Changes of pharmacokinetics and metabolism of sulfadimidine in endotoxin pretreated rabbits.
Changes of pharmacokinetics and acetylation of sulfadimidine (SDM) were studied in endotoxin pretreated rabbits. With increasing doses of endotoxin the levels of intravenously administered SDM were lower. The acetylation rate was reduced in urine of rabbits after medium endotoxin doses.
D000107:Acetylation; D000818:Animals; D004731:Endotoxins / Q000494:pharmacology*; D005260:Female; D007700:Kinetics; D008297:Male; D011817:Rabbits; D013418:Sulfamethazine / Q000097:blood / Q000378:metabolism*
D004731:Endotoxins; D013418:Sulfamethazine