title: Neural-tube defects in a prehistoric south-western Indian population.
abstract: Concern with the frequency and patterning of the occurrence of midline neural-tube defects among contemporary human populations is widespread. These defects are, however, quite old and occur in unusually high numbers of prehistoric skeletons. A common explanation offered for such high incidence has been inbreeding among small, reproductively isolated populations. In a sample of 54 skeletons from the prehistoric south-western Indian site of Tijeras Pueblo in New Mexico, failure of neural-tube closure occurs in 10% of sacra recovered. While a more homogeneous genetic background and inbreeding may account for a portion of this elevated prevalence, the cause appears to lie with cultural-environmental factors. It is suggested that the aetiology of these conditions has become more complex in recent human history.
mesh_terms: D000293:Adolescent; D000328:Adult; D002675:Child, Preschool; D003241:Consanguinity; D003466:Cultural Characteristics; D004777:Environment; D005260:Female; D049690:History, Ancient; D006801:Humans; D007198:Indians, North American; D008297:Male; D008875:Middle Aged; D009436:Neural Tube Defects / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D009516:New Mexico; D010164:Paleopathology