Selective induction of T-cell subsets capable of accelerating and retarding Lewis lung carcinoma.
The influence of three T-cell subsets on tumor growth was studied. The first, induced by a thymic microenvironmental fraction, accelerated the appearance of Lewis lung carcinoma in Winn assay. The second subset, derived from the first by incubation with a thymic hormone preparation, had a marked retarding effect on tumor appearance. The third subset, also induced by thymic hormone, but directly from bone marrow precursors, does not appear to influence tumor cells.
D000818:Animals; D008175:Lung Neoplasms / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000276:immunology; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology*; D013951:Thymus Hormones / Q000502:physiology
D013951:Thymus Hormones