The procoagulant activity of leukocytes pretreated with radiodetoxified endotoxin.
Rabbits were treated with Escherichia coli 089 endotoxin detoxified by ionizing irradiation (60 Co-gamma). The leukocytes (PMNs in 90%) obtained from rabbits that had been treated with the mother endotoxin elicited a well defined, those obtained from rabbits pretreated with detoxified endotoxin elicited a less pronounced, procoagulant activity. It is suggested that the procoagulant effect may play a part in the mechanism of the local Shwartzman phenomenon.
D000818:Animals; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000378:metabolism*; D004731:Endotoxins / Q000494:pharmacology* / Q000528:radiation effects / Q000633:toxicity; D004926:Escherichia coli; D005720:Gamma Rays; D008297:Male; D009504:Neutrophils / Q000502:physiology*; D011817:Rabbits
D001779:Blood Coagulation Factors; D004731:Endotoxins