title: [Tranquilizing activity of adamantane derivatives].
abstract: It was established in experiments on mice and rats carried out according to conventional procedures that 13 adamantane derivatives have a greater tranquilizing activity than amantadine, 3-bromadamantoyl-1 diazomethane exerting a stronger effect than trioxazin. Two adamantane derivatives were found to have an anticonvulsant activity.
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000633:toxicity; D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects; D004924:Escape Reaction / Q000187:drug effects; D005260:Female; D006801:Humans; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009126:Muscle Relaxation / Q000187:drug effects; D009949:Orientation / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D051381:Rats; D012890:Sleep / Q000187:drug effects; D014149:Tranquilizing Agents
chemical_list: D014149:Tranquilizing Agents; D000218:Adamantane; D010433:Pentylenetetrazole
vernacular_title: Trankviliziruiushchaia aktivnost' proizvodnykh adamantana.