Selective IgA deficiency in Australian blood donors.
Selective serum IgA deficiency (defined as a serum IgA level less than 50 mg/l) was detected in 14 of 6,191 Australian blood donors screened by double diffusion analysis of serum specimens in agarose. This prevalence rate of 0.23% (1 in 442) is the same as that found in blood donors in Sweden but is higher than rates found in blood donors in France (0.05%), Norway (0.08%), USA (0.15%). England (0.19%) and Finland (0.20%). Antibodies to human IgA were detected in the serum of three of 11 blood donors with selective IgA deficiency (27%). There was no evidence in the present study of blood transfusion reactions from these anti-IgA antibodies when they were transfused into recipients.
D000293:Adolescent; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D001315:Australia; D001782:Blood Donors; D001803:Blood Transfusion; D004406:Dysgammaglobulinemia / Q000453:epidemiology*; D006801:Humans; D017098:IgA Deficiency; D008297:Male
D000888:Antibodies, Anti-Idiotypic