[Induction of tolerance to alloantigens in adult mice].
The tolerance to allogeneic C57BL/6 cells (H--2b) was induced in adult CBA mice (H--2k). For tolerance induction three kinds of treatment were combined: thymectomy of adult CBA mice, intravenous inoculation of 1 x 10(8) spleen C57BL/6 cells and injection of 200 mg/kg of cyclophosphamide after 24 hours. Such a treatment of CBA mice resulted in long survival (up to 5 months) of allogeneic C57BL/L heart grafts. The data obtained in MLC reaction supported unresponsiveness of tolerant CBA mice to H-2 antigens of C57BL/6 mice. No lymphoid tissue chimerism was observed in tolerant mice.
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D006183:H-2 Antigens; D016027:Heart Transplantation; D006824:Hybridization, Genetic; D007108:Immune Tolerance / Q000187:drug effects; D008297:Male; D008722:Methods; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D013154:Spleen / Q000637:transplantation*; D013268:Stimulation, Chemical; D013934:Thymectomy; D014184:Transplantation, Homologous
D006183:H-2 Antigens; D003520:Cyclophosphamide
Induktsiia tolerantnosti k alloantigenam u vzroslykh mysheĭ.