title: [Mixed connective tissue disease (Sharp syndrome)].
abstract: In the Sharp syndrome we have to do with a mixed collagenosis with symptoms of sclerodermia, erythematodes visceralis, dermatomyositis and rheumatoid arthritis. Above all are observed a Raynaud syndrome, polyarthritis and polyarthralgias, swellings of hands and fingers and myositis and myalgia, respectively. For the ascertainment of the diagnosis as independent picture of a disease the immunological profile is decisive. On the basis of three casuistic cases the author adopts a definite attitude to the Sharp syndrome as independent immunopathy. Questions of diagnostics, therapy and prognosis are discussed.
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000175:diagnosis* / Q000276:immunology; D011379:Prognosis
chemical_list: D000974:Antibodies, Antinuclear
vernacular_title: Mixed connective tissue disease (Sharp-Syndrom).