Studies of the vivo uptake of Ga-67 by an experimental abscess: concise communication.
The blocking of Ga -67 plasma protein-binding sites-by administration of scandium citrate, ferric citrate, and a colloidal hydrous ferric oxide preparation-reduced the uptake of Ga-67 in normal soft tissues and also that in the viable portion of an experimental abscess. On the other hand, enhancement of Ga-67 plasma protein binding by administration of rabbit apotransferrin increased Ga-67 uptake in both abscess and normal soft tissues. These results indicate that the pathways of Ga-67 from blood into inflammatory processes and normal soft tissues may be similar. However, when Ga-67 plasma protein binding was increased by inducing anemia, a markedly decreased Ga-67 uptake in the abscess resulted, whereas uptake in normal soft tissue was still elevated. It is possible that the discrepancy between the effects of apotransferrin and anemia on abscess-tissue uptake of Ga-67 resulted from a secondary effect produced by anemia, i.e., a decrease in the macrophage population in the abscess. Taken as a whole, the results obtained suggest that Ga-67 leaves the blood and enters inflammatory lesions by pathways that are probably quite different from those in a soft-tissue tumor, and that the routes for abscesses may be similar to those occurring in normal soft tissues.
D000038:Abscess / Q000000981:diagnostic imaging* / Q000378:metabolism; D000740:Anemia / Q000378:metabolism; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D005710:Gallium Radioisotopes / Q000008:administration & dosage / Q000378:metabolism*; D008297:Male; D011485:Protein Binding; D011877:Radionuclide Imaging; D051381:Rats; D011916:Rats, Inbred F344; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism; D013203:Staphylococcal Infections / Q000000981:diagnostic imaging* / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects; D014168:Transferrin / Q000008:administration & dosage / Q000378:metabolism
D001798:Blood Proteins; D005710:Gallium Radioisotopes; D014168:Transferrin