[Contact interaction of mast cells and lymphocytes during ontogenetic antigen-induced differentiation and malignant transformation of lymphoid cells].
Mastocytes of newborn rats as well as those of adult ones are capable of rosette-formation, whereas the ability of lymphocytes to from rosettes increases with age. The thymocytes of 3-month-old mice lose the ability to mastolymphocytic rosette-formation (MLR) after priming for one hour at 45 degrees C. The ability of thymocytes and splenocytes to MLR-formation is closely related to the time course of immunization of the animals and the method of immunization. The thymocytes and splenocytes of mice with leukemia show a decreased and increased ability to MLR-formation, respectively.
D000367:Age Factors; D000818:Animals; D008214:Lymphocytes / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology*; D051379:Mice; D008806:Mice, Inbred AKR; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D012397:Rosette Formation; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
Kontaktnoe vzaimodeĭstvie masto- i limfotsitov pri ontogeneticheskoĭ, antigen indutsirovannoĭ differentsirovke i zlokachestvennoĭ transformatsii limfoidnykh kletok.