Studies on the responses of plasma renin activity and aldosterone and cortisol levels to dopaminergic and opiate stimuli in man.
Evidence for a role of dopamine and endogenous opioids in the control of the secretion of renin and adrenal steroids was sought in man. The effects of L-dopa, L-dopa plus carbidopa, dopamine, domperidone and naloxone were studied on the renin and aldosterone responses to head-up tilt. L-dopa diminished the rise in renin following tilt and this effect of L-dopa was abolished by carbidopa. Aldosterone was not significantly affected by any of the compounds. Cortisol secretion was stimulated by carbidopa plus L-dopa more than L-dopa alone, and was also increased by both dopamine and naloxone. The significance of these findings is discussed.
D000328:Adult; D000450:Aldosterone / Q000097:blood*; D002230:Carbidopa / Q000494:pharmacology; D004294:Domperidone / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D011187:Posture; D012083:Renin / Q000097:blood*
D009270:Naloxone; D007980:Levodopa; D000450:Aldosterone; D004294:Domperidone; D012083:Renin; D002230:Carbidopa; D004298:Dopamine; D006854:Hydrocortisone