title: The immunoregulatory role of antigen-antibody complexes. I. Assessment of B and T-cell responses.
abstract: The capacity of ovalbumin-anti-ovalbumin complexes to prime T cells preferentially without concomitant induction of antibody synthesis was investigated. Whereas free antigen injection into mice primed T and B lymphocytes and induced antibody production, injection of antigen-antibody complexes did not result in antibody production but did result in T-cell priming. However, the data suggest that, notwithstanding the lack of induction of antibody synthesis by immune complexes, a low degree of B-cell priming by the complex occurred; this priming was of IgM precursors only. The results indicate that the immunoglobulin isotype composition of the complex may be important to this preferential effect.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000936:Antigen-Antibody Complex; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D006462:Hemolytic Plaque Technique; D007112:Immunity, Maternally-Acquired; D007075:Immunoglobulin M / Q000276:immunology; D051379:Mice; D010047:Ovalbumin / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000936:Antigen-Antibody Complex; D007075:Immunoglobulin M; D010047:Ovalbumin