[Effect of lysosomal acid-soluble proteins on the respiratory activity of the granulocytes of healthy subjects and chronic myeloid leukemia patients].
A rate of oxygen consumption by granulocytes was measured before cell stimulation and following their stimulation by zymosan in healthy persons and in patients with chronic myelocytic leukemia (CML). The rate of oxygen consumption by granulocytes of donors was higher than that of patients with CML. Addition of lysosomal acid soluble proteins, extracted from normal granulocytes, affected the respiratory activity of stimulated and non-stimulated both normal and leukemic cells, depending upon the protein concentration. The alterations were more marked in granulocytes of donors. Lysosomal acid soluble proteins, extracted from granulocytes of patients with CML did not change the cell respiratory activity.
D001798:Blood Proteins / Q000494:pharmacology*; D006098:Granulocytes / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood* / Q000378:metabolism; D008247:Lysosomes / Q000032:analysis*; D009363:Neoplasm Proteins / Q000494:pharmacology*; D010101:Oxygen Consumption; D015054:Zymosan / Q000494:pharmacology
D001798:Blood Proteins; D009363:Neoplasm Proteins; D015054:Zymosan
Vliianie lizosomal'nykh kislotorastvorimykh belkov na dykhatel'nuiu aktivnost' granulotsitov zdorovykh liudeĭ i bol'nykh khronicheskim mieloleĭkozom.