Alpha 1-antitrypsin and acute anterior uveitis.
To test the pathogenetic role of the phenotype MZ of alpha 1-antitrypsin/alpha 1-protease inhibitor (PI) in acute anterior uveitis (AAU), 156 patients with AAU were examined. Sera of all patients and 120 healthy controls were PI-typed using isoelectric focusing. There were no significant differences in PI MZ frequencies either between the patients with AAU (4.5%) and the controls (4.2%), or between AAU patients with associated rheumatic diseases (4.8%) and AAU patients with no associated disease (4.3%). The results indicate that the PI MZ type is not closely associated with AAU among Finns.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005387:Finland; D005787:Gene Frequency; D006801:Humans; D007525:Isoelectric Focusing; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011480:Protease Inhibitors / Q000378:metabolism; D014605:Uveitis / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000235:genetics / Q000378:metabolism*
D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin