Glycosaminoglycans of brain tumors transplacentally induced by ENU in the rat.
GAGs accumulate in the oligodendrogliomas and in the oligodendroglial component of mixed gliomas induced in rats by transplacental ENU. We studied the period between birth and the appearance of the earliest tumoral lesions and did not find any accumulation preceding the early neoplastic proliferations. These findings, together with the observation that GAGs are present only in the oligodendroglial component of tumors, are in agreement with our previous interpretation that the tumoral transformation of oligodendroglia takes place after it has acquired the ability to interfere with GAG metabolism during myelinogenesis.
D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced* / Q000378:metabolism; D005038:Ethylnitrosourea / Q000494:pharmacology*; D005260:Female; D005910:Glioma / Q000139:chemically induced* / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D009836:Oligodendroglia / Q000378:metabolism; D009837:Oligodendroglioma / Q000139:chemically induced* / Q000378:metabolism; D011247:Pregnancy; D051381:Rats
D006025:Glycosaminoglycans; D009607:Nitrosourea Compounds; D005038:Ethylnitrosourea