title: Halothane and morphine-nitrous oxide anesthesia in patients undergoing coronary artery bypass operation. Patterns of intraoperative ischemia.
abstract: To examine whether the hemodynamic responses to halothane or morphine-nitrous oxide anesthesia produce different patterns of myocardial ischemia in patients undergoing myocardial revascularization, we studied 26 patients anesthetized with nitrous oxide (50%) and either halothane (0.2% to 1.0% end-tidal concentration) or morphine (2 mg/kg, given intravenously). We measured systemic and coronary hemodynamics and took blood samples to measure blood gases, oxygen content, and lactate and norepinephrine concentrations. Systemic blood pressure, rate-pressure produce, systemic vascular resistance, cardiac output, and stroke work were elevated following sternotomy in patients anesthetized with morphine, whereas halothane obtunded these hemodynamic responses to surgical stress. Intraoperative myocardial ischemia occurred in both patient groups. Ten of 14 patients receiving halothane and eight of 12 receiving morphine had at least one episode of either ST-segment depression or myocardial lactate production. The difference between these groups was not statistically significant. Only patients anesthetized with morphine had a significantly elevated rate-pressure product when ischemia occurred. In this selected series of patients subjected to myocardial revascularization, two sustained a myocardial infarction and four died in the postoperative period. The incidence of these and other indices of postoperative morbidity was not related to choice of primary anesthetic and did not differ between the patients who sustained ischemia and those who did not.
mesh_terms: D000768:Anesthesia, General / Q000009:adverse effects*; D001026:Coronary Artery Bypass; D003326:Coronary Circulation / Q000187:drug effects*; D006221:Halothane / Q000009:adverse effects*; D006321:Heart / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007431:Intraoperative Complications; D009020:Morphine / Q000009:adverse effects*; D009206:Myocardium / Q000378:metabolism; D009609:Nitrous Oxide / Q000009:adverse effects*; D010101:Oxygen Consumption / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D009020:Morphine; D009609:Nitrous Oxide; D006221:Halothane