title: 'Nephrotoxicity' and metabolic acidosis in transplant patients on cyclosporin A.
abstract: Renal function, as represented by serum creatinine and creatinine clearance, 18 to 24 months after renal transplantation was studied in 21 patients receiving Cyclosporin A and compared with that of 25 patients on corticosteroids and azathioprine. Although renal function at six months post transplantation was significantly poorer in those patients on Cyclosporin A compared with those on conventional therapy, it did not deteriorate with time. No significant alteration in renal function was observed in five hepatic transplant recipients on Cyclosporin A after three months. Lower serum bicarbonate was observed more frequently in those renal transplant recipients on Cyclosporin A than in those on conventional therapy, reflecting possible tubular damage.
mesh_terms: D000138:Acidosis / Q000097:blood / Q000139:chemically induced*; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D001639:Bicarbonates / Q000097:blood; D003404:Creatinine / Q000097:blood; D003524:Cyclosporins / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced*; D016030:Kidney Transplantation; D008297:Male; D011188:Potassium / Q000097:blood
chemical_list: D000305:Adrenal Cortex Hormones; D001639:Bicarbonates; D003524:Cyclosporins; D003404:Creatinine; D001379:Azathioprine; D011188:Potassium