Polyclonal activation of human lymphocytes by bacteria.
The proliferative response of human unseparated lymphocytes, T cells, and B cells to various bacterial strains was investigated. All the bacteria tested induced a proliferative response in unseparated lymphocytes and B cells. T cells were stimulated only after reconstitution with monocytes. Stimulation of umbilical cord blood lymphocytes suggests that the response is polyclonal. We interpret these and previous data as an indication of a common mechanism of resistance against infectious diseases.
D001402:B-Lymphocytes / Q000276:immunology; D001426:Bacterial Proteins / Q000494:pharmacology*; D004926:Escherichia coli; D005312:Fetal Blood / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D009000:Monocytes / Q000276:immunology; D009161:Mycobacterium; D009343:Neisseria / Q000276:immunology; D013205:Staphylococcal Protein A / Q000494:pharmacology*; D013291:Streptococcus; D013601:T-Lymphocytes / Q000276:immunology
D001426:Bacterial Proteins; D013205:Staphylococcal Protein A