title: Venous extravasation of doxorubicin HCl with secondary skin ulceration.
abstract: With increased use of the potent anticancer drug doxorubicin HCl (Adriamycin), there are increasing numbers of reports of local severe tissue damage at the venous administration sites. I have described a 70-year-old woman in whom extravasation of this drug produced a characteristic indolent ulcer on the hand and wrist. Expectant nonoperative care was followed six weeks later by debridement and a split-thickness skin graft which failed to take. Repeat debridement with porcine grafts stimulated granulation tissue, so that split-thickness skin grafting could give an acceptable functional and cosmetic result.
mesh_terms: D000368:Aged; D000818:Animals; D001684:Biological Dressings; D001943:Breast Neoplasms / Q000556:secondary; D004317:Doxorubicin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous / Q000009:adverse effects*; D009362:Neoplasm Metastasis / Q000188:drug therapy*; D016038:Skin Transplantation; D012883:Skin Ulcer / Q000139:chemically induced* / Q000628:therapy; D014182:Transplantation, Autologous
chemical_list: D004317:Doxorubicin