Rainbow trout lymphoid organs: cellular effects of corticosteroids and anti-thymocyte serum.
Cellular populations were studied in lymphoid organs of rainbow trout. Kidney appeared to be the most important organ by the number of cells harvested. A high percentage of peroxidase positive cells was measured in kidney, spleen and blood. The use of cortisone and rabbit anti-thymocyte serum showed differences in ratio of sensitive cells from different organs. In fish treated with steroids, cell depletion was verified in each organ but histologic lesions were observed only in thymus. Rabbit anti-thymocyte serum was cytotoxic for the quasi-totality of thymocytes while it destroyed only a part of kidney, spleen and blood cells. No correlations could be made between steroid sensitive cells and anti-thymocyte serum sensitive cells.
D000375:Aging; D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology*; D002452:Cell Count; D003601:Cytotoxicity Tests, Immunologic; D003907:Dexamethasone / Q000031:analogs & derivatives* / Q000494:pharmacology; D007111:Immunity, Cellular / Q000187:drug effects; D007668:Kidney / Q000166:cytology / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000201:enzymology / Q000276:immunology; D008221:Lymphoid Tissue / Q000187:drug effects / Q000276:immunology*; D011817:Rabbits; D012487:Salmonidae / Q000276:immunology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000473:pathology; D014337:Trout / Q000276:immunology*
D000961:Antilymphocyte Serum; D003907:Dexamethasone; C018038:dexamethasone acetate