Enhancement of host susceptibility to Staphylococcus aureus infection by chronic ethanol ingestion--modification by glucan immunostimulation.
The susceptibility of chronic ethanol-treated mice to S. aureus infection was ascertained, as was the ability of the immunostimulant glucan to modify ethanol-induced susceptibility to infection. Chronic alcohol-treated mice showed enhanced sensitivity to S. aureus. The administration of glucan significantly prolonged survival in S. aureus infected control and chronic ethanol mice.
D000437:Alcoholism / Q000276:immunology*; D000818:Animals; D005936:Glucans / Q000494:pharmacology*; D006801:Humans; D007109:Immunity / Q000187:drug effects; D007668:Kidney / Q000473:pathology; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D009113:Muramidase / Q000097:blood; D013203:Staphylococcal Infections / Q000201:enzymology / Q000276:immunology* / Q000382:microbiology; D013997:Time Factors
D005936:Glucans; D009113:Muramidase