Xenogeneic cellular immune responses and the control of microscopic tumor. A model.
Regimens for the generation of a highly cytotoxic xenogeneic response, the mechanism of this response, and its effect on tumor cells were investigated in a rat antimouse tumor system. Fischer 344 rats were immunized with EL-4 lymphoma and the ability of the sensitized rat lymphocytes to suppress the local growth of four different C57BL/6 tumors was evaluated. Optimal sensitization of the rat was achieved using large numbers of viable tumor cells in a primary intraperitoneal immunization. Highly cytotoxic effector cells generated in this xenogeneic setting significantly suppressed the local growth of appropriate tumor targets. Rat T cells appeared to be the sole effector cell and their effect was abrogated by anti-rat immune responses in the host mouse. This rat anti-EL-4 model with allow further investigation into xenogeneic antitumor responses and their possible role in local immunotherapy.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D007111:Immunity, Cellular; D007114:Immunization; D007165:Immunosuppression Therapy; D008223:Lymphoma / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000276:immunology*; D051381:Rats; D011916:Rats, Inbred F344; D013601:T-Lymphocytes / Q000276:immunology
D000951:Antigens, Neoplasm