Peripheral localisation of an IgE immune response at axillary lymph nodes draining the site of a local parasitic infection.
Wistar-Furth rats were infected subcutaneously with L3 larvae of Dipetalonema viteae, filaria of Meriones libycus. Lymph nodes draining the site of immunization contained numerous IgE-staining cells identified as lymphoid cells. In other lymphoid tissues, IgE-staining cells were rare. They were absent in the lamina propria of the small intestine. These data support the view that IgE lymphoid precursors are present in peripheral lymph nodes.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D001365:Axilla; D004154:Dipetalonema Infections / Q000276:immunology* / Q000469:parasitology; D005368:Filariasis / Q000276:immunology*; D007070:Immunoglobulin A / Q000276:immunology; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology*; D008297:Male; D008407:Mast Cells / Q000276:immunology; D010950:Plasma Cells / Q000276:immunology; D051381:Rats; D011920:Rats, Inbred WF; D011922:Rats, Mutant Strains
D000888:Antibodies, Anti-Idiotypic; D007070:Immunoglobulin A; D007075:Immunoglobulin M; D007073:Immunoglobulin E