Stimulation of regulatory T cell circuits by immunoglobulin-dependent structures on activated B cells.
An immunoregulatory circuit is described in which B cell blasts activate syngeneic Ly-1+2-3- T cells to (a) start a reaction which is indistinguishable from a graft-vs.-host reaction (syngeneic GvH) and (b) induce suppressor cell activity which abrogates the syngeneic GvH. Since capping the surface immunoglobulin (Ig) on B cell blasts blocks their ability to activate the circuit, it is likely that the relevant cell surface structure "seen" on the B cell by the Ly-1 T cell is either Ig itself or another molecule in association with Ig.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001402:B-Lymphocytes / Q000276:immunology*; D003165:Complement System Proteins; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation; D051379:Mice; D008806:Mice, Inbred AKR; D011817:Rabbits; D011947:Receptors, Antigen, B-Cell; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000961:Antilymphocyte Serum; D011947:Receptors, Antigen, B-Cell; D003520:Cyclophosphamide; D003165:Complement System Proteins