Role of T gamma and T mu sub-set lymphocytes in allergic disease.
In the present study, 48 students (30 non-atopics and 18 rhinitic allergic individuals) were studied for relative concentrations of T (E-rosette-forming sheep red blood cells) and T mu and T gamma sub-sets. Insignificant differences in T-cells were found between the two groups and only slightly higher T mu and slightly lower T gamma relative concentrations were observed. However, examinations of T mu/T gamma ratios for each individual revealed a strikingly higher ratio between these two groups, particularly in those individuals whose IgE exceeded 200 u/ml. Interpretation of the role of the T mu and T gamma sub-sets, particularly with regard to helper and supressor activities in allergic disease, is discussed in the text.
D000293:Adolescent; D000328:Adult; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D006969:Hypersensitivity, Immediate / Q000276:immunology; D007073:Immunoglobulin E / Q000096:biosynthesis; D007958:Leukocyte Count; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000145:classification*
D007073:Immunoglobulin E