Heterogeneity of HLA-DR4 in the rheumatoid arthritis of a Chippewa band.
A high frequency of both rheumatoid arthritis (RA) and HLA-DR4 was found in a Chippewa Indian population. Multiple immunogenetic "variants" of HLA-DR4 were demonstrated, each showing a different response in mixed lymphocyte culture which corresponded to a serologic pattern of reactivity to a panel of non-DR4 B cell alloantisera. No DR4-bearing HLA haplotype or DR4 "variant" was common to subjects with RA, all of whom were DR4-positive. The implications are discussed.
D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007198:Indians, North American; D010375:Pedigree
D006680:HLA Antigens; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II