Friend murine leukemia virus resistance in Japanese wild mice: possible allelism with Fv-4 in FRG mice.
A dominant gene (Rm) for resistance to ecotropic murine leukemia virus was found in Japanese wild mice (Mn) and was similar to the FV-4 gene in inbred FRG mice. About one-fourth of the progeny of the cross (BALB/c x Mn) x (FRG x BALB/c) produced only resistant progeny when crossed to BALB/c mice, which indicated that Rm and Fv-4 are at the same chromosomal location. This evidence for allelism was confirmed by the finding that matings of BALB/c mice partially congenic for Rm or for Fv-4 yielded progeny that produced only resistant offspring when crossed to BALB/c mice.
D000483:Alleles; D000818:Animals; D003433:Crosses, Genetic; D004198:Disease Susceptibility; D005260:Female; D005622:Friend murine leukemia virus; D005796:Genes; D007942:Leukemia, Experimental / Q000235:genetics* / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008817:Mice, Mutant Strains / Q000235:genetics*; D008819:Mice, Nude