Dissociation of antipolyuric action and increase in plasma renin activity caused by chlorothiazide in Brattleboro rats.
The previous finding that chlorothiazide (about 250 mg/day) induces a sustained reduction in the polyuria of homozygous Brattleboro (BB) female rats, as well as an increase to about 250% of plasma renin activity was confirmed. Disruption of the renin-angiotensin system by either the angiotensin antagonist saralasin or the beta-blocking agent propranolol does not interfere with chlorothiazide antidiuresis. Each inhibitor reduces BB polyuria on its own, an effect which, however, may be explained by a possible interference with thirst.
D000818:Animals; D002740:Chlorothiazide / Q000494:pharmacology*; D003404:Creatinine / Q000097:blood; D003919:Diabetes Insipidus / Q000201:enzymology / Q000503:physiopathology*; D004326:Drinking / Q000187:drug effects; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects; D005260:Female; D009994:Osmolar Concentration; D011141:Polyuria / Q000517:prevention & control*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D012083:Renin / Q000097:blood*; D012504:Saralasin / Q000494:pharmacology
D002740:Chlorothiazide; D011433:Propranolol; D003404:Creatinine; D012083:Renin; D012504:Saralasin