Haemorheological role of platelet aggregation and hypercoagulability in microcirculation: therapeutical approach with pentoxifylline.
The pathophysiology of disturbances in platelet function and intravasal hypercoagulability in diseases with impaired microcirculation is reviewed, and related relevant experimental and clinical findings with pentoxifylline are presented. Recent studies have revealed the antithrombotic properties of pentoxifylline which contribute to its haemorheological profile and therapeutical efficacy.
D001777:Blood Coagulation / Q000187:drug effects*; D001778:Blood Coagulation Disorders / Q000188:drug therapy*; D005343:Fibrinolytic Agents; D006801:Humans; D008833:Microcirculation / Q000187:drug effects*; D010431:Pentoxifylline / Q000627:therapeutic use*; D010974:Platelet Aggregation / Q000187:drug effects*; D013805:Theobromine / Q000031:analogs & derivatives*
D005343:Fibrinolytic Agents; D013805:Theobromine; D010431:Pentoxifylline