Determination, source, metabolism, and functional role of renal prostaglandins.
A brief review of prostaglandin (PG) bio-chemistry of the kidney is presented. Methods of assessing renal PG synthesis are discussed and pitfalls pointed out. A role of renal PGs in renin release and water metabolism of man is shown. Experiments are described which form the basis for a hypothesis which postulates a role for renal cortical prostacyclin in renin release.
D000818:Animals; D001834:Body Water / Q000378:metabolism; D004285:Dogs; D011464:Epoprostenol / Q000378:metabolism; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007668:Kidney / Q000032:analysis; D007672:Kidney Cortex / Q000378:metabolism*; D007679:Kidney Medulla / Q000378:metabolism*; D011453:Prostaglandins / Q000032:analysis / Q000096:biosynthesis / Q000378:metabolism* / Q000502:physiology; D011458:Prostaglandins E / Q000378:metabolism; D011817:Rabbits; D012083:Renin / Q000378:metabolism; D014667:Vasopressins / Q000378:metabolism
D011453:Prostaglandins; D011458:Prostaglandins E; D014667:Vasopressins; D011464:Epoprostenol; D012083:Renin