Adaptation of a Nigerian strain of Plasmodium falciparum to Panamanian Aotus trivirgatus.
A patent infection (more than 190 days duration) with Plasmodium falciparum, obtained directly from a patient who had been exposed to malaria in Nigeria, was established in a splenectomized Panamanian owl monkey, Aotus trivirgatus griseimembra. Subinoculations from the original monkey recipient into one splenectomized and two normal A. t. griseimembra produced primary patient parasitemias of 18-54 days duration. These results represent the first successful adaptation of P. falciparum from man to a monkey of Panamanian origin.
D000220:Adaptation, Biological; D000818:Animals; D001029:Aotus trivirgatus / Q000469:parasitology*; D002427:Cebidae / Q000469:parasitology*; D006801:Humans; D008288:Malaria / Q000635:transmission; D009549:Nigeria; D010176:Panama; D010963:Plasmodium falciparum / Q000254:growth & development*