Clinical experience with cold blood as the vehicle for hypothermic potassium cardioplegia.
Intermittent cold ischemic arrest was compared with hypothermic potassium cardioplegia using cold blood as the vehicle in two consecutive series of patients having isolated coronary bypass grafting. Between January 1, 1977, and June 30, 1977, 196 patients were operated on using cold ischemic arrest. The incidence of perioperative infarction was 14.3%, and mean total myocardial ischemia time was 42 +/- 1.2 minutes. From July 1, 1977, to June 30, 1978, there were 428 operations done using cold blood with potassium. The incidence of perioperative infarction was 5.6% (p less than 0.005), and the mean total myocardial ischemic time was 80 +/- 2.1 minutes. In the five years prior to this study, the incidence of perioperative infarction was constant at 13% while operative mortality was declining from 5 to 1% and the need for postoperative myocardial support was declining also. Use of cold blood potassium cardioplegia compared with cold ischemic arrest for myocardial protection during coronary artery operations has significantly reduced the incidence of perioperative infarction while doubling cross-clamp time.
D001219:Aspartate Aminotransferases / Q000097:blood; D001769:Blood; D001026:Coronary Artery Bypass / Q000401:mortality; D003402:Creatine Kinase / Q000097:blood; D006324:Heart Arrest, Induced / Q000379:methods*; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D007431:Intraoperative Complications / Q000517:prevention & control; D007770:L-Lactate Dehydrogenase / Q000097:blood; D009203:Myocardial Infarction / Q000201:enzymology / Q000517:prevention & control; D010477:Perfusion; D011183:Postoperative Complications / Q000517:prevention & control; D011188:Potassium / Q000008:administration & dosage
D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D011188:Potassium