[Double-stranded DNA antibodies in discoid lupus erythematosus].
Antibodies to double stranded ds DNA were comparatively studied in the sera of untreated DLE patients and in the sera of the same persons after one month's chloroquine administration by a modified ELISA technique. Antibodies were found in both IgG and IgM classes. Untreated DLE patients showed a significantly higher antibody level than the healthy controls. During the chloroquine administration, the level of antibodies decreased first in the IgG class.
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D002738:Chloroquine / Q000627:therapeutic use; D004247:DNA / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008179:Lupus Erythematosus, Discoid / Q000188:drug therapy / Q000276:immunology*; D008297:Male
D000974:Antibodies, Antinuclear; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D002738:Chloroquine; D004247:DNA
Doppelstrangige DNS-Antikörper bei discoidem Lupus erythematodes (DLE).