title: A hypothesis on the etiology of adult T-cell leukemia/lymphoma.
abstract: The results of the nationwide survey performed by the T- and B-cell Malignancy Study Group revealed that adult T-cell leukemia/lymphoma (ATLL) was prevalent in limited zones in Kyushu, mainly in coastal areas, warm in winter and humid in summer. It was found that the geographical distribution of filariasis was very similar to that of ATLL. It is known that filariasis affects lymphatic vessels and results in several lymphoreticular ailments, and microfilaria is transmitted by mosquitoes infected with some kinds of not yet fully identified viruses. From analyses of the time trends of the average weight and height of school children by prefecture, it is suggested that the nutritional condition of inhabitants in Kyushu might have been poorer than that of inhabitants of other areas in Japan, especially in the past. In order to elucidate the etiology of ATLL, relevant geographic-pathological information and other related information was accumulated and an etiological hypothesis was formulated. It was hypothesised that repeated exposure to filarial antigen and some viruses might have played an important role in the etiology of ATLL and that undernutrition had also contributed to the progression of ATLL.
mesh_terms: D000328:Adult; D003710:Demography; D005368:Filariasis / Q000150:complications; D006801:Humans; D007564:Japan; D007938:Leukemia / Q000453:epidemiology / Q000209:etiology*; D008223:Lymphoma / Q000453:epidemiology / Q000209:etiology*; D009748:Nutrition Disorders / Q000150:complications; D012306:Risk; D013601:T-Lymphocytes / Q000502:physiology*; D013950:Thymus Gland / Q000502:physiology