title: Correlation of plasma phenformin concentration with metabolic effects in normal subjects.
abstract: 1. Circulating concentrations of intermediary metabolites have been measured after administration of 50 mg of phenformin to normal subjects. 2. Phenformin caused a significant increase in blood lactate, alanine and the lactate/pyruvate ratio but did not affect blood glucose or serum insulin concentrations. 3. There was a significant correlation between the increase in blood lactate concentration after phenformin and the plasma concentration of the drug.
mesh_terms: D000328:Adult; D000409:Alanine / Q000097:blood; D001786:Blood Glucose; D006801:Humans; D007328:Insulin / Q000097:blood; D007773:Lactates / Q000097:blood; D008875:Middle Aged; D010629:Phenformin / Q000097:blood* / Q000494:pharmacology; D011773:Pyruvates / Q000097:blood
chemical_list: D001786:Blood Glucose; D007328:Insulin; D007773:Lactates; D011773:Pyruvates; D010629:Phenformin; D000409:Alanine