Synthesis of unnatural P-N-bond catalyzed with E. coli ribosomes.
The model substances 2'(3')-O-[N-acetylmethionylaminomethylene-(P-methyl)phosphino] ester of adenosine-5'-phosphate, pA-(AcMetGlyP), and N-acetylmethionylaminomethylene-(P-methyl) phosphinoamide of phenylalanine, AcMetGly P PheOH, were synthesised. They were used for the ribosomal catalysis studying.
D000249:Adenosine Monophosphate / Q000031:analogs & derivatives*; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000378:metabolism*; D010649:Phenylalanine / Q000031:analogs & derivatives*; D012270:Ribosomes / Q000187:drug effects / Q000378:metabolism*
D000249:Adenosine Monophosphate; D010649:Phenylalanine