S-antigens and isozymes in strains of Plasmodium falciparum.
Evidence was found for the independent reassortment of parasite genes for S-antigens and isozymes. The Lagos and Palo Alto strains of Plasmodium falciparum had the same isozyme forms of PGD and LDH but different S-antigens. In contrast, the BW (Gambia) and Palo Alto strains had different isozyme forms of GDH but shared some S-antigens. From artificial mixtures of parasites with different isozymes of GDH and different S-antigens, clones were derived in vitro which had a single isozyme type of GDH and a single type of S-antigen.
D000818:Animals; D000941:Antigens / Q000032:analysis; D001029:Aotus trivirgatus; D002999:Clone Cells; D004591:Electrophoresis, Polyacrylamide Gel; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D010963:Plasmodium falciparum / Q000201:enzymology / Q000235:genetics* / Q000276:immunology
D000941:Antigens; D007527:Isoenzymes; D005969:Glutamate Dehydrogenase