Pathological changes in inbred strains of mice following early thymectomy and irradiation.
Mice subjected to thymectomy and irradiation were found to develop a range of pathological change in various organs. These changes were accompanied by antibodies to a variety of self-components. The pattern of pathological and autoimmune change was found to vary with the strain. This strain-related expression did not appear to be associated with the major histocompatibility complex (H-2).
D000818:Animals; D005455:Fluorescent Antibody Technique; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains / Q000502:physiology*; D011830:Radiation Effects; D013045:Species Specificity; D013934:Thymectomy; D013961:Thyroid Gland / Q000473:pathology