title: Negative pion irradiation of mammalian cells. III. A comparative analysis of DNA strand breakage, repair and cell survival after exposure to pi-mesons and X-rays.
abstract: The yields of immediate and residual breaks in DNA of X- and peak pion irradiated Chinese hamster cells were measured by hydroxylapatite chromatography in order to investigate the r.b.e. of immediate break production and the relation between residual breaks and survival in the same low dose range of up to 10 Gy. A linear dose response for immediate break induction was observed with an r.b.e. of 0.37 for peak pions, whereas the formation of residual breaks showed a linear-quadratic dose dependence for both types of radiation. The dose-effect curves of residual break can directly be correlated with the corresponding survival curves for both radiation types used indicating that residual breaks are lethal events (most probably unrepaired double strand breaks) formed in this low dose range by single- and multi-hit interactions. Despite their lower efficiency in formation of immediate breaks peak pions produce more residual breaks per dose than X-rays.
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000528:radiation effects*; D004260:DNA Repair; D004601:Elementary Particles; D005347:Fibroblasts / Q000502:physiology / Q000528:radiation effects; D009691:Nucleic Acid Denaturation; D014965:X-Rays
chemical_list: D004247:DNA