title: Aplastic anemia: recent advances in pathogenesis and treatment.
abstract: Successful bone marrow transplantation and bone marrow culturing techniques have generated a large body of research into the pathogenesis and treatment of aplastic anemia. Most prominent has been the emphasis on autoimmune mechanisms. Several etiologic types and diagnostic criteria are discussed, the evidence supporting immune and other mechanisms of pathogenesis is examined, and results of current therapeutic trials are addressed.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000728:Androgens / Q000627:therapeutic use; D000741:Anemia, Aplastic / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D000818:Animals; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001803:Blood Transfusion; D016026:Bone Marrow Transplantation; D002454:Cell Differentiation; D003602:Cytotoxicity, Immunologic; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D051379:Mice; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000305:Adrenal Cortex Hormones; D000728:Androgens; D000961:Antilymphocyte Serum; D008094:Lithium