title: An assay for mutagenic activity of 4CMB, 4HMB and BC, using the "microtitre" fluctuation test.
abstract: 4CMB, 4HMB and BC were assayed for mutagenic activity using the 'microtitre' bacterial fluctuation test without metabolic activation. 4CMB was positive in strains of Salmonella typhimurium detecting both base-substitution and frameshift mutation. BC was weakly positive only in the strain which detects base-substitution mutation. 4HMB was negative in both strains. 4CMB and 4HMB were equally toxic to the strains, whilst BC was comparatively less toxic.
mesh_terms: D001593:Benzyl Compounds / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D012486:Salmonella typhimurium / Q000187:drug effects; D013045:Species Specificity; D013329:Structure-Activity Relationship
chemical_list: D001593:Benzyl Compounds; D001713:Biphenyl Compounds; D009153:Mutagens; C033488:4-hydroxymethylbiphenyl; C033487:4-chloromethylbiphenyl; C021292:benzyl chloride