[Effect of sodium selenite and alpha-tocopherol on the microcirculation in massive blood loss in dogs].
Effect of little doses of sodium selenite combined with alpha-tocopherol on microcirculation was studied in experimental bloodletting in dogs. It was established that more rapid recovery, as compared to control, of blood flow in the visceral basin and more rapid elevation of arterial blood pressure after massive bloodletting occur following the pretreatment with sodium selenite at a dose of 30 micrograms/kg and alpha-tocopherol at a dose of 25 mg/kg. The blood flow gets recovered in small vessels (arterioles, vanules and capillaries) while in controls it recovers largely in greater vessels.
D000818:Animals; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D006439:Hemodynamics / Q000187:drug effects; D006470:Hemorrhage / Q000188:drug therapy*; D008833:Microcirculation / Q000187:drug effects; D020887:Selenious Acid; D012643:Selenium / Q000627:therapeutic use*; D013997:Time Factors; D014810:Vitamin E / Q000627:therapeutic use*
D014810:Vitamin E; D020887:Selenious Acid; D012643:Selenium
Vliianie selenita natriia i al'fa-tokoferola na mikrotsirkuliatsiiu pri massivnoi krovopotere u sobak.