Transfusion problems associated with transplantation.
We have reviewed the role of blood transfusions in renal and marrow graft recipients. Striking contrasts are evident: while transfusions may promote successful kidney grafting, any transfusions before initiation of the transplant conditioning regimen may jeopardize the treatment of severe aplastic anemia by marrow transplantation. We have suggested guidelines for the transfusion support of transplant candidates before transplantation and for marrow graft recipients after transplantation. It is important to recognize that after conditioning for marrow transplantation, all patients will be profoundly pancytopenic for a limited period of time, and intensive transfusion support is vital to patient survival.
D000208:Acute Disease; D000741:Anemia, Aplastic / Q000628:therapy; D000818:Animals; D001787:Blood Group Incompatibility / Q000276:immunology; D016026:Bone Marrow Transplantation; D004285:Dogs; D017707:Erythrocyte Transfusion; D004912:Erythrocytes / Q000528:radiation effects; D006084:Graft Rejection; D006085:Graft Survival; D006098:Granulocytes / Q000637:transplantation; D006680:HLA Antigens; D006801:Humans; D007114:Immunization; D016030:Kidney Transplantation; D007938:Leukemia / Q000628:therapy; D008253:Macaca mulatta; D051379:Mice; D017713:Platelet Transfusion; D012709:Serum Albumin / Q000008:administration & dosage; D065227:Transfusion Reaction
D006680:HLA Antigens; D012709:Serum Albumin