Transient populations of terminal transferase positive (TdT+) cells in juvenile rats and mice.
Transient populations of TdT+ cells are present in peripheral blood, lung, liver, and spleen of rats and mice between birth and 7 wk of age. TdT+ blood cells appear to be post-thymic cells, as evidenced by their absence from nu/nu mice and their pattern of TdT fluorescence. TdT+ cells in lung, liver, and spleen appear to be prethymic cells. All transient populations of TdT+ cells are sensitive to dexamethasone. Only TdT+ cells in bone marrow and thymus persist into adult life.
D000375:Aging; D000818:Animals; D001853:Bone Marrow / Q000276:immunology; D004254:DNA Nucleotidyltransferases / Q000276:immunology*; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D005455:Fluorescent Antibody Technique; D008099:Liver / Q000276:immunology; D008168:Lung / Q000276:immunology; D008297:Male; D051379:Mice; D008819:Mice, Nude; D011817:Rabbits; D051381:Rats; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000145:classification*; D013950:Thymus Gland / Q000276:immunology
D003907:Dexamethasone; D004254:DNA Nucleotidyltransferases