title: Long-term high-dose mebendazole for cystic hydatid disease of liver: failure in two cases.
abstract: Mebendazole was given as definitive therapy to four patients with cystic hydatid disease of the liver who were later explored surgically. Viable hydatid material was removed from two patients after continuous therapy with 40 mg/kg/day for eight and three months respectively. The hydatid material was necrotic in the other two patients. This drug appeared to be ineffective as definitive treatment of two of these four patients with established hydatid disease of the liver.
mesh_terms: D000328:Adult; D001562:Benzimidazoles / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D004444:Echinococcosis, Hepatic / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008463:Mebendazole / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D013997:Time Factors
chemical_list: D001562:Benzimidazoles; D008463:Mebendazole