title: [Proximal nail fold biopsy in connective tissue diseases. 26 cases studied under light and electron microscopy and direct immunofluorescence (author's transl)].
abstract: 30 specimens of nail fold biopsies have been studied through light and electron microscopy, and direct immunofluorescence, in 26 cases of connective tissue diseases: Raynaud's phenomenon and acrosclerosis (7 cases), systemic scleroderma (10 cases), chronic and acute lupus erythematosus (4 cases), dermatomyositis (5 cases). Numerous tissular changes have been observed by these three different ways: capillaries dilatations, dermal sclerosis, numerous, large, dermal and epidermal colloid bodies, basal lamina replications, collagen's modifications, tubuloreticular inclusions, crystalloid bodies, lysosomial inclusions, immunoglobulins deposits. Thus proximal nail fold appears to be an elective tissular area for collagen diseases study.
mesh_terms: D002196:Capillaries; D003095:Collagen Diseases / Q000473:pathology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D008854:Microscopy, Electron; D009262:Nails; D012867:Skin / Q000098:blood supply / Q000473:pathology / Q000648:ultrastructure*
vernacular_title: La biopsie du repli sus-unguéal dans les malsdies dites du collagéne. Etude histologique, ultrastructurale et en immunofluorescence de 26 cas.