Hypothetical mechanism of therapeutic synergism induced by the combination of 6-thioguanine and 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001973:Bromodeoxyuridine / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D007939:Leukemia L1210 / Q000188:drug therapy*; D008727:Methotrexate / Q000627:therapeutic use; D051379:Mice; D008815:Mice, Inbred Strains; D015376:Nimustine; D009607:Nitrosourea Compounds / Q000627:therapeutic use*; D013866:Thioguanine / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D009607:Nitrosourea Compounds; D015376:Nimustine; D013866:Thioguanine; D001973:Bromodeoxyuridine; D005472:Fluorouracil; D008727:Methotrexate