title: Repression of cytosine deaminase by pyrimidines in Salmonella typhimurium.
abstract: The synthesis of cytosine deaminase in Salmonella typhimurium is repressed by pyrimidines. This repression is mediated by both a uridine and a cytidine compound, indicating a distinct difference in the regulation of synthesis of cytosine deaminase from the regulation of the de novo pyrimidine pathway enzymes. A salvage role for the enzyme in pyrimidine metabolism is postulated.
mesh_terms: D003470:Culture Media; D003562:Cytidine / Q000494:pharmacology; D003596:Cytosine / Q000494:pharmacology; D043525:Cytosine Deaminase; D004794:Enzyme Repression; D009700:Nucleoside Deaminases / Q000096:biosynthesis*; D011743:Pyrimidines / Q000378:metabolism / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000201:enzymology*; D014498:Uracil / Q000494:pharmacology
chemical_list: D003470:Culture Media; D011743:Pyrimidines; D014498:Uracil; D003562:Cytidine; D003596:Cytosine; D009700:Nucleoside Deaminases; D043525:Cytosine Deaminase