Cytostructural localization of a tumor-associated antigen.
Tumor cell membrane glycoproteins may be involved in the induction of tumor immunity or in the escape of tumors from immunologic defense mechanisms. Forty-four benign and malignant breast lesions were examined for the presence of a carbohydrate precursor antigen (T antigen) of the human blood group system MN. T antigen was demonstrated by means of an immunohistochemical technique to detect tissue binding of peanut agglutinin, a plant lectin, with affinity for T antigen. Malignant breast lesions showed a pattern of T antigen expression different from that of benign breast tissues. A possible role for T antigen in the modulation of the immune response to breast carcinoma is suggested.
D000917:Antibody Formation; D000951:Antigens, Neoplasm; D010367:Arachis; D001943:Breast Neoplasms / Q000276:immunology* / Q000648:ultrastructure; D003593:Cytoplasm / Q000276:immunology; D005260:Female; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D037102:Lectins; D008951:MNSs Blood-Group System; D037121:Plant Lectins
D000951:Antigens, Neoplasm; D006023:Glycoproteins; D037102:Lectins; D008951:MNSs Blood-Group System; D037121:Plant Lectins