Studies on anti-inflammatory, analgesic and antipyretic activities of some indan acids.
A series of indan-1 acids were synthesized and screened for anti-inflammatory activity. All the reported compounds showed varying degrees of anti-inflammatory activity in carrageenin-induced paw oedema test. They also exhibited appreciable antipyretic and analgesic activity in various animal test models. Among these compounds 6-methoxy-indan-1-acetic acid (compound 11) and 5,6-dimethoxy-indan-1-acetic acid (compound 12) showed activity profile close to that of phenylbutazone having prolonged action and lower toxicity than the latter.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007189:Indans / Q000494:pharmacology* / Q000633:toxicity; D007192:Indenes / Q000494:pharmacology*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007189:Indans; D007192:Indenes