Structure of the neuraminidase gene in human influenza virus A/PR/8/34.
The complete structure of the neuraminidase gene in influenza A/PR/8/34 has been determined by cloning into the bacteriophage M13 and sequencing with dideoxynucleotide chain terminators. The gene is 1,413 nucleotides long, codes for a protein of 454 amino acids and has five potential glycosylation sites. We suggest that the neuraminidase, unlike the influenza haemagglutinin, is oriented with its N-terminus buried in the viral membrane.
D000595:Amino Acid Sequence; D001483:Base Sequence; D002462:Cell Membrane / Q000378:metabolism; D003001:Cloning, Molecular; D003090:Coliphages / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics; D005796:Genes; D009980:Influenza A virus / Q000201:enzymology / Q000235:genetics*; D009439:Neuraminidase / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics*
D004279:DNA, Viral; D014764:Viral Proteins; D009439:Neuraminidase