Effects of clonidine, guanethidine and furosemide on the development of vasopressin hypertension in rat.
The influence of clonidine, guanethidine and furosemide on the development of arterial hypertension was studied in rats with hypertension induced by repeated administration of lysine vasopressin. It was found that these drugs administered during long time periods together with lysine vasopressin prevented the development of arterial hypertension. When any of these drugs was given in combination with vasopressin plasma renin activity failed to rise and the level and turnover of catecholamines in rat brain were unchanged.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003000:Clonidine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005665:Furosemide / Q000008:administration & dosage*; D006145:Guanethidine / Q000008:administration & dosage*; D006973:Hypertension / Q000139:chemically induced / Q000517:prevention & control*; D008236:Lypressin / Q000009:adverse effects / Q000037:antagonists & inhibitors; D008297:Male; D051381:Rats; D013997:Time Factors; D000092502:Renin Inhibitors
D003000:Clonidine; D005665:Furosemide; D006145:Guanethidine; D008236:Lypressin; D000092502:Renin Inhibitors