title: Continued chemical and physiological studies with antigonadotropic fractions from extracts of bovine pineal glands.
abstract: A variety of experiments carried out in recent years are reviewed and evidence is presented for the presence of non-indolic, pineal antigonadotropic substances in pineal extracts and partially purified pineal fractions. Other data are presented suggesting the presence of prolactin releasing and release-inhibiting substances in bovine pineal glands. Also, the sulfur-containing amino acid and putative neurotransmitter taurine was found in large quantities in bovine pineals closely associated with fractions possessing antigonadotropic activity.
mesh_terms: D000818:Animals; D001681:Biological Assay; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D051379:Mice; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D010870:Pineal Gland / Q000502:physiology*; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism
chemical_list: D010455:Peptides; C019407:antigonadotropin, pineal; D007987:Gonadotropin-Releasing Hormone; D011388:Prolactin