BCG induced immunity to Mycobacterium leprae in mice.
One to three BCG vaccinations were given to various groups of mice--25 to 2 days preceding challenge with Myco. leprae. Harvesting of Myco. leprae was done every month upto a period of 7 months. Lymph node enlargement was taken as an indicator of successful vaccination. An increasing degree of protection was noted in BCG immunised mice as observed by a reduced number of bacilli harvested. Protection afforded was proportional to the number of doses of BCG given.
D000818:Animals; D001500:BCG Vaccine / Q000276:immunology*; D007111:Immunity, Cellular; D007114:Immunization; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D009166:Mycobacterium leprae / Q000254:growth & development / Q000276:immunology*
D001500:BCG Vaccine