A comparison of two prophylactic antibiotic regimes for open-heart surgery.
Two groups of patients undergoing open-heart surgery were given prophylactic courses of antibiotic lasting five days. One group (61 patients) received a cephalosporin and the second (57 patients) received a combination of penicillin, flucloxacillin and streptomycin. The overall major infection rate was low (3--4%), particularly so in the cephalosporin group (1.6%). There was no increased nephrotoxic effectt of the cephalosporin, and any nephrotoxic effect that was present was temporary and clinically unimportant. The major infecting organism in both groups was Staphylococcus albus (Staph. epidermidis). The efficiency, therefore, of any prophylactic regime which omits gentamicin, to which Staph. albus in usually sensitive, remains in doubt.
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001424:Bacterial Infections / Q000517:prevention & control*; D006348:Cardiac Surgical Procedures; D002511:Cephalosporins / Q000008:administration & dosage* / Q000009:adverse effects; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D005436:Floxacillin / Q000008:administration & dosage; D005839:Gentamicins / Q000008:administration & dosage; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000008:administration & dosage; D011183:Postoperative Complications / Q000517:prevention & control*; D011300:Preoperative Care; D013203:Staphylococcal Infections / Q000517:prevention & control; D013307:Streptomycin / Q000008:administration & dosage; D014508:Urea / Q000097:blood
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D005839:Gentamicins; D010406:Penicillins; D005436:Floxacillin; D014508:Urea; D003404:Creatinine; D013307:Streptomycin