title: Prostaglandin as a mediator of bone resorption induced by experimental tooth movement in rats.
abstract: Administration of indomethacin inhibited the appearance of osteoclasts and bone resorption induced by experimental tooth movement in rats. Effects were limited to groups injected within 12 h after treatment. Prostaglandin E1 or E2 solutions injected in gingiva lying near the upper first molar caused the appearance of osteoclasts and bone resorption.
mesh_terms: D000539:Alveolar Process / Q000187:drug effects; D000818:Animals; D001862:Bone Resorption / Q000209:etiology* / Q000503:physiopathology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009967:Orthodontic Appliances / Q000009:adverse effects; D010010:Osteoclasts / Q000187:drug effects; D010510:Periodontal Diseases / Q000209:etiology; D011458:Prostaglandins E / Q000502:physiology*; D051381:Rats; D014087:Tooth Movement Techniques / Q000009:adverse effects*
chemical_list: D011458:Prostaglandins E; D007213:Indomethacin