Immunity in migraine: the effect of heparin.
There is evidence that migraine has an immunologic component. Migraine patients have reduced levels of circulating basophils and T-lymphocytes and there is a negative correlation of T-cell levels and disease activity. Clinical improvement of migraine is observed after the repeated inhalation of heparin in those patients in whom heparin raises both basophil and T-lymphocyte values to the normal range.
D000328:Adult; D001491:Basophils / Q000187:drug effects*; D005260:Female; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D007111:Immunity, Cellular; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy / Q000276:immunology*; D011971:Receptors, Immunologic / Q000032:analysis; D012138:Respiratory Therapy; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011971:Receptors, Immunologic; D006493:Heparin