title: Cardiac lesions in the frog induced by adrenaline.
abstract: Adrenaline (A) causes gross lesions of the ventricular wall in frogs living both at 12 degrees and 25 degrees. At 12 degrees the sensitivity of the heart to A is higher than at 25 degrees. Single or multiple ventricular aneurysm, provided by A could not be prevented by propranolol. The resistance of the myocardium towards cyanide anoxia is lowered after A especially at 25 degrees. In preliminary experiments with noradrenaline the same cardiotoxic effects are observed.
mesh_terms: D000818:Animals; D004837:Epinephrine / Q000633:toxicity*; D005260:Female; D006322:Heart Aneurysm / Q000139:chemically induced; D006331:Heart Diseases / Q000139:chemically induced*; D008297:Male; D009206:Myocardium / Q000473:pathology; D009638:Norepinephrine / Q000633:toxicity; D011433:Propranolol / Q000494:pharmacology; D011894:Rana pipiens; D013696:Temperature
chemical_list: D011433:Propranolol; D009638:Norepinephrine; D004837:Epinephrine