Congenital primary hypothyroidism and HLA.
Previous studies have suggested an association between congenital hypothyroidism and HLA-Aw24 or B18 antigens. The frequencies of HLA-A, B and C antigens were studied in 33 unrelated Danish patients with congenital hypothyroidism (5 with aplasia of the thyroid gland, 16 with ectopic thyroids and 8 with thyroid dyshormonogenesis). HLA-Aw24 only appeared in patients with ectopic thyroids and HLA-B18 was only seen in patients with dyshormonogenesis. However, the frequencies of HLA antigens in patients and in a large number of controls did not differ statistically significantly. We conclude that HLA typing is without any predictive value in determining the risk of developing or giving birth to a child with congenital hypothyroidism.
D002675:Child, Preschool; D003409:Congenital Hypothyroidism; D003718:Denmark; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006801:Humans; D007037:Hypothyroidism / Q000276:immunology*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D013961:Thyroid Gland / Q000002:abnormalities
D006680:HLA Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens