Prolactin and the regulation of adipose-tissue metabolism during lactation in rats.
Removal of litters from young lactating rats for 24 or 48 h or treatment of lactating rats with bromocriptine increased the rate of fatty acid synthesis and the activities of lipoprotein lipase and fatty acid synthetase in adipose tissue, decreased the lipoprotein lipase and fatty acid synthetase activities of mammary gland and lowered the serum-prolactin concentration. Concurrent injections of prolactin prevented the effects of bromocriptine and 24 h of litter removal on most of these changes in adipose tissue, but did not prevent the effects of 48 h of litter removal. The results suggest that effects of prolactin on adipose-tissue metabolism are dependent on a functional mammary gland. Most of the responses of adipose tissue to litter removal were reduced in older rats.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D064429:Fatty Acid Synthases / Q000378:metabolism; D005227:Fatty Acids / Q000096:biosynthesis; D005260:Female; D007328:Insulin / Q000097:blood; D007774:Lactation; D008071:Lipoprotein Lipase / Q000378:metabolism; D011247:Pregnancy; D011388:Prolactin / Q000097:blood / Q000494:pharmacology*; D051381:Rats; D011972:Receptor, Insulin / Q000378:metabolism
D005227:Fatty Acids; D007328:Insulin; D001971:Bromocriptine; D011388:Prolactin; D064429:Fatty Acid Synthases; D011972:Receptor, Insulin; D008071:Lipoprotein Lipase