Serial determinations of prostaglandin E levels in amniotic fluid following the vaginal administration of a prostaglandin E2 gel.
To determine the release and absorption of prostaglandin E2 from a viscous gel instilled into the vagina for clinical purposes, serial measurements of prostaglandins E and F in amniotic fluid have been made. The results obtained suggest that the exogenous prostaglandins reach the amniotic fluid four hours after administration and following the onset of uterine stimulation. The findings are in agreement with previous clinical observations and indicate that the technique could be used to make further improvements in the prostaglandin carrier vehicles used in clinical practice.
D000653:Amniotic Fluid / Q000378:metabolism*; D015232:Dinoprostone; D005260:Female; D005782:Gels; D006801:Humans; D011247:Pregnancy; D011458:Prostaglandins E / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology*; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects; D014621:Vagina
D005782:Gels; D011458:Prostaglandins E; D015232:Dinoprostone