Trans-membrane translocation of proteins. A detailed physico-chemical analysis.
A detailed, computerized procedure for analysing the translocation process of any protein with known sequence from a physico-chemical point of view is presented and used to gain a better understanding of the molecular 'rules' that govern the final outcome of the process. With the aid of this prodedure a number of testable predictions of the orientations of particular membrane-bound proteins can be made. It is also suggested that ovalbumin, the only known secreted protein lacking a cleavable prepiece, initiates translocation in a way that differs from other secreted proteins.
D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D003201:Computers; D004926:Escherichia coli / Q000378:metabolism; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D008555:Melitten / Q000378:metabolism; D008564:Membrane Potentials; D008566:Membranes / Q000378:metabolism*; D008954:Models, Biological; D010047:Ovalbumin / Q000378:metabolism; D010281:Parathyroid Hormone / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D013816:Thermodynamics
D008074:Lipoproteins; D010281:Parathyroid Hormone; D011498:Protein Precursors; D011506:Proteins; D008555:Melitten; D010047:Ovalbumin