Cytotoxic effects of protease inhibitors on human cells. 1. High sensitivity of xeroderma pigmentosum cells to antipain.
Antipain had little effect on UV-survival and UV-induced sister chromatid exchanges in normal and xeroderma pigmentosum (XP) cells, suggesting that it may not affect DNA repair. Antipain itself produced a small, but significant, amount of sister chromatid exchanges. XP cells showed very high sensitivity to the cytotoxic effect of antipain, but an SV40-transformed XP cell strain did not demonstrate high sensitivity.
D000293:Adolescent; D000328:Adult; D000976:Antipain / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002472:Cell Transformation, Viral / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004260:DNA Repair / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D007223:Infant; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects / Q000528:radiation effects; D012867:Skin; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000473:pathology*
D009842:Oligopeptides; D000976:Antipain