Requirement of T cells for the development of spontaneous autoimmune thyroiditis in obese strain (OS) chickens.
A combination of neonatal thymectomy and intensive treatment with a highly specific turkey anti-chicken T cell serum effectively abrogates the spontaneous development of thyroiditis and thyroglobulin autoantibodies in the Obese strain chicken. Thus, in addition to a restraining influence of suppressor T cells on the disease process indicated by earlier studies, it would appear that T cells also make a positive contribution to pathogenesis.
D000818:Animals; D000918:Antibody Specificity; D000961:Antilymphocyte Serum / Q000276:immunology; D001323:Autoantibodies; D002645:Chickens; D004306:Dose-Response Relationship, Immunologic; D006087:Graft vs Host Reaction; D009765:Obesity / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D013934:Thymectomy; D013966:Thyroiditis / Q000276:immunology*; D013997:Time Factors; D014422:Turkeys
D000961:Antilymphocyte Serum; D001323:Autoantibodies