title: Control of insulin-dependent diabetes with portable miniaturized infusion systems.
abstract: A method of insulin therapy that appears to achieve better control of diabetes than present conventional methods is the use of insulin infusion devices--either glucose-controlled feedback (closed-loop) systems or the preprogrammed (open-loop) infusion pump. In view of the problems with implantable glucose sensors, we have worked to develop a miniaturized, programmable infusion system. Its use in insulin-dependent diabetic patients to provide either intravenous doses or a continuous subcutaneous insulin infusion resulted in significant reductions in blood glucose levels, glycemic excursions and 24-h glucose excretion.
mesh_terms: D001786:Blood Glucose; D003920:Diabetes Mellitus / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004582:Electronics, Medical / Q000295:instrumentation*; D006801:Humans; D007275:Injections, Intravenous / Q000295:instrumentation / Q000379:methods*; D007279:Injections, Subcutaneous / Q000295:instrumentation / Q000379:methods*; D007328:Insulin / Q000008:administration & dosage*; D008991:Monitoring, Physiologic
chemical_list: D001786:Blood Glucose; D007328:Insulin