title: Molecular structure of the octamer d(G-G-C-C-G-G-C-C): modified A-DNA.
abstract: The deoxynucleotide fragment d(GpGpCpCpGpGpCpC) was synthesized and crystallized, and its three-dimensional structure was determined by x-ray diffraction techniques to a resolution of 2.25 A. The molecule forms a right-handed double helix in which the two base pairs at either end of the molecule are in the conventional A-DNA conformation, while the central four base pairs have a modified form in which alternate residues have sugar conformations that are closer to those in B-DNA than in A-DNA. The molecules have an intermolecular contact in which the planar terminal guanine . cytosine base pair lies on the flat minor groove surface of the A-DNA helix.
mesh_terms: D003460:Crystallization; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides; D013329:Structure-Activity Relationship
chemical_list: D009841:Oligonucleotides