Rapid taste-aversion learning by an isolated molluscan central nervous system.
The isolated lips and nervous system of the terrestrial slug Limax maximus will produce some of the feeding behavior of the intact animal; i.e., they generate the rhythmic neural activity characteristic of ingestion in response to food extracts applied to the lips. This preparation will respond to a variety of food extracts that elicit feeding in the whole animal. This provides the opportunity for aversive conditioning experiments involving taste discrimination. Pairing lip chemostimulation by attractive food extracts with lip chemostimulation by using bitte plant secondary substances can cause the isolatd brain to selectively suppress its neural response to one food extract while remaining responsive to another. Such isolated brains can learn after one or two trials and retain the learning for more than 8 hr.
D000200:Action Potentials; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology; D003078:Colchicine / Q000494:pharmacology; D005724:Ganglia / Q000502:physiology; D047348:Hydrolyzable Tannins / Q000494:pharmacology; D066298:In Vitro Techniques; D008974:Mollusca / Q000502:physiology*; D009538:Nicotine / Q000494:pharmacology; D013649:Taste / Q000502:physiology; D013997:Time Factors
D047348:Hydrolyzable Tannins; D009538:Nicotine; D003078:Colchicine