[Ultrastructure and interaction of normal killer cells from human blood and target cells sensitive to them].
Morphological properties of cells possessing a natural cytotoxic activity obtained from blood of healthy persons have been studied, as well as the process of their interaction with sensitive target-cells (K-562). By means of electron microscopy, during incubation at 37 degrees C, appearance of specific morphological manifestations of cytolytic action of the effector-cells forming rather tight contacts with the target-cells (vacuolization of cytoplasm, ring-form defects in plasmalemma, subsequent destruction of the target-cells) has been followed. Morphological features of cytotoxic leucocytes are similar to the morphological criteria specific for T gamma (T-lymphocytes possessing receptors for Fc-fragment of immunoglobulin G) and zero lymphocytes: a rather low nuclear-cytoplasmic ratio, a well developed Golgi complex, a rather great amount of mitochondria.
D002450:Cell Communication; D002460:Cell Line; D002470:Cell Survival; D002478:Cells, Cultured; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology / Q000648:ultrastructure*; D004915:Leukemia, Erythroblastic, Acute; D008297:Male; D008854:Microscopy, Electron; D009000:Monocytes / Q000166:cytology / Q000648:ultrastructure
Ul'trastruktura i vzaimodeĭstvie normal'nykh killerov iz krovi cheloveka i chuvstvitel'nykh k nim kletok-mishenei.