title: On mechanisms of activation and restriction in T and B lymphocytes.
abstract: The mechanism of MHC restriction is discussed with special reference to cytotoxic T lymphocytes reactive against hapten-modified self determinants. Effector cell specificity is considered to reflect the specificity of primary induction and recognition between T lymphocytes and immunogenic antigenic determinants. Mechanisms of activation and development of different specificity repertoires in T and in B cells are discussed, with special reference to those self determinants that direct specificity and serve as markers for self-nonself discrimination.
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D008285:Major Histocompatibility Complex; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell