Somatic hybrids between a high NK-sensitive lymphoid (YACIR) and several low sensitive sarcoma or L-cell-derived mouse lines exhibit low sensitivity.
Mouse somatic cell hybrids between a high NK-sensitive lymphoma line (YACIR) and various sarcoma or L-cell-derived cell lines (all weakly sensitive) all exhibited low NK sensitivity. This was not due to a general resistance to cell-mediated lysis, since these mouse hybrids could be killed by in vitro-sensitized specific T cells. Alloantigens are usually codominantly expressed in somatic cell hybrids, whereas differentiation-related markers are usually suppressed. Because NK sensitivity was found to be suppressed, in contrast to the expression of alloantigens and tumor-associated antigens, we suggest that the target structure may be either a differentiation-related antigen or a differentiation-related "membrane property."
D000818:Animals; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D006183:H-2 Antigens; D006801:Humans; D006822:Hybrid Cells / Q000276:immunology*; D007519:Isoantigens; D007694:Killer Cells, Natural / Q000276:immunology*; D007739:L Cells; D008223:Lymphoma; D051379:Mice; D012513:Sarcoma, Experimental; D013601:T-Lymphocytes / Q000276:immunology
D006183:H-2 Antigens; D007519:Isoantigens