T lymphoreceptopathy in systemic lupus erythematosus.
Decreases in numbers and functions of SLE T lymphocytes as a form of lymphoreceptopathy were investigated using T lymphocytes and sera obtained from both SLE patients and healthy subjects with respect to the effects of suppressor T cells and Con A induced suppressor factor against antibody formation, changes in the membrane microviscosity and the ultrastructure of membrane associated particles (MAPs) of T lymphocytes. The lymphoreceptopathy of SLE T lymphocytes was induced by decreased microviscosity and abnormalities of distribution, size and density of MAPs on the T lymphocyte membrane which can be modulated by serum factors consisting mainly of IgG as T cell membrane binding antibody and partially of IgM as cytotoxic antibody.
D000917:Antibody Formation; D003208:Concanavalin A / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000302:isolation & purification; D007165:Immunosuppression Therapy; D007958:Leukocyte Count; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000302:isolation & purification; D013601:T-Lymphocytes / Q000276:immunology* / Q000648:ultrastructure; D014783:Viscosity
D007074:Immunoglobulin G; D011947:Receptors, Antigen, B-Cell; D003208:Concanavalin A