The effects of piridinol carbamate on hypercholesteremia and aortal damage produced by 5 days' application of Altman's diet to the rat.
The Altman's diet applied for 5 days in rats produces hypercholesteremia and aortal degeneration with breaks of continuity of elastic fibres and deposition of calcium salts. Piridinol carbamate depresses the serum cholesterol level and given in a dose 3 mg/kg prevents the damage of elastic fibres.
D000818:Animals; D001018:Aortic Diseases / Q000517:prevention & control*; D001161:Arteriosclerosis / Q000517:prevention & control*; D002219:Carbamates / Q000627:therapeutic use*; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004036:Diet, Atherogenic; D004872:Ergocalciferols / Q000008:administration & dosage; D006937:Hypercholesterolemia / Q000517:prevention & control*; D008297:Male; D011727:Pyridinolcarbamate / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors
D002219:Carbamates; D002791:Cholesterol, Dietary; D004872:Ergocalciferols; D011727:Pyridinolcarbamate