Changes of corticosteroid spectrum in urine in members of crew of spaceship "Soyuz-22".
The urinary excretion of 17-hydroxycorticosteroids and the relations between the glucocorticoids in urine and their precursors as well as between 17-hydroxycorticoids and 17-hydroxycorticoids and 17-dehydroxycorticosteroids was measured in two subjects before and after 8 days flight in spaceship "Soyuz-22". During a readaptation period after the space flight activation of the glucocorticoid function of adrenals was observed which was accompanied by signs of stress and relative deficiency of 11-hydroxylation in glucocorticoid synthesis. The assumptions on possible causes of observed changes are discussed.
D000305:Adrenal Cortex Hormones / Q000652:urine*; D000337:Aerospace Medicine; D003345:Corticosterone / Q000031:analogs & derivatives / Q000652:urine; D003348:Cortisone / Q000652:urine; D003350:Cortodoxone / Q000031:analogs & derivatives / Q000652:urine; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D008297:Male; D013026:Space Flight; D013760:Tetrahydrocortisol / Q000652:urine; D013761:Tetrahydrocortisone / Q000652:urine
D000305:Adrenal Cortex Hormones; D013761:Tetrahydrocortisone; C003676:tetrahydrocorticosterone; C009412:tetrahydro-11-deoxycortisol; D013760:Tetrahydrocortisol; C003552:11-dehydrocorticosterone; D003348:Cortisone; D003345:Corticosterone; D003350:Cortodoxone; D006854:Hydrocortisone