title: Drug-induced changes in airways obstruction reflected by forced expiratory flows and airway resistance measured with an oscillometric method using quiet breathing.
abstract: 14 patients with partially reversible airways obstruction were studied with forced expiratory flows (FEV1, PEFR) and with airway resistance measured by an oscillometric method (Siregnost FD-5) before and after drug-induced changes in airways obstruction. 10 inhaled methacholine to induce bronchoconstriction, and 4 inhaled salbutamol and an additional dose of neosynephrine to induce bronchodilation. Intraindividual changes in resistance (Rosc) measured by the oscillometer with quiet breathing showed a fair significant correlation with changes in FEV1 (r = 0.54, p less than 0.05) and changes in PEFR measured by the Wright peak flow meter (r = 0.59, p less than 0.05). The present type of oscillator can be used for provocations starting from normal airway resistance but not for measures of treatment effects in markedly obstructive patients.
mesh_terms: D000328:Adult; D000368:Aged; D000403:Airway Resistance; D000420:Albuterol / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000627:therapeutic use*; D008875:Middle Aged; D009784:Occupational Diseases / Q000188:drug therapy / Q000503:physiopathology; D009991:Oscillometry / Q000379:methods*; D010656:Phenylephrine / Q000627:therapeutic use*; D014797:Vital Capacity
chemical_list: D008688:Methacholine Compounds; D016210:Methacholine Chloride; D010656:Phenylephrine; D000420:Albuterol