A new mutagenic and genotoxic response of the flame retardant tris(2,3-dibromopropyl)phosphate. Activation by singlet oxygen.
Illumination of tris (2,3-dibromopropyl)phosphate with visible light in the presence of riboflavin resulted in the formation of a stable product with greatly enhanced genetic and DNA-modifying activities. Because illumination of riboflavin results in the formation of short-lived singlet oxygen, it is assumed that the mutagenic and genotoxic chemical results from a reaction between the flame retardant and singlet oxygen. Since the polluted urban atmosphere is conducive to the generation of this species of oxygen, the present results may, therefore, be relevant to an assessment of the health hazard posed by such an environment.
D000393:Air Pollutants; D055598:Chemical Phenomena; D002621:Chemistry; D004269:DNA, Bacterial / Q000235:genetics; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005411:Flame Retardants / Q000633:toxicity*; D006842:Hydrocarbons, Brominated / Q000633:toxicity; D009153:Mutagens; D010755:Organophosphates; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010100:Oxygen; D012486:Salmonella typhimurium / Q000187:drug effects
D000393:Air Pollutants; D004269:DNA, Bacterial; D005411:Flame Retardants; D006842:Hydrocarbons, Brominated; D009153:Mutagens; D010755:Organophosphates; D009943:Organophosphorus Compounds; C012085:tris(2,3-dibromopropyl)phosphate; D010100:Oxygen