Regulatory role of humoral factors released by macrophages in rat lymphocyte reactivity in vitro. I. Influence of humoral factors released by sensitized peritoneal macrophages on normal lymphocyte reactivity.
Supernatants harvested from cultures of peritoneal macrophages, derived from rats sensitized to bacillary antigens exhibited an intense stimulating effect on syngeneic normal lymph node lymphocytes. Lymphocytes stimulated in this manner showed non-specific cytotoxic activity.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D008222:Lymphokines / Q000276:immunology*; D008264:Macrophages / Q000276:immunology / Q000378:metabolism*; D008297:Male; D051381:Rats
D007376:Interleukin-2; D008222:Lymphokines