title: Long-term sequelae of cancer chemotherapy.
abstract: Long-term sequelae of therapy of neoplastic disease have become an important topic, since many patients exposed to anticancer drugs will have prolonged survival. The advances which have been made in the treatment of pediatric malignancies, in fact, give particular relevance to a study of these complications. Moreover, clues as to the mechanism of action and molecular pharmacology of these agents may emerge from such studies. Herein we review both the specific organ dysfunction and the generalized effects which may become apparent as late consequences of chemotherapy.
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D002493:Central Nervous System Diseases / Q000139:chemically induced; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D004700:Endocrine System Diseases / Q000139:chemically induced; D006066:Gonads / Q000187:drug effects; D006128:Growth / Q000187:drug effects; D006331:Heart Diseases / Q000139:chemically induced; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D007109:Immunity / Q000187:drug effects; D007674:Kidney Diseases / Q000139:chemically induced; D009369:Neoplasms / Q000188:drug therapy*; D013723:Teratogens
chemical_list: D000970:Antineoplastic Agents; D013723:Teratogens