Depression of ventral root--dorsal root potential by DL-alpha-aminoadipate in frog spinal cord.
Ventral root--dorsal root potential (VR--DRP) was partially depressed in the presence of 1 mM DL-alpha-aminoadipate (DL-alpha-AAD), probably corresponding to 0.5 mM D-alpha-AAD, in isolated hemisected frog spinal cord. It was suggested that acidic amino acid receptors might be subserving for the generation of VR--DRP in addition to the initial cholinergic link between motoneurons and interneurons and the electrical coupling between motoneurons and primary afferent terminals and the last step between unidentified interneurons and primary afferent terminals which had been reported to be mediated by GABA.
D015074:2-Aminoadipic Acid / Q000494:pharmacology*; D000344:Afferent Pathways / Q000187:drug effects; D000600:Amino Acids, Dicarboxylic / Q000494:pharmacology*; D000818:Animals; D005071:Evoked Potentials / Q000187:drug effects; D005727:Ganglia, Spinal / Q000187:drug effects; D007395:Interneurons / Q000187:drug effects; D009046:Motor Neurons / Q000187:drug effects; D011892:Rana catesbeiana; D013116:Spinal Cord / Q000187:drug effects*; D013569:Synapses / Q000187:drug effects
D000600:Amino Acids, Dicarboxylic; D015074:2-Aminoadipic Acid