title: Plasma glutamate dehydrogenase: clinical application in patients with alcoholic liver disease.
abstract: The time course of plasma glutamate dehydrogenase (GDH) elevation was studied in 42 male alcoholics admitted for alcohol detoxification or for the treatment of medical complications of alcoholism and in 2 volunteers consuming 2 g/kg/day of ethanol under metabolic ward conditions. GDH values were usually highest during or immediately after cessation of drinking; thereafter, they fell rapidly toward the normal range. Early GDH values correlated well with liver histology in 37 patients who subsequently underwent diagnostic liver biopsy.
mesh_terms: D004798:Enzymes / Q000097:blood; D005260:Female; D005969:Glutamate Dehydrogenase / Q000097:blood*; D006801:Humans; D008099:Liver / Q000473:pathology; D008108:Liver Diseases, Alcoholic / Q000201:enzymology* / Q000473:pathology; D008297:Male; D013997:Time Factors
chemical_list: D004798:Enzymes; D005969:Glutamate Dehydrogenase