The effect of mineralocorticoid administration on urine free dopamine in man.
1. Five normal subjects were studied under metabolic conditions on a controlled sodium and potassium intake. 2. Plasma and urine free dopamine concentrations were measured in these subjects before, during and after 5 days administration of fludrocortisone (0.2 mg twice daily). 3. Urine free dopamine showed a tendency to fall during the early phase of fludrocortisone administration and then rose towards normal. 4. In a patient with primary hyperaldosteronism there was no evidence of increased renal production of dopamine. Urine dopamine fell when plasma renin activity rose as a result of spironolactone administration (200 mg three times a day for 5 days). 5. If renal dopamine has a role in mineralocorticoid 'escape' then it may be permissive only. The mechanisms of control of dopamine production could include tubular sodium concentration, tubular chloride concentration and intrarenal renin activity.
D000328:Adult; D001835:Body Weight / Q000187:drug effects; D004298:Dopamine / Q000097:blood / Q000652:urine*; D005438:Fludrocortisone / Q000494:pharmacology*; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000652:urine; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011188:Potassium / Q000652:urine; D012083:Renin / Q000097:blood; D012964:Sodium / Q000652:urine; D013148:Spironolactone / Q000494:pharmacology
D013148:Spironolactone; D012964:Sodium; D012083:Renin; D011188:Potassium; D005438:Fludrocortisone; D004298:Dopamine