Circulating immune complexes, serum immunoglobulins, and acute phase proteins in psoriasis and psoriatic arthritis.
Raised levels of circulating immune complexes were found in the plasma of 47% of patients with psoriasis and in 58% of those with psoriatic arthritis. The mean levels were significantly raised when compared with normals, but there was no difference between the 2 patient groups. The levels of acute phase proteins (C-reactive protein, fibrinogen, alpha-1-antitrypsin, and the 9th component of complement) were normal in those patients with psoriasis but were significantly raised in patients with psoriatic arthritis. Serum immunoglobulin G and A levels were equally raised in both patient groups, immunoglobulin M being normal. C-reactive protein and fibrinogen gave the best correlation with the clinical index of disease activity.
D000936:Antigen-Antibody Complex / Q000032:analysis*; D001168:Arthritis / Q000097:blood / Q000209:etiology / Q000276:immunology*; D002097:C-Reactive Protein / Q000032:analysis; D003186:Complement C9 / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D011565:Psoriasis / Q000097:blood / Q000150:complications / Q000276:immunology*; D000515:alpha 1-Antitrypsin / Q000032:analysis
D000936:Antigen-Antibody Complex; D003186:Complement C9; D007136:Immunoglobulins; D000515:alpha 1-Antitrypsin; D005340:Fibrinogen; D002097:C-Reactive Protein