Reduction of acute pulmonary hypertension by prostacyclin.
Acute pulmonary hypertension was produced in anaesthetized dogs by inflating a balloon in a major branch of the pulmonary artery. Intravenous infusion of prostacyclin lead to a dose-related decrease in pulmonary arterial pressure. Heart rate and cardiac output did not change significantly. There was a concomitant, but more variable decrease in the systemic arterial pressure. Respiratory rate increased significantly. It is concluded that prostacyclin may offer a therapeutic potential in diseases accompanied by pulmonary hypertension, when it is not associated with significant arterial hypotension.
D000818:Animals; D001794:Blood Pressure; D004285:Dogs; D011464:Epoprostenol / Q000627:therapeutic use*; D005260:Female; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D011453:Prostaglandins / Q000627:therapeutic use*; D011651:Pulmonary Artery / Q000503:physiopathology
D011453:Prostaglandins; D011464:Epoprostenol