The short effect of pelvic radiotherapy of gynecological cancers on humoral and cell mediated immunity.
An analysis of short effect of pelvic irradiation on cellular and humoral immunity was made in 24 patients treated by irradiation alone or a combination of surgery and irradiation for uterine carcinoma, at 2, 6, 12 months after loco-regional therapy. Twelve months later there is a decrease of T lymphocytes (P = 0.01), whereas the B lymphocytes count is normal; the percentage of T and B lymphocytes remains stable, but the lymphocyte response to PHA after 3 days is reduced (p = 0.03). A significant decrease of immunoglobulins G, A and M is observed.
D000328:Adult; D000368:Aged; D000917:Antibody Formation / Q000528:radiation effects; D001402:B-Lymphocytes / Q000528:radiation effects; D005260:Female; D005833:Genital Neoplasms, Female / Q000276:immunology / Q000532:radiotherapy*; D006801:Humans; D007111:Immunity, Cellular / Q000528:radiation effects; D008875:Middle Aged; D010388:Pelvis; D013601:T-Lymphocytes / Q000528:radiation effects; D013997:Time Factors