A double blind trial of extra-amniotic oestriol and prostaglandin F2 alpha gels in cervical ripening.
Forty nulliparous patients with Bishop score of 3 or less were given 15 mg oestriol gel, 10 mg PGF2 alpha gel or gel alone via the extra-amniotic route. Both the oestriol and prostaglandin treated patients had a significant increase in Bishop score and a significant reduction in induction-delivery interval compared to controls. Oestriol gel had significantly less stimulatory effect on uterine activity than prostaglandin gel, indicating a possible local action.
D002584:Cervix Uteri / Q000187:drug effects*; D002986:Clinical Trials as Topic; D036861:Delivery, Obstetric; D004311:Double-Blind Method; D004964:Estriol / Q000627:therapeutic use*; D005260:Female; D005782:Gels; D006801:Humans; D007231:Infant, Newborn; D007751:Labor, Induced / Q000379:methods*; D011247:Pregnancy; D011460:Prostaglandins F / Q000627:therapeutic use*
D005782:Gels; D011460:Prostaglandins F; D004964:Estriol