Detection of autoplaque-forming cells as a means for characterizing the state of reactivity of the child organism.
Counts of plaque-forming cells [PFC] in blood were determined by the method of N. N. Klemparskaya in 181 children aged 1 to 3 years living in an organized community. A raised level of autoantibody-producing cells was detected in 45% of the children. The causes responsible for this enhanced autoimmunization may have been different infectious diseases. On the basis of phenomenon of PFC count increase in the presence of penicillin in specimens in vitro, hypersensitivity to thi antibiotic in the absence of clinical manifestations of allergy was detected in 27% of children.
D000485:Allergens; D000921:Antibody-Producing Cells / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D002644:Chickenpox / Q000276:immunology; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006462:Hemolytic Plaque Technique; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000276:immunology; D008171:Lung Diseases / Q000276:immunology; D008297:Male; D010406:Penicillins / Q000276:immunology
D000485:Allergens; D001323:Autoantibodies; D010406:Penicillins