Chromatic and luminosity processing in retinal disease.
Color vision loss can be an early sign of eye disease; in many retinal disorders the loss precedes any change in visual acuity. Noninvasive psychophysical methods allow factoring out of preretinal, receptoral, and postreceptoral (neural) components of the color vision change. A loss of chromatic but not achromatic sensitivity occurs for diabetics; the loss is selective for pathways subserving blue-sensitive photoreceptors. Both chromatic and achromatic pathways are altered in glaucoma and senile macular degeneration; the most marked change in central serous choroidopathy is loss of sensitivity somewhere in the blue-sensitive cone pathway. There is evidence that the pathways subserved by blue-sensitive cones have anatomically and physiologically different properties from those served by other receptor types, and they appear particularly vulnerable to disturbances of retinal integrity.
D000328:Adult; D003117:Color Vision Defects / Q000150:complications / Q000175:diagnosis*; D003930:Diabetic Retinopathy / Q000175:diagnosis; D005901:Glaucoma / Q000175:diagnosis; D006801:Humans; D008268:Macular Degeneration / Q000175:diagnosis; D008875:Middle Aged; D011601:Psychophysics; D012164:Retinal Diseases / Q000150:complications / Q000175:diagnosis*