title: Short-lived mutagen in Salmonella produced by reaction of trichloroacetic acid and dimethyl sulphoxide.
abstract: A chemical reaction occurs when trichloroacetic acid (TCA) is dissolved in dimethyl sulphoxide (DMSO), with the production of a short-lived mutagenic derivative which was detected using the Salmonella/mammalian-microsome plate overlay assay. Other interactions between test chemicals and solvents are discussed. Choice of proper solvents in mutagenicity testing is emphasized.
mesh_terms: D004121:Dimethyl Sulfoxide / Q000378:metabolism*; D005821:Genetic Techniques; D009153:Mutagens; D012486:Salmonella typhimurium / Q000235:genetics; D012997:Solvents / Q000378:metabolism; D014238:Trichloroacetic Acid / Q000378:metabolism*
chemical_list: D009153:Mutagens; D012997:Solvents; D014238:Trichloroacetic Acid; D004121:Dimethyl Sulfoxide