The binding of trimethoprim to bacterial dihydrofolate reductase.
D003460:Crystallization; D004926:Escherichia coli / Q000201:enzymology*; D005583:Fourier Analysis; D046911:Macromolecular Substances; D008727:Methotrexate / Q000378:metabolism; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*; D014295:Trimethoprim / Q000378:metabolism*
D046911:Macromolecular Substances; D014295:Trimethoprim; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate