Only B lymphocytes induce active enhancement of rat cardiac allografts.
LEW rats were immunized 7 days before (LEW X BN)F1 heart transplantation with 10(7) BN donor cells, either purified erythrocytes (RBC), peripheral blood (PBL), splenic, nylon-wool-adherent (B-enriched) or nylon-wool-nonadherent (T-enriched) lymphocytes. Allograft rejection was only significantly enhanced in animals pretreated with lymphocyte populations containing surface immunoglobulin (SIgG)-positive cells (PBL, splenic, or B-enriched lymphocytes). Recipients immunized with RBC or T-enriched lymphocytes containing few, if any, SIgG-bearing B lymphocytes showed no significant graft prolongation.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002469:Cell Separation; D006082:Graft Enhancement, Immunologic; D006085:Graft Survival; D016027:Heart Transplantation; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous