Variation of the frameshift activity of a mutagen (ICR-191) following nitrosation in human gastric juice.
The acridine half-mustard mutagen ICR-191 elicits peculiar frameshift mutations in S. typhimurium, which are greatly decreased in the presence of rat liver preparations. Following in vitro preincubation of ICR-191 with sodium nitrite and human gastric juice, these patterns of mutation are replaced by frameshift errors requiring metabolic activation and showing a different molecular specificity.
D000585:Aminacrine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D000609:Aminoacridines / Q000494:pharmacology*; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism*; D009573:Nitrites / Q000378:metabolism; D009588:Nitrogen Mustard Compounds / Q000378:metabolism / Q000494:pharmacology*; D009603:Nitroso Compounds / Q000378:metabolism; D012486:Salmonella typhimurium / Q000187:drug effects
D000609:Aminoacridines; D009153:Mutagens; D009573:Nitrites; D009588:Nitrogen Mustard Compounds; D009603:Nitroso Compounds; D000585:Aminacrine; C004294:acridine half-mustard