[Activity of granulocyte proteinases and level of acid-stable proteinase inhibitors in the bronchial secretions of children with bronchopathies of different etiology].
Activities of elastase- and trypsin-like proteinases from granulocytes as well as content of their acid-stable inhibitors were studied in 80 samples of the bronchial secretory products obtained from 34 children from 4 to 15 years old suffering from various forms of bronchopulmonary pathology/primary chronic pneumonia, Cartagener's syndrom, mucoviscidosis, pulmonary malformations. Normal bronchial secretory products were characterized by high content of the acid-stable inhibitors as well as by absence of the granulocytic proteinases activity. Development of inflammatory impairments in bronchi was accompanied by 2-3-fold decrease in content of the inhibitors with simultaneous increase in the enzymatic activity. The data obtained suggest that the relationship between activity of granulocytic proteinases and content of acid-stable inhibitors in bronchial secretory products might be considered as an important index of inflammatory processes in bronchi. De novo synthesis of acid-stable inhibitors in lungs appears to be decreased in the course of development of inflammation.
D000293:Adolescent; D001980:Bronchi / Q000378:metabolism*; D001982:Bronchial Diseases / Q000201:enzymology*; D001984:Bronchial Neoplasms / Q000201:enzymology; D001991:Bronchitis / Q000201:enzymology; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000201:enzymology; D010450:Endopeptidases / Q000378:metabolism*; D006098:Granulocytes / Q000201:enzymology*; D006801:Humans; D007619:Kartagener Syndrome / Q000201:enzymology; D008168:Lung / Q000002:abnormalities; D011014:Pneumonia / Q000201:enzymology; D011480:Protease Inhibitors / Q000032:analysis*; D012507:Sarcoidosis / Q000201:enzymology
D011480:Protease Inhibitors; D010450:Endopeptidases
Aktivnost' proteinaz granulotsitov i uroven' kislotostabil'nykh ingibitorov proteinaz v bronkhial'nom sekrete deteĭ s bronkhopatiiami razlichnoĭ étiologii.