title: A comparative study of benoxaprofen and indomethacin in ankylosing spondylitis.
abstract: Benoxaprofen (600 mg once daily) has been compared to indomethacin (25 mg 3 times daily) in a double-blind crossover study of 20 patients with active ankylosing spondylitis (AS). The clinical improvement was comparable with both drugs; 6 patients preferred benoxaprofen and 7 patients indomethacin. Although 2 patients discontinued benoxaprofen because of lack of effect, no upper gastrointestinal side effects were reported with this drug. Benoxaprofen is an alternative to indomethacin in the treatment of AS.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001583:Benzoxazoles / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011422:Propionates / Q000009:adverse effects / Q000627:therapeutic use*; D013167:Spondylitis, Ankylosing / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D001583:Benzoxazoles; D011422:Propionates; C011677:benoxaprofen; D007213:Indomethacin