title: Primary structure of monkey osteocalcin.
abstract: The complete 49-residue amino acid sequence of osteocalcin from the old world monkey Macaca fascicularis has been determined by efficient combination of gas chromatography-mass spectrometry and Edman techniques. This vitamin K dependent protein of bone matrix contains three gamma-carboxyglutamic acid residues at positions 17, 21, and 24, as well as a disulfide-bonded loop (23--29). Features of the sequence which apparently are required for the binding of Ca2+ have been strongly conserved throughout evolution.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001842:Bone and Bones / Q000032:analysis; D002135:Calcium-Binding Proteins / Q000302:isolation & purification; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008252:Macaca fascicularis; D015675:Osteocalcin; D011487:Protein Conformation; D013045:Species Specificity
chemical_list: D002135:Calcium-Binding Proteins; D015675:Osteocalcin