Cimetidine does not accelerate skin graft rejection in mice.
The influence of cimetidine on skin graft rejection was studied in a well defined transplantation model of inbred mice. Four allogeneic transplantation combinations with increasing antigenic disparity and one xenograft combination were studied. Cimetidine (25 mg/kg body weight) was administered intraperitoneally at 8-hr intervals until rejection occurred. No differences in graft survival were observed between cimetidine-treated groups and saline-treated controls in any of the combinations studied.
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D006084:Graft Rejection / Q000187:drug effects*; D006146:Guanidines / Q000494:pharmacology*; D006183:H-2 Antigens / Q000032:analysis; D051379:Mice; D008815:Mice, Inbred Strains; D016038:Skin Transplantation; D013997:Time Factors; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
D006146:Guanidines; D006183:H-2 Antigens; D002927:Cimetidine