Circulating immune complexes in eosinophilic fasciitis.
Serum immune complexes were measured in 22 patients with eosinophilic fasciitis, 8 of whom had serial determinations. Elevated levels were found by Raji cell radioimmunoassay in 14 (64%) patients, by agarose gel electrophoresis in 13 (59%), and by C1q agglutination-inhibition in 9 (41%). Elevated levels by Raji cell assay were present more frequently at times of active disease [17 of 22 sera (77%)] than at times of inactive disease [2 of 24 (8%) (P less than 0.0005)] and were more closely correlated with disease activity than were eosinophilia, hypergammaglobulinemia, or increased erythrocyte sedimentation rate.
D000328:Adult; D000368:Aged; D000372:Agglutination Tests; D000936:Antigen-Antibody Complex / Q000032:analysis*; D001799:Blood Sedimentation; D003166:Complement Activating Enzymes; D015922:Complement C1q; D004587:Electrophoresis, Agar Gel; D004802:Eosinophilia / Q000276:immunology*; D005208:Fasciitis / Q000276:immunology*; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D000936:Antigen-Antibody Complex; D015922:Complement C1q; D003166:Complement Activating Enzymes