PGF2 alpha stimulates release of PGE2 and PGI2 in the isolated perfused rat heart.
The effect of prostaglandin F2 alpha on the release of PGI2 and PGE2 was investigated in isolated perfused rat heart. PGF2 alpha at concentrations of 1.7 nmoles liter-1 or higher increased the release of PGI2 and PGE2 alpha. The release of PGI2 was highest after 3 to 4 min of perfusion with PGF2 alpha. This phenomenon may be of physiological significance and might explain the observed variable effects of PGF2 alpha on vascular resistance.
D000818:Animals; D003331:Coronary Vessels / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000378:metabolism*; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D010477:Perfusion; D011453:Prostaglandins / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism*; D011460:Prostaglandins F / Q000494:pharmacology*; D051381:Rats; D014655:Vascular Resistance / Q000187:drug effects
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D011464:Epoprostenol