Replacement therapy with arginine vasopressin in homozygous Brattleboro rats.
We studied the replacement therapy of different doses of AVP in DI rats. It is surprising that relatively high levels of plasma AVP were needed to achieve significant antidiuretic effects. Measured plasma AVP concentrations are less than those predicted from the release rates of AVP by the minipumps. This difference may be due to the subcutaneous mode of release of AVP. The study also provides evidence that urinary excretion of AVP is a good indicator of the plasma AVP level.
D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood / Q000627:therapeutic use* / Q000652:urine; D003919:Diabetes Insipidus / Q000188:drug therapy* / Q000503:physiopathology; D004231:Diuresis / Q000187:drug effects; D007671:Kidney Concentrating Ability / Q000187:drug effects; D008297:Male; D009994:Osmolar Concentration; D010953:Plasma Volume / Q000187:drug effects; D051381:Rats; D011910:Rats, Brattleboro / Q000502:physiology*; D011922:Rats, Mutant Strains / Q000502:physiology*
D001127:Arginine Vasopressin