title: The effect of glucose on plasma immunoreactive secretin in normal man and after gastrectomy or pancreatectomy.
abstract: Oral intake of glucose increased the peripheral plasma immunoreactive secretin (IRS) concentration in patients after total pancreatectomy with duodenectomy (p < 0.05) and in patients after total gastrectomy (p < 0.01). In young healthy volunteers and in patients after partial gastrectomy, no effect on IRS was observed. Intravenous glucose reduced the IRS concentration in pancreatectomized patients (p < 0.05), whereas IRS was only reduced in young healthy volunteers when intravenous glucose was followed by oral glucose after an interval of 10 min (p < 0.025). The abnormal IRS release in pancreatectomized patients and in patients after total gastrectomy might be due to rapid intestinal passage and/or increased splanchnic blood flow induced by hypertonic glucose. A third possibility is that a glucose-induced increase in bile flow might release IRS.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D005743:Gastrectomy; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D007328:Insulin / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D012633:Secretin / Q000097:blood / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D007328:Insulin; D012633:Secretin; D005947:Glucose