Renin-secreting tumor. Case report.
Renin-secreting tumor, though rare, should be considered in assessing severe hyperreninemic, hypertensive patients. We studied an 18-year-old girl with hypokalemic hyperreninemic hyperaldosteronism. No angiographic lesion could be detected. The plasma renin activity (PRA) of the right/left renal vein was 7.3. With a presumptive diagnosis of renin-secreting tumor (RST), the patient was operated on, and a cortical nodule was found on the right lower pole. Partial nephrectomy was followed by a rapid fall in PRA (half-life, 33-44 min) and normalization of blood pressure (BP). At 3 1/2 months postoperatively, the patient showed normotension, normokalemia, normal aldosterone, and slightly elevated PRA unresponsive to postural changes and furosemide treatment. Tumoral PRA secretion responded to postural stimulus, spironolactone use, and nitroprusside-induced hypotension. Neither the high aldosterone excretion nor hyperreninemia decreased after 3 days of DOCA; this agrees with a previously reported case suggesting the usefulness of this test in the diagnosis of RST.
D000293:Adolescent; D000450:Aldosterone / Q000097:blood / Q000652:urine; D001794:Blood Pressure / Q000187:drug effects; D003900:Desoxycorticosterone / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications / Q000188:drug therapy; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D007008:Hypokalemia / Q000150:complications* / Q000188:drug therapy; D007680:Kidney Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D009392:Nephrectomy; D012083:Renin / Q000097:blood / Q000378:metabolism*; D013148:Spironolactone / Q000627:therapeutic use
D013148:Spironolactone; D003900:Desoxycorticosterone; D000450:Aldosterone; D012083:Renin