Human T-cell malignancies: Correlative clinical, histopathologic, immunologic, and cytochemical analysis of 23 cases.
Twenty-three T-cell neoplasms were investigated for their reactivity with the OKT monoclonal antibodies and expression of certain cytochemical markers. Fourteen neoplasms with diverse histopathologic features, T-cell chronic lymphocytic leukemia, mycosis fungoides, the Sézary syndrome, T-immunoblastic sarcoma, and a pleomorphic large-cell lymphoma, expressed the T helper cell phenotype, OKT3+T4+. Nine other neoplasms displayed marked inter- and intra- tumor heterogeneity. Seven of these cases, lymphoblastic lymphoma, T-cell acute lymphoblastic leukemia, and tumors with feature of T-immunoblastic sarcoma or the multilobated lymphoma of Pinkus, expressed intrathymic phenotypes. The other 2 cases, a lymphoblastic lymphoma and a so-called Lennert's lymphoma, expressed the previously undescribed OKT3+T10+ phenotype. These studies demonstrate that the T-cell malignancies are divisible into phenotypes corresponding to normal maturational stages of T-cell differentiation and functionally distinct T-cell subsets. Such studies should provide a basis for understanding the biologic heterogeneity, clinical diversity, and significance of the variable cytomorphologic characteristics of T-cell malignant tumors and assist in the further delineation of normal human T-cell heterogeneity.
D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D002648:Child; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D006825:Hybridomas / Q000032:analysis / Q000276:immunology / Q000473:pathology; D007938:Leukemia / Q000032:analysis / Q000276:immunology* / Q000473:pathology; D007945:Leukemia, Lymphoid / Q000032:analysis / Q000276:immunology / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000032:analysis / Q000276:immunology* / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000032:analysis / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D013601:T-Lymphocytes / Q000032:analysis / Q000276:immunology* / Q000473:pathology
D000911:Antibodies, Monoclonal