title: Inhibition of renin secretion by HCl is related to chloride in both dog and rat.
abstract: To determine if inhibition of renin release by HCl is related to acidosis or to Cl-, the effects of peripheral venous infusions of HCl and H2SO4 on plasma renin activity (PRA) were compared in the dog and the rat. In NaCl-deprived, pentobarbital-anesthetized dogs, either 0.15 M HCl (n = 10) or 0.075 M H2SO4 (n = 7) was infused for 60 min. In 5 of the 10 HCl-infused dogs (group A), urine Cl- excretion increased (P less than 0.01) during HCl infusion. In the remaining five dogs (group B), Cl- excretion did not increase. Cl- excretion also did not increase during H2SO4 infusion. Comparable acidosis was produced in all three groups. PRA decreased (P less than 0.01) in response to HCl in group A but did not change (P greater than 0.8) in group B HCl-infused dogs or in H2SO4-infused dogs. In NaCl-deprived, anesthetized rats, PRA was suppressed (P less than 0.05) by HCl (from 40.6 +/- 9.4 to 27.4 +/- 5.3 ng . ml-1 . h-1 (SE)) but not H2SO4 (from 37.1 +/- 4.2 to 37.0 +/- 6.3 ng . ml-1 . h-1), despite comparable acidosis. Cl- excretion increased only in HCl-infused rats. In conclusion, inhibition of PRA by acute infusion of HCl is specifically related to Cl-.
mesh_terms: D000818:Animals; D002712:Chlorides / Q000652:urine; D003404:Creatinine / Q000652:urine; D004285:Dogs / Q000502:physiology*; D006851:Hydrochloric Acid / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism*; D011188:Potassium / Q000652:urine; D051381:Rats / Q000502:physiology*; D012083:Renin / Q000097:blood / Q000378:metabolism*; D012964:Sodium / Q000652:urine; D013464:Sulfuric Acids / Q000494:pharmacology
chemical_list: D002712:Chlorides; D013464:Sulfuric Acids; D012964:Sodium; D003404:Creatinine; D012083:Renin; D006851:Hydrochloric Acid; D011188:Potassium