Hapten-specific T cell response to 4-hydroxy-3-nitrophenyl acetyl. X. Characterization of distinct T cell subsets mediating cutaneous sensitivity responses.
NP-O-Succinimide-induced cutaneous sensitivity (CS) responses can be adoptively transferred by NP-primed lymphoid cells into naive K-, I-, or D-compatible recipients. The distinct fine specificities of I- versus D-restricted T cell clones from various strains of mice suggested that presence of different idiotypic receptors on these T cell subsets. We now demonstrate that NP-O-Su immune lymphoid cells are composed of 2 T cell subsets with distinct antigen recognition patterns, as well as different Lyt 2 phenotypes. Thus, I-restricted cells respond to NP-coupled to a protein carrier but not to NP-coupled cells, whereas D-restricted clones react to NP-cells, but not to NP-protein conjugates.
D000818:Animals; D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D006183:H-2 Antigens; D006241:Haptens; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D008198:Lymph Nodes / Q000166:cytology; D051379:Mice; D008810:Mice, Inbred C57BL; D009596:Nitrophenols / Q000494:pharmacology*; D010648:Phenylacetates; D013388:Succinimides / Q000494:pharmacology; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*
D006183:H-2 Antigens; D006241:Haptens; D009596:Nitrophenols; D010648:Phenylacetates; D013388:Succinimides; C026242:4-hydroxy-5-nitrophenyl acetic acid; C026654:4-hydroxy-3-nitrophenylacetyl-O-succinimide ester