[Measurement of insulin sensitivity in obese or diabetic children in vivo. A comparison of three methods (author's transl)].
Three groups of ten similar obese children were infused with one of three protocols. Protocol I glucose only (1.15 mM/min/m2). protocol II, glucose, insulin (42 mM/min/m2). Protocol III, glucose insulin, propanolol (0.04 mg/min/m2) adrenalin (3 micrograms/min/m2). Eighteen newly diagnosed diabetic children without acidosis received glucose according to protocol II. Thirteen normal adults (controls) received glucose infusion according to protocol I. Protocols I and II were well tolerated and gave consistent results but Protocol III was not well tolerated and did not give interpretable results. In obese children steady state blood glucose levels are significantly higher than in controls but this difference was only moderate (8.8 + 0.7 mM, against 6.6 +/- 0.4 mM for protocol I). There was no difference in insulin levels. In diabetic children the steady state was more rarely obtained after a 120 min infusion and blood glucose levels were higher than in the controls or in obese children.
D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood; D002648:Child; D003920:Diabetes Mellitus / Q000503:physiopathology*; D004837:Epinephrine; D005947:Glucose; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D009765:Obesity / Q000503:physiopathology*; D011433:Propranolol
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D011433:Propranolol; D005947:Glucose; D004837:Epinephrine
Mesure de la sensibilité à l'insuline in vivo chez l'enfant obèse, ou diabétique. Comparaison entre trois méthodes.