title: [Contraceptive activity and mechanism of action of combinations of 6-methyl-substituted D'6-pentaranes and mestranol].
abstract: It has been shown in experiments on rats, mice and rabbits that 6 alpha-methyl-16 alpha, 17 alpha-cyclohexano-pregna-4-en-3, 20-dion and 6-methyl-16 alpha, 17 alpha-cyclohexano-pregna-4,6-dien-3,20-dion belonging to the series of D'6-pentaranes exhibit high contraceptive activity when combined with mestranol. The contraceptive activity of D'6-pentaranes combined with mestranol arises primarily from their inhibitory effect on luteinizing function of the hypophysis.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D004394:Dydrogesterone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004971:Estrus; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000032:analysis; D007275:Injections, Intravenous; D007986:Luteinizing Hormone / Q000032:analysis; D008473:Median Eminence / Q000032:analysis; D008656:Mestranol / Q000008:administration & dosage*; D051379:Mice; D010060:Ovulation / Q000187:drug effects; D010902:Pituitary Gland / Q000032:analysis; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D011817:Rabbits; D051381:Rats
chemical_list: D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; C030177:6-methyl-16 alpha,17 alpha-cyclohexylpregna-4,6-dien-3,20-dione; C030176:6 alpha-methyl-16 alpha,17 alpha-cyclohexylpregn-4-en-3,20-dione; D007986:Luteinizing Hormone; D004394:Dydrogesterone; D008656:Mestranol
vernacular_title: Kontratseptivnaia aktivnost' i mekhanizm deĭstviia kompozitsiĭ 6-metilzameshchennykh D'6-pentaranov i mestranola.