Effect of urokinase on corneal endothelium.
Urokinase in concentrations ranging from 1,000 to 5,000 units/mL was used to perfuse the corneal endothelium of rabbits for three hours in the specular microscope. No notable corneal swelling was noted, and the corneal endothelium appeared normal when observed with scanning electron microscopy.
D000818:Animals; D003315:Cornea / Q000187:drug effects*; D003316:Corneal Diseases / Q000209:etiology; D004487:Edema / Q000209:etiology; D010450:Endopeptidases / Q000633:toxicity*; D004727:Endothelium / Q000166:cytology / Q000187:drug effects; D008853:Microscopy / Q000379:methods; D008855:Microscopy, Electron, Scanning; D010477:Perfusion; D011817:Rabbits; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000633:toxicity*
D010450:Endopeptidases; D014568:Urokinase-Type Plasminogen Activator