Enhanced peripheral glucose utilization and suppressed hepatic glycogen synthesis in KK mice treated with islet-activating protein (IAP).
Effect of islet-activating protein (IAP) on glucose utilization of peripheral tissues and glycogen synthesis of the liver was investigated in diabetic KK mice. The 14C-content of diaphragm glycogen following the injection of [U-14C] glucose was much less in KK mice than in dd/Y mice, and it was restored to normal in KK mice treated with IAP. The enhanced glucose utilization in these mice was completely abolished by the injection of anti-insulin serum. Glycogen synthesis of the liver after glucose load was also less in KK mice than in dd/Y mice, and it was clearly suppressed in both groups of mice by IAP treatment. It was concluded that improved glucose tolerance of IAP-treated KK mice was mostly due to enhanced glucose utilization of peripheral tissues secondary to increased insulin secretion induced by IAP injection.
D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D001426:Bacterial Proteins / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D005947:Glucose / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D008112:Liver Glycogen / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D037342:Pertussis Toxin; D013268:Stimulation, Chemical; D013997:Time Factors; D010566:Virulence Factors, Bordetella
D001426:Bacterial Proteins; D001786:Blood Glucose; D007328:Insulin; D008112:Liver Glycogen; D010566:Virulence Factors, Bordetella; D037342:Pertussis Toxin; D005947:Glucose