Renal effect of SB 7505: a double-blind study.
Two groups of 20 patients with no evidence of cardiovascular, hepatic, renal or gastrointestinal failure were treated orally for five days with placebo or SB 7505 100 mg/day. No change was observed in heart rate or blood pressure. Urine output, the excretion of Na, K and Cl, and creatinine clearance were significantly increased.
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight; D002986:Clinical Trials as Topic; D003846:Deoxyepinephrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004298:Dopamine / Q000031:analogs & derivatives*; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010919:Placebos
D010919:Placebos; C023487:ibopamine; D003846:Deoxyepinephrine; D004298:Dopamine