The effect of age on circulating 6-keto-prostaglandin F1 alpha in humans.
The effect of age on the production of the antiaggregatory prostacyclin (PGI2) was studied by measuring 6-keto-PGF1 alpha in the plasma of 140 subjects (50 males and 90 females) between 10-90 years of age. The 6-keto-PGF1 alpha concentrations (mean +/- SD) in subjects between 10-20 years of age were higher (126 +/- 63 pg/ml, n = 24) than the levels in subjects between 21-30 years of age (88 +/- 30 pg/ml, n = 16), or in subjects between 51-70 years of age (88 +/- 30 pg/ml, n = 17), whereas in subjects between 71-90 years of age, the 6-keto-PGF1 alpha levels 100 +/- 59 pg/ml, n = 36) did not differ from those in subjects under 20 years of age. The 6-keto-PGF1 alpha levels in women over 70 years (118 +/- 66 pg/ml, n = 20) were higher (p = less than 0.05) than those in men of the same age (78 +/- 42 pg/ml, n = 16), but no other sex-related connections in 6-keto-PGF1 alpha concentrations were seen. Our data suggest that the PGI2 generation in vivo, as measured by 6-keto-PGF1 alpha levels in peripheral plasma, is higher in adolescence and elderly females than in the healthy adults.
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
D015121:6-Ketoprostaglandin F1 alpha