Antibody-dependent cellular cytotoxicity mediated by subpopulations of human T lymphocytes: killing of human erythrocytes and autologous lymphoid cells.
The present study characterized the cytotoxic capabilities of human T lymphocyte subpopulations against human red blood cells (HRBC) and autologous lymphoid cells in an antibody-dependent cellular cytotoxicity (ADCC) assay. T cells bearing Fc receptors for immunoglobulin IgG (TG) were capable of lysis of antibody-coated HRBC and autologous lymphoid cells while T cells with surface Fc receptors for IgM (TM) displayed no ADCC activity TG-cell mediated ADCC could be inhibited by blockage of surface Fc receptors following treatment with aggregated Ig. Null cells and low-affinity E-rosette forming cells were also capable of similar ADCC activity against these targets.
D000328:Adult; D000920:Antibody-Dependent Cell Cytotoxicity; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011961:Receptors, Fc / Q000276:immunology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D013997:Time Factors
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011961:Receptors, Fc