Dietary modification of the vascular effect of prostacyclin in hypertensive rats.
Hypertension increased the responsiveness of spontaneously hypertensive rats (SHR) to exogenously infused prostacyclin (PGI2) at rates of 300 ng/kg/min and 1 microgram/kg/min. This did not occur for angiotensin infusion. Substitution of a diet containing alpha-linolenic acid for the control diet to SHR abolished this increased responsiveness to PGI2. Accompanying the abolition of the increased responsiveness to PGI2 was a significant increase in specific activity of two lysosomal hydrolases (N-acetylglucosaminadase and cathepsin D) within the aorta of SHR. These changes may reflect compensatory responses of the vasculature to protect the animal.
D000118:Acetylglucosaminidase / Q000378:metabolism; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000201:enzymology; D001794:Blood Pressure / Q000187:drug effects*; D002402:Cathepsin D; D002403:Cathepsins / Q000378:metabolism; D004032:Diet; D011464:Epoprostenol / Q000494:pharmacology*; D006973:Hypertension / Q000503:physiopathology*; D008042:Linolenic Acids / Q000494:pharmacology*; D011453:Prostaglandins / Q000494:pharmacology*; D051381:Rats
D008042:Linolenic Acids; D011453:Prostaglandins; D000804:Angiotensin II; D011464:Epoprostenol; D000118:Acetylglucosaminidase; D002403:Cathepsins; D002402:Cathepsin D