title: Soft-tissue infections of ampicillin-resistant Haemophilus influenzae type b. The use of ampicillin and nafcillin in their treatment.
abstract: The combination of intravenous ampicillin sodium and nafcillin sodium followed by oral ampicillin and dicloxacillin sodium was effective in treating five infants with soft-tissue infections and bacteremia due to beta-lactamase-producing, ampicillin-resistant Haemophilus influenzae type b. This antibiotic combination seems to be an effective alternative to chloramphenicol for treatment of non-meningitic invasive disease due to moderately ampicillin-resistant (minimum inhibitory concentration, 2 to 24 microgram/mL) H influenzae type b. The use of this combination should be in conjunction with appropriate in vitro tests whose results demonstrate synergism.
mesh_terms: D000284:Administration, Oral; D000667:Ampicillin / Q000494:pharmacology*; D002481:Cellulitis / Q000188:drug therapy*; D004009:Dicloxacillin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006192:Haemophilus Infections / Q000188:drug therapy*; D006193:Haemophilus influenzae / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D009254:Nafcillin / Q000627:therapeutic use*; D010403:Penicillin Resistance; D018805:Sepsis / Q000188:drug therapy*
chemical_list: D009254:Nafcillin; D000667:Ampicillin; D004009:Dicloxacillin