The effect of acute administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on humoral antibody production and cell-mediated activities in mice.
The effect of single doses of TCDD (1.2, 6 or 30 gamma/kg) on several immune parameters has been investigated in young adult C57B1/6 mice. TCDD profoundly suppressed the primary and secondary humoral response to T-dependent (sheep erythrocytes, SRBC) and T-independent (Type III pneumococcal polysaccharide, S III) antigens. In vitro lymphoproliferative responses to Concanavallin A (Con A) and bacterial lypopolysaccharide (LPS), and macrophage and natural killer (NK) cell-mediated cytotoxicity were not significantly affected per unit number of lymphoid cells. Moreover, the ability of splenocytes from TCDD treated animals to mediate a graft versus host (GVH) reaction was not impaired.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004147:Dioxins / Q000494:pharmacology*; D004912:Erythrocytes / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology*; D012756:Sheep / Q000276:immunology
D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins