Experiences in the insulin requirement of diabetics.
Using the artificial endocrine pancreas the insulin requirement of diabetics was determined on a standard diet during a fasting period of 12 hours or a 6-hour resting fasting period in the night. Values characteristic of the individual type of diabetes ranging from 507 mU/h to 1410 mU/h were found. The basal and the modulating insulin requirement were both determined. A considerable diurnal variation of the modulating insulin-requirement was demonstrated with the highest value in the morning and the lowest in the evening. In order to cover the basal insulin requirement the corresponding quantity of a very long acting insulin was given with supplements of short acting insulin 2--5 times during the day to obtain a continuous normoglycaemic state. This procedure proved to be optimal in the treatment of pregnant diabetics.
D000293:Adolescent; D000328:Adult; D001331:Automation; D001510:Bed Rest; D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005215:Fasting; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D008875:Middle Aged; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000378:metabolism
D001786:Blood Glucose; D007328:Insulin