title: [Granulomatous allergic reaction of the delayed type to surfen].
abstract: In the last five years, a distinct increase of allergic reactions to surfen, a constituent of various insulin preparations, was observed. The allergic reactions were tuberculoid granulomas of the delayed type (type IV of Gell and Coombs). Intracutaneous tests with surfen or surfen-containing insulin preparations confirmed the diagnosis. Dermal infiltrates and mild erythema developed 24 to 96 hours after the injection of insulin. In some patients a post-inflammatory pigmentation was noted. Histological examination of the lesions and the intracutaneous test sites revealed a granulomatous inflammation without signs of foreign body reaction. At present, the cause of the increased incidence of allergic reactions to surfen remains hypothetical.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced* / Q000473:pathology; D007328:Insulin / Q000009:adverse effects; D014375:Tuberculoma / Q000139:chemically induced* / Q000473:pathology; D014508:Urea / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D007328:Insulin; C010850:aminoquinuride; D014508:Urea
vernacular_title: Granulomatöse allergische Reaktion vom verzögerten Typ auf Surfen.