Antagonism by PGE2 of the vasoconstriction induced by PGF2 alpha in human ovary in vitro.
Human ovaries from adnexectomy were perfused via the ovarian artery with constant volume of Thyrode's solution. Perfusion pressure was recorded while doses of PGF2 alpha or PGF2 (2.5, 5 or 10 microgram/min) were infused for 10 min. During the 10-min infusion period an increase in perfusion pressure (delta mm Hg) was observed in proportion to the doses of PGF2 alpha. PGE2 in 2.5- or 5-microgram/min doses were ineffective, but its 10-microgram/min dose increase the perfusion pressure. However, PGE2 (4 microgram/min) infused continuously into the ovary inhibited the vasoconstriction induced by PGF2 alpha, whereas the vasoconstrictor effect of noradrenaline remained unchanged.
D000328:Adult; D015237:Dinoprost; D015232:Dinoprostone; D005260:Female; D006801:Humans; D008875:Middle Aged; D009638:Norepinephrine / Q000494:pharmacology; D010053:Ovary / Q000098:blood supply*; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects*
D011458:Prostaglandins E; D011460:Prostaglandins F; D015237:Dinoprost; D015232:Dinoprostone; D009638:Norepinephrine