[Origin of immunoglobulins bound to the surface membranes of malignant cells in non-lymphoid forms of acute human leukemia].
Anti-immunoglobulin antibody binding to the surface membrane of blast cells from patients with acute myelomono- and monoblastic leukemia has been examined. Surface receptors for IgG Fc-fragment have been demonstrated to be not responsible for anti-immunoglobulin antibody binding and blast cells not capable of intracellular synthesis of immunoglobulins. It has been shown that antigen-antibody complexes appear in the medium after a short-term cultivation of blast cells and that immunoglobulins appear in the eluates after treating the blast cells with an acid buffer. Analysis of the results indicates that immunoglobulins detectable on the surface of the blast cells in the cited forms of leukemia are antibodies to the antigens of these cells.
D002462:Cell Membrane / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007072:Immunoglobulin D / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D007948:Leukemia, Monocytic, Acute / Q000276:immunology*; D015470:Leukemia, Myeloid, Acute / Q000276:immunology*; D011961:Receptors, Fc / Q000032:analysis
D007070:Immunoglobulin A; D007072:Immunoglobulin D; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D011961:Receptors, Fc
Proiskhozhdenie immunoglobulinov, sviazannykh s poverkhnostnymi membranami zlokachestvennykh kletok pri nekotorykh nelimfoidnykh formakh ostrogo leĭkoza cheloveka.