Long-term treatment of symptomatic osteoarthritis with benoxaprofen. Double-blind comparison with aspirin and ibuprofen.
Benoxaprofen was compared to aspirin or to ibuprofen in 2 28-wk multiclinic double-blind trials in patients with symptomatic osteoarthritis of the knees or hips. The design of the study permitted such comparison even though aspirin and ibuprofen were given in divided doses and benoxaprofen in a single dose. The comparison of benoxaprofen with aspirin included 140 patients and that with ibuprofen 143 patients. All 3 medications caused improvement in every measure of joint disease after 1 wk of therapy and improvement was either increased or maintained for the duration of treatment.
D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use*; D001583:Benzoxazoles / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006621:Hip Joint; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects / Q000627:therapeutic use*; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000187:drug effects; D010003:Osteoarthritis / Q000188:drug therapy*; D010349:Patient Compliance; D011422:Propionates / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D001583:Benzoxazoles; D011422:Propionates; C011677:benoxaprofen; D001241:Aspirin; D007052:Ibuprofen