[Antimutagenic action of cellular and humoral immunity factors in cytogenetic disorders of cultured fibroblasts induced by a vaccinal strain of the measles virus].
In the human fibroblast culture media infected with measles virus (strain Leningrad-16), the injection of non-immune autogenic leucocytes and T-lymphocytes was shown to lead to a substantial decrease in fibroblast frequency with alterations in chromosome number and, in a lesser degree, with break in the structure of chromosomes. Immune homogenic leucocytes render an opposite effect. The injection of immune sera stabilized the cell frequency with chromosome aberrations. Non-immune homogenic leucocytes have no antimutagenic activity.
D000917:Antibody Formation; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D005347:Fibroblasts / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007231:Infant, Newborn; D007962:Leukocytes / Q000276:immunology; D008459:Measles virus / Q000472:pathogenicity*; D009154:Mutation; D013601:T-Lymphocytes / Q000276:immunology
Antimutagennaia aktivnost' kletochnykh i gumoral'nykh faktorov immuniteta pri tsitogeneticheskikh narusheniiakh kul'tiviruemykh fibroblastov, indutsirovannykh vaktsinnym shtammom virusa kori.