Loss of immune competence with age may be due to auto-anti-idiotypic antibody regulation.
D000375:Aging; D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000917:Antibody Formation; D001323:Autoantibodies; D001402:B-Lymphocytes / Q000276:immunology*; D007108:Immune Tolerance; D007130:Immunoglobulin Idiotypes; D008297:Male; D051379:Mice; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D013154:Spleen / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D007130:Immunoglobulin Idiotypes; D011947:Receptors, Antigen, B-Cell