Plasma norepinephrine variations with dietary sodium intake.
Plasma catecholamine and renin activity levels were measured across a range of dietary sodium intakes (10--300 mEq/day) in 20 normal male volunteers. Supine plasma norepinephrine levels presented a triphasic pattern in relation to urine sodium, whereas epinephrine levels were not significantly altered by sodium intake, and renin showed the well-known hyperbolic relationship to urine sodium excretion. Highest supine norepinephrine values occurred at low salt intakes, the lowest when sodium excretion was between 100 and 180 mEq/day, and intermediate when sodium excretion was greater than 180 mEq/day. These findings show that sodium intake is an important consideration in the interpretation of plasma norepinephrine levels.
D000328:Adult; D004039:Diet, Sodium-Restricted; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000008:administration & dosage* / Q000502:physiology* / Q000652:urine
D012964:Sodium; D012083:Renin; D009638:Norepinephrine