Brain tissue from persons dying of Creutzfeldt-Jakob disease causes scrapie-like encephalopathy in goats.
Two goats became affected with an encephalopathy indistinguishable from scrapie 43 months after they were inoculated intracerebrally with 10% suspensions of brain from two persons dying of Creutzfeldt-Jakob disease. Although this observation does not establish the common identity of Creutzfeldt-Jakob disease virus and scrapie virus, it is thought to provide strong evidence of a close etiological relationship between the two diseases.
D000368:Aged; D000818:Animals; D001921:Brain / Q000382:microbiology / Q000473:pathology*; D001927:Brain Diseases / Q000473:pathology / Q000635:transmission / Q000662:veterinary*; D007562:Creutzfeldt-Jakob Syndrome / Q000209:etiology / Q000473:pathology / Q000635:transmission*; D005260:Female; D006041:Goats; D006801:Humans; D008297:Male; D008875:Middle Aged; D012608:Scrapie / Q000209:etiology*; D012756:Sheep