Vincristine in the etiology of toxicity of high-dose methotrexate therapy.
A 14-year-old received a six-hour infusion of methotrexate (71/2 g/M2) with vincristine (2 mg) and citrovorum rescue according to a standard protocol for adjunctive chemotherapy of osteogenic sarcoma. Signs of mild vincristine toxicity occurred from 2-5 days following the infusion; these including jaw pain, decreases in deep tendon reflexes, and a transient ileus. Clearance of serum methotrexate was delayed during the period of ileus and severe methotrexate toxicity was observed.
D000293:Adolescent; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D006801:Humans; D007263:Infusions, Parenteral; D007415:Intestinal Obstruction / Q000139:chemically induced; D007420:Intestine, Large; D002955:Leucovorin / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage* / Q000633:toxicity; D012516:Osteosarcoma / Q000188:drug therapy; D012026:Reflex, Stretch / Q000187:drug effects; D014750:Vincristine / Q000008:administration & dosage* / Q000009:adverse effects
D004338:Drug Combinations; D014750:Vincristine; D002955:Leucovorin; D008727:Methotrexate