Cytomorphology and lysosomal enzyme activity of the haemopoietic and reticuloendothelial system of the SJL/J mouse.
The cytomorphology and lysosomal enzyme activity of the haemopoietic and reticuloendothelial system (RES) of SJL/J mice, which develop a spontaneous reticulum cell neoplasm type B (RCN-B), were studied. The cytological findings during development of the disease were a predominance of medium-sized lymphocytes and an increase in the number of hyperbasophilic cells and plasma cells in the RES. These pathological findings were compared to the changes due to ageing in control groups of healthy C3H/eB mice. Acid phosphatase activity increased in the RES, whereas that of beta-D-glucuronidase remained unchanged during development of the disease. These findings indicate that the RCN-B of the SJL/J mice bear a certain resemblance to Hodgkin disease in man.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D005260:Female; D005966:Glucuronidase / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000201:enzymology / Q000473:pathology*; D007970:Leukopenia / Q000097:blood / Q000150:complications; D008198:Lymph Nodes / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000097:blood* / Q000150:complications / Q000201:enzymology; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D012157:Mononuclear Phagocyte System / Q000201:enzymology / Q000473:pathology*; D013154:Spleen / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology
D000135:Acid Phosphatase; D005966:Glucuronidase