Poisoning with N-3-pyridylmethyl-N'-p-nitrophenylurea (Vacor). Immunoperoxidase demonstration of beta-cell destruction.
A 49-year-old woman ate N-3-pyridylmethyl-N'-p'nitrophenylurea (PNU; Vacor) and was admitted to the hospital 12 hours later with a blood glucose level of 940 mg/dl and an anion-gap metabolic acidosis. Her diabetes was successfully treated, but she contained to manifest severe orthostatic hypotension. A painless ileus developed, followed by cecal perforation and death. Immunoperoxidase staining of paraffin-embedded pancreatic tissue obtained during postmortem examination clearly demonstrated the pancreatic beta-cell destruction. Results of this same staining technique also suggested that fewer alpha cells were present.
D001921:Brain / Q000473:pathology; D002470:Cell Survival; D003106:Colon / Q000473:pathology; D005260:Female; D006801:Humans; D007082:Ileum / Q000473:pathology; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology*; D010537:Peritoneum / Q000473:pathology; D010671:Phenylurea Compounds / Q000506:poisoning*
D010671:Phenylurea Compounds; C012598:pyriminil