Low natural killer cell activity in patients with malignant lymphoma.
Natural killer (NK) cell activity was found decreased (mean value: 27.5%) in peripheral blood lymphocytes from 59 untreated patients with malignant lymphoma, when compared to 112 healthy subjects (46.3%) and to 75 cancer patients with nonlymphoid tumors (43.7%) (P less than 0.001). NK cell values were similar in patients with Hodgkin's disease (25.5%) and with non-Hodgkin's lymphoma (28.2%). Decreased NK cell activity was not correlated with age, lymphoma extension or leukocyte counts. A physiological role for NK cells in the immune surveillance against lymphoid neoplasias is discussed.
D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D006689:Hodgkin Disease / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D007951:Leukemia, Myeloid / Q000276:immunology; D008223:Lymphoma / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology; D012016:Reference Values