Prevention of endotoxin-induced arterial hypoxaemia and lactic acidosis with flunixin meglumine in the conscious pony.
Bacterial endotoxin injected intravenously into conscious ponies produced alterations in cardiopulmonary and gastrointestinal function. Specifically, tachypnoea, dyspnoea, hypoxaemia, colic, lactic acidosis and diarrhoea resulted from administration of 10 micrograms/kg Escherichia coli endotoxin. Pretreatment of the ponies with a potent prostaglandin synthetase inhibitor, flunixin meglumine, prevented these ill effects of endotoxin.
D000138:Acidosis / Q000517:prevention & control / Q000662:veterinary*; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D001784:Blood Gas Analysis / Q000662:veterinary; D002339:Carotid Arteries; D003002:Clonixin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D004731:Endotoxins; D004926:Escherichia coli; D006734:Horse Diseases / Q000517:prevention & control*; D006736:Horses; D000860:Hypoxia / Q000517:prevention & control / Q000662:veterinary*; D007773:Lactates / Q000097:blood*; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D009539:Nicotinic Acids / Q000627:therapeutic use*
D001639:Bicarbonates; D004731:Endotoxins; D007773:Lactates; D009539:Nicotinic Acids; D008536:Meglumine; C014558:flunixin meglumine; D003002:Clonixin