Interaction of timolol and adrenaline.
In a prospective double-blind randomised trial the interaction of timolol and adrenaline was studied in 20 patients with open-angle glaucoma and exfoliative glaucoma. After pretreatment for at least 2 weeks with timolol eyedrops adrenaline was added in a double-blind manner, and the intraocular pressure was recorded during 4 days. The study showed a significantly additive hypotensive effect of adrenaline, which was more pronounced in patients with exfoliative glaucoma.
D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004837:Epinephrine / Q000627:therapeutic use*; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D011412:Propanolamines / Q000627:therapeutic use*; D013999:Timolol / Q000627:therapeutic use*
D011412:Propanolamines; D013999:Timolol; D004837:Epinephrine