Mutagenicity of methylated fluorenes and benzofluorenes.
Methylated fluorenes were assayed for mutagenic activity towards Salmonella typhimurium TA98 and TA100. None of these methylfluorenes were mutagenic in the absence of metabolic activation. In the presence of 9000 X g supernatant from Aroclor-induced rats, 9-methylfluorene and 1,9-dimethylfluorene were active towards TA98 and TA100. The structural requirement for mutagenic activity within this series was the presence of a single methyl substituent at the 9-position. Enhanced mutagenic activity was also observed for benzofluorenes similarly methylated at their benzylic positions.
D000818:Animals; D001711:Biotransformation; D005449:Fluorenes / Q000378:metabolism / Q000494:pharmacology*; D008745:Methylation; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics; D013329:Structure-Activity Relationship
D005449:Fluorenes; D009153:Mutagens; C030637:1,9-dimethylfluorene; C030636:9-methylfluorene