Virus-immune cytotoxic T-cell activity following negative selection of alloreactive precursor lymphocytes.
Results obtained using negative selection protocols indicate that it is possible to obtain vaccinia-virus-specific killing of cells expressing H-2 types other than those encountered during physiologic development in thymus. This response has been found to be neither reciprocal for different H-2 types, nor identical for influenza and vaccinia viruses. Prior priming with virus apparently suppresses the capacity of T cells to be sensitized to H-2-different virus-infected cells.
D000818:Animals; D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D006183:H-2 Antigens; D006238:Haploidy; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013897:Thoracic Duct / Q000166:cytology*; D014616:Vaccinia virus / Q000276:immunology
D006183:H-2 Antigens; D011948:Receptors, Antigen, T-Cell