Salmonellosis in mice: studies on oral immunization with live avirulent vaccines.
The avirulent Salmonella typhimurium galE strain G30, following oral feeding to mice, developed a state of immunity to a secondary oral challenge with virulent Salmonella typhimurium. This immunity was concommitant with the development of intestinal and serum antibodies and delayed-type hyepersensitivity (DTH) to Salmonella antigens. In contrast, repeated oral doses of a hybrid E. coli vaccine, which expresses the O antigens of Salmonella typhimurium, provided a lesser degree of immunity and, although able to stimulate the formation of serum antibodies, it elicited only a low level of intestinal antibodies and no measurable DTH.
D000284:Administration, Oral; D000818:Animals; D000917:Antibody Formation; D004926:Escherichia coli / Q000276:immunology; D007114:Immunization; D007167:Immunotherapy; D007422:Intestines / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology; D012481:Salmonella Infections, Animal / Q000276:immunology / Q000517:prevention & control*; D012486:Salmonella typhimurium / Q000276:immunology; D014612:Vaccines / Q000276:immunology
D014612:Vaccines