Increased incidence of type I diabetes in children of older mothers.
Analysis of chart data in a large series of patients with juvenile-onset, type I diabetes shows a highly significant (P less than 0.001) increased incidence in the children born to older mothers. Diabetes was also much more frequent in the late-birth-order siblings, and this appears to be an alternative expression of advanced maternal age. This observation suggests that there may be a subset of children who eventually develop type I diabetes and are at increased risk by virtue of being born to older mothers.
D000293:Adolescent; D000328:Adult; D002648:Child; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008404:Massachusetts; D008423:Maternal Age; D008875:Middle Aged; D012306:Risk