Combined chemotherapy--radiotherapy on spleen hypertrophy after C. parvum: combined treatment with 5-FU cyclophosphamide and radiation.
C. parvum (CP) acts as a powerful stimulant for cell proliferation in the normal spleen. CP, in combination with radiation or cytotoxic chemotherapeutic agents, interfered with their effect to a lesser or greater degree depending upon the sequence in which CP and the cytotoxic therapy was applied. In these experiments, cyclophosphamide (CY), 5-FU and radiation were studied singly or in combination during the resting or after CP-stimulation, and the effects of the different combinations of chemotherapy and radiotherapy determined. Interestingly, CY acted both as a stimulant and suppressant for the spleen growth response when combined with CP. This may contribute to the reported effectiveness of the combination used for therapy in certain antigenic tumour systems. Radiation had a strongly suppressive effect on spleen response to CP in any sequence studied.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000627:therapeutic use*; D006984:Hypertrophy; D007167:Immunotherapy; D051379:Mice; D008807:Mice, Inbred BALB C; D011425:Propionibacterium acnes; D013154:Spleen / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects
D000276:Adjuvants, Immunologic; D003520:Cyclophosphamide; D005472:Fluorouracil