Extracorporeal immunoadsorption of myeloma IgG and autoimmune antibodies: a clinically feasible modality of treatment.
Using heat-killed, formalin-stabilized Staphylococcus aureus Cowan I suspension, it was possible to remove myeloma IgG and autoimmune anti-red blood cell antibodies from two patients' plasma following an extracorporeal procedure. The arterial anticoagulated blood was processed through a cell separator machine. The separated plasma was pumped through a bacterial filter containing S. aureus suspension. The adsorbed plasma was then reunited with the blood cells and returned to the patient through the vein. S. aureus Cowan I could selectively remove the myeloma IgG and autoimmune anti-red cell antibodies from the patients' plasma prolonging the lives of these two terminal patients. The immunoadsorption procedure appears to be a safe, practical and quick method for the removal of pathological IgG from the patients' plasma.
D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000628:therapy; D001323:Autoantibodies / Q000032:analysis*; D004912:Erythrocytes / Q000276:immunology; D005112:Extracorporeal Circulation; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007163:Immunosorbent Techniques; D007164:Immunosorbents; D007945:Leukemia, Lymphoid / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000628:therapy; D009194:Myeloma Proteins / Q000032:analysis*; D013211:Staphylococcus aureus / Q000276:immunology
D001323:Autoantibodies; D007074:Immunoglobulin G; D007164:Immunosorbents; D009194:Myeloma Proteins