Effects of some antibacterial agents on the phagocytosis of 32P-labelled Escherichia coli by human polymorphonuclear cells.
Gentamicin, trimethroprim, cephalothin, colistin, erythromycin, oxytetracycline and chloramphenicol were studied in a phagocytic system. A radiolabelled strain of E. coli was used as test bacterium and human polymorphonuclear cells were used as phagocytes. Except for trimethoprim and cephalothin, there was a tendency towards depression of the process of phagocytosis in the presence of high concentrations of the various antibiotics. Colistin in a high concentration (83 micrograms/ml) exerted the most significant effect.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D002512:Cephalothin / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D003091:Colistin / Q000494:pharmacology; D004917:Erythromycin / Q000494:pharmacology; D004926:Escherichia coli; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D010118:Oxytetracycline / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects*; D014295:Trimethoprim / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D004917:Erythromycin; D002701:Chloramphenicol; D014295:Trimethoprim; D002512:Cephalothin; D010118:Oxytetracycline; D003091:Colistin