Continuous treatment with natural oestrogens and progestogens. A method to avoid endometrial stimulation.
Treatment of menopausal symptoms with a combination of natural oestrogens (17beta-oestradiol and oestriol) and a gestagen (norethisterone acetate), given continuously without interruption, has been found to have a good effect on menopausal symptoms, at the same time as the endometrium is maintained or brought to an atrophic state. This method seems to be a new approach to oestrogenic therapy, and in spite of the inconvenience of rather frequent--though as a rule very slight--bleeding during the first months of treatment, it should be of value. After 3-4 mth of treatment bleeding practically never occurs and the endometrium almost invariably becomes completely atrophic. It would seem that this might imply a lowered risk of development of endometrial cancer. A series of 265 patients treated in accordance with this principle for up to more and than 4 yr is presented.
D000328:Adult; D000368:Aged; D001706:Biopsy; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology; D004958:Estradiol / Q000008:administration & dosage* / Q000627:therapeutic use; D004964:Estriol / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008593:Menopause / Q000187:drug effects*; D008875:Middle Aged; D009640:Norethindrone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077563:Norethindrone Acetate; D011897:Random Allocation
D004338:Drug Combinations; D004958:Estradiol; D000077563:Norethindrone Acetate; D004964:Estriol; D009640:Norethindrone