Heterogeneity within the population of NK and K cells.
Using a cellular immunoadsorbant technique, we have examined the relationship between the K cell, which mediates antibody-dependent cellular cytotoxicity (ADCC) and the natural killer (NK) cell. Human peripheral blood lymphocytes (PBL) were allowed to adhere to monolayers of NK-sensitive target cells. PBL nonadherent to these monolayers and control PBL were then tested for both NK and ADCC activity by using a short-term 51Cr-release assay. The cytotoxic activity of nonadherent PBL was compared to that of control PBL by using the slope rati- method. In most cases, the extent of depletion of NK was greater than that of ADCC; however, in several experiments both activities were depleted to an equivalent extent. It is concluded that a single cell can mediate both ADCC and NK and that the selectivity of a given effector cell for NK targets depends upon the particular NK recognition site(s) that the cell bears.
D000328:Adult; D000920:Antibody-Dependent Cell Cytotoxicity; D002448:Cell Adhesion; D002462:Cell Membrane / Q000276:immunology; D006801:Humans; D007163:Immunosorbent Techniques; D007694:Killer Cells, Natural / Q000145:classification* / Q000276:immunology; D007700:Kinetics; D008212:Lymphocyte Depletion; D011961:Receptors, Fc / Q000276:immunology; D012397:Rosette Formation
D011961:Receptors, Fc