Urokinase immobilized on medical polymeric materials: fundamental and clinical studies.
One of the methods of preparing an antithrombogenic material is to immobilize a fibrinolytic enzyme on the surface of a carrier. The clinical trial of such a material must be subject to not only a basic study on the quality of a carrier, the technique of immobilization, and the method of disinfection, but also an in vivo study on its antithrombotic effect. Reported herein is the evaluation of the fibrinolytic ability, at fundamental and clinical levels, of the urokinase that was immobilized on the surface of various polymeric materials. The results were favorable.
D000818:Animals; D002404:Catheterization / Q000295:instrumentation; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D010450:Endopeptidases / Q000494:pharmacology*; D004800:Enzymes, Immobilized / Q000494:pharmacology*; D005337:Fibrin / Q000378:metabolism; D005342:Fibrinolysis; D005343:Fibrinolytic Agents; D006801:Humans; D009757:Nylons; D010969:Plastics; D011091:Polyesters; D011140:Polyurethanes; D011143:Polyvinyl Chloride; D051381:Rats; D013537:Sutures; D014568:Urokinase-Type Plasminogen Activator / Q000494:pharmacology*
D004800:Enzymes, Immobilized; D005343:Fibrinolytic Agents; D009757:Nylons; D010969:Plastics; D011091:Polyesters; D011140:Polyurethanes; D005337:Fibrin; D011143:Polyvinyl Chloride; D010450:Endopeptidases; D014568:Urokinase-Type Plasminogen Activator