Inhibitors of fibrinolysis in amniotic fluid.
Amniotic fluid inhibited the fibrinolytic, amidolytic and esterolytic activity of urokinase. Kinetic studies with AGLMe demonstrated non-competitive inhibition. A major part of the inhibitory activity could be separated from alpha 1-antitrypsin by ion-exchange chromatography on DEAE-Sephadex A-50. Plasminogen activator prepared from porcine heart was not inhibited by amniotic fluid. Amniotic fluid also inhibited the caseinolytic and amidolytic activities of plasmin.
D000653:Amniotic Fluid / Q000502:physiology*; D002364:Caseins / Q000378:metabolism; D002852:Chromatography, Ion Exchange; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D011247:Pregnancy; D014568:Urokinase-Type Plasminogen Activator / Q000037:antagonists & inhibitors; D000515:alpha 1-Antitrypsin; D000979:alpha-2-Antiplasmin / Q000494:pharmacology
D002364:Caseins; D000515:alpha 1-Antitrypsin; D000979:alpha-2-Antiplasmin; D014568:Urokinase-Type Plasminogen Activator