Once daily dose treatment with a non-steroidal anti-rheumatic drug (diclofenac) in osteoarthrosis.
In a comparative, double-blind, between-patient, multicentre trial of 2 weeks' duration the efficacy and tolerability of diclofenac sodium 100 mg slow-release tablets, given either as a morning or an evening dose, were compared with that of diclofenac 50 mg enteric-coated tablets b.i.d. and placebo in 148 patients suffering from osteoarthrosis. Statistically significant differences in efficacy were shown between the two diclofenac slow-release regimes and placebo. Diclofenac 100 mg slow-release taken as a morning or an evening dose tended to be more effective than 50 mg enteric-coated tablets in a twice daily regime. The tolerability of diclofenac 100 mg slow-release and 50 mg enteric-coated b.i.d. regimes was similar and not statistically significantly different from placebo.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000008:administration & dosage* / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D010648:Phenylacetates / Q000008:administration & dosage*; D010919:Placebos; D013608:Tablets, Enteric-Coated
D003692:Delayed-Action Preparations; D010648:Phenylacetates; D010919:Placebos; D013608:Tablets, Enteric-Coated; D004008:Diclofenac