Amoxapine and amitriptyline in the outpatient treatment of endogenous depression.
This double-blind investigation compared onset of action, efficacy, and safety of amoxapine and amitriptyline in 46 endogenously depressed outpatients. Statistical analysis demonstrated relatively few significant differences in improvement between the two groups. Most of the differences favored amoxapine, however, and on all measures there were clear trends favoring amoxapine for more rapid onset of action or greater overall efficacy or both.
D000293:Adolescent; D000328:Adult; D000553:Ambulatory Care; D000639:Amitriptyline / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000657:Amoxapine / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy*; D003989:Dibenzoxazepines / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
D003989:Dibenzoxazepines; D000639:Amitriptyline; D000657:Amoxapine