title: Urinary oligosaccharides inhibit adhesion of E. coli onto canine urinary tract epithelium.
abstract: Canine urine fractions were tested for their capacity to release Escherichia coli from everted canine ureteral segments. Urine was effective in detaching epithelially-bound E. coli; the active principle was a small molecular weight carbohydrate. Treatment with lectins decreased the degree of E. coli surface colonization, which confirms the importance of the mucosal glycocalyx in adhesion. The adhesion-inhibition by the active components may be by competition, which implies that the bacteria-releasing sugars resemble the determinant sugar moieties on the epithelial glycocalyx.
mesh_terms: D000268:Adhesiveness; D000818:Animals; D002850:Chromatography, Gel; D004285:Dogs; D004848:Epithelium / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects*; D037102:Lectins / Q000494:pharmacology; D009844:Oligosaccharides / Q000494:pharmacology / Q000652:urine*; D014513:Ureter / Q000382:microbiology*
chemical_list: D037102:Lectins; D009844:Oligosaccharides