title: A study of three doses of ici 35 868 for induction and maintenance of anaesthesia.
abstract: Three doses (1.5, 2.0 and 2.5 mg kg-1) of diisopropyl phenol (ICI 35 868) were compared for induction and maintenance of anaesthesia in healthy females undergoing short gynaecological procedures. Induction of anaesthesia was smooth and rapid. Cardiovascular changes (which were dose-dependent) included a decrease in arterial pressure and an increase in heart rate. These changes were magnitudes comparable to those reported for other induction agents. Recovery from the effects of the drug was rapid and uneventful.
mesh_terms: D000328:Adult; D000771:Anesthesia, Intravenous / Q000009:adverse effects; D000777:Anesthetics / Q000008:administration & dosage* / Q000494:pharmacology; D001921:Brain / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D010636:Phenols / Q000008:administration & dosage* / Q000494:pharmacology; D015742:Propofol; D013997:Time Factors
chemical_list: D000777:Anesthetics; D010636:Phenols; D015742:Propofol