The E. coli beta-lactamase attenuator mediates growth rate-dependent regulation.
We have identified a new control or attenuator region in the chromosomal beta-lactamase operon of Escherichia coli. A single base alteration within its attenuator led to a loss in the cell's ability to coordinate its content of beta-lactamase with growth rate. We suggest a mechanism through which this mode of regulation operates.
D001483:Base Sequence; D003001:Cloning, Molecular; D004926:Escherichia coli / Q000235:genetics* / Q000254:growth & development; D005786:Gene Expression Regulation; D005809:Genes, Regulator; D008957:Models, Genetic; D009154:Mutation; D009876:Operon; D010957:Plasmids; D014176:Protein Biosynthesis; D014158:Transcription, Genetic; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
D001618:beta-Lactamases