Treatment of urinary infections with cefadroxil: controlled comparison of high-compliance oral dosage regimens.
The efficacy and tolerability of cefadroxil were assessed in a controlled comparison of high-compliance oral dosage regimens among 100 patients with urinary tract infections. Each patient was randomly assigned to one of three cefadroxil treatment groups: 2,000 mg. once daily, 1,000 mg. once daily, or 1,000 mg. twice daily. Urine cultures at five to nine days post-treatment revealed cures in 27 of 36 patients in the 2,000-mg. daily group, 32 of 36 patients in the 1,000-mg. daily group, and 27 of 28 patients taking 1,000 mg. twice daily. Recurrence rates were extremely low in all treatment groups, and only 3 patients had evidence of limited side effects. The benefits of a convenient and readily understood dosage schedule are discussed.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage* / Q000009:adverse effects; D002511:Cephalosporins / Q000008:administration & dosage* / Q000009:adverse effects; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011897:Random Allocation; D014552:Urinary Tract Infections / Q000188:drug therapy*
D000892:Anti-Infective Agents, Urinary; D002511:Cephalosporins