Prostaglandin and thromboxane production by the rat uterus and ovary in vitro during the oestrous cycle.
The major prostaglandin (PG) synthesized by homogenates of the rat uterus and ovary in vitro was prostacyclin (PGI-2), has reflected by the amounts of 6-oxo-PGF-1 alpha produced. Thromboxane production by both tissues was low, whereas appreciable quantities of PGF-2 alpha, PGE-2 and PGD-2 were produced. Prostaglandin production by the uterus was higher on Day 1 (oestrus) than on Day 3 (dioestrus), although the ratio of the amounts of the PGs formed remained fairly constant for each day. There was no daily variation in the amounts of PGs synthesized by the ovary. Metabolism of PGF-2 alpha by the rat uterus and ovaries was generally low, although the ovaries had a higher metabolizing capacity than the uterus. Metabolism by the uterus was higher on Day 1 than on Day 3 of the cycle. The decreased production of PG  by the uterus on Day 3 is therefore not due to increased metabolism.
D000818:Animals; D011464:Epoprostenol / Q000096:biosynthesis; D004971:Estrus; D005260:Female; D066298:In Vitro Techniques; D010053:Ovary / Q000378:metabolism*; D011247:Pregnancy; D011453:Prostaglandins / Q000096:biosynthesis*; D011457:Prostaglandins D / Q000096:biosynthesis; D011458:Prostaglandins E / Q000096:biosynthesis; D011460:Prostaglandins F / Q000096:biosynthesis / Q000378:metabolism; D051381:Rats; D013929:Thromboxane B2 / Q000096:biosynthesis*; D013931:Thromboxanes / Q000096:biosynthesis*; D014599:Uterus / Q000378:metabolism*
D011453:Prostaglandins; D011457:Prostaglandins D; D011458:Prostaglandins E; D011460:Prostaglandins F; D013931:Thromboxanes; D013929:Thromboxane B2; D011464:Epoprostenol