[Interactions between amphotericin B and hydroxytetracycline].
By means of the Warburg assay (manometric technique), investigations were performed to elucidate interactions between amphotericin B, a polyene antifungal antibiotic, and hydroxytetracycline. Those two compounds were combined in clinical therapy. On resting yeasts and bacteria, interactions could be ruled out. On the contrary, on both types of microbes a significant increase in antimicrobial actions could be seen in the presence of the second substance. The antimycetic activity of amphotericin B was significantly increased in the presence of hydroxytetracycline (in five-fold concentrations). The antibacterial activity of hydroxytetracycline was significantly higher in the presence of amphotericin B (same concentrations). The clinical implication of these results is briefly discussed.
D000666:Amphotericin B / Q000627:therapeutic use*; D002176:Candida albicans / Q000187:drug effects; D004359:Drug Therapy, Combination; D006801:Humans; D010118:Oxytetracycline / Q000627:therapeutic use*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D000666:Amphotericin B; D010118:Oxytetracycline
Wechselwirkungen zwischen Amphotericin B und Hydroxytetracyclin.