Chronic myelocytic leukaemia: a pluripotent haemopoietic cell is involved in the malignant clone.
Haemopoietic cells with pluripotent capabilities, were grown in soft-gel cultures from the peripheral blood of a glucose-6-phosphate dehydrogenase (G6PD) electrophoretic A,B heterozygous female with chronic myelocytic and granulocytic progeny. Only type B isoenzyme of G6PD was found in mixed colonies, in mature neutrophils, erythrocytes, and committed granulocyte and isoenzymes of G6PD. This study provides direct evidence that a pluripotent haemopoietic stem cell is involved in the malignant clone in CML.
D000328:Adult; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005347:Fibroblasts / Q000201:enzymology; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006098:Granulocytes / Q000201:enzymology; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D007951:Leukemia, Myeloid / Q000201:enzymology / Q000473:pathology*
D007527:Isoenzymes; D005954:Glucosephosphate Dehydrogenase