[Effect of rubomycin and carminomycin on the delayed hypersensitivity reaction in mice immunized with ram erythrocytes].
The effect of rubomycin and carminomycin on the cellular immunity was studied on the model of delayed type hypersensitivity (DTH) in mice immunized with sheep red blood cells. It was shown that the antibiotics in the doses of 0.3-0.5 of the LD50 inhibiting the antibody formation induced intensive development of DTH. It was most pronounced on concurrent administration of the drugs or 24 hours after the immunization and did not depend on the antigen dose used for animal sensitization.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002360:Carubicin / Q000276:immunology*; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012756:Sheep / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects
D002360:Carubicin; D003630:Daunorubicin
Vliianie rubomitsina i karminomitsina na reaktsiiu gipershuvst-vitel'nosti zamedlennogo tipa u myshei, immunizirovannykh éritrotsitami barana.