DNA repair synthesis in subpopulations of human lymphocytes.
Human peripheral blood lymphocytes enriched in T or B cells were exposed to ultraviolet irradiation, nitrogen mustard or methylmethane sulphonate and investigated regarding their capacity for DNA repair synthesis. The DNA repair synthesis, measured as [3H] thymidine incorporated, was determined by autoradiography as unscheduled DNA synthesis (UDS). No systematic difference could be found in the capacity for UDS between the T- and B-cell-enriched fractions. A larger individual variation in UDS was found in the B-cell- compared to the T-cell-enriched lymphocytes.
D001402:B-Lymphocytes / Q000378:metabolism*; D002478:Cells, Cultured; D004260:DNA Repair; D006801:Humans; D006918:Hydroxyurea / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D008466:Mechlorethamine / Q000494:pharmacology; D008741:Methyl Methanesulfonate / Q000494:pharmacology; D013601:T-Lymphocytes / Q000378:metabolism*; D014466:Ultraviolet Rays
D008466:Mechlorethamine; D008741:Methyl Methanesulfonate; D006918:Hydroxyurea