title: [Tolerance and acute and subchronic toxicity of flavophospholipol from the Pharmaceutical Chemical Research Institute].
abstract: The single oral application of Flavophospholipol--NIHFI (0.8 per cent premix) at rates with regard to the active ingredient per kg of live weight of 5, 10, and 15 g to albino mice and rats, and 15, 20, and 30 g to week-old broiler birds did not produce toxicity. Besides, it was well tolerated in tests with broiler birds in amounts 50 times as high as the stimulant dose (4 g/t feed). The oral administration with the feed at the rate of 80 g/t to newly hatched broiler chicks in the course of sixty days did not either produce toxic effects or changes whatever in the physiological and biochemical indices studied and in the microstructure of the viscera. It was found to stimulate growth and increase the erythrocyte count. Under the conditions of testing the subchronic toxicity of flavophospholipol amounts of 400 and 2000 g/t feed led to the lowering of the consumption rate and the body weight as well as to the increase in the blood sugar. At 2000 g/t it lowered the amount of hemoglobin in the blood, and partially increased the activity of SGPT.
mesh_terms: D000821:Animal Feed / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D001455:Bambermycins / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D001455:Bambermycins
vernacular_title: Prouchvane vŭrkhu ponosimostta, ostrata i subkhronichnata toksichnost na flavofosfolipol--NIKhFI.