Evaluation of the renin-aldosterone system during hypo- and hyperglycemia in children and adolescents.
The effect of hypo- and hyperglycemia on the renin-aldosterone system was studied in 10 endocrinologically normal children. Insulin-induced hypoglycemia caused an elevation of plasma renin activity (PRA) up to 371 +/- 23% (mean +/- SEM) over the basal level (p less than 0.001) and of the plasma aldosterone level up to 243 +/- 7% (mean +/- SEM) over the basal values (p less than 0.001). Hyperglycemia caused an elevation of PRA up to 135 +/- 40% (mean +/- SEM) over the basal values (p less than 0.05) and a reduction in the plasma aldosterone level to 53 +/- 12% (mean +/- SEM, p less than 0.01). It is suggested that the widely used diagnostic procedures, the insulin tolerance and oral glucose tolerance tests, be also applied for the investigation of the renin-aldosterone system.
D000293:Adolescent; D000450:Aldosterone / Q000097:blood*; D002648:Child; D005260:Female; D005947:Glucose; D006801:Humans; D006943:Hyperglycemia / Q000097:blood* / Q000139:chemically induced; D007003:Hypoglycemia / Q000097:blood* / Q000139:chemically induced; D007328:Insulin; D008297:Male; D011188:Potassium / Q000378:metabolism; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000378:metabolism
D007328:Insulin; D000450:Aldosterone; D012964:Sodium; D012083:Renin; D005947:Glucose; D011188:Potassium