[Suppressive effect of bone marrow cells from normal and leukemic mice on antibody production in culture of spleen cells in vitro].
The suppressive effect of bone marrow cells from AKR and (CBA X C57BL)F1 mice aged 2--10 months on the immune response of syngeneic spleen cells to sheep red blood cells in vitro was investigated. It was shown that the suppressive action of leukemic mice bone marrow cells greatly increases by the age of 9--10 months as compared to 2-month age. In (CBA X C57BL)F1 mice the suppressive acitivty of bone marrow remains unchanged over the same time period.
D000375:Aging; D000818:Animals; D000917:Antibody Formation; D001853:Bone Marrow / Q000254:growth & development / Q000276:immunology*; D016026:Bone Marrow Transplantation; D002478:Cells, Cultured; D007942:Leukemia, Experimental / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology*; D014185:Transplantation, Isogeneic
Suppressivnoe vliianie kletok kostnogo mozga normal'nykh i leikoznykh myshei na antitelogenez v kulture kletok selezenki in vitro.