[Synthesis and serum cholesterol-lowering and uterotropic effects of 15,16,17-trisubstituted oestratriene 3-methyl ethers. Part 63: On steroids (author's transl)].
The preparation of the 17 beta-carbamoyl derivatives 4 and of the 17 beta-carbonic acid esters 5 from 15 beta,16 beta-epoxy-3-methoxyoestra-1,3,5(10)-triene-17 beta-ol (3a), and the subsequent opening of the 15 beta,16 beta-epoxy group resulting in 15 beta,16 alpha,17 beta-trisubstituted oestratrienes 6 are described. The influences of several substitutents in the positions 15 and 16 and of the 17 beta-hydroxy group and derivatives thereof on the uterotropic and cholesterol-lowering activities were investigated in rats after oral application. A correlation between the cholesterol-lowering and the uterotropic activity could be established. Activity dissociation was not achieved.
D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis*; D004963:Estrenes / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D008297:Male; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects*
D000924:Anticholesteremic Agents; D004963:Estrenes
Synthese, serumcholesterolsenkende und uterotrope Wirkung von 15,16,17-trisubstituierten Ostratrien-3-methylethern. 63. Mitteilung: Uber Steroide.