[Stress-metabolism after myocardial infarction-demonstrated by means of the behaviour of plasma proteins with short half-life (author's transl)].
The kinetics of plasma proteins with short half-life during stress-metabolism in patients after myocardial infarction with and without clinical complications and after angina pectoris were compared. The acute-phase proteins alpha1-antitrypsin, C-reactive protein (CRP), fibrinogen, haptoglobin, and the transport proteins prealbumin and transferrin were analyzed with the method of radial immunodiffusion. Whereas angina pectoris doesn't influence the protein kinetics, one can recognize after myocardial infarction a continuous increase of the acute-phase proteins to maxima between the 3rd and 5th day after the attack. Parallel to these changes, the transport proteins decrease with subsequent increase. The changes, which are similar to those seen after surgical trauma, are dependent on the severity of illness, and can be used as prognostic parameters. During stress metabolism, the concentrations of the proteins depending on nutrition, prealbumin and transferrin, are modified by the type and severity of stress, and by nutritional influences. The mechanisms of these changes and the consequences for their use as diagnostic parameters are discussed.
D000368:Aged; D000787:Angina Pectoris / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D004562:Electrocardiography; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006207:Half-Life; D006242:Haptoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000097:blood*; D011228:Prealbumin / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism; D013312:Stress, Physiological / Q000097:blood*; D014168:Transferrin / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D001798:Blood Proteins; D006242:Haptoglobins; D011228:Prealbumin; D012709:Serum Albumin; D014168:Transferrin; D000515:alpha 1-Antitrypsin; D005340:Fibrinogen; D002097:C-Reactive Protein
Postaggressionsstoffwechsel nach Herzinfarkt--dargestellt am Verhalten kurzlebiger Plasmaproteine.