Murine pancreatic beta-cells express H-2K and H-2D but not Ia antigens.
Direct microcytotoxicity testing and absorption analyses were employed to determine whether H-2K, H-2D, and Ia antigens are present on murine islet of Langerhans cells. Products of the H-2K and H-2D loci were found on beta-cells from three different mouse strains, but I-region (Ia) antigens were not detected. The absence of Ia gene products from islet cells may be of importance in explaining the survival of islet allografts across major histocompatibility barriers.
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D003602:Cytotoxicity, Immunologic; D005260:Female; D006183:H-2 Antigens / Q000032:analysis*; D007515:Islets of Langerhans / Q000276:immunology*; D007519:Isoantigens / Q000032:analysis*; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice
D000954:Antigens, Surface; D006183:H-2 Antigens; D007519:Isoantigens