HLA-DR antigens in insulin-dependent diabetes.
HLA-A, B, C, and DR-typing was performed in 51 children with insulin-dependent diabetes. A close association between childhood diabetes and HLA-DR3 and DR4 was established. DR3 was found in 55% and DR4 in 75% of the diabetic children, compared with 20% and 26% respectively in healthy controls. The combination of DR3 and DR4 was present in 37% of the diabetic children compared with only 4% of the controls. This investigation provides strong evidence that the susceptibility genes for insulin-dependent diabetes are in close linkage disequilibrium with the HLA-DR locus. In diabetic children DR4 seems to be a more important susceptibility factor than in patients with manifestation of insulin-dependent diabetes after 15 years.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008297:Male
D000949:Histocompatibility Antigens Class II; D007328:Insulin