[Activation of the anticoagulant system by prethrombin 2, a thrombin precursor].
Prethrombin 2, and immediate precursor of thrombin, was obtained by limited trypsin or active factor X proteolysis by prethrombin 1. The conversion of prethrombin 1 to prethrombin 2 does not occur in the absence of enzymes. It has been shown that factor V has no influence on the rate of thrombin generation from prethrombin 2 and that prethrombin itself has no coagulant or esterase activity. Intravenous injection of prethrombin 2 preparations led to an increase in plasma recalcification time, overall fibrinolytic activity and non-enzymatic fibrinolysis. In addition, there was observed a considerable increase in fibrinogen-heparin complex activity. The data obtained indicate excitation of the anticoagulant system with intravenous injection of small doses of prethrombin 2.
D000818:Animals; D001001:Anura; D002384:Catalysis; D004792:Enzyme Precursors / Q000494:pharmacology*; D005165:Factor V / Q000494:pharmacology; D005170:Factor X / Q000031:analogs & derivatives / Q000494:pharmacology; D005342:Fibrinolysis / Q000187:drug effects*; D008297:Male; D011516:Prothrombin / Q000031:analogs & derivatives / Q000494:pharmacology*; D011896:Rana temporaria; D051381:Rats; D013045:Species Specificity; D014357:Trypsin
D004792:Enzyme Precursors; D005165:Factor V; D011516:Prothrombin; D005170:Factor X; C012007:prethrombins; D014357:Trypsin
Aktivatsiia protivosvertyvaiushcheĭ sistemy pretrombinom 2-predshestvennikom trombina.