title: [Pharmacokinetic model studies of sulfamerazine in domestic mammals. 3. Acetylation, protein binding, and minimal inhibitory concentration of sulfamerazine].
abstract: Acetylation and protein fixation were established for the purpose of elucidating the chemotherapeutically effective part of sulphamerazine when applied to cattle, swine, horse, sheep, dog, and cat. The highest degree of acetylation and lowest protein fixation in all species tested, were recorded from swine. A reciprocal correlation was found to exist between the two above parameters, and it was statistically secured, except for horse. A mathematical description of the functional relationship between sulphamerazine fixed to serum protein and free sulphamerazine was possible by means of the Freundlich isothermia which had been recommended by SCHOLTAN (1962) in the following form: cgeb = K+ . cfreim The problem of minimum inhibitory concentration is discussed and explained in greater detail by computational examples with Escherichia coli.
mesh_terms: D000107:Acetylation; D000818:Animals; D000829:Animals, Domestic; D004926:Escherichia coli / Q000187:drug effects; D007700:Kinetics; D008322:Mammals / Q000097:blood*; D011485:Protein Binding; D013045:Species Specificity; D013416:Sulfamerazine / Q000097:blood* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D013416:Sulfamerazine
vernacular_title: Pharmakokinetische Modelluntersuchungen an Sulfamerazin bei Haussäugetieren. 3. Mitteilung: Azetylierung, Eiweissbindung und minimale Hemmkonzentration von Sulfamerazin.