[Stimulation of nonspecific body resistance in transplantation].
The experiments on mice showed in principle a possibility of using prodigiozan, a stimulant of the host immunobiological reactivity together with immunodepressants in transplantation. Imuran in doses of 25 or 60 mg/kg and prednisolone in doses of 30 or 50 mg/kg were used on alternate days at a rate of 5 injections of every drug per course. Prodigiozan was administered intramuscularly in a dose of 0.5 mg/kg on the 4th and 8th-9th days of the immunodepressant administration. Addition of prodigiozan to the scheme of the combined use of the immunodepressants provided an increase in the survival rate of mice with staphylococcal and coli infections and prolongation of the skin allotransplant rejection time. No effect of prodigiozan on immune depression due to imuran was observed. The results suggest that screening of drugs for the use in transplanthology for prevention of infectious complications in the presence of immunostimulants is advisable among stimulants of the host nonspecific resistance.
D000818:Animals; D001379:Azathioprine / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004927:Escherichia coli Infections / Q000276:immunology; D007113:Immunity, Innate / Q000187:drug effects*; D007165:Immunosuppression Therapy / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D011239:Prednisolone / Q000276:immunology; D011354:Prodigiozan / Q000276:immunology; D016038:Skin Transplantation; D013203:Staphylococcal Infections / Q000276:immunology; D014181:Transplantation Immunology / Q000187:drug effects*; D014184:Transplantation, Homologous
D011354:Prodigiozan; D011239:Prednisolone; D001379:Azathioprine
Stimuliatsiia nespetsificheskoĭ rezistentnosti organizma pri transplantatsii.