Effects of norepinephrine and 5-hydroxytryptamine reuptake inhibitors on electrically-induced spinal cord seizures in rats.
Nisoxetine and desipramine (inhibitors of norepinephrine reuptake) each exerted a suppressant effect on spinal cord seizures by decreasing the duration of tonic extension. In addition, desipramine increased the duration of tonic flexion and nisoxetine decreased the total duration of seizure. In contrast, citalopram (an inhibitor of 5-hydroxytryptamine reuptake) did not affect any of these seizure components. These observations support the concept that spinal cord noradrenergic, but not 5-hydroxytryptaminergic neurons act as attenuators of convulsive activity.
D000818:Animals; D001572:Benzofurans / Q000494:pharmacology; D015283:Citalopram; D003891:Desipramine / Q000494:pharmacology; D004558:Electric Stimulation; D005260:Female; D005473:Fluoxetine / Q000031:analogs & derivatives / Q000494:pharmacology; D009638:Norepinephrine / Q000037:antagonists & inhibitors*; D011437:Propylamines / Q000494:pharmacology; D051381:Rats; D012640:Seizures / Q000517:prevention & control*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013116:Spinal Cord / Q000502:physiology*
D001572:Benzofurans; D011437:Propylamines; D012702:Serotonin Antagonists; D005473:Fluoxetine; D015283:Citalopram; C011386:nisoxetine; D003891:Desipramine; D009638:Norepinephrine