title: [Current approaches to the combination therapy of osteogenic sarcoma].
abstract: The results of treatment of 315 cases of osteogenic sarcoma are presented. Available methods of primary tumor therapy fail to prevent dissemination of neoplastic disease by blood circulation. However, following a prophylactic course of chemotherapy (adriamycin, vincristine, cyclophosphamide, sarcolysine), 3- and 5-year survival rates in 45 cases of limb amputation for osteosarcoma increased to 38.1% and 30.5%, respectively. No recurrences were observed in 39 patients with extensive segmental resection of bone who preoperatively received intra-arterial infusions and radiation therapy; the 3-year survival rates were a high as 43.9% and patients showed good performance. The method offers good advantages in the treatment of patients with osteogenic sarcoma.
mesh_terms: D000671:Amputation, Surgical; D001859:Bone Neoplasms / Q000401:mortality / Q000628:therapy*; D004359:Drug Therapy, Combination; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D012516:Osteosarcoma / Q000401:mortality / Q000628:therapy*; D011300:Preoperative Care / Q000379:methods; D011379:Prognosis; D011879:Radiotherapy Dosage
vernacular_title: Sovremennye podkhody k kompleksnoĭ terapii osteogennoĭ sarkomy.