Immunobiology of D-penicillamine.
D-penicillamine holds the key to a better understanding of autoimmunization and the pathogenesis of autoimmune disease. Analysis of its mode of action is complicated by its multiplicity of effects. In respect to anti-acetylcholine receptors and myasthenia gravis, the major effect may be at the level of immunoregulation and/or immunogenicity. Anti-striated muscle antibody is much more common and is influenced by the HLA antigen of the patient. Thus, HLA-linked immune response genes may be involved.
D000818:Animals; D000941:Antigens / Q000276:immunology; D001323:Autoantibodies / Q000096:biosynthesis; D001327:Autoimmune Diseases / Q000139:chemically induced; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D051379:Mice; D010396:Penicillamine / Q000009:adverse effects / Q000276:immunology*; D011817:Rabbits; D051381:Rats; D011946:Receptors, Antigen / Q000145:classification; D013489:Suppression, Genetic / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects
D000941:Antigens; D001323:Autoantibodies; D006680:HLA Antigens; D011946:Receptors, Antigen; D010396:Penicillamine