title: Immune thrombocytopenia induced by cotrimoxazole.
abstract: Cotrimoxazole administration is occasionally associated with thrombocytopenia. Interference with folate metabolism has been postulated. The drug has also been postulated to induce an autoantibody by acting as a hapten, but proof has not been forthcoming. A case is reported in which the serum has been shown to contain an anti-platelet autoantibody requiring sulphamethoxazole or cotrimoxazole for activity.
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000139:chemically induced*; D001792:Blood Platelets / Q000276:immunology; D004338:Drug Combinations / Q000009:adverse effects; D005260:Female; D006801:Humans; D013420:Sulfamethoxazole / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000276:immunology; D014295:Trimethoprim / Q000009:adverse effects*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
chemical_list: D001323:Autoantibodies; D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole