The studies of the mechanism of antiinflammatory action of 2-(5-ethylpyridin-2-yl)benzimidazole (KB-1043).
The mechanism of the antiinflammatory activity of 2-(5-ethylpyridin-2-ly)benzimidazole (KB-1043), a new benzimidazole derivative with antiinflammatory, analgesic and antipyretic activities, is described. KB-1043 inhibits the emigration of leucocytes and the exudation of protein into the site of injury. KB-1043 possesses also a potent membrane stabilizing activity. Although KB-1043, in vitro, did not inhibit the enzyme activity, the increase of enzyme activity at the site of injury was inhibited by the oral administration of KB-1043. The inhibitory effect of KB-1043 on prostaglandin synthesis was slightly weaker than that of acetylsalicylic acid (ASA). The antiinflammatory effect of DB-1043 was observed also in adrenalectomized rats and spinalectomized rats.
D000315:Adrenalectomy; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D002818:Cordotomy; D004285:Dogs; D004798:Enzymes / Q000378:metabolism; D005122:Exudates and Transudates / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis; D011489:Protein Denaturation; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D001562:Benzimidazoles; D004798:Enzymes; D011453:Prostaglandins; C033615:2-(5-ethylpyridin-2-yl)benzimidazole