Localization of an Ia-bearing glomerular cell in the mesangium.
Using trypsin to render intact, isolated rat glomeruli permeable to antibody, and using an electron microscopic immunoperoxidase technique, we have localized a phagocytic immunologically-relevant cell bearing Ia determinants to the renal mesangium. Thus there are at least two functionally distinct cell types in the renal mesangium: one is a contractile smooth musclelike cell, and the other a phagocytic cell that bears immunologically-relevant surface determinants.
D000818:Animals; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D007678:Kidney Glomerulus / Q000166:cytology / Q000276:immunology*; D008854:Microscopy, Electron; D009130:Muscle, Smooth / Q000276:immunology; D010586:Phagocytes / Q000276:immunology; D051381:Rats
D000949:Histocompatibility Antigens Class II