Avian lymphokines: 1. Thymic cell growth factor in supernatants of mitogen stimulated chicken spleen cells.
The present study provides first evidence for the presence of a thymic cell growth factor (TCGF) in supernatants (20 hrs) of mitogen (Con A) stimulated chicken spleen cells. 2 out of 3 batches of supernatant prepared according to a procedure originally described for the mouse system (10) induced a vigorous proliferative response of Con A prestimulated chicken spleen cells without significant mitogenic effect on unstimulated lymphocytes. No crossreactivity of this chicken-TCGF was observed with prestimulated murine lymphocytes, nor did potent mouse-TCGF preparations exhibit any proliferative effect on chicken cells. The implications of these data for both phylogenetic as well as practical experimental aspects are discussed.
D000818:Animals; D002645:Chickens / Q000276:immunology*; D003208:Concanavalin A / Q000494:pharmacology*; D003429:Cross Reactions; D005260:Female; D007376:Interleukin-2 / Q000096:biosynthesis / Q000494:pharmacology*; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000166:cytology / Q000276:immunology
D007376:Interleukin-2; D003208:Concanavalin A