Primary dapsone-resistant leprosy in Cebu, Philippines.
A survey of the prevalence of primary dapsone-resistant leprosy in Cebu, Philippines, has yielded an estimate of 3.6 per 100. Fifty-three of 55 patients proved to have M. leprae fully susceptible to dapsone. The organisms of two patients multiplied in mice administered the minimal effective dose of dapsone; and those of one of these patients also multiplied in mice administered dapsone in a 10-fold larger dose.
D000818:Animals; D003622:Dapsone / Q000494:pharmacology / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D006801:Humans; D007918:Leprosy / Q000188:drug therapy* / Q000382:microbiology; D051379:Mice; D008808:Mice, Inbred CBA; D009166:Mycobacterium leprae / Q000187:drug effects; D010679:Philippines
D003622:Dapsone