Endocrine pancreatic control of the release of gastric inhibitory polypeptide. A possible physiological role for C-peptide.
Intravenous infusion in anaesthetized rats of rat II C-peptide at a dose which produced circulating levels of 22.8 +/- 1.8 nmol/l after 30 min, resulted in a significant reduction (141 +/- 7 to 50 +/- 4 pmol/l, p < 0.001, mean +/- SEM) in the immunoreactive gastric inhibitory polypeptide response to an intestinal perfusion with a fat emulsion. Immunoreactive insulin levels were unchanged from basal in this study. It is suggested that C-peptide must be considered as a candidate for the endocrine pancreatic factor which exerts a negative feedback upon gastric inhibitory polypeptide release.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000494:pharmacology* / Q000502:physiology; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology; D005749:Gastric Inhibitory Polypeptide / Q000097:blood / Q000378:metabolism*; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism*; D007515:Islets of Langerhans / Q000502:physiology*; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D051381:Rats
D001786:Blood Glucose; D002096:C-Peptide; D005217:Fat Emulsions, Intravenous; D005768:Gastrointestinal Hormones; D007328:Insulin; D010455:Peptides; D005749:Gastric Inhibitory Polypeptide