Altered polyvinylpyrrolidone clearance and immune responsiveness caused by small dietary changes.
The introduction of 25 mg of a new protein antigen into the diets of mice produced transient increases in PVP clearance which reached a maximum 60 hr after the change of diet and had disappeared by 4 days. At the same time the immune responsiveness to unrelated antigens given parenterally was also raised transiently, reaching a peak 5 days following the change and disappearing by 7 days. In contrast the responsiveness to the fed antigen was diminished.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology*; D004044:Dietary Proteins; D006462:Hemolytic Plaque Technique; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010047:Ovalbumin / Q000276:immunology; D011205:Povidone / Q000378:metabolism*; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013997:Time Factors
D000941:Antigens; D004044:Dietary Proteins; D010047:Ovalbumin; D011205:Povidone