Co-mutagenic effect of norharman with N-nitrosamine derivatives.
The mutagenicities of 14 nitrosamine compounds were tested on Salmonella typhimurium TA98 and TA100 in the presence of the co-mutagen norharman. N-Nitrosophenyl compounds, such as N,N-diphenylnitrosamine, N-methyl-N-phenylnitrosamine, N-ethyl-N-phenylnitrosamine and N-phenyl-N-benzylnitrosamine, were mutagenic when norharman was added to the incubation mixture, but not mutagenic in its absence. Norharman did not enhance the mutagenic activities of N-nitrosoaliphatic compounds.
D000470:Alkaloids / Q000494:pharmacology*; D002243:Carbolines; D004357:Drug Synergism; D006247:Harmine / Q000031:analogs & derivatives / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009153:Mutagens; D009602:Nitrosamines / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000235:genetics
D000470:Alkaloids; D002243:Carbolines; D009153:Mutagens; D009602:Nitrosamines; D006247:Harmine; C010262:norharman