The disulfiram (Antabuse)-Alcohol reaction in male alcoholics: its efficient management by 4-methylpyrazole.
4-methylpyrazole (4-MP), an inhibitor of alcohol dehydrogenase, rapidly abolished the accumulation of acetaldehyde following alcohol ingestion both in volunteers pretreated with the Antabuse analog calcium carbimide and in an antabuse-treated alcoholic. 4-MP also attenuated other typical symptoms, including facial flushing and tachycardia, thus suggesting its usefulness in the acute treatment of severe disulfiram-alcohol reactions.
D000328:Adult; D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors; D000437:Alcoholism / Q000534:rehabilitation*; D003484:Cyanamide / Q000009:adverse effects / Q000627:therapeutic use; D004221:Disulfiram / Q000009:adverse effects* / Q000627:therapeutic use; D000077604:Fomepizole; D006801:Humans; D008297:Male; D011720:Pyrazoles / Q000627:therapeutic use*
D011720:Pyrazoles; D003484:Cyanamide; D000077604:Fomepizole; D000429:Alcohol Oxidoreductases; D004221:Disulfiram