title: The chronic leukemias.
abstract: Chronic granulocytic leukemia, chronic lymphocytic leukemia and its variants, and hairy cell leukemia are characterized by prominent organ infiltration and marrow replacement, with a course consisting of years. Although treatment is effective in ameliorating symptoms, little has been gained in terms of increased survival.
mesh_terms: D000328:Adult; D002066:Busulfan / Q000627:therapeutic use; D002904:Chromosomes, Human, 21-22 and Y; D002908:Chronic Disease; D006801:Humans; D007938:Leukemia / Q000175:diagnosis*; D007943:Leukemia, Hairy Cell / Q000175:diagnosis / Q000628:therapy; D007945:Leukemia, Lymphoid / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D007951:Leukemia, Myeloid / Q000175:diagnosis* / Q000188:drug therapy; D008875:Middle Aged; D011379:Prognosis; D013156:Splenectomy; D013601:T-Lymphocytes
chemical_list: D002066:Busulfan