Bone tumours induced in rats with radioactive cerium.
A technique is described for the induction of metastasizing bone tumours in rats by local inoculation of 144cerium. Bone sarcomas develop in 90% of the animals and 74% of these had lung metastases. The tumours can be easily cultured and maintained by serial transplantations. Preliminary data of clinical, histological and kinetic characteristics of these bone tumours are given.
D000818:Animals; D001859:Bone Neoplasms / Q000209:etiology* / Q000473:pathology; D002452:Cell Count; D002478:Cells, Cultured; D002565:Cerium Radioisotopes; D004195:Disease Models, Animal; D006394:Hemangiosarcoma / Q000209:etiology* / Q000473:pathology; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D012516:Osteosarcoma / Q000209:etiology* / Q000473:pathology; D051381:Rats; D012513:Sarcoma, Experimental / Q000209:etiology / Q000473:pathology
D002565:Cerium Radioisotopes