[Renewal of bronchial and pulmonary cells: a comprehensive review of recent information (author's transl)].
In the bronchi, the ultrastructural findings allow a schema to be established of proliferation-differentiation of basal cells, undifferentiated cells and mucus cells. In the bronchioles, the Clara cells or an immediate progenitor seem at the same time to play the role of stem cell for ciliated cells, mucus cells and brush cells. Same observations suggest that the bronchial and bronchiolar stem cells may produce neuro-secretary cells; the increase in neuro-secretary cells is a common enough phenomenon under the influence of numerous stimuli. No evidence of neuro-secretory cells dividing was observed. The histology and the kinetics of the cell population of bronchus associated lymphoid tissue (BALT) are reviewed. In the parenchyma, the role of the pneumocyte in restoring epithelial cells to high concentrations of oxygen is also discussed. Throughout the literature and also in the authors' experience, attention is drawn to the lack of correlation between the inflammation cell septal infiltrate and the endo-alveolar population. The cytokinetics of the alveolar macrophages (MA) are reviewed and recent findings discussed, including the absence of maintained cell division of the MA, the recruitment of young cells, the heterogenous distribution in the tissues of actively mitotic macrophages and the role of chemotactic factors.
D000535:Aluminum / Q000494:pharmacology; D000818:Animals; D001608:Beryllium / Q000494:pharmacology; D001980:Bronchi / Q000502:physiology* / Q000648:ultrastructure; D004848:Epithelium / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D008168:Lung / Q000502:physiology* / Q000648:ultrastructure; D008214:Lymphocytes / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D008854:Microscopy, Electron; D051381:Rats; D012038:Regeneration; D013936:Thymidine / Q000494:pharmacology
D000535:Aluminum; D001608:Beryllium; D013936:Thymidine
Renouvellement des cellules des bronches et du poumon. Analyse des données récentes.