Conversion of reactions to leprolin and lepromin in patients with lepromatous leprosy by the transfer factor.
Conversion of leprolin and early lepromin reactions was achieved by two injections of transfer factor made of lymphocytes from lepromin-positive tuberculoid leprosy patients. However, the late reaction to lepromin remained unchanged. The importance of the degree of sensitivity of the cell donor was demonstrated, and a booster dose was also found to be useful. The feasibility of using transfer factor in treatment of lepromatous leprosy is briefly discussed.
D000328:Adult; D000942:Antigens, Bacterial / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007916:Lepromin / Q000276:immunology*; D007918:Leprosy / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009166:Mycobacterium leprae / Q000276:immunology*; D014165:Transfer Factor / Q000276:immunology*; D014373:Tuberculin / Q000276:immunology
D000942:Antigens, Bacterial; D014165:Transfer Factor; D014373:Tuberculin; D007916:Lepromin