title: [Disorders of immune regulation in psoriasis].
abstract: Immune abnormalities in psoriasis vulgaris are described. Anti-stratum corneum antibodies deposited with C3 have been found in patients with psoriasis. A lot of other immune abnormalities identified in psoriasis: increased serum IgG and IgA levels, lowered DNCB-sensitization, alteration in polymorphnuclear leukocytes (PMN) function, decreased number of T cells, lack of response to concanavalin A (ConA) and an increase in the polyclonal B cell activation. the authors believe that the immunoregulatory defect is due to the disorder of the skin.
mesh_terms: D001323:Autoantibodies / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D003176:Complement C3; D003208:Concanavalin A / Q000276:immunology; D003315:Cornea; D004137:Dinitrochlorobenzene / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000209:etiology*; D008213:Lymphocyte Activation / Q000187:drug effects; D009504:Neutrophils / Q000276:immunology; D011565:Psoriasis / Q000150:complications / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D001323:Autoantibodies; D003176:Complement C3; D004137:Dinitrochlorobenzene; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D003208:Concanavalin A
vernacular_title: Störungen der Immunregulation bei der Psoriasis vulgaris.