title: Once-daily atenolol in hypertensive Zimbabwean blacks. A double-blind trial using two different doses.
abstract: A double-blind within-patient study was carried out on Zimbabwean Blacks to investigate the effect of once-daily atenolol on hypertension in doses of 100 and 200 mg/d. Atenolol 200 mg produced significant changes in diastolic pressure readings taken in the supine and standing positions and after exercise; with atenolol 100 mg modest but non-significant changes occurred. These findings are less impressive than those previously reported in White subjects. We conclude that beta-adrenoceptor blocking agents should not be used as drugs of first choice for hypertension in our Black population.
mesh_terms: D000328:Adult; D001741:Black or African American; D000368:Aged; D001262:Atenolol / Q000008:administration & dosage*; D044383:Black People; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000008:administration & dosage*; D011674:Pulse / Q000187:drug effects; D015030:Zimbabwe
chemical_list: D011412:Propanolamines; D001262:Atenolol