[Asphyxial shock and disseminated intravascular coagulation (DIC) in animal experiments. 3. Secondary fibrinolysis (author's transl)].
In artificially hypoxic rabbit foetuses, rising hydrogen ion concentration with excessive precipitation of fibrin in the microcirculation, with pH values between 7.0 and 6.9, was followed by discontinuation of DIC on account of predominant regular occurrence of secondary fibrinolysis. Such processes of secondary fibrinolysis, which could be inhibited by para-amino methylbenzoic acid (PAMBA), were found to be capable of re-opening completely the circulatory tracks in surviving foetuses. In other cases, they might persist beyond death and cover up pathologico-anatomic findings, if neglected.
D010129:4-Aminobenzoic Acid / Q000494:pharmacology; D000818:Animals; D001237:Asphyxia / Q000097:blood*; D004195:Disease Models, Animal; D004211:Disseminated Intravascular Coagulation / Q000097:blood*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood*; D011817:Rabbits; D012769:Shock; D062366:para-Aminobenzoates
D062366:para-Aminobenzoates; C015668:4-aminomethylbenzoic acid; D010129:4-Aminobenzoic Acid
Asphyktischer Shock und disseminierte intravasale Gerinnung (DIC) im Tierversuch. 3. Mitteilung: Die sekundäre Fibrinolyse.