[Effect of cimetidine on lactose activity in patients with duodenal ulcer].
A significant decrease of the lactose levels (p less than .001) and of the glucose peaks after an overcharge of lactose (p less than .01) were found in 10 patients with duodenal ulcer after a treatment of 35 days with 1,2 daily grams of Cimetidine, when they were compared with a group treated with placebos. Also, a significant increase of the diarrhea associated with the overcharge of lactose (p less than .005) was obtained. The relation between the increase of the pH and the decrease of the lactose values was significant (r = 0,44 - p less than .01).
D002927:Cimetidine / Q000494:pharmacology* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000378:metabolism*; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D007785:Lactose / Q000378:metabolism*; D007789:Lactose Tolerance Test
D006146:Guanidines; D002927:Cimetidine; D007785:Lactose
Efecto de la cimetidina sobre la actividad de la lactasa en pacientes con úlcera duodenal.