Erythrocyte choline concentrations are elevated in manic patients.
The intracellular choline concentration in erythrocytes of manic patients who never had lithium therapy was 3 times the value for normal human subjects. Lithium therapy increased this value to 11 times normal, and the increase began within the first 2 days of lithium therapy. Plasma choline concentration was normal in untreated manic patients and did not change during lithium therapy.
D000341:Affective Disorders, Psychotic / Q000097:blood*; D000818:Animals; D001714:Bipolar Disorder / Q000097:blood* / Q000188:drug therapy; D002794:Choline / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D008297:Male; D051381:Rats
D008094:Lithium; D002794:Choline