Effect of infused captopril on blood pressure and the renin-angiotensin-aldosterone system in normal dogs subjected to varying sodium balance.
Infusion of captopril at 20, 200, 2,000 and 6,000 micrograms/kg/hour into sodium-depleted conscious dogs produced a rapid, dose-dependent decrease in blood pressure and plasma angiotensin II and III, maximal suppression being achieved at 200 micrograms/kg/hour (97 +/- 14 to 65 +/- 8 [standard deviation] mm Hg, 38 +/- 10.6 to 3.2 +/- 1.5 pmol/liter and 7.0 +/- 4.8 to 1 +/- 0.5 pmol/liter, respectively). Angiotensin I concentration increased with each infusion rate to a maximal 16-fold increase at 6,000 micrograms/kg/hour (26 to 416 pmol/liter). For all infusion rates the percentage decrease in blood pressure correlated with the percentage decrease in plasma angiotensin II (r = 0.65, p less than 0.001). Infusion of captopril at 6,000 micrograms/kg/hour into sodium-loaded dogs also produced a decrease in both blood pressure (117 +/- 9 to 96.6 +/- 11 mm Hg) and plasma angiotension II (11.0 +/- 3 to 1.6 +/- 1.3 pmol/liter). Plasma aldosterone concentrations decreased whereas both blood angiotensin I and renin concentration increased. In another experiment angiotensin II was infused at 2, 6, 18 and 54 ng/kg/min into sodium-depleted dogs firstly without modification and secondly combined with captopril (6,000 micrograms/kg/hour) given for 1 hour before the angiotensin dose-response study and continued throughout. Angiotensin II infusion raised mean arterial pressure and plasma angiotensin II in each animal. However, the angiotensin II blood pressure dose-response curve was shifted downwards and to the right in the captopril-treated animals. These results suggest that arterial pressure and aldosterone secretion in normal dogs are partly dependent on the renin-angiotensin system but that not all of the acute decrease in blood pressure produced by captopril can be explained by the suppression of the acute vasoconstrictor effect of circulating angiotensin II.
D000803:Angiotensin I / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D000805:Angiotensin III / Q000097:blood; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D008297:Male; D011392:Proline / Q000031:analogs & derivatives*; D012084:Renin-Angiotensin System / Q000187:drug effects*; D014661:Vasoconstriction / Q000187:drug effects; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D000804:Angiotensin II; D000805:Angiotensin III; D000803:Angiotensin I; D011392:Proline; D002216:Captopril