Correspondent reaction of mitotic recombination in yeast and sister chromatid exchange in human lymphocytes.
In the lower eukaryote Saccharomyces cerevisiae, 4,5,6-trichloro-2-(dichlorophenoxy)phenol and acridine orange cause different specific genetic alterations, either gene mutations or recombinations. These specific effects were used to characterize the mechanism of sister chromatid exchange (SCE) formation in human lymphocytes. Assuming that genetically active substances have comparable effects in lower and higher eukaryotes, the observations provide indirect evidence for a connection between induced mitotic recombination in yeast and SCEs in human lymphocytes and suggest that SCEs may be the consequence of a repair process.
D000165:Acridine Orange / Q000494:pharmacology; D003434:Crossing Over, Genetic / Q000187:drug effects*; D004260:DNA Repair; D055768:Halogenated Diphenyl Ethers; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D010647:Phenyl Ethers / Q000494:pharmacology; D011995:Recombination, Genetic / Q000187:drug effects*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D014265:Triethylenemelamine
D055768:Halogenated Diphenyl Ethers; D010647:Phenyl Ethers; C012480:predioxin; D000165:Acridine Orange; D014265:Triethylenemelamine