Cytoskeletal and muscle-like elements in cochlear hair cells.
Monospecific antibodies to actin and to tubulin were used as immunofluorescent probes to evaluate the distribution of microtubules and actin filaments in the organ of Corti in mouse and guinea pig. The results indicate that in cochlear receptor cells actin and actin filaments as well as tubulin and microtubules are integral cytoskeletal elements. The presence of actin suggests a possible contractile mechanism within the sensory cilia whereas tubulin is thought to play an important role in the stability of sensory cells. Both proteins are discussed to form structural elements required for the mechano-chemical coupling in hearing.
D000199:Actins / Q000032:analysis*; D000818:Animals; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000032:analysis*; D051379:Mice; D009925:Organ of Corti / Q000276:immunology; D051381:Rats; D014404:Tubulin / Q000032:analysis*
D000199:Actins; D014404:Tubulin