In vivo changes in complement induced with peptidoglycan-polysaccharide polymers from streptococcal cell walls.
In rats injected with an arthropathogenic dose of streptococcal cell wall fragments, serum hemolytic activity decreased over the first 24 h and was then elevated from days 2 through 6 after injection. Hemolytic activity was again elevated at days 16 and 40. Levels of activity of alternative complement pathway, C3, and factor D were also altered.
D000818:Animals; D003167:Complement Activation; D003176:Complement C3 / Q000032:analysis; D011416:Complement Factor D / Q000378:metabolism; D003170:Complement Pathway, Alternative; D005260:Female; D010457:Peptidoglycan / Q000494:pharmacology*; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D051381:Rats; D013297:Streptococcus pyogenes / Q000032:analysis*; D013997:Time Factors
D003176:Complement C3; D010457:Peptidoglycan; D011135:Polysaccharides, Bacterial; D011416:Complement Factor D