title: Metastatic canine medullary thyroid carcinoma: a case report.
abstract: A medullary carcinoma of the thyroid in a dog first became evident because of a distant metastasis. The histologic characteristics of the tumor differ from those previously reported in dogs in that this tumor was highly malignant; anaplasia and mitotic figures were common. The diagnosis was substantiated by radioimmunoassay for calcitonin. Serotonin and 5-hydroxytryptophan also were elevated in the neoplastic tissue. The relation of the biochemical alterations to the clinical course was not clear.
mesh_terms: D006916:5-Hydroxytryptophan / Q000032:analysis; D000818:Animals; D002116:Calcitonin / Q000032:analysis; D002277:Carcinoma / Q000473:pathology / Q000556:secondary / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004700:Endocrine System Diseases / Q000473:pathology / Q000662:veterinary; D005260:Female; D009369:Neoplasms / Q000662:veterinary; D012701:Serotonin / Q000032:analysis; D013964:Thyroid Neoplasms / Q000473:pathology / Q000662:veterinary*
chemical_list: D012701:Serotonin; D002116:Calcitonin; D006916:5-Hydroxytryptophan