Various lipopolysaccharides reduce adhesion of periodontal ligament fibroblasts.
The interaction of LPS from Bacteroides fragilis, Escherichia coli, Salmonella typhimurium and lipid A from S. typhimurium with adhesion of human periodontal cells on plastic surfaces has been studied. The results showed that LPS and lipid A reduced adhesion already after 5 min at concentrations from 5 to 200 microgram/ml without influencing cell viability. It could be demonstrated that LPS and lipid A interact with both the cell and the substratum surface. Lipid A from S. typhimurium was more potent than any of the LPS used.
D001441:Bacteroides fragilis; D002448:Cell Adhesion / Q000187:drug effects; D002452:Cell Count; D002478:Cells, Cultured / Q000166:cytology; D004926:Escherichia coli; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology*; D010513:Periodontal Ligament / Q000166:cytology*; D012486:Salmonella typhimurium; D013997:Time Factors
D008070:Lipopolysaccharides