[Postreplicative DNA repair in UV-sensitive Chinese hamster cell clones].
The postreplication repair (PRR) of DNA has been studied in UV-irradiated (10 J/m2) and carcinogen (7-bromomethylbenz(alpha)anthracene -- BMBA) treated (1.65-3.3) 10(-6) M Chinese hamster clones with different UV-sensitivity. Ultracentrifugation in alkaline sucrose gradients has been used. Compared to the UV-resistent clone V-79, the UV-sensitive clone CHS2 displayed a lower effectivity of PRR of DNA after both UV-irradiation and carcinogen treatment, by 6 and 10 times, resp. Thus, there is a positive correlation between lethal and mutagenic effects of UV-irradiation and the effectivity of PRR of DNA. The same conclusion is apparently true in the case of carcinogen 7-BMBA treated Chinese hamster cells.
D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology; D002478:Cells, Cultured; D002999:Clone Cells / Q000528:radiation effects*; D006224:Cricetinae; D003412:Cricetulus; D004260:DNA Repair / Q000528:radiation effects*; D004261:DNA Replication; D009154:Mutation; D011836:Radiation Tolerance; D014466:Ultraviolet Rays
D001551:Benz(a)Anthracenes
Postreplikativnaia reparatsiia DNK v UF-chuvstvitel'nykh klonakh kletok kitaĭskogo khomiachka.