Significance of cell kinetic studies in experimental allergic arthritis: participation of monocytes in injury and recovery of the inflamed synovial membrane.
Experimental allergic arthritis in guinea pig has been investigated as a model of immunosynovitis. The course of synovial injury and recovery is quantitatively estimated by microscopic and autoradiographic evaluation. Using 3-H-thymidine pulse and prelabeling techniques it has been shown, that bone marrow derived monocyte-macrophage cells play a major role in the histopathogenesis of this form of arthritis. Cell kinetic studies during the initiation of experimental synovitis support the hypothesis, that so-called lining cell hyperplasia is predominantly due to infiltration by blood monocytes, which during the stage of recovery contribute to a secondary lining cell layer. The early bone and cartilage erosions are additional lesions, which appear to be dependent on the monocyte-macrophage system.
D000818:Animals; D001168:Arthritis / Q000503:physiopathology*; D001345:Autoradiography; D001854:Bone Marrow Cells; D002452:Cell Count; D005260:Female; D005856:Germ-Free Life; D006168:Guinea Pigs; D006967:Hypersensitivity / Q000276:immunology / Q000503:physiopathology*; D007700:Kinetics; D007719:Knee Joint / Q000378:metabolism; D013583:Synovial Membrane / Q000378:metabolism / Q000473:pathology; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D014316:Tritium; D013936:Thymidine