The influence of catecholamines and prostaglandins on calcium efflux and filtrability of thermally damaged erythrocytes: an in vitro study.
Whole blood was heated in vitro and incubated with any of the following: epinephrine, norepinephrine, prostaglandin E1, prostaglandin E2 or prostaglandin F2 alpha. The treatment was assessed by whole-blood filtration and extrusion of a Ca2+ load from Ca2+ loaded red cells. Epinephrine did not affect the parameters measured. Norepinephrine increased cell filtration times and delayed Ca2+ extrusion. Prostaglandin E1 acted in an opposite manner. prostaglandin E2 and F2 alpha both decreased red-cell deformability and Ca2+ extrusion above the effect of heat alone Prostaglandin E2 showed the most pronounced effect. Possible implications of the findings for microcirculation in burned patients are discussed.
D000527:Alprostadil; D002118:Calcium / Q000097:blood*; D015232:Dinoprostone; D004837:Epinephrine / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D006358:Hot Temperature; D006801:Humans; D009638:Norepinephrine / Q000494:pharmacology*; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D014462:Ultrafiltration
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D000527:Alprostadil; D015232:Dinoprostone; D002118:Calcium; C100006:prostaglandin F1; D009638:Norepinephrine; D004837:Epinephrine