Paracetamol does not potentiate the acetylsalicylate inhibition of prostaglandin release from macrophages.
Prostaglandin (PGE2 and PGI2) synthesis can be stimulated in macrophages by the tumour promotor 12-O-tetradecanoylphorbol-13-acetate (TPA) and inhibited by acetylsalicyclic acid (IC50 = 8.2 x 10(-6) M) and paracetamol (IC50 = 1.9 x 10(-4) M). When mixture of both drugs were tested only an additive effect was observed. This result is in contrast to recent reports describing both potentiation of acetylsalicylate-induced PG synthesis inhibition and enhancement of PG production by paracetamol.
D000082:Acetaminophen / Q000494:pharmacology*; D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D004357:Drug Synergism; D011464:Epoprostenol / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D010703:Phorbol Esters / Q000494:pharmacology; D011453:Prostaglandins / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism
D010703:Phorbol Esters; D011453:Prostaglandins; D011458:Prostaglandins E; D000082:Acetaminophen; D011464:Epoprostenol; D001241:Aspirin