Urinary prostaglandins, vasopressin, and kallikrein excretion in healthy children from birth to adolescence.
The urinary excretion of PGE2, PGF2 alpha, arginine-vasopressin, and kallikrein was measured in 58 healthy subjects aged 2 days to 13 years. In contrast to the activity of the renin-angiotensin-aldosterone system, which is known to decrease from birth, urinary excretion of PGE2, PGF2 alpha, vasopressin, and kallikrein significantly increased with age. These changes were not correlated to urine volume, natruresis, or glomerular filtration rate. Correction of the values by body surface area obliterated the differences for PGs and vasopressin, but not for kallikrein.
D000293:Adolescent; D000328:Adult; D000375:Aging; D001127:Arginine Vasopressin / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D015237:Dinoprost; D015232:Dinoprostone; D004231:Diuresis; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007610:Kallikreins / Q000652:urine*; D008297:Male; D011453:Prostaglandins / Q000652:urine*; D011458:Prostaglandins E / Q000652:urine; D011460:Prostaglandins F / Q000652:urine
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D001127:Arginine Vasopressin; D015237:Dinoprost; D007610:Kallikreins; D015232:Dinoprostone