[Anti-inflammatory, analgesic and antipyretic properties of nonachlazine].
Nonachlazin diminishes aseptic inflammation provoked by subplantar administration of carrageenin to rats. Nonachlazin increases the sensitivity pain threshold of the rat paw affected by carrageenin-induced inflammation, decreases the reaction of mice to intraperitoneal injection of phenylchinoin, and the ability of the rabbit central nervous system for impulse summation. Nonachlazin prevents carrageenin-induced temperature rise in rats.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000188:drug therapy; D005334:Fever / Q000188:drug therapy; D005534:Foot Diseases / Q000188:drug therapy; D051379:Mice; D009628:Nonachlazine / Q000627:therapeutic use*; D010146:Pain / Q000503:physiopathology; D010640:Phenothiazines / Q000627:therapeutic use*; D051381:Rats; D012684:Sensory Thresholds / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010640:Phenothiazines; D009628:Nonachlazine
Izuchenie protivovospalitel'nykh, anal'geticheskikh i zharoponizhaiushchikh svoĭstv nonakhlazine.