title: [Berger's disease. Study of eleven cases (author's transl)].
abstract: Among 39 patients with recurrent hematuria, 11 accomplished criteria of Berger's disease. The frequent association between recurrent hematuria and upper respiratory tract infections as well as constant elevation of serum IgA are emphasized. Their finding as well as the deposition of IgA on the mesangium and C'3 without C1q and C'4 suggest an alternative activation of the complement system which could explain the role of the IgA in the pathogenesis of Berger's disease. The disease can begin as acute glomerulonephritis and occasionally as a nephrotic syndrome, and its' prognosis is generally good in most instances.
mesh_terms: D002648:Child; D002675:Child, Preschool; D003166:Complement Activating Enzymes / Q000032:analysis; D015922:Complement C1q; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003170:Complement Pathway, Alternative; D003165:Complement System Proteins / Q000032:analysis*; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000276:immunology*; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D008297:Male; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000150:complications
chemical_list: D003176:Complement C3; D003181:Complement C4; D007070:Immunoglobulin A; D015922:Complement C1q; D003165:Complement System Proteins; D003166:Complement Activating Enzymes
vernacular_title: Enfermedad de Berger. Estudio de 11 casos.