Sulfazecin and isosulfazecin, novel beta-lactam antibiotics of bacterial origin.
In the long history of screening for antibiotics, fungi and actinomycetes have been the only producers of beta-lactam antibiotics although several phytopathogenic bacteria have been reported to produce toxins with a beta-lactam structure. We report here the first evidence that novel monocyclic beta-lactam antibiotics, sulfazecin and isosulfazecin, are produced by new species of Pseudomonas.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D008997:Monobactams; D011549:Pseudomonas / Q000378:metabolism*; D047090:beta-Lactams / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D008997:Monobactams; D047090:beta-Lactams; C028547:sulfazecin