Acanthocytosis and haemolytic anaemia due to the McLeod blood group.
A fourteen-year-old boy presenting with marked acanthocytosis of the red blood cells and a compensated haemolytic anaemia was shown to have the McLeod blood type. Only three other individuals have been reported as having this abnormality of the Kell blood group system without evidence of chronic granulomatous disease. Serological typing for the McLeod phenotype should be undertaken in males with unexplained acanthocytosis, and CPK estimation may provide a screening test for this condition.
D000050:Acanthocytes; D000293:Adolescent; D000743:Anemia, Hemolytic / Q000097:blood* / Q000235:genetics; D001789:Blood Group Antigens; D003402:Creatine Kinase / Q000097:blood; D004913:Erythrocytes, Abnormal; D008040:Genetic Linkage; D006801:Humans; D007626:Kell Blood-Group System; D008297:Male; D010641:Phenotype
D001789:Blood Group Antigens; D007626:Kell Blood-Group System; D003402:Creatine Kinase