title: Programmable open-loop micropump insulin delivery system.
abstract: The application of "closed-loop" glucose-controlled insulin infusion in metabolic research and in the management of diabetic patients in acute emergency situations has stimulated the development of portable insulin infusion devices intended for the long-term stabilization of glucose levels. Since in vivo glucose sensors with long-term accuracy and reliability are not yet available, the currently projected portable insulin infusion systems are the "open-loop" type. Such systems should be reliable, safe, programmable, lightweight, and small in size. In addition, the power requirements should be as low as possible to avoid the need for heavy batteries and/or periodic recharging. In turn, these requirements govern the design criteria for the most essential component of such an instrument, the insulin delivery pump. A micropump has been developed in an attempt to meet all desirable design features. Evaluation data are presented.
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000188:drug therapy*; D004582:Electronics, Medical / Q000295:instrumentation*; D006801:Humans; D007263:Infusions, Parenteral / Q000295:instrumentation*; D007328:Insulin / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D001786:Blood Glucose; D007328:Insulin