title: [An absence of interaction of sulfametrol-trimethoprim with insulin or sulphonylurea derivatives in diabetics (author's transl)].
abstract: Since diabetics frequently suffer from urinary tract infections which can be successfully treated with a combination of sulphonamide derivatives and the bacteriocide trimethoprim, the question of possible interactions between such agents and diabetic therapy is of interest. A double-blind crossover trial was, therefore, carried out in 10 diabetics who were being treated with insulin, and 10 who were under treatment with sulphonylurea derivatives. Sulfametrol was administered in combination with trimethoprim (= Lidaprim). The blood glucose level was determined 3 times daily. No tendency towards hypoglycaemia was observed under treatment with the active agent in either group of patients. Within 5 days creatinine and blood urea nitrogen had increased to pathological levels in those patients who showed previous renal damage. It is concluded that the lack of interaction of these drugs with diabetes therapy justifies the use of these chemotherapeutic agents in diabetics. They are effective and relatively inexpensive in comparison with other agents. Subjective tolerance is also good.
mesh_terms: D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D008875:Middle Aged; D013420:Sulfamethoxazole / Q000627:therapeutic use; D013453:Sulfonylurea Compounds / Q000627:therapeutic use*; D014295:Trimethoprim / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000209:etiology
chemical_list: D007328:Insulin; D013453:Sulfonylurea Compounds; D014295:Trimethoprim; D013420:Sulfamethoxazole
vernacular_title: Fehlende Interaktion von Sulfametrol-Teimethoprim mit Insulin oder Sulfonylharnstoffderivaten bei der Behandlung von Diabetikern.