Prediction of the efficacy of hemoperfusion and hemodialysis in severe poisoning.
The pharmacokinetics of nine drugs were studied in 13 severely intoxicated patients treated with combined hemoperfusion-hemodialysis. Five drugs (phenobarbital, methylphenobarbital, amobarbital, meprobamate, thallium) showed one-compartment kinetics. For two drugs (secobarbital, methaqualone) however a two-compartment model had to be accepted. For the former group a one-compartment linear model can be used to predict the efficacy of treatment and to calculate the optimal duration of treatment.
D006464:Hemoperfusion; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D011041:Poisoning / Q000628:therapy*; D006435:Renal Dialysis