Comparative effects of some hydroxylated vitamin D metabolites on parathyrin secretion by dispersed rat parathyroid cells in vitro.
We have previously discussed the action of 1 alpha,25-(OH)2D3, (24R) 24,25-(OH)2 D3 and (25S) 25,26-(OH)2D3 on parathyrin secretion by isolated rat parathyroid cells. In this work, we have compared these effects with those obtained with 1 alpha-OH D3, 25-OH D3 and 1 alpha-OH D2. In decreasing order, the activities were: 1 alpha,25-(OH)2D3 greater than 1 alpha-OH D3 greater than (24R) 24,25-(OH)2D3 greater than 25-OH D3 greater than (25S) 25,26(OH)2D3 greater than 1 alpha-OH D2. The presence of two hydroxyl groups with one hydroxyl group in alpha position seems to have the higher activity to inhibit the parathyroid secretion. At least, the nature of the side chain conformation also plays a part upon the effect of PTH release.
D015650:24,25-Dihydroxyvitamin D 3; D000818:Animals; D002112:Calcifediol / Q000494:pharmacology; D002117:Calcitriol / Q000494:pharmacology; D004100:Dihydroxycholecalciferols / Q000494:pharmacology; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D008297:Male; D010280:Parathyroid Glands / Q000187:drug effects / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D010281:Parathyroid Hormone; D015650:24,25-Dihydroxyvitamin D 3; D002117:Calcitriol; D002112:Calcifediol; C008088:alfacalcidol