[Insulin analogues with substitution of A1-glycine by D-amino acids and omega-amino acids (author's transl)].
Substitution of A1-glycine of insulin by L-amino acids yields in analogues with low biological activity. With D-amino acids in A1 biological activity is essentially retained. The influence of aliphatic, aromatic, acidic and basic alpha-D-amino acids as well as omega-amino acids in A1 on the biological effects in different test systems is studied and discussed.
D000596:Amino Acids; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D005998:Glycine; D007328:Insulin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D008214:Lymphocytes / Q000378:metabolism; D008722:Methods; D011817:Rabbits; D011972:Receptor, Insulin / Q000378:metabolism; D013329:Structure-Activity Relationship
D000596:Amino Acids; D001786:Blood Glucose; D007328:Insulin; D011972:Receptor, Insulin; D005998:Glycine
Insulinanaloga durch Austausch von A1-Glycin gegen D-Aminosäuren und omega-Aminosäuren.