title: Coronary spasm management with verapamil (Isoptin).
abstract: Because of recurrent chest pain, 17 patients with documented spasm in coronary arteries without severe atherosclerotic obstructions were treated with verapamil in an open trial, using doses of 120 mg/day to 480 mg/day (mean, 240 mg/day). Thirteen patients received additional oral isosorbide dinitrate (30 mg/day). Eleven patients became asymptomatic, and four experienced marked reduction in frequency of attacks (one to four a month). While two patients did not respond, in most patients verapamil was effective in preventing attacks of angina due to coronary spasm.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000209:etiology / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000150:complications* / Q000175:diagnosis; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013035:Spasm / Q000150:complications / Q000175:diagnosis; D014700:Verapamil / Q000627:therapeutic use*
chemical_list: D014700:Verapamil; D007548:Isosorbide Dinitrate