[Metabolism and blood levels study of antidepressants: a rationale of their therapeutical use (author's transl)].
The authors show with some examples the interest of pharmacokinetics for the optimization of the therapeutical use of antidepressive agents. They give some indications about bioavailabilty, metabolism and half-life of these compounds and note the importance of the individual variations. They also analyze the studies on the possible relations between the clinical response and the steady-state plasma levels of the unchanged drug and/or its active metabolite. The relation between these two parameters would be linear for imipramine, amitriptyline, clomipramine, doxepine, dibenzepine, and curvilinear for nortriptyline, desipramine, protriptyline, maprotiline and mianserine, especially in endogenous depression. From a previous pharmacokinetic study calculations allow to predict the steady-state plasma concentrations. The question of the side effects and drug interactions is considered.
D000928:Antidepressive Agents / Q000008:administration & dosage / Q000097:blood*; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects / Q000097:blood / Q000378:metabolism; D001682:Biological Availability; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008099:Liver / Q000378:metabolism
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic
Etudu de métabolisme et des taux sanguins des antidépresseurs. Vers une rationalisation de leur emploi en thérapeutique.