title: Efficacy and safety of ibuprofen for hemophilic arthropathy.
abstract: The safety and usefulness of ibuprofen (Motrin) were evaluated in 15 patients suffering from hemophilic arthropathy via a double-blind protocol with individual crossover. No significant increase in hemorrhagic episodes or alteration in platelet function was observed. A decrease in morning stiffness was noted in nine patients, and three decreased markedly their use of other pain medications. We conclude that ibuprofen represents a relatively safe agent for the management of discomfort caused by hemophilic arthropathy in a select group of hemophilic patients.
mesh_terms: D000843:Ankle Joint / Q000187:drug effects; D001760:Bleeding Time; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004551:Elbow Joint / Q000187:drug effects; D006395:Hemarthrosis / Q000097:blood / Q000188:drug therapy*; D006400:Hematocrit; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use*; D007719:Knee Joint / Q000187:drug effects; D008297:Male; D010919:Placebos; D010974:Platelet Aggregation / Q000187:drug effects
chemical_list: D010919:Placebos; D007052:Ibuprofen