Anti-HLA-A, B, C and DR antibodies in renal transplant recipients.
Anti-HLA-A, B, C and DR antibodies in 173 sera derived form renal transplant recipients were examined, using the cytotoxicity techniques standardized at the 8th International Histocompatibility Workshop. About 50% of sera obtained within 6 months of transplantation showed anti-HLA-DR antibodies. Thereafter, serum anti-DR antibodies were found in about 30% of the examined sera. However, at more than 3 years after transplantation, the reappearance of anti-DR antibodies was noted in more than 60% of the examined sera. Anti-HLA-A, B and C antibodies were not found except in the sera from recipients with irreversible rejection. The post-transplant production of anti-DR antibodies against incompatible donor HLA-DR antigens was confirmed in sera derived repeatedly from the same patients.
D000328:Adult; D000917:Antibody Formation; D000918:Antibody Specificity; D003602:Cytotoxicity, Immunologic; D006680:HLA Antigens / Q000032:analysis*; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D007518:Isoantibodies / Q000032:analysis*; D016030:Kidney Transplantation; D008297:Male; D014184:Transplantation, Homologous
D006680:HLA Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D007518:Isoantibodies