[Action of the antitumor antibiotics, rubomycin and carminomycin, on the T- and B-cell population ratio in mouse lymphoid organs].
Quantitative ratios of T- and B-cells in the lymphoid organs of mice were studied comparatively at various periods after administration of rubomycin and carminomycin in maximum tolerated doses, i. e. 20 and 3 mg/kg. It was found that the antibiotics decreased the total number of the cariocytes in these organs and induced irregular elimination of T- and B-cells from the spleen and lymph nodes. Comparison of the time-course of T- and B-lymphocyte population reduction suggested that the cells reduced independently of each other, the reduction rate of B-cells being higher than that of T-cells.
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects*; D002360:Carubicin / Q000494:pharmacology*; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007958:Leukocyte Count; D008221:Lymphoid Tissue / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000187:drug effects*; D013997:Time Factors
D002360:Carubicin; D003630:Daunorubicin
Deĭstvie protvioopukholevykh antibiotikov rubomitsina i karminomitsina na sootnorshenie populiatsiĭ T- i B-kletok v limfoidnykh organakh mysheĭ.