[Effects of prophylactic treatment of central nervous system leukemia in children. Analysis of CNS prophylactic treatment with cyclic high dose multichemotherapy, craniospinal irradiation, and high dose infusion of MTX].
Thirty-five children with previously untreated ALL or AUL who received CNS prophylactic therapy with 8 treatment regiments were analyzed. After eutering complete remission, patients received CNS-prophylaxis with one of the following regimens: Group A- cyclic high dose multichemotherapy plus intermittent intrathecal methotrexate (MTX); Group B-craniospinal irradiation plus intermittent intrathecal MTX; Group C-intermittent high dose intravenous MTX. Incidence of CNS-leukemia and bone marrow relapse was less frequent in Group B. EEG abnormalities were seen in 38.5% of Group A, 40% of Group B, and 28.6% of Group C respectively, but the abnormalities were transient. IQs of three groups were above 100, but IQs of CNS-leukemia patients, especially VIQs had a tendency to be low.
D000293:Adolescent; D001921:Brain / Q000528:radiation effects*; D002493:Central Nervous System Diseases / Q000473:pathology / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000473:pathology / Q000517:prevention & control*; D007945:Leukemia, Lymphoid / Q000473:pathology / Q000517:prevention & control; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage*; D009361:Neoplasm Invasiveness; D011879:Radiotherapy Dosage; D013116:Spinal Cord / Q000528:radiation effects*
D008727:Methotrexate