Anti-self receptors. III. Lack of allelic exclusion and thymic epithelium dependence of H-2L-region-restricted receptors on lymphocytes.
Murine thymocytes and peripheral lymphocytes bind autologous erythrocytes via H-2L-region-restricted receptors. After inhibiting autorosetting with different erythrocyte sonicates the specificity of these anti-self receptors was examined in F1 hybrid and chimaeric mice. Most F1 lymphocytes simultaneously expressed receptors against both parental haplotypes. Furthermore, analysis of lymphocytes from allogeneic and semi-allogeneic chimaeras clearly demonstrated that radioresistant elements in the recipient thymus did not modify the haplotype specificity of the receptors on donor-derived lymphocytes.
D000483:Alleles; D000818:Animals; D004848:Epithelium / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D006183:H-2 Antigens; D006238:Haploidy; D051379:Mice; D008815:Mice, Inbred Strains; D011828:Radiation Chimera; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
D006183:H-2 Antigens