[New findings on the importance of the histocompatibility Y antigen for sex differentiation and its role in the origin of developmental disorders of the reproductive organs].
In the differentiation of the male reproductive organs the histocompatibility antigen Y plays an important role, which is formed under physiological conditions under the influence of a gene of the Y-chromosome in the most cell types of male mammals and occurs in the cell membranes. The H-Y is delivered by Sertoli's cells and furthers the development of the testicles. These cells moreover deliver testosterone-binding protein and an inhibiting factor for the development of Müller's ducts. For the effectiveness of testosterone the equipment of the in their function testosterone-depending cell types with androgen-receptor protein is necessary, the formation of which is conditioned by a gene lying on the X-chromosome. For the maturation and preservation of the viability of the oocytes two functioning X-chromosomes are necessary. Several disturbances of the development of the reproductive organs as well as the trans-sexuality are demonstrated taking into consideration recent realizations.
D012734:Disorders of Sex Development / Q000235:genetics*; D005260:Female; D006680:HLA Antigens / Q000502:physiology*; D006801:Humans; D007621:Karyotyping; D008297:Male; D012708:Sertoli Cells / Q000502:physiology; D012730:Sex Chromosomes; D012733:Sex Differentiation; D013737:Testis / Q000196:embryology; D014189:Transsexualism / Q000235:genetics
D006680:HLA Antigens
Neuere Erkenntnisse über die Bedeutung des Histokompatibilitätsantigens Y für die sexuelle Differenzierung sowie über dessen Bedeutung bei der Entstehung von Entwicklungsstörungen der Fortpflanzungsorgane.