Immunological aspects of psoriasis. IV. Presence of circulating immune complexes in patients before and after PUVA therapy; correlations with T-cell markers.
We investigated sixteen patients before and after 1 month of PUVA therapy (three times a week) for circulating immune complexes (CIC) and T-cell markers. CIC were detected by the PEG-C4 assay, using a laser nephelometry determination of polyethylene glycol (PEG, 3.5%) precipitated endogenous C4. T cells were evaluated by E rosettes, active E rosettes, anti-HTLA serum and ox EA gamma-rosettes. This latter method investigated mainly T cells bearing Fc receptors for IgG (Tgamma-cells). After 1 month of PUVA-therapy: (a) the cutaneous lesions markedly improved; (b) the mean percentages of E rosettes, active E rosettes, and HTLA bearing cells, depressed before treatment, returned to normal; (c) CIC were found in higher amounts; (d) T gamma-cell numbers decreased simultaneously. The improvement of T-cell levels assessed by E rosettes, active E rosettes and HTLA values was correlated with clearing of skin lesions, as previously reported by others. However, the increase of CIC during PUVA therapy, their correlation with T gamma-cell decrease, and their possible role in the pathogenic chain of psoriasis remains uncertain.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex; D003181:Complement C4 / Q000032:analysis; D005260:Female; D011564:Furocoumarins / Q000627:therapeutic use*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D011565:Psoriasis / Q000188:drug therapy / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D000936:Antigen-Antibody Complex; D003181:Complement C4; D011564:Furocoumarins