Glucose uptake and insulin secretory responses to intravenous glucose loads in the dog.
Twenty-one healthy young non-anesthetized Dalmatian dogs (10 male, 11 female) were given IV glucose loads between 300 and 1,500 mg/kg of body weight in a standard time period of 30 s. The fractional glucose turnover rates and the insulin peak responses gradually increased with glucose loads to 1,000 mg/kg and the total insulin secretion with loads to 1,250 mg/kg and remained constant. The insulinogenic index (delta I/delta G) varied inversely with the size of the glucose loads. The pattern of responses indicates that the optimum glucose load is near 600 mg/kg for evaluating normal glucose metabolism in dogs by the IV glucose loading technique.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D004285:Dogs / Q000097:blood*; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test / Q000662:veterinary*; D007328:Insulin / Q000097:blood*; D008297:Male; D012737:Sex Factors
D001786:Blood Glucose; D007328:Insulin