Immunoglobulin expression on theta-positive leukemic cells in AKR/J mice.
The expression of surface immunoglobulin was studied on cells of theta-positive AKR leukemia during repeated weekly passages of ascitic cells. It could be shown that the percentage of Ig-positive cells varied considerably (0-25%) and that this was accompanied by variations in the expression of theta-antigen on the cell surface. This was interpreted as repression and derepression of genes coding for surface antigen possibly at the translational level.
D000818:Animals; D001201:Ascites / Q000473:pathology; D007136:Immunoglobulins / Q000032:analysis*; D007938:Leukemia / Q000276:immunology*; D051379:Mice; D008806:Mice, Inbred AKR; D009368:Neoplasm Transplantation; D013499:Surface Properties; D013601:T-Lymphocytes / Q000276:immunology*
D007136:Immunoglobulins