[Effect of the inhibitor-antioxidant belonging to the 3-hydroxypyridine series on immunocompetent and stem cells].
The effect of the synthetic inhibitor-antioxidant belonging to the 3-hydroxypyridine series (compound OP-6) on the functions of immunocompetent and stem cells of mice was studied. Use was made of the models of synthesis of antibodies to sheep red blood cells (local hemolysis and hemagglutination), of endogeneic and exogeneic colony-formation in (CBA X C57BL)F1 mice as well as skin homotransplantation to CBA mice from C57BL/6 donors. Compound OP-6 was shown to exert an immunodepressant effect on both the humoral and cell immunity, not to decrease the colony-forming capacity of the stem cells and to protect them from irradiation.
D000818:Animals; D000917:Antibody Formation; D000975:Antioxidants; D006384:Hemagglutination; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000276:immunology*; D006461:Hemolysis; D007111:Immunity, Cellular; D007121:Immunocompetence / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D011725:Pyridines / Q000494:pharmacology*; D016038:Skin Transplantation; D013045:Species Specificity; D014184:Transplantation, Homologous
D000975:Antioxidants; D011725:Pyridines; C023500:3-hydroxypyridine
Vllianie ingibitora-antioksidanta iz klassa 3-oksipiridina na immunokompetentnye i stvolovye kletki.