Effect of prostaglandins and thromboxane A2 on the contractility of rabbit splenic capsular smooth muscle.
The effect of various prostaglandins (PGs) and a thromboxane A2 (TXA2)-generating system on the contractility of rabbit splenic capsular smooth muscle has been investigated. PGI2 as well as higher concentrations of PGE1 and 5, 6 beta-dihydro-PGI2 inhibit noradrenaline-induced contractions of the smooth muscle preparation. The TXA2-generating system and high concentrations of PGD2, on the other hand, increase the contractions. The results support the concept that the hypothetical PGI2 receptor on the smooth muscle of the rabbit splenic capsule resembles, in its specificity, the PGI2 receptor on platelets.
D000818:Animals; D011464:Epoprostenol / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011462:Prostaglandins G / Q000494:pharmacology; D011817:Rabbits; D013154:Spleen; D013928:Thromboxane A2 / Q000494:pharmacology*; D013931:Thromboxanes / Q000494:pharmacology*
D011453:Prostaglandins; D011458:Prostaglandins E; D011462:Prostaglandins G; D013931:Thromboxanes; D013928:Thromboxane A2; D011464:Epoprostenol; D009638:Norepinephrine