Combined tinidazole and doxycycline prophylaxis in colorectal surgery. An interhospital trial.
There were no significant differences between randomized groups on either preoperative tinidazole or placebo added to pre-, per, and postoperative doxycycline. Cases of anaerobic infection among the placebos patients as well as a general trend of the parameters studied suggest that tinidazole gives added protection, i.e. that antibiotic prophylaxis should also comprise anaerobic microbes.
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003106:Colon / Q000601:surgery*; D004318:Doxycycline / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009593:Nitroimidazoles / Q000627:therapeutic use*; D010919:Placebos; D011182:Postoperative Care; D011292:Premedication; D011897:Random Allocation; D012007:Rectum / Q000601:surgery*; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014011:Tinidazole / Q000627:therapeutic use*
D009593:Nitroimidazoles; D010919:Placebos; D014011:Tinidazole; D004318:Doxycycline