Non-H-2 T-lymphocyte-mediated cytotoxicity after primary in vivo sensitization.
A low level of T-lymphocyte-mediated cytotoxic activity was demonstrated after primary in vivo immunization in an H-2-compatible strain combination (B10.D2--DBA2). This phenomenon was demonstrated in a second responder strain (BALB/c) and was thus shown not to be restricted to the B10.D2 genetic background. Results on F1 hybrid mice indicate that the M-locus determinant might be involved in this reaction. It is possible that it is involved in the afferent, efferent, or both limbs of the reaction.
D000818:Animals; D003433:Crosses, Genetic; D003602:Cytotoxicity, Immunologic; D006168:Guinea Pigs; D006183:H-2 Antigens; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D006183:H-2 Antigens