title: [Controlled doubleblind study on dose-effect relationship of guanfacine a long-acting hypotensive guanidine derivative (author's transl)].
abstract: N-Amidino-2-(2,6-dichlorophenyl)-acetamide hydrochloride (guanfacine) reduces blood pressure dose-dependently for more than 38 h. The blood pressure lowering effect is not seen immediately after medication. Side effects are: decrease in heart rate, orthostatic effect, dizziness and weariness.
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D016316:Guanfacine; D006146:Guanidines / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008875:Middle Aged; D010648:Phenylacetates / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D011674:Pulse / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents; D006146:Guanidines; D010648:Phenylacetates; D016316:Guanfacine
vernacular_title: Kontrollierte doppelblinde Studie zur Dosis-Wirkungs-Beriehung von Guanfacinum, einem langwirksamen blutdrucksenkenden Guanidin-Derivat.