Nalidixic acid inhibition of post-ultraviolet recovery by nalidixic acid sensitive and resistant strains of Candida albicans.
Nalidixic acid (Nal) can kill Candida albicans directly or suppress the organism's recovery from ultraviolet irradiation. Mutants selected for resistance to inactivation by Nal alone have generally enhanced DNA repair proficiencies evidenced by their coincident increased resistances to ultraviolet radiation, ethylmethane sulfonate, and nitrous acid. The effects of Nal, erythromycin, and inhibitors of oxidative phosphorylation on survivals of mutant and wild type strains following ultraviolet exposure indicate that different mechanisms underly the direct lethality of Nal and its ability to inhibit post-irradiation recovery.
D002176:Candida albicans / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D004260:DNA Repair; D004271:DNA, Fungal / Q000378:metabolism; D004352:Drug Resistance, Microbial; D005020:Ethyl Methanesulfonate / Q000494:pharmacology; D009154:Mutation; D009268:Nalidixic Acid / Q000494:pharmacology*; D009608:Nitrous Acid / Q000494:pharmacology; D010085:Oxidative Phosphorylation; D014466:Ultraviolet Rays
D004271:DNA, Fungal; D009268:Nalidixic Acid; D005020:Ethyl Methanesulfonate; D009608:Nitrous Acid