Synthesis and pharmacological activity of some 2,3-dihydrofuran-2,3-dione derivatives.
New 2,3-dihydrofuran-2,3-dione derivatives (1-11) were obtained by condensation of oxalyl chloride with Schiff bases of acetyl- or benzoylacetone and aromatic amines. These compounds showed only weak sedative action and weak analgesic effect.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D000927:Anticonvulsants; D055598:Chemical Phenomena; D002621:Chemistry; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology; D006591:Hexobarbital / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D000700:Analgesics; D000927:Anticonvulsants; D005663:Furans; D006591:Hexobarbital; D006916:5-Hydroxytryptophan