[T and B lymphocyte subpopulations with HLA-DR surface molecules in rheumatoid arthritis, using a monoclonal lymphocytotoxic antibody. Poorly and highly developed rheumatoid arthritis].
The T and B lymphocyte subpopulations were studied in 46 patients with rheumatoid arthritis using a monoclonal anti I-E/CK antibody produced by cell hybridation. This antibody recognized HLA-DR "cross-reactive" molecules on the lymphocytes it attacked. The percentage of T cells which were HLA-DR positive was not significantly raised. Taking into account the fall in the T lymphocytes seen in the course of rheumatoid arthritis, the proportion of this sub-population does not seem to be altered when taking the overall picture into account. Similarly the B lymphocytes do not seem to be significantly altered. Nevertheless the heterogeneity of the levels found in all the DR positive sub-populations allows us to suppose that rheumatoid arthritis as we recognize it contains immunologically distinct entities.
D000208:Acute Disease; D000954:Antigens, Surface / Q000032:analysis*; D000961:Antilymphocyte Serum; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001402:B-Lymphocytes / Q000145:classification / Q000276:immunology*; D002908:Chronic Disease; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*
D000954:Antigens, Surface; D000961:Antilymphocyte Serum; D006680:HLA Antigens
Etude des sous-populations lymphocytaires T et B à molécules HLA-DR de surface au cours des polyarthrites rhumatoïdes au moyen d'un anticorps monoclonal lymphocytotoxique. Polyarthrite rhumatoïde à faible et forte évolutivité.