title: The ototoxic potential of netilmicin compared with amikacin. An animal study in guinea pigs.
abstract: The potential ototoxicity of netilmicin and amikacin was compared in guinea pigs. When the toxicity in animals is determined two parameters should be discussed: Dose related comparison of ototoxicity and a comparison related to the antibacterial potency. None of the netilmicin test groups (50-100 mg/kg body weight) showed a higher percentage of degenerated hair cells than the control group. Even the individual animals showed a sensory cell damage within the control animal range. With the antibacterial potency taken into account, a dose three times higher was given to the animals treated with amikacin than to those treated with netilmicin. The amikacin group of animals showed a high percentage of degenerated hair cells under these conditions.
mesh_terms: D000583:Amikacin / Q000633:toxicity*; D000818:Animals; D005839:Gentamicins / Q000633:toxicity*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects* / Q000648:ultrastructure; D006199:Hair Cells, Auditory, Inner / Q000187:drug effects; D006309:Hearing / Q000187:drug effects; D007612:Kanamycin / Q000031:analogs & derivatives*; D008854:Microscopy, Electron; D009428:Netilmicin / Q000633:toxicity*; D014722:Vestibule, Labyrinth / Q000187:drug effects
chemical_list: D005839:Gentamicins; D009428:Netilmicin; D007612:Kanamycin; D000583:Amikacin