Intestinal glucose and sodium transport and its relation to hypertension.
Final carbohydrate digestion by brush disaccharidases is closely linked to the transport of the resulting monosaccharides. A bifunctional carrier operates within the brush-border membrane of intestinal mucosal epithelial cells translocating glucologues and sodium due to a down-hill Na+ -gradient. Inhibition of final carbohydrate digestion by an inhibitor of a-glucoside-hydrolase activity results in reduction of glucose absorption from sucrose and even more marked inhibition of Na+ and water absorption. Modulation of the kinetic of carbohydrate absorption may be important in the control of post-prandial hyperglycemia of the diabetic, but no evidence exists that retardation of Na+ -absorption may be of importance in the hypertensive patient.
D020909:Acarbose; D000818:Animals; D001692:Biological Transport; D001834:Body Water / Q000378:metabolism; D004063:Digestion; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D007408:Intestinal Absorption; D012964:Sodium / Q000378:metabolism*; D013395:Sucrose / Q000378:metabolism; D014312:Trisaccharides / Q000378:metabolism
D014312:Trisaccharides; D013395:Sucrose; D012964:Sodium; D005947:Glucose; D020909:Acarbose