Alcohol withdrawal: delayed distribution of intubated ethanol in rats having seizures.
Tail blood ethanol levels two hours after acute oral administration of ethanol to rats during withdrawal from chronic ethanol feeding were much lower in rats with previous seizures than in non-convulsing rats. Since ethanol elimination rates were similar, this suggests that in the convulsive state the distribution of ethanol to the periphery is severely inhibited.
D000284:Administration, Oral; D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors; D000818:Animals; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D051381:Rats; D012640:Seizures / Q000378:metabolism* / Q000503:physiopathology; D013375:Substance Withdrawal Syndrome / Q000378:metabolism* / Q000503:physiopathology
D000431:Ethanol; D000429:Alcohol Oxidoreductases