The nature of hepatic lymphocytic infiltrates in the tropical splenomegaly syndrome.
The lymphocytes infiltrating the liver of patients with tropical splenomegaly syndrome (TSS) were shown to be mainly T lymphocytes. Migration of leucocytes obtained from patients with TSS was inhibited by TSS liver extract, normal liver extract and liver-specific lipoprotein. These findings suggest that the hepatic infiltrates which occur in TSS are probably caused by a cell-mediated immune response to an antigen present in liver cells.
D001402:B-Lymphocytes / Q000276:immunology; D002464:Cell Migration Inhibition; D006801:Humans; D007958:Leukocyte Count; D008074:Lipoproteins / Q000276:immunology; D008099:Liver / Q000276:immunology / Q000473:pathology*; D008214:Lymphocytes / Q000276:immunology*; D008565:Membrane Proteins; D011506:Proteins / Q000276:immunology; D013163:Splenomegaly / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology
D008074:Lipoproteins; D008565:Membrane Proteins; D011506:Proteins