Cell-mediated and humoral immune responses to chlamydial antigens in guinea pigs infected ocularly with the agent of guinea pig inclusion conjunctivitis.
Cell-mediated immune response and humoral response to chlamydial antigens were investigated in guinea pigs infected with the agent of guinea pig inclusion conjunctivitis (GPIC). Pronounced cell-mediated immune response to the homologous antigen, as well as to two other chlamydial antigens, 6BC (Chlamydia psittaci) and LB-1 (C. trachomatis), occurred in all infected animals. Cell-mediated immune response to GPIC, and to a lesser extent to 6BC and LB-1 as well, was enhanced with time after infection even without the re-inoculation of the infectious agent. Extensive cross-reactions among the three chlamydial antigens during the cell-mediated immune response appeared to be due to shared species-specific and group-reactive antigens. Serum antibody response was pronounced and uniform to GPIC; it was less marked to 6BC and LB-1, with fewer cross-reactions than seen in tests for cell-mediated immunity.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000942:Antigens, Bacterial; D002692:Chlamydia trachomatis / Q000276:immunology; D003235:Conjunctivitis, Inclusion / Q000175:diagnosis / Q000276:immunology*; D005620:Freund's Adjuvant / Q000494:pharmacology; D006168:Guinea Pigs; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008263:Macrophage Migration-Inhibitory Factors / Q000494:pharmacology; D012882:Skin Tests; D014373:Tuberculin / Q000276:immunology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D008263:Macrophage Migration-Inhibitory Factors; D014373:Tuberculin; D005620:Freund's Adjuvant