title: [Clinical trial of the activity and therapeutic effectiveness of 3 drugs with diuretic and antihypertensive action].
abstract: The Authors have examined, by statistical analysis of the variance for a three-period cross-over design, the effects of fenquizone, furosemide and chlorthalidone on 24 in-patients affected by hypertension, edematous cardiac, renal and liver diseases. The fenquizone, given at doses of 20 mg/die/os, has shown an hypertensive activity comparable to that of the other two diuretic compounds. Such an activity occurs without secondary effects on the heart rate, the electrolites and acid-base balance and on the other parameters taken into account among which the renal functionality test, uricemia and glycemia. At low doses fenquizone has an hypotensive action without showing the characteristics secondary effects of diuretics so that it can be employed for long-term treatments without any risk.
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001769:Blood / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002752:Chlorthalidone / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004232:Diuretics / Q000627:therapeutic use*; D005260:Female; D005665:Furosemide / Q000627:therapeutic use*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011799:Quinazolines / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; D011799:Quinazolines; D005665:Furosemide; C007712:fenquizone; D002752:Chlorthalidone
vernacular_title: Sperimentazione clinica dell'attività e dell'efficacia terapeutica di tre farmaci ad azione diuretica ed antiipertensiva.