Lymphocyte subpopulations in man: characterization of in vivo-educated, alloreactive, cytotoxic lymphocytes.
Alloreactive cytotoxic lymphocytes present in peripheral blood of two normal humans have been studied by rosette fractionation experiments. It is shown that the effector cells, have receptors for SRBC, low avidity FcR, are nylon non-adherent and without CR. These results reveal a phenotype of membrane markers which is very much like the phenotypes of the major part of K cells, NK cells and the effector cells in mitogen induced cell-mediated cytotoxicity, indicating a common ancestor in the immune system. From a functional point of view all these cytotoxic effector cells may be T cells, some specific others non specific, in parallel to T helper and suppressor lymphocytes.
D000328:Adult; D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic; D005260:Female; D005374:Filtration / Q000379:methods; D006801:Humans; D007518:Isoantibodies / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D010641:Phenotype; D011961:Receptors, Fc / Q000276:immunology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*; D014357:Trypsin / Q000494:pharmacology
D007518:Isoantibodies; D011961:Receptors, Fc; D014357:Trypsin