[Causes of insulin secretion disorders in non-insulin dependent diabetics. Comparison of in vivo results with examinations of isolated islet cells].
Non-insulin dependent diabetics (NIDD) used in our experiments do not or in a small extend only respond to glucose; but glucagon and tolbutamide loads result in an increased insulin secretion. In contrast, pancreatic islets isolated from biopsies of the pancreas do not show any differences in insulin secretion, biosynthesis and content between NIDD and control groups. Some reasons of these differences between in vivo and in vitro results are discussed.
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000503:physiopathology*; D005260:Female; D005934:Glucagon / Q000097:blood; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012636:Secretory Rate; D014044:Tolbutamide / Q000627:therapeutic use
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon; D014044:Tolbutamide
Ursachen der Insulinsekretionsstörung bei nichtinsulinabhängigen Diabetikern. Vergleich von In-vivo-Befunden mit Untersuchungen an isolierten Langerhansschen Inseln.