Effect of parenteral dezocine and placebo in cancer pain.
A double-blind, placebo-controlled crossover trial was carried out in 20 hospitalized patients with continuous pain due to cancer to assess the analgesic effectiveness and tolerance of a single intramuscular injection of 10 mg dezocine. Subjective assessments of pain, made at hourly intervals over 4 hours, showed that dezocine produces a statistically significant greater and sustained relief of pain than did placebo. Only minor side-effects were reported.
D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003516:Cycloparaffins / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000150:complications*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010919:Placebos; D013764:Tetrahydronaphthalenes
D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds; D003516:Cycloparaffins; D010919:Placebos; D013764:Tetrahydronaphthalenes; C010827:dezocine