Age-dependent responsiveness of T lymphocytes to allogeneic and PHA stimulation.
In the course of family investigations a linear age-dependent decrease of reactivity against pooled allogeneic lymphocytes was found between 20 and 70 yr of age. This decreasing tendency was ascertained also by the investigation of unrelated people of a more advanced age. In the elderly, maximal transformation values in PHA stimulation investigated at different PHA doses showed a similar degree of reduction as allogeneic reactivity, and a good correlation between the two parameters of T-lymphocyte function has been found.
D000328:Adult; D000368:Aged; D000375:Aging; D000941:Antigens; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D010835:Phytohemagglutinins