Hypophysectomy exerts a radioprotective effect on frog lens.
Exposure to X-rays usually causes cataracts in frogs. These cataracts are always preceded by misalignment of the structures called meridional rows (MR). When cell division is completely halted by hypophysectomy, however, irradiation no longer disturbs the orientation of the MR. Since the MR are the structures formed as lens epithelial cells differentiate into lens fibres it is reasonable to propose that radiocataractogenesis depends upon a mitosis-driven formation of pathological fibres from epithelial cells that have been rendered abnormal by exposure to X-rays.
D000818:Animals; D001001:Anura; D002386:Cataract / Q000473:pathology / Q000517:prevention & control; D007016:Hypophysectomy; D007908:Lens, Crystalline / Q000473:pathology / Q000528:radiation effects*; D008938:Mitosis; D011835:Radiation Protection; D011894:Rana pipiens