Multiple metachronous gastro-intestinal carcinoma.
A patient who developed multiple metachronous gastro-intestinal carcinoma is described. This patient has had multiple invasive carcinoma of the colon, jejunum and stomach over a 34 year period, commencing at the age of 44 years. All the colonic tumours have been Duke's A Grade, although penetration has occurred to the serosal level. The family pedigree of the propositus shows an autosomal Mendelian dominant gene pattern with a characteristic early age of onset and a significant frequency of multiple metachronous primary malignant neoplasms. Identification of this syndrome provides an opportunity to include in a surveillance program, those unaffected patients in the pedigree who have an extra risk of early development of cancer at specific sites.
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000368:Aged; D003110:Colonic Neoplasms / Q000473:pathology; D005770:Gastrointestinal Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007580:Jejunal Neoplasms / Q000473:pathology; D008297:Male; D009361:Neoplasm Invasiveness; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000473:pathology; D010375:Pedigree; D013274:Stomach Neoplasms / Q000473:pathology; D013577:Syndrome