Non-specific cell mediated immunity in patients infected with Schistosoma mansoni in Kenya.
Parameters of in vitro cell-mediated immunity (CMI) have been measured in the local Kenyan population infected with Schistosoma mansoni. Lymphocyte responses to the non-specific T cell mitogens Concanavalin A (Con A) and Phytohaemagglutinin (PHA) were reduced in about 60% of schistosomiasis patients. Lymphocytes from control uninfected, and S. mansoni-infected donors formed equal numbers of spontaneous rosettes with sheep red blood cells, indicating that there was no over-all reduction in the percentage numbers of T cells in the schistosomiasis patients.
D000293:Adolescent; D000328:Adult; D002648:Child; D003208:Concanavalin A; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008875:Middle Aged; D010835:Phytohemagglutinins; D012397:Rosette Formation; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D010835:Phytohemagglutinins; D003208:Concanavalin A