[Mutagenic action of benz(a)pyrene and its metabolites in the in vitro Salmonella typhimurium-microsomes test system].
It has been shown that epoxides are responsible for the mutagenic action of benz(a)pyrene in the system. S. typhimurium. The mutagenic effect produced by 6-hydroxybenz(a)pyrene that is consequent on the free radical processes is reversed by alpha-tocopherol. Diolepoxides with spatially separated functional groups do not elicit any mutagenic effect.
D000818:Animals; D001580:Benzopyrenes / Q000378:metabolism / Q000494:pharmacology*; D005978:Glutathione / Q000494:pharmacology; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000187:drug effects*; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects*; D014810:Vitamin E / Q000494:pharmacology
D001580:Benzopyrenes; D009153:Mutagens; D014810:Vitamin E; D005978:Glutathione
Izuchenie mutagennogo deistviia benz(a)pirena i ego metabolitov v test-sisteme Salmonella typhimurium-mikrosomy in vitro.