[Antibodies against soluble nuclear antigens of the SS-A or SS-B type. Significance in systemic lupus erythematosis (author's transl)].
Thirty-five patients with systemic lupus were investigated for serum antibodies specifically directed against soluble proteic nuclear antigens similar to the SS-A and SS-B antigens. The presence of these antibodies did not make much difference in the clinical and biological symptoms of the disease, except for a higher incidence of Gougerot-Sjögren's syndrome with clinical manifestations. Their prevalence in systemic lupus erythematosus was 35%, anti-SS-A antibodies being more frequent than anti-SS-B antibodies (27% and 4,5% respectively). A third different antibody was found in 3% of the patients. These precipitating anti-SS-A or SS-B antibodies have no prognostic significance. They may be present in the absence of antinuclear antibodies detectable by immunofluorescence.
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000209:etiology / Q000276:immunology*
D000974:Antibodies, Antinuclear
Anticorps spécifiques d'antigènes nucléaires solubles de type SS-A et SS-B. Signification au cours de la maladie lupique.