Effect of repeated carbon monoxide exposure to rats on cytochrome P-450 concentration and activities of monooxygenases in the liver.
To determine the possible role of cytochrome P-450 in the adaptation response of an organism to chronic carbon monoxide exposure, rats received 4, 15 or 30 subcutaneous CO injections (7.2 mmol/kg body mass; maximal COHb concentration about 56%). The concentration of cytochrome P-450 is significantly reduced after 4 injections. This effect is no longer evident following 15 or 30 CO injections, which produced distinct increases of the total hemoglobin concentration. Ethylmorphine N-demethylation is distinctly inhibited after 4, 15 and 30 CO injections, whereas the initial inhibition of ethoxycoumarin O-deethylation disappears after 30 CO administrations. Ethoxyresorufin O-deethylation is only slightly influenced by CO.
D015660:7-Alkoxycoumarin O-Dealkylase; D000818:Animals; D002248:Carbon Monoxide / Q000633:toxicity*; D002263:Carboxyhemoglobin / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis*; D005037:Ethylmorphine-N-Demethylase / Q000378:metabolism; D008099:Liver / Q000032:analysis / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010105:Oxygenases / Q000378:metabolism*; D051381:Rats
D002248:Carbon Monoxide; D003577:Cytochrome P-450 Enzyme System; D002263:Carboxyhemoglobin; D010105:Oxygenases; D015660:7-Alkoxycoumarin O-Dealkylase; D005037:Ethylmorphine-N-Demethylase