Local antifertility effect of luteinizing hormone-releasing hormone (LRH) in the rat: mechanism of action.
The administration of luteinizing hormone-releasing hormone (LRH) into one horn of the uterus at 0900 h on D5 of pregnancy produces a 96% reduction in the number of zona-encased blastocysts recovered between 0915 and 1300 h on D5. The number of blastocysts recovered within this time period also decreased; only one blastocyst was recovered from the LRH-treated horn at 1300 h while 26 were flushed from the horns injected with saline. The results of this study suggest that LRH causes a premature disassociation of the zona from the blasocyst allowing early adherence to the uterine wall. This asynchronous attachment results in disruption of the ensuing pregnancy.
D000818:Animals; D001755:Blastocyst / Q000187:drug effects*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D010063:Ovum / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D013997:Time Factors; D014599:Uterus / Q000187:drug effects; D015044:Zona Pellucida / Q000187:drug effects*
D007987:Gonadotropin-Releasing Hormone