title: Adjuvant combination chemotherapy for osteosarcoma.
abstract: The management of patients with osteosarcoma in Singapore has for many years been an unrewarding task for the attending physicians. Encouraged by reports of long-term survivals with adjuvant cytotoxic chemotherapy appearing in 1975, orthopaedic surgeons and radiation therapists at the Singapore General Hospital undertook a program of combination chemotherapy in moderate doses for osteosarcoma patients with localised disease treated by ablative surgery. A few who refused surgery had irradiation of the primary tumour.
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000601:surgery; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000188:drug therapy* / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents