title: Abnormal erythroid progenitor cells in human preleukemia.
abstract: Ten patients with preleukemia were studied by the erythroid cell clonal culture technique. In nine of these patients, erythroid colonies derived from peripheral blood BFU-E were not observed, while the other patient had markedly decreased peripheral blood BFU-E-derived erythroid colonies in vitro. In three patients, marrow cells were also cultured and no BFU-E-derived erythroid colonies were detected. These studies indicate that immature erythroid progenitor cells, BFU-E, in patients with preleukemia are either markedly decreased in number or grossly defective in their proliferative or differentiative capacities.
mesh_terms: D000328:Adult; D000368:Aged; D001854:Bone Marrow Cells; D002469:Cell Separation; D002478:Cells, Cultured; D003470:Culture Media; D003907:Dexamethasone / Q000494:pharmacology; D004913:Erythrocytes, Abnormal / Q000187:drug effects; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011289:Preleukemia / Q000097:blood*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D003470:Culture Media; D003907:Dexamethasone