Mutagenic and inhibitory properties of some new purine analogs on Salmonella typhimurium TA1530.
Mutagenic and growth-inhibitory effects of 2-amino-N6-hydroxyadenine, 2-amino-N6-methoxyadenine and 2-amino-N6-methyl-N6-hydroxyadenine were examined on S. typhimurium TA1530. All compounds showed strong mutagenic activity, and 2-amino-N6-hydroxyadenine induced mutations at a dose as low as 1 microgram/ml. 2-Amino-N6-hydroxyadenine and, to a lesser extent, 2-amino-N6-methyl-N6-hydroxyadenine (but not 2-amino-N6-methoxyadenine) exerted inhibitory effects on bacterial growth. The specificity of mutagenic action of these base analogs, as well as the target for reversion of the his- marker in TA1530, is discussed.
D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D009152:Mutagenicity Tests; D009153:Mutagens; D012486:Salmonella typhimurium / Q000235:genetics; D013329:Structure-Activity Relationship
D009153:Mutagens; C030633:2-amino-N(6)-methoxyadenine; C030634:2-amino-N(6)-methyl-N(6)-hydroxyadenine; C030632:2-amino-N(6)-hydroxyadenine; D000225:Adenine