Three-receptor, clonal expansion model for selection of self-recognition in the thymus.
The postulate is made that dual recognition by T lymphocytes is due to two types of receptor, one encoded by antibody genes and one by a distinct multigene family with simple rules for expression. This postulate leads to a model explaining ontogenic and evolutionary selection for self recognition, T lymphocyte effector function, the apparent high frequency of alloreactive T cells and immune response gene activity. The model is contrasted with previous explanations of self-recognition phenomena.
D000818:Animals; D001323:Autoantibodies; D001324:Autoantigens; D002454:Cell Differentiation; D002999:Clone Cells / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D007130:Immunoglobulin Idiotypes; D007519:Isoantigens; D008285:Major Histocompatibility Complex; D051379:Mice; D008954:Models, Biological; D011971:Receptors, Immunologic / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology*
D001323:Autoantibodies; D001324:Autoantigens; D007130:Immunoglobulin Idiotypes; D007519:Isoantigens; D011971:Receptors, Immunologic