Prognostic significance of B and T cell antibodies in kidney transplantation.
The prognostic significance of pre- and post-transplant B and T cell antibodies was studied in 183 cadaver kidney transplantations. Our results confirm previous reports that a successful kidney transplantation can be carried out in spite of a positive crossmatch due to B cell antibodies. However, it is doubtful whether such antibodies have a protective effect. The success rate seemed to be higher only in patients with preformed cold antibodies. The occurrence and persistence of allogeneic anti-donor antibodies directed against T cells was significantly associated with an unfavourable graft prognosis. Patients with post-transplant anti-donor B cell antibodies had lower (but not significantly) graft survival rates. These findings provide additional evidence for a crucial role of anti-donor antibodies in kidney graft outcome.
D000906:Antibodies / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D011379:Prognosis; D013601:T-Lymphocytes / Q000276:immunology*; D013696:Temperature; D013997:Time Factors; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D000906:Antibodies