Modulation of concanavalin A-induced lymphocyte stimulation by human low-density lipoproteins.
Spleen lymphocytes and T cells were stimulated by concanavalin A in the presence of various concentrations of human low-density lipoproteins (LDL). The proliferative responses were measured by [14C]thymidine incorporation. Low LDL doses (5-50 microgram/ml) significantly enhanced the stimulation of splenic lymphocytes and T cells. Further, LDL had the capacity to partially relieve the suppression produced by supraoptimal doses of concanavalin A.
D000818:Animals; D001402:B-Lymphocytes; D002469:Cell Separation; D003208:Concanavalin A / Q000494:pharmacology*; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000494:pharmacology*; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes
D008077:Lipoproteins, LDL; D003208:Concanavalin A