Congenitally athymic nude (nu/nu) mice have Thy-1-bearing immunocompetent helper T cells in their peritoneal cavity.
Heavily irradiated peritoneal cells (PC) from congenitally athymic nude (nu/nu) mice markedly restored the impaired in vitro antibody response of nu/nu spleen cells to sheep erythrocyte antigens (T-dependent antigen), whereas irradiated spleen or lymph node cells from nu/nu mice had no effect on the response. This activity of the irradiated PC of nu/nu mice was completely abolished by treatment with anti-Thy-1.2 antiserum plus normal guinea pig serum (C') and is, therefore, attributable to a function of matured T cells.
D000818:Animals; D000917:Antibody Formation; D001202:Ascitic Fluid / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation; D007519:Isoantigens / Q000032:analysis; D008211:Lymphocyte Cooperation; D051379:Mice; D008819:Mice, Nude / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
D007519:Isoantigens