title: Benoxaprofen administered once a day: determination of optimum dosage schedule.
abstract: Six centers participated in a double-blind crossover study in patients with rheumatoid arthritis (RA) and osteoarthritis to evaluate the most advantageous timing of the daily dose of benoxaprofen. The study results revealed no significant difference between the morning and evening dose administered at a daily dose of 600 mg; however, more patients with RA preferred the evening dose.
mesh_terms: D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001583:Benzoxazoles / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D010146:Pain / Q000188:drug therapy; D011422:Propionates / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D001583:Benzoxazoles; D011422:Propionates; C011677:benoxaprofen