Cytogenetic evidence for the clonal nature of Richter's syndrome.
Sequential chromosome studies were done on a patient who developed diffuse histiocytic lymphoma (DHL) after a long history of untreated chronic T-cell leukemia. During the indolent phase of her disease, a pseudodiploid lymphocyte population with 3q+ and 14q+ chromosome markers gradually replaced the originally diploid tumor cells. The karyotype of the lymphoma was hypertriploid (70--74 chromosomes) with the same 3q+ and 14q+ markers. The findings indicate that DHL in this patient evolved from the leukemic T-cell clone.
D002999:Clone Cells; D003165:Complement System Proteins; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications / Q000473:pathology*; D008214:Lymphocytes / Q000166:cytology*; D008223:Lymphoma / Q000209:etiology*; D008875:Middle Aged; D008934:Mitogens; D012397:Rosette Formation
D008934:Mitogens; D003165:Complement System Proteins