Captopril (SQ 14225) clearance during hemodialysis treatment.
The clearance of Captopril (SQ 14225) was examined in six hemodialysis patients, using a newly developed method for the determination of Captopril in blood. At 30 minutes after the start of hemodialysis, the clearance of Captopril was 80 +/- 14.2 ml/min, whereas that of creatinine was 123.4 +/- 8.8 ml/min and that of BUN was 144.1 +/- 7.2 ml/min. The blood concentration of Captopril was found to be lower when taken in a postprandial state than in a fasting state.
D000328:Adult; D002216:Captopril / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007674:Kidney Diseases / Q000378:metabolism / Q000628:therapy; D008297:Male; D011392:Proline / Q000031:analogs & derivatives*; D006435:Renal Dialysis
D011392:Proline; D002216:Captopril