The mechanism of transient myopia induced by sulfonamide therapy.
We performed acute and convalescent A-scan echographic ocular measurements documenting the anterior chamber depth, lens thickness, and axial length of a patient with acute transient sulfamethoxazole-induced myopia. Shallowing of the anterior chamber, independent of changes in the thickness of the lens, was the only anatomic variation found that could explain the myopia. Swelling of the ciliary body, with forward movement of the lens-iris diaphragm, could produce this transient anatomic change.
D000328:Adult; D000867:Anterior Chamber / Q000187:drug effects; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects; D002924:Ciliary Body / Q000187:drug effects; D004338:Drug Combinations / Q000009:adverse effects; D005260:Female; D006801:Humans; D007908:Lens, Crystalline / Q000187:drug effects; D009216:Myopia / Q000139:chemically induced*; D013420:Sulfamethoxazole / Q000009:adverse effects; D013449:Sulfonamides / Q000009:adverse effects*; D014295:Trimethoprim / Q000009:adverse effects; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D000892:Anti-Infective Agents, Urinary; D004338:Drug Combinations; D013449:Sulfonamides; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole