Failure of naloxone to influence plasma growth hormone, prolactin, and cortisol secretions induced by insulin hypoglycemia.
The effect of naloxone, a specific antagonist of opioid peptides, on plasma, GH, PRL, and cortisol responses to insulin-induced hypoglycemia was studied in five healthy male subjects. The iv administration of regular insulin (0.15 U/kg) led to similar degrees of hypoglycemia on control and experimental days. Plasma GH, PRL, and cortisol levels rose significantly in response to insulin-induced hypoglycemia. A 2-h infusion of naloxone (0.8 mg/h) started 30 min before insulin injection did not alter either basal hormone levels or the hormone responses to insulin-induced hypoglycemia. These results suggest that endogenous opioid peptides do not play a major role in GH, PRL, or cortisol secretion induced by insulin hypoglycemia.
D000328:Adult; D004723:Endorphins / Q000502:physiology; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007003:Hypoglycemia / Q000139:chemically induced / Q000503:physiopathology*; D007328:Insulin; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood*
D004723:Endorphins; D007328:Insulin; D009270:Naloxone; D011388:Prolactin; D013006:Growth Hormone; D006854:Hydrocortisone