Corticosteroids in acute myocardial infarction.
Forty-two patients admitted to the Coronary Care Unit with a diagnosis of acute myocardial infarction were studied within 24 hours of the onset of symptoms. In addition to therapy determined by the attending physician, there was a double-blinded administration of either a placebo or methylprednisolone, 30 mg/kg intravenously every 6 hours for four doses. This drug had no beneficial effect on infarct size, dysrhythmias, complications, or left ventricular function 2 weeks after infarction.
D003402:Creatine Kinase / Q000097:blood; D004452:Echocardiography; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000150:complications; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy*; D010919:Placebos; D013599:Systole; D013610:Tachycardia / Q000150:complications; D014693:Ventricular Fibrillation / Q000150:complications
D007527:Isoenzymes; D010919:Placebos; D003402:Creatine Kinase; D008775:Methylprednisolone