Infections and antibiotic prophylaxis in the fulgurated rat bladder.
A model is described for establishing infection in a fulgurated rat bladder. Persistence of bacteriuria was dependent upon the size of the bacterial inoculum. Infection in an injured bladder exposed to a single predictable bacterial inoculum may be prevented by a single dose of antibiotic. The appropriate timing of antibiotic administration varies with the infecting organism.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000150:complications / Q000517:prevention & control*; D002437:Cefazolin / Q000627:therapeutic use; D004556:Electric Injuries / Q000150:complications; D004927:Escherichia coli Infections / Q000150:complications / Q000517:prevention & control; D011552:Pseudomonas Infections / Q000150:complications / Q000517:prevention & control; D051381:Rats; D014031:Tobramycin / Q000627:therapeutic use*; D001743:Urinary Bladder / Q000293:injuries*; D001745:Urinary Bladder Diseases / Q000150:complications / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D002437:Cefazolin; D014031:Tobramycin