title: Effect of ketone body infusion on plasma catecholamine and substrate concentrations during acute hypoglycemia in man.
abstract: Experimental studies have shown that ketone body infusion inhibits the catecholamine response to hypoglycemia. We have studied six men during insulin-induced hypoglycemia who were concomitantly infused with saline or 3-hydroxybutyrate at dose rates of 4 and 13 mg/kg.min. The mean blood concentrations of 3-hydroxybutyrate increased to about 0.45 and 3 mmol/liter, respectively. The results show that the glucose response to insulin; hypoglycemic symptoms; and the adrenaline, noradrenaline, and cortisol responses to hypoglycemia were not influenced by ketone infusion at any dose rate.
mesh_terms: D020155:3-Hydroxybutyric Acid; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002395:Catecholamines / Q000097:blood*; D004837:Epinephrine / Q000097:blood; D006801:Humans; D006885:Hydroxybutyrates / Q000494:pharmacology; D007003:Hypoglycemia / Q000097:blood* / Q000139:chemically induced; D007328:Insulin; D007657:Ketone Bodies / Q000097:blood / Q000494:pharmacology*; D007773:Lactates / Q000097:blood; D008297:Male; D009638:Norepinephrine / Q000097:blood
chemical_list: D001786:Blood Glucose; D002395:Catecholamines; D006885:Hydroxybutyrates; D007328:Insulin; D007657:Ketone Bodies; D007773:Lactates; D020155:3-Hydroxybutyric Acid; D009638:Norepinephrine; D004837:Epinephrine