The antigenicity of synchronous cancers of the colon and rectum.
Immuno-reactivity to tumor extracts in patients with colorectal cancer was evaluated by the direct leukocyte migration inhibition assay. Hypertonic potassium chloride extracts were prepared from a group of synchronous colorectal cancers and from single colorectal cancers. Both groups of extracts were tested in patients with single colorectal cancers. All patients were tested preoperatively, none were previously treated, and none had distant metastases. Synchronous extracts showed no significant migration inhibition in allogeneic assays. Single colorectal cancers showed highly significant inhibition to autologous extracts only and not to allogeneic extracts. These data support the contention colorectal cancers are antigenically dissimilar.
D000368:Aged; D000951:Antigens, Neoplasm / Q000276:immunology*; D002277:Carcinoma / Q000276:immunology*; D003110:Colonic Neoplasms / Q000150:complications / Q000276:immunology*; D005260:Female; D006801:Humans; D007417:Intestinal Polyps / Q000276:immunology; D007961:Leukocyte Migration-Inhibitory Factors / Q000276:immunology; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000276:immunology*; D012004:Rectal Neoplasms / Q000150:complications / Q000276:immunology*
D000951:Antigens, Neoplasm; D007961:Leukocyte Migration-Inhibitory Factors