Susceptibility of Haemophilus influenzae type b to cefaclor and influence of inoculum size.
Cefaclor appeared to be an effective antibiotic against both beta-lactamase-positive and beta-lactamase-negative strains of Haemophilus influenzae type b when tested with 10(5) colony-forming units per ml. With inocula in excess of 10(6) colony-forming units per ml, these organisms were neither inhibited nor killed at concentrations of 400 micrograms/ml. This inoculum effect was also demonstrated in time-kill curve studies.
D002433:Cefaclor / Q000494:pharmacology*; D002506:Cephalexin / Q000031:analogs & derivatives*; D006193:Haemophilus influenzae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
D002433:Cefaclor; D002506:Cephalexin