Effect of vitamin E therapy on blood coagulation tests in newborn infants.
A double-blind randomized trial of vitamin E therapy was conducted in premature infants whose birth weight was less than 1,500 gm. Treated infants received 25 mg of vitamin E daily by mouth for the first six weeks of life. Detailed studies of plasma coagulation factors were performed prior to therapy and at days 7 and 42. None of the factors differed significantly between the treated and control groups. Although vitamin E therapy has been reported to affect the blood levels of vitamin K dependent coagulation factors, no such effect was noted in this group of premature infants.
D001777:Blood Coagulation; D001779:Blood Coagulation Factors; D001780:Blood Coagulation Tests; D002986:Clinical Trials as Topic; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D014810:Vitamin E / Q000494:pharmacology / Q000627:therapeutic use*
D001779:Blood Coagulation Factors; D014810:Vitamin E