The Salmonella mutagenicity assay on fenticonazole, a new antifungal imidazole derivative.
alpha-(2,4-Dichlorophenyl)-beta,N-imidazolylethyl 4-phenylthiobenzyl ether nitrate (fenticonazole, Rec 15/1476), a new potent antibacterial and antifungal imidazole derivative, was tested for mutagenicity in the Salmonella reversion assay developed by Ames et al. Fenticonazole was found to be negative for strains TA 1535, TA 1537, TA 1538, TA 98, TA 100 with and without microsomal activation.
D000818:Animals; D001431:Bacteriological Techniques; D007093:Imidazoles / Q000633:toxicity*; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics*; D013045:Species Specificity
D007093:Imidazoles; D009153:Mutagens; C033486:fenticonazole