Effect of the new immunosuppressive agent, cyclosporin-A, on natural killer cell and antibody-dependent cell-mediated cytotoxic activity.
Athymic nude mouse homozygotes (nu/nu) and the heterozygote nu/nu+ were injected intraperitoneally with 2 mg of cyclosporin-A (CS-A) twice, 72 and 1 h prior to analysis. We have found that in vivo administration of CS-A results in a significant suppression of natural killer (NK) cell and antibody-dependent cell-mediated cytotoxic (ADCC) activity which probably play an important role in tumor and graft rejection. T cells were also suppressed, in contrast, B cells were found to be immunocompetent as determined by cell proliferation and antibody-forming capacity in response to mitogens and antigens. The identity of cells mediating NK cell and ADCC activity and its relationship to T lymphocytes are also discussed.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects*; D001402:B-Lymphocytes / Q000187:drug effects; D003524:Cyclosporins; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D007113:Immunity, Innate / Q000187:drug effects; D051379:Mice; D008819:Mice, Nude; D010456:Peptides, Cyclic / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects
D003524:Cyclosporins; D010456:Peptides, Cyclic