[Systemic and local humoral immunity study using the indirect immunofluorescence reaction in chronic inflammatory lung disease patients. II. Serological research results with Haemophilus influenzae autostrains and their comparison with the level of systemic antipneumococcal immunity].
The indirect immunofluorescence test with the use of H. influenzae autostrains, carried out in patients with chronic bronchitis at the acute stage of the disease, did not reveal any correlation between the presence of these bacteria in the bronchial contents and systemic immune response in 26-39% of the patients. During the acute stage of chronic bronchitis a tendency towards enhancement of immune response to H. influenzae autostrains was observed. As indicated by the repeated test, this tendency was manifested by the prevalence of high antibody titers, the increase of the mean geometrical titer (p less than 0.05) reaching the dilution 1:1135 +/- 216 and the fold increase of the initial antibody level in 18.5 +/- 5.2% of the patients. 50 patients with chronic bronchitis were found to both pneumococci and H. influenzae in their bronchial contents; as indicated by the results of the indirect immunofluorescence test with the use of autostrains of these bacteria, in 18 patients (36 +/- 6.7%) equal antibody titers (+/- 1 dilution) were detected, while more than a half of serum samples (56 +/- 7%) showed the 4-fold an greater increase of th antipneumococcal antibody level, and only 4 samples proved to have the same prevalence of activity against H. influenzae.
D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D001991:Bronchitis / Q000276:immunology*; D002908:Chronic Disease; D005455:Fluorescent Antibody Technique; D006192:Haemophilus Infections / Q000276:immunology*; D006193:Haemophilus influenzae / Q000276:immunology*; D006801:Humans; D011008:Pneumococcal Infections / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology*
D000907:Antibodies, Bacterial
Izuchenie pri pomoshchi reaktsii nepriamoĭ immunofliuorestsentisii sistemnogo i mestnogo gumoral'nogo immuniteta u bol'nykh khronicheskimi vospalitel'nymi zabolevaniiami legkikh. Soobshchenie II. Rezul'taty serologicheskikh issledovaniĭ s autoshtammami Haemophilus influenzae i ikh sopostavlenie s urovnem antipnevmokokkovogo sistemnogo immuniteta.