title: X-linked steroid sulfatase: evidence for different gene-dosage in males and females.
abstract: Steroid sulfatase (STS) activities in female fibroblast strains are significantly higher than in male strains, as determined by cleavage of dehydroepiandrosterone sulfate. The difference is probably not due to hormonal control of gene expression, but suggests that for this X-linked locus there is no gene dosage compensation.
mesh_terms: D000483:Alleles; D005260:Female; D005347:Fibroblasts; D008040:Genetic Linkage; D006801:Humans; D007057:Ichthyosis / Q000235:genetics; D066298:In Vitro Techniques; D008214:Lymphocytes; D008297:Male; D012730:Sex Chromosomes; D043266:Steryl-Sulfatase; D013429:Sulfatases / Q000235:genetics*; D014960:X Chromosome
chemical_list: D013429:Sulfatases; D043266:Steryl-Sulfatase