Body-fluid composition in normal and hypertensive man.
1. Erythrocyte mass, plasma volume (PV), extracellular fluid volume (ECFV) and total body water were simultaneously measured in 30 normotensive and 30 normal-renin hypertensive Caucasian male subjects for accurate determination of the presence or absence of a disorder(s) in body-fluid composition in hypertension. 2. The results indicate that plasma volume and total blood volume are lower in hypertensive subjects than in normotensive control subjects. The PV comprised 19% of the ECFV in both control and hypertensive subjects. 3. ECFV was lower in hypertensive subjects than in normotensive control subjects; the PV and interstitial fluid components of the ECFV were reduced by similar proportions. The ECFV, furthermore, comprised a smaller portion of the total body water in hypertensive subjects than that in control subjects. 4. We conclude that in the hypertensive state there is a reduction in the ECFV, but that there is no change in the partition of the ECFV between the plasma and interstitial components.
D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood; D001826:Body Fluids / Q000378:metabolism*; D001834:Body Water / Q000378:metabolism; D004911:Erythrocyte Volume; D005110:Extracellular Space / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010953:Plasma Volume; D012083:Renin / Q000097:blood
D000450:Aldosterone; D012083:Renin