[Possibility of modulating morphine analgesia against a background of activation of serotonin- and GABA-ergic processes].
The analgesic effect of morphine in conditions of serotonin- and GABA-ergic activation was studied in experiments on male albino rats. The serotonin re-uptake blockers fluoxetin and citalopram (10 and 20 mg/kg) did not exert clear analgesic effect or did not potentiate morphine action in doses of 5 and 10 mg/kg. The GABA agonist muscimol (0.5--2 mg/kg) did not influence the pain reaction structure and did not enhance morphine-induced analgesia. The role of serotonin- and GABA-ergic processes in realization of the analgesic action of morphine is discussed.
D000700:Analgesics; D000818:Animals; D001572:Benzofurans / Q000008:administration & dosage*; D015283:Citalopram; D004347:Drug Interactions; D005473:Fluoxetine / Q000008:administration & dosage*; D008297:Male; D009020:Morphine / Q000008:administration & dosage*; D009118:Muscimol / Q000008:administration & dosage*; D010080:Oxazoles / Q000008:administration & dosage*; D010146:Pain / Q000517:prevention & control; D011437:Propylamines / Q000008:administration & dosage*; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000700:Analgesics; D001572:Benzofurans; D010080:Oxazoles; D011437:Propylamines; D005473:Fluoxetine; D015283:Citalopram; D009118:Muscimol; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D009020:Morphine
K voprosu o vozmozhnosti moduliatsii morfinovoĭ anal'gezii na fone aktivatsii serotonin- i GAMK-ergicheskikh protsessov.