Antibiotic resistance of indole-positive Klebsiella pneumoniae.
Resistance patterns to antibiotics differed markedly between indole-positive and indole-negative Klebsiella pneumoniae strains. Multiple-drug-resistant strains were almost exclusively indole-negative. Ampicillin and kanamycin resistances in the indolepositive strains tested were not transmissible, whereas many of those resistances in the indole-negative strains were transmissible, together with other drug resistances to an Escherichia coli recipient. The substrate profile of the beta-lactamase from the indole-positive strains was fairly different from that of the beta-lactamase mediated by the ampicillin resistance plasmid.
D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003227:Conjugation, Genetic; D004926:Escherichia coli / Q000187:drug effects; D007211:Indoles / Q000096:biosynthesis; D007612:Kanamycin / Q000494:pharmacology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000378:metabolism; D010403:Penicillin Resistance; D001618:beta-Lactamases / Q000378:metabolism
D000900:Anti-Bacterial Agents; D007211:Indoles; D007612:Kanamycin; D000667:Ampicillin; D001618:beta-Lactamases