Pre-T cell lineage of hand-mirror cells in acute lymphoblastic leukemia.
Acute lymphoblastic leukemia was observed in a 64-year-old male patient with 50-80% hand-mirror cells in the peripheral blood and in the bone marrow. Immunologic surface marker tests indicated that the cells were non-T non-B lymphocytes; however, the addition of thymosin (fraction V) to the bone marrow cells induced the capability of mounting a positive local xenogeneic graft-versus-host reaction (GVHR), demonstrating the pre-T-cell lineage of the hand-mirror cells in this patient.
D000818:Animals; D001853:Bone Marrow / Q000276:immunology; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic; D006087:Graft vs Host Reaction; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D051381:Rats; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000166:cytology*; D013947:Thymosin / Q000494:pharmacology
D013947:Thymosin