Alloreactive and H-2-restricted Lyt 23 cytotoxic T lymphocytes derive from a common pool of antecedent Lyt 123 precursors.
If the collaborative requirement of Lyt 1 T helper cells is bypassed by the Lyt 1 T cell-derived mediator of T help, termed Il-2, upon antigenic stimulation, PNA+ Lyt 123 thymocytes differentiate into either alloreactive or H-2-restricted PNA- Lyt 23 cytotoxic effector cells. Along the differentiation pathway from Lyt 123 leads to 23 effector cells, cytolytic activity is carried out by T cells that still express the Lyt 123 phenotype. The data establish that Lyt 23 CTL are produced by differentiation from antecedent Lyt 123 cells.
D000818:Animals; D002454:Cell Differentiation; D003602:Cytotoxicity, Immunologic; D006183:H-2 Antigens / Q000235:genetics*; D007106:Immune Sera / Q000276:immunology; D007519:Isoantigens / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D011975:Receptors, Mitogen / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology
D006183:H-2 Antigens; D007106:Immune Sera; D007519:Isoantigens; D011975:Receptors, Mitogen