[Drug resistance to malaria. Apropos of 17 cases in 2 years].
17 cases of resistant P. falciparum malaria are reported. They were observed in different populations: on one hand 9 Cambodian children refugees in France, on the other hand 8 French adults consulting after travels in South America or in South-East Asia. Different resistance levels to amino-4-quinolines and to a combination of sulfadoxine and pyrimethamine were found: they were more often from the RI type but sometimes from the RIII type also. 6 patients were treated with Mefloquine. Its activity was constant and rapid.
D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D004352:Drug Resistance, Microbial; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D015767:Mefloquine; D010880:Piperidines / Q000627:therapeutic use; D010963:Plasmodium falciparum / Q000187:drug effects; D011804:Quinolines / Q000627:therapeutic use; D013413:Sulfadoxine / Q000627:therapeutic use
D000962:Antimalarials; D010880:Piperidines; D011804:Quinolines; D013413:Sulfadoxine; D015767:Mefloquine
Chimio-résistance du paludisme. A propos de 17 cas en deux ans.