Mutagenesis by photoaffinity labeling using selected azidofluorenes.
Several 2-azidofluorenes have been synthesized for use as photoaffinity labels inside bacteria. In the dark they were not mutagenic for any Salmonella typhimurium tested. When photolyzed inside the bacteria, all were mutagenic for strain TA1538 to varying degrees, and were considerably less mutagenic in the corresponding repair positive TA1978. None were mutagenic for strain TA1535 or TA1537, although most compounds were toxic for those strains when photolyzed.
D000345:Affinity Labels; D001386:Azides; D004353:Drug Evaluation, Preclinical; D005449:Fluorenes / Q000494:pharmacology*; D005821:Genetic Techniques; D009153:Mutagens; D012486:Salmonella typhimurium / Q000235:genetics
D000345:Affinity Labels; D001386:Azides; D005449:Fluorenes; D009153:Mutagens; C017825:2-azidofluorene