title: [Primary neuromeningeal manifestation, isolated for a long period, of acute lymphoblastic leukemia].
abstract: The course of acute leukaemias, particularly of the lymphoblastic type, is very frequently complicated by the development of neuromeningeal localisations of the disease. They may, more rarely, be presenting initial lesions, their origin being confirmed clinically and/or biologically, but it is exceptional that they remain a strictly isolated expression of the affection. A case is reported of a 16-year-old adolescent with leukaemic meningitis, in whom haematological tests (blood counts, bone marrow smear, iliac medullary biopsy, lymph node biopsy) gave negative results over a period of at least two months. Based on the findings in this case, the significance of early neuromeningeal localisations of acute leukaemias is discussed.
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008581:Meningitis / Q000209:etiology*; D008582:Meningitis, Aseptic / Q000134:cerebrospinal fluid / Q000209:etiology*; D011559:Pseudotumor Cerebri / Q000209:etiology
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Expression neuro-méningée primitive et longtemps isolée d'une leucémie aiguë lymphoblastique.