Renal growth after transplantation: infant kidney received by adolescent.
Renal growth and function were studied in a sixteen year old recipient of a renal transplant from a 16 month old cadaveric donor. Within one month, as measured by sequential inulin and creatinine clearances, glomerular filtration rate was 40 ml/min, which was more than 6 times the estimated pretransplant clearance. Ultrasound of the transplanted kidney revealed longitudinal growth from 7 cm at transplant to 11.5 cm by 8 weeks post-transplant. Radionuclide renal scintiphotography confirmed rapid functional and dimensional growth. There was no evidence of rejection, obstruction, or other complications during the time the allograft rapidly increased in size. Thus this case demonstrates a remarkable capacity of the human kidney to hypertrophy rapidly.
D000293:Adolescent; D002102:Cadaver; D006084:Graft Rejection; D006801:Humans; D007223:Infant; D007668:Kidney / Q000254:growth & development; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D008297:Male; D014184:Transplantation, Homologous