Effect of tiopronin on senile cataracts. A double-blind clinical study.
The therapeutic effect of tiopronin on incipient senile cataracts was evaluated in 150 cases (275 eyes) by a double-blind study using nonactive placebo. A more favorable tendency to visual acuity was noted in the tiopronin than in the placebo group. The slit-lamp microscopic findings showed a statistically significant difference between the tiopronin and the placebo groups. Integrated judgement revealed tiopronin to be significantly effective as compared with the placebo. A side effect of fever with systemic eruption was observed in 1 case in the tiopronin group but disappeared completely when administration of the drug was discontinued.
D000367:Age Factors; D000368:Aged; D000603:Amino Acids, Sulfur / Q000627:therapeutic use*; D002386:Cataract / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008625:Tiopronin / Q000627:therapeutic use*
D000603:Amino Acids, Sulfur; D008625:Tiopronin