Corynebacterium liquefaciens-induced suppressor T cells in graft-versus-host reaction.
The effect of the spleen cells and thymus cells from Corynebacterium liquefaciens-treated (C57BL/6 x BALB/c)F1 hybrid mice on graft-versus-host (GVH) reaction, initiated in the parental to newborn F1 hybrid strain combination, was studied by using Simonsen's spleen assay. The combined inocula of 5 x 10(6) normal BALB/c spleen cells and 50 x 10(6) spleen cells from F1 mice that had been given i.v. injections of 1 mg of C. liquefaciens yielded a significantly smaller spleen index than did 5 x 10(6) BALB/c spleen cells alone. This suppressive function of C. liquefaciens-treated F1 spleen cells was more potent in phagocyte-depleted and T cell-enriched cell fractions. Thymus cells from C. liquefaciens-treated F1 mice also suppressed GVH reaction. The results suggest that C. liquefaciens can induce the suppressor T cells.
D000818:Animals; D003352:Corynebacterium / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005260:Female; D006087:Graft vs Host Reaction; D006824:Hybridization, Genetic; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000637:transplantation; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000637:transplantation; D014181:Transplantation Immunology; D014184:Transplantation, Homologous