title: Effects of furosemide-induced plasma volume reduction on plasma antidiuretic hormone in normal and hypertensive subjects.
abstract: Plasma antidiuretic hormone (ADH) was measured before and after furosemide administration in hypertensive patients (essential benign hypertensions with low plasma renin activity) and in normal subjects. Furosemide-induced reduction of plasma volume was about 10% after 2 hours. In normal subjects, plasma ADH rose progressively till the end of the study (1.5 pg/ml per hour corresponding to about 3 pg/ml per liter of plasma water lost) whereas it remained unchanged in hypertensive patients. There was an early increase of plasma renin activity (PRA) in normal subjects followed by a progressive fall. PRA response was blunted in hypertensive patients. These results show that volume-dependent ADH secretion is inhibited in patients with essential benign hypertension.
mesh_terms: D000328:Adult; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010953:Plasma Volume / Q000187:drug effects*; D012083:Renin / Q000097:blood; D014667:Vasopressins / Q000097:blood*
chemical_list: D014667:Vasopressins; D005665:Furosemide; D012083:Renin