Rapid inhibition of lipogenesis in vivo in lactating rat mammary gland by medium- or long-chain triacylglycerols and partial reversal by insulin.
An intragastric load of medium- or long-chain triacylglycerols inhibited lipogenesis in lactating rat mammary gland in vivo by 82 or 89% respectively. This inhibition was reversed partially by insulin administration. Long-chain triacylglycerols inhibited hepatic lipogenesis in vivo but medium-chain triacylglycerols increased it 2-fold. Glucose utilization in vitro by mammary gland acini from triacylglycerol-fed rat was normal.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D003864:Depression, Chemical; D005260:Female; D005947:Glucose / Q000378:metabolism; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D007774:Lactation; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D014280:Triglycerides / Q000494:pharmacology*
D007328:Insulin; D008055:Lipids; D014280:Triglycerides; D005947:Glucose