Self-reactive T cells. IV. Self-reactive T cells induce polyclonal differentiation of IgM-producing B cells in vivo and in vitro.
Intravenous injection of lymphoblasts (generated in vitro by different T- or B-specific mitogens) induced a polyclonal activation of IgM-producing B cells in vivo in the spleens of syngeneic recipient mice. This polyclonal differentiation of host-derived B cells to IgM-producing plaque-forming cells was stimulated by host-derived self-reactive T cells activated in the splenic lymphoid cell population in response to the syngeneic lymphoblast graft. We found a stable factor in the supernatants of cultures of proliferating self-reactive T cells that induced (antigen-independent) polyclonal maturation, but not proliferation of IgM-producing B cells.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D001402:B-Lymphocytes / Q000166:cytology*; D002999:Clone Cells / Q000276:immunology; D003470:Culture Media; D005260:Female; D006736:Horses; D007075:Immunoglobulin M / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D017710:Lymphocyte Transfusion; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D012756:Sheep; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology*; D014301:Trinitrobenzenes / Q000276:immunology
D003470:Culture Media; D007075:Immunoglobulin M; D014301:Trinitrobenzenes