Effect of prolonged immunization of mice with bovine serum albumin on the incidence of chemically induced tumors.
The effect of prolonged immunization of mice with bovine serum albumin (BSA) on tumors elicited by injection of 3-methylcholanthrene was studied. The incidence of tumors and rate of tumor growth were higher in mice immunized with BSA than in control mice injected with syngeneic serum. The possibility of an immunosuppressive effect of the prolonged immunization with BSA is discussed.
D000818:Animals; D000936:Antigen-Antibody Complex; D002417:Cattle; D002471:Cell Transformation, Neoplastic; D006462:Hemolytic Plaque Technique; D007114:Immunization; D007165:Immunosuppression Therapy; D007668:Kidney / Q000276:immunology; D008748:Methylcholanthrene; D051379:Mice; D008809:Mice, Inbred C3H; D009369:Neoplasms / Q000139:chemically induced*; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000276:immunology*; D013997:Time Factors
D000936:Antigen-Antibody Complex; D012710:Serum Albumin, Bovine; D008748:Methylcholanthrene