title: [Antipyretic activity of 3-amino-4-mercapto-6-methylpyridazine and some standard pharmaca].
abstract: The induction of fever in the rat by means of yeast homogenates was used to evaluate the antipyretic activity of several pharmaca. Apart from 3-amino-4-mercapto-6-methylpyridazine (1; pyridazine S1), the author tested acetylsalicylic acid, phenacetin, aminophenazone, phenylbutazone and indometacin. The antipyretic activity of 1 was almost equal to that of aminophenazone. Dose-response relationships provided security for the comparison of the activities of these two pharmaca. The relatively low toxicity of 1 (nearly five times less than that of aminophenazone) was noteworthy. The antipyretic activity of 1 was not inhibited by atropine. The possible central attack mechanisms of pyridazine (which produce a decline of fever) are discussed in connexion with data from the literature.
mesh_terms: D000632:Aminopyrine / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001285:Atropine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000139:chemically induced; D011724:Pyridazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011724:Pyridazines; D000632:Aminopyrine; C034963:3-amino-4-mercapto-6-methylpyridazine; D001285:Atropine
vernacular_title: Antipyretische Wirksamkeit von 3-Amino-4-mercapto-6-methylpyridazin und einiger Standardpharmaka.