In vivo inhibition of respiratory syncytial virus by ribavirin.
Ribavirin reduced the amount of respiratory syncytial virus in nasal turbinates and lung tissues of experimentally infected cotton rats by over 90%. An effect was seen when the drug was given either intraperitoneally or by aerosol; however, the antiviral effect was achieved at much lower doses when delivered by the aerosol route. No animal deaths due to the drug were seen.
D000336:Aerosols; D000818:Animals; D003411:Arvicolinae; D007274:Injections, Intraperitoneal; D008168:Lung / Q000382:microbiology; D012136:Respiratory Syncytial Viruses / Q000187:drug effects; D010253:Respirovirus Infections / Q000188:drug therapy*; D012254:Ribavirin / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D012263:Ribonucleosides / Q000627:therapeutic use*
D000336:Aerosols; D012263:Ribonucleosides; D012254:Ribavirin