Chemoprophylaxis with tinidazole in major gynaecological surgery.
A double-blind trial involving 200 patients failed to show a statistically significant reduction in postoperative pelvic infection with tinidazole chemoprophylaxis. Preoperative and postoperative cervical or vaginal bacteriological swabs and full blood counts did not contribute to management. Drains to the vaginal vault were not associated with a reduction in this complication. The incidence of postoperative pelvic sepsis was also unrelated to the experience of the surgeon.
D001424:Bacterial Infections / Q000209:etiology / Q000517:prevention & control; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005334:Fever / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007044:Hysterectomy; D009593:Nitroimidazoles / Q000627:therapeutic use*; D010388:Pelvis; D010919:Placebos; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication; D014011:Tinidazole / Q000627:therapeutic use*; D014621:Vagina / Q000601:surgery*
D009593:Nitroimidazoles; D010919:Placebos; D014011:Tinidazole