A study of the effectiveness of inosine in renal transplantation.
Kidneys preserved with cold Collins' solution only function satisfactorily if there is no significant preceding period of warm ischaemia. This paper reports an attempt to provide protection to renal function during such a warm ischaemic episode using the nucleotide inosine. In these experiments inosine given intravenously to dogs followed by 15 min of warm renal ischaemia and by either 12 or 24 h of cold preservation with Collins' solution did not protect renal function against the warm ischaemic insult.
D000818:Animals; D003404:Creatinine / Q000097:blood; D004285:Dogs; D007288:Inosine / Q000494:pharmacology*; D007668:Kidney / Q000502:physiology*; D016030:Kidney Transplantation; D009926:Organ Preservation / Q000379:methods*; D014021:Tissue Preservation / Q000379:methods*; D014182:Transplantation, Autologous
D007288:Inosine; D003404:Creatinine