title: Abnormal water turnover associated with hypothalamic obesity.
abstract: Experimental obesity produced in rats by stereotaxic lesions of the ventromedial hypothalamus (VMH) resulted in hyperphagia, polydipsia, polyuria, decreased urine osmolality, and enhanced excretion of total solute and urea. A 24-h water deprivation test revealed the inability of VMH-lesioned rats to increase urine antidiuretic hormone (ADH) excretion. Thus, destruction of the VMH area appears to be accompanied by impairment of ADH secretion, resulting in a diabetes insipidus syndrome that is partially masked by food restriction and improved by treatment with exogenous ADH.
mesh_terms: D000818:Animals; D001769:Blood; D001834:Body Water / Q000378:metabolism*; D004326:Drinking; D005260:Female; D007031:Hypothalamus / Q000502:physiology*; D009765:Obesity / Q000378:metabolism*; D009994:Osmolar Concentration; D051381:Rats; D013238:Stereotaxic Techniques; D014556:Urine