Effect of an oestrogen antagonist on implantation and uterine leucylnaphthylamidase activity in the ovariectomized hamster.
CI-628 citrate, an oestrogen antagonist, instilled into the uterine lumen of ovariectomized, progesterone-treated hamsters on Day 3 of pregnancy completely prevented implantations. Normal implantations occurred in the contralateral uterine horn which was pierced by a needle and in horns into which saline was instilled. There was less activity of lysosomal leucylnaphthylamidase in implantation sites than in inter-implantation sites and in the tissues of the CI-628 citrate-treated horns.
D000818:Animals; D002369:Castration; D006224:Cricetinae; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D007931:Leucyl Aminopeptidase / Q000378:metabolism*; D008647:Mesocricetus; D009594:Nitromifene / Q000494:pharmacology*; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects / Q000201:enzymology*
D011759:Pyrrolidines; D011374:Progesterone; D009594:Nitromifene; D007931:Leucyl Aminopeptidase