Impaired bacteriological responses in babies after maternal iron dextran infusion.
The effect of a total dose infusion of iron dextran in pregnancy on 15 mothers and their babies was compared with 19 controls. The bacteriostatic effect and opsonising ability of the sera, of babies born to the treated mothers, were considerably impaired. This was associated with a significantly lower transferrin concentration in these mothers. Although these in vitro tests were not associated with an increase in overt infection during the perinatal period, they suggest the need for caution in the use of total dose infusions in pregnancy.
D001770:Blood Bactericidal Activity / Q000187:drug effects*; D004926:Escherichia coli / Q000254:growth & development; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D007263:Infusions, Parenteral; D007501:Iron / Q000097:blood; D007505:Iron-Dextran Complex / Q000008:administration & dosage / Q000627:therapeutic use*; D008431:Maternal-Fetal Exchange; D009895:Opsonin Proteins / Q000276:immunology; D011247:Pregnancy; D014168:Transferrin / Q000032:analysis
D006454:Hemoglobins; D009895:Opsonin Proteins; D014168:Transferrin; D007505:Iron-Dextran Complex; D007501:Iron