Crossover comparison of benoxaprofen and naproxen in osteoarthritis.
A total of 30 patients participated in a double-blind crossover trial to compare the efficacy and safety of benoxaprofen with naproxen in the treatment of osteoarthritis. Benoxaprofen, 600 mg administered once daily, was as effective as naproxen, 250 mg administered twice daily. Adverse reactions were mostly mild to moderate in severity and the incidence of the reactions was similar for the 2 study drugs. The advantage of the once-a-day dose regimen of benoxaprofen is discussed.
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D001583:Benzoxazoles / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000009:adverse effects / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000188:drug therapy*; D010349:Patient Compliance; D011422:Propionates / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D012459:Salicylates / Q000097:blood; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D001583:Benzoxazoles; D011422:Propionates; D012459:Salicylates; C011677:benoxaprofen; D009288:Naproxen