Stress-induced analgesia: neural and hormonal determinants.
Extensive evidence has indicated that distinct neural systems specifically designed to inhibit sensitivity to painful stimuli exist. Recent advances suggest that the endorphins, enkephalins and the opiate receptor interact with a descending serotonergic bulbospinal system to mediate the analgesic responses to opiates and electrical stimulation. In assessing the evolutionary and behavioral significance of this pain-inhibitory system, several laboratories discovered that acute exposure to a wide variety of stressful events results in a transient analgesia. Chronic exposure to a number of these stressors results in adaptation of the analgesic response. The purpose of this review is to identify and characterize the mechanisms by which these stressors activate pain-inhibition. The relationship of stress-induced analgesia to each of the following is reviewed: (a) the role of endorphins, enkephalins and the opiate receptor; (b) the role of the descending serotonergic bulbospinal system; (c) the role of the pituitary gland; and (d) the role of hypothalamic mechanisms. Data will be discussed in terms of "opiate" and "non-opiate" pain-inhibitory mechanisms, in which some stressors act through the former and other stressors act through the latter.
D000698:Analgesia; D000818:Animals; D002490:Central Nervous System / Q000503:physiopathology*; D003847:Deoxyglucose / Q000494:pharmacology; D004357:Drug Synergism; D004361:Drug Tolerance; D004525:Efferent Pathways / Q000503:physiopathology; D006728:Hormones / Q000502:physiology*; D007031:Hypothalamus / Q000503:physiopathology; D008636:Mesencephalon / Q000503:physiopathology; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone; D010146:Pain / Q000503:physiopathology*; D010902:Pituitary Gland / Q000503:physiopathology; D011903:Raphe Nuclei / Q000503:physiopathology; D051381:Rats; D012684:Sensory Thresholds; D012701:Serotonin / Q000502:physiology; D013116:Spinal Cord / Q000503:physiopathology; D013312:Stress, Physiological / Q000503:physiopathology*; D013376:Substantia Gelatinosa / Q000503:physiopathology
D006728:Hormones; D012701:Serotonin; D009270:Naloxone; D009020:Morphine; D003847:Deoxyglucose