Regression on oxymetholone-induced hepatic tumors after bone marrow transplantation in aplastic anemia.
Treatment of acquired aplastic anemia with androgens has been occasionally associated with the development of hepatic tumors. We have studied a 13-year-old boy with idiopathic aplastic anemia in whom oxymetholone treatment was associated with a partial hematological remission. Thirty-four months later, however, the patient developed multiple hepatic tumors. When oxymetholone therapy was discontinued, the aplastic anemia relapsed. He then underwent bone marrow transplantation from his HLA-A, B, and D-compatible sibling. This was followed by hematological and immunological reconstitution. The hepatic tumors underwent progressive regression after bone marrow transplantation. The patient is now 3 years post-bone marrow transplantation and is in complete remission of his aplastic anemia with no evidence of detectable liver tumors.
D000293:Adolescent; D000741:Anemia, Aplastic / Q000150:complications* / Q000188:drug therapy; D016026:Bone Marrow Transplantation; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D010110:Oxymetholone / Q000009:adverse effects*; D014184:Transplantation, Homologous; D014463:Ultrasonography
D010110:Oxymetholone