B lymphocytes in newborns.
B lymphocyte markers in 24 full term newborn infants were evaluated within four days after birth. It was demonstrated that the percentage of cells with surface immunoglobulins (SmIg) in the blood of these subjects was normal when the lymphocytes were stained with polyvalent as well as monospecific antisera. The percentage of cells bearing Fc receptors were found to be slightly, but not significantly, reduced. The ability of newborn lymphocytes to form rosettes with mouse erythrocytes was significantly reduced. The hypothesis that the B dependent system reaches complete maturity already at the first days after birth is discussed.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D011947:Receptors, Antigen, B-Cell / Q000302:isolation & purification; D011961:Receptors, Fc / Q000302:isolation & purification; D012397:Rosette Formation
D011947:Receptors, Antigen, B-Cell; D011961:Receptors, Fc