Dna repair: pathways and defects.
Damaged DNA can be repaired by three different mechanisms: photoreactivation, excision repair and postreplication repair. Each mechanism is regulated by a highly specific set of enzymes. Defects within these systems result in diseases which have one common feature: affected individuals are cancer prone. Recently, newly developed methods not only make it possible to diagnose affected patients but also to detect individuals at risk. Furthermore, the results obtained elucidate some mechanisms of carcinogenesis. Clinical applications are discussed.
D001260:Ataxia Telangiectasia / Q000235:genetics; D002471:Cell Transformation, Neoplastic; D003057:Cockayne Syndrome / Q000235:genetics; D004260:DNA Repair; D004261:DNA Replication; D004255:Deoxyribodipyrimidine Photo-Lyase / Q000172:deficiency; D005199:Fanconi Anemia / Q000235:genetics; D006130:Growth Disorders / Q000235:genetics; D006801:Humans; D008027:Light; D011371:Progeria / Q000235:genetics; D012306:Risk; D013577:Syndrome; D014898:Werner Syndrome / Q000235:genetics; D014983:Xeroderma Pigmentosum / Q000235:genetics
D004255:Deoxyribodipyrimidine Photo-Lyase