Effect of phentolamine on the metabolic response to gynaecological surgery.
The effect of the infusion of phentolamine 0.5 mg min-1 on the metabolic response to gynaecological surgery was investigated. In comparison with the control group of patients, phentolamine was associated with a significant increase in plasma insulin concentration after 30 and 60 min of surgery. The glycaemic response to surgery was decreased by alpha-adrenergic blockade, but this was only significant after 120 min of surgery. The hypotension produced by the administration of phentolamine was well tolerated.
D000328:Adult; D000409:Alanine / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D005187:Fallopian Tubes / Q000601:surgery*; D005260:Female; D005990:Glycerol / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D006400:Hematocrit; D006801:Humans; D007328:Insulin / Q000097:blood; D007773:Lactates / Q000097:blood; D010646:Phentolamine / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D007773:Lactates; D000409:Alanine; D005990:Glycerol; D010646:Phentolamine