Double immunofluorescence studies on IgA-associated immune-complexes in glomerular deposits in patients with IgA nephropathy.
A study on double immunofluorescent staining of immunoglobulins and complement in IgA-associated immune-complexes of glomerular deposits in patients with IgA nephropathy is described. The components of immune-complexes deposited in kidney tissues included IgA, IgG, IgM, IgE, C3, C3A, properdin, Clq and C4. Although the majority of the deposits consisted of IgA and C3, some deposits showed the coexistence of other classes of immunoglobulins and C3 as well as other types of complement. It was suggested that the immune-complexes deposited in the glomeruli of patients with IgA nephropathy have a polyclonal nature.
D000936:Antigen-Antibody Complex / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007674:Kidney Diseases / Q000276:immunology*; D007678:Kidney Glomerulus / Q000276:immunology*
D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A