title: [Non-steroidal antirheumatics: side-effects and interactions].
abstract: Side effects of non-steroidal antirheumatic drugs (NSAD) may occur in any organ system, since the prostaglandins, the synthesis of which is inhibited by NSAD, play a role in numerous adverse cellular processes throughout the body. Besides these physiologic regulations there are adverse effects of NSAD, such as bone marrow aplasia, of unexplained etiology. The interactions of NSAD are of clinical relevance in drug types such as the salicylates, pyrazolons and fenamic acids (e.g. interactions with cumarin derivatives). The clinically relevant interactions of NSAD are discussed in detail.
mesh_terms: D000741:Anemia, Aplastic / Q000139:chemically induced; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000494:pharmacology; D003374:Coumarins / Q000494:pharmacology; D004347:Drug Interactions; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D009288:Naproxen / Q000494:pharmacology; D010653:Phenylbutazone / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis; D012216:Rheumatic Diseases / Q000188:drug therapy*; D012459:Salicylates / Q000494:pharmacology; D013276:Stomach Ulcer / Q000139:chemically induced; D062367:ortho-Aminobenzoates / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003374:Coumarins; D011453:Prostaglandins; D012459:Salicylates; D062367:ortho-Aminobenzoates; D009288:Naproxen; C001209:fenamic acid; D010653:Phenylbutazone; D007213:Indomethacin
vernacular_title: Nicht-steroidale Antirheumatika: Nebenwirkungen und Interaktionen.