title: Mutagenicity of N-nitrosopiperazine derivatives in Saccharomyces cerevisiae.
abstract: The mutagenic properties of 8 N-nitrosopiperazines were examined in Saccharomyces cerevisiae. Forward mutations to canavanine resistance and reversions of his1-7 were induced by N'-methyl-N-nitrosopiperazine, dinitrosopiperazine, 2-methyldinitrosopiperazine, 2,5-dimethyldinitrosopiperazine, and 2,6-dimethyldinitrosopiperazine, in the presence of rat-liver homogenate. N-nitrosopiperazine, 2,3,5,6-tetramethyldinitrosopiperazine, and 4-benzoyl-3,5-dimethyldinitrosopiperazine were non-mutagenic.
mesh_terms: D002172:Canavanine / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004352:Drug Resistance, Microbial; D005821:Genetic Techniques; D009153:Mutagens; D010641:Phenotype; D010879:Piperazines / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000235:genetics
chemical_list: D009153:Mutagens; D010879:Piperazines; D002172:Canavanine