title: [Disopyramide poisoning].
abstract: Acute intoxications with the antiarrhythmic drug disopyramide (Norpace) are often life-threatening. After an almost asymptomatic interval of 1 to 4 hours, cardiogenic shock of sudden onset occurs. The usual methods of cardiac resuscitation such as adrenaline and antiarrhythmic drugs should not be used, and transvenous pacemakers often prove ineffective. To lower the high rate of mortality, early appropriate monitoring and facilities for rapid intervention are necessary. Isoprenaline is the most suitable positive inotropic and chronotropic drug. Hemoperfusion with Amberlite XAD 14 is effective but not always needed.
mesh_terms: D000136:Acid-Base Equilibrium; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D004206:Disopyramide / Q000506:poisoning*; D006352:Heart Ventricles; D006464:Hemoperfusion; D006801:Humans; D007545:Isoproterenol / Q000627:therapeutic use; D011188:Potassium / Q000378:metabolism; D011725:Pyridines / Q000506:poisoning*; D012770:Shock, Cardiogenic / Q000139:chemically induced*; D014693:Ventricular Fibrillation / Q000139:chemically induced
chemical_list: D011725:Pyridines; D004206:Disopyramide; D007545:Isoproterenol; D011188:Potassium
vernacular_title: Disopyramidvergiftung.