Nonprotein neurotoxins.
Nonprotein neurotoxins are continuing to play a major role as molecular probes in studying nervous processes. They also have clinical importance as some of them, such as saxitoxin and its analogues, are the source of public health problems, or have potential use in therapy. This review covers clinical, biological, pharmacological, and chemical aspects of certain nonprotein neurotoxins, with emphasis on three well-known ones: tetrodotoxin, saxitoxin, and batrachotoxin. The distribution of the toxins is discussed as well as their symptomatology, treatment of affected patients, and effects of their structures on their physiological activity. With so many outstanding problems remaining in neuropharmacology, the study of nonprotein neurotoxins thrives as a fertile area of research.
D000818:Animals; D001496:Batrachotoxins / Q000633:toxicity*; D005075:Biological Evolution; D002462:Cell Membrane / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D008970:Molecular Weight; D009498:Neurotoxins / Q000633:toxicity*; D012119:Respiration / Q000187:drug effects; D012530:Saxitoxin / Q000633:toxicity*; D013045:Species Specificity; D013329:Structure-Activity Relationship; D013779:Tetrodotoxin / Q000494:pharmacology / Q000633:toxicity*
D001496:Batrachotoxins; D009498:Neurotoxins; D012530:Saxitoxin; D013779:Tetrodotoxin