Brief communication: possible X-linked anencephaly and spina bifida--report of a kindred.
Causal heterogeneity of anencephaly and spina bifida has been demonstrated; in rare families the neural tube defect may be caused by a single gene. We report a family in which four cases of anencephaly or spina bifida may represent X-linked inheritance.
D000015:Abnormalities, Multiple / Q000235:genetics*; D000328:Adult; D000757:Anencephaly / Q000235:genetics*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010375:Pedigree; D012730:Sex Chromosomes; D016136:Spina Bifida Occulta / Q000235:genetics*; D014960:X Chromosome