Leukemic optic neuropathy.
The clinical course and ophthalmic manifestations of an eight year old child with acute undifferentiated leukemia and unilateral blindness secondary to leukemic optic nerve head infiltration are described. At autopsy the involved nerve head and peripapillary retina demonstrated massive leukemic cell infiltration and hemorrhagic necrosis. This manifestation of leukemia is quite uncommon and prognosis for life in such cases is poor with existing methods of therapy.
D001766:Blindness / Q000209:etiology; D016026:Bone Marrow Transplantation; D002648:Child; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000628:therapy; D008297:Male; D009901:Optic Nerve Diseases / Q000209:etiology*; D012160:Retina / Q000473:pathology; D012171:Retinal Vessels / Q000473:pathology; D014184:Transplantation, Homologous