Effect of captopril on blood pressure and bradykinin vasodepressor responses after nephrectomy and suppression of prostaglandin synthesis in anaesthetized rats.
1. Captopril markedly potentiated the vasodepressor responses to bradykinin. Neither the magnitude nor duration of the blood pressure fall were altered by bilateral nephrectomy or treatment with indomethacin which suppressed urinary excretion of the prostacyclin metabolite 6-Keto- PGF1 alpha. 2. It is concluded that in the anaesthetized rat augmentation of the bradykinin depressor responses by captopril occurs independently of endogenous prostaglandin synthesis.
D000768:Anesthesia, General; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001920:Bradykinin / Q000494:pharmacology*; D002216:Captopril / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009392:Nephrectomy; D011392:Proline / Q000031:analogs & derivatives*; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood
D011453:Prostaglandins; D011392:Proline; D002216:Captopril; D012083:Renin; D001920:Bradykinin; D007213:Indomethacin