title: Cytotoxic T lymphocytes directed against HLA-Bw 35-linked target determinants show differences in sensitivity toward antibiotics during sensitization period.
abstract: Recently, we demonstrated that the outcome of human CML was influenced by the presence of antibiotics in the culture medium, In earlier studies we had found that cytotoxic T lymphocytes could recognize HLA-Bw 35-linked target determinants. These so-called Bw35 a and b determinants showed mendelian segregation. We describe in this article a difference between the Bw35 a and b cytotoxic T cells in their sensitivity toward antibiotics. The lysis against the Bw35 b cytotoxic determinant was not influenced by either the presence or the absence of antibiotics during the sensitization period, whereas the lysis against the Bw35 a cytotoxic determinant was drastically diminished when the effector cells were cultured in the absence of antibiotics during the sensitization period.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D015235:HLA-B Antigens; D006650:Histocompatibility Testing; D006801:Humans; D007114:Immunization; D008213:Lymphocyte Activation / Q000187:drug effects; D010375:Pedigree; D010406:Penicillins / Q000494:pharmacology; D013307:Streptomycin / Q000494:pharmacology; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*
chemical_list: D000900:Anti-Bacterial Agents; D006680:HLA Antigens; D015235:HLA-B Antigens; D010406:Penicillins; D013307:Streptomycin