Survival of Loa loa following transplantation from drills (Mandrillus leucophaeus) into jirds (Meriones unguiculatus): parasitology and pathology.
Two drills infected with Loa loa maintained a microfilaraemia for four and a half years ranging from less than 1 mf/100 microliters to 1150 mf/100 microliters. No significant tissue reactions to the adult worms were seen at autopsy. Adult worms were transplanted into the peritoneal cavities of naive jirds when a persistent microfilaraemia first developed by 17 days. Retransplantation of adult worms into naive jirds produced a microfilaraemia and microfilariae in the peritoneal cavities of three out of five animals. These three animals were all negative for circulating parasites by eight and a half months. The tissue reactions to the worms in the jirds are described, including a granulomatous response surrounding adults and a myositis involving microfilariae.
D000818:Animals; D003238:Connective Tissue / Q000473:pathology; D005260:Female; D005368:Filariasis / Q000469:parasitology*; D005849:Gerbillinae / Q000469:parasitology*; D006790:Host-Parasite Interactions; D008117:Loa / Q000254:growth & development* / Q000472:pathogenicity; D008118:Loiasis / Q000469:parasitology* / Q000473:pathology; D008297:Male; D008842:Microfilariae; D009132:Muscles / Q000473:pathology; D010215:Papio / Q000469:parasitology