N-Methyl-D-aspartate acid: a convulsant with weak neurotoxic properties.
N-Methyl-D-aspartic acid (NMDA) is 100-fold less potent as a neurotoxin than kainic acid when injected into the rat striatum. However, NMDA, when injected into the hippocampus, causes a more severe seizure disorder than kainic acid and doses of NMDA than produce much smaller lesions than those caused by kainate. These results indicate a poor correlation between convulsant and neurotoxic properties of acidic excitatory amino acids.
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D003292:Convulsants; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D007608:Kainic Acid / Q000494:pharmacology; D016202:N-Methylaspartate; D009498:Neurotoxins; D051381:Rats
D003292:Convulsants; D009498:Neurotoxins; D001224:Aspartic Acid; D016202:N-Methylaspartate; D007608:Kainic Acid