Increase in T gamma lymphocytes in B-cell chronic lymphocytic leukaemia.
A significant increase in the proportion (mean 38% +/- 9.3 SD) and absolute number of T gamma (suppressor) lymphocytes was observed in 13 patients with chronic lymphocytic leukaemia (CLL) compared with 20 normal controls (mean 19% +/- 6.5). Conversely, the proportion of T mu (helper) lymphocytes was lower in CLL (mean 27% +/- 9.3) than in the controls (mean 40% +/- 4), although the absolute numbers were normal or increased. It is suggested that an imbalance of T-lymphocyte subsets controlling B-lymphocyte differentiation may be relevant in the pathogenesis of CLL or some of its associated features.
D001402:B-Lymphocytes / Q000276:immunology*; D002908:Chronic Disease; D006801:Humans; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007945:Leukemia, Lymphoid / Q000097:blood* / Q000209:etiology; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D011961:Receptors, Fc; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011961:Receptors, Fc