title: Low constitutive activity of aryl hydrocarbon hydroxylase in phytohaemoagglutinin-stimulated peripheral blood mononuclear cells of children after treatment for acute lymphoblastic leukemia.
abstract: In six children in the first remission after treatment of acute lymphoblastic leukemia (ALL) the constitutive activity of aryl hydrocarbon (benzo-[alpha]pyrene) hydroxylase (AHH) (0.14 +/- 0.04 U, i.e. pmol of 3-OH-benzo[alpha] pyrene x 10(-6) cells x min-1) in phytohaemoagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC) was significantly lower (P 0.05) than the constitutive activities in the parents of the children (0.25 +/- 0.09 U) and in the control adult group (0.26 +/- 0.09 U). In methylcholanthrene (MC)-induced activities of AHH no significant differences were observed between the above groups.
mesh_terms: D000328:Adult; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D002478:Cells, Cultured; D002675:Child, Preschool; D006801:Humans; D007945:Leukemia, Lymphoid / Q000378:metabolism* / Q000628:therapy; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000201:enzymology* / Q000378:metabolism; D008748:Methylcholanthrene / Q000494:pharmacology; D010835:Phytohemagglutinins / Q000494:pharmacology
chemical_list: D010835:Phytohemagglutinins; D008748:Methylcholanthrene; D001189:Aryl Hydrocarbon Hydroxylases