B cell antibodies and crossmatching.
Over 200 cadaver donor transplants were crossmatched against T and B lymphocytes at 5 and 37 C. Of 54 positive B cell crossmatches, one-half had cold antibodies and one-half had warm antibodies. The 1-year transplant survival was 58% for B-cold-positive crossmatches and 42% for B-warm-positive crossmatches. The B-warm-positive crossmatches, when subdivided into those with strong HLA-DR antibodies showed a 27% 1-year transplant survival rate. We conclude that B cell-positive crossmatches with HLA-DR antibodies are deleterious and that those with cold anti-IgM antibodies may enhance graft survival.
D000042:Absorption; D000818:Animals; D000906:Antibodies; D001402:B-Lymphocytes / Q000276:immunology*; D002102:Cadaver; D003080:Cold Temperature; D006085:Graft Survival; D006650:Histocompatibility Testing; D006358:Hot Temperature; D006801:Humans; D016030:Kidney Transplantation; D011817:Rabbits
D000906:Antibodies