Plaque-forming, antibody-dependent, cytotoxic cells with monocytic properties are present in rheumatoid synovial tissue.
Mononuclear cells eluted from synovial tissues from 16 patients with rheumatoid arthritis (RA) and 4 patients with juvenile rheumatoid arthritis (JRA) mediate cytotoxicity in vitro against a monolayer of sheep erythrocytes sensitized with IgG. Cell fractionation experiments suggested that most of the plaque-forming cells were non-lymphocytic and had adherence and phagocytic properties.
D000920:Antibody-Dependent Cell Cytotoxicity; D001171:Arthritis, Juvenile / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D009000:Monocytes / Q000276:immunology*; D013583:Synovial Membrane / Q000276:immunology* / Q000473:pathology