Evidence of H-Y antigen on human B lymphocytes.
H-Y antigen was studied in human peripheral blood lymphocytes from male and female subjects by indirect immunofluorescence. In males, 20% of lymphocytes were found to be H-Y+, compared with 9% in females. B- and T-cell-enrichment analysis showed a close correlation between the male B-lymphocyte count and the H-Y+-cell count. The method described is particularly applicable to the measurement of H-Y antigen in cases of ambiguous sex differentiation since it offers direct demonstration of H-Y antigen in the cells of the individual under examination.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006182:H-Y Antigen / Q000032:analysis*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology; D008297:Male; D051379:Mice; D012737:Sex Factors
D006182:H-Y Antigen