[Chemotherapy of metastasizing colonic carcinomas with nitrosourea compounts. Retrospective analysis].
35 patients with advanced, and previously untreated, colorectal cancer underwent therapy with a combination of 5-fluorouracil, vincristine, DTIC, or one of the nitrosoureas, BCNU or methyl-CCNU, respectively. No complete remission was achieved. 33% of all cases resulted in partial remission and lasted for approximately 3--4 months. Complications were perilous such as neutro- and thrombocytopenia. The overal quality of life was poor. Though several parameters influence these results, we think that the above-listed nitrosoureas do not add substance to the chemotherapy of colorectal cancer.
D000328:Adult; D000368:Aged; D003110:Colonic Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009503:Neutropenia / Q000139:chemically induced; D009607:Nitrosourea Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D011788:Quality of Life; D013921:Thrombocytopenia / Q000139:chemically induced
D009607:Nitrosourea Compounds
Chemotherapie des metastasierten Kolonkarzinoms mit Nitroseharnstoffen.