title: [Analysis of lactate dehydrogenase isoenzymes in murine lymphocyte populations].
abstract: The pattern of lactate dehydrogenase isoenzyme has been examined for different murine lymphoid cell populations and for T and B lymphocyte populations. LDH-1, LDH-2, LDH-3, LDH-4 and LDH-5 were found in the thymus, LDH-3, LDH-4 and LDH-5 in the spleen, and LDH-4 and LDH-5 in lymph nodes. Enrichment of lymphocytes with T and B cells resulted in the appearance of LDH-4 and LDH-5 in T cell population, and of LDH-5 in B cell population. With the appearance of the autoimmune reaction, activity of LDH-5 in the thymus was seen to decrease. After the thymosin injection (4 fraction), activities of LDH-1, LDH-2 and LDH-3 diminished. A possible application of the LDH isoenzyme distribution pattern as a marker of T cell differentiation is discussed.
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000201:enzymology; D007109:Immunity; D066298:In Vitro Techniques; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008214:Lymphocytes / Q000201:enzymology*; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000201:enzymology / Q000276:immunology; D013601:T-Lymphocytes / Q000201:enzymology; D013947:Thymosin / Q000494:pharmacology; D013950:Thymus Gland / Q000201:enzymology / Q000276:immunology
chemical_list: D007527:Isoenzymes; D013947:Thymosin; D007770:L-Lactate Dehydrogenase
vernacular_title: Analiz izofermentov laktatdegidrogenazy v populiatsiiakh limfotsitov mysheĭ.