Thymus graft reconstitution of T-cell-deprived mice infected with Trypanosoma musculi.
T-cell-deprived CBA mice were given thymus graft implants during the course of an infection with Trypanosoma musculi and at a time when the parasitaemia was high. As a consequence of the grafts, most of the mice survived the infection whereas control ungrafted mice died. In grafted animals there was generally a period of 60-80 days after grafting during which time parasitic numbers remained high, and a further period of 200 or more days when trypanosomes were still detectable in the circulation. The mice were highly variable in their responses and possible reasons for this are considered.
D000818:Animals; D051379:Mice; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000637:transplantation*; D014345:Trypanosoma / Q000254:growth & development; D014352:Trypanosomiasis / Q000276:immunology* / Q000469:parasitology