The characterization of the delayed-type hypersensitivity reaction to H-Y antigens.
We have evaluated the ability of certain inbred strains of mice to develop a delayed-type hypersensitivity response to the male H-Y antigen. It was found that C57BL/10, B10.GD and B10.A(5R) female mice responded to syngeneic male cells. B10.A(4R) females also responded to B10.A(4R) male cells although the reactivity was somewhat slighter. B10.A(2R), B10.D2 and BALB/c female mice could not respond to immunization with syngeneic male cells. The response was male-antigen specific and transferable by thymus-derived cells. Moreover, suggestive evidence of representation of H-Y was obtained, based on the ability of responder strains immunized with syngeneic cells to react to nonresponder male cells upon challenge.
D000818:Animals; D000950:Antigens, Ly / Q000235:genetics; D005260:Female; D006182:H-Y Antigen / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008810:Mice, Inbred C57BL / Q000276:immunology; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology; D014181:Transplantation Immunology
D000950:Antigens, Ly; D006182:H-Y Antigen