title: Pyrazolopyrimidine metabolism in African trypanosomes: metabolic similarities to Trypanosoma cruzi and Leishmania spp.
abstract: Growth inhibition and radioisotope incorporation studies with allopurinol (4-hydroxypyrazolo(3,4-d)pyrimidine) have shown that the African trypanosomes are biologically and biochemically similar to Leishmania spp. and Trypanosoma cruzi with respect to their response to this compound. These organisms, as a group, share the unique ability to convert allopurinol sequentially to its ribonucleoside monophosphate and 4-aminopyrazolo(3,4-d)pyrimidine ribonucleoside mono-, di- and triphosphates.
mesh_terms: D000493:Allopurinol / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D007891:Leishmania / Q000378:metabolism; D014345:Trypanosoma / Q000187:drug effects / Q000378:metabolism*; D014346:Trypanosoma brucei brucei / Q000187:drug effects / Q000378:metabolism*; D014349:Trypanosoma cruzi / Q000378:metabolism
chemical_list: D000493:Allopurinol