Cytogenetic evidence for the localisation of the gene for congenital adrenal hyperplasia.
In the course of a study of the close linkage between the gene locus for the autosomal recessive disease, Congenital Adrenal Hyperplasia (CAH), and the major histocompatibility complex (MHC), a cytogenetic survey was undertaken. In one family, where a crossover might have occurred between some loci in the MHC complex and the locus for the 21-hydroxylase gene, there was also a crossover between the MHC locus and the centromere of chromosome 6.
D000312:Adrenal Hyperplasia, Congenital / Q000235:genetics*; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D003434:Crossing Over, Genetic; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D013255:Steroid 21-Hydroxylase / Q000235:genetics
D006680:HLA Antigens; D013255:Steroid 21-Hydroxylase