title: [GLA-protein of bone. Physiologic factor and new biological marker in bone pathology].
abstract: The gamma-carboxyglutamic acid-containing protein (GLA-protein) present in bone has strong affinity for hydroxyapatite crystals and its synthesis is vitamin D-dependent, which suggests that it might play a major role in bone physiology. It is also the first sensitive and specific marker of bone tissue remodelling. Usefulness of GLA-protein determinations in the diagnosis and therapeutic monitoring of bone diseases remains to be demonstrated by further studies.
mesh_terms: D000818:Animals; D001847:Bone Diseases / Q000097:blood*; D001842:Bone and Bones / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000097:blood / Q000502:physiology*; D006801:Humans; D015675:Osteocalcin; D011863:Radioimmunoassay; D051381:Rats; D014807:Vitamin D / Q000502:physiology
chemical_list: D002135:Calcium-Binding Proteins; D015675:Osteocalcin; D014807:Vitamin D
vernacular_title: La GLA-protéine osseuse. Facteur physiologique et nouveau marqueur biologique en pathologie osseuse.