title: The short effect of pelvic radiotherapy of gynecological cancers on humoral and cell mediated immunity.
abstract: An analysis of short effect of pelvic irradiation on cellular and humoral immunity was made in 24 patients treated by irradiation alone or a combination of surgery and irradiation for uterine carcinoma, at 2, 6, 12 months after loco-regional therapy. Twelve months later there is a decrease of T lymphocytes (P = 0.01), whereas the B lymphocytes count is normal; the percentage of T and B lymphocytes remains stable, but the lymphocyte response to PHA after 3 days is reduced (p = 0.03). A significant decrease of immunoglobulins G, A and M is observed.
mesh_terms: D000328:Adult; D000368:Aged; D000917:Antibody Formation / Q000528:radiation effects; D001402:B-Lymphocytes / Q000528:radiation effects; D005260:Female; D005833:Genital Neoplasms, Female / Q000276:immunology / Q000532:radiotherapy*; D006801:Humans; D007111:Immunity, Cellular / Q000528:radiation effects; D008875:Middle Aged; D010388:Pelvis; D013601:T-Lymphocytes / Q000528:radiation effects; D013997:Time Factors