Susceptibility of Clostridium botulinum to thirteen antimicrobial agents.
A total of 224 strains of Clostridium botulinum (including isolates from 14 patients with infant botulism and 4 with wound botulism) and 15 strains of C. sporogenes were tested by agar dilution for susceptibility to tetracycline, metronidazole, erythromycin, penicillin, rifampin, chloramphenicol, clindamycin, cephalothin, cefoxitin, vancomycin, sulfamethoxazole-trimethoprim, nalidixic acid, and gentamicin. At least 90% of the C. botulinum strains tested (except for nonproteolytic strains of toxin type F with penicillin) were susceptible to all drugs except sulfamethoxazole-trimethoprim, nalidixic acid, and gentamicin. Minimal inhibitory concentrations for strains from patients with infant and wound botulism were similar to those for other C. botulinum strains.
D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001906:Botulism / Q000188:drug therapy; D002440:Cefoxitin / Q000494:pharmacology; D002512:Cephalothin / Q000494:pharmacology; D002981:Clindamycin / Q000494:pharmacology; D003014:Clostridium botulinum / Q000187:drug effects*; D004917:Erythromycin / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D013420:Sulfamethoxazole / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010406:Penicillins; D002981:Clindamycin; D004917:Erythromycin; D002440:Cefoxitin; D014640:Vancomycin; D014295:Trimethoprim; D013752:Tetracycline; D013420:Sulfamethoxazole; D002512:Cephalothin