title: Candida endocarditis after heart valve replacement (successful management with reoperation and local disinfection).
abstract: Two patients with candida infection on prosthetic valves are presented. Both were eventually cured after removal of the prosthesis, sterilization of the prosthetic bed with local iodine solution (Sol. Iodi Aethanolica 6.5%) and insertion of a new prosthesis and the discontinuance of antifungal therapy. This technique has subsequently been applied to 22 patients with bacterial endocarditis with good results.
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001021:Aortic Valve / Q000601:surgery*; D002176:Candida albicans / Q000302:isolation & purification; D002177:Candidiasis / Q000175:diagnosis / Q000209:etiology*; D002675:Child, Preschool; D004202:Disinfectants / Q000008:administration & dosage* / Q000627:therapeutic use; D004696:Endocarditis / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D007455:Iodine / Q000008:administration & dosage; D008297:Male; D008943:Mitral Valve / Q000601:surgery*
chemical_list: D000935:Antifungal Agents; D004202:Disinfectants; D007455:Iodine