Generation of F1 hybrid cytotoxic T lymphocytes specific for self H-2.
Cytotoxic T lymphocytes specific for self H-2 antigens are generated by murine F1 hybrid (H-2 heterozygous) spleen cells cultured with irradiated parental (H-2 homozygous) splenocytes. The effectors bind to heterozygous and homozygous cells bearing the appropriate H-2 alleles but only lyse homozygous targets. Autoreactivity for membrane-bound molecules of normal cells may be a mechanism for regulating cellular interactions.
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D006183:H-2 Antigens; D006579:Heterozygote; D006720:Homozygote; D007111:Immunity, Cellular; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D006183:H-2 Antigens