Vestibular ototoxicity in children: a retrospective study of 52 cases.
We have carried out a study on 52 patients treated during childhood with potentially ototoxic drugs. The evaluation of vestibular function was carried out long after treatment. In most of the cases there was a parallelism between hearing and vestibular deficit. Manifest impairment of the vestibular function was demonstrated in 4 subjects, without remarkable hearing loss, who had previously been treated with streptomycin during childhood. Furthermore, in the case of 19 subjects, a considerable deambulation delay was noticed (in one case it revealed itself after the fourth year of life) which was attributable to a real injury to the vestibular structures. Finally, almost all examined subjects showed a dysfunction of equilibrium and a noticeable tendency to kinetopathy.
D000293:Adolescent; D000328:Adult; D000617:Aminoglycosides / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D006311:Hearing Disorders / Q000139:chemically induced*; D006801:Humans; D007759:Labyrinth Diseases / Q000139:chemically induced; D008297:Male; D012189:Retrospective Studies; D013307:Streptomycin / Q000009:adverse effects; D014724:Vestibular Function Tests; D014722:Vestibule, Labyrinth / Q000187:drug effects*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D013307:Streptomycin