Vitamin K deficiency developing in patients with renal failure treated with cephalosporin antibiotics.
Five patients developed vitamin K-related abnormalities in blood coagulation during treatment with parenteral cephalosporin or cephamycin antibiotics. All the patients had significantly impaired renal function and complicated medical problems. The coagulation defect was corrected with vitamin K therapy.
D000328:Adult; D000368:Aged; D002511:Cephalosporins / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000150:complications*; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000188:drug therapy; D014552:Urinary Tract Infections / Q000188:drug therapy; D014812:Vitamin K / Q000627:therapeutic use; D014813:Vitamin K Deficiency / Q000139:chemically induced*
D002511:Cephalosporins; D014812:Vitamin K