An investigation of the immunosuppressive effects of niridazole and metronidazole in rat and baboon heterotopic cardiac allograft models.
Niridazole alone (at 50 mg/kg/day) and particularly in combination with azathioprine and prednisolone showed potent immunosuppressive activity, far surpassing that produced by conventional agents, in the rat heterotopic cardiac allograft model. Benzoylmetronidazole or metronidazole (at 50 mg/kg/day) either alone or in combination with azathioprine and prednisolone demonstrated little immunosuppressive activity. The potent immunosuppression obtained with niridazole in the rat could not be reproduced in the baboon heterotopic cardiac allograft model in the doses used; niridazole at 50 mg/kg/day seems to be toxic in this animal.
D000818:Animals; D001379:Azathioprine / Q000494:pharmacology; D006085:Graft Survival; D016027:Heart Transplantation; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D008795:Metronidazole / Q000494:pharmacology*; D009560:Niridazole / Q000494:pharmacology*; D010215:Papio; D011239:Prednisolone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D008795:Metronidazole; D011239:Prednisolone; D001379:Azathioprine; D009560:Niridazole