Thymus derived rosette forming cell counts and lymphocyte response to phytohaemagglutinin in animals affected with squamous cell carcinoma of horn.
A non-immune erythrocyte rosette test was used to examine the levels of thymus derived lymphocytes in the peripheral blood of 12 bovine horn cancer patients and an equal number of age-matched unaffected controls. The proportion of rosette forming cells (RFC) in horn cancer affected animals was found to be approximately half that of unaffected controls. Phytohaemagglutinin was used to examine lymphocyte transformation (LT), in vitro, of lymphocytes from the peripheral blood of six horn cancer affected animals as well as unaffected controls. Transformation values in affected animals were found to be much lower than in age-matched controls. Lower values of RFC as well as LT in the horn cancer affected animals compared with unaffected controls are suggestive of depression of cell mediated immunity in this condition.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D005260:Female; D006733:Horns; D008213:Lymphocyte Activation; D008297:Male; D010835:Phytohemagglutinins / Q000494:pharmacology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D010835:Phytohemagglutinins