Comparative distribution of Baker's antifolate (NSC 139105) in rat tissues after subcutaneous and intravenous injections.
The tissue distribution of BAF was compared by intravenous and subcutaneous injections in rats bearing Walker 256 carcinoma. Following a single dose (6 mg/kg containing 30 microCi 4,6-di-14C-BAF), the drug concentrations were determined by radiochemical and dihydrofolate reductase assays. The two methods gave comparable results. No metabolites were found by paper chromatographic separations.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D002279:Carcinoma 256, Walker / Q000032:analysis / Q000188:drug therapy*; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007422:Intestines / Q000032:analysis; D008099:Liver / Q000032:analysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014227:Triazines / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use
D000970:Antineoplastic Agents; D014227:Triazines; C012071:triazinate