A comparison of agents for inducing parturition in mares in the pre-viable and premature periods of gestation.
Various regimens of prostaglandins, alone or followed by oxytocin, were given to induce parturition in mares during the pre-viable and premature periods of gestation and in near-term mares. The most successful method of induction was found to be 2 i.m. injections of 500 micrograms fluprostenol (Equimate: I.C.I.) at a 2-h interval followed (if necessary) by 10-20 i.u. oxytocin injected i.v. in 5 i.u. serial increments every 15-20 min. Peak concentrations of the prostaglandin metabolite (PGFM) in response to the inducing agents were shown to be associated with delivery at, but not before, 320 days of gestation. A radiolabelled study of [14C]fluprostenol distribution showed that fluprostenol was present in placenta, amnion, allantoic and amniotic fluid, and in foal plasma and liver.
D000818:Animals; D015237:Dinoprost; D005321:Extraembryonic Membranes / Q000378:metabolism; D005260:Female; D006736:Horses / Q000502:physiology*; D007751:Labor, Induced; D007743:Labor, Obstetric / Q000187:drug effects; D008186:Luteolytic Agents / Q000494:pharmacology*; D010121:Oxytocin / Q000494:pharmacology*; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011460:Prostaglandins F / Q000494:pharmacology*; D011461:Prostaglandins F, Synthetic / Q000378:metabolism / Q000494:pharmacology*; D011466:Prostanoic Acids / Q000097:blood
D008186:Luteolytic Agents; D011460:Prostaglandins F; D011461:Prostaglandins F, Synthetic; D011466:Prostanoic Acids; C019171:prostaglandin F-main urinary metabolite; C006326:fluprostenol; D010121:Oxytocin; D015237:Dinoprost