New pharmacologically active 2-phenylpyrazolo [1,5-a]pyrimidines.
2-Phenylpryrazolo [1,5-a]pyrimidine (I) 4,7-dihydro-2-phenylpyrazolo [1,5-a]pyrimidin-7-one (II) and 4,5-dihydro-2-phenylpyrazolo [1,5-a]pyrimidin-5-one (III) are prepared. Because of the interesting antipyretic, hypothermizing and anti-inflammatory properties of some of their derivatives, the above mentioned compounds are used as reference compounds in a Q.S.A.R. study still in progress. Methylation of (II) and (III) with (CH3)2SO4 and CH2N2 gives methylderivatives whose structure is determined by spectroscopic means.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D011744:Pyrimidinones