[Interactions between the platelets and the vessel wall. Part 1: Physiology (author's transl)].
The vessel wall plays an important role in the maintenance of balance between haemorrhage and thrombosis. The endothelial lining of a normal vessel wall is thrombo-resistant, in particular by virtue of prostacyclin, whilst the sub-endothelium with its collagen is thrombogenic. If the endothelium is pathologically or experimentally damaged, adhesion of the blood platelets becomes possible. This mechanism, presently studied at a molecular level itself, involves the Willebrand factor, the glycoproteins of the platelet membrane and constituents of the sub-endothelium which remain poorly defined. Platelet adhesion is responsible for cellular activation with the liberation of numerous intraplatelet constituents and synthesis of prostaglandins. Agregation between platelets involves complex biochemical phenomena which concern the platelet membrane and fibrinogen, contractile proteins and the cyclic AMP system, prostaglandins and ADP. The role of calcium in these different phenomena is very important.
D000244:Adenosine Diphosphate / Q000502:physiology; D001792:Blood Platelets / Q000378:metabolism / Q000502:physiology*; D001808:Blood Vessels / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology; D003094:Collagen / Q000502:physiology; D004727:Endothelium / Q000502:physiology; D011464:Epoprostenol / Q000378:metabolism; D005169:Factor VIII / Q000502:physiology; D006023:Glycoproteins / Q000502:physiology; D006801:Humans; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D011453:Prostaglandins / Q000378:metabolism / Q000502:physiology; D013928:Thromboxane A2 / Q000096:biosynthesis; D014841:von Willebrand Factor / Q000502:physiology
D006023:Glycoproteins; D011453:Prostaglandins; D014841:von Willebrand Factor; D013928:Thromboxane A2; D000244:Adenosine Diphosphate; D005169:Factor VIII; D003094:Collagen; D011464:Epoprostenol
Interactions plaquettes-paroi vasculaire. 1re partie: Physiologie.