title: [Effect of levorin on incorporation of individual amino acids into proteins of membranes, ribosomes and cell sap of Candida albicans].
abstract: The effect of levorin on incorporation of labelled amino acids into the protoplasts and proteins of C. albicans depended on the ionic composition of the medium and on the amino acid tested. In a potassium-enriched medium the predominant effect of levorin on [14C] alanine transport into the protoplasts was decreased, while in case of [14C] leucine transport it was completely eliminated. The incorporation of [14C] alanine into the proteins of ribosomes and cell juice was inhibited by the antibiotic in a greater degree as compared to the membrane proteins, the difference in the rate being more pronounced in a sodium-enriched medium. The incorporation of [14C] leucine was inhibited in all protein fractions in the same degree, which was observed only in a sodium-enriched medium.
mesh_terms: D000409:Alanine / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D000935:Antifungal Agents / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D002174:Candicidin / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D005656:Fungal Proteins / Q000096:biosynthesis*; D007930:Leucine / Q000378:metabolism; D008565:Membrane Proteins / Q000096:biosynthesis*; D012269:Ribosomal Proteins / Q000096:biosynthesis*; D012270:Ribosomes / Q000378:metabolism
chemical_list: D000596:Amino Acids; D000935:Antifungal Agents; D005656:Fungal Proteins; D008565:Membrane Proteins; D012269:Ribosomal Proteins; D002174:Candicidin; D007930:Leucine; D000409:Alanine
vernacular_title: Deĭstvie levorina na vkliuchenie individual'nykh aminokislot v belki membran, ribosom i kletochnogo soka Candida albicans.