Cyclosporin-A inhibits accumulation of lymphocytes within lymph nodes.
The ability of cyclosporin-A (CS-A) to modify lymphocyte accumulation, seen in lymph nodes draining a site of antigen deposition, has been compared with the effect of other drugs known to affect lymphocytes and/or macrophages. CS-A markedly inhibited lymphocyte accumulation in a dose-related manner, whereas aspirin, BW755c (3 amino 1 [m (trifluoromethyl) phenyl] 2-pyrazoline) and hydrocortisone were without effect. Indomethacin produced inconclusive results. The time of CS-A administration was critical, the drug needing to be present before antigen inoculation, being ineffective if given 23 hr after antigen.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002465:Cell Movement / Q000187:drug effects; D003524:Cyclosporins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000494:pharmacology; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology* / Q000502:physiology; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew
D000893:Anti-Inflammatory Agents; D003524:Cyclosporins; C021650:hydrocortisone acetate; D006854:Hydrocortisone