[Oral treatment of lamellar ichthyosis (non-bullous congenital ichthyosiform erythroderma) with an aromatic retinoid (author's transl)].
3 patients with lamellar ichthyosis have been treated orally with the aromatic retinoid Ro 10-9359 for periods of more than 2 years. This treatment resulted in a satisfactory improvement in the skin condition without any major side-effects. A light- and electron-microscopic study showed a marked decrease in the thickness of the lamellar stratum corneum without giving any clues concerning the mechanism of the therapeutic effect of this drug.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D005050:Etretinate / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007057:Ichthyosis / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D012867:Skin / Q000473:pathology / Q000648:ultrastructure; D014212:Tretinoin / Q000031:analogs & derivatives*
D014212:Tretinoin; D005050:Etretinate
Traitement oral de l'ichtyose lamellaire (erythrodermie ichtyosiforme congénitale non bulleuse) avec un rétinoïde aromatique. Etude clinique, microscopique optique et électronique d'un essai thérapeutique de plus de 2 ans.