Evaluation of onset of bronchodilating effect by interruption of the air flow method.
The speed of onset of the bronchodilating effect of ibuterol, a derivative of terbutaline, was measured by the method of air flow interruptions, which enables an almost continuous study of lung resistance before and after the administration of a bronchodilator. In the double-blind comparison between ibuterol and placebo, the onset of action of the new beta 2-agonist has been shown to take place within 30-45 sec. This indicates that ibuterol is a bronchodilator with rapid onset of action.
D000328:Adult; D000336:Aerosols; D000368:Aged; D001980:Bronchi / Q000187:drug effects / Q000503:physiopathology; D002087:Butyrates / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005540:Forced Expiratory Flow Rates; D005541:Forced Expiratory Volume; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D010919:Placebos; D013726:Terbutaline / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000336:Aerosols; D002087:Butyrates; D010919:Placebos; C011287:ibuterol; D013726:Terbutaline