Plasmodium chabaudi-infection of mice: effects of chloroquine and mefloquine. Inhibition of ornithine decarboxylase activity.
Ornithine decarboxylase activity was inhibited in Plasmodium chabaudi-infected red cells of mice treated with chloroquine, mefloquine, primaquine and floxacrine. In vitro experiments on membrane-bound enzymes performed with intact P. chabaudi-infected red cells and corresponding ghost preparations showed a stimulation of NA+K+-ATP'ase and Ca2+Mg2+-ATP'ase activity in the presence of chloroquine, mefloquine and floxacrine.
D000166:Acridines / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D002738:Chloroquine / Q000494:pharmacology*; D004794:Enzyme Repression; D004910:Erythrocyte Membrane / Q000201:enzymology; D008288:Malaria / Q000201:enzymology*; D015767:Mefloquine; D051379:Mice; D065108:Ornithine Decarboxylase Inhibitors; D010880:Piperidines / Q000494:pharmacology*; D010961:Plasmodium / Q000187:drug effects / Q000201:enzymology; D011319:Primaquine / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology*
D000166:Acridines; D000962:Antimalarials; D065108:Ornithine Decarboxylase Inhibitors; D010880:Piperidines; D011804:Quinolines; D002738:Chloroquine; D002262:Carboxy-Lyases; D011319:Primaquine; D015767:Mefloquine; C022008:floxacrine