[Results of selection for affinity in cell populations of rat transplantable tumors].
Results of selection for the affinity for lung tissue in cells of three transplanted tumors of the rat are given. Tumor cell suspensions were injected intravenously-intraperitoneally or subcutaneously-intravenously (the clonal line -- clone circuit), or intravenously-intravenously (the clone-clone circuit). The efficiency of the method has been shown in the cases of the Worker carcinoma and of a 20-methylcholantren-induced rhabdosarcoma. A 10-fold recloning of cells of the ovary ascite tumor failed to increase their affinity for the lung tissue. It is suggested that a hereditary heterogeneity with the trait "the affinity for lung tissue" may be characteristic of tumor cell populations.
D000818:Animals; D002279:Carcinoma 256, Walker / Q000235:genetics; D002460:Cell Line; D002478:Cells, Cultured; D002999:Clone Cells / Q000166:cytology; D003114:Colony-Forming Units Assay; D005260:Female; D008175:Lung Neoplasms / Q000235:genetics; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000235:genetics*; D009928:Organ Specificity; D010051:Ovarian Neoplasms / Q000235:genetics; D051381:Rats; D012208:Rhabdomyosarcoma / Q000235:genetics; D012641:Selection, Genetic
Rezul'taty otbora na affinitet v kletochnykh populiatsiiakh nekotorykh transplantruemykh opukholeĭ krys.