Considerations about the structure-activity relationships of 8-aminoquinoline antimalarial drugs.
A discussion of the structure-activity relationships (SAR) of 8-aminoquinoline antimalarial drugs is presented. Consideration is given to the potential role of metabolic transformations in the in vivo activation of 8-aminoquinolines. It is emphasized that the mechanism of action of 8-aminoquinoline agents has not yet been established and thus any analysis of SAR must be speculative.
D000634:Aminoquinolines / Q000378:metabolism*; D000818:Animals; D000962:Antimalarials / Q000378:metabolism*; D001711:Biotransformation; D004353:Drug Evaluation, Preclinical; D008253:Macaca mulatta; D010961:Plasmodium / Q000187:drug effects / Q000469:parasitology; D013329:Structure-Activity Relationship
D000634:Aminoquinolines; D000962:Antimalarials