title: Influence of recC and uvrD on ultraviolet-induced mutation to valine resistance in E. coli K12.
abstract: The production of mutants in E. coli exposed to ultraviolet light is initiated by photochemical reactions, and completed by metabolic processes controlled by recA and other genes. Ultraviolet-induced mutagenesis to valine resistance was measured in cells carrying recC, uvrD, or both recC and uvrD. The spontaneous and UV-induced mutagenesis was slightly greater in those carrying uvrD, as compared to recC or wild-type. At low doses, UV mutagenesis in the recC uvrD double mutant was greater than in either recC or wild-type, and was comparable to that in the uvrD strain, although this double mutant was very UV-sensitive and showed poor survival at doses above 2 J/m2.
mesh_terms: D004307:Dose-Response Relationship, Radiation; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000235:genetics* / Q000528:radiation effects; D005796:Genes; D005838:Genotype; D009154:Mutation; D011995:Recombination, Genetic; D014466:Ultraviolet Rays; D014633:Valine / Q000494:pharmacology*
chemical_list: D014633:Valine