title: Long-term safety of benoxaprofen.
abstract: Adverse experiences were monitored in 1,681 patients with rheumatoid arthritis (RA) or osteoarthritis to evaluate the safety of benoxaprofen at daily doses up to 1,000 mg during long-term therapy. Gastrointestinal side effects with benoxaprofen compared favorably to those reported during aspirin and ibuprofen therapy, with peptic ulcers reported in 0.4% of the patients or 1 ulcer for 200 patient years. The incidence of photosensitivity or onycholysis was 9%. Laboratory examinations revealed no significant changes in BUN, hematocrit, hemoglobin, SGOT, and SGPT values. The only trend toward abnormal values was seen in the LDH in patients with RA.
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000633:toxicity*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001241:Aspirin / Q000633:toxicity; D001583:Benzoxazoles / Q000633:toxicity*; D001806:Blood Urea Nitrogen; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D006801:Humans; D007052:Ibuprofen / Q000633:toxicity; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009260:Nail Diseases / Q000139:chemically induced; D010003:Osteoarthritis / Q000188:drug therapy*; D010437:Peptic Ulcer / Q000139:chemically induced; D010787:Photosensitivity Disorders / Q000139:chemically induced; D011422:Propionates / Q000633:toxicity*; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D001583:Benzoxazoles; D011422:Propionates; C011677:benoxaprofen; D007770:L-Lactate Dehydrogenase; D001241:Aspirin; D007052:Ibuprofen