The abrogation of in vivo resistance to parental bone marrow transplantation and of in vitro natural cell-mediated cytotoxicity to the YAC lymphoma by in vivo growth of a transformed thymus-derived cell culture.
A thymus-derived monolayer culture, referred to as E1, from (C57Bl/6 X A)F1 hybrid mice was continuously passaged in vitro for over three years and formed rapidly growing, non-metastasizing tumors when injected s.c. into syngeneic mice. The spleens of tumor-bearing mice were greatly enlarged, but no tumor cells were detected in these spleens. The natural cell-mediated cytotoxic activity of spleen cells of tumor-bearing mice decreased with increasing tumor size. In addition, the expression of genetic resistance to transplantation of C57Bl/6 parental bone marrow cells was decreased in the spleens of irradiated tumor-bearing mice. This correlation between the expressions of natural cell-mediated cytotoxicity and of genetic resistance to bone marrow transplantation is consistent with the hypothesis that both of these responses are mediated by the same population of effector cells.
D000818:Animals; D016026:Bone Marrow Transplantation; D003114:Colony-Forming Units Assay; D005260:Female; D006084:Graft Rejection; D007165:Immunosuppression Therapy; D007694:Killer Cells, Natural / Q000276:immunology*; D008223:Lymphoma / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics; D008810:Mice, Inbred C57BL / Q000235:genetics; D009368:Neoplasm Transplantation; D051381:Rats; D013154:Spleen / Q000276:immunology*; D014181:Transplantation Immunology