The effect of substituted phenothiazines on the mutagenicity of benzo[a]pyrene.
The effect of phenothiazine and 11 of its derivatives on the mutagenicity of benzo[a]pyrene, as measured by the Ames test was investigated. Significant anti-mutagenic activity was detected for 10 phenothiazine derivatives, with the 2-chloro derivative being the most effective inhibitor tested and promazine the only phenothiazine drug tested which has no demonstrable inhibitory activity. It is considered that the anti-mutagenic activity and therefore potentially anticarcinogenic activity of these derivatives should be of interest to epidemiologists.
D001580:Benzopyrenes / Q000378:metabolism*; D003864:Depression, Chemical; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism*; D010640:Phenothiazines / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000235:genetics; D013329:Structure-Activity Relationship
D001580:Benzopyrenes; D009153:Mutagens; D010640:Phenothiazines