Effects of starvation and protein deficiency on the acute carbon tetrachloride-induced hepatotoxicity.
The effects of starvation and protein-deficient diet on the acute carbon tetrachloride (CCl4)-induced hepatotoxicity of the mice were studied histologically and histochemically. A total of 69 male mice (C57BL/6) were used and carbon tetrachloride was administered by a single subcutaneous injection at a dose of 0.1 mg/10 g body weight after starvation for 24 hours and feeding with protein-deficient diet for one month. The changes were examined consecutively. It was shown the the CCl4-induced hepatotoxicity was exaggerated by starvation and that the regeneration after centrilobular necrosis due to CCl4 administration was retarded under this condition. In the CCl4-treated group on protein-deficient diet, the centrilobular liver cells seemed to be less responsive to CCl4.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications* / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury; D004044:Dietary Proteins / Q000008:administration & dosage; D005215:Fasting; D008107:Liver Diseases / Q000473:pathology; D008115:Liver Regeneration; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011488:Protein Deficiency / Q000473:pathology*
D004044:Dietary Proteins