title: Chlorambucil therapy in hairy cell leukemia: effects on lipid composition and lymphocyte subpopulations.
abstract: Two patients with progressive hairy cell leukemia following splenectomy were treated with low-dose daily chlorambucil. Both had an objective hematologic response as determined by a return to normal hematocrit and platelet count. This was also reflected in the mononuclear cell fraction by the normalization of cholesterol content, cholesterol/phospholipid ratio, and the lymphocyte subpopulations. This article confirms previous reports on the efficacy of chlorambucil in this setting and describes some morphological, and biochemical concomitant events.
mesh_terms: D000368:Aged; D001402:B-Lymphocytes; D002699:Chlorambucil / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000097:blood / Q000188:drug therapy*; D007958:Leukocyte Count; D008055:Lipids / Q000097:blood*; D008214:Lymphocytes / Q000145:classification*; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood; D013601:T-Lymphocytes
chemical_list: D008055:Lipids; D010743:Phospholipids; D002699:Chlorambucil; D002784:Cholesterol