Asystole complicating physostigmine treatment of tricyclic antidepressant overdose.
Physostigmine is a commonly used therapy for the anticholinergic manifestations of tricyclic antidepressant (TCA) overdose. We describe two patients with TCA toxicity who developed asystole following the administration of physostigmine to treat seizures.
D000328:Adult; D000639:Amitriptyline / Q000506:poisoning; D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D001919:Bradycardia / Q000139:chemically induced; D004562:Electrocardiography; D006323:Heart Arrest / Q000139:chemically induced*; D006801:Humans; D007099:Imipramine / Q000506:poisoning; D008297:Male; D010276:Parasympatholytics / Q000009:adverse effects; D010830:Physostigmine / Q000009:adverse effects*; D011433:Propranolol / Q000506:poisoning
D000929:Antidepressive Agents, Tricyclic; D010276:Parasympatholytics; D000639:Amitriptyline; D010830:Physostigmine; D011433:Propranolol; D007099:Imipramine