Pharmacological influences of pentoxifylline on red cell filterability and 2-3 diphosphoglycerate.
The diabetic's impairment of the red cell filterability is all the more important if the diabetic subject is suffering from an acute and progressive lower limb arteriopathy. Red cell 2-3 diphosphoglycerate (2-3 DPG) increases when red cell filterability decreases among these patients. Pentoxifylline (i.v. 600 mg per day) produces a rapid initial improvement of red cell filterability and then increases red cell 2-3 DPG level.
D019794:2,3-Diphosphoglycerate; D000328:Adult; D001158:Arteries / Q000473:pathology; D003920:Diabetes Mellitus / Q000097:blood; D004163:Diphosphoglyceric Acids / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects*; D005121:Extremities / Q000098:blood supply; D006801:Humans; D008851:Micropore Filters; D008875:Middle Aged; D010431:Pentoxifylline / Q000494:pharmacology*; D013805:Theobromine / Q000031:analogs & derivatives*
D004163:Diphosphoglyceric Acids; D019794:2,3-Diphosphoglycerate; D013805:Theobromine; D010431:Pentoxifylline