[Inhibitory action of adrenaline on the antiaggregation activity of the arterial wall].
It has been shown in experiments on Wistar rats that adrenaline inhibits both in vitro and in vivo the capacity of the arterial wall for synthesizing an antiaggregating substance (prostacycline). It is suggested that adrenaline takes a direct part in body thrombogenesis during emotional stress and in conditions associated with the increased catecholamine output in the blood.
D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology*; D011464:Epoprostenol / Q000096:biosynthesis; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D011448:Prostaglandin Antagonists; D051381:Rats; D013927:Thrombosis / Q000209:etiology; D013997:Time Factors
D011448:Prostaglandin Antagonists; D011464:Epoprostenol; D004837:Epinephrine
Ingibiruiushchee deĭstvie adrenalina na antiagregatsionnuiu aktivnost' stenki arteriĭ.