[Esterification of cholesterol in patients with renal transplants. Determination of lecithin:cholesterol-acyl-transferase (LCAT) activity].
In man, cholesterol esterification is controlled by lecithin:cholesterol-acyl-transferase (LCAT), which is a key-role enzyme of lipid metabolism. Though LCAT is synthesized by the hepatocytes, its activity seems to be linked to the kidney: in fact, LCAT activity is lowered in uremic and anephric subjects, and probably also in long-term haemodialysis patients. On the contrary, in successfull renal allografts we found fully restored LCAT activity. But physiopathological mechanisms underlying relationships between LCAT and kidney are still unclarified.
D002784:Cholesterol / Q000378:metabolism*; D004951:Esterification; D006801:Humans; D016030:Kidney Transplantation; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood*; D014184:Transplantation, Homologous
D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase
Esterificazione del colesterolo in portatori di trapianto renale. Determinazione dell'attività lecitin: colesterol-acil-transferasica (LCAT).