[Effects of levamisole on methylcholanthrene-induced tumor. II. Potentiation of cytotoxic T-cell activities].
1) Levamisole(LMS) augmented the ability to inhibit specifically the growth of secondary Meth 1 tumors in Meth 1-bearing BALB/c mice. 2) When spleen cells of Meth 1-bearing mice were restimulated in vitro with MMC-treated Meth 1 cells, cytotoxicity became detected by 51 Cr release assay. Such cytotoxicity was augmented by in vivo treatment with LMS. The cytotoxicity was tumor-specific and completely abrogated by incubation with anti-thy 1.2 antibody and complement before the assay. 3) Cytostatic activity of peritoneal macrophages induced by i. p. inoculation with MMC-treated Meth 1 cells was augmented by LMS treatment of Meth 1-bearing mice but such an activity was not Meth 1-specific. 4) LMS did not augment the natural killer cell activity of the spleen cells of BALB/c mice or BALB/c nude mice. These results suggested that the growth-inhibitory effect of LMS against secondary tumors was mediated by cytotoxic T-cells.
D000276:Adjuvants, Immunologic; D000818:Animals; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D007978:Levamisole / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects* / Q000276:immunology
D000276:Adjuvants, Immunologic; D007978:Levamisole