Localisation of 125I-labelled streptolysin O of Streptococcus pyogenes in mice.
The fate of 125I-labelled Streptolysin O injected intravenously into mice was studied. After 2 hours only 5% of the injected label remained in the blood. The highest concentration of radioactivity was consistently observed in the liver and kidneys. The labelled toxin was degraded in the liver but its greatest toxic effect took place in the kidneys.
D000818:Animals; D001345:Autoradiography; D001426:Bacterial Proteins; D007457:Iodine Radioisotopes; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D013297:Streptococcus pyogenes / Q000032:analysis*; D013301:Streptolysins / Q000378:metabolism* / Q000633:toxicity; D014018:Tissue Distribution
D001426:Bacterial Proteins; D007457:Iodine Radioisotopes; D013301:Streptolysins; C025964:streptolysin O