title: Mutagenicity of aerosols from the oxidative thermal decomposition of rigid polyurethane foam.
abstract: The aerosol fraction of the oxidative thermal decomposition products (700 degrees C) of rigid polyurethane foam was collected on glass fiber filters and fractionated into either-soluble neutral, acidic, and basic fractions and water-soluble compounds. The fractions showed mutagenic activity in a bacterial fluctuation test with Salmonella typhimurium TA98 or Escherichia coli CM891 as the tester strains. All the fractions induced mutations in both strains after metabolic activation with rat liver S-9 mix. The basic and the water-soluble fractions were mutagenic for S. typhimurium TA 98 even without activation. Thin-layer chromatography showed the presence of several primary aromatic amines in the aerosol. Polycyclic aromatic hydrocarbons were not detected by glass capillary gas chromatogaphy.
mesh_terms: D000336:Aerosols; D004926:Escherichia coli / Q000235:genetics; D005390:Fires; D009152:Mutagenicity Tests; D009153:Mutagens; D010084:Oxidation-Reduction; D011140:Polyurethanes / Q000032:analysis / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000235:genetics
chemical_list: D000336:Aerosols; D009153:Mutagens; D011140:Polyurethanes