Abnormalities in the macroscopically normal white matter in cases of mild or spinal multiple sclerosis (MS).
In a study of a series of mild and spinal varieties of multiple sclerosis the following histological changes have been found in the macroscopically normal white matter: 1. Marked astrocytic proliferation. 2. Some sclerosis of blood vessels. 3. Some perivascular inflammation. 4. Occasional unsuspected demyelination.
D000368:Aged; D001921:Brain / Q000473:pathology; D005260:Female; D005911:Gliosis / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology*; D009186:Myelin Sheath / Q000648:ultrastructure; D013116:Spinal Cord / Q000473:pathology