Adenylate cyclase activity in human liver membranes correlated to insulin release and glucose tolerance.
Glucagon-stimulated adenylate cyclase activity has been studied in human crude liver membranes prepared from liver biopsies taken at cholecystectomies. Enzyme activities were negatively correlated to 0-40 min plasma insulin increments determined preoperatively by oral glucose tolerance tests.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D002462:Cell Membrane / Q000201:enzymology; D005934:Glucagon / Q000494:pharmacology; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon; D000262:Adenylyl Cyclases