Antagonism of excitatory amino acid-induced and synaptic excitation of spinal neurones by cis-2,3-piperidine dicarboxylate.
In tests on neurones in the cat spinal cord in vivo, and frog and immature rat spinal cord in vitro, cis-2,3-piperidine dicarboxylate (cis-2,3-PDA) produced the following effects: (1) selective antagonism of amino acid-induced responses, compared with responses to other putative transmitters; (2) effective antagonism of kainate and quisqualate-induced responses in addition to responses induced by N-methyl-D-aspartate (NMDA) and other excitatory amino acids; (3) partial NMDA-like agonist action; (4) antagonism of dorsal root-evoked excitation of Renshaw cells; (5) potentiation of acetylcholine- and ventral root-evoked excitation of Renshaw cells. This unique spectrum of action may be useful for transmitter receptor characterization in the vertebrate central nervous system.
D000409:Alanine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors; D000596:Amino Acids / Q000037:antagonists & inhibitors*; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors; D002415:Cats; D018691:Excitatory Amino Acid Antagonists; D066298:In Vitro Techniques; D007608:Kainic Acid / Q000037:antagonists & inhibitors; D016202:N-Methylaspartate; D009474:Neurons / Q000187:drug effects*; D010069:Oxadiazoles / Q000037:antagonists & inhibitors; D010875:Pipecolic Acids / Q000494:pharmacology*; D016318:Quisqualic Acid; D011896:Rana temporaria; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology; D013569:Synapses / Q000502:physiology*
D000596:Amino Acids; D018691:Excitatory Amino Acid Antagonists; D010069:Oxadiazoles; D010875:Pipecolic Acids; D001224:Aspartic Acid; C029262:2,3-piperidinedicarboxylic acid; D016202:N-Methylaspartate; D016318:Quisqualic Acid; D000409:Alanine; D007608:Kainic Acid