Demonstration of 2n spermatids in carriers of the "sex reversed" factor in the mouse by Feulgen cytophotometry.
The "Sex Reversed" factor (SXY) leads to development of XX males. The condition is transmitted by XY-Sxr males. The testes of XY-Sxr carriers are characterized by patches of defective spermatogenesis with meiotic failure and appearance of extraordinary large spermatids. In the present study DNA content of the large spermatids is determined by Feulgen DNA measurement using a scanning cytophotometer. The large spermatids in XY-Sxr testes are shown to be 2n.
D000818:Animals; D002869:Chromosome Aberrations / Q000235:genetics* / Q000378:metabolism; D025063:Chromosome Disorders; D003584:Cytological Techniques; D004247:DNA / Q000032:analysis*; D012734:Disorders of Sex Development / Q000235:genetics* / Q000378:metabolism; D006579:Heterozygote; D008297:Male; D051379:Mice; D013050:Spectrometry, Fluorescence; D013087:Spermatids / Q000032:analysis*; D013091:Spermatogenesis; D013094:Spermatozoa / Q000032:analysis*
D004247:DNA