title: Why are fetal muscles slow?
abstract: Differentiating fast and slow mammalian muscles contract slowly at birth and increase their speed during the first few weeks of life. However, only small proportions of slow myosin light chains are found in early developing muscles and the fast type of light chains predominate. In addition, differentiating muscle contains unique, embryonic forms of myosin which may partially determine the early slow responses. The present study suggests additional reasons for these slow twitch times. Most skeletal muscles are initially formed from a small population of primary generation cells which are innervated by pioneering axons early in myogenesis. Subsequently, numerous secondary generation cells develop along the walls of primary myotubes, then separate and become independent units of contraction. Using affinity-purified antibodies to fast and slow myosin, it was found that most primary myotubes react with anti-slow myosin and are destined to become slow, Type I fibres. By contrast, secondary generation cells stain exclusively with anti-fast myosin and develop into Type II, fast fibres. We propose that primary myotubes constitute the fundamental motor units of the developing neuromuscular system and are responsible for early slow movements. Secondary generation cells become organized into large, fast motor units later in development, eclipsing the original slow response.
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D007124:Immunoenzyme Techniques; D007527:Isoenzymes / Q000276:immunology; D009119:Muscle Contraction; D024510:Muscle Development; D009132:Muscles / Q000196:embryology*; D009218:Myosins / Q000276:immunology / Q000502:physiology*; D051381:Rats
chemical_list: D007527:Isoenzymes; D009218:Myosins