title: Pitutary responsiveness to LH-RH, the occurrence of oestradiol- 17 beta-induced LH-positive feedback and the resumption of oestrous cycles in ewes post partum.
abstract: The relationship between pituitary responsiveness to exogenous LH-RH, return of oestradiol-17 beta-induced positive-feedback effect on LH release and the resumption of oestrous cycles were studied in Merino ewes lambing in the breeding season. The mean (+/- s.e.m.) increase in plasma LH 2 h after 50 micrograms LH-RH i.v. was reduced (P < 0.001) in ewes tested in the last 4 weeks of pregnancy (8.6 +/- 2.1 ng/ml, N = 29) but was similar (P > 0.05) for non-parturient dioestrous ewes (N = 31) and for anoestrous ewes tested around 14 (N = 50) and 28 (N = 51) days post partum (30 +/- 3.9, 37.8 +/- 4.0, 39. 0 +/- 3.2 ng/ml, respectively). Oestradiol-positive feedback was absent in 68.6% (35/51) and 54% (27/50) of ewes tested around 14 and 28 days post partum, respectively. Neither LH-RH responsiveness nor the presence of oestradiol-postive feedback was related to the incidence of 61.9%, 166/268) or interval to (62 +/- 2.2 days, N = 99) first oestrus post partum. We suggest that these endocrine responses do not represent factor limiting the resumption of ovarian cyclicity post partum.
mesh_terms: D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D004971:Estrus; D005246:Feedback; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D010902:Pituitary Gland / Q000187:drug effects* / Q000378:metabolism; D049590:Postpartum Period; D011247:Pregnancy; D012756:Sheep / Q000502:physiology*
chemical_list: D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D007986:Luteinizing Hormone