[Gaseous emboli in the rat due to hydrogen peroxide (author's transl)].
1) Hydrogen peroxide (H2O2) kills the rat in 2 or 3 mn by gaseous emboli due to oxygen formation by blood catalyse activity. Venous return and pulmonary circulation are blocked by numerous bubbles. 2) Letal dose (DL100) H2O2 averages 5 +/- 2 mg 100 g-1 BW by subcutaneous route. Intraperitoneally, 60 mg 100 g-1 BW H2O2 are well tolerated, only 10% rats dying by emboli; 40 mg H2O2 injected in a gas pocket are also well tolerated. 3) Access of the blood stream of oxygen bubbles is limited by some anatomical peculiarities of the venous capillaries, notably hepatic sinusoids.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004618:Embolism, Air / Q000139:chemically induced*; D006861:Hydrogen Peroxide / Q000008:administration & dosage / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D011169:Portal Vein; D051381:Rats
D006861:Hydrogen Peroxide
Sur l'embolie gazeuse provoquée chez le rat par le peroxyde d'hydrogène.