title: 3-Ethyl and 3-methyl ethers of 19-iodocholesterol as potential adrenal scanning agents.
abstract: 19-Iodocholesterol-131I, though useful as an adrenal scanning agent, was found to be unstable. However, the substitution of methoxyl and ethoxyl groups for the hydroxyl group in the 3 position rendered these derivatives much more stable in solid form than the parent compound. They showed concentration in the adrenals of dogs similar to that of 19-iodocholesterol itself and therefore may be useful as adrenal scanning agents.
mesh_terms: D015071:19-Iodocholesterol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D002784:Cholesterol / Q000031:analogs & derivatives*; D004285:Dogs; D007457:Iodine Radioisotopes; D008297:Male; D009928:Organ Specificity; D011865:Radioisotope Dilution Technique; D013329:Structure-Activity Relationship; D014018:Tissue Distribution
chemical_list: D007457:Iodine Radioisotopes; D015071:19-Iodocholesterol; C029095:19-iodocholesterol 3-methyl ether; C029096:19-iodocholesterol 3-ethyl ether; D002784:Cholesterol