The site of action of 2,4-dinitrophenol and salicylic acid upon the uncoupler-induced K+ efflux from non-metabolizing yeast.
Stimulation of K+ efflux from non-metabolizing yeast cells by 2,4-dinitrophenol or by salicylic acid occurs only after accumulation of the compounds into the cells, indicating that the site of action of the uncouplers is inside the cells. A correlation is found between the partition ratio of the lipophilic cation dibenzyldimethylammonium between cells and medium and the rate of K+ efflux.
D001692:Biological Transport / Q000187:drug effects; D008725:Bis-Trimethylammonium Compounds / Q000378:metabolism; D004140:Dinitrophenols / Q000378:metabolism / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D011188:Potassium / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000378:metabolism*; D012459:Salicylates / Q000378:metabolism / Q000494:pharmacology*
D008725:Bis-Trimethylammonium Compounds; D004140:Dinitrophenols; D012459:Salicylates; D011188:Potassium