Effect of cyproterone acetate on platelet aggregability, fibrinolytic activity and fibrinolytic capacity in normal men.
Nine healthy men were treated with a daily dose of 5 or 10 mg of the anti-androgen cyproterone acetate. Platelet aggregability was increased in 6 of 9 men; fibrinolytic activity decreased in 7 of 7 and the fibrinolytic capacity decreased in 5 of 7 volunteers. We conclude that platelet aggregability, fibrinolytic activity and capacity may be modified by anti-androgen treatment and therefore attention should be paid to the coagulation parameters when cyproterone acetate is used.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D002986:Clinical Trials as Topic; D003534:Cyproterone / Q000009:adverse effects / Q000494:pharmacology*; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*
D000244:Adenosine Diphosphate; D003534:Cyproterone