Tolerability of ibuprofen and flurbiprofen in G-6-PD deficient subjects: in vitro study.
1 A 'GSH (reduced glutathione) stability test' which consists of incubating blood samples with acetylphenylhydrazine and other test drugs and measuring GSH level before and after incubation, was carried out. 2 Application of this test to the blood of eight normal volunteers and twelve known G-6-PD deficient persons demonstrated that acetylphenylhydrazine and primaquine produced a significant decrease in GSH levels in G-6-PD deficient red cells compared to the reduction seen in normal red cells incubated with these drugs. No such change was observed with aspirin, ibuprofen and flurbiprofen. 3 The results of this in vitro study seem to indicate that ibuprofen and flurbiprofen are relatively innocuous in G-6-PD deficient individuals.
D004912:Erythrocytes / Q000187:drug effects*; D005260:Female; D005480:Flurbiprofen / Q000494:pharmacology*; D005978:Glutathione / Q000097:blood; D005953:Glycogen Storage Disease Type I / Q000097:blood*; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology*; D008297:Male; D011422:Propionates / Q000494:pharmacology*
D011422:Propionates; D005480:Flurbiprofen; D005978:Glutathione; D007052:Ibuprofen