title: RIIIS/J mice lack a gene influencing the capacity to make an antibody response to helper T cell-independent antigens.
abstract: RIIIS/J mice lack an autosomal dominant gene(s) that has a decisive influence in determining the capacity to make an IgM antibody response to several representative helper T cell-independent antigens; these mice appear to possess functionally active helper T cells because of their ability to make a reasonably good antibody response to SRBC, a helper T cell-dependent antigen. The genetic defect involved cannot be attributed to the absence of B cells capable of giving a mitogenic response to bacterial LPS.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D005799:Genes, Dominant; D007075:Immunoglobulin M / Q000096:biosynthesis; D008070:Lipopolysaccharides / Q000276:immunology; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D007075:Immunoglobulin M; D008070:Lipopolysaccharides