title: Absence of endotoxin fever but not prostaglandin E2 fever in the Brattleboro rat.
abstract: Changes in colonic temperature following intracerebroventricular injection (icv) of bacterial endotoxin or prostaglandin E2 (PGE2) were measured in Long-Evans (LE) and Brattleboro (DI) rats. Indwelling cannulas were implanted into the brains of rats for subsequent microinjection into a lateral cerebral ventricle. Microinjection of 1 microgram of bacterial endotoxin into a lateral cerebral ventricle produced a fever in the LE rat but not in the DI rat. Daily injections of 1 microgram of endotoxin icv in the DI rat did not result in a fever. Intraperitoneal injections of 50 micrograms of bacterial endotoxin resulted in a fever in the LE rat, but the DI rat showed no such response. Both groups of animals did produce a fever in response to icv administration of 200 ng of PGE2. The lack of arginine vasopressin in the DI rat may be related to the animal's failure to show a febrile response to endotoxin.
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D015232:Dinoprostone; D004731:Endotoxins; D004926:Escherichia coli; D005334:Fever / Q000139:chemically induced*; D008297:Male; D011458:Prostaglandins E; D011749:Pyrogens; D051381:Rats; D012475:Salmonella
chemical_list: D004731:Endotoxins; D011458:Prostaglandins E; D011749:Pyrogens; D015232:Dinoprostone