[Contribution to the study of the phagocytosing ability of broncho-alveolar macrophages in smokers and non-smokers (author's transl)].
Broncho-alveolar macrophages were obtained by bronchial washing from 20 pairs of matched smokers and non-smokers. The following parameters were studied: phagocytosing ability of macrophages on silica in cell culture in the presence or absence of cotinin, a biocompound of nicotin; migration inhibitory factor (MIF), and power and level of alpha 1-antitrypsin in sera of patients. The results are reported as a function of absolute number of macrophages obtained, their viability, the amount of cigarettes smoked, and the action of cotinin. MIF was stronger in the smokers. There was no difference between the groups as far as power and level of alpha 1-antitrypsin are concerned. Cotinin provokes important lesions in the macrophages. The phagocytic power was not significantly different in smokers and non smokers, but the results were better in non-smokers.
D000368:Aged; D001980:Bronchi / Q000166:cytology*; D003367:Cotinine / Q000494:pharmacology; D005260:Female; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000494:pharmacology; D008264:Macrophages / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010587:Phagocytosis / Q000187:drug effects; D011650:Pulmonary Alveoli / Q000166:cytology*; D014029:Tobacco Use Disorder / Q000503:physiopathology*; D000515:alpha 1-Antitrypsin / Q000032:analysis
D008263:Macrophage Migration-Inhibitory Factors; D000515:alpha 1-Antitrypsin; D003367:Cotinine
Contribution à l'étude du pouvoir phagocytaire des macrophages broncho-alvéolaire chez les fumeurs et les non fumeurs.