Evolution of ideas on the role of prostaglandins in inflammation.
Anti-inflammatory activity is found among compounds which in vitro inhibit (aspirin), stimulate (chlorpromazine) or have no effect on (hydrocortisone) biosynthesis of primary prostaglandins. On the other hand some in vitro stimulators of prostaglandin biosynthesis (e.g. pyrazol(3,4b)-pyridine derivatives) are pro-inflammatory agents. It is concluded that primary prostaglandins do not play a pivotal role in inflammatory response.
D000082:Acetaminophen / Q000494:pharmacology; D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism / Q000494:pharmacology; D005075:Biological Evolution; D002084:Butylated Hydroxytoluene / Q000031:analogs & derivatives / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D049673:History, 20th Century; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D015289:Leukotrienes; D008054:Lipid Peroxides; D010545:Peroxides / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis / Q000266:history* / Q000502:physiology; D011457:Prostaglandins D / Q000266:history / Q000378:metabolism; D011458:Prostaglandins E / Q000266:history / Q000378:metabolism; D011460:Prostaglandins F / Q000266:history / Q000378:metabolism; D011462:Prostaglandins G; D051381:Rats; D012756:Sheep
D001095:Arachidonic Acids; D015289:Leukotrienes; D008054:Lipid Peroxides; D010545:Peroxides; D011453:Prostaglandins; D011457:Prostaglandins D; D011458:Prostaglandins E; D011460:Prostaglandins F; D011462:Prostaglandins G; D002084:Butylated Hydroxytoluene; D000082:Acetaminophen; C013753:2-aminomethyl-4-t-butyl-6-iodophenol; C025086:15-hydroperoxy-5,8,11,13-eicosatetraenoic acid; D002746:Chlorpromazine