Lymphocytotoxic anti-LewisbH antibody.
We wish to report strong lymphocyte crossmatch incompatibility attributable to anti-Lea antibody. The prospective renal transplant recipient was Le(a-b-) and her serum contained potent anti-Lea and anti-LebH antibodies. Despite the fact that were able to demonstrate greater B lymphocyte than T lymphocyte Lewis(a+) antigenicity, this serum was capable of causing greater than 80% cytotoxicity of Le(a+) and Le(b+)O or A2 whole lymphocyte populations. Antibody activity was completely inhibited by Lewis substance. This inhibition was specific and did not interfere with HLA antibody activity.
D000017:ABO Blood-Group System; D000961:Antilymphocyte Serum; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000276:immunology*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology
D000017:ABO Blood-Group System; D000961:Antilymphocyte Serum; D006680:HLA Antigens; D007983:Lewis Blood Group Antigens