Regulation of B cell immunoglobulin secretion by functional subsets of T lymphocytes in man.
Two distinct immunoregulatory T cell subsets, termed T4+ and T5+, have been defined in man by monoclonal antibodies. Prior studies have shown that the T4+ T cell population provided help for B cell immunoglobulin (Ig) production and was required for generation of T5+ cytotoxic effector cells. In the present study, the regulatory effects of the T5+ T cell subset on B cell Ig secretion were determined in a pokeweed mitogen-driven system. It was found that the T5+ subset, in contrast to the T4+ subset, was incapable of providing help to B cells and, more importantly, could suppress Ig secretion by B cells in the presence of T4+ inducer T cells, Given earlier studies demonstrating that the T5+ T cell subset suppressed T cell responses as well, this population appears to represent the major suppressor subset in man for T-T and T-B interactions.
D000906:Antibodies; D001402:B-Lymphocytes / Q000166:cytology / Q000378:metabolism*; D002454:Cell Differentiation; D002999:Clone Cells / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007136:Immunoglobulins / Q000096:biosynthesis*; D011043:Pokeweed Mitogens / Q000494:pharmacology; D013601:T-Lymphocytes / Q000145:classification*
D000906:Antibodies; D007074:Immunoglobulin G; D007136:Immunoglobulins; D011043:Pokeweed Mitogens