Combined tinidazole and doxycycline short term chemotherapeutic prophylaxis in gastro-intestinal surgery.
Infectious complications following gastro-intestinal surgery can be reduced with properly administered antimicrobial agents. One single preoperative dose of doxycyline (200 mg) and tinidazole (2 g) gave a highly significant reduction of infectious complications in a controlled clinical study of 307 patients undergoing elective gastro-intestinal surgery.
D002986:Clinical Trials as Topic; D013505:Digestive System Surgical Procedures; D004318:Doxycycline / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009593:Nitroimidazoles / Q000627:therapeutic use*; D011292:Premedication; D011300:Preoperative Care; D011897:Random Allocation; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014011:Tinidazole / Q000627:therapeutic use*
D009593:Nitroimidazoles; D014011:Tinidazole; D004318:Doxycycline