Properties of a glycopeptide isolated from human Tamm-Horsfall glycoprotein. Interaction with leucoagglutinin and anti-(human Tamm-Horsfall glycoprotein) antibodies.
A sialylated glycopeptide isolated after Pronase digestion of human Tamm-Horsfall glycoprotein behaves as a powerful monovalent hapten in the precipitin reaction between human Tamm-Horsfall glycoprotein and leucoagglutinin, but fails to inhibit the interaction of the glycoprotein with rabbit anti-(human Tamm-Horsfall glycoprotein) antibodies. The glycopeptide is much less active than the intact glycoprotein as an inhibitor of lymphocyte transformation induced by leucoagglutinin.
D000373:Agglutinins; D000888:Antibodies, Anti-Idiotypic; D006020:Glycopeptides / Q000276:immunology / Q000302:isolation & purification* / Q000494:pharmacology; D006023:Glycoproteins / Q000652:urine; D006801:Humans; D007962:Leukocytes; D008213:Lymphocyte Activation / Q000187:drug effects; D009088:Mucoproteins / Q000494:pharmacology; D011506:Proteins; D058949:Uromodulin
D000373:Agglutinins; D000888:Antibodies, Anti-Idiotypic; D006020:Glycopeptides; D006023:Glycoproteins; D009088:Mucoproteins; D011506:Proteins; C548612:UMOD protein, human; D058949:Uromodulin; C100155:leukoagglutinins, leukocytes