title: Correction of enzyme deficiency in mice by allogeneic bone marrow transplantation with total lymphoid irradiation.
abstract: Enzyme deficiency was corrected in mice after allogeneic bone marrow transplantation with occurrence of graft versus host disease. beta-Glucuronidase-deficient C3H/HeJ mice were treated with total lymphoid irradiation. Normal bone marrow cells (30 X 10(6)) from BALB/c to C3H/HeJ chimeras (>90 percent circulating donor-type cells) without graft versus host disease. beta-Glucuronidase activity increases to normal levels in all chimeras as measured in the liver and in the plasma. Activity was maintained throughout an observation period of 7 months.
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation; D005966:Glucuronidase / Q000097:blood / Q000172:deficiency*; D008099:Liver / Q000201:enzymology; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D011828:Radiation Chimera; D014184:Transplantation, Homologous
chemical_list: D005966:Glucuronidase