title: Search for mutations affecting protein structure in children of atomic bomb survivors: preliminary report.
abstract: A total of 289,868 locus tests, based on 28 different protein phenotypes and using one-dimensional electrophoresis to detect variant proteins, has yielded one probable mutation in the offspring of "proximally exposed" parents, who received an estimated average gonadal exposure of 31 to 39 rem in the atomic bombings of Hiroshima and Nagasaki. There were no mutations in 208,196 locus tests involving children of "distally exposed" parents, who had essentially no radiation exposure.
mesh_terms: D004307:Dose-Response Relationship, Radiation; D004798:Enzymes / Q000235:genetics; D006801:Humans; D007564:Japan; D009154:Mutation; D009689:Nuclear Warfare; D011110:Polymorphism, Genetic; D011487:Protein Conformation; D011506:Proteins / Q000235:genetics*
chemical_list: D004798:Enzymes; D011506:Proteins