Suppression of the hypothalamic-pituitary-adrenal axis after a single intramuscular injection of methylprednisolone acetate.
Fourteen patients with hay fever were treated with one intramuscular injection of methylprednisolone acetate, which gave satisfactory symptomatic relief for three weeks. Their hypothalamic-pituitary-adrenal function was moderately but significantly suppressed for three weeks but became normal again after four weeks.
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007003:Hypoglycemia / Q000139:chemically induced; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D007273:Injections, Intramuscular; D007328:Insulin / Q000009:adverse effects; D008297:Male; D008775:Methylprednisolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077555:Methylprednisolone Acetate; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000187:drug effects*; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*
D007328:Insulin; D000077555:Methylprednisolone Acetate; D006854:Hydrocortisone; D008775:Methylprednisolone