Somatomedin B: mitogenic activity derived from contaminant epidermal growth factor.
The mitogenic effect of somatomedin B on human cultured glial cells was neutralized by the addition of antibodies to mouse epidermal growth factor. Somatomedin B contained epidermal growth factor--like activity, competing for binding to the epidermal growth factor receptor. It is concluded that contaminating epidermal growth factor may explain the entire mitogenic activity of somatomedin B.
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D009457:Neuroglia; D010455:Peptides / Q000494:pharmacology*; D013002:Somatomedins / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D006133:Growth Substances; D010455:Peptides; D013002:Somatomedins; D004815:Epidermal Growth Factor; C016756:somatomedin B