title: The long-term treatment with benzodiazepines: suggestions for further research.
abstract: While the effects of short-term benzodiazepine treatment have been extensively studied in several well-designed, controlled, clinical trials, further information is needed on the value and risks of anxiolytic drugs when administered over months to maintain chronic patients. Clinical trials on the effects of long-term benzodiazepine treatment present several methodological problems. The aim of this paper is to discuss these problems in relation to samples, drugs and dosage, duration, measures and experimental design.
mesh_terms: D001008:Anxiety Disorders / Q000188:drug therapy; D001569:Benzodiazepines / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D012107:Research Design / Q000592:standards
chemical_list: D001569:Benzodiazepines