New chemotherapeutic nitroheterocycles active against 5-nitroimidazole-resistant strains of trichomonads.
The synthesis and the trichomonacidal activity of some 4-substituted 2-imidazolylquinazoline derivatives are described. The new compounds were highly active against metronidazole-sensitive and metronidazole-resistant strains of trichomonads. This was demonstrated in vitro as well as in various trichomoniasis models in mice and rats after oral treatment.
D000818:Animals; D000994:Antitrichomonal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004352:Drug Resistance, Microbial; D005260:Female; D051379:Mice; D009593:Nitroimidazoles / Q000494:pharmacology*; D011799:Quinazolines / Q000494:pharmacology*; D051381:Rats; D014244:Trichomonas / Q000187:drug effects*; D014247:Trichomonas Vaginitis / Q000188:drug therapy; D014246:Trichomonas vaginalis / Q000187:drug effects
D000994:Antitrichomonal Agents; D009593:Nitroimidazoles; D011799:Quinazolines