Fatal veno-occlusive disease of the liver following high dose chemotherapy, irradiation and bone marrow transplantation.
In two patients fatal veno-occlusive disease of the liver developed after bone marrow transplantation for underlying malignancies. Both had received significant pretransplant chemotherapy, including cystosine arabinoside, and total body irradiation. The diagnosis of veno-occlusive disease should be considered in patients in whom hepatomegaly, ascites and deteriorating liver function tests develop after they have received cancer chemotherapy.
D000970:Antineoplastic Agents / Q000009:adverse effects*; D016026:Bone Marrow Transplantation; D002051:Burkitt Lymphoma / Q000628:therapy; D002648:Child; D003561:Cytarabine / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D006503:Hepatic Veins; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008099:Liver / Q000098:blood supply; D008107:Liver Diseases / Q000209:etiology*; D008297:Male; D011878:Radiotherapy / Q000009:adverse effects*; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014652:Vascular Diseases / Q000209:etiology
D000970:Antineoplastic Agents; D003561:Cytarabine