title: The safety of weekly plateletpheresis: effect on the donors' lymphocyte population.
abstract: Ten normal donors were monitored before, during, and after ten weekly donations of platelet concentrates prepared using the Haemonetics Model 30 blood processor. Analysis of these data indicates about a 20 per cent decrease of lymphocytes, with B cells being significantly decreased in half of these patients. While coincident immunoglobulin deficiencies did not develop in this short-term study, it is presumed that these would occur with a prolongation of platelet donations, as has been noted in previous studies. Additional studies are indicated to further delineate the lymphocyte depletion in normal platelet donors.
mesh_terms: D000328:Adult; D001402:B-Lymphocytes; D002469:Cell Separation; D006400:Hematocrit; D006514:Hepatitis B Surface Antigens; D006801:Humans; D007074:Immunoglobulin G; D007958:Leukocyte Count; D008212:Lymphocyte Depletion; D008297:Male; D010983:Plateletpheresis; D013587:Syphilis / Q000175:diagnosis; D013997:Time Factors
chemical_list: D006514:Hepatitis B Surface Antigens; D007074:Immunoglobulin G