About the possibilities of registration of drug influence by means of radiocardiographic function analysis.
Changes in cardiac dynamics were analyzed by means of radiocardiographic function analysis under an infusion of epinephrine using the method of RAB. Typical changes in heart rate, stroke volume and blood pressure were observed after the application of epinephrine. Compared to examinations under physical exercise in case of healthy control subjects there was no typical decrease of enddiastolic volume dependent on the heart rate. Ejection time and ejection velocity was placed within the variation compared to values of a control group under physical exercise but there was a steeper increase of the curve under the effect of epinephrine. Under the influence of Solcoseryl no significant change could be observed in this series of tests compared to the basic values. The effect of epinephrine was changed by Solcoseryl in the way of an essentially smaller rise in heart rate and of a definite prolongation  in diastolic time. A change in ejection time under the influence of epinephrine after the application of Solcoseryl could not be found. This allows the conclusion, that under the influence of Solcoseryl and after the administration of epinephrine better conditions for the metabolic restitution of heart muscle are given and consequently a direct effect of Solcoseryl on the heart muscle can be assumed.
D000183:Actihaemyl / Q000494:pharmacology*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D005082:Physical Exertion; D011865:Radioisotope Dilution Technique; D013318:Stroke Volume / Q000187:drug effects; D014020:Tissue Extracts / Q000494:pharmacology*
D014020:Tissue Extracts; D000183:Actihaemyl; D004837:Epinephrine