Morphogenesis and pathogenesis of chronic lung diseases. XVIII. Influence of cyclophosphamide on the evolution toward fibrosis of experimental lung granulomas: a quantitative analysis.
The stereotyped evolution toward fibrosis of lung granulomas induced in rabbits by an intravenous injection of the complete Freund adjuvant was analysed under the influence of a prolonged treatment with cyclophosphamide. While the histopathological picture of untreated rabbits showed a progressive evolution toward fibrosis of experimental lung granulomas, cyclophosphamide administration (1.5 mg/kg body, daily for three weeks) reduced the number of granuloma cells on the surface unit and the density of reticulin fibrils up to statistically significant values.
D000818:Animals; D002908:Chronic Disease; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005620:Freund's Adjuvant; D006099:Granuloma / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008171:Lung Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D008297:Male; D011658:Pulmonary Fibrosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D011817:Rabbits; D013997:Time Factors
D003520:Cyclophosphamide; D005620:Freund's Adjuvant