title: [Diabetes and alcohol].
abstract: In a survey the effect of alcohol on carbohydrate tolerance and insulin is discussed. In an individually different degree alcohol, by hepatic, pancreatic and peripheral effects, contributes to manifestation of diabetes and negatively affects the secretion of insulin after manifestation of diabetes. In persons with intact metabolism the influence of alcohol partly results in an increase of stimulated insulin secretion. But from data found in literature must be assumed that a reduction of insulin secretion predominates in the long run. Moreover, diabetics run the risk of contracting hypoglycemia especially in cases where alcohol addicts are treated with hypoglycemizing drugs. Alcohol inhibits gluconeogenesis and glyconeogenesis and, at hepatic level, yet influences other enzyme systems. In addition we find in diabetes chronic liver lesions in a great number, quite independent of alcohol effects. However, dependent on a specific individual situation, alcohol may lead to severe metabolic disorders. In view of a general increase of alcohol addiction these aspects should result in a more critical dealing with alcohol problem in the general information of patients.
mesh_terms: D003920:Diabetes Mellitus / Q000378:metabolism*; D000431:Ethanol / Q000378:metabolism* / Q000494:pharmacology; D005943:Gluconeogenesis / Q000187:drug effects; D005951:Glucose Tolerance Test; D006003:Glycogen / Q000096:biosynthesis; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion
chemical_list: D007328:Insulin; D000431:Ethanol; D006003:Glycogen
vernacular_title: Diabetes und Alkohol.