Liposomes. Effect of temperature on their mode of action on single frog skeletal muscle fibers.
Liposomes containing the fluorescent dye 6-carboxyfluorescein were made from dipalmitoyl phosphatidylcholine and stearylamine. At 4 degrees C the liposomes are adsorbed on the fiber surface and when the temperature is raised to 21 degrees C, their contents are transferred directly into the fibers at a linear rate. Liposomes had little effect on the time course of the maximal twitch tension.
D000818:Animals; D001001:Anura; D005452:Fluoresceins; D008081:Liposomes; D008856:Microscopy, Fluorescence; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000502:physiology*; D011663:Pulmonary Surfactants / Q000494:pharmacology*; D011894:Rana pipiens; D013696:Temperature
D005452:Fluoresceins; D008081:Liposomes; D011663:Pulmonary Surfactants; C024098:6-carboxyfluorescein