Factors affecting the absorption of ampicillin administered intramuscularly in dwarf goats.
In nine healthy dwarf goats there were significantly higher serum concentrations of ampicillin after it was injected into the lateral neck muscles than after it was injected into the thigh. During fever, induced with Escherichia coli endotoxin, the rate of absorption of ampicillin from shivering muscles was faster, resulting in significantly higher serum concentrations of the antibiotic than in control non-febrile goats.
D000042:Absorption; D000667:Ampicillin / Q000008:administration & dosage* / Q000097:blood; D000818:Animals; D004731:Endotoxins / Q000633:toxicity; D004926:Escherichia coli; D005260:Female; D006041:Goats / Q000378:metabolism*; D007273:Injections, Intramuscular; D008297:Male; D012768:Shivering
D004731:Endotoxins; D000667:Ampicillin