Influence of lipidic plant extracts on cells kinetics during carrageenin-induced inflammation of guinea pig palatal mucosa.
It has been shown that guinea pigs treated during 60 days with vegetal insaponified fractions presented a stabilization of the vessels volumetric density during the 4 days following a carrageenan injection in the palatal mucosa when compared with the vascular increase observed in non-treated animals. This inhibition of the inflammatory vascular neoformation influences the cells kinetics during the carrageenan induced inflammation of the palatal mucosa. The cellular volume fractions were calculated by a stereologic technique based on a morphometric point counting procedure described by Weibel (1969). The principal result consists in a general decrease of the inflammatory cells volume densities, specially concerning the polymorphonuclear leukocytes. This phenomenon must be related to the vascular volume fraction stabilization during the inflammatory process and could explain the drug activity on inflammatory states.
D000818:Animals; D001808:Blood Vessels / Q000473:pathology; D002351:Carrageenan / Q000494:pharmacology; D006168:Guinea Pigs; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology*; D008055:Lipids / Q000494:pharmacology*; D008297:Male; D009061:Mouth Mucosa / Q000187:drug effects; D010159:Palate; D010936:Plant Extracts / Q000494:pharmacology*; D013997:Time Factors
D008055:Lipids; D010936:Plant Extracts; D002351:Carrageenan