[Pharmacokinetics, tolerance and therapeutic effect of trimethoprim-sulfametrol-infusions (author's transl)].
Lidaprim was administered as infusion to 6 healthy volunteers for 10 days in an interval of 12 hours for calculation of the pharmacokinetic parameters. Furthermore 31 patients with various severe infectious diseases were treated for 5-27 days with 2 or 3 infusions daily. Local tolerance was excellent. Side effects were observed only in 1 patient, who developed a rash. The cumulation equilibrium is reached for trimethoprim and also for total and free sulfonamide on the 3rd day. The clinical results were excellent: 22 of the 31 patients with severe infectious diseases could be cured.
D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004361:Drug Tolerance; D006207:Half-Life; D006801:Humans; D007263:Infusions, Parenteral; D012141:Respiratory Tract Infections / Q000188:drug therapy; D013449:Sulfonamides / Q000627:therapeutic use*; D014295:Trimethoprim / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy
D004338:Drug Combinations; D013449:Sulfonamides; D014295:Trimethoprim
Pharmakokinetik, Verträglichkeit und therapeutische Wirkung von Trimethoprim-Sulfametrol-Infusionen.