Comparative studies on cardiotoxicity of some anthracycline antitumor antibiotics.
Isolated atria of guinea-pigs showed negative inotropic and negative chronotropic responses after violamycin B I (V), carminomycin (C) and daunomycin (D), respectively. The mean effective concentrations in reducing amplitude (IC50) were 5.9 x 10(-4) mol x 1(-1) for V and 1.3 x 10(-4) mol x 1(-1) for C and D. In rabbits, intravenous injections of different doses of the antibiotics twice weekly for one month produced histopathological alterations in the myocardial tissue, which were smaller after D than after C or V.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000633:toxicity*; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D006331:Heart Diseases / Q000139:chemically induced*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D009200:Myocardial Contraction / Q000187:drug effects
D000903:Antibiotics, Antineoplastic