Immunologic parameters of children with acute leucosis after cessation of polychemotherapy under repeated immunostimulation with intradermal B.C.G.
11 children with acute leucosis (10 with ALL, 1 with AML) showed a significant increase of the absolute number of lymphocytes and E-rosette forming cells in the peripheral blood after 3-years-polychemotherapy under repeated intradermal B.C.G. vaccination. Such an increase of the absolute number of lymphocytes could not be found in an analogous control group without immunostimulation. At present 14 children with acute leucosis (11 with ALL, 3 with AML) in our hematologic-oncologic primary center of Rostock are still living in a first stable remission from the first up to the third year under regular immunostimulation with intradermal B.C.G. when polychemotherapy off.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001500:BCG Vaccine / Q000627:therapeutic use*; D002648:Child; D004359:Drug Therapy, Combination; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007945:Leukemia, Lymphoid / Q000276:immunology / Q000628:therapy*; D015470:Leukemia, Myeloid, Acute / Q000276:immunology / Q000628:therapy*; D007958:Leukocyte Count; D010587:Phagocytosis / Q000187:drug effects; D012397:Rosette Formation
D000970:Antineoplastic Agents; D001500:BCG Vaccine