Clomipramine in the prevention of migraine.
Clomipramine was compared with placebo in the prevention of migraine headache. Both treatments reduced the frequency of attack markedly but there was no significant difference between the two. The severity of the attack was reduced in both cases but not significantly. The duration of attack was not affected. Significantly more side-effects were seen in the clomipramine group.
D000328:Adult; D002986:Clinical Trials as Topic; D002997:Clomipramine / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000517:prevention & control*; D010349:Patient Compliance
D002997:Clomipramine