title: Conformational and functional changes in the fourth component of human complement produced by nucleophilic modification and by proteolysis with C1s-.
mesh_terms: D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000097:blood; D002942:Circular Dichroism; D003166:Complement Activating Enzymes / Q000378:metabolism; D003173:Complement C1s; D003181:Complement C4 / Q000378:metabolism*; D006461:Hemolysis; D006801:Humans; D006834:Hydrazines / Q000494:pharmacology; D016167:Integrin alphaXbeta2; D007700:Kinetics; D008744:Methylamines / Q000494:pharmacology; D011487:Protein Conformation; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
chemical_list: D002352:Carrier Proteins; D003181:Complement C4; D006834:Hydrazines; D016167:Integrin alphaXbeta2; D008744:Methylamines; D003166:Complement Activating Enzymes; D003173:Complement C1s