Cord blood lymphocyte in vitro responses to influenza A antigens after an epidemic of influenza A/Port Chalmers/73 (H3N2).
Samples of cord blood from 46 deliveries were collected between 2 and 8 mo after an epidemic of influenza caused by A/Port Chalmers/73 (H3H2) virus. Of 10 samples with HAI antibody titers against A/Port Chalmers of 1:16 or greater, one had 2-mercaptoethanol-sensitive IgM class antibodies against the virus. Lymphocyte proliferative responses with the use of A/Port Chalmers antigens were increased in six of 46 samples. These results provide immunologic evidence that certain neonates have IgM antibodies and lymphocytes sensitized for influenza A virus. Our results suggest, but do not prove definitively, that influenza A/Port Chalmers virus infected the fetus prior to delivery.
D000914:Antibodies, Viral / Q000032:analysis*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005315:Fetal Diseases / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology; D008213:Lymphocyte Activation; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013601:T-Lymphocytes / Q000276:immunology*
D000914:Antibodies, Viral; D007075:Immunoglobulin M