The effect of co-trimoxazole on serum creatinine.
1 Co-trimoxazole induces a highly significant and reversible elevation of the serum creatinine level. 2 In renal-allograft patients the degree of this elevation is significantly correlated with the concentration of serum creatinine before administration of co-trimoxazole and with the concentration of non-protein-bound trimethoprim.
D000890:Anti-Infective Agents / Q000494:pharmacology*; D003404:Creatinine / Q000097:blood*; D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D013420:Sulfamethoxazole / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D000890:Anti-Infective Agents; D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D003404:Creatinine; D013420:Sulfamethoxazole