SQ 26,180, a novel monobactam. I Taxonomy, fermentation and biological properties.
Strains of Chromobacterium violaceum, isolated from various environments, were found to produce a novel monocyclic beta-lactam antibiotic. The antibiotic, SQ 26,180 was weakly active against Gram-positive and Gram-negative bacteria with the exception of mutants hypersensitive to beta-lactam antibiotics. The compound was highly stable to beta-lactamases and acted as an inhibitor of the P99 enzyme from Enterobacter cloacae. SQ 26,180 showed affinity for penicillin-binding proteins 1a, 4 and 5/6 of Escherichia coli and inhibited R61 DD-carboxypeptidases.
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D001398:Aztreonam / Q000031:analogs & derivatives*; D001419:Bacteria / Q000187:drug effects; D001426:Bacterial Proteins; D002268:Carboxypeptidases / Q000037:antagonists & inhibitors; D002352:Carrier Proteins / Q000378:metabolism; D002861:Chromobacterium / Q000145:classification / Q000378:metabolism*; D005285:Fermentation; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D001618:beta-Lactamases / Q000494:pharmacology; D047090:beta-Lactams / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002352:Carrier Proteins; D046915:Penicillin-Binding Proteins; D047090:beta-Lactams; C033584:SQ 26180; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002268:Carboxypeptidases; D002267:Muramoylpentapeptide Carboxypeptidase; D001618:beta-Lactamases; D001398:Aztreonam