title: Effects of induction of parturition in ewes with dexamethasone or oestrogen on concentrations of immunoglobulins in colostrum, and absorption of immunoglobulins by lambs.
abstract: Immunoglobulins were measured in colostral whey from untreated ewes or ewes treated on days 142-145 of gestation with 15 mg oestradiol benzoate (ODB) or 10, 17.5 or 25 mg dexamethasone m-sulfobenzoate (DEX) to induce parturition. DEX at all levels reduced the concentrations of immunoglobulins in colostrum, but ODB had no effect. In a second experiment, similar treatments of ODB and DEX were applied on day 143 of gestation. Lambs were removed from their dams at birth and fed a standard volume of pooled colostrum taken from untreated ewes. They were injected with an antigen (Brucella abortus) at 12 h and 4 weeks of age. Concentrations of immunoglobulins in blood plasma at 24 h after birth of lambs from DEX-treated ewes were lower than for lambs from untreated ewes or from those treated with ODB. Response to the antigen, monitored to 12 weeks of age, was unaffected by either drug. The impairment of transfer of immunoglobulins from ewe to lamb offers a possible explanation for the higher mortality among older lambs found previously after treatment of ewes with DEX.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D003126:Colostrum / Q000187:drug effects / Q000276:immunology*; D003168:Complement Fixation Tests; D003907:Dexamethasone / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007136:Immunoglobulins / Q000032:analysis*; D007751:Labor, Induced / Q000662:veterinary*; D007785:Lactose; D011247:Pregnancy; D012756:Sheep
chemical_list: D007136:Immunoglobulins; D004958:Estradiol; D003907:Dexamethasone; D007785:Lactose