title: Hemoglobin A Ic and diabetes mellitus.
abstract: Hemoglobin A Ic is produced when glucose reacts nonenzymatically with the NH2-termini of Hb A beta chains and then undergoes an Amadori rearrangement. The concentration of Hb A Ic measured at any given time reflects a patient's mean blood glucose level for the preceding weeks to months. Infrequent measurements of Hb A Ic can therefore be used to assess long-term carbohydrate control in outpatient diabetics. In addition, the synthesis of Hb A Ic may represent a model reaction to explain the pathogenesis of many of the sequelae of chronic diabetes. Nonenzymatic glycosylation reactions may also underlie some of the changes ascribed to normal aging.
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006441:Hemoglobin A / Q000096:biosynthesis / Q000378:metabolism*; D006801:Humans; D008297:Male; D011247:Pregnancy
chemical_list: D001786:Blood Glucose; D006441:Hemoglobin A