Mitochondrial control of cell surface characteristics in Saccharomyces cerevisiae.
Defects in the inner mitochondrial membrane of petite mutants of yeast resulted not only in respiratory deficiency, but also in changes in cell surface characteristics. These were (1) concanavalin A agglutinability, (2) cell movement in a biphasic polymer system, (3) cell adhesion. Genetic analysis indicated that the control exerted by the mitochondria was on nuclear genes or on the products of these genes which were presumably specifying cell surface components. These findings ascribe a new role to mitochondria but also have implications for neoplastic transformation.
D002449:Cell Aggregation / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D008928:Mitochondria / Q000378:metabolism*; D009068:Movement; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000235:genetics; D013499:Surface Properties
D003208:Concanavalin A