General practitioners' evaluation of side-effects and efficacy of oxamethacin as compared with indomethacin.
Sixteen general practitioners conducted a multicentre double-blind clinical trial to compare oxamethacin (100 mg t.i.d.) with indomethacin (50 mg t.i.d.) for a maximum duration of 2 weeks. Each drug was administered to 339 patients suffering from various pathological conditions requiring a non-steroidal anti-inflammatory drug. When focusing on patients without associated drug therapy, 126/259 patients (50%) presented a good response on inflammation under oxamethacin and 98/236 patients (42%) a good response under indomethacin (p less than 10(-2)); 141/250 patients (56%) presented a good response on pain under oxamethacin and 117/236 (50%) under indomethacin (p less than 5.10(-2)). Side effects and complaints were reported by 34/250 patients (14%) under oxamethacin and by 67/236 (28%) under indomethacin (p less than 5.10(-5)). Some patients stopped treatment because of side-effects: 14/250 (6%) under oxamethacin and 32/236 (14%) under indomethacin (p less than 2.10(-3)).
D000704:Analysis of Variance; D002214:Capsules; D002986:Clinical Trials as Topic; D004064:Digestive System / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009420:Nervous System / Q000187:drug effects; D010821:Physicians, Family
D002214:Capsules; C019028:oxamethacin; D007213:Indomethacin