title: [Antibody response to histocompatibility antigens in hemodialysis patients subjected to planned whole-blood transfusions].
abstract: In hemodialysis patients planned whole blood transfusions from single donors, induce the formation of anti HLA A, B, C and DR cytotoxic antibodies. The percentage of immunization, however, is lower than that observed in healthy subjects immunized following a similar transfusional schedule. This observation may reflect the existence in some patients of an impairment of the immune response to histocompatibility antigens. The production of lymphocytotoxic antibodies appear to be associated with severe graft rejections while anti HLA antibodies detected only by an indirect rosette assai don't seem to play a significant role in the outcome of the transplants.
mesh_terms: D000293:Adolescent; D000328:Adult; D000906:Antibodies; D000917:Antibody Formation; D001803:Blood Transfusion; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D007111:Immunity, Cellular; D007676:Kidney Failure, Chronic / Q000628:therapy; D016030:Kidney Transplantation; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D011300:Preoperative Care; D006435:Renal Dialysis; D014184:Transplantation, Homologous
chemical_list: D000906:Antibodies; D006680:HLA Antigens
vernacular_title: Risposta anticorpale agli antigeni della istocompatibilità in pazienti in dialisi sottoposti a trasfusioni pianificate di sangue in toto.