[Use of the D7 strain of S. cerevisiae in the determination of environmental genetic risk. 2. Genetic effects of procarbazine].
Procarbazine was tested in vitro without and with S-10 fraction from mice liver (microsomal assay) using Saccharomyces cerevisiae strain D7, Salmonella typhimurium (strains TA 98, TA 100, TA 1535) and in vivo in Swiss albino mice (host mediated assay) using D7. Procarbazine without S-10 fraction was highly toxic and induced mitotic cross-over, gene conversion, and reverse mutation in D7. It had a toxic effect on all the Salmonella strains, but it did not induce any reverse mutations of the histidine mutants. In host-mediated assay using Saccharomyces, there was no genetic effect found in the indicator organism.
D000818:Animals; D001711:Biotransformation; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004787:Environmental Pollution; D005796:Genes / Q000187:drug effects*; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D008938:Mitosis / Q000187:drug effects; D009152:Mutagenicity Tests / Q000379:methods; D009154:Mutation; D011344:Procarbazine / Q000494:pharmacology*; D012306:Risk; D012441:Saccharomyces cerevisiae / Q000187:drug effects*; D012486:Salmonella typhimurium / Q000187:drug effects
D011344:Procarbazine
L'impiego del ceppo D7 di S. cerevisiae nella determinazione del rischio genetico ambientale. 2. Effetti genetici della procarbazina.