title: The effects of Surgicel on bone formation.
abstract: The subperiosteal implantation of Surgicel has been advocated for the stimulation of bone formation by some authors. A clinical trial in five patients demonstrated no radiographic evidence of bone formation after 12 months. An experimental model was designed in the rabbit. This study also demonstrated no radiographic or histologic evidence of bone formation with the use of subperiosteal Surgicel. The further use of Surgicel for the stimulation of bone formation is not recommended.
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology; D002482:Cellulose / Q000031:analogs & derivatives*; D002483:Cellulose, Oxidized / Q000494:pharmacology*; D003094:Collagen / Q000494:pharmacology; D006801:Humans; D010012:Osteogenesis / Q000187:drug effects*; D010521:Periosteum / Q000187:drug effects / Q000502:physiology; D011817:Rabbits
chemical_list: D002483:Cellulose, Oxidized; C013695:Surgicel; D002482:Cellulose; D003094:Collagen