Effect of fever on blood copper level in adrenalectomized animals.
In the experiments on adrenalectomized animals it was shown that the fever-associated rise in the blood copper level was absent in these animals. Hydrocortisone administration to adrenalectomized animals restored the normal reactivity of the animals to injections of pyrogens.
D000315:Adrenalectomy; D000818:Animals; D003300:Copper / Q000097:blood*; D003900:Desoxycorticosterone / Q000494:pharmacology; D004357:Drug Synergism; D004926:Escherichia coli; D005334:Fever / Q000097:blood* / Q000139:chemically induced; D006728:Hormones / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000009:adverse effects; D008297:Male; D011749:Pyrogens / Q000009:adverse effects; D051381:Rats; D013268:Stimulation, Chemical
D006728:Hormones; D008070:Lipopolysaccharides; D011749:Pyrogens; D003900:Desoxycorticosterone; D003300:Copper; D006854:Hydrocortisone