title: Antibacterial action of quinolones on Escherichia coli. IIa. Conditions required for lethality: effect of anaerobiosis, inoculum size and media composition.
abstract: Quinolones with carboxylic or nitroside groups behaved differently in vitro under various physiological conditions tested. CarboxyQ was not active during the lag phase of E. coli and its activity was proportional to the growth rate under anaerobic conditions. NitroQ was immediately active on the cells soon after the inoculum was introduced under similar conditions. High cell density did not change the typical behaviour of these drugs. Only nitroQ was active in nitrogen-free medium while both were inactive in glucose-free medium. Chloramphenicol, reduced the activity of carboxyQ while that of nitroQ was unaffected.
mesh_terms: D000693:Anaerobiosis; D002701:Chloramphenicol / Q000494:pharmacology; D003470:Culture Media; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D011804:Quinolines / Q000494:pharmacology*
chemical_list: D003470:Culture Media; D011804:Quinolines; D002701:Chloramphenicol; D005947:Glucose