Studies on immunosuppressive and anti-inflammatory effect of adriamycin.
The analysis of immunosuppressive and anti-inflammatory effect of adriamycin in vivo was carried out. Adriamycin restrains blast reaction and decreases the building in of H3 thymidine to the nucleus of lymphocytes. At the same time it decreases the number of B lymphocytes in peripheral blood but it does not influence the level of T lymphocytes. Adriamycin restrains also nonspecific inflammatory reactions reducing the intensity of inflammatory reactions induced by xylene and carrageenin. It also reduces the inflammatory process of granulation. It does not affect histamine and prostaglandin receptors. After discussing the results it was noted that cytostatic effect of adriamycin is accompanied by immunosuppressive and inflammatory components.
D000373:Agglutinins / Q000096:biosynthesis; D000799:Angioedema / Q000139:chemically induced / Q000188:drug therapy; D000818:Animals; D000893:Anti-Inflammatory Agents; D001402:B-Lymphocytes / Q000276:immunology; D002351:Carrageenan / Q000009:adverse effects; D004137:Dinitrochlorobenzene / Q000009:adverse effects; D004317:Doxorubicin / Q000276:immunology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D006168:Guinea Pigs; D007166:Immunosuppressive Agents; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology; D014992:Xylenes / Q000009:adverse effects
D000373:Agglutinins; D000893:Anti-Inflammatory Agents; D004137:Dinitrochlorobenzene; D007166:Immunosuppressive Agents; D014992:Xylenes; D004317:Doxorubicin; D002351:Carrageenan