title: Night driving (mesopic) visual acuity in sober male alcoholics with and without liver disease.
abstract: Night driving (mesopic) visual acuity and recovery after dazzle has been reported to be reduced in patients with liver disease. Mesopic visual acuity and dazzle recovery were evaluated in 32 patients with alcoholic cirrhosis, 29 alcoholics without liver disease, and 27 age-matched normal controls. All subjects were sober for at least 7 days prior to visual testing, a mean sobriety period of 22 and 39 weeks in alcoholics and cirrhotics, respectively. Serum vitamin A levels and/or dark adaptation were normal in all. Mean best decimal acuities were not significantly different among the groups: alcoholic cirrhotics, 0.32 +/- 0.02; alcoholics, 0.32 +/- 0.02; and normals 0.33 +/- 0.03 at 2 min. Although cirrhotics had significantly higher SGOT and lower albumin levels than alcoholics, mesopic acuity did not relate to liver blood tests. Decimal acuity following a dazzle stimulus was not significantly worse in cirrhotics and alcoholics compared to normals. Sober patients with alcoholic cirrhosis or a history of alcoholism have no evidence of a static mesopic visual defect and therefore may not have impaired night driving vision.
mesh_terms: D000437:Alcoholism / Q000503:physiopathology*; D001334:Automobile Driving; D003623:Dark Adaptation; D003624:Darkness; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000503:physiopathology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D014792:Visual Acuity / Q000187:drug effects*; D014801:Vitamin A / Q000097:blood
chemical_list: D014801:Vitamin A