Leukocyte abnormalities.
Certain qualitative abnormalities in neutrophils and blood monocytes are associated with frequent, severe, and recurrent bacterial infections leading to fatal sepsis, while other qualitative defects demonstrated in vitro may have few or no clinical sequelae. These qualitative defects are discussed in terms of the specific functions of locomotion, phagocytosis, degranulation, and bacterial killing.
D000199:Actins / Q000096:biosynthesis; D001770:Blood Bactericidal Activity; D002465:Cell Movement; D002609:Chediak-Higashi Syndrome / Q000097:blood; D002630:Chemotactic Factors / Q000096:biosynthesis; D003165:Complement System Proteins / Q000172:deficiency; D003594:Cytoplasmic Granules / Q000503:physiopathology; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood; D006105:Granulomatous Disease, Chronic / Q000097:blood; D006801:Humans; D007073:Immunoglobulin E; D007231:Infant, Newborn; D007962:Leukocytes / Q000503:physiopathology*; D009000:Monocytes / Q000503:physiopathology; D009504:Neutrophils / Q000503:physiopathology; D010100:Oxygen / Q000097:blood; D010586:Phagocytes / Q000502:physiology; D010587:Phagocytosis; D013577:Syndrome
D000199:Actins; D002630:Chemotactic Factors; D007073:Immunoglobulin E; D003165:Complement System Proteins; D010100:Oxygen