[The NBT-PABA test in the diagnosis of exocrine pancreatic insufficiency (author's transl)].
The NBT-PABA test, an oral pancreatic function test, was performed in 67 patients with proven chronic pancreatitis (secretin pancreozymin test or intraoperatively) and was pathological in 60 (89.6%). Prolongation of urinary collection period from 6 to 9 hours did not improve the diagnostic value. In comparison with the NBT-PABA test the sensitivity of trypsin and chymotrypsin determination in stool was 40.6% and 62.2%, respectively. In severe exocrine pancreatic insufficiency when pathological fecal fat excretion was demonstrable (steathorrhea) the accuracy of fecal enzyme determination was clearly higher (59.1% and 91.8%, respectively). Thus the NBT-PABA test is an alternative diagnostic tool for exocrine pancreatic insufficiency when the secretin-pancreozymin test, and fecal enzyme and fecal fat determination are too complicated. However, as intact absorption of NBT-PABA is possible, the test only provides a qualitative and limited quantitative evaluation of pancreatic function.
D010129:4-Aminobenzoic Acid; D000293:Adolescent; D000328:Adult; D000368:Aged; D062365:Aminobenzoates; D002766:Cholecystokinin; D002908:Chronic Disease; D010188:Exocrine Pancreatic Insufficiency / Q000175:diagnosis*; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D008055:Lipids / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010186:Pancreatic Function Tests; D010195:Pancreatitis / Q000175:diagnosis; D012633:Secretin; D062366:para-Aminobenzoates
D062365:Aminobenzoates; D008055:Lipids; D062366:para-Aminobenzoates; D012633:Secretin; D002766:Cholecystokinin; D010129:4-Aminobenzoic Acid
Der NBT-PABA-Test in der Diagnostik der exokrinen Pankreasinsuffizienz. Ein Vergleich mit dem Sekretin-Pankreozymin-Test, den Stuhlenzym-Bestimmungen und der quantitativen Stuhlfett-Analyse.