[Cellular immunity deficiency and chemotaxis deficiency in children with rheumatoid arthritis].
Some immunological parameters have been examined in eleven children with juvenile rheumatoid arthritis. A quantitative and functional defect in T lymphocytes has been observed associated with defective chemotaxis of neutrophils. High levels of circulating immune-complexes were detected in sera of 5 out 11 patients. 1 patient showed high levels of antinuclear antibodies and positivity for the rheumatoid factor. Immunological pathogenesis of juvenile rheumatoid arthritis is discussed.
D000293:Adolescent; D001171:Arthritis, Juvenile / Q000276:immunology*; D002634:Chemotaxis, Leukocyte; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes; D008213:Lymphocyte Activation; D008297:Male; D009504:Neutrophils; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology
Deficit dell'immunitá cellulare e della chemiotassi in bambini con artrite reumatoide.