Studies on the behavior of H-Y incompatible skin grafts in rats.
Studies on the behavior of H-Y incompatible skin grafts in rats indicate that 1) there is considerable variation in the ability of females of different strains to reject male skin isografts; 2) small, male trunk skin isografts are more likely to be rejected than similarly sized ear or tail skin grafts; 3) other factors besides the MHC plan an important role in determining the ability of females to reject male skin isografts; 4) the ability of adult male skin grafts to induce unresponsiveness to H-Y depends upon their size (large grafts are more effective than small) and the genotype of the host; 5) even in those strains in which females usually accept small, male trunk skin isografts, such grafts are acutely rejected by sensitized females; and 6) the total amount of H-Y incompatible trunk skin the host is exposed to, rather than the size of each graft, determines their fate.
D000818:Animals; D004423:Ear; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006182:H-Y Antigen / Q000235:genetics / Q000276:immunology*; D006648:Histocompatibility; D007108:Immune Tolerance; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D011920:Rats, Inbred WF; D016038:Skin Transplantation; D013623:Tail
D006182:H-Y Antigen