Liposome accumulation in ischaemic intestine following experimental mesenteric occlusion.
Partial intestinal ischaemia was produced by ligation of selected primary laterals of the mesenteric artery in the rat. Both positively and negatively charged liposomes (multiply labelled with [99mTc]diethylenetriamine pentaacetic acid, [3H]methoxy-inulin, and [4-14C]-cholesterol), administered 24 h following ligation, were accumulated in ischemic (necrotic) intestine.
D000818:Animals; D002784:Cholesterol; D007421:Intestine, Small / Q000098:blood supply*; D007444:Inulin; D007511:Ischemia / Q000378:metabolism*; D008026:Ligation; D008081:Liposomes / Q000378:metabolism*; D008638:Mesenteric Arteries; D008641:Mesenteric Vascular Occlusion / Q000378:metabolism; D004369:Pentetic Acid; D051381:Rats; D012039:Regional Blood Flow; D013667:Technetium; D016284:Technetium Tc 99m Pentetate
D008081:Liposomes; D013667:Technetium; D004369:Pentetic Acid; D007444:Inulin; D002784:Cholesterol; D016284:Technetium Tc 99m Pentetate