title: [Angioimmunoblastic lymphadenopathy. Anatomoclinical and immunological study of a case].
abstract: The clinical course of a 54-year-old man with generalized lymphadenopathy bearing all physical, laboratory and histologic characteristics of angioimmunoblastic lymphadenopathy with dysproteinemia is described. Morphologic and laboratory features of a hyperimmune state with autoimmune hemolytic anemia, elevated cold agglutinin levels and polyclonal gammopathy, but with paradoxical cutaneous anergy and decrease in blood T-lymphocytes, were found. Therapy with levamisole was without significant benefit and the patient died 2 months after initial diagnosis. Our findings give further support to the contention that this disease is an abnormal, but non-neoplastic, immune reaction resulting from a loss of suppressor T cells with hyperfunction of the B lymphocyte system.
mesh_terms: D001327:Autoimmune Diseases; D001796:Blood Protein Disorders / Q000150:complications; D003165:Complement System Proteins / Q000032:analysis; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000150:complications / Q000276:immunology / Q000473:pathology*; D007136:Immunoglobulins / Q000032:analysis; D008213:Lymphocyte Activation; D008223:Lymphoma / Q000209:etiology; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000032:analysis
chemical_list: D007136:Immunoglobulins; D003165:Complement System Proteins
vernacular_title: Linfoadenopatia angioimmunoblastica. Studio anatomoclinico ed immunologico di un caso.