title: The role of membrane fatty acids in mammalian hibernation.
abstract: During mammalian hibernation, cellular membranes continue to function at temperatures approaching 0 C. The molecular mechanisms that confer this capacity to the membranes are unknown but may be related to the fluidity of the membrane and to the level of unsaturated fatty acids. The basic tenets of membrane fluidity and the contribution of cholesterol, polar head groups, and fatty acids toward maintaining a fluid membrane in a liquid-crystalline state are examined in this review. It is shown that although unsaturated fatty acids can enhance membrane fluidity at low temperatures, there does not appear to be a consistent trend toward increased levels of unsatruated fatty acids during hibernation in all tissues of hibernators. Consequently, there may be some other role for the alterations in the composition of membrane fatty acids found during the hibernating cycle other than increasing membrane fluidity to permit continued activity at reduced temperatures.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D006224:Cricetinae; D005227:Fatty Acids / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D006605:Hibernation; D008099:Liver / Q000378:metabolism; D008322:Mammals / Q000502:physiology*; D008563:Membrane Lipids / Q000378:metabolism*; D008647:Mesocricetus; D009206:Myocardium / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D012589:Sciuridae
chemical_list: D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D008563:Membrane Lipids; D010743:Phospholipids