Immuno-cyto-chemical staining of mid-gut carcinoid tumours with sequence-specific gastrin antisera.
Twenty typical mid-gut carcinoid tumours were examined for the presence of gastrin immuno-reactivity to antisera specific to the C-terminal pentapeptide or to the mid-portion of gastrin-17. Pentagastrin immuno-reactivity was found in seven cases, and in one of these reactivity to antiserum against the mid-portion of gastrin-17 was also observed. The results are in accordance with the previous observation that argyrophil tumour cells are present in mid-gut carcinoid tumours and may explain why peptic ulcer disease is sometimes seen in association with the carcinoid syndrome.
D000328:Adult; D000368:Aged; D000818:Animals; D002276:Carcinoid Tumor / Q000473:pathology*; D004759:Enterochromaffin Cells / Q000032:analysis; D005260:Female; D005755:Gastrins / Q000032:analysis*; D006801:Humans; D007078:Ileal Neoplasms / Q000473:pathology*; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D011817:Rabbits
D005755:Gastrins