Antibacterial activity of cefuroxime in human bone.
Bone samples were taken at orthopaedic surgery from 12 patients, who had been treated with 2 doses of 750 mg cefuroxime by intravenous infusion. After grinding, extraction and assay by the agar diffusion method the levels of cefuroxime ranged between 0.4--1.9 micrograms/g bone. Using an electrophoretic method followed by microbiological assay, higher levels of cefuroxime were measured, possibly because of a diminution in the binding capacity of the bone.
D001424:Bacterial Infections / Q000517:prevention & control*; D001842:Bone and Bones / Q000378:metabolism* / Q000382:microbiology; D002444:Cefuroxime / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use*; D002511:Cephalosporins / Q000378:metabolism* / Q000627:therapeutic use*; D005270:Femur Head / Q000382:microbiology; D006622:Hip Prosthesis; D006801:Humans; D007263:Infusions, Parenteral; D008828:Microbiological Techniques; D013530:Surgical Wound Infection / Q000517:prevention & control*
D002511:Cephalosporins; D002444:Cefuroxime