Synthesis and analgetic-antiinflammatory activity of 3,5-pyrazolidinediones bearing small-ring cycloalkyl groups.
Six 1,2-diphenyl-3,5-pyrazolidinediones substituted in the 4-position with small-ring cycloalkyl groups were prepared and tested for analgetic-antiinflammatory activity. Three of the synthesized compounds exerted an analgetic-antiinflammatory activity quantitatively superior to that of phenylbutazone used as a reference standard. In particular, one of the compounds (VI) proved twice as potent as phenylbutazone while possessing the same ulcerogenic effect.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles