Endotoxin-inactivating potency of hydrogen peroxide: effect on cell growth.
An in vitro system was used to study the detoxifying potential of H2O2 on bacterial endotoxin. L929 fibroblasts were exposed to H2O2-treated and -untreated endotoxin. Growth and viability assays were made at 24, 48, 72, and 96 h. The cultures exposed to H2O2-treated endotoxin showed a normal growth rate, whereas the cultures exposed to untreated endotoxin displayed a substantial reduction in growth. Implications are presented as to the potential role of H2O2 in the pathogenesis and treatment of periodontal disease.
D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004731:Endotoxins / Q000037:antagonists & inhibitors*; D004926:Escherichia coli; D005347:Fibroblasts / Q000187:drug effects; D006861:Hydrogen Peroxide / Q000494:pharmacology*
D004731:Endotoxins; D006861:Hydrogen Peroxide