title: Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite.
abstract: Hybrid cells secreting antibodies against sporozoites of Plasmodium berghei were obtained by fusion of plasmacytoma cells with immune murine spleen cells. The monoclonal antibodies bound to a protein with an apparent molecular weight of 44,000 (Pb44), which envelopes the surface membrane of sporozoites. Incubation of sporozoites in vitro with antibodies to Pb44 abolished their infectivity.
mesh_terms: D000818:Animals; D000906:Antibodies; D000954:Antigens, Surface; D002999:Clone Cells / Q000276:immunology; D006822:Hybrid Cells / Q000276:immunology; D008288:Malaria / Q000276:immunology*; D008565:Membrane Proteins / Q000276:immunology; D051379:Mice; D008970:Molecular Weight; D009194:Myeloma Proteins / Q000276:immunology; D009374:Neoplasms, Experimental / Q000276:immunology; D010954:Plasmacytoma / Q000276:immunology; D010962:Plasmodium berghei / Q000276:immunology*; D013154:Spleen / Q000276:immunology
chemical_list: D000906:Antibodies; D000954:Antigens, Surface; D008565:Membrane Proteins; D009194:Myeloma Proteins