Carotid-cavernous sinus thrombosis caused by Aspergillus fumigatus. Case report.
A case is presented of Aspergillus fumigatus granuloma involving the sphenoid sinus, sella turcica, cavernous sinus, and the internal carotid artery. The diagnosis was established by a transsphenoidal biopsy. The infection proved difficult to treat and finally remitted after chemotherapy with a combination of amphotericin B, rifampin (rifampicin), and flucytosine (5-fluorocytosine). The spectrum of aspergillosis of the central nervous system is reviewed, and difficulties in treating this infection are considered.
D000328:Adult; D001228:Aspergillosis / Q000150:complications* / Q000175:diagnosis; D001232:Aspergillus fumigatus; D002341:Carotid Artery Thrombosis / Q000175:diagnosis / Q000209:etiology*; D002426:Cavernous Sinus; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis; D012851:Sinus Thrombosis, Intracranial / Q000175:diagnosis / Q000209:etiology*