Expression of Ia-like antigen in lymphatic leukaemias and non-hodgkin lymphomas in correlation with other surface markers.
Ia-like antigen, surface Ig, E-rosettes, mouse red blood cell rosettes and further surface markers were investigated in 88 specimens from 69 patients with various lymphocytic leukaemias and non-Hodgkin lymphomas. Ia-like antigen was detectable in all cases of sIg+ leukaemias and lymphomas. E-Ia+sIg-leukaemias, especially CLL and lymphomas were interpreted as B-cell neoplasias, which either did not produce sIg or expressed it in undetectable amounts. E+Ia+sIg+ malignant lymphocytes represented a B-cell population with antibody activity of sIg to SRBC. In the present series 9.5% of all B-cell leukaemias and lymphomas demonstrated this phenotype. Whereas ALL may possess Ia-like antigen, the vast majority of mature T-cell lymphomas are lacking it. In the present series 2 T-cell lymphomas expressed Ia-like antigen and did not contain TdT (E+Ia+sIg-TdT-). These lymphomas are probably derived from a stimulated T-cell clone synthesizing Ia-like antigen.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002417:Cattle; D004253:DNA Nucleotidylexotransferase / Q000032:analysis; D006681:HLA-D Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology*; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology; D051379:Mice; D010641:Phenotype; D011817:Rabbits; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D011971:Receptors, Immunologic / Q000032:analysis; D012397:Rosette Formation
D006681:HLA-D Antigens; D000949:Histocompatibility Antigens Class II; D011947:Receptors, Antigen, B-Cell; D011971:Receptors, Immunologic; D004253:DNA Nucleotidylexotransferase