Effects of benoxaprofen on the inflammatory, humoral and cellular components of type II collagen-induced arthritis in rats.
The effects of benoxaprofen and some other anti-inflammatory drugs on the inflammatory, cellular, and humoral components of type II collagen-induced arthritis in rats were studied. At the given dosage (mg/kg/day), benoxaprofen (10), aspirin (25), and indomethacin (3) inhibited the hindpaw swelling and development of anti-type II collagen antibodies in collagen-treated rats. Benoxaprofen also inhibited the delayed-type hypersensitivity response to collagen. Phenylbutazone (30) failed to show significant effect on these parameters. The treatment of rats with benoxaprofen throughout the test period or during days 14 to 28 was more effective than the treatment in the initial phases only.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects; D001168:Arthritis / Q000503:physiopathology*; D001169:Arthritis, Experimental / Q000276:immunology / Q000503:physiopathology*; D003094:Collagen / Q000633:toxicity; D007111:Immunity, Cellular / Q000187:drug effects; D007249:Inflammation / Q000503:physiopathology; D011422:Propionates / Q000494:pharmacology*; D051381:Rats; D011917:Rats, Inbred Lew; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D011422:Propionates; C011677:benoxaprofen; D003094:Collagen