A prospective trial of 5-FU and BCNU in the treatment of advanced gastric cancer.
This study was undertaken to investigate the efficacy of a combination of 5-FU and BCNU in the treatment of advanced gastric cancer. Patients whose cancer was recurrent following surgery or in whom surgery was deemed inappropriate were entered in the study and given the two-drug combination at six-weekly intervals until either death or clear progression of disease occurred. Five of twenty-eight patients had unequivocal regression of their disease. The early optimism for this form of therapy in advanced gastric cancer is not supported by this study.
D000328:Adult; D000368:Aged; D002330:Carmustine / Q000008:administration & dosage* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000601:surgery
D005472:Fluorouracil; D002330:Carmustine