Cryptococcosis with multiple squamous cell tumors associated with a T-cell defect.
A 54-year-old male with multiple squamous cell tumors was shown to have capsule deficient cryptococcosis confined to bone. Further investigations revealed a severe defect of cell-mediated immunity and the presence of serum antinuclear factor. An underlying T-cell defect might explain the unusual cryptococcal infection and the extremely aggressive behavior of the skin tumors.
D001842:Bone and Bones / Q000382:microbiology; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology; D003453:Cryptococcosis / Q000150:complications* / Q000473:pathology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology; D013601:T-Lymphocytes