Alpha-1-protease inhibitor phenotypes in Australia.
Alpha-1-protease inhibitor (alpha-1-antitrypsin) phenotypes of 1,007 white Australian blood donors, 597 Aboriginals and 63 Vietnamese immigrants were examined by isoelectric focussing in a pH range of 3.5--5.0. The infrequency of the PIM2 allele was high in the Aboriginal populations and low in the blood donors and Vietnamese. The S allele was higher in one Aboriginal group than in the blood donors but very low or absent in the rest. The Z allele was also absent in the northern Aboriginals. Other alleles found in low frequency were PII in the blood donors and the PIF in the Aborigines, with PIX in Aborigines, Vietnamese and blood donors.
D000483:Alleles; D001315:Australia; D001782:Blood Donors; D005787:Gene Frequency; D006801:Humans; D007525:Isoelectric Focusing; D010641:Phenotype; D014744:Vietnam / Q000208:ethnology; D000515:alpha 1-Antitrypsin / Q000235:genetics; D019896:alpha 1-Antitrypsin Deficiency; D000095283:Australian Aboriginal and Torres Strait Islander Peoples
D000515:alpha 1-Antitrypsin