Measurement of sodium valproate in serum by direct-insertion chemical-ionization/mass spectrometry.
To quantitatively determine sodium valproate, we use a stable isotope-labeled internal standard and chemical-ionization/mass spectrometry, without prior chromatographic separation. The technique is rapid, simple, sensitive, and provides for the routine analysis of 100 microL of serum with good within-day and day-to-day precision. The technique also allows for the simultaneous determination of phenobarbital, mephobarbital, carbamazepine, primidone, and phenytoin.
D002220:Carbamazepine; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D008832:Microchemistry; D010634:Phenobarbital; D014635:Valproic Acid / Q000097:blood*
D002220:Carbamazepine; D014635:Valproic Acid; D010634:Phenobarbital