13-cis-retinoic acid: effect on urinary bladder carcinogenesis by N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide in Fischer rats.
The failure of 13-cis-retinoic acid to inhibit either the incidence or severity of bladder carcinoma in female Fischer rate initiated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) suggests that inhibition of bladder carcinogenesis by natural and synthetic retinoids is carcinogen-class specific, and adds an element of complexity to approaches in chemoprevention.
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002273:Carcinogens / Q000633:toxicity*; D005200:FANFT / Q000633:toxicity*; D005260:Female; D007536:Isomerism; D015474:Isotretinoin; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control; D051381:Rats; D011916:Rats, Inbred F344; D013844:Thiazoles / Q000633:toxicity*; D014212:Tretinoin / Q000494:pharmacology*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000517:prevention & control
D002273:Carcinogens; D013844:Thiazoles; D002084:Butylated Hydroxytoluene; D014212:Tretinoin; D005200:FANFT; D015474:Isotretinoin