Natulan, a bacterial mutagen requiring complex mammalian metabolic activation.
Following administration of Natulan and Escherichia coli to mice a dose-dependent increase in the frequency of induced bacterial mutations was observed. This mutation response was dependent on the route of Natulan administration and, following short exposures, was limited by the rate of metabolic activation of the compound.
D001711:Biotransformation; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000235:genetics; D005821:Genetic Techniques; D009153:Mutagens / Q000378:metabolism*; D009154:Mutation; D011344:Procarbazine / Q000494:pharmacology*; D013997:Time Factors
D009153:Mutagens; D011344:Procarbazine