title: Reward and detection thresholds for brain stimulation: dissociative effects of cocaine.
abstract: The effects of cocaine on both rewarding and detection thresholds for intracranial stimulation to the same brain sites in the same animals were determined. The drug caused a dissociation in effects on the two types of brain stimulation. Detection threshold was elevated at doses of cocaine that lowered the reward threshold.
mesh_terms: D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D008297:Male; D008474:Medial Forebrain Bundle / Q000187:drug effects; D009042:Motivation / Q000187:drug effects*; D051381:Rats; D012653:Self Stimulation / Q000187:drug effects*; D012684:Sensory Thresholds
chemical_list: D003042:Cocaine