Anti-cancer action of retinoids.
The anti-cancer action of retinyl acetate (Vitamin-A acetate, VAA), chosen as a representative retinoid substance, is attributed to its power to exercise immunopotentiation, though other possibilities are considered. The reasons for forming this opinion were: (1) chronic administration of VAA brought about enlargement of the thymus and peripheral lymph nodes; (2) the administration of VAA curtailed the life of skin allografts though (3) its action could be reversed by the concomitant administration of immunosuppressive agents.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D007114:Immunization; D008221:Lymphoid Tissue / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000517:prevention & control*; D009929:Organ Size / Q000187:drug effects; D016038:Skin Transplantation; D014184:Transplantation, Homologous; D014801:Vitamin A / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000627:therapeutic use
D000961:Antilymphocyte Serum; D014801:Vitamin A