Treatment of nephrotic edema with bumetanide.
In a crossover study bumetanide, 2 to 6 mg/d, was compared with furosemide, 40 to 160 mg/d, in the treatment of 10 patients with the nephrotic syndrome and massive edema. The two drugs, which both act on the loop of Henle, were found to be equally effective. Patients with renal insufficiency responded poorly to both drugs.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001835:Body Weight / Q000187:drug effects; D002034:Bumetanide / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004232:Diuretics / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy*; D005260:Female; D005665:Furosemide / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000188:drug therapy*
D004232:Diuretics; D002034:Bumetanide; D005665:Furosemide