Effects of single intramuscular administration of various preparations of corticosteroids on bentonite-induced oedema of rat hind paw.
Effects of single prophylactic and/or therapeutic i.m. doses of various esters of anti-inflammatory steroids on the bentonite-induced oedema of the rat paw were followed. The short-lasting actions (1 d) of soluble sodium succinate esters of hydrocortisone, prednisolone and 6-methylprednisolone on the one hand, and the long-lasting actions (1 to 2 weeks) of insoluble hydrocortisone acetate, 6-methylprednisolone acetate or cyclopentylpropionate, and triamcinolone diacetate or acetonide on the other hand have been proved. Both the preparations of beta-methasone tested exerted short-lasting effects (1 d). It has been confirmed that triamcinolone acetonide is more effective (and also more toxic) than the diacetate ester of this steroid. The bentonite-induced oedema has proved to be a suitable model of inflammatory reaction for screening anti-inflammatory corticosteroids because it makes possible the determination and differentiation of the time of onset, intensity and duration of action of single doses of various pharmaceutical formulations of these agents.
D000818:Animals; D001546:Bentonite / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D007273:Injections, Intramuscular; D051381:Rats
D005938:Glucocorticoids; D001546:Bentonite