title: Mutagenicity of dichloroacetate, an ingredient of some formulations of pangamic acid (trade-named "vitamin B15").
abstract: Dichloroacetate demonstrates low grade mutagenicity in the Ames Salmonella/mammaltan microsome mutagenicity test. This evidence of probable carcinogenicity must be considered in any proposed use of dichloroacetate or of preparations of pangamic acid (trade-named "vitamin B15") CONTAINING DICHLOROACETATE.
mesh_terms: D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D001140:Aroclors / Q000494:pharmacology; D002125:Calcium Gluconate; D002273:Carcinogens; D003999:Dichloroacetic Acid / Q000494:pharmacology*; D008862:Microsomes, Liver; D009153:Mutagens; D034442:N-substituted Glycines; D011437:Propylamines; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics; D014803:Vitamin B Complex / Q000009:adverse effects*
chemical_list: D000085:Acetates; D001140:Aroclors; D002273:Carcinogens; D009153:Mutagens; D034442:N-substituted Glycines; D011437:Propylamines; D014803:Vitamin B Complex; D003999:Dichloroacetic Acid; C105565:pangamic acid; D002125:Calcium Gluconate