Tumor enhancing T lymphocytes in mice: further studies on characteristics and mechanism of activity.
In order to test the possibility that tumor-enhancing T lymphocytes can suppress other lymphoid cells, such as those with anti-tumor activity, their effect was tested in an allogeneic response of cell-mediated lysis. Normal thymocytes and spleen cells from mice with advanced tumors, two populations which enhance the growth of solid tumors, both suppressed the generation of CML. Since these results suggest that the mechanism of enhancement by T cells may resemble suppression in other immune responses, we looked for Fc receptors on the sensitized cells involved in tumor enhancement. Cells expressing Fc receptors appeared to be necessary for enhancement of tumor growth to occur.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D005354:Fibrosarcoma / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology; D011817:Rabbits; D011961:Receptors, Fc / Q000302:isolation & purification*; D013154:Spleen / Q000032:analysis*; D013601:T-Lymphocytes / Q000276:immunology*
D011961:Receptors, Fc