title: Supranuclear palsy of eyelid closure.
abstract: An inability to close the eyes voluntarily while at the same time retaining reflex blinking is described in three patients with Creutzfeldt-Jakob's disease. In one patient it is was an early symptom but in the others it formed part of a generalized spastic paralysis. By analogy with other reports it is deduced that in the case of a supranuclear palsy of this type the site of the lesion is probably in the cortical neurons rather than in the descending motor tracts.
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D010244:Bulbar Palsy, Progressive / Q000503:physiopathology; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*; D005133:Eye Movements; D005141:Eyelid Diseases / Q000503:physiopathology*; D005143:Eyelids / Q000503:physiopathology; D005158:Facial Paralysis / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D012018:Reflex / Q000502:physiology