Lipid synthesis from the liver in patients with psoriasis.
In psoriatic patients with hyperlipidemia we studied the hepatic lipid synthesis from (1-(14)C)-acetate in human liver biopsy specimens in vitro by a thin-layer radio-chromatography. In psoriatics type IV (according to Fredrickson) a significant increase in (1-(14)C)-acetate hepatic incorporation especially into phospholipids (25%) and triglycerides (52%) was observed; in type IIb increased lipogenesis was phospholipids (24.5%), free cholesterol (44.4%) and triglycerides (29%). Abnormal lipid metabolism often coexists with glucose intolerance in psoriasis; no correlation between hyperinsulinemia and augmented (1-(14)C)-acetate incorporation into hepatic triglycerides was found.
D000328:Adult; D006801:Humans; D006949:Hyperlipidemias / Q000378:metabolism; D007328:Insulin / Q000502:physiology; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism*; D008875:Middle Aged; D011565:Psoriasis / Q000378:metabolism*
D007328:Insulin; D008055:Lipids