Shigella toxin inhibition of binding and translation of polyuridylic acid by Escherichia coli ribosomes.
Shigella toxin inhibits polyuridylic acid-directed polymerization of phenylalanine in ribosome-enzyme systems obtained from Escherichia coli or from Shigella dysenteriae. The inhibition is the result of toxin acting on ribosomes to prevent polyuridylic acid attachment.
D001427:Bacterial Toxins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli; D010452:Peptide Biosynthesis; D010649:Phenylalanine / Q000378:metabolism; D011072:Poly U / Q000378:metabolism*; D012270:Ribosomes / Q000187:drug effects / Q000378:metabolism*; D012762:Shigella dysenteriae; D013997:Time Factors
D001427:Bacterial Toxins; D011072:Poly U; D010649:Phenylalanine