Ia antigen on the surface of a subfraction of T cells that bear Fc receptors for IgG.
Human peripheral blood T cells and T cell subpopulations were studied for the presence of Ia-like antigen, by using indirect immunofluorescence with heterologous rabbit anti-Ia antisera. In 13 normal subjects the percentage of T cells staining with the anti-Ia reagent was 2 to 5% and appeared limited to the T gamma subfraction. After concanavalin A (Con A) or phytohemagglutinin (PHA) activation, the proportion of Ia(+) T cells increased due to an increase in the percentage of T gamma cells bearing Ia-like antigen as well as an increase in the proportion of T gamma cells in the T cell fraction.
D000818:Animals; D000954:Antigens, Surface; D002455:Cell Division; D006649:Histocompatibility Antigens / Q000276:immunology*; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D007074:Immunoglobulin G / Q000276:immunology*; D008934:Mitogens / Q000494:pharmacology; D011817:Rabbits; D011961:Receptors, Fc / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000145:classification* / Q000276:immunology
D000954:Antigens, Surface; D006649:Histocompatibility Antigens; D007106:Immune Sera; D007074:Immunoglobulin G; D008934:Mitogens; D011961:Receptors, Fc