The role of prostaglandins in endotoxemia: comparisons in response in the nonpregnant, maternal, and fetal models. I. Prostaglandins and the pulmonary effect of experimental endotoxemia.
The mechanism of respiratory distress in sepsis is unknown. Previous work has shown elevations of prostaglandins during sepsis. This study reveals a correlation between levels of prostaglandins F 2 alpha and E and pulmonary hypertension and other parameters of respiratory distress in oophorectomized ewes subjected to endotoxin. The use of prostaglandin synthetase inhibitors prior to endotoxin prevented the rise in prostaglandins and the development of respiratory distress.
D000818:Animals; D002369:Castration; D004731:Endotoxins / Q000097:blood; D004926:Escherichia coli; D005260:Female; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000517:prevention & control; D007052:Ibuprofen / Q000627:therapeutic use; D007213:Indomethacin / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D011458:Prostaglandins E / Q000097:blood*; D011460:Prostaglandins F / Q000097:blood*; D012128:Respiratory Distress Syndrome / Q000209:etiology; D012756:Sheep; D014115:Toxemia / Q000097:blood* / Q000150:complications
D004731:Endotoxins; D011458:Prostaglandins E; D011460:Prostaglandins F; D007052:Ibuprofen; D008775:Methylprednisolone; D007213:Indomethacin