Increased prostacyclin synthesizing activity in human ripening uterine cervix.
Homogenate of human uterine cervix at delivery were incubated with radioactive arachidonic acid. A major metabolite (conversion rate, approx. 20%) was identified with 6-ketoprostaglandin F1 alpha, a metabolite of prostacyclin. The 6-ketoprostaglandin F1 alpha production in the ripening cervix was more than 6 times per wet weight and 37 times per DNA as much as that in the non-pregnant cervix.
D015121:6-Ketoprostaglandin F1 alpha; D001095:Arachidonic Acids / Q000378:metabolism; D002584:Cervix Uteri / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D011464:Epoprostenol / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007743:Labor, Obstetric; D011247:Pregnancy; D011453:Prostaglandins / Q000096:biosynthesis*; D011460:Prostaglandins F / Q000096:biosynthesis; D013929:Thromboxane B2 / Q000096:biosynthesis
D001095:Arachidonic Acids; D011453:Prostaglandins; D011460:Prostaglandins F; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D004247:DNA; D011464:Epoprostenol