title: Activity of the combination of isoniazid, protionamide and dapsone against Mycobacterium leprae and some other mycobacteria.
abstract: No additive effect was found at the addition of isoniazid to either dapsone or protionamide against M. leprae and against highly dapsone-sensitive in vitro growing Mycobacterium sp. strains. It is concluded that the indication of the administration of isoniazid in leprosy is extremely limited and could only be envisaged as a companion drug in combined therapy of dapsone-resistant multibacillary leprosy in light-skinned people, when aminoglycosides cannot be administered.
mesh_terms: D000818:Animals; D003622:Dapsone / Q000627:therapeutic use*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D007538:Isoniazid / Q000627:therapeutic use*; D007539:Isonicotinic Acids / Q000627:therapeutic use*; D007918:Leprosy / Q000188:drug therapy*; D051379:Mice; D009161:Mycobacterium / Q000187:drug effects; D009166:Mycobacterium leprae / Q000187:drug effects; D011515:Prothionamide / Q000627:therapeutic use*
chemical_list: D007539:Isonicotinic Acids; D011515:Prothionamide; D003622:Dapsone; D007538:Isoniazid