[Inhibition of gluconeogenesis in the kidneys by a cytoplasmic regulator of mitochondrial membrane permeability].
Cytoplasmatic glycoprotein previously shown to be an inhibitor of mitochondrial membrane permeability for oxidation substrates inhibits in-vitro gluconeogenesis from pyruvate, lactate, succinate, alpha-ketoglutarate and glutamate in slices of the renal cortical layer. The inhibition was reduced with Ca2+ concentration increase in the incubation medium from 0.02 to 2 mM.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D003864:Depression, Chemical; D005943:Gluconeogenesis / Q000187:drug effects*; D006023:Glycoproteins / Q000008:administration & dosage / Q000096:biosynthesis / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D007672:Kidney Cortex / Q000378:metabolism*; D008099:Liver / Q000032:analysis*; D024101:Mitochondrial Proteins; D051381:Rats
D006023:Glycoproteins; D007328:Insulin; D024101:Mitochondrial Proteins; C031044:insulin-dependent cytoplasmic regulator protein, rat; D002118:Calcium
Tormozhenie gliukoneogeneza v pochkakh tsitoplazmaticheskim reguliatorom pronitsaemosti membrany mitokhondriĭ.