Synchronization of oestrus in adult female rats by utilizing the paradoxical effects of an LH-RH agonist.
Implantation of 25 microgram per rat of an LH-RH agonist, [Des-Gly10,D-Ala6,lProNHEt9]LH-RH, contained within a cholesterol matrix pellet caused a complete and continued suppression of oestrus in rats within 3 days. Removal of the pellets after 7 days led to synchronized oestrus 4 days later in 90-95% of the animals (N = 30); the remaining animals became oestrous on the 5th day. Fertility of these treated rats mated at the synchronized oestrus was equivalent to that of a control, sham-operated population allowed to mate over a 3-day period.
D000818:Animals; D004971:Estrus / Q000187:drug effects*; D004973:Estrus Synchronization; D005260:Female; D005298:Fertility / Q000187:drug effects; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats
D007987:Gonadotropin-Releasing Hormone; C010661:surfagon