title: A multicentre open trial indapamide in general practice.
abstract: In a multicentre open study, 99 patients were treated with indapamide (2.5 mg daily) by 19 general practitioners. Fourteen patients failed to complete the study and in most cases this was unrelated to active therapy. Fifty patients had not previously received antihypertensive therapy, 25 patients had been on previous antihypertensive therapy with either unsatisfactory blood pressure control of side effects and the remaining 10 patients had indapamide added to their existing therapy. Of the 85 patients who did complete, the mean reduction in blood pressure at the end of 4 months treatment was 26 mmHg systolic and 17 mmHg diastolic. In those patients who were studied for at least 12 months treatment, blood pressure control was maintained in the majority. No severe side effects were reported.
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004232:Diuretics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007190:Indapamide / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; D007190:Indapamide