Evidence for a major cluster of lymphocyte differentiation antigens on murine chromosome 2.
The region of chromosome 2 between H-13 and H-3 has been shown to contain loci coding for a variety of other alloantigens, including Ly-4 and the locus coding for beta 2-microglobulin. Herein we show that Ly-6 and Ly-11 are coded for by genes in a segment of chromosome 2 adjacent to the H-3-H-13 region and that this segment of chromosome also contains the tightly linked loci coding for antigens Ala-1, DAG, H9/25, H-30, Ly-8, and ThB. In addition, at least one locus (and probably more) affecting susceptibility to leukemia induction is found within this gene cluster.
D000818:Animals; D000950:Antigens, Ly / Q000235:genetics*; D000954:Antigens, Surface / Q000235:genetics*; D002874:Chromosome Mapping; D005796:Genes; D008040:Genetic Linkage; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice
D000950:Antigens, Ly; D000954:Antigens, Surface