Pseudonodular pattern of T-cell lymphoma.
The recently recognized mediastinal lymphoma of childhood is associated with early blood involvement and relentless, rapid progression. Component neoplastic cells characteristically exhibit diffuse growth patterns, convoluted nuclei, and T-cell markers. Occasionally, as in the present lymphoma, the tumors are composed of cellular nodules resembling the histologic pattern of nodular lymphocytic lymphoma. However, the nodules are derived from germinal centers and consequently do not represent the histologic pattern commonly associated with a more favorable prognosis.
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000097:blood / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology; D008479:Mediastinal Neoplasms / Q000097:blood / Q000473:pathology*; D008854:Microscopy, Electron; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*