Influence of local release of indomethacin from a silastic device on uterine prostaglandins F2 alpha and E.
Delivery of indomethacin (approximately 120 micrograms over 23 days) from a unilateral silastic intrauterine device in the rat caused a reduction in the wet weight of the IUD-bearing horn when compared to that of animals with a plain silastic device. The exposure of the uterus to the sustained local release of indomethacin also resulted in a lowering of basal levels of prostaglandins PGF2 alpha and PGE in the tissue as determined by radioimmunoassay. For PGF2 alpha, no marked difference was found in the capability of the tissue to produce it when the IUD horns of the two groups of experimental animals were compared.
D000818:Animals; D003692:Delayed-Action Preparations; D015237:Dinoprost; D005260:Female; D007213:Indomethacin / Q000008:administration & dosage* / Q000494:pharmacology; D007434:Intrauterine Devices; D009929:Organ Size / Q000187:drug effects; D011458:Prostaglandins E / Q000378:metabolism*; D011460:Prostaglandins F / Q000378:metabolism*; D051381:Rats; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism
D003692:Delayed-Action Preparations; D011458:Prostaglandins E; D011460:Prostaglandins F; D015237:Dinoprost; D007213:Indomethacin