In vitro radiosensitivity of human leukemia cell lines.
The in vitro radiobiologic survival values (n, D0) of four tumor lines derived from human hematopoietic tumors were studied. These cell lines were HL50 (n = 1.3, D0 = 117 rad[1.17 Gy]), promyelocytic leukemia; K562 (n = 1.4, D0 = 165 rad[1.65 Gy]), erythroleukemia; 45 (n = 1.1, D0 = 147 rad[1.47 Gy]), acute lymphocyte leukemia; and 176 (n = 4.0, D0 = 76 rad[0.76 Gy]), acute monomyelogenous leukemia. More cell lines must be examined before the exact relationship between in vitro radiosensitivity and clinical radiocurability is firmly established.
D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D066298:In Vitro Techniques; D007938:Leukemia / Q000473:pathology*; D004915:Leukemia, Erythroblastic, Acute / Q000473:pathology; D007945:Leukemia, Lymphoid / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000473:pathology; D011836:Radiation Tolerance