[Detection of a distinctive differentiating antigen of activated mouse T- and B-lymphocytes--AKA-1].
The presence of a differentiative antigen on activated B cells -- antibody forming cells (AFC), analogous to that against mouse T lymphocytes activated by transplantation antigens was demonstrated with the help of specific rabbit antiserum (ATactS) against these T lymphocytes. The antigen was detectable on direct AFC producing antibodies to sheep, rabbit and rat red blood cells as well as on indirect AFC producing antibodies to sheep red blood cells. The antigen was found on AFC of different H-2 and Ala-1 phenotypes. The activity of ATactS was abolished by absorption with activated T cells, EL-4 lymphoma cells rather than by intact lymphocytes, liver cells, serum or immunoglobulin of mice. The differentiative antigen common to activated T and B cells is proposed to be designated Aka-1.
D000818:Animals; D000941:Antigens / Q000032:analysis*; D001402:B-Lymphocytes / Q000276:immunology*; D008213:Lymphocyte Activation; D008223:Lymphoma / Q000276:immunology; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D010954:Plasmacytoma / Q000276:immunology; D011817:Rabbits / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens
Obnaruzhenie osobogo differentsirovochnogo antigena aktivirovannykh T- i B-limfotsi tov mysheĭ--AKA-1.