Genetic regulation of the expression of H-2-K.5 antigen of erythroid cells by H-2K end.
Difference in the amounts of H-2K.5 antigens present on erythrocytes was observed, using quantitative absorption method, among several B 10 congenic strains. However, no such variation was seen on the lymphocytes and lung cells. The variability in the amount of this antigen on the erythrocyte surface was primarily dependent on the haplotype of the H-2K end in the B 10 recombinant strains examined. This suggests that the regulator of H-2 expression on erythrocytes is in this region. Further genetic analysis confirmed that this regulation functions in the cis-position. Finally, the H-2K.5 antigenic activity was expressed on the reticulocytes of all strains tested, but appeared lower in the type 2 group indicating that the regulation begins early in erythropoietic differentiation and eventually results in a complete loss of detectable activity.
D000818:Animals; D002454:Cell Differentiation; D003601:Cytotoxicity Tests, Immunologic; D004912:Erythrocytes / Q000276:immunology*; D006183:H-2 Antigens / Q000235:genetics* / Q000276:immunology; D007163:Immunosorbent Techniques; D008168:Lung / Q000166:cytology / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology*
D006183:H-2 Antigens