[Bioelectric correlates of the brain's protective mechanisms].
The author substantiates the necessity of searching for new means producing a therapeutic effect on the brain of epileptic patients that would be similar, in principle, to the brain's own protective mechanisms. This can be done, in the author's opinion, on the basis of studying the most probable bioelectric equivalents of the protective mechanisms. The author suggests a new method for suppressing the epileptogenic focus. This suppression, close to the physiological one, is effected by applying a weak sinusoidal current to the focus via intracerebrally implanted electrodes. Data on the suppression of the epileptiform activity within the zone of the current application, as well as data confirming the local character of the current action are presented. The place of the new method in the system of complex therapy, particularly of epilepsy, is determined with consideration of the role of the stable pathological state. Probable neurophysiological mechanisms of the sinusoidal current action on the epileptogenic focus are discussed.
D000679:Amygdala / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology*; D004599:Electric Stimulation Therapy; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology* / Q000628:therapy; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008297:Male; D013702:Temporal Lobe / Q000503:physiopathology
Bioélektricheskie korreliaty zashchitnykh mekhanizmov mozga.