The choice of experimental tumour systems.
One of the commonest systems in use in cancer research today is the transplanted tumour in an inbred strain of mice. Reasons are given for suspecting that inbred mice may not be as well-defined genetically as has been supposed. The oft-quoted figure of 20 generations of brother-sister mating appears to be based on the assumption that heterozygosity at only one gene locus is involved in the foundation mating.
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D007178:Inbreeding; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000235:genetics*; D014185:Transplantation, Isogeneic