Alpha-1-antitrypsin (AAT) deposits in gall bladder adenocarcinoma and liver in partial AAT deficiency (Pi SZ phenotype).
Alpha-1-antitrypsin (AAT) immunoreactive inclusions were found in an adenocarcinoma of a gall bladder of a patient with Pi SZ phenotype who also had globular AAT accumulation in the liver. The inclusions did not react with antibodies against other plasma proteins, thus suggesting a primary synthesis of AAT in these cells. The presence of AAT in the tumor cells may represent resurgence of an oncofetal antigen, or, indirectly, may mean that AAT-containing cells normally exist in the human non-neoplastic gall bladder. The accumulation of AAT in tumor cells might be a basic process in malignant transformation.
D000230:Adenocarcinoma / Q000032:analysis* / Q000473:pathology; D000368:Aged; D005706:Gallbladder Neoplasms / Q000032:analysis* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000032:analysis*; D008297:Male; D010641:Phenotype; D000515:alpha 1-Antitrypsin / Q000032:analysis*; D019896:alpha 1-Antitrypsin Deficiency
D000515:alpha 1-Antitrypsin