Effect of prostaglandins F2alpha and E1 on local tissue Po2 and microflow of the brain cortex (cat).
The effects of prostaglandin F2 alpha (PGF2 alpha) and E1 (PGE1) on local tissue Po2 and microflow in the cat's brain surface were studied. Local tissue Po2 was polarographically measured with a multiwire surface electrode, and microflow measured by local hydrogen clearance method. The PGs were investigated by intracarotid (i.c.) infusions, single i.c. and intravenous (i.v.) injections. The i.c. infusions were made with dose of 3, 10 and 30 microgram/kg/min of PGF2 alpha and 0.1, 0.4 and 1.0 microgram/kg/min of PGE1. The i.c. application of PGF2 alpha led to a decrease in local tissue Po2 and tissue microflow. With the use of comparatively low doses (3 and 10 microgram) the effect appeared to be more specific, since SAP did not change significantly. Systemic (i.v.) injections of PGF2 alpha caused a significant drop in arterial pressure and decrease in tissue Po2. Studies with PGE1 always demonstrated a decrease in local tissue Po2 and microflow associated with a significant decrease in the SAP. No evidence for a specific effect was found. Suggestions for possible mechanism of action for these PGs are made.
D000527:Alprostadil; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002339:Carotid Arteries; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D015237:Dinoprost; D007261:Infusions, Intra-Arterial; D007269:Injections, Intra-Arterial; D008833:Microcirculation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology*; D011460:Prostaglandins F / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D011458:Prostaglandins E; D011460:Prostaglandins F; D015237:Dinoprost; D000527:Alprostadil