Antioxidant-mediated increases in the antifungal activities of amphotericin B and its methyl ester derivative.
Although antioxidants enhanced the antifungal properties of both amphotericin B and its methyl ester derivative, the effect was significantly more pronounced with amphotericin B. This disparity is explained on the basis of differences observed in the dynamics of drug action.
D000666:Amphotericin B / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000935:Antifungal Agents; D000975:Antioxidants / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D004357:Drug Synergism; D011435:Propyl Gallate / Q000494:pharmacology
D000935:Antifungal Agents; D000975:Antioxidants; C017501:methylamphotericin B; D000666:Amphotericin B; D011435:Propyl Gallate