Indomethacin enhancement of human natural killer cytotoxicity to herpes simplex virus infected cells in vitro and in vivo.
Indomethacin, a prostaglandin synthetase inhibitor, increased human mononuclear cell (MC) natural killer cytotoxicity (NKC) to herpes simplex virus (HSV) infected cells in vitro at concentrations of 2 X 10(-10)M (p less than .025). Infant mice were significantly (p less than 0.025) protected from a lethal HSV infection by prior injection with a combination of MC and indomethacin (60.7% survival) although neither alone was protective. These results further support the probable in vivo role of NKC in protection against HSV infection, and the critical regulation of NKC by prostaglandins.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects*; D005260:Female; D006561:Herpes Simplex / Q000276:immunology*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D009000:Monocytes / Q000187:drug effects / Q000276:immunology
D007213:Indomethacin