethyl Isothiourea / Q000494:pharmacology*
D005463:Fluoroacetates; D014363:Tryptamines; D000338:beta-Aminoethyl Isothiourea; D012701:Serotonin; D008735:5-Methoxytryptamine; D003543:Cysteamine; D003538:Cystamine