Stimulation of insulin release by L-glutamine.
Under normal environmental conditions, L-glutamine is well oxidized but fails to stimulate insulin release in rat pancreatic islets. However, a marked stimulation of insulin release by L-glutamine, without alteration in its oxidation rate occurs when the intracellular pH of the islet cells is decreased and/or when theophylline is added to the incubation medium.
D000818:Animals; D005973:Glutamine / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013806:Theophylline / Q000494:pharmacology
D007328:Insulin; D005973:Glutamine; D013806:Theophylline