Inhibitors of the acrosomal proteinase acrosin: human urinary trypsin inhibitor (UTI) and 4-(2-carboxyethyl) phenyl trans 4-aminomethylcyclohexanecarboxylate hydrochloride (DV-1006).
Human urinary trypsin inhibitor (UTI) and (4-(2-carboxyethyl) phenyl trans 4-aminoethylcyclohexanecarboxylate hydrochloride (DV-1006) competitively inhibited the human acrosomal proteinase acrosin; Ki values were 1.2 x 10-8 M and 9.4 x 10-7, respectively.
D000176:Acrosin / Q000037:antagonists & inhibitors*; D000177:Acrosome / Q000201:enzymology*; D001667:Binding, Competitive; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008297:Male; D011480:Protease Inhibitors; D013094:Spermatozoa / Q000201:enzymology*; D014148:Tranexamic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D014361:Trypsin Inhibitors / Q000494:pharmacology / Q000652:urine*
D003509:Cyclohexanecarboxylic Acids; D011480:Protease Inhibitors; D014361:Trypsin Inhibitors; C000665:cetraxate; D014148:Tranexamic Acid; D000176:Acrosin