title: [Nature of the mutagenic action of dioxidine on bacteria].
abstract: Lethal and mutagenic action of the antibacterial drug dioxidine was studied in bacteria. The mutagenic action of dioxidine is related to rec A-dependent repair process. The effect of the drug was increased due to mutation of rfa in S. typhimurium causing a destruction of the cell wall polyliposaccharide complex. The mutagenic action of dioxidine was studied as applied to isogenic strains of S. typhimurium bearing the pKM-101 plasmid and to strains lacking the plasmid.
mesh_terms: D000483:Alleles; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D009153:Mutagens; D010957:Plasmids / Q000187:drug effects; D011810:Quinoxalines / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D009153:Mutagens; D011810:Quinoxalines; C001077:dioxidine
vernacular_title: O kharaktere mutagennogo deĭstviia dioksidina na bakterii.