title: Conditional-lethal deoxyribonucleic acid polymerase I mutant of Escherichia coli.
abstract: A new deoxyribonucleic acid polymerase I mutant of Escherichia coli was isolated among conditional lethal mutants. Deoxyribonucleic acid replication in the mutant ceased in 20 min after the temperature was raised to 43 degrees C, and reinitiated when cells were further incubated at this temperature.
mesh_terms: D004256:DNA Polymerase I / Q000235:genetics*; D004269:DNA, Bacterial / Q000096:biosynthesis; D004259:DNA-Directed DNA Polymerase / Q000235:genetics*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics*; D005804:Genes, Lethal; D009154:Mutation; D013696:Temperature
chemical_list: D004269:DNA, Bacterial; D004256:DNA Polymerase I; D004259:DNA-Directed DNA Polymerase