[Role of cyclic nucleotides in the immunomodulating action of histamine in mice].
A study was made of histamine action on different lymphocyte subpopulations of the mouse spleen during sensitization with ovalbumin. Histamine was shown to exert a regulatory action on proliferation of but rapidly depositing fraction of spleen lymphocytes, which corresponds with suppressor T lymphocytes. The line and intensity of histamine action depended on the time of sensitization. In the initial period histamine reduced the proliferation rate, while on day 3 it stimulated the incorporation of labeled thymidine. The action of histamine was realized through the H2-histamine receptors and was mediated by the increased concentration of cAMP in the lymphocytes.
D000818:Animals; D006632:Histamine / Q000276:immunology*; D007114:Immunization; D051379:Mice; D008810:Mice, Inbred C57BL; D009712:Nucleotides, Cyclic / Q000276:immunology*; D011970:Receptors, Histamine H2 / Q000187:drug effects / Q000276:immunology; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D009712:Nucleotides, Cyclic; D011970:Receptors, Histamine H2; D006632:Histamine
Rol' tsiklicheskikh nukleotidov v immunomoduliruiushchem deĭstvii gistamina u mysheĭ.