Plasma active vitamin D concentration in low birthweight infants with rickets and its response to vitamin D treatment.
Impairment of 25-hydroxylation may be a cause of rickets in infants of low birthweight, weighing between 2000 and 2500 g. In addition there may be impairment of 1 alpha-hydroxylation in infants weighing less than 2000 g. Our data show that a supplementary dose of vitamin D2 of at least 500 IU daily is a reasonable regimen for infants who weighed between 2000 and 2500 g at birth. However for infants who weighed less than 2000 g with a gestation of under 38 weeks, administration of 1 alpha-OHD3 may be more effective in preventing rickets.
D015652:25-Hydroxyvitamin D 2; D002117:Calcitriol; D004100:Dihydroxycholecalciferols / Q000097:blood; D004872:Ergocalciferols / Q000627:therapeutic use*; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood* / Q000627:therapeutic use*; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D012279:Rickets / Q000097:blood / Q000517:prevention & control*
D004100:Dihydroxycholecalciferols; D004872:Ergocalciferols; D006887:Hydroxycholecalciferols; D015652:25-Hydroxyvitamin D 2; D002117:Calcitriol; C008088:alfacalcidol