Recovery from intravenous anaesthesia. Comparison of disoprofol with thiopentone and methohexitone.
Using the endpoints of spontaneous opening of eyes, giving date of birth, sitting up unaided and normal pegboard time, recovery from 2 and 3 mg/kg disoprofol was compared with that from 4 and 6 mg/kg thiopentone and 1.5 mg/kg methohexitone in groups each of 10 unpremedicated patients. The study method differentiated between recovery from the two doses of disoprofol and thiopentone at the first two endpoints only. A between-drug comparison showed early recovery was slightly faster with thiopentone than with equivalent doses of the new drug while no differences were detected between the recovery from equivalent doses of methohexitone and thiopentone. The differences found in this study are felt to be of no clinical significance and recovery from anaesthesia with disoprofol would not be expected to be any slower than that from equivalent doses of thiopentone.
D000328:Adult; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000494:pharmacology; D001143:Arousal / Q000187:drug effects; D005260:Female; D006801:Humans; D008723:Methohexital / Q000494:pharmacology; D010636:Phenols / Q000494:pharmacology; D015742:Propofol; D013874:Thiopental / Q000494:pharmacology; D013997:Time Factors
D000777:Anesthetics; D010636:Phenols; D008723:Methohexital; D013874:Thiopental; D015742:Propofol