title: Induction of lung cancers in preselected, localized sites in the dog.
abstract: Cancers were induced in 10 dogs in preselected sites within the lung. These 10 animals were among 89 dogs enrolled in 10 protocols with different carcinogens, doses, and techniques over 6 years. The 10 dogs that developed cancers were included in five of these protocols; 4 of the cancers were included in one of the protocols. The administered carcinogens included the aromatic hydrocarbons benzo[a]pyrene (BP), N-methyl-N-nitrosourea (MNU), 7, 12-dimethylbenz[a]anthracene (DMBA), 3-methylcholanthrene (MCA), and yttrium-91 (91Y) beta radiation. The techniques of application included intrabronchial and intrapulmonary sustained-release implants of DMBA and 91Y, serial intrabronchial submucosal injections of BP, DMBA and MCA, or topical application of MNU. The intervals from the first application of a carcinogen to the diagnosis of malignant disease ranged from 8 to 56 months. Of the tumors induced, 9 were centrally located squamous cell carcinomas and 1 was a peripherally located carcinosarcoma. Four of the dogs were killed or died with stage 3 disease. The remaining 6 dogs are alive and are being evaluated serially; all 6 are in stage 1.
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology; D002296:Carcinosarcoma / Q000139:chemically induced / Q000473:pathology; D004285:Dogs; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000473:pathology; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology