[Anaphylactic shock in brown Norway rats with reagins and no precipitins in the blood (author's transl)].
Brown Norway rats have been actively sensitized against hen ovalbumine mixed with anti Bordella pertussis vaccine. After ten to twelve days, IgE are detected in the blood, but no precipitins. Anaphylactic shock induced by i.v. injection of 1 mg.100 g-1 body weight of ovalbumine is caracterized by a vascular collapse, the animal dying in about 15 minutes. This collapse is identical with the same general anaphylactic reaction as observed in the Wistar rats, which have large amounts of precipitins in the blood.
D000707:Anaphylaxis / Q000276:immunology* / Q000503:physiopathology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004049:Diethylcarbamazine / Q000494:pharmacology; D007073:Immunoglobulin E / Q000032:analysis*; D007213:Indomethacin / Q000494:pharmacology; D008784:Methysergide / Q000494:pharmacology; D010047:Ovalbumin / Q000276:immunology*; D011398:Promethazine / Q000494:pharmacology; D051381:Rats; D011935:Reagins / Q000032:analysis
D011935:Reagins; D007073:Immunoglobulin E; D010047:Ovalbumin; D011398:Promethazine; D004049:Diethylcarbamazine; D007213:Indomethacin; D008784:Methysergide
Choc anaphylactique chez le rat Brown Norway porteur d'immunoglobulines E antiovalbumine.