Application of the Salmonella typhimurium microsome test to the study of 25 drugs belonging to 5 chemical series.
25 active-principle forms of pharmaceutical drugs belonging to 5 chemical series have been tested for mutagenic activity. To screen these drugs we used the Salmonella typhimurium assay on 5-histidine-requiring strains, with and without microsomal activation. Only the 3 nitroimidazole derivatives were mutagenic for strains TA100, TA1535 and TA98.
D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004967:Estrogens / Q000494:pharmacology*; D005821:Genetic Techniques; D006146:Guanidines / Q000494:pharmacology*; D009153:Mutagens; D009593:Nitroimidazoles / Q000494:pharmacology*; D012110:Reserpine / Q000031:analogs & derivatives / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000235:genetics
D000893:Anti-Inflammatory Agents; D004967:Estrogens; D006146:Guanidines; D009153:Mutagens; D009593:Nitroimidazoles; D012110:Reserpine