[Diphtheria toxin: ability to agglutinate human leukemia cells].
Human leukaemic cells were agglutinized by diphtheria toxin during an incubation of two hours. the agglutination behaved as a phenomenon of prozone. The cells grouped only in the zone with fitting proportion between toxin and cells, while no aggregation took place where lower or higher doses of toxin were used. The toxin didn't induce the agglutination of granulocytes taken from patients with acute infections diseases or taken from healthy donors. Normal lymphocytes too were not glutinated by toxin. The leucocytic agglutinability caused by toxin may be correlated to changes on the membrane induced by malagnity.
D000371:Agglutination; D004167:Diphtheria Toxin / Q000494:pharmacology*; D006098:Granulocytes / Q000187:drug effects; D006801:Humans; D007938:Leukemia / Q000097:blood*; D007945:Leukemia, Lymphoid / Q000097:blood; D007951:Leukemia, Myeloid / Q000097:blood; D007962:Leukocytes; D008214:Lymphocytes / Q000187:drug effects; D012075:Remission, Spontaneous
D004167:Diphtheria Toxin
Tossina difterica: capacità di agglutinare le cellule delle leucemia umane.