title: A mutant inducible for galactitol utilization in Escherichia coli K12.
abstract: Galactitol-positive strains of Escherichia coli K12 are inhibited by the galactitol analogues L-fucitol and 2-deoxy-D-galactitol, but not by D-fucitol; Salmonella typhimurium LT2 is not inhibited by these compounds. Most mutants selected as resistant to either toxic compound are unable to utilize galactitol as carbon source, but a relatively rare class is inducible for the Enzyme II of the galactitol:phosphoenolpyruvate phosphotransferase system, the product of which is D-galactitol 6-phosphate. The lesion in one such mutant maps near metG at about min 45 on the E. coli genome.
mesh_terms: D002874:Chromosome Mapping; D002876:Chromosomes, Bacterial; D004790:Enzyme Induction; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D004376:Galactitol / Q000378:metabolism*; D005798:Genes, Bacterial; D008040:Genetic Linkage; D009154:Mutation; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System / Q000096:biosynthesis; D013402:Sugar Alcohols / Q000378:metabolism*
chemical_list: D013402:Sugar Alcohols; D004376:Galactitol; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System; C034465:phosphoenolpyruvate-galactitol phosphotransferase