Functional renal alterations in chronic liver diseases.
83 patients with chronic active hepatitis (CAH), 38 of them with cirrhosis, were studied and compared with 10 control subjects suffering from chronic persistent hepatitis (CPH). Tubular acidosis frequently was found in our cases. Renal plasma flow and glomerular filtration rate were significantly decreased in CAH when compared with CPH. Selective renal arteriography showed evident decrease of arterial flow in the outer cortex. Selective renal scan with 99mTc microspheres of human albumin showed a frequent escape of the tracer from the kidney to the lung. PGE1 and PGE2 levels appeared higher in the renal artery than in the vein and were significantly more elevated in 9 cases with cirrhosis vs. 13 controls. These results suggest the frequent functional impairment of the kidney also in the early stages of CAH, with an increase of PGE levels and an opening of intrarenal shunts.
D000141:Acidosis, Renal Tubular / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000792:Angiography; D001164:Arteriovenous Fistula / Q000000981:diagnostic imaging / Q000209:etiology; D002908:Chronic Disease; D005260:Female; D006505:Hepatitis / Q000097:blood / Q000150:complications*; D006801:Humans; D007668:Kidney / Q000098:blood supply; D007677:Kidney Function Tests; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011458:Prostaglandins E / Q000097:blood*; D011877:Radionuclide Imaging; D012077:Renal Artery / Q000000981:diagnostic imaging; D012082:Renal Veins / Q000000981:diagnostic imaging; D012083:Renin / Q000097:blood
D011458:Prostaglandins E; D012083:Renin