title: Metabolic activation and toxicology - some models of chemical protection against drug toxicity.
abstract: This article describes some examples concerning the mechanism involved in the drug toxicity mediated by the enzymes of metabolism. They concern the production of various reactive metabolites which strongly bind to biological macromolecules inducing different forms of toxicity (necrosis, mutations and cancers). Some recent data on the field of protection and prevention means against the hepatoxicity of carcinogenesis are described.
mesh_terms: D000082:Acetaminophen / Q000633:toxicity; D000818:Animals; D001711:Biotransformation; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D002725:Chloroform / Q000633:toxicity; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004336:Drug Antagonism; D064420:Drug-Related Side Effects and Adverse Reactions; D008954:Models, Biological; D011083:Polycyclic Compounds / Q000633:toxicity
chemical_list: D011083:Polycyclic Compounds; D000082:Acetaminophen; D002725:Chloroform; D003577:Cytochrome P-450 Enzyme System