title: Nifedipine in medically refractory angina pectoris.
abstract: Nifedipine was administered to 21 patients with angina pectoris which was refractory to conventional medication. In no case had coronary artery spasm been demonstrated. The condition of 13 patients (62%) improved with nifedipine, and eight patients (38%) had a long-term response. Nitrate-type side effects were reported by seven patients (33%), all of whom were being treated concurrently with isosorbide dinitrate. We conclude that nifedipine is a promising drug in the management of angina pectoris, even in the absence of documented coronary spasm.
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D000792:Angiography; D002986:Clinical Trials as Topic; D003971:Diastole / Q000187:drug effects; D004244:Dizziness / Q000139:chemically induced; D005260:Female; D006261:Headache / Q000139:chemically induced; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D010865:Pilot Projects; D011725:Pyridines / Q000627:therapeutic use*
chemical_list: D011725:Pyridines; D009543:Nifedipine