Effect of a streptococcal preparation, OK-432, on hematopoietic spleen colony formation in irradiated mice.
In vivo effect of an immunostimulant, OK-432, on hematopoietic spleen colonies (CFU-S) was investigated in irradiated JCL/ICR mice. Administration of OK-432 i.p. at various times before and/or after irradiation resulted in a significant increase in endogenous CFU-S. This increase was further characterized microscopically by an increase in the number of megakaryocytic colonies. Transplantable exogenous CFU-S also increased when normal bone marrow cells were transplanted into irradiated recipient mice previously given OK-432 i.p. Treatment with OK-432 gave rise to an earlier recovery of granulocyte and, particularly, platelet counts in the peripheral blood after irradiation. All these findings indicate that an increase in CFU-S is associated with activated hematopoietic microenvironment by OK-432.
D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D001688:Biological Products / Q000008:administration & dosage*; D016026:Bone Marrow Transplantation; D003114:Colony-Forming Units Assay; D005260:Female; D006098:Granulocytes; D006412:Hematopoietic Stem Cells; D007274:Injections, Intraperitoneal; D007958:Leukocyte Count; D051379:Mice; D010844:Picibanil / Q000008:administration & dosage*; D010976:Platelet Count; D013154:Spleen / Q000166:cytology*
D001428:Bacterial Vaccines; D001688:Biological Products; D010844:Picibanil