title: Serum antibody-binding antibodies produced during a primary antibody response.
abstract: By using a solid phase radioimmunoassay we have demonstrated that immunization with either polyinosinic.polycytidylic acid (rl.rC) or TNP-Ficoll (both Tl-2 antigens) leads to the late production (day 10 to 15) of an IgG anti-antibody with specificity for the early (day 4 to 5) IgM produced in response to primary immunization. Adsorption of late sera with antigen removes anti-rl.rC or anti-TNP but does not remove anti-antibody. These results show that specific anti-antibody is found in serum during a primary immune response, and its appearance is coincident with a fall in serum anti-antigen. This suggests a possible role of autologous anti-antibody in regulation of a primary immune response.
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000917:Antibody Formation; D001666:Binding Sites, Antibody; D002417:Cattle; D004136:Dinitrobenzenes / Q000276:immunology; D005260:Female; D005362:Ficoll / Q000276:immunology; D007074:Immunoglobulin G; D007130:Immunoglobulin Idiotypes; D007075:Immunoglobulin M; D051379:Mice; D008811:Mice, Inbred DBA; D011070:Poly I-C / Q000276:immunology; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000276:immunology; D014301:Trinitrobenzenes / Q000276:immunology
chemical_list: D000888:Antibodies, Anti-Idiotypic; D004136:Dinitrobenzenes; D007074:Immunoglobulin G; D007130:Immunoglobulin Idiotypes; D007075:Immunoglobulin M; D014301:Trinitrobenzenes; D005362:Ficoll; D012710:Serum Albumin, Bovine; D011070:Poly I-C