Globomycin sensitivity of Escherichia coli and Salmonella typhimurium: effects of mutations affecting structures of murein lipoprotein.
The sensitivity of strains of Escherichia coli and Salmonella typhimurium to globomycin is increased in mutants defective in the lipopolysaccharide structure. E. coli mutants altered in the structures or biosynthesis of murein lipoprotein are more resistant to globomycin than the parental strains.
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins / Q000096:biosynthesis; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D008074:Lipoproteins / Q000096:biosynthesis*; D008565:Membrane Proteins / Q000096:biosynthesis*; D009154:Mutation; D010455:Peptides / Q000494:pharmacology; D011498:Protein Precursors / Q000096:biosynthesis; D012486:Salmonella typhimurium / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D008074:Lipoproteins; D008565:Membrane Proteins; D010455:Peptides; D011498:Protein Precursors; C017339:globomycin