Evaluation of a new anti-inflammatory/analgesic compound F-776, 5-(4-chlorophenyl)-beta-hydroxy-2-furanpropanoic acid.
F-776, 5-(4-chlorophenyl)-beta-hydroxy-2-furanpropanoic acid, is a nonsteroidal anti-inflammatory, analgesic, and antipyretic drug which does not produce stomach ulcers. It's spectrum of activity includes full anti-inflammatory efficacy in bilaterally adrenalectomized rats; and ED50 value in the carrageenin hindpaw edema assay comparable to that of fenoprofen and ibuprofen; effectiveness in preventing and in diminishing developing and established adjuvant-induced polyarthritis in rats, respectively; significant reduction of granulation tissue formation around cotton pellets; significant decrease in erythema resulting from ultraviolet irradiation of guinea-pig skin; analgesia as determined in the rat paw pressure procedure; antipyretic activity in rats with yeast-induced fever; and an uricosuric effect noted at higher than anti-inflammatory doses. F-776 is not an immunosuppressant as determined in the experimental allergic encephalomyelitis rat model. Its mechanism of action is as yet undetermined. In conclusion, F-776 represents a new nonulcerogenic anti-inflammatory, analgesic, and antipyretic compound with potential utility in different arthritic conditions.
D000315:Adrenalectomy; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy; D004487:Edema / Q000188:drug therapy; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy; D004890:Erythema / Q000188:drug therapy; D005753:Gastric Mucosa / Q000187:drug effects; D006099:Granuloma / Q000188:drug therapy; D006168:Guinea Pigs; D008297:Male; D011422:Propionates / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D014528:Uricosuric Agents
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; D014528:Uricosuric Agents; C024876:orpanoxin