title: Protection against keratoconjunctivitis shigellosa induced by immunization with outer membrane proteins of Shigella spp.
abstract: Active immunization of guinea pigs and rabbits with outer membrane proteins (OMP) isolated from Shigella flexneri 3a and Shigella sonnei phase I protected the animals against keratoconjunctivitis shigellosa induced with the homologous or heterologous strain. Protection was also achieved in rabbits after passive immunization with anti-OMP immune serum. Active immunization with lipopolysaccharide of S. flexneri 3a did not protect rabbits against keratoconjunctivitis shigellosa.
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000276:immunology*; D004405:Dysentery, Bacillary / Q000517:prevention & control*; D006168:Guinea Pigs; D007114:Immunization; D007116:Immunization, Passive; D007637:Keratoconjunctivitis / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D008565:Membrane Proteins / Q000276:immunology; D011817:Rabbits; D012763:Shigella flexneri / Q000276:immunology
chemical_list: D001426:Bacterial Proteins; D008565:Membrane Proteins