[Influence of chronic lead exposure on resistence to bacterial infection (author's transl)].
Suppression by lead of resistance to bacterial or viral infections has been reported by several authors. We have studied, if a decrease of resistance to bacterial infection could be evaluated at blood lead concentrations (PbB), which correspond to the upper levels of environmental or occupational lead exposure regarded as tolerable (PbB = 35 resp. 60 microgram/100 ml). NMRI mice were chronically exposed to lead by feeding with lead acetate containing diets and given a challenge with Salmonella typhimurium. No increase of susceptibility to bacterial infection could be demonstrated at PbB < 90 microgram/100 g. At PbB > 100 microgram/100 g, however, an increase of lethality and a decrease of 50% survival times could be observed after bacterial infection.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007113:Immunity, Innate / Q000187:drug effects*; D007854:Lead / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D011379:Prognosis; D012480:Salmonella Infections / Q000276:immunology*; D012486:Salmonella typhimurium
D007854:Lead
Einfluss einer chronischen Bleibelastung auf die Infektionsresistenz.