Blood platelet 5-hydroxytryptamine accumulation and migraine.
The active uptake of 5-hydroxytryptamine (5-HT) by platelets from migraine patients was measured and the results compared with 5-HT uptake of platelets from normal subjects. No significant differences in platelet 5-HT uptake were found between migraine patients and control subjects. A significant correlation was found between the length of time since the patients last migraine attack and Vmax (maximal rate of 5-HT transport). Patients who had a headache within five days prior to the test had significantly lower values of Vmax than patients without recent headaches. The implications and possible causes of this reduction in platelet 5-HT transport are discussed.
D000328:Adult; D000367:Age Factors; D001792:Blood Platelets / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000097:blood*; D011188:Potassium / Q000097:blood; D012701:Serotonin / Q000097:blood*; D012964:Sodium / Q000097:blood; D013997:Time Factors
D012701:Serotonin; D012964:Sodium; D011188:Potassium