A murine B-cell lymphoma induced by Gross virus.
A B-lymphocyte tumor (MLB-MN line) was induced by Gross murine leukemia virus in Slc:ddY mice, successively passaged in normal adult mice, and adapted to tissue culture. The surface marker expression of MLB-MN was examined and found to include several markers that are known to occur in normal B-lymphocytes. The cells bore surface immunoglobulin M, detected by indirect immunofluorescence staining, and Fc receptors and complement receptors, detected by rosette formation. Thy 1 antigen and secretion of immunoglobulin were lacking. These results have led us to postulate that the origin of the MLB-MN tumor was a late differentiation stage of the B-lymphocyte.
D000406:AKR murine leukemia virus; D000011:Abelson murine leukemia virus; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002460:Cell Line; D002462:Cell Membrane / Q000032:analysis / Q000276:immunology; D007075:Immunoglobulin M / Q000032:analysis; D008223:Lymphoma / Q000473:pathology*; D051379:Mice; D009374:Neoplasms, Experimental / Q000473:pathology; D011951:Receptors, Complement / Q000032:analysis; D011961:Receptors, Fc / Q000032:analysis
D007075:Immunoglobulin M; D011951:Receptors, Complement; D011961:Receptors, Fc