F-18-labeled 3-deoxy-3-fluoro-D-glucose for the study of regional metabolism in the brain and heart.
Glucose is the major physiological substrate of the brain and an important physiological substrate for the myocardium. [19F]fluoro-3-deoxy-glucose [3-FDG(F-18)] was studied to determine whether it is a suitable tracer for evaluating the metabolic function of the brain and myocardium. 3-FDG(F-18) was rapidly accumulated in the mouse myocardium (10-12% injected dose/g) and remained constant up to 120 min. Blood, liver, and lung activities exhibited a rapid accumulation of activity (4% injected dose/g) at 1 min, followed by elimination of activity up to 30 min (2% injected dose/g), and then remaining unchanged for a period of 120 min. The arterial blood curve in the dog was fit best by three exponential components (T 1/2 = 0.52 min, 2.75 min, and 142.8 min). Transverse-section images were obtained of the dog's brain and myocardium. From sequential two-dimensional images, a clearance half-time of 26.88 min was determined for the canine brain. Radiation doses for man were calculated from tissue distribution data for mice.
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism*; D004285:Dogs; D005461:Fluorine; D019788:Fluorodeoxyglucose F18; D006207:Half-Life; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D051379:Mice; D009206:Myocardium / Q000378:metabolism*; D011829:Radiation Dosage; D011849:Radioactive Tracers; D013329:Structure-Activity Relationship; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed / Q000379:methods
D003837:Deoxy Sugars; D011849:Radioactive Tracers; D019788:Fluorodeoxyglucose F18; D005461:Fluorine; D003847:Deoxyglucose