title: Association between an HLA haplotype and low responsiveness to schistosomal worm antigen in man.
abstract: Immune responsiveness to schistosomal worm antigen was investigated in the individuals infected with Schistosoma japonicum by measuring the antigen-specific proliferative response of the peripheral T lymphocytes in vitro. Out of 57 infected individuals, 10 (17.5%) were low responders, whereas 47 (82.5%) were high responders to this antigen. The strong association between the HLA-Aw24-Bw52-Dw12 haplotype and the low responder group was demonstrated. Because the association of the low responder group was strongest with the HLA-D specificity, Dw12, and because the HLA-D region was assumed to be comparable to the I region of the murine H-2 complex, it was suggested that the low responsiveness to schistosomal worm antigen was controlled by a single dominant immune suppression gene that was in strong linkage disequilibrium with HLA-Dw12.
mesh_terms: D000941:Antigens / Q000276:immunology*; D005260:Female; D008040:Genetic Linkage; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D010641:Phenotype; D012549:Schistosoma japonicum / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000941:Antigens; D000949:Histocompatibility Antigens Class II