Self-reactive T cells. V. T cell-mediated suppression of B cell responsiveness to LPS.
The intravenous injection of polyclonally activated lymphoblasts elicited a proliferative T cell reaction in the spleens of syngeneic recipient mice. In the non-fractionated cell populations obtained from these spleens 6 days after lymphoblast transfer, the LPS-induced proliferation and differentiation of B cells in vitro was suppressed. This suppressive effect was mediated by T cells, as i) treatment with anti-Thy-1 antiserum plus complement restored responsiveness of B cells to LPS in the spleen cell population that had responded in vivo to a syngeneic lymphoblast graft, and ii) the responsiveness of B cells to LPS was not impaired in non-fractionated spleen cell populations of nu/nu mice injected with syngeneic lymphoblasts. The relationship of this nonspecific T suppressor cell activity to the previously described non-specific T helper cell activity for B cell activation is discussed.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001402:B-Lymphocytes / Q000166:cytology*; D003165:Complement System Proteins; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D007165:Immunosuppression Therapy; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation; D017710:Lymphocyte Transfusion; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D008819:Mice, Nude; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology*
D000961:Antilymphocyte Serum; D008070:Lipopolysaccharides; D003165:Complement System Proteins