Mutations and cell transformation with 2-azido-9-fluorenone oxime.
When photolyzed in situ for as little as 15 s 2-azido-9-fluorenone oxime causes Type II and Type III transformation in C3H 10T 1/2 CL8 cells. In the yeast strain Saccharomyces cerevisiae D-7, simple reversions and gene conversions occurred and also mitotic crossing over, to a lesser extent, but no mitochondril "petite" mutants occurred. No mutations or transformations were induced in the dark or by the light itself.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D003434:Crossing Over, Genetic / Q000187:drug effects; D005449:Fluorenes / Q000494:pharmacology*; D008027:Light; D051379:Mice; D009154:Mutation / Q000187:drug effects*; D010782:Photolysis; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics
D005449:Fluorenes; C026021:2-azido-9-fluorenone oxime