title: Once-daily dosing of timolol in hypertension: a controlled study.
abstract: Nine previously untreated patients with mild-moderate hypertension were included in a dose-ranging double-blind trial to determine the effectiveness of daily versus thrice daily timolol administration. In 8 patients control of blood pressure was equally effective though with significantly lower heart rate achieved in the once daily group. One patient was not satisfactorily controlled on the daily regimen demostrating that many but not all hypertensives can be controlled with daily administration of timolol.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011412:Propanolamines / Q000008:administration & dosage*; D013999:Timolol / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D010919:Placebos; D011412:Propanolamines; D013999:Timolol