Reversal of methotrexate toxicity in mice by a calcium salt of citrovorum factor and related compounds.
The isolation of citrovorum factor from a chemically prepared mixture of the L(+/-) diastereoisomers (leucovorin) is described. The natural diastereoisomer was at least twice as effective as leucovorin in reversing methotrexate toxicity in mice.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D007536:Isomerism; D002955:Leucovorin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D008297:Male; D008727:Methotrexate / Q000037:antagonists & inhibitors / Q000633:toxicity*; D051379:Mice
D002955:Leucovorin; D008727:Methotrexate