Probable mechanism of spleen colony formation suppression with rabbit antimouse brain antiserum.
Syngeneic thymocytes are shown to restore the capacity of bone marrow treated with rabbit antimouse brain (RAMB) serum to form the spleen colonies. The same effect may be exerted by the V fraction of thymosin or endotoxin, but not by allogeneic thymocytes. It is assumed that RAMB serum acts not on the stem cells but rather on another cell population (accessory cells?) contributing to the differentiation.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D004731:Endotoxins / Q000494:pharmacology; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D007106:Immune Sera / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011817:Rabbits; D013601:T-Lymphocytes / Q000502:physiology; D013947:Thymosin / Q000494:pharmacology
D000961:Antilymphocyte Serum; D004731:Endotoxins; D007106:Immune Sera; D013947:Thymosin