Toxicological studies on 4-(hexadecylamino)benzoate (PHB), an agent with anti-atherosclerotic properties, in the rat.
The subacute oral toxicity of sodium 4-(hexadecylamino)benzoate (PHB) was studied in male and female Sprague-Dawley rats. The animals were given PHB 0, 10, 30, 100 or 300 mg/kg body weight as a 3% gum arabic suspension for 13 weeks. During PHB administration all animals on the highest dose level died or were killed because of loss of weight: there were deaths also in the 100 mg/kg group. PHB caused a leukocytopenia which was significant only at the highest dose level. The hemoglobin decreased in the two lowest dose groups. In the highest dose group the histological liver pictures were pathological. Acidophilic bodies and karyorrhexis indicating severe liver cell damage occurred at this level. In the groups receiving 30, 100 and 300 mg/kg there were foci with poorly distinguishable liver cells, mononuclear cells and some neutrophils. PHB had no noticeable toxic effects on the other organs or parameters measured.
D010129:4-Aminobenzoic Acid / Q000633:toxicity*; D062365:Aminobenzoates / Q000633:toxicity*; D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy; D005260:Female; D007970:Leukopenia / Q000139:chemically induced*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D000091402:Prohibitins; D051381:Rats; D062366:para-Aminobenzoates
D062365:Aminobenzoates; C000717332:Phb protein, rat; D000091402:Prohibitins; D062366:para-Aminobenzoates; C018246:cetaben; D010129:4-Aminobenzoic Acid