title: Transitory effects of osmotic pressure gradients on acetylcholine release at the neuromuscular junction and on catecholamine secretion at the adrenal gland of the frog.
abstract: When the extracellular solution is abruptly changed from hypertonic to isotonic, the frequency of miniature end-plate potentials at the frog neuromuscular junction, and the secretion of catecholamines from the isolated bullfrog adrenal, are both enhanced transitorily. These findings are consistent with the observations in the liposome-bilayer experiments by Cohen et al. [1, 2]. The mechanisms observed in their experiments may be relevant to the exocytotic release of neurotransmitters and hormones.
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D004594:Electrophysiology; D009045:Motor Endplate / Q000502:physiology; D009469:Neuromuscular Junction / Q000378:metabolism*; D009997:Osmotic Pressure; D011896:Rana temporaria; D013997:Time Factors
chemical_list: D002395:Catecholamines; D000109:Acetylcholine