Epidermal growth factor stimulates production of progesterone in cultured human choriocarcinoma cells.
Epidermal growth factor (EGF) stimulates the production of progesterone by JEG-3, a clonal strain of human choriocarcinoma cells. Stimulation occurs in a time and dose-dependent manner. In addition, EGF increases [14C]-acetate incorporation into [14C]-cholesterol in JEG-3 cells, and this may constitute its mechanism of action in enhancing progesterone synthesis.
D000818:Animals; D002460:Cell Line; D002822:Choriocarcinoma / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007700:Kinetics; D051379:Mice; D010455:Peptides / Q000494:pharmacology*; D011247:Pregnancy; D011374:Progesterone / Q000096:biosynthesis*; D014594:Uterine Neoplasms / Q000378:metabolism*
D010455:Peptides; D011374:Progesterone; D004815:Epidermal Growth Factor