Translation initiation factor 2 alters transcriptional selectivity of Escherichia coli ribonucleic acid polymerase.
Preparations of translation initiation factor IF-2 strongly stimulate the production of rRNA by Escherichia coli RNA polymerase but have little effect on the synthesis of other RNA species. The factor alters the sedimentation characteristics of RNA polymerase holoenzyme. We suggest a mechanism by which IF-2 alters the pattern of transcriptional selectivity of RNA polymerase.
D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism*; D015852:Eukaryotic Initiation Factor-2; D007700:Kinetics; D010448:Peptide Initiation Factors / Q000378:metabolism*; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism*; D012335:RNA, Ribosomal / Q000096:biosynthesis; D012343:RNA, Transfer / Q000378:metabolism; D014158:Transcription, Genetic
D015852:Eukaryotic Initiation Factor-2; D010448:Peptide Initiation Factors; D011506:Proteins; D012335:RNA, Ribosomal; D012343:RNA, Transfer; D012321:DNA-Directed RNA Polymerases