title: [Spina-bifida and anencephaly. Geographic distribution, correlation with HLA system (author's transl)].
abstract: Geographical variation in the incidence of an Anencephaly and Spina-Bifida is well documented. The highest rates for these malformations were found in Ireland, Wales, Scotland and in Western regions of England. These rates decrease progressively towards eastern Europe. In France the highest rates were found in some regions of Brittany. The geographical correlations between the mortality rates of Spina-Bifida and incidence of Spina-Bifida and Anencephaly and the HLA antigen frequencies are studied. There is a positive correlation with A1 and B8 and a negative one with B5 and BW35. The role of the HLA system in these associations is discussed.
mesh_terms: D000757:Anencephaly / Q000453:epidemiology* / Q000276:immunology; D005060:Europe; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D044469:Racial Groups; D016136:Spina Bifida Occulta / Q000453:epidemiology* / Q000276:immunology; D006113:United Kingdom
chemical_list: D006680:HLA Antigens
vernacular_title: Spina-bifida et anencéphalie. Répartition géograhique, corrélation avec le système HLA.