[Mode of action of simultaneous vaccination with live antigens and specific antibodies].
Immunogenicity of live vaccine was not substantively affected by physiological antibody doses. Antibody did not change in vivo germ survival rates. The vaccine germ was isolated by tissue culturing from spleen and liver even after 42 days. Elimination from circulation was accelerated by antibody. The immunisation dose of pathogenic germs was considerably increased by means of specific immunoglobulins, which altogether improved the immunisation effect. Immunogenicity can be increased by antibody only in an indirect way and by means of vaccine doses generally not tolerated.
D000818:Animals; D000907:Antibodies, Bacterial / Q000008:administration & dosage* / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D001769:Blood / Q000382:microbiology; D004926:Escherichia coli / Q000254:growth & development / Q000276:immunology* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000517:prevention & control*; D008099:Liver / Q000382:microbiology; D051379:Mice; D013154:Spleen / Q000382:microbiology
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines
Uber die Wirkungsweise von Simultanimpfungen mit Lebendantigenen und spezifischen Antikörpern.