Effect of 1 alpha-hydroxycholecalciferol on the skeletal mineral metabolism and bone morphogenesis.
Administered 1 alpha-OH-D3 is hydrolyzed in liver and then converted to active 1 alpha, 25-(OH)2-D3. An increased serum calcium content was observed in rats administered 1 alpha-OH-D3. No calcium and magnesium increase was noticed in cortical bone due to 1 alpha-OH-D3 administration. Morphogenesis of bone and cartilage in implanted bone matrix in a group of 1 alpha-OH-D3 administered host rats seemed relatively increased to a slight extent.
D000375:Aging; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001846:Bone Development; D001857:Bone Matrix / Q000187:drug effects / Q000502:physiology; D016025:Bone Transplantation; D001842:Bone and Bones / Q000187:drug effects; D002118:Calcium / Q000032:analysis / Q000097:blood; D002356:Cartilage / Q000187:drug effects / Q000502:physiology; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D008274:Magnesium / Q000032:analysis; D010710:Phosphates / Q000097:blood; D051381:Rats; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
D006887:Hydroxycholecalciferols; D010710:Phosphates; D000469:Alkaline Phosphatase; D008274:Magnesium; D002118:Calcium; C008088:alfacalcidol