Salivary concentrations of amphotericin B following its use as an oral lozenge.
Amphotericin B concentrations were measured in the saliva of ten healthy volunteers who had sucked on lozenges with this drug. It appeared that high amphotericin B concentrations can be achieved in this way in the saliva. Even half an hour after swallowing the last remnant of a lozenge, the amphotericin B concentration was found to be high enough to suppress the growth of sensitive Candida albicans strains. The possible usefulness of amphotericin B lozenges in the selective decontamination of the oropharynx of yeasts and other fungi is discussed and compared with the application of this drug in orabase.
D000284:Administration, Oral; D000666:Amphotericin B / Q000008:administration & dosage / Q000032:analysis* / Q000627:therapeutic use; D002176:Candida albicans / Q000187:drug effects; D002180:Candidiasis, Oral / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D012463:Saliva / Q000032:analysis*
D000666:Amphotericin B