Efficacy of captopril in experimental low renin hypertension.
Captopril (SQ 14225) had a clear antihypertensive effect in rat Heymann nephritis-DOCA-NaCl hypertension, a low renin model introduced recently, but was ineffective in 1-kidney-DOCA-NaCl hypertension although plasma renin activity (PRA) was suppressed similarly in both. Thus, the antihypertensive effect of captopril was independent of circulating renin. This result also suggests different pathogenetic mechanisms of hypertension in these two DOCA-NaCl models.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006973:Hypertension / Q000188:drug therapy*; D007610:Kallikreins / Q000378:metabolism; D011392:Proline / Q000031:analogs & derivatives*; D051381:Rats; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000378:metabolism
D011392:Proline; D002216:Captopril; D012964:Sodium; D007610:Kallikreins; D012083:Renin