Interrelationship between renal prostaglandin E, renin, and renal vascular tone in conscious dogs.
PGSI cause renal vasoconstriction in furosemide- and low-salt-treated dogs, but not in untreated normotensive dogs, and this effect is closely related to their control PRA. PGSI cause a lesser degree of renal vasoconstriction in 2-kidney 1-clip Goldblatt hypertensive dogs which does not correlate with their control PRA. PGSI abolish PG modulation of the renin-angiotensin system, and this effect appears to account for the increased renal vascular tone induced in furosemide- and low-salt-treated dogs.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005665:Furosemide / Q000494:pharmacology; D006973:Hypertension / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply / Q000378:metabolism*; D011458:Prostaglandins E / Q000097:blood*; D012039:Regional Blood Flow / Q000187:drug effects; D012083:Renin / Q000097:blood*; D014655:Vascular Resistance / Q000187:drug effects
D011458:Prostaglandins E; D005665:Furosemide; D012083:Renin