[Effect of antigen dose on the course of experimental mycogenic sensitization].
Guinea pigs were sensitized with different doses of homogenous Candida albicans cells introduced by 3 subcutaneous injections at intervals of 2--3 days. The allergic rearrangement in the animal body thus induced was found to depend on the dose of the preparation injected into the animals: the lowest dose of the antigen (0.1 mg) induced immediate allergic reaction, and doses 5--10 times higher induced double rearrangement i.e. immediate and delayed reactions.
D000818:Animals; D000946:Antigens, Fungal / Q000008:administration & dosage*; D001491:Basophils / Q000648:ultrastructure; D002176:Candida albicans / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D006168:Guinea Pigs; D006388:Hemagglutinins / Q000032:analysis; D006967:Hypersensitivity / Q000209:etiology*; D006968:Hypersensitivity, Delayed / Q000209:etiology; D006969:Hypersensitivity, Immediate / Q000209:etiology; D007111:Immunity, Cellular; D007518:Isoantibodies / Q000032:analysis; D007961:Leukocyte Migration-Inhibitory Factors / Q000032:analysis; D012882:Skin Tests
D000946:Antigens, Fungal; D006388:Hemagglutinins; D007518:Isoantibodies; D007961:Leukocyte Migration-Inhibitory Factors
Vliianie dozy antigena na techenie éksperimental'noĭ mikogennoĭ sensibilizatsii.