Cell penetration by exogenous superoxide dismutase.
The fixation and penetration of liposomal encapsulated dismutase (SOD) with human erythrocytes and other eucaryote cells is described. Such preparations not only facilitate fixation and penetration of the enzyme as a function of liposome composition, but also confer an increased physiological life time as well as a marked organ specificity. Such packed SOD could be useful for a pharmacological application of the enzyme.
D000818:Animals; D001692:Biological Transport; D002417:Cattle; D004912:Erythrocytes / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage*; D008214:Lymphocytes / Q000378:metabolism / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D013482:Superoxide Dismutase / Q000097:blood* / Q000627:therapeutic use
D008081:Liposomes; D013482:Superoxide Dismutase