[New information on the biotransport of the x-ray contrast substance, bilignost, in the hepatocyte].
Electron microscopic studies on rats have shown that promptly (30 sec--5 min) after administration to the portal vein, bilignost progresses diffusely, through the cell membrane, from Disse's space and intercellular slits to the hepatocytic cytoplasm. It is accumulated by the cytoplasm and subcellular organellas and then is rapidly eliminated from the cells to bile capillaries.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002765:Cholecystography; D003287:Contrast Media / Q000378:metabolism*; D006651:Histocytochemistry; D007458:Iodipamide / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D051381:Rats
D003287:Contrast Media; D007458:Iodipamide
Novye svedeniia o biotransporte rentgenokontrastnogo veshchestva bilignosta v gepatotsite.