[Frequencies of HLA-A, C and Bf antigens in schizophrenic patients originated from Alsace (author's transl)].
A comparison of the frequency of HLA-A, B, C and Bf antigens observed in a group of 75 chronic schizophrenics and in a control group of 184, all strictly from Alsace, does not carry any argument in favour of a strong genetic association between schizophrenia and the antigens studied. In effect, the modifications observed in the schizophrenic sample--decrease in the frequency of A10 and B5 antigens, and increase of A29 and BfF--are not statistically significant when the probabilities are multiplied by the number of tested antigens. These preliminary results however do not permit to exclude the possibility of an association between schizophrenia and the tested antigens.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002874:Chromosome Mapping; D002908:Chronic Disease; D005260:Female; D005602:France; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D015788:HLA-A1 Antigen; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000235:genetics*; D012560:Schizophrenia, Catatonic / Q000235:genetics; D012562:Schizophrenia, Disorganized / Q000235:genetics; D012563:Schizophrenia, Paranoid / Q000235:genetics
D006680:HLA Antigens; D015788:HLA-A1 Antigen; D015235:HLA-B Antigens; D015236:HLA-C Antigens
Etude de la fréquence des antigènes HLA-A, B, C et Bf chez des schizophrènes d'origine alsacienne.