title: Gastrointestinal blood loss, gastroscopy and coagulation factors in normal volunteers during administration of acetylsalicylic acid and fluproquazone.
abstract: The influence of one week's treatment of fluproquazone, 300 mg daily, and acetylsalicylic acid (Aspirin, Bayer), 3000 mg daily, on the gastro-intestinal tract and coagulation factors was compared in a randomized cross-over study in 12 healthy male volunteers. Gastroscopy revealed two acute erosions after fluproquazone in one subject, whereas 11 of the 12 subjects showed a total of about 80 erosions, petechiae or diffuse bleeding after aspirin. Median faecal blood loss, as assessed by means of 51Cr tagging and measurement of bulk radioactivity in a whole-body counter, were significantly (p less than 0.01) raised, from 1.8 (range 0-6.5) ml during the preceding control week to 6.0 (range 1.9-10.5) ml after treatment with aspirin. No significant difference was recorded between control and treatment weeks with fluproquazone. Mean bleeding time was significantly increased by 40% with aspirin, whereas no statistically significant change was observed with fluproquazone. The prostaglandin synthesis was not significantly influenced by fluproquazone but was almost completely suppressed by aspirin. Coagulation factor II-VII-X decreased slightly, but remained within the normal range with both drugs. This study demonstrated a markedly smaller effect of fluproquazone compared with aspirin on the gastro-intestinal tract and on haemostatic factors.
mesh_terms: D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D001780:Blood Coagulation Tests; D005243:Feces / Q000032:analysis; D005753:Gastric Mucosa / Q000187:drug effects; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D005773:Gastroscopy; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D008297:Male; D011799:Quinazolines / Q000009:adverse effects*; D052999:Quinazolinones
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011799:Quinazolines; D052999:Quinazolinones; D001241:Aspirin; C023491:fluproquazone