title: Biotin regulatory (bir) mutations of Escherichia coli.
abstract: Most mutants selected for derepression of the biotin operon required elevated concentrations of biotin for growth. Mutant extracts were deficient in holoenzyme synthetase activity.
mesh_terms: D001059:Apoproteins / Q000378:metabolism; D001710:Biotin / Q000096:biosynthesis* / Q000378:metabolism / Q000494:pharmacology; D019731:Carbon-Nitrogen Ligases; D004926:Escherichia coli / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D005809:Genes, Regulator; D008025:Ligases / Q000378:metabolism; D009154:Mutation; D012097:Repressor Proteins / Q000096:biosynthesis
chemical_list: D001059:Apoproteins; D012097:Repressor Proteins; D001710:Biotin; D008025:Ligases; D019731:Carbon-Nitrogen Ligases; C023312:holocarboxylase synthetases