Biologic activities of biosynthetic human insulin in healthy volunteers and insulin-dependent diabetic patients monitored by the artificial endocrine pancreas.
This study investigates and compares biosynthetic human insulin (BHI) and purified pork insulin, in healthy volunteers and in insulin-dependent diabetic patients, in terms of biologic action, capacity for controlling diabetic patients, and the requirements of the patients on each insulin. The possible importance of this new insulin in the improved long-term control of diabetic patients led to the experimental design of this protocol.
D000328:Adult; D000818:Animals; D001187:Artificial Organs; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D005755:Gastrins / Q000097:blood; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000096:biosynthesis / Q000627:therapeutic use; D007515:Islets of Langerhans / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D013552:Swine
D001786:Blood Glucose; D002096:C-Peptide; D005755:Gastrins; D007328:Insulin; D013006:Growth Hormone; D006854:Hydrocortisone