[Increased sister-chromatid exchanges in fibroblasts from a del(13)-retinoblastoma patient (author's transl)].
Sister-chromatid exchanges were studied in fibroblasts from a child with del(13)-retinoblastoma. The skin biopsy was performed before the clinical onset of the tumor. The observed frequency of SCE, 19.65 per cell, was significantly increased as compared to that of a normal control, 14.68 per cell (t = 3.57, p < 0.001).
D002872:Chromosome Deletion; D002901:Chromosomes, Human, 13-15; D003434:Crossing Over, Genetic; D005134:Eye Neoplasms / Q000235:genetics*; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans; D007223:Infant; D008297:Male; D012175:Retinoblastoma / Q000235:genetics*; D012854:Sister Chromatid Exchange
Augmentation des échanges de chromatides dans les fibroblastes d'un enfant atteint de del(13)-rétinoblastome.