[Functional activity of T- and B-lymphocyte populations after rubomycin and carminomycin exposure].
The dynamics of antibody genesis at various periods after single administrations of the antibiotics to mice and the mice spleen capacity to cooperate with intact T- and B- lymphocytes and macrophages in an immune response to sheep red cells were studied. It was found that rubomycin in equal with carminomycin doses by the toxicity induced more significant and slower reducing shifts in the immune response. Analysis of the cell mechanism of the immunosuppressive effects of rubomycin and carminomycin at early periods after their administration showed that the antibiotics inhibited mainly the functional activity of B-lymphocytes and had not effect on the helper function of T-lymphocytes. The immunological activity of macrophages was inhibited insignificantly.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D002360:Carubicin / Q000276:immunology*; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012756:Sheep; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
D002360:Carubicin; D003630:Daunorubicin
Funktsional'naia aktivnost' populiatsiĭ T- i B-limfotsitov posle vozdeĭstviia rubomitsina i karminomitsina.