title: The influence of vitamin E on capsule formation and contracture around silicone implants.
abstract: An attempt was made to determine if the tissue response to surgical trauma and foreign body stimulus (silicone implants) could be altered using vitamin E in rats. The animals were divided into four groups: Group A served as controls, Group B were treated by intramuscular vitamin E, Group C were treated topically with vitamin E around the prosthesis, and Group D were treated topically with croton oil around the prosthesis. The animals in each group were killed at 2 week, 1 month, and 3 months intervals. The intraprosthetic pressure in each prosthesis was recorded using a strain gauge transducer. The capsules were then removed and examined histologically using a light microscope and the thickness of pseudocapsules was measured with an ocular micrometer. In Group B significantly thinner pseudocapsules were observed at 2 weeks, but there was no comparable difference either in thickness or degree of contracture (as measured by intraprosthetic pressures) between Groups A and B at 2 months and 3 months. In Group C, the pseudocapsules were significantly thicker at all tested periods and showed noticeable contracture at 3 months. In group D the pseudocapsules were thickest and cellular infiltrate more marked than in the other groups.
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001415:Back; D001699:Biometry; D003286:Contracture / Q000453:epidemiology; D003436:Croton Oil / Q000008:administration & dosage; D005549:Foreign-Body Reaction / Q000473:pathology / Q000517:prevention & control; D007273:Injections, Intramuscular; D009132:Muscles / Q000473:pathology; D011312:Pressure; D019736:Prostheses and Implants; D051381:Rats; D012826:Silicone Elastomers / Q000633:toxicity*; D012867:Skin / Q000473:pathology; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D012826:Silicone Elastomers; D014810:Vitamin E; D003436:Croton Oil