Decreased central serotonin function in hypothyroidism.
Male rats born of mothers kept on an iodide-free diet from day 15 of pregnancy up to day 4 post-delivery, were rendered hypothyroid by a daily s.c. injection of methimazole, 20-25 mg/kg from day 1 up to day 30 of age. Two days after the last injection, euthyroid and hypothyroid rats were given 220 mg/kg i.p. of L-5-hydroxytryptophan (5-HTP). The resulting behavioral syndrome was much less intense in hypothyroids, compared to euthyroids, thus suggesting a state of serotonergic hypoactivity.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002490:Central Nervous System / Q000503:physiopathology*; D005260:Female; D007037:Hypothyroidism / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011985:Receptors, Serotonin / Q000502:physiology; D012701:Serotonin / Q000502:physiology*; D013997:Time Factors; D014284:Triiodothyronine / Q000494:pharmacology
D011985:Receptors, Serotonin; D014284:Triiodothyronine; D012701:Serotonin; D006916:5-Hydroxytryptophan