Frequency and prognostic value of HLA antigens in osteosarcoma patients.
A homogeneous group of 53 Caucasian subjects with high-grade osteosarcoma (OS) was typed for HLA-A and B locus antigens. Although no significant differences in the distribution of these antigens were found in comparison with 425 local controls, a trend towards an increase of HLA-B18 and decrease of HLA-B12 was observed. All the patients underwent amputation plus adjuvant chemotherapy and among the 29 patients with a follow-up longer than one year, 9 out of 10 subjects with HLA-A3 antigens developed metastases within a few months. None of the OS patients had the HLA-A3, B7 haplotype which is present in linkage-disequilibrium in the control population.
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000276:immunology*; D005260:Female; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics; D015791:HLA-A3 Antigen; D015235:HLA-B Antigens; D059911:HLA-B18 Antigen; D015793:HLA-B7 Antigen; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000276:immunology*; D011379:Prognosis
D006680:HLA Antigens; D015791:HLA-A3 Antigen; D015235:HLA-B Antigens; D059911:HLA-B18 Antigen; D015793:HLA-B7 Antigen