Positron imaging feasibility studies: selective tumor concentration of 3H-thymidine, 3H-uridine, and 14C-2-deoxyglucose.
The potential usefulness of substrates for glycolysis and nucleic acid synthesis as tumor imaging agents was compared to that of 67Ga-citrate. In separate experiments, 3H-thymidine, 3H-uridine, 14C-2-deoxyglucose, and 67Ga-citrate were injected intraveneously into BALB/c mice with solid subcutaneous EMT-6 sarcomas. For the 3H- and 14C-labeled substrates, absolute uptakes in tumor and tumor-to-blood ratios were as high 1 hour after injection as the comparable maximum values achieved for 67Ga-citrate after 48 hours. These studies suggest that positron-labeled analogues of thymidine, uridine, and 2-deoxyglucose should be useful radiopharmaceuticals for tumor imaging by positron-emission tomography.
D000818:Animals; D002250:Carbon Radioisotopes / Q000378:metabolism; D003847:Deoxyglucose / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D014055:Tomography, Emission-Computed / Q000379:methods*; D014316:Tritium / Q000378:metabolism; D014529:Uridine / Q000378:metabolism
D002250:Carbon Radioisotopes; D014316:Tritium; D003847:Deoxyglucose; D013936:Thymidine; D014529:Uridine