Epithelioid granuloma formation requiring no T-cell function.
Muramyl dipeptide (MDP), a minimal structure in bacterial cell walls essential for their adjuvant activity, was incorporated in a water-in-oil emulsion and injected into the footpads of nude rats devoid of functional T cells. MDP thus injected evoked massive epithelioid granulomas in the draining lymph nodes, indicating that MDP induced epithelioid granuloma formation requires no T cells. This finding with other data available strongly suggest that epithelioid granulomas can be induced without immunologic reactions.
D000119:Acetylmuramyl-Alanyl-Isoglutamine; D000818:Animals; D004247:DNA / Q000096:biosynthesis; D005260:Female; D006099:Granuloma / Q000209:etiology* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D009504:Neutrophils / Q000473:pathology; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology*
D000119:Acetylmuramyl-Alanyl-Isoglutamine; D004247:DNA