[Clinical findings, pathogenesis and treatment of Bartter's syndrome (author's transl)].
In three children Bartter's syndrome was diagnosed on the basis of the typical laboratory findings and the characteristic histological changes of the kidney. Apart from the description of three cases especially the latest pathogenic findings are represented because of their important therapeutic consequences. In one of the patients the therapeutic effect of the prostaglandin synthetase inhibitor Indomethazin was statistically proved in a balance study performed under inpatient conditions and so it was indirectly proved that the prostaglandines play an essential role in the pathogenesis of Bartter's syndrome. The patients have now received Indomethazin for a period of 11 months up to two and a half years with the result of an impressive improvement of the clinical symptoms and an unequivocal increase of the serum potassium. The fact that despite of normal renin and aldosterone levels there was no complete normalization of the serum potassium level indicates that in addition of prostaglandines probably a superior mechanism plays a part in the origin Bartter's syndrome.
D000450:Aldosterone / Q000097:blood; D001477:Bartter Syndrome / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D002648:Child; D003937:Diagnosis, Differential; D004573:Electrolytes / Q000097:blood; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000175:diagnosis*; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D012083:Renin / Q000097:blood
D004573:Electrolytes; D000450:Aldosterone; D012083:Renin; D007213:Indomethacin
Klinik, Pathogenese und Therapie des Bartter-Syndroms.