Effect of immunoglobulin G on the responsiveness of human neutrophils to soluble staphylococcal protein A-induced neutrophil migration inhibition factor from T-lymphocytes.
Staphylococcal protein A is a bacterial cell wall product that binds human immunoglobulin G and thereby interferes with opsonization and phagocytosis of Staphylococcus aureus by neutrophils. Phagocytic cells are also responsive to various non-immunoglobulin lymphocyte mediators. We utilized the detection of a newly recognized mediator, a neutrophil migration inhibition factor from T-lymphocytes (NIF-T), to show that aggregates of staphylococcal protein A and immunoglobulins G could inhibit the responsiveness of neutrophils to NIF-T. That such aggregates may alter the responsiveness of neutrophils to lymphocyte mediators that amplify or modulate phagocytic functions may have important pathogenetic implications in staphylococcal infection.
D002478:Cells, Cultured; D003208:Concanavalin A / Q000276:immunology / Q000494:pharmacology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology; D007961:Leukocyte Migration-Inhibitory Factors / Q000276:immunology*; D008222:Lymphokines / Q000276:immunology*; D009194:Myeloma Proteins / Q000276:immunology; D009504:Neutrophils / Q000276:immunology*; D013205:Staphylococcal Protein A / Q000276:immunology* / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines; D009194:Myeloma Proteins; D013205:Staphylococcal Protein A; D003208:Concanavalin A