Characterization of facteur thymique sérique (FTS) in the thymus. II. Direct demonstration of the presence of FTS in thymosin fraction V.
Thymosin fraction V was submitted to the same purification procedure as used for the isolation of the circulating thymic factor (FTS) from pig serum: an FTS-like material was isolated from this fraction and shown to have similar activity, molecular weight, charge and amino acid composition as FTS. These data, together with previous experiments showing the binding of anti-FTS antibodies to reticulo-epithelial cells, provide a direct argument in favour of the presence of FTS in the thymus.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002852:Chromatography, Ion Exchange; D007163:Immunosorbent Techniques; D051379:Mice; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D013935:Thymic Factor, Circulating / Q000302:isolation & purification*; D013947:Thymosin / Q000302:isolation & purification; D013950:Thymus Gland / Q000032:analysis*; D013951:Thymus Hormones / Q000302:isolation & purification*
D000596:Amino Acids; D013951:Thymus Hormones; D013947:Thymosin; D013935:Thymic Factor, Circulating