Surgery and adjuvant chemotherapy with high-dose methotrexate and folinic acid rescue for infiltrating tumors of the bladder.
Thirty-three patients with category T3 or T4 bladder cancer were treated by partial or total cystectomy followed by 6 to 12 courses of high-dose methotrexate (HDMTX) with folinic acid rescue. Survival at 2 years was 90%. Two patients were treated palliatively with HDMTX alone, one of whom is alive and disease free after 35 months.
D002295:Carcinoma, Transitional Cell / Q000188:drug therapy / Q000601:surgery; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000601:surgery
D002955:Leucovorin; D008727:Methotrexate