Morphometric comparison of Duchenne's muscular dystrophy and experimental bupivacaine myopathy.
The findings of this study confirm the role of the hyaline fibre in D.M.D. and support the concept of continuing necrosis with progressive failure of regeneration as the major factor in the aetiology of the pathological changes. The persistence of internal nuclei , "split" fibres and progressive fibrosis are secondary phenomenon. Comparison of the changes in D.M.D. with those seen in experimental Bupivacaine myopathy shows that the changes in the experimental myopathy are comparable to those seen in D.M.D. between the ages of 4 and 6 years. It is suggested that Bupivacaine myopathy is an acceptable animal model for D.M.D.
D000818:Animals; D001706:Biopsy; D002045:Bupivacaine / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000378:metabolism; D006801:Humans; D009132:Muscles / Q000473:pathology; D009136:Muscular Dystrophies / Q000473:pathology*; D009137:Muscular Dystrophy, Animal / Q000139:chemically induced* / Q000473:pathology; D009336:Necrosis
D003402:Creatine Kinase; D002045:Bupivacaine