Mutagenicity of nifurtimox in Escherichia coli.
The effects of nifurtimox, a nitrofuran derivative, on killing and mutation induction in 3 Escherichia coli strains having different DNA-repair systems for UV lesion were studied and compared with the effects of furylfuramide. Nifurtimox induces mutations at a high frequency in both Hs3OR (uvrA-) and H/r30R (radiation-resistant), although no significant killing effect is detected with Hs30R. No significantly induced mutation frequency could be detected with NG30 (recA-), which is very sensitive to killing by nifurtimox. The characteristics of lesions of DNA induced by nifurtimox and the mechanism of mutation induction in Hs30R are discussed.
D004260:DNA Repair; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D005668:Furylfuramide / Q000494:pharmacology; D005838:Genotype; D009153:Mutagens / Q000494:pharmacology*; D009547:Nifurtimox / Q000494:pharmacology*; D009581:Nitrofurans / Q000494:pharmacology*
D009153:Mutagens; D009581:Nitrofurans; D005668:Furylfuramide; D009547:Nifurtimox