title: An epidemic of bath water fever--endotoxin alveolitis?
abstract: In August, 1978, in Linnavuori industrial community an epidemic broke reaching nearly one half of the population. The acute disease was manifested by severe respiratory symptoms, fever, cough, and dyspnea. The symptoms were connected with the use of hot water. The symptoms of the disease resembled those of allergic alveolitis or humidifier fever. The tap water of the region was found to be heavily polluted. Besides an ample microbial growth a high endotoxin concentration was found. Specific antibodies to the microbes or radiographic lung changes referring to allergic alveolitis were not found. Leukocytosis and reduced diffusion capacities indicating an inflammatory reaction at the alveolar level were in the acute phase. It may be a toxic lung inflammation caused by endotoxins, at least partly at the bronchiolar-to-alveolar level. According to the follow-up, to date the disease has not caused lung damages.
mesh_terms: D000293:Adolescent; D000328:Adult; D000542:Alveolitis, Extrinsic Allergic / Q000209:etiology*; D001494:Baths; D004196:Disease Outbreaks; D004731:Endotoxins; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012882:Skin Tests; D014871:Water Microbiology
chemical_list: D004731:Endotoxins