title: Role of the renin-angiotensin system in potassium control.
abstract: To determine the importance of the renin-angiotensin system in control of plasma potassium concentration and excretion, potassium control was studied in two groups of dogs in response to a 20-fold increase in sodium intake (from 10 to 200 meq/day). Group I was intact whereas group II lacked feedback control of the renin-angiotensin system, which was eliminated by continuous infusion of 10 ng . kg-1 . min-1 angiotensin II. This rate of infusion reduced endogenous plasma renin activity (PRA) to undetectable levels throughout the study. The sodium forcing did not result in measurable changes in plasma potassium concentration or excretion in group I, in which PRA fell to 40% and plasma aldosterone concentration (PAC) to 60% of the low sodium levels. In group II the same sodium forcing produced a 12% decrease in plasma potassium concentration and a 79% increase in urinary potassium excretion. PAC also fell to 60% of the low sodium level in group II. The results demonstrate the importance of the renin-angiotensin system as a link between the nephron and the zona glomerulosa that is essential in controlling plasma potassium concentration and excretion during changes in sodium balance.
mesh_terms: D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000494:pharmacology; D000809:Angiotensins / Q000502:physiology*; D000818:Animals; D004032:Diet; D004285:Dogs; D007668:Kidney / Q000502:physiology*; D008297:Male; D011188:Potassium / Q000097:blood / Q000502:physiology*; D012083:Renin / Q000097:blood / Q000502:physiology*; D012964:Sodium / Q000097:blood / Q000494:pharmacology
chemical_list: D000809:Angiotensins; D000804:Angiotensin II; D000450:Aldosterone; D012964:Sodium; D012083:Renin; D011188:Potassium