The effect of adriamycin on repair of sublethal damage and slow repair in irradiated mouse lung.
The interaction of Adriamycin with radiation damage in the mouse lung has been shown to disappear with the same kinetics as those for the 'slow repair' of such radiation damage. Split-dose experiments have demonstrated that Adriamycin inhibits this 'slow-repair' process whereas the drug has no effect on the repair of sublethal damage in irradiated mouse lung.
D000818:Animals; D004260:DNA Repair / Q000528:radiation effects*; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008168:Lung / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013997:Time Factors; D014965:X-Rays
D004317:Doxorubicin