Rifampicin associated renal dysfunction during antituberculous therapy.
Intermittent rifampicin therapy has been reported to commonly cause a flu-like illness with chills and fever sometimes associated with acute renal failure. This report describes a fourth case of partially reversible insidious renal damage associated with continuous rifampicin therapy and provides evidence that it is not the results of light chain proteinuria as previously suggested. A retrospective review of data relating to renal function in 89 tuberculous patients indicated that increased plasma urate concentration was commonly associated with ethambutol therapy.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D001639:Bicarbonates / Q000097:blood; D003404:Creatinine / Q000097:blood; D004977:Ethambutol / Q000009:adverse effects; D005260:Female; D006029:Glycosuria / Q000139:chemically induced; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012293:Rifampin / Q000009:adverse effects*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
D001639:Bicarbonates; D004977:Ethambutol; D003404:Creatinine; D012293:Rifampin