Effects of acute exercise on insulin binding to monocytes in obesity.
The effect of 3 hr of cycle erogmeter exercise on 125I-insulin binding to monocytes was studied in obese and 10 nonobese control subjects. In the basal state before exercise, total specific 125I-insulin binding to monocytes in obese subjects (4.8% +/- 0.3%) was 25% lower than in control subjects (6.6% +/- 0.4%, p less than 0.01). During exercise, insulin binding increased in both groups (p less than 0.05), but the rise in obese subjects was minimal (13% +/- 1%) and was 60%--70% lower than in controls (36% +/- 3%, p less than 0.01). The data indicate that the increment in insulin binding to monocytes induced by acute exercise is diminished in obesity.
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D005934:Glucagon / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood*; D007659:Ketones / Q000097:blood; D007773:Lactates / Q000097:blood; D008297:Male; D009000:Monocytes / Q000378:metabolism*; D009765:Obesity / Q000097:blood*; D005082:Physical Exertion; D011972:Receptor, Insulin / Q000378:metabolism
D001786:Blood Glucose; D007328:Insulin; D007659:Ketones; D007773:Lactates; D005934:Glucagon; D011972:Receptor, Insulin