Growth patterns of human acute lymphoblastic leukaemia in diffusion chambers befor treatment and after cessation of therapy.
Diffusion Chambers (DC) were used to culture human bone marrow of ALL patients at the beginning and after the cessation of therapy. No growth was observed in patients before treatment, while growth patterns similar to the normal were obtained in patients after 3 years of maintenance therapy. We suggested the possibility of intensifying the multiple drug chemotherapy in ALL without permanent damage of the stem cell proliferative compartment.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D002455:Cell Division; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D003584:Cytological Techniques; D005260:Female; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000188:drug therapy* / Q000473:pathology; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008875:Middle Aged