A study of some pharmacological effects of a new synthetic C-nucleoside.
The effect of a new synthetic C-nucleoside (2-beta-D-lyxopyranosyl-6,6-dimethyl-4,5,6,7-tetrahydroindol-4-one) on cell differentiation and growth was studied through three kinds of experiments: a) Appearance rate of peripheral blood cells in AKR mice, b) Growth capacity of Ehrlich ascite tumor cells and c) Reappearance rate of membrane receptors on T-lymphocytes which from E-rosette aggregates with sheep red cells. This C-nucleoside produced an inhibitory effect on all the processes studied, although not so strong as with the reference drug (methotrexate).
D000818:Animals; D000970:Antineoplastic Agents; D001772:Blood Cell Count; D001773:Blood Cells / Q000187:drug effects; D005260:Female; D045563:Indolequinones; D008297:Male; D051379:Mice; D009705:Nucleosides / Q000494:pharmacology*; D014176:Protein Biosynthesis; D011955:Receptors, Drug / Q000187:drug effects; D013601:T-Lymphocytes / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism
C026428:6,6-dimethyl-2-beta-lyxopyranosyl-4,5,6,7-tetrahydroindol-4-one; D000970:Antineoplastic Agents; D045563:Indolequinones; D009705:Nucleosides; D011955:Receptors, Drug; D013936:Thymidine