Neonatal suppression with anti-Ia antibody. I. Suppression of murine B lymphocyte development.
To investigate the role of sIa in B lymphocyte development, mice were injected from birth with hybridoma anti-Ia antibody. There was on the average a 95% reduction in the number of sIgD+ cells, and 85% diminution in the number of sIgM+ cells, a small but significant increase in the number of sIgM+ sIgD- sla- B cells, as well as a dramatic increase in the number of sIgM- cells bearing a B lineage antigen. Exposure of cells to high doses of anti-Ia antibody in vitro or in vivo for 24 hr did not affect the number of sIg+ lymphocytes. Thus, it appears that chronic anti-Ia administration critically alters normal B lymphocyte development.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D000954:Antigens, Surface / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D007108:Immune Tolerance; D007518:Isoantibodies; D051379:Mice; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D013154:Spleen / Q000276:immunology
D000954:Antigens, Surface; D000949:Histocompatibility Antigens Class II; D007518:Isoantibodies; D011947:Receptors, Antigen, B-Cell