The influence of the thymus on precursor T cells.
The influence of the thymus on its bone marrow precursors was investigated: T cell differentiation was studied in irradiated mice reconstituted with bone marrow from thymectomized donors. Up to twelve months after TX the influx of precursors and differentiation into T cells were not changed in the recipients. CFU-s determination of bone marrow and spleen from thymectomized animals did not show a change in numbers but during ageing a shift of the E/G ratio was observed in thymectomized as well as control donors.
D000818:Animals; D002454:Cell Differentiation; D003114:Colony-Forming Units Assay; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000166:cytology*; D013934:Thymectomy; D013950:Thymus Gland / Q000502:physiology*