Circulating antigen-antibody complexes in onchocerciasis.
The presence of circulating antigen-antibody complexes in the sera of patients with onchocerciasis was investigated using the Clq and conglutinin solid-phase binding assays. Only 50% of patients' sera had demonstrable complexes, levels of complexes were unrelated to microfilarial load and specific anti-onchocercal antibody titres and results with the two tests for complexes were not correlated. Both IgM- and IgG-containing complexes were commonly involved but there was no correlation between the levels of complexes containing these isotypes. Evidence for the presence of IgE in complexes of sera from a minority of individuals was also obtained.
D000906:Antibodies / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000032:analysis*; D003166:Complement Activating Enzymes / Q000378:metabolism; D015922:Complement C1q; D003168:Complement Fixation Tests; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D008842:Microfilariae / Q000276:immunology; D009854:Onchocerca / Q000276:immunology; D009855:Onchocerciasis / Q000453:epidemiology / Q000276:immunology* / Q000469:parasitology; D013397:Sudan
D000906:Antibodies; D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007073:Immunoglobulin E; D015922:Complement C1q; D003166:Complement Activating Enzymes