[Relative clinical biological availability of a combination of trimethoprim-sulfamethoxazole in fasting children and after a meal].
Lidaprim, a bactericidal chemotherapeutical agent, was administered to 10 patients in a children's hospital, in the form of an oval suspension for children. The initial dosage was given on an empty stomach, the second after a standard meal. The concentrations of the chemotherapeutical agents in the plasma and the urine were chemically analysed. The bio-availability of the preparation was very good. A standard meal, taken just before dosage, led to a delay in absorption both for Trimethoprim and Sulfametrol. In the period under surveillance, 0-12 hours after administration, an absorption loss could be calculated from the plasma and urine levels in the case of both Trimethoprim and Sulfametrol. In spite of this effect, adequate plasma and urine levels with a bactericidal action, were achieved with the usual dosage. The clinical success and compatibility of the preparation were good in every single case.
D000284:Administration, Oral; D000293:Adolescent; D001682:Biological Availability; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004435:Eating; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000378:metabolism*; D013535:Suspensions; D014295:Trimethoprim / Q000008:administration & dosage / Q000378:metabolism*
D004338:Drug Combinations; D013535:Suspensions; D014295:Trimethoprim; D013420:Sulfamethoxazole
Relative klinische Bioverfügbarkeit der Kombination Trimethoprim-Sulfametrol, nüchtern und nach einer Mahlzeit, bei Kindern.