Neutrophil chemotaxis defect in IgA deficiency evaluated by migration agarose method.
The chemotactic and random mobility functions of twelve selectively IgA-deficient patients were evaluated by a method using agarose gel. A severe polymorphonuclear cellular chemotactic defect was found in ten out of twelve patients, but only five of them also showed a marked associated impairment of random locomotory function. Furthermore, in one subject, levamisole therapy resulted in a dramatic improvement of both chemotactic and random mobility functions. These results are discussed in the paper with respect to the possible pathogenetic implications.
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000032:analysis / Q000276:immunology; D002465:Cell Movement; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004406:Dysgammaglobulinemia / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006801:Humans; D017098:IgA Deficiency; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007158:Immunologic Techniques; D007958:Leukocyte Count; D007978:Levamisole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D011134:Polysaccharides; D012685:Sepharose; D013601:T-Lymphocytes / Q000032:analysis / Q000276:immunology
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011134:Polysaccharides; D007978:Levamisole; D012685:Sepharose