[Reaction between syngeneic hematopoietic stem cells and lymphocytes in leukemic AKR mice].
The syngeneic donor-recipient model was used to examine the influence of T lymphocytes from AKR mice with spontaneous leukemia on colony-formation and differentiation of hemopoietic stem cells. It was shown that in the stage of the neoplastic process development, the cells of lymph nodes and the thymus inhibited the colony-forming capacity in all the three hemopoietic lines (erythroid, myeloid, megakaryocytic) of the syngeneic normal and autologous bone marrow. In the late stages of leukemia aggravated by generalized infection, T lymphocytes stimulated the exo- and endogenous growth of the granuloid colonies, changing the erythroid-myeloid index to 1:1-1:2.7.
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D002452:Cell Count; D005260:Female; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D007942:Leukemia, Experimental / Q000276:immunology* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D051379:Mice; D008806:Mice, Inbred AKR; D013154:Spleen / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*
Vzaimodeĭstvie singennykh stvolovykh krovetvornykh kletok i limfotsitov u leĭkoznykh mysheĭ linii AKR.