The effect of hydrocortisone on the metabolism of PGE2 in rat lungs.
Hydrocortisone pretreatment of male rats daily for five days (2 or 10 mg/kg, s.c.) had no significant effect on the total inactivation of prostaglandin E2 in isolated perfused rat lungs or on the activity of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase in the 100.000 x g supernatant fraction of homogenized lungs. Nor did pulmonary infusion of hydrocortisone (0.1 or 1 microM in the perfusion medium) have any effect on the metabolism of PGE2 in isolated rat lungs. The present study indicates that pulmonary inactivation of PGE2 is not changed by hydrocortisone in rat lungs.
D000818:Animals; D015232:Dinoprostone; D006854:Hydrocortisone / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011458:Prostaglandins E / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D011458:Prostaglandins E; D015232:Dinoprostone; D006854:Hydrocortisone