Role of complement in chemotaxis: study of a localized infection.
A model of Escherichia coli-induced pyelonephritis was used to study the effect of complement depletion in an organ-specific, nonimmunological inflammatory lesion in rats. In this model of a local infection, which can be considered to be nonspecific inflammatory stimulus, the depletion of complement by the administration of a purified cobra venom factor did not alter the course of the disease. There were minor differences when the results from complement-depleted and normocomplementemic animals were compared, but the composition of the inflammatory infiltrate was not greatly altered. Therefore, the presence of C3 and a functional complement system are relatively unimportant factors in determining the characteristics of the inflammatory response in a localized infection-induced lesion.
D000818:Animals; D002634:Chemotaxis, Leukocyte; D003176:Complement C3 / Q000502:physiology*; D003165:Complement System Proteins / Q000502:physiology*; D004906:Erythrocyte Count; D004927:Escherichia coli Infections / Q000276:immunology* / Q000473:pathology; D005260:Female; D007668:Kidney / Q000473:pathology; D007958:Leukocyte Count; D008297:Male; D011704:Pyelonephritis / Q000276:immunology* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D003176:Complement C3; D003165:Complement System Proteins