title: Antagonism by PGE2 of the vasoconstriction induced by PGF2 alpha in human ovary in vitro.
abstract: Human ovaries from adnexectomy were perfused via the ovarian artery with constant volume of Thyrode's solution. Perfusion pressure was recorded while doses of PGF2 alpha or PGF2 (2.5, 5 or 10 microgram/min) were infused for 10 min. During the 10-min infusion period an increase in perfusion pressure (delta mm Hg) was observed in proportion to the doses of PGF2 alpha. PGE2 in 2.5- or 5-microgram/min doses were ineffective, but its 10-microgram/min dose increase the perfusion pressure. However, PGE2 (4 microgram/min) infused continuously into the ovary inhibited the vasoconstriction induced by PGF2 alpha, whereas the vasoconstrictor effect of noradrenaline remained unchanged.
mesh_terms: D000328:Adult; D015237:Dinoprost; D015232:Dinoprostone; D005260:Female; D006801:Humans; D008875:Middle Aged; D009638:Norepinephrine / Q000494:pharmacology; D010053:Ovary / Q000098:blood supply*; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D011458:Prostaglandins E; D011460:Prostaglandins F; D015237:Dinoprost; D015232:Dinoprostone; D009638:Norepinephrine