title: Clinical and histologic indications for extensive pancreatic resection in nesidioblastosis.
abstract: Nine children with nesidioblastosis underwent pancreatic resection at St. Louis Children's Hospital. Four of these underwent 99 percent of near-total resection. Only one child required permanent insulin therapy postoperatively. Pathologic examination of the resected pancreases revealed a diffuse disturbance of the pancreatic architecture. Prolonged hypoglycemia can have devastating neurologic sequelae. Based on clinical experience and the pathologic demonstration of a diffuse process in the affected pancreas, it is advocated that near-total (99 percent) pancreatectomy is the primary procedure of choice for this disease.
mesh_terms: D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology; D007223:Infant; D007231:Infant, Newborn; D007515:Islets of Langerhans / Q000473:pathology; D008297:Male; D010180:Pancreatectomy / Q000379:methods*; D010182:Pancreatic Diseases / Q000150:complications / Q000473:pathology / Q000601:surgery*