T and B-cell activation by mitogenic factor generated from antigen-stimulated lymphocytes.
Guinea-pig mitogenic factor(s) were found capable of stimulating both normal T and B cells. Preliminary physicochemical characterization could not dissociate the mitogenic factors for respective cell populations. Furthermore, both immune T and B cells could produce mitogenic factors upon stimulation with antigen in contrast to some other lymphokines which are known to be produced only by immune T cells. While T-cell-derived mitogenic factor was active on both allogenic T and B cells, it was only mitogenic to syngeneic B cells and not to syngeneic T cells. B-cell-derived factor, on the other hand, could stimulate both T and B cells either of syngeneic or allogeneic origin.
D000818:Animals; D000941:Antigens / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D002850:Chromatography, Gel; D006168:Guinea Pigs; D007376:Interleukin-2 / Q000096:biosynthesis / Q000494:pharmacology*; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000494:pharmacology*; D008297:Male; D008938:Mitosis; D011817:Rabbits; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*; D013936:Thymidine / Q000378:metabolism
D000941:Antigens; D007376:Interleukin-2; D008222:Lymphokines; D013936:Thymidine