[Morphogenesis of Gaucher's cells and cells similar to them (in myelosis)].
The cytohistological resemblance between Gaucher's cells and similar cells of the bone marrow in cases of myelosis is great but their electronoptical pictures vary,. In Gaucher's cells there are membranous limited and non-limited corpuscles, composed of typical convoluted tubules, which do not contain lipids, they may be found even in the cisterns of the rough endoplasmatic reticulum and in perinuclear cisterns. They probably represent the proteinic bearer of glucosyl-ceramids, which are extracted during standard histological techniques and therefore do not form part of the histological picture. The gradual loss of the membraneceous lining around these corpuscles is probably the expression of differently advanced states of lysosomatic break down. The Gaucherlike cells of the bone marrow are apparently macrophages with many cytolysosomes, the tubular portions of which are usually not membranous limited, do not have any tendency of screwing and they differ from the previous ones in many other details.
D001853:Bone Marrow / Q000648:ultrastructure*; D005776:Gaucher Disease / Q000473:pathology*; D006801:Humans; D007951:Leukemia, Myeloid / Q000648:ultrastructure*; D008870:Microtubules / Q000648:ultrastructure*
Morfogeneze Gaucherových bunĕk a jim podobných (pri myelóze).