title: Cross-reactions between the Tamm-Horsfall glycoprotein and Escherichia coli.
abstract: Weak cross-reactions were demonstrated between the Tamm-Horsfall (TH) glycoprotein and antigens in the supernatants of boiled Escherichia coli R1-R4 strains using an inhibitory ELISA system. No cross-reactions could be determined between the purified R1-R4 lipopolysaccharides and the TH protein. Neither could any inhibition be recorded after trypsin treatment, indicating that the cross-reacting substance is protein in nature. The cross-reactions were verified by immunoprecipitation techniques. The biological relevance of the cross-reaction between E. coli and the TH protein particularly as an event inducing the formation of autoantibodies to the TH protein is discussed.
mesh_terms: D000942:Antigens, Bacterial / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D004926:Escherichia coli / Q000276:immunology*; D006801:Humans; D009088:Mucoproteins / Q000276:immunology*; D011233:Precipitin Tests; D058949:Uromodulin
chemical_list: D000942:Antigens, Bacterial; D001323:Autoantibodies; D009088:Mucoproteins; C548612:UMOD protein, human; D058949:Uromodulin