Thymocyte stimulating activity of the serum of rats in the early phase after 2-acetylaminofluorene (AAF)-treatment.
The serum of rats collected at various time intervals after application of a single dose of 2-acetylaminofluorene (AAF) stimulates the incorporation of 3H-thymidine into the DNA of cultured thymocytes of rats, mice and hamsters. This reaction shows a clear dose-response relationship. The serum activity is dialysable and relatively thermostable.
D015073:2-Acetylaminofluorene / Q000494:pharmacology*; D000818:Animals; D006224:Cricetinae; D004247:DNA / Q000096:biosynthesis; D006498:Hepatectomy; D008297:Male; D051381:Rats; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism
D004247:DNA; D015073:2-Acetylaminofluorene; D013936:Thymidine