Combined vitamin D parathyroid defect in thalassemia major.
A 17-year-old girl with thalassemia major experienced tetany. The serum calcium level was 5.5 mg/dL, and the phosphorus level was 6.3 mg/dL. Serum levels of parathyroid hormone (PTH) and 25-hydroxyvitamin D (25-OHD) were subnormal at 125 pg/mL and 8.1 ng/mL, respectively, As a result of these findings, serum 25-OHD and PTH levels were measured in an additional 12 patients with thalassemia major. Low levels of both 25-OHD and PTH were found frequently. An increase in serum 25-OHD levels was noted in each of four patients who were examined after iron chelation therapy.
D015652:25-Hydroxyvitamin D 2; D000293:Adolescent; D000328:Adult; D002648:Child; D003676:Deferoxamine / Q000627:therapeutic use; D004872:Ergocalciferols / Q000031:analogs & derivatives* / Q000097:blood / Q000172:deficiency; D005260:Female; D006801:Humans; D007011:Hypoparathyroidism / Q000150:complications*; D008297:Male; D013789:Thalassemia / Q000097:blood / Q000150:complications*
D004872:Ergocalciferols; D015652:25-Hydroxyvitamin D 2; D003676:Deferoxamine