Auto anti-M antibody following renal transplantation.
A 25-year-old man with rapidly progressive glomerulonephritis developed an autoantibody with anti-M specificity following haemodialysis and renal transplantation. The patient's red cells typed as MN. The antibody was an IgM globulin which displayed marked dosage effect and variable pH dependence. The thermal range of reactivity extended to 37 degrees C. The stimulus for the production of the antibody is uncertain.
D000328:Adult; D000818:Animals; D000918:Antibody Specificity; D001323:Autoantibodies / Q000096:biosynthesis*; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007075:Immunoglobulin M; D016030:Kidney Transplantation; D008951:MNSs Blood-Group System; D008297:Male; D011817:Rabbits; D006435:Renal Dialysis; D013696:Temperature
D001323:Autoantibodies; D007075:Immunoglobulin M; D008951:MNSs Blood-Group System