Lymphocyte subpopulation in acute viral hepatitis.
Studies of peripheral blood lymphocytes were performed in 41 patients with acute viral hepatitis, in grade III-IV coma; 16 patients were in the third trimester of pregnancy. There were significant reductions in absolute lymphocyte count and T cell number in patients who succumbed to the disease, when compared with those who survived. B cell counts were similar in the two groups and migration inhibition test with BCG antigen was normal. It is postulated that a decrease in the number of cells interacting in cell-mediated immune reactions is related to prognosis in acute viral hepatitis.
D000208:Acute Disease; D001402:B-Lymphocytes; D002464:Cell Migration Inhibition; D005260:Female; D006501:Hepatic Encephalopathy / Q000097:blood / Q000209:etiology; D006525:Hepatitis, Viral, Human / Q000097:blood* / Q000150:complications / Q000401:mortality; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood; D012959:Socioeconomic Factors; D013601:T-Lymphocytes