The effect of in situ formation of antigen-antibody complexes in the glomerulus on subsequent glomerular localization of passively administered immune complexes.
In situ formation of antigen-antibody complexes in the mouse glomerulus was found to enhance the deposition of immune complexes subsequently injected passively. Administration of a large antigen excess to mice that had been given pre-formed immune complexes following in situ complex formation resulted in an apparent mobilization of immune deposits as compared to mice given pre-formed complexes alone, where no such mobilization occurred.
D000818:Animals; D000936:Antigen-Antibody Complex; D000941:Antigens / Q000276:immunology; D003176:Complement C3 / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D007116:Immunization, Passive; D007678:Kidney Glomerulus / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D012710:Serum Albumin, Bovine / Q000276:immunology
D000936:Antigen-Antibody Complex; D000941:Antigens; D003176:Complement C3; D012710:Serum Albumin, Bovine