Mutagens in extracts of human gastric mucosa.
Extracts of mucosa from 53 stomachs were tested for mutagenicity with the use of Salmonella typhimurium strains TA98 and TA100. Mutagenic activity was observed in nonneoplastic mucosa from seven stomachs with S. typhimurium strain TA98 without the S-. mix (a rat liver microsomal enzyme preparation) and in three stomachs with TA100 without S-. mix. All of the TA98 mutagenic samples were derived from stomachs showing evidence of intestinal metaplasia. The exception was an extract of corpus mucosa that was mutagenic with strain TA100. "Transnitrosoase" activity was found in 12 of 53 samples, all of which showed TA98 mutagenicity. Whether the presence of mutagens and transnitrosoase activity causes intestinal metaplasia or results from it is uncertain.
D005753:Gastric Mucosa / Q000032:analysis / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D007422:Intestines / Q000473:pathology; D008679:Metaplasia / Q000201:enzymology*; D009153:Mutagens / Q000032:analysis*; D019884:Nitrogenous Group Transferases; D011230:Precancerous Conditions / Q000378:metabolism; D012486:Salmonella typhimurium / Q000235:genetics; D013274:Stomach Neoplasms / Q000473:pathology; D014166:Transferases / Q000378:metabolism*
D009153:Mutagens; D014166:Transferases; D019884:Nitrogenous Group Transferases; C026468:nitrosotransferase