Growth hormone cell antibodies and partial growth hormone deficiency in a girl with Turner's syndrome.
Growth hormone (GH) cell auto-antibodies have been demonstrated in the serum of a girl with an iso-chromosome variant of Turner's syndrome. On two occasions she showed an abnormal response of GH release during insulin induced hypoglycaemia. Her response to GH treatment was poor, but this was commenced at a very late bone-age. It is possible that autoimmunity is a new aetiological factor for GH deficiency in some cases.
D000293:Adolescent; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D005455:Fluorescent Antibody Technique; D013006:Growth Hormone / Q000172:deficiency / Q000276:immunology* / Q000627:therapeutic use; D006801:Humans; D010903:Pituitary Gland, Anterior / Q000276:immunology; D014424:Turner Syndrome / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism
D001323:Autoantibodies; D013006:Growth Hormone