[Protease as an immune response enhancer in immunization with an adsorbed staphylococcal anatoxin].
The injection of trypsin into rabbits immunized with adsorbed staphylococcal toxoid was found to have a potentiating effect on the immune response of the body, which was manifested by a considerable increase in the specific antibody titer and by the activation of nonspecific systemic protective factors. The intensity of antistaphylococcal immunity achieved by the moment of challenge (on day 23 of the experiment) in the animals ensured the resistance of the rabbits to staphylococcal test infection. The injection of trielin, a proteolysis inhibiting agent, simultaneously with the immunization of rabbits with adsorbed staphylococcal toxoid produced no such effect.
D000327:Adsorption; D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D007109:Immunity / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects; D007114:Immunization / Q000379:methods*; D010447:Peptide Hydrolases / Q000276:immunology*; D011817:Rabbits; D013208:Staphylococcal Toxoid / Q000008:administration & dosage*; D013997:Time Factors; D014357:Trypsin / Q000276:immunology; D014361:Trypsin Inhibitors / Q000276:immunology
D013208:Staphylococcal Toxoid; D014361:Trypsin Inhibitors; D010447:Peptide Hydrolases; D014357:Trypsin
Proteaza kak usilitel' immunogo otveta pri immunizatsii adsorbirovannym stafilokokkovym anatoksinom.