Platelet-derived growth factor stimulates activity of low density lipoprotein receptors.
Partially purified platelet-derived growth factor stimulates low density lipoprotein binding and degradation in cultured aortic smooth muscle cells of monkeys by increasing the number of available low density lipoprotein receptors. When platelet-derived growth factor was added to quiescent cells, low density lipoprotein binding increased within 4-8 hr. Stimulation of low density lipoprotein receptor activity preceded stimulation of DNA synthesis by platelet-derived growth factor by 8-12 hr. Enhancement of endogenous cholesterol synthesis by platelet-derived growth factor preceded stimulation of low density lipoprotein receptor activity. These findings suggest that the platelet-derived growth factor can increase both the exogenous and endogenous supplies of cholesterol to the cell for its use during cell proliferation.
D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D002478:Cells, Cultured; D002784:Cholesterol / Q000096:biosynthesis; D006133:Growth Substances / Q000097:blood* / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008254:Macaca nemestrina; D009130:Muscle, Smooth / Q000378:metabolism; D011955:Receptors, Drug / Q000187:drug effects* / Q000378:metabolism
D006133:Growth Substances; D008077:Lipoproteins, LDL; D011955:Receptors, Drug; D002784:Cholesterol