[The influence of chronic exposure to lead on the formation of lung metastases in a syngeneic system (author's transl)].
Mice of strain A/J were fed for a period of 13 weeks with pellets containing lead-acetate either 300 mg/kg or 3000 mg/kg (Altromin 1314). Then the animals were injected i.v. with 500 000 of living YAC tumor cells. Nine days later the mice were killed by neck dislocation, the lung metastases were visualized by ink injection into the trachea, and the total metastatic size per lung was expressed as the square area of all metastases. Animals in both leadtreated groups showed highly significant reduction of metastatic formation in comparison with the untreated control group. This effect was even stronger expressed in the group with higher dose of lead. Various mechanisms are discussed, especially the influence of lead on immune mechanisms.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D007854:Lead / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000556:secondary*; D008223:Lymphoma / Q000276:immunology / Q000556:secondary*; D051379:Mice; D008805:Mice, Inbred A; D009942:Organometallic Compounds; D013601:T-Lymphocytes / Q000276:immunology
D009942:Organometallic Compounds; D007854:Lead; C008261:lead acetate
Der Einfluss einer chronischen Bleibelastung auf die Entwicklung von Lungenmetastasen in einem syngenetischen System.