Distribution of cytoskeletal elements in cultured skin fibroblasts of patients with Duchenne's muscular dystrophy.
Cultured fibroblasts from patients suffering from Duchenne's Muscular Dystrophy were examined by indirect immunofluorescent techniques using antibodies against actin, myosin, tubulin, and intermediate-sized filaments. The cells display normal patterns of microfilamentous bundles (stress fibres), microtubules, and intermediate-sized filaments suggesting a normal organization of these cytoskeletal structures.
D000199:Actins / Q000032:analysis; D005347:Fibroblasts / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006801:Humans; D009124:Muscle Proteins / Q000032:analysis*; D009136:Muscular Dystrophies / Q000378:metabolism*; D009218:Myosins / Q000032:analysis; D012867:Skin / Q000032:analysis*; D014404:Tubulin / Q000032:analysis*
D000199:Actins; D009124:Muscle Proteins; D014404:Tubulin; D009218:Myosins