Acute pancreatitis in association with cytosine arabinoside therapy.
This paper reports the association of acute pancreatitis coincident with cytosine arabinoside (Ara-c) therapy in a single patient on at least two occasions. The patient had previously received L-asparaginase, but the last dose had been given 4 months prior to the onset of pancreatitis. A literature review provided two more cases of pancreatitis associated with Ara-c therapy in patients previously treated with L-asparaginase. In view of th extreme rarity of pancreatitis in patients receiving Ara-c, the possibility arises that prior treatment with L-asparaginase may predispose the pancreas to this complication.
D000208:Acute Disease; D000293:Adolescent; D000855:Anorexia / Q000139:chemically induced; D001215:Asparaginase / Q000627:therapeutic use; D003561:Cytarabine / Q000009:adverse effects*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D008297:Male; D010146:Pain / Q000139:chemically induced; D010195:Pancreatitis / Q000139:chemically induced*; D013997:Time Factors; D014463:Ultrasonography; D014839:Vomiting / Q000139:chemically induced
D003561:Cytarabine; D001215:Asparaginase