Interaction of minoxidil and captopril in the treatment of refractory hypertension.
A case of severe hypertension resistant to multiple drug therapy was controlled with minoxidil, captopril, and propranolol hydrochloride after treatment with these drugs alone or in other combinations had failed. Hyperreninemic hypoaldosteronism with hyperkalemia and acidosis developed after captopril administration was started.
D000138:Acidosis / Q000139:chemically induced; D000293:Adolescent; D000450:Aldosterone / Q000097:blood; D002216:Captopril / Q000009:adverse effects / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood; D004347:Drug Interactions; D005260:Female; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D011392:Proline / Q000031:analogs & derivatives*; D011433:Propranolol / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use*; D012083:Renin / Q000097:blood; D013997:Time Factors
D011743:Pyrimidines; D000450:Aldosterone; D011392:Proline; D002216:Captopril; D011433:Propranolol; D003404:Creatinine; D012083:Renin