Inhibition of the immune response by Fc receptor-bound specific antibody on T lymphocytes.
Removal of naturally occurring membrane-bound antibody from the surface of nonadherent spleen cells by pronase enhances the in vitro plaque-forming cell response to sheep erythrocytes, and this enhancement can be abrogated by preincubation of the enzyme-treated cells in anti-sheep red blood cell antibody. This inhibitory effect is specific in that prior absorption with sheep erythrocytes but not with noncross-reacting red blood cells removes the activity from antibody-containing preparations. Whole IgG molecules are necessary to bind to Fc receptor; F(ab')2 fragments do not inhibit. The functionally significant Fc receptor-bound antibody in this system is found on the T lymphocyte.
D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000276:immunology; D001666:Binding Sites, Antibody; D004912:Erythrocytes / Q000276:immunology; D006462:Hemolytic Plaque Technique; D011402:Pronase / Q000494:pharmacology; D011961:Receptors, Fc / Q000276:immunology*; D012756:Sheep; D013154:Spleen / Q000276:immunology; D013552:Swine; D013601:T-Lymphocytes / Q000276:immunology*
D011961:Receptors, Fc; D011402:Pronase