title: Micellar solubilization of cetaben sodium in surfactant and lipid solutions.
abstract: Cetaben sodium solubilities were evaluated by micellar solubilization in various surfactants and lipid solvents. At pH 8, the relationship between cetaben sodium solubility and surfactant concentration delineated apparent saturable kinetics; at pH 4.9, the relationship between the two parameters was linear. In the presence of 0.5% sodium taurocholate and polysorbate 80, cetaben sodium solubility increased as the medium pH was increased; however, in the presence of 0.5% poloxamer 188, cetaben sodium solubility revealed a hyperbola when the pH was changed from 4.9 to 8.0. Cetaben sodium solubility was enhanced greatly by mixed physiological surfactants, full-strength caprylic-capric monodiglycerides or monodiglycerides, when compared to a single surfactant system. Cetaben sodium solubility is influenced by pH, surfactant type, surfactant concentration, lipid solvent type, and the simultaneous presence of surfactants or phospholipids.
mesh_terms: D010129:4-Aminobenzoic Acid; D062365:Aminobenzoates; D003102:Colloids; D006863:Hydrogen-Ion Concentration; D008055:Lipids; D008823:Micelles; D012995:Solubility; D013501:Surface-Active Agents; D062366:para-Aminobenzoates
chemical_list: D062365:Aminobenzoates; D003102:Colloids; D008055:Lipids; D008823:Micelles; D013501:Surface-Active Agents; D062366:para-Aminobenzoates; C018246:cetaben; D010129:4-Aminobenzoic Acid