Proteinuria and nephrotic syndrome induced by renin in patients with renal artery stenosis.
Exacerbation of hypertension and a marked excretion of protein in the urine were observed in three patients in the absence of underlying renal parenchymal disease or other causes of proteinuria. Stenosis of a renal artery and hyperreninemia were present in all three patients. Correction of the stenosis by arterial bypass or nephrectomy resulted in a rapid decrease in urinary protein excretion. The relationship between the levels of renin activity and the proteinuria in one patient and long-term follow-up in the other two patients are reported, and the mechanisms of this proteinuria are reviewed. Renal artery stenosis may be the underlying cause in some cases of idiopathic nephrotic syndrome.
D000368:Aged; D001794:Blood Pressure; D001807:Blood Vessel Prosthesis / Q000379:methods; D003251:Constriction, Pathologic; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000378:metabolism; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000209:etiology*; D011507:Proteinuria / Q000175:diagnosis / Q000209:etiology*; D012078:Renal Artery Obstruction / Q000150:complications* / Q000601:surgery; D012083:Renin / Q000097:blood*
D012083:Renin