A highly specific radioimmunological determination of sulprostone (1) using antisera against two different haptens.
A sensitive and specific radioimmunoassay for sulprostone in serum has been developed. The use of antisera raised against two different haptens allows the determination of sulprostone alone or together with its main metabolites. Radioactive tracers with high specific radioactivity were synthesized by coupling the haptens to [125I]-iodohistamine.
D000818:Animals; D003429:Cross Reactions; D015232:Dinoprostone / Q000031:analogs & derivatives*; D006241:Haptens / Q000276:immunology*; D011459:Prostaglandins E, Synthetic / Q000032:analysis*; D011817:Rabbits; D011863:Radioimmunoassay / Q000379:methods; D013997:Time Factors
D006241:Haptens; D011459:Prostaglandins E, Synthetic; C016767:sulprostone; D015232:Dinoprostone