Phenotypic diversity of T cell leukemias.
A series of monoclonal antibodies and additional selective markers (e.g. TdT) have been used to describe the detailed composite phenotypes expressed by cells in 172 cases of T cell leukemia. The results provide further evidence for a striking correlation between phenotype, maturation arrest, and clinical subgroup, and have important implications for our understanding of the origins of T cell malignancy.
D000328:Adult; D000368:Aged; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D002471:Cell Transformation, Neoplastic / Q000276:immunology; D006801:Humans; D007938:Leukemia / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D007945:Leukemia, Lymphoid / Q000276:immunology; D008223:Lymphoma / Q000276:immunology; D008875:Middle Aged; D010641:Phenotype; D011817:Rabbits; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
D000911:Antibodies, Monoclonal