Cytotoxic T lymphocyte lines (CTLL) against a human minor alloantigen.
Cytotoxic T-cell lines were generated following in vitro culture of lymphocytes from a patient suffering from aplastic anemia together with those of his HLA-identical brother, a repeated transfusion donor. The segregation pattern within the family of the determinant(s) detected by these cytotoxic cells strongly suggested that a minor alloantigen(s) was being detected. Testing of the effectors on a panel of unrelated individuals indicated that it was best seen in association with HLA-B7, which was common to both the patient and his sibling donor.
D000741:Anemia, Aplastic / Q000235:genetics / Q000276:immunology / Q000628:therapy; D001803:Blood Transfusion; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D007519:Isoantigens / Q000276:immunology*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*
D006680:HLA Antigens; D007519:Isoantigens