Subacute sclerosing panencephalitis: clinical and immunologic study of 23 patients.
Lymphocyte subpopulations ("active' T cells, total T cells, and B cells), leukocyte migration, lymphocyte transformation, complements (CH50, C3, and C4), and immune complexes in serum and cerebrospinal fluid were studied in 23 patients with subacute sclerosing panencephalitis. The percentage of active T cells was normal. The number of patients with positive migration inhibitory response to phytoyhemagglutinin was lower than controls, corresponding to the diminished percentage of total T cells in patients. C1q binding (immune complex formation) was found in the sera of 10 patients.
D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis; D000936:Antigen-Antibody Complex; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000032:analysis; D008297:Male; D013344:Subacute Sclerosing Panencephalitis / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000032:analysis
D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex