Vitamin D deficiency rickets as a late complication of the short gut syndrome during infancy.
Four infants with less than 35 cm of jejunum and ileum remaining following neonatal operations and after being weaned from long-term total parenteral nutrition onto an "elemental" formula, developed the syndrome of vitamin D deficiency rickets at 9-15 mo of age. The diagnosis of rickets was confirmed by biochemical and radiographic findings. Serum 25 hydroxy vitamin D (25 OHD) values were significantly lower than normal and oral 25 OHD absorption studies indicated severe vitamin D malabsorption. This report emphasizes the importance of prospective assessment of all neonates having distal ileal resection to detect the early stages of vitamin D deficiency rickets.
D015652:25-Hydroxyvitamin D 2; D002792:Cholestyramine Resin / Q000627:therapeutic use; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood; D007082:Ileum / Q000002:abnormalities / Q000601:surgery; D007223:Infant; D007583:Jejunum / Q000002:abnormalities / Q000601:surgery; D008286:Malabsorption Syndromes / Q000150:complications*; D011183:Postoperative Complications; D012279:Rickets / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D012778:Short Bowel Syndrome / Q000150:complications* / Q000209:etiology
D006887:Hydroxycholecalciferols; D002792:Cholestyramine Resin; D015652:25-Hydroxyvitamin D 2