[Probable nature of a cell population facilitating splenic colony formation].
It has been disclosed that only syngeneic thymocytes are capable of stimulating colony-formation by the bone marrow treated with rabbit anti-mouse brain serum (RAMBS). The treatment of syngenic thymocytes with anti-theta-serum produces a negligible lowering of this effect. Meanwhile the treatment of the donor thymus with Con A 48 hours before the collection of thymocytes completely abolished the ability of these cells to stimulate colony-formation. The evidence suggests that the bone marrow may include a cell population with surface antigens reacting with RAMBS but not with anti-theta-serum which functions as a trigger in relation to CFUs. These cells seem likely to be precursors of T lymphocytes.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001921:Brain / Q000276:immunology; D003114:Colony-Forming Units Assay; D006824:Hybridization, Genetic; D007106:Immune Sera / Q000494:pharmacology; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D014185:Transplantation, Isogeneic
D000961:Antilymphocyte Serum; D007106:Immune Sera
Veroiatnaia priroda kletochnoĭ populiatsii, sposobstvuiushcheĭ selezenochnomu kolonieobrazovaniiu.