Pre-interventional prognostic value of renal endocrine, hemodynamic and arteriographic parameters in hypertensive patients with uni- and bilateral renal artery stenosis: a ten years' experience.
In order to improve pre-interventional prognosis of blood pressure normalization, in patients normalization, in patients with angiographically proven uni- (n = 75) and bilateral (n = 38) renal artery stenosis, (RAS) evaluation of renal venous and peripheral renin activity including stimulative procedures and Saralasin-infusion-test was carried out. In addition selective renal arteriographic, hemodynamic and pharmacodynamic (133 xe-washout) investigations were performed. The data were correlated with operative results concerning response of blood pressure to surgical treatment in 54 patients with uni- and 30 patients with bilateral RAS. Our results suggest that a postoperative normalization of blood pressure can only be expected if pre-interventional selective arteriograms reveal a normal vascular tree accompanied with normal cortical flow rates of both kidneys in uni- and bilateral RAS. Selective renin determinations, stimulative procedures of the renin-angiotensin system and application of angiotensin antagonists are only of value for selection of patients.
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006978:Hypertension, Renovascular / Q000150:complications; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011183:Postoperative Complications; D011300:Preoperative Care; D011379:Prognosis; D011859:Radiography; D012078:Renal Artery Obstruction / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery; D012079:Renal Circulation; D012083:Renin / Q000378:metabolism*
D012083:Renin