Decreased cell division of the uterine luminal epithelium of diabetic rats in response to 17 beta-estradiol.
The uterine growth response to estradiol as determined by luminal epithelial cell division was measured in euglycemic and drug induced insulin deficient rats. The results demonstrated that uterine cell division in insulin deficient rats is depressed when compared to euglycemic rats. Replacement of insulin by osmotic minipumps (Alza Corporation) in insulin deficient rats restored the level of luminal cell division to those observed in euglycemic rats.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004848:Epithelium / Q000187:drug effects / Q000502:physiology; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007328:Insulin / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D014599:Uterus / Q000187:drug effects / Q000503:physiopathology*
D007328:Insulin; D004958:Estradiol