[Microbiological transformation of cephalosporin C].
Bacteria and actinomycetes were screened for finding organisms that produced enzymes transforming cephalosporin C. Different bacteria were found to be capable for producing enzymes that degraded cephalosporin; actinomycetes possessed this capability to a lesser extent. The transformation of cephalosporin was catalyzed by beta-lactamase and acetyl esterase. One and the same culture could synthesize the both enzymes simultaneously; their activities and proportion depend on the conditions of cultivation. The production of enzymes degrading cephalosporin in bacteria seems to be a trait typical of a species or a strain.
D000115:Acetylesterase / Q000378:metabolism; D001419:Bacteria / Q000201:enzymology*; D001711:Biotransformation; D002511:Cephalosporins / Q000378:metabolism*; D003470:Culture Media; D006868:Hydrolysis; D013045:Species Specificity; D001618:beta-Lactamases / Q000378:metabolism
D002511:Cephalosporins; D003470:Culture Media; D000115:Acetylesterase; D001618:beta-Lactamases
Izuchenie mikrobiologicheskoĭ transformatsii tsefalosporina C.