title: Prevention of endotoxin-induced arterial hypoxaemia and lactic acidosis with flunixin meglumine in the conscious pony.
abstract: Bacterial endotoxin injected intravenously into conscious ponies produced alterations in cardiopulmonary and gastrointestinal function. Specifically, tachypnoea, dyspnoea, hypoxaemia, colic, lactic acidosis and diarrhoea resulted from administration of 10 micrograms/kg Escherichia coli endotoxin. Pretreatment of the ponies with a potent prostaglandin synthetase inhibitor, flunixin meglumine, prevented these ill effects of endotoxin.
mesh_terms: D000138:Acidosis / Q000517:prevention & control / Q000662:veterinary*; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D001784:Blood Gas Analysis / Q000662:veterinary; D002339:Carotid Arteries; D003002:Clonixin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D004731:Endotoxins; D004926:Escherichia coli; D006734:Horse Diseases / Q000517:prevention & control*; D006736:Horses; D000860:Hypoxia / Q000517:prevention & control / Q000662:veterinary*; D007773:Lactates / Q000097:blood*; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D009539:Nicotinic Acids / Q000627:therapeutic use*
chemical_list: D001639:Bicarbonates; D004731:Endotoxins; D007773:Lactates; D009539:Nicotinic Acids; D008536:Meglumine; C014558:flunixin meglumine; D003002:Clonixin