title: Fetal metabolic response to phloridzin-induced hypoglycemia in pregnant rats.
abstract: Phloridzin, an inhibitor of renal sugar transport, produces an important loss of glucose in urine of treated animals. In order to reduce severely the maternal glucose supply to the fetuses in short-term experiments, we have combined phloridzin administration to pregnant rats with 18 h starvation. Fetuses from starved phloridzin-treated mothers were compared with fetuses from starved mothers. Combined treatment markedly decreases fetal blood glucose concentration (-36%) and fetal liver glycogen stores (-76%). These changes are associated with a decrease in plasma insulin (-25%), a rise in plasma glucagon (+120%) and a marked increase of hepatic PEPCK activity (+400%). It appears from these results that phloridzin treatment for a short duration is able to induce glycogenolysis and the premature appearance of PEPCK in the liver of rat fetuses.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D005333:Fetus / Q000378:metabolism*; D005934:Glucagon / Q000097:blood; D006029:Glycosuria / Q000378:metabolism; D007003:Hypoglycemia / Q000139:chemically induced*; D007328:Insulin / Q000097:blood; D007657:Ketone Bodies / Q000097:blood; D008112:Liver Glycogen / Q000378:metabolism; D010695:Phlorhizin; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced*; D051381:Rats
chemical_list: D001786:Blood Glucose; D007328:Insulin; D007657:Ketone Bodies; D008112:Liver Glycogen; D005934:Glucagon; D010695:Phlorhizin; D010729:Phosphoenolpyruvate Carboxykinase (GTP)