Familial spontaneous pneumothorax and HLA antigens.
Twenty-three members of a family in which six persons had repeated spontaneous pneumothorces were studied for physical, chemical and genetic markers of this disease. A relationship between the HLA haplotype A2, B40, the alpha 1, antitrypsin phenotype M1 M2 and the occurrence of spontaneous pneumothorax was suggested in this family.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D006680:HLA Antigens / Q000032:analysis / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010641:Phenotype; D011030:Pneumothorax / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D012129:Respiratory Function Tests; D000515:alpha 1-Antitrypsin / Q000235:genetics
D006680:HLA Antigens; D000515:alpha 1-Antitrypsin