[Redistribution of populations of T- and B-lymphocytes among lymphoid organs in response to hydrocortisone].
Single injection of hydrocortisone to guinea-pigs provoked a remarkable transitory T-lymphocytopenia with transition of T- lymphocytes into the bone marrow during the early stages. On the contrary, the content of B-lymphocytes in the peripheral blood gradually rose and exceeded the normal level twice as much by the end of the first day. Histological analysis did not reveal any signs of massive destruction of lymphocytes. It is suggested that the redistribution mechanism lies at the basis of changes in the lymphocyte population ratio induced by corticosteroid administration.
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects*; D001854:Bone Marrow Cells; D002452:Cell Count; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000494:pharmacology*; D007958:Leukocyte Count; D008221:Lymphoid Tissue / Q000187:drug effects*; D013601:T-Lymphocytes / Q000187:drug effects*
D006854:Hydrocortisone
Pereraspredelenie popliatsii T- i B-limfotsitov mezhdu limfoinymi organami pod vliianiem gidrokortizona.