[Prolonged functional times of xenogenic kidney transplants by means of anti-donor brain globulin (ADBG)].
This paper reports about experimental xenografting of kidneys in closely related species (fox-dog) modifying primary graft rejection by treatment of the recipients with anti-donor brain globulin (ADBG). ADBG, produced by immunisation of rabbits with fox brain tissue, in vitro demonstrates cytotoxicity against fox lymphocytes as well as versus dog lymphocytes. In respect of the phylogenetic constellations, the erythrocytes of both species, too, are influenced in hemagglutinating test. However, kidney tissue is said to be unable to adsorb thymocytolytic antibodies of anti brain sera, thus the way of immunosuppression is directed mostly against the lymphocytes of the recipients, causing here twofold survival time compared to untreated controls. MST is 11.2 +/- 2.4 days (n = 5). Cytotoxic antibodies appear on the 8th day after surgery, that means 4 days later than in the controls. Histological findings correspond to those of untreated recipients.
D000818:Animals; D001921:Brain / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D004285:Dogs; D005589:Foxes; D005916:Globulins / Q000276:immunology*; D006084:Graft Rejection; D006384:Hemagglutination; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008214:Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology; D014183:Transplantation, Heterologous
D005916:Globulins
Verlängerte Funktionszeiten xenogener Nierentransplantate durch Anwendung von Anti-Spender-Hirn-Globulin (ADBG).