title: Congenital hypothyroidism. Clinicopathological aspects and biochemical screening.
abstract: Congenital hypothyroidism is the commonest endocrine disorder of childhood. Early thyroxine therapy will ameliorate or prevent the considerable physical and mental retardation that is the hallmark of infantile hypothyroidism, and evidence is presented that a neonatal screening programme for thyroid hormones will reveal evidence of primary thyroid hypofunction (1/4 500 births) in infants prior to clinical diagnosis.
mesh_terms: D000014:Abnormalities, Drug-Induced; D002675:Child, Preschool; D003409:Congenital Hypothyroidism; D005260:Female; D005333:Fetus / Q000378:metabolism; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis / Q000628:therapy; D007223:Infant; D007231:Infant, Newborn; D011247:Pregnancy; D013019:South Africa; D013961:Thyroid Gland / Q000002:abnormalities / Q000378:metabolism / Q000502:physiology; D013963:Thyroid Hormones / Q000172:deficiency / Q000378:metabolism; D013997:Time Factors
chemical_list: D013963:Thyroid Hormones