Clinical characteristics and course in patients with high titer anti-RNP antibodies.
Forty-four patients with high titers of anti-RNP antibodies, without anti-Sm or anti-nDNA antibodies, were studied retrospectively for clinical symptomatology, morbidity and mortality. Seven had died. Eleven had renal disease. Of patients with disease course greater than 7 years, only half had features of overlapping connective tissue diseases. The finding of high titer anti-RNP antibodies without anti-Sm or anti-nDNA did not appear to imply a distinct or unique clinical diagnosis or prognosis.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis*; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000276:immunology*; D002467:Cell Nucleus / Q000276:immunology; D002648:Child; D003240:Connective Tissue Diseases / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000276:immunology; D008297:Male; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000175:diagnosis / Q000276:immunology*; D009698:Nucleoproteins / Q000276:immunology*; D011379:Prognosis; D012189:Retrospective Studies; D012261:Ribonucleoproteins / Q000276:immunology*
D000974:Antibodies, Antinuclear; D009698:Nucleoproteins; D012261:Ribonucleoproteins