Immune and autoimmune aspects of diabetes mellitus.
The immune and autoimmune aspects of diabetes mellitus are reviewed. Emphasis is given to the clinical association of diabetes with other autoimmune disease; the increased incidence of organ-specific autoimmunity in diabetic patients; the occurrence of humoral and cell-mediated antipancreas (islet) autoimmunity in diabetes; the association of HLA with juvenile-onset, insulin-dependent diabetes mellitus and with certain specific subpopulations of diabetic patients; the possible role of viruses in the etiology of diabetes; and the occurrence of alterations in humoral and cell-mediated immunity, granulocyte function, and the host defense against infectious agents in human diabetics and in animals with experimental diabetes.
D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000150:complications; D001424:Bacterial Infections / Q000276:immunology; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000235:genetics / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D006098:Granulocytes / Q000473:pathology; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007328:Insulin / Q000276:immunology; D051379:Mice; D010179:Pancreas / Q000473:pathology; D014780:Viruses / Q000276:immunology
D001323:Autoantibodies; D006680:HLA Antigens; D007328:Insulin