A double-blind comparison of dothiepin and amitriptyline in patients with primary affective disorder: serum levels and clinical response.
In a double-blind parallel group study, thirty-two patients suffering from a primary affective disorder received either dothiepin or amitriptyline. Serum concentrations of total dothiepin plus northiaden or amitriptyline and nortriptyline were estimated. A similar therapeutic response was seen with both drugs but there was no correlation with serum concentrations of amitriptyline or nortriptyline, whereas serum dothiepin correlated positively with clinical response.
D000328:Adult; D000639:Amitriptyline / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003863:Depression / Q000097:blood / Q000188:drug therapy*; D003988:Dibenzothiepins / Q000627:therapeutic use*; D004308:Dothiepin / Q000097:blood / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009661:Nortriptyline / Q000097:blood
D003988:Dibenzothiepins; D000639:Amitriptyline; D009661:Nortriptyline; D004308:Dothiepin