Concentration of 5-methoxyindoles in the human pineal gland.
The pineal gland concentration of the four 5-methoxyindoles: melatonin, 5-methoxytryptamine, 5-methoxytryptophol and 5-methoxyindole-3-acetic acid, were measured by gas chromatography-mass spectrometry. The pineal glands were obtained from 11 subjects 2-3 hours post mortem. The concentration of 5-methoxytryptophol ranged from 4-93 pmoles/g, 5-methoxyindole-3-acetic acid from 79-560 pmoles/g and melatonin from 24-6860 pmoles/g. 5-methoxytryptamine was present only in trace amounts (0-12 pmoles/g). A variation over time of these compounds was not evident from the data obtained.
D008735:5-Methoxytryptamine / Q000378:metabolism*; D000368:Aged; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007210:Indoleacetic Acids / Q000378:metabolism*; D007211:Indoles / Q000378:metabolism*; D008297:Male; D008550:Melatonin / Q000378:metabolism*; D008875:Middle Aged; D010870:Pineal Gland / Q000378:metabolism*; D014363:Tryptamines / Q000378:metabolism*
D007210:Indoleacetic Acids; D007211:Indoles; D014363:Tryptamines; D008735:5-Methoxytryptamine; C030737:indoleacetic acid; C002465:methoxytryptophol; D008550:Melatonin