Treatment of brain giomas with high dose of CCNU and autologous bone marrow transplantation.
Seven patients with recurrent brain gliomas were treated by a single dose of CCNU 390 mg per m2. In five cases, chemotherapy was followed by autologous bone marrow transfusion containing 1.5 to 3 X 10(8) nucleated cells, 2.8 to 18 X 10(4) clusters plus colonies and 0.4 to 5 X 10(4) colonies forming cells per kg of body weight. Two patients were not grafted. None of these patients showed a clear cut response to the treatment as judged by clinical improvement and changes of the brain CT-scan. In 3 patients blood toxicity occurred early and was severe. In 4 others, it was milder and delayed. The duration and the severity of blood toxicity were modified by bone marrow transfusion but only slightly.
D016026:Bone Marrow Transplantation; D001932:Brain Neoplasms / Q000628:therapy*; D005910:Glioma / Q000628:therapy*; D006402:Hematologic Diseases / Q000139:chemically induced; D006801:Humans; D008130:Lomustine / Q000009:adverse effects / Q000627:therapeutic use*; D009607:Nitrosourea Compounds / Q000627:therapeutic use*; D012008:Recurrence; D014182:Transplantation, Autologous
D009607:Nitrosourea Compounds; D008130:Lomustine