title: Systemic availability of ergotamine tartrate in continuous medication.
abstract: There seems to be great individual differences in the bioavailability of ergotamine in continuous use. The great tolerance to ergotamine in some patients using the drug on a daily basis, even in high doses, may be due to the low-bioavailability of ergotamine in these subjects. This may also explain the infrequency of serious complications among migraine patients.
mesh_terms: D000328:Adult; D001682:Biological Availability; D004878:Ergotamine / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy
chemical_list: D004878:Ergotamine