Hypothesis: the pathogenesis of pseudotumor cerebri.
In susceptible individuals, one of a variety of known or unknown precipitants affects the arachnoid villi so as to produce a large increase in CSF outflow resistance, Ra. This increase in Ra raises CSF pressure (CSFP), which rise provokes a redistribution of arteriovenous pressures across the cerebrovascular bed. The end result is a measurable increase in cerebral blood volume, compression of the ventricular system and compromise of the convexity subarachnoid space, which further increases CSF outflow resistance. Ultimately, a new steady state CSFP is attained.
D001929:Brain Edema / Q000150:complications; D002908:Chronic Disease; D006801:Humans; D006849:Hydrocephalus / Q000150:complications; D008954:Models, Biological; D011559:Pseudotumor Cerebri / Q000134:cerebrospinal fluid / Q000150:complications / Q000209:etiology*