Comparative evaluation of the factors regulating vascular resistance in dogs, anesthetized with morphine-chloralose or pentobarbital.
Factors regulating hindlimb vascular resistance were comparatively evaluated in groups of mongel dogs anesthetized either with sodium pentobarbital(p) or morphine + chloralose (M + C). Pressure flow curved obtained in the perfused hindlimb studies indicated that, while the overall hindlimb resistance is greater in M + C group, the resting neurogenic tone and the tone contributed by circulating catecholamines were essentially similar in both groups. Thus the data suggest that myogenic activity is greater under M + C anesthesia, and this phenomenon may be related to differences in the plasma renin activity noted in the two groups. Vasodilator responses to isoproterenol and acetylcholine were not different between the groups while the vasoconstrictor responses to norepinephrine were greater in M + C group. It is suggested that the differences noted in the vascular profile of dogs under these two anesthetics may have some influence on the pharmacological effect of agents studied.
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D002698:Chloralose / Q000494:pharmacology; D004285:Dogs; D005260:Female; D006614:Hindlimb / Q000294:innervation; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009129:Muscle Tonus / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology; D012083:Renin / Q000097:blood; D013564:Sympathetic Nervous System / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects*
D000777:Anesthetics; D002698:Chloralose; D009020:Morphine; D012083:Renin; D010424:Pentobarbital