Requirement for B-lymphocyte alloantigen in the production of neutrophil migration inhibition factor from T lymphocytes (NIF-T).
Neutrophil migration inhibition factor from T lymphocytes (NIF-T) is produced in response to mitogens as the result of cellular interactions between T and B lymphocytes. The requirement for B-cell alloantigen in this interaction process was indicated by (1) collaboration between peripheral blood T cells with various B lymphoblast cell lines but not with non-B lymphoblast cells for NIF-T production, (2) inhibition of NIF-T production by treating collaborating B lymphoblasts with B-cell specific antiserum, and (3) inhibition of NIF-T production by peripheral blood lypmphocytes in the presence of anti-B-cell antiserum and F(ab')2 with anti-B-cell specificity.
D000918:Antibody Specificity; D000961:Antilymphocyte Serum / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D007519:Isoantigens / Q000276:immunology*; D007961:Leukocyte Migration-Inhibitory Factors / Q000096:biosynthesis*; D008211:Lymphocyte Cooperation; D008222:Lymphokines / Q000096:biosynthesis*; D009504:Neutrophils / Q000276:immunology; D013205:Staphylococcal Protein A / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000961:Antilymphocyte Serum; D007140:Immunoglobulin Fab Fragments; D007519:Isoantigens; D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines; D013205:Staphylococcal Protein A