[Pathogenesis of salmonelloses. Fate of the agent in the early stages of the experimental infectious process].
The fate of S. typhimurium was followed during the first 5 hours after infection, and a high invasive activity of Salmonella was revealed. After the oral and enteral infection of the animals with several billion organisms, the latter penetrated the blood and internal organs within 10 minutes. When introduced orally, the organisms disseminated by the hematogenic route primarily in the regional lymph nodes and the lungs, but through the blood the infective agent also penetrated the liver and persisted in this organ for a longer period, accumulating in a considerable amount. 10-30 minutes after infection by introducing Salmonella into the lumen of the duodenum most of the organisms were localized in the intestinal tissue, mesenterial lymph nodes and the liver. The organisms persisted in the mouth cavity and the pharynx during the whole period of observation, but in the contents of the intestine they not only stopped proliferating, but quickly died.
D000818:Animals; D004064:Digestive System / Q000382:microbiology*; D008099:Liver / Q000382:microbiology; D008168:Lung / Q000382:microbiology; D008198:Lymph Nodes / Q000382:microbiology; D010614:Pharynx / Q000382:microbiology; D011817:Rabbits; D012481:Salmonella Infections, Animal / Q000150:complications / Q000382:microbiology*; D012486:Salmonella typhimurium; D018805:Sepsis / Q000150:complications
K patogenezu sal'monellezov--sud'ba vozbuditelia na ranneĭ stadiĭ éksperimental'nogo infektsionnogo protsessa.