title: Fatty acids, fibrinogen and blood flow: a general mechanism for hyperfibrinogenemia and its pathologic consequences.
abstract: Plasma fibrinogen is elevated in various stressful states and conditions in which active mobilization of free fatty acids (FFA) occurs. Reduction of plasma FFA by an assortment of hypolipidemic drugs is consistently followed by a decrease in the accompanying hyperfibrinogenemia. A direct link between FFA and fibrinogen has been demonstrated in animals, and in experiments employing incubated liver slices. Based on these clinical and experimental observations, we postulate that hepatic fibrinogen synthesis is stimulated by FFA. Since fibrinogen is a major determinant of whole blood viscosity, erythrocyte aggregation, and sludging of red cells in terminal and pre-terminal blood vessels, we propose that microcirculatory blood flow may be impaired in the presence of chronically elevated plasma FFA levls. Consequently, hypolipidemic drugs may be effective in prevention of circulatory complications associated with FFA-induced hyperfibrinogenemia.
mesh_terms: D001783:Blood Flow Velocity; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology; D008053:Lipid Mobilization; D012212:Rheology; D012709:Serum Albumin / Q000378:metabolism; D013315:Stress, Psychological
chemical_list: D005230:Fatty Acids, Nonesterified; D000960:Hypolipidemic Agents; D012709:Serum Albumin; D005340:Fibrinogen