Behavioral model for diffuse noxious inhibitory controls (DNIC): potentiation by 5-hydroxytryptophan.
The effects of the serotonin precursor 5-HTP, were determined in a behavioral DNIC paradigm (increase in vocalization threshold after intraperitoneal injection of the algogenic agent, phenylbenzoquinone). This counter-irritation phenomenon was strongly potentiated by 5-HTP, such potentiation being blocked by the 5-HT receptor blocker, cinanserin. These results are in keeping with those of our recent single unit work in dorsal horn convergent neurons.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000818:Animals; D016227:Benzoquinones; D002928:Cinanserin / Q000494:pharmacology*; D002934:Cinnamates / Q000494:pharmacology*; D004357:Drug Synergism; D004558:Electric Stimulation; D008297:Male; D008960:Models, Psychological; D010146:Pain / Q000503:physiopathology; D011809:Quinones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012684:Sensory Thresholds / Q000187:drug effects; D014828:Vocalization, Animal / Q000187:drug effects*
D016227:Benzoquinones; D002934:Cinnamates; D011809:Quinones; C029322:phenylbenzoquinone; D006916:5-Hydroxytryptophan; D002928:Cinanserin