title: Regulation of in vitro erythropoiesis by normal T cells: evidence for two T-cell subsets with opposing function.
abstract: Cellular interactions responsible for regulating in vitro erythropoiesis were studied using murine monoclonal antibodies recognizing antigens expressed by human mononuclear cells. Cell populations of interest were negatively selected by complement-dependent cytotoxicity and then evaluated for their effect on in vitro growth of erythroid burst-forming units (BFU-E). The data suggest that normal peripheral blood T cells contain at least two functionally distinct subpopulations with opposing regulatory effects: one that enhances burst formation had one that limits burst formation. Whether these effects are mediated by direct interactions of T cells with BFU-E or with auxillary cells remains to be determined.
mesh_terms: D000328:Adult; D002450:Cell Communication; D003114:Colony-Forming Units Assay; D003165:Complement System Proteins; D003602:Cytotoxicity, Immunologic; D004920:Erythropoiesis; D006801:Humans; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*
chemical_list: D003165:Complement System Proteins