Positive direct antiglobulin test in normal individuals.
65 normal, healthy people with a positive direct antiglobulin test (DAT) have been identified in a population of blood donors over a period of 14 years. 32 of them have been recalled for detailed study. A strong positive correlation with increasing age was noted, comparable to that seen in hospital patients with a positive DAT. No feature known to cause a positive DAT was identified in the healthy individuals, only 1 of whom went on to develop autoimmune haemolytic anaemia.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology*; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D001782:Blood Donors; D003298:Coombs Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013223:Statistics as Topic
D000888:Antibodies, Anti-Idiotypic