title: Stimulation of Xenopus oocyte protein synthesis by microinjected adenovirus RNA.
abstract: The ability of injected heterologous mRNAs to compete with endogenous mRNAs in Xenopus oocytes was assayed. In confirmation of previous reports, globin mRNA translation in oocytes results in a concomitant decrease in endogenous protein synthesis. In contrast, injection of adenovirus 5 mRNA into the oocyte results in a stimulation of endogenous protein synthesis. The stimulation is dose dependent and does not require nuclear transcription in the oocyte. Preliminary mapping data suggest that the stimulatory RNA is a product of one of the viral immediate early genes.
mesh_terms: D000260:Adenoviruses, Human / Q000235:genetics*; D000818:Animals; D004527:Egg Proteins / Q000096:biosynthesis; D005260:Female; D005786:Gene Expression Regulation; D005814:Genes, Viral; D009865:Oocytes / Q000378:metabolism*; D010063:Ovum / Q000378:metabolism*; D011061:Poly A; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics*; D013997:Time Factors; D014158:Transcription, Genetic; D014982:Xenopus laevis / Q000235:genetics*
chemical_list: D004527:Egg Proteins; D012333:RNA, Messenger; D012367:RNA, Viral; D011061:Poly A