[Renal histology in 44 patients with specific antibodies of soluble nuclear antigens].
The authors studied the correlations between renal histology and specific antinuclear antibodies of soluble nuclear antigens (anti-Sm, anti-RNP, anti-protein) in 44 patients with such auto-antibodies. They were mostly patients with lupus erythematosus (35/44), more rarely mixed collagen disease or Sjögren's disease. The presence of any one of the specific antibodies of nuclear antigens is not associated with any special renal prognosis; thus the presence of anti-RNP does not mean that there are no histological renal lesions. The renal prognosis depends in fact on the presence of anti-ADN native antibodies. Among the other laboratory parameters (rheumatoid factors, complement levels, cryoglobulinemia) only hypocomplementemia seems to be associated with a poor renal prognosis, the presence of rheumatoid factor has perhaps a protective role.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear; D000918:Antibody Specificity; D000941:Antigens; D002467:Cell Nucleus / Q000276:immunology*; D002648:Child; D003095:Collagen Diseases / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000276:immunology / Q000473:pathology
D000974:Antibodies, Antinuclear; D000941:Antigens
Etude de l'histologie rénale chez 44 malades porteurs d'anticorps spécifiques d'antigènes nucléaires solubles.