[Prenatal diagnosis of genetic disorders by linkage analysis (author's transl)].
Most of the well-known monogenic disorders to date cannot be diagnosed prenatally. In principle, this problem can be overcome indirectly if the gene in question is linked to a cytogenetic, biochemical, or molecular polymorphism. In this respect, the last-mentioned will gain increasing importance in prenatal diagnosis in the near future. The problems of such linkage studies in X-linked, autosomal dominant, and recessive disorders are discussed. Prenatal diagnosis, monogenic disorders, linkage group analysis, chromosomal polymorphisms, DNA-sequence polymorphisms.
D000328:Adult; D000653:Amniotic Fluid / Q000166:cytology; D002869:Chromosome Aberrations / Q000175:diagnosis; D025063:Chromosome Disorders; D005260:Female; D005799:Genes, Dominant; D005808:Genes, Recessive; D030342:Genetic Diseases, Inborn / Q000175:diagnosis*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D007223:Infant; D008297:Male; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*
D005819:Genetic Markers
Pränatale Diagnose von Erbleiden durch Koppelungsanalysen.