T lymphocytes expressing human Ia-like antigens in infectious mononucleosis (IM).
In six patients with Epstein-Barr virus (EBV) induced infectious mononucleosis (IM) and in two patients with IM-like syndrome, peripheral blood lymphocytes in the acute and convalescent phase were tested for human la-like antigens as well as other cell surface markers. The major population of T lymphocytes in the acute phase showed la-like antigens, as detected by indirect immunofluorescence with heteroantisera, and the number of la-like antigen-positive T lymphocytes decreased with convalescence. The crossabsorption study indicated that the amount of la-like antigen on the surface of IM T cells was less than that of Raji cells.
D000328:Adult; D000954:Antigens, Surface; D005260:Female; D005455:Fluorescent Antibody Technique; D000949:Histocompatibility Antigens Class II; D006801:Humans; D007163:Immunosorbent Techniques; D007244:Infectious Mononucleosis / Q000276:immunology*; D007519:Isoantigens; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*
D000954:Antigens, Surface; D000949:Histocompatibility Antigens Class II; D007519:Isoantigens