Inhibition of sterol biosynthesis in Candida albicans by imidazole-containing antifungals.
A simple procedure for studying sterol biosynthesis in cell-free homogenates of Candida albicans is described. The activities of some imidazole-containing antifungals (tioconazole, clotrimazole, econazole, ketoconazole and miconazole) as inhibitors of sterol C-14 demethylation have been determined using this technique.
D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000378:metabolism*; D007093:Imidazoles / Q000494:pharmacology*; D008722:Methods; D008825:Miconazole / Q000494:pharmacology; D013261:Sterols / Q000096:biosynthesis*
D000935:Antifungal Agents; D007093:Imidazoles; D013261:Sterols; D008825:Miconazole