Studies on osteoporoses. XII. Effect of imidazoquinazolinones on experimental osteoporosis. A preliminary report.
In vivo neutron activation analysis was employed to determine total body calcium content in C3H/St(Ha) female mice. Ninety-nine percent of calcium is in bone and loss of calcium was used as an index of osteoporosis. Heparin (500 U/kg b.i.d.) treatment for three months resulted in significant osteoporosis. BL3459 and BL4160 (6 mg/kg i.m. q.d.) prevented this heparin induced osteoporosis. BL4160 appeared to be more effective than BL3459 in this regard but the difference was not statistically significant.
D000818:Animals; D002118:Calcium / Q000032:analysis; D005260:Female; D006493:Heparin / Q000008:administration & dosage; D051379:Mice; D008809:Mice, Inbred C3H; D009501:Neutron Activation Analysis; D010024:Osteoporosis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D011799:Quinazolines / Q000627:therapeutic use*
D011799:Quinazolines; C009709:6-methyl-1,2,3,5-tetrahydroimidazo(2,1-b)quinazolin-2-one hydrochloride; D006493:Heparin; D002118:Calcium