Examination of dihydrotachysterol-induced progeria as a model for aging changes in carbohydrate metabolism.
Interest in the pharmacological effects of drugs in the elderly has created a need for a laboratory model in which responses of aged animals to drugs can be studied. Dihydrotachysterol (DHT)-induced progeria, a syndrome with symptoms similar to those seen in normal aging, was evaluated as an old age model. DHT-treatment was shown to produce a decreased carbohydrate tolerance that was due to an impaired release of insulin from pancreatic islets and not due to a decreased sensitivity to insulin. These changes were unlike those observed with aging. Thus, DHT-induced progeria would not appear to be a good model for aging for the investigation of carbohydrate metabolism. Evidence is presented which indicates that glucose and tolbutamide act via different mechanism to stimulate insulin release.
D000375:Aging; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D050260:Carbohydrate Metabolism; D004097:Dihydrotachysterol / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects; D005947:Glucose / Q000494:pharmacology; D007328:Insulin / Q000097:blood; D008297:Male; D008954:Models, Biological; D011371:Progeria / Q000139:chemically induced*; D051381:Rats; D013997:Time Factors; D014044:Tolbutamide / Q000494:pharmacology
D007328:Insulin; D014044:Tolbutamide; D005947:Glucose; D004097:Dihydrotachysterol