title: Prevention of experimentally induced cleft palate in mice.
abstract: Cleft palate was induced by giving cyclophosphamide (CPA) to pregnant mice on different days of pregnancy. Application of Solcoseryl, an oxygen stimulating, protein-free extract of the blood of calves, modified the teratogenic and embryolethal effect of CPA and significantly decreased the frequency of cleft palate (from over 70% to about 20% in some groups). This study supports the clinical findings of a reduction in the incidence of facial clefting in man following application of Solcoseryl and vitamins (Gabka, 1975).
mesh_terms: D000183:Actihaemyl / Q000627:therapeutic use*; D000818:Animals; D002972:Cleft Palate / Q000139:chemically induced / Q000517:prevention & control*; D003520:Cyclophosphamide; D005260:Female; D051379:Mice; D011247:Pregnancy; D014020:Tissue Extracts / Q000627:therapeutic use*
chemical_list: D014020:Tissue Extracts; D000183:Actihaemyl; D003520:Cyclophosphamide