[Effect of hydroxyprogesterone caproate on immunological skin tests and on the T-lymphocytes in cancer of the corpus uteri].
Under study was the effect of oxyprogesterone-capronate (500 mg daily, total dosage of 10 g) on delayed cutaneous hypersensitivity reaction (DCHR) to tuberculin and candidine as well as the level of T-lymphocytes and cortisol in the peripheral blood in 34 patients with primary cancer of the corpus uteri. Prior to the treatment there was a considerable negative correlation between metabolic and immunological indices. Under OPC exposure DCHR enhanced in 62% of observations. In 7 of 12 patients the level of T-lymphocytes was increased and blood cortiol level decreased in 6 of 11 patients. 58 per cent of the observations showed a parallelism between the effect of OPC on the skin tests and the tumor histostructure, and in 8 of 12 patients on the level of T-lymphocytes and the tumor histostructure.
D000368:Aged; D000900:Anti-Bacterial Agents; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006908:Hydroxyprogesterones / Q000276:immunology*; D018942:Macrolides; D008875:Middle Aged; D011090:Polyenes; D012882:Skin Tests; D013601:T-Lymphocytes / Q000187:drug effects*; D014374:Tuberculin Test; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000276:immunology*
D000900:Anti-Bacterial Agents; D006908:Hydroxyprogesterones; D018942:Macrolides; D011090:Polyenes; C010428:candidin; D006854:Hydrocortisone
Vliianie oksiprogesteron-kapronata na kozhnye immunologicheskie testy i T-limfotsity u bol'nykh rakom tela matki.