[Synthesis and pharmacological activity of amino- and dialkylaminoalkamides of derivatives of 3-carboxy-4-phenylisoquinoline. I].
The synthesis of a series of 1-amino derivatives of 3-carboxymethyl-4-phenylisoquinoline and of dialkylaminoalkylamides of 2-methyl-3-carboxy-4-phenyl-1,2-dihydro-1-oxoisoquinoline and of 1-methoxy-3-carboxy-4-phenylisoquinoline is described. The pharmacological activity of some of these compounds was studied. 1-Morpholino-3-carboxymethyl-4-phenylisoquinoline (IV a) and 1-pyrrolidino derivatives (IV d) caused reduction in spontaneous activity and reactivity in mice whereas compounds (VIII a) and (XII b) showed good local anesthetic activity in infiltration tests.
D000777:Anesthetics / Q000138:chemical synthesis; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects
D000777:Anesthetics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007546:Isoquinolines
Sintesti ed attività farmacologica di ammino- e dialchilamminoalchilammidi-di derivati della 3-carbossi-4-finilisochinolina. Nota I.