Regulation and role of different macrophage-and granulocyte-inducing proteins in normal and leukemic myeloid cells.
It has previously been shown that there are different molecular forms of macrophage-and granulocyte-inducing (MGI) proteins; one form, MGI-l, induced the formation of colonies with differentiated cells from normal myeloblasts and another form, MGI-2, induced normal differentiation in MGI+D+ leukemic myeloblasts that no longer require MGI-l to form colonies. The present results indicate that MGI-2 can also induce differentiation (without inducing colony formation) in the normal cells, and that MGI-l induced MIG-2 in the normal but not in the leukemic cells. It is suggested from these results that MGI-2 is the differentiation-inducing protein for normal and leukemic cells whereas MGI-l is the growth-inducing protein that induces colony formation by the normal cells, and that induction of differentiation in the normal cell colonies is due to induction of MGI-2 by MGI-l.
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003115:Colony-Stimulating Factors / Q000494:pharmacology; D006098:Granulocytes / Q000187:drug effects / Q000473:pathology*; D007942:Leukemia, Experimental / Q000378:metabolism*; D008264:Macrophages / Q000187:drug effects / Q000473:pathology*; D051379:Mice; D009363:Neoplasm Proteins / Q000378:metabolism / Q000494:pharmacology*
D003115:Colony-Stimulating Factors; D009363:Neoplasm Proteins