Pre-beta 1-lipoprotein in patients with ischemic heart disease. Genetic determination and relation to early insulin response.
The genetic determination of pre-beta 1-lipoprotein and its relation to insulin response was studied in 18 male monozygotic and 13 male dizygotic twin pairs, aged 51-74. They had been selected from the Swedish Twin Registry by means of an angina pectoris questionnaire. Results revealed a heritability index for the pre-beta 1-lipoprotein, determined quantitatively, to be as high as 0.94. The subjects in whom pre-beta 1-lipoprotein was present exhibited a significantly delayed early insulin response compared to subjects without this lipoprotein fraction. Our data seem to justify the use of pre-beta 1-lipoprotein as a genetic marker. Data also indicate that important metabolic differences may exist between pre-beta 1+ and pre-beta 1- individuals, and it is possible that such differences may explain in part an increased susceptibility to ischemic heart disease for those possessing the pre-beta 1 fraction.
D000368:Aged; D003327:Coronary Disease / Q000097:blood* / Q000235:genetics; D004200:Diseases in Twins; D005819:Genetic Markers; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood* / Q000235:genetics; D008297:Male; D008875:Middle Aged
D005819:Genetic Markers; D007328:Insulin; D008055:Lipids; D008079:Lipoproteins, VLDL