125I-fibrinogen uptake following phlebography of the leg. Comparison of ionic and nonionic contrast media.
The incidence of venous thrombosis diagnosed with the 125I-fibrinogen uptake test was investigated in a prospective, randomized, double-blind study with the patient serving as his own control, using an ionic contrast medium (methylglucamine iothalamate 280) in one leg and a nonionic medium (metrizamide) in the other. The incidence of thrombosis was significantly lower with metrizamide (7%) than with methylglucamine iothalamate (28.6%). The authors conclude that metrizamide is the contrast medium of choice for phlebography.
D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005340:Fibrinogen; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008536:Meglumine; D008793:Metrizamide; D008875:Middle Aged; D011446:Prospective Studies; D011877:Radionuclide Imaging; D013012:Sorbitol / Q000031:analogs & derivatives*; D013924:Thrombophlebitis / Q000175:diagnosis* / Q000000981:diagnostic imaging
D007457:Iodine Radioisotopes; D013012:Sorbitol; D008536:Meglumine; D005340:Fibrinogen; D008793:Metrizamide