Regulatory effect of H2-D region antigens in the graft-vs-host response: F1 hybrid resistance to alloreactive T cells.
The role of donor and host H2D alleles in the graft-vs-host response was evaluated by measurement of DNA synthetic response of donor lymph node cells in lethally irradiated hosts and by a mortality assay in sublethally irradiated F1 hosts. Comparison of the potency of graded doses of B10.A, B10.A(2R), and (B10.A X B10.A(2R))F1 cells in (B10 vs B10.A)F1 and other hosts expressing foreign KbIb revealed a deficient response of 10(6) B10.A(2R) cells, but only when the host was heterozygous d/b at H2-D. Studies with TI congenic donors failed to implicate T region antigens in this effect. These results are interpreted to suggest that under the conditions of these experiments there is F1 hybrid resistance to alloaggressive T lymphocytes that are homozygous in the Db region.
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D005260:Female; D006087:Graft vs Host Reaction / Q000528:radiation effects; D006183:H-2 Antigens / Q000235:genetics*; D006824:Hybridization, Genetic; D007519:Isoantigens; D008297:Male; D051379:Mice; D009026:Mortality; D013601:T-Lymphocytes / Q000276:immunology*
D006183:H-2 Antigens; D007519:Isoantigens; D004247:DNA