Clonal characteristics of cutaneous T cell lymphomas: cytogenetic evidence from blood, lymph nodes, and skin.
Chromosome studies were done on mitogen-stimulated lymphocytes from one or more tissues (blood, lymph nodes, skin lesions) in 15 patients with mycosis fungoides or Sézary syndrome. A cytogenetically abnormal clone was found in 10 individuals, including 6 with data from several tissues. In 4 cases the same aberrant clone was identified in a skin lesion as well as in blood and/or lymph node. The abnormal chromosome patterns ranged from hypodiploid to hypertetraploid, and there was no evidence of unrelated karyotypically-altered lines at different sites. A 6q- chromosome, previously reported in acute lymphocytic leukemia, was found in 2 patients. The results support the concept that cutaneous T cell lymphomas (CTCL) are clonal disorders, presumably unifocal in origin, with the skin lesions populated by cells from the same neoplastic clone that involves lymph nodes and blood.
D000368:Aged; D002869:Chromosome Aberrations; D002999:Clone Cells / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008198:Lymph Nodes / Q000648:ultrastructure; D008214:Lymphocytes / Q000648:ultrastructure; D008223:Lymphoma / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000235:genetics; D012751:Sezary Syndrome / Q000235:genetics; D012867:Skin / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000235:genetics*; D013601:T-Lymphocytes