Placental mononuclear phagocytes as a source of interleukin-1.
Mouse and human placental tissue contains a large number of mononuclear phagocytes. These cells, isolated from placenta, were shown to produce the multifaceted immune factor interleukin-1. Activity in the supernatants of 48-hour mononuclear phagocyte cultures was associated with a 12,000- to 18,000-dalton protein, consistent with known interleukin-1 characteristics. Stimulation of phagocytosis with latex beads increased the production and release of interleukin-1 from these placental cells, which may be a useful source of this protein.
D000818:Animals; D002478:Cells, Cultured; D003470:Culture Media; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000032:analysis; D051379:Mice; D010586:Phagocytes / Q000276:immunology*; D010920:Placenta / Q000166:cytology / Q000276:immunology*
D003470:Culture Media; D007375:Interleukin-1; D007376:Interleukin-2