Effects of physical training and food restriction on insulin secretion and glucose tolerance in male and female rats.
The purpose of this study was to assess the respective effects of physical training, adiposity, and total body mass on insulin secretion and glucose tolerance. Male and female rats were used in two separate studies. In a first study male rats were divided into three groups sedentary free-eating control (c), exercise-trained (T), and sedentary pair-weighted. In a second study with female rats, three groups were formed: C, T, and a sedentary food-restricted group. In the two studies, at the end of the training program, the animals were subjected to an intravenous insulin levels without any impairment of glucose tolerance. However, essentially the same results were obtained with both the pair-weighted male rats and the food-restricted female rats. These results suggest that the reduced levels of plasma insulin observed in trained rats challenged or not by a glucose load, could be explained by the reduction of body mass caused by exercise training.
D000273:Adipose Tissue / Q000033:anatomy & histology; D000818:Animals; D001835:Body Weight; D004032:Diet; D004822:Epididymis; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood*; D008297:Male; D010805:Physical Conditioning, Animal; D051381:Rats; D012737:Sex Factors; D014599:Uterus
D007328:Insulin; D005947:Glucose