Presence of monocytes in systemic lupus erythematosus-associated glomerulonephritis: marker study and significance.
The presence and significance of monocytes in the glomerular lesions of 13 renal specimens obtained from ten patients with systemic lupus erythematosus-associated nephritis were studied. The monocytes were identified by the presence of intracytoplasmic lysozyme, as demonstrated by immunoperoxidase staining on paraffin-embedded tissue. Eight specimens obtained from six patients displayed monocytes. These were found most often associated with mesangial hypercellularity, and their appearance fluctuated with it. There was a positive correlation between the number of lysozyme-positive cells and the amount of proteinuria. We conclude that monocytes contribute to the endocapillary hypercellularity and affect protein filtration in lupus nephritis.
D000974:Antibodies, Antinuclear / Q000097:blood; D003404:Creatinine / Q000097:blood; D005921:Glomerulonephritis / Q000145:classification / Q000150:complications*; D006801:Humans; D007668:Kidney / Q000166:cytology; D007678:Kidney Glomerulus / Q000166:cytology; D008180:Lupus Erythematosus, Systemic / Q000145:classification / Q000150:complications*; D008247:Lysosomes / Q000145:classification; D009000:Monocytes / Q000166:cytology*; D011507:Proteinuria / Q000150:complications
D000974:Antibodies, Antinuclear; D003404:Creatinine