title: Unique temperature-sensitive nutritional requirements of bacteremic Escherichia coli isolates.
abstract: Of 50 strains of Escherichia coli isolated from blood cultures of bacteremic patients, 14 (28%) were unable to grow on minimal medium at 42 degrees C, compared to only 2 of 50 nonbacteremic strains. In 7 of the 14 bacteremic strains, growth at 42 degrees C was restored by adding nicotinic acid. These unique temperature-sensitive auxotrophic patterns warrant evaluation as a marker correlating with clinical pathogenicity in E. coli.
mesh_terms: D003470:Culture Media; D004926:Escherichia coli / Q000502:physiology*; D004927:Escherichia coli Infections / Q000382:microbiology*; D008715:Methionine / Q000494:pharmacology; D009525:Niacin; D009539:Nicotinic Acids / Q000494:pharmacology*; D018805:Sepsis / Q000382:microbiology*; D013696:Temperature
chemical_list: D003470:Culture Media; D009539:Nicotinic Acids; D009525:Niacin; D008715:Methionine