Host restriction of Friend leukemia virus: gag proteins of host range variants.
The host response to murine ecotropic leukemia viruses is mainly controlled by the mouse Fv-1 gene. This locus controls virus replication at an intracellular stage and prevents provirus integration. Biological studies suggest that the Fv-1 effector molecule recognizes at least one virion structural protein. We have produced host range variants of B-tropic Friend murine leukemia virus in order to study the primary structure of potential viral target proteins. Our results show that conversion of B-tropism to NB-tropism is associated with changes in the primary structure of three gag proteins--p15, p12, and p30. These results suggest that host range conversion is due to a recombinational event, presumably between the parental virus and an endogenous murine virus. They also open the possibility that p12 and p30 may be involved in host range restriction.
D000595:Amino Acid Sequence; D005622:Friend murine leukemia virus / Q000235:genetics*; D015683:Gene Products, gag; D005814:Genes, Viral; D010446:Peptide Fragments / Q000032:analysis; D011995:Recombination, Genetic; D013045:Species Specificity; D014764:Viral Proteins / Q000235:genetics* / Q000502:physiology; D014779:Virus Replication
D015683:Gene Products, gag; D010446:Peptide Fragments; D014764:Viral Proteins