[Absence of a stimulating effect of T-lymphocytes on the colony-forming activity of splenic hematopoietic stem cells].
Interaction of thymocytes with polypotent stem hemopoietic cells (PSHC) from the bone marrow and spleen was studied in the syngeneic system with the use of a model of an intermediate lethally irradiated recipient, in the spleen of which there is a contact between the test populations, as well as in the donor-recipient semi-allogeneic system. The PSHC of the bone marrow were found to differ in principle from those of the spleen. The difference concerned the regulatory importance of T-cells for stem hemopoietic elements. Thymocytes examined in both the systems stimulated proliferation of bone marrow PSHC but did not affect proliferation of spleen stem cells.
D000818:Animals; D001853:Bone Marrow / Q000276:immunology; D003114:Colony-Forming Units Assay; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D007114:Immunization; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013154:Spleen / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
Otsutstvie stimuliruiushchego éffekta T-limfotsitov na kolonieobrazuiushchuiu aktivnost' stvolovykh krovetvornykh kletok selezenki.