Effect of a glucosidase inhibitor on the metabolic response of diabetic rats to a high carbohydrate diet, consisting of starch and sucrose, or glucose.
The metabolic consequences of the addition of Bay-g-5421 to a diet whose caloric value included 67% carbohydrate, comprising wheat starch (diet A), equal quantities of wheat starch and sucrose (diet B) or glucose (diet C) were studied in lean diabetic and non-diabetic rats. BAY-g-5421 led to a significant (30%) reduction in daily food intake of diabetic and non-diabetic rats fed diets A and B, respectively. In diabetic rats fed diets A and B with Bay-g-5421, daily urinary glucose was diminished ten-fold, while the post-prandial plasma glucose excursions were almost halved. Serum cholesterol, but not triglyceride concentrations, were reduced after five days, by the addition of BAY-g-5421 to diets A or B in non-diabetic rats, and in diabetic rats when the animals fed diets A and B were combined. BAY-g-5421 did not significantly after the food intake, urinary glucose excretion, post-prandial plasma glucose excursions nor serum lipids in diabetic and non-diabetic rats fed diet C. These findings illustrate the therapeutic potential of BAY-g-5421 as an adjunct to the dietary management of diabetes mellitus.
D020909:Acarbose; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D005947:Glucose / Q000008:administration & dosage; D005959:Glucosidases / Q000037:antagonists & inhibitors*; D065089:Glycoside Hydrolase Inhibitors; D006029:Glycosuria / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D009844:Oligosaccharides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013213:Starch / Q000008:administration & dosage; D013395:Sucrose / Q000008:administration & dosage; D014312:Trisaccharides / Q000494:pharmacology*
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D065089:Glycoside Hydrolase Inhibitors; D008055:Lipids; D009844:Oligosaccharides; D014312:Trisaccharides; D013395:Sucrose; D013213:Starch; D005959:Glucosidases; D005947:Glucose; D020909:Acarbose