Effects of gonadectomy on foreign-body tumorigenesis in CBA/H mice.
Sarcomas were induced by sc implantation of unplasticized polyvinylchloride-vinylacetate films in gonadectomized and normal male and female CBA/H mice. Gonadectomy did not demonstrably influence tumor incidence and tumor latencies in males but significantly prolonged tumor latencies in females. The results suggest that estrogen influences the pace of foreign-body tumorigenesis in CBA/H mice.
D000818:Animals; D002369:Castration; D004195:Disease Models, Animal; D004967:Estrogens / Q000502:physiology*; D005260:Female; D005549:Foreign-Body Reaction / Q000150:complications*; D008297:Male; D051379:Mice; D012513:Sarcoma, Experimental / Q000209:etiology*; D012737:Sex Factors
D004967:Estrogens