title: Pupillary fatigue in myasthenia gravis.
abstract: By shining a narrow beam of light upon the pupillary margin, a sustained oscillation of pupil size or hippus, may be induced; the frequency of which is dependent upon the rate of conduction along the neuronal pathways subserving pupillary function. This manoeuvre has been carried out upon a series of twelve patients with myasthenia gravis, eleven of whom demonstrated a gradual diminution in oscillation frequency. This is compared with twelve control subjects, only one of whom demonstrated a significant decline in oscillation rate. The mean gradients were 0.0 +/- 0.4 cycles/min for the control subjects and -2.4 +/- 0.4 cycles/min for the patients with myasthenia. These gradients differ significantly p less than 0.0001. It is suggested that the pupillary reaction to light may be fatigued by exercising it at its maximum intrinsic rate in patients with myasthenia gravis.
mesh_terms: D000328:Adult; D000368:Aged; D005221:Fatigue; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000503:physiopathology*; D011680:Pupil / Q000502:physiology*; D013997:Time Factors