Brain target sites for 1,25-dihydroxyvitamin D3.
Autoradiographic studies with 3H-labeled 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] demonstrate, in certain neurons of rat forebrain, hindbrain, and spinal cord, a nuclear retention and concentration of radioactivity, which can be prevented by treatment with 1,25(OH)2D3, but not with 25-hydroxyvitamin D3. These results indicate the presence of brain receptors in addition to pituitary receptors for 1,25(OH)2D3 and suggest a central modulation of calcium homeostasis and other central effects for this hormone. The existence of a brain-pituitary axis for certain 1,25(OH)2D3-mediated endocrine-autonomic effects is postulated.
D015652:25-Hydroxyvitamin D 2; D000679:Amygdala / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D004100:Dihydroxycholecalciferols / Q000378:metabolism*; D004872:Ergocalciferols / Q000031:analogs & derivatives / Q000378:metabolism; D006706:Homeostasis; D006887:Hydroxycholecalciferols / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000378:metabolism; D051381:Rats; D013116:Spinal Cord / Q000378:metabolism
D004100:Dihydroxycholecalciferols; D004872:Ergocalciferols; D006887:Hydroxycholecalciferols; D015652:25-Hydroxyvitamin D 2; D002118:Calcium