Acid response to sham feeding as a test for completeness of vagotomy.
The reproducibility of acid responses to modified sham feeding by the chew-and-spit technique (PAOsh) was investigated in 21 duodenal ulcer (DU) patients 8 to 14 days after vagotomy. Possible relationships between PAOsh and the acid response to 0.2 U of insulin per kilogram body weight were examined (PAOI) in 23 other DU patients 8 to 14 days after vagotomy. PAOsh was reproducible to a high degree (PSpearman less than 0.001, CV 2.9%), and a highly significant relationship was found between PAOsh and PAOI after vagotomy (PSp less than 0.001). PAOsh and PAOI were similar when PAOI was low, whereas a highly incomplete vagotomy according to PAOI was followed by a somewhat lower, but substantial, acid response to sham feeding. The relationship between PAOsh and PAOI permits the recommendation of modified sham feeding as a safe stimulant of acid secretion in quantitative testing of completeness of vagotomy.
D000328:Adult; D000368:Aged; D004381:Duodenal Ulcer / Q000503:physiopathology* / Q000601:surgery; D005247:Feeding Behavior; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D007328:Insulin; D008297:Male; D008409:Mastication; D008875:Middle Aged; D010418:Pentagastrin; D014628:Vagotomy
D007328:Insulin; D010418:Pentagastrin