The effect of indomethacin on isoprenaline-induced renin secretion in the cat.
In vivo isoprenaline infusion (0.1 micrograms/kg.min)) into the renal artery of unilaterally nephrectomized cats elicited a 5-fold increase in plasma renin concentration (PRC). This increase was suppressed by concomitant administration of propranolol (0.3 mg/kg.min). Indomethacin (250 micrograms/kg.min) intrarenally infused prior to the administration of isoprenaline, abolished the isoprenaline-induced increase in PRC. It is suggested that prostaglandins mediate beta-adrenergic-activated renin release.
D000818:Animals; D002415:Cats; D005260:Female; D007213:Indomethacin / Q000494:pharmacology*; D007545:Isoproterenol / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D009392:Nephrectomy; D012083:Renin / Q000378:metabolism*; D013997:Time Factors
D012083:Renin; D007545:Isoproterenol; D007213:Indomethacin