title: Increased sodium content and altered sodium transport in thymocytes of spontaneously hypertensive rats.
abstract: 1. The intracellular sodium content and the sodium efflux rate constant have been determined in vitro in thymocytes derived from the Okamato-Aoki strain of spontaneously hypertensive rats. 2. A strong positive correlation between the systolic blood pressure and the sodium content of thymocytes was observed (r = 0.59, n = 39, P less than 0.001). 3. The rate constant for total sodium efflux was negatively correlated with systolic blood pressure (r = -0.43, n = 45, P less than 0.005) and this was due to a fall in the ouabain-sensitive component of sodium efflux. 4. Sodium efflux, influx and the thymocyte potassium content were not related to the blood pressure.
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D001794:Blood Pressure; D006973:Hypertension / Q000378:metabolism*; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism*
chemical_list: D012964:Sodium