Phenotypic resistance to miconazole and amphotericin B in Candida albicans.
Phenotypic resistance to both amphotericin B and miconazole develops in stationary phase cultures of Candida albicans and this resistance lies in changes in the cell wall. Study of the effects of growth conditions, treatment with SH-reactive agents and treatment with enzymes indicates that the nature of the changes leading to resistance must be different for the two drugs.
D000666:Amphotericin B / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D002453:Cell Cycle; D002473:Cell Wall / Q000187:drug effects; D004352:Drug Resistance, Microbial; D004798:Enzymes / Q000378:metabolism; D007093:Imidazoles / Q000494:pharmacology*; D008825:Miconazole / Q000494:pharmacology*; D010100:Oxygen; D013438:Sulfhydryl Compounds / Q000494:pharmacology
D004798:Enzymes; D007093:Imidazoles; D013438:Sulfhydryl Compounds; D008825:Miconazole; D000666:Amphotericin B; D010100:Oxygen