[Comparison of carminomycin and rubomycin action on the dynamics of the immune response to the T-independent Vi-antigen of S. typhi].
The effect of carminomycin and rubomycin on the dynamics of the primary immune response to T-independent Vi-antigen of S. typhi was studied. Differences in the character of the antibiotic effect indicative of the high selective effect of carminomycin on the multiplying cells or precursors of the antibody forming plasmocytes were noted. It was found that the carminomycin inhibitory effect on synthesis of hemagglutinins to Vi-antigen was higher than that to sheep red blood cells. Carminomycin was shown to impair the formation of the immunological memory, while rubomycin did not suppress the development of the "memory cell" clone to T-independent antigen.
D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D000942:Antigens, Bacterial / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D002360:Carubicin / Q000276:immunology*; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000276:immunology*; D007156:Immunologic Memory / Q000187:drug effects; D008297:Male; D051379:Mice; D012485:Salmonella typhi / Q000276:immunology*; D013154:Spleen / Q000187:drug effects; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D000942:Antigens, Bacterial; D000954:Antigens, Surface; D002360:Carubicin; D003630:Daunorubicin
Sravnenie deĭstviia karminomitsina i rubomitsina na dinamiku T-nezavisimomu Vi-antigenu S. typhi.