Effect of ATP-MgCl2 treatment on kidney preservation and on recovery of graft function.
The effect of ATP-MgCl2 treatment was investigated on the biochemical changes of preserved kidneys and on the functional recovery of hypoxically damaged and autotransplanted canine kidneys. We observed that ATP-MgCl2 administered before or during simple hypothermic storage did not protect the integrity of preserved kidney cells, as measured by enzyme wash-out (LDH and NAG) or by lactate release. If the compound was administered after 120 min or 180 min clamping of the renal artery, the solitary kidney showed a faster regeneration as measured by changes in serum creatinine level. The survival rates were significantly higher in the treated groups. Without warm ischemia of the kidney all of the autotransplanted dogs survived after surgery. After 60 min of warm ischemia the mortality rate was 100%, and the mean survival time in average 5 days. If ATP-MgCl2 was administered after the 60 min of warm ischemia, an improved recovery of the graft function was observed
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D003404:Creatinine / Q000097:blood; D004285:Dogs; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects; D016030:Kidney Transplantation; D008297:Male; D009926:Organ Preservation / Q000379:methods*; D014021:Tissue Preservation / Q000379:methods*; D014182:Transplantation, Autologous
D000255:Adenosine Triphosphate; D003404:Creatinine