title: [A case of chloroquine-resistant (R1) falciparum malaria from the East African Comoros Islands (author's transl)].
abstract: An African from the Comoros Islands, who has been living in Berlin for eleven years and who had made his last journey to Africa two years before, fell ill with high fever upon returning from a visit to Mayotte and Grande Comore. His blood smear revealed trophozoites of Plasmodium falciparum. After intake of 25 mg of chloroquine base per kg body weight within 66 hours, defervescence and clearance of blood ensued and by the fourth day after start of treatment the parasites could no longer be detected in the blood. On the 25th day high fever occurred and P. falciparum was found again. After chloroquine treatment had been repeated with an additional single dose of 75 mg pyrimethamine and 1.5 g sulphadoxine the patient remained healthy. During observation over a period of eight months plasmodia could no longer be detected in thick films.
mesh_terms: D000351:Africa, Eastern; D002738:Chloroquine / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D010963:Plasmodium falciparum / Q000187:drug effects*; D011739:Pyrimethamine / Q000627:therapeutic use; D013413:Sulfadoxine / Q000627:therapeutic use
chemical_list: D013413:Sulfadoxine; D002738:Chloroquine; D011739:Pyrimethamine
vernacular_title: Ein Fall von Falciparum-Malaria mit Chloroquin-Resistenz (R1) von den ostafrikanischen Komoren-Inseln.