Ovarian influence on mitogen responsiveness of lymphocytes from mice neonatally exposed to diethylstilbestrol.
Treatment of neonatal female mice with diethylstilbestrol (DES) resulted in a reduced response of spleen lymphocytes to concanavalin A (Con A) and lipopolysaccharide (LPS). Ovariectomy or ovariectomy plus estradiol treatment had no influence on the response to Con A in either control or DES-treated females. Ovariectomy reduced the response to LPS in control animals and eliminated the difference between control and DES-treated females. Estradiol treatment enhanced the response of ovariectomized control females to LPS and restored the difference between control and DES-treated animals. Comparison of the mitogen responsiveness during various stages of the estrous cycle showed a tendency for the response to be augmented at proestrus and metestrus, although the differences were not significant.
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001402:B-Lymphocytes / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D004054:Diethylstilbestrol / Q000633:toxicity*; D004971:Estrus; D005260:Female; D008214:Lymphocytes / Q000187:drug effects*; D051379:Mice; D008934:Mitogens / Q000494:pharmacology*; D010053:Ovary / Q000502:physiology*; D011135:Polysaccharides, Bacterial / Q000494:pharmacology; D011247:Pregnancy; D013601:T-Lymphocytes / Q000187:drug effects
D008934:Mitogens; D011135:Polysaccharides, Bacterial; D003208:Concanavalin A; D004054:Diethylstilbestrol