Phenothiazine biphasic effect on dopamine concentrations in the basal ganglia of subhuman primates.
Interpretation of data on the possible relationship between changes in endogenous putative transmitters and neuropsychiatric disorders may be altered by the use of neuroleptic agents. As one approach to this problem, we attempted to simulate the situation in man by measuring the changes in dopamine in basal ganglia of monkeys during the chronic (20 months) administration of an antipsychotic phenothiazine. Unexpectedly, a biphasic response was obtained: dopamine increased after 2 months but was markedly reduced after 20 months. Perhaps, dyskinesia is related to this biphasic effect of the antipsychotic phenothiazines.
D000818:Animals; D001479:Basal Ganglia / Q000187:drug effects* / Q000378:metabolism; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D008253:Macaca mulatta; D009043:Motor Activity / Q000187:drug effects; D009048:Motor Skills / Q000187:drug effects; D011346:Prochlorperazine / Q000494:pharmacology*; D011699:Putamen / Q000187:drug effects / Q000378:metabolism; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000378:metabolism
D011954:Receptors, Dopamine; D004298:Dopamine; D011346:Prochlorperazine