title: [Serum 2'deoxyadenosine/adenosine deaminase ratio in clinical diagnosis].
abstract: In humans Adenosine Deaminase activity (ADA) differs in serum and tissues in pH optimum, Km, and relative substrate specificity. Thus, on the basis of a major or a minor activity on 2'Deoxyadenosine, a "serum type"enzyme can be distinguished from a "tissue type" enzyme. The examination of ADA or relative substrate specificity (ratio 2'Deoxyadenosine/adenosine deaminase) in the serum of 174 patients with variant pathology, revealed the occurrence of a "tissue type" enzyme in sera of acute Lymphoblastic Leukaemia patients.
mesh_terms: D000243:Adenosine Deaminase / Q000097:blood*; D004796:Clinical Enzyme Tests; D003839:Deoxyadenosines / Q000097:blood*; D006801:Humans; D007239:Infections / Q000175:diagnosis; D007938:Leukemia / Q000175:diagnosis; D009700:Nucleoside Deaminases / Q000097:blood*
chemical_list: D003839:Deoxyadenosines; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase
vernacular_title: Rapporto 2'deossiadenosina/adenosina deaminasi del siero nella diagnosi clinica.