[Protective and damaging action of cytotoxic T-lymphocytes in experimental tick-borne encephalitis].
The methods of adoptive transfer in vivo and cytotoxic action on virus-infected tissue culture in vitro were used to prove that cytotoxic splenocytes produced in experimental tick-borne encephalitis could have both protective and damaging effects. The protective effect was manifested during the first 24 hours after infection, and the damaging effect on the 6th day after infection. Cytotoxicity splenocytes were identified as T lymphocytes on the basis of their sensitivity to anti-theta serum, resistance to the action of hydrocortisone and their inability to adhere to glass, as well as their pronounced specificity and their limited activity in the allogeneic system.
D000818:Animals; D001102:Arbovirus Infections / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D004675:Encephalitis, Tick-Borne / Q000276:immunology*; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012845:Sindbis Virus; D013045:Species Specificity; D013154:Spleen / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D014184:Transplantation, Homologous; D015004:Yellow Fever / Q000276:immunology
Zashchitnoe i povrezhdaiushchee deĭstvie tsitotoksicheskikh T-limfotsitov pri éksperimental'nom klershchevom éntsefalite.