Interim results of EORTC protocol 08742: comparison, after irradiation of locally advanced squamous cell bronchial carcinoma, of abstention, immunotherapy, combination chemotherapy, or chemoimmunotherapy.
After irradiation of locally unresectable epidermoid bronchial carcinoma, 1 year of chemotherapy is significantly superior in delaying both local recurrences and distant metastases and prolonging the disease-free interval. However, BCG immunotherapy alone seems to be superior in terms of survival to no therapy, chemotherapy, and immunochemotherapy. This could be due to a better tolerance to secondary treatments given at time of recurrence.
D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000628:therapy*; D002986:Clinical Trials as Topic; D005500:Follow-Up Studies; D006801:Humans; D007167:Immunotherapy; D008175:Lung Neoplasms / Q000532:radiotherapy / Q000628:therapy*; D009163:Mycobacterium bovis / Q000276:immunology