[Exhaustibility of beta cells in the aged after repeated stimuli].
Seven aged subjects (mean age 78,5 years) and seven young controls (mean age 23,8 years), all nondiabetics and non-obese, were given intravenous injections of glucose, glucose and arginine, tolbutamide, tolbutamide and glucagon at 30 minutes intervals in order to determine the maximum insulin-secretory capacity of their pancreatic beta-islet cells after intensive stimulation. The response iun the elderly group was less prompt and quantitatively smaller at all stage of the test, but the beta-cells both in aged and in young subjects showed no evidence of exhaustion.
D000328:Adult; D000367:Age Factors; D000368:Aged; D001120:Arginine / Q000494:pharmacology; D005934:Glucagon / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000502:physiology*; D014044:Tolbutamide / Q000494:pharmacology
D007328:Insulin; D005934:Glucagon; D001120:Arginine; D014044:Tolbutamide; D005947:Glucose
Ricerche sulla esauribilità della beta-cellula nell'anziano dopo stimoli ripetuti.