title: Genetic studies in human and murine giardiasis.
abstract: Genetic markers were analysed in 48 adults who appeared to have a prolonged infection with Giardia lamblia. The frequency of ABO blood groups, Rhesus blood groups, and Gm phenotypes was similar to that in control subjects. However, there was a higher than expected frequency of HLA antigens A1 (observed 46 . 7%, expected 32%) and B12 (observed 47 . 8%, expected 25 . 8%) and a higher than expected frequency of the phenotypes A1/A2 and B12/B27. Genetic studies were also performed with inbred strains of mice showing relatively rapid (BALB/c) and defective (C3H/He) spontaneous elimination of Giardia muris. From analysis in backcross mice several genes appeared to influence susceptibility to prolonged infection with G. muris.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001789:Blood Group Antigens / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D005873:Giardiasis / Q000097:blood / Q000235:genetics* / Q000276:immunology; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008875:Middle Aged; D010641:Phenotype
chemical_list: D001789:Blood Group Antigens; D005819:Genetic Markers; D006680:HLA Antigens