Inhibition of Friend virus (FVP)-induced murine erythropoiesis with prostaglandin (PGF2 alpha): potentiation and inhibition of erythropoietin and prevention of both with PGD2.
An erythropoietin-independent virus-induced murine erythroleukemia (FVP) is used to compare the effects of an erythropoiesis inhibitory factor (EIF) isolated from human urine with the effects of prostaglandin F2 alpha. The consequent inhibition of FVP-induced erythropoiesis suggests that EIF and PGF2 alpha have similar effects on the FVP-induced erythropoiesis in mice, and the effect of PGF2 alpha is indirect. The similarity of the actions of EIF and PGF2 alpha may indicate a potential role for prostaglandins in the physiological control of some types of erythrocytosis.
D000818:Animals; D001854:Bone Marrow Cells; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005260:Female; D005622:Friend murine leukemia virus; D006400:Hematocrit; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000209:etiology; D051379:Mice; D008806:Mice, Inbred AKR; D008811:Mice, Inbred DBA; D011453:Prostaglandins / Q000494:pharmacology*; D011457:Prostaglandins D / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*
D011453:Prostaglandins; D011457:Prostaglandins D; D011460:Prostaglandins F; D004921:Erythropoietin