[Are des-Phe-insulin-containing insulin combinations preferable to regular trade preparations?].
Des-phe-insulins are modified insulins in which phenylalanin is eliminated from the b-chain of the normal insulin. Preparations containing des-phe-insulin and cristalline insulin have a good stability and one can produce insulins with different profiles. 50 diabetics were treated with different des-phe-insulin containing preparations. The carbohydrate metabolism was well controlled during the application of the new preparations. There were no side effects nor skin allergies. Des-phe-insulin containing insulins present a new interesting aspect in the treatment of insulin dependent diabetes mellitus.
D000328:Adult; D000368:Aged; D003692:Delayed-Action Preparations / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000188:drug therapy*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D049528:Insulin, Long-Acting / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
D003692:Delayed-Action Preparations; D004338:Drug Combinations; D007328:Insulin; D049528:Insulin, Long-Acting; C030808:insulin, (B1)-des-Phe-
Sind Des-Phe-Insulin-haltige Insulinmischungen handelsüblichen Präparaten vorzuziehen?