Indoleaminergic innervation of rat choroid plexus: a fluorescence histochemical study.
Using a fluorescence histochemical technique we found that the precursor of serotonin, 5-hydroxytryptophan (5-HTP), is taken up by a population of nerve fiber-like structures, indoleaminergic in nature since selectively destroyed by the neurotoxin 6-hydroxytryptamine, within rat choroid plexus. Nerve fiber-like structures are localized within the wall of choroid blood vessels. More infrequently nerve fibers end in the stroma or in close relation to epithelial cells of the plexus. The electrolytic lesioning of raphe nuclei causes the disappearance of 5-HTP fluorescence, suggesting that these nerve fibers originate from raphe nuclei. These results suggest a direct influence of indoleaminergic pathways originating from the brainstem on the blood flow through choroid plexus as well as on the production of cerebrospinal fluid.
D006916:5-Hydroxytryptophan / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D002831:Choroid Plexus / Q000502:physiology*; D006651:Histocytochemistry; D008297:Male; D008856:Microscopy, Fluorescence; D009412:Nerve Fibers / Q000032:analysis; D051381:Rats / Q000033:anatomy & histology*; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology / Q000031:analogs & derivatives
D012701:Serotonin; C027803:6-hydroxytryptamine; D006916:5-Hydroxytryptophan