Ritodrine in the treatment of preterm labour. A clinical trial to compare a standard treatment with three regimens involving the use of ritodrine.
In a randomized trial, three alternative schemes of treatment of preterm labour with ritodrine (long infusion, short infusion, and intramuscular injection) were compared with standard treatment by bed rest and sedatives. None of the ritodrine treatments were found to be better in postponing delivery than the standard treatment. However, the Bishop scores of the patients in the standard treatment group tended to be lower than of the patients treated with ritodrine. Moreover, all cases of congenital malformation and polyhydramnios occurred in the patients treated with ritodrine. The incidence of respiratory insufficiency was significantly higher in infants of mothers treated with ritodrine. The mean birth weight was highest in the standard treatment group.
D000328:Adult; D001724:Birth Weight; D002986:Clinical Trials as Topic; D000013:Congenital Abnormalities; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007263:Infusions, Parenteral; D007273:Injections, Intramuscular; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D006831:Polyhydramnios / Q000150:complications; D011247:Pregnancy; D011412:Propanolamines / Q000008:administration & dosage*; D011897:Random Allocation; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology; D012312:Ritodrine / Q000008:administration & dosage* / Q000627:therapeutic use
D011412:Propanolamines; D012312:Ritodrine