Familial insulin resistance with pineal hyperplasia: metabolic studies and effect of hypophysectomy.
Mendenhall's syndrome comprises insulin-resistant diabetes, pineal hyperplasia, and various somatic anomalies. A boy with this condition now aged 12 years is reported; a similarly affected sibling died aged 7.8 years. Hypophysectomy has been of short-term benefit, but the problems of insulin resistance persist. On the basis of monocyte-binding studies it seems likely that in this condition there is an inherited deficiency of insulin receptors.
D002648:Child; D003920:Diabetes Mellitus / Q000235:genetics* / Q000601:surgery; D006801:Humans; D006965:Hyperplasia; D007016:Hypophysectomy; D007328:Insulin / Q000627:therapeutic use; D007333:Insulin Resistance; D008297:Male; D010870:Pineal Gland / Q000473:pathology*; D013577:Syndrome
D007328:Insulin