Inhibition of polymorphonuclear leukocyte migration by sera of patients with rheumatoid arthritis.
The migration of peripheral polymorphonclear leukocytes (PMN) of patients with rheumatoid arthritis (RA) and normal controls was studied using autologous sera and homologous rheumatoid positive and negative sera. A significant inhibition of cells from RA patients was observed using autologous or homologous rheumatoid sera in contrast to patients' PMN exposed to control sera in which no significant migration inhibition was detected. Negative results were observed when rheumatoid sera were used with PMN from normal controls. No correlation was found between the degree of PMN migration inhibition and the titer of rheumatoid factor. The results of these studies indicate that mononuclear cells in rheumatoid patients have varying degrees of sensitization to certain factor(s) in rheumatoid sera.
D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001769:Blood; D002464:Cell Migration Inhibition; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000378:metabolism; D009504:Neutrophils / Q000276:immunology*; D012217:Rheumatoid Factor / Q000096:biosynthesis
D008263:Macrophage Migration-Inhibitory Factors; D012217:Rheumatoid Factor