Effect of cyclosporin A upon second-set rejection of rat renal allografts.
With the use of a DA to LEW rat renal allograft model, the ability of cyclosporin A to influence a second-set rejection was investigated. Sensitization of LEW rats was accomplished by performing DA to LEW skin grafts 4 to 5 weeks before kidney allografting. Cyclosporin A was given to sensitized rats in doses of 10 or 25 mg/kg/day for 14 days from the time of renal transplantation. Neither dose was nearly as effective in prolonging kidney graft survival in sensitized rats as the 10 mg/kg/day dose was in prolonging kidney graft survival in unsensitized rats. In the 25 mg/kg/day dose, cyclosporin A was capable of suppressing antibody formation to the graft in sensitized recipients despite the presence of donor-specific antibodies at the time of renal transplantation. The 10 mg/kg/day dose of cyclosporin A did not, however, suppress antibody formation after renal transplantation in sensitized recipients. In both sensitized and unsensitized rats cyclosporin A was effective in ameliorating the histological findings of arterial fibrinoid necrosis and glomerular necrosis in the renal allografts. In neither sensitized nor unsensitized rats did cyclosporin A effect the mononuclear cell infiltration of the renal allograft.
D000818:Animals; D000961:Antilymphocyte Serum / Q000032:analysis; D003524:Cyclosporins; D006084:Graft Rejection / Q000187:drug effects*; D007114:Immunization; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation; D008297:Male; D010456:Peptides, Cyclic / Q000494:pharmacology*; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D016038:Skin Transplantation; D014181:Transplantation Immunology; D014184:Transplantation, Homologous; D014508:Urea / Q000097:blood
D000961:Antilymphocyte Serum; D003524:Cyclosporins; D010456:Peptides, Cyclic; D014508:Urea