Morphine-induced hyperglycemia: role of insulin and glucagon.
An iv bolus injection of 0.5 mg/kg morphine, about twice the therapeutic dose, caused plasma glucose to rise more than 120 mg/dl in alloxan-diabetic conscious dogs but had little effect on conscious normal dogs. Plasma glucagon rose in the diabetic and nondiabetic groups by 30 +/- 10 and 100 +/- 29 pg/ml, respectively, but insulin levels increased significantly only in the nondiabetics. The hyperglycemic action on morphine may, at least in part, be the result of an increase in glucagon secretion without a sufficient accompanying release of insulin.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D004285:Dogs; D005934:Glucagon / Q000097:blood; D006943:Hyperglycemia / Q000097:blood* / Q000139:chemically induced; D007328:Insulin / Q000097:blood*; D009020:Morphine / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D009020:Morphine; D005934:Glucagon