Perspectives of the chemical fate and toxicity of pesticides.
The wide-spread use of pesticides in modern agriculture has created a need to investigate the chemical transformation of pesticides in plants and animals. This paper reviews the chemical and biochemical fate of various pesticides and other xenobiotics. Photochemical mechanisms appear to be the most common pathways for the abiotic transformation of these chemicals. Biotic transformation includes a large group of biochemical reactions which may result in either deactivation (detoxication) or activation (toxication) of bioactive compounds. The need for quality control in the production of pesticides is also discussed.
D000818:Animals; D001673:Biodegradation, Environmental; D004347:Drug Interactions; D004790:Enzyme Induction / Q000187:drug effects*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010573:Pesticide Residues / Q000506:poisoning; D010575:Pesticides / Q000378:metabolism* / Q000506:poisoning; D010777:Photochemistry; D012987:Soil
D010573:Pesticide Residues; D010575:Pesticides; D012987:Soil; D006899:Mixed Function Oxygenases