Cold lymphocytotoxins in autoimmune haemolytic anemia.
288 sera with red cell auto-antibodies and 141 control sera were investigated for cold lymphocytotoxins (CLCT). An incidence of 72% and 40% respectively was found in patients with cold haemagglutinin disease and in those with warm IgG type AHA. The absence of increased frequency in idiopathic or methyl-dopa induced asymptomatic red cell auto-immunization would suggest that CLCT might reflect an advanced degree of auto-immune disorder. No difference was observed in reaction patterns of isolated B and T lymphocytes or of those from individuals with I negative red cell phenotype.
D000328:Adult; D000373:Agglutinins / Q000032:analysis; D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology*; D000961:Antilymphocyte Serum / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D003080:Cold Temperature; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D010265:Paraproteinemias / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000373:Agglutinins; D000961:Antilymphocyte Serum; D001323:Autoantibodies