title: [Pharmacological properties of adicin, Soviet alpha-acetyldigitoxin].
abstract: Adicin, Soviet alpha-acetyldigitoxin, obtained from Digitalis lanata Ehrh., c. Scrophulariaceae after isolation from it of celanid is a highly effective cardiotonic of the digitalis type of action. It exerts a favourable ino- and tonotropic and an adverse chronotropic action on the heart. This action is brought up in varied animal species and can be observed for a long time (over 3 hours). Adicin produces no adverse effect on the coronary blood flow and it is conducive to the improvement of venous circulation. The drug does not differ considerably from acedoxin (Hungarian alpha-acetyldigitoxin) from the standpoint of the cardiotonic effect, cumulative properties, elimination rate, biological activity and toxicity. Adicin is recommended for clinical trials with a purpose of replacing imported drugs.
mesh_terms: D000112:Acetyldigitoxins / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002316:Cardiotonic Agents; D002415:Cats; D004074:Digitoxin / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D011817:Rabbits; D011898:Ranidae
chemical_list: D000112:Acetyldigitoxins; D002316:Cardiotonic Agents; D004074:Digitoxin
vernacular_title: Farmakologicheskie svoĭstva aditsina--otechestvennogo al'fa-atsetildigitoksina.