Immunosuppression in canine renal allografts using niridazole.
The immunosuppressive activity of niridazole in unmatched kidney allografts in nephrectomized dogs was studied. The drug alone was not effective, but improved survival when used with azathioprine and prednisolone or azathioprine alone. However, niridazole was toxic in dogs in the doses used (25 or 50 mg/kg/day).
D000818:Animals; D001379:Azathioprine / Q000494:pharmacology; D004285:Dogs; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D016030:Kidney Transplantation; D008297:Male; D009560:Niridazole / Q000494:pharmacology* / Q000633:toxicity; D011239:Prednisolone / Q000494:pharmacology; D014184:Transplantation, Homologous
D011239:Prednisolone; D001379:Azathioprine; D009560:Niridazole