Semisynthetic beta-lactam antibiotics. III. Cephalosporin derivatives in the furyl series. Chemical and microbiological properties.
The synthesis of a series of 7-acylamido cephalosporins having a substituted furyl moiety in the side chain is described. These new cephalosporins were examined in vitro for antibacterial activity and evaluated for resistance to inactivation by beta-lactamases.
D001419:Bacteria / Q000187:drug effects; D002510:Cephalosporinase / Q000378:metabolism; D002511:Cephalosporins / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D004355:Drug Stability; D006868:Hydrolysis
D002511:Cephalosporins; D002510:Cephalosporinase