[Toxicological study of the new antiviral agent, 5-bromuridine].
Toxicity of the new antiviral drug 5-bromuridine was studied in experiments on laboratory animals at systemic and local administration. The drug proved to be little toxic. Studies of acute toxicity of the drug administered systemically (intraperitoneally, intravenously and per os) showed it to be well tolerable by animals at concentrations 10-20 fold and 150-300 fold (with reference to an average weight of human body) exceeding the doses recommended for humans at local administration. As compared to controls no changes in the animals' state, peripheral blood and in its principal functional and biochemical parameters, in the activity of serum enzymes as well as in the microstructure of internal organ tissue were revealed during prolonged local administration of the drug to the animals under conditions similar to clinical ones but at higher concentrations and longer exposure.
D000818:Animals; D000998:Antiviral Agents / Q000633:toxicity*; D001769:Blood / Q000187:drug effects; D001976:Bromouracil / Q000031:analogs & derivatives; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D005123:Eye / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D011817:Rabbits; D013997:Time Factors; D014529:Uridine / Q000031:analogs & derivatives* / Q000633:toxicity
D000998:Antiviral Agents; D001976:Bromouracil; C006824:5-bromouridine; D014529:Uridine
Toksikologicheskoe izuchenie novogo protivovirusnogo preparata 5-bromuridina.