[Tissue distribution of 9, 3"-diacetylmidecamycin in the pregnant rat and in the rat following repeated administration (author's transl)].
The tissue distribution of 9, 3"-diacetylmidecamycin (MOM) was studied in the pregnant rats and in the rats following repeated administration. After oral administration of MOM (200 mg/kg) in the pregnant rats, the levels in the placenta and in the uterus were 2-3 times higher than that in the blood, however the levels in the amniotic fluid and in the fetus were 1/10-1/20 of the blood levels. After the third administration of MOM in the first day (30 mg/kg p.o./dose, 3 times/day, 4-hour interval), the levels in the liver, kidney, lungs, spleen, salivary glands and thymus were 1.5-12 times higher than that in the blood; the level in the muscle was almost equal to that in the blood; and the levels in the brain were 1/3-1/10 of the blood level. The tissue distribution patterns after repeated administrations were found to be similar to those of the first day administrations.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D007933:Leucomycins / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D008297:Male; D008431:Maternal-Fetal Exchange; D015644:Miocamycin; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D000900:Anti-Bacterial Agents; D007933:Leucomycins; D015644:Miocamycin