Phenytoin and formation of T lymphocyte rosettes.
Phenytoin sodium has been associated with the formation of altered T lymphocyte rosettes in vitro. To investigate the clinical relevance of this observation, the formation of T lymphocyte rosettes in nine patients was studied before treatment with phenytoin and after therapeutic concentrations of the drug in plasma were attained. The percentage of total rosette-forming cells found before treatment was not significantly different from the percentage found 24 hours after treatment. Likewise, the percentage of active rosette-forming cells before phenytoin therapy was not significantly less than after therapy. These results suggest that in vivo treatment with phenytoin does not acutely inhibit the formation of T lymphocyte rosettes.
D000328:Adult; D000368:Aged; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects* / Q000097:blood; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects*
D010672:Phenytoin