Amino-alpha-carbolines as mutagenic agents in cigarette smoke condensate.
Two mutagenic agents, 2-amino-9H-pyrido[2,3-b)indole and 2-amino-3-methyl-9H-pyrido[2,3-b]indole (amino-alpha-carbolines) have been isolated from cigarette smoke condensate for this study. The former agent varied in amounts from a low of 25 ng/cigarette in the smoke of flue-cured tobacco, to a high of 258 ng/cigarette in a cigarette of Japanese domestic variety. The latter ranged in amounts from 9 to 37 ng/cigarette. The contents of these mutagens in the smoke condensate were positively related to an increase in mutagenic activity of Salmonella typhimurium TA 98.
D002243:Carbolines / Q000032:analysis / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007211:Indoles / Q000494:pharmacology*; D013058:Mass Spectrometry; D009152:Mutagenicity Tests; D009153:Mutagens; D010947:Plants, Toxic; D012486:Salmonella typhimurium / Q000187:drug effects; D012906:Smoke; D013052:Spectrometry, X-Ray Emission; D014026:Nicotiana
D002243:Carbolines; D007211:Indoles; D009153:Mutagens; D012906:Smoke; C017821:2-amino-3-methyl-9H-pyrido(2,3-b)indole; C017822:2-amino-9H-pyrido(2,3-b)indole