Stereospecific chemoattraction of lymphoblastic cells by gradients of lysophosphatidylcholine.
Human plasma contains chemoattractant activity for cultured cells from the mouse thymic lymphoma 6C3HED and also for lymphoblasts from concanavalin A-stimulated mouse spleen cells. A major portion of the attractant activity for both cell types could be attributed to plasma lysophosphatidylcholine. Studies on synthetic lysophosphatides showed that polar head group structure, acyl chain length, and stereochemical configuration are important determinants for attractant activity.
D000818:Animals; D002478:Cells, Cultured; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D008214:Lymphocytes / Q000502:physiology*; D008223:Lymphoma; D008244:Lysophosphatidylcholines / Q000494:pharmacology*; D051379:Mice; D013154:Spleen / Q000166:cytology; D013329:Structure-Activity Relationship
D008244:Lysophosphatidylcholines; D003208:Concanavalin A