Different effects of concanavalin A-activated T-cells on the in vitro IgG and IgE biosynthesis in asthmatic children and normals.
The T-cell regulations of IgG and IgE biosynthesis were studied by treating purified T-cells from normal adult and asthmatic patients with various concentrations of concanavalin A (Con A) and the co-cultivated with allogeneic mononuclear cells in the presence of pokeweed mitogen for seven days. After being treated with 20 microgram/ml or more of Con A for 18 hours, T-cells from both normal and allergic individuals were able to suppress IgG, but not IgE, production of allogeneic lymphocytes. The results suggest that the T-cell regulation of IgE production is different from that of IgG synthesis and allergic patients do retain suppressor T-cell function(s).
D000293:Adolescent; D001249:Asthma / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003208:Concanavalin A / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*
D007074:Immunoglobulin G; D003208:Concanavalin A; D007073:Immunoglobulin E