Effects of early larval thymectomy on mitogen responses in leopard frog (Rana pipiens) tadpoles.
Two to 3-month old tadpoles (Rana pipiens), thymectomized 2-3 weeks postfertilization, exhibited: sharply reduced numbers of splenic and blood lymphocytes; no in vitro lymphocyte responsiveness to PHA; and normal in vitro lymphocyte reactivity to LPS. These results reveal lymphocyte heterogeneity in this anuran species.
D000818:Animals; D005260:Female; D007111:Immunity, Cellular; D007814:Larva / Q000276:immunology; D007958:Leukocyte Count; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation; D008214:Lymphocytes; D008297:Male; D008934:Mitogens / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D011894:Rana pipiens / Q000276:immunology*; D013934:Thymectomy
D008070:Lipopolysaccharides; D008934:Mitogens; D010835:Phytohemagglutinins