Clinical and laboratory features of canine lupus syndromes.
Determination of the specificities of antinuclear antibodies in the sera of 20 dogs presenting with symptoms of a lupus-like syndrome permitted their separation into 2 groups. The first group of 14 dogs all had antibody activity to DNA-histone antigen(s), and 4 of them also had antibodies to native DNA (nDNA). The Farr test with standard buffer was found to be unsatisfactory for the measurement of anti-nDNA antibodies in dog sera due to a high incidence of false positive reactions; these could be eliminated by the inclusion of sodium dodecyl sulfate in the buffer system. The second group of 6 dogs was characterized by the presence of antibodies to extractable nuclear antigen. In every serum tested diseased dogs had a diminished level of circulating thymic factor as compared to controls of the same age, suggesting that a diminution of suppressor T cells may be an etiologic factor.
D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis; D000918:Antibody Specificity; D001323:Autoantibodies / Q000032:analysis; D004247:DNA / Q000276:immunology; D004283:Dog Diseases / Q000175:diagnosis / Q000276:immunology; D004285:Dogs; D005189:False Positive Reactions; D005260:Female; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology / Q000662:veterinary*; D008297:Male; D013935:Thymic Factor, Circulating / Q000032:analysis
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D004247:DNA; D013935:Thymic Factor, Circulating