[Dynamics of immunoregulator T-lymphocytes and its importance in the chemo-immunotherapy of lymphoproliferative diseases in children].
The levels of T-lymphocytes in untreated lymphoid malignancies in children and those after different schemes of chemoimmunotherapy were compared. The ratio of T-helper and T-suppressor cells changed in the course of treatment in correlation with the chemotherapeutic effect: the fraction of T mu cells practically did not change whereas the T gamma cell fraction decreased considerably in patients who revealed a good response to therapy. BCG treatment stimulated both populations but the response of T gamma cells was stronger. Transplantation of thymus was followed by an increase on T mu cells.
D000208:Acute Disease; D000293:Adolescent; D001500:BCG Vaccine / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D006689:Hodgkin Disease / Q000276:immunology / Q000628:therapy; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007938:Leukemia / Q000276:immunology / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology / Q000628:therapy; D008232:Lymphoproliferative Disorders / Q000276:immunology* / Q000628:therapy; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D013950:Thymus Gland / Q000637:transplantation
D001500:BCG Vaccine
Dinakmika immunoreguliatornykh T-limfotsitov i ee znachenie pri khimioimmunoterapii limfoproliferativnykh zabolevaniĭ u deteĭ.