[Antibiotic prophylaxis in elective colon surgery: comparison of the combination of metronidazole (Flagyl)/cefazolin (Kefzol) with cefazolin alone].
In this prospective trial prevention of infectious complications after elective colonic surgery was studied. 34 patients receiving i.v. cefazolin were compared to 32 patients receiving oral metronidazol and i.v. cefazolin. No significant difference was observed concerning local wound infection, septicemia, anastomotic dehiscence or death. The rate of postoperative infection was 53% in group I, 34% in group II. No side effects of this prophylaxis were observed.
D000368:Aged; D002437:Cefazolin / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003106:Colon / Q000601:surgery*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D011897:Random Allocation; D013530:Surgical Wound Infection / Q000517:prevention & control*
D008795:Metronidazole; D002437:Cefazolin
Antibiotikaprophylaxe in der elektiven Kolonchirurgie: Vergleich der Kombination Metronidazol (Flagyl)/Cefazolin (Kefzol) mit Cefazolin allein.