Mesangial IgA nephropathy in pregnancy.
The clinical and renal biopsy findings in a group of 12 patients with mesangial IgA nephropathy who had 22 pregnancies are recorded. Seventeen pregnancies were successful. Hypertension was noted in 9 pregnancies and in 12, features of pre-eclamptic toxaemia developed. One patient had post-partum eclampsia. Proteinuria tended to increase during pregnancy and one patient developed nephrotic syndrome which resolved after delivery. Glomerular lesions in these women differed from those in non-pregnant patients with mesangial IgA nephropathy. Focal and segmental proliferative and hyalinosis-sclerosis changes were seen far more frequently than is usual in biopsies from patients with mesangial IgA nephropathy, suggesting that focal and segmental lesions develop during pregnancy.
D058186:Acute Kidney Injury / Q000209:etiology; D000293:Adolescent; D000328:Adult; D001706:Biopsy; D004461:Eclampsia / Q000150:complications; D005260:Female; D005328:Fetal Viability; D005340:Fibrinogen / Q000032:analysis; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D007070:Immunoglobulin A / Q000378:metabolism; D007668:Kidney / Q000473:pathology; D008750:Methyldopa / Q000627:therapeutic use; D009404:Nephrotic Syndrome / Q000209:etiology; D011225:Pre-Eclampsia / Q000150:complications; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology
D007070:Immunoglobulin A; D008750:Methyldopa; D005340:Fibrinogen