Treatment of murine cryptococcosis with minocycline and amphotericin B.
Minocycline has an additive anticryptococcal effect when combined with amphotericin B in vitro, and the combination lowers tissue counts of fungi. However, minocycline offers no survival benefit to amphotericin B therapy in murine cryptococcosis.
D000666:Amphotericin B / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D003453:Cryptococcosis / Q000188:drug therapy* / Q000401:mortality; D003455:Cryptococcus neoformans / Q000187:drug effects; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D005260:Female; D008297:Male; D051379:Mice; D008911:Minocycline / Q000008:administration & dosage* / Q000494:pharmacology; D013754:Tetracyclines / Q000008:administration & dosage*
D013754:Tetracyclines; D000666:Amphotericin B; D008911:Minocycline