title: Studies of retinoids in the prevention and treatment of cancer.
abstract: Investigation of retinoids for anticancer activity in humans, either in the chemopreventive or treatment mode, has been little studied. We summarize here our ongoing investigations in four different areas: (1) secondary prevention of cervical dysplasia with topical application of all-trans-retinoic acid; (2) adjuvant treatment of resected high-risk stage I and II malignant melanoma with bacille Calmette Guérin (BCG) plus or minus oral vitamin A; (3) topical vitamin A acid therapy for cutaneous metastatic melanoma; an (4) oral isotretinoin as an anticancer agent.
mesh_terms: D004224:Diterpenes; D005260:Female; D006801:Humans; D007536:Isomerism; D015474:Isotretinoin; D008545:Melanoma / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000517:prevention & control*; D010168:Palmitates / Q000627:therapeutic use; D000084562:Retinyl Esters; D012878:Skin Neoplasms / Q000188:drug therapy; D014212:Tretinoin / Q000627:therapeutic use; D002578:Uterine Cervical Dysplasia / Q000517:prevention & control; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D004224:Diterpenes; D010168:Palmitates; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate; D014212:Tretinoin; D015474:Isotretinoin