title: Hairy cell leukemia and myelomatosis: chance association or clinical manifestations of the same B-cell disease spectrum.
abstract: We describe three patients who had typical features of hairy cell leukemia (HCL) and multiple myeloma (MM) at the same time. In two, both diagnoses were made within a short period of time, and in the third, HCL had been present for 2 yr before the appearance of a paraprotein, bone lesions, and plasma-cell infiltrates established the diagnosis of MM. Although this association has not been previously reported, cases of HCL with osteolytic lesions or a paraprotein band have been described. The cases described may represent clinical manifestations of closely related disorders arising from divergent differentiation from a common B-cell precursor rather than a chance association.
mesh_terms: D000368:Aged; D001402:B-Lymphocytes; D002471:Cell Transformation, Neoplastic; D005260:Female; D005269:Femur / Q000293:injuries; D050723:Fractures, Bone / Q000473:pathology; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000097:blood / Q000150:complications* / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications*; D009369:Neoplasms / Q000175:diagnosis*; D010014:Osteolysis; D010266:Paraproteins
chemical_list: D010266:Paraproteins