Hypertension produced by sodium depletion and unilateral nephrectomy: a new experimental model.
Unilateral nephrectomy of sodium-restricted male Sprague-Dawley rats produced a sustained elevation in systolic blood pressure (SBP) that was reversed by sodium repletion. A chronic intraperitoneal infuson of SQ14,225 prevented the development of hypertension in sodium-deplete unilaterally nephrectomized rats. Sodium depletion of two-kidney rats increased SBP to a lesser extent, while unilateral nephrectomy of sodium replete animals had no effect. These results provide evidence for a new model of experimental hypertension in the rat and emphasize the importance of a renal component, as demonstrated by unilateral nephrectomy, in the maintenance of normal pressure-volume relationships.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology; D004195:Disease Models, Animal; D006973:Hypertension / Q000209:etiology*; D008297:Male; D009392:Nephrectomy; D051381:Rats; D012964:Sodium / Q000172:deficiency
D002216:Captopril; D012964:Sodium