title: The induction of chromosome aberrations in human lymphocytes by alpha-radiation.
abstract: Human blood has been irradiated with alpha-particles from an external source of curium-242. The collimated alpha-particles entered the blood with an energy of 4-9 MeV and were almost completely absorbed by the blood. After culturing for 48 hours, the dicentric yield in the lymphocytes at the first metaphase was measured as a function of dose to the blood. The yield was linear with dose up to 400 rad with a slope of 28x6 X 10(4) dicentrics/cell per rad. This is equivalent to an initial slope r.b.e. of 17x9 with respect to cobalt-60 gamma-rays. This value disagrees with the only two other published values in the literature. Reasons for this disagreement are discussed. Compared with neutron r.b.e values obtained in this laboratory the alpha-particle values we observe are surprisingly low. A model is proposed which predicts low values of r.b.e. for chromosome aberration production using radiations of high LET. The low values occur because there is a distribution of specific energy between cells which causes a selective removal of cells likely to contain higher numbers of aberrations.
mesh_terms: D000512:Alpha Particles; D002470:Cell Survival; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004307:Dose-Response Relationship, Radiation; D004735:Energy Transfer / Q000528:radiation effects; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008954:Models, Biological