Induction of hepatic drug metabolizing enzymes in mammals by pesticides: A review.
The induction of drug metabolizing enzymes in mammals is summarized including both enzymes of the cytochrome P-450-dependent microsomal mixed function oxidase system and glutathione S-transferases. Particular emphasis is placed on the role of pesticides as inducers, the early work being summarized while investigations carried out at North Carolina States University are considered in greater detail. Finally, the possible significance of induction is considered.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005982:Glutathione Transferase / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D010575:Pesticides / Q000494:pharmacology*; D010634:Phenobarbital / Q000494:pharmacology
D010575:Pesticides; D003577:Cytochrome P-450 Enzyme System; D005982:Glutathione Transferase; D010634:Phenobarbital