Host defenses in murine malaria: failure of vaccination with formolized blood parasites to protect athymic mice from Plasmodium berghei.
The thymus dependency of immunity to erythrocytic Plasmodium berghei (NYU-2) infection generated in response to injections of Formalin-killed mixed blood parasites was shown by the demonstration that the vaccine protected immunologically intact nu/+ mice, but not their athymic nu/nu littermates.
D000818:Animals; D004912:Erythrocytes / Q000469:parasitology; D008288:Malaria / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010962:Plasmodium berghei / Q000276:immunology*; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000008:administration & dosage
D014613:Vaccines, Attenuated