The involvement of porphyrogenic steroids in the development of experimental porphyria.
Hexachlorobenzene alters the hepatic steroid metabolism, and it was suggested that a porphyria was induced by overproduction of 5 beta-H-steroids. Structurally similar chlorinated hydrocarbons (pentachlorobenzene, pentachlorophenol, 2,4,5-trichlorophenol) without porphyrogenic activity did not affect the steroid metabolism in rat liver.
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000378:metabolism*; D000818:Animals; D002722:Chlorobenzenes / Q000494:pharmacology*; D002733:Chlorophenols / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010088:Oxidoreductases / Q000378:metabolism*; D010416:Pentachlorophenol / Q000494:pharmacology*; D011164:Porphyrias / Q000139:chemically induced / Q000201:enzymology*; D051381:Rats; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D002722:Chlorobenzenes; D002733:Chlorophenols; C009534:2,4,5-trichlorophenol; C003060:pentachlorobenzene; D010416:Pentachlorophenol; D010088:Oxidoreductases; D015096:3-Hydroxysteroid Dehydrogenases; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase