A comparative study of benoxaprofen and ibuprofen in osteoarthritis in general practice.
A total of 120 general practice patients with osteoarthritis of the knee or hip received either benoxaprofen 600 mg mane or ibuprofen 400 mg tid for 4 months in a double-blind, parallel trial. No patients withdrew because of lack of efficacy. Statistically significant differences in favor of benoxaprofen were found for knee flexion and pain relief. A small number of patients withdrew because of gastrointestinal reactions (7 taking benoxaprofen and 6 taking ibuprofen). Skin reactions were commoner with benoxaprofen, which provoked sun sensitivity in 5 patients, none of whom withdrew. Significantly more patients on benoxaprofen (67%) wished to continue therapy than those on ibuprofen (32%).
D000328:Adult; D000367:Age Factors; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001583:Benzoxazoles / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005194:Family Practice; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D011422:Propionates / Q000009:adverse effects / Q000627:therapeutic use*; D012871:Skin Diseases / Q000139:chemically induced; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D001583:Benzoxazoles; D011422:Propionates; C011677:benoxaprofen; D000469:Alkaline Phosphatase; D007052:Ibuprofen