title: A sophisticated programmable miniaturised pump for insulin delivery.
abstract: We have conceived a truly pre-programmable infusion system usable for intravenous administration of insulin in diabetic subjects. The original system has been built into a small, commercially available, syringe-pump of which only the case and the mechanical parts have been kept. The computing until has a timer, a programmable memory of 512 words by 8 bits and a digital-to-frequency converter to run the motor which drives the syringe. The memory contains 8 profiles of insulin injections stored in digital form over 64 words. Each profile is selected by the patient before eating according to the carbohydrate content of the planned meal and last about two hours, starting from and returning to the basal rate of insulin, at which it remains until next profile selection. Amount, profiles and duration of insulin injection are either mean values deduced from previous studies with a closed-loop artificial pancreas or personally fitted values; they are stored in an instantly replaceable memory cell. This device allows the patient to choose the time, nature and amount of his food intake.
mesh_terms: D003201:Computers; D003920:Diabetes Mellitus / Q000188:drug therapy*; D006801:Humans; D007263:Infusions, Parenteral / Q000295:instrumentation* / Q000379:methods; D007328:Insulin / Q000008:administration & dosage*; D012651:Self Medication
chemical_list: D007328:Insulin