Plasma renin activity and vasodepressor action of prostacyclins with modified omega-side chain in anesthetized rats.
The effects of intravenous injection of prostacyclin (PGI2) and two of its analogues with modified omega-side chain on systemic blood pressure and on plasma renin activity were investigated in anesthetized rats. The PGI2 -methylester analogues with replacement of the n-pentyl moiety attached to C-15 by cyclohexyl or 3-thienyloxymethyl had exactly the same vasodepressor activities as PGI2. Despite these equipotent effects on blood pressure a marked difference between PGI2 and the analogues with respect to stimulation of plasma renin activity could be demonstrated. The cyclohexyl as well as the 3-thienyloxymethyl analogue induced a significantly stronger increase of plasma renin activity than PGI2. These findings strengthen the view of a direct involvement of prostacyclins in renin release mechanisms.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003510:Cyclohexanes / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000494:pharmacology*; D008297:Male; D011453:Prostaglandins / Q000494:pharmacology*; D011465:Prostaglandins, Synthetic / Q000494:pharmacology*; D051381:Rats; D012083:Renin / Q000097:blood*; D013876:Thiophenes / Q000494:pharmacology
D003510:Cyclohexanes; D011453:Prostaglandins; D011465:Prostaglandins, Synthetic; D013876:Thiophenes; D011464:Epoprostenol; D012083:Renin