Inhibition of activated factors II, VII, IX, and X by synthetic organic compounds directed against the active-site seryl residue.
A series of 53 organic chemicals belonging to the groups of organic phosphates, sulfonyl derivatives and carbamates were screened for their activity against the coagulation factors IIa (thrombin), VIIa, IXa and Xa. Relatively specific inhibitors for the factors IIa, VIIa and Xa were found.
D002219:Carbamates / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004136:Dinitrobenzenes / Q000494:pharmacology; D005164:Factor IX / Q000037:antagonists & inhibitors*; D015949:Factor IXa; D005167:Factor VII / Q000037:antagonists & inhibitors*; D005170:Factor X / Q000037:antagonists & inhibitors*; D015951:Factor Xa; D006801:Humans; D007531:Isoflurophate / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000494:pharmacology; D010664:Phenylmethylsulfonyl Fluoride / Q000494:pharmacology; D011516:Prothrombin / Q000037:antagonists & inhibitors*; D013438:Sulfhydryl Compounds / Q000494:pharmacology
D002219:Carbamates; D004136:Dinitrobenzenes; D009943:Organophosphorus Compounds; D013438:Sulfhydryl Compounds; D007531:Isoflurophate; D010664:Phenylmethylsulfonyl Fluoride; D005167:Factor VII; D011516:Prothrombin; D005164:Factor IX; D005170:Factor X; C025337:Factor IIa; D015949:Factor IXa; D015951:Factor Xa