Single-dose cefuroxime in the prophylaxis of abdominal wound sepsis.
A double-blind study was carried out to investigate the prophylactic use of single-dose cefuroxime in elective abdominal surgery. Twenty-three patients received 1.5 g cefuroxime by intravenous injection immediately prior to induction of anaesthesia; 24 patients received no antibiotics. In the cefuroxime group, there were no cases of post-operative wound sepsis or septicaemia; in the control group, the incidence of these infections was 12.5% and 8.3% respectively.
D000005:Abdomen / Q000601:surgery*; D002444:Cefuroxime / Q000009:adverse effects / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000517:prevention & control*
D002511:Cephalosporins; D002444:Cefuroxime