Rotational behavior induced by unilateral electrical stimulations of nigro-striatal dopamine neurons: modification by low doses of apomorphine.
Unilateral electrical stimulation of nigro-striatal dopamine axons produced marked turning contralateral to the stimulated side. Iterative stimulation led to a progressive increase of this response, followed by a definitive decrease associated with lesions of dopamine neurons. A low dose of apomorphine (25 micrograms/kg) slightly modified the time course and intensity of this response. On the contrary, in rats with a lesioned contralateral nigro-striatal system, low doses of apomorphine (6.25-50 micrograms/kg) markedly depressed contralateral turning whereas a higher dose (150 micrograms/kg) no longer depressed it. These results are discussed with regard to the dopamine autoreceptors.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D004558:Electric Stimulation; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008297:Male; D008474:Medial Forebrain Bundle / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects / Q000502:physiology*; D013378:Substantia Nigra / Q000502:physiology*
D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine