Immunochemical and cytotoxic activities of Shigella dysenteriae 1 (shiga) and shiga-like toxins.
Toxins in culture supernatants and bacterial lysates of S. dysenteriae 1 and S. flexneri were quantitated by a cytotoxicity assay and a newly developed radioimmunoassay. Cytotoxin titers paralleled toxin antigen levels. Thus, variations in cytotoxicity among shigellae probably reflect differences in toxin yield rather than specific activity (cytotoxicity per microgram of toxin antigen).
D001427:Bacterial Toxins / Q000032:analysis / Q000096:biosynthesis / Q000633:toxicity*; D006367:HeLa Cells; D011863:Radioimmunoassay; D022603:Shiga Toxins; D012762:Shigella dysenteriae / Q000378:metabolism
D001427:Bacterial Toxins; D022603:Shiga Toxins