title: Effect of positive-end-expiratory-pressure on right ventricular output in lambs with hyaline membrane disease.
abstract: Right and left ventricular outputs, pulmonary and systemic blood flows, and blood flows in both directions through the ductus arteriosus were measured before and during positive-end-expiratory-pressure in 5 premature lambs with induced hyaline membrane disease. During positive-end-expiratory-pressure, right ventricular output increased in all lambs without any significant change in left ventricular output or pulmonary vascular resistance. Left-to-right ductus flow decreased in lambs which initially had large left-to-right ductus shunts. significant right-to-left ductus flow did not occur before or during positive-end-expiratory-pressure.
mesh_terms: D000818:Animals; D002302:Cardiac Output; D004373:Ductus Arteriosus / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D006819:Hyaline Membrane Disease / Q000503:physiopathology* / Q000628:therapy; D007231:Infant, Newborn; D007385:Intermittent Positive-Pressure Ventilation / Q000379:methods*; D011175:Positive-Pressure Respiration / Q000379:methods*; D012756:Sheep; D014655:Vascular Resistance