T-lymphocytes and nonspecific T-suppressor activity in patients with extrinsic asthma.
The authors studied the distribution of T-lymphocytes (T-Et and T-Ea) and the nonspecific T-suppressor activity induced by ConA in a group of 104 patients (adults and children) with extrinsic asthma. Comparison with the control group revealed a diminution in the T-Et population (p less than 0.01), no significant change in the T-Ea population and a diminished nonspecific T-suppressor activity (p less than 0.001). The possible role of the T functional deficiency in the development of allergic diathesis is discussed.
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000276:immunology*; D008297:Male; D013491:Suppressor Factors, Immunologic; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*
D008222:Lymphokines; D013491:Suppressor Factors, Immunologic; D003208:Concanavalin A