title: Lymphocyte subpopulations in neonates, young children and adults as detected by six cell surface markers.
abstract: In this study, six surface marker tests were performed on lymphocytes from normal individuals of three age groups: neonates, children from 0 to 2 years of age, and adults. Determined were the proportions of T cells binding sheep red blood cells, of B cells carrying surface immunoglobulins or binding mouse red blood cells, and of lymphocytes bearing receptors for IgM, for IgG or for complement. The T cell percentage appeared to increase with the age; the percentage of B cells was highest in the children's group, as determined by both marker tests. Neonates had a much lower proportion of IgM-receptor bearing cells than older individuals. The variation in the percentages of T cells and of IgM-receptor bearing cells in the young age groups was relatively large as compared to adults. The significance of these observations is discussed; they may be of value for the proper evaluation of results obtained in diagnostical tests on neonates and young children.
mesh_terms: D000328:Adult; D000367:Age Factors; D001402:B-Lymphocytes / Q000276:immunology; D002675:Child, Preschool; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007231:Infant, Newborn; D008214:Lymphocytes / Q000145:classification* / Q000276:immunology*; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D011947:Receptors, Antigen, B-Cell; D011951:Receptors, Complement; D011961:Receptors, Fc; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011947:Receptors, Antigen, B-Cell; D011951:Receptors, Complement; D011961:Receptors, Fc