Regional cerebral blod flow studied by xenon-133. Intra-arterial injection studies and inhalation studies using emission tomography.
A survey of the Xenon-133 techniques for measurement of regional cerebral blood flow, rCBF, in man is presented. The intra-arterial Xe-133 injection method is very sensitive for detecting even small hyperemic areas, but cannot "see" smaller ischemic areas. The Xe-133 inhalation (or i.v. inj.) technique is insensitive both to hyperemia and ischemia yielding essentially only a mean flow value. A new rapidly moving single photon tomograph following D. Kuhl's principle is presented applicable to Xe-133. Preliminary clinical data show that this technique is able to detect ischemic areas both with Xe-133 intra-arterial injection and with Xe-133 inhalation. The practical and economic advantages of Xe-133 or Xe-127 tomography over positron tomography for rCBF are discussed.
D000281:Administration, Intranasal; D002545:Brain Ischemia / Q000000981:diagnostic imaging; D002536:Cerebral Arteries / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D006801:Humans; D006940:Hyperemia / Q000000981:diagnostic imaging; D007269:Injections, Intra-Arterial; D014055:Tomography, Emission-Computed / Q000379:methods*; D014980:Xenon Radioisotopes / Q000008:administration & dosage
D014980:Xenon Radioisotopes