Distribution of fibronectin in normal and diseased human kidneys.
The distribution of fibronectin in 42 renal biopsies was investigated using an indirect immunoperoxidase technique on paraffin sections of formalin-fixed material. Biopsies were obtained from normal human kidneys and from patients with a variety of glomerular disorders. In normal glomeruli, fibronectin was present in Bowman's capsule, in the mesangium, and outlining peripheral capillary loops. A significant increase in fibronectin was observed in most types of glomerulopathy with a distribution closely related to the histopathological diagnosis. Fibronectin was diminished or absent in segmental scars, old diabetic nodules, and hyalinised glomeruli.
D003928:Diabetic Nephropathies / Q000378:metabolism; D005353:Fibronectins / Q000032:analysis*; D005921:Glomerulonephritis / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D007674:Kidney Diseases / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000032:analysis*
D005353:Fibronectins