[Effect of multiple administrations of hydrocortisone on the functional activity and morphological characteristics of motor neurons].
Effects of repeated (for 5 days) injections of hydrocortisone (HC) per 1 mg dialy was studied using frogs Rana temporaria. The functional and morphological parameters of spinal motoneurones were investigated. The repeated administrations of HC diminished the excitability of spinal elements, prolonged the latency, and decreased the amplitude of ventral root potentials in response to single stimula applied to dorsal roots. Simultaneously, some structural changes occurred in motoneurones examined: swelling of the cytoplasm and the nucleus, chromatolysis of cell processes, nucleolar hypertrophy, increase in glycogen granule density, swelling of synapses. A suggestion is made that the repeated hormone administration caused in nervous cells some destructive changes of exhaustive type.
D000818:Animals; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D006854:Hydrocortisone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D009046:Motor Neurons / Q000187:drug effects*; D011896:Rana temporaria; D013569:Synapses / Q000187:drug effects; D013997:Time Factors
C007133:hydrocortisone hemisuccinate; D006854:Hydrocortisone
Vliianie mnogokratnykh vvedenii gidrokortizona na funktsional'nuiu aktivnost' i morfologicheskie kharakteristiki motoneĭronov.