A B cell subpopulation binds to macrophages: this binding can be disrupted by T cells.
We have investigated the macrophage-binding properties of normal murine B cells and found that only a defined subpopulation of B cells can bind to macrophages. This subpopulation corresponds to the Lyb3--positive subpopulation. A population of T cells exists that disrupts this macrophage-B cell interaction. These findings are discussed in light of the demonstrated dependence on macrophages of several Lyb3+ cell functions.
D000818:Animals; D000941:Antigens; D001402:B-Lymphocytes / Q000145:classification*; D001665:Binding Sites; D001921:Brain / Q000276:immunology; D002450:Cell Communication; D002469:Cell Separation; D007153:Immunologic Deficiency Syndromes / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology; D013997:Time Factors
D000941:Antigens