A high level of colony-stimulating activity in a lung cancer patient with extensive leucocytosis, and the establishment of a CSA producing cell line (KONT).
Colony-stimulating activity (CSA) was demonstrated in materials taken from a patient suffering from lung cancer associated with excessive leucocytosis. CSA was detected not only in his urine, serum and pleural effusion but also in the supernatant of cell cultures originating from the effusion. The excessive leukocytosis of the patient might be due to a CSA producing tumor. A cell line (KONT) originating from the CSA producing tumor has been maintained for 4 years and shown to produce mouse- and human-CSA.
D000328:Adult; D000818:Animals; D001853:Bone Marrow / Q000032:analysis; D002460:Cell Line; D003115:Colony-Stimulating Factors / Q000096:biosynthesis* / Q000097:blood / Q000652:urine; D003470:Culture Media; D005870:Giant Cell Tumors / Q000097:blood* / Q000150:complications; D006801:Humans; D007964:Leukocytosis / Q000097:blood* / Q000150:complications; D008175:Lung Neoplasms / Q000097:blood* / Q000150:complications; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008819:Mice, Nude; D010996:Pleural Effusion / Q000032:analysis / Q000166:cytology / Q000378:metabolism
D003115:Colony-Stimulating Factors; D003470:Culture Media