Comparative study of fluproquazone in the management of post-operative pain.
41 patients suffering from moderate to severe pain were included in a multicentric double-blind study comparing 100 mg 4-(p-fluorophenyl)-1-isopropyl-7-methyl-2(1H)-quinazolinone (fluproquazone) to 250 mg mefenamic acid during a three-day period. Both medications produced a clinically highly relevant analgesic effect in the patient population considered. Fluproquazone appears to be significantly more effective than mefenamic acid after the first dose as well as after 6-h period. Fluproquazone was better tolerated than mefenamic acid: one and four patients, respectively, experienced side-effects in the two treatment groups. These results indicate a significantly better therapeutic profile for fluproquazone as compared to mefenamic acid in the management of post-operative pain.
D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008528:Mefenamic Acid / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D011799:Quinazolines / Q000009:adverse effects / Q000627:therapeutic use*; D052999:Quinazolinones
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011799:Quinazolines; D052999:Quinazolinones; D008528:Mefenamic Acid; C023491:fluproquazone