Elicitation of delayed-type hypersensitivity responses to poly(L-Tyr,LGlu)-poly(DLAla)--poly(LLys) by anti-idiotypic antibodies.
The in vivo effect of murine anti-idiotypic serum against C3H.SW anti-poly(LTyr,LGlu)-poly(DLAla)-(LLys) [(T,G)-A--L] antibodies on delayed type hypersensitivity responses to (T,G)-A--L was studied. Anti-idiotypic serum could challenge DTH responses in C3H.SW mice transferred with antigen-sensitized T cells. The elicitation activity was shown to be antigen and strain specific. With H-2-compatible (but allotype different) strain combinations of (T,G)-A--L-educated T cells and recipients, we were able to show that the biological effect of the anti-idiotypic serum is expressed on the first antigen-sensitized idiotype-positive radioresistant T cell, but not on the proliferating normal cells of recipient origin that participate in the efferent phase of delayed-type hypersensitivity responses to (T,G)-A--L.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008815:Mice, Inbred Strains; D010455:Peptides / Q000276:immunology*; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D007130:Immunoglobulin Idiotypes; D010455:Peptides