Immunological properties of athymic nude mice born from homozygous (nu/nu) parents.
No significant differences were observed between nude mice (nu/nu) born of homozygous (nu/nu) parents and those born of heterozygous (nu/+) mothers in the percentage of Thy-1-positive cells or immunoglobulin (Ig)-bearing cells in the spleen as assessed by immunofluorescence. There were no significant differences in the antibody response to thymus-dependent antigen or in the number of background plaque-forming cells to this antigen. The antibody response to thymus-independent antigen was not imparied at all in mice born from homozygous parents as compared with other nude mice or euthymic mice. It was concluded that the Thy-1-bearing (T) cells observed in nu/nu mice and the capacity of these mice to respond to thymus-dependent antigens arose independently of maternal T cells and of the influence of the maternal thymus.
D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D006462:Hemolytic Plaque Technique; D006579:Heterozygote; D006720:Homozygote; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008819:Mice, Nude / Q000235:genetics / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology