Effect of a zinc-deficient diet on the growth of an IgM-secreting plasmacytoma (TEPC-183).
A diet deficient in zinc resulted in a significant decrease in the number of inbred BALB/c female mice developing transplantable plasmacytoma TEPC-183 compared to pair-fed and ad libitum-fed control mice. The size of the tumor relative to body weight was decreased in the zinc-deficient group. Whereas the uptake of [3H]thymidine into tumor cells did not differ between the groups, the incorporation of [3H]thymidine into tumor cells was significantly reduced in the animals maintained on a zinc-deficient diet.
D000818:Animals; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004032:Diet; D005260:Female; D007075:Immunoglobulin M / Q000378:metabolism; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology; D010954:Plasmacytoma / Q000378:metabolism / Q000473:pathology*; D015032:Zinc / Q000172:deficiency*
D004273:DNA, Neoplasm; D007075:Immunoglobulin M; D015032:Zinc