title: Skin lesions in angioimmunoblastic lymphadenopathy: histological and immunological studies.
abstract: Angioimmunoblastic lymphadenopathy with drysproteinaemia is reported (AILD) in four patients with different skin pictures. As the disease progresses two main forms predominate; papulonodular and erythroderma. In all cases the histological picture of the skin mirrors that of the lymph-node. Our results point to an increase in the peripheral blood, lymph-nodes and skin of T and subsequently of B lymphocytes suggesting that a proliferation of helper T cells and hence activation of the B-cell subpopulation may be involved in the pathogenesis of some cases of AILD.
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002642:Chick Embryo; D005260:Female; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000276:immunology / Q000473:pathology*; D007136:Immunoglobulins / Q000032:analysis; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007136:Immunoglobulins