title: Environmental factors affecting chemoreceptors: an overview.
abstract: Vertebrate olfactory and gustatory receptors are necessarily exposed to the fluid which contains their relevant chemosensory environment. In terrestrial mammals, the nasal airways serve as protective accessory tissues for the olfactory receptors, but tastes receptors in all vertebrates and olfactory receptors in fish are directly exposed to the liquids which bring chemosensory stimuli to them. The differentiated epithelial cells which form taste buds and the specialized neurons which are the vertebrate olfactory receptors are constantly replaced in normal adult animals, suggesting that chemosensory function per se is damaging to the receptors. Organic and sulfur-containing air pollutants may be among those which adversely affect olfactory receptors, but adequate data are not available. Surfactants and heavy metals can produce physiological and/or morphological damage in gustatory receptors. Some heavy metals are concentrated in saliva, a liquid which interacts closely with taste receptors. A failure to evaluate human chemosensory function in relation to potential chemosensory toxicants accounts for the present inability to specify the incidence of the problem.
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D002628:Chemoreceptor Cells / Q000502:physiology*; D004777:Environment; D004787:Environmental Pollution; D009422:Nervous System Diseases / Q000139:chemically induced; D012903:Smell / Q000502:physiology; D013649:Taste / Q000502:physiology; D014877:Water Pollution, Chemical