[Application of a test of cellular fusion in Creutzfeldt-Jakob and Alzheimer diseases (author's transl)].
We have tested the in vitro cellular fusing activity of brain suspensions from the following categories of patients: CJD (53 cases), Alzheimer (23 cases), and non-neurological controls (25 cases). CSF specimens were also available for 26 of the CJD patients. Our results show that 65-75 per cent of CJD brain specimens induce cell fusion but that this activity is only rarely reflected in matched CSF specimens. Among other types of degenerative neurological diseases, a sharp distinction appeared between familial Alzheimer disease, which caused fusion at nearly the same frequency as CJD, and sporadic Alzheimer disease, which was not significantly different from the non-neurological control specimens. The biological and clinical significance of these results are discussed.
D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000503:physiopathology*; D002459:Cell Fusion; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis / Q000503:physiopathology*; D003704:Dementia / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
Application d'un test de fusion cellulaire aux maladies de Creutzfeldt-Jakob et d'Alzheimer.