Preliminary experience with ICI 35 868 as an i.v. induction agent: comparison with althesin.
In a small open dose-finding study the i.v. dose of ICI 35 868 required to induce anaesthesia in healthy adults was 2 mg kg-1. Comparison of this dose with Althesin 0.05 ml kg-1 for i.v. induction, both injected over 30 s suggests that they have similar effects on heart rate, arterial pressure and breathing. The mean times to loss of eyelash reflex were 57 +/- SD 10.1 s (ICI 35 868) and 46 +/- 3.9s (Althesin). The new drug was associated with pain and discomfort on injection in seven of 10 patients, but with less involuntary movement than occurred with Althesin.
D000293:Adolescent; D000328:Adult; D000530:Alfaxalone Alfadolone Mixture / Q000008:administration & dosage / Q000494:pharmacology; D000771:Anesthesia, Intravenous / Q000379:methods*; D000777:Anesthetics / Q000008:administration & dosage / Q000494:pharmacology; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D010636:Phenols / Q000008:administration & dosage / Q000494:pharmacology; D015742:Propofol
D000777:Anesthetics; D010636:Phenols; D000530:Alfaxalone Alfadolone Mixture; D015742:Propofol