title: [Study of the growth zone of the thymus during the spontaneous development of mammary tumors in rats].
abstract: The methods of quantitative histochemistry were employed to study a subcapsular zone of the thymus under development of spontaneous mammary tumors in rats. In case of pretumor changes (fibrous-cystic mastopathy) some alterations in the metabolism of thymocytes were noted, which were manifested in the absence of DNA gain, a reduced level of cytoplasmatic and nuclear RNA, and a lack of correlation between NADP-diaphorase and DNA dispersion. Changes in the metabolism of T-lymphocytes at the initial stage of their maturation are likely to contribute to the occurrence of immunodepression followed by tumor appearance.
mesh_terms: D000818:Animals; D004273:DNA, Neoplasm / Q000378:metabolism; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D005260:Female; D006651:Histocytochemistry; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism*; D011230:Precancerous Conditions / Q000378:metabolism; D012334:RNA, Neoplasm / Q000378:metabolism; D051381:Rats; D013601:T-Lymphocytes / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism*
chemical_list: D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D008058:Dihydrolipoamide Dehydrogenase
vernacular_title: Issledovanie rostkovoĭ zony timusa v usloviiakh razvitiia spontannykh opukholeĭ molochnoĭ zhelezy u krys.