title: Controlled trial with trithiozine in duodenal ulcer.
abstract: Fifty patients were treated double-blind for 4 weeks: thirty with trithiozine (1200 mg/day) and twenty with placebo. The endoscopic examination at the end of the treatment confirmed the therapeutic effectiveness of the drug, which proved to be significantly more active than the placebo and led to healing of the ulcer in 70% of cases versus 30% in those treated with placebo (p < 0.02). Trithiozine proved to be significantly more effective than placebo in reducing the pain symptoms as well (p < 0.005). In no case did the drug lead to any side-effects.
mesh_terms: D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000188:drug therapy*; D004724:Endoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000627:therapeutic use*; D010919:Placebos
chemical_list: D009025:Morpholines; D010919:Placebos; C012595:trithiozine