title: Acute, subacute and chronic toxicity of fosfosal.
abstract: Acute, subacute and chronic toxicity studies of 2-phosphonoxy benzoic acid (fofosal) were carried out in several animal species. LD50 values in mice and rats were determined at two pH values; an additional toxic effect of acidity was found at the lowest pH tested (pH = 1.0), specially so by i.p. route. Differences in LD5- values between mice and rats of either sex were not significant; however, acute toxicity of male rabbits was higher than that of rats and mice. Long-term toxicity studies revealed a slight growth retardation and a significant mortality at the highest dose tested (500 mg/kg). These studies showed that fosfosal produced no hematological, blood chemical or pathological changes.
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D007928:Lethal Dose 50; D009929:Organ Size / Q000187:drug effects; D010755:Organophosphates / Q000633:toxicity*; D009943:Organophosphorus Compounds / Q000633:toxicity*; D051381:Rats; D012459:Salicylates / Q000633:toxicity*; D012737:Sex Factors; D013045:Species Specificity; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010755:Organophosphates; D009943:Organophosphorus Compounds; D012459:Salicylates; C000380:fosfosal