Is the variation in the susceptibility of various species to atherosclerosis due to inborn differences in prostacyclin (PGI2) formation.
Species exhibiting a higher susceptibility to the development of atherosclerosis have a reduced prostacyclin (PGI2)-generation in the arterial wall, which differs in various parts of the vascular system. As the difference in PGI2-formation in various diseases is a generalized vascular effect, the changes can be detected in all vessels. This is a very important point for diagnostic purposes in humans.
D000367:Age Factors; D000818:Animals; D001011:Aorta / Q000378:metabolism; D001161:Arteriosclerosis / Q000209:etiology*; D001808:Blood Vessels / Q000378:metabolism*; D006224:Cricetinae; D011464:Epoprostenol / Q000096:biosynthesis*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D008647:Mesocricetus; D051379:Mice; D011453:Prostaglandins / Q000096:biosynthesis*; D011651:Pulmonary Artery / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D012737:Sex Factors; D012756:Sheep; D013045:Species Specificity; D014682:Vena Cava, Inferior / Q000378:metabolism
D011453:Prostaglandins; D011464:Epoprostenol