High-dose AMSA and bone marrow rescue in patients with solid tumors.
The feasibility of high-dose AMSA followed by autologous bone marrow rescue was studied in seven patients with solid tumors. They received a total of 12 courses of treatment. Total doses ranged from 600 to 1000 mg/m2/course. Major toxic effects were myelosuppression, fever of unknown origin, and stomatitis. One patient with malignant melanoma had stable disease lasting 2 months; the other six had progressive disease.
D000609:Aminoacridines / Q000008:administration & dosage* / Q000009:adverse effects; D000677:Amsacrine; D001853:Bone Marrow / Q000187:drug effects; D016026:Bone Marrow Transplantation; D006801:Humans; D009369:Neoplasms / Q000628:therapy*
D000609:Aminoacridines; D000677:Amsacrine