[Oral administration effects, with different doses, of arginine aspartate and arginine chlorhydrate upon growth hormone and free fatty acids plasmatic rates in normal fasting children (author's transl)].
With an equivalent arginine base furniture, arginine chlorhydrate (CA) and arginine aspartate (AA) are orally administered, with variable doses, to normal fasting children, to study during 4 hours evolution of plasmatic growth hormone rates (stimulation of endogenous GH secretion) and plasmatic free fatty acids rates (secondary effects on effectors). With CA 5 g (half dose) opr 10 g (total dose, about 500 mg/kg) mean plasmatic GH rates increase is etale and non significant, when compared to normals. With AA 7,35 g (half dose) or 14,70 g (total dose), there is a 2 h GH peak, when compared to initial values and 2 h normal values (p less than 0,05 or p less than 0.01). Area increases with the two doses AA, when compared to normals (p less than 0,01). With the two products, mean 1 h plasmatic FFA rate does not vary or non significantly decreases. 4 h rate increases, when compared to normals, with CA and AA half dose (p less than 0,05) and CA and AA total dose (p less than 0,01).
D000284:Administration, Oral; D001120:Arginine / Q000008:administration & dosage / Q000494:pharmacology*; D001224:Aspartic Acid / Q000494:pharmacology*; D002648:Child; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D008297:Male; D013997:Time Factors
D005230:Fatty Acids, Nonesterified; D001224:Aspartic Acid; D013006:Growth Hormone; D001120:Arginine; C024891:arginine aspartate
Effets de l'administration "Per Os", à doses variables, d'aspartate d'arginine et de chlorhydrate d'arginine sur les taux d'hormone de croissance et d'acides gras libres du plasma chez l'enfant normal à jeun.