Effects of insulin and gastro-intestinal hormones on feeding and plasma insulin levels in sheep.
Infusions of the following hormones were made into the hepatic vein of sheep over periods of three hours: pentagastrin (2.1, 5.0 or 9.9 micrograms/kg), pancreozymin (1.0 units/kg), secretin (2.0 units/kg), insulin (2.1 or 4.3 units/kg). Intake of the concentrate food was depressed by pentagastrin at 9.9 micrograms/kg/3 hr (P < 0.05) and increased by insulin at 4.3 units/kg/3 hr-(P < 0.05) Insulin levels in jugular plasma were unaffected by any of the gut hormone infusions. The liver is suggested as being involved in the control of food intake in sheep.
D000818:Animals; D002369:Castration; D002766:Cholecystokinin / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects*; D007328:Insulin / Q000097:blood / Q000494:pharmacology*; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D012633:Secretin / Q000494:pharmacology*; D012756:Sheep
D007328:Insulin; D012633:Secretin; D002766:Cholecystokinin; D010418:Pentagastrin