Effect of trypsin inhibitor on the degradation and transfer of immunoglobulin across the small intestine of the suckling rat.
The effects of certain chemical additives on, and the molecular characteristics of, the intestinal proteases of the suckling rat have been investigated. The catheptic activity of the intestinal wall was thiol dependent, whereas the luminal protease was markedly inhibited by trypsin inhibitor. There was no significant improvement in immunoglobulin transport across the gut wall on inhibition of luminal proteolytic activity.
D000818:Animals; D001692:Biological Transport; D003545:Cysteine / Q000494:pharmacology; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D007421:Intestine, Small / Q000187:drug effects / Q000201:enzymology / Q000276:immunology*; D007461:Iodoacetates / Q000494:pharmacology; D010447:Peptide Hydrolases / Q000378:metabolism; D051381:Rats; D014358:Trypsin Inhibitor, Bowman-Birk Soybean / Q000494:pharmacology*; D014361:Trypsin Inhibitors / Q000494:pharmacology*
D007074:Immunoglobulin G; D007461:Iodoacetates; D014358:Trypsin Inhibitor, Bowman-Birk Soybean; D014361:Trypsin Inhibitors; D010447:Peptide Hydrolases; D003545:Cysteine