Plasminogen activator activity in the subunits of mouse submandibular gland nerve-growth factor and epidermal growth factor.
The 7S nerve-growth factor (7S NGF), high molecular weight epidermal growth factor (HMW-EGF) and their subunits were isolated from mouse submandibular gland. Plasminogen activator activity was found in the 7S NGF and HMW-EGF, as well as in the gamma subunit and EGF-binding protein. Later activities were two- or three-fold higher than those of original growth factors. The alpha subunit, beta subunit and low molecular weight EGF showed no activity. The gamma 1, gamma 2 and gamma 3 subunits of 7S NGF showed plasminogen activator activity almost equal to that of the original gamma subunit.
D000818:Animals; D004815:Epidermal Growth Factor / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008970:Molecular Weight; D009414:Nerve Growth Factors / Q000378:metabolism*; D010960:Plasminogen Activators / Q000378:metabolism*; D013363:Submandibular Gland / Q000201:enzymology*
D009414:Nerve Growth Factors; D004815:Epidermal Growth Factor; D010960:Plasminogen Activators