Arachidonic acid metabolism, pain and hyperalgesia: the mode of action of non-steroid mild analgesics.
1 Cyclo-oxygenase products such as prostaglandins of the E series and prostacyclin produce the hyperalgesia associated with inflammation. 2 These substances may cause pain and incapacity in some inflammatory conditions. 3 Prostaglandin E2 sensitizes the chemical receptors of afferent pain endings to other inflammatory mediators such as bradykinin and histamine. 4 Unstable intermediates formed in the generation of prostaglandins may also play a role in the production of pain. 5 Drugs such as indomethacin and aspirin which are potent inhibitors of prostaglandin biosynthesis may exert their analgesic effect through this mechanism.
D000700:Analgesics / Q000494:pharmacology*; D001095:Arachidonic Acids / Q000378:metabolism*; D001241:Aspirin / Q000494:pharmacology; D011464:Epoprostenol / Q000502:physiology; D006801:Humans; D006930:Hyperalgesia / Q000378:metabolism*; D006941:Hyperesthesia / Q000378:metabolism*; D010146:Pain / Q000378:metabolism*; D011453:Prostaglandins / Q000502:physiology
D000700:Analgesics; D001095:Arachidonic Acids; D011453:Prostaglandins; D011464:Epoprostenol; D001241:Aspirin