title: Synthesis and pharmacological properties of some 2-pyrrolidinone Mannich bases.
abstract: N-aminoalkyl derivatives of 2-pyrrolidinone (1-5) and methylene-bis-amino derivatives (7-9) as intermediary products formed during aminoalkylation were described. Compounds 2 and 3, in doses over 30 and 20 mg/kg resp., displayed analgesic properties; compound 3 exerted also a weak anti-inflammatory action (37 mg/kg po) in the carrageenin test.
mesh_terms: D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000588:Amines / Q000138:chemical synthesis*; D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants / Q000138:chemical synthesis; D000928:Antidepressive Agents / Q000138:chemical synthesis; D001522:Behavior, Animal / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D007928:Lethal Dose 50; D008297:Male; D008352:Mannich Bases / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000588:Amines; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D000928:Antidepressive Agents; D008352:Mannich Bases; D011760:Pyrrolidinones; D006916:5-Hydroxytryptophan