Mature bone marrow erythroid burst-forming units do not require T cells for induction of erythropoietin-dependent differentiation.
Cell-cell interactions between mature T cells and peripheral blood null cells induce erythropoietin-stimulated differentiation of peripheral blood-derived erythroid progenitors. By the use of complement-fixing cytolytic murine hybridoma and antibody uniquely reactive with mature T lymphocytes, this dependence of immature peripheral blood erythroid burst-forming unit (BFU-E) differentiation upon mature T cells or a T cell conditioned medium is confirmed. By using the same antibody, it is demonstrated that the differentiation of mature bone marrow BFU-E does not require either mature T cells or lymphocyte mitogenic factor. These findings do not preclude the presence in the bone marrow of other cells, perhaps even immature T cells, that influence erythropoietin-dependent erythroid differentiation of mature marrow BFU-E.
D001854:Bone Marrow Cells; D002454:Cell Differentiation; D002478:Cells, Cultured; D004920:Erythropoiesis; D004921:Erythropoietin / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000503:physiopathology; D013601:T-Lymphocytes / Q000276:immunology*
D004921:Erythropoietin