Association of B cell alloantigen with juvenile onset diabetes mellitus in the Japanese.
Sixty-four Japanese insulin dependent juvenile onset diabetes mellitus (JOD) were studied in relation to HLA-A, B, and DR. Significant deviations were observed. HLA-Bw54 was increased (PF = 49.2%, RR = 6.4) and HLA-B5 was decreased (PF = 7.9%, RR = 0.19). Using radioimmunoassay, two HLA-DR antigens were investigated. Hon 7 antigen, so-called MT3 (WIA4x7), which has linkage disequilibrium between HLA-BW54, is highly associated (PF = 96.9%, RR = 27.8) with JOD found in the Japanese.
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology*; D008040:Genetic Linkage; D006680:HLA Antigens; D006650:Histocompatibility Testing; D006801:Humans; D007519:Isoantigens; D007564:Japan; D011863:Radioimmunoassay
D006680:HLA Antigens; D007519:Isoantigens