Lymphocyte transformation to denatured type I collagen and B lymphocyte alloantigens in rheumatoid arthritis.
Peripheral blood lymphocytes transformed significantly to denatured type I collagen in 22 of 38 patients with rheumatoid arthritis (58%), 1 of 9 patients with Reiter's disease (P less than 0.05), and 9 of 32 controls (28%) (P less than 0.01). Determination of HLA antigens revealed significant differences between 24 rheumatoid arthritis (RA) patients and a control population for HLA-DRw4 (75% versus 23%). No correlation was observed between lymphocyte transformation to collagen and antibodies to collagen, rheumatoid factor, stage or duration of RA, or HLA antigens.
D000328:Adult; D000368:Aged; D016918:Arthritis, Reactive / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D003094:Collagen / Q000276:immunology / Q000494:pharmacology*; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007519:Isoantigens / Q000032:analysis*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged
D006680:HLA Antigens; D007519:Isoantigens; D003094:Collagen