title: Double-blind placebo-controlled studies with flunarizine in venous insufficiency.
abstract: In 4 placebo-controlled double-blind studies of patients suffering from venous insufficiency--defined as the presence of varicose veins combined with a range of subjective symptoms and presence of venous ulcers--flunarizine was statistically significantly superior to placebo in improving symptomatology, reducing the circumference of swollen lower legs and ankles, and increasing the speed of healing of venous ulcers. No side-effects were noted.
mesh_terms: D002936:Cinnarizine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005444:Flunarizine; D006801:Humans; D010879:Piperazines / Q000627:therapeutic use*; D010919:Placebos; D014665:Vasodilator Agents; D014689:Venous Insufficiency / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D010879:Piperazines; D010919:Placebos; D014665:Vasodilator Agents; D002936:Cinnarizine; D005444:Flunarizine