title: How many polymorphic genes will it take to span the human genome?
abstract: It is desirable to know how many polymorphic marker loci will be required so that every human genetic locus can be mapped by classical pedigree methods to a specific region of a specific chromosome. Assuming a total autosomal map length of 33 morgans, it would take only about 33/(2d) evenly spaced markers for every locus to be within d morgans of a marker. Taking into account that the markers will fall randomly along the genome, we show that a much larger number of such loci will have to be isolated and tested before the goal of a saturated gene map is reached.
mesh_terms: D002874:Chromosome Mapping; D005819:Genetic Markers; D006801:Humans; D008957:Models, Genetic; D010375:Pedigree; D011110:Polymorphism, Genetic; D011336:Probability
chemical_list: D005819:Genetic Markers