title: Effect of folate compounds on the accumulation of methotrexate and the activity of dihydrofolate reductase in liver, kidney and small intestine of the mouse.
mesh_terms: D000818:Animals; D002384:Catalysis; D005492:Folic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D007421:Intestine, Small / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D002955:Leucovorin / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008727:Methotrexate / Q000378:metabolism*; D051379:Mice; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*; D013763:Tetrahydrofolates / Q000494:pharmacology
chemical_list: D013763:Tetrahydrofolates; D005492:Folic Acid; D013762:Tetrahydrofolate Dehydrogenase; D002955:Leucovorin; C005984:5-methyltetrahydrofolate; D008727:Methotrexate