Disseminated mycobacterial histiocytosis due to M. Fortuitum associated with helper T-lymphocyte immune deficiency.
Mycobacterial histiocytosis is a rare disease usually associated with haematological or immunological disorders. We report a fatal case caused by M. fortuitum infection showing the typical disseminated histiocytosis. Immunological investigations revealed impaired cellular immunity demonstrated by negative skin tests with different "recall-antigens", and in vitro an isolated defect of helper T-lymphocytes in the peripheral blood which in combination with hypergammaglobulinemia suggests a "lymphocyte and distribution syndrome".
D000328:Adult; D001344:Autopsy; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000150:complications / Q000209:etiology*; D008297:Male; D009165:Mycobacterium Infections, Nontuberculous / Q000150:complications / Q000473:pathology; D013601:T-Lymphocytes