title: Biochemical separation of interleukin 2.
abstract: Interleukin 2 (IL-2) is a class of T cell growth factors produced by T cells of a number of species. The unique growth-promoting properties of these molecules allow the development of antigen-specific effector T cell lines which can be used to analyze the molecular basis of lymphocyte interactions. A murine T cell tumor line has been identified as a source of IL-2. The purification and biochemical properties of murine IL-2 are described, and compared with rat and human Il-2.
mesh_terms: D000818:Animals; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006133:Growth Substances / Q000302:isolation & purification*; D006801:Humans; D007376:Interleukin-2 / Q000302:isolation & purification*; D007525:Isoelectric Focusing; D008222:Lymphokines / Q000302:isolation & purification*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D051381:Rats; D013601:T-Lymphocytes
chemical_list: D006133:Growth Substances; D007376:Interleukin-2; D008222:Lymphokines