Anti-inflammatory and analgesic profile of amidines of 3-amino-1,2,4-benzotriazine and 3-amino-1,2,4-benzotriazine-1-oxide.
Several formamidine and acetamidine derivatives prepared from 3-amino-1,2,4-benzotriazine and 3-amino-1,2,4-benzotriazine-1-oxide displayed an aspirin-like anti-inflammatory and analgesic profile. The test systems include adjuvant-induced arthritis in rats, carrageenan-induced edema in rats, UV-induced erythema in guinea pigs, the analgesic gait test, the antipyretic test, and GI ulcer studies.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy; D002351:Carrageenan; D055598:Chemical Phenomena; D002621:Chemistry; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004890:Erythema / Q000188:drug therapy; D006168:Guinea Pigs; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced; D014227:Triazines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014227:Triazines; D002351:Carrageenan