[Quantitative-morphological changes of capillaries and neurons in the aging human putamen (author's transl)].
Stereological investigations (Classimat) of the capillary net of 4 age-groups, ranging between 19 and 94 years, revealed significant increase of capillary volume and total length, and decreased intercapillary distances in the aging putamen. Neuronal size and shape measurements (Texture-Analyzer-System) of the same brain region showed significant changes between the young (19-44 y.) and oldest (85-94 y.) group, indicating senile atrophy of the neuronal perikarya. Quantitative image-analysis facilitates to evaluate new morphometrical data of the aging process in the human brain, which are important for a pharmacological concept of treating cerebral insufficiency symptoms.
D000328:Adult; D000368:Aged; D000375:Aging; D002196:Capillaries / Q000033:anatomy & histology; D006652:Histological Techniques; D006801:Humans; D008853:Microscopy; D008875:Middle Aged; D009474:Neurons / Q000166:cytology*; D011699:Putamen / Q000033:anatomy & histology* / Q000098:blood supply
Quantitativ-morphologische Altersveränderungen von Kapillaren und Neuronen im menschlichen Putamen.