[New 5'-sulfurated nucleosides as inhibitors of the biosynthesis of polyamines].
The inhibitory effect of the deaminated analogs of S-adenosyl(5')-3-methylthiopropylamine on spermidine synthase (EC 2.5.1.16.) from E. coli, AdoMet decarboxylase (EC 4.1.1.50.) from human placenta and E. coli and AdoMet lyase (EC 3.3.1.-) from rat liver have been reported. 5'-isobutylthioadenosine, a new powerful antiproliferative drug has been assayed as substrate of MTA phosphorylase (EC 2.4.2.1). The apparent Km is 1,8x10(-5) M. The inhibitory effect of 5'-isobutylthiadenosine on AdoMet lyase and spermidine synthase was also demonstrated.
D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism; D002478:Cells, Cultured; D004926:Escherichia coli / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008190:Lyases / Q000378:metabolism; D009705:Nucleosides / Q000494:pharmacology*; D010920:Placenta / Q000378:metabolism*; D011073:Polyamines / Q000096:biosynthesis*; D051381:Rats; D011436:Spermidine Synthase / Q000378:metabolism
D009705:Nucleosides; D011073:Polyamines; D011436:Spermidine Synthase; D008190:Lyases; D002262:Carboxy-Lyases
Nuovi nucleosidi 5'-solforati quali inibitori della biosintesi delle poliammine.