Excretion studies of nitrofurantoin and nitrofurantoin with deglycyrrhizinated liquorice.
Nitrofurantoin and nitrofurantoin with liquorice were given to healthy volunteers and patients suffering from urinary tract infections. The excretion rates of the drug, colony counts and side effects were studied in patients and excretion rates in the volunteers. The excretion rates of the drug were significantly higher in patients receiving the drug with liquorice and also side effects were minimal. There was no significant difference in the excretion rates of the drug with addition of liquorice in healthy volunteers.
D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006035:Glycyrrhiza; D006801:Humans; D009582:Nitrofurantoin / Q000008:administration & dosage / Q000009:adverse effects / Q000652:urine*; D010946:Plants, Medicinal; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology / Q000652:urine*
D009582:Nitrofurantoin