[Immunologic disorders in mice reared by mothers with induced graft vs host reactions].
The mice fed by foster mothers with the induced graft-versus-host reaction showed high lethality at the age of 2-3 months and second year of life. During the second month of life the sick progeny exhibited lymphopenia, delayed skin allograft rejection, diminished number of T lymphocytes in the spleen and lymph nodes, depressed immune response to erythrocytic and abdominal typhi Vi-antigen. The immune response in old mice was elevated. Postmortem histological examination of 35 mice revealed tumours of lymphoid and reticular tissue in 6 and amyloidosis of the liver and spleen in 15 cases.
D000367:Age Factors; D000686:Amyloidosis / Q000209:etiology; D000818:Animals; D005260:Female; D006087:Graft vs Host Reaction; D006462:Hemolytic Plaque Technique; D006824:Hybridization, Genetic; D007153:Immunologic Deficiency Syndromes / Q000209:etiology*; D008198:Lymph Nodes / Q000166:cytology; D008223:Lymphoma / Q000209:etiology; D008231:Lymphopenia / Q000209:etiology; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000166:cytology
Immunologicheskie narusheniia u mysheĭ, vskormlennykh materiami s indutsirovannoĭ u nikh reaktsieĭ transplantat protiv khoziaina.