A microstereotactic approach to small CNS lesions. Part II; Adjuvant therapy. Clinical potential and toxicity of intraventricular lymph infusion.
A technique is described for adjuvant therapy of small central nervous system tumors after their removal. The feasibility of direct application of lymphocytes from the thoracic duct to the ventricular system of cats has been explored. Reduction of the antigenic mass by techniques described in part I of this paper is probably crucial. Patients with gliomas are known to have circulating tumor-specific lymphocytes which may not have direct access to the CNS. This study demonstrated no toxicity from the chronic intraventricular infusion of thoracic duct lymph in cats.
D000818:Animals; D001932:Brain Neoplasms / Q000276:immunology / Q000601:surgery / Q000628:therapy*; D002415:Cats; D003602:Cytotoxicity, Immunologic; D005910:Glioma / Q000276:immunology / Q000601:surgery / Q000628:therapy*; D007167:Immunotherapy / Q000379:methods*; D007276:Injections, Intraventricular; D008196:Lymph / Q000276:immunology*; D009360:Neoplastic Cells, Circulating; D013238:Stereotaxic Techniques; D013897:Thoracic Duct