title: Synergistic denaturant therapy--a general strategy for treatment of solid malignancies.
abstract: "Synergistic denaturant therapy" is defined as the acute disruption of tumor cell structure by concurrent application of "denaturant" modalities such as hyperthermia, tumor-specific acidification, hypoenergia, ischemia, sulphydryl blockade, free-radical generation, detergents, and chemical denaturants (e.g. DMSO). Possible techniques for effective and tumor-specific clinical application of these modalities are discussed, and experimental investigations of their use in cancer therapy, alone or in synergistic combinations, are cited. Various of these modalities may also be used to potentiate the efficacy and specificity of traditional anti-mitotic therapies. Numerous therapeutic advantages are offered by a "synergistic denaturant" approach.
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D005334:Fever; D005609:Free Radicals; D006358:Hot Temperature / Q000627:therapeutic use*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007511:Ischemia / Q000503:physiopathology; D008938:Mitosis / Q000187:drug effects; D009369:Neoplasms / Q000503:physiopathology / Q000628:therapy*; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000503:physiopathology / Q000628:therapy; D013439:Sulfhydryl Reagents / Q000627:therapeutic use
chemical_list: D005609:Free Radicals; D013439:Sulfhydryl Reagents; D000255:Adenosine Triphosphate