Lymphocyte adherence to myelinated tissue in multiple sclerosis.
A small subpopulation of human peripheral blood T lymphocytes has the capacity to adhere selectively to myelinated sections of human and nonhuman brain tissue. Adherence of lymphocytes from patients with multiple sclerosis is significantly greater than adherence of control lymphocytes. Monocytes inhibit binding in controls. This function appears to be lost by multiple sclerosis monocytes.
D002448:Cell Adhesion; D005260:Female; D006801:Humans; D008297:Male; D009000:Monocytes / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology*; D009413:Nerve Fibers, Myelinated / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*