Viral antibody titres in HBs antigen-positive and -negative chronic active hepatitis.
A comparative study of antibody titres to nine common viruses has been carried out in hepatitis B surface (HBs) antigen-positive and -negative chronic active liver disease. The results show that increased titres of antibody to morbilli virus by complement fixation and to rubella by haemagglutination inhibition are found in HBs antigen-negative but not in HBs antigen-positive chronic active liver disease. There was a significant association of increased morbilli but not of rubella virus antibody titres with the presence of high-titre nuclear antibodies (ANA) but no association with smooth-muscle antibody or the presence of HLA-B8.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D000914:Antibodies, Viral / Q000032:analysis*; D002908:Chronic Disease; D003168:Complement Fixation Tests; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006505:Hepatitis / Q000276:immunology* / Q000382:microbiology; D006514:Hepatitis B Surface Antigens; D006801:Humans; D008107:Liver Diseases / Q000276:immunology* / Q000382:microbiology; D008297:Male; D008875:Middle Aged
D000974:Antibodies, Antinuclear; D000914:Antibodies, Viral; D006514:Hepatitis B Surface Antigens