Biopharmaceutical study of insulin suppositories.
The possibility of insulin administration in suppository dosage form was studied, using different carriers. Highly significantly insulin absorption from the rabbit rectum was obtained by inserting insulin suppositories containing Brij 58 as absorption-promoting surfactant.
D000818:Animals; D001702:Biopharmaceutics; D001786:Blood Glucose / Q000378:metabolism; D007275:Injections, Intravenous; D007328:Insulin / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D007408:Intestinal Absorption / Q000187:drug effects; D014677:Pharmaceutical Vehicles; D011817:Rabbits; D013488:Suppositories; D013501:Surface-Active Agents / Q000494:pharmacology
D001786:Blood Glucose; D007328:Insulin; D014677:Pharmaceutical Vehicles; D013488:Suppositories; D013501:Surface-Active Agents