Cardiovascular effects of 15(S) 15 methyl-PGF2 alpha.
The effects of 15(S) 15-methyl-PGF2 alpha were studied on the cardiovascular system of dogs. Intravenous and intravertebral artery administration of 15(S)-methyl-PGF 2 alpha induced arterial hypertensive and respiratory effects more intense and longer lasting than those observed for PGF2 alpha. Intravenous administration of 15(S) 15-methyl-PGF2 alpha induced a decrease of vascular reactivity to 1-norepinephrine and 1-epinephrine and to carotidal occlusion. Infiltration of the carotid sinus walls with 15(S) 15-methyl-PGF2 alpha decreased the baroreceptor reactivity.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001919:Bradycardia / Q000503:physiopathology; D002319:Cardiovascular System / Q000187:drug effects* / Q000503:physiopathology; D002346:Carotid Sinus / Q000187:drug effects / Q000503:physiopathology; D015237:Dinoprost; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology; D007269:Injections, Intra-Arterial; D011460:Prostaglandins F / Q000008:administration & dosage* / Q000494:pharmacology; D012119:Respiration / Q000187:drug effects; D013610:Tachycardia / Q000503:physiopathology; D014690:Venous Pressure / Q000187:drug effects; D014711:Vertebral Artery
D011460:Prostaglandins F; D015237:Dinoprost