Renal manifestations of drug-induced systemic lupus erythematosus.
Renal failure secondary to crescentic glomerulonephritis developed in a patient who had typical serologic features of drug-induced systemic lupus erythematosus after two years of therapy with procainamide. Renal function and proteinuria improved after the drug was discontinued and steroid therapy begun. A review of previously reported cases of glomerulonephritis in association with drug-induced systemic lupus erythematosus revealed a high incidence of renal failure. Crescentic glomerulonephritis has not to our knowledge been previously documented in drug-induced systemic lupus erythematosus.
D001706:Biopsy; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D011342:Procainamide / Q000009:adverse effects
D011342:Procainamide