title: [State of the insular apparatus in rats with transplanted and induced tumors].
abstract: Observations were carried out in rats with transplantable Geren's carcinoma or sarcoma induced by 3,4-benz (a) pyrene. The contents of plasma immune-reactive insulin (IRI), the glucose tolerance and response of the insular apparatus to the glycemia level were found to change at all stages of the tumor growth. Most of animals had low levels of IRI in blood, the glucose tolerance was decreased. Some rats with Geren's carcinoma showed the signs of increased functioning of the insular apparatus. It was shown that disorders in the insular apparatus function in tumor-bearing animals were due to changing of its response to the level of glycemia.
mesh_terms: D000818:Animals; D001580:Benzopyrenes; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D005951:Glucose Tolerance Test; D007330:Insulin Antibodies / Q000032:analysis; D007515:Islets of Langerhans / Q000503:physiopathology*; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000503:physiopathology*; D051381:Rats; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000503:physiopathology; D013997:Time Factors
chemical_list: D001580:Benzopyrenes; D001786:Blood Glucose; D007330:Insulin Antibodies
vernacular_title: Sostoianie insuliarnogo apparata u krys pri perevivaemykh i indutsirovannykh opukholiakh.