Pre-B cell suppression by thymoma patient lymphocytes.
T lymphocytes from the blood of two thymoma patients with hypogammaglobulinaemia suppressed the in vitro proliferation of allogeneic pre-B cells. Both patients lacked pre-B and B cells in blood and bone marrow. It is possible that pre-B cells, as well as B cells, may be targets for suppression by T cells in thymoma patients with hypogammaglobulinaemia.
D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications; D001402:B-Lymphocytes / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology; D002455:Cell Division; D002478:Cells, Cultured; D006801:Humans; D007108:Immune Tolerance; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology; D013945:Thymoma / Q000150:complications / Q000276:immunology*; D013953:Thymus Neoplasms / Q000150:complications / Q000276:immunology*