[Carbohydrate tolerance and serum insulin in hypertension].
The glycemic and insulinemic curves were followed up in 20 patients with hypertonic disease during the standard oral glucose-tolerance test. Normal glucose-tolerance (NGT) was found in 55%, suspected pathological (SPGT)--in 25% and pathological (PGT)--in 20%. Hypertonics have higher, later reaching its maximum and more prolonged insulin secretion. Normal or borderline normal glucose tolerance is maintained owing to the higher capacity of insulin secretion as compared with the control subjects. Glucose tolerance becomes pathological with the decrease or exhaustion of insulogenic index under that of the control subjects. The elevated blood sugar levels in patients with SPGT and PGT, accompanied with relative (statistically insignificant) hyperinsulinemia in the patients with NGT and PGT and statistically significant in patients with SPGT provide conditions for the enhancement of endogenous synthesis of triglycerides, related to atherogenesis. An opinion is expressed that: I. The hypertonic patients are threatened with atherosclerosis advancement not only by the effect of the increased vascular tone upon that process but also by the enhancement of triglyceride synthesis; 2. Hypertonic disease could be considered a risk factor in the origination of diabetes mellitus.
D000328:Adult; D001161:Arteriosclerosis / Q000209:etiology; D001786:Blood Glucose / Q000032:analysis*; D003920:Diabetes Mellitus / Q000209:etiology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D012306:Risk
D001786:Blood Glucose; D007328:Insulin
Vŭglekhidraten tolerans i serumen insulin pri khipertonichna bolest.