Intestinal peptidases and sucrase in coeliac disease.
The activities of microvillus aminopeptidase (microsomal, EC 3.4.11.2), dipeptidyl peptidase IV (EC 3.4.14.-), glycyl-leucine dipeptidase (EC 3.4.13.11), proline dipeptidase (EC 3.4.13.9), sucrase (EC 3.2.1.48) and gamma-glutamyl transpeptidase (EC 2.3.2.2) were measured in peroral intestinal biopsies taken from patients with coeliac disease in the acute phase and in remission. A comparison with the amounts of corresponding activities from a reference group showed that all the measured activities were significantly decreased in the acute phase of the disease. In patients in remission only microvillus aminopeptidase and dipeptidyl dipeptidase IV displayed a substantial depression as compared to the reference group. It is suggested that a primary mucosal digestion defect will result in lack of substrate for other intestinal enzymes. This is a situation comparable to starvation and may explain the variation in the grade of restitution for the different enzymes.
D000328:Adult; D000368:Aged; D002446:Celiac Disease / Q000178:diet therapy / Q000201:enzymology*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007422:Intestines / Q000201:enzymology*; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000378:metabolism*; D013393:Sucrase / Q000378:metabolism*
D013393:Sucrase; D010447:Peptide Hydrolases