Myasthenia gravis with a monoclonal gammopathy--report of a case.
An elderly man with relapsing myasthenia gravis was found to have hypergammaglobulinaemia, a monoclonal peak of gamma mobility and paraproteinaemia IgG, type K. Bence-Jones proteinuria, type K was present. This is the fourth report of myasthenia gravis associated with a monoclonal gammopathy. Myasthenia gravis is considered to be an autoimmune disease. Recent findings implicate a dysfunction of cellular immunity in the pathogenesis of both immunoproliferative and autoimmune disease. We suggest that the association of myasthenia gravis and monoclonal gammopathy in our patient might have stemmed from a disorder of T lymphocyte function.
D000368:Aged; D001536:Bence Jones Protein / Q000032:analysis; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology*; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D009157:Myasthenia Gravis / Q000276:immunology*; D010265:Paraproteinemias / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D007074:Immunoglobulin G; D001536:Bence Jones Protein