title: [Free, total and antibody-bound insulin content in newly detected diabetes mellitus patients].
abstract: Free, total and antibody-bound insulin blood content was studied before and after intravenous secretin injections in patients with first diagnosed diabetes mellitus and in healthy persons. The content of total and antibody-bound insulin was higher and that of active free insulin comparatively lower in diabetic patients. The secretin test revealed normal beta-cell reserves for the total insulin synthesis and reduced ones for free insulin formation. The treatment with protamine-zinc-insulin provoked spontaneous and stimulated secretion of total and free insulin. The antibody-bound insulin level remained unchanged.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003920:Diabetes Mellitus / Q000097:blood* / Q000188:drug therapy; D005215:Fasting; D005260:Female; D005609:Free Radicals; D006801:Humans; D007328:Insulin / Q000097:blood*; D007330:Insulin Antibodies / Q000032:analysis*; D049528:Insulin, Long-Acting / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012633:Secretin; D013997:Time Factors
chemical_list: D005609:Free Radicals; D007328:Insulin; D007330:Insulin Antibodies; D049528:Insulin, Long-Acting; D012633:Secretin
vernacular_title: Soderzhanie svobodnogo, obshchego i sviazannogo s antitelami insulina u bol'nykh s vpervye vyiavlennym sakharnym diabetom.