An evaluation of the analgesic efficacy of three opioid-analgesic combinations in postoperative oral surgery pain.
The analgesic efficacy of a hydrocodone-acetaminophen combination, a codeine-acetaminophen combination, a codeine-APC (aspirin, phenacetin, and caffeine) combination, and a placebo was evaluated in outpatients who had moderate or severe pain after the surgical removal of impacted third molars. Each of the active medications had a significant effect on essentially all measures of total and peak analgesia; they did not differ significantly on any measure of analgesia. Adverse effects were transitory and, in general, appear to have been related to the centrally acting component of each combination analgesic.
D000082:Acetaminophen / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000700:Analgesics / Q000009:adverse effects / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use; D003061:Codeine / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006853:Hydrocodone / Q000627:therapeutic use; D008297:Male; D008963:Molar / Q000601:surgery; D010149:Postoperative Pain / Q000188:drug therapy*; D010615:Phenacetin / Q000627:therapeutic use
D000700:Analgesics; D004338:Drug Combinations; D000082:Acetaminophen; D006853:Hydrocodone; D010615:Phenacetin; D001241:Aspirin; D003061:Codeine