[Posttraumatic osteomyelitis. Mode of infection, significance of metal implants].
Guniea-pigs of the Duncan-Hartley strain were used in a model of posttraumatic osteomyelitis. One femur had been fractured with or without consequent metal implantation and infected subsequently with 10(7) or 10(5) staphylococcus aureus or E. coli. 85% of the animals infected with staph. aureus and 56% infected with E. coli developed osteomyelitis. Healing of infection occurred in 3 cases only and always in the absence of metal implants. All bone infection persisting for more than 3 months were also detectable after 12-18 months. The assessment of opsonising factors revealed a long lasting deficiency in guinea-pigs with metal implants.
D000818:Animals; D001858:Bone Nails / Q000009:adverse effects*; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000472:pathogenicity; D005264:Femoral Fractures / Q000601:surgery; D005593:Fracture Fixation, Internal / Q000009:adverse effects*; D006168:Guinea Pigs; D009895:Opsonin Proteins / Q000032:analysis; D010019:Osteomyelitis / Q000209:etiology / Q000276:immunology; D010587:Phagocytosis; D013211:Staphylococcus aureus / Q000472:pathogenicity; D014774:Virulence
D009895:Opsonin Proteins
Posttraumatische Osteomyelitis. Infektionsmodus, Bedeutung der Metallimplantation.