title: [Effect of rifampicin on body immunological reactivity].
abstract: The studies with 60 guinea pigs and 111 albino mice showed that the daily use of rifampicin for a prolonged period of time in an oral dose of 30 mg/kg for the guinea pigs and 20 mg/kg for the mice had a pronounced effect on the immunological reactivity of the host. The use of rifampicin for 3 months resulted in changed in the structure of the lymphoid organs and suppression of T-lymphocytes. It had an inhibitory effect on the development of the anaphylactic shock in response to the resolution dose of the foreign serum. The preliminary treatment of the mice with rifampicin for 2 months lowered the primary and to a greater extent the secondary immune response induced by the sheep red blood cells.
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced / Q000276:immunology; D000818:Animals; D006168:Guinea Pigs; D007113:Immunity, Innate / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D012293:Rifampin / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects; D013997:Time Factors
chemical_list: D012293:Rifampin
vernacular_title: Vliianie rifampitsina na immunologicheskuiu reaktivnost' organizma.