Estradiol dehydrogenase activity in the Fallopian tube during the normal menstrual cycle.
Simultaneous determinations of 17 beta-estradiol dehydrogenase activity (17 beta-HSDH) and of estradiol (E2), estrone (E1), and progesterone (P) were made in homogenates of human tubal tissue. The oviducts were obtained from 16 multi-parous normal women who requested sterilization; surgery was performed at different phases of the menstrual cycle. A significant decrease of E2 concentration with a concomitant increase of E1 was observed in the secretory phase of the cycle. The activity of 17 beta-HSDH was highest in the early secretory phase of the cycle with a significant difference (p less than 0.05) from the proliferative phase values. The results support the concept, that the activity of 17 beta-HSDH in the oviduct is regulated by progesterone.
D015067:17-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000328:Adult; D004958:Estradiol / Q000378:metabolism; D004960:Estradiol Dehydrogenases / Q000378:metabolism*; D004970:Estrone / Q000378:metabolism; D005187:Fallopian Tubes / Q000201:enzymology*; D005260:Female; D005498:Follicular Phase; D006801:Humans; D008183:Luteal Phase; D008598:Menstruation; D011374:Progesterone / Q000378:metabolism
D004970:Estrone; D011374:Progesterone; D004958:Estradiol; D015067:17-Hydroxysteroid Dehydrogenases; D004960:Estradiol Dehydrogenases