Neonatal tolerance to alloantigens alters major histocompatibility complex-restricted response patterns.
Male-specific transplantation antigen (H-Y)-immune cytotoxic T cells of some individual CBA/H mice exhibit lytic activity on male and female allogeneic targets (e.g., H-2b). Neonatal tolerance to H-2b abrogates the ability of CBA mice to generate secondary H-Y-immune cytotoxic T cells, but such cell activity to third-party alloantigens and to Bebaru and influenza virus is not impaired. The results are discussed in relationship to dominant major histocompatibility complex-coded immune response gene effects on cytotoxic T-cell responses.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005260:Female; D006183:H-2 Antigens; D006182:H-Y Antigen; D007108:Immune Tolerance; D007111:Immunity, Cellular; D008285:Major Histocompatibility Complex; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology
D006183:H-2 Antigens; D006182:H-Y Antigen