Antagonism of ethanol narcosis in mice by hyperbaric pressures of 4-8 atmospheres.
Hyperbaric treatment with 100% oxygen or oxygen-helium mixtures at 4-8 atmospheres absolute significantly reduced ethanol sleep-time and increased wake-up blood ethanol concentrations in C57 mice. The results indicate that the antagonism does not result from direct effects of oxygen nor from enhanced ethanol elimination, but appears to involve a direct effect of hyper-baric treatment.
D000818:Animals; D001274:Atmospheric Pressure; D000431:Ethanol / Q000037:antagonists & inhibitors* / Q000097:blood; D008297:Male; D051379:Mice; D012890:Sleep / Q000187:drug effects*
D000431:Ethanol