Enhanced release of a 'prostacyclin-like' substance from aortic strips of spontaneously hypertensive rats.
The release of an endogenous 'prostacyclin-like' substance from aortic strips of 8 male Wistar rats of the New Zealand genetically hypertensive strain (GH) was compared with that of 8 weight, age and sex matched normotensive Wistar control rats. The amount of 'prostacyclin-like' substance released by the aortic strips into tris buffer, under the influence of mechanical stimulation, was measured by its ability to inhibit human platelet aggregation as compared to the inhibitory effect of standard prostacyclin sodium salt. It was shown that generation of this substance increased with incubation time and that a significantly greater amount was produced by GH rats.
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism*; D011464:Epoprostenol / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats
D011453:Prostaglandins; D011464:Epoprostenol