title: Chronic lathyrism. Plasma, aorta and rat skin treated for five months with beta-aminopropionitrile with or without high fat diet.
abstract: Previous experiments proved that white Wistar rats, resistant to spontaneous or experimental atheroma, present arteriosclerosis (parietal aorta lesions) and atheroma lesions (fat deposits) after a 9 week-treatment by Beta-aminopropionitrile (BAPN) followed by a high fat diet. The present work shows that BAPN alone, administered for 5 months, does not induced atheroma; its formation needs both lipid humoral disorders and parietal aortic lesions. It confirms certain facts noted in the aging of man and in the formation of atheroma.
mesh_terms: D000629:Aminopropionitrile / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000032:analysis / Q000473:pathology; D001808:Blood Vessels / Q000473:pathology*; D002784:Cholesterol / Q000032:analysis / Q000097:blood*; D002908:Chronic Disease; D004041:Dietary Fats / Q000008:administration & dosage*; D007842:Lathyrism / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051381:Rats; D012867:Skin / Q000032:analysis*
chemical_list: D004041:Dietary Fats; D000629:Aminopropionitrile; D002784:Cholesterol