title: Endotoxic activity in periapical lesions.
abstract: Thirty tissue samples were examined histologically and classified as being inflamed (apical granulomas) or noninflamed (scars or noninflamed cysts). The samples were then homogenized in pyrogen-free water and treated to remove interfering substances. The presence of endotoxin was then determined by means of the limulus assay; 75 percent of the inflamed tissues were positive for endotoxin, while only 20 percent of the noninflamed tissues contained endotoxin. The presence of endotoxin was thus highly correlated (p = 0.015) with the presence of inflammation in these tissues.
mesh_terms: D004731:Endotoxins / Q000009:adverse effects / Q000378:metabolism*; D006801:Humans; D008033:Limulus Test; D010484:Periapical Granuloma / Q000209:etiology / Q000378:metabolism* / Q000473:pathology
chemical_list: D004731:Endotoxins