title: 6-thioguanine as a cause of toxic veno-occlusive disease of the liver.
abstract: Lesions of hepatic veno-occlusive disease were found in the needle biopsy specimen of one patient suffering from chronic granulocytic leukaemia and in the liver at necropsy of a second patient suffering from acute myeloid leukaemia. The treatment included administration of 6-thioguanine which was the only relevant compound used in the first patient and which was combined with cytosine arabinoside in the second patient.
mesh_terms: D000328:Adult; D056486:Chemical and Drug Induced Liver Injury; D003251:Constriction, Pathologic; D005260:Female; D006503:Hepatic Veins / Q000473:pathology; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology; D008297:Male; D013866:Thioguanine / Q000009:adverse effects*; D014652:Vascular Diseases / Q000139:chemically induced / Q000473:pathology
chemical_list: D013866:Thioguanine