Toxicity and efficacy of vitrectomy fluids: amphotericin B methyl ester in the treatment of experimental fungal endophthalmitis.
The maximum nontoxic dose of amphotericin B methyl ester in vitrectomy infusion fluid was found to be 75 microgram/ml. Experimentally induced fungal endophthalmitis in rabbits was cured by vitrectomy using infusion fluid that contained 10 microgram/ml of amphotericin B methyl ester.
D000666:Amphotericin B / Q000031:analogs & derivatives / Q000627:therapeutic use / Q000633:toxicity*; D000818:Animals; D002177:Candidiasis / Q000188:drug therapy; D009877:Endophthalmitis / Q000188:drug therapy*; D005839:Gentamicins / Q000627:therapeutic use; D007263:Infusions, Parenteral; D011817:Rabbits; D014822:Vitreous Body / Q000601:surgery
D005839:Gentamicins; D000666:Amphotericin B