[Analysis of the escape of tumor P1798(SC) from immunologic control in hybrid mice (Balb/c X AKR)F1 (BAF1)].
Expression of tumoral antigens and their masking by sialic acids were studied. Tumour with greater content in sialic acid [P1798(sc)] can surpass the histocompatibility barrier. Furthermore, removal of sialic acid residues from membrane by neuramidase treatment results in a retarded or inhibited tumoral growth. These results suggest an antigenic masking by sialic acids. On the other hand, in the anti-P1798(sc) humoral response are involved two antigens, at least, also expressed by syngeneic hepatocytes and thymocytes, as demonstrated by cytotoxicity assays.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology; D006824:Hybridization, Genetic; D007111:Immunity, Cellular; D007157:Immunologic Surveillance; D008223:Lymphoma / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D009439:Neuraminidase / Q000494:pharmacology; D012794:Sialic Acids / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D012794:Sialic Acids; D009439:Neuraminidase
Análisis del escape del tumor P1798(SC) al control inmunológico en ratones híbridos (Balb/c X AKR)F1 (BAF1).