The synthesis of dihydroxylated vitamin D metabolites by human renal mitochondria.
Mitochondrial preparations from 4 human kidneys produced 1,25-dihydroxycholecalciferol and 24,25 dihydroxycholecalciferol at rates of 0.019 - 0.114 and 0.029 - 0.164 pmol/mg/min respectively at a 25-hydroxycholecalciferol concentration of 1 mumol per litre. Mitochondria from a fifth kidney failed to produce either metabolite.
D015650:24,25-Dihydroxyvitamin D 3; D002117:Calcitriol; D004100:Dihydroxycholecalciferols / Q000096:biosynthesis*; D006801:Humans; D006887:Hydroxycholecalciferols / Q000096:biosynthesis*; D007668:Kidney / Q000378:metabolism*; D007700:Kinetics; D008928:Mitochondria / Q000378:metabolism*
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D015650:24,25-Dihydroxyvitamin D 3; D002117:Calcitriol