Levels of anti-A and anti-B in commercial immune globulins.
Samples from 168 lots of immune serum globulin, tetanus immune globulin, and Rho (D) immune globulin produced by seven American manufacturers during the period 1973-1977 were analyzed for anti-A and anti-B content by saline and antiglobulin titration. There was appreciable variation among manufacturers, but between 1973 and 1975 all products showed a significant decrease in alloantibody titer. This trend did not continue during the interval 1975-1977; the titers of most manufacturers' products remained near the 1975 level. The anti-A titer of a given product was approximately one dilution higher than the anti-B; both titers were usually increased by anti-human serum, though this occurred more often in the case of anti-B.
D000017:ABO Blood-Group System; D003017:Clostridium tetani / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins; D007518:Isoantibodies; D012965:Sodium Chloride
D000017:ABO Blood-Group System; D007136:Immunoglobulins; D007518:Isoantibodies; D012965:Sodium Chloride