[Mitogenic action of the murine serum factor to isologous aggregated immunoglobulins on splenic cell proliferation].
The authors studied the action of the mouse serum (MAAS) taken 6 days after isologous aggregated immunoglobulin injection on proliferation of spleen cells in vitro. MAAS was shown to exert a slight stimulant action on spleen cells at concentrations 1:40-1:60 with the peak reached after 48 hours. At these concentrations MAAS also potentiated cellular response to phytohemagglutinin (PHA) and concavalin A (Con A). The response to Con A was more pronounced, that suggests its reaction with Fc receptor-bearing cells as MAAS probably interacts with Fc receptors. The nature of the MAAS factor and its possible identity with the factor formed during the treatment of the cells in vitro with the aggregated immunoglobulin are discussed. The results obtained are in accordance with the earlier hypothesis that the role of MAAS in antitumour and grafit immunity might be connected with the mitogeneic activity of the serum.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D007376:Interleukin-2 / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008222:Lymphokines / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008934:Mitogens / Q000494:pharmacology*; D011971:Receptors, Immunologic / Q000187:drug effects; D013154:Spleen / Q000187:drug effects*; D013997:Time Factors
D007376:Interleukin-2; D008222:Lymphokines; D008934:Mitogens; D011971:Receptors, Immunologic; D004247:DNA
Mitogennoe deĭstvie faktora syvorotki k izologichnym agregirovannym immunoglonulinam myshi na proliferatsiiu kletok selezenki.