Focal mesangial proliferative glomerulonephritis in the rat caused by Habu venom: the effect of antiplatelet agents.
The effects of the antiplatelet agents aspirin (ASA), dipyridamole (DP) and prostacyclin (PGI2) on glomerulonephritis following Habu snake venom have been investigated. ASA greatly increases glomerular damage and PGI2 inhibits glomerular damage. DP suppresses glomerular proliferation. The results extend previous studies on platelet activity in this model and provide evidence that (1) glomerular injury involves a platelet/endothelial reaction and (2) glomerular proliferation is affected by an antiplatelet drug.
D000818:Animals; D001241:Aspirin / Q000627:therapeutic use*; D001792:Blood Platelets / Q000187:drug effects; D004176:Dipyridamole / Q000627:therapeutic use*; D011464:Epoprostenol / Q000627:therapeutic use*; D005921:Glomerulonephritis / Q000188:drug therapy*; D005923:Glomerulosclerosis, Focal Segmental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D010976:Platelet Count; D011453:Prostaglandins / Q000627:therapeutic use*; D051381:Rats; D011917:Rats, Inbred Lew; D012910:Snake Venoms
D011453:Prostaglandins; D012910:Snake Venoms; D004176:Dipyridamole; D011464:Epoprostenol; D001241:Aspirin