title: Anatomical distribution of call antigen expressing cells in normal lymphatic tissue and in lymphomas.
abstract: Anatomical distribution of common acute lymphoblastic leukemia antigen (CALLA) was studied in lymphomas as well as in normal lymphatic organs using the monoclonal antibody VIL-A1. Twelve lymphomas were labelled by VIL-A1. Three of the 12 tumours also had T-cell marker, six lymphomas also showed immunoglobulin staining and only three tumours were pure CALLA lymphomas. Tonsils showed a distinct CALLA labelling of many germinal centre cells and of singular cells in interfollicular T-cell regions. Children's thymuses showed rare distinctly labelled cells in the cortex and medulla and slightly more cortical cells stained faintly by VIL-A1. Foetal thymuses of about the twelfth week of gestation contained many heavily labelled cells. The findings are discussed as evidence for the presence of CALLA on immature B as well as T lymphocytes. They favour the idea of CALLA as a common lymphocyte differentiation antigen although other possibilities of interpretation are also discussed.
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis*; D002454:Cell Differentiation; D005260:Female; D005333:Fetus / Q000032:analysis; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology*; D008208:Lymphatic System / Q000032:analysis*; D008214:Lymphocytes / Q000032:analysis; D008223:Lymphoma / Q000276:immunology*; D014066:Palatine Tonsil / Q000032:analysis; D011247:Pregnancy; D013950:Thymus Gland / Q000032:analysis
chemical_list: D000951:Antigens, Neoplasm