The influence of angiotensin II antagonist postischemic acute renal failure.
In 34 dogs the effect of a 90-min period of warm ischemia on renal perfusion and function was studied with and without (Sar1, Ile8) angiotensin II treatment. In the first 3 h after the release of renal arterial occlusion, a significant influence of the angiotensin II antagonist on changes in postischemic vascular resistance, intrarenal hemodynamics and renal function could be demonstrated, all being well preserved in the treated group.
D015059:1-Sarcosine-8-Isoleucine Angiotensin II / Q000494:pharmacology*; D000208:Acute Disease; D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000209:etiology; D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors*; D000818:Animals; D001794:Blood Pressure; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate; D007668:Kidney / Q000098:blood supply; D008297:Male; D012039:Regional Blood Flow; D012078:Renal Artery Obstruction / Q000150:complications*; D012083:Renin / Q000097:blood
D000804:Angiotensin II; D015059:1-Sarcosine-8-Isoleucine Angiotensin II; D012083:Renin