Antiviral, antibacterial and antitumor activity of the hydrazide and the ethyl ester of 2,2'-anhydro-1-(beta-D-arabinofuranosyl)-orotic acid.
It has been demonstrated that the hydrazide and the ethyl ester of 2,2'-anhydro-1-(beta-D-arabinofuranosyl) orotic acid inhibit selectively the multiplication of some DNA-containing viruses (PsRV, VV, AdV5), suppress the growth of E. coli and St. aureus in vitro and exhibit an antitumor effect with Lewis lung carcinoma and sarcoma 298.
D000818:Animals; D001087:Arabinonucleosides / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002642:Chick Embryo; D004267:DNA Viruses / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000187:drug effects
D001087:Arabinonucleosides; C028916:2,2'-anhydro-1-(beta-D-arabinofuranosyl)orotic acid ethyl ester; C028915:2,2'-anhydro-1-(beta-arabinofuranosyl)-orotic acid; C029817:2,2'anhydro-1-(beta-arabinofuranosyl)orotic acid hydrazide