In vitro activity of N-formimidoyl thienamycin against 98 clinical isolates of Brucella melitensis compared with those of cefoxitin, rifampin, tetracycline, and co-trimoxazole.
IN vitro susceptibilities of 98 isolates of Brucella melitensis to N-formimidoyl thienamycin, tetracycline, co-trimoxazole, rifampin, and cefoxitin were determined. N-Formimidoyl thienamycin showed good activity which was similar to those of tetracycline and rifampin and different from that of the other beta-lactam antibiotic tested (cefoxitin), which showed poor activity. Co-trimoxazole showed good activity.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002002:Brucella / Q000187:drug effects*; D002006:Brucellosis / Q000382:microbiology; D002440:Cefoxitin / Q000494:pharmacology; D004338:Drug Combinations / Q000494:pharmacology; D006801:Humans; D015378:Imipenem; D007769:Lactams / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D012293:Rifampin / Q000494:pharmacology; D013420:Sulfamethoxazole / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D007769:Lactams; D002440:Cefoxitin; D015378:Imipenem; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013752:Tetracycline; D013420:Sulfamethoxazole; D012293:Rifampin