[Changes in the cholesterol levels of high density lipoproteins following the intravenous administration of triton WR 1339 to rats (author's transl)].
The aim of the present study was to determine, in the rat, changes in the plasma lipids and lipoprotein levels after single or iterative administration of triton WR 1339 in order to elicit the inverse relation between triglyceride and high density lipoprotein levels in man and animal. 24 hours after the acute intravenous injection of triton WR 1339 increases of cholesterol and glyceride were observed while HDL decreased. These effects are potentiated by iterative intravenous administration of triton. According to Nikkila these variations could be explained by the fact that a part of HDL proceeds from the catabulism of lipoproteins rich in glycerides. At the time of the recovery of epuration process, the HDL regeneration from VLDL that are abondant in the plasma should represent the changes observed. The effects found after iterative intravenous administration of triton, confirm that infusion of the detergent induces in the blood a decrease of the catabolism of lipoproteins rich in triglycerides and at the same time the disappearing of blood HDL.
D000818:Animals; D002784:Cholesterol / Q000097:blood*; D007275:Injections, Intravenous; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D014280:Triglycerides / Q000097:blood
D008075:Lipoproteins, HDL; D014280:Triglycerides; D011092:Polyethylene Glycols; D002784:Cholesterol; C016811:tyloxapol
Variations de la teneur en cholestérol des lipoprotéines de haute densité (HDL) après injection intraveineuse de triton WR 1339 chez le rat.