title: [Studies on absorption and excretion of cefmetazole in neonates and excretion into the bile of infants with congenital biliary atresia (author's transl)].
abstract: This is studies concerning the absorption and excretion of cefmetazole in neonates and the excretion into the bile of infants with congenital biliary atresia. 1. The concentration of cefmetazole was measured in the serum and urine of 2 neonates at the postoperative period. 2. The concentration measured in the serum showed a level similar to those of cases in pediatrics at other institutes regardless of the operation. 3. The recovery value of cefmetazole in the urine of the neonate is not different from those of other institutes even if it is a postoperative case, provided that the urine quantity is maintained. 4. Excretion of cefmetazole into the urine and bile was measured in 2 cases of congenital biliary atresia after the biliary diversion. 5. The concentration of cefmetazole in the bile of infants with congenital biliary atresia is lower than those of adults. It follows that the recovery percentage in the bile is low but the converse was true in the urine recovery. This seemed to be due to liver dysfunction that are characteristic in congenital biliary atresia. However, the concentration of cefmetazole in the bile was sufficient to obtain effective therapeutic level.
mesh_terms: D000900:Anti-Bacterial Agents / Q000097:blood / Q000378:metabolism* / Q000652:urine; D001646:Bile / Q000032:analysis; D001652:Bile Ducts / Q000002:abnormalities*; D015311:Cefmetazole; D002511:Cephalosporins / Q000378:metabolism*; D002513:Cephamycins / Q000097:blood / Q000378:metabolism* / Q000652:urine; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002513:Cephamycins; D015311:Cefmetazole