title: [Comparative haemodynamic studies with mexiletine and lidocaine in patients with coronary heart disease after aorto-coronary bypass (author's transl)].
abstract: In two patient groups undergoing coronary surgery (n = 10) hemodynamic side effects of mexiletine and lidocaine were investigated. Changes of clinical importance were seen in cardiac-output, stroke volume, total peripheral resistance, triple- and cardiac index. There are significant differences 10, 15, and 30 min after application (p less than 0.05; p less than 0.025) in cardiac-index.
mesh_terms: D002302:Cardiac Output / Q000187:drug effects; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology*; D008801:Mexiletine / Q000494:pharmacology*; D011437:Propylamines / Q000494:pharmacology*; D013318:Stroke Volume / Q000187:drug effects; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D011437:Propylamines; D008801:Mexiletine; D008012:Lidocaine
vernacular_title: Vergleichende hämodynamische Untersuchungen mit Mexiletine und Lidocain bei Patienten mit koronarer Herzerkrankung nach aorto-koronarem Bypass.