One month of sustained release of insulin from a polymer implant.
Rats made diabetic with streptozotocin received a single subcutaneous implant of an insulin polymer pellet that released insulin continuously at approximately 2 U/day. Continuous normoglycemia was achieved for up to 1 mo. Mean glucose level for treated animals was 113 mg/dl as compared with 398 mg/dl for untreated diabetic controls. Diurnal blood glucose values for treated animals ranged from 71 to 116 mg/dl. Polyuria and glycosuria were corrected by the presence of the insulin + polymer. Treated animals gained weight normally and reached a mean weight of 350 g, whereas untreated control animals lost weight, to a mean of 150 g. When insulin + polymer preparations were periodically implanted and removed at 7-day intervals, normoglycemia was only associated with the presence of implants.
D000818:Animals; D001786:Blood Glucose; D001835:Body Weight; D002940:Circadian Rhythm; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D004343:Drug Implants; D007328:Insulin / Q000008:administration & dosage* / Q000378:metabolism; D008297:Male; D011108:Polymers; D051381:Rats; D013997:Time Factors; D014753:Vinyl Compounds
D001786:Blood Glucose; D004343:Drug Implants; D007328:Insulin; D011108:Polymers; D014753:Vinyl Compounds