[Percentage of lymphocytes carrying receptors to complement 3 (EAC-RFC) and to Fc-fragment of IgG (Tgamma-lymphocytes) in the thymus and spleen of human fetus].
Adequate procedures were used to study the percentage of EAC-RFC and T gamma-cells in the thymus and spleen of 22 human fetuses aged 11-28 weeks obtained as a result of spontaneous abortions. It was established that the content of EAC-RFC in the thymus of the fetuses examined does not exceed 1% on the average in all periods of the ontogenesis, which corresponds with the number of Ig+-cells in the organ. The content of T gamma-cells in the spleen of the fetuses obtained in the course of spontaneous abortions ranges within from 1% on the average (weeks 11-14 of the ontogenesis) to 5.6% (weeks 24-28 of the prenatal ontogenesis). This number is far less as compared to that of such cells in the spleens of adult man (45%) and fetuses obtained as a result of criminal abortions (18-31%). It is suggested that the decreased number of T gamma-cells may play a role in the pathogenesis of spontaneous abortions and miscarriages.
D001402:B-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D003176:Complement C3 / Q000032:analysis; D005333:Fetus; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007958:Leukocyte Count; D011951:Receptors, Complement / Q000032:analysis*; D011961:Receptors, Fc / Q000032:analysis*; D012397:Rosette Formation; D013154:Spleen; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland
D003176:Complement C3; D007074:Immunoglobulin G; D011951:Receptors, Complement; D011961:Receptors, Fc
Protsentnoe soderzhanie limfotsitov, imeiushchikh retseptory k tret'emu fragmentu komplementa (EAS-ROK) i FC-fragmentu IgG (Tgamma-limfotsity) v timuse i selezenke ploda cheloveka.