Cell-mediated immunity to lens proteins in rats.
The radiometric ear index technique was performed to investigate the ability of lens proteins to induce a cellular autoimmune response in rats. The immunization of inbred rats with autologous total lens crystallins caused activation of the cellular immune system that was predominantly directed to beta-crystallins; alpha-crystallins and gamma-crystallins were less active. The injection of autologous lens material into the ears of rats immunized with this material caused a significant infiltration of cells containing tritium-labelled thymidine.
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D003459:Crystallins / Q000276:immunology*; D005260:Female; D007111:Immunity, Cellular; D007158:Immunologic Techniques; D008297:Male; D051381:Rats
D003459:Crystallins