Human B-cell alloantigens DC1, MT1, and LB12 are identical to each other but distinct from the HLA-DR antigen.
Some human B-lymphoblastoid cell lines are shown to express at least two types of Ia-like antigens. One antigen is defined by alloantisera to HLA-DR, and the other antigen is defined by alloantisera and a monoclonal antibody to the specificities DC1, MT1 (MB1), and LB12, which are in linkage disequilibrium with HLA-DR. The subunits of the DC1 molecule differ from those of the DR molecule. The light chains of both molecules are structurally polymorphic.
D001402:B-Lymphocytes / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D006680:HLA Antigens / Q000032:analysis*; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D046911:Macromolecular Substances; D008970:Molecular Weight; D011110:Polymorphism, Genetic
D006680:HLA Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D046911:Macromolecular Substances