Anti-inflammatory action of dexamethasone in vitrectomy infusion fluid.
Vitrectomy and lensectomy were performed in rabbits with infusion fluid containing dexamethasone. No ocular toxicity was observed in eyes that received dexamethasone up to a concentration of 400 micrograms/ml. Utilizing sensitive radioimmunoassay techniques after surgery, we observed significant reduction in ocular albumin levels in eyes treated with dexamethasone when compared with control eyes in which dexamethasone was not used. However, there was no significant difference in immunoglobulin levels between eyes from both groups.
D000418:Albumins / Q000032:analysis; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use*; D009877:Endophthalmitis / Q000517:prevention & control*; D005123:Eye / Q000032:analysis / Q000187:drug effects; D005136:Eye Proteins / Q000032:analysis; D007908:Lens, Crystalline / Q000601:surgery; D011817:Rabbits; D014822:Vitreous Body / Q000601:surgery*
D000418:Albumins; D005136:Eye Proteins; D003907:Dexamethasone