title: [Development of humoral immunity to heterologous antigen in the parenteral and peroral administration of pertussis vaccine].
abstract: The influence of pertussis vaccine administered by different methods on the development of humoral immune response to heterologous antigen obtained from the bovine spinal cord has been studied on rabbits. Pertussis vaccine introduced into the body of animals simultaneously with the heterologous antigen has been found to induce, besides protective anti-pertussis immunity, the development of reagin immune response to the antigen of cerebrospinal tissue. The reagin response was more pronounced in the animals receiving pertussis vaccine parenterally. At the same time, on days 10-15 after immunization by both methods a decrease in the IgG and IgM levels and their subsequent increase were registered. These data suggest that the parenteral administration of pertussis vaccine creates a higher allergic background in the body in comparison with oral immunization.
mesh_terms: D000284:Administration, Oral; D000373:Agglutinins / Q000032:analysis; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D015478:Antigens, Heterophile / Q000276:immunology*; D007114:Immunization / Q000379:methods; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007279:Injections, Subcutaneous; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology*; D011817:Rabbits; D013997:Time Factors
chemical_list: D000373:Agglutinins; D015478:Antigens, Heterophile; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010567:Pertussis Vaccine
vernacular_title: Razvitie gumoral'nogo immuniteta k geterologichnomu antigenu pri parenteral'nom i peroral'nom vvedenii kokliushnoĭ vaktsiny.