Influence of liver S-9 preparations from rats and rainbow trout on the activity of four mutagens.
The mutagenicity of four chemical compounds to strain TA100 of S. typhimurium was affected differently by liver S-9 preparations from untreated Sprague-Dawley rats and from rainbow trout (Salmogairdneri). These two species were equally effective in decreasing the direct mutagenicity of sodium dichromate. Rat preparations were totally inactive and trout preparations were slightly active in producing mutagenic metabolites from benzo(a)pyrene (BP). Conversely, rat homogenates were significantly more efficient in activating aflatoxin B1 (AFB1) and, in particular, 2-aminofluorene (2-AF).
D000818:Animals; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism; D009153:Mutagens / Q000378:metabolism*; D009154:Mutation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000235:genetics; D012487:Salmonidae / Q000378:metabolism*; D013347:Subcellular Fractions / Q000378:metabolism*; D014337:Trout / Q000378:metabolism*
D009153:Mutagens