Analysis of oral suspensions containing sulfonamides in combination with erythromycin ethylsuccinate.
The sulfonamides and erythromycin ethylsuccinate in combination oral suspensions were determined by high-performance liquid chromatography and automated turbidimetry, respectively. The chromatographic procedure was rapid, specific, and stability-indicating for sulfisoxazole acetyl and the trisulfapyrimidines using a reversed-phase system with UV detection at 254 nm. Erythromycin ethylsuccinate did not interfere with the sulfonamide analysis and these compounds were assayed with relative standard deviations (RDS) ranging from +/- 2.1 to +/- 3.1%. Erythromycin ethylsuccinate was determined as erythromycin with RSD values of +/- 1.3 or 3.5% without interference by the sulfonamides present.
D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004338:Drug Combinations; D004355:Drug Stability; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000032:analysis; D015643:Erythromycin Ethylsuccinate; D009391:Nephelometry and Turbidimetry / Q000379:methods; D011199:Potentiometry / Q000379:methods; D013449:Sulfonamides / Q000032:analysis*; D013535:Suspensions / Q000032:analysis
D004338:Drug Combinations; D013449:Sulfonamides; D013535:Suspensions; D015643:Erythromycin Ethylsuccinate; D004917:Erythromycin