Suppression of interstitial nephritis by auto-anti-idiotypic immunity.
Rats immunized with renal tubular antigens were protected from the development of interstitial nephritis by pretreatment with tubular antigen-reactive T lymphoblasts. Protected animals developed anti-idiotypic antibodies against idiotypes primarily within the antigen-binding region of monoclonal antitubular basement membrane antibodies. These studies extend the concept of auto-anti-idiotypic regulation to autoimmune disease, and they also provide an experimental basis for further efforts to develop biologically relevant mechanisms for attenuating the expression of other kidney diseases.
D000818:Animals; D000911:Antibodies, Monoclonal; D000941:Antigens; D001323:Autoantibodies / Q000096:biosynthesis*; D001327:Autoimmune Diseases / Q000276:immunology; D001485:Basement Membrane / Q000276:immunology; D001666:Binding Sites, Antibody; D007130:Immunoglobulin Idiotypes / Q000096:biosynthesis*; D007684:Kidney Tubules / Q000276:immunology; D009395:Nephritis, Interstitial / Q000276:immunology*; D011817:Rabbits; D051381:Rats; D011914:Rats, Inbred BN; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D000941:Antigens; D001323:Autoantibodies; D007130:Immunoglobulin Idiotypes