Immunological phenotypes of human leukemias of the B-cell lineage.
The recent results are summarized of some immunological studies of various human leukemias of the B-cell lineage. The study of pre-B leukemias has outlined the diversity of immunoglobulin expression in leukemic cells resembling B-lymphocyte precursors and has provided insights into the biology of the progenitors of hematopoietic cells. Acute leukemia with Burkitt cells represents a very homogeneous group close to classical Burkitt's lymphoma. Mitogens are able to induce in vitro differentiation of leukemic cells from chronic lymphocytic-B leukemia and from hairy cell leukemia. Hairy cells become able to express new phenotypic characteristics after stimulation by phytohemagglutinin.
D000912:Antibodies, Neoplasm / Q000235:genetics; D000954:Antigens, Surface / Q000235:genetics*; D001402:B-Lymphocytes / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000235:genetics*; D007945:Leukemia, Lymphoid / Q000235:genetics*; D010641:Phenotype; D011971:Receptors, Immunologic / Q000235:genetics
D000912:Antibodies, Neoplasm; D000954:Antigens, Surface; D000949:Histocompatibility Antigens Class II; D011971:Receptors, Immunologic