title: [Cerebral computed tomography in acute childhood leukemias].
abstract: It is suggested that cranial computerized (axial) tomography permits a more complete neurologic work-up for all children with acute leukemia. It also permits a better knowledge of the frequency and varieties of cerebral complications in leukemia. Endocranial complications in acute leukemia are essentially infiltrative, hemorrhagic, infectious or iatrogenic. Cranial computerized tomography can demonstrate cerebral changes in meningeal leukemia, hemorrhages, calcifications, brain atrophy or leukencephalopathy. The preliminary results of cranial computerized tomography in childhood leukemia suggest that the iatrogenic main lesion of the brain due to combined radiation-chemotherapy is atrophy whereas that of the intrathecal cytostatic therapy is demyelination. Accurate diagnostics and control of possible cerebral complications in therapy of leukemia is essentially for appropriate therapeutic management. For that cranial computerized tomography may be the best method to a effective exploration of the brain.
mesh_terms: D000208:Acute Disease; D000970:Antineoplastic Agents / Q000009:adverse effects; D001284:Atrophy; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis*; D002543:Cerebral Hemorrhage / Q000175:diagnosis; D002648:Child; D006801:Humans; D007938:Leukemia / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D008577:Meningeal Neoplasms / Q000175:diagnosis*; D011878:Radiotherapy / Q000009:adverse effects; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Zerebrale Computertomographie bei akuten Leukämien im Kindesalter.