Antagonistic effects of endurance training and testosterone on alkaline proteolytic activity in rat skeletal muscles.
Endurance swimming training for 8 weeks led to an increase by about 50% of alkaline proteinase activity in musculus extensor digitorum longus and about 10% in musculus soleus of normal male rats as compared to sedentary control rats. This exercise-mediated increase of proteolytic activity was prevented by the simultaneous administration of 10 mg testosterone propionate/kg body weight twice a week. The data suggest that testosterone has a regulatory effect on the alteration of the protein-degradative mechanism during endurance training.
D000818:Animals; D001835:Body Weight; D004247:DNA / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D008297:Male; D009132:Muscles / Q000032:analysis / Q000201:enzymology*; D010447:Peptide Hydrolases / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D011506:Proteins / Q000032:analysis; D051381:Rats; D013739:Testosterone / Q000097:blood / Q000494:pharmacology*
D011506:Proteins; D013739:Testosterone; D004247:DNA; D010447:Peptide Hydrolases