Immunogenicity and reactogenicity of a Q fever chemovaccine in persons professionally exposed to Q fever in Czechoslovakia.
An immunization trial carried out on 1310 persons professionally exposed to Q fever confirmed the suitability of a chemovaccine for field use. Its immunogenicity and reactogenicity differed in three groups of subjects who differed in their previous experience of Q fever and who were given different lots of the vaccine. There was some correlation between reactogenicity of the vaccine and pre-immunization positivity in the microagglutination and skin tests as indicators of a previous exposure. The skin test was more reliable for predicting post-immunization reactions.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D001428:Bacterial Vaccines / Q000276:immunology* / Q000627:therapeutic use; D003381:Coxiella / Q000276:immunology*; D006168:Guinea Pigs; D006801:Humans; D011778:Q Fever / Q000276:immunology* / Q000517:prevention & control; D012882:Skin Tests
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines