Phenytoin: biopharmacology.
Among the characteristics of PHT described herein, the following may have some implications in studies of its mechanisms of action: 1. The pKa of PHT may be closer to physiological pH than reported initially. 2. Effective concentrations higher than its solubility at 37 degrees C must involve a binding phenomenon. 3. PHT produces a direct and reversible antieplieptic effect; proposed mechanisms must be compatible with the observed time course of antiepileptic effects. 4. PHT itself is probably solely responsible for its effect. 5. The time course of effect will probably be influenced by dose-dependent kinetics of several species.
D000818:Animals; D001711:Biotransformation; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D007700:Kinetics; D010672:Phenytoin / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D012995:Solubility; D014018:Tissue Distribution
D010672:Phenytoin