Stability of N-formimidoylthienamycin in aqueous solution.
The stability of N-formimidoylthienamycin in aqueous solution at 25 and 40 degrees was determined. In pH 5-8 nonnucleophilic inert buffers, pseudo-first-order ring opening was observed with dilute solutions (1 or 2 mg/ml initially). At higher initial concentrations, a second-order reaction also was evident. The rate data were compared with literature data for various cephalosporins and penicillins.
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D015378:Imipenem; D007700:Kinetics; D007769:Lactams; D010406:Penicillins; D010710:Phosphates; D012996:Solutions
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D007769:Lactams; D010406:Penicillins; D010710:Phosphates; D012996:Solutions; D015378:Imipenem