Lymphocyte subpopulations in human lymph nodes: a normal range.
Detailed surface marker studies were performed on 21 nodes from control subjects, 12 normal and 9 showing reactive hyperplasia. Reactive nodes showed a significantly decreased proporation of T lymphocytes (median 44%) and increased proportion of B lymphocytes (median 32%) when compared with normal nodes (median 68% and 18%, respectively). The increase in B lymphocytes was seen in all immunoglobulin classes studied. The values for normal nodes were comparable with three previous studies of nodes confirmed to be normal by histology. On the other hand, the results from reactive nodes were similar to the majority of previously published "control" nodes, many of which were histologically abnormal. The importance of ensuring that control nodes are histologically normal is emphasized by this study.
D001402:B-Lymphocytes; D006801:Humans; D006965:Hyperplasia; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000166:cytology* / Q000473:pathology; D008214:Lymphocytes; D012016:Reference Values; D013601:T-Lymphocytes