Sympathoadrenal and renin-angiotensin systems in the development of two-kidney, one clip renal hypertension in rats.
The relative roles of the sympathetic nervous system and renin-angiotensin system in the development of two-kidney renal hypertension were studied using four groups of rats: Group I = vehicle control; Group II = 6-OH-dopamine (2 weeks prior to renal clipping then weekly throughout the study); Group III = adrenal medullectomy plus vehicle; Group IV = 6-OH-dopamine plus adrenal medullectomy. Six weeks after clipping of a single renal artery, plasma renin activity (PRA) was comparably elevated in all groups. However, mean blood pressure (MBP) of Group II was lower than that of Group I controls (154.7 +/- 6.8 vs 197.3 +/- 6.6 mm Hg respectively). The MBP of Group III (207.0 +/- 5.2 mm Hg) was not different from that of Group I whereas in Group IV (134.2 +/- 18.0 mm Hg) it was markedly lower. All groups of rats were given a single dose of captopril (30 mg/kg p.o.) to inhibit the renin-angiotensin system. Despite differences in starting MBP, captopril caused similar reductions (38-50%) of MBP and increases in PRA in all groups. Similar results were obtained in two-kidney renal hypertensive rats with hypertension of 12 weeks' duration. It is concluded that the sympathetic nervous system does not contribute to the elevated PRA in two-kidney renal hypertensive rats but does contribute significantly to the development of hypertension in this model.
D000311:Adrenal Glands / Q000503:physiopathology*; D000313:Adrenal Medulla / Q000601:surgery; D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000627:therapeutic use; D003250:Constriction; D006892:Hydroxydopamines / Q000627:therapeutic use; D006977:Hypertension, Renal / Q000209:etiology* / Q000628:therapy; D008297:Male; D051381:Rats; D012077:Renal Artery; D012083:Renin / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D006892:Hydroxydopamines; D000804:Angiotensin II; D002216:Captopril; D012083:Renin