Self H-2 antigens influence the specificity of alloreactive cells.
We have tested Jerne's hypothesis (9) that the phenomenon alloreactivity is explained by the existence of T cells that express germline-encoded receptors specific for major histocompatibility complex antigens and that these cells undergo no change in specificity during thymic differentiation. T cells from [F1 leads to Parent] bone marrow radiation chimeras reactive to conventional antigens are known to have a self preference, i.e., [A X B leads to A] chimeras respond better to H-2A-plus-antigen than to H-2B-plus-antigen. We show here that alloreactive cells from such chimeras also have a self preference. Thus, H-2k-specific alloreactive T cells from [H-2b X H-2d leads to H-2b] and [H-2b X H-2d leads to H-2d] chimeras cross-react more on TNP-modified H-2b or H-2d targets, respectively. In contrast to Jerne's prediction, the results suggest that the receptor repertoire of alloreactive F1 cells is influenced by H-2 antigens on radiation-resistant cells present during T cell ontogeny. By this criterion of having a self preference in H-2 restriction, alloreactive T cells appear to be similar to T cells that respond to conventional antigens.
D000818:Animals; D000941:Antigens; D001324:Autoantigens; D002454:Cell Differentiation; D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D006183:H-2 Antigens; D006241:Haptens; D007111:Immunity, Cellular; D051379:Mice; D011828:Radiation Chimera; D011971:Receptors, Immunologic; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology*; D014301:Trinitrobenzenes / Q000276:immunology
D000941:Antigens; D001324:Autoantigens; D006183:H-2 Antigens; D006241:Haptens; D011971:Receptors, Immunologic; D014301:Trinitrobenzenes