Effects of sodium DL-lactate on insulin secretion in anesthetized dogs.
The effect of sodium DL-lactate administration on insulin release in anesthetized dogs has been studied. Eleven mongrel dogs were infused with sodium DL-lactate for 20 min at the rate of 20 mg/kg . min. Lactate infusion produced simultaneous increases in blood glucose and plasma insulin levels in the pancreaticoduodenal vein. To determine whether lactate stimulated insulin secretion directly, sodium DL-lactate was rapidly injected into the pancreatic artery of six dogs; this pulse induced a significant increase in insulin release from pancreatic B-cells, even in the absence of a measurable change in blood glucose. Diazoxide, when infused in six dogs, blocked lactate-induced insulin secretion. These findings indicate that lactate, as do other circulating energy fuels, may play a role in the physiologic control of insulin secretion.
D000818:Animals; D001786:Blood Glucose; D003981:Diazoxide / Q000008:administration & dosage; D004285:Dogs; D005215:Fasting; D005947:Glucose; D007263:Infusions, Parenteral; D007269:Injections, Intra-Arterial; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007773:Lactates / Q000097:blood / Q000494:pharmacology*; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D013268:Stimulation, Chemical
D001786:Blood Glucose; D007328:Insulin; D007773:Lactates; D005947:Glucose; D003981:Diazoxide