Aggressive behavior in mice provokes a marked increase in both plasma epidermal growth factor and renin.
The plasma concentration of epidermal growth factor (EGF) in normal, nephrectomized and sialectomized mice is about 0.5 nmol/l. Aggressive behaviour results in a parallel increase in both plasma EGF and plasma renin for both normal and nephrectomized mice. The plasma concentration of EGF increases around 300- and 150-fold respectively; no increase is observed in sialectomized mice, suggesting that the submaxillary gland is an important source of liberated EGF. Virtually all the EGF is found in plasma as a low molecular species that behaves as pure EGF, when examined by radioimmuno- and radioreceptor assays.
D000374:Aggression; D000818:Animals; D002850:Chromatography, Gel; D004815:Epidermal Growth Factor / Q000097:blood*; D006801:Humans; D008297:Male; D051379:Mice; D009392:Nephrectomy; D012083:Renin / Q000097:blood*; D013363:Submandibular Gland / Q000502:physiology
D004815:Epidermal Growth Factor; D012083:Renin