[T and B immune systems in hereditary extrapyramidal disorders].
The per cent and absolute numbers of lymphocytes T and B were calculated in 37 patients with hereditary diseases of the nervous system (torsion dystonia, hepatolenticular degeneration, idiopathic tremor) and in 22 donors. Reactions of active and full spontaneous complement-induced formation of rosettes and B cell detection with surface immunoglobulin receptors were used for this purpose. In all hereditary diseases a reduction was found in the number of lymphocytes and a rise in the ability of the lymphocytes for complement-induced rosette formation. The obtained data should be evaluated, probably, as a secondary immunodeficiency state determined probably by metabolic disturbances playing an important role in the pathogenesis of hereditary nervous system diseases.
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology*; D001480:Basal Ganglia Diseases / Q000235:genetics / Q000276:immunology*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008231:Lymphopenia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
Układy T i B odporności w dziedzicznych chorobach pozapiramidowych.