Allorestriction and xenorestriction phenomena in the induction of delayed-type hypersensitivity (DTH) responses in the guinea pig against azobenzenearsonate- (ABA) modified peritoneal exudate cells.
The role of MHC products in the induction of DTH responses Ia antigens play a crucial role in these cells in the recognition of ABA determinants by lymphocytes. Second, JY-1 guinea pigs were employed as responder animals. A clear allorestriction phenomenon was observed again when weakly modified ABA-PEC were used. On the other hand, the allorestriction phenomenon was apparently abrogated when heavily modified ABA-PEC were employed: allogeneic as well as syngeneic ABA-PEC induced strong and comparable DTH responses. Even in this condition, xenogeneic (mouse) ABA-PEC were barely immunogeneic, On the basis of these observations, the cross-reactivity of Ia antigens in the conjunctive recognition of haptenic determinants by T cells is discussed.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology* / Q000276:immunology; D001391:Azo Compounds / Q000494:pharmacology*; D001667:Binding, Competitive; D006168:Guinea Pigs; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006358:Hot Temperature; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D012882:Skin Tests; D013045:Species Specificity; D010132:p-Azobenzenearsonate / Q000494:pharmacology*
D001391:Azo Compounds; D000949:Histocompatibility Antigens Class II; D010132:p-Azobenzenearsonate