Epithelioid granuloma induced by muramyl dipeptide in immunologically deficient rats.
When WKA rats were either neonatally thymectomized or injected with anti-rat thymocyte sera, their T-cell functions were effectively suppressed. When neonatally thymectomized plus anti-rat thymocyte serum-treated rats were injected with non-immunogenic muramyl dipeptide in water-in-oil emulsion, they produced massive epithelioid granulomas. Essentially, no morphological difference was noticed between granulomas induced in untreated rats and in thymectomized plus anti-rat thymocyte serum-treated rats. These findings strongly suggest that muramyl dipeptide-induced epithelioid granulomas required no T cells for their formation. In contrast, the induction of adjuvant arthritis appeared to depend on the presence of T cells.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000276:immunology*; D000818:Animals; D000961:Antilymphocyte Serum; D001169:Arthritis, Experimental / Q000276:immunology; D004848:Epithelium / Q000276:immunology; D005260:Female; D006020:Glycopeptides / Q000276:immunology*; D006099:Granuloma / Q000276:immunology*; D007108:Immune Tolerance; D008198:Lymph Nodes / Q000276:immunology; D008297:Male; D051381:Rats; D012871:Skin Diseases / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013934:Thymectomy
D000961:Antilymphocyte Serum; D006020:Glycopeptides; D000119:Acetylmuramyl-Alanyl-Isoglutamine