Low levels of antibodies to surface antigens of group B streptococci in commercial IgG preparations.
53 different batches of commercial IgG were tested for antibodies to group B streptococci (GBS) types Ia, Ib, II and III. The levels of antibodies varied widely. Comparison of the anti-GBS antibody levels in these preparations with those found in normal blood donor sera showed that the commercial IgG contained approximately 2.6 times less type-specific antibodies. We conclude that the commercial IgG now available is not optimal for passive immunization against GBS infections in neonates.
D000942:Antigens, Bacterial / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D006801:Humans; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000276:immunology*; D007231:Infant, Newborn; D013292:Streptococcus agalactiae / Q000276:immunology*
D000942:Antigens, Bacterial; D000954:Antigens, Surface; D007074:Immunoglobulin G