[Polyclonal activation of B-lymphocytes by synthetic polyelectrolytes].
A study was made of the ability of polyacrylic acid, poly-4-vinylpyridine, and the copolymers 4-vinylpyridine and 4-vinyl-N-alkylpyridinium bromides with side hydrocarbonic radicals of varying length to induce in mice of different strains B-cell differentiation into the plaque-forming cells without antigenic stimulation. The polyelectrolytes have been shown to favour the transformation of B lymphocytes to the cells that secrete polyclonal antibodies, i.e. to be polyclonal activators of B lymphocytes. B lymphocyte differentiation induced by the polyelectrolytes does not depend on T cells and is liable to genetic restriction.
D000180:Acrylic Resins / Q000494:pharmacology; D000818:Animals; D000921:Antibody-Producing Cells; D001402:B-Lymphocytes / Q000187:drug effects*; D006824:Hybridization, Genetic; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011108:Polymers / Q000494:pharmacology*; D011145:Polyvinyls / Q000494:pharmacology; D011205:Povidone / Q000494:pharmacology
D000180:Acrylic Resins; D011108:Polymers; D011145:Polyvinyls; C006903:carbopol 940; D011205:Povidone
Poliklonal'naia aktivatsiia B-limfotsitov sinteticheskimi poliélektrolitami.