title: The relative efficacy of indoprofen compared with opioid-analgesic combinations.
abstract: This double-blind, parallel-design study used postsurgical dental outpatients as subjects. The patients self-administered a single dose of one of the study medications when they estimated their pain to be of moderate or severe intensity. The study medications were 200 mg of indoprofen, 650 mg of acetaminophen, 650 of acetaminophen with 60 mg of codeine, 650 mg of acetaminophen with 100 mg of d-propoxyphene N, and a placebo. On a report form, data were recorded on baseline pain and then hourly for four hours, intensity of pain, relief of pain, and side effects were reported. Also, an overall evaluation was recorded. Data were analyzed with the use of analysis of variance and Duncan's Multiple Range test. All four active treatments were statistically superior to placebo for sum pain intensity difference, total relief of pain, and overall evaluation parameters. Both opioid-analgesic combinations showed small additive effects over acetaminophen alone, and indoprofen was superior to both combination treatments and acetaminophen alone.
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage*; D000328:Adult; D003061:Codeine / Q000008:administration & dosage*; D011431:Dextropropoxyphene / Q000008:administration & dosage*; D004311:Double-Blind Method; D004338:Drug Combinations; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007216:Indoprofen / Q000627:therapeutic use*; D008297:Male; D010149:Postoperative Pain / Q000517:prevention & control*; D010666:Phenylpropionates / Q000627:therapeutic use*; D014081:Tooth Extraction / Q000009:adverse effects
chemical_list: D004338:Drug Combinations; D010666:Phenylpropionates; D000082:Acetaminophen; D007216:Indoprofen; D011431:Dextropropoxyphene; D003061:Codeine