Curing of Escherichia coli K12 plasmids by coumermycin.
Low concentrations of the antibiotic coumermycin A1, the inhibitor of bacterial DNA gyrase, effectively eliminate pBR322, pMB9 and other ColE 1 related plasmids from E. coli K12 strains. The curing action of antibiotic seems to result from the plasmid degradation and not just from the inhibition of replication.
D049933:Aminocoumarins; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003374:Coumarins / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000235:genetics*; D010957:Plasmids / Q000187:drug effects*; D011758:Pyrroles / Q000494:pharmacology
D049933:Aminocoumarins; D000900:Anti-Bacterial Agents; D003374:Coumarins; D004269:DNA, Bacterial; D011758:Pyrroles; C004628:coumermycin