Induction of implantation by androgens in mice with delayed implantation.
Testosterone and 5 alpha-dihydrotestosterone (5 alpha-DHT) were able to mimic the action of oestradiol-17 beta in initiating implantation in ovariectomized, progesterone-treated mice. Cyproterone acetate and CI-628 were capable of inhibiting the testosterone-induced response, but CI-628 citrate prevented only the 5 alpha-DHT-mediated implantation reaction. It is suggested that testosterone acts through testosterone and oestrogen receptors while 5 alpha-DHT acts only through oestrogen receptors.
D000818:Animals; D002369:Castration; D003534:Cyproterone / Q000494:pharmacology; D013196:Dihydrotestosterone / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010064:Embryo Implantation / Q000187:drug effects*; D010065:Embryo Implantation, Delayed / Q000187:drug effects*; D005260:Female; D051379:Mice; D009594:Nitromifene / Q000494:pharmacology; D011374:Progesterone / Q000494:pharmacology; D013739:Testosterone / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D013196:Dihydrotestosterone; D013739:Testosterone; D011374:Progesterone; D009594:Nitromifene; D003534:Cyproterone