Treatment of Klebsiella pneumoniae respiratory tract infection of squirrel monkeys with aerosol administration of kanamycin.
The therapeutic efficacy of IM-administered kanamycin was compared with the efficacy of aerosol-administered kanamycin in Klebsiella pneumoniae-infected squirrel monkeys. Differences in mortality or morbidity were not seen with equivalent dosages of antibiotic ranging from 15 to 6.9 mg/kg of body weight/day. Seemingly, the IM route of kanamycin administration was as effective as the aerosol route for therapy.
D000336:Aerosols; D000818:Animals; D002427:Cebidae; D007273:Injections, Intramuscular; D007612:Kanamycin / Q000008:administration & dosage* / Q000627:therapeutic use; D007710:Klebsiella Infections / Q000188:drug therapy / Q000662:veterinary*; D007711:Klebsiella pneumoniae; D008297:Male; D008992:Monkey Diseases / Q000188:drug therapy*; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000662:veterinary*; D012453:Saimiri
D000336:Aerosols; D007612:Kanamycin