Induction of B cell differentiation in vitro by bursal epithelium.
The inductive capacity of in vitro cultured epithelium of chicken bursa of Fabricius and of its soluble products on B cells precursors was evaluated. The appearance of surface Ia-like antigens was used as an indicator of the early B cell differentiation in vitro. Cultured bursal epithelium as well as soluble substances produced by it were able to initiate B cell development; Ia alloantigens were induced by both syngeneic and allogeneic epithelia. In both cases the induced Ia antigens represented the genotype of the responding cells.
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology; D002060:Bursa of Fabricius / Q000166:cytology / Q000276:immunology; D002454:Cell Differentiation; D002642:Chick Embryo; D002645:Chickens; D003470:Culture Media; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D000949:Histocompatibility Antigens Class II
D003470:Culture Media; D000949:Histocompatibility Antigens Class II