A method for increasing the frequency response of voltage clamped myelinated nerve fibres.
In voltage clamp experiments on myelinated nerve fibres the time resolution of the current measurement is limited by the low-pass characteristics of the internodes. We increased the corner frequency of the current passing internode by grounding one half of this internode externally. Using a simplified equivalent circuit we calculated an increase in the bandwidth of the internode by a factor of about 6. Consequently, the peak value of the recorded capacity current increased while its duration was considerably shortened.
D000818:Animals; D004553:Electric Conductivity; D004594:Electrophysiology; D008566:Membranes / Q000502:physiology; D008722:Methods; D009412:Nerve Fibers / Q000502:physiology; D009413:Nerve Fibers, Myelinated / Q000502:physiology*; D011893:Rana esculenta / Q000502:physiology