title: Differential amplification of specific areas of phage T4 genome as revealed by hybridization to cloned genetic segments.
abstract: Under various conditions, specific genetic areas of the phage T4 DNA molecule are preferentially and repeatedly replicated, resulting in the amplification of these areas. These areas are found to lie in the vicinity of the known origins of DNA replication.
mesh_terms: D002499:Centrifugation, Density Gradient; D002701:Chloramphenicol / Q000494:pharmacology; D003001:Cloning, Molecular; D004261:DNA Replication; D004279:DNA, Viral / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics; D005784:Gene Amplification / Q000187:drug effects; D008957:Models, Genetic; D009693:Nucleic Acid Hybridization; D013604:T-Phages / Q000235:genetics*
chemical_list: D004279:DNA, Viral; D002701:Chloramphenicol