Kinetics of cell replication of the uterine cervix. IV. Proliferative loci in the basal cell layer.
The sequence of dividing and nondividing cells along the basal cell layer of the uterine cervix of C57B1 mice was investigated eight hours after vincristine injection. Of the basal cells in mitosis, 42.8% were solitary and 57.2% in groups of two or more mitoses. In contrast, 99.2% of the mitoses occurring in untreated animals were solitary, and less than 1% were double. These results suggest the existence in the basal cell layer of loci of cell production composed of multiple mitoses. The multiple mitotic loci are not observed spontaneously, due to asynchrony in cell division.
D000818:Animals; D002455:Cell Division; D002584:Cervix Uteri / Q000166:cytology*; D004971:Estrus; D005260:Female; D007399:Interphase; D007700:Kinetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008938:Mitosis; D011247:Pregnancy; D014750:Vincristine / Q000494:pharmacology
D014750:Vincristine