Chronic lymphocytic leukemia: a monoclonal disease.
A black woman with chronic lymphocytic leukemia (CLL) was found to have monoclonal B lymphocytes with one type of surface immunoglobulin and one variant of G6PD (glucose-6-phosphate dehydrogenase) (G6PD A). Erythrocytes and T cells contained both G6PD A and G6PD B and hence were of polyclonal origin. The CLL cells in this patient likely arose from a developmental stage later than the step of differentiation into T and B lymphocytes. Furthermore, her erythrocytes did not arise from a stem cell affected by the CLL process.
D000368:Aged; D001402:B-Lymphocytes / Q000201:enzymology / Q000276:immunology; D002999:Clone Cells / Q000201:enzymology / Q000276:immunology; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D007945:Leukemia, Lymphoid / Q000097:blood* / Q000201:enzymology / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology
D007527:Isoenzymes; D011947:Receptors, Antigen, B-Cell; D005954:Glucosephosphate Dehydrogenase