Antigenic requirement for induced rejection of long-surviving murine heart transplants.
Primarily vascularized B10.BR mouse cardiac allografts survive long-term in untreated B6AF1 recipients. We found that sudden complete rejection of the grafts was produced by sequential "triple treatment" with BCG, cyclophosphamide, and a small number of donor-strain lymphocytes. Neither the graft itself, nor donor-strain platelets or frozen-thawed lymphocytes were an effective substitute for the intact donor-strain lymphocytes. Thus the long-surviving graft presents target antigens but lacks the antigenic characteristics required to stimulate a rejection response that are expressed on lymphocytes.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D001500:BCG Vaccine / Q000494:pharmacology; D001792:Blood Platelets / Q000276:immunology; D003520:Cyclophosphamide / Q000494:pharmacology; D004306:Dose-Response Relationship, Immunologic; D006084:Graft Rejection; D006085:Graft Survival; D016027:Heart Transplantation; D008214:Lymphocytes / Q000276:immunology* / Q000528:radiation effects; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013997:Time Factors
D000941:Antigens; D001500:BCG Vaccine; D003520:Cyclophosphamide