title: Cellular response to orthodontic force.
abstract: Orthodontic force systems, by way of stress/strain, are transduced to a biologic signal that affects a multifaceted bone remodeling response. Tooth movement involves not only a periodontal ligament response (alveolus translocation), but also bursts of resorption associated with truncated remodeling events in the path of the advancing tooth. Osteoclasts are recruited primarily from the macrophage/monocyte series, whereas osteoblasts are produced by local periodontal ligament cell proliferation and differentiation. Based on nuclear size, periodontal cells are a multicompartmental population. The relatively large nuclei (D fraction) are the immediate precursors of osteoblasts, and the cells with small nuclei (A fraction are apparently the undifferentiated, germinal compartment.
mesh_terms: D000539:Alveolar Process / Q000166:cytology* / Q000502:physiology; D001862:Bone Resorption / Q000503:physiopathology; D006801:Humans; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D010012:Osteogenesis; D010513:Periodontal Ligament / Q000502:physiology; D013314:Stress, Mechanical; D014087:Tooth Movement Techniques