Protection of mice against group B Streptococcus type Ia by IgG components of a rabbit antiserum.
IgG fractions were separated by ion exchange chromatography on DEAE-cellulose from hyperimmune rabbit sera prepared against a group B streptococcus type Ia mouse-virulent strain. 50 microgram IgG in conjunction with ampicillin (200 mg/kg) protected mice more effectively against a lethal challenge than ampicillin (400 mg/kg) alone or ampicillin (200 mg/kg) combined with gentamicin (10 mg/kg), when administered up to 12 h after infection.
D000667:Ampicillin / Q000627:therapeutic use; D000818:Animals; D002848:Chromatography, DEAE-Cellulose; D005260:Female; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000276:immunology* / Q000302:isolation & purification; D051379:Mice; D011817:Rabbits / Q000276:immunology; D013290:Streptococcal Infections / Q000517:prevention & control*; D013292:Streptococcus agalactiae / Q000276:immunology
D007074:Immunoglobulin G; D000667:Ampicillin