Effect of iodide on glucose, N-acetylglucosamine and leucine incorporation into acid-insoluble fraction of pig thyroid proteins in vitro.
The effect of KI on D-[1-14C]glucose and N-acetyl-D-[1-14C]glucosamine incorporation into thyroid proteins was studied in vitro. It was found that KI in a concentration of 0.1 mmol 1-1 had no effect on the incorporation of the sugars under study. However, under the same experimental conditions KI inhibited L-[1-14C]leucine incorporation into proteins. It is suggested that KI, appropriate concentrations, inhibits the synthesis of peptide chains but has no effect on the incorporation of sugars into proteins.
D000117:Acetylglucosamine / Q000378:metabolism*; D000818:Animals; D005944:Glucosamine / Q000031:analogs & derivatives*; D005947:Glucose / Q000378:metabolism*; D066298:In Vitro Techniques; D007930:Leucine / Q000378:metabolism*; D011193:Potassium Iodide / Q000494:pharmacology*; D014176:Protein Biosynthesis; D013552:Swine; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism*
D011193:Potassium Iodide; D007930:Leucine; D005947:Glucose; D005944:Glucosamine; D000117:Acetylglucosamine