title: An open study of acebutolol, given as a single daily dose in the management of hypertension in the Chulalungkorn Hospital, Thailand.
abstract: In an open study of fifteen patients with essential hypertension, acebutolol, a cardioselective B 1-adrenoceptor antagonist given orally once daily at dosages of between 400 mg and 1200 mg, produced a substantial and progressive reduction in systolic and diastolic arterial pressure and in the tension time index both in the lying and standing position over the 3 months of the trial. The changes from pre-trial values of blood pressure assessments were statistically significant (p less than 0.001). No side-effects were reported and laboratory monitoring of biological parameters revealed no untoward effects of treatment.
mesh_terms: D000070:Acebutolol / Q000008:administration & dosage* / Q000627:therapeutic use; D000284:Administration, Oral; D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D000070:Acebutolol