Formation of mutagens by sorbic acid-nitrite reaction: effects of reaction conditions on biological activities.
Conditions of the reaction between sorbic acid and sodium nitrite generating mutagenic principles were examined. In the rec-assay and the Ames reversion assay, the maximal mutagenic activity was obtained in a pH range of 3.5-4.2. Mutagenic and growth-inhibitor activities of five C-nitro and C-nitroso compounds were studied. The product Y, 2-methyl-1,4-dinitropyrrole, was the strongest mutagen among them.
D004347:Drug Interactions; D005231:Fatty Acids, Unsaturated; D006863:Hydrogen-Ion Concentration; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D009573:Nitrites; D009574:Nitro Compounds / Q000494:pharmacology; D009603:Nitroso Compounds / Q000494:pharmacology; D011758:Pyrroles / Q000494:pharmacology; D012486:Salmonella typhimurium / Q000187:drug effects; D012977:Sodium Nitrite; D013011:Sorbic Acid
D005231:Fatty Acids, Unsaturated; D009153:Mutagens; D009573:Nitrites; D009574:Nitro Compounds; D009603:Nitroso Compounds; D011758:Pyrroles; C028453:2-methyl-1,4-dinitropyrrole; D012977:Sodium Nitrite; D013011:Sorbic Acid