The immunosuppressive effect of concanvalin A. III. Influence on the survival time of skin allografts in mice.
The influence of Con-A on the survival time of skin grafts in mice was examined. F1 mice (BALB/c X DBA/2) were the skin donors and C57BL X C3H were the recipients. More than a two-fold prolongation in the survival time of the grafted skin was obtained by a single 100 microgram dose of Con-A given intravenously to mice 24 h prior to grafting. Con-A given in a similar manner three days after grafting did not influence the skin graft. The results obtained substantiate our earlier observations which suggested that Con-A administered prior to an antigen may inhibit the immunological response.
D000818:Animals; D003208:Concanavalin A / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D006085:Graft Survival / Q000187:drug effects*; D007166:Immunosuppressive Agents; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D011182:Postoperative Care; D011300:Preoperative Care; D016038:Skin Transplantation; D013997:Time Factors; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D003208:Concanavalin A