Studies on the detection of chemical carcinogens using a mammalian cell transformation assay. A correlated study of BHK cell transformation and bacterial mutagenicity.
Transformation of BHK 21/Cl 13 cells was used as a test system to detect the carcinogenic potential of Busulfan (Myleran). To correlate carcinogenicity of the compound with its mutagenic activity, bacterial mutagenicity was demonstrated in the Salmonella/microsome test.
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D006224:Cricetinae; D007668:Kidney; D008647:Mesocricetus; D009152:Mutagenicity Tests; D012486:Salmonella typhimurium / Q000235:genetics
D002273:Carcinogens