title: Canine prostatic secretions kill Trichomonas vaginalis.
abstract: The zinc content of prostatic secretions is thought to be an important nonspecific defense against urinary tract infection in men. This investigation measured killing by prostatic fluid of Trichomonas vaginalis, a common sexually transmitted pathogen, and related this activity to zinc concentration. We used a canine model which closely resembles the human male genital tract. Prostatic secretions from all dogs killed all T. vaginalis isolates. There appear to be several mechanisms for killing of trichomonads by prostatic fluid. At prostatic fluid zinc concentrations comparable to those in normal men (greater than or equal to 3.2 mM), the rate of killing of trichomonads was proportional to the zinc concentration. At intermediate zinc levels, killing occurred by both zinc-dependent and zinc-independent mechanisms. A zinc-independent mechanism was responsible for antitrichomonal activity at relatively low zinc levels (less than 1.6 mM), comparable to those in the prostatic fluid of men with chronic prostatitis. This study suggests that the variable clinical spectrum of trichomoniasis in men may result from a balance between the zinc sensitivity of the T. vaginalis strains on one side and the content of both zinc and zinc-independent factors in prostatic fluid on the other.
mesh_terms: D000818:Animals; D001826:Body Fluids / Q000032:analysis / Q000502:physiology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D008297:Male; D011467:Prostate / Q000378:metabolism*; D014246:Trichomonas vaginalis / Q000254:growth & development*; D015032:Zinc / Q000032:analysis / Q000494:pharmacology
chemical_list: D015032:Zinc