Stimulation of anti-aggregatory activity from rat aorta by hypolipidemic drugs.
The effect of clofibrate, clofibric acid and nicotinic acid on the ability of rat aortas to synthesize prostacyclin-like biological material is reported. Dissected and washed aortas of rats, treated with these drugs showed a markedly higher capacity to synthesize acid-labile prostacyclin-like activity than those of untreated controls. The investigated drugs may thus not only exert their influence on plasma lipid metabolism but also on the inhibition of platelet thrombi formation in the treatment of atherosclerotic diseases.
D000818:Animals; D001011:Aorta; D002417:Cattle; D002994:Clofibrate / Q000031:analogs & derivatives* / Q000494:pharmacology*; D002995:Clofibric Acid / Q000494:pharmacology*; D011464:Epoprostenol / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008055:Lipids / Q000097:blood; D008297:Male; D009539:Nicotinic Acids / Q000494:pharmacology*; D010431:Pentoxifylline / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats
D008055:Lipids; D009539:Nicotinic Acids; D002995:Clofibric Acid; D011464:Epoprostenol; D002994:Clofibrate; D010431:Pentoxifylline