title: [Formation, persistence period and protective role of antihemagglutinins to earlier circulating influenza A viruses].
abstract: Surveys of the population immunity as well as blood sera from human subjects vaccinated with vaccine strains done by the HI test showed the immunity to previously prevalent influenza A viruses to be maintained by anamnestic stimulation of immunogenesis occuring during circulation of the current agent. The intensity of anamnestic immunity stimulation is determined by the degree of relationship of the current strain hemagglutinin with the similar antigen of previously prevalent viruses. Circulating antibodies have a certain protective effect only against those influenza A viruses which are antigenically related within the drift alteration of hemagglutinin.
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis*; D006389:Hemagglutinins, Viral / Q000276:immunology*; D006801:Humans; D007109:Immunity; D007114:Immunization; D009980:Influenza A virus / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology; D013997:Time Factors
chemical_list: D000888:Antibodies, Anti-Idiotypic; D006389:Hemagglutinins, Viral
vernacular_title: Formirovanie, dlitel'nost' sokhraneniia i zashchitnaia rol' antigemagliutininov k ranee tsirkulirovavshim virusam grippa A.