Immune adsorption of anti-A and anti-B antibodies.
Plasma exchange is an effective technique for removal of antibodies prior to ABO incompatible marrow grafting. However, expense and hepatitis risk make alternative methods desirable. A solid phase immunoadsorbent column using blood group A trisaccharide has been demonstrated to specifically remove anti-A antibody from human plasma in vitro and immunized dogs in vivo with no toxicity. Preliminary results in patients are encouraging.
D000017:ABO Blood-Group System / Q000276:immunology*; D000741:Anemia, Aplastic / Q000628:therapy; D000818:Animals; D001787:Blood Group Incompatibility; D016026:Bone Marrow Transplantation; D004285:Dogs; D006084:Graft Rejection; D006086:Graft vs Host Disease / Q000517:prevention & control; D006650:Histocompatibility Testing; D006801:Humans; D007163:Immunosorbent Techniques; D007938:Leukemia / Q000628:therapy; D010951:Plasma Exchange; D014312:Trisaccharides
D000017:ABO Blood-Group System; D014312:Trisaccharides