[Comparison of the effect of 3-amino-4-mercapto-6-methylpyridazine with various antiphlogistic agents in rat models of inflammation].
The author compared the efficiency of 3-amino-4-mercapto-6-methylpyridazine (1; pyridazine S1) and some standard pharmaca by means of acute and subacute inflammation models. As evidence by the acute assay, the kaolin and carragheenin-induced oedemata of the rat paw as well as the Evans's blue excretion the potency of 1 compared with that of acetylsalicylic acid. Phenylbutazone and indomethacin exhibited a higher degree of activity. In the cotton-induced granuloma test, 1 was ineffective, whereas indomethacin applications had a powerful effect against inflammatory reactions. The results obtained during this investigation suggest that the activity spectrum of 1 is similar to that of acetylsalicylic acid.
D000818:Animals; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000378:metabolism; D002351:Carrageenan; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005070:Evans Blue; D005122:Exudates and Transudates / Q000187:drug effects; D006099:Granuloma / Q000188:drug therapy; D007213:Indomethacin / Q000494:pharmacology; D007249:Inflammation / Q000188:drug therapy*; D007616:Kaolin; D008297:Male; D010653:Phenylbutazone / Q000494:pharmacology; D011724:Pyridazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011724:Pyridazines; C034963:3-amino-4-mercapto-6-methylpyridazine; D007616:Kaolin; D005070:Evans Blue; D002351:Carrageenan; D010653:Phenylbutazone; D001241:Aspirin; D007213:Indomethacin
Wirkungsvergleich von 3-amino-4-mercapto-6-methylpyridazin mit einigen Antiphlogistica an Entzündungsmodellen der Ratte.