Goodpasture's syndrome. A report of seven patients including long-term follow-up of three who received a kidney transplant.
Seven patients with Goodpasture's syndrome are presented. Bilateral nephrectomy was performed in five patients, and postnephrectomy pulmonary hemorrhage occurred in three. Three nephrectomized patients underwent a successful renal transplant, renal transplantation being postponed until circulating antiglomerular basement membrane antibody had disappeared. The argument is made that pretransplant bilateral nephrectomy in patients with Goodpasture's syndrome is indicated.
D000293:Adolescent; D000328:Adult; D019867:Anti-Glomerular Basement Membrane Disease / Q000276:immunology / Q000628:therapy*; D000906:Antibodies / Q000032:analysis; D001379:Azathioprine / Q000627:therapeutic use; D001485:Basement Membrane / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology; D016030:Kidney Transplantation; D008297:Male; D009392:Nephrectomy; D011241:Prednisone / Q000627:therapeutic use; D006435:Renal Dialysis; D014184:Transplantation, Homologous
D000906:Antibodies; D001379:Azathioprine; D011241:Prednisone