Advantages of low dose steroid from the day after renal transplantation.
We have used a low dose of steroid (20 mg of prednisolone), commencing the day after transplantation, for 151 consecutive renal transplants in 141 patients. Five patients received grafts from living related donors, 146 received cadaver grafts. All patients received azathioprine for routine immunosuppression and the first 47 received a single dose of actinomycin C i.v. for treatment of rejection. No other immunosuppressive drugs were used. This treatment provided satisfactory immunosuppression as 109 of 151 grafts continue to function for periods of 3 months to 10 years and, of 42 grafts lost, only 17 failed from rejection. The cumulative survival of first cadaver grafts at 1 and 2 years in recipients of all ages (7 to 55 years) was 77.9 and 76.0%, respectively; in recipients 15 to 34 years old, 90.9 and 86.1%, respectively. Twenty-three patients died, no patient died from infection during the admission for transplantation, and infection played a part in the deaths of only four patients. The incidence of other complications was low; seven patients developed gastrointestinal complications, one died, four patients developed diabetes, all survived; only one patient developed avascular necrosis of bone.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001379:Azathioprine / Q000494:pharmacology; D002102:Cadaver; D002648:Child; D003920:Diabetes Mellitus / Q000139:chemically induced; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006085:Graft Survival / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D016030:Kidney Transplantation; D008875:Middle Aged; D010020:Osteonecrosis / Q000139:chemically induced; D011239:Prednisolone / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D014184:Transplantation, Homologous
D011239:Prednisolone; D001379:Azathioprine; D006854:Hydrocortisone