Receptor binding of B-norsteroids.
The binding of B-nor-analogues of glucocorticoids, estrogens and of an androgen to specific cytosol receptors was compared with that of parent compounds of the normal series. In the study of binding of B-norcortisol and related compounds rat liver cytosol was used, while in a case of B-norestrogens rat uterus cytosol and for 17 alpha-methyl-B-nortestosterone rat prostate cytosol was used. The displacement of the appropriate radioligands by B-norsteroids was remarkably lower than that caused by correspondinga steroids with normal B-ring with the exception of 17 alpha-methyl-B-nortestosterone.
D000818:Animals; D001667:Binding, Competitive; D003600:Cytosol / Q000378:metabolism; D004958:Estradiol / Q000031:analogs & derivatives / Q000378:metabolism; D004970:Estrone / Q000031:analogs & derivatives / Q000378:metabolism; D005260:Female; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009654:Norsteroids / Q000378:metabolism*; D011467:Prostate / Q000378:metabolism; D011869:Radioligand Assay; D051381:Rats; D011987:Receptors, Steroid / Q000378:metabolism*; D014599:Uterus / Q000378:metabolism
D009654:Norsteroids; D011987:Receptors, Steroid; D004970:Estrone; D004958:Estradiol; D006854:Hydrocortisone