Effect of systemic indomethacin on corneal graft survival in rabbits.
We investigated the effect of systemic indomethacin on corneal graft survival in rabbits. Two weeks following corneal transplants, skin grafts were exchanged between donor-recipient pairs. Indomethacin was started one day prior to transplant and was continued for the duration of the study. Mean graft survival was twice as long in the indomethacin-treated group (P less than 0.001) than in the untreated rabbits.
D000818:Animals; D016039:Corneal Transplantation; D006085:Graft Survival / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology*; D011817:Rabbits; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D007213:Indomethacin