Hidden Thy-1 antigen in a subpopulation of mouse bone marrow cells.
Immunofluorescence and cytolysis studies using antisera against the xeno- and alloantigenic components of the Thy-1 molecule have shown that in adult mouse bone marrow more cells bear the xeno than the alloantigen. Allo+ cells form a subset of a larger, xeno+ population. Xeno+ allo- 'prothymocytes' can be induced to express the alloantigen in vitro; this could result from the unmasking of cryptic antigen, the presence of which is demonstrated, rather than de novo antigen synthesis. Some xeno+ allo- cells are involved in splenic haemopoiesis, either as a subpopulation of precursors, or as accessory helper cells.
D000818:Animals; D001853:Bone Marrow / Q000276:immunology*; D001854:Bone Marrow Cells; D002452:Cell Count; D003114:Colony-Forming Units Assay; D005455:Fluorescent Antibody Technique; D007519:Isoantigens / Q000032:analysis*; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D007519:Isoantigens