IgG immune deposits in glomerular lesions of young New Zealand Black mice.
IgG immune deposits in glomerular lesions were found in 62% of 4-week-old mice born from anti-DNA antibody positive mothers but not in the mice born from anti-DNA antibody negative ones. In the former mice anti-DNA antibody producing cells could not be detected in spite of the presence of antibody. These results indicate that maternal anti-DNA antibody might be responsible for the development of glomerular lesions in the offsprings. Renal lesions, however, was not observed in the 2- to 3-month-old mice indicating that permanent lesions were not induced by this transient maternal antibody.
D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis*; D007678:Kidney Glomerulus / Q000276:immunology*; D051379:Mice; D008814:Mice, Inbred NZB; D013154:Spleen / Q000276:immunology
D000974:Antibodies, Antinuclear; D007074:Immunoglobulin G