[Immunological monitoring after renal transplantation from living donors].
Monitoring of immune responses were done in kidney recipients from living donors using the following assays: CH-50, alternative pathway of complement activation, circulating Ag-Ab complexes, cytotoxic antibodies. All patients had survived 3 to 5 years from transplant. While some alternations (fall of CH-50, cytotoxic antibodies, circulating Ag-Ab complexes) occurred after the episodes of chronic rejection in 2 patients, despite a well functioning allograft, the inhibition of alternative pathway of complement activation demonstrated a coincidental capability to predict rejection episodes. The blocking mechanism of the alternative pathway of complement activation during rejection is not fully understood. The enhancing role of B-lymphocyte antibodies and the function of circulating immunecomplexes were also discussed.
D000906:Antibodies / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000032:analysis; D001402:B-Lymphocytes; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D006084:Graft Rejection; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D016030:Kidney Transplantation; D007958:Leukocyte Count; D008297:Male; D011182:Postoperative Care; D014019:Tissue Donors; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D000906:Antibodies; D000936:Antigen-Antibody Complex; D006680:HLA Antigens; D003165:Complement System Proteins
Monitoraggio immunologico dopo trapianto renale da donatore vivente.