title: Organized nerve culture. II. DNA synthesis in Schwann cells in the presence of M. leprae.
abstract: Schwann cells that contain M. leprae fail to incorporate DNA precursor, indicating blockage of DNA synthesis. Such a block could lead to no proliferation of Schwann cells, an essential requirement for successful association with axons and consequent myelination.
mesh_terms: D000818:Animals; D046508:Culture Techniques; D004247:DNA / Q000096:biosynthesis*; D005727:Ganglia, Spinal / Q000166:cytology / Q000382:microbiology; D007918:Leprosy / Q000378:metabolism*; D008938:Mitosis; D009166:Mycobacterium leprae; D014176:Protein Biosynthesis; D012583:Schwann Cells / Q000378:metabolism* / Q000382:microbiology
chemical_list: D004247:DNA