Effects of four prostaglandin analogues on menstrual cycle length and peripheral levels of 17 beta-oestradiol and progesterone in the chacma baboon.
Four different prostaglandin analogues were studied with regard to their effects on menstrual cycle length and peripheral in th chacma baboon (Papio ursinus). Pooled data showed that the luteal phase was shortened by more than 4 days and that both hormone levels were reduced significantly after treatment. In terms of the inhibition of progesterone production as an absolute index of corpus luteum function, PGF2 alpha, 1,15-lactone, and 11 alpha (15S)-17-phenyl-ent-18-19,20-trinor-PGE2 methyl ester were found to be the most effective luteolytic compounds.
D000818:Animals; D002986:Clinical Trials as Topic; D004958:Estradiol / Q000097:blood*; D005260:Female; D008183:Luteal Phase / Q000187:drug effects; D008598:Menstruation / Q000187:drug effects*; D010215:Papio / Q000502:physiology*; D011374:Progesterone / Q000097:blood*; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*
D011461:Prostaglandins F, Synthetic; D011374:Progesterone; D004958:Estradiol