[Demonstration of a subpopulation of T-lymphocytes by a monoclonal lymphocytotoxic antibody produced by cellular hybridization in slightly developed rheumatoid arthritis].
The lymphocytes from 20 cases of mild rheumatoid arthritis have been explored thanks to a monoclonal antibody found in a murine hybridoma of specificity I-E/Ck, "cross-reacting" with the human molecules HLA-DR+. A slight increase in the lymphocyte subpopulation T-DR+ is found, representing 25.15% versus 18.5% of the lymphocytes T isolated by rosettes in the normal subject. These cells correspond to a subpopulation of T lymphocytes whose immunologic function remains to be defined.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000502:physiology*; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D011817:Rabbits; D013601:T-Lymphocytes / Q000145:classification* / Q000276:immunology
D000911:Antibodies, Monoclonal; D006680:HLA Antigens
Mise en évidence d'une sous-population de lymphocytes T par un anticorps monoclonal lymphocytotoxique produit par hybridation cellulaire au cours de polyarthrites rhumatoïdes peu évolutives.