Alveolar response to experimental Pneumocystis carinii pneumonia in the rat.
In order to characterize the alveolar response to Pneumocystis carinii pneumonia, light and electron miscropy were used to trace the development of experimental infections with P carinii in rats treated with cortisone acetate and a low-protein diet. The first changes were found by the eighth day of treatment and consisted of the selective attachment of Pneumocystis organisms, mostly trophozoites, to alveolar Type 1 pneumocytes; the host cells were undamaged, and no inflammatory response was seen. After approximately one month of treatment, the seemingly innocuous host-parasite interaction was succeeded by focal necrosis of the Type 1 pneumocytes adjacent to organisms; hyperplasia of nearby Type 2 pneumocytes also occurred, to replace the dead Type 1 pneumocytes. Even at this stage, inflammatory reaction was conspicuously absent except for occasional alveolar macrophages in the diseased alveoli; in addition, all cells of the alveolar-capillary membrane other than Type 1 pneumocytes appeared entirely normal. Not only does the present study clarify the nature of alveolar injury caused by Pneumocystis carinii, but it also provides an experimental animal model in which selective injury of the alveolar lining cells occurs.
D000818:Animals; D003348:Cortisone / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D006790:Host-Parasite Interactions; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D011020:Pneumonia, Pneumocystis / Q000276:immunology / Q000473:pathology*; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000382:microbiology / Q000648:ultrastructure*; D051381:Rats
D003348:Cortisone