Dominant lethal mutation induced in male rats by 1,2-dibromo-3-chloropropane (DBCP).
1,2-Dibromoethane (DBE) and 1,2-dibromo-3-chloropropane (DBCP), soil fumigants, were investigated for their potential mutagenicity by dominant lethal studies in the rat and mouse. Dominant lethal mutation was induced by DBE in neither of the species. DBCP, on the other hand, induced dominant lethals in rats in the post-meiotic stage of spermatogenesis, especially in the early spermatid stage. However, DBCP did not cause dominant lethals in mice.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D005799:Genes, Dominant; D005804:Genes, Lethal; D005821:Genetic Techniques; D006846:Hydrocarbons, Halogenated / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009153:Mutagens; D011407:Propane / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D013045:Species Specificity
D006846:Hydrocarbons, Halogenated; D009153:Mutagens; C007318:1,2-dibromo-3-chloropropane; D011407:Propane