Cell death (apoptosis) in the mouse small intestine after low doses: effects of dose-rate, 14.7 MeV neutrons, and 600 MeV (maximum energy) neutrons.
The production of dead (apoptotic) cells by low doses of gamma-rays was independent of dose-rate between 0.27 and 450 cGy per min. The r.b.e. for doses of 14.7 MeV neutrons between 1 and 15 cGy was about 4, and for neutrons generated by bombarding a beryllium target with 600 MeV protons the r.b.e. was about 2.7. The dose-incidence curves for all three radiation types reached a plateau at about 3-4 dead cells per crypt section, and this occurred at about 20-40 cGy of gamma-rays. These curves are compatible with exponential survival of the cell population at risk (D0 of 24 cGy for gamma-rays, 6 cGy for 14.7 MeV neutrons and 9 cGy for 600 MeV neutrons). Since the dose-response is exponential there is no indication of much higher r.b.e. values at very low doses, a point of concern in radiation protection. The spatial distribution of dead cells in the crypt was similar after doses of gamma-rays or neutrons, indicating that the same population of target cells was affected in both cases.
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D002588:Cesium Radioisotopes; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D007421:Intestine, Small / Q000528:radiation effects*; D008297:Male; D051379:Mice; D009502:Neutrons; D012062:Relative Biological Effectiveness; D013997:Time Factors
D002588:Cesium Radioisotopes; D003037:Cobalt Radioisotopes