[Oxygen-dependent influence of lipopolysaccharide endotoxin on polymorphonuclear leukocytes (author's transl)].
In in vitro experiments the effect of bacterial endotoxin (Lipopolysaccharide E. coli O 26 :B 6) on the ingestion, NBT reduction, and the formation of cytoplasmic vacuoles of polymorphonuclear leukocytes in the atmosphere of 21 vol-% O2 and 99.9 vol-% N2, respectively, was tested. High concentrations of endotoxin in O2-atmosphere cause an inhibition of the functions and a stimulation of vacuole formation, N2 atmosphere shows these effects of endotoxin on the ingestion and vacuole formation, if at all, in a lesser degree. These results show that endotoxin in high concentrations possibly causes an auto-oxidation of the polymorphonuclear leukocytes. This interpretation of the results is in accord with findings of other authors.
D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000473:pathology; D010100:Oxygen; D014617:Vacuoles
D004731:Endotoxins; D010100:Oxygen
O2-abhängige Wirkungen von Lipopolysaccharid-Endotoxin auf neutrophile Granulozyten.