Further studies on the immunosuppressive effects of indomethacin.
Oral administration of indomethacin inhibited immune response to sheep red blood cells in mice as assessed by direct plaque-forming cells. Serum titers, subsequent to immunization with Pseudomonas aeruginosa lipopolysaccharide, were also diminished in the indomethacin-treated mice. These effects were independent of both the antigen used as well as the magnitude of the primary immune response obtained. Prostaglandins are suggested to play a positive role in in vivo B cell proliferation and function.
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011453:Prostaglandins / Q000096:biosynthesis / Q000502:physiology; D012756:Sheep; D013601:T-Lymphocytes / Q000187:drug effects
D007166:Immunosuppressive Agents; D011453:Prostaglandins; D007213:Indomethacin