title: New approaches for immunosuppression.
abstract: New approaches for experimental immunosuppression have been reviewed. These include the following: 1) cyclosporin A, a metabolite from fungus that suppresses multiplying but not resting T and B lymphocytes and can be used in pulsed manner with interspersed drug-free periods; 2) total lymphoid irradiation (transplantation tolerance in rats has been achieved by pretransplant radiation); 3) thoracic duct drainage, which is being revived following its demonstrated effectiveness in the treatment of some autoimmune disease; 4) hyperbaric oxygen (HBOX). We have found that HBOX 2 1/2 ATA for five hours daily depresses cell-mediated immunity in mice and that this can be reversed by intravenous administration of autologous macrophages.
mesh_terms: D000818:Animals; D003524:Cyclosporins; D004322:Drainage; D006801:Humans; D006931:Hyperbaric Oxygenation; D007111:Immunity, Cellular / Q000187:drug effects / Q000528:radiation effects; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation; D010456:Peptides, Cyclic / Q000627:therapeutic use; D013897:Thoracic Duct / Q000601:surgery; D014184:Transplantation, Homologous
chemical_list: D003524:Cyclosporins; D007166:Immunosuppressive Agents; D010456:Peptides, Cyclic