Lymphocyte function and cell-mediated immunity in pigs with experimentally induced African swine fever.
Twenty-five pigs inoculated with African Swine fever virus were studied for the development of changes in lymphocyte numbers and function. The results indicated that lymphopenia and decreased percentage of circulating T-lymphocytes occurred as early as 7 days after the pigs were inoculated. These were accompanied by depressed lymphocyte function, as measured by mitogen- or antigen-induced blastogenesis. There were proportionately greater decreases in T-lymphocyte numbers and function than were found for B-lymphocytes. Studies of phagocytic cell function revealed decreased phagocytic function for peripheral blood monocytes and unchanged (normal) neutrophil function. Depressed T-lymphocyte function occurred in pigs with acute and subacute infections, indicating depression of cellular immune function.
D000135:Acid Phosphatase / Q000378:metabolism; D000357:African Swine Fever / Q000276:immunology*; D000358:African Swine Fever Virus / Q000276:immunology; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology; D007111:Immunity, Cellular; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000166:cytology / Q000201:enzymology / Q000276:immunology*; D010587:Phagocytosis; D013552:Swine; D013601:T-Lymphocytes / Q000276:immunology
D000914:Antibodies, Viral; D000135:Acid Phosphatase