[Distribution of functionally differing cells in immunocompetent organs on haloperidol administration].
Haloperidol blockade of the dopaminergic system entails redistribution of functionally different cells. Suppressors of IgM and IgG response migrate, respectively, from the spleen and lymph nodes to the bone marrow whose cell transfer leads to inhibition of immune response. The data obtained indicate common regularities in cell distribution under blockade of the dopaminergic and activation of serotoninergic systems. Therefore, at the basis of inhibition of immunogenesis there lie monotypic processes of suppressor cell migration whatever the system responsible for it.
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects*; D002465:Cell Movement / Q000187:drug effects; D004306:Dose-Response Relationship, Immunologic; D006220:Haloperidol / Q000276:immunology*; D007108:Immune Tolerance / Q000187:drug effects; D007114:Immunization; D051379:Mice; D008808:Mice, Inbred CBA; D011954:Receptors, Dopamine / Q000187:drug effects / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects*
D011954:Receptors, Dopamine; D006220:Haloperidol
Raspredelenie funktsional'no otlichaiushchikhsia kletok v immunokompetentnykh organakh pri vvedenii galoperidola.