title: ICI 35868 (Diprivan): a new intravenous anaesthetic. A comparison with Althesin.
abstract: ICI 35868 (Diprivan), 1-2 mg/kg was used to induce anaesthesia in 20 patients, and the results compared with induction of anaesthesia by Althesin 0.5 ml/kg given to a similar group of 20 patients. ICI 35868 was effective in inducing anaesthesia, but produced more respiratory depression, and cardiovascular effects which were significantly different from those produced by Althesin. ICI 35868 gave a smoother induction. It is concluded that ICI 35868 is a promising new induction agent which may also find application for the maintenance of anaesthesia.
mesh_terms: D000328:Adult; D000530:Alfaxalone Alfadolone Mixture / Q000494:pharmacology; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000494:pharmacology; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D010636:Phenols / Q000494:pharmacology; D015742:Propofol; D012119:Respiration / Q000187:drug effects
chemical_list: D000777:Anesthetics; D010636:Phenols; D000530:Alfaxalone Alfadolone Mixture; D015742:Propofol