Inhibition of the active E-rosette-forming T lymphocytes by a mesenchyme associated antigen.
Using the active E-rosette method, we have obtained evidence for the inhibition of their formation by a mesenchyme associated antigen (MAA) which was found in human tumors. After incubation of lymphocytes with MAA, the active E-rosette percentage in 28 healthy donors fell from 22.4 +/- 3.5 to 11.3 +/- 2.8. This inhibition was studied for different concentrations of MAA and remained significant for 22.5 microgram/ml. In vivo implication of this inhibition is discussed.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D006801:Humans; D007668:Kidney / Q000276:immunology; D008099:Liver / Q000276:immunology; D051381:Rats; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D000951:Antigens, Neoplasm