Binding of antimalarial drugs to hemozoin from Plasmodium berghei.
Chloroquine, quinacrine and mefloquine bind to Plasmodium berghei hemozoin, hemin, hemi, protoporphyrin IX and protease digested methemoglobin. This binding may be the basis for drug accumulation and action in the parasite.
D000818:Animals; D000962:Antimalarials / Q000378:metabolism*; D002738:Chloroquine / Q000378:metabolism; D006418:Heme / Q000378:metabolism; D006420:Hemeproteins / Q000378:metabolism; D015767:Mefloquine; D008706:Methemoglobin / Q000378:metabolism; D010860:Pigments, Biological / Q000378:metabolism; D010880:Piperidines / Q000378:metabolism; D010962:Plasmodium berghei / Q000378:metabolism*; D011485:Protein Binding; D011524:Protoporphyrins / Q000378:metabolism; D011796:Quinacrine / Q000378:metabolism; D011804:Quinolines / Q000378:metabolism; D013053:Spectrophotometry
D000962:Antimalarials; D006420:Hemeproteins; D010860:Pigments, Biological; D010880:Piperidines; D011524:Protoporphyrins; D011804:Quinolines; C020753:hemozoin; D006418:Heme; D002738:Chloroquine; D008706:Methemoglobin; D011796:Quinacrine; D015767:Mefloquine