[Antibiotic prophylaxis in surgery (author's transl)].
Post-operative infections are of course due to bacterial contamination, but also to local conditions favourable to bacterial growth, and to lowering of host defences. Antibiotic prophylaxis is indicated in "clean-contamined" surgery, in surgery on immunodepressed patient and in bone prosthesis. The risk is mainly ecological. Antibiotics are useless when administered after the first post-operative day. The results of well-conducted controlled studies demonstrating, for instance, the value of metronidazole in surgery of the large bowel and appendix are reported.
D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use; D011292:Premedication; D011300:Preoperative Care
D000900:Anti-Bacterial Agents; D008795:Metronidazole
Antibiothérapie prophylactique en chirurgie.