Cardiovascular malformations experimentally induced in the rat.
Sprague-Dawley rats were treated with glycerol formal during days 6-15 of gestation. 76 to 193 fetuses of these rats examined for visceral malformations showed abnormalities of the heart and great vessels. The principal cardiac malformation was ventricular septum defect associated in 40% of the cases with anomalies of the aortic arch: double aortic arch, right aortic arch and coarctation of the aorta. An attempt was made to explain the specific cardiovascular defects.
D000818:Animals; D001011:Aorta / Q000002:abnormalities; D001013:Aorta, Thoracic / Q000002:abnormalities; D016122:Brachiocephalic Trunk / Q000002:abnormalities; D003330:Coronary Vessel Anomalies / Q000139:chemically induced*; D004148:Dioxolanes / Q000009:adverse effects*; D004149:Dioxoles / Q000009:adverse effects*; D006330:Heart Defects, Congenital / Q000139:chemically induced*; D006345:Heart Septal Defects, Ventricular / Q000139:chemically induced*; D011651:Pulmonary Artery / Q000002:abnormalities; D051381:Rats
D004148:Dioxolanes; D004149:Dioxoles; C025240:glycerol formal