title: Diastereomeric 7-alpha-ureidoacetyl cephalosporins. V. Antimicrobial activity, beta-lactamase stability and pharmacokinetics of 7-(alpha-ureido-2-amino-4-thiazolylacetyl)-cephalosporins.
abstract: Diastereomeric 7-(alpha-ureido-2-amino-4-thiazolylacetyl)cephalosporins are broad-spectrum antimicrobial agents with activity mainly against Gram-negative bacteria. The L-isomers were more potent than the D-isomers. All compounds showed some degree of stability to beta-lactamases. The compounds reached high serum and tissue fluid levels and were excreted unchanged mainly in urine.
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D002510:Cephalosporinase / Q000378:metabolism*; D002511:Cephalosporins / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D004355:Drug Stability; D007700:Kinetics; D051379:Mice; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D002511:Cephalosporins; D002510:Cephalosporinase; D001618:beta-Lactamases