title: The effect of cooling rate during perfusion on function and morphology of rabbit kidney grafts.
abstract: The effect of cooling of rabbit kidneys during the initial flush with Collins' solution for simple hypothermic storage was studied. After cooling at an average rate of 3.7 degrees C/min. graft function was found to be immediately life-sustaining, and renal morphology after perfusion as well as 30 min. and 24 hours posttransplant was found to be normal. Posttransplant function after cooling at a rate of 7.2 degrees C/min. was significantly lower, permitting survival of only 30% of recipient animals, and damage was seen in proximal tubular cells.
mesh_terms: D000818:Animals; D003080:Cold Temperature; D006084:Graft Rejection; D007668:Kidney / Q000033:anatomy & histology* / Q000502:physiology*; D016030:Kidney Transplantation; D009926:Organ Preservation; D010477:Perfusion; D011817:Rabbits; D013997:Time Factors