Double-blind group comparative study of testosterone undecanoate and mesterolone in hypogonadal male patients.
A double-blind, randomized, group comparative study was performed in hypogonadal male patients in order to compare the effects on sexual activity and mental state of testosterone undecanoate (TU) and mesterolone (M). The TU-treated group contained 12 patients, and the M-treated group contained 14 patients. The variables of sexual activity and of mental state were scored an evaluated statistically by means of the nonparametric randomization test for 2 independent groups. TU induced a marked improvement of the sexual activity and of the mental state. After 4 weeks of treatment the effects were significantly better than in the M-treated group: libido (p less than 0.001), erections (p less than 0.01), ejaculations (p less than 0.05) and mental state (p less than 0.001).
D000328:Adult; D002986:Clinical Trials as Topic; D013196:Dihydrotestosterone / Q000031:analogs & derivatives*; D004311:Double-Blind Method; D004542:Ejaculation / Q000187:drug effects; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy* / Q000523:psychology; D007989:Libido / Q000187:drug effects; D008297:Male; D008655:Mesterolone / Q000627:therapeutic use*; D012725:Sexual Behavior / Q000187:drug effects; D013739:Testosterone / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D013196:Dihydrotestosterone; D008655:Mesterolone; D013739:Testosterone; C010792:testosterone undecanoate