[The use of the Mongolian gerbil as a model for cerebrovascular involvement].
Mongolian Gerbils (Meriones Unguiculatus) are characterized by frequent anomalies of the circle of Willis. Their cerebral vessels lack arterial communication between the cerebral and vertebral system and they present an experimental model for cerebral ischemia. Among drugs which interfere with biogenic amine turn over, only 5HTP (75 mg/kg) decreased significantly the mean "stroke index". Vincamine (50 mg/kg) had the same effect.
D006916:5-Hydroxytryptophan / Q000627:therapeutic use; D000818:Animals; D002545:Brain Ischemia / Q000235:genetics* / Q000517:prevention & control; D002941:Circle of Willis / Q000002:abnormalities*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005849:Gerbillinae / Q000235:genetics*; D012376:Rodent Diseases / Q000235:genetics*; D014749:Vincamine / Q000627:therapeutic use
D014749:Vincamine; D006916:5-Hydroxytryptophan
Utilisation de la gerbille (Meriones unguiculatus) comme modèle d'étude d'atteinte vasculaire cérébrale.