Effect of bromocriptine treatment on the ovulatory response to oestradiol benzoate in the reflex ovulator, Microtus agrestis.
In some animals which ovulate spontaneously, oestrogen may stimulate prolactin secretion and high levels of prolactin may inhibit steroid-induced surges of LH. The possibility was investigated that such conditions were operating in the reflex ovulator Microtus agrestis to prevent spontaneous ovulation. However, bromocriptine treatment to suppress prolactin secretion did not enhance the poor ovulatory response to administration of oestradiol benzoate.
D000818:Animals; D003411:Arvicolinae / Q000502:physiology*; D001971:Bromocriptine / Q000494:pharmacology*; D003864:Depression, Chemical; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D010060:Ovulation / Q000187:drug effects*; D011388:Prolactin / Q000378:metabolism; D012377:Rodentia / Q000502:physiology*; D012636:Secretory Rate / Q000187:drug effects
D001971:Bromocriptine; D004958:Estradiol; D011388:Prolactin