title: Distribution of glucose incorporated into macromolecular material by treponema pallidum.
abstract: Treponema pallidum was observed to incorporate glucose carbons into lipids, ribonucleic acid, deoxyribonucleic acid, and protein. Only the glycerol portions of phosphatidylcholine and phosphatidylglycerol contained glucose-derived carbons. Incorporation of exogenous choline into phosphatidylcholine was detected. Glucose was incorporated into only the pentoses of nucleic acids. About 50% of the glucose incorporated into protein was present in only one amino acid, aspartate. Evidence suggests that aspartate synthesis could follow the conversion of phosphoenolpyruvate to oxalacetic acid by a guanosine 5'-diphosphate-dependent phosphoenolpyruvate carboxykinase.
mesh_terms: D000818:Animals; D005947:Glucose / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism; D008055:Lipids / Q000096:biosynthesis; D009696:Nucleic Acids / Q000096:biosynthesis; D010071:Oxaloacetates / Q000378:metabolism; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000378:metabolism; D014176:Protein Biosynthesis; D014210:Treponema pallidum / Q000378:metabolism*
chemical_list: D008055:Lipids; D009696:Nucleic Acids; D010071:Oxaloacetates; D010729:Phosphoenolpyruvate Carboxykinase (GTP); D007930:Leucine; D005947:Glucose