Calcinosis in dermatomyositis treated with probenecid.
Childhood dermatomyositis is frequently complicated by deposition of calcium salts in the soft tissues. This calcinosis represents a major problem, as severe disability may result. Various drugs have been tried to dissolve the calcinosis, but the results of these trials are disappointing. In this article we present a case report of a 9-year-old girl treated with probenecid. This treatment led to a dramatic decrease in subcutaneous and intermuscular calcinosis. The authors call for controlled studies of probenecid treatment in calcinosis.
D002114:Calcinosis / Q000188:drug therapy* / Q000209:etiology; D002648:Child; D002986:Clinical Trials as Topic; D003882:Dermatomyositis / Q000150:complications*; D005260:Female; D006801:Humans; D011339:Probenecid / Q000627:therapeutic use*
D011339:Probenecid