title: [Current status of the problem of the treatment and prevention of hereditary diseases].
abstract: The author demonstrates the development of S. N. Davidenkov's concepts concerning the problem of treating and preventing hereditary diseases in modern genetics. The results of research work carried out by the author and her colleagues are presented. A new direction in the treatment of hereditary diseases, that is, targeted delivery of microincapsulated macromolecules (enzymes) to the cells, as an alternative to enzymotherapy, is described, and the results attained in this field are presented. Prospects of the new direction are demonstrated. Problems of prophylaxis and, particularly, prenatal diagnosis of hereditary diseases are described.
mesh_terms: D001161:Arteriosclerosis / Q000235:genetics; D004789:Enzyme Activation; D004798:Enzymes / Q000008:administration & dosage; D004926:Escherichia coli / Q000201:enzymology; D005526:Food, Formulated; D005817:Genetic Counseling; D030342:Genetic Diseases, Inborn / Q000517:prevention & control / Q000628:therapy*; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage; D011296:Prenatal Diagnosis / Q000379:methods
chemical_list: D004798:Enzymes; D008081:Liposomes
vernacular_title: Sovremennoe sostoianie problemy lecheniia i profilaktiki nasledstvennykh bolezneĭ.