Decrease in phospholipid methylation during differentiation of cultured mouse myeloid leukemia cells.
Mouse myeloid leukemia cells (M1) could be induced by various inducers to differentiate into macrophages and granulocytes. When M1 cells were cultured with inducer, the incorporation of methyl group into phosphatidylethanolamine was decreased while the incorporation of choline into phosphatidylcholine was slightly increased. The decrease of cellular phospholipid methylation may be partly due to the decrease of methyltransferase activity.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D002794:Choline / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D007942:Leukemia, Experimental / Q000378:metabolism; D007951:Leukemia, Myeloid / Q000378:metabolism*; D008660:Metabolism; D008745:Methylation; D051379:Mice; D010713:Phosphatidylcholines / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000378:metabolism; D010743:Phospholipids
D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D003907:Dexamethasone; D002794:Choline