title: Fat inhibition of gastric acid secretion in duodenal ulcer patients before and after proximal gastric vagotomy.
abstract: In seven duodenal ulcer patients the effect of intraduodenal infusion of 20 ml oleic acid on submaximal gastric acid secretion stimulation by a continuous pentagastrin infusion was evaluated before and after proximal gastric vagotomy. In the control tests 20 ml of saline was given. Before vagotomy, oleic acid evoked a significant inhibition of gastric acid secretion of 25% compared with the controls. This inhibition was abolished after proximal gastric vagotomy. The difference in inhibition before and after vagotomy was significant (P=0.01). It is concluded that the vagus nerve in man plays a decisive role in duodenal fat inhibition of gastric acid secretion.
mesh_terms: D000328:Adult; D003864:Depression, Chemical; D004381:Duodenal Ulcer / Q000503:physiopathology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009829:Oleic Acids / Q000494:pharmacology*; D010418:Pentagastrin / Q000494:pharmacology; D011184:Postoperative Period; D011300:Preoperative Care; D012636:Secretory Rate / Q000187:drug effects; D014628:Vagotomy; D014629:Vagotomy, Proximal Gastric
chemical_list: D007328:Insulin; D009829:Oleic Acids; D010418:Pentagastrin