Disturbances of metabolism and cardiac function under the action of emotional painful stress and their prophylaxis.
Under the action of severe emotional painful stress the high concentration of catecholamines leads to the activation of peroxide oxidation of lipids in myocardium. Lipid peroxides affect membranes, responsible for the transport of calcium. As a result local necrobiosis and disturbances of the contractile function of the heart are developed. This emotional painful stress is regularly followed by activation of the inhibitory GABA-ergic system of the animal brains, which restricts the intensity and the time of stress syndromes. The injection of one of the metabolites of GABA-ergic system - gamoxibutirate (GOBA) - prior to stress essentially decreases the intensity of stress syndrome and prevents the stress affection of the heart muscle.
D000818:Animals; D001008:Anxiety Disorders / Q000517:prevention & control*; D002118:Calcium / Q000378:metabolism; D002395:Catecholamines / Q000502:physiology; D002540:Cerebral Cortex / Q000378:metabolism; D005938:Glucocorticoids / Q000502:physiology; D005971:Glutamates / Q000378:metabolism; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D006885:Hydroxybutyrates / Q000096:biosynthesis; D007656:Ketoglutaric Acids / Q000378:metabolism; D050356:Lipid Metabolism; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D013315:Stress, Psychological / Q000503:physiopathology*; D013386:Succinates / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis
D002395:Catecholamines; D005938:Glucocorticoids; D005971:Glutamates; D006885:Hydroxybutyrates; D007656:Ketoglutaric Acids; D013386:Succinates; D005680:gamma-Aminobutyric Acid; D002118:Calcium