Evidence for a platelet membrane defect in the myeloproliferative syndromes.
Bleeding and abnormal platelet aggregation occur in patients with myeloproliferative disorders. In this study, twenty patients were examined, some sequentially, and a proportion found to have defective aggregation toward adrenaline, adenosine diphosphate (ADP), and collagen. In these seven patients, the abnormality in platelet response with defective collagen-induced [14C]serotonin release correlated with poor collagen-stimulated thromboxane B2 (TXB2) production. In contrast, five of these patients showed a normal threshold aggregation response to arachidonic acid. The combined results suggest that in these patients, there is a defect between receptor-stimulus coupling and the mobilization of arachidonic acid from membrane phospholipid.
D001792:Blood Platelets / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood; D008563:Membrane Lipids / Q000097:blood*; D009196:Myeloproliferative Disorders / Q000097:blood*; D010974:Platelet Aggregation; D010976:Platelet Count; D011087:Polycythemia Vera / Q000097:blood; D012701:Serotonin / Q000097:blood; D013577:Syndrome; D013922:Thrombocytosis / Q000097:blood; D013929:Thromboxane B2 / Q000096:biosynthesis
D008563:Membrane Lipids; D012701:Serotonin; D013929:Thromboxane B2