Regulation of thymus-independent responses: unresponsiveness to a second challenge of TNP-Ficoll is mediated by hapten-specific antibodies.
CBA mice immunized with the TI-2 antigen TNP-Ficoll are unresponsive to a second challenge of the same antigen. In addition, spleen cells from unresponsive mice fail to respond to any dose of TNP-Ficoll in vitro. This hapten-specific unresponsive state is T cell independent and is due to hapten-specific IgM-mediated inhibition of B cell triggering. The mechanism of inhibition, although unknown, is unlikely to be antigen masking. In vitro responses to the TI-1 antigen TNP-LPS are not inhibited by concentrations of anti-TNP antibody, which completely suppress responses to TNP-Ficoll.
D000818:Animals; D000906:Antibodies; D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D005362:Ficoll / Q000276:immunology*; D006241:Haptens / Q000276:immunology; D007108:Immune Tolerance; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008819:Mice, Nude; D009578:Nitrobenzenes / Q000276:immunology*; D011134:Polysaccharides / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology*; D014301:Trinitrobenzenes / Q000276:immunology*
D000906:Antibodies; D006241:Haptens; D009578:Nitrobenzenes; D011134:Polysaccharides; D014301:Trinitrobenzenes; D005362:Ficoll