[Glycosylated hemoglobins and erythrocyte 2,3-diphosphoglycerate in diabetes mellitus].
Investigations carried out on 43 diabetic not ketoacidotic patients (32 women and 11 men) showed that the percentage of glycosylated hemoglobins (GHb) is significantly (p less than 0.01) inversely related to the intra-erythrocytic concentration of 2,3-DPG and to the calculated P50. Preliminary data from a prospective study suggest that the inverse relationship could be referred to the degree of control of the disease. In poorly controlled diabetes, where at the highest percentages of GHb the lowest levels of 2,3-DPG are found, less oxigen can be delivered to peripheral tissues.
D019794:2,3-Diphosphoglycerate; D000293:Adolescent; D000328:Adult; D000368:Aged; D003920:Diabetes Mellitus / Q000097:blood* / Q000628:therapy; D003927:Diet, Diabetic; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004912:Erythrocytes / Q000032:analysis*; D005260:Female; D006027:Glycosides / Q000032:analysis*; D006441:Hemoglobin A / Q000031:analogs & derivatives* / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
D004163:Diphosphoglyceric Acids; D006027:Glycosides; D007004:Hypoglycemic Agents; D007328:Insulin; D019794:2,3-Diphosphoglycerate; D006441:Hemoglobin A
Emoglobine glicosilate e 2,3 difosfoglicerato eritrocitario nel diabete mellito.