Folate metabolism in filariae. Enzymes associated with 5,10-methenyltetrahydrofolate and 10-formyltetrahydrofolate.
Adult Dirofilaria immitis and Brugia pahangi were found to possess the following folate-related enzymes that catalyze the formation of 5,10-methenyltetrahydrofolate (methenylFH4) or 10-formylFH4 (f10FH4): f10FH4 synthetase, methenylFH4 cyclohydrolase, f5FH4 cyclodehydrase, and a bifunctional complex composed of formiminoglutamate: FH4 formiminotransferase and 5-fomiminoFH4 cyclodeaminase. The properties of these filarial enzymes were generally similar to those of their counterparts from invertebrate and vertebrate sources, although each possessed one or more distinctive characteristics.
D000619:Aminohydrolases / Q000378:metabolism; D000642:Ammonia-Lyases / Q000378:metabolism; D000818:Animals; D002009:Brugia / Q000201:enzymology*; D019731:Carbon-Nitrogen Ligases; D004183:Dirofilaria immitis / Q000201:enzymology*; D005370:Filarioidea / Q000201:enzymology*; D005574:Formate-Tetrahydrofolate Ligase / Q000378:metabolism; D005575:Formyltetrahydrofolates / Q000378:metabolism*; D051042:Glutamate Formimidoyltransferase; D019877:Hydroxymethyl and Formyl Transferases; D007700:Kinetics; D002955:Leucovorin / Q000378:metabolism; D008025:Ligases / Q000378:metabolism; D045064:Methenyltetrahydrofolate Cyclohydrolase; D008970:Molecular Weight; D013763:Tetrahydrofolates / Q000378:metabolism*; D014166:Transferases / Q000378:metabolism
D005575:Formyltetrahydrofolates; D013763:Tetrahydrofolates; C013123:5,10-methylenetetrahydrofolic acid; D014166:Transferases; D019877:Hydroxymethyl and Formyl Transferases; D051042:Glutamate Formimidoyltransferase; D000619:Aminohydrolases; D045064:Methenyltetrahydrofolate Cyclohydrolase; D000642:Ammonia-Lyases; C020148:formiminotetrahydrofolate cyclodeaminase; D008025:Ligases; D019731:Carbon-Nitrogen Ligases; C021557:5,10-methenyltetrahydrofolate synthetase; D005574:Formate-Tetrahydrofolate Ligase; D002955:Leucovorin