Inhibition of vitamin D2-induced arteriosclerosis in rats by depletion of complement with cobra venom factor.
Widespread calcerous deposits developed in the aorta, heart and kidneys of rats fed for 4 days with purina chow and high doses of vitamin D2 (200,000 IU/kg body wt/day). Decomplementation of rats with highly purified cobra venom factor (CoF) prior to vitamin D2 feeding, almost completely prevented calcium deposition in the aorta and arteritis. The mortality rate in the CoF-treated vitamin D2-fed rats was much lower than in untreated rats. These findings suggest that the complement system may be recruited in the pathogenesis of vitamin D2-induced arteriosclerosis.
D000818:Animals; D001161:Arteriosclerosis / Q000139:chemically induced*; D002114:Calcinosis / Q000473:pathology; D003176:Complement C3; D003165:Complement System Proteins / Q000172:deficiency*; D004305:Dose-Response Relationship, Drug; D004546:Elapid Venoms / Q000494:pharmacology*; D004872:Ergocalciferols; D005455:Fluorescent Antibody Technique; D006801:Humans; D007668:Kidney / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D011817:Rabbits; D051381:Rats; D012756:Sheep
D003176:Complement C3; D004546:Elapid Venoms; D004872:Ergocalciferols; D003165:Complement System Proteins