Is prevention of hypertension after open heart surgery possible by blocking 5HT2-receptors with ketanserin?
Eleven patients undergoing coronary or aortic valve surgery received ketanserin (3 X 10 mg i.v.). When surgery was finished hemodynamic measurements were performed prior to and after cessation of nitrous oxide. The results were compared with those of a control group (n = 30), reported in a previous study. At the end of operation the ketanserin treated patients had significantly lower heart rate (84 +/- 16 vs. 96 +/- 14 min-1; Mean +/- S.D.), lower mean arterial pressure (75 +/- 12 vs. 84 +/- 10 mmHg) and higher skin temperature (31.9 +/- 1.3 vs. 27.7 +/- 2.3 degrees C). However, postoperative hypertension after the withdrawal of nitrous oxide was not prevented: similarly as in the control group blood pressure rose and systemic vascular resistance increased. As the last dose of ketanserin was given 60 minutes before the end of anesthesia it is likely that the effect of ketanserin had already worn off.
D000328:Adult; D000368:Aged; D000758:Anesthesia; D001021:Aortic Valve; D001026:Coronary Artery Bypass; D006350:Heart Valve Prosthesis; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000517:prevention & control*; D007275:Injections, Intravenous; D007650:Ketanserin; D008875:Middle Aged; D009609:Nitrous Oxide; D010880:Piperidines / Q000008:administration & dosage / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*
D010880:Piperidines; D012702:Serotonin Antagonists; D007650:Ketanserin; D009609:Nitrous Oxide