Trenimon-induced SCEs and structural chromosomal aberrations in early- and late-dividing lymphocytes.
In cultures of human peripheral lymphocytes the frequencies of Trenimon-induced SCEs in second post-treatment metaphases and of structural chromosomal aberrations in first, second and third post-treatment metaphases were clearly lower at late as compared with early fixation times. These results, which are discussed, indicate that T cells (early dividing) are more sensitive with respect to the induction of SCEs and structural chromosomal aberrations by Trenimon as compared with B cells (late dividing).
D000328:Adult; D001402:B-Lymphocytes / Q000187:drug effects; D002453:Cell Cycle; D002455:Cell Division; D002869:Chromosome Aberrations; D003434:Crossing Over, Genetic / Q000187:drug effects*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008677:Metaphase; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013601:T-Lymphocytes / Q000187:drug effects; D013997:Time Factors; D014228:Triaziquone / Q000494:pharmacology*
D014228:Triaziquone