An ambulatory trial of guanfacine.
1. The effects of acute and long-term treatment with guanfacine on ambulatory BP were studied. 2. The first day of therapy with guanfacine 1 mg produced a small reduction in BP whereas chronic therapy with doses up to 6 mg given once daily produced a substantial smooth reduction throughout the whole 24 hours. 3. There were no noticeable symptoms or rebound effects on withdrawal of the drug; side-effects, were, however, prominent during therapy. 4. The drug reduced BP during dynamic exercise but did little during isometric exercise; no postural hypotension was noted during tilting.
D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D002940:Circadian Rhythm / Q000187:drug effects; D002986:Clinical Trials as Topic; D005260:Female; D016316:Guanfacine; D006146:Guanidines / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007537:Isometric Contraction; D008297:Male; D008875:Middle Aged; D010648:Phenylacetates / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D005082:Physical Exertion; D011187:Posture; D013312:Stress, Physiological / Q000503:physiopathology; D013997:Time Factors
D000959:Antihypertensive Agents; D006146:Guanidines; D010648:Phenylacetates; D016316:Guanfacine