Reversible acute renal insufficiency and hyperkalemia following indomethacin therapy.
We noted five cases of reversible acute deterioration of renal function in patients with very mild to moderate renal insufficiency who received indomethacin for an acute gouty attack. This decrease in renal function was consistent with a primary decrease in renal blood flow. In addition, hyperkalemia developed in the patients, which we attribute to a decrease in renin and aldosterone secretion, a decrease in distal tubular delivery of sodium, and, more importantly, to a decrease in urine flow. This report is intended to alert physicians to the possible complications of indomethacin therapy in patients with mild renal insufficiency.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D000450:Aldosterone / Q000378:metabolism; D003864:Depression, Chemical; D005260:Female; D006073:Gout / Q000188:drug therapy; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced*; D007213:Indomethacin / Q000009:adverse effects*; D007668:Kidney / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D011453:Prostaglandins / Q000096:biosynthesis; D012083:Renin / Q000378:metabolism; D012636:Secretory Rate / Q000187:drug effects
D011453:Prostaglandins; D000450:Aldosterone; D012083:Renin; D007213:Indomethacin