A case of chronic aneosinocytosis.
A 59-year-old woman, after complete recovery from an episode of drug-induced agranulocytosis, was found to sustain a chronic absence of recognizable mature and immature eosinophils in blood and bone marrow during a follow-up period of 8 years. Her bone marrow and peripheral blood cells cultured in vitro were able to produce normal numbers of eosinophil colonies. The present disorder was thus not caused by a lack of EO-CFU-C, nor by a defect in EO-CSA, nor by an immunologically mediated mechanism acting on mature or immature eosinophils or on EO-CSA producing cells. It is suggested that the marrow was not able to differentiate normally along the eosinophil pathway, possibly owing to a microenvironmental defect or, less likely, an intrinsic stem cell defect.
D000380:Agranulocytosis / Q000097:blood* / Q000139:chemically induced; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D002908:Chronic Disease; D003115:Colony-Stimulating Factors / Q000096:biosynthesis; D004804:Eosinophils; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008875:Middle Aged; D010424:Pentobarbital / Q000009:adverse effects
D003115:Colony-Stimulating Factors; D010424:Pentobarbital