title: The percentage of T- and B-cells in the lymphomyeloid tissue of hyperimmunized bursaless chickens.
abstract: Bursa or bursa follicles failed to develop when 3-day-old embryonated eggs were dipped in 2% testosterone propionate in ethanol. The chicks from the treated and control eggs (TP-chicks) were hyperimmunized with sheep red blood cells and the percentages of thymus-derived (T) and bursal-derived (B) lymphocytes in different lymphoid organs determined. The percentage of T-cells in the thymus of TP-embryos was not significantly affected, but the B-cell population was significantly depressed. The percentage of B-cells in peripheral blood, spleen, and bone marrow of TP-hyperimmunized chickens was significantly below that of controls. These data support previous observations of B-cells in bursaless birds. The significantly higher percentage of T-cells in the bone marrow of TP-birds is discussed in relation to T-suppressor cells.
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D001854:Bone Marrow Cells; D002060:Bursa of Fabricius / Q000187:drug effects / Q000276:immunology*; D002642:Chick Embryo; D002645:Chickens / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D004912:Erythrocytes / Q000276:immunology; D007114:Immunization / Q000662:veterinary; D008208:Lymphatic System / Q000166:cytology*; D012756:Sheep / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology*; D013739:Testosterone / Q000494:pharmacology
chemical_list: D013739:Testosterone