title: Expression of HLA-DR antigens on T lymphocytes.
abstract: Our data have demonstrated, for the first time, expression of HLA-DR antigens on heated T cells (45 degrees C, 1 h) and have confirmed the occurrence of these antigens on mitogen-stimulated T cells. HLA-DR antigens were detected by microlymphocytotoxicity employing defined and non-defined anti-HLA-DR sera. The HLA-DR T cell antigens proved to be the same as the ones expressed on B cells from the same donor. In addition, extra reactions were observed on mitogen-stimulated and on heated T cells which could be abolished by absorption with cytotoxicity negative B cells of the same donor (cytotoxicity-negative-absorption-positive phenomenon).
mesh_terms: D000042:Absorption; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006358:Hot Temperature; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D008934:Mitogens / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000949:Histocompatibility Antigens Class II; D007106:Immune Sera; D008934:Mitogens