title: Hemodynamic effects of systemic or portal IV infusion of live E coli bacteria in the cat. A preliminary report.
abstract: The reactions in the series-coupled vascular sections of the small intestine and the changes in aortic blood flow, systemic arterial, and pulmonary arterial blood pressure were followed continuously in cats made septic by IV infusion of live E coli bacteria for 2 hours. Peripheral venous infusion initially induced systemic hypotension, pulmonary hypertension, and increased aortic blood flow, but decreased intestinal blood flow. These changes were normalized within 5-10 minutes. During the next 110 minutes systemic arterial blood pressure, aortic blood flow, and intestinal blood flow decreased continuously while intestinal blood flow resistance remained in the control range. Portal venous infusion induced a significantly less pronounced initial pulmonary arterial blood pressure increase. No initial intestinal vasoconstriction was noticed and intestinal blood flow resistance decreased during the bacterial infusion. In both series only small and insignificant changes of intestinal tissue volume were seen. The data suggest that the route of infusion is important to the response in experimentally-induced sepsis. The constant intestinal tissue volume argues against intestinal pooling as being of importance to the development of low blood pressure in septic shock.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume; D002415:Cats; D004927:Escherichia coli Infections / Q000503:physiopathology*; D005268:Femoral Vein; D006439:Hemodynamics; D007263:Infusions, Parenteral; D007422:Intestines / Q000098:blood supply; D011169:Portal Vein; D012039:Regional Blood Flow; D018805:Sepsis / Q000503:physiopathology*; D014655:Vascular Resistance; D014690:Venous Pressure