Anterior segment mesenchymal dysgenesis: probable linkage to the MNS blood group on chromosome 4.
Thirty-seven blood samples were analyzed for linkage from members of a single family with an anterior segment mesenchymal dysgenesis (ASMD1) with variable expressivity affecting members of at least six generations. Maximum-likelihood analysis for linkage between ASMD1 and 14 biochemical and serological markers in the family showed a probable linkage between ASMD1 and the MNS blood group on the long arm of chromosome 4 (Z = 2.36 at a recombination fraction of .09).
D002874:Chromosome Mapping; D002905:Chromosomes, Human, 4-5; D003317:Corneal Dystrophies, Hereditary / Q000235:genetics*; D003886:Descemet Membrane / Q000002:abnormalities; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008951:MNSs Blood-Group System / Q000235:genetics*; D008297:Male; D010375:Pedigree; D010641:Phenotype; D013577:Syndrome
D005819:Genetic Markers; D008951:MNSs Blood-Group System