The use of prostacyclin in preventing occlusion of microvascular anastomoses by platelet thrombus: an experimental study in rats.
A pilot study was carried out to assess the value of Prostacyclin in presenting the occlusion of microvascular anastomoses by platelet thrombus using the femoral vein of the rat as the experimental model. This study showed a much higher patency rate in those anastomoses bathed in a solution of Prostacyclin compared with the control group. The difference was statistically significant. The use of Prostacyclin to prevent platelet thrombus occlusion in man requires investigation but may be limited by the short half-life of the solution.
D000818:Animals; D011464:Epoprostenol / Q000627:therapeutic use*; D005263:Femoral Artery / Q000601:surgery*; D008866:Microsurgery; D010865:Pilot Projects; D011183:Postoperative Complications / Q000517:prevention & control*; D011453:Prostaglandins / Q000627:therapeutic use*; D051381:Rats; D013927:Thrombosis / Q000517:prevention & control*
D011453:Prostaglandins; D011464:Epoprostenol