[Effect of ethmozine and its diethylamino analog on the slow incurrent and excurrent ion flows of cardiac atrial fibers].
The effects of ethmozine (2 X 10(-5) g/ml) and diethylamine derivative of ethmozine (DAD of ethmozine) (2 X 10(-5) g/ml) on slow inward and outward currents were investigated by means of the voltage clamp method in frog auricular trabeculae. Ethmozine increased the maximal value of the slow inward current by 62 +/- 11% (n = 5) while DAD of ethmozine decreased it by 54 +/- 17% (n = 3). The control value of the slow inward current was restored after 30 min of wash out. Ethmozine and DAD of ethmozine had no significant effect on steady-state outward current.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D006325:Heart Atria; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D016293:Moricizine / Q000031:analogs & derivatives; D009025:Morpholines / Q000494:pharmacology; D010640:Phenothiazines / Q000494:pharmacology*; D011892:Rana catesbeiana; D011895:Rana ridibunda; D012964:Sodium / Q000378:metabolism
D000889:Anti-Arrhythmia Agents; D009025:Morpholines; D010640:Phenothiazines; C027240:diethylamino-ethmozine; D016293:Moricizine; D012964:Sodium; D002118:Calcium
Vliianie étomozina i ego diétilaminovogo analoga na medlennyĭ vkhodiashchiĭ i vykhodiashchiĭ ionnye toki predserdnykh volokon liagushki.