A rise in ambient temperature augments insulin absorption in diabetic patients.
The absorption rate of 125I-Actrapid insulin (6 U) from a subcutaneous injection site was examined in six insulin-dependent diabetic patients at ambient temperatures of 20 degrees C and 35 degrees C. During a 4-hr observation period, the insulin disappearance rate at 35 degrees C was 50%-60% greater than at 20 degrees C (p less than 0.01). Despite the small dose of insulin used, plasma glucose levels tended to be 1 to 2 mmole/liter lower at 35 degrees C than at 20 degrees C. These findings indicate that a rise in ambient temperature augments insulin absorption, in insulin-treated diabetic patients.
D000042:Absorption; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000188:drug therapy*; D006358:Hot Temperature; D006801:Humans; D007328:Insulin / Q000378:metabolism* / Q000627:therapeutic use; D061389:Insulin, Regular, Pork; D007700:Kinetics; D008297:Male; D012881:Skin Temperature
D001786:Blood Glucose; D007328:Insulin; D061389:Insulin, Regular, Pork; C000006:insulin, neutral