[Changes in lymphoblastic transformation in preleukemic AKR/J mice].
The authors investigate the efficacy of the immune system along the AKR/J mouse life span. They employ the phytohemagglutinin (PHA)-induced lymphoblastic transformation test. The response is compared with the immune response obtained in BALB/C mice of the corresponding age. The blastic transformation was significatively lower at 15, 25 and 35 weeks in the AKR/J mouse than in the BALB/C mouse. At the age of 45 weeks the AKR/J mouse shows an increased proportion of lymphocytes in the thymus and spleen, a weight increase of these organs, and an augmented lymphoblastic transformation in response to PHA. This phenomena are not observed in the BALB/C mouse. When macrophages are removed from the lymphocytes preparation, the PHA-induced blastic transformation of lymphocytes is not produced at any age in either AKR/J or BALB/C mice strains.
D000375:Aging; D000818:Animals; D002478:Cells, Cultured; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D011289:Preleukemia / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism
Alteraciones en la transformación linfoblástica en ratones AKR/J preleucémicos.