Pharmacology of 8-aminoquinolines.
The 8-aminoquinolines were the first group of compounds to be synthesized specifically for their antimalarial activity. A large-scale research programme in the United States of America in the 1940s produced three new antimalarial drugs-pentaquine, isopentaquine, and primaquine -of which primaquine was the most effective. This article reviews knowledge on the activity of these 8-aminoquinolines against all stages of the malaria parasite and suggests their possible modes of action. The toxic effects and possible causal mechanisms are also outlined.
D000634:Aminoquinolines / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D001717:Birds; D006801:Humans; D008253:Macaca mulatta; D008288:Malaria / Q000188:drug therapy*; D010961:Plasmodium / Q000187:drug effects; D012377:Rodentia
D000634:Aminoquinolines; D000962:Antimalarials