Reed-Sternberg cells in Hodgkin's disease contain fibronectin.
Reed-Sternberg cells in the lymph nodes from five patients with Hodgkin's disease were studied. Indirect immunofluorescence on fixed sections with a monospecific anti-serum to fibronectin revealed abundant cytoplasmic fibronectin in approximately 90% of the Reed-Sternberg cells. In addition, the cells were shown by immunofluorescence to contain polyclonal IgG; however, factor VIII antigen, albumin, fibrinogen, alpha-2-macroglobulin, anti-thrombin III, and ceruloplasmin were not present. The abundant cytoplasmic fibronectin suggests that Reed-Sternberg cells are derived from tissue macrophages.
D000818:Animals; D005353:Fibronectins / Q000276:immunology / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D006689:Hodgkin Disease / Q000378:metabolism*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000378:metabolism; D007951:Leukemia, Myeloid / Q000276:immunology; D008198:Lymph Nodes / Q000378:metabolism*; D008223:Lymphoma / Q000378:metabolism; D011817:Rabbits
D005353:Fibronectins