Fat inhibition of gastric acid secretion in duodenal ulcer patients before and after proximal gastric vagotomy.
In seven duodenal ulcer patients the effect of intraduodenal infusion of 20 ml oleic acid on submaximal gastric acid secretion stimulation by a continuous pentagastrin infusion was evaluated before and after proximal gastric vagotomy. In the control tests 20 ml of saline was given. Before vagotomy, oleic acid evoked a significant inhibition of gastric acid secretion of 25% compared with the controls. This inhibition was abolished after proximal gastric vagotomy. The difference in inhibition before and after vagotomy was significant (P=0.01). It is concluded that the vagus nerve in man plays a decisive role in duodenal fat inhibition of gastric acid secretion.
D000328:Adult; D003864:Depression, Chemical; D004381:Duodenal Ulcer / Q000503:physiopathology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009829:Oleic Acids / Q000494:pharmacology*; D010418:Pentagastrin / Q000494:pharmacology; D011184:Postoperative Period; D011300:Preoperative Care; D012636:Secretory Rate / Q000187:drug effects; D014628:Vagotomy; D014629:Vagotomy, Proximal Gastric
D007328:Insulin; D009829:Oleic Acids; D010418:Pentagastrin