Mapping the gene for LTW-4, a 26,000 molecular weight major protein of mouse liver and kidney.
The polypeptide LTW-4 has previously been shown by 2D electrophoresis to be a major soluble protein of mouse liver. We now show that it is a major soluble polypeptide of mouse kidney. The Ltw-4 locus has been mapped on Chromosome 1 using the BXD, AKXL and BXH recombinant inbred strains. The gene order is Dip-1 Rnr - (Sas-1, ald) - Ltw-4 - Mls. The map distance between (Dip-1, Rnr) and Ltw-4 is estimated to be 12.2 +/- 4.2 cM, between Sas-1 and Ltw-4 5.4 +/- 2.6, between ald and Ltw-4 7.1 +/- 4.6 cM, and between Ltw-4 and Mls 4.3 +/- 2.0 cM. The strain distribution pattern of Ltw-4 is reported for the SWXL recombinant inbred strains and for a large number of inbred strains of mice.
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005796:Genes; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics; D008970:Molecular Weight; D011506:Proteins / Q000235:genetics*; D011995:Recombination, Genetic
D011506:Proteins