Human leukocyte antigen-linked genetic controls for T cell-mediated cytotoxic response to mumps virus in humans.
The involvement of human leukocyte antigen determinants for the response of mumps virus-specific cytotoxic T lymphocytes in humans was studied. The cytotoxic T lymphocytes could only lyse virus-infected allogeneic cells with which they shared a particular human leukocyte antigen, e.g., Bw52 or B7. The existence of Bw52 in the subjects who received a booster immunization with live mumps vaccine was associated with a significantly higher cytotoxic T-lymphocyte response than that of subjects without the gene. Although a donor-dependent difference in the recognition of human leukocyte antigen-A2 suggests the complexity of the genetic mechanisms involved, the results are largely consistent with the concept of major histocompatibility complex-linked genetic control of virus-specific cytotoxic T-lymphocyte response.
D003602:Cytotoxicity, Immunologic; D006680:HLA Antigens / Q000235:genetics*; D015235:HLA-B Antigens; D006801:Humans; D007117:Immunization, Secondary; D008285:Major Histocompatibility Complex; D009109:Mumps virus / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D006680:HLA Antigens; D015235:HLA-B Antigens