E receptor expression of T lymphocytes in T lymphoproliferative diseases.
The lymphoid component of skin infiltrates from 6 cases of mycosis fungoides and 2 cases of T cell chronic lymphatic leukaemia consisted almost exclusively of T lymphocytes with abnormally high E receptor expression. Such T cells were also found to dominate the skin infiltrates from 10 patients with severe atopic dermatitis. Blood T lymphocyte counts from all types of patients were within the normal range, but even the blood T lymphocytes of the patients had a strong E receptor expression. The bone marrow in atopic dermatitis and in mycosis fungoides showed normal T cell counts with normal E receptor expression. Supported by basic lymphocyte-kinetic considerations it is likely that the skin in T lymphoproliferative diseases is characterized by an abnormal ability to home and/or to trap T lymphocytes with strong E receptor expression.
D000328:Adult; D000368:Aged; D000818:Animals; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D003876:Dermatitis, Atopic / Q000276:immunology; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology; D008232:Lymphoproliferative Disorders / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000276:immunology; D011948:Receptors, Antigen, T-Cell; D012397:Rosette Formation; D012756:Sheep; D013601:T-Lymphocytes / Q000276:immunology
D011948:Receptors, Antigen, T-Cell