title: Free fatty acidemia as an inducer of systemic hyperfibrinogenemia and fibrinolytic inhibition.
abstract: Many major inflammatory stimuli induce secondary conditions of blood hyperfibrinogenemia and fibrinolytic inhibition, changes which may be mediated by alterations in free fatty acid (FFA) metabolism. The effect of a free fatty acidemia induced by the intravenous infusion of a triglyceride into rabbits on the fibrinogen/fibrinolytic system was determined. A 3-h infusion of synthetic fat emulsion induced a rapid rise in FFA (0.4-2.1 microEq/ml in 3 h) followed by a more gradual rise in fibrinogen (2.6-4.3 mg/ml at 24 h), alpha 1-antitrypsin (1.1-1.9 mg/ml at 48 h), and serum fibrinolysis inhibitory activity (increased 202% at 48 h). Increases in protein concentration were due to increased synthesis. It is proposed that the changes in the fibrinogen/fibrinolytic system which follow major inflammatory stimuli are induced by a mediating free fatty acidemia. Possible pharmacological procedures to block these changes are discussed.
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000096:biosynthesis; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005340:Fibrinogen / Q000378:metabolism*; D005342:Fibrinolysis / Q000187:drug effects*; D006168:Guinea Pigs; D011817:Rabbits; D012709:Serum Albumin; D013997:Time Factors; D014304:Triolein / Q000494:pharmacology; D000515:alpha 1-Antitrypsin
chemical_list: D001798:Blood Proteins; D005230:Fatty Acids, Nonesterified; D012709:Serum Albumin; D000515:alpha 1-Antitrypsin; D014304:Triolein; D005340:Fibrinogen