Prostacyclin and blood glucose levels in humans and rabbits.
In patients with peripheral vascular disease and in healthy rabbits, infusion of PGI2 but not of 6-keto PGF1 alpha induced a rise in blood glucose level and a pathological deviation in glucose tolerance test. In experiments in vitro, the increased concentrations of glucose produced dose-dependent inhibition of PGI2 release from isolated rat aortic rings. The link between PGI2 and carbohydrate metabolism is discussed.
D015121:6-Ketoprostaglandin F1 alpha; D000328:Adult; D000368:Aged; D000818:Animals; D001011:Aorta / Q000378:metabolism; D001157:Arterial Occlusive Diseases / Q000097:blood*; D001162:Arteriosclerosis Obliterans / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D011464:Epoprostenol / Q000378:metabolism / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D005951:Glucose Tolerance Test; D006801:Humans; D008875:Middle Aged; D011453:Prostaglandins / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013919:Thromboangiitis Obliterans / Q000097:blood
D001786:Blood Glucose; D011453:Prostaglandins; D011460:Prostaglandins F; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol; D005947:Glucose