title: Expression of 20 alpha-hydroxysteroid dehydrogenase in nonlymphoid hemopoietic cell lines.
abstract: Expression of 20 alpha-hydroxysteroid dehydrogenase (20 alpha-SDH), a putative T cell marker, has been examined in a number of nonlymphoid hemopoietic cell lines. Both promyelocytic and stromal bone marrow lines expressed significant 20 alpha-SDH activity which was not correlated with virus infection or growth rate. 20 alpha-SDH therefore is not a unique marker for T cells in hemopoietic tissues. This result is discussed in relationship to the action of the newly proposed interleukin 3.
mesh_terms: D015089:20-Hydroxysteroid Dehydrogenases / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D001853:Bone Marrow / Q000276:immunology* / Q000473:pathology; D002460:Cell Line; D006412:Hematopoietic Stem Cells / Q000276:immunology* / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000276:immunology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D015089:20-Hydroxysteroid Dehydrogenases