Plasma antiplasmin activities in experimental lung insufficiency.
Components of the fibrinolytic system including functional activities of plasma antiplasmins were studied in experimental lung-insufficiency in a canine model. The procedure included hemorrhagic hypotension for 2 hours and occlusion of the hepatic artery, portal vein and common bile duct for 20 minutes of the hypotensive period. Plasma levels of plasminogen decreased gradually during the experiments. Using chromogenic peptide substrate assays, significant reductions of both "immediate" and "time dependent" antiplasmin activities were observed during the first few hours of the experiments. After 4 hours, both antiplasmin activities gradually increased. In 2 of the animals studied "time dependent" antiplasmin activities were 113 and 118 per cent of initial values at 12 hours. These findings emphasize that increased antiplasmin activities may be of great importance for fibrin deposition, leading to a state of microembolism in the lung in this condition.
D000818:Animals; D004285:Dogs; D005342:Fibrinolysis; D010958:Plasminogen / Q000032:analysis; D012128:Respiratory Distress Syndrome / Q000378:metabolism*; D013997:Time Factors; D000979:alpha-2-Antiplasmin / Q000378:metabolism*
D000979:alpha-2-Antiplasmin; D010958:Plasminogen