Gastrointestinal toxicity of minor analgesics.
1 The evidence for the risk of gastric erosions from aspirin is fragmentary. 2 Occult gastric bleeding following aspirin is poorly studied and the skewed distribution is unexplained; platelet factors may be relevant. 3 Overt gastric bleeding may follow aspirin; the risk is probably about one episode per two million doses. 4 There is epidemiological, clinical, experimental and histopathological evidence for an association between chronic aspirin use and chronic gastric ulcer. 5 An alternative to the Davenport hypothesis is proposed to explain the gastric action of aspirin and the non-steroidal anti-inflammatory agents. 6 Paracetamol is probably bland in its gastric actions.
D000700:Analgesics / Q000009:adverse effects*; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D001241:Aspirin / Q000009:adverse effects; D001792:Blood Platelets / Q000502:physiology; D002110:Caffeine / Q000009:adverse effects; D004338:Drug Combinations; D005767:Gastrointestinal Diseases / Q000139:chemically induced*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D006801:Humans; D013276:Stomach Ulcer / Q000139:chemically induced
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D002110:Caffeine; D001241:Aspirin