[Morphophysiological reaction of vital bush-like receptors of Rana temporaria to novocaine application].
Morpho-physiological reaction of alive bush-like interoceptors in the Rana temporaria isolated urinary bladder to the effect of procaine hydrochloride (PH) solution (0.5 and 0.05%) has been studied. Total impulse activity of the receptors has been studied synchronously with changes occurring in their structures. The alive receptors are revealed by means of methylene blue in concentration 1.6 X 10(-4) mol/l. PH sharply inhibits the impulse activity which is completely damped under 0.05% solution nearly in 12-13 min, and at administration of 0.5% solution--in 1-2 min. The impulse amplitude is decreasing. Morphological and tinctorial shifts, produced by PH administration, appear later--in 15-20 min on the background of a completely inhibited impulse activity and are manifested as swelling and increasing size of terminal plates, formation of varicosities on the preterminals and in the region of the Ranvier node, deterioration of staining properties and their dynamic changes.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008465:Mechanoreceptors / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000502:physiology; D011343:Procaine / Q000494:pharmacology*; D011896:Rana temporaria; D001743:Urinary Bladder / Q000294:innervation*
D011343:Procaine
Morfofiziologicheskaia reaktsiia zhivykh kustikovidnykh retseptorov Rana temporaria na deĭstvie novokaina.