Relationship between HLA-D and in vitro and in vivo responsiveness to Candida allergen.
In vitro reaction to Candida allergen was studied in 100 normal healthy Japanese and related to HLA. A significant association was found between the low responder group (< 7,000 c.p.m.) and HLA-B15 and the high responder group (> 7,000 c.p.m.) and HLA-B7, as well as Dwl. Four HLA-D homozygote cells of types HLA-Dwl and DHO, were tested; these fitted in the high responder group. HLA-DYT and DEn fitted into the low responder group. Responsiveness to Candida allergen corresponded to skin test (r = 0.884, P < 0.01). From these results, in vitro lymphocyte reaction to Candida allergen and skin tests showed close correlation and an association with HLA antigens, HLA-D in particular.
D000328:Adult; D000485:Allergens / Q000276:immunology*; D000946:Antigens, Fungal / Q000276:immunology; D002176:Candida albicans / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D000949:Histocompatibility Antigens Class II; D006801:Humans; D008213:Lymphocyte Activation; D008875:Middle Aged; D012882:Skin Tests
D000485:Allergens; D000946:Antigens, Fungal; D000949:Histocompatibility Antigens Class II