Nature of streptomycin resistance in enterobacteria from faeces of streptomycin-treated patients in Egypt.
Streptomycin-resistant enterobacteria were isolated from the faeces of 31 out of 35 patients under streptomycin therapy, in the University Hospital of Alexandria. The isolated bacteria were 26 Escherichia coli, 3 Klebsiella pneumoniae and 2 Enterobacter cloacae. Their resistance patterns have shown that 80% had multiple antibiotic resistance. The MIC of streptomycin for all strains was higher than 312 microgram/ml. Nearly 90% of these strains carried resistance plasmids. However, 3 strains possessed no plasmids and were assumed to be mutants. 60% of the plasmid-carrying strains have been able to transfer the resistance by conjugation. The rest have shown small plasmids, some of them were characterized by streptomycin and sulphonamide resistance and a molecular weight of 4.1 mega-daltons.
D004352:Drug Resistance, Microbial; D004534:Egypt; D004587:Electrophoresis, Agar Gel; D004754:Enterobacter / Q000187:drug effects / Q000235:genetics; D004755:Enterobacteriaceae / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D005243:Feces / Q000382:microbiology*; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000235:genetics; D009154:Mutation; D010957:Plasmids; D013307:Streptomycin / Q000494:pharmacology* / Q000627:therapeutic use
D013307:Streptomycin