Synthesis, crystallization and properties of acetyl phenylalanyl lysine chloromethyl ketone: a potential inhibitor of serine proteases.
A procedure for the synthesis of acetyl phenylalanyl lysine chloromethyl ketone is described. The chloromethyl ketone derivative is a noncompetitive inhibitor of trypsin (Ki = 5.9 x 10(-3) M).
D000590:Amino Acid Chloromethyl Ketones / Q000138:chemical synthesis* / Q000494:pharmacology; D007700:Kinetics; D008722:Methods; D011480:Protease Inhibitors; D012697:Serine Endopeptidases; D014361:Trypsin Inhibitors / Q000494:pharmacology
D000590:Amino Acid Chloromethyl Ketones; D011480:Protease Inhibitors; D014361:Trypsin Inhibitors; C025024:acetylphenyl-alanyl-lysine chloromethyl ketone; D012697:Serine Endopeptidases