The effect of alcohol on dopamine metabolism in the caudate nucleus of an unanesthetized monkey.
Previously it was shown that the acute administration of ethanol to the rat significantly alters the metabolism of the dopamine (DA) in liver but not in brain tissue. To extend this finding to the primate, two push-pull perfusion cannulae were implanted in the regions of the left and right caudate nucleus of a Macaca nemistrina. After 14C-DA was injected into the caudate, the site ws perfused with an artificial CSF and the perfusate analyzed for the major metalolites of DA. Ethanol was then administered in a dose of 6 g/kg by the nasopharyngeal route. The results show that very little alteration occurs in the metabolism of DA during or postethanol intoxication.
D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D008254:Macaca nemestrina; D008297:Male
D000431:Ethanol; D004298:Dopamine