Adjuvant polyarthritis. V. Induction by N-acetylmuramyl-L-alanyl-D-isoglutamine, the smallest peptide subunit of bacterial peptidoglycan.
N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP), an apparently nonimmunogenic bacterial peptidoglycan-derived small peptide, was found to induce a polyarthritis the rat similar to that induced by Freund's complete adjuvant when injected in the form of an oil emulsion. An oil emulsion of its isomer, N-acetylmuramyl-L-alanyl-L-isoglutamine, which unlike MDP has no immunostimulatory activity, failed to induce the disease.
D000119:Acetylmuramyl-Alanyl-Isoglutamine; D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D001168:Arthritis / Q000139:chemically induced*; D001169:Arthritis, Experimental / Q000139:chemically induced*; D006020:Glycopeptides; D007428:Intradermal Tests; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010455:Peptides; D010457:Peptidoglycan; D051381:Rats; D011917:Rats, Inbred Lew
D000276:Adjuvants, Immunologic; D006020:Glycopeptides; D010455:Peptides; D010457:Peptidoglycan; D000119:Acetylmuramyl-Alanyl-Isoglutamine