[Effect of truncal vagotomy on insulin secretion and prostaglandin E2 concentration in the peripheral blood of rats].
Immunoreactive insulin, glucose and prostaglandin E2 blood content was studied in rats after truncal vagotomy. It was shown that the content of blood plasma glucose did not change after the operation. On the 2nd postoperative day, the content of insulin was similar to that in sham-operated animals. It slightly decreased by the 14th postoperative day and physiologically remained within normal. The level of PGE2 rose abruptly on the second day and fell insignificantly on the 14th day, but did not reach the level recorded in sham-operated rats. Since secreted insulin provides normoglycemia in rats, it can be inferred that function of the insular apparatus is not disturbed after vagotomy over the experimental period. It is suggested that elevated output of PGE2 induced by vagotomy may be in favour of exogenous application of prostaglandins to depress gastric secretion.
D000818:Animals; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000294:innervation* / Q000378:metabolism; D008297:Male; D011458:Prostaglandins E / Q000097:blood*; D051381:Rats; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*
D007328:Insulin; D011458:Prostaglandins E
Vliianie stvolovoĭ vagotomii na sekretsiiu insulina i soderzhanie prostaglandinov E2 v perifericheskoĭ krovi krys.