title: The prolactin-stimulating potency of reserpine in man.
abstract: The prolactin (PRL) response to 0.5 mg i.m. of reserpine was compared to 0.5 mg i.m. of haloperidol in eight young men. The fact that reserpine was found to be a potent releaser of PRL--significantly greater than haloperidol--suggests a major role of storage pool dopamine in regulating PRL Secretion. Since the PRL response to neuroleptics is highly correlated with clinical potency, reserpine could be a potent antipsychotic, and further clinical trials are indicated.
mesh_terms: D000328:Adult; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008297:Male; D011388:Prolactin / Q000097:blood*; D012110:Reserpine / Q000494:pharmacology*
chemical_list: D012110:Reserpine; D011388:Prolactin; D006220:Haloperidol