A comparative trial of oral chloroquine and oral co-trimoxazole in vivax malaria in children.
Responses of parasitemia and fever in vivax malaria to standard doses of chloroquine and different dosage schedules of co-trimoxazole were compared in 165 children. Though both the drugs were effective, chloroquine was significantly faster in clearing parasitemia than all the dosage schedules of co-trimoxazole. No statistically significant difference was observed in rapidity of defervescence between chloroquine and the two high daily dosage regimens of co-trimoxazole. Gastrointestinal intolerance was persistently higher with chloroquine. Asymptomatic sulphonamide crystalluria was seen in a large number of cases receiving the two high daily dosage schedules of co-trimoxazole.
D000284:Administration, Oral; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004338:Drug Combinations / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008288:Malaria / Q000188:drug therapy*; D010966:Plasmodium vivax; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D014295:Trimethoprim / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D002738:Chloroquine; D014295:Trimethoprim; D013420:Sulfamethoxazole