Metabolic formation of pyrenequinones as enhancing agents of mutagenicity in Salmonella.
Pyrene and 1-methylpyrene in the pyrolysis product of cellulose, which enhances mutagenicity of 2-acetylaminofluorene, must be metabolized to expose enhancing activity. 1,6-Pyrenequinone and 1,8-pyrenequinone, having high enhancement activity, were first isolated and identified in the metabolites of pyrene by rat liver microsomal fraction.
D015073:2-Acetylaminofluorene / Q000633:toxicity*; D001711:Biotransformation; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism* / Q000633:toxicity*; D011721:Pyrenes / Q000378:metabolism* / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects
D009153:Mutagens; D011721:Pyrenes; D015073:2-Acetylaminofluorene; C031174:1,6-pyrenequinone; C031175:1,8-pyrenequinone