Cyclophosphamide cardiotoxicity.
A 12-year-old boy with aplastic anemia developed severe but reversible cardiac failure after treatment with 200 mg/kg cyclophosphamide (4 x 50 mg/kg on four consecutive days) given as preparation for bone marrow grafting. This and previously reported cases demonstrate the possibility of cardiotoxicity after high doses of the drug.
D000741:Anemia, Aplastic / Q000188:drug therapy / Q000628:therapy; D016026:Bone Marrow Transplantation; D002648:Child; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006333:Heart Failure / Q000139:chemically induced*; D006801:Humans; D008297:Male; D014184:Transplantation, Homologous
D003520:Cyclophosphamide