Gastrointestinal microbleeding: comparisons between benoxaprofen and other nonsteroidal antiinflammatory agents.
Unlike other nonsteroidal antiinflammatory agents, benoxaprofen has only minor antiprostaglandin synthetase activity. This property may explain the lack of gastric irritation seen in animal studies. To evaluate gastric irritation in man, benoxaprofen was compared with aspirin, naproxen, ibuprofen, sulindac, and indomethacin by measuring fecal blood loss with chromium-51 tagged red blood cells in randomized double-blind crossover and parallel studies. Benoxaprofen produced significantly less blood loss than aspirin, naproxen, or indomethacin, and less blood loss than ibuprofen or sulindac. Benoxaprofen also caused the fewest gastrointestinal complaints.
D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001241:Aspirin / Q000009:adverse effects; D001583:Benzoxazoles / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects; D008551:Melena / Q000139:chemically induced; D009288:Naproxen / Q000009:adverse effects; D011422:Propionates / Q000009:adverse effects*; D011453:Prostaglandins / Q000502:physiology; D013467:Sulindac / Q000009:adverse effects; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D001583:Benzoxazoles; D011422:Propionates; D011453:Prostaglandins; C011677:benoxaprofen; D013467:Sulindac; D009288:Naproxen; D001241:Aspirin; D007213:Indomethacin