Immunologically induced tubulo-interstitial nephritis: experimental models in rats.
Experimental models of immunologically induced tubulo-interstitial nephritis (TIN) in rats are described. Antitubular basement membrane (anti-TBM) nephritis was demonstrated to be a TIN resulting from an antigen antibody reaction. Renal transplant rejection and the local graft-vs-host (GVH) reaction were cell-mediated immune reactions in which the antigen was possibly shared by kidney structures. A cellular immune reaction to locally applied antigens was shown to be the basis for another experimental model of TIN, possibly originating from activated mediator systems.
D000818:Animals; D000917:Antibody Formation; D001485:Basement Membrane / Q000276:immunology; D004195:Disease Models, Animal; D006087:Graft vs Host Reaction; D007111:Immunity, Cellular; D016030:Kidney Transplantation; D007684:Kidney Tubules / Q000276:immunology; D009395:Nephritis, Interstitial / Q000276:immunology*; D051381:Rats; D014184:Transplantation, Homologous