Autoimmune anti-glomerular basement membrane glomerulonephritis induced with isologous renal antigen in rats.
In an attempt to reproduce "glycoprotein nephritis", nephritogenic glycoprotein or glycopeptides were prepared from isologous renal cortices by the method of Shibata et al. Rats of Wistar Imamichi that were given a single injection with glycoprotein or glycopeptides in incomplete Freund's adjuvant (IFA) to the hind footpads developed glomerulonephritis. Light microscopic findings were essentially similar to those in their reports. However, in spite of similar materials and methods as they used, immunofluorescent findings were entirely different; localization of rat IgG and complement showed a "linear pattern" in contrast to their "mesangial pattern." Linear pattern in immunofluorescent study supports a notion that we succeeded in induction of autoimmune anti-glomerular basement membrane glomerulonephritis (Steblay's type nephritis) by immunization with isologous renal antigen.
D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D001327:Autoimmune Diseases / Q000209:etiology*; D001485:Basement Membrane / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D006020:Glycopeptides; D006023:Glycoproteins; D007668:Kidney / Q000276:immunology*; D007678:Kidney Glomerulus / Q000276:immunology*; D008297:Male; D051381:Rats
D000941:Antigens; D006020:Glycopeptides; D006023:Glycoproteins