Angioimmunoblastic lymphadenopathy in a patient taking diphenylhydantoin.
The premise that chronic antigenic stimulation may be involved in lymphoproliferative disorders was considered in a patient with angioimmunoblastic lymphadenopathy who had received diphenylhydantoin (DPH) for seizure. This patient had clinical features overlapping with systemic lupus erythematosus (SLE) and serum antibody directed against DPH. It was proposed that the syndrome was caused by chronic antigenic stimulation with DPH.
D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D005260:Female; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D010672:Phenytoin / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy
D000974:Antibodies, Antinuclear; D010672:Phenytoin