Pharmacological properties of D,L-2-phenylglycine alkylesters with special consideration of their antiinflammatory activity.
The alkylesters of D,L-2-phenylglycine are spasmolytics with antiinflammatory activity. Their efficacy could be demonstrated against carrageenan, dextran and kaolin-induced edema in rats. The investigated compounds inhibit the granuloma development after local and systemic administration. Their effectiveness is comparable with that of phenylbutazone.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D005998:Glycine