title: Preoperative and postoperative renin levels in coarctation of the aorta.
abstract: We studied plasma renin activity (PRA) in eight children before and after surgical correction of aortic coarctation. These eight children underwent a combination of low-sodium diet and diuresis before surgery, and PRA was measured shortly thereafter. Thirty-two to 51 months after successful surgical correction, PRA was measured again. The mean PRA was 21.4 +/- 1.3 ng/ml/hour (+/- SD) preoperatively and 5.5 +/- 1.5 ng/ml/hour postoperatively. These findings provide further evidence of the significance of increased renin-angiotensin activity in patients with aortic coarctation.
mesh_terms: D000293:Adolescent; D000804:Angiotensin II / Q000097:blood; D001017:Aortic Coarctation / Q000097:blood* / Q000150:complications / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D004039:Diet, Sodium-Restricted; D004232:Diuretics / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000150:complications; D012083:Renin / Q000097:blood*
chemical_list: D004232:Diuretics; D000804:Angiotensin II; D012083:Renin