Suppression of thyroid proliferative response to exogenous TSH by prostaglandin synthesis inhibitors.
The influence of three different inhibitors of prostaglandin (PGs) synthesis (aspirin, indomethacin and hydrocortisone) on the proliferative effect of thyrotropin (TSH) has been investigated. It has been found that all these PGs synthesis inhibitors distinctly inhibit the proliferative response of thyroid follicular cells to TSH. This finding suggests an involvement of PGs in the proliferative action of TSH.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008940:Mitotic Index; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D051381:Rats; D013961:Thyroid Gland / Q000166:cytology* / Q000187:drug effects; D013972:Thyrotropin / Q000494:pharmacology*
D011448:Prostaglandin Antagonists; D013972:Thyrotropin; D001241:Aspirin; D003078:Colchicine; D006854:Hydrocortisone; D007213:Indomethacin