Protection by atropine against synergistic lethal effects of the Angusticeps-type toxin F7 from eastern green mamba venom and toxin I from black mamba venom.
A large dose of atropine protected mice effectively from death due to synergistic effects of an Angusticeps-type toxin, F7, isolated from eastern green mamba venom and a trypsin inhibitor homologue, toxin I, isolated from black mamba venom. Neostigmine potentiated the combined toxicity of these two toxins. It is concluded that the synergistic lethal effect of these two mamba toxins is due to massive release of acetylcholine in vivo.
D000818:Animals; D000992:Antitoxins; D001285:Atropine / Q000494:pharmacology*; D004357:Drug Synergism; D004546:Elapid Venoms / Q000037:antagonists & inhibitors* / Q000633:toxicity; D051379:Mice; D009388:Neostigmine / Q000494:pharmacology; D014118:Toxins, Biological / Q000633:toxicity
D000992:Antitoxins; D004546:Elapid Venoms; D014118:Toxins, Biological; C034915:toxin I, black mamba venom; D009388:Neostigmine; C034916:toxin F7; D001285:Atropine