[Mycological long-term examinations in hospitalized children with haemoblastoses and solid tumours].
In 54 children with haemoblastoses and solid tumours and 136 healthy children as control group in long-term examinations lasting several months the yeast infection was quantitatively established in the faeces and in the urine as well as coarsely quantitatively in the oral cavity and by means of cell agglutination antibodies against Candida albicans were proved. With 77.8% the ill children were significantly more frequently infested by Candida albicans than the healthy children with 38.2%. In the faeces the Candida albicans infection reached values of more than 10(7) cells/g. This size of infection in patients with leucosis in the stage of the primary disease or a recidivation occurred significantly more frequently than in patients in full remission. With high quantities of Candida albicans in the faeces clinical symptoms of aphthous stomatitis (in 31.5% of the patients), findings of fungi in the urine (in altogether 29.6% of the patients) and increased antibody titres up to 1 : 2 048 were concomitant. A permanent mycological control and aimed antimycotic treatment are recommended for children with malignant diseases.
D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects; D002177:Candidiasis / Q000209:etiology; D002180:Candidiasis, Oral / Q000209:etiology; D002648:Child; D002673:Child, Hospitalized; D002675:Child, Preschool; D005260:Female; D006689:Hodgkin Disease / Q000150:complications / Q000628:therapy*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007223:Infant; D007945:Leukemia, Lymphoid / Q000150:complications / Q000628:therapy*; D008297:Male; D009181:Mycoses / Q000209:etiology*
D000970:Antineoplastic Agents
Mykiologische Langzeituntersuchungen bei stationär betreuten Kindern mit Hämoblastosen und soliden Tumoren.