title: [Morphological possibilities of detecting HBc-antigen in liver tissue in chronic hepatitis and cirrhosis].
abstract: It has been shown that detection of HBc-antigen in the organ tissue requires the use of a complex of the morphologic methods: histologic, immunohistochemical and electron microscopic.  Ultrastructurally, the eosinophilic material in hepatocytic nuclei appears as flocks of electron dense granules 27 nm in size and produces intensive fluorescence with antiserum to HBc-antigen, all this pointing to the presence of deep antigen in the organ tissue.  The patients with chronic active hepatitis and active liver cirrhosis associated with the presence of HBc-antigen in the blood serum demonstrates accumulation of both the surface and deep antigen by hepatocytes.  Morphologically, the surface antigen is shown by ground glass-hepatocytes, whereas the deep one by "sand nuclei".
mesh_terms: D002908:Chronic Disease; D005455:Fluorescent Antibody Technique; D006505:Hepatitis / Q000276:immunology / Q000473:pathology*; D006512:Hepatitis B Core Antigens / Q000302:isolation & purification*; D006801:Humans; D008099:Liver / Q000276:immunology / Q000473:pathology*; D008103:Liver Cirrhosis / Q000276:immunology / Q000473:pathology*
chemical_list: D006512:Hepatitis B Core Antigens
vernacular_title: Morfologicheskie vozmozhnosti vyiavleniia HBc-antigena v tkani pecheni pri khronicheskikh gepatite i tsirroze.