Immunocytological studies in a case of Bruton's disease.
Immunopathological findings in a case with infantile X-linked agamma globulinemia (Bruton's disease) are reported and compared to similar data from two cousins of the patient. Besides a severe decrease in B-lymphocytes in blood and lymph node, residual B-cells showed an almost total defect in Ig surface receptor expression. In addition, there was an unusual lymphocyte population which apparently exhibited E-rosette formation (i.e. T-cell characteristics) and phagocytosis. The data suggest that in Bruton's disease there may be a disturbance of the T-cell system besides the well known B-cell deficiency.
D000361:Agammaglobulinemia / Q000235:genetics / Q000276:immunology*; D001402:B-Lymphocytes; D002648:Child; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D010587:Phagocytosis; D012397:Rosette Formation; D013601:T-Lymphocytes; D014960:X Chromosome