Immunohistochemical study of the LHRH-synthesizing neuron system of aged female rats.
The LHRH-synthesizing neuron system was studied in young proestrous and old female rats, and in aged ovariectomized or reserpine-treated females. The medial preoptic area and septal region of old animals contains more LHRH positive perikarya compared to that of young proestrous rats. Reserpine treatment moderately increases the number of immunostainable LHRH cells, while ovariectomy is ineffective in this respect.
D000375:Aging; D000818:Animals; D001369:Axons / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002369:Castration; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D008473:Median Eminence / Q000378:metabolism; D011247:Pregnancy; D011359:Proestrus; D051381:Rats; D012110:Reserpine / Q000494:pharmacology
D007987:Gonadotropin-Releasing Hormone; D012110:Reserpine