Effects of adult F1 thymocytes on graft-versus-host splenomegaly and homing of parental normal and cortisone-resistant thymocytes in F1 neonates.
In Simonsen assays parental cortisone-resistant thymocytes (P-CRTs) accounted for all of the thymic graft-versus-host reactivity (GVHR) of 3- to 6-week-old BALB/c males in (C3H X BALB/c) (CBF1) neonatal recipients. In the course of these studies, it was observed that coinjection of P-CRTs with large numbers of normal CBF1 thymocytes (F1 NTs) significantly reduced the GVHR of the P-CRTs as measured in Simonsen splenomegaly and [3H]TdR splenic proliferation assays. Homing experiments indicate that one explanation for the reduction in GVHR was a specific decrease in the homing of P-CRTs to spleens of F1 neonatal hosts when P-CRTs were coinjected with F1 NTs.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D003348:Cortisone / Q000494:pharmacology*; D004351:Drug Resistance; D005260:Female; D006087:Graft vs Host Reaction; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D013154:Spleen / Q000166:cytology; D013163:Splenomegaly / Q000209:etiology* / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000637:transplantation
D003348:Cortisone