Biotin regulatory (bir) mutations of Escherichia coli.
Most mutants selected for derepression of the biotin operon required elevated concentrations of biotin for growth. Mutant extracts were deficient in holoenzyme synthetase activity.
D001059:Apoproteins / Q000378:metabolism; D001710:Biotin / Q000096:biosynthesis* / Q000378:metabolism / Q000494:pharmacology; D019731:Carbon-Nitrogen Ligases; D004926:Escherichia coli / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D005809:Genes, Regulator; D008025:Ligases / Q000378:metabolism; D009154:Mutation; D012097:Repressor Proteins / Q000096:biosynthesis
D001059:Apoproteins; D012097:Repressor Proteins; D001710:Biotin; D008025:Ligases; D019731:Carbon-Nitrogen Ligases; C023312:holocarboxylase synthetases