Influence of glucocorticoids on the cellular immune response evoked by an experimental sarcoma in rats.
A test system to evaluate the influence of antineoplastic drugs on the cell-mediated immune response evoked by an experimental rat carcinoma is presented. Thoracic Duct cells from W 49 tumor-bearing WF rats were added to monolayers of 51Cr-labelled tumor cells. A clear cytotoxic effect was noted. In vivo glucocorticoid treatment of rats after tumor inoculation prevented the appearance of such cells. In vivo tumor growth rate was not affected.
D000818:Animals; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects*; D016030:Kidney Transplantation; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology*; D051381:Rats; D011920:Rats, Inbred WF / Q000276:immunology; D012513:Sarcoma, Experimental / Q000276:immunology* / Q000473:pathology; D014181:Transplantation Immunology
D008775:Methylprednisolone