Antagonists of morphine-induced respiratory depression. A study in postoperative patients.
This double blind study showed the effect of four drugs, levallorphan, naloxone, doxapram and amiphenazole, an opiate-induced analgesia and respiratory depression. Satisfactory analgesia was induced by administration of morphine intravenously in a dose of up to 0.33 mg/kg; such a dose, however, produced significant depression of respiration. Administration of levallorphan, naloxone, and amiphenazole produced reversal of respiratory depression and analgesia. Doxapram reversed the respiratory depression but did not alter analgesia.
D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004315:Doxapram / Q000627:therapeutic use; D006801:Humans; D007977:Levallorphan / Q000627:therapeutic use; D008875:Middle Aged; D009020:Morphine / Q000009:adverse effects / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D009270:Naloxone / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy; D011897:Random Allocation; D012131:Respiratory Insufficiency / Q000139:chemically induced / Q000188:drug therapy*; D013844:Thiazoles / Q000627:therapeutic use; D013997:Time Factors
D009292:Narcotic Antagonists; D013844:Thiazoles; D007977:Levallorphan; D009270:Naloxone; D009020:Morphine; C004484:amiphenazole; D004315:Doxapram