The effect of a factor from multiple sclerosis serum on isolated T and B lymphocytes.
Lymphocyte transformation inhibition factor (LTIF) found in the serum of patients with active multiple sclerosis (MS) inhibits the mitogen-induced blast transformation of human lymphocytes. The results of these experiments demonstrate the relative specificity for the T lymphocyte by LTIF. The inhibitory effect of patient's serum on normal mitogen-stimulated lymphocytes was correlated with the level of clinical disease activity.
D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D008222:Lymphokines / Q000494:pharmacology*; D009103:Multiple Sclerosis / Q000276:immunology*; D010835:Phytohemagglutinins / Q000037:antagonists & inhibitors; D013601:T-Lymphocytes / Q000276:immunology*
D008222:Lymphokines; D010835:Phytohemagglutinins