Crossreactivity as a factor in the immune response to Salmonella typhimurium in CBA and BALB/C mice.
The immune response to Salmonella typhimurium was investigated in CBA and BALB/C mice, by an arithmetic Widal agglutination assay. High antibody titres were obtained in CBA and low titres in BALB/C mice after secondary immunisation. A rabbit antiserum raised against S. typhimurium was tested for agglutinating activity after absorption with spleen- and lymph-node cells obtained from unimmunised CBA or BALB/C mice. BALB/C cells consistently removed more anti-S. typhimurium antibodies than did CBA cells, whilst the quantities of Fc receptor-bearing cells were found to be similar in both strains when measured by the erythrocyte-antibody rosette technique. It is suggested BALB/C mice give a low antibody response because their cell-surface antigens crossreact to a greater degree with S. typhimurium than do CBA cell-surface antigens.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D000942:Antigens, Bacterial / Q000276:immunology*; D000954:Antigens, Surface; D003429:Cross Reactions; D007114:Immunization; D008198:Lymph Nodes / Q000166:cytology; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D012486:Salmonella typhimurium / Q000276:immunology*; D013154:Spleen / Q000166:cytology
D000914:Antibodies, Viral; D000942:Antigens, Bacterial; D000954:Antigens, Surface