Wide distribution of immunoreactive renin in nerve cells of human brain.
By use of the indirect peroxidase-antiperoxidase complex immunocytochemical technique, antibody to purified human renal renin was applied to formalin-fixed paraffin sections of human cadaver brain. Immune reaction products were observed in most nerve cells in all areas of the brain examined; staining was limited to the soma and proximal dendrites. These experiments have confirmed the presence of a renin-like substance in central nervous tissue and suggest a more generalized function for "brain renin" than was previously anticipated.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000166:cytology; D001923:Brain Chemistry; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D008875:Middle Aged; D009474:Neurons / Q000032:analysis*; D012083:Renin / Q000032:analysis* / Q000276:immunology / Q000502:physiology; D013116:Spinal Cord / Q000032:analysis / Q000166:cytology
D012083:Renin