Double-blind trial of trimipramine in the treatment of duodenal ulcer.
Twenty-three patients with chronic duodenal ulcer were allocated randomly to receive either trimipramine 25 mg or placebo, as a single night-time dose, for six weeks. Ulcer healing was determined by endoscopy. The ulcer healed in two of 10 patients receiving trimipramine and in seven of 13 patients receiving placebo. Trimipramine in this dosage does not assist ulcer healing.
D002986:Clinical Trials as Topic; D003984:Dibenzazepines / Q000627:therapeutic use*; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000188:drug therapy*; D004724:Endoscopy; D006801:Humans; D010919:Placebos; D011897:Random Allocation; D014299:Trimipramine / Q000008:administration & dosage / Q000627:therapeutic use*
D003984:Dibenzazepines; D010919:Placebos; D014299:Trimipramine