Localization of neuronal histamine in rat brain.
Antisera to histamine were generated by immunization of albino guinea pigs with a complex of histamine and methylated-bovine serum albumin. Characterization of the antisera and preliminary mapping of histaminergic neurons were conducted on brain tissue from normal and experimentally manipulated rats. Using immunofluorescence, histamine-like immunoreactive cell bodies were revealed in the lateral hypothalamus, and fibers were stained in the hypothalamus, cortex, amygdala and hippocampus.
D000679:Amygdala / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D005260:Female; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D006624:Hippocampus / Q000378:metabolism; D006632:Histamine / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism; D008473:Median Eminence / Q000378:metabolism; D009412:Nerve Fibers / Q000378:metabolism; D009474:Neurons / Q000378:metabolism
D006632:Histamine