Restoration of E-rosette formation by levamisole and its abrogation by autochthonous serum from cattle with squamous cell carcinoma of horn.
The effect of levamisole on the erythrocyte rosette (E-rosette) forming capacity of peripheral blood lymphocytes from eight horn cancer affected and an equal number of unaffected control animals was studied in vitro. There was an appreciable increase (from 38.75 +/- 2.91 to 56.90 +/- 2.37) in the number of E-rosette forming cells when peripheral blood lymphocytes from horn cancer affected animals were treated with levamisole. However, no significant variation in E-rosette values was noticed when peripheral blood lymphocytes from control animals were treated with this drug. This restorative effect of levamisole on E-rosetting capacity of peripheral blood lymphocytes was abrogated (mean value 39.50 +/- 3.07) when peripheral blood lymphocytes were first treated with levamisole and then incubated in the presence of 50 per cent autochthonous horn cancer serum.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D005260:Female; D006733:Horns; D007106:Immune Sera / Q000276:immunology*; D007978:Levamisole / Q000494:pharmacology*; D008297:Male; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D007106:Immune Sera; D007978:Levamisole