Sunscreens block the induction of epidermal ornithine decarboxylase by ultraviolet-B radiation: a new way of evaluating sunscreen efficacy in vivo.
Two proprietary sunscreen preparations containing para-aminobenzoic acid and sulisobenzone, respectively, were tested for their ability to block the induction of ornithine decarboxylase by medium wavelength ultraviolet radiation (UV-B) in the epidermis of the hairless mouse. Both preparations were effective, the sunscreen treated animals requiring more radiation for ornithine decarboxylase induction. The UV dose-dependent gradients were reduced by a mean factor of 7.35 (sulisobenzone) and 15 (PABA). These figures correlate well with other in vivo sunscreen assays. This new method provides a simple and reproducible way of evaluating sunscreens in vivo.
D010129:4-Aminobenzoic Acid / Q000494:pharmacology; D000818:Animals; D001557:Benzenesulfonates / Q000494:pharmacology; D001577:Benzophenones / Q000494:pharmacology; D002262:Carboxy-Lyases / Q000096:biosynthesis*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004790:Enzyme Induction / Q000187:drug effects; D004817:Epidermis / Q000201:enzymology*; D005260:Female; D051379:Mice; D008812:Mice, Hairless; D009955:Ornithine Decarboxylase / Q000096:biosynthesis*; D013473:Sunscreening Agents / Q000494:pharmacology*; D014466:Ultraviolet Rays
D001557:Benzenesulfonates; D001577:Benzophenones; D013473:Sunscreening Agents; C009361:sulisobenzone; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase; D010129:4-Aminobenzoic Acid