Pollen-allergen IgE response in the inbred rat. Regulation of allergen P-IgE antibodies in high and low responders by suppressive factors.
Cyclophosphamide treatment (100 mg/kg) significantly increased the IgE response to plane-tree allergen P in low-responder strains of rats. A suppressive serum was obtained by injection of CFA in normal low-responder strains. The injection of this serum 2 days after cyclophosphamide treatment and 1 day prior to primary immunization, reversed the cyclophosphamide-enhanced IgE antibodies response without affecting the IgG2a levels. This effect is strain specific.
D000485:Allergens; D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D007114:Immunization; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D011058:Pollen; D011852:Radioallergosorbent Test; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D011920:Rats, Inbred WF; D013045:Species Specificity; D013997:Time Factors
D000485:Allergens; D007166:Immunosuppressive Agents; D007073:Immunoglobulin E; D003520:Cyclophosphamide