title: Antibiotic resistance and R-plasmids in food chain Salmonella: evidence of plasmid relatedness.
abstract: A large number of strains (1,783) belonging to 15 Salmonella serovars isolated, in Canada, from the three major links of the human food chain were screened for multiple antibiotic resistance and the presence of R-plasmids. Multiresistant strains occurred among animal feed, livestock, and human isolates at frequencies of 4, 22, and 14%, respectively. Conjugation analysis revealed that 58% of the isolates from feeds, 87% of those from livestock, and 89% of the human strains carried all or part of their resistance determinants extrachromosomally on R-plasmids. Conjugative plasmids representing nine different incompatibility groups were detected, with the Inc I alpha group being predominant. Within the limits of the parameters measured, certain of these plasmids show a degree of relatedness suggestive of a common ancestry.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003227:Conjugation, Genetic; D005516:Food Microbiology; D011815:R Factors; D012475:Salmonella / Q000187:drug effects / Q000235:genetics*; D012486:Salmonella typhimurium / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents