title: Speculations on the mechanism of action of hallucinogenic indolealkylamines.
abstract: In this review we attempt to develop a fluid theoretical model which is being used as a strategy-base for future experimentation. The first two sections (A and B) describe how we have conducted our research, and present the perspective value of each. This is important because the research strategies developed in these laboratories over the last 5 years combine in vitro and in vivo pharmacological techniques as a means of understanding mechanisms of drug action. Sections C and D attempt to describe how we interpret our data and how we have utilized these data to formulate hypotheses concerning drug mechanisms. The last section of this review sets forth our own ideas on how we believe hallucinogenic agents produce their effects and presents some original data, which we feel, allows us to develop the overall hypotheses presented.
mesh_terms: D000818:Animals; D001519:Behavior / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004193:Discrimination Learning; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004351:Drug Resistance; D006213:Hallucinogens / Q000494:pharmacology*; D006801:Humans; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology; D051379:Mice; D008962:Models, Theoretical; D009434:Neural Pathways / Q000187:drug effects; D010643:Phenoxybenzamine / Q000494:pharmacology; D011903:Raphe Nuclei / Q000187:drug effects; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism; D013329:Structure-Activity Relationship; D014363:Tryptamines / Q000494:pharmacology*
chemical_list: D006213:Hallucinogens; D011985:Receptors, Serotonin; D014363:Tryptamines; D010643:Phenoxybenzamine; D012701:Serotonin; D008238:Lysergic Acid Diethylamide