Immune unresponsiveness of spleen cells from lipopolysaccharide-treated mice to particulate thymus-dependent antigen. I. Evidence for differentiation signal defect.
The cellular basis of the immune unresponsiveness induced by lipopolysaccharide (LPS) was analyzed at the B and T cell level. The immunosuppressive effect of LPS is not related to altered B cell competence. Inhibition of antibody responses was observed only for thymus-dependent (TD) and not for thymus-independent antigens. In the presence of T cell-replacing factor (TRF), LPS-sensitized B lymphocytes respond to TD antigenic stimulation and differentiate into antibody-forming cells. Evidence is presented for a decreased helper activity of LPS-sensitized T lymphocytes and for a defective production of TRF in concanavalin A-stimulated spleen cells from LPS-treated mice. The implication of a cell compartment other than T is discussed.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D001402:B-Lymphocytes / Q000166:cytology; D002454:Cell Differentiation; D005260:Female; D007108:Immune Tolerance; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013154:Spleen / Q000166:cytology / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology*
D008070:Lipopolysaccharides