Effect of sodium fluoride, calcium carbonate, and vitamin D on the skeleton in multiple myeloma.
Fifteen patients with multiple myeloma were treated with sodium fluoride (50 mg twice daily) plus calcium carbonate (1 g four times daily) or with the same fluoride-calcium dosage plus vitamin D (50,000 U twice weekly). All patients had increased bone formation, as shown by microradiography and videodensitometry. Ten patients had osteosclerosis demonstrated by roentgenograms. Compressive strength of the vertebral bodies was greater among those who received fluoride-calcium than among controls. Densitometry studies were not helpful. Side-effects were minimal and consisted of nausea and fibrositic symptoms. Hypocalcemia occurred less frequently in patients who received vitamin D along with fluoride-calcium. Administration of sodium fluoride and calcium carbonate produces an increase in bone mass and is a useful adjunct treatment for patients with multiple myeloma.
D001847:Bone Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D002119:Calcium Carbonate / Q000008:administration & dosage* / Q000009:adverse effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005459:Fluorides / Q000008:administration & dosage*; D006801:Humans; D009101:Multiple Myeloma / Q000150:complications*; D010919:Placebos; D012969:Sodium Fluoride / Q000008:administration & dosage* / Q000009:adverse effects; D014807:Vitamin D / Q000008:administration & dosage*
D010919:Placebos; D014807:Vitamin D; D012969:Sodium Fluoride; D002119:Calcium Carbonate; D005459:Fluorides