Regional assignment of the gene locus for steroid sulfatase.
The gene locus for steroid sulfatase, deficiency of which causes X-linked ichthyosis, is assigned to Xp11 leads to Xpter by analysis of 24 man-Chinese hamster somatic cell hybrids. High steroid sulfatase activity in a hybrid clone having retained only part of Xq is explained by demonstration of an additional late-replicating human X chromosome. This observation confirms previous evidence for noninactivation of the STS locus.
D000818:Animals; D002874:Chromosome Mapping; D002999:Clone Cells; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D006801:Humans; D006822:Hybrid Cells; D066298:In Vitro Techniques; D012730:Sex Chromosomes / Q000648:ultrastructure*; D043266:Steryl-Sulfatase; D013429:Sulfatases / Q000235:genetics*; D014960:X Chromosome / Q000648:ultrastructure*
D013429:Sulfatases; D043266:Steryl-Sulfatase