[Study of pulmonary lymphocyte populations obtained by alveolar lavage].
Purified alveolar lymphocytes obtained by bronchial lavage have been studied in 66 subjects: 8 normals, 24 sarcoidosis, 8 tuberculosis, 4 hypersensitivity pneumonitis, 6 collagen diseases and 16 miscellaneous. The following T and B lymphocyte markers have been used: E and EAC Rosettes, Surface membrane immunoglobulins, la antigen and human T lymphocyte antigens. The PHA or ConA responses of some blood and alveolar lymphocyte cultures have also been compared. The results emphasize: -- the tight correlation between the different marker techniques to T and B lymphocytes; -- the larger increases of T lymphocytes in active vs inactive sarcoidosis (p less than 0.001); -- the difference in T lymphocyte number in active vs inactive tuberculosis and in treated vs untreated miliary tuberculosis; -- the absence of alveolar lymphocyte increase in collagen diseases.
D000328:Adult; D000542:Alveolitis, Extrinsic Allergic / Q000503:physiopathology; D001980:Bronchi; D003095:Collagen Diseases / Q000503:physiopathology; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008214:Lymphocytes / Q000502:physiology*; D008297:Male; D008934:Mitogens / Q000494:pharmacology; D011650:Pulmonary Alveoli / Q000166:cytology*; D012397:Rosette Formation; D012507:Sarcoidosis / Q000503:physiopathology; D007507:Therapeutic Irrigation; D014397:Tuberculosis, Pulmonary / Q000503:physiopathology
D008934:Mitogens
Etude des populations lymphocytaires pulmonaires recueillies par lavage alvéolaire.