A multicentre study of the effect and tolerance of Ocusert-P-40.
The suitability of treatment with Ocusert-P-40, a lamellar system inserted in the eye and allowing the constant release of pilocarpine, was studied in a group of patients (age range 43-83 years) with wide-angle glaucoma. Those patients completing a 3-week trial were included in an 8 month follow-up study in which the long-term efficacy and tolerance of Ocusert were studied. Treatment was discontinued in 13 of the 42 patients in the 3-week trial owing to initial irritation and retention problems (n = 11) or unsatisfactory control of the intraocular pressure (I.O.P.) (n = 2). Of the 29 patients entering the long-term study, two were withdrawn because of tolerance problems and two as a result of unsatisfactory control of I.O.P. The 25 patients completing the study considered the Ocusert system more convenient and less liable to produce troublesome side-effects than their previous therapy. Ocusert was best tolerated by the younger patients.
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D004343:Drug Implants; D005500:Follow-Up Studies; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007373:Interinstitutional Relations; D007429:Intraocular Pressure / Q000187:drug effects*; D008875:Middle Aged; D010352:Patient Dropouts; D010862:Pilocarpine / Q000008:administration & dosage* / Q000009:adverse effects; D013548:Sweden; D013997:Time Factors
D004343:Drug Implants; D010862:Pilocarpine