Immunological follow-up of non-Hodgkin's lymphoma (NHL) in children.
Concentrations of immunoglobulins IgG, IgM, IgA, E-, EAC-rosette forming lymphocyte counts and phagocytic function of granulocytes to Staphylococcus aureus were studied during the long-term polychemotherapy in 19 children with NHL and in the control group consisting of 15 healthy children. The decrease in levels of IgA and IgM, E and EAC rosetting lymphocyte counts following intensive long therapy was observed. No significant variations in immunoglobulin subclasses levels before and after single cytostatic cycle were found. The granulocyte phagocytic activity in NHL patients was above normal range. For evaluation of the prognostic value of NHL immunological classification survival rate curves were analyzed. It has been demonstrated that T-lymphoblasts proliferation is an unfavorable prognosis marker.
D000293:Adolescent; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007165:Immunosuppression Therapy; D007958:Leukocyte Count; D007962:Leukocytes / Q000502:physiology*; D008223:Lymphoma / Q000188:drug therapy / Q000276:immunology*; D010587:Phagocytosis; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D007136:Immunoglobulins