title: Effect of preanaesthetic medication on anaesthesia with ICI 35, 868.
abstract: The effect of three commonly used premedicants and a control on anaesthesia with ICI 35, 868 is described. Two randomized studies were performed--one a group study of induction characteristics at 2 mg kg-1 and the other a detailed study in patients undergoing minor gynaecological surgery with an induction dose of 1.5 mg kg-1 and maintenance with incremental doses plus 66% nitrous oxide in oxygen. Premedication had little effect on the already good induction characteristics. Only heavy opiate premedication produced reliable induction at 1.5 mg kg-1, but with an increase in side-effects. Diazepam appears to be the premedicant of choice, although the overall frequency of pain on injection has not been affected by premedication.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000008:administration & dosage; D001285:Atropine; D003975:Diazepam; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008614:Meperidine; D008875:Middle Aged; D009892:Opium; D010636:Phenols / Q000008:administration & dosage; D011229:Preanesthetic Medication; D015742:Propofol; D012601:Scopolamine
chemical_list: D000777:Anesthetics; D010636:Phenols; D001285:Atropine; D009892:Opium; D008614:Meperidine; D012601:Scopolamine; D003975:Diazepam; D015742:Propofol