title: Vaginal agenesis.
abstract: Development of the normal vagina is dependent on the mesonephric duct, paramesonephric duct, and urogenital sinus. A mesonephric anomaly may account for vaginal agenesis, and this defect also explains the associated genitourinary abnormalities. Patients usually present with primary amenorrhea and have a normal female phenotype with normal karyotype and hormonal function. Vaginal reconstruction has most commonly been carried out by use of a split-thickness skim graft with successful long-term results.
mesh_terms: D005260:Female; D006801:Humans; D016038:Skin Transplantation; D014182:Transplantation, Autologous; D014621:Vagina / Q000002:abnormalities* / Q000196:embryology / Q000601:surgery