title: The timing of channel opening during miniature end-plate currents.
abstract: Many chemical transmitters act by opening channels with exponentially distributed life-times. We present a way to analyze a synaptic current in terms of its component channels. We can estimate the numbers and times of channel opening within the synaptic current. This approach is used to study miniature end-plate currents (m.e.p.c.s) at the frog neuromuscular junction. The results support the idea that some transmitter rebinds after dissociation from post-synaptic receptors, and suggest that the time of channel closing is related to the time at which acetylcholine leaves the receptor.
mesh_terms: D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D007700:Kinetics; D008433:Mathematics; D008564:Membrane Potentials; D009045:Motor Endplate / Q000502:physiology*; D009469:Neuromuscular Junction / Q000502:physiology*; D011894:Rana pipiens; D011950:Receptors, Cholinergic / Q000502:physiology
chemical_list: D011950:Receptors, Cholinergic; D000109:Acetylcholine