Effect of a fast-growing ascites hepatoma (Yoshida AH-130) on proteinase activities in the rat liver.
The weight of the liver and its DNA content definitely increase in rats transplanted with the ascites hepatoma AH-130 (Yoshida). The specific activity of cathepsin B1 decreases progressively in the liver during the first week after transplantation reaching one third of the initial levels, whereas that of cathepsin D shows the opposite behaviour increasing to levels 40% higher than in controls. The activity of the two proteinases in the blood plasma varies in a similar way, though the modifications are even more pronounced than in the liver. The relevance of the changes in tissue proteinase activities to the liver growth in tumour-bearing animals is discussed.
D000818:Animals; D002403:Cathepsins / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D010450:Endopeptidases / Q000032:analysis*; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology; D011506:Proteins / Q000378:metabolism; D051381:Rats
D011506:Proteins; D004247:DNA; D002403:Cathepsins; D010450:Endopeptidases