The immotile cilia syndrome: explanation for many a clinical mystery.
With the advent of electron microscopy, ciliary abnormalities could be detected, analyzed, and correlated with clinical problems. Kartagener's syndrome, identified over 40 years ago as a triad of sinusitis, bronchiectasis, and situs inversus, was found to actually be a subset of a broader category of diseases: the immotile cilia syndrome. Two other subsets involving multiple organ systems have also been recognized.
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D001980:Bronchi / Q000473:pathology; D001982:Bronchial Diseases / Q000473:pathology; D002648:Child; D002923:Cilia / Q000473:pathology* / Q000502:physiology / Q000648:ultrastructure; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis; D007619:Kartagener Syndrome / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008854:Microscopy, Electron; D009068:Movement; D009297:Nasal Mucosa / Q000473:pathology / Q000648:ultrastructure; D012141:Respiratory Tract Infections / Q000473:pathology; D013577:Syndrome