Inhibition of glucagon and insulin secretion from the perfused rat pancreas by a B-cell-selective somatostatin analog.
The isolated perfused rat pancreas was used to study the effects of somatostatin and the analog des-Asn5-[D-Trps, D-Ser13]-somatostatin on arginine-stimulated insulin and glucagon secretion. Even though the analog was found to inhibit glucagon secretion at concentrations of 10 and 100 ng/ml, it had a relatively more inhibitory effect on the B cell than on the A cell than did somatostatin itself. These data suggest that the A- and B-cell receptors for these two peptides differ.
D000818:Animals; D005934:Glucagon / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D051381:Rats; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000502:physiology
D007328:Insulin; D013004:Somatostatin; D005934:Glucagon