Beta subunits of human choriogonadotropin and ovine lutropin are biologically active.
Highly purified beta subunits of human choriogonadotropin and ovine lutropin were found to possess measurable steroidogenic activity in the in vitro rat Leydig cell assay. In addition, beta subunits of these two gonadotropins were able to inhibit the biological activity of human choriogonadotropin in the rat Leydig cell assay.
D000818:Animals; D001681:Biological Assay; D006063:Chorionic Gonadotropin / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007985:Leydig Cells / Q000187:drug effects / Q000378:metabolism; D007986:Luteinizing Hormone / Q000302:isolation & purification* / Q000494:pharmacology; D046911:Macromolecular Substances; D008297:Male; D051381:Rats; D012756:Sheep; D013739:Testosterone / Q000096:biosynthesis
D006063:Chorionic Gonadotropin; D046911:Macromolecular Substances; D013739:Testosterone; D007986:Luteinizing Hormone