Postoperative vomiting treated with domperidone. A double-blind comparison with metoclopramide and a placebo.
In a double-blind comparison of domperidone 10 mg, domperidone 4 mg, metoclopramide 10 mg and a placebo, 176 adult patients were given an intravenous injection of one of these substances after postoperative vomiting had occurred. Patients were then observed for 6 hours. Those who failed to respond sufficiently to the double-blind injection were given an open dose of domperidone 4 mg i.v. Vomiting recurred in 52% of patients in each of domperidone groups compared with 75% of patients in the metoclopramide group and 84% of patients in the placebo group. Thus domperidone was significantly more effective than the other two substances (p < 0.05). Significantly more patients in the placebo group required a supplementary injection than in the domperidone and metoclopramide groups (p < 0.05). No side effects were observed in any patient.
D000328:Adult; D000368:Aged; D000932:Antiemetics / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004294:Domperidone; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use*; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use*; D010919:Placebos; D011183:Postoperative Complications / Q000188:drug therapy*; D014839:Vomiting / Q000188:drug therapy* / Q000209:etiology
D000932:Antiemetics; D001562:Benzimidazoles; D010880:Piperidines; D010919:Placebos; D004294:Domperidone; D008787:Metoclopramide