[Factors that control stem cell differentiation. II. The sensitivity of T-differentiated lymphocytes to the action of radiation and cytostatics].
Bone marrow stem cells of the parent genotype (CBA) produce mainly erythroid colonies in the spleen of lethally irradiated recipients (CBA-C57Bl)F1. T d-lymphocytes change this differentiation pattern from the mainly erythroid to the mainly myeloid pathway. The irradiation with 100 R does not abolish this effect. The lymphocytes irradiated in vitro with 200 R or more, and incubated with Mitomycin C or Cycloheximide lost the ability to change the differentiation pattern of the transplanted cells. T d-lymphocytes are radiosensitive cells that need DNA and protein synthesis for realizing their function.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D003513:Cycloheximide / Q000494:pharmacology*; D005720:Gamma Rays; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000528:radiation effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008937:Mitomycins / Q000494:pharmacology*; D011836:Radiation Tolerance; D013601:T-Lymphocytes / Q000187:drug effects / Q000528:radiation effects*
D008937:Mitomycins; D003513:Cycloheximide
Faktory, kontroliruiushchie differentisirovku stvolovykh keltok. II. Chuvstvitel'nost' T-differentsiruiushchikh limfotsitov k deĭstviiu radiatsii i tsitostatikov.