title: Hereditary factors in the craniofacial morphology of Angle's Class II and Class III malocclusions.
abstract: We attempted to assess the role of heredity in the development of Angle's Class II and Class III malocclusions by comparing craniofacial morphologic differences between parents with Class II offspring and those with Class III offspring and by analyzing the parent-offspring correlations within each Class II and Class III malocclusion group. Lateral and frontal roentgenographic cephalograms were obtained for ninety-six patients with Class II malocclusion, 104 patients with Class III malocclusion, and their respective parents. Mean cephalometric profile diagrams were superimposed between the two groups of parents as well as between their offspring. Within the two groups, the parent-offspring correlation coefficients were computed for nineteen variables connecting cephalometric landmarks. The differences in the craniofacial complex were evident in the two groups of parents as well as in their offspring. High correlation coefficient values were seen between parents and their offspring in the Class II and Class III groups. Thus, there appears to be a strong familial tendency in the development of Class II and Class III malocclusions. We conclude that the hereditary pattern must be taken into consideration in the diagnosis and treatment of patients with these classes of malocclusion.
mesh_terms: D000293:Adolescent; D000328:Adult; D002508:Cephalometry; D002648:Child; D005145:Face / Q000033:anatomy & histology; D005260:Female; D006801:Humans; D008297:Male; D008310:Malocclusion / Q000235:genetics* / Q000473:pathology*; D008312:Malocclusion, Angle Class II / Q000473:pathology*; D008313:Malocclusion, Angle Class III / Q000235:genetics* / Q000473:pathology; D012886:Skull / Q000033:anatomy & histology