[Granulopoietic progenitor cells and the hemopoietic potential of a graft: a study in the dog model (author's transl)].
Four beagles received a standardized dose of 33000-44000 CFU-C per kg b.w. isolated from the peripheral blood of DLA-identical donors. Three had permanent reconstitution of hemopoiesis while in one regeneration was abortive. This indicates that the CFU-C assay is able to predict for the hemopoietic potential of a graft. However, considerable differences in the regeneration pattern of CFU-C in the bone marrow demonstrated that the number of repopulating stem cells was variable.
D000818:Animals; D016026:Bone Marrow Transplantation; D004285:Dogs; D006098:Granulocytes; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells; D012038:Regeneration; D014184:Transplantation, Homologous
Granulozytär determinierte Vorläuferzellen (CFU-C) und hämopoetisches Potential: Eine Studie im Hundemodell.