Testicular in vitro conversion of progesterone to testosterone and androstenedione in 17 alpha-hydroxylase deficiency.
Incubations of [3H]-progesterone with testicular tissue obtained from a new case of male with 17 alpha-hydroxylase deficiency were performed. The per cent conversion to androstenedione and testosterone was virtually absent when compared to that obtained from an identical incubation performed using testicular tissue from a normal male with cryptochordism. The findings provide an in vitro evidence in support of the existence of 17 alpha-hydroxylase testicular defect in this disorder.
D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital; D000328:Adult; D000735:Androstenedione / Q000096:biosynthesis*; D006801:Humans; D007621:Karyotyping; D008297:Male; D011374:Progesterone / Q000378:metabolism*; D012016:Reference Values; D012730:Sex Chromosomes; D013254:Steroid 17-alpha-Hydroxylase / Q000378:metabolism; D013250:Steroid Hydroxylases / Q000172:deficiency*; D013256:Steroids / Q000378:metabolism; D013737:Testis / Q000201:enzymology*; D013739:Testosterone / Q000096:biosynthesis*
D013256:Steroids; D013739:Testosterone; D000735:Androstenedione; D011374:Progesterone; D013250:Steroid Hydroxylases; D013254:Steroid 17-alpha-Hydroxylase; C022445:progesterone 17-alpha-hydroxylase