title: The relationship between blood glycosylated haemoglobin and home capillary blood glucose levels in diabetics.
abstract: Serial capillary blood glucose levels from insulin treated patients were recorded over 24 hour periods at fortnightly intervals for three months. Total glycosylated haemoglobin as % of HbA was measured at the end of this period by the Flückiger method, and % HbA1 by column chromatography. There were highly significant correlations between mean blood glucose levels over the three months and % HbA1 (r = 0.93, 95% confidence limits 0.84-0.98), and with total glycosylated haemoglobin (r = 0.88, 95% confidence limits 0.75-0.94). There was also a good correlation between results obtained by the two methods (r = 0.81, p less than 0.0001). There were less strong correlations between % HbA1 and blood glucose levels during each of the three months before the estimation, with percentage of glucose levels greater than 10 mmol/l and with mean fasting blood glucose. These data support the hypothesis that % HbA1 and total glycosylated haemoglobin are satisfactory measurements of short term diabetic control.
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D001800:Blood Specimen Collection; D002196:Capillaries; D003920:Diabetes Mellitus / Q000097:blood*; D005215:Fasting; D006027:Glycosides / Q000032:analysis*; D006441:Hemoglobin A / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008875:Middle Aged; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D006027:Glycosides; D007328:Insulin; D006441:Hemoglobin A