Immunodominance in the immune response to "multiple" histocompatibility antigens.
Cytotoxic effector T cells putatively specific for multiple non-H-2 histocompatibility (H) antigens were generated by immunizing and boosting C57BL/6 and B6.C-H-2d mice with BALB.B and BALB/c stimulator cells, respectively. The generated effectors were tested for cell-mediated lympholysis on a panel of targets whose BALB/c-derived non-H-2 H antigens were donated by CXB recombinant inbred mice. The spectrum of reactivity of cytotoxic effector T cells with CXB targets demonstrated that the effectors did not recognize multiple H antigens but rather preferentially recognized a single immunodominant non-H 2 antigen. The identity of the immunodominant H antigen was determined by the H-2 genotype of the stimulator cells when (B6 x B6.C-H-2d)F1 cytotoxic effectors were tested. These observations indicate that despite the fact that responders were challenged with more than 40 individual non-H-2 H antigens, they preferentially responded to single immunodominant antigen.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D006183:H-2 Antigens / Q000235:genetics; D006649:Histocompatibility Antigens / Q000276:immunology*; D007114:Immunization; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000276:immunology; D008285:Major Histocompatibility Complex; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D006183:H-2 Antigens; D006649:Histocompatibility Antigens