[A comparison of the blood glucose increase and insulin requirement after oral sucrose, fructose and sorbitol alone or in combination (author's transl)].
The artificial pancreas allows a new means of quantification of the behaviour of blood glucose (BG) and insulin requirement after the administration of nutrient sweeteners such as fructose and sorbitol as compared to sucrose. The purpose of the present study was to compare the effects of these substances, plus a combination of fructose and sorbitol (70:30) in a group of maturity-onset diabetics. Sucrose produced the steepest BG increase and the greatest insulin requirement in order to return to baseline BG levels. Sorbitol at a dosage of 20 g did not act as a laxative, produced the smallest BG increase, and required the least amount of insulin to return to baseline. The combination of 70% fructose and 30% sorbitol achieved similar results to those of sorbitol alone, regarding both BG increase and amount of insulin required to return to baseline. Since this mixture has the same sweetening ability as sucrose, and shows no laxative effect, it was concluded that it is superior to fructose or sorbitol alone.
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000097:blood; D005260:Female; D005632:Fructose / Q000008:administration & dosage*; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013012:Sorbitol / Q000008:administration & dosage*; D013395:Sucrose / Q000008:administration & dosage*
D001786:Blood Glucose; D007328:Insulin; D005632:Fructose; D013012:Sorbitol; D013395:Sucrose
Vergleich des Blutglukoseanstiegs und des Insulin-bedarfs nach oralen Gaben von Saccharose, Fruktose, Sorbit oder einer Mischung Fruktose-Sorbit.