Penetration of intravenously administered cefoxitin into the aqueous humor of inflamed human eyes.
Intravenous injections of cefoxitin (2-g doses for adults and 40 mg/kg of body weight doses for children) were administered 90 minutes to two hours before surgery. All nine eyes had anterior segment inflammation. Samples of aqueous humor removed during surgery showed a mean cefoxitin concentration of 6.22 micrograms/ml, almost three times the concentration reported in uninflamed eyes. The greater penetration may have been the result of a breakdown in the blood-aqueous barrier. There were no complications.
D000293:Adolescent; D000328:Adult; D001082:Aqueous Humor / Q000378:metabolism*; D002440:Cefoxitin / Q000008:administration & dosage / Q000378:metabolism*; D002648:Child; D009877:Endophthalmitis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D014605:Uveitis / Q000378:metabolism*
D002440:Cefoxitin