Bacterial endotoxin and the generation of suppressor T cells following thermal injury.
Patients with several thermal injuries often display an impaired cell-mediated immune response. Clinically, this expressed as an increased susceptibility to infection and, occasionally, as a decreased ability to reject unmatched allograft skin. Experimentally, patient serum is suppressive to the PHA response of normal human lymphocytes, which we have found to be mediated through B cell participation in the generation of suppressor T cells. We herein document the ability of bacterial endotoxin to produce these effects, both in vivo and in vitro.
D000328:Adult; D001427:Bacterial Toxins / Q000276:immunology*; D002056:Burns / Q000276:immunology*; D002478:Cells, Cultured; D004731:Endotoxins / Q000276:immunology*; D004926:Escherichia coli; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008070:Lipopolysaccharides / Q000276:immunology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000494:pharmacology; D018805:Sepsis / Q000209:etiology; D013601:T-Lymphocytes / Q000276:immunology*
D001427:Bacterial Toxins; D004731:Endotoxins; D008070:Lipopolysaccharides; D010835:Phytohemagglutinins