[Prevention of postoperative Candida endomycoses. Candida colonization and Candida antibodies in patients undergoing cardiovascular surgery].
Of 23 patients undergoing heart surgery and 11 patients undergoing vessel surgery 26 (76%) are colonized with Candida albicans on admission to hospital. Postoperatively the yeast quantity in the mucocutaneous flora remains nearly constant in both groups. However, during the 2nd-3rd week after operation 21 heart surgery patients and 3 vessel surgery patients developed a significant rise in Candida antibodies in the Ig-classes G, M and/or A. Eight weeks after surgery the IgM-antibodies once again reached preoperative values in 14 of 16 patients; the IgG- and IgA-antibodies, however, tend to be of longer persistent. The antibody response is most probably due to Candida invasion via tracheal traumatization by prolonged intubation. Persistent elevation of IgM-antibodies indicates preventive antifungal therapy.
D000328:Adult; D000368:Aged; D000908:Antibodies, Fungal / Q000032:analysis*; D002177:Candidiasis / Q000175:diagnosis / Q000276:immunology / Q000517:prevention & control*; D002318:Cardiovascular Diseases / Q000601:surgery*; D001026:Coronary Artery Bypass; D004696:Endocarditis / Q000276:immunology / Q000517:prevention & control; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*
D000908:Antibodies, Fungal; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Untersuchungen zur Prävention postoperativer Candida-Endomykosen. Candida-Besiedelung und Candida-Antikörper bei Patienten mit herz- und gefässchirurgischen Eingriffen.