Total lymphoid irradiation and cyclophosphamide as preparation for bone marrow transplantation in severe aplastic anemia.
A new combination of total lymphoid irradiation and cyclophosphamide was used prior to bone marrow transplantation in an attempt to achieve decreased rejection rates and graft-versus-host disease. Nine previously transfused patients with severe aplastic anemia received marrow from an HLA-identical, MLC-compatible sibling following this preparative regimen. There were no episodes of graft rejection, and only one patient developed graft-versus-host disease. Of the 9 patients, 7 (78%) are surviving with a median follow-up of 400 days. The excellent results of this pretransplant combination of total lymphoid irradiation and cyclophosphamide warrants application of this regimen to a larger series of patients.
D000293:Adolescent; D000741:Anemia, Aplastic / Q000401:mortality / Q000532:radiotherapy*; D016026:Bone Marrow Transplantation; D002177:Candidiasis / Q000150:complications; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000627:therapeutic use*; D006084:Graft Rejection; D006087:Graft vs Host Reaction; D006801:Humans; D007165:Immunosuppression Therapy; D007223:Infant; D008221:Lymphoid Tissue / Q000378:metabolism / Q000528:radiation effects*; D018805:Sepsis / Q000150:complications; D014184:Transplantation, Homologous; D014965:X-Rays
D003520:Cyclophosphamide