[Cytotoxic complement-dependent anti-thrombocyte antibodies in rheumatoid arthritis patients].
Sera of 38 patients and 10 blood donors were examined for cytotoxicity against human thymocytes. As method for testing the complement-dependent cytotoxicity the lymphocytotoxicity test was adapted for thymocytes. The sera of blood donors and of patients with non-rheumatic diseases showed no or only a very small rate of cytolysis (3.6%). The rate of cytolysis of sera of patients with arthroses (8.5%) and of collagenoses (14.5%) were below 20%, i.e. still within the limits of normal. The sera of seronegative arthritides (30%) and of patients with rheumatoid arthritis (40%) showed an unequivocally pathological cytotoxicity. The complement-dependent thymocytotoxicity might be coordinated to the clinical arthritis.
D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D001792:Blood Platelets / Q000276:immunology*; D003095:Collagen Diseases / Q000276:immunology; D003165:Complement System Proteins / Q000032:analysis*; D003602:Cytotoxicity, Immunologic; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology
D001323:Autoantibodies; D003165:Complement System Proteins
Zytotoxische komplementabhängige Anti- Thymozyten-Antikörper bei Rheumatoid-Arthritis-Patienten.