Pathogenesis of post-irradiation infections. I. Yersinia enterocolitica administered to normal and irradiated rats.
Infections after irradiation can be due to a great variety of microorganisms many of which are normally non-pathogenic or conditionally pathogenic for the host. The strain of Y. enterocolitica used was not pathogenic to a variety of unirradiated rats nor to athymic or B lymphocyte deprived, macrophage depleted rats, nor to normal rats irradiated by 5.7 Gy 24 hours before. However similarly irradiated rats receiving Y. enterocolitica 5 to 10 days later showed a substantial mortality. It is concluded that the radiosensitive mechanism for protection against Y. enterocolitica is not humoral nor cellular immunity as mediated by T and B lymphocytes or macrophages.
D000818:Animals; D002588:Cesium Radioisotopes; D005260:Female; D007109:Immunity / Q000528:radiation effects*; D008297:Male; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000276:immunology*; D011836:Radiation Tolerance; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014916:Whole-Body Irradiation; D015007:Yersinia / Q000472:pathogenicity; D015009:Yersinia Infections / Q000209:etiology* / Q000276:immunology
D002588:Cesium Radioisotopes