Neomycin-induced neuromuscular blockade.
The unusual complication of neuromuscular blockade secondary to neomycin absorption is described. The syndrome characterized by acute muscle flaccidity, diaphragmatic breathing, and central nervous system depression presents a potentially fatal situation. Appropriate treatment of this complication includes respiratory assistance and calcium gluconate administration (IV). A review of the pediatric literature reveals 12 previous cases, of which 2 were secondary to urologic procedures.
D002125:Calcium Gluconate / Q000627:therapeutic use; D002675:Child, Preschool; D006801:Humans; D008297:Male; D009355:Neomycin / Q000008:administration & dosage / Q000009:adverse effects*; D009469:Neuromuscular Junction / Q000187:drug effects*; D012131:Respiratory Insufficiency / Q000209:etiology
D009355:Neomycin; D002125:Calcium Gluconate