Gluten-sensitive enteropathy. I. The T-dependent anti-A-gliadin antibody response maps to the murine major histocompatibility locus.
We examined the genetic control of the murine humoral immune response to purified A-gliadin, a protein derived from wheat gluten, which is known to cause small intestinal disease in susceptible individuals. Studies with congenic and noncongenic inbred strains of mice revealed that the T-dependent humoral immune response to A-gliadin is under the control of genes mapping to the mouse major histocompatibility complex (MHC). These findings in mice establish a clear linkage between the MHC and the regulation of the immune response to a protein capable of causing human disease.
D000818:Animals; D000917:Antibody Formation; D002446:Celiac Disease / Q000276:immunology*; D005260:Female; D005903:Gliadin / Q000276:immunology*; D005983:Glutens / Q000009:adverse effects*; D006649:Histocompatibility Antigens / Q000235:genetics; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008819:Mice, Nude; D010940:Plant Proteins / Q000276:immunology*; D011817:Rabbits; D011863:Radioimmunoassay; D013601:T-Lymphocytes / Q000276:immunology*
D006649:Histocompatibility Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010940:Plant Proteins; D005983:Glutens; D005903:Gliadin