title: Comparative distribution of Baker's antifolate (NSC 139105) in rat tissues after subcutaneous and intravenous injections.
abstract: The tissue distribution of BAF was compared by intravenous and subcutaneous injections in rats bearing Walker 256 carcinoma. Following a single dose (6 mg/kg containing 30 microCi 4,6-di-14C-BAF), the drug concentrations were determined by radiochemical and dihydrofolate reductase assays. The two methods gave comparable results. No metabolites were found by paper chromatographic separations.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D002279:Carcinoma 256, Walker / Q000032:analysis / Q000188:drug therapy*; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007422:Intestines / Q000032:analysis; D008099:Liver / Q000032:analysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014227:Triazines / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D014227:Triazines; C012071:triazinate