Chromatography in studies of quantitative structure-activity relationships.
The rational bases, experimental techniques and conditions required for the chromatographic determination of the structural data of importance for studies on quantitative relationships between chemical structure and biological activity of drugs (QSAR) are reviewed. Practical applications of the information gathered from various chromatographic modes in correlation with bioactivity data are discussed.
D000818:Animals; D001682:Biological Availability; D002845:Chromatography / Q000379:methods*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism; D013329:Structure-Activity Relationship
D004364:Pharmaceutical Preparations