[Oltipraz as brief treatment of schistosomiasis (comparison with niridazole) (author's transl)].
161 patients affected by schistosomiasis due in most cases to S. haematobium, and less frequently to S. mansoni, received one day treatment with 4,5 g a day of oltipraz in a first group and, later on, 3 g a day in another group. A control after one year was possible for patients having received 4,5 g one day dosis. Urin control, rectal mucosa biopsy (R.M.B.) and indirect immunofluorescence test (I.I.F.) were performed in patients who did not return to infested areas during that period of time; in almost all cases, the urin control was negative; in 52 p. 100 of the cases the R.M.B. shown no live egg and I.I.F. test was significantly decreased with individual variations. -- These results are compared to those of a previous and similar study on the effects of niridazole. -- Side-effects, mostly digestive or nervous, are frequent with a 4,5 g dose and less frequent with 3 g. They rarely compel to discard the treatment and they never persist after the morning following the treatment is stopped. There is no electrocardiographic change. -- Doses below 3 g in one-day intake are presently studied in order to fix the minimal acting dosis.
D000293:Adolescent; D000328:Adult; D004361:Drug Tolerance; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D008875:Middle Aged; D009560:Niridazole / Q000627:therapeutic use*; D010270:Parasite Egg Count; D011719:Pyrazines / Q000627:therapeutic use*; D012007:Rectum / Q000469:parasitology; D012548:Schistosoma haematobium / Q000187:drug effects; D012550:Schistosoma mansoni / Q000187:drug effects; D012552:Schistosomiasis / Q000188:drug therapy* / Q000652:urine; D013871:Thiones; D013876:Thiophenes
D011719:Pyrazines; D013871:Thiones; D013876:Thiophenes; C026209:oltipraz; D009560:Niridazole
Effets de l'oltipraz en traitement bref dans la bilharziose (en comparaison avec le niridazole).