Protective effect of arginine, leucine and preinjection of insulin on glutamate neurotoxicity in mice.
The simultaneous intubation of 10-day-old mice with either 2.28 g/kg body weight arginine hydrochloride or 0.2 g/kg b.wt. leucine significantly reduced the number of necrotic neurons in the arcuate nucleus (AN) of the hypothalamus resulting from 2 g/kg b. wt. monosodium L-gultamate (MSG). The prior injection of 0.02 units per capita of insulin suppressed the MSG-induced lesions to an even great extent. These findings are believed to form a basis for the ineffectiveness of dietary MSG in producing hypothalamic lesions.
D000284:Administration, Oral; D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D005971:Glutamates / Q000633:toxicity*; D007031:Hypothalamus / Q000187:drug effects*; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage* / Q000494:pharmacology; D007930:Leucine / Q000494:pharmacology*; D051379:Mice; D009821:Oils / Q000494:pharmacology; D012970:Sodium Glutamate / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*
D005971:Glutamates; D007328:Insulin; D009821:Oils; D001120:Arginine; D007930:Leucine; D005947:Glucose; D012970:Sodium Glutamate