The fate of propoxur in rat.
The dynamics of absorption, distribution, biotransformation, and excretion of propoxur in rat was studied. The animals were given single doses of propoxur: a) 5 mg/kg intravenously (i.v.), b) 5 mg/kg 14-C labelled compound (1.5 muCi) intravenously, c) 50 mg/kg orally. The concentrations of propoxur and its metabolite 2-isopropoxyphenol were determined in blood, liver, kidneys, brain and urine. Pharmacokinetic data concerning absorption, distribution and excretion were calculated.
D000284:Administration, Oral; D000818:Animals; D001711:Biotransformation; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D001074:Propoxur / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D014018:Tissue Distribution
D001074:Propoxur