Enzyme immunoassay of disopyramide in serum.
Disopyramide, an antiarrhythmic drug, was quantitated in serum by a commercially supplied enzyme immunoassay procedure. Replicate analyses of serum controls resulted in a within-assay coefficient of variation of less than or equal to 5% and a between-assay coefficient of variation of less than or equal to 7%. Regression analysis of 105 serum samples analyzed by this technique (y) and by gas chromatography (x) gave the equation y = 0.99x + 0.04 (r = 0.97). Clinical evaluation of the results indicates the enzyme immunoassay technique to be highly specific and sensitive for disopyramide. The selectivity of the assay vs other drugs has been determined.
D002849:Chromatography, Gas; D003429:Cross Reactions; D004206:Disopyramide / Q000097:blood*; D006801:Humans; D007124:Immunoenzyme Techniques; D011725:Pyridines / Q000097:blood*; D012044:Regression Analysis
D011725:Pyridines; D004206:Disopyramide