Effect of isocaloric exchange of dietary starch and sucrose in humans on the gastric inhibitory polypeptide response to a sucrose load.
Ten men and nine women aged 35 to 55 consumed two diets for 6 weeks each in a cross-over design. The diets were composed of identical natural foods and 30% of the calories as either sucrose or wheat starch. Carbohydrate, fat and protein supplied 43, 42, and 15% of the calories, respectively. The dietary pattern consisted of two meals divided so as to provide 10% of the calories at breakfast (7:00 to 8:30 AM) and 90% of the calories at dinner (4:30 to 6:30 PM). Initial body weights were essentially maintained. The gastric inhibitory polypeptide response after a sucrose load (2 g/kg body weight) was significantly greater (P < 0.01) after th subjects consumed the sucrose rather than the starch diet. The gastric inhibitory polypeptide response was significantly greater (P < 0.01) after 6 weeks on diet than during pretest. These results suggest that the increases in insulin levels observed after sucrose feeding may be mediated by an effect on the enteric hormone gastric inhibitory polypeptide.
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D005749:Gastric Inhibitory Polypeptide / Q000097:blood*; D005768:Gastrointestinal Hormones / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D013213:Starch / Q000494:pharmacology*; D013395:Sucrose; D014908:Triticum
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D005768:Gastrointestinal Hormones; D007328:Insulin; D013395:Sucrose; D005749:Gastric Inhibitory Polypeptide; D013213:Starch