title: The inhibitory effect of vinylfurans on the glycolysis in tumor and yeast cells.
abstract: Most of the eighteen vinylfurane derivatives studied fully inhibit the glycolysis of both Ehrlich ascites carcinoma (EAC) cells and respiratory deficient yeast Saccharomyces cerevisiae at concentrations lower than 0.5 mmol/l. The inhibition of glycolysis is a consequence of some thiol enzymes inactivation. This concerns namely hexokinase (EC 2.7.1.1), glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) and especially 6-phosphofructokinase (EC 2.7.1.11). Interference of vinylfurans with energy metabolism resulted in the depression of biosynthetic processes followed (14C-precursors incorporation into proteins and nucleic acids) and finally in the loss of EAC cell transplantability.
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects; D005663:Furans / Q000494:pharmacology*; D006019:Glycolysis / Q000187:drug effects*; D051379:Mice; D012441:Saccharomyces cerevisiae / Q000378:metabolism*
chemical_list: D005663:Furans; C027684:2-vinylfuran