[Correlation of the antiexudative, analgesic and antipyretic components in the action of nonsteroid anti-inflammatory preparations].
Experimental carragenin paw edema in rats, crams in rats induced by acetic acid, and yeast fever in rats were used to study antiexudative, analgetic and antipyretic action of 9 present-day non-steroidal anti-inflammatory drugs (acetylsalicylic acid, amidopyrin, analgin, phenylbutazone, mephenamic acid, voltaren, ibuprofen, indomethacin, naproxen). The correlation of individual types of anti-inflammatory activity was characterized in each drug. Of the drugs studied, the most pronounced anti-inflammatory action was exhibited by voltaren; indomethacin and naproxen were found to be less active. It was shown that the methods for the appraisal of the drugs activity make it possible to study not only their anti-inflammatory activity but also the effect on the inflammation mediators.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000188:drug therapy; D005122:Exudates and Transudates / Q000187:drug effects*; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D012216:Rheumatic Diseases / Q000188:drug therapy; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal
Sootnoshenie antiéksudativnogo, anal'geticheskogo i zharoponizhaiushchego komponentov v deĭstvii nesteroidnykh protivovospalitel'nykh preparatov.