[Sex differences in the effect of acylhydrazines on temperature and pain threshold and in pharmacokinetics and tissue distribution].
It was shown that acylhydrazines derivatives display high sex selectivity during the action on normal or elevated temperature and pain threshold. Tissue distribution and the pharmacokinetics of 125I- or 131-I-p-aminobenzhydrazide in the blood of males and females were different. It is assumed that essential differences in the structure of cell membranes of males and females underlie the sex differences in the pharmacological effects of acylhydrazines.
D000814:Aniline Compounds / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D005334:Fever / Q000188:drug therapy; D006834:Hydrazines / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D051379:Mice; D051381:Rats; D012737:Sex Factors; D014018:Tissue Distribution
D000814:Aniline Compounds; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006834:Hydrazines; C034343:4-aminobenzhydrazide
Polovye razlichiia v deĭstvii atsilgidrazinov na temperaturu, bolevoĭ porog, v pharmakokinetike i tkanevom raspredelenii.