Insulin allergy: differences in the binding of porcine, bovine, and human insulins with anti-insulin IgE.
We investigated in vitro binding of insulins of various species sources (bovine, porcine, and human) with anti-insulin reaginic immunoglobulins (IgE) in 10 patients with systemic insulin allergy and in 5 nonallergic but insulin-resistant cases. Anti-insulin IgE had a higher avidity for bovine compared with porcine insulin in both groups. Avidity for bovine insulin was also significantly higher compared with human or desalanine porcine insulin in the insulin-allergic patients. These observations provide a rationale for using porcine insulin in the treatment of systemic insulin allergy.
D000818:Animals; D000936:Antigen-Antibody Complex; D002417:Cattle; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity; D007073:Immunoglobulin E; D007328:Insulin / Q000627:therapeutic use; D007330:Insulin Antibodies; D013552:Swine; D014581:Urticaria / Q000209:etiology
D000936:Antigen-Antibody Complex; D007328:Insulin; D007330:Insulin Antibodies; D007073:Immunoglobulin E