Mutagenicity of three aromatic amines in the presence of fractions from various tissues.
The mutagenic activity of 2-aminofluorene, 4-aminobiphenyl and 3,2'-dimethylaminobiphenyl towards Salmonella typhimurium strain TA1538 was tested in the presence of post-mitochondrial fractions of liver, kidney, intestine, colon and testicle from untreated and pretreated rats. The metabolic activation capacity of these various fractions was very different. In the experimental conditions, no relationship was found between the mutagenic activity and the carcinogenicity of the three aromatic amines.
D000611:Aminobiphenyl Compounds / Q000633:toxicity*; D000814:Aniline Compounds / Q000633:toxicity*; D000818:Animals; D001711:Biotransformation; D004159:Diphenylamine / Q000031:analogs & derivatives / Q000633:toxicity*; D005449:Fluorenes / Q000633:toxicity*; D066298:In Vitro Techniques; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000235:genetics; D013347:Subcellular Fractions / Q000378:metabolism
D000611:Aminobiphenyl Compounds; D000814:Aniline Compounds; D005449:Fluorenes; D009153:Mutagens; C001042:2',3-dimethyl-4-aminobiphenyl; C006757:4-biphenylamine; C012177:2-aminofluorene; D004159:Diphenylamine