Evidence that ionization of zinc-bound water regulates the anion-binding capacity of the coenzyme-binding site in liver alcohol dehydrogenase.
D015082:2,2'-Dipyridyl / Q000378:metabolism; D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000818:Animals; D000838:Anions; D001665:Binding Sites; D006736:Horses; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000494:pharmacology; D008099:Liver / Q000201:enzymology*; D009243:NAD / Q000031:analogs & derivatives / Q000378:metabolism*; D011487:Protein Conformation; D014867:Water / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism*
D000838:Anions; D007093:Imidazoles; D014867:Water; D009243:NAD; D015082:2,2'-Dipyridyl; D000429:Alcohol Oxidoreductases; D015032:Zinc