Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness.
Living skin-equivalent grafts consisting of fibroblasts cast in collagen lattices and seeded with epidermal cells were successfully grafted onto the donors of the cells. The grafts were vascularized, did not evoke a homograft reaction, inhibited wound contraction, filled the wound space, and persisted.
D000818:Animals; D001672:Biocompatible Materials; D003094:Collagen; D000078404:Epidermal Cells; D005110:Extracellular Space; D005347:Fibroblasts / Q000637:transplantation*; D006084:Graft Rejection; D008297:Male; D051381:Rats; D016038:Skin Transplantation; D014945:Wound Healing
D001672:Biocompatible Materials; D003094:Collagen