WY 16225 (dezocine), a new synthetic opiate agonist-antagonist and potent analgesic: comparison with morphine for relief of pain after lower abdominal surgery.
Dezocine (Wy 16225), a new analgesic was compared randomly and double-blind with morphine 10 mg in 160 female patients complaining of moderate (group I) or severe (group II) pain after elective lower abdominal surgery; both drugs were given i.m. In group I, pain relief with dezocine 10 and 15 mg was significantly greater than dezocine 5 mg; dezocine 10 mg appeared equipotent with morphine 10 mg. Similar, but statistically insignificant differences were observed in group II. Patient sedation was minimal and untoward side-effects infrequent with all doses of the trial drugs.
D000005:Abdomen / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds / Q000627:therapeutic use*; D002585:Cesarean Section; D002986:Clinical Trials as Topic; D003516:Cycloparaffins / Q000627:therapeutic use*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use*; D010149:Postoperative Pain / Q000188:drug therapy*; D011247:Pregnancy; D013764:Tetrahydronaphthalenes
D000700:Analgesics; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds; D003516:Cycloparaffins; D013764:Tetrahydronaphthalenes; D009020:Morphine; C010827:dezocine