Binding of insulin to rat pancreatic islets: comparison between pancreatic human insulin and biosynthetic human insulin.
Human pancreatic insulin, biosynthetic human insulin (BHI), and pork insulin were compared in terms of their binding characteristics to insulin receptors on rat pancreatic islets. There was no difference in binding or on biologic effect, i.e., ability to inhibit insulin secretion.
D000818:Animals; D006801:Humans; D007328:Insulin / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000378:metabolism*; D007457:Iodine Radioisotopes; D007515:Islets of Langerhans / Q000378:metabolism*; D007700:Kinetics; D051381:Rats; D011972:Receptor, Insulin / Q000378:metabolism*
D007328:Insulin; D007457:Iodine Radioisotopes; C008147:insulin, iodo-; D011972:Receptor, Insulin