Effects of steroids on wound healing: a review of the literature.
Since some podiatric surgeons are using glucocorticosteroids to minimize postoperative edema and pain associated with traumatic procedures, the effects on wound healing should be understood as much as possible so that maximum results can be achieved with minimal risk to the patient. Considerable animal and human research has been done on the potential wound-healing effects of glucocorticosteroids. Current studies indicate a detrimental wound-healing effect with the use of glucocorticosteroids. Increased infection will also be discussed.
D000818:Animals; D002645:Chickens; D003094:Collagen / Q000096:biosynthesis; D003348:Cortisone / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D004285:Dogs; D005347:Fibroblasts / Q000187:drug effects; D005446:Fluocinolone Acetonide / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology*; D006168:Guinea Pigs; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D007961:Leukocyte Migration-Inhibitory Factors / Q000502:physiology; D008775:Methylprednisolone / Q000494:pharmacology; D051379:Mice; D011817:Rabbits; D051381:Rats; D013718:Tensile Strength / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*
D005938:Glucocorticoids; D007961:Leukocyte Migration-Inhibitory Factors; D005446:Fluocinolone Acetonide; D003907:Dexamethasone; D003094:Collagen; D003348:Cortisone; D006854:Hydrocortisone; D008775:Methylprednisolone