title: Bilateral endogenous necrotizing scleritis due to Aspergillus oryzae.
abstract: A case of bilateral necrotizing scleritis due to Aspergillus oryzae is reported. The patient was a former addict of intravenous narcotics treated five years previously for meningitis due to the same organism. A seeding focus in the thoracic spine was eventually found. The patient responded well to combined local and systemic therapy with amphotericin B, flucytosine, and natamycin. This represents, to the best of our knowledge, both the first reported case of ocular disease due to this species of Aspergillus and of isolated scleral, nonintraocular involvement in endogenous oculomycosis.
mesh_terms: D000293:Adolescent; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications* / Q000188:drug therapy; D001236:Aspergillus oryzae / Q000302:isolation & purification; D002648:Child; D003042:Cocaine; D005128:Eye Diseases / Q000188:drug therapy; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use; D003932:Heroin; D006801:Humans; D007249:Inflammation / Q000382:microbiology; D007275:Injections, Intravenous; D008581:Meningitis / Q000382:microbiology; D010866:Natamycin / Q000627:therapeutic use; D012590:Sclera; D019966:Substance-Related Disorders / Q000150:complications*
chemical_list: D003932:Heroin; D000666:Amphotericin B; D010866:Natamycin; D005437:Flucytosine; D003042:Cocaine