title: [Bronchoconstrictive side effects of timolol eye drops in patients with obstructive lung disease].
abstract: A double-blind crossover study in seven patients with glaucoma and obstructive lung disease revealed a considerable and significant bronchoconstrictive side effect on topically administered timolol maleat. Comparative treatment of these patients with an ophthalmic solution containing 3% carbachol did not yield a statistically significant bronchial reaction. However, the observation of serious lung function impairment in three patients suggests that carbachol is not a safe alternative for the treatment of glaucoma in patients with obstructive lung disease. Whenever a deterioration of airway obstruction occurs in elderly patients, or bronchial asthma becomes manifest late in life, topically administered beta-adrenergic-receptor blocking and cholinergic agents must be considered causative factors: optimal communication between all physicians caring for glaucoma patients is an essential prerequisite.
mesh_terms: D000368:Aged; D001986:Bronchial Spasm / Q000139:chemically induced*; D002217:Carbachol / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005901:Glaucoma / Q000188:drug therapy; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011412:Propanolamines / Q000009:adverse effects*; D012129:Respiratory Function Tests; D013999:Timolol / Q000009:adverse effects*
chemical_list: D009883:Ophthalmic Solutions; D011412:Propanolamines; D013999:Timolol; D002217:Carbachol
vernacular_title: Bronchokonstriktive Nebenwirkung von Timolol-Augentropfen bei Patienten mit obstruktiven Lungenerkrankungen.