[Regulation of alkaline exoprotease and cephalosporin C synthesis in Acremonium chrysogenum by different carbon and nitrogen sources].
The synthesis of exoproteases and cephalosporin C in Acremonium chrysogenum is repressed by easily assimilated forms of nitrogen and carbon according to the type of nitrogen metabolism repression and catabolism inhibition. Glucose and ammonium salts inhibited the mycelium fragmentation and prevented formation of conidia. Amino acids had a diverse effect on the synthesis of the proteases and antibiotic. Methionine played the role of an inductor of the synthesis of alkaline exoproteases, cephalosporin C and the mycelium fragmentation into arthrospores.
D002244:Carbon / Q000378:metabolism*; D002511:Cephalosporins / Q000096:biosynthesis*; D003470:Culture Media; D004790:Enzyme Induction / Q000187:drug effects; D003904:Mitosporic Fungi / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D009584:Nitrogen / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000096:biosynthesis*
D002511:Cephalosporins; D003470:Culture Media; D002244:Carbon; D010447:Peptide Hydrolases; D009584:Nitrogen
Reguliatsiia razlichnymi istochnikami ugleroda i azota sinteza shchelochnykh ékzoproteaz i tsefalosporina C u Acremonium chrysogenum.