Selective protection against the cytotoxicity of methotrexate and methotrexate-poly(lysine) by thiamine pyrophosphate, heparin and leucovorin.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005347:Fibroblasts; D006493:Heparin / Q000494:pharmacology*; D002955:Leucovorin / Q000494:pharmacology*; D008727:Methotrexate / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000031:analogs & derivatives; D051379:Mice; D010455:Peptides / Q000037:antagonists & inhibitors*; D011107:Polylysine / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000031:analogs & derivatives; D013835:Thiamine Pyrophosphate / Q000494:pharmacology*
D010455:Peptides; D011107:Polylysine; C030305:methotrexate-polylysine; D006493:Heparin; D002955:Leucovorin; D013835:Thiamine Pyrophosphate; D008727:Methotrexate