title: U-500 insulin in the treatment of antibody-mediated insulin resistance.
abstract: Three patients with antibody-mediated insulin resistance were treated with U-500 regular insulin subcutaneously. Insulin requirements decreased dramatically (55% to 75%) when therapy was changed from U-100 NPH pork to equivalent doses of U-500 regular pork insulin. There was no difference in antibody affinity for the insulin in these two preparations as shown by competition experiments. These observations demonstrate that U-500 insulin is a useful alternative in the treatment of antibody-mediated insulin resistance. The mechanism for this effect is yet to be determined.
mesh_terms: D000328:Adult; D000368:Aged; D000915:Antibody Affinity; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000276:immunology; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D007330:Insulin Antibodies / Q000276:immunology*; D007333:Insulin Resistance; D007336:Insulin, Isophane / Q000627:therapeutic use; D049528:Insulin, Long-Acting / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
chemical_list: D007328:Insulin; D007330:Insulin Antibodies; D049528:Insulin, Long-Acting; D007336:Insulin, Isophane