Decrease in susceptibility of Plasmodium falciparum to mefloquine in continuous culture.
Chloroquine-resistant P. falciparum, line FCK from Thailand, was tested for susceptibility to mefloquine in continuous culture. The drug resulted in 50% schizont inhibition at the level of 8.0 nmol/ml of culture when tested for the first time. After three months of discontinuous exposure to mefloquine at increasing levels, the sensitivity of the parasite decreased. A concentration as high as 128 nmol/ml eventually was required for 50% inhibition of growth.
D000818:Animals; D002738:Chloroquine / Q000494:pharmacology; D003470:Culture Media; D004352:Drug Resistance, Microbial; D006801:Humans; D066298:In Vitro Techniques; D008288:Malaria / Q000469:parasitology*; D015767:Mefloquine; D010880:Piperidines / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D011804:Quinolines / Q000494:pharmacology*
D003470:Culture Media; D010880:Piperidines; D011804:Quinolines; D002738:Chloroquine; D015767:Mefloquine