title: [Odontostomatogenic focal disease; embryologic and clinical causes of autoimmune pathogenesis].
abstract: The autoimmune pathogenesis of the focal odontostomatogenous disease is investigated and emphasis is laid on the different keys of interpretation: at embryologic, clinic and immunologic level. A special attention is paid to the primary meaning of structured or non structured lymphoid tissue of oropharynx, on account of embryologic identity with thymus and bursa of Fabricius, differentiating into sectors of ecto-entodermic stratification. The clinical evidence of the bursa-equivalent significance of Waldeyer ring, appears to lie in the ascertainment of the tonsillar atrophy in course of agammaglobulinaemia of Bruton type. The active chronic irritant phlogistic stimulus in a primary structure could excite the normal production of intolerant clones, so as to exceed the normal physiological homeostasis (giving rise to the autoimmune disease), or alter the mosiac self, inducing a production of autoantibodies.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001323:Autoantibodies / Q000096:biosynthesis; D001327:Autoimmune Diseases / Q000196:embryology* / Q000209:etiology / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D002060:Bursa of Fabricius / Q000196:embryology / Q000276:immunology; D005491:Focal Infection, Dental / Q000196:embryology* / Q000209:etiology / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D008221:Lymphoid Tissue / Q000196:embryology / Q000276:immunology; D009960:Oropharynx / Q000196:embryology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000196:embryology / Q000276:immunology
chemical_list: D001323:Autoantibodies
vernacular_title: La malattia focale odontostomatogena; motivazioni embriologiche e cliniche della patogenesi autoimmune.