Danazol inhibition of steroidogenesis in the human corpus luteum.
In human corpus luteum (CL) microsomes, danazol inhibited 3 beta-hydroxysteroid dehydrogenase, 17,20-lyase, 17 alpha-hydroxylase, and 17 beta-hydroxysteroid dehydrogenase enzymes. Danazol did not inhibit aromatase. The observation that danazol can directly inhibit multiple enzymes of CL steroidogenesis may provide a molecular basis for explaining previous reports that danazol inhibits CL steroidogenesis in the monkey in vivo.
D000328:Adult; D001141:Aromatase / Q000378:metabolism; D003338:Corpus Luteum / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D003613:Danazol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006913:Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008190:Lyases / Q000037:antagonists & inhibitors; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors; D011245:Pregnadienes / Q000494:pharmacology*
D011245:Pregnadienes; D006899:Mixed Function Oxygenases; D006913:Hydroxysteroid Dehydrogenases; D001141:Aromatase; D008190:Lyases; D003613:Danazol