Ornithine decarboxylase as a monitor for luteal stimuli in the pregnant rat.
The sustained elevation during Days 12--21 of pregnancy of rat luteal ornithine decarboxylase, which is inducible experimentally by hCG and PGF-2 alpha, was dependent upon intact placentae and oestrogen, but independent of prostaglandin, and was absent at corresponding times of pseudopregnancy. It is suggested that his enzyme activity is a response to an hCG-like hormone of placental origin. Two brief reappearances of enzyme activity on Days 21 and 22 of pregnancy, dependent upon intact placentae and upon both oestrogen and prostaglandin, suggest a pulsatile release of PGF-2 alpha from the uterus or placentae. These experiments illustrate the value of ornithine decarboxylase in seeking unknown hormonal influences upon the corpus luteum.
D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism*; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D003338:Corpus Luteum / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D015237:Dinoprost; D004790:Enzyme Induction / Q000187:drug effects; D004967:Estrogens / Q000502:physiology; D005260:Female; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D010920:Placenta / Q000502:physiology; D011247:Pregnancy; D011460:Prostaglandins F / Q000494:pharmacology; D011555:Pseudopregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D006063:Chorionic Gonadotropin; D004967:Estrogens; D011460:Prostaglandins F; D015237:Dinoprost; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase