A sub-set of murine T lymphocytes forming rosettes with rabbit erythrocytes.
Lymphocytes from two murine strains AKR and CBA were found to form rosettes with rabbit erythrocytes. On comprehensive characterization of these cells by enrichment or selective depletion of constituent T- or B-lymphocytes, rosette forming ability was found to be an attribute of the subpopulation of Thy-1 +ve and Ig -ve cells. Further, the lymphocytes of this subset of T cells were found to be devoid of the receptor for C3 and a majority of them displayed sensitivity to hydrocortisone.
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology; D002478:Cells, Cultured; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007136:Immunoglobulins / Q000276:immunology; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008808:Mice, Inbred CBA; D011817:Rabbits / Q000276:immunology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000145:classification* / Q000276:immunology
D000954:Antigens, Surface; D007136:Immunoglobulins