Effect of Fusarium toxins, T2-toxin and diacetoxyscirpenol on murine T-independent immune responses.
Trichothecenes mycotoxins, T2-toxin and diacetoxyscirpenol were investigated for their effect upon T-independent murine immune responses. Both anti-polyvinylpyrrolidone and anti-dinitrophenylficoll responses were enhanced by chronic administration of these toxins. Spleen cells from T2-toxin-treated animals revealed significantly less Thy 1.2+ cells than controls. Spleen cells from Fusarium crude extract-treated animals had a depressed response to phytohaemagglutinin (PHA) as compared with controls. Normal recipients given spleen cells from T2-toxin-treated mice were shown to generate approximately 50% less plaque-forming cells against sheep red blood cells than controls. It is suggested that these effects occur as a result of altered T suppressor-cell function.
D000818:Animals; D000917:Antibody Formation; D004306:Dose-Response Relationship, Immunologic; D005362:Ficoll / Q000031:analogs & derivatives / Q000276:immunology; D005670:Fusarium / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009183:Mycotoxins / Q000494:pharmacology; D011205:Povidone / Q000276:immunology; D012717:Sesquiterpenes / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology; D013605:T-2 Toxin / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology*; D014255:Trichothecenes / Q000494:pharmacology*
C031007:DNP-Ficoll; D009183:Mycotoxins; D012717:Sesquiterpenes; D014255:Trichothecenes; D005362:Ficoll; D011205:Povidone; D013605:T-2 Toxin; C001809:diacetoxyscirpenol