[Genetic and epigenetic control of adenosine deaminase expression. Analysis of human and man-mouse hybrid cells (author's transl)].
Analysis of human-rodent hybrids showed the following: the assignment of the ADA1 structural gene to chromosome 20; the identification in hybrids of a new ADA, referred to as ADAx, with a migration more rapidly anodal than ADAd and less rapidly anodal than ADA1 (product of allele 1 or 2); ADAx and d are formed by ADA1 and ADCP (an adenosine deaminase complexing protein). ADCP synthesis is controlled, at least, by a gene (ADCP2) localized on chromosome 2, probably in the IDH1 region; the combined action of another gene (ADCP1), assigned by other authors to chromosome 6, could be neither proved nor disproved, if this gene exists, it must be on 6p or in the 6qter region; the presence of chromosomes 20, 2, and 6 does not constitute a sufficient condition for the formation of ADAx and d, in either the hybrids or the human strains or lines: other factors intervene in its formation, i.e., an interaction between the culture medium, the human parental strain or line, and the rodent parental line.
D000243:Adenosine Deaminase / Q000235:genetics*; D000818:Animals; D002874:Chromosome Mapping; D002900:Chromosomes, Human, 1-3; D002903:Chromosomes, Human, 19-20; D002906:Chromosomes, Human, 6-12 and X; D006224:Cricetinae; D005347:Fibroblasts / Q000166:cytology; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D009700:Nucleoside Deaminases / Q000235:genetics*
D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase
Contrôle génétique et épigénétique de l'expression de l'adénosine désaminase. Analyse des cellules humaines et hybrides homme-rongeur.