Defective phagocytosis confined to Staphylococcus aureus in a female infant with recurrent infections.
Defective chemotaxis and phagocytosis of Staphylococcus aureus was identified in a female infant with marked hepatosplenomegaly and recurrent infections. Neutrophil mobilization from the marrow and marginal pool; random mobility; phagocytosis of yeast particles, latex beads and carbon particles; phagocytosis and intracellular killing capacity of Streptococcus pyogenes and E. coli; and NBT dye reduction were normal. Infiltration of neutrophils was depressed in the skin window test. The complement system and cellular immunity were intact. The patient also had a persistent EB virus infection. Defective phagocytosis limited to Staphylococcus aureus seems to be caused by an intrinsic cellular defect, such as congenital defect in neutrophil receptors for Staphylococcus aureus.
D001424:Bacterial Infections / Q000150:complications; D002633:Chemotaxis; D005260:Female; D006529:Hepatomegaly / Q000150:complications; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis*; D007223:Infant; D009504:Neutrophils; D010587:Phagocytosis; D012884:Skin Window Technique; D013163:Splenomegaly / Q000150:complications; D013211:Staphylococcus aureus