Renal isotransplantation without immunosuppression.
Four renal isografts have been performed and all have had satisfactory function for 7 1/2 to 17 2/3 years without prophylactic or therapeutic immunosuppression. Three of these patients originally had glomerulonephritis, and in one there was histologic evidence of recurrent disease, 7 1/2 years after transplantation, without proteinura and without change in renal function. Although this experience is small, it suggests that prophylactic immunosuppression is not appropriate for recipients of renal isografts.
D004200:Diseases in Twins; D005260:Female; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000601:surgery; D006085:Graft Survival; D006801:Humans; D007165:Immunosuppression Therapy; D007668:Kidney / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000648:ultrastructure; D016030:Kidney Transplantation; D008297:Male; D008854:Microscopy, Electron; D011247:Pregnancy; D011704:Pyelonephritis / Q000601:surgery; D012008:Recurrence; D013997:Time Factors; D014185:Transplantation, Isogeneic; D014430:Twins, Monozygotic