Impaired cellular interactions involving lymphocytes from patients with chronic lymphocytic leukemia and ataxia-telangiectasia.
Abnormal cellular interactions between T and B lymphocytes were identified in patients with CLL and AT. The system employed utilized the detection of a newly recognized lymphokine, NIF-T. This mediator is produced by T lymphocytes as a result of the interaction between T and B cells. Our studies demonstrated impaired T cell function but normal B cell activity in patients with AT with respect to mitogenic stimulation and MLC reactivity. In contrast, patients with B cell CLL had normal T cell function. The leukemic B cells from these patients, however, failed to collaborate with normal T cells in response to mitogens, and they did not participate in MLC reactions. In contrast, lymphocytes from patients with HCL functioned normally with respect to NIF-T production.
D000328:Adult; D000368:Aged; D001260:Ataxia Telangiectasia / Q000276:immunology*; D001402:B-Lymphocytes / Q000378:metabolism; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology*; D007961:Leukocyte Migration-Inhibitory Factors / Q000378:metabolism; D008211:Lymphocyte Cooperation; D008222:Lymphokines / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism
D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines