[Inhibitory action of urogastrone from pregnant horses urine on gastric acid secretion (author's transl)].
Inhibitory actions of urogastrone (UG) on gastric acid secretion induced by tetragastrin (TG), histamine (Hist) and carbachol (Cach) were compared with cimetidine (Cime), atropine (Atr), prostaglandin E2 (PGE2) and epidermal growth factor (EGF) in acute conscious fistula rats. The inhibitory actions of UG were TG greater than Cach greater than or equal to Hist; those of Cime, Cach greater than TG greater than or equal to Hist; those of Atr or PGE2, Cach greater than TG greater than Hist; and those of EGF, TG greater than Hist greater than or equal to Cach. The times required for the maximal inhibition were faster in the order of EGF greater than Cime greater than Atr greater than UG on TG and Hist; Cime greater than EGF=Atr greater than UG on Cach. After vagotomy, the type of inhibition of UG changed to that of Atr and Cach was more evidently inhibited than methacholine by UG. The above data suggest that the inhibitory actions of UG or EGF on gastrin are more specific than Cime, Atr or PGE2 and inhibitory action of UG is slower and longer than Cime, Atr, PGE2 or EGF.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002217:Carbachol / Q000037:antagonists & inhibitors; D002927:Cimetidine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism*; D006633:Histamine Antagonists; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats; D013758:Tetragastrin / Q000037:antagonists & inhibitors; D014628:Vagotomy
D006633:Histamine Antagonists; D011458:Prostaglandins E; D013758:Tetragastrin; D004815:Epidermal Growth Factor; D001285:Atropine; D002927:Cimetidine; D002217:Carbachol