title: The structure of the lens proteins.
abstract: Although lens structural proteins are extremely diverse, there appear to be common structural motifs or folding units from which the beta-gamma-crystallins can be constructed. X-ray diffraction techniques have solved the atomic three-dimensional structure of monomeric bovine gamma-II. The related protein, beta Bp, the principal subunit of bovine beta-crystallin has been predicted, using computer graphics techniques, to have a similar tertiary structure. These molecular models show the spatial orientation of some of the reactive side-chains which have been implicated in oxidative disruption of lens structure.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D003459:Crystallins; D008958:Models, Molecular; D011487:Protein Conformation
chemical_list: D003459:Crystallins