Doctor's versus patient's judgement in the assessment of mixed anxiety/depressive illness. Implications for measurement of therapeutic response.
The relationship of doctors' assessments to their patients' self-assessments was examined in a double-blind comparison of Motipress and Anafranil in patients suffering from mixed anxiety/depressive states. Significant differences between doctors' ratings were revealed which were largely parallelled by their patients' self-ratings done independently, suggesting differences between subgroups of patients within the whole population. Appropriate statistical analyses eliminated these factors in the data and showed that they did not affect the conclusions of a conventional statistical analysis of the two treatment groups as a whole; there were no significant differences between the major improvements associated with each treatment.
D000328:Adult; D000368:Aged; D001007:Anxiety / Q000150:complications* / Q000175:diagnosis; D002986:Clinical Trials as Topic; D002997:Clomipramine / Q000627:therapeutic use*; D003863:Depression / Q000150:complications* / Q000175:diagnosis; D004338:Drug Combinations; D005260:Female; D005476:Fluphenazine / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009661:Nortriptyline / Q000008:administration & dosage*; D011569:Psychiatric Status Rating Scales; D011897:Random Allocation; D012647:Self-Assessment
D004338:Drug Combinations; D009661:Nortriptyline; D002997:Clomipramine; D005476:Fluphenazine