title: [Effect of etmozin on the atrioventricular conduction system function of the heart in paroxysmal subventricular tachycardia].
abstract: With the aid of intracavitary electrophysiological investigation in hospital the influence of ethmosin, an antiarrhythmic agent, on the function of atrio-ventricular conducting system was studied in 52 patients with paroxysmal supraventricular tachicardias. It was established that the drug depresses significantly the electrophysiological values of Kent's bundle, the His-Purkinje system and atrioventricular node (mainly in the retrograde conduction): and also prolongs considerably the time of the intra-atrial conduction. Ethmosin exerts practically no influence on the refractory periods of the atria and on the function of the atrioventricular node for the anterograde conduction. These data suggest that ethmosin may be an effective antiarrhythmic agent in treating patients with certain forms of paroxysmal disorders of the cardiac rhythm in whom the atrioventricular node and Kent bundle are involved in the re-entry.
mesh_terms: D000293:Adolescent; D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D006328:Cardiac Catheterization; D004341:Drug Evaluation; D004562:Electrocardiography; D006329:Heart Conduction System / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D016293:Moricizine; D010640:Phenothiazines / Q000627:therapeutic use*; D013614:Tachycardia, Paroxysmal / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; D016293:Moricizine
vernacular_title: Vliianie étmozina na funktsiiu predserdno-zheludochkovoĭ provodiashcheĭ sistemy serdtsa u bol'nykh s paroksizmal'nymi nadzheludochkovymi takhikardiiami.