The effect of pineal polypeptides and melatonin on serum and pituitary LH and FSH in adult male rats.
The effect of a pineal polypeptide extract was tested against the effect of melatonin on the serum level and pituitary concentration of LH and FSH of the adult male rat both in basal conditions and in response to exogenous (GnRH) and endogenous (castration) stimulation. A 2 ml dose of pineal polypeptides per injection caused a signifcant fall in serum LH and FSH both in the intact, the intact + GnRH, and the castrated animals. The decrease in pituitary concentration of LH and FSH was of statistical significance only in stimulation conditions. A 50 micrograms dose of melatonn/injection failed to produce comparable effects. The antigondaotropic action of the biologically active pineal compounds is discussed.
D000818:Animals; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D010870:Pineal Gland; D010903:Pituitary Gland, Anterior / Q000187:drug effects; D010906:Pituitary Hormone-Releasing Hormones / Q000097:blood; D051381:Rats; D013972:Thyrotropin / Q000097:blood*
D010455:Peptides; D010906:Pituitary Hormone-Releasing Hormones; D007986:Luteinizing Hormone; D013972:Thyrotropin; D008550:Melatonin