Concentrations of thromboxane B2 and 6-oxo-prostaglandin F1 alpha in amniotic fluid, decidual tissue, and placenta in the later stages of pregnancy in the rat.
To determine if the levels of TXA2 and PGI2 within the uterus change at parturition in rats, the concentrations of their respective stable products, TXB2 and 6-oxo-PGF1 alpha (6-k-PGF1 alpha) were measured in amniotic fluid, decidual and placental tissues by specific radioimmunoassays which have been verified by gas chromatography-mass spectrometry. Samples were collected on days 15, 20, 21, and 22 of pregnancy and during labor on day 23. In general, levels of TXB2 and 6-k-PGF1 alpha as well as those of PGE and PGF were highest during labor on day 23, although levels of TXB2 and 6-k-PGF1 alpha in amniotic fluid and decidual tissue, respectively, peaked on day 22. The concentrations were generally highest in decidual tissue, and lowest in amniotic fluid. These findings suggest that TXA2 and PGI2 may have a role in parturition in rats.
D006907:17-alpha-Hydroxypregnenolone / Q000097:blood; D015121:6-Ketoprostaglandin F1 alpha; D000653:Amniotic Fluid / Q000378:metabolism*; D000818:Animals; D003656:Decidua / Q000378:metabolism*; D011464:Epoprostenol / Q000378:metabolism; D004958:Estradiol / Q000097:blood; D005260:Female; D007743:Labor, Obstetric; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal; D011374:Progesterone / Q000097:blood; D011460:Prostaglandins F / Q000378:metabolism*; D051381:Rats; D013928:Thromboxane A2 / Q000378:metabolism; D013929:Thromboxane B2 / Q000378:metabolism*; D013931:Thromboxanes / Q000378:metabolism*
D011460:Prostaglandins F; D013931:Thromboxanes; D006907:17-alpha-Hydroxypregnenolone; D011374:Progesterone; D004958:Estradiol; D013929:Thromboxane B2; D013928:Thromboxane A2; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol