Are results of immunosuppressive therapy influenced by immunogenetic markers?
A group of 157 children, 4-15 years old, suffering from various forms of glomerulonephritis were investigated. Associations between the HLA system and the clinical, morphological and therapeutic responses were looked for. The study revealed the following associations: chronic GN to B15 and B18; Schönlein-Henoch GN to B27, Bw35 and Bw40; focal GN to B18; mesangioproliferative GN to B27; susceptibility to corticosteroids to B18; resistance to corticosteroids to B15.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000188:drug therapy / Q000276:immunology*; D005938:Glucocorticoids / Q000627:therapeutic use*; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007125:Immunogenetics; D008854:Microscopy, Electron
D005938:Glucocorticoids; D006680:HLA Antigens