title: Common 82-nucleotide sequence unique to brain RNA.
abstract: Several randomly selected cDNA clones made from rat brain polyA+RNA have unusual properties. Although the cDNA inserts are 500-1,250 base pairs long, they hybridize to a 160-nucleotide RNA species that is present in brain but not in liver or kidney. Nucleotide sequence studies of two of the clones and hybridization studies show that a common 82-nucleotide sequence is responsible for the hybridization. The same sequence is located in the second intron of a rat growth hormone gene. These studies suggest that signals called "ID sequences" may be carried in the introns of genes and prescribe their tissue-specific expression.
mesh_terms: D001483:Base Sequence; D001921:Brain / Q000502:physiology*; D002454:Cell Differentiation; D004247:DNA / Q000235:genetics; D005786:Gene Expression Regulation; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D004247:DNA