Allotype suppression of the responsiveness of adoptively transferred adult spleen cells induced by affinity prepared anti-allotype antibody.
In an adoptive transfer assay it has been shown that a form of allotype suppression can be induced in adult spleen cells. Use of SPF congenic mice, and either anti-allotype serum freed of IgM rheumatoid factor or affinity prepared antibody, has helped to eliminate the possibility of a role for non-specific factors in allotype suppression. Both memory-cell development and a conventional primary response are more susceptible to suppression than memory expression in a secondary response. Non-specific suppressive effects on isotypes other than that of the target allotype (CH) are present but are much smaller than for specific suppression.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D000915:Antibody Affinity; D005260:Female; D007126:Immunoglobulin Allotypes / Q000276:immunology*; D007156:Immunologic Memory; D007163:Immunosorbent Techniques; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D013154:Spleen / Q000276:immunology* / Q000637:transplantation; D013997:Time Factors; D014184:Transplantation, Homologous
D000888:Antibodies, Anti-Idiotypic; D007126:Immunoglobulin Allotypes