Terminal degeneration demonstrated by the Fink-Heimer method following lateral ventricular injection of 6-hydroxydopamine.
Degenerating terminals were mapped by the Fink-Heimer method after lateral or fourth ventricular administration of 6-hydroxydopamine (60OHDA). This method marks dopaminergic terminals and has the advantage that noradrenergic terminals are not stained. Fink-Heimer stained degeneratig terminals were seen bilaterally in specific patterns in many nuclei known to have a dopaminergic innervation: neostriatum, nucleus accumbens, olfactory tubercle, the dorsolateral and ventral parts of the bed nucleus of the stria terminalis, laterla septal nucleus, amygdala, and layers II-III of anterior cingulate cortex. Detailed maps are provided of the dopaminergic innervation in the bed nucleus of the atria terminalis in relatin to the cytoarchitectural subdivisions of this nucleus. A Fink-Heimer stained field was discovered in the lateral parabrachial nucleus, suggesting the presence of a previously unreported dopaminergic innervation of this nucleus. It was also noted that nonspecific degeneration near the injection site was much worse after lateral ventricle than after fourth ventricle injection.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D003342:Corpus Striatum / Q000187:drug effects; D006179:Gyrus Cinguli / Q000187:drug effects; D006652:Histological Techniques; D006892:Hydroxydopamines / Q000494:pharmacology*; D007276:Injections, Intraventricular; D009410:Nerve Degeneration / Q000187:drug effects*; D009434:Neural Pathways / Q000187:drug effects; D009714:Nucleus Accumbens / Q000187:drug effects; D009830:Olfactory Bulb / Q000187:drug effects; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D012686:Septal Nuclei / Q000187:drug effects
D006892:Hydroxydopamines; D011954:Receptors, Dopamine