title: In vitro lymphocyte reactivity to rubella antigen following vaccination.
abstract: In vitro lymphocyte stimulation and several serological tests were used to study the development of immunity after subcutaneous immunization with attenuated rubella virus. Maximal lymphocyte reactivity was obtained 3--4 months after vaccination and a decline after 1.5--2.5 years. Lymphocyte reactivity following natural immunity was of a higher magnitude. No correlation between the degree of lymphocyte stimulation and titers of neutralizing, hemagglutination inhibiting and hemolysis-in-gel antibodies was observed. The influence on the results of some methodological factors and different rubella antigens is discussed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral; D002469:Cell Separation; D005260:Female; D006801:Humans; D007158:Immunologic Techniques; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008875:Middle Aged; D012411:Rubella Vaccine / Q000276:immunology; D012412:Rubella virus / Q000276:immunology*; D013997:Time Factors; D014613:Vaccines, Attenuated
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D012411:Rubella Vaccine; D014613:Vaccines, Attenuated