Bacteremia due to Bacteroides fragilis after elective appendectomy in renal transplant recipients.
Bacteremia caused by Bacteroides fragilis occurred in four of 75 children after renal transplantation, and B. fragilis was the most common cause of postoperative bacteremia. Bacteroides bacteremia was significantly associated with performance of elective appendectomy at the time of transplantation (P less than 0.01) and with profound lymphocytopenia (P = 0.01). No patient received antibiotics at the time of surgery or prior to the first positive blood culture, yet B. fragilis was the single organism isolated from blood and abscesses in these patients. A role for lymphocytes in containment of B. fragilis has not been suggested previously, although unexplained occurrence of bacteroides bacteremia in immunocompromised patients has occasionally been reported. Lymphocytes themselves may be important in this host-bacterium interaction, or lymphocytopenia may be the marker for a more generalized deficiency in host defenses.
D000293:Adolescent; D000328:Adult; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001062:Appendectomy / Q000009:adverse effects*; D001442:Bacteroides Infections / Q000097:blood; D001441:Bacteroides fragilis; D001772:Blood Cell Count; D002648:Child; D002675:Child, Preschool; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D008214:Lymphocytes; D008297:Male; D011183:Postoperative Complications / Q000209:etiology; D018805:Sepsis / Q000209:etiology*; D013601:T-Lymphocytes / Q000276:immunology
D000961:Antilymphocyte Serum