title: Rbe of densely ionizing radiation for wild-type and radiosensitive mutants of yeast.
abstract: Survival curves were obtained for haploid and diploid yeasts, Saccharomyces cerevisiae, of wild-type strains and radiosensitive mutants exposed to gamma-rays and alpha-particles. A correlation between the values of the relative biological effectiveness (RBE) of high-LET radiation and cell-repair capacity was found. The difference in radiosensitivities of the wild-type diploid strain and homozygous rad mutants incapable of recovery was significantly higher after low-LET radiation than after high-LET radiation. Possible reasons for the observed radiation responses to low- and high-LET exposure of yeast cells with various genotype are discussed.
mesh_terms: D000512:Alpha Particles; D004260:DNA Repair; D004171:Diploidy; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006238:Haploidy; D009154:Mutation / Q000528:radiation effects*; D011836:Radiation Tolerance; D012062:Relative Biological Effectiveness; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000528:radiation effects