[Use of a radioimmunological study sequence for elucidating the role of vasopressor factors in the pathogenesis of hypertension].
An increased content of one of the three hormones that were studied (cortisol, aldosterone and renin) or of their various combinations was found in 58 of 97 patients with hypertensive disease. It is concluded that cortisol plays a predominant role in the mechanism of the maintenance of the blood pressure level in the initial stage of the disease and in a milder course of hypertension. In later periods and in cases with higher blood pressure values, its level is sustained by the renin--angiotensin--aldosterone system. The content of the studied hormones was lower in the remaining 39 patients than in the control group.
D000328:Adult; D000450:Aldosterone / Q000097:blood*; D002908:Chronic Disease; D003327:Coronary Disease / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D006973:Hypertension / Q000097:blood / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood*
D000450:Aldosterone; D012083:Renin; D006854:Hydrocortisone
Ispol'zovanie kompleksa radioimmunologicheskikh issledovaniĭ dlia vyiasneniia roli nekotorykh vazopressornykh faktorov v patogeneze gipertonicheskoĭ bolezni.