title: Uptake of aggregated immunoglobulin by the mouse kidney. II. Effect of hydrocortisone.
abstract: The uptake of radiolabelled (125I) aggregated human IgG (AggIgG) by the renal cortex, liver, spleen and lung was evaluated quantitatively in mice treated with hydrocortisone (HC) (25 mg) 72 h previously. AggIgG was administered in a dose of 1.5 or 3.5 mg/g body wt i.v.; tissue and blood were obtained at 1, 4 and 24 h. Renal cortical and mesangial uptake of AggIgG was significantly increased in HC animals. A rise in blood level was also observed in association with decreased splenic uptake, normal or slightly increased hepatic uptake and unchanged lung uptake. A significant increase in the kidney:lung and kidney:spleen ratios of AggIgG was induced by hydrocortisone, suggesting a relatively greater rate of loss from the spleen and liver than the renal cortex. The increased mesangial uptake may be a consequence of higher blood levels of AggIgG, as well as a direct effect of HC on the mesangium.
mesh_terms: D000818:Animals; D005455:Fluorescent Antibody Technique; D006854:Hydrocortisone / Q000494:pharmacology*; D007074:Immunoglobulin G / Q000378:metabolism*; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D046911:Macromolecular Substances; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000187:drug effects / Q000378:metabolism
chemical_list: D007074:Immunoglobulin G; D046911:Macromolecular Substances; D006854:Hydrocortisone