title: Further studies on the mitogenic and immune-modulating effects of plasminogen activator.
abstract: Plasminogen activator (PA), an enzyme which is secreted in large quantities by certain types of tumour cells, is an apparent lymphocyte mitogen. Treatment of mouse spleen cells with anti-Thy-1.2 serum plus complement prevents responsiveness, indicating that T cells are being stimulated to divide. In addition to the foregoing, we have shown that PA has the capacity to interfere with certain types of cell-mediated cytotoxicity and natural killer cell reactions in which tumour cells are employed as targets. These results suggest that PA may play an immune-modulating role which may be of importance in tumour self-defense.
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D002645:Chickens; D003602:Cytotoxicity, Immunologic; D008213:Lymphocyte Activation; D008223:Lymphoma / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D008934:Mitogens / Q000494:pharmacology*; D010960:Plasminogen Activators / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology; D014568:Urokinase-Type Plasminogen Activator / Q000494:pharmacology
chemical_list: D008934:Mitogens; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator