Role of substantia nigra pars reticulata neurons in the expression of neuroleptic-induced catalepsy.
Bilateral kainate-induced lesions of the substantia nigra prevented or dramatically reduced the catalepsy produced by haloperidol. In contrast, infusion of 1 or 4 micrograms 6-OHDA in the medial forebrain bundle, which decreased striatal DA by 30% and 80% respectively, failed to affect or actually potentiated haloperidol catalepsy. Since intranigral kainate, in contrast to 6-OHDA, destroys pars reticulata neurons it appears that these neurons are essential for the expression of haloperidol-catalepsy.
D000818:Animals; D002375:Catalepsy / Q000139:chemically induced*; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D006892:Hydroxydopamines / Q000494:pharmacology; D007608:Kainic Acid / Q000633:toxicity; D008297:Male; D008474:Medial Forebrain Bundle / Q000187:drug effects; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D005680:gamma-Aminobutyric Acid; D006220:Haloperidol; D007608:Kainic Acid; D004298:Dopamine