title: Octanol and octanoate induced inhibition of the mechanical activity of isolated frog skeletal muscles.
abstract: Octanol (1 mM) or octanoate (10 mM) almost totally depress the contraction amplitude of directly stimulated muscles in a few minutes. Octanoate in a concentration of 2 mM/l decreases the contraction amplitude by 20% and retards the caffeine contracture. The ratio between twitch and tetanus is affected by octanol only. The results suggest that octanol and octanoate alter binding or releasing properties for Ca2+ of skeletal muscle cells.
mesh_terms: D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D002210:Caprylates / Q000494:pharmacology*; D004347:Drug Interactions; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects*; D000442:Octanols / Q000494:pharmacology*; D011893:Rana esculenta
chemical_list: D002210:Caprylates; D000442:Octanols; D002110:Caffeine; D002118:Calcium