[Pharmacokinetic studies with 3H-labelled synthetic antifibrinolytics].
In rabbits and rats pharmacokinetic studies on the anti-fibrinolytics 4-aminomethylbenzoic acid (PAMBA), trans-4-aminomethylcyclohexane-1-carboxylic acid (AMCA), and epsilon-aminocaproic acid (EACA) were carried out using the tritium labelled compounds. Following i. v. administration of PAMBA and EACA in rabbits a two-phasic plasma level and following AMCA a three-phasic plasma level was found within 7 h. The rate constants beta of 0.34 h-1, 0.44 h-1, and 1.08 h-1 for EACA, PAMBA, and AMCA, respectively, indicate a more rapid elimination of AMCA. Accordingly, the AUC-values for AMCA are considerably smaller than those for EACA and PAMBA after both i. v. and p. o. administration.
D010129:4-Aminobenzoic Acid / Q000378:metabolism; D015119:Aminocaproic Acid / Q000378:metabolism; D000818:Animals; D000933:Antifibrinolytic Agents / Q000378:metabolism*; D007700:Kinetics; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D014148:Tranexamic Acid / Q000378:metabolism; D062366:para-Aminobenzoates
D000933:Antifibrinolytic Agents; D062366:para-Aminobenzoates; C015668:4-aminomethylbenzoic acid; D014148:Tranexamic Acid; D010129:4-Aminobenzoic Acid; D015119:Aminocaproic Acid
Pharmakokinetische Untersuchungen mit 3H-markierten synthetischen Antifibrinolytica.