Leukocyte kinetics, cell cycle and leukemic proliferation.
A review is presented of the available data in the medical literature and of the author's experience in the study of leukocyte kinetics, starting with the originary stem cell. To facilitate understanding of the process of leukocyte proliferation in leukemias, theoretical and methodological details are given on the techniques for determination of the cell cycle and its perturbations during evolution of the various types of leukemias. Some data on animal leukemias are also discussed. A critical analysis is made of the action of immunosuppressive cytostatic drugs on the leukemic cell proliferation.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001854:Bone Marrow Cells; D002453:Cell Cycle; D002478:Cells, Cultured; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006413:Hematopoietic System / Q000473:pathology; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D007939:Leukemia L1210 / Q000473:pathology*; D007962:Leukocytes / Q000166:cytology*; D007964:Leukocytosis; D008938:Mitosis / Q000187:drug effects*
D000970:Antineoplastic Agents