title: Acoustic responses after total destruction of the cochlear receptor: brainstem and auditory cortex.
abstract: Acoustically evoked neural activity has been recorded from the brainstem and auditory cortex of guinea pigs after complete destruction of the organ of Corti by the aminoglycosidic antibiotic amikacin. These responses to sound differ in important respects from the evoked potentials normally recorded from the auditory pathways. At the brainstem level they resemble the potentials reported by others after stimulation of the vestibular nerve.
mesh_terms: D000161:Acoustic Stimulation; D000583:Amikacin / Q000494:pharmacology; D000818:Animals; D001303:Auditory Cortex / Q000502:physiology*; D001933:Brain Stem / Q000502:physiology*; D003051:Cochlea / Q000502:physiology; D004567:Electrodes, Implanted; D005072:Evoked Potentials, Auditory; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects / Q000502:physiology; D009925:Organ of Corti / Q000187:drug effects / Q000502:physiology*; D012405:Round Window, Ear / Q000187:drug effects; D014726:Vestibular Nuclei / Q000502:physiology; D014722:Vestibule, Labyrinth / Q000502:physiology
chemical_list: D000583:Amikacin