[Influence of GABA-ergic substances on the effects of caudate nucleus stimulation and fenamin stereotyping in cats].
Arrest reaction, circling, cortical spindles induced by electrical stimulation of the caudate nucleus and stereotypy behaviour provoked by threshold doses of amphetamine were recorded in chronic experiments on cats. Sodium hydroxybutyrate and phenibut facilitated motor arrest, while qammalon did not exhibit such an effect. All the substances markedly decreased thresholds of cortical caudate-induced spindles. In contradistinction to gammalon, sodium hydroxybutyrate and phenibut weakened stereotypy behaviour at the same doses of amphetamine that were used in controls, and also interfered with an inhibitory effect of the psychostimulant on the reactions induced by stimulation of the caudate nucleus. It is suggested that the drugs while dopaminergic mechanisms of the neostriatum.
D010129:4-Aminobenzoic Acid / Q000494:pharmacology; D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D002421:Caudate Nucleus / Q000187:drug effects*; D004558:Electric Stimulation; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D012978:Sodium Oxybate / Q000494:pharmacology; D013003:Somatosensory Cortex / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology*
D005680:gamma-Aminobutyric Acid; D012978:Sodium Oxybate; D000661:Amphetamine; C008842:4-amino-3-phenylbutyric acid; D010129:4-Aminobenzoic Acid
Vliianie GAMK-ergicheskikh veshchestv na éffekty stimuliatsii khvostatogo iadra i fenaminovuiu stereotipiiu u koshek.