Genetic regulation of alcohol dehydrogenase, aldehyde dehydrogenase and aldehyde oxidase isozymes in the mouse.
Electrophoretic and activity variants for the C2 isozyme of alcohol dehydrogenase (ADH-C2), the mitochondrial isozyme of aldehyde dehydrogenase (AHD-A2) and aldehyde oxidase isozymes (AOX-1; AOX-2) in inbred strains of Mus musculus were used to map the genes encoding these enzymes on the mouse genome. Adh-3 (encoding ADH-C2) was localized on chromosome 3 and was closely linked to a cis-acting regulator locus (Adh-3-t), which determined ADH-C2 activity in male reproductive tissues. Ahd-1 (encoding AHD-A2) was found on chromosome 4 near Gpd-1 (encoding the liver isozyme of glucose-6-phosphate dehydrogenase), whereas the aldehyde oxidase loci (Aox-1, Aox-2) were closely linked on chromosomes 1 near Id-1 (encoding isocitrate dehydrogenase).
D000429:Alcohol Oxidoreductases / Q000235:genetics*; D000445:Aldehyde Oxidoreductases / Q000235:genetics*; D000818:Animals; D002875:Chromosomes; D066298:In Vitro Techniques; D007527:Isoenzymes / Q000235:genetics*; D008099:Liver / Q000201:enzymology; D051379:Mice; D008815:Mice, Inbred Strains
D007527:Isoenzymes; D000429:Alcohol Oxidoreductases; D000445:Aldehyde Oxidoreductases