Immunologic studies of disseminated infection with Aspergillus fumigatus in the nude mouse.
Immunity to infection with Aspergillus fumigatus conidia was studied in the athymic nude (nu/nu) mouse. The intratracheal, intravenous, and intraperitoneal routes of infection were used. Nu/nu mice were not significantly more susceptible than their heterozygous (nu/+) littermates. However, only nu/+ animals could be protected by prior immunization and developed positive, A. fumigatus-specific skin tests. Protection could be transferred to nu/nu recipients by immune glass-adherent cells. Thus, immunity to invasive aspergillus infection is multifactorial and depends on a glass-adherent cell population and T-cells.
D000818:Animals; D000917:Antibody Formation; D001228:Aspergillosis / Q000276:immunology* / Q000401:mortality; D001232:Aspergillus fumigatus / Q000276:immunology; D002448:Cell Adhesion; D004423:Ear / Q000276:immunology / Q000473:pathology; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007114:Immunization; D007116:Immunization, Passive; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008819:Mice, Nude / Q000276:immunology*; D011817:Rabbits