Hemosiderosis without cirrhosis: an unusual case of portal hypertension.
A renal transplant recipient presented with bleeding esophageal varices. Needle biopsy, later confirmed by operative wedge biopsy, showed slight periportal fibrosis but no cirrhosis or hepatitis. No etiology for his liver disease could be determined and he could not be differentiated from other reported patients with idiopathic noncirrhotic portal hypertension (IPH). His liver biopsy did show massive hepatic iron deposition. He had received about 115 units of blood while on hemodialysis and had taken oral iron supplementation for 8 years. IPH has been associated with toxin exposure, especially arsenic and vinyl chloride. This case suggests that excessive iron deposition may also lead to IPH and the indiscriminate use of iron supplementation in hemodialysis or renal transplant patients should be avoided.
D000328:Adult; D006486:Hemosiderosis / Q000139:chemically induced*; D006801:Humans; D006975:Hypertension, Portal / Q000139:chemically induced* / Q000378:metabolism; D007501:Iron / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D014184:Transplantation, Homologous
D007501:Iron