Erythrocyte G-6-PD and 6-PGD genetic polymorphisms in South African Negroes, with a note on G-6-PD and the malaria hypothesis.
Sample of 981 and 998 South African Negroes belonging to seven different ethnic groups were screened for G-6-PD and 6-PGD phenotypes, respectively. The results are discussed in terms of the interethnic variability and the possible adaptive values of these genetic polymorphisms. Particular attention is paid to the geographic co-distribution and interrelationship of G-6-PD deficiency and the occurrence of malaria in South Africa.
D044383:Black People; D004912:Erythrocytes / Q000201:enzymology; D005006:Ethnicity; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood / Q000235:genetics*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000453:epidemiology*; D006801:Humans; D008288:Malaria / Q000453:epidemiology*; D008297:Male; D010734:Phosphogluconate Dehydrogenase / Q000097:blood / Q000235:genetics*; D010963:Plasmodium falciparum; D011110:Polymorphism, Genetic; D013019:South Africa
D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase