Histopathological findings in clinical gentamicin ototoxicity.
The temporal bone histopathological findings in a case of gentamicin sulfate-induced hearing loss and vertigo in an anephric patient undergoing hemodialysis are presented. A study of the sensory neuroepithelium of the cristae and maculae disclosed the presence of vacuoles with clubbing of the sensory cells. In the cochlea, loss of the innermost row of outer hair cells in the basal turn was the most prominent feature. These findings are discussed in light of reports of similar morphological changes in laboratory studies of gentamicin ototoxicity.
D007758:Ear, Inner / Q000187:drug effects / Q000473:pathology; D004432:Ear, Middle / Q000187:drug effects / Q000473:pathology; D005260:Female; D005839:Gentamicins / Q000009:adverse effects*; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced*; D006801:Humans; D008875:Middle Aged; D009392:Nephrectomy; D006435:Renal Dialysis; D013701:Temporal Bone / Q000187:drug effects / Q000473:pathology; D014722:Vestibule, Labyrinth / Q000187:drug effects
D005839:Gentamicins