Immune modulation by epidermal cell products: possible role of ETAF in inflammatory and neoplastic skin diseases.
Recent studies have indicated that the epidermis plays an important role in the modulation of immunologic reactions. The factors involved in these processes include not only Langerhans cells but also keratinocyte products. One of these products, ETAF (Epidermal cell derived Thymocyte Activating Factor), which is similar to the macrophage derived product interleukin 1 (IL-1), is reviewed. Speculations as to its possible role in skin diseases are presented.
D000941:Antigens / Q000032:analysis; D003872:Dermatitis / Q000276:immunology*; D004817:Epidermis / Q000276:immunology*; D006801:Humans; D007376:Interleukin-2 / Q000502:physiology*; D008232:Lymphoproliferative Disorders / Q000276:immunology; D012878:Skin Neoplasms / Q000276:immunology*
D000941:Antigens; D007376:Interleukin-2