title: Epidermal growth factor and proliferation of odontogenic cells in culture.
abstract: The proliferation of bovine odontogenic epithelial (OE) and mesenchymal (OM) cells cultured in the presence of varying concentrations of epidermal growth factor (EGF) was examined. After a delay of two to three d, EGF-supplemented cultures contained significantly more cells than did controls. This effect was dose-dependent, was maximal at 10-9 g EGF/ml for OE and 10-8 g EGF/ml for OM, and was dependent on the presence of serum in the culture medium. The results suggest the possibility that EGF may play a role in the control of odontogenic cell proliferation in vivo.
mesh_terms: D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D009805:Odontogenesis / Q000187:drug effects*; D013997:Time Factors; D014083:Tooth Germ / Q000166:cytology* / Q000187:drug effects
chemical_list: D004815:Epidermal Growth Factor