title: Malignant histiocytosis of the intestine: report of three cases with immunological and cytochemical analysis.
abstract: Tumour cells from three cases of malignant histiocytosis of the intestine (MHI) have been studied immunologically and cytochemically. The cells did not form E rosettes and showed weak Fc gamma surface receptors. They contained non-specific esterase and acid phosphatase in diffuse granular distribution. In one case tumour cells showed no staining by an immunoperoxidase technique with two monoclonal anti-T cell antibodies but positive staining with a monoclonal anti-Ia-like antibody. The malignant cells from all three cases could be shown to contain alpha-1-antitrypsin. These are the first cases of MHI to have been studied in this way and the results confirm the true histiocytic--that is, monocyte/macrophage, derivation of the tumour cells in this disease.
mesh_terms: D000368:Aged; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007414:Intestinal Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D007422:Intestines / Q000032:analysis / Q000276:immunology; D008206:Lymphatic Diseases / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D007136:Immunoglobulins; D000515:alpha 1-Antitrypsin