title: Escherichia coli K-12 clones that overproduce dam methylase are hypermutable.
abstract: A strain of Escherichia coli K-12 that overproduces dam methylase 50-fold was found to be hypermutable, and mutations which resulted in loss of excess methylase activity restored mutation frequencies to wild-type levels. These results are consistent with involvement of this deoxyribonucleic acid methylase in mismatch correction.
mesh_terms: D003001:Cloning, Molecular; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000378:metabolism*; D004260:DNA Repair; D004269:DNA, Bacterial / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics*; D008780:Methyltransferases / Q000378:metabolism*; D009154:Mutation
chemical_list: D004269:DNA, Bacterial; D008780:Methyltransferases; D004248:DNA (Cytosine-5-)-Methyltransferases