Reduced umbilical and placental vascular prostacyclin in severe pre-eclampsia.
Prostacyclin production was significantly depressed in foetal and placental vascular tissues from five patients with severe pre-eclampsia in comparison to vascular tissues from women with uncomplicated pregnancy. Such an abnormality may be responsible for a reduced blood flow and defective fetal nutrition thus playing a major role in the pathogenesis of this syndrome.
D000293:Adolescent; D000328:Adult; D011464:Epoprostenol / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D010920:Placenta / Q000098:blood supply*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D011453:Prostaglandins / Q000096:biosynthesis*; D014469:Umbilical Arteries / Q000378:metabolism*; D014680:Veins / Q000378:metabolism
D011453:Prostaglandins; D011464:Epoprostenol