A controlled comparison of dipyrone and paracetamol in post-episiotomy pain.
A double-blind, placebo-controlled trial was carried out in 299 patients suffering from post-episiotomy pain to compare the analgesic effectiveness and tolerance of single doses of 500 mg dipyrone and 500 mg paracetamol. Assessments of pain relief over a 6-hour period showed that dipyrone produced significantly better results than placebo within half an hour of intake and maintained this superiority throughout the 6 hours. It also afforded consistently better pain relief than paracetamol and was significantly more effective at the 6-hour assessment. Side-effects were few and mild.
D000082:Acetaminophen / Q000627:therapeutic use*; D000328:Adult; D000632:Aminopyrine / Q000031:analogs & derivatives*; D002986:Clinical Trials as Topic; D004177:Dipyrone / Q000627:therapeutic use*; D004311:Double-Blind Method; D004841:Episiotomy; D005260:Female; D006801:Humans; D010149:Postoperative Pain / Q000188:drug therapy*; D010919:Placebos
D010919:Placebos; D000632:Aminopyrine; D000082:Acetaminophen; D004177:Dipyrone