TNP-coupled membranes stimulate T cell proliferation via the macrophage.
TNP-coupled membranes derived from guinea pig m phi were capable of inducing both primary and secondary antigen-specific T cell proliferative responses; however, effective stimulation by hapten-coupled membranes required the presence of unmodified m phi. A genetic analysis demonstrated that the Ia antigens of the unmodified m phi rather than the Ia antigens borne on the TNP-coupled membranes determined the histocompatibility restrictions on m phi T cell interaction.
D000818:Animals; D002455:Cell Division; D002462:Cell Membrane / Q000276:immunology; D006168:Guinea Pigs; D006649:Histocompatibility Antigens; D008264:Macrophages / Q000276:immunology*; D009578:Nitrobenzenes / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology*; D014301:Trinitrobenzenes / Q000276:immunology*
D006649:Histocompatibility Antigens; D009578:Nitrobenzenes; D014301:Trinitrobenzenes