[Functional activity of gonadal glandular cells in patients with testicular dysgenesis].
Results of histochemical study of testicular tissue in 31 patients, aged 2.5 to 31 years, suffering from dysgenesia syndrome of the testis are presented. Enzymes and lipids furnishing synthesis of steroid hormones (3-beta-oxysteroid dehydrogenase, alcohol dehydrogenase, glucose-6-phosphate dehydrogenase. NAD- and NADP-diaphorase, cholesterol and its esters) were revealed in Leydig's cells of pubertal-juvenile and adult patients, in Leydig's cells precursors in children, and also in Sertoli's cells of all these patients. All these cellular elements possessed high activity of the enzymes under study. It is suggested that Sertoli cells and Leydig's cells precursors, along with mature Leydig's cells, provide a sufficiently high functional activity of the gonads in patients with dysgenesia of the testis.
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000429:Alcohol Oxidoreductases / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D005958:Glucosephosphates; D006059:Gonadal Dysgenesis / Q000473:pathology*; D006153:Guanosine Diphosphate / Q000378:metabolism; D006801:Humans; D006914:Hydroxysteroids; D007985:Leydig Cells / Q000201:enzymology*; D008297:Male; D009243:NAD; D009249:NADP; D009252:NADPH Dehydrogenase / Q000378:metabolism; D012708:Sertoli Cells / Q000201:enzymology*; D013737:Testis / Q000473:pathology*
D005958:Glucosephosphates; D006914:Hydroxysteroids; D009243:NAD; D006153:Guanosine Diphosphate; D009249:NADP; D015096:3-Hydroxysteroid Dehydrogenases; D000429:Alcohol Oxidoreductases; D009252:NADPH Dehydrogenase; D008058:Dihydrolipoamide Dehydrogenase
O funktsional'nom aktivnosti zhelezistykh kletok gonad bol'nykh s sindromom disgenezii testikulov.