[Enhancement of the convulsant action of strychnine following administration of kynurenines into the cerebral ventricles of frogs].
In frogs (Rana temporaria) injection of L-kynurenine, quinolinic, nicotinic and picolinic acids (10 microgram) into brain ventricles potentiated the stimulant ad convulsant effects of a subthreshold dose of strychnine. Xanthurenic and anthranilic acids were ineffective. At a dose of 100 micrograms picolinic acid produced seizures in 25% of animals, quinolinic acid and L-kynurenine motor excitement in all animals, and the action of nicotinic acid was shown by severe muscle hypotonus. The doses lower than 100 g proved inactive.
D000818:Animals; D001001:Anura; D003292:Convulsants; D004357:Drug Synergism; D007276:Injections, Intraventricular; D007737:Kynurenine / Q000008:administration & dosage* / Q000633:toxicity; D009539:Nicotinic Acids / Q000008:administration & dosage; D010848:Picolinic Acids / Q000008:administration & dosage; D011805:Quinolinic Acids / Q000008:administration & dosage; D011896:Rana temporaria; D013331:Strychnine / Q000008:administration & dosage* / Q000633:toxicity; D014977:Xanthurenates / Q000008:administration & dosage; D062367:ortho-Aminobenzoates / Q000008:administration & dosage
D003292:Convulsants; D009539:Nicotinic Acids; D010848:Picolinic Acids; D011805:Quinolinic Acids; D014977:Xanthurenates; D062367:ortho-Aminobenzoates; D007737:Kynurenine; D013331:Strychnine
Usilenie sudorozhnogo deĭstviia strikhnina pri vvedenii kinureninov v zheludochki mozga liagushki.