Human interleukin 2: production by both TG cells and other T cells.
We have investigated the production of interleukin 2 (IL-2) by human T cells after their stimulation by phytohaemagglutinin (PHA). T cells isolated by rosetting with sheep erythrocytes produced high levels of IL-2. Further separation of rosette-forming cells, according to the expression of Fc receptors for IgG, showed that TG and non-TG cells are equally able to produce IL-2. The release of IL-2 by TG cells did not require DNA synthesis or functional Rc gamma receptors, since positively selected TH cells produced IL-2, even though they lacked lymphoproliferative responses to PHA and antibody-dependent cell-mediated cytotoxicity.
D000920:Antibody-Dependent Cell Cytotoxicity; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G / Q000032:analysis; D007376:Interleukin-2 / Q000096:biosynthesis*; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000096:biosynthesis*; D010835:Phytohemagglutinins / Q000494:pharmacology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*
D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D007376:Interleukin-2; D008222:Lymphokines; D010835:Phytohemagglutinins; D004247:DNA