Effect of bacterial metabolic state on vesical mucosal adherence.
14C-labeled Escherichia coli was introduced into acid-treated and intact rabbit bladders in vivo. Live, dead, and metabolically inhibited bacteria displayed similar interaction with the urothelium with and without intact surface mucoprotein. Disruption of the mucoprotein layer by acid reduced the defense potential in each group to a similar degree. Neither active metabolism nor bacterial cell death seems to enhance bacterial adherence to bladder mucosa.
D000268:Adhesiveness; D000818:Animals; D004848:Epithelium / Q000502:physiology; D004926:Escherichia coli / Q000378:metabolism*; D006851:Hydrochloric Acid / Q000494:pharmacology; D008297:Male; D009088:Mucoproteins / Q000378:metabolism; D011817:Rabbits; D001743:Urinary Bladder / Q000502:physiology*
D009088:Mucoproteins; D006851:Hydrochloric Acid