title: Liver-spleen imaging in patients with subacute hepatic necrosis and chronic hepatitis.
abstract: Tc-99m-sulfur colloid reticuloendothelial images and percutaneous liver biopsies are correlated in 54 patients who presented with signs and symptoms of subacute hepatic necrosis or chronic active hepatitis. The scored Tc-99m-sulfur colloid scan is compared to the histological severity of disease. Serial scans and biopsies are compared. In patients with significant hepatocellular disease, the liver-spleen scan did not correlate well with the histological severity of disease. Changes in the spleen-to-liver ratio are more common than those in the liver or increased bone marrow activity, and appear earlier. In serial studies, changes in the Tc-99m-sulfur colloid scans correlate weakly with changes in histology.
mesh_terms: D001707:Biopsy, Needle; D001853:Bone Marrow / Q000000981:diagnostic imaging / Q000473:pathology; D003102:Colloids; D006505:Hepatitis / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D006652:Histological Techniques; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D009336:Necrosis; D011877:Radionuclide Imaging; D013154:Spleen / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D013455:Sulfur; D013667:Technetium / Q000378:metabolism
chemical_list: D003102:Colloids; D013455:Sulfur; D013667:Technetium