title: Rat major histocompatibility RT1.C antigens of restricted tissue distribution consist of two polypeptide chains with molecular weights of about 42 000 and 12 500.
abstract: The RT1.C region has recently been defined genetically as a third region of the rat major histocompatibility system, RT1, and has been shown to code for cell-surface antigens with restricted tissue distribution (present on lymphocytes and absent from red blood cells and liver) and for target antigens of unrestricted cytotoxic T lymphocytes. Immunoprecipitation with C-antigen-specific alloantisera and SDS-PAGE analysis, reveal that C-region products are glycoproteins composed of molecules of 40 500-43 000 and 12 500 molecular weight, respectively. Thus, the RT1.B region, which codes for class II molecules, is flanked by RT1 regions which determine class I molecules (as defined biochemically), which are either expressed ubiquitously (RT1.A antigens) or in a restricted manner (RT1.C products). The homology to H-2Qa antigens is discussed.
mesh_terms: D000818:Animals; D006649:Histocompatibility Antigens / Q000302:isolation & purification*; D008285:Major Histocompatibility Complex; D008970:Molecular Weight; D010455:Peptides / Q000302:isolation & purification; D051381:Rats; D011917:Rats, Inbred Lew; D014018:Tissue Distribution
chemical_list: D006649:Histocompatibility Antigens; D010455:Peptides