Tolciclate versus miconazole, a double-blind trial in patients with dermatomycosis.
Eighty-one patients with dermatomycosis such as tinea corporis, tinea cruris, tinea pedis and pityriasis versicolor were treated with tolciclate 1% cream or miconazole 2% cream. Parasitological cure was obtained in 100% of the patients given tolciclate and in 97.4% of those given miconazole. Patients and investigator considered tolciclate treatment as excellent, respectively, in 76.2% and 73.8% of the cases. The corresponding figures for miconazole were 74.4% and 66.7%. Both treatments were well tolerated.
D000287:Administration, Topical; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003881:Dermatomycoses / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D008825:Miconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D010043:Outcome and Process Assessment, Health Care; D010915:Pityriasis / Q000188:drug therapy; D013859:Thiocarbamates / Q000627:therapeutic use*; D014005:Tinea / Q000188:drug therapy; D014008:Tinea Pedis / Q000188:drug therapy
D000935:Antifungal Agents; D007093:Imidazoles; D013859:Thiocarbamates; D008825:Miconazole; C013305:tolciclate