Quinine alone versus quinine plus a pyrimethamine-sulfadoxine combination in the treatment of Plasmodium faliciparum cerebral malaria.
Fifty-two patients with severe chloroquine resistant Plasmodium falciparum malaria were treated in a randomized double blind study with either quinine and a single dose of pyrimethamine-sulfadoxine (Fansidar) or quinine alone. Although no statistically significant differences were observed, the 25 patients who received both drugs responded faster and had a more favorable outcome (no deaths) when compared to the 27 who received quinine alone (2 deaths).
D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D010963:Plasmodium falciparum; D011739:Pyrimethamine / Q000008:administration & dosage* / Q000627:therapeutic use; D011803:Quinine / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation; D013413:Sulfadoxine / Q000008:administration & dosage* / Q000627:therapeutic use; D013424:Sulfanilamides / Q000008:administration & dosage*
D004338:Drug Combinations; D013424:Sulfanilamides; D013413:Sulfadoxine; D011803:Quinine; D011739:Pyrimethamine