title: Safety and efficacy of a new synthetic burn dressing: a multicenter study.
abstract: A three-tiered, multicenter study evaluated the safety and efficacy of a new synthetic dressing for burn injuries. The first tier compared use of the test dressing with use of a conventional topical chemotherapeutic agent; the test dressing afforded greater patient comfort, equivalent control of bacterial growth, less frequent dressing change, and possibly faster reepithelialization. Drawbacks included difficulty of application, poor adherence during the first 24 hours after injury, frequent necessity to repair cracks and fissures, and inability to easily monitor burn wounds for bacterial growth. Subsequent tiers were noncomparative but included patients with more severe injuries. The test dressing may be useful in treating superficial and moderate second-degree burns of less than 20% of the total body surface area and possibly in treating iatrogenic "burn" wounds such as donor sites. Its use on third-degree burns is not recommended.
mesh_terms: D000179:Acrylates / Q000008:administration & dosage*; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D001830:Body Surface Area; D002056:Burns / Q000382:microbiology / Q000628:therapy*; D002648:Child; D002986:Clinical Trials as Topic; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008689:Methacrylates / Q000008:administration & dosage*; D008875:Middle Aged; D009779:Occlusive Dressings; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D012449:Safety; D012867:Skin / Q000382:microbiology; D013411:Sulfadiazine / Q000008:administration & dosage; D014945:Wound Healing
chemical_list: D000179:Acrylates; D008689:Methacrylates; D013411:Sulfadiazine; D011092:Polyethylene Glycols