Ganglioside and monosaccharide inhibition of nonspecific lymphocyte mitogenicity by group A streptococcal pyrogenic exotoxins.
Group A streptococcal pyrogenic exotoxins (SPE) types A, B, and C are potent nonspecific lymphocyte mitogens. The mitogenicity of these exotoxins was inhibited by gangliosides and sialic acid, whereas concanavalin A was unaffected. The capacity of both concanavalin A and SPE-A to stimulate lymphocytes was suppressed by alpha-methyl-D-mannopyranoside. Galactose reduced the activity of SPE-C. The sugars, glucose, N-acetylglucosamine, alpha-methyl-D-glucopyranoside, and fucose, did not affect SPE mitogenicity.
D005098:Exotoxins / Q000494:pharmacology*; D005732:Gangliosides / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008934:Mitogens; D009005:Monosaccharides / Q000494:pharmacology*; D011749:Pyrogens / Q000276:immunology; D013297:Streptococcus pyogenes / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects
D005098:Exotoxins; D005732:Gangliosides; D008934:Mitogens; D009005:Monosaccharides; D011749:Pyrogens