Toxicity to tumour cells of diethylaminoreserpine.
Diethylaminoreserpine (DL-152), an inhibitor of cyclic AMP phosphodiesterase, has been shown to kill clonogenic cells of the KHT fibrosarcoma when the drug is given intraperitoneally to the tumour-bearing mouse. DL-152 shows a greater toxicity to acutely hypoxic cells than to aerated cells. Following DL-152 injection, the number of surviving clonogenic tumour cells fell progressively until a minimum level was reached at 48 h after injection; repopulation commenced immediately and proceeded rapidly. The extent of cell killing following DL-152 injection was directly proportional to the size of the tumour at the time of treatment. A single injection of DL-152 produced no measurable change in the growth rate of small tumours. Treatment of larger tumours however, induced a period of slow growth followed by a return to the rate of growth observed in controls.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002999:Clone Cells / Q000187:drug effects; D005260:Female; D005354:Fibrosarcoma / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D012110:Reserpine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000473:pathology
C004538:bietaserpine; D012110:Reserpine