Metabolic effects of long-term diversion of renal venous blood into the portal system.
In seven splenectomised dogs a left renal vein-splenic vein anastomosis was performed and the right kidney removed. Eighteen to twenty-four months after portalisation of renal venous blood no significant alterations of liver function tests were found. Long-term diversion of renal venous blood into the liver was followed by a slight increase of creatinine and 25(OH)D3, a decrease of alpha-amino acid nitrogen in blood plasma and of plasma renin activity in peripheral blood, by symptoms of slight carbohydrate intolerance despite hyperinsulinaemia and a slight decrease of erythrocytosis. No influence of this procedure on plasma proteins, lipids, electrolytes, aldosterone and cortisol was observed. No morphological abnormalities in liver and kidney tissues were found.
D000818:Animals; D002112:Calcifediol; D003404:Creatinine / Q000097:blood; D004285:Dogs; D005260:Female; D006887:Hydroxycholecalciferols / Q000097:blood; D008099:Liver / Q000378:metabolism* / Q000502:physiology; D008297:Male; D009392:Nephrectomy; D009584:Nitrogen / Q000097:blood; D011170:Portasystemic Shunt, Surgical; D012083:Renin / Q000097:blood; D013156:Splenectomy; D013164:Splenorenal Shunt, Surgical
D006887:Hydroxycholecalciferols; D003404:Creatinine; D012083:Renin; D009584:Nitrogen; D002112:Calcifediol