A syndrome of multiple immune autoreactivity. A breakdown in immune regulation.
The clinical findings of pemphigus vulgaris, rheumatoid arthritis, and Sjögren's syndrome were found in a patient displaying immunological abnormalities found in pemphigus vulgaris, systemic lupus erythematosus, rheumatoid arthritis, and Hashimoto's thyroiditis. Some of the antigen-antibody systems detected in this case were further identified. Our patient may be an example of severe failure in immune regulation.
D000974:Antibodies, Antinuclear / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000276:immunology*; D001324:Autoantigens / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology*; D003176:Complement C3 / Q000032:analysis; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008213:Lymphocyte Activation; D008875:Middle Aged; D010392:Pemphigus / Q000150:complications / Q000276:immunology*; D012261:Ribonucleoproteins / Q000276:immunology; D012859:Sjogren's Syndrome / Q000150:complications / Q000276:immunology*
D000974:Antibodies, Antinuclear; D001324:Autoantigens; D003176:Complement C3; D007136:Immunoglobulins; D012261:Ribonucleoproteins