Cytogenetic studies on Burkitt's lymphoma-leukemia.
Chromosome studies on 26 cases of Burkitt's cell malignancy are reported, including 7 lymphomas and 19 acute lymphocytic leukemias. A specific translocation was found in 26 of the patients: 20 t(8;14), 4 t(8;22), and 1 t(2;8). In one other case only 2 mitoses out of 59 were found to have a probable t(8;22) translocation. Additional chromosomal abnormalities were found in 15 of the patients, irrespective of whether they had or had not been treated before cytogenetic investigation. The most remarkable was a partial duplication of chromosome 1q. The presence of additional chromosomal abnormalities together with a specific translocation allows a distinction to be made between specific and secondary chromosome anomalies. The implications of the two types of aberrations for research into the molecular mechanisms of malignancy are discussed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002051:Burkitt Lymphoma / Q000235:genetics*; D002648:Child; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000235:genetics*; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D014178:Translocation, Genetic