Prospective controlled trial of cryoprecipitated plasma, plasma protein fraction and serum albumin solution for kidney preservation.
A controlled prospective study was conducted to compare the results of kidney preservation and transplantation in regard to the type of perfusate used for perfusion preservation. Cryoprecipitated plasma, plasma protein fraction and serum albumin solution were used as perfusate. Between February 1979 and July 1980, 176 kidneys were preserved by one of these perfusates and transplanted. There was no statistically significant difference in the donor and recipient status, perfusion characteristics or graft and patient survival among the three groups. Synthetic perfusates are an acceptable alternative to cryoprecipitated plasma for perfusion preservation of cadaver kidneys.
D000328:Adult; D001798:Blood Proteins / Q000627:therapeutic use*; D002102:Cadaver; D002986:Clinical Trials as Topic; D003451:Cryoprotective Agents / Q000008:administration & dosage*; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D009926:Organ Preservation / Q000379:methods*; D010477:Perfusion; D010952:Plasma Substitutes / Q000627:therapeutic use*; D011310:Preservatives, Pharmaceutical / Q000008:administration & dosage; D011446:Prospective Studies; D012709:Serum Albumin / Q000008:administration & dosage*; D000075462:Serum Albumin, Human; D012712:Serum Globulins; D012996:Solutions; D014021:Tissue Preservation / Q000379:methods*; D014184:Transplantation, Homologous
D001798:Blood Proteins; D003451:Cryoprotective Agents; D010952:Plasma Substitutes; D011310:Preservatives, Pharmaceutical; D012709:Serum Albumin; D012712:Serum Globulins; D012996:Solutions; C008930:plasma protein fraction; D000075462:Serum Albumin, Human