title: [Genetic effects of N-nitroso-N-methylurea on Saccharomyces cerevisiae. II. Effect of radiosensitivity mutations on lethal and mutagenic effects].
abstract: Study of the lethal effect of NMU on radiosensitive strains rad2, rad54 and xrs2 of Saccharomyces cerevisiae has demonstrated that the mutations rad2 and rad54 increase the sensitivity of these strains to low doses of the mutagen. Mutations rad2, rad54 and xrs2 decreases the mutagenic effect of NMU. The study of nature of mutations induced by NMU in ade2 locus has shown that they are mainly the base substitutions. Mutations of radiosensitivity do not influence the nature of NMU-induced mutations in ade2 locus.
mesh_terms: D004260:DNA Repair; D008770:Methylnitrosourea / Q000494:pharmacology*; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D011836:Radiation Tolerance; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics*
chemical_list: D009153:Mutagens; D009607:Nitrosourea Compounds; D008770:Methylnitrosourea
vernacular_title: Izuchenie geneticheskikh éffektov N-nitrozo-N-metilmocheviny na drozhzhi Saccharomyces cerevisiae. Soobshchenie II. Vliianie mutatsiĭ radiochuvstvitel'nosti na letal'nyĭ i mutagennyĭ éffekty.