The effect of DDVP, an organophosphorus pesticide on the humoral and cell-mediated immunity of rabbits.
The effect of daily oral administration of LD50 1/40, 1/20 and 1/10 of an organophosphate pesticide DDVP (Dichlorvos) was studied in rabbits for its effect on the humoral immune response after vaccination with Salmonella typhi, as well as on cell-mediated immunity. Serum antibody titers of treated animals showed a dose-dependent fall compared with the controls. The skin redness measured in the tuberculin test showed the same dose-dependent tendency.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D002802:Cholinesterases / Q000097:blood; D004006:Dichlorvos / Q000633:toxicity*; D007111:Immunity, Cellular / Q000187:drug effects*; D008297:Male; D011817:Rabbits; D014374:Tuberculin Test
D004006:Dichlorvos; D002802:Cholinesterases