Mitogenic response to Toxocara antigen and chemotactic defect in visceral larva migrans.
A 3-year-old girl had the typical features of visceral larva migrans syndrome, including hypereosinophilia, recurrent pulmonary infiltrates, and elevated serum IgG, IgE, and isohemagglutinin titers. A marked mitogenic response of her cultured lymphocytes to Toxocara antigen but not to Ascaris antigen was found. A neutrophil chemotactic abnormality ot Escherichia coli culture filtrates and zymosan-activated sera was also demonstrated, which partially corrected after she was treated with diethylcarbamazine citrate.
D000941:Antigens; D002634:Chemotaxis, Leukocyte; D002675:Child, Preschool; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D006801:Humans; D007816:Larva Migrans, Visceral / Q000175:diagnosis* / Q000276:immunology; D008213:Lymphocyte Activation; D009504:Neutrophils; D014119:Toxocara / Q000276:immunology*
D000941:Antigens