title: Reduced responses of renin release to three different stimuli in essential hypertensive patients of stage II (WHO stage classification).
abstract: The responses of renin release to three different stimuli, such as 1) head-up tilt, 2) administration of loop diuretics(bumetanide) and 3) low sodium diet + administration of bumetanide + ambulation were examined in essential hypertensive patients and normotensive subjects. Essential hypertensive patients were classified as stage I and II according to WHO stage classification. Groups studied were age-matched. The responses of renin release to three stimuli did not significantly differ in normotensive subjects (n = 13, 42 +/- 2(SEM) years old) and essential hypertensive patients of stage I (n = 15, 44 +/- 2). However, essential hypertensive patients of stage II (n = 20, 44 +/- 1) showed significantly lower responses of renin release to all three stimuli than essential hypertensive patients of stage I and normotensive subjects. The results suggest that the suppression of renin release is related in part to the development of hypertension.
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002034:Bumetanide / Q000494:pharmacology; D003864:Depression, Chemical; D004039:Diet, Sodium-Restricted; D005260:Female; D006801:Humans; D006973:Hypertension / Q000145:classification / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011187:Posture; D012083:Renin / Q000097:blood / Q000378:metabolism*; D014944:World Health Organization; D000092502:Renin Inhibitors
chemical_list: D002034:Bumetanide; D012083:Renin; D000092502:Renin Inhibitors