Interleukin 2 production by alloantigen (H-2) activated T cells.
H-2 alloantigen-activated T cells release Interleukin 2 in response to a secondary stimulus by either Concanavalin A or alloantigen. No detectable lymphokine is released in the absence of secondary stimulation and, in the case of alloantigen restimulation, lymphokine release is antigen-specific. Once formed, however, the lymphokine shows no antigen specificity in its action. Like the precursor of the cytotoxic T cell, the precursor of the Interleukin 2-producing T cell requires two signals for its activation; alloantigen and a source of costimulator activity. Once activated, T cells will release lymphokine in response to alloantigen alone.
D000818:Animals; D000911:Antibodies, Monoclonal; D003208:Concanavalin A; D006183:H-2 Antigens; D007376:Interleukin-2 / Q000096:biosynthesis*; D007700:Kinetics; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000096:biosynthesis*; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D006183:H-2 Antigens; D007376:Interleukin-2; D008222:Lymphokines; D003208:Concanavalin A