Comparison of the mutagenicity and teratogenicity of cyclophosphamide and its active metabolites, 4-hydroxycyclophosphamide, phosphoramide mustard, and acrolein.
D000171:Acrolein / Q000494:pharmacology*; D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D003520:Cyclophosphamide / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D010752:Phosphoramide Mustards / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship; D013723:Teratogens
D000447:Aldehydes; D009153:Mutagens; D010752:Phosphoramide Mustards; D013723:Teratogens; C030090:phosphoramide mustard; C012358:4-hydroxycyclophosphamide; D000171:Acrolein; D003520:Cyclophosphamide