title: Chlorpromazine and propranolol extend survival of infant mice inoculated with enterotoxigenic Escherichia coli.
abstract: Effects of chlorpromazine and propranolol were tested in infant mice model of Enterotoxigenic Escherichia coli diarrhea. Reference strain B41 inoculated orally from 18 h to 48 h after birth causes death of almost all animals in less than 48 h. Both drugs, which are known to reverse submaximal induced secretion by heat-stable toxin in the suckling mouse assay, used as single treatment, were able to extend the survival of mice.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002746:Chlorpromazine / Q000008:administration & dosage / Q000627:therapeutic use*; D003967:Diarrhea / Q000188:drug therapy / Q000401:mortality; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000401:mortality; D007279:Injections, Subcutaneous; D051379:Mice; D008815:Mice, Inbred Strains; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D011433:Propranolol; D002746:Chlorpromazine