Tumor detection with 1-aminocyclopentane and 1-aminocyclobutane C-11-carboxylic acid using positron emission computerized tomography.
Eight patients with proven or suspected neoplastic lesions were examined with 1-aminocyclobutane C-11-carboxylic acid and 1-aminocyclopentane C-11-carboxylic acid using positron emission computed tomography. The results of this comparative study have shown that both of these unnatural amino acids have a high affinity for malignant tumors. The potential of nonmetabolizable C-11-labeled amino acids as noninvasive indicators of metabolic tumor activity is demonstrated and discussed.
D000596:Amino Acids / Q000378:metabolism; D000598:Amino Acids, Cyclic; D002250:Carbon Radioisotopes; D003515:Cycloleucine / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000000981:diagnostic imaging*; D014055:Tomography, Emission-Computed / Q000379:methods
D000596:Amino Acids; D000598:Amino Acids, Cyclic; D002250:Carbon Radioisotopes; D003515:Cycloleucine; C016987:1-aminocyclobutanecarboxylic acid