Combination of timolol maleate, hydrochlorothiazide and amiloride hydrochloride in the treatment of hypertension: A multicentre trial.
The effect of a single dose of timolol, hydrochlorothiazide and amiloride in fixed combination (Moducren; MSD) in patients with mild to moderate essential hypertension was tested in an open study during 1978. Ninety-one and a half per cent of the patients studied responded with a fall in diastolic blood pressure of 20 mmHg or more. In 72% a single daily tablet of the combined preparation was sufficient to achieve and maintain control. Patient compliance was excellent and adverse reactions were generally of a minor nature.
D000328:Adult; D000368:Aged; D000584:Amiloride / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008298:Maleates / Q000627:therapeutic use; D008875:Middle Aged; D010919:Placebos; D011188:Potassium / Q000097:blood; D011412:Propanolamines / Q000627:therapeutic use*; D011719:Pyrazines / Q000627:therapeutic use*; D013999:Timolol / Q000009:adverse effects / Q000627:therapeutic use*; D014503:Urate Oxidase / Q000097:blood
D004338:Drug Combinations; D008298:Maleates; D010919:Placebos; D011412:Propanolamines; D011719:Pyrazines; D006852:Hydrochlorothiazide; D000584:Amiloride; D013999:Timolol; D014503:Urate Oxidase; D011188:Potassium