title: Human osteosarcoma-derived soluble bone morphogenetic protein.
abstract: A bone morphogenetic protein (BMP) fraction obtained from the organic matrix of dentin is extractable from human osteosarcoma. A fresh en-bloc specimen excised from the femur of a 16-year-old boy was extracted with  4 M guanidine hydrochloride. The GuHCl-soluble, water-insoluble protein fraction induced new bone formation when implanted into the thigh muscles of athymic nude mice.
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins; D001842:Bone and Bones / Q000187:drug effects*; D002356:Cartilage / Q000187:drug effects*; D003094:Collagen / Q000032:analysis; D005266:Femoral Neoplasms / Q000378:metabolism*; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D006909:Hydroxyproline / Q000032:analysis; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009363:Neoplasm Proteins / Q000494:pharmacology*; D009368:Neoplasm Transplantation; D010012:Osteogenesis; D012516:Osteosarcoma / Q000378:metabolism*; D010455:Peptides / Q000032:analysis; D011506:Proteins / Q000494:pharmacology*; D014183:Transplantation, Heterologous
chemical_list: D019485:Bone Morphogenetic Proteins; D006133:Growth Substances; D009363:Neoplasm Proteins; D010455:Peptides; D011506:Proteins; D003094:Collagen; D006909:Hydroxyproline