[Fenclofenac in the treatment of rheumatoid arthritis (author's transl)].
The effectiveness of fenclofenac in the treatment of rheumatoid arthritis was compared in a crossover double-blind study of 30 patients with that of indometacin over a period of two weeks. The therapeutic effectiveness of fenclofenac, at a daily dose of 900 mg, was comparable to that of indometacin, at a daily dose of 100 mg. Side effects were less common with fenclofenac than indometacin, especially with respect to gastro-intestinal ones. On questioning more patients preferred fenclofenac, and its use is therefore recommended for patients with actual or potential gastro-intestinal problems.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010648:Phenylacetates / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D010648:Phenylacetates; D007213:Indomethacin; C012970:fenclofenac
Klinische Erfahrungen mit Fenclofenac bei rheumatoider Arthritis.