Prophylactic treatment of the central nervous system in acute lymphoblastic leukemia. CT findings in 45 children off therapy.
45 children with ALL treated with intrathecal Methotrexate and radiation therapy, all in hematologic remission, have been examined with brain CT at intervals varying from 3 to 6 years after completion of CNS prophylaxis. Abnormalities were detected in 20% of the children; the main findings were: calcifications within the brain parenchyma in 3 patients; enlargement of the ventricular system and/or sulci in 8. The 3 patients with calcifications had seizures during or after treatment whereas those with dilatation of the ventricular system or sulci presented no neurological signs.
D000293:Adolescent; D001932:Brain Neoplasms / Q000517:prevention & control* / Q000532:radiotherapy; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007278:Injections, Spinal; D007945:Leukemia, Lymphoid / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000628:therapy*; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects; D011878:Radiotherapy / Q000009:adverse effects; D014057:Tomography, X-Ray Computed
D008727:Methotrexate