Plasma testosterone levels and delta 5-3 beta-hydroxysteroid dehydrogenase activity in the testis of the rat following prolonged exposure to stress.
Exposure of male CSF rats to a signalled, unpredictable 60-day stress regimen induced a significant elevation in circulating testosterone levels at Days 1 and 60 which was abolished by castration. Small morphological changes were seen in the Leydig cells in the early days of stressing. A significant increase in 3 beta-HSD activity was seen by 5 days of stress, indicating increased steroidogenic activity.
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000818:Animals; D002369:Castration; D006801:Humans; D007985:Leydig Cells / Q000648:ultrastructure; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000378:metabolism*; D013737:Testis / Q000201:enzymology* / Q000503:physiopathology / Q000648:ultrastructure; D013739:Testosterone / Q000097:blood*
D013739:Testosterone; D015096:3-Hydroxysteroid Dehydrogenases