title: Comparison of sulphadiazine-trimethoprim and sulphamethoxazole-trimethoprim in the treatment of acute respiratory tract infections. Randomized double-blind trial.
abstract: The combination of sulphadiazine 225 mg (SD) and trimethoprim 75 mg (TMP) was compared with the combination of sulphamethoxazole 400 mg (SM) and trimethoprim 80 mg (TMP) in the treatment of acute respiratory tract infection using a randomized double-blind clinical trial. The dose of both preparations was two tablets twice daily for 7-14 days. The patients were 200 conscripts hospitalized for an acute respiratory infection warranting antibacterial treatment. The most frequent diagnoses were pneumonia, bronchitis and tonsillitis. The combination SD/TMP was statistically significantly (p less than 0.001) superior to the combination of SM/TMP regarding overall efficacy of all indications. Especially pneumonia and bronchitis responded more favourably to SD/TMP than to SM/TMP. The duration of fever was also shorter (p less than 0.001) with SD/TMP than with SM/TMP. The occurrence of side effects was 2% in both treatment groups.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations; D005334:Fever; D006801:Humans; D007902:Length of Stay; D011897:Random Allocation; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D013411:Sulfadiazine / Q000009:adverse effects / Q000627:therapeutic use*; D013420:Sulfamethoxazole / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors; D014295:Trimethoprim / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D013411:Sulfadiazine; D014295:Trimethoprim; D013420:Sulfamethoxazole