[Comparison of the level of epithelial cell proliferation in the liver, islands of Langerhans and pancreatic acini of mice from the age and individual viewpoints].
The index of labelled nuclei (ILN) was determined in the mouse liver and pancreas epithelium within 24 hrs following five injections of 3H-thymidine. Five age groups were studied with the mean weight 15, 19, 20.4, 24.3, and 28.2 g. The ILN was equal in hepatocytes, respectively, to 5.2, 0.6, 0.03, 0.13 and 0.02%, in pancreatic islet cells to 4.6, 4.1, 1.7, 1.5, and 0.7%, and in acinar cells to 0.4, 1.1, 0.07, 0.30, and 0.10%. Marked individual ILN variations were observed. In hepatocytes the highest ILN in each age group correlated positively with maximal absolute liver weight and, in four groups, with its maximal relative weight. The maximal ILN indices did not coincide for the three cell types. A suggestion is put forward on relationship between ILN fluctuations and unequal character or organ growth and asynchrony of growth of different organs.
D000375:Aging; D000818:Animals; D002455:Cell Division; D002467:Cell Nucleus / Q000648:ultrastructure; D004847:Epithelial Cells; D007515:Islets of Langerhans / Q000166:cytology*; D008099:Liver / Q000166:cytology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010179:Pancreas / Q000166:cytology*
Sopostavlenie urovnia proliferatsii épitelial'nykh kletok pecheni, ostrovkov Langergansa i atsinusov podzheludochnoĭ zhelezy mysheĭ v vozrastnom i individual'nom aspektakh.