Thy-2: a murine thymocyte-brain alloantigen controlled by a gene linked to the major histocompatibility complex.
We describe a new murine cell-surface alloantigen, provisionally designated Thy-2, which is expressed primarily on thymocytes and brain tissue. Although Thy-2 is also expressed at lower levels on bone-marrow and spleen cells, this antigen does not appear to be present on lymph-node, liver, or red blood cells. Immunoprecipitation of surface-labeled thymocyte extracts from a variety of inbred strains reveals this antigen to be a single polypeptide of 150000 daltons. Quantitative membrane immunofluorescence demonstrates that Thy-2 is a minor cell-surface component which is present on the majority of thymocytes. Mice heterozygous at the Thy-2 locus express approximately 50 percent as much antigen as positive homozygotes. Expression of the Thy-2 alloantigen is controlled by a single semidominant gene located approximately 3 cM to the right of the H-2K locus on chromosome 17.
D000042:Absorption; D000818:Animals; D001921:Brain / Q000276:immunology*; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005455:Fluorescent Antibody Technique; D005796:Genes; D008040:Genetic Linkage; D007106:Immune Sera / Q000494:pharmacology; D007519:Isoantigens / Q000235:genetics*; D008285:Major Histocompatibility Complex; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D013601:T-Lymphocytes / Q000276:immunology*
D007106:Immune Sera; D007519:Isoantigens