Biochemical analysis of damage induced in yeast by formaldehyde.
Cross-links between DNA and proteins were induced by formaldehyde treatment in yeast cells. This damage can be repaired by post-treatment incubation of cells or protoplasts in nutrient medium. This repair was observed for wild-type cells as well as for a UV-sensitive, excision-deficient mutant (rad1-3), also sensitive to the lethal effect of formaldehyde.
D004260:DNA Repair; D004271:DNA, Fungal / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005557:Formaldehyde / Q000494:pharmacology*; D005656:Fungal Proteins / Q000378:metabolism; D009153:Mutagens; D010641:Phenotype; D012441:Saccharomyces cerevisiae / Q000235:genetics*
D004271:DNA, Fungal; D005656:Fungal Proteins; D009153:Mutagens; D005557:Formaldehyde