Bacterial phagocytosis by macrophages from lipopolysaccharide responder and nonresponder mouse strains.
The phagocytic capacity of macrophages from C3H/H3J mice was assessed against lipopolysaccharide-producing (Escherichia coli) and -nonproducing (Staphylococcus aureus) bacteria. Despite their gene-coded unresponsiveness to lipopolysaccharide endotoxin and lymphokines and their defective tumoricidal activity, proteose peptone-induced C3H/HeJ macrophages did not display a defective phagocytic capacity, but rather displayed an enhanced phagocytosis of both bacterial strains compared with macrophages from closely related C3H/HeN mice. Unstimulated peritoneal resident C3H/HeJ macrophages, on the other hand, displayed a normal phagocytic activity toward E. coli and enhanced phagocytosis toward S. aureus.
D000818:Animals; D004926:Escherichia coli / Q000276:immunology* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000096:biosynthesis / Q000494:pharmacology*; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D010587:Phagocytosis; D013211:Staphylococcus aureus / Q000276:immunology* / Q000378:metabolism
D008070:Lipopolysaccharides