Prognostic significance of amoeboid movement configuration in lymphoid cells from children with acute lymphoblastic leukaemia.
Bone marrow smears from 72 consecutive children with a recent diagnosis of acute lymphoblastic leukaemia (ALL) have been morphologically analyzed. A high incidence of lymphoid cells with amoeboid movement configuration (AMC) seems to indicate a more favorable prognosis independently of other prognostic factors e.g. age, WBC or sex. A positive correlation between the AMC and the mitotic indices (MI) of the lymphoblasts indicates some connection between the motility and the proliferative activity of the leukaemic cell clone.
D000293:Adolescent; D001853:Bone Marrow / Q000473:pathology; D001854:Bone Marrow Cells; D002465:Cell Movement; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000401:mortality / Q000473:pathology*; D007958:Leukocyte Count; D008214:Lymphocytes / Q000032:analysis*; D008297:Male; D008940:Mitotic Index