Increased susceptibility to lethal effects of bacterial lipopolysaccharide in mice with B-cell leukemia.
Susceptibility to the lethal effects of bacterial lipopolysaccharide (LPS) increased more than one hundredfold in BALB/c mice given syngeneic B-cell tumor transplants. The increased susceptibility to LPS that developed during the following weeks paralleled tumor growth in the liver and spleen. The tumor-bearing animals also developed an enhanced capacity to clear colloidal carbon from the blood, consistent with increased activity of the reticuloendothelial system. Although hypersusceptibility to LPS has been reported to a number of animal models, our experiment was th first demonstration in a tumor model that susceptibility correlates with tumor burden.
D000818:Animals; D001219:Aspartate Aminotransferases; D002244:Carbon / Q000097:blood; D007945:Leukemia, Lymphoid / Q000097:blood / Q000473:pathology*; D008070:Lipopolysaccharides / Q000633:toxicity*; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009336:Necrosis; D009367:Neoplasm Staging; D009368:Neoplasm Transplantation; D009929:Organ Size; D011135:Polysaccharides, Bacterial / Q000633:toxicity*; D013154:Spleen / Q000473:pathology
D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D002244:Carbon; D001219:Aspartate Aminotransferases