[Synthesis of xyloidone and lapachone analogs].
Several xiloidone analogues were prepared, in a one step reaction, by the alkylation of lawsone with aldehydes obtained from natural essential oil sources. By Pd/C hydrogenation of these xyloidone derivatives, alpha-lapachone analogues were obtained in high yield. beta-lapachone isomers were prepared from the alpha-derivatives by treatment with sulphuric acid.
D000478:Alkylation; D055598:Chemical Phenomena; D002621:Chemistry; D006865:Hydrogenation; D066298:In Vitro Techniques; D007536:Isomerism; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects
D009285:Naphthoquinones; C029244:xyloidone; C014638:beta-lapachone
Síntese de análogos de xiloidonas e lapachonas.