title: Blood transfusion-induced facilitation of kidney graft survival in rats (congenic-resistant strains).
abstract: The correlation between the degree of histoincompatibility and kidney graft survival after active sensitization by blood transfusions has been investigated in congenic resistant strains of rats with MHC (H-1)-restricted incompatibility as compared to standard strains. It has been found that the beneficial effect of transfusions for graft survival becomes most evident when compatibility for the so-called minor non-H-1-antigens exists. H-1-congenic rats with MHC differences alone show indefinite graft survival irrespective of the interallelic combination. Donor-specific sensitization is the treatment of choice. Third-party blood is by far inferior. H-1-identical, but non-H-1-different blood, with respect to the recipient strain genotype, is ineffective in the facilitation of H-1-different grafts. The facilitation effect does not increase with the number of blood injections. As early as 1 week after blood treatment, there is permanent survival of grafted kidneys, but there is a definite loss of graft-protecting factors with time.
mesh_terms: D000818:Animals; D001803:Blood Transfusion; D006082:Graft Enhancement, Immunologic / Q000379:methods*; D006084:Graft Rejection; D006085:Graft Survival; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation; D008285:Major Histocompatibility Complex; D051381:Rats; D011919:Rats, Inbred Strains; D014184:Transplantation, Homologous