title: Comparison of currently available monoclonal antibodies with conventional markers for phenotyping of one hundred acute leukemias.
abstract: One hundred acute leukemia cell samples (89 ALL, 11 AMML) derived from children's bone marrow at diagnosis were typed for the reaction with 15 monoclonal antibodies (mAbs). Subdivision in ALL-subgroups was performed according to conventional markers. Only some mAbs like VIL-Al which is directed against the cALL-antigen, can substitute polyclonal rabbit antisera. Additional subclassifications became evident by the use of mAbs for T-cell differentiated ALL forms. However, unexpected negative reactions must be taken into account as observed for all T-directed mAbs with individual T-cell ALL samples.
mesh_terms: D000208:Acute Disease; D000911:Antibodies, Monoclonal / Q000032:analysis*; D002648:Child; D006801:Humans; D007938:Leukemia / Q000276:immunology*; D007945:Leukemia, Lymphoid / Q000276:immunology; D015470:Leukemia, Myeloid, Acute / Q000276:immunology; D010641:Phenotype; D013601:T-Lymphocytes
chemical_list: D000911:Antibodies, Monoclonal