title: Structure-activity relationship within a series of m-diaminobenzene derivatives.
abstract: We investigated the mutagenicity of m-diaminobenzene (m-phenylenediamine) and four 2,4-diaminoalkylbenzenes (methyl, ethyl, isopropyl and n-butyl) in Salmonella typhimurium strains TA100, TA1538 and TA98 in the absence and presence of S9 induced by Acoclor 1254. m-Diaminobenzene was the most active mutagen, followed by 2,4-diaminotoluene and 2,4-diaminoethylbenzene, resp. Negative response was observed for both 2,4-diaminoisopropylbenzene and 2,4-diamino-n-butylbenzene. Thus, depending on the size of the substituting alkyl group at the C1 position of 2,4-diaminoalkylbenzene, a decline and loss of mutagenic activity was observed.
mesh_terms: D001555:Benzene Derivatives / Q000494:pharmacology*; D003959:Diamines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005821:Genetic Techniques; D009153:Mutagens; D010655:Phenylenediamines / Q000494:pharmacology; D012486:Salmonella typhimurium / Q000235:genetics; D013329:Structure-Activity Relationship
chemical_list: D001555:Benzene Derivatives; D003959:Diamines; D009153:Mutagens; D010655:Phenylenediamines