Reversible suppression of allo-antibody production by cyclosporin A.
Treatment of rats with 25 mg/kg/day of cyclosporin A suppressed their immune response to skin allografts. Withdrawal of cyclosporin A treatment led to complete recovery of specific immune responsiveness and the time taken for recovery was independent of the duration of treatment. Titration of the dose of cyclosporin A administered in vivo indicated that doses of 12 mg/kg/day or less were not fully immunosuppressive.
D000818:Animals; D003524:Cyclosporins; D004306:Dose-Response Relationship, Immunologic; D006085:Graft Survival / Q000187:drug effects; D007074:Immunoglobulin G; D007165:Immunosuppression Therapy; D007518:Isoantibodies / Q000096:biosynthesis*; D010456:Peptides, Cyclic / Q000494:pharmacology*; D051381:Rats; D016038:Skin Transplantation; D013997:Time Factors; D014184:Transplantation, Homologous
D003524:Cyclosporins; D007074:Immunoglobulin G; D007518:Isoantibodies; D010456:Peptides, Cyclic