Effectiveness of insulin-glucose in preventing adrenaline-induced myocardial and systemic disturbances in the dog.
The aim of this study was to investigate whether insulin-glucose (IG) is able to prevent detrimental systemic and myocardial changes induced in healthy dog by adrenaline (AD) infused at a rate which mimics spontaneous secretion after coronary occlusion. Insulin (0.3 u/kg) and glucose (10% ml/kg) mixture was infused intravenously concurrently with AD (1.2 microgram/kg/min) for 4 h and blood values of FFA, triiodothyronine (T3) immunoreactive insulin (IRI) and glucose measured initially, after 2 and 4 h of infusion were compared with the values found in dogs infused with AD alone and with saline. IG suppressed a rise in FFA, attenuated a fall in T3, reversed AD-induced histoenzymatic changes in SDH and ATPase activity and completely prevented the development of mitochondrial alterations shown by electron microscopic study. These data provide evidence for usefulness of IG in preventing the consequences of catecholamine excess in acute stage of MI.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004285:Dogs; D004837:Epinephrine / Q000037:antagonists & inhibitors*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D014284:Triiodothyronine / Q000378:metabolism
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D014284:Triiodothyronine; D005947:Glucose; D004837:Epinephrine