[Functional state of the renin-angiotensin system in the diuretic therapy of hypertension].
The functional condition of the renin-angiotensin system (RAS) was studied according to the level of plasma-renin activity determined under basal conditions and after walking prior to and after 3 days of medication with furosemide and after a course of hydrochlorothiazide treatment. The authors studied 34 males from 22 to 45 years of age with an uncomplicated course of hypertensive disease and labile or stable hypertension. Three groups of patients were distinguished according to the reaction of renin activity to walking in the control period: I, normorenin with normal basal level of renin activity, a somewhat reduced but within normal ranges and gradually growing during treatment RAS reaction; II, hyperrenin with a higher basal level of renin activity which increased sharply after stimulation by walking and furosemide; III, hyporenin with a very low basal level of renin activity which was areactive to stimulation by walking and hyporeactive to stimulation by furosemide. The hypotensive effect of diuretics was higher in patients of group II. In group III patients there was a prevalent decrease in sytolic arterial pressure. No connection was found between the decrease in arterial pressure and the decrease in the volume of circulating plasma.
D000328:Adult; D000804:Angiotensin II / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D005665:Furosemide / Q000008:administration & dosage*; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage*; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects; D012083:Renin / Q000097:blood / Q000502:physiology*; D013997:Time Factors
D006852:Hydrochlorothiazide; D000804:Angiotensin II; D005665:Furosemide; D012083:Renin
Funktsional'noe sostoianie renin-angiotenzinnoĭ sistemy pri lechenii gipertonicheskoĭ bolezni diuretikami.