[Effect of anti-donor lymphocyte globulin on renal xenograft survived (author's transl)].
This paper reports about experimental xenografting of kidneys in closely related species (fox-dog) modifying primary rejection by treatment of the recipients with anti-donor lymphocyte globulin (ADLG). In respect of the phylogenetic constellations, ADLG contains lymphocytotoxic and hemagglutinating antibodies reactive in vitro with lymphocytes and erythrocytes of foxes as well as of dogs. Furthermore, donor species-specific papain-separated lymphocyte antigen is capable of reducing cytotoxicity of ADLG by adsorption of its lymphocytotoxic antibodies. In vivo ADLG, used as single therapy, has an immunosuppressive effect on kidney graft survival, which results in significant prolongation of mean survival time (9.6 +/- 1.5 days, n = 5).
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology*; D004285:Dogs; D005589:Foxes; D006085:Graft Survival / Q000187:drug effects*; D016030:Kidney Transplantation; D014183:Transplantation, Heterologous
D000961:Antilymphocyte Serum
Modifizierung der Primärabstossung xenogener Nierentransplantate durch Anti-Donor-Lymphozyten-Globulin.