[Central and peripheral catecholamines in combined cerebral and renal hypertension].
The present study was carried out on male rats, using three models of experimental hypertension: cerebroischemic, single clamp bilateral and combined, induced by ischemia of the brain and one of the kidneys. The authors determined DA, NA, A in the hypothalamus and medulla oblongata as well as A, NA in plasma in view of the connection between CA (catecholamine) and cerebral and renal renin-angiotensin system (RAS). In rats with cerebral hypertension there was activation of noradrenergic neurons in the hypothalamus and medulla oblongata. There were no changes in the content of A. In rats with renal hypertension the activation of noradrenergic neurons in the hypothalamus was due to exhaustion of NA stores with normal amount of DA, but still the adrenergic neurons were activated. In rats with combined hypertension there was lowering of NA and DA in the hypothalamus, but A was not altered, e.g. the changes, observed singly and in cerebral and renal hypertension were combined. In the three forms of hypertension there were similar changes in medulla oblongata (reduced DA, increased NA and unaltered) and in plasma (A without significant changes). The changes in the level of CA in cerebral and combined hypertension could be explained by a change in the sinocarotid reflex, but in the renal-with the increased level of plasma angiotensin. The authors suggest that the connection between cerebral CA and cerebral RAS is not a direct one and RAS is not directly involved in the inverse interrelationships between cerebral and renal RAS.
D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure; D002545:Brain Ischemia / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D006977:Hypertension, Renal / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism; D051381:Rats; D012083:Renin / Q000378:metabolism
D002395:Catecholamines; D000804:Angiotensin II; D012083:Renin
Tsentralni i periferni katekholamini pri kombinirana mozŭchna i bŭbrechna khipertoniia.