Suppression of T lymphocyte proliferation during lymphoma growth in mice: role of PGE2-producing suppressor macrophages.
The suppressed T lymphocyte response occurring during lymphoma growth in mice was largely due to the generation of suppressor macrophages which released high amounts of prostaglandin E2 (PGE2). Based on these findings, the role of macrophage-derived PGE2 as a regulating and potentially immunosuppressive agent of the immune response is discussed.
D000818:Animals; D002364:Caseins / Q000494:pharmacology; D002469:Cell Separation; D003208:Concanavalin A / Q000494:pharmacology; D015232:Dinoprostone; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008213:Lymphocyte Activation; D008223:Lymphoma / Q000276:immunology*; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D011458:Prostaglandins E / Q000096:biosynthesis* / Q000494:pharmacology; D013154:Spleen / Q000166:cytology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*
D002364:Caseins; D007166:Immunosuppressive Agents; D011458:Prostaglandins E; D003208:Concanavalin A; D015232:Dinoprostone