Polyclonal activation of murine B lymphocytes by Fc fragments. III. Characterization of the defect in the ability of the C3H/HeJ mouse to respond to Fc fragments.
Spleen cell preparations from the C3H/HeJ mouse were found to be refractory to Fc fragment-induced polyclonal activation. This defect was not a characteristic of all C3H strains, because spleen cells from the histocompatible C3Heb/FeJ strain produced polyclonal antibody in the presence of Fc fragments. The cellular defect was found to be associated with the macrophage population. Macrophages from C3H/HeJ mice were incapable of generating mitogenic Fc subfragments from intact Fc, whereas C3Heb/FeJ performed this function normally. That T cells and B cells from the C3H/HeJ mouse were normal was shown by the fact that C3H/HeJ spleen cells responded to Fc subfragments. Moreover, T cells from C3H/HeJ spleen cell populations could be substituted for C3Heb/FeJ-derived T cells.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D002999:Clone Cells / Q000276:immunology; D007141:Immunoglobulin Fc Fragments; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009163:Mycobacterium bovis / Q000276:immunology; D011817:Rabbits; D013154:Spleen / Q000276:immunology
D007141:Immunoglobulin Fc Fragments