title: [Role of age in the process of the development of experimental alcoholism in rats of both sexes].
abstract: It has been shown that under free access to liquids 8% ethanol preference to water is developed more rapidly in sexually immature females and more slowly in sexually immature males as compared to sexually mature rats of the respective sex. Sexually immature animals of both sexes are involved simultaneously in the process of alcoholization. In sexually mature animals the degree of ethanol preference to water measured in grams of consumed alcohol per 1 kg body weight is 2--3 times greater than that in sexually mature ones and decreases with age. In sexually immature animals of both sexes the degree of ethanol preference in females significantly exceeds that in males at the onset of preference development while in sexually mature rats such a predominance can be ascertained only after the preference development has been completed.
mesh_terms: D000375:Aging; D000437:Alcoholism / Q000209:etiology*; D000818:Animals; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D051381:Rats; D012741:Sexual Maturation / Q000187:drug effects; D013997:Time Factors
chemical_list: D000431:Ethanol
vernacular_title: Rol' vazrasta v protsesse formirovaniia éksperimental'nogo alkogolizma u krys raznogo pola.