title: [Anti-hypertensive action of Captopril. Hemodynamic study (author's transl)].
abstract: Hemodynamic parameters were studied before and after administration of SQ 14 225, an orally active converting enzyme inhibitor, in 6 sustained essential hypertensive patients. Blood pressure and total peripheral resistance significantly decreased while cardiac output and heart rate remained unchanged. Systolic time intervals and plasma volume were not modified. No correlation was observed between the basal value of plasma renin activity and the decrease in blood pressure. The study demonstrated the vasodilatator effect of SQ 14 225 and questionned the role of the renin-angiotensin system in the mechanism of the pressure decrease.
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D010953:Plasma Volume / Q000187:drug effects; D011392:Proline / Q000031:analogs & derivatives*; D012083:Renin / Q000097:blood; D013599:Systole / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents; D011392:Proline; D002216:Captopril; D012083:Renin
vernacular_title: Action antihypertensive du Captopril : étude hémodynamique.