[Mutagenicity of alkylnitrites in the Salmonella test].
It has been shown that five alkylnitrites are mutagens by the Salmonella/microsome assay. n-Propyl-, n-butyl, iso-butyl and amyl-nitrite are direct mutagens on TA 1535; sec-butyl-nitrite is mutagen on TA 1535 only following metabolic activation by Aroclor-induced rat liver homogenate. Because of the known correlation between mutagenicity and carcinogenicity, we believe that amyl-nitrite and iso-butyl-nitrite, which are used as human drugs, should be tested for carcinogenicity in animals; in the meanwhile, their use should be allowed only in emergencies.
D000818:Animals; D001140:Aroclors / Q000494:pharmacology; D001711:Biotransformation; D004305:Dose-Response Relationship, Drug; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D009573:Nitrites / Q000494:pharmacology*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship
D001140:Aroclors; D009153:Mutagens; D009573:Nitrites
Mutagenicita' dei nitriti alchilici nel test della Salmonella.