title: [Morphological and biochemical characteristics of Streptomyces hygroscopicus mutants obtained under the action of acridine orange and mitomycin C].
abstract: The purpose of this work was to study the action of acridine orange and mitomycin C on the production of mutants of Streptomyces hygroscopicus, strain 0681. The mutagen activity of mitomycin C was shown to be high. The vegetative culture grown for 24 hours produced more mutants under the action of mitomycin C than spores did. Both acridine orange and mitomycin C caused the production of mutants in strain 0681. The morphology of colonies in these mutants was modified, the synthesis of hygromycin B was completely or partly blocked, and the composition of fatty acids changed quantitatively and qualitatively. Mutants induced by mitomycin C were highly active in the production of the complex of hygrolytin proteolytic enzymes.
mesh_terms: D000165:Acridine Orange / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D006921:Hygromycin B / Q000096:biosynthesis; D008937:Mitomycins / Q000494:pharmacology*; D009154:Mutation; D010447:Peptide Hydrolases / Q000096:biosynthesis; D013171:Spores, Bacterial / Q000187:drug effects; D013302:Streptomyces / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
chemical_list: D008937:Mitomycins; D006921:Hygromycin B; D010447:Peptide Hydrolases; C021429:hygrolytin; D000165:Acridine Orange
vernacular_title: Morfologo-biokhimicheskaia kharakteristika mutantov Streptomyces hygroscopicus, poluchennykh pod deistviem akridina oranzhevogo i mitomitsina C.