title: Modification of aspartate before its condensation with dihydroxyacetone phosphate during quinolinic acid formation in Escherichia coli.
abstract: A crude enzyme preparation from a nadA mutant of Escherichia coli was used to catalyze the conversion of [14C]aspartic acid into a precursor of quinolinic acid, a key intermediate in the biosynthesis of nicotinamide adenine dinucleotide.
mesh_terms: D001224:Aspartic Acid / Q000378:metabolism*; D002474:Cell-Free System; D004099:Dihydroxyacetone Phosphate / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D005635:Fructosediphosphates / Q000378:metabolism; D006639:Histidine / Q000378:metabolism; D009154:Mutation; D009243:NAD / Q000096:biosynthesis; D011392:Proline / Q000378:metabolism; D011725:Pyridines / Q000378:metabolism*; D011805:Quinolinic Acids / Q000378:metabolism*; D014306:Trioses / Q000378:metabolism*
chemical_list: D005635:Fructosediphosphates; D011725:Pyridines; D011805:Quinolinic Acids; D014306:Trioses; D009243:NAD; D001224:Aspartic Acid; D006639:Histidine; D004099:Dihydroxyacetone Phosphate; D011392:Proline