Portal vein thrombosis and fatal pulmonary thromboembolism associated with oral contraceptive treatment.
We report a 33-year-old woman who took oral contraceptives for 8 years, and who developed gastrointestinal bleeding from esophageal varices. Celiac and mesenteric angiography demonstrated a portal vein thrombosis. Because of several episodes of dyspnea, a pulmonary angiogram was also performed, and showed partial or complete obstruction of both inferior pulmonary arteries with "pruning" of lower lobes. Despite immediate anticoagulant therapy, the patient died suddenly some days later. We believe that oral contraceptive treatment could have induced thromboembolic disease both in portal and pulmonary circulations in this patient.
D000328:Adult; D003276:Contraceptives, Oral / Q000009:adverse effects*; D004932:Esophageal and Gastric Varices / Q000209:etiology; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006801:Humans; D011169:Portal Vein; D011655:Pulmonary Embolism / Q000139:chemically induced* / Q000150:complications; D013927:Thrombosis / Q000139:chemically induced* / Q000150:complications
D003276:Contraceptives, Oral