Usefulness and limitations of murine tumor models for the identification of new antitumor agents.
Murine tumor systems that have been employed in the identification of most of the known antitumor agents are reviewed and their usefulness and limitations in the identification of new antitumor agents is discussed. A new antitumor screening program has been initiated by the Division of Cancer Treatment, National Cancer Institute which employs human tumors growing in athymic mice. The questions addressed using this screen and representative data are presented.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D010865:Pilot Projects; D014183:Transplantation, Heterologous
D000970:Antineoplastic Agents