A model system for studying initial events in atherosclerosis.
A model system has been developed which employs the central artery of the rabbit ear, and allows for the study of 1) ultra-structural changes in the arterial endothelium and 2) formation and release of prostacyclin and thromboxane from the arteries in situ. Use of the model should be helpful in evaluating the initial events in atherosclerosis. Both prostacyclin and thromboxane (detected by radioimmunoassay) were formed by arteries in situ in response to infusion of sodium arachidonate.
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology; D001161:Arteriosclerosis / Q000503:physiopathology*; D004195:Disease Models, Animal; D004423:Ear / Q000098:blood supply; D004727:Endothelium / Q000648:ultrastructure; D011464:Epoprostenol / Q000096:biosynthesis; D008297:Male; D011817:Rabbits; D013929:Thromboxane B2 / Q000096:biosynthesis
D001095:Arachidonic Acids; D013929:Thromboxane B2; D011464:Epoprostenol