Chromogenic peptide substrate assays in patients with multiple trauma.
Daily monitoring of the plasma proteolytic enzyme systems i.e. the coagulation, the fibrinolytic and the kallikrein-kinin system in multitraumatized patients with chromogenic substrate assays disclosed significant differences in the levels of Prekallikrein, Hageman Factor, Antithrombin-III, Prothrombin in survivors (N = 9) and fatal cases (N = 6) during the first week after admission. Since chromogenic peptide substrate assays are simple, cheap and easily automated, close monitoring of critical care patients may be rewarding.
D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000032:analysis; D001779:Blood Coagulation Factors / Q000032:analysis; D002863:Chromogenic Compounds; D005174:Factor XII / Q000032:analysis; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D007610:Kallikreins / Q000097:blood*; D007705:Kinins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011288:Prekallikrein / Q000032:analysis; D011516:Prothrombin / Q000032:analysis; D014947:Wounds and Injuries / Q000201:enzymology*
D001779:Blood Coagulation Factors; D002863:Chromogenic Compounds; D007705:Kinins; D000990:Antithrombin III; D011516:Prothrombin; D005174:Factor XII; D011288:Prekallikrein; D007610:Kallikreins