[Toxicity and dose-response (effect) relationship of n-hexane (author's transl)].
A large amount of n-hexane is being widely used in industry as a solvent or a component of the mixed solvents for extraction of vegetable oils, adhesives, paints, and for cleaning, etc. And, many cases of polyneuropathy due to n-hexane have been reported up to now. Recently, studies on the neurotoxicity and metabolism of n-hexane rapidly progressed in many countries. The present review covers clinical signs and symptoms, pathological changes, metabolism, dose-response (effect) in acute exposure, glue or thinner sniffers, workers, animal experiments. The joint effects and the maximal allowable concentration of n-hexane are also briefly discussed.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006586:Hexanes / Q000378:metabolism / Q000506:poisoning / Q000633:toxicity*; D006801:Humans; D008297:Male; D008452:Maximum Allowable Concentration; D051379:Mice; D009420:Nervous System / Q000473:pathology; D009784:Occupational Diseases / Q000139:chemically induced; D011115:Polyneuropathies / Q000139:chemically induced; D051381:Rats; D019966:Substance-Related Disorders / Q000209:etiology
D006586:Hexanes; C026385:n-hexane