Unusual case of progressive systemic sclerosis with onset in early childhood and following infectious mononucleosis.
A rare case of infantile progressive systemic sclerosis is reported. A Japanese girl suffered from infectious mononucleosis at the age of 1 year 3 months, and 5 months later she developed edema and sclerosis of the skin. She has been followed up for 4 years and now has grotesque features, with contractures of hands and feet due to advanced systemic sclerosis. The relationship between infectious mononucleosis and progressive systemic sclerosis is discussed.
D000505:Alopecia / Q000209:etiology; D001327:Autoimmune Diseases / Q000209:etiology; D001402:B-Lymphocytes / Q000276:immunology; D002675:Child, Preschool; D003286:Contracture / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D007244:Infectious Mononucleosis / Q000150:complications* / Q000276:immunology; D012595:Scleroderma, Systemic / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology