title: [Role of 24,25-dihydroxycholecalciferol in bone mineralization under hypokinesia in the rat].
abstract: 24,25-Dihydroxycholecalciferol, an active D3 vitamin metabolite, at a dose of 1.25 microgram/day/animal prevents bone osteoporotic changes, effectively stimulating the diaphyseal and epiphyseal mineralization, and corrects hypocalcemia of hypokinetic rats. 24,25(OH)2D3 at the above dose does not increase nephrocalcinosis or does not produce the toxic effect as measured by body mass variations.
mesh_terms: D015650:24,25-Dihydroxyvitamin D 3; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D004100:Dihydroxycholecalciferols / Q000494:pharmacology*; D005269:Femur / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008297:Male; D010758:Phosphorus / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013997:Time Factors
chemical_list: D004100:Dihydroxycholecalciferols; D010758:Phosphorus; D015650:24,25-Dihydroxyvitamin D 3; D002118:Calcium
vernacular_title: Rol' 24,25-dioksikholekal'tsiferola v mineralizatsii kostnoĭ tkani krys pri gipokinezii.