Peripheral rosette forming cells with SRBC-AET in type B acute viral hepatitis.
Peripheral E-rosette forming cells (E-RFC) have been enumerated in 15 patients with type B acute viral hepatitis (AVH-B) using sheep red blood cells pretreated with 2-aminoethylisothiouronium bromide (SRBCAET). Percentages of E-RFC in mononuclear cells (MC) preparations obtained during the acute stage of the disease were not different from those in normal controls. Patients re-assayed in the resolving period of AVH-B universally showed significantly reduced values of E-RFC compared to the acute phase values. Defective rosetting with SRBCAET may reflect immune-related modifications associated with the recovery from hepatitis B virus infection.
D000818:Animals; D004912:Erythrocytes; D006509:Hepatitis B / Q000276:immunology*; D012397:Rosette Formation; D012756:Sheep; D013601:T-Lymphocytes / Q000276:immunology*; D000338:beta-Aminoethyl Isothiourea / Q000494:pharmacology*
D000338:beta-Aminoethyl Isothiourea