Mutagenicity of substituted (o-phenylenediamine)platinum dichloride in the Ames test. A quantitative structure-activity analysis.
A set of 13 substituted (o-phenylenediamine)platinum dichlorides has been studied in the  Ames test using Salmonella typhimurium (TA-92). These cis-platinum compounds are mutagenic without activation by microsomes. The following correlation equation shows that the most important determinant of mutagenicity by substituents (X) is electron withdrawal via through resonance: log 1/C = 2.23 sigma sigma minus + 5.78. C in this expression is the molar concentration of compound producing 30 mutations/10(8) bacteria initially delivered above background mutation, and sigma minus is the Hammett constant obtained from substituted anilines.
D000818:Animals; D066298:In Vitro Techniques; D008861:Microsomes / Q000378:metabolism; D009153:Mutagens; D010655:Phenylenediamines / Q000633:toxicity; D010984:Platinum / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013329:Structure-Activity Relationship
D009153:Mutagens; D010655:Phenylenediamines; D010984:Platinum