Comparison of fenoterol and terbutaline administered by intermittent positive pressure breathing.
The bronchodilator properties and side-effects of three doses of fenoterol (0.5 mg, 1 mg and 2 mg) and terbutaline (2.5 mg, 5 mg and 10 mg) were assessed in 12 patients with stable chronic asthma. The drugs were administered by intermittent positive pressure breathing (IPPB) in 40% oxygen via a Bennett ventilator. No differences likely to be of clinical significance were found between the effects of the three different dose levels of fenoterol and terbutaline, although terbutaline had a significantly greater duration of action. It is concluded that fenoterol 2 mg and terbutaline 10 mg can be administered by IPPB in 40% oxygen for the treatment of asthma.
D000368:Aged; D001249:Asthma / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004983:Ethanolamines / Q000008:administration & dosage*; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage* / Q000627:therapeutic use; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration; D012123:Pulmonary Ventilation; D013726:Terbutaline / Q000008:administration & dosage* / Q000627:therapeutic use; D013997:Time Factors; D014797:Vital Capacity
D004983:Ethanolamines; D005280:Fenoterol; D013726:Terbutaline