title: [Evolutive aspects of Sharp's mixed connective tissue disease. 23 cases (author's transl)].
abstract: Among 23 patients with Sharp's disease, 14 initially had only polyarthritis, Raynaud's syndrome and anti-ribonucleoprotein antibodies. During a mean 5.6 years (range: 1-7 years) follow-up these 14 patients, 2 cases of pericarditis, 1 case of trigeminal neuralgia, 2 cases of nephropathy and 1 case of pulmonary arterial hypertension were observed. The 9 remaining patients had symptoms of multiple collagen disease. They were followed up for a mean of 4.3 years (range: 3-7 years) and 3 developed pericarditis. We discuss the prognostic significance of anti-DNA antibodies (7 cases) and low serum complement (3 cases) which, when combined, seem to be associated with severe visceral lesions.
mesh_terms: D000974:Antibodies, Antinuclear / Q000032:analysis; D001168:Arthritis / Q000150:complications; D003165:Complement System Proteins / Q000032:analysis; D004247:DNA / Q000276:immunology; D005500:Follow-Up Studies; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology; D008947:Mixed Connective Tissue Disease / Q000150:complications* / Q000276:immunology; D011379:Prognosis; D011928:Raynaud Disease / Q000150:complications; D012261:Ribonucleoproteins / Q000276:immunology
chemical_list: D000974:Antibodies, Antinuclear; D012261:Ribonucleoproteins; D003165:Complement System Proteins; D004247:DNA
vernacular_title: Aspects évolutifs de la connectivite mixte de Sharp. 23 observations.