Endogenous Aspergillus endophthalmitis in drug abusers.
One of two cases of endogenous Aspergillus endophthalmitis in abusers of intravenously administered drugs was treated successfully by subtotal pars plana vitrectomy; amphotericin B administered by intravitreal, periocular, and systemic routes; and flucytosine administered systemically. Aspergillus sp should be considered a possible pathogenic organism in drug abusers with endogenous endophthalmitis. An aggressive diagnostic and therapeutic approach may result in preservation of useful vision.
D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage; D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D009877:Endophthalmitis / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D008828:Microbiological Techniques; D019966:Substance-Related Disorders / Q000150:complications*; D014792:Visual Acuity; D014822:Vitreous Body / Q000601:surgery
D000666:Amphotericin B; D005437:Flucytosine