title: Hypotensive effects of captopril administered centrally in intace conscious spontanously hypertensive rats and peripherally in anephric anaesthetized spontaneously hypertensive rats.
abstract: 1. The hypotensive response to captopril in anaesthetized spontanously hypertensive rats (SHR) is not modified by bilateral nephrectomy performed 1 or 24 h previously. 2. Intracerebroventricular injection (i.c.v.) of captopril (2 mg kg-1) significantly lowered blood pressure of conscious SHR over a 7-h period of observation but there was no significant blood pressure response to i.c.v. vehicle, or to intravenous captopril (2 mg kg-1) in SHR. 3. There was no significant blood pressure response to captopril (2 mg kg-1) i.c.v. in the normotensive Wistar Kyoto controls (NT-WK). 4. These results indicate that captopril can lower the blood pressure of SHR by mechanisms independent of the kidneys or the circulating renin-angiotensin system. 5. The hypotensive effect of central captopril in SHR but not in the NT-WK suggests biochemical differences between the brains of the two rat strains.
mesh_terms: D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D003243:Consciousness; D006973:Hypertension / Q000188:drug therapy*; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D009392:Nephrectomy; D011392:Proline / Q000031:analogs & derivatives*; D051381:Rats; D012083:Renin / Q000502:physiology
chemical_list: D011392:Proline; D002216:Captopril; D012083:Renin