Analysis of yeast ilv 1 CIS control and domain mutants.
We have identified a cis control region specific for the ilv 1 gene of Saccharomyces cerevisiae. Mutants designated ilv 1-OPc map in this control region located between arg 6 and ilv 1 and result in increased basal levels and constitutive synthesis of the ilv 1 gene products. Furthermore, ilv 1 mutants have been isolated in three different structural domains indicating that the ilv 1 gene may contain a functional intervening sequence specific for one of the two gene products.
D001483:Base Sequence; D004271:DNA, Fungal / Q000235:genetics; D005796:Genes; D005809:Genes, Regulator; D007532:Isoleucine / Q000235:genetics*; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D013913:Threonine Dehydratase / Q000235:genetics; D014633:Valine / Q000235:genetics*
D004271:DNA, Fungal; D007532:Isoleucine; D013913:Threonine Dehydratase; D014633:Valine