[Mechanisms of insulin action on antibody-forming cells in vitro].
The influence of different doses of insulin on the quality of plaque forming cells (PFC) has been studied in the spleen cell suspension of immune mouse in vitro, the effect of insulin being dose depending. The quantity of PFC in vitro increased during the incubation with a large dose of insulin and decreased with a small dose. The influence of specific activators and inhibitors of cyclic nucleotides on the effect of insulin has been revealed. It is suggested that insulin may exert its influence on the appearance of PFC through changing the relationships of intracellular cyclic nucleotides.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects*; D006462:Hemolytic Plaque Technique; D007093:Imidazoles / Q000276:immunology; D007114:Immunization; D066298:In Vitro Techniques; D007328:Insulin / Q000276:immunology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012969:Sodium Fluoride / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013806:Theophylline / Q000276:immunology
D007093:Imidazoles; D007328:Insulin; D012969:Sodium Fluoride; D013806:Theophylline
K voprosu o mekhanizmakh deĭstviia insulina na antiteloobrazuiushchie kletki v usloviiakh in vitro.