Activity of some mixed function oxidases in prenatally carbon disulphide (CS2) treated rats.
Prenatal exposure of albino rats to carbon disulphide (CS2) at 10 and 0.03 mg/m3 led to inhibition and retardation of the development of mixed function oxidase system as shown by the prolongation of hexobarbital sleeping time in the early postnatal period. The rate of the effect was dose-dependent. The speed of recovery of the normal function of the system depended upon the rate of its initial inhibition. Hexobarbital sleeping time in the early postnatal period is suggested as a sensitive indicator of the effect of prenatal CS2 exposure.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002246:Carbon Disulfide / Q000633:toxicity*; D005260:Female; D006591:Hexobarbital / Q000494:pharmacology; D008099:Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D010088:Oxidoreductases / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D004364:Pharmaceutical Preparations; D006591:Hexobarbital; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D002246:Carbon Disulfide