title: Allotype suppression in the chicken. II. Suppression in homozygous chickens with antiallotype antibody and allotype-disparate B cells.
abstract: Injection of heterozygous (M-1a/M-1b, G1g/G-1i) B 14-line chickens with antisera directed against either IgM-1a or IgM-1b induced suppression of the relevant IgM-1 and genetically linked IgG-1 allotypes, whereas a mixture of anti-M-1a and anti-M-1b antibodies failed to produce allotype suppression. Injection of anti-M-1 antiserum into M-1 homozygous chickens induced only a transient delay of a few days in the appearance and rise of serum IgM-1 levels. However, suppression of host allotypes was induced by injecting M-1, G-1 homozygous neonatal or embryonal recipients with anti-M-1 antisera together with B locus- histocompatible allotype-disparate spleen, bone marrow or bursal cells. The active cell type were donor B cells, which established chimerism in the injected host, whereas peripheral blood T lymphocytes from agammaglobulinemic donors were ineffective. Allotype suppression was attributed to a homeostatic control mechanism which is exerted by normal B cells (but not T cells) over B cell recruitment in anti-M-1 antibody-treated, immature hosts.
mesh_terms: D000818:Animals; D000906:Antibodies; D000888:Antibodies, Anti-Idiotypic; D001402:B-Lymphocytes / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology; D002060:Bursa of Fabricius / Q000276:immunology; D002645:Chickens; D006579:Heterozygote; D006720:Homozygote; D007106:Immune Sera / Q000494:pharmacology; D007126:Immunoglobulin Allotypes / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology; D007165:Immunosuppression Therapy; D007700:Kinetics; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000906:Antibodies; D000888:Antibodies, Anti-Idiotypic; D007106:Immune Sera; D007126:Immunoglobulin Allotypes; D007075:Immunoglobulin M