[On the pharmacokinetics of tiaprofenic acid and its possible interactions with acetylsalicylic acid and aluminum hydroxide (author's transl)].
To clarify the question whether pharmacokinetic properties of tiaprofenic acid (presumable trade name Surgam) can be changed by simultaneous application of aluminum hydroxide or acetylsalicylic acid (ASA) a randomized study of 7 healthy volunteers was carried out. The results show that the bioavailability as well as the pharmacokinetic profile of orally administered tiaprofenic acid is not changed by the mentioned compounds.
D000536:Aluminum Hydroxide / Q000378:metabolism*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism*; D001241:Aspirin / Q000378:metabolism*; D001682:Biological Availability; D004347:Drug Interactions; D006801:Humans; D007700:Kinetics; D008297:Male; D011422:Propionates / Q000378:metabolism*; D013876:Thiophenes / Q000378:metabolism*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; D013876:Thiophenes; C021270:tiaprofenic acid; D000536:Aluminum Hydroxide; D001241:Aspirin
Zur Pharmakokinetik von Tiaprofensäure und zur Frage der Interaktion mit ASS und Aluminiumhydroxid.