title: Large scale detection of IgA deficient blood donors.
abstract: An automated technique using passive haemagglutination inhibition was developed on Groupamatic equipment for the screening of IgA deficient blood donors. Positive controls were also assayed by a manual haemagglutination inhibition test and solid-phase radioimmunoassay. Fourty-two blood donors totally deficient in IgA were detected in the systematic screening of 108,000 blood samples. Thirty-three were partially deficient and 2 other blood donors had an associated anti-IgA class-specific antibody. These donors now belong to a national panel of IgA deficient blood donors and their blood is used for the preparation of various IgA deficient blood components.
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis; D000918:Antibody Specificity; D001322:Autoanalysis; D001782:Blood Donors; D001803:Blood Transfusion; D004406:Dysgammaglobulinemia / Q000628:therapy; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D017098:IgA Deficiency; D007070:Immunoglobulin A / Q000032:analysis / Q000276:immunology; D011863:Radioimmunoassay
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007070:Immunoglobulin A