Malignant hypertension in a child with hemolytic-uremic syndrome treated with captopril.
A 5-year-old boy is presented suffering from malignant hypertension due to hemolytic-uremic syndrome. Captopril, an oral angiotensin-1-converting enzyme inhibitor, was able to curb the natural course of the malignant hypertension. Haemodialysis could be discontinued after 2 months. The glomerular filtration rate recovered to 63 ml/min/1.73 m2 11 months after the acute phase.
D002216:Captopril / Q000627:therapeutic use*; D002675:Child, Preschool; D006463:Hemolytic-Uremic Syndrome / Q000150:complications*; D006801:Humans; D006974:Hypertension, Malignant / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D011392:Proline / Q000031:analogs & derivatives*
D011392:Proline; D002216:Captopril