title: Studies on group B beta-hemolytic Streptococcus. II. Effects on pulmonary hemodynamics and vascular permeability in unanesthetized sheep.
abstract: To study the effects of Group B beta-hemolytic Streptococcus on the pulmonary circulation and lung fluid balance, live and heat-killed bacteria and their toxin were infused into an awake sheep lung-lymph preparation. In every case, the response was biphasic; there was an initial period of marked pulmonary hypertension and high flow of protein-poor lymph associated with tachypnea, chills, and fever. A second phase followed during which pulmonary vascular pressures returned to near baseline and remained stable, but lymph flow remained high. The changes seen in the initial phase resemble the previously reported response to mechanically increased pulmonary vascular pressure and suggest that the increase in fluid filtration is secondary to increased microvascular pressure. During the second phase after toxin infusion, the increase in lung lymph flow was paralleled by an increase in lymph protein clearance. This cannot be accounted for by the hemodynamic changes alone an suggests that the permeability of lung microvascular walls to protein was increased. It is concluded that group B beta-hemolytic streptococcal toxin in the sheep model causes pulmonary hypertension and increased pulmonary vascular permeability.
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000633:toxicity; D002199:Capillary Permeability; D006439:Hemodynamics; D006976:Hypertension, Pulmonary / Q000209:etiology; D011506:Proteins / Q000378:metabolism; D011652:Pulmonary Circulation; D012756:Sheep; D013290:Streptococcal Infections / Q000503:physiopathology*; D013292:Streptococcus agalactiae
chemical_list: D001427:Bacterial Toxins; D011506:Proteins