A study of degeneration, scar formation and regeneration after section of the optic nerve in the frog, Rana pipiens.
Degeneration, scar formation and regeneration have been studied after section of the optic nerve in the frog. In the normal optic nerve two types of macroglial cell were identified: astrocytes and oligodendroglia. Degeneration after injury proceeded rapidly in comparison with mammals but did not lead to the production of a dense scar. Before much scarring had developed, regenerating axons penetrated the lesioned area.
D000818:Animals; D001345:Autoradiography; D002921:Cicatrix / Q000473:pathology; D003714:Denervation; D008854:Microscopy, Electron; D009410:Nerve Degeneration; D009416:Nerve Regeneration; D009900:Optic Nerve / Q000473:pathology / Q000502:physiology* / Q000648:ultrastructure; D011894:Rana pipiens