[Study of factors of biological variations acting on the concentration of the alpha-1-serous antitrypsin in a "common population" (author's transl)].
We established by nephelometry the serous concentration in an antitrypsin alpha-1 from an example of common population of th preventive Medicine Center of VAndoeuvre-lès-Nancy (675 adults men and women). First of all, the technical qualities of the equipment (replication : 0.06) to 1.1 per cent) and the dosage method (replication : 1,6 to 2,9 per cent, reproduction 3,4 to 4,3 per cent) were estimated. We showed that the technique was well connected with the electroimmunodiffusion (r : 0.90), but that was an important dissociation between the concentrations established by the two methods. The analytical variation being known, we approached the study of biological variations. The distribution of antitrypsin alpha-1 values is quite log-normal (median : 1,71 g/l, medium : 1,76 G/l). The main factors of biological variation observed are the sex (increase in 6 to 11 per cent in women), the age (decrease in 10 per cent between 20-30 years old and 40-50 years old women), the tobacco (increase in 9,5 per cent in the men smoking more than 20 cigarettes a day), the drinking of alcohol (decrease in 10 per cent for two sexes), the taking of oral contraceptives (increase in 29 per cent). These factors of biological variation should be taken in account at the time of producing the reference values, in addition of the analytical, pathological and genetic factors.
D000328:Adult; D000368:Aged; D000375:Aging; D000428:Alcohol Drinking; D003276:Contraceptives, Oral / Q000494:pharmacology; D005260:Female; D006801:Humans; D007122:Immunoelectrophoresis; D008297:Male; D008875:Middle Aged; D009391:Nephelometry and Turbidimetry; D012737:Sex Factors; D012907:Smoking; D000515:alpha 1-Antitrypsin / Q000032:analysis*
D003276:Contraceptives, Oral; D000515:alpha 1-Antitrypsin
Etude des facteurs de variations biologiques influençant la concentration d'alpha-1-antitrypsine sérique dans une population "tout-venant".