title: Non-T, non-B lymphomas are rare in childhood and associated with cutaneous tumor.
abstract: Tumor cells from a total of 116 children with non-Hodgkin's lymphoma were studied for their pattern of reactivity with a battery of cell markers, including their capacity for spontaneous formation of sheep erythrocyte rosettes (E-rosettes), demonstration of surface immunoglobulins (SIg), and positivity with antisera against T-cell antigens, the common acute-lymphoblastic-leukemia-associated antigen (cALLa), and Ia-like antigens. Fifty-eight children (50%) had T-cell lymphomas, including all those with mediastinal tumors. Fifty children (43%) had B-cell lymphomas, including 44 of the 45 with abdominal primaries. Eight children (7%) had non-T, non-B tumors, 4 of whom presented at a young age with cutaneous lymphoblastic tumors. These results demonstrate that the great majority of children with NHL, not leukemic at diagnosis, have tumors clearly committed to either T- or B-cell differentiation pathways and only rarely exhibit the common ALL phenotype (cALLa+, Ia+, E-, T-, SIg-), contrasting with the distribution of childhood lymphoblastic leukemias. The unusual association of these non-T, non-B cases with skin involvement has not previously been reported, raising speculation regarding patterns of lymphocyte traffic and origins of childhood lymphomas and leukemias.
mesh_terms: D000293:Adolescent; D000951:Antigens, Neoplasm / Q000276:immunology; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002471:Cell Transformation, Neoplastic; D002648:Child; D002675:Child, Preschool; D006681:HLA-D Antigens; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000276:immunology; D008223:Lymphoma / Q000150:complications / Q000276:immunology* / Q000473:pathology; D008297:Male; D009182:Mycosis Fungoides / Q000150:complications; D010641:Phenotype; D012751:Sezary Syndrome / Q000150:complications; D012878:Skin Neoplasms / Q000150:complications* / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
chemical_list: D000951:Antigens, Neoplasm; D006681:HLA-D Antigens; D000949:Histocompatibility Antigens Class II