title: Silicone rubber substrata: a new wrinkle in the study of cell locomotion.
abstract: When tissue cells are cultured on very thin sheets of cross-linked silicone fluid, the traction forces the cells exert are made visible as elastic distortion and wrinkling of this substratum. Around explants this pattern of wrinkling closely resembles the "center effects" long observed in plasma clots and traditionally attributed to dehydration shrinkage.
mesh_terms: D000818:Animals; D002465:Cell Movement; D002478:Cells, Cultured / Q000502:physiology; D002642:Chick Embryo; D008857:Microscopy, Interference; D008858:Microscopy, Phase-Contrast; D012826:Silicone Elastomers
chemical_list: D012826:Silicone Elastomers