Study on the effects of L-5HTP on the stages of sleep in man as evaluated by using sleep deprivation.
The effects of L-5HTP 200 mg on the EEG sleep pattern were investigated in normal subjects. When L-5HTP 200 mg was orally administered, only % S1 significantly decreased in comparison with the baseline. There was no change in any sleep stage on the first recovery night. On the second recovery night, % S1 significantly decreased, while % SR increased significantly. SWS did not show any change. The effects of L-5HTP 200 mg were investigated on the first recovery night after one night of sleep deprivation. SWS significantly increased on the first recovery night when a placebo was given, while this rebound increase of SWS disappeared and % S2 significantly increased on the first recovery night when L-5HTP was given. % SR significantly increased on the next night after the L-5HTP night.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000328:Adult; D006801:Humans; D009638:Norepinephrine / Q000378:metabolism; D012892:Sleep Deprivation; D012894:Sleep Stages / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects; D013997:Time Factors
D006916:5-Hydroxytryptophan; D009638:Norepinephrine