Immunologic tolerance after oral administration of reovirus: requirement for two viral gene products for tolerance induction.
We have demonstrated that reovirus type 1, but not type 3, generates serotype-specific immunologic tolerance for DTH responses following oral administration of UV-inactivated virus. As shown by adoptive transfer experiments, the tolerance is secondary to the generation of viral-specific suppressor T cells that are present in spleen and mesenteric lymph nodes. No tolerance was generated when live virus was administered orally. Using recombinant viral clones, it was found that 2 viral gene products were required for tolerance induction; serotype specificity is a property of the viral hemagglutinin (the product of the S1 dsRNA segment). The inability of type 3 reovirus to induce suppression following oral administration is a property of the mu 1C polypeptide (the product of the M2 dsRNA genome segment).
D000284:Administration, Oral; D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006389:Hemagglutinins, Viral / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007108:Immune Tolerance; D007116:Immunization, Passive; D007165:Immunosuppression Therapy; D012089:Mammalian orthoreovirus 3 / Q000276:immunology; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D014176:Protein Biosynthesis; D012087:Reoviridae / Q000235:genetics* / Q000276:immunology / Q000528:radiation effects; D013601:T-Lymphocytes / Q000276:immunology; D014466:Ultraviolet Rays
D006389:Hemagglutinins, Viral