Serum levels of alpha-1-antitrypsin in individuals with different Pi M subtypes.
Individuals with heterozygous Pi M subtypes were found to have higher serum levels of alpha 1-antitrypsin (alpha 1-AT) than homozygotes. The alpha 1-AT levels in heterozygotes showed a unimodal distribution. Among homozygotes, a tendency towards a bimodal distribution was found. The mechanism behind this difference is not known. The result can apparently not be explained as the result of a hitherto undiscovered deficiency gene.
D014644:Genetic Variation; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D000515:alpha 1-Antitrypsin / Q000235:genetics*
D000515:alpha 1-Antitrypsin