A study of the immunosuppressive effect of allopurinol.
Allopurinol demonstrated to have an immunosuppressive action when given at the dose of 200 microgram daily to the mice receiving skin grafts. This effect was not as apparent in adult mongrel dogs receiving kidney allografts and immediate bilateral nephrectomy. If allopurinol was combined with azathioprine, however, a significant synergistic immunosuppressive effect was seen.
D000493:Allopurinol / Q000494:pharmacology*; D000818:Animals; D001379:Azathioprine / Q000494:pharmacology; D004285:Dogs; D004306:Dose-Response Relationship, Immunologic; D004357:Drug Synergism; D006085:Graft Survival; D007108:Immune Tolerance / Q000187:drug effects*; D007958:Leukocyte Count; D008214:Lymphocytes; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008811:Mice, Inbred DBA; D016038:Skin Transplantation
D000493:Allopurinol; D001379:Azathioprine