[Disturbances of the calcium-phosphorus metabolism and skeletal diseases following kidney transplantation].
53 patients were followed up for an average of 3 years after renal transplantation for evaluation of disturbances in calcium-phosphorus metabolism and skeletal diseases. Postoperative hypercalcemia and hypophosphatemia can be related to persistence of hyperparathyroidism when kidney function is restored. Hypercalcemia was observed in 43% of the patients and lasted less than one year in 80% of cases. Transient hypophosphatemia was present in 15%. These abnormalities did not cause clinical symptoms or deterioration of renal function. However, the skeletal diseases are more impressive and in the first place osteopenia. Bone densitometry revealed decreased bone mineral content in two thirds of the females and one fifth of the males. In females the bone density decreased 3.3% during an average observation period of 7 months, but remained constant in males. Renal osteodystrophy is the main cause of the initial osteopenia. The absence of remineralization or the progression of bone losses is related to the initial persistence of hyperparathyroidism and to corticosteroid treatment. According, 12.5% of the patients presented pathological fractures (spine, hip). In 3 patients (5.7%) with reduced transplant function, osteomalacia without hypophosphatemia was observed. 4 patients (7.5%) had osteonecrosis of the femoral head. There was little progression and surgery was not necessary.
D000328:Adult; D002118:Calcium / Q000097:blood*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000097:blood*; D005260:Female; D005271:Femur Head Necrosis / Q000097:blood; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000097:blood; D016030:Kidney Transplantation; D008297:Male; D010018:Osteomalacia / Q000097:blood; D010020:Osteonecrosis / Q000097:blood; D010024:Osteoporosis / Q000097:blood; D010758:Phosphorus / Q000097:blood*; D011183:Postoperative Complications / Q000097:blood*; D011884:Radius / Q000378:metabolism; D013977:Tibia / Q000378:metabolism; D014184:Transplantation, Homologous
D010758:Phosphorus; D002118:Calcium
Störungen des Calcium-Phosphor-Stoffwechsels und Erkrankungen des Skeletts nach Nierentransplantation.