title: [The effect of chemotherapy on the retention of 99mTc-methylenediphosphonate by the osteogenic sarcoma of the mouse (author's transl)].
abstract: The cytostatic action of Adriblastin on the accumulation of 99mTc-MDP by a transplantable osteogenic sarcoma in the mouse was investigated. The quantitative determination of the activity concentration in the tumor showed a concentration value 8 days after the administration of the cytostatic which was nearly twice that found in the untreated animals. This could be clearly observed in scintigrams obtained with a gamma-camera using a pinhole-collimator. The histoautoradiography likewise showed a higher concentration of the radiopharmaceutical which can be attributed to higher ossification within the tumor due to the application of the cytostatic agent. Our results indicate that scintigraphy with 99mTc-MDP is a good follow-up method during treatment with cytostatics.
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D001842:Bone and Bones / Q000378:metabolism*; D004164:Diphosphonates / Q000378:metabolism; D004317:Doxorubicin / Q000627:therapeutic use*; D051379:Mice; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011877:Radionuclide Imaging; D012513:Sarcoma, Experimental / Q000000981:diagnostic imaging / Q000188:drug therapy; D013667:Technetium / Q000378:metabolism*
chemical_list: D004164:Diphosphonates; D013667:Technetium; D004317:Doxorubicin
vernacular_title: Der Einfluss einer Chemotherapie auf die Retention von 99mTc-Methylendiphosphonat im Osteosarkom der Maus.