Blood transfusions and antibody response in patients waiting for a kidney transplant.
Cold and warm B and T cell antibodies have been investigated following blood transfusion in patients waiting for a kidney transplant. 18 out of 28 patients were sensitized after a single transfusion: half of them presented a B-warm pattern and the other half either a T-warm or a B-cold pattern. Several sera collected after one transfusion were absorbed with pooled platelets. All three T-warm sera have become negative after absorption. Out of 21 B-warm sera, 6 remained B-warm, 3 became B-cold and 12 were negative after absorption. There was no difference in strength between the B-warm sera which were absorbed and those which resisted to absorption. Dilution studies showed that sera followed a similar trend: they convert from T-warm to B-warm and B-cold patterns. Sequential sera from patients receiving systematic transfusions were tested at regular intervals after each transfusion. Most patients produced B-warm antibodies.
D000042:Absorption; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D001803:Blood Transfusion; D003080:Cold Temperature; D006358:Hot Temperature; D006801:Humans; D016030:Kidney Transplantation; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors