Stability of prostaglandin I2 in human blood.
Prostaglandin I2 (PGI2) is hydrolyzed more slowly in human plasma than in buffer at the same pH; this stabilization appears to be due to binding of PGI2 to albumin. The stability of the antiaggregatory potency of PGI2 is similar in human blood and in plasma buffered to pH 7.55. No measurable conversion of [3H]-PGI2 to radioactive or nonradioactive metabolites occurred during incubation with blood.
D000527:Alprostadil / Q000031:analogs & derivatives*; D004355:Drug Stability; D011464:Epoprostenol / Q000097:blood*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010974:Platelet Aggregation / Q000187:drug effects; D011453:Prostaglandins / Q000097:blood*; D011458:Prostaglandins E; D012709:Serum Albumin / Q000378:metabolism
D011453:Prostaglandins; D011458:Prostaglandins E; D012709:Serum Albumin; C022950:6-ketoprostaglandin E1; D011464:Epoprostenol; D000527:Alprostadil