Metabolism of arachidonic acid in inflamed human gingivae. I.: Formation of 6-keto-prostaglandin F1 alpha.
Incubation of [14C]-arachidonic acid with slices of inflamed human gingivae in the absence of glutathione resulted in formation of 6-keto-PGF1 alpha, the stable hydrolytic product of prostacyclin. Significantly smaller amounts of this product were obtained when normal gingivae were treated in a similar manner. The formation of prostacyclin in inflamed gingivae may play an important role in alveolar bone resorption and as a mediator of inflammation in periodontal disease.
D001095:Arachidonic Acids / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002845:Chromatography / Q000379:methods; D002855:Chromatography, Thin Layer; D011464:Epoprostenol / Q000096:biosynthesis*; D005881:Gingiva / Q000378:metabolism; D005891:Gingivitis / Q000378:metabolism*; D006801:Humans; D011453:Prostaglandins / Q000096:biosynthesis*; D011460:Prostaglandins F / Q000096:biosynthesis*
D001095:Arachidonic Acids; D002250:Carbon Radioisotopes; D011453:Prostaglandins; D011460:Prostaglandins F; D011464:Epoprostenol