Influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas.
Previous studies have shown that in certain tissues, including colonic carcinomas, cell proliferation may be promoted by serotonin, and indirect evidence suggests that the effects of this amine on colonic tumours involves a cellular-uptake mechanism. In the present study, two specific inhibitors of serotonin uptake, Citalopram and Fluoxetine, are examined for their effects on cell proliferation and tumour growth. Each of the agents was found to suppress cell division in dimethylhydrazine-induced colonic tumours in rats, and to retard the growth of 2 out of 3 lines of human colonic tumours propagated as xenografts in immune-deprived mice.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D015283:Citalopram; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000473:pathology*; D004848:Epithelium / Q000187:drug effects; D005473:Fluoxetine / Q000494:pharmacology; D007422:Intestines / Q000187:drug effects*; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012004:Rectal Neoplasms / Q000139:chemically induced / Q000473:pathology*; D012702:Serotonin Antagonists / Q000494:pharmacology*
D011437:Propylamines; D012702:Serotonin Antagonists; D005473:Fluoxetine; D015283:Citalopram