title: alpha-1-Protease inhibitor phenotypes and serum concentrations in Thailand.
abstract: alpha-1-Protease inhibitor (A1PI) Pi phenotypes were determined in 429 individuals from Bangkok and 423 from the rural area of the northeast of Thailand by isoelectric focusing on thin-layer polyacrylamide gel. Variation was more marked in the Bangkok population. In the rural area, with an exclusively northeastern Thai population the Pi-alleles M, S and Z were detected. A1PI serum concentrations measured by electroimmunoassay were slightly higher in Thai than the values reported from European countries; children with PiM from rural areas had slightly higher A1PI serum concentrations than PiM children from Bangkok.
mesh_terms: D014644:Genetic Variation; D006801:Humans; D007122:Immunoelectrophoresis; D010641:Phenotype; D013785:Thailand; D000515:alpha 1-Antitrypsin / Q000235:genetics*
chemical_list: D000515:alpha 1-Antitrypsin