Gastric marker proteins. Purification and immunohistological demonstration of the chief cell esterase.
An immunogenic acid stable esterase of gastric origin was purified from normal gastric juice. Specific antibodies were obtained by solid immunoadsorbents and were used for indirect immunoenzyme histology on gastric resection specimens. This esterase proved to be a cell specific marker for gastric chief cells. Different patterns of chief cell alterations in gastritis and cancer were observed.
D004950:Esterases / Q000032:analysis* / Q000276:immunology; D005750:Gastric Juice / Q000201:enzymology*; D005753:Gastric Mucosa / Q000201:enzymology*; D005756:Gastritis / Q000201:enzymology; D006801:Humans; D007124:Immunoenzyme Techniques; D013274:Stomach Neoplasms / Q000201:enzymology
D004950:Esterases