Comparative studies of the antilipolytic effect of insulin and adenosine in the perifused isolated fat cell.
Insulin and adenosine are both antilipolytic when studied in the epinephrine-stimulated perifused isolated fat cell. Submaximal combinations of insulin plus adenosine are additive but not synergistic. The polypeptide hormone insulin produces an antilipolytic effect which manifests itself as a "lag" in restoration of epinephrine-stimulated lipolysis after removal of the insulin. No such lag is observed with the non-peptide, small molecular weight adenosine. Herein, we demonstrate the antilipolytic effect of two distinct, physiologically important agents in the perifused isolated fat cell.
D000241:Adenosine / Q000494:pharmacology*; D000273:Adipose Tissue / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D004837:Epinephrine / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology*; D007700:Kinetics; D008066:Lipolysis / Q000187:drug effects*; D008297:Male; D010477:Perfusion; D051381:Rats
D007328:Insulin; D000241:Adenosine; D004837:Epinephrine