[Test of pituitary adrenal suppressibility with I.V. dexamethsaone in the diagnosis of Cushing's syndrome (author's transl)].
The authors report a pituitary adrenal suppressibility test, using a 4 h IV infusion of dexamethasone phosphate (4 mg). Plasma cortisol is measured before and at the end of the infusion. The results allow a good discrimination between Cushing's disease (bilateral adrenal hyperplasia: 9 cases) and Cushing's syndrome of tumorous origin (adrenal tumors 7 cases, ectopic ACTH syndrome 3 cases, hypophyseal adenomas 2 cases), only bilateral adrenal hyperplasia cases are lowering significantly.
D000302:Adrenal Cortex / Q000187:drug effects; D003480:Cushing Syndrome / Q000175:diagnosis*; D003864:Depression, Chemical; D003907:Dexamethasone / Q000008:administration & dosage; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007263:Infusions, Parenteral
D003907:Dexamethasone; D006854:Hydrocortisone
Le test de freinage cortico-surrénal par le phosphate de dexaméthasone intra-veineux.