In vivo distribution of carrier protein/67Ga-complexes.
The uptake of 67Ga as citrate, chloride and complexed by carrier-proteins (lactoferrin and transferrin) has been studied in tumor- and inflammatory lesion-bearing rats. Different uptake patterns are shown by tumors and lesions. 67Ga-transferrin complexes are taken up to the highest extent by tumors and inflammatory lesions. The comparative distribution studies using normal animals indicate a systemic increase of 67Ga uptake by tumor- and lesion-bearing animals which might be of importance in explaining the mechanism of 67Ga accumulation. The role of ionic environment changes and radioactivity concentration by isomorphous ionic replacement is discussed.
D000818:Animals; D005708:Gallium; D005710:Gallium Radioisotopes; D007249:Inflammation / Q000378:metabolism; D007781:Lactoferrin / Q000378:metabolism*; D007782:Lactoglobulins / Q000378:metabolism*; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000378:metabolism*; D014018:Tissue Distribution; D014168:Transferrin / Q000378:metabolism*
D005710:Gallium Radioisotopes; D007782:Lactoglobulins; D014168:Transferrin; C034163:gallium chloride; D005708:Gallium; D007781:Lactoferrin