Antibody formation to dog pulp tissue altered by camphor paramonochlorophenol via the root canal.
Pulp tissue from three experimental dogs was tested for its antigenicity before and after incubation with CMCP. Reaction to Arthus skin tests showed an increased response to pulp that had been incubated in CMCP, washed, then injected, as compared with pulp or CMCP alone. Hemagglutinating antibody titers (1:360 to 1:450 dilutions) were obtained from pulp tissue altered by CMCP. Inhibition tests showed the specificity of the antibody to be at a dilution titer of 1:350. Therefore, CMCP altered dog pulp tissue and rendered it antigenically active, and a specific humoral response was produced.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology*; D002164:Camphor / Q000276:immunology*; D002733:Chlorophenols / Q000276:immunology*; D003782:Dental Pulp / Q000276:immunology*; D003786:Dental Pulp Cavity / Q000276:immunology; D003790:Dental Pulp Necrosis / Q000276:immunology; D004285:Dogs; D004338:Drug Combinations / Q000276:immunology; D005620:Freund's Adjuvant / Q000008:administration & dosage; D007114:Immunization; D008297:Male; D012882:Skin Tests
D000906:Antibodies; D000941:Antigens; D002733:Chlorophenols; D004338:Drug Combinations; D002164:Camphor; C029804:camphorated parachlorophenol; D005620:Freund's Adjuvant