Drug-induced liver disease in Denmark. An analysis of 572 cases of hepatotoxicity reported to the Danish Board of Adverse Reactions to Drugs.
During the decade 1968-1978 the Danish Board of Adverse Reactions to Drugs received 572 (6% of the total number) reports on hepatotoxicity. Halothane amounted to one fourth of the reported cases. Among the 94 psychotropic-induced adverse drug reactions 54 cases were attributed to chlorpromazine, 10 to tricyclic antidepressants, and only 2 to benzodiazepines. Considering the drug consumption data, the combination trimethoprim-sulfamethoxazole is nearly five times more frequently associated with hepatotoxicity than administration of sulfamethizole. Almost two thirds of the hepatotoxic reactions were classified as cytotoxic. Halothane, oxyphenisatin, rifampicin, alfa-methyldopa, papaverine, phenytoin, and ajmaline were almost exclusively related to cytotoxic reactions. Excluding the halothane-induced hepatotoxic reactions, the relative mortality of the cytotoxic (6%) reactions is not significantly different from that of the cholestatic (3%) ones. Thirteen percent of the patients with halothane-induced hepatotoxicity died.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects; D000995:Antitubercular Agents / Q000009:adverse effects; D001569:Benzodiazepines / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology*; D002648:Child; D002746:Chlorpromazine / Q000009:adverse effects; D003276:Contraceptives, Oral / Q000009:adverse effects; D003718:Denmark; D004338:Drug Combinations / Q000009:adverse effects; D005260:Female; D006221:Halothane / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010114:Oxyphenisatin Acetate / Q000009:adverse effects; D012308:Risk Management; D013420:Sulfamethoxazole / Q000009:adverse effects; D014295:Trimethoprim / Q000009:adverse effects; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D000892:Anti-Infective Agents, Urinary; D000929:Antidepressive Agents, Tricyclic; D000995:Antitubercular Agents; D003276:Contraceptives, Oral; D004338:Drug Combinations; D001569:Benzodiazepines; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole; D010114:Oxyphenisatin Acetate; D002746:Chlorpromazine; D006221:Halothane