title: GENESIS, a knowledge-based genetic engineering simulation system for representation of genetic data and experiment planning.
abstract: We have built a knowledge-based genetic engineering simulation system-- GENESIS-- capable of representing both domain-specific and general knowledge. Information is stored within a hierarchically-organized framework composed of structures called units. A series of sophisticated editors enables no-computer specialist molecular geneticists to construct a knowledge base through direct interaction with the computer. Three types of knowledge specific to the domain of molecular genetics, MAPS, sequences and RULES are discussed in detail with examples.
mesh_terms: D000818:Animals; D001482:Base Composition; D001483:Base Sequence; D003201:Computers; D004247:DNA; D005796:Genes; D005818:Genetic Engineering; D005914:Globins / Q000235:genetics; D006657:Histones / Q000235:genetics; D006801:Humans; D008722:Methods; D013045:Species Specificity
chemical_list: D006657:Histones; D005914:Globins; D004247:DNA