Bone tissue in Paget's disease of bone. Ultrastructure and Immunocytology.
Ultrastructural observation in Paget's disease of bone clarify aspects of bone cells in bone tissue and demonstrate the presence of specific intranuclear inclusions composed of microcylinders in the osteoclasts. The morphologic analysis of these structures suggests an analogy with virus material of the measles group. Results obtained using indirect immunofluorescence and immunoperoxidase techniques lend further support to the hypothesis of a viral etiology in Paget's disease of bone.
D000818:Animals; D001842:Bone and Bones / Q000166:cytology / Q000276:immunology / Q000648:ultrastructure*; D005455:Fluorescent Antibody Technique; D006801:Humans; D008459:Measles virus / Q000276:immunology; D010001:Osteitis Deformans / Q000473:pathology*; D010006:Osteoblasts / Q000648:ultrastructure; D010010:Osteoclasts / Q000648:ultrastructure; D011817:Rabbits