The reaction of xenogeneic and monoclonal antisera with Reed-Sternberg cells.
Xenogeneic antisera have been prepared against human monocytes, B lymphocytes and T lymphocytes. The reactivity of these antisera against a variety of normal and neoplastic cells is described. Reed-Sternberg cells from three cases of Hodgkin's disease failed to react with xenogeneic anti-T and anti-monocyte sera, but reacted with an anti-B serum. A further three cases were examined with monoclonal antibodies. Negative results were obtained with monoclonal anti-T and positive results were given by monoclonal antibodies directed against DR and HLA antigens.
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006689:Hodgkin Disease / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007106:Immune Sera / Q000276:immunology*; D009000:Monocytes / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000949:Histocompatibility Antigens Class II; D007106:Immune Sera