Antibody penetration into living cells. V. Interference between two fc gamma receptor-mediated functions: antibody penetration and antibody-dependent cellular cytotoxicity.
The same Fc gamma receptor appears to be shared for two important phenomena: antibody-dependent cellular cytotoxicity (ADCC) and antibody penetration into living cells. ADCC is inhibited through interaction with the Fc gamma receptor during the antibody penetration process, indicating that both mechanisms may modulate each other in vitro.
D000328:Adult; D000974:Antibodies, Antinuclear / Q000276:immunology*; D000920:Antibody-Dependent Cell Cytotoxicity; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008937:Mitomycins / Q000494:pharmacology; D011961:Receptors, Fc / Q000276:immunology*; D012261:Ribonucleoproteins / Q000276:immunology
D000974:Antibodies, Antinuclear; D007074:Immunoglobulin G; D008937:Mitomycins; D011961:Receptors, Fc; D012261:Ribonucleoproteins