Presence of receptors for IgD on human T and non-T lymphocytes.
Ig-coated latex particles were used to study the presence in human blood of lymphocytes with receptors for various Ig classes. A significant proportion of cells bound to particles coated with IgG, IgA and IgM. In addition, 0--6.5% (mean 2.2%) peripheral blood lymphocytes from normal blood donors were able to form rosettes with IgD-coated latex particles. Inhibition studies showed that the latter receptors were distinct from those directed against IgG, IgA and IgM. IgD receptor-bearing cells seemed to exist both among T cells and non-T cells but were 3--10 times more frequent in the non-T-cell population.
D001666:Binding Sites, Antibody; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007072:Immunoglobulin D / Q000032:analysis / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D007840:Latex / Q000276:immunology; D008863:Microspheres; D009000:Monocytes / Q000276:immunology; D011971:Receptors, Immunologic; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D007070:Immunoglobulin A; D007072:Immunoglobulin D; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007840:Latex; D011971:Receptors, Immunologic