Inhibition of stress induced hyperglucagonemia by administration of glucose in normal and alloxan-diabetic rat.
The increase in plasma pancreatic glucagon which is known to occur under several stress conditions was confirmed in fed and 18 h prefasted rats subjected to a low, "stress producing" dose of the Noble-collip drum procedure (400 revolutions per 400 s). A single dose of exogenous glucose ( 1 g kg-1) injected 3 min and 20 s before stress into the jugular vein of intact fasted or fed animals anesthetized with pentobarbital 930 mg kg-1) completely abolished their hyperglucagonemic response in stress. In alloxan-diabetic hyperglycemic rats the stress-hyperglucagonemia was exaggerated, but was also suppressible by exogenous glucose. It was concluded that: 1. the stress induced hyperglucagonemic response of both intact and alloxan-diabetic rats was completely suppressible by administration of i.v. bolus of exogenous glucose; 2. the site inhibiting effect of glucose might be located either at the level of A cell or at the level of "'glucoreceptors" in hypothalamus.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003345:Corticosterone / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D005934:Glucagon / Q000097:blood*; D005947:Glucose / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008297:Male; D051381:Rats; D013312:Stress, Physiological / Q000097:blood*
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon; D005947:Glucose; D003345:Corticosterone