Synthesis and biological evaluation of some 5-aryl-2-amino-1,3,4-oxa(thia)diazoles.
Three series of 5-aryl-2-amino or 2-amino substituted 1,3,4-oxadiazoles (IV-XVIII) were prepared together with the corresponding series of the analogous 5-aryl-2-amino-1,3,4-thiadiazoles (XIX-XXXIII). The purpose of this work is two-fold: to study their pharmacological action in relation to the substituents bound to the positions -2 and -5, and to observe whether the isosteric substitution of the oxygen of he oxadiazolic nucleus with the sulfur leading to a thiadiazolic nucleus causes any activity variation. The AA. report and discuss the results obtained studying the antifungal as well as the antiinflammatory and antipyretic activity of the synthetized compounds.
D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis; D000927:Anticonvulsants / Q000138:chemical synthesis; D000935:Antifungal Agents / Q000138:chemical synthesis; D001522:Behavior, Animal / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D000935:Antifungal Agents; D010069:Oxadiazoles; D013830:Thiadiazoles