Correlation of hypotensive effect of plasma protein fraction with prekallikrein activator activity: a clinical study in patients having open-heart surgery.
We studied the hemodynamic responses to the administration of 20 ml of three protein solutions having different prekallikrein activator (PKA) activities in patients undergoing cardiac operation. PKA levels of the two plasma protein fraction (PPF) solutions studied were 193% and 60%, respectively, while that of the albumin solution was less than or equal to 3%. A significant correlation was found between the PKA activity of the test solutions and the decrease in systemic vascular resistance produced by the solutions during cardiopulmonary bypass and in the postoperative period. Vasodilatation was considerably more marked in the postoperative phase than during cardiopulmonary bypass. Since cardiac output increased simultaneously with the decrease in vascular resistance in the postoperative period, the hypotension observed did not fully reflect the degree of vasodilatation. In some patients, substantial vasodilatation was observed also after the administration of albumin solution with low PKA level. We conclude that although the PPF-induced vasodilatation correlates with the PKA activity of the solution, occasional hypotensive reactions are probably due to mechanisms other than those linked with increased PKA level.
D000328:Adult; D001798:Blood Proteins / Q000008:administration & dosage*; D005174:Factor XII / Q000008:administration & dosage*; D015956:Factor XIIa; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000209:etiology*; D008875:Middle Aged; D009204:Myocardial Revascularization; D010446:Peptide Fragments / Q000008:administration & dosage*; D011897:Random Allocation; D012709:Serum Albumin / Q000008:administration & dosage*; D014664:Vasodilation
D001798:Blood Proteins; D010446:Peptide Fragments; D012709:Serum Albumin; D005174:Factor XII; D015956:Factor XIIa