10-Hydroxy-3,4-dihydroacridine-1,9(2H,10H)-diones, a new group of malaricidal and coccidiostatic compounds.
2-Nitrobenzaldehydes and 1,3-cyclohexanediones condense in a mixture of hydrochloric acid and glacial acetic acid to 10-hydroxy-3,4-dihydroacridine-1,9(2H,10H)-diones. Many compounds of this group reveal a pronounced coccidiostatic and malaricidal effect in vivo even against drug-resistant malaria parasites. Synthesis and chemotherapeutic results as well as structure-activity relationships are described.
D000166:Acridines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D002645:Chickens; D003049:Coccidiostats / Q000138:chemical synthesis*; D004353:Drug Evaluation, Preclinical; D004539:Eimeria / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D010962:Plasmodium berghei / Q000187:drug effects; D013329:Structure-Activity Relationship
D000166:Acridines; D000962:Antimalarials; D003049:Coccidiostats