title: [2-(2-Thienyl)morpholines with CNS activity].
abstract: The synthesis and pharmacological investigation of 2-(2-thienyl)morpholine and some of its derivatives substituted on the nitrogen are described. The non-substituted compound showed interesting antidepressive properties with a pharmacological profile similar to that of imipramine.
mesh_terms: D006916:5-Hydroxytryptophan / Q000378:metabolism; D000374:Aggression / Q000187:drug effects; D000818:Animals; D000927:Anticonvulsants; D000928:Antidepressive Agents / Q000138:chemical synthesis*; D001522:Behavior, Animal / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D051379:Mice; D008996:Monoamine Oxidase Inhibitors; D009025:Morpholines / Q000138:chemical synthesis* / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D000928:Antidepressive Agents; D008996:Monoamine Oxidase Inhibitors; D009025:Morpholines; D013876:Thiophenes; D012110:Reserpine; D006916:5-Hydroxytryptophan; D010424:Pentobarbital
vernacular_title: 2-(2-Teinil)morfoline attive sul S.N.C.