Central oscillators responsible for sympathetic nerve discharge.
The current state of knowledge concerning central mechanisms responsible for the generation of background discharges in sympathetic nerves is examined. It is apparent from recent investigations that the classic concept of a randomly discharging and diffusely organized central network onto which rhythms (cardiac- and respiratory-related) are imposed by extrinsic inputs has not passed the test of time. Rather, brain stem as well as spinal networks that govern the discharges of sympathetic nerves are inherently capable of rhythm generation. Sympathetic nerve rhythms inherent to the central nervous system imply the existence of neuronal circuits that are capable of oscillatory activity. Central oscillators provide a mechanism for synchronization of the activity of populations of sympathetic neurons in the absence of periodic input from sources extrinsic to the central nervous system. Indeed, the thesis is developed that, rather than creating rhythms in sympathetic nerve discharge, the function of periodic input from extrinsic sources such as the baroreceptors is to entrain rhythms of central origin. Finally, the problems associated with the identification of neuronal types that comprise central oscillators which govern the discharges of sympathetic nerves are discussed.
D000200:Action Potentials; D000818:Animals; D001931:Brain Mapping; D001933:Brain Stem / Q000502:physiology*; D002415:Cats; D004558:Electric Stimulation; D006321:Heart / Q000502:physiology; D006339:Heart Rate; D011311:Pressoreceptors / Q000502:physiology*; D012018:Reflex / Q000502:physiology*; D012119:Respiration; D013564:Sympathetic Nervous System / Q000502:physiology*; D013997:Time Factors; D014630:Vagus Nerve / Q000502:physiology