title: Stimulation of phagocytic activity of neutrophilic granulocytes by sera of patients with solid tumors.
abstract: The effect of serum of patients with solid tumors on the phagocytic activity of normal neutrophilic granulocytes was investigated. The largest groups of tumors studied were carcinoma of colon/rectum, sarcomas and melanomas. Sera from all three groups of patients were found to have highly significant (p < 0.001) stimulatory effects on granulocyte phagocytic activity. These findings contrast with previously reported depression of granulocyte phagocytic activity associated with various forms of leukemia and lymphomas.
mesh_terms: D002986:Clinical Trials as Topic; D003110:Colonic Neoplasms / Q000097:blood; D006801:Humans; D008545:Melanoma / Q000097:blood; D009369:Neoplasms / Q000097:blood*; D009504:Neutrophils / Q000502:physiology*; D010587:Phagocytosis; D012004:Rectal Neoplasms / Q000097:blood; D012509:Sarcoma / Q000097:blood