title: Changes in the contractile proteins of skeletal muscles induced by steroid myopathy.
abstract: The effect of chronic dexamethasone treatment was investigated on the myofibriller proteins of slow (soleus) and fast (semimembranous) muscles. The relative quantities of actin, protein C and protein M increased, while the myosin, troponin inhibitor and calcium binding components showed a relative decrease in both muscle types. The amount of troponin regulatory component and alpha-actinin decreased only in the fast muscle, while tropomyosin decreased significantly in the slow muscle. The isoenzyme pattern of fast muscle myosin was altered as a consequence of decreased myosin (LC-3 subunit.
mesh_terms: D000818:Animals; D003907:Dexamethasone / Q000009:adverse effects*; D005260:Female; D008297:Male; D009124:Muscle Proteins / Q000032:analysis* / Q000378:metabolism; D009135:Muscular Diseases / Q000139:chemically induced* / Q000378:metabolism; D011480:Protease Inhibitors; D011817:Rabbits
chemical_list: D009124:Muscle Proteins; D011480:Protease Inhibitors; D003907:Dexamethasone