HLA-B27 in possible ankylosing spondylitis with peripheral arthritis.
Among 86 patients selected as possibly having ankylosing spondylitis because of clinical symptoms and radiologically normal sacroiliac joints. HLA-B27 was positive in 41%. Four years later a representative sample of 38 individuals were re-examined and radiographed. HLA-B27 positive patients developed sacroiliitis as defined by radiological criteria twice as often (P less than 0.05). They also showed increased uptake of technetium 99 m upon quantitative scintigraphy with a region of interest method and more often probable or definite ankylosing spondylitis as defined by the New York criteria. Further differences between the HLA-B27 positive and negative follow-up groups concerned the frequency of clinical symptoms and peripheral arthritis. It is suggested that HLA-B27 typing may be helpful both in diagnosis and in judging the prognosis of possible or abortive ankylosing spondylitis.
D000328:Adult; D001168:Arthritis / Q000150:complications* / Q000000981:diagnostic imaging; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D015796:HLA-B27 Antigen; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D012446:Sacroiliac Joint; D013167:Spondylitis, Ankylosing / Q000150:complications / Q000276:immunology* / Q000503:physiopathology
D006680:HLA Antigens; D015796:HLA-B27 Antigen