title: 'Non-specific' binding of lac repressor of E. coli to a carcinogen-modified DNA.
abstract: The 'non-specific' binding of lac repressor to a N-hydroxyaminofluorene (N-OH-AF) modified DNA was studied using circular dichroism. The binding process was not altered by the modification of the DNA. A small increase of the binding constant was observed. These results are discussed with respect to the role of carcinogen modification in the protein-nucleic acid recognition phenomena.
mesh_terms: D002273:Carcinogens / Q000494:pharmacology; D004269:DNA, Bacterial / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism*; D005449:Fluorenes / Q000494:pharmacology; D006898:Hydroxylamines / Q000494:pharmacology; D012097:Repressor Proteins / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D002273:Carcinogens; D004269:DNA, Bacterial; D005449:Fluorenes; D006898:Hydroxylamines; D012097:Repressor Proteins; D014157:Transcription Factors; C001368:N-hydroxy-2-aminofluorene