title: Reintroduction of anti-inflammatory drug therapy after drug-associated gastro-intestinal disturbances.
abstract: The relative risks associated with anti-inflammatory drug prescription for patients with an earlier history of drug-associated gastro-intestinal disturbance have been investigated in a retrospective study. Under these circumstances ibuprofen was well tolerated. The risks associated with modified salicylates (principally aspirin in enteric-coated form) and indomethacin suppositories also appeared to be relatively slight. Retreatment with phenylbutazone, oral indomethacin, naproxen and combination therapy was hazardous.
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001168:Arthritis / Q000188:drug therapy; D004381:Duodenal Ulcer / Q000139:chemically induced*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use; D007213:Indomethacin / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy; D010437:Peptic Ulcer / Q000139:chemically induced*; D010438:Peptic Ulcer Hemorrhage / Q000139:chemically induced; D012008:Recurrence; D012189:Retrospective Studies; D012459:Salicylates / Q000627:therapeutic use; D013488:Suppositories; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D012459:Salicylates; D013488:Suppositories; D007052:Ibuprofen; D007213:Indomethacin