The biocompatibility of dental implant materials measured in an animal model.
The biocompatibility of two implant materials, vitallium and poly-methyl methacrylate (PMMA), was evaluated in an animal model in which bone formation and resorption are independent of each other. Neither material accelerated resorption, but formation was inhibited 12% by vitallium and 38% by PMMA. When three PMMA preparations varying in monomer content were tested, the data exhibited a dose-response relation, suggesting that inhibition of bone formation was due to the presence of residual monomer.
D000818:Animals; D001672:Biocompatible Materials; D001862:Bone Resorption / Q000503:physiopathology; D016025:Bone Transplantation; D001842:Bone and Bones / Q000033:anatomy & histology; D002858:Chromium Alloys / Q000494:pharmacology*; D003757:Dental Implantation; D008768:Methylmethacrylates / Q000494:pharmacology*; D009132:Muscles / Q000601:surgery; D010012:Osteogenesis / Q000187:drug effects; D011817:Rabbits; D014182:Transplantation, Autologous; D014800:Vitallium / Q000494:pharmacology*
D001672:Biocompatible Materials; D002858:Chromium Alloys; D008768:Methylmethacrylates; D014800:Vitallium