Lectin(s) extracted from seeds of Artocarpus integrifolia (jackfruit): potent and selective stimulator(s) of distinct human T and B cell functions.
A lectin activity that selectively induces different functions of human lymphocytes has been described in a PBS crude extract obtained from the seeds of Artocarpus integrifolia (jackfruit). Both unfractionated peripheral blood mononuclear cells and purified T cells are strongly stimulated to proliferate by this extract, whereas purified B cells are not. However, the lectin induced a potent polyclonal activation of B cells measured by a reverse hemolytic plaque assay using a multivalent anti-human Fab antibody.
D001402:B-Lymphocytes / Q000276:immunology*; D002999:Clone Cells / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis; D037102:Lectins / Q000494:pharmacology*; D008213:Lymphocyte Activation; D037121:Plant Lectins; D012639:Seeds; D013601:T-Lymphocytes / Q000276:immunology*
D007136:Immunoglobulins; D037102:Lectins; D037121:Plant Lectins