Effect of CBA/N xid on spontaneous production of antibodies to DNA in MRL/1 and NZB backcross mice.
We have used the CBA/N X-linked B-cell maturation defect (xid) as a probe to analyse the B-cell subset involved in spontaneous anti-DNA production in MRL/1 and NZB mice. The presence of xid in NZB offspring significantly suppressed anti-DNA production, whereas it did not suppress spontaneously produced antibody to DNA in MRL/1 offspring. These studies suggest that largely non-overlapping B-cell subsets are responsible for the spontaneous production of anti-DNA in MRL/1 and NZB mice.
D000818:Animals; D000974:Antibodies, Antinuclear / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D004247:DNA / Q000276:immunology*; D005260:Female; D007125:Immunogenetics; D007075:Immunoglobulin M / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008808:Mice, Inbred CBA; D008814:Mice, Inbred NZB; D008815:Mice, Inbred Strains; D014960:X Chromosome / Q000276:immunology
D000974:Antibodies, Antinuclear; D007075:Immunoglobulin M; D004247:DNA