Experimental study of the mechanism of autoantibody formation.
A series of experiments on 78 albino mice demonstrated that cultivation in the presence of tuberculin of spleen cells of animals sensitized by BCG vaccine results in an increase of the number of cells producing antibodies to autologous, isologous and heterologous erythrocytes. This also applies to the cultivation of bone marrow cells. Thymus cells neutralize the stimulation of bone marrow cells. The conclusion has been drawn that autoantibodies are synthesized by B-lymphocytes stimulated during the specific immune reaction to microbial antigens. This process is controlled by the thymus whose cells have a suppressive effect on the synthesis of autoantibodies.
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D001402:B-Lymphocytes / Q000276:immunology*; D001500:BCG Vaccine; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D012756:Sheep / Q000097:blood; D013601:T-Lymphocytes / Q000276:immunology*; D014373:Tuberculin / Q000276:immunology*; D014611:Vaccination
D001323:Autoantibodies; D001500:BCG Vaccine; D014373:Tuberculin