title: Doxpicomine in postoperative pain.
abstract: In a single-dose study the analgesic activity of 400 mg doxpicomine was compared with 4 and 8 mg morphine administered intramuscularly. Our subjects wee 43 men with moderate or severe postsurgical pain on the first postoperative day. Results of a double-blind trial indicate the analgesic activity of 400 mg intramuscular doxpicomine to be within the range of 8 mg morphine. There was no statistical significance between the effects of 400 mg doxpicomine and 8 mg morphine with the exception of half-hour data where doxpicomine was more effective than morphine. Doxpicomine has a rapid onset of analgesic action, the duration of which is equivalent to that of 8 mg morphine.
mesh_terms: D000328:Adult; D000368:Aged; D000700:Analgesics / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004146:Dioxanes / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy*; D011725:Pyridines / Q000627:therapeutic use*
chemical_list: D000700:Analgesics; D004146:Dioxanes; D011725:Pyridines; D009020:Morphine; C020698:doxpicodin