[Mapping of mutations in genes of Flexner shigellae controlling the synthesis of certain ribosomal proteins and study of the effect of these mutations on bacterial virulence].
The study, carried out to localize the mutations which determine resistance to spectinomycin and neamin, has revealed that in Sh. Flexneri the genes of the str -- s area and located in the order similar to the order of their location in E. coli K12: spc A -- nea A -- str A -- nea B. Mutation in spc A gene was shown to have no influence on the capacity of the shigellae for causing keratoconjunctivitis, whereas nea A mutation resulted in the complete loss of virulence; in str A and nea B mutations the complete or partial loss of pathogenic properties was also observed.
D002874:Chromosome Mapping; D004352:Drug Resistance, Microbial; D007637:Keratoconjunctivitis / Q000209:etiology; D009154:Mutation; D009355:Neomycin / Q000494:pharmacology; D012269:Ribosomal Proteins / Q000235:genetics*; D012763:Shigella flexneri / Q000187:drug effects / Q000235:genetics* / Q000472:pathogenicity; D013307:Streptomycin / Q000494:pharmacology; D014774:Virulence
D012269:Ribosomal Proteins; D009355:Neomycin; D013307:Streptomycin
Karitrovanie u shigell Flexnera mutatsiĭ v genakh, kontroliruiushchikh sintez nekotorykh ribosomal'nykh belkov, i izuchenie vliianiia étikh mutatsiĭ na virulentnost' bakteriĭ.