In vitro effects of thymosin, testosterone and growth hormone on antibody formation in murine spleen cells.
The action of growth hormone and testosterone on the immunological activity of thymosin is reported. We have found that growth hormone can significantly stimulate antibody production, as thymosin fraction 5, and that testosterone is inhibitory at high concentrations.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002417:Cattle; D006133:Growth Substances / Q000494:pharmacology*; D006462:Hemolytic Plaque Technique; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012756:Sheep; D013154:Spleen / Q000166:cytology; D013739:Testosterone / Q000494:pharmacology*; D013947:Thymosin / Q000276:immunology / Q000494:pharmacology*; D013950:Thymus Gland / Q000276:immunology; D013951:Thymus Hormones / Q000494:pharmacology*
D006133:Growth Substances; D013951:Thymus Hormones; D013739:Testosterone; D013947:Thymosin