[Intravenous glucose tolerance and islet cell function following pancreatic duct occlusion in rats (author's transl)].
Microsurgery, intraductal pancreatic occlusion by an Ethibloc bolus and intravenous glucose load in the rat enable investigations to be made into the feed-back relationships between occlusion-induced acinar atrophy and the response of the islet hormones insulin, glucagon, somatostatin, and glucose tolerance. Thirteen days after duct occlusion the latter is moderately delayed from 40-60 min, serum insulin is lowered, plasma somatostatin unchanged, and plasma glucagon moderately elevated, as compared with sham-operated control animals. It is suggested that the employed experimental conditions reveal an exo-endocrine pancreatic functional axis, but that the results obtained are not representative for states with an intact entero-insular axis.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D005246:Feedback; D007515:Islets of Langerhans / Q000502:physiology*; D008297:Male; D010183:Pancreatic Ducts / Q000502:physiology*; D051381:Rats
D001786:Blood Glucose
Intravenöse Glucosetoleranz und Inselfunktion nach Pankreasgang-Occlusion bei der Ratte.