title: The genetic and cellular basis of regulation of the immune response to tumor antigens.
abstract: In this chapter I have dealt with the cellular and genetic basis of regulation of the immune response to tumor antigen. I have knowingly omitted discussion of effectors such as ADCC, NK, and B cells, since my own experience with such effectors relates primarily to early events associated with small-tumor inocula (Greenberg and Greene, 1976). In that model, NK and ADCC mechanisms, in which natural antibody and macrophages participate, are of importance and T cells are not. In the studies I have dealt with herein, more advanced tumor models have been evaluated. It is clear, I hope, from this chapter that understanding the pathways to immune-cell or Ts activation will provide the basis for applied immunotherapy techniques in the future.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000951:Antigens, Neoplasm / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D006649:Histocompatibility Antigens / Q000235:genetics; D006801:Humans; D007109:Immunity / Q000528:radiation effects; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D008211:Lymphocyte Cooperation; D008264:Macrophages / Q000276:immunology; D051379:Mice; D009101:Multiple Myeloma / Q000276:immunology; D009369:Neoplasms / Q000235:genetics / Q000276:immunology; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology; D014466:Ultraviolet Rays
chemical_list: D000951:Antigens, Neoplasm; D006649:Histocompatibility Antigens