Relationship between the tissue redox state potential and dak/dt changes of [K+]0 activity during k-strophantoside or acetylcholine induced contractures.
It was established that oxidosis evoked by methylene blue during k-strophantoside and acetylcholine contractures in skeletal muscle was accompanied by an increase in the changes of [K+]0 activity, while redosis evoked by ascorbate under the same conditions was accompanied by a decrease in the changes of [K+]0 activity. These changes in [K+]0 activity parallelled the alterations of contractures caused by oxidosis or redosis suggesting that changes in the [K+]0 transient play an important role in these phenomena.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D066298:In Vitro Techniques; D008751:Methylene Blue / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D011188:Potassium / Q000378:metabolism*; D011893:Rana esculenta; D013328:Strophanthins / Q000494:pharmacology
D013328:Strophanthins; C008240:K-strophanthoside; D000109:Acetylcholine; D001205:Ascorbic Acid; D011188:Potassium; D008751:Methylene Blue