A study of surface markers in gastrointestinal lymphoma.
Five cases of gastrointestinal lymphomas were studied in relation to their surface antigenic markers by using specific antisera against human B cells or T cells. Frozen sections of the tumor tissues stained by immunofluorescence with these antisera were utilized for the detection of surface antigens on the lymphoma cells. The lymphomas reported included two nodular and three diffuse lymphocytic tumors. Their cellular morphology varied, ranging from well-differentiated to undifferentiated. Despite such a variability, all cases showed positive fluorescence with antihuman B-lymphocyte serum while being negative with antihuman T-lymphocyte serum. Four cases were further tested for their surface immunoglobulin classes, and it was found that all of the cases possessed IgM on their cell surface. They carried only one type of light-chain class, either kappa (3 cases) or lambda (1 case). These data suggest that the gastrointestional lymphomas presented here are derived from monoclonal proliferation of malignant B lymphocytes in the digestive tract.
D000368:Aged; D000954:Antigens, Surface / Q000145:classification*; D002675:Child, Preschool; D005260:Female; D005455:Fluorescent Antibody Technique; D005770:Gastrointestinal Neoplasms / Q000276:immunology*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology; D008223:Lymphoma / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D000954:Antigens, Surface