Phytohaemagglutinin (PHA)-induced transformation of peripheral blood-lymphocytes in leprosy patients.
101 patients belonging to different types of leprosy were investigated for PHA-induced lymphocyte transformation in peripheral blood. There was a significant depression (P < 0.05) in blastogenesis in borderline (BB), borderline lepromatous (BL) and lepromatous (LL) patients. On the other hand, tuberculoid (TT) and borderline tuberculoid (BT) patients did not show any alteration in PHA-induced blastogenesis (P > 0.05) when compared to normal. The significance of these findings have been discussed.
D003622:Dapsone / Q000627:therapeutic use; D006801:Humans; D007918:Leprosy / Q000188:drug therapy / Q000276:immunology*; D008213:Lymphocyte Activation; D010835:Phytohemagglutinins / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology
D010835:Phytohemagglutinins; D003622:Dapsone