Pituitary response to luteinizing hormone-releasing hormone during haloperidol-induced hyperprolactinemia.
The effects of a 6-hour infusion with haloperidol on serum prolactin and luteinizing hormone (LH) levels was studied in a group of male subjects. Five hours after starting the infusions, a study of the pituitary responses to LH-releasing hormone (LH-RH) was carried out. Control patients received infusions of 0.9% NaCl solution. During the course of haloperidol infusions, significant hyperprolactinemia was found, together with an abolished pituitary response to LH-RH, as compared with responses of control subjects.
D000818:Animals; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D010902:Pituitary Gland / Q000378:metabolism*; D011388:Prolactin / Q000097:blood*; D011817:Rabbits
D007987:Gonadotropin-Releasing Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D006220:Haloperidol