Modulation of voltage-dependent currents by muscarinic receptor in sympathetic neurones of bullfrog.
The muscarinic actions of acetylcholine (ACh) on the action potentials of bullfrog sympathetic ganglion cells were studied with voltage-clamp experiments. The slow inward current (Isi) carried by Ca2+ was markedly depressed by ACh. ACh also markedly depressed the time-dependent outward current following Isi. The outward current was composed of two components, a TEA-sensitive rectifier K+ current (IK1) and a TEA-insensitive slow rectifier K+ current (IK2). Both of these components were depressed by ACh.
D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004553:Electric Conductivity; D005728:Ganglia, Sympathetic / Q000187:drug effects; D009474:Neurons / Q000502:physiology*; D011892:Rana catesbeiana / Q000502:physiology*; D011950:Receptors, Cholinergic / Q000502:physiology*; D011976:Receptors, Muscarinic / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000166:cytology*; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology
D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D013757:Tetraethylammonium Compounds; D013779:Tetrodotoxin; D019789:Tetraethylammonium; D000109:Acetylcholine