Effect of nifedipine on glucose tolerance and insulin secretion in diabetic and non-diabetic patients.
The effect of the acute and long-term oral administration of nifedipine on glucose and insulin levels during a standard oral glucose tolerance test was studied in a total of 8 diabetic and 8 non-diabetic patients. No significant effect weas found on either glucose or insulin levels or on serum calcium and phosphate concentrations. The drug was withdrawn in 2 patients because of side-effects and failure of response, respectively. When used in standard recommended oral dosage nifedipine has no significant effect on glucose tolerance.
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy; D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology* / Q000627:therapeutic use; D011725:Pyridines / Q000494:pharmacology*; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D011725:Pyridines; D009543:Nifedipine