Influence of age on in vitro effect of cadmium on rat liver cytochrome P-450 concentration and monooxygenases activity.
Cadmium++ added in vitro destroys rat liver cytochrome P-450 (cyt. P-450) with increasing age by 25-50%. Ethylmorphine N-demethylation is inhibited only in rats 30-days old and thereafter. Ethoxycoumarin 0-deethylation is inhibited even in newborn rats, and the maximal inhibition appears to increase with age. It is concluded that in all age groups cadmium resistant cyt. P-450 subspecies are present. Ethoxycoumarin 0-deethylase activity possibly indicates the cadmium sensitive P-450 fraction.
D015660:7-Alkoxycoumarin O-Dealkylase; D000367:Age Factors; D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis*; D005037:Ethylmorphine-N-Demethylase / Q000032:analysis; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010105:Oxygenases / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D002104:Cadmium; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D015660:7-Alkoxycoumarin O-Dealkylase; D005037:Ethylmorphine-N-Demethylase