99mTc-DTPA and 131I-hippuran findings in liver transplant recipients treated with cyclosporin A.
The effects of cyclosporin A (CyA), an immunosuppressive agent that is potentially nephrotoxic, on the kidneys of 9 liver transplant recipients were studied with serial 99mTc-DTPA and 131I-hippuran scans. In addition, renal function was determined by measuring serum creatinine levels during the second postoperative week in the 9 unselected CyA-treated patients and, retrospectively, in a control group of 29 liver transplant recipients who had not been treated with CyA and who were selected because they had survived for at least 3 months postoperatively. The early postoperative creatinine level was significantly greater in the CyA group. Eight of the 9 CyA patients showed imaging abnormalities in all preoperative and postoperative studies. Five of the 8 patients showed a pattern similar to that of acute tubular necrosis (relatively preserved perfusion) in at least one study. Lowering the dosage of CyA permitted the continuation of therapy, and all 9 patients are alive after 8 to 14 months.
D001663:Bilirubin / Q000097:blood; D003404:Creatinine / Q000097:blood; D003524:Cyclosporins / Q000009:adverse effects*; D006801:Humans; D007465:Iodohippuric Acid; D007668:Kidney / Q000000981:diagnostic imaging* / Q000187:drug effects; D016031:Liver Transplantation; D004369:Pentetic Acid; D011184:Postoperative Period; D011877:Radionuclide Imaging; D013667:Technetium; D016284:Technetium Tc 99m Pentetate
D003524:Cyclosporins; D007465:Iodohippuric Acid; D013667:Technetium; D004369:Pentetic Acid; D003404:Creatinine; D001663:Bilirubin; D016284:Technetium Tc 99m Pentetate