[Cross-reacting antigen common to cells of the basal layer of monolayer epithelium and the polysaccharide of group A streptococci during embryogenesis].
Indirect immunofluorescence with the use of antibodies to the cross-reactive antigen (CRA) common to the group A streptococcus as well as to human and animal cover epithelia of ectodermal origin has shown that CRA appears in the Wistar rat fetal skin on the 15th day of pregnancy in the early period of stratified squamous epithelium formation. The antigen is diffusely spreading in the cytoplasm of large cells of the embryonal skin epithelium. By the end of pregnancy and at the moment of birth (days 21--23) the pattern of CRA localization in fetal skin is the same as the skin of adult species: it is localized only in the peripheral zone of basal layer cell cytoplasm of the stratified squamous epithelium.
D000818:Animals; D000831:Animals, Newborn; D000941:Antigens / Q000032:analysis*; D000942:Antigens, Bacterial / Q000032:analysis; D003429:Cross Reactions; D005455:Fluorescent Antibody Technique; D051381:Rats / Q000196:embryology; D012867:Skin / Q000276:immunology*; D013297:Streptococcus pyogenes / Q000276:immunology*
D000941:Antigens; D000942:Antigens, Bacterial
Perekrestno reagiruiushchiĭ antigen, obshchiĭ dlia kletok bazal'nogo sloia mnogosloĭnogo épiteliia i polisakharida streptokokka gruppy A v émbriogeneze.