Opposition of the vasopressin-induced vasoconstriction in the isolated perfused rat kidney by some prostaglandins.
PGE2 can vasoconstrict or vasodilate the isolated Krebs-perfused rat kidney depending on the tone of the renal vasculature. Thus, it is weakly constrictor (thres-hold 5-10 ng bolus dose) in the perfused kidney whose perfusion pressure is 47 +/- 2 SD mmHg (n = 6), but becomes a vasodilator (threshold approximately 10 pg) in the kidney whose perfusion pressure has been raised to 73 +/- 6 SD mmHg (n = 6) or 121 +/- 8 SD mmHg (n = 6) through constant infusion of Vasopressin (0.1 and 0.25 mU/ml respectively. PGE1 was equally effective as PGE2 while other PGs, I2, I1, and 6-keto E1, were less effective in opposing vasoconstriction. PGF2 alpha was inactive up to a dose of 10 ng.
D000818:Animals; D015232:Dinoprostone; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000098:blood supply*; D008297:Male; D011453:Prostaglandins / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects*; D014661:Vasoconstriction / Q000187:drug effects*; D014667:Vasopressins / Q000494:pharmacology*
D011453:Prostaglandins; D011458:Prostaglandins E; D014667:Vasopressins; D015232:Dinoprostone