title: Removal of uremic toxins and regeneration of hemofiltrate by a selective dual hemofiltration artificial kidney (SEDUFARK) system.
abstract: A new system for the treatment of patients with end-stage renal failure has been developed. The SElective DUal Filtration ARtificial Kidney (SEDUFARK) is based on a dual filtration technique combined with low flow dialysis. Primary hemofiltrate containing large molecular weight substances is regenerated through a second filter followed by dialysis before the fluid containing essential substances of low molecular weight is returned to the patient. The ability of SEDUFARK to purify blood from uremic patients has been evaluated using a human macrophage assay system. Uremic plasma post SEDUFARK treatment was significantly less toxic than matched pre treatment plasma and the SEDUFARK regeneration system was found superior to conventional hemofiltration treatment.
mesh_terms: D001769:Blood; D002176:Candida albicans; D003470:Culture Media; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D007688:Kidneys, Artificial; D008264:Macrophages / Q000166:cytology; D008970:Molecular Weight; D010587:Phagocytosis; D014462:Ultrafiltration / Q000379:methods*; D014511:Uremia / Q000097:blood / Q000628:therapy*
chemical_list: D003470:Culture Media