Mechanism of N-hydroxyacetylarylamine mutagenicity in the Salmonella test system: metabolic activation of N-hydroxyphenacetin by liver and kidney fractions from rat, mouse, hamster, and man.
D000082:Acetaminophen / Q000031:analogs & derivatives* / Q000633:toxicity; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001711:Biotransformation; D006224:Cricetinae; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D010261:Paraoxon / Q000494:pharmacology; D010615:Phenacetin / Q000031:analogs & derivatives* / Q000633:toxicity; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics; D013045:Species Specificity
D009153:Mutagens; C008068:N-hydroxyphenacetin; D000082:Acetaminophen; C017372:N-hydroxyacetaminophen; D010615:Phenacetin; D001205:Ascorbic Acid; D010261:Paraoxon