[Non-Hodgkin's malignant lymphoma: reliability of "typing" using cyto-enzymatic markers. Comparison with immunological markers (author's transl)].
Comparison between membrane markers and enzyme markers was made in 74 cases of non-Hodgkin's malignant lymphomas and a good correlation appears between both methods in order to distinct lymphomas into T and B origin. Enzyme markers are reliable and provide quickly made and easily interpretable documents. As far as T-lymphomas are concerned, three hydrolases namely acid phosphates e, acid esterase and B-glucuronidase give the same good results. As for B-lymphomas, a specific enzyme marker has to be found. Furthermore, typing of malignant lymphomas by enzymatic and/or immunologic methods appears to be quite better than from morphologic features such as convoluted or cleaved nuclei for example.
D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology; D004950:Esterases / Q000378:metabolism; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis* / Q000201:enzymology / Q000276:immunology; D008722:Methods; D013601:T-Lymphocytes / Q000276:immunology
D004950:Esterases; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D005966:Glucuronidase
Lymphomes malins non hodgkiniens: fiabilité du "typage" par les marqueurs cyto-enzymatiques. Comparaison avec les marqueurs immunologiques.