title: Cytostatics in the treatment of chronic and acute pancreatitis.
abstract: In two patients intraoperative examination ruled out the suspected diagnosis of pancreatic carcinoma and demonstrated chronic pancreatitis. The patients were subjected then to cyclic treatment with cytostatic agents. In view of satisfactory results of this treatment a trial of similar treatment was undertaken in another 4 patients with chronic pancreatitis diagnosed by exploratory laparatomy with histological examination of pancreatic biopsy specimens in cases associated with severe abdominal pains. The results were assessed subjectively and objectively. Trials of treatment of acute pancreatitis with 5-fluorouracil were undertaken also in two cases with good result.
mesh_terms: D000208:Acute Disease; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D010195:Pancreatitis / Q000188:drug therapy*; D013997:Time Factors; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D014750:Vincristine; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate