[Morphogenesis of thymus involution during oxythiamine B1-hypovitaminosis].
Atrophy of the thymus cortex was found in rats after administration of oxythiamine. In acute experiments, atrophy was a consequence of a short-term inhibition of proliferation followed by enhancement of disintegration of small thymocytes by caryorhexis. Disintegration assumes an exceptional significance for thymus involution. Breakdown of cells correlated with a sharp decrease in thymocyte resistance to hydrocortisone. Possible metabolic reasons for the decreased resistance are discussed.
D000818:Animals; D001284:Atrophy; D002467:Cell Nucleus / Q000648:ultrastructure; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D008297:Male; D008940:Mitotic Index; D010119:Oxythiamine / Q000506:poisoning*; D051381:Rats; D013601:T-Lymphocytes / Q000187:drug effects; D013832:Thiamine Deficiency / Q000473:pathology*; D013844:Thiazoles / Q000506:poisoning*; D013950:Thymus Gland / Q000473:pathology*
D013844:Thiazoles; D010119:Oxythiamine; D006854:Hydrocortisone
K morfogenezu ivoliutisii timusa pri oksitiaminovom B1-gipovitaminoze.