Rat mast cell degranulation triggered by murine anti-idiotypic antibodies.
Triggering of rat mast cell degranulation by murine anti-idiotypic antibodies (anti-Id) was investigated, using rat passive cutaneous anaphylactic (PCA) reactions as the method of evaluation. It was shown that the interaction between isologous murine anti-Id directed against anti-benzylpenicilloyl (BPO) antibodies and BPO-specific IgE molecules on the cell surface can induce PCA reactions on rats. The mechanism of cell activation by anti-Id was briefly discussed.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000494:pharmacology*; D001667:Binding, Competitive; D003594:Cytoplasmic Granules / Q000276:immunology*; D007073:Immunoglobulin E; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D010323:Passive Cutaneous Anaphylaxis; D010400:Penicillin G / Q000276:immunology; D051381:Rats
D000888:Antibodies, Anti-Idiotypic; D007130:Immunoglobulin Idiotypes; D007073:Immunoglobulin E; D010400:Penicillin G