Termination of pregnancy by intramuscular administration of 15 (S)-15-methyl-prostaglandin in F2 alpha.
The use of 15 (S)-15-methyl-prostaglandin F2 alpha for second-trimester termination of pregnancy, induction of labor in the presence of a dead or severely malformed fetus, and the management of molar pregnancy was investigated in 212 women. The dosage regime was 250 microgram of the prostaglandin analogue every 1 to 3 hours. Cumulative expulsion rates amounted to 94 and 97% after 24 to 36 hours, respectively. Gastrointestinal side effects occurred in 48% of the patients, and both the number and intensity of the episodes were significantly reduced by antiemetic and antidiarrheal drugs. No serious complications occurred.
D000028:Abortion, Induced; D000293:Adolescent; D000328:Adult; D002260:Carboprost / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology; D006801:Humans; D007748:Labor Stage, Second / Q000187:drug effects; D008875:Middle Aged; D006473:Postpartum Hemorrhage / Q000209:etiology; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D013997:Time Factors
D011461:Prostaglandins F, Synthetic; D002260:Carboprost