Mutagenicity of sulphonylureas.
The 11 derivatives of beta-cytotropic sulphonylureas commonly used in the treatment of diabetes mellitus were tested in vivo in the highly sensitive sister-chromatid exchange test. Chlorpropamide and tolbutamide gave a positive reaction with a clear dose-response in Chinese hamsters and mice. The two compounds gave a mutagenic response neither in the Salmonella/mammalian-microsome mutagenicity test (with and without microsomal activation) nor in the chromosomal aberration test. In the micronucleus test, chlorpropamide was positive in 3 strains of mouse, tolbutamide in one strain. In Chinese hamsters and in rats the micronucleus test was negative with both compounds.
D000818:Animals; D002467:Cell Nucleus; D002875:Chromosomes / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005821:Genetic Techniques; D051379:Mice; D008809:Mice, Inbred C3H / Q000235:genetics; D008810:Mice, Inbred C57BL / Q000235:genetics; D009153:Mutagens; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics; D012854:Sister Chromatid Exchange; D013453:Sulfonylurea Compounds / Q000494:pharmacology*
D009153:Mutagens; D013453:Sulfonylurea Compounds