On the T cell hyperreactivity of NZB mice against H-2-identical cells. Evidence for primary response characteristics and an increased helper potential.
Experimental evidence presented in this paper suggests that the T cell hyperreactivity of NZB mice against H-2 identical target cells is a true primary response and not the consequence of an in vivo T cell autoimmune priming event. Based on additional data, we believe an elevated potential of T cell help to be present in NZB mice, which facilitates the observed hyperreactivity F1 hybrids of NZB and normal strains of mice inherited the capacity to hyperreact against H-2 identical cells in an H-2-unrestricted fashion. Because the hybrids tested possess both Qa-1 alleles--Qa-1b and Qa-1a--our experiments either indicate the existence of heterogeneity within the Qa-1b system or of an H-2-unrestricted response against additional target antigens. The T cell hyperreactivity might prove to be a valuable tool in further investigations of the pathomechanism of autoimmune disease.
D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology*; D006824:Hybridization, Genetic; D007114:Immunization; D007942:Leukemia, Experimental / Q000276:immunology; D051379:Mice; D008814:Mice, Inbred NZB / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D001323:Autoantibodies; D006183:H-2 Antigens