Human B-blast specific target determinants in CML: a family study.
Human B blast specific target determinants, selectively identified on PWM stimulated purified B lymphoblasts by in vitro generated CTLs, have previously been studied in the population and showed association to and inclusion of HLA-DR geneproducts. This report indicates that B blast target determinants are products of genes which in a codominant mendelain way segregate with the HLA haplotypes in 4 selected families. Furthermore tests of families with HLA-B/D, DR and HLA-D, DR/GLO recombinations show that human B blast specific target determinants are coded from loci (locus) in the HLA-D region, between HLA-B and GLO.
D001402:B-Lymphocytes / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006238:Haploidy; D006801:Humans; D008213:Lymphocyte Activation; D014176:Protein Biosynthesis; D013601:T-Lymphocytes / Q000276:immunology
D006680:HLA Antigens