[Indirect immunofluorescence and complement absorption test characterization of anti-brain antibodies in schizophrenia].
The content and tropism of anticerebral antibodies were examined in 20 schizophrenic patients using the indirect immunofluorescence and complement fixation tests. With the aid of the latter the antibodies were revealed in 15 patients, the antibodies to the homologous brain being more frequent in patients with a more severe, continuously progressing schizophrenia, while the antibodies to a heterologous (rat) brain were more often detected in patients with slowly progressing forms of the disease. In 18 patients, the indirect immunofluorescence test showed fixation of immunoglobulins on the nervous tissue components, such as, neurons, myelin, vascular walls. Rather frequently fluorescence of the microglia cells was observed: according to literary data this is not the case with sera of neurological patients. Of attention was a selective fluorescence of the canaliculi observed in examinations of the renal tissue. The data obtained point to a participation of the immunological reactions in the schizophrenia pathogenesis, these reactions involving various morphological and functional systems.
D000328:Adult; D000818:Animals; D001323:Autoantibodies / Q000032:analysis*; D001808:Blood Vessels / Q000276:immunology; D001921:Brain / Q000276:immunology*; D003168:Complement Fixation Tests; D005455:Fluorescent Antibody Technique; D006801:Humans; D007668:Kidney / Q000276:immunology; D009457:Neuroglia / Q000276:immunology; D009474:Neurons / Q000276:immunology; D009928:Organ Specificity; D051381:Rats; D012559:Schizophrenia / Q000276:immunology*; D012563:Schizophrenia, Paranoid / Q000276:immunology; D013116:Spinal Cord / Q000276:immunology
D001323:Autoantibodies
K kharakteristike protivomozgovykh antitel pri shizofrenii po dannym metoda neprimaoĭ immunofliuorestsentsii i reaktsii pogloshcheniia komplementa.