Immune responsiveness of SM/J mice: hyper NK cell activity mediated by NK 1+ Qa 5- cells.
Compared with other inbred strains, SM/J mice have both abnormally high responses to B cell mitogens and hyper NK cell and K cell activity. This hyper NK cell activity is evident even in older SM/J animals, and a high proportion of SM/J nylon-nonadherent lymphocytes that bind target cells also have lytic activity. The SM/J NK cells are NK 1+, Qa 5-, but H-2v identical B10.SM congenic mice have normal NK activity and NK 1+, Qa 5+ NK cells. Together these results suggest the elevation of NK cell activity in SM/J mice is due to chronic activation or maintenance of a Qa 5- NK cell subset. The genetic control of B cell responsiveness and NK cell activity was examined in (B6 x SM)F1 x B6 backcross progeny and (A x SM)F2 intercross mice. No correlation between NK levels and mitogen responsiveness was detected. NK levels in SM/J mice appear to be under polygenic, non-H-2 gene control.
D000818:Animals; D000941:Antigens; D001402:B-Lymphocytes / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D007111:Immunity, Cellular; D007694:Killer Cells, Natural / Q000276:immunology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008934:Mitogens / Q000235:genetics / Q000494:pharmacology*; D010641:Phenotype
D000941:Antigens; D008070:Lipopolysaccharides; D008934:Mitogens