Captopril in mild and severe hypertension.
1. Ten patients with mild essential hypertension and nine with severe treatment-resistant hypertension were treated with captopril. 2. Supine blood lpressure was controlled in 9/10 patients with mild hypertension (four with addition of propranolol). 3. There was no correlation between blood pressure fall and initial plasma renin concentration in patients with mild hypertension. 4. Captopril (plus diuretic and/or propranolol) controlled only 4/9 patients with severe hypertension. 5. Four patients developed reversible dysgeusia and one a skin rash.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011392:Proline / Q000031:analogs & derivatives*; D011433:Propranolol / Q000627:therapeutic use; D012083:Renin / Q000097:blood
D011392:Proline; D002216:Captopril; D011433:Propranolol; D012083:Renin