Hepatic glucose production oscillates in synchrony with the islet secretory cycle in fasting rhesus monkeys.
Oscillations in the concentration of plasma glucose were found to reflect large fluctuations in hepatic glucose production. The fluctuations in glucose production were synchronous with fluctuations in the concentration of plasma insulin and glucagon. This synchrony suggests that hepatic pathways are entrained to the islet cycle with a minimal time delay.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D005215:Fasting; D005934:Glucagon / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008099:Liver / Q000378:metabolism*; D008253:Macaca mulatta; D010507:Periodicity
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon; D005947:Glucose