The radiation dosimetry of 2 [F-18]fluoro-2-deoxy-D-glucose in man.
Bladder and brain time-activity measurements in humans were performed after the intravenous administration of 2-[F-18]fluoro-2-deoxy-D-glucose. Radiation doses were calculated using the MIRD schema. The bladder wall received an average of 440 mrad/mCi (s.e. 76) in ten subjects who voided at 2 hr after administration of tracer. If these subjects had voided at 1 hr, the bladder-wall dose would have been reduced to 220 mrad/mCi. The brain received an average of 81 mrad/mCi in eight subjects. The doses to other organs, calculated from published dog biodistribution data, are between 50 and 85 mrad/mCi except for spleen and heart, which both received 160 mrad/mCi. These time-activity measurements for the critical organ in the human avoid the assumptions made in using animal biodistribution data for human dosimetry calculations.
D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism*; D005461:Fluorine / Q000378:metabolism*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008875:Middle Aged; D011829:Radiation Dosage; D011868:Radioisotopes / Q000378:metabolism*; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed; D001743:Urinary Bladder / Q000000981:diagnostic imaging / Q000378:metabolism*
D003837:Deoxy Sugars; D011868:Radioisotopes; D019788:Fluorodeoxyglucose F18; D005461:Fluorine; D003847:Deoxyglucose