Testing propafenone hydrochloride in the Ames Salmonella microsome system and in mammalian cytogenetic systems (bone marrow, spermatogonia).
2'-(2-Hydroxy-3-propylaminopropoxy)-3-phenyl-propiophenone-hydrochloride (propafenone-HCl, Rytmonorm) was tested for mutagenic activity in the Salmonella microsome system (Ames test) and in mammalian cell systems. Neither in the Ames test (62.5-1000 microgram/plate) nor in the bone marrow cells and spermatogonia of Chinese hamster (injected doses: 1.57, 3.13, 6.27 mg/kg) there is any evidence for an enhancement of mutation frequencies or chromosome aberration rates. Also, the micronucleus rates were in the control range. Under the experimental conditions of this investigations propafenone-HCl was not mutagenic.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects*; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects*; D009154:Mutation; D011405:Propafenone; D011427:Propiophenones / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects; D013093:Spermatogonia / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects*
D000889:Anti-Arrhythmia Agents; D011427:Propiophenones; D011405:Propafenone