Adjuvant polyarthritis. VI. Effect of oxonate-induced hyperuricemia on the development of acute inflammation, immune response and adjuvant arthritis.
In humans, there is a negative correlation between gout and rheumatoid arthritis. Similarly, rats rendered hyperuricemic by an oxonate diet appeared resistant to develop adjuvant arthritis. These animals exhibited a normal inflammatory response to a subplantar injection of carrageenin and normal humoral and cell-mediated immune responses to a sensitizing dose of EL4 cells. However, unlike that of normal animals, the cell-mediated immune system of the oxonate-treated rats was found to be unable to respond to adjuvant stimulation, which may be the basis for their resistance to develop adjuvant disease.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001168:Arthritis / Q000276:immunology*; D001169:Arthritis, Experimental / Q000276:immunology* / Q000503:physiopathology; D002460:Cell Line; D004032:Diet; D004487:Edema / Q000503:physiopathology; D007111:Immunity, Cellular / Q000187:drug effects; D007249:Inflammation / Q000503:physiopathology; D009374:Neoplasms, Experimental / Q000276:immunology; D010094:Oxonic Acid / Q000494:pharmacology*; D051381:Rats; D011917:Rats, Inbred Lew; D014227:Triazines / Q000494:pharmacology*; D014527:Uric Acid / Q000097:blood* / Q000494:pharmacology
D014227:Triazines; D014527:Uric Acid; D010094:Oxonic Acid