Karyotypic findings and prognosis of adult T-cell leukemia patients.
Twelve patients with abnormal karyotypes out of 18 patients with adult T-cell leukemia died within 5 months on average after initial diagnosis; in contrast, three patients with normal karyotypes are still alive without having received any cancer chemotherapy at 12 to 21 months after diagnosis. The significance of the chromosome abnormality is discussed.
D000328:Adult; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013601:T-Lymphocytes / Q000648:ultrastructure*