The effect of naftidrofuryl (Praxilene) on intermittent claudication.
In a randomized double-blind controlled trial the effect of naftidrofuryl (Praxilene) 200 mg t.d.s., taken for 6 months, was compared with placebo in intermittent claudication. Whilst there was a significant subjective improvement regardless of age or treatment, patients over 60 on naftidrofuryl experienced a more rapid symptomatic relief than other patients. At six months this age group showed a significant improvement over the placebo group. There was no significnat objective evidence of improvement.
D000368:Aged; D000842:Ankle; D001794:Blood Pressure; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005663:Furans / Q000627:therapeutic use*; D006801:Humans; D007383:Intermittent Claudication / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009257:Nafronyl / Q000627:therapeutic use*; D005082:Physical Exertion; D010919:Placebos; D011897:Random Allocation
D005663:Furans; D010919:Placebos; D009257:Nafronyl