title: [Morphology of experimental pancreonecrosis following treatment with 5-fluorouracil].
abstract: Histological and electron microscopic study of the pancreas and biochemical determination of pancreatic enzymes in blood serum were performed in animals with experimental pancreonecrosis and after the treatment with 5-fluorouracil. The treatment resulted in the decreased secretion of pancreatic acinus tissue, diminution of destructive and inflammatory lesions and the decreased levels of trypsin, alpha-amylase and transamidinase. It is suggested that 5-fluorouracil may be used in the combined treatment of acute pancreonecrosis.
mesh_terms: D000208:Acute Disease; D000579:Amidinotransferases / Q000097:blood; D000818:Animals; D005472:Fluorouracil / Q000627:therapeutic use*; D008297:Male; D008854:Microscopy, Electron; D009336:Necrosis; D010179:Pancreas / Q000648:ultrastructure*; D010182:Pancreatic Diseases / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D014357:Trypsin / Q000097:blood; D000516:alpha-Amylases / Q000097:blood
chemical_list: D000579:Amidinotransferases; D000516:alpha-Amylases; D014357:Trypsin; D005472:Fluorouracil
vernacular_title: Morfologiia éksperimental'nogo pankreonekroza pri vozdeĭstvii 5-ftorouratsila.