Antibiotic containing bone cement beads in the treatment of deep muscle and skeletal infections.
Forty-eight cases of osteomyelitis or bacterial arthritis operated on with eradication of infections lesions were randomly treated either by insertion of suction-irrigation drainage or by implantation of gentamicin beads. The average follow-up time was 2 years. There was no difference in the recurrence rate between the two groups. The gentamicin treated patients were however more easily cared for as the suction-irrigation drainage required constant attention. Local temporary treatment with gentamicin beads should be used in cases of deep gram-negative muscle and skeletal infections where it would otherwise be necessary to give toxic antibiotics.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001170:Arthritis, Infectious / Q000188:drug therapy*; D001843:Bone Cements; D002648:Child; D002986:Clinical Trials as Topic; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy*; D011897:Random Allocation; D013396:Suction; D007507:Therapeutic Irrigation
D000900:Anti-Bacterial Agents; D001843:Bone Cements; D005839:Gentamicins