Retinoids, cancer, and the skin.
Vitamin A and its newly developed synthetic analogues recently have been demonstrated to have profound effects on disorders of keratinization, sebaceous gland function, and cancer. In separate sections of this article, we review the history, chemistry, metabolism, mechanism of action, toxicity, and clinical applications of both the naturally occurring and synthetic retinoids.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002352:Carrier Proteins / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003600:Cytosol / Q000378:metabolism; D006801:Humans; D009748:Nutrition Disorders / Q000175:diagnosis; D012098:Reproduction / Q000187:drug effects; D012177:Retinol-Binding Proteins / Q000378:metabolism; D012867:Skin / Q000187:drug effects*; D012871:Skin Diseases / Q000175:diagnosis / Q000188:drug therapy; D014212:Tretinoin / Q000378:metabolism; D014785:Vision, Ocular / Q000187:drug effects; D014801:Vitamin A / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology
D000970:Antineoplastic Agents; D002352:Carrier Proteins; D012177:Retinol-Binding Proteins; D014801:Vitamin A; D014212:Tretinoin