Captopril(SQ 14,225): in vitro and in vivo influence on the proliferative response of rat lymphocytes.
Captopril in vitro (50-500 micrograms/ml) increased 3H-TdR incorporation in unstimulated and mitogen-stimulated cultures of rat lymphocytes. Unseparated spleen and lymph node cells of rats orally treated with captopril (50 mg/kg/day x 4)) showed decreased basal and mitogen stimulated 3H-TdR incorporation. The removal of macrophages abrogated this inhibitory effect. Leucine aminopeptidase activity of macrophages was reduced - in vivo and in vitro - by captopril.
D000818:Animals; D002216:Captopril / Q000494:pharmacology*; D003208:Concanavalin A; D007931:Leucyl Aminopeptidase / Q000378:metabolism; D008070:Lipopolysaccharides; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology; D011392:Proline / Q000031:analogs & derivatives*; D051381:Rats; D011917:Rats, Inbred Lew
D008070:Lipopolysaccharides; D003208:Concanavalin A; D011392:Proline; D002216:Captopril; D007931:Leucyl Aminopeptidase