[Detection of antitumor-antibodies in patients with tonsillar carcinoma (author's transl)].
48 patients with squamous cell carcinoma of the tonsil were tested for autologous and allogeneic antitumor-antibodies directed against squamous cell carcinoma cells. The use of autologous serum avoids the need of absorption. Antibodies detected at the time of tumor extirpation could also be used to label their specific antigen of cells from swabs of the oral cavity. Such a surface fluoreszens appeared in 5 patients between 3 and 6 months before recurrency and could be followed during the whole course of disease. Besides very low amounts of antibodies of the IgA- and IgM-class the main portion was IgG. While these antibodies reacted in a similar degree with allogeneic tonsillar carcinomas cross reaction with other allogeneic tumor cells (bladder--kidney carcinoma) could not be detected.
D000912:Antibodies, Neoplasm / Q000032:analysis*; D000918:Antibody Specificity; D002294:Carcinoma, Squamous Cell / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D009364:Neoplasm Recurrence, Local / Q000276:immunology; D014067:Tonsillar Neoplasms / Q000276:immunology*
D000912:Antibodies, Neoplasm; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Nachweis von Antitumor-Antikörpern bei Patienten mit Tonsillenkarzinom.