Prostatic carcinoma in Egypt: epidemiology and etiology.
In Egypt, the relative frequency of prostatic carcinoma is much lower than elsewhere reported. On the other hand, carcinoma of the male breast shows a strikingly higher frequency. These findings could be related to the prevalent bilharzial infestation which impairs the liver detoxication mechanism. As a result there is an increased estrogen and diminished androgen level. These metabolic changes can contribute to the rarity of prostatic cancer and the high frequency of breast cancer in males.
D000328:Adult; D001943:Breast Neoplasms / Q000453:epidemiology; D004534:Egypt; D005260:Female; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000209:etiology; D012552:Schistosomiasis / Q000453:epidemiology