Effect of total body X-irradiation on the hexobarbital oxidase activity in the rat liver.
It is established that the hexobarbital oxidase activity of 12,000 g rat liver supernatant does not change when examined at the 2nd h after whole body irradiation (700 R) but increases at longer postexposure periods (72 hours). Intraperitoneal injection of phenobarbital in daily doses of 80 mg/kg body wt for three days increases the hexobarbital oxidase activity of non-irradiated rats, the effect being much stronger in phenobarbital-treated rats at the 2nd h of postirradiation. The possible mechanisms of these effects are discussed, as well as their correlation with the increased lipid peroxidation and their significance for the radiation effect on the drug action.
D000429:Alcohol Oxidoreductases / Q000528:radiation effects*; D000633:Aminopyrine N-Demethylase / Q000528:radiation effects; D000818:Animals; D004790:Enzyme Induction / Q000187:drug effects; D006591:Hexobarbital / Q000528:radiation effects; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000528:radiation effects*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D014965:X-Rays
D008054:Lipid Peroxides; D006591:Hexobarbital; D000429:Alcohol Oxidoreductases; C021353:hexobarbital oxidase; D000633:Aminopyrine N-Demethylase; D010634:Phenobarbital