Effect of the antidepressant drug-Stelazine on lymphocyte capping.
The antidepressant agent, Stelazine (trifluoroperazine dihydrochloride), is known to cause inactivation of the calcium-binding protein, calmodulin. We report here that this drug in the concentration range of 5 x 10(-5) M to 10(-6) M causes remarkable inhibitory effets on ligand-induced T-lymphocyte receptor capping. The possible involvement of calmodulin in the regulation of lymphocyte surface receptor movement is therefore implicated.
D000818:Animals; D002135:Calcium-Binding Proteins / Q000502:physiology*; D002147:Calmodulin / Q000502:physiology*; D002460:Cell Line; D007152:Immunologic Capping / Q000187:drug effects*; D008223:Lymphoma; D051379:Mice; D008806:Mice, Inbred AKR; D009374:Neoplasms, Experimental; D013601:T-Lymphocytes / Q000187:drug effects*; D014268:Trifluoperazine / Q000494:pharmacology*
D002135:Calcium-Binding Proteins; D002147:Calmodulin; D014268:Trifluoperazine