Cell-mediated hyperacute rejection. I. Acute, accelerated, and hyperacute reactions.
The morphology of first-set rejection of allogeneic murine skin grafts differs strikingly from that usually seen subsequent to sensitization. In the former, graft epithelium appears to be the primary target; in the latter, the endothelium of graft vessels. This difference suggests that different subsets of effector T cells may be involved. This paper reports an attempt to isolate, for further characterization, a T cell population associated with first-set rejection. The relationships between acute and hyperacute rejection of organ transplants and of murine skin grafts are discussed, as is the possible role of endothelium-specific antigens and receptors sites.
D000818:Animals; D005260:Female; D006084:Graft Rejection; D007111:Immunity, Cellular; D007112:Immunity, Maternally-Acquired; D007114:Immunization; D008221:Lymphoid Tissue / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D012867:Skin / Q000276:immunology / Q000473:pathology; D016038:Skin Transplantation; D014181:Transplantation Immunology; D014184:Transplantation, Homologous