Photocontact allergy to benzocaine.
A photodermatitis developed in two patients after the use of commercial sunscreens and a topical anesthetic lotion containing benzocaine. Photopatch testing indicated the presence of photocontact allergy to benzocaine. One patient had a positive photopatch test to a commercial glyceryl para-aminobenzoic acid (PABA) preparation that was heavily contaminated with benzocaine, but not to a benzocaine-free sample of glyceryl PABA. Benzocaine failed to produce phototoxic reactions in normal volunteers. Efforts to induce photocontact allergy in guinea pigs were unsuccessful.
D010129:4-Aminobenzoic Acid / Q000009:adverse effects; D000328:Adult; D000818:Animals; D001566:Benzocaine / Q000009:adverse effects*; D004340:Drug Contamination; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D010328:Patch Tests; D010787:Photosensitivity Disorders / Q000139:chemically induced*
D010129:4-Aminobenzoic Acid; D001566:Benzocaine