Formation of anti-N-like antibodies in dialysis patients: effect of different methods of dialyzer rinsing to remove formaldehyde.
Use of formalin to sterilize dialyzers is known to be responsible for the formation of anti-N-like antibody in long-term hemodialysis patients. Patients dialyzed as in-patients using formalin were found to be completely free of anti-N-like antibody, while among those on home dialysis, there was a high prevalence (31%) and incidence. The hospital patients were found to be receiving concentrations of formaldehyde less than 1 microgram/ml while those on home dialysis received 3-13 micrograms/ml. This is offered as an explanation for the absence of anti-N-antibody in patients using formalin-sterilized dialyzers.
D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis*; D005557:Formaldehyde; D006437:Hemodialysis, Home / Q000379:methods; D006452:Hemoglobinometry; D006801:Humans; D008951:MNSs Blood-Group System / Q000276:immunology*; D006435:Renal Dialysis / Q000379:methods*
D000888:Antibodies, Anti-Idiotypic; D008951:MNSs Blood-Group System; D005557:Formaldehyde