[Nutritive effects of an intestinal alpha-glucosidases-inhibition in rats (author's transl)].
In a balance trial the effect of different dietary doses of the alpha-glucosidases-inhibitor Bay g5421 on nutrient digestibility and N-balance was tested with rats. The supplements of 30, 90 and 210 mg Bay g5421 per kg of feed reduced the digestibility of starch plus sucrose by 2, 16 and 27%. The protein digestibility decreased by 5, 14 and 19%. This shows that for the organism 3, 13 and 24% less digestible energy was available. The excretion of the urinary energy was not influenced in the different groups. The elevated fecal N excretion with the supplements of 30 and 90 mg Bay g5421 per kg of feed was compensated by a lower N-excretion in the urine. At the dose level of 210 mg Bay g5421 N balance was diminished.
D020909:Acarbose; D000284:Administration, Oral; D000818:Animals; D004063:Digestion / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism / Q000187:drug effects; D005959:Glucosidases / Q000037:antagonists & inhibitors*; D065089:Glycoside Hydrolase Inhibitors; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D009844:Oligosaccharides / Q000008:administration & dosage*; D051381:Rats; D014312:Trisaccharides / Q000008:administration & dosage*
D065089:Glycoside Hydrolase Inhibitors; D009844:Oligosaccharides; D014312:Trisaccharides; D005959:Glucosidases; D009584:Nitrogen; D020909:Acarbose
Nutritive Auswirkungen einer intestinalen alpha-Glucosidasen-Hemmung bei Ratten.