Effects of 5-(N,N-diethylamino)-n-pentyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-5) on cardiovascular systems.
The effects of 5-(N,N-diethylamino)-pentyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-5) were studied pharmacologically on smooth muscle, skeletal muscle, blood vessel and cardiac preparations. In all cases, TMB-5 inhibited muscle contractions induced by muscle stimulants such as acetylcholine, norepinephrine, KCl and BaCl2, indicating that the muscle inhibition induced by TMB-5 is unrelated to specific receptors. TMB-5 was found to be most potent in inhibiting skeletal muscles (at 10(-6)-10(-5) M level) and least effective in inhibiting smooth muscles (at 10(-4)-10(-3) M level). The potency of vascular inhibition was in between these two levels (at 10(-4) M level). The ability of TMB-5 to raise the threshold of cardiac arrhythmias was quite good at 7X10(-7)-7X10(-6) M. It is concluded that TMB-5 could be a good antiarrhythmic agent with some skeletal muscle relaxation action.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001011:Aorta / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D002642:Chick Embryo; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D011651:Pulmonary Artery / Q000187:drug effects; D011817:Rabbits; D011894:Rana pipiens; D051381:Rats; D014649:Vas Deferens / Q000187:drug effects
D000889:Anti-Arrhythmia Agents; C035565:5-(N,N-diethylamino)pentyl-3,4,5-trimethoxybenzoate; C006014:8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate; D005707:Gallic Acid