[Evaluation of nephropathies in children with rheumatoid arthritis and prolonged therapy with salicylates].
The study included 18 school-age and adolescent patients with juvenile rheumatoid arthritis who had consumed from 351 to 6393 gm. (average 2813 gm.) as total dose for the control of their disease. All of them underwent a complete physical examination, general laboratory tests and as specific tests of renal function; urinalysis, urine culture, endogenous creatinine clearance, Addis count (red and white cells), sodium and potassium urinary excretion, urinary acidity capacity, administration of ammonium chloride and capacity of urinary concentration following water restriction. Normal results in practically all parameters led to conclude that a clear evidence of nephropathy due to salicylic acid consumption, was not found in any of the patients studied.
D000293:Adolescent; D000328:Adult; D001171:Arthritis, Juvenile / Q000188:drug therapy*; D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000175:diagnosis*; D007677:Kidney Function Tests; D008297:Male; D010919:Placebos
D010919:Placebos; D001241:Aspirin
Valoración de nefropatía en niños con artritis reumatoide y terapia prolongada con salicilatos.