title: Monitoring pediatric serum theophylline, phenobarbital, and phenytoin with the IL Multistat III.
abstract: We compared results of theophylline, phenobarbital, and phenytoin assays by the EMIT method using the IL Multistat III Micro Centrifugal Analyzer with results by the EMIT semiautomated procedure on a Beckman 25 spectrophotometer equipped with a semiautomated pipettor-dilutor and a model 2400 automatic timer/printer. We assessed linearity, precision, specificity, and correlation with other methods, The IL MCA III is precise, easy to use, and suitable for routine use in a pediatric laboratory. Only 3 microliter of serum is used for each drug analysis, and 17 results can be obtained in 8 min. Reagent costs can be reduced fourfold.
mesh_terms: D001774:Blood Chemical Analysis / Q000295:instrumentation*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007231:Infant, Newborn; D008905:Minicomputers; D010634:Phenobarbital / Q000097:blood*; D010672:Phenytoin / Q000097:blood*; D011786:Quality Control; D013806:Theophylline / Q000097:blood*
chemical_list: D010672:Phenytoin; D013806:Theophylline; D010634:Phenobarbital