The hypereosinophilic syndrome and lymphoblastic leukemia with extra C-group chromosome and q14+ marker.
Hypereosinophilic syndrome is probably a disease of diverse etiologies. We studied the bone marrow of a patient with HES and found a population of L-1 lymphoblasts. These cells failed to grow in double-layer agar cultures, were "null cells," and contained a 14q+ marker chromosome consistent with a malignant lymphoproliferative disorder. Complete remission was induced with vincristine, prednisone, and L-asparaginase but the patient died from the consequences of cardiac fibrosis. An underlying lymphoproliferative process should be carefully sought in patients with HES to afford the best opportunity for cure.
D001215:Asparaginase / Q000627:therapeutic use; D001854:Bone Marrow Cells; D002648:Child; D002869:Chromosome Aberrations; D002906:Chromosomes, Human, 6-12 and X; D004802:Eosinophilia / Q000188:drug therapy / Q000209:etiology* / Q000401:mortality; D005260:Female; D005819:Genetic Markers; D006333:Heart Failure / Q000150:complications / Q000401:mortality; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000188:drug therapy / Q000401:mortality; D008214:Lymphocytes; D011241:Prednisone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D005819:Genetic Markers; D014750:Vincristine; D001215:Asparaginase; D011241:Prednisone