Organized nerve culture. II. DNA synthesis in Schwann cells in the presence of M. leprae.
Schwann cells that contain M. leprae fail to incorporate DNA precursor, indicating blockage of DNA synthesis. Such a block could lead to no proliferation of Schwann cells, an essential requirement for successful association with axons and consequent myelination.
D000818:Animals; D046508:Culture Techniques; D004247:DNA / Q000096:biosynthesis*; D005727:Ganglia, Spinal / Q000166:cytology / Q000382:microbiology; D007918:Leprosy / Q000378:metabolism*; D008938:Mitosis; D009166:Mycobacterium leprae; D014176:Protein Biosynthesis; D012583:Schwann Cells / Q000378:metabolism* / Q000382:microbiology
D004247:DNA