title: Colonization and cariogenic potential in hamsters of the bacterium Streptococcus sanguis isolated from human dental plaque.
abstract: Strains of Strep. sanguis, freshly isolated from human dental plaque, were successfully implanted into albino hamsters. Transmission of the organisms from infected to uninfected animals occurred naturally. The transfer was as effective between unrelated hamsters as between dams and their offspring. Three of the strains tested did not cause caries in hamsters. Laboratory strains of Strep. sanguis did not colonize the hamsters. Two morphological variants of Strep. sanguis with different abilities to adhere to whale dentine in vitro, could infect hamsters; the more adhering phenotype was detected earlier and more frequently.
mesh_terms: D000268:Adhesiveness; D000818:Animals; D006224:Cricetinae; D003731:Dental Caries / Q000209:etiology* / Q000382:microbiology; D003773:Dental Plaque / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008963:Molar / Q000382:microbiology; D013290:Streptococcal Infections / Q000635:transmission; D013298:Streptococcus sanguis / Q000302:isolation & purification / Q000472:pathogenicity*