title: Immunoreactive trypsin and pancreatic isoamylase activity in serum of patients with chronic renal failure or hepatic cirrhosis.
abstract: In 121 patients with either liver cirrhosis or chronic renal failure, abnormal values for the concentrations of two pancreatic enzymes in serum were a frequent finding. In renal insufficiency a decreased rate of enzyme elimination is the most likely cause of the above-normal values we observed for serum immunoreactive trypsin and pancreatic isoamylase activity. As for patients with liver cirrhosis, we believe that changes in entrance rates into the blood--i.e., an affected pancreas--is a likely explanation of the abnormally high values we often found for these serum enzymes.
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006026:Glycoside Hydrolases / Q000097:blood*; D006801:Humans; D007517:Isoamylase / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000201:enzymology*; D008103:Liver Cirrhosis / Q000097:blood / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000201:enzymology*; D012463:Saliva / Q000201:enzymology; D014357:Trypsin / Q000097:blood*; D000516:alpha-Amylases / Q000097:blood
chemical_list: D006026:Glycoside Hydrolases; D000516:alpha-Amylases; D007517:Isoamylase; D014357:Trypsin