title: [Cytogenetic findings in habitual abortion. Chromosomal analysis in 123 couples (author's transl)].
abstract: From the 1st of April 1974 till the 30th of September 1979 a consecutive series of 123 couples with a history of recurrent abortion was studied cytogenetically with modern banding techniques. 8 chromosomal aberrations were detected (6.5%); 3 women were found to be balanced reciprocal translocation carriers; the karyotype of 3 women and one man showed a pericentric inversion, one women was found to be a mosaic for 46 XX/45 X0. It is concluded from the results of this report that cytogenetic evaluation is indicated in cases of habitual abortion. The expected rate of chromosomal aberrations is especially high in couples with a mixed history of abortions, intrauterine fetal deaths and malformations. In case a chromosomal aberration is detected the patients have to be counselled individually according to the type of anomaly.
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D002869:Chromosome Aberrations; D005260:Female; D005313:Fetal Death; D006801:Humans; D007621:Karyotyping; D008297:Male; D011247:Pregnancy; D014178:Translocation, Genetic
vernacular_title: Zytogenetische Untersuchungen bei wiederholten Aborten. Ergebnisse von Chromosomenanalysen bei 123 Paaren.