Long-term suppression of central serotonergic activity by corticosteroids: a possible model of steroid-responsive myoclonic disorders.
Chronic administration of cortisol succinate (12.5 mg per kilogram per day) to guinea pigs suppressed jumping behavior induced by 1-5 hydroxytryptophan and abolished diurnal threshold variations of this behavior. Chronic corticosteroid administration did not alter threshold or diurnal variations of apomorphine-induced stereotypy. These observations suggest that the efficacy of corticosteroids in some human myoclonic movement disorders may be related to central serotonergic inhibition.
D006916:5-Hydroxytryptophan / Q000037:antagonists & inhibitors*; D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine; D002940:Circadian Rhythm / Q000187:drug effects; D006168:Guinea Pigs; D006801:Humans; D008954:Models, Biological; D009043:Motor Activity / Q000187:drug effects; D009207:Myoclonus / Q000139:chemically induced* / Q000188:drug therapy; D013239:Stereotyped Behavior / Q000187:drug effects*
D000305:Adrenal Cortex Hormones; D006916:5-Hydroxytryptophan; D001058:Apomorphine