Epidemiological and animal data as a basis for risk assessment.
The assessment of the cancer risk inherent in a chemical compound with a lengthy manufacturing history should involve the allocation of suitable weights to the various pieces of evidence. These pieces of evidence will always conflict quantitatively or even qualitatively. Data derived from animal experiments have many advantages over epidemiological material. The two major advantages of epidemiology are the relevance of the species, and the relevance of the dose to that species. The high weight to be attached to the animal data for the categorisation of carcinogens has to be severely depreciated when attempting to assess risk.
D000818:Animals; D002273:Carcinogens; D004305:Dose-Response Relationship, Drug; D004812:Epidemiologic Methods; D006801:Humans; D051381:Rats; D012306:Risk; D013045:Species Specificity
D002273:Carcinogens