title: [Effect of rimazolium (Probon) on biotransformation reactions in the rat].
abstract: Rimazolium inhibits ethylmorphine-N-demethylation and ethoxycoumarin-O-deethylation by rat liver homogenate when added in vitro in dependence on reaction differently, but marked effects are observed with high concentrations only (10(-3) mol). Both reactions are inhibited after administration of a high sedative dose (180 mg/kg) by 30-40%, after a non-sedative dose no inhibition could be observed. After a 4 d treatment both reactions were not influenced when investigated 24 h after the last administration, the induction by phenobarbital is inhibited in case of ethylmorphine-N-demethylation by rimazolium, but increased in case of ethoxycoumarin-O-deethylation.
mesh_terms: D015660:7-Alkoxycoumarin O-Dealkylase; D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D005037:Ethylmorphine-N-Demethylase / Q000037:antagonists & inhibitors; D006591:Hexobarbital / Q000494:pharmacology; D007700:Kinetics; D010105:Oxygenases / Q000037:antagonists & inhibitors; D011485:Protein Binding; D011744:Pyrimidinones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011744:Pyrimidinones; C100296:probon; D006591:Hexobarbital; D010105:Oxygenases; D015660:7-Alkoxycoumarin O-Dealkylase; D005037:Ethylmorphine-N-Demethylase
vernacular_title: Uber den Einfluss von Rimazolium (Probon) auf Biotransformationsreaktionen bei der Ratte.