Reward and detection thresholds for brain stimulation: dissociative effects of cocaine.
The effects of cocaine on both rewarding and detection thresholds for intracranial stimulation to the same brain sites in the same animals were determined. The drug caused a dissociation in effects on the two types of brain stimulation. Detection threshold was elevated at doses of cocaine that lowered the reward threshold.
D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D008297:Male; D008474:Medial Forebrain Bundle / Q000187:drug effects; D009042:Motivation / Q000187:drug effects*; D051381:Rats; D012653:Self Stimulation / Q000187:drug effects*; D012684:Sensory Thresholds
D003042:Cocaine