[Autoimmune hemolytic anemia anemia followed by acute granulocytic leukemia (author's transl)].
The authors report a case of acute myeloid leukemia developping 5 years after the onset of an autoimmune hemolytic anemia. The cytological origin of the proliferation is difficult to assess: the presence of prominent membranous complexes and a strong positivity of acid phosphatase reaction favour its megacaryocytic origin. However the cytological evolution pleads for the development of successive clones of monocytic origin, may be modified by the treatment. Are the two diseases successive consequences of preexisting state of immunodepression or was such a state created by the autoimmune anemia?
D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications*; D001773:Blood Cells / Q000201:enzymology / Q000502:physiology / Q000648:ultrastructure; D001853:Bone Marrow / Q000201:enzymology / Q000648:ultrastructure; D001854:Bone Marrow Cells; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000201:enzymology / Q000473:pathology; D008297:Male; D010544:Peroxidases / Q000378:metabolism; D010587:Phagocytosis
D010544:Peroxidases
Anémie hémolytique à auto-anticorps suivie d'une leucémie myéloïde aiguë.