Octanol and octanoate induced inhibition of the mechanical activity of isolated frog skeletal muscles.
Octanol (1 mM) or octanoate (10 mM) almost totally depress the contraction amplitude of directly stimulated muscles in a few minutes. Octanoate in a concentration of 2 mM/l decreases the contraction amplitude by 20% and retards the caffeine contracture. The ratio between twitch and tetanus is affected by octanol only. The results suggest that octanol and octanoate alter binding or releasing properties for Ca2+ of skeletal muscle cells.
D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D002210:Caprylates / Q000494:pharmacology*; D004347:Drug Interactions; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects*; D000442:Octanols / Q000494:pharmacology*; D011893:Rana esculenta
D002210:Caprylates; D000442:Octanols; D002110:Caffeine; D002118:Calcium