New anthracyclinone metabolites from two blocked mutants of Streptomyces galilaeus MA144-M1.
Two blocked mutants of the aclacinomycin-producing Streptomyces galilaeus MA144-M1 produced new anthraquinones and anthracyclinones. The mutant ANR-58 produced compounds 58A, 58B, 58C (7-deoxy-2-hydroxyaklavinone), 58D (2-hydroxyaklavinone) and 58WR. All these compounds have the 2-hydroxyl group. The mutant ANR-665 produced compounds 665A and 665B. The compounds 58A, 58B and 665A have an anthraquinone skeleton.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D000903:Antibiotics, Antineoplastic; D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D009682:Magnetic Resonance Spectroscopy; D009154:Mutation; D009279:Naphthacenes / Q000096:biosynthesis; D009285:Naphthoquinones / Q000096:biosynthesis; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes; D009285:Naphthoquinones