[Role of 5-alpha-androstane-3-beta, 17-beta-diol in establishing feedback between the gonads and hypothalamo-hypophyseal system of orchidectomized adult rats].
Concentration of luteinizing hormone and content of luliberine were estimated, respectively, blood serum and in hypothalamic arccuate nucleus and median eminence of adult castrated rats after administration of testosterone, 5 alpha-androstane 3 beta, 17 beta diol and 5 alpha-androstane 3 alpha, 17 beta diol. Effect of testosterone and of its derivatives on hypothalamo-hypophysial system was distinctly dissimilar both in the intensity of the action and in the rate of its realization. 5 alpha-androstane 3 beta, 17 beta diol as well as testosterone and 5 alpha-androstane 3 alpha, 17 beta diol were shown to be active in the negative feedback mechanism between gonads and hypothalamo-hypophysial system; the effect of androgenes was dose-dependent.
D015113:Androstane-3,17-diol / Q000008:administration & dosage / Q000494:pharmacology*; D000732:Androstanols / Q000494:pharmacology*; D000818:Animals; D002369:Castration; D004305:Dose-Response Relationship, Drug; D005246:Feedback; D007987:Gonadotropin-Releasing Hormone / Q000032:analysis*; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D007031:Hypothalamus / Q000032:analysis; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D008473:Median Eminence / Q000032:analysis; D051381:Rats; D013739:Testosterone / Q000494:pharmacology; D013997:Time Factors
D000732:Androstanols; D015113:Androstane-3,17-diol; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone
Rol' 5 alpha-androstan-3 beta, 17 beta-diola v osushchestvlenii obratnoĭ sviazi mezhdu gonadami i gipotalamo-gipofizarnoĭ sistemoĭ orkhidéktomirovannykh vzroslykh krys.