title: [Local immunomodulation in advanced Crohn disease with a cell-wall preparation of Propionibacterium granulosum KP-45].
abstract: Four patients aged 30-34 years with Crohn's disease in and advanced stage, having lasted 2 or 3 years, were treated by several injections of 10mg lyophilized cell wall material of P. granulosum strain KP-45 locally into the lesion. In all 4 cases a preceding conventional therapy with Salazopyrine and Prednisone or surgery had been unsuccessful. This local immunomodulatory treatment led to decisive improvement of the disease in all 4 cases, in 3 cases inflammatory symptoms disappeared completely. For this reason a local immunomodulation with P. granulosum KP-45 is recommended as an additional therapeutic procedure in patients who are otherwise resistant to therapy.
mesh_terms: D000328:Adult; D002473:Cell Wall / Q000276:immunology*; D003424:Crohn Disease / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008297:Male; D010587:Phagocytosis; D011424:Propionibacterium / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
vernacular_title: Lokale Immunmodulation bei fortgeschrittenem Morbus Crohn mit einem Zellwandpräparat von Propionibacterium granulosum KP-45.