Functional alterations in non-T cells in rheumatic heart disease.
The mediation of the T cell lymphoproliferative response to streptococcal blastogen A by non-T mononuclear cells was studied in patients with rheumatic heart disease (RHD) and control subjects. Non-T cells are essential for T cell response to blastogen A. Non-T cells from RHD patients were less effective in enabling the T lymphocyte response to blastogen A than control non-T cells though no consistent difference was observed in the response to phytohaemagglutinin. The results suggest that a functional alteration is present in the non-T cells from RHD patients which might be related to the pathogenesis of the disease.
D001426:Bacterial Proteins; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008934:Mitogens / Q000276:immunology; D014066:Palatine Tonsil / Q000276:immunology; D012214:Rheumatic Heart Disease / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology
D001426:Bacterial Proteins; D008934:Mitogens; C034866:streptococcal group A mitogen