Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia.
An infrequent (2-3%) B lymphocyte subpopulation was found in the normal human tonsil and lymph nodes that shows the phenotypic characteristics of B-chronic lymphocytic leukemia (B-CLL) (rosette formation with mouse erythrocytes, weak expression of membrane Ig, staining for HLA-DR, and OKT1 or Leu-1 detecting a T cell-associated p65 antigen). Preliminary evidence suggests that at least a subpopulation of these cells is found, in small proportions, within the germinal centers. These cells were not observed in the human bone marrow. B-CLL may involve this peripheral B lymphocyte subset.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001402:B-Lymphocytes / Q000145:classification / Q000276:immunology*; D002645:Chickens; D006041:Goats; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D012397:Rosette Formation
D000911:Antibodies, Monoclonal; D011947:Receptors, Antigen, B-Cell