Lack of effect of multiple oral doses of meclofenamic acid on parturition in goats.
Daily oral doses of 500 mg meclofenamic acid, a potent inhibitor of prostaglandin biosynthesis, had no observable effects on parturition in goats. These findings are contrary to previous studies in the goat and other animals, but may be a result of the route of meclofenamate administration.
D000818:Animals; D015237:Dinoprost; D005260:Female; D005865:Gestational Age; D006041:Goats / Q000502:physiology*; D007743:Labor, Obstetric / Q000187:drug effects*; D008469:Meclofenamic Acid / Q000097:blood / Q000494:pharmacology*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011460:Prostaglandins F / Q000097:blood; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D011460:Prostaglandins F; D062367:ortho-Aminobenzoates; D008469:Meclofenamic Acid; D011374:Progesterone; D015237:Dinoprost