Philadelphia chromosome-negative chronic myelogenous leukemia with trisomy D.
Previous reports emphasize that trisomy 8 is the most common, single chromosomal abnormality in both Philadelphia (Ph1) chromosome-positive and Ph1-negative chronic myelogenous leukemia (CML). Karyotype analysis on a 78-year-old man with Ph1-negative CML showed trisomy D, confirmed on banding studies to be an extra No. 14 chromosome. Although the abnormality is likely to be related to the leukemic clone, the importance of this chromosomal deviation is not known.
D000368:Aged; D002869:Chromosome Aberrations; D002901:Chromosomes, Human, 13-15; D002904:Chromosomes, Human, 21-22 and Y; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D014314:Trisomy