Effect of Bacillus Calmette-Guérin on the development of primary lung cancer in Syrian golden hamsters.
The effect of a single systemic or intratracheal administration of viable Mycobacterium bovis strain Bacillus Calmette-Guérin on the development of primary lung cancer in Syrian golden hamsters was assessed. M. bovis strain Bacillus Calmette-Guérin administered i.v. prior to, during, or after carcinogen treatment did not alter the incidence of lung tumors. Animals receiving intratracheal M. bovis strain Bacillus Calmette-Guérin had an increased incidence of lung tumors. Both i.v. and intratracheal routes accelerated the appearance of tumors.
D000818:Animals; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic; D006224:Cricetinae; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D009163:Mycobacterium bovis / Q000276:immunology*; D011379:Prognosis; D013997:Time Factors
D002273:Carcinogens