[Antiphlogistic and analgesic activity of 3-carboxymethylthio-5-aryl-4-methyl- and 4-phenyl-4H-1,2,4-triazoles].
The antiinflammatory, analgesic and antiproteolytic activity was studied for some 3-carboxymethylthio-4H-1,2,4-triazole derivatives in order to discover the influence of substituents in positions 4- and 5- in the 3-mercapto-4H-1,2,4-triazole nucleus and the possibility of correlating antiinflammatory and antiproteolytic activity.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D051379:Mice; D051381:Rats; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014230:Triazoles
Attività antiflogistica e analgesica di 3-carbossimetiltio-5-aril-4-metil e 4-fenil-4H-1,2,4-triazoli.