Relative potencies of four reference endotoxin standards as measured by the Limulus amoebocyte lysate and USP rabbit pyrogen tests.
Four commonly used reference endotoxin standards, Escherichia coli O113:H10:K0, E. coli O55:B5, Salmonella abortusequi, and Shigella dysenteriae were compared by the USP rabbit pyrogen and the Limulus amoebocyte lysate tests. By the rabbit pyrogen test, S. abortus equi was identified as the most potent endotoxin, followed closely by E. coli O113:H10:K0 and E. coli O55:B5.
D000818:Animals; D001681:Biological Assay; D004731:Endotoxins / Q000633:toxicity*; D004926:Escherichia coli; D005069:Evaluation Studies as Topic; D005334:Fever / Q000139:chemically induced; D008033:Limulus Test; D011817:Rabbits; D012015:Reference Standards; D012475:Salmonella; D012762:Shigella dysenteriae
D004731:Endotoxins