title: Analgesic and anti-inflammatory properties of 4-propionyl-4-(4-chlorophenyl)-1-(3-dimethylaminopropyl)-piperidine dihydrochloride.
abstract: 4-propionyl-4-(4-chlorophenyl)-1-(3-dimethylaminopropyl)-piperidine dihydro-chloride (S8) showed in the hot plate test a marked analgesic activity with a better therapeutic index than that of pethidine. S8 possesses also anti-inflammatory (in short and long-term tests in vivo) as well as spasmolytic properties.
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004558:Electric Stimulation; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010276:Parasympatholytics; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010276:Parasympatholytics; D010880:Piperidines; C039415:S(8)