Vertebral disc space infection and osteomyelitis due to Candida albicans in a patient with acute myelomonocytic leukemia.
A 67-year old man with acute myelomonocytic leukemia had Candida albicans fungemia during induction chemotherapy. Bilateral pulmonary infiltrates and hepatic granulomata containing yeast forms and septate hyphae developed, but cultures of the hepatic tissue failed to grow a fungus. Although his pulmonary and liver disease improved following appropriate therapy, vertebral osteomyelitis due to Candida albicans developed approximately 12-15 weeks after the original fungemia. The fungal osteomyelitis was successfully treated with amphotericin B and 5-fluorocytosine. This case illustrates the need for early diagnosis and aggressive treatment of fungal infections in patients with leukemia.
D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D002177:Candidiasis / Q000150:complications* / Q000188:drug therapy; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D007403:Intervertebral Disc; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008159:Lumbar Vertebrae; D008297:Male; D010019:Osteomyelitis / Q000209:etiology*; D011859:Radiography; D013122:Spinal Diseases / Q000000981:diagnostic imaging / Q000209:etiology*
D000666:Amphotericin B; D005437:Flucytosine