Cerebrospinal fluid complement proteins in neurological disease.
CSF levels of C3 and C4 were similar in patients with no neurological disease, minor non-inflammatory conditions, degenerative disease and MS during relapse, but slightly lower in MS during remission and higher in patients with inflammation. All MS patients had low CSF levels of alpha 1-antitrypsin and high levels of IgG. The roles of local production and consumption of complement protein and damage to the blood-brain barrier are discussed.
D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D003176:Complement C3 / Q000134:cerebrospinal fluid*; D003181:Complement C4 / Q000134:cerebrospinal fluid*; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007249:Inflammation; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid*; D012075:Remission, Spontaneous; D000515:alpha 1-Antitrypsin / Q000134:cerebrospinal fluid
D002556:Cerebrospinal Fluid Proteins; D003176:Complement C3; D003181:Complement C4; D007074:Immunoglobulin G; D000515:alpha 1-Antitrypsin