Evaluation of concentrated solutions of guaifenesin for equine anesthesia.
The pH, osmolality, stability, and bacteriostatic characteristics of 5%, 10%, and 15% solutions of guaifenesin were studied. In vitro and in vivo experiments were done to determine the hemolytic potential of the more concentrated solutions on equine blood, as compared with the recommended 5% solution. The primary objective was to determine whether more concentrated solutions could be used clinically. The secondary objective was to determine the optimal diluent (water, 0.9% saline, or 5% dextrose). It was concluded that a 10% solution of guaifenesin made in sterile distilled water was most suitable for clinical equine anesthesia. Such a preparation has reasonable storage qualities and does not induce clinically significant hemolysis.
D000758:Anesthesia / Q000662:veterinary*; D000818:Animals; D004926:Escherichia coli / Q000254:growth & development; D005260:Female; D006140:Guaifenesin / Q000008:administration & dosage* / Q000494:pharmacology; D006242:Haptoglobins / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis / Q000187:drug effects; D006736:Horses / Q000097:blood; D006863:Hydrogen-Ion Concentration; D008297:Male; D009994:Osmolar Concentration; D012996:Solutions; D013211:Staphylococcus aureus / Q000254:growth & development
D006242:Haptoglobins; D006454:Hemoglobins; D012996:Solutions; D006140:Guaifenesin