[Chromosome disorders in retinoblastoma cells].
The karyotype of 7 unilateral retinoblastomas was studied. Loss or a gain of chromosomes and structural chromosomal changes were observed in all tumors. Modal chromosome number was pseudodiploid in four and near-diploid in three tumors. There were no sex chromosomes (X or Y) in 3 tumors. Four tumors were characterized by the presence of an identical marker chromosome--i(6p). Two other markers--lp+ and 17q+ (probably, not quite identical)--were present in 4 and 3 tumors, respectively. The cells of two retinoblastomas contained both i (6p) and 17q+ markers.
D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000473:pathology*; D025063:Chromosome Disorders; D005134:Eye Neoplasms / Q000648:ultrastructure*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007962:Leukocytes / Q000648:ultrastructure; D008297:Male; D012175:Retinoblastoma / Q000648:ultrastructure*
D005819:Genetic Markers
Khromosomnye narusheniia v kletkakh retinoblastomy.