Mutagenicity of several pancreatic carcinogenic derivatives of N-nitrosodipropylamine in the Ames assay.
The mutagenic activity of several N-nitrosamines related to the potent hamster pancreatic carcinogen N-nitrosobis(2-oxopropyl)amine (BOP) has been investigated using the Ames Salmonella/microsomal mutagenicity test system. S9 from the livers of phenobarbital-pretreated hamsters was the source of activating enzyme, and strain TA1530 was the indicator organism. Mutagenicity assays of BOP, N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP), N-nitrosobis(2-hydroxypropyl)amine (BHP), N-nitroso-2,6-dimethylmorpholine (NDMM) and N-nitrosomorpholine (NM) indicate that only HPOP was strongly mutagenic in the absence of the hamster-liver preparation. In the presence of this activation system, NDMM was the most mutagenic, and cis NDMM was 2-3 times more mutagenic than the trans isomer of this compound. BOP and BHP were considerably less mutagenic than HPOP.
D000818:Animals; D001711:Biotransformation; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008862:Microsomes, Liver / Q000378:metabolism; D009025:Morpholines / Q000378:metabolism / Q000494:pharmacology*; D009153:Mutagens; D009602:Nitrosamines / Q000378:metabolism / Q000494:pharmacology*; D010190:Pancreatic Neoplasms / Q000139:chemically induced; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship
D009025:Morpholines; D009153:Mutagens; D009602:Nitrosamines; C014130:N-nitroso-2,6-dimethylmorpholine; C002741:N-nitrosomorpholine; C012457:diisopropanolnitrosamine; C013622:nitrosobis(2-oxopropyl)amine; C013624:N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine