Induction of an ornithine decarboxylase-antizyme by diaminopropane in chicken kidney and intestinal mucosa.
Administration of diaminopropane to chickens, injected with insulin in order to induce ornithine decarboxylase, prevents the increase of the decarboxylase activity in kidney and in the intestinal mucosa, not in the heart, In the first two tissues, not in the last one, an ornithine decarboxylase-antizyme is detected. The ornithine decarboxylase-antizyme appears therefore to be involved in vivo in the regulation of ornithine decarboxylase activity.
D000818:Animals; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D002645:Chickens; D003959:Diamines / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000096:biosynthesis*; D007328:Insulin / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000201:enzymology*; D007668:Kidney / Q000201:enzymology*; D008297:Male; D009206:Myocardium / Q000201:enzymology; D009955:Ornithine Decarboxylase / Q000378:metabolism; D065108:Ornithine Decarboxylase Inhibitors
D003959:Diamines; D004791:Enzyme Inhibitors; D007328:Insulin; D065108:Ornithine Decarboxylase Inhibitors; C009475:trimethylenediamine; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase