The detection of carcinogen-induced sperm head abnormalities in mice.
The (CBA X BALB/c(F1 male mouse is sensitive to the induction of sperm-head abnormalities after exposure to a range of chemical mutagens and carcinogens. 8 carcinogens including ethionine and diethyl stilboestrol were correctly identified. 23 non-carcinogens and compounds of unknown carcinogenicity including a range of 13 substituted anilines and methionine did not induce sperm-head abnormalities. 4-Aminophenol induced an increase in sperm-head abnormalities. The utility of the procedure for identifying genotoxic compounds is discussed.
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005821:Genetic Techniques; D008297:Male; D051379:Mice; D009153:Mutagens; D013077:Sperm Head / Q000187:drug effects* / Q000473:pathology; D013094:Spermatozoa / Q000187:drug effects*
D002273:Carcinogens; D009153:Mutagens