The effects of acetaldehyde and disulfiram on albumin synthesis in the isolated perfused rabbit liver.
Acetaldehyde infusions inhibit albumin synthesis in the liver from fed donors but not in the livers from fasted donors. The inhibition of acetaldehyde metabolism with 4-MP and disulfiram reverses this finding, suggesting that acetaldehyde per se is not the toxic agent. Disulfiram stimulates albumin synthesis in livers from fasted donors, and the presence of acetaldehyde does not prevent this process. The effects of ethanol infusions cannot be explained as due to the presence of acetaldehyde; some intermediate metabolic step may be the basis of the inhibition of albumin production and polysome disaggregation in the presence of ethanol.
D000079:Acetaldehyde / Q000494:pharmacology*; D000418:Albumins / Q000096:biosynthesis*; D000818:Animals; D004247:DNA / Q000378:metabolism; D004221:Disulfiram / Q000494:pharmacology*; D005215:Fasting; D066298:In Vitro Techniques; D007773:Lactates / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011132:Polyribosomes / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D011817:Rabbits; D014508:Urea / Q000378:metabolism
D000418:Albumins; D007773:Lactates; D011773:Pyruvates; D012313:RNA; D014508:Urea; D004247:DNA; D000079:Acetaldehyde; D004221:Disulfiram