A long-lasting enhancing effect of anti-tuberculin antiserum on delayed-type hypersensitivity reaction in BCG-infected guinea pigs.
Anti-tuberculin serum and anti-BCG immunoglobulins from immunized guinea pigs were transferred into recipient guinea pigs which had been infected with BCG. An enhancement of tuberculin skin reactivity was observed 7 and 35 days after transfer of homologous antiserum in comparison to a control group. This indicates a modulating effect of humoral factors, presumably specific antibodies on the expression of delayed-type hypersensitivity reaction after immunostimulation with BCG.
D000818:Animals; D004890:Erythema / Q000175:diagnosis; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007106:Immune Sera / Q000494:pharmacology*; D007116:Immunization, Passive; D008297:Male; D009163:Mycobacterium bovis / Q000276:immunology; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors; D014373:Tuberculin / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology*
D007106:Immune Sera; D014373:Tuberculin