Activation of the renal pressure system following severe hypotension and its pathophysiologic significance.
The renin activity of the juxtaglomerular apparatus following a period of 210 min of hemorrhagic hypotension was correlated with the blood volume retransfused in order to maintain a hypotensive blood pressure of 30 mm Hg. In an additional experiment the renin activity of the juxtaglomerular apparatus was measured in acute renal failure due to renal artery occlusion over 60 min. The increased renin activity after hemorrhagic hypotension indicates that the renin-angiotensin system contributes to pressure stabilization. The similar rise of the juxtaglomerular renin activity in hypotension as well as in renal artery occlusion suggests the active role of the renin-angiotensin system in acute renal failure following severe hemorrhagic hypotension.
D058186:Acute Kidney Injury / Q000503:physiopathology; D000818:Animals; D007606:Juxtaglomerular Apparatus / Q000503:physiopathology*; D008297:Male; D051381:Rats; D012083:Renin / Q000378:metabolism*; D012771:Shock, Hemorrhagic / Q000503:physiopathology*
D012083:Renin