The toxicity of p-benzoquinone on the central nervous system of the cockroach.
The behavioural symptoms of acute-p-benzoquinone intoxication in the cockroach were shown to be an initial excitation followed by rigid paralysis. p-Benzoquinone produced a depolarization of the postsynaptic membrane of the giant neurones in the 6th abdominal ganglion of the cockroach which was accompanied by an increase in the electrically evoked excitatory postsynaptic potential. The frequency and amplitude of unitary postsynaptic potentials also increased. These effects may be due to inhibition of active cation transport, as illustrated here on the frog isolated skin.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D016227:Benzoquinones; D002490:Central Nervous System / Q000187:drug effects*; D003058:Cockroaches / Q000187:drug effects*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D011809:Quinones / Q000378:metabolism / Q000633:toxicity*; D011896:Rana temporaria; D012879:Skin Physiological Phenomena; D013569:Synapses / Q000187:drug effects
D016227:Benzoquinones; D011809:Quinones; C004532:quinone