title: Charcot-Marie-Tooth's disease with severe trophic and sensory disorders. Study of a case following along a half a century with anatomical studies.
abstract: Plantar ulcers of neurological origin are known to be associated with several disorders, some of which may be familial. We present the case report together with the clinical and post-mortem data of a patient with peroneal muscular atrophy of the Charcot-Marie-Tooth type and plantar ulcers as a prominent feature. At least three other members of her family had Charcot-Marie-Tooth disease. The family pedigree is included. The discussion stresses the difference between patients with Charcot-Marie-Tooth disease with associated manifestations, bony destruction of the feet and plantar ulcers and patients with hereditary motor and hereditary sensory radicular neuropathies.
mesh_terms: D002607:Charcot-Marie-Tooth Disease / Q000150:complications / Q000235:genetics / Q000473:pathology*; D005260:Female; D005534:Foot Diseases / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D009132:Muscles / Q000473:pathology; D009134:Muscular Atrophy, Spinal / Q000473:pathology*; D010375:Pedigree; D012883:Skin Ulcer / Q000209:etiology; D013116:Spinal Cord / Q000473:pathology; D013497:Sural Nerve / Q000473:pathology