Sixteen types of epidermolysis bullosa. On the clinical discrimination, therapy and prenatal diagnosis.
The 16 types of hereditary epidermolysis bullosa and the acquired type have been reviewed elsewhere (25). After a brief summary of the genetic and electron-microscopical diagnosis, this article discusses clinical signs and symptoms that are of help in discriminating between the different epidermolysis bullosa entities. Several distinct entities with identical electron-microscopical findings but very different course and prognosis exist. Despite the great value of an electron-microscopic diagnosis, minute clinical observation is therefore as important as ever. Recent advances in therapy and prenatal diagnosis are discussed.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001768:Blister / Q000175:diagnosis / Q000473:pathology; D002675:Child, Preschool; D004820:Epidermolysis Bullosa / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006358:Hot Temperature / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008297:Male; D009092:Mucous Membrane / Q000473:pathology; D009262:Nails / Q000473:pathology; D010672:Phenytoin / Q000627:therapeutic use; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012883:Skin Ulcer / Q000473:pathology
D000305:Adrenal Cortex Hormones; D010672:Phenytoin