Origin of synovial type A cells during inflammation. An experimental approach.
Antigen-induced hypersensitivity arthritis in guinea pigs leads to histopathological changes in the synovial membrane similar to those seen in rheumatoid arthritis. Until recently, the characteristic lining-cell hyperplasia was believed to be mainly due to proliferation of synoviocytes. The validity of this hitherto predominating concept might be refused by our experimental cell-kinetic data, which demonstrate a pronounced participation of cells of the bone marrow-derived mononuclear phagocyte system in inner multilayer formation of the inflamed synovium. This view of the response of the synovium as a bone marrow-dependent reaction is strongly supported by whole-body irradiation experiments, which indicated that hyperplasia of the lining cell of the synovium is absent in animals with an induced cell depletion of the bone marrow.
D000818:Animals; D001168:Arthritis / Q000473:pathology; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D002244:Carbon / Q000378:metabolism; D002452:Cell Count; D002454:Cell Differentiation; D002465:Cell Movement / Q000528:radiation effects; D005260:Female; D006168:Guinea Pigs; D007074:Immunoglobulin G / Q000378:metabolism; D007249:Inflammation / Q000473:pathology*; D008264:Macrophages / Q000378:metabolism; D009000:Monocytes / Q000378:metabolism; D010586:Phagocytes / Q000378:metabolism; D013583:Synovial Membrane / Q000378:metabolism / Q000473:pathology* / Q000528:radiation effects; D013936:Thymidine / Q000378:metabolism; D014916:Whole-Body Irradiation
D007074:Immunoglobulin G; D002244:Carbon; D013936:Thymidine