Cinoxacin in therapy of urinary tract infections. Comparison of two dosage regimens.
TWo dosage regimens of cinoxacin, 250 mg. four times a day (QID) versus 500 mg. twice a day (BID), were compared for efficacy and safety in the treatment of initial and recurrent urinary tract infections. Patient dosage assignments were by a random table. Analysis of the 91 evaluable adult patients showed no difference between the two regimens, each group having 98 per cent bacteriologic cures at the five-to-nine-day post-therapy culture. The incidence of side effects was low and mild in degree.
D002937:Cinoxacin / Q000008:administration & dosage* / Q000009:adverse effects; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D004756:Enterobacteriaceae Infections / Q000188:drug therapy*; D004927:Escherichia coli Infections / Q000188:drug therapy; D005260:Female; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy; D008297:Male; D008826:Microbial Sensitivity Tests; D011512:Proteus Infections / Q000188:drug therapy; D011724:Pyridazines / Q000008:administration & dosage*; D011897:Random Allocation; D014552:Urinary Tract Infections / Q000188:drug therapy*
D011724:Pyridazines; D002937:Cinoxacin