Genetical studies of low plasma alkaline phosphatase (ALP) activity in the IS strain of rats.
The low plasma alkaline phosphatase (ALP) activity of the IS strain of rats was genetically analyzed by using the cross matings with the BN strain. In the F1 hybrids, the ALP activities were intermediate but largely biased to the low activity. In the (F1 x BN) back-cross progeny, the distributions of plasma ALP activities were apparently bimodal in both sexes. Alp-2 locus with two alleles of Alp-2h and Alp-2l is tentatively proposed. Alp-2 locus did not link to the rat linkage group (LG) I, II, IV, V, and LGs containing Amy-1 and Cs-1. In the (F1 x IS) back-cross progeny, the plasma ALP activities were not different from that of the F1 hybrids and the distribution was not bimodal. Alp-2l may be dominant over Alp-2h. One third of the back-cross progeny showed vertebral anomalies and the difference of plasma ALP activities was not detected between the rats with and without vertebral anomalies.
D000469:Alkaline Phosphatase / Q000097:blood*; D000818:Animals; D005260:Female; D005819:Genetic Markers; D006824:Hybridization, Genetic; D007014:Hypophosphatasia / Q000235:genetics*; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D011919:Rats, Inbred Strains / Q000235:genetics*; D013131:Spine / Q000002:abnormalities
D005819:Genetic Markers; D000469:Alkaline Phosphatase