Lymphocyte subpopulations in peripheral blood and cerebrospinal fluid from patients with acute optic neuritis.
Ten patients with acute optic neuritis (AON) were examined for T and B lymphocytes in blood and cerebrospinal fluid by means of rosette techniques. The percentage of T lymphocytes in blood was significantly decreased (54+/-3%) compared to controls (66+/-2%). Absolute numbers of T lymphocytes, and relative and absolute B lymphocyte concentrations were not significantly different from controls. The cerebrospinal fluid (CSF) T lymphocyte percentage was significantly increased (88.8% compared to 78.0% in controls). The relative CSF immunoglobulin G concentration was elevated in four patients (40%). On agarose gel electrophoresis, bands in the gamma globulin region were found in two patients (20%).
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes; D002555:Cerebrospinal Fluid / Q000166:cytology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007958:Leukocyte Count; D008214:Lymphocytes / Q000145:classification*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology; D009902:Optic Neuritis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes
D007074:Immunoglobulin G