Simultaneous pulsatile release of prolactin and luteinizing hormone induced by luteinizing hormone-releasing factor agonist.
Subcutaneous injection of 50 microgram long acting agonist of LRF (LRF-Ag) resulted in the prompt, simultaneous pulsatile release of both LH and PRL in four hypogonadal women. After repeated daily administration of LRF-Ag. LH release in response to LRF-Ag was markedly attenuated, and LH pulses were abolished. LRF-Ag induced PRL release was also attenuated but remained pulsatile. These findings demonstrate the dissociation of the LRF-Ag-induced contemporaneous release of LH and PRL and suggest a hypothalamic site of action of LRF-Ag on PRL release.
D004958:Estradiol / Q000097:blood; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D017329:Triptorelin Pamoate / Q000031:analogs & derivatives*
D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; C019176:Tryptal; D011388:Prolactin; D007986:Luteinizing Hormone