In vitro and in vivo removal of anti-A erythrocyte antibody by adsorption to a synthetic immunoadsorbent.
A solid-phase immunoadsorbent column using blood group A trisaccharide was tested in vitro and in vivo in dogs. This column was demonstrated to specifically remove anti-A antibody from human plasma in vitro and in vivo dogs specifically immunized with synthetic human blood group A trisaccharide. These studies indicate that this technique will be useful in removing anti-A and B antibody in marrow transplant recipients of incompatible marrow.
D000017:ABO Blood-Group System; D000818:Animals; D004285:Dogs; D006801:Humans; D007163:Immunosorbent Techniques; D007518:Isoantibodies / Q000302:isolation & purification*
D000017:ABO Blood-Group System; D007518:Isoantibodies