Prostaglandin levels and lysosomal enzyme activities in irradiated rats.
Whole-body irradiation of rats results in the release of hydrolases from lysosomes, an increase in lysosomal enzyme activities, and changes in the prostaglandin levels in spleen and liver tissues. A transient increase in the concentration of prostaglandins E and F and leakage of lysosomal hydrolases occurred in both spleen and liver tissues 3-6 hours after the animals were irradiated. Maximal values for hydrolase activities, prostaglandin E and F content, and release of lysosomal enzymes were found 4 days postirradiation in rat spleens whereas in the liver only slight increases were observed at this time period for prostaglandin F levels. On day 7 there was a final rise in the spleen's prostaglandin E and F concentrations and leakage of hydrolases from the lysosomes before returning to near normal values on day 11. The prostaglandin F concentration in liver was also slightly elevated on the 7th day after irradiation and then decreased to control levels.
D000818:Animals; D005720:Gamma Rays; D005966:Glucuronidase / Q000378:metabolism / Q000528:radiation effects; D006867:Hydrolases / Q000032:analysis; D008099:Liver / Q000032:analysis / Q000201:enzymology / Q000528:radiation effects*; D008247:Lysosomes / Q000201:enzymology / Q000528:radiation effects*; D008297:Male; D011458:Prostaglandins E / Q000032:analysis; D011460:Prostaglandins F / Q000032:analysis; D051381:Rats; D013154:Spleen / Q000032:analysis / Q000201:enzymology / Q000528:radiation effects*; D013997:Time Factors
D011458:Prostaglandins E; D011460:Prostaglandins F; D006867:Hydrolases; D005966:Glucuronidase