Genetics of Ia-like alloantigens in chickens and linkage with B major histocompatibility complex.
Two sets of backcross matings were performed to test for linkage between genes coding for the Ia-like antigens ("Ia") and the B erythrocyte antigens (Ea-B) of the chicken. Evidence is presented which indicates that the "Ia" antigens are determined by a single codominant locus and that the Ea-B and "Ia" loci are on the same chromosome. Failure to detect a single recombinant between the Ea-B and "Ia" loci out of 208 progeny suggests close linkage of the two genes with a map distance of up to about 2 centimorgans. The "Ia" genes are thus included in the B major histocompatibility complex of the chicken.
D000818:Animals; D002645:Chickens; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D008040:Genetic Linkage; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D008285:Major Histocompatibility Complex
D000949:Histocompatibility Antigens Class II