Some aspects of the modulation and regulation of collagen synthesis in vitro.
We reviewed here a number of publications containing data on the quantitative aspects of collagen synthesis in vitro. In one section we discussed the factors which modulate the amount of collagen synthesized in various culture systems and in another section we presented experimental evidence for regulatory mechanisms operating in collagen synthesis on the transcriptional and/or translational levels. We believe that growing knowledge of the mechanisms controlling collagen synthesis will help us to understand and deal with fibrotic processes better.
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D002452:Cell Count; D002470:Cell Survival; D002478:Cells, Cultured; D002642:Chick Embryo; D003094:Collagen / Q000096:biosynthesis* / Q000378:metabolism; D003470:Culture Media; D006801:Humans; D009924:Organ Culture Techniques; D011347:Procollagen / Q000378:metabolism; D014176:Protein Biosynthesis; D051381:Rats; D014158:Transcription, Genetic
D003470:Culture Media; D011347:Procollagen; D003094:Collagen; D001205:Ascorbic Acid