S-100 protein in Langerhans cells, interdigitating reticulum cells and histiocytosis X cells.
S-100 protein was immunohistochemically demonstrated in the cells of cases of histiocytosis X such as eosinophilic granuloma, Hand-Schüller-Christian disease and Letterer-Siwe disease. Its presence was also shown in Langerhans cells of the epidermis and interdigitating reticulum cells in the lymph node, spleen and thymus. S-100 protein was not found in epithelioid cells in sarcoidosis, phagocytic macrophages, or dendritic reticulum cells in germinal centers. S-100 protein might be a new immunohistochemical marker for the Langerhans cells, interdigitating reticulum cells and histiocytosis X cells.
D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000166:cytology* / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009418:S100 Proteins / Q000032:analysis*; D012507:Sarcoidosis / Q000473:pathology; D012867:Skin / Q000166:cytology* / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology
D009419:Nerve Tissue Proteins; D009418:S100 Proteins