Pyrazole-insensitive alcohol dehydrogenase activity in human serum.
Serum alcohol dehydrogenase (ADH) activity in some individuals contains a fraction that is not inhibited by pyrazole. This might be due to the presence in those sera of pi-ADH, a unique isoenzyme found recently in human liver, and which, according to one hypothesis, could be co-responsible for the development of alcohol dependence.
D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D011720:Pyrazoles / Q000494:pharmacology*
D007527:Isoenzymes; D011720:Pyrazoles; D000429:Alcohol Oxidoreductases