Drug-induced pancreatitis: a critical review.
We critically reviewed the English language literature pertaining to drug-induced pancreatitis and attempted to determine whether the reported association between each drug and pancreatitis was valid. The following drugs seem to cause pancreatitis: azathioprine, thiazides, sulfonamides, furosemide, estrogens, and tetracycline. Less convincing, but suggestive evidence exists for: 1-asparaginase, iatrogenic hypercalcemia, chlorthalidine, corticosteroids, ethacrynic acid, phenformin, and procainamide. Evidence implicating other drugs is either inadequate or contradictory. Little is known about the pathogenesis of drug-induced pancreatitis. Ethanol was not considered in this review.
D000082:Acetaminophen / Q000009:adverse effects; D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000662:Amphetamines / Q000009:adverse effects; D001215:Asparaginase / Q000009:adverse effects; D001379:Azathioprine / Q000009:adverse effects; D002752:Chlorthalidone / Q000009:adverse effects; D002792:Cholestyramine Resin / Q000009:adverse effects; D002927:Cimetidine / Q000009:adverse effects; D003533:Cyproheptadine / Q000009:adverse effects; D011431:Dextropropoxyphene / Q000009:adverse effects; D003981:Diazoxide / Q000009:adverse effects; D004232:Diuretics; D004967:Estrogens / Q000009:adverse effects; D004976:Ethacrynic Acid / Q000009:adverse effects; D005665:Furosemide / Q000009:adverse effects; D006632:Histamine / Q000009:adverse effects; D006801:Humans; D006934:Hypercalcemia / Q000150:complications; D007213:Indomethacin / Q000009:adverse effects; D007538:Isoniazid / Q000009:adverse effects; D015122:Mercaptopurine / Q000009:adverse effects; D009294:Narcotics / Q000009:adverse effects; D010195:Pancreatitis / Q000139:chemically induced*; D010629:Phenformin / Q000009:adverse effects; D011342:Procainamide / Q000009:adverse effects; D012293:Rifampin / Q000009:adverse effects; D012459:Salicylates / Q000009:adverse effects; D049993:Sodium Chloride Symporter Inhibitors / Q000009:adverse effects; D013449:Sulfonamides / Q000009:adverse effects; D013752:Tetracycline / Q000009:adverse effects
D000305:Adrenal Cortex Hormones; D000662:Amphetamines; D004232:Diuretics; D004967:Estrogens; D009294:Narcotics; D012459:Salicylates; D049993:Sodium Chloride Symporter Inhibitors; D013449:Sulfonamides; D002792:Cholestyramine Resin; D003533:Cyproheptadine; D000082:Acetaminophen; D005665:Furosemide; D002927:Cimetidine; D006632:Histamine; D010629:Phenformin; D015122:Mercaptopurine; D001215:Asparaginase; D013752:Tetracycline; D011342:Procainamide; D004976:Ethacrynic Acid; D001379:Azathioprine; D003981:Diazoxide; D002752:Chlorthalidone; D011431:Dextropropoxyphene; D007538:Isoniazid; D012293:Rifampin; D007213:Indomethacin