Assessment of the progestagenic and oestrogenic activity of compounds by their effect on implantation in rats with diapausing embryos.
The oestrogenic, progestagenic and mixed oestrogenic--progestagenic activities of various compounds were assessed by their effects on implantation and its delay in the ovariectomized rat. Progesterone, norgestrel and 17 alpha-(2-butynyl)-17 beta-hydroxyestra-4,9,11-trien-3-one (R3852-3) were investigated. Progesterone and norgestrel proved to be progestagens with little or no inherent oestrogenic activity, while R3852-3 appeared to have both progestagenic and oestrogenic activity. The oestrogenic activity of R3852-3 was verified by using an Allen--Doisy type of assay system.
D000818:Animals; D001755:Blastocyst / Q000187:drug effects* / Q000502:physiology; D002369:Castration; D010064:Embryo Implantation / Q000187:drug effects*; D010065:Embryo Implantation, Delayed / Q000187:drug effects; D047108:Embryonic Development; D004963:Estrenes / Q000494:pharmacology*; D005260:Female; D009644:Norgestrel / Q000494:pharmacology*; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats
D004963:Estrenes; C029673:17-alpha-(2-butynyl)-17 beta-hydroxyestra-4,9,11-trien-3-one; D009644:Norgestrel; D011374:Progesterone