Fimbrin, a new microfilament-associated protein present in microvilli and other cell surface structures.
A 68,000 mol wt polypeptide has been identified as one of the few major proteins in the microfilament bundles of the microvilli present on intestinal epithelial cells. Antibodies against the purified protein have been used in indirect immunofluorescence microscopy on several cultured cells. The protein have been used in indirect immunofluorescence microscopy on several cultured cells. The protein is found particularly prominent in membrane ruffles, microspikes, and microvilli.
D000199:Actins / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000648:ultrastructure*; D002645:Chickens; D003599:Cytoskeleton / Q000378:metabolism* / Q000648:ultrastructure; D004591:Electrophoresis, Polyacrylamide Gel; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D007413:Intestinal Mucosa / Q000648:ultrastructure; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D008840:Microfilament Proteins; D008871:Microvilli / Q000378:metabolism / Q000648:ultrastructure*; D008970:Molecular Weight
D000199:Actins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D008840:Microfilament Proteins; C026742:plastin