The role of H-2 regions in overcoming tissue incompatibility.
Neonatal transplantation tolerance to the products of the H-2 beta complex was induced in B10.A (H-2 alpha) mice. On the basis of the survival of skin allografts it was found that antigens determined by the D region of the H-2 alpha complex (of the B10.A(2R) strain) were most easily overcome and that tolerance to the products of the D end of the H-2 complex (of the B10.A(4R) strain) was also easy to induce. The antigens produced by the K end of H-2 (of the B10.A(5R) and B10.A(3R) strains) represented a stronger incompatibility barrier and a difference in the entire H-2 beta complex caused strongest resistance to tolerance induction. When tolerance to the products of the entire H-2 beta complex was induced in newborn B10.A mice, and the neonatally treated animals were grafted simultaneously with five different grafts, those disparate at the K end of H-2 and in the entire H-2 region were rejected in some animals, while the grafts disparate at the D end of H-2 remained intact in the same mice. No dependence on the I-J subregion was observed in this system. Furthermore, tolerance was more easily inducible in male than in female B10.A mice.
D000818:Animals; D005260:Female; D006085:Graft Survival; D006183:H-2 Antigens / Q000235:genetics*; D007108:Immune Tolerance; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D006183:H-2 Antigens