Pharmacological induced depression of E-rosette forming cells (RFC) of normal healthy subjects. Restoration by levamisole and thymopoietin pentapeptide.
The authors describe a pharmacological inhibition of E-Rosette formation by the "in vitro" addition of adenosine and theophylline. In the same experimental conditions TP5 and levamisole are able to reverse this inhibiting activity. The role of the cyclic nucleotides (cAMP and cGMP) in the regulation of the lymphocytes response is discussed.
D000241:Adenosine / Q000494:pharmacology; D006801:Humans; D007104:Immune Adherence Reaction; D007978:Levamisole / Q000494:pharmacology*; D008214:Lymphocytes / Q000276:immunology*; D010446:Peptide Fragments / Q000494:pharmacology*; D012397:Rosette Formation; D013806:Theophylline / Q000494:pharmacology; D016305:Thymopentin; D013946:Thymopoietins / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*
D010446:Peptide Fragments; D013946:Thymopoietins; D013951:Thymus Hormones; D007978:Levamisole; D013806:Theophylline; D000241:Adenosine; D016305:Thymopentin