Suppression of milk drinking by the combination of fluoxetine and L-5-hydroxytryptophan in rats.
Fluoxetine, an inhibitor of serotonin uptake, when given at 10 mg/kg i.p. enhanced the suppression of milk drinking in non-fasted rats by the serotonin precursor, L-5-hydroxytryptophan, at doses of 10 and 20 mg/kg i.p. These findings support earlier evidence for a role of brain serotonin in the regulation of food intake.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000818:Animals; D003864:Depression, Chemical; D004326:Drinking / Q000187:drug effects*; D005473:Fluoxetine / Q000494:pharmacology*; D008297:Male; D008892:Milk; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011437:Propylamines; D005473:Fluoxetine; D006916:5-Hydroxytryptophan