title: [Crosti disease (reticulohistiocytoma type Crosti). Light microscopic, ultrastructural, histochemical and immunohistologic findings].
abstract: Four patients with lymphoma-like skin diseases of a protracted course and dubious dignity are reported and reviewed together with similar cases of the literature. These cases correspond largely to the entity termed reticulohistiocytoma which was described by Crosti in 1951. The ultrastructural, histochemical, and immunohistological findings indicate tha the tumoral infiltrate consists of a cell population with close similarities to histiocytes. A possible explanation for the characteristic protracted evolution is an immunologic mechanism is causing an increased cell death rate.
mesh_terms: D005350:Fibroma / Q000648:ultrastructure*; D005455:Fluorescent Antibody Technique; D006644:Histiocytes / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D012867:Skin / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000648:ultrastructure*
vernacular_title: Morbus Crosti (Retikulohistiozytom Typ Crosti). Lichtmikroskopische, ultrastrukturelle, histochemische und immunhistologische Befunde.