Several new monoclonal antibodies directed to human T-cell leukemia antigens.
Murine monoclonal hybridoma antibodies were generated efficiently by using a human leukemia antigen preparation which was isolated from the cell membranes of MOLT-4 (a T-leukemia cell line) by means of a novel system. The generated monoclonal hybridoma antibodies were screened and characterized by a radioimmunoassay using a variety of cell specimens as targets. The results showed that the antigen(s) defined by several of these monoclonal hybridoma antibodies is associated with human T-cell leukemia and further suggest that this antigen(s) is a new type of human leukemia-associated cell surface antigen.
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D002460:Cell Line; D006801:Humans; D006825:Hybridomas / Q000276:immunology; D007938:Leukemia / Q000276:immunology; D008223:Lymphoma / Q000276:immunology; D008562:Membrane Glycoproteins; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D008562:Membrane Glycoproteins; C028388:thymus-leukemia antigens