Effect of protein-free parathyroid extract (PF-PTE) and gamma-L-glutamyl-taurine (glutaurine) on X-ray induced hyperglycaemia in the rat.
The protein-free parathyroid extract (PF-PTE) and gamma-L-glutamyl-taurine (glutaurine) produced mild hypoglycaemia in rats. Treatment with PF-PTE or glutaurine prevented the development of hyperglycaemia induced by X-ray whole body irradiation with 154.8 or 219.3 or 258.0 mC/kg doses. The plasma IRI values did not change following treatment. It is supposed that glutaurine acts by its antagonistic effect on glucocorticoids but its regenerating effect on the intestinal mucosa cannot be excluded either.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003864:Depression, Chemical; D005973:Glutamine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D006943:Hyperglycemia / Q000097:blood / Q000209:etiology / Q000628:therapy*; D007328:Insulin / Q000097:blood / Q000276:immunology; D008297:Male; D010280:Parathyroid Glands; D010281:Parathyroid Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013654:Taurine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D014020:Tissue Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D014965:X-Rays / Q000009:adverse effects
D001786:Blood Glucose; D007328:Insulin; D010281:Parathyroid Hormone; D014020:Tissue Extracts; D005973:Glutamine; D013654:Taurine; C020903:glutaurine