[The dopaminergic system and aldosterone secretion. II. Effect of L-dopa and dexamethasone on aldosterone biosynthesis].
The authors studied the blood aldosterone, cortisol, and kalium levels, the plasma renin activity and the aldosterone urinary excretion following L-Dopa (0,50 g per os) administration in five patients affected by hypertension and six healthy control subjects, before and after the CRF-ACTH system suppression. The observed pattern shows that the aldosterone biosynthesis is inhibited also after the CRF-ACTH system has been suppressed. Therefore the authors conclude that the inhibiting action of L-Dopa on the aldosterone biosynthesis is mediated by the dopaminergic system stimulation.
D000328:Adult; D000450:Aldosterone / Q000096:biosynthesis* / Q000097:blood / Q000652:urine; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension / Q000188:drug therapy; D007980:Levodopa / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood
D007980:Levodopa; D000450:Aldosterone; D003907:Dexamethasone; D012083:Renin; D006854:Hydrocortisone
Sistema dopaminergico e secrezione di aldosterone. Nota II. Effetti della L-dopa e del desametazone sull'aldosteronogenesi.