Glomerular basement membrane changes in aging nondiabetic and diabetic guinea pigs.
Glomerular hyperplasia and thickening of the glomerular basement membrane increase with age in humans and animals. This glomerulopathy can be enhanced by hyperglycemic conditions such as diabetes mellitus. When diabetic guinea pigs were examined by fluorescent microscopy, deposits of a substance similar to immunoglobulin G (IgG) were seen. Comparison with nondiabetic age-matched control animals suggest that glomerulopathy is related to aging, and can be further enhanced by hyperglycemia.
D000375:Aging; D000818:Animals; D001485:Basement Membrane / Q000473:pathology*; D003920:Diabetes Mellitus / Q000276:immunology / Q000473:pathology*; D003928:Diabetic Nephropathies / Q000276:immunology; D005455:Fluorescent Antibody Technique; D005919:Glomerular Filtration Rate; D006168:Guinea Pigs; D006965:Hyperplasia / Q000378:metabolism; D007074:Immunoglobulin G / Q000032:analysis
D007074:Immunoglobulin G