Chromosome 14q+ in adult T-cell leukemia.
Cytogenetic studies were performed on leukemic cells from two patients with adult T-cell leukemia. A 14q+ marker chromosome was found in the peripheral blood leukocytes from patient No. 1 and in a leukemic T-cell line (MT-1) derived from the peripheral blood of patient No. 2. The 14q+ resulted from a t(12;14) in patient No. 1 and from a t(Y;14) in patient No. 2 with a break point at 14q32 in each case. In addition, the leukemic cells from patient No. 1 showed a t(1;7) and a 9q-, while the MT-1 line had numerous structural abnormalities. Thus, it is clear that a 14q+ translocation is not restricted to B-cell neoplasms but occurs in T-cell neoplasms as well.
D000328:Adult; D000368:Aged; D002901:Chromosomes, Human, 13-15; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008223:Lymphoma / Q000235:genetics* / Q000473:pathology; D008297:Male; D013601:T-Lymphocytes / Q000473:pathology; D014178:Translocation, Genetic; D014998:Y Chromosome
D005819:Genetic Markers