Androgen-dependent sexual dimorphism of the immune system.
An androgen-dependent sexual dimorphism of the immune system was demonstrated in mice. The ration of T/B lymphocytes in the spleen was found to be significantly higher in adult females than in adult males. Furthermore, neonatal androgen administration in females gave rise to a permanent significant decrease of the T/B ratio, while neonatal castration in males resulted in a permanent increase of this ratio.
D000818:Animals; D000831:Animals, Newborn; D001402:B-Lymphocytes / Q000276:immunology*; D002369:Castration; D003602:Cytotoxicity, Immunologic; D005260:Female; D008297:Male; D051379:Mice; D012737:Sex Factors; D012741:Sexual Maturation; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone