title: Blood disoprofol levels in anesthetised patients. Correlation of concentrations after single or repeated doses with hypnotic activity.
abstract: The blood concentrations of disoprofol (Diprivan) after single intravenous doses of 1, 2 or 3 mg/kg have been examined in a subpopulation from previously reported clinical studies. The linear relationship between sleep time and dose could be explained by the linearity of the pharmacokinetics at these doses. After a single injection the awakening concentration was independent of dose, with a mean value of 1.04 micrograms/ml. No acute tolerance occurred with disoprofol. On repeated 1 mg/kg bolus injections the sleeping time rose initially but stabilised after four doses. The waking concentration was independent of the number of doses administered. The clinical findings fitted an agent with a very rapid distribution phase and a short elimination half-life.
mesh_terms: D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007700:Kinetics; D010636:Phenols / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology; D015742:Propofol; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects
chemical_list: D000777:Anesthetics; D010636:Phenols; D015742:Propofol