title: Airway closure during anaesthesia, and its prevention by positive end expiratory pressure.
abstract: Airway closure, functional residual capacity (FRC) and the transpulmonary pressure volume relationship of each lung were studied in the anaesthetized subject in the supine and the left lateral positions. In the supine posture, FRC was of approximately the same size in each lung as was closing capacity (CC). CC exceeded FRC in either lung. In the left lateral position, FRC was increased by 0.91 in the non-dependent lung and was reduced by 0.21 in the dependent lung, while CC was unaltered in either lung. Consequently, FRC exceeded CC in the non-dependent lung and was further lowered beneath CC in the dependent lung. Airway closure did not occur in the non-dependent lung until an average of 0.51 of gas had been expelled after the dependent lung had ceased to empty. The addition of positive end-expiratory pressure (PEEP) in the range 0.5-2 kPa, increased FRC more in the non-dependent than the dependent lung. The findings suggest that airway closure is evenly distributed in the horizontal level, while it has a discontinuous distribution between the dependent and non-dependent lung. Moreover, the increase in lung volume caused by PEEP has a distribution that is by no means ideal for the purpose of countering airway closure.
mesh_terms: D000328:Adult; D000368:Aged; D000402:Airway Obstruction / Q000209:etiology*; D000768:Anesthesia, General; D000769:Anesthesia, Inhalation; D003011:Closing Volume; D005652:Functional Residual Capacity; D006801:Humans; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration; D012115:Residual Volume; D014797:Vital Capacity