Rapid assessment of lidocaine in cardiac patients by enzyme immunoassay.
Lidocaine, a drug commonly used via intravenous infusion for the treatment of cardiac arrhythmias, is frequently effective but has the hazard of potential toxicity. Avoidance of toxicity and better control of therapy are shown to be markedly enhanced by a new method of rapidly measuring blood levels of lidocaine by enzyme immunoassay. Examples of the use of this technique, for drug monitoring in the settings of suspected toxicity, prospective therapy, dose response assessment, and the study of pharmacokinetics are presented.
D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D005260:Female; D006331:Heart Diseases / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007124:Immunoenzyme Techniques; D007700:Kinetics; D008012:Lidocaine / Q000009:adverse effects / Q000097:blood* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
D008012:Lidocaine