Colloid or crystalloid in the resuscitation of hemorrhagic shock: a controlled clinical trial.
The object of this article is to assess the value of human serum albumin (HSA) in the initial resuscitation of hypotensive trauma victims. Thirty-six patients (mean age = 30 years) in shock from trauma who underwent laparotomies were randomly assigned to either Ringer's lactate solution (RL) resuscitation or 4% HSA in RL resuscitation. Both groups received approximately 8L of test fluid and 6U of washed red cells. The only death in the study occurred in a patient assigned to the RL group. Two patients in each group required mechanical ventilation for longer than 24 hours. No differences were noted in a battery of pulmonary function tests performed daily for 5 days. These results demonstrate that HSA is not essential in this clinical setting for safe and effective resuscitation.
D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007552:Isotonic Solutions / Q000008:administration & dosage*; D007813:Laparotomy; D008297:Male; D012121:Respiration, Artificial; D012129:Respiratory Function Tests; D012151:Resuscitation; D000077325:Ringer's Lactate; D012709:Serum Albumin / Q000008:administration & dosage*; D012771:Shock, Hemorrhagic / Q000097:blood / Q000628:therapy*; D012774:Shock, Traumatic / Q000097:blood / Q000601:surgery
D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D012709:Serum Albumin