title: Mutagenicity of methylated fluorenes and benzofluorenes.
abstract: Methylated fluorenes were assayed for mutagenic activity towards Salmonella typhimurium TA98 and TA100. None of these methylfluorenes were mutagenic in the absence of metabolic activation. In the presence of 9000 X g supernatant from Aroclor-induced rats, 9-methylfluorene and 1,9-dimethylfluorene were active towards TA98 and TA100. The structural requirement for mutagenic activity within this series was the presence of a single methyl substituent at the 9-position. Enhanced mutagenic activity was also observed for benzofluorenes similarly methylated at their benzylic positions.
mesh_terms: D000818:Animals; D001711:Biotransformation; D005449:Fluorenes / Q000378:metabolism / Q000494:pharmacology*; D008745:Methylation; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics; D013329:Structure-Activity Relationship
chemical_list: D005449:Fluorenes; D009153:Mutagens; C030637:1,9-dimethylfluorene; C030636:9-methylfluorene