Pressor factors and cardiovascular pressor reponsiveness in essential hypertension.
The sympathetic system, the body sodium-fluid volume state, the reninangiotensin system, functional and structural characteristics of the heart and blood vessels, and some other components are important complementary factors in blood pressure regulation. A deviation from the normal equilibrium among these components, with a persisting non-physiologic increase in pressor factor(s) or in the basal vascular tone and/or cardiovascular reactivity to pressor factors, leads to hypertension. This review discusses recent observations and concepts regarding the roles of various pressor factors as well as cardiovascular pressor responsiveness in the pathogenesis of essential hypertension and in the anti-hypertensive mechanism of diuretic treatment.
D000804:Angiotensin II / Q000502:physiology; D001794:Blood Pressure; D002319:Cardiovascular System / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D011388:Prolactin / Q000502:physiology; D012083:Renin / Q000502:physiology; D012964:Sodium / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology
D000804:Angiotensin II; D011388:Prolactin; D012964:Sodium; D012083:Renin