title: Characterization of insulin biosynthesis and secretion of pancreatic islets prepared from hyperglycaemic sand rats. II. Investigations of islets after different periods of cultivation.
abstract: Cultivation of pancreatic islets of sand rats in the presence of high glucose led to a very high insulin release and to strongly diminished insulin contents independent of the metabolic stage of the sand rats. Changes in the [3H]-leucine incorporation into (pro)insulin were not found in dependence of cultivation.
mesh_terms: D000818:Animals; D003411:Arvicolinae; D002478:Cells, Cultured; D006943:Hyperglycemia / Q000378:metabolism*; D007328:Insulin / Q000096:biosynthesis / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D007700:Kinetics; D011384:Proinsulin / Q000096:biosynthesis
chemical_list: D007328:Insulin; D011384:Proinsulin