High-performance liquid chromatographic assay for benzocaine and p-aminobenzoic acid including preliminary stability data.
A high-performance liquid chromatographic assay was developed that separates and quantitates benzocaine and its primary degradation product, p-aminobenzoic acid. This method is rapid, sensitive, and specific. Preliminary stability data obtained with this method demonstrate its utility for this purpose.
D010129:4-Aminobenzoic Acid / Q000032:analysis*; D062365:Aminobenzoates / Q000032:analysis*; D001566:Benzocaine / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D010710:Phosphates; D013696:Temperature; D013997:Time Factors
D062365:Aminobenzoates; D010710:Phosphates; D010129:4-Aminobenzoic Acid; D001566:Benzocaine