title: Cardiopulmonary effects of intermittent mandatory ventilation.
abstract: IMV is a combination of spontaneous and mechanical ventilation. For numerous reasons, IMV is potentially more advantageous than conventional techniques. By maintaining spontaneous breathing, mechanical augmentation can be titrated to adjust alveolar minute ventilation levels to normal, thereby decreasing the incidence of respiratory alkalemia. There are major differences between the cardiopulmonary effects of IMV and conventional mechanical ventilation. Spontaneous inspiration decreases Ppl and results in better distribution of inspired gas, a better V/Q, and less physiological dead space. In addition, transmural filling pressures, venous return, and cardiac output are more normal than during conventional mechanical ventilation. Maintenance of spontaneous ventilation lowers mean Paw and pulmonary vascular resistance. If venous admixture occurs, it can be minimized by titrating PEEP. Thus, more effective  therapy for hypoxemia is possible. If spontaneous breathing is to persist and be efective, work-of-breathing must be minimized. This can be accomplished best when a continuous flow of gas provides optimal CPAP to maintain FRC and to minimize the effects of decreased compliance without depressing cardiac function.
mesh_terms: D002302:Cardiac Output; D002320:Cardiovascular Physiological Phenomena; D006801:Humans; D007385:Intermittent Positive-Pressure Ventilation; D008954:Models, Biological; D011175:Positive-Pressure Respiration; D011312:Pressure; D011652:Pulmonary Circulation; D012123:Pulmonary Ventilation; D012119:Respiration; D014939:Work of Breathing