Pharmacokinetics of potassium clavulanate in combination with amoxicillin in pediatric patients.
Two dosages of a liquid suspension formulation of amoxicillin and potassium clavulanate were tested in 34 infants and children. The smaller dosage resulted in suboptimal plasma concentrations. With a greater dosage (3.3 mg of clavulanate per kg and 13.3 mg of amoxicillin per kg), the mean peak plasma concentrations were 1.6 micrograms clavulanic acid per ml and 4.9 micrograms amoxicillin per ml.
D000658:Amoxicillin / Q000008:administration & dosage / Q000378:metabolism*; D002648:Child; D019818:Clavulanic Acid; D004338:Drug Combinations; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D010405:Penicillinase / Q000378:metabolism; D013535:Suspensions; D013997:Time Factors; D047090:beta-Lactams / Q000008:administration & dosage / Q000378:metabolism
D004338:Drug Combinations; D013535:Suspensions; D047090:beta-Lactams; D019818:Clavulanic Acid; D000658:Amoxicillin; D010405:Penicillinase