[Obstructive peripheral athero-arteriosclerotic vascular diseases. Apparent pathogenetic role of hormono-metabolic changes].
We determined by comparison, in 30 patients with arteriosclerosis obliterans and in 10 normal peoples, 50-70 years aged, the values of some glycolipidic parameters (blood glucose, triglyceridemia, cholesterolemia, nephaemia, beta- and pre-beta-lipoproteinemia) and moreover the hormonal ones (IRI, GH, cortisolemia) at fast in the morning, during the whole day and during some blocking and stimulating tests. Patients with arteriosclerosis obliterans presented a significant alteration of the lipidic outline (hyper-lipoproteinemia of IV type sec. Fredr) and of the carbohydrate metabolism, emphasized at the OGTT by a dissimilar tolerance (normal, borderline and pre-diabetic type) referring to a normal high and low insulin immission respectively. We dissert widely about biohumural data, as reflexes involved from the pancreatic function and from the ischaemic process, and we report the eventual tie between the detected hormone-metabolic disorders and the development of arteriosclerotic occlusive disease in the lower extremities.
D000368:Aged; D001157:Arterial Occlusive Diseases / Q000209:etiology* / Q000378:metabolism; D001162:Arteriosclerosis Obliterans / Q000209:etiology / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002784:Cholesterol / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006023:Glycoproteins / Q000097:blood; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D006949:Hyperlipidemias / Q000150:complications; D006953:Hyperlipoproteinemia Type IV / Q000150:complications; D007328:Insulin / Q000097:blood*; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006023:Glycoproteins; D007328:Insulin; D008074:Lipoproteins; D014280:Triglycerides; D013006:Growth Hormone; D002784:Cholesterol; D006854:Hydrocortisone
Vasculopatie periferiche ostruttive atero-arteriosclerotiche. Apparente ruolo patogenetico di alcune alterazioni ormono-metaboliche.