Ocular coccidioidomycosis.
Coccidioidomycosis has been recognized as a common systemic disease since the late 1930's. The occurrence of ocular lesions associated with the systemic infection is uncommon. The anterior segment manifestations appear to be a mild hypersensitivity response; the disease may present as a chronic granulomatous iridocyclitis. In the posterior eye, the manifestations may range from asymptomatic focal chorioretinitis (somewhat similar to the peripheral atrophic lesions of the ocular histoplasmosis syndrome) to a fulminating granulomatous process involving the entire eye. The ocular lesions can occur in the asymptomatic form of systemic coccidioidomycosis. Diagnosis may be confirmed by skin tests and serologic tests. Amphotericin B is usually the drug of choice when treatment is required; however, its adverse effects may be severe, and other drugs, notably Miconazole and Ketoconazole, are being investigated as potential alternatives.
D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D001762:Blepharitis / Q000175:diagnosis; D002648:Child; D002833:Choroiditis / Q000175:diagnosis; D003047:Coccidioidomycosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D003231:Conjunctivitis / Q000175:diagnosis; D003315:Cornea; D004285:Dogs; D005128:Eye Diseases / Q000209:etiology*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use; D008297:Male; D008825:Miconazole / Q000627:therapeutic use; D008875:Middle Aged; D009886:Ophthalmoplegia / Q000209:etiology; D012173:Retinitis / Q000175:diagnosis; D012590:Sclera; D014605:Uveitis / Q000175:diagnosis; D014606:Uveitis, Anterior / Q000175:diagnosis
D007093:Imidazoles; D008825:Miconazole; D000666:Amphotericin B