An assay for antigen-antibody complexes in human sera using C1q-enzyme conjugates.
An assay for soluble immune complexes employing enzyme-C1q conjugates is described. The method is sensitive, rapid and precise, and should prove suitable for monitoring patients. The test gave positive results for complexes in normal pregnant women and indicated significantly increased levels in subjects with pre-eclampsia.
D000936:Antigen-Antibody Complex / Q000032:analysis*; D003166:Complement Activating Enzymes / Q000494:pharmacology*; D015922:Complement C1q; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008297:Male; D011225:Pre-Eclampsia / Q000276:immunology; D011247:Pregnancy; D011259:Pregnancy Tests, Immunologic
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D015922:Complement C1q; D003166:Complement Activating Enzymes