Long-term survival of normal adult human tissues as xenografts in congenitally athymic nude mice.
Bronchi, pancreatic ducts, and colons from adult human were maintained as xenografts in congenitally athymic nude N:NIH(S) mice for 715, 145, and 89 days, respectively. After an ischemic crisis and revascularization of the human tissue, the epithelium regenerated to a normal differentiated morphology. The long-term survival of normal adult human epithelial tissues as xenografts provides model systems for the study of the interactions of chemical and/or physical carcinogens with human tissues.
D000818:Animals; D001980:Bronchi / Q000276:immunology* / Q000473:pathology / Q000637:transplantation; D002273:Carcinogens; D003106:Colon / Q000276:immunology* / Q000473:pathology / Q000637:transplantation; D004195:Disease Models, Animal; D006085:Graft Survival; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009369:Neoplasms / Q000139:chemically induced; D010183:Pancreatic Ducts / Q000276:immunology* / Q000473:pathology / Q000637:transplantation; D010865:Pilot Projects; D013997:Time Factors; D014183:Transplantation, Heterologous
D002273:Carcinogens