Membranous glomerulopathy in a patient on captopril.
This case report describes a patient with essential hypertension in whom captopril during seven months resulted in a nephrotic syndrome. A renal biopsy specimen revealed membranous glomerulopathy stage I. After withdrawal of the drug, urinary protein loss disappeared within ten days. However, a second biopsy three months later still showed granular deposition of IgA, IgG, IgM and C3 in the glomerular basement membrane and unchanged subepithelial electron-dense deposits on electron microscopy. Glomerular filtration rate remained normal during the observation period.
D001706:Biopsy; D002216:Captopril / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D008875:Middle Aged; D011392:Proline / Q000031:analogs & derivatives*; D011507:Proteinuria / Q000139:chemically induced
D011392:Proline; D002216:Captopril