title: Comparison of thyroid function in mice after various injected activities of 123I, 125I and 131I.
abstract: The radiotoxicity of 123I, 125I and 131I to the thyroid gland was compared in groups of mice subjected to activities of the three isotopes ranging from 10(-2) to 10(2) MBq. The thyroid function was determined fifteen months later on the basis of the 24-hour uptake of a tracer activity of 131I. A reduction in uptake to 20 per cent of the control value for untreated mice was found for mice injected with 35 MBq of 123I, 13 MBq of 125I and 2 . 2 MBq of 131I. On estimating the average absorbed dose in different parts of the thyroid by means of a refined method of dose calculation, that found in the cell layers surrounding the follicles seemed to be most indicative for impairment of thyroid function.
mesh_terms: D000818:Animals; D005260:Female; D006207:Half-Life; D007274:Injections, Intraperitoneal; D007457:Iodine Radioisotopes / Q000008:administration & dosage* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D011829:Radiation Dosage; D013961:Thyroid Gland / Q000502:physiology / Q000528:radiation effects*
chemical_list: D007457:Iodine Radioisotopes