Stimulation of T lymphocytes by protein A from Staphylococcus aureus in B-derived chronic lymphocytic leukaemia.
Peripheral blood lymphocytes from five untreated patients affected with B-derived chronic lymphocytic leukaemia were stimulated by protein A from Staphylococcus aureus. A very strong response (with stimulation indexes as high as 182 and percentages of blast cells as high as 90%) was found in all patients. Lymphocyte marker studies showed that the responding cells were T cells. These results and the well known abnormalities of lymphocyte response to other mitogens suggest a disbalance of T lymphocyte subpopulations in B-CLL.
D001402:B-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology*; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D011961:Receptors, Fc / Q000032:analysis; D012397:Rosette Formation; D013205:Staphylococcal Protein A / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors
D011947:Receptors, Antigen, B-Cell; D011961:Receptors, Fc; D013205:Staphylococcal Protein A