Interstitial lung disease in polymyositis and dermatomyositis.
An increased frequency of diffuse interstitial lung disease (DILD) was found in 7 of 15 cases of polymyositis and dermatomyositis seen in a 7-yr period. Affected patients had higher values of creatine phosphokinase and aldolase and more severe muscle necrosis than 8 patients with DILD. Early corticosteroid therapy sufficient to normalize enzymes apparently led to better resolutions of DILD. Active muscle necrosis seemed to be related to the development of DILD.
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear; D003402:Creatine Kinase / Q000097:blood; D003882:Dermatomyositis / Q000150:complications* / Q000188:drug therapy; D004576:Electromyography; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000150:complications* / Q000188:drug therapy; D011658:Pulmonary Fibrosis / Q000150:complications* / Q000188:drug therapy; D013902:Radiography, Thoracic; D012129:Respiratory Function Tests; D012217:Rheumatoid Factor
D000305:Adrenal Cortex Hormones; D000974:Antibodies, Antinuclear; D012217:Rheumatoid Factor; D003402:Creatine Kinase; D005634:Fructose-Bisphosphate Aldolase