title: [Hyperandrogenism due to adrenal enzyme deficiency: possibility of pregnancy. Five cases (author's transl)].
abstract: Five women suffering from hyperandrogenism due to adrenal enzyme deficiency, with various clinical symptoms and discovered at a more or less early stage, had a total of 7 pregnancies. 21-hydroxylase was deficient in three, and 11-beta-hydroxylase in two women. The pregnancies occured 6 months to 10 years after corticosteroid treatment was started in four cases, and after it was discontinued in a case of partial deficiency in 11-beta-hydroxylase. Four women delivered on term, two of them normally and two by caesarean section. The fifth woman delivered prematurely on the 33rd week. Two pregnancies were interrupted either spontaneously or voluntarily. None of the newborn babies (three girls and two boys) showed any abnormality. With the exception of the premature girl, their weight was normal. The oldest of the girls had a normal puberty at the age of thirteen.
mesh_terms: D000307:Adrenal Gland Diseases / Q000188:drug therapy / Q000201:enzymology*; D000312:Adrenal Hyperplasia, Congenital; D000328:Adult; D000728:Androgens / Q000378:metabolism*; D036861:Delivery, Obstetric; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010053:Ovary / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications; D013250:Steroid Hydroxylases / Q000172:deficiency*; D014770:Virilism / Q000209:etiology
chemical_list: D000728:Androgens; D005938:Glucocorticoids; D013250:Steroid Hydroxylases
vernacular_title: Hyperandrogénie par déficit enzymatique surrénalien: possibilité de grossesse. Cinq observations.