Immunological abnormalities in psoriatic arthropathy.
Immunological parameters were studied in 25 cases of psoriatic arthropathy. We found in the peripheral blood an increase of IgA, a decrease of IgM, and low conentrations of immune complexes. Anti-gammaglobulin factors, mainly of the IgG class, were detected by indirect immunofluorescence in 55.5% of cases. The study of lymphocyte membrane markers showed a decrease of T cells as investigated by E and "active" E-rosettes, a decrease of EA gamma-rosette-forming cells, and an increase of "high avidity" EA-rosettes. Lymphocyte responses to phytomitogens were normal. There was no correlation between the clinical data and the immunolgical features.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D001168:Arthritis / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000276:immunology*; D011961:Receptors, Fc / Q000276:immunology; D012397:Rosette Formation
D000888:Antibodies, Anti-Idiotypic; D011961:Receptors, Fc