Influence of D,L-ureidosuccinic acid dihydrazide on some biological properties of Pseudomonas pseudomallei and of Salmonella typhimurium.
The changes induced in strains of Pseudomonas pseudomallei and Salmonella typhimurium under the action of D.L-ureidosuccinic acid dihydrazide were characterized. A decrease of the speed of multiplication in vitro and of the oxygen consumption was established. The virulence of the strains was reduced and their susceptibility to phagocytosis in vitro was increased.
D000963:Antimetabolites / Q000494:pharmacology*; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011549:Pseudomonas / Q000187:drug effects* / Q000472:pathogenicity / Q000502:physiology; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000472:pathogenicity / Q000502:physiology; D014774:Virulence
D000963:Antimetabolites; D001224:Aspartic Acid; C027192:ureidosuccinic acid dihydrazide