DNA repair mechanisms and cytotoxicity of antitumour alkylating agents and neutral platinum complexes.
There are many indications that the cytotoxic action of a number of different antitumour agents, including chlorambucil and cis-platinum (II) diammine dichloride, is due to their ability to react with DNA and thereby inactivate it as a template for DNA replication. Moreover, the sensitivity of cells to these agents is related to their ability, either to remove the damage from DNA by some form of excision repair process, or to circumvent the lesions during DNA replication by so-called post-replication repair.
D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D002945:Cisplatin / Q000494:pharmacology*; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000096:biosynthesis / Q000235:genetics; D004260:DNA Repair; D004261:DNA Replication / Q000187:drug effects; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D007739:L Cells; D051379:Mice
D000477:Alkylating Agents; D004273:DNA, Neoplasm; D004247:DNA; D002945:Cisplatin