Cimetidine does not stimulate human T lymphocyte functions in vitro.
Cimetidine, an H2-receptor antagonist had no immunoproliferative or immunostimulative effect on in vitro T cell functions of normal human peripheral blood lymphocytes. This was shown by adding Cimetidine to mitogen, alloantigen and xenoantigen-stimulated cultures. Generation of helper and cytotoxic T cells was not modified in a full kinetic experiment. These data failed to confirm previous reports showing an increase of cell-mediated immunity under Cimetidine therapy.
D002478:Cells, Cultured; D002857:Chromium / Q000378:metabolism; D002927:Cimetidine / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D010835:Phytohemagglutinins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects*; D013997:Time Factors
D006146:Guanidines; D010835:Phytohemagglutinins; D002857:Chromium; D002927:Cimetidine