Frontiers of the biological sciences.
The history of the molecular revolution in biology is described, emphasizing its dependence on the emergence of bacterial genetics, the fusion of genetics and biochemistry, and the development of greatly improved techniques for studying macromolecules. Central concepts have included molecular information transfer, both by nucleic acids and by allosteric proteins; the spontaneous conversion of one-dimensional information into three-dimensional structures; and the extraordinary unity in the molecular mechanisms underlying the rich diversity of biology. The merging of molecular and morphological studies, to yield the very broad field of cell biology, is described more briefly, as are also some present frontiers in several areas of biology that present challenges at other levels of organization.
D000486:Allergy and Immunology / Q000639:trends; D000494:Allosteric Regulation; D005075:Biological Evolution; D001695:Biology / Q000266:history*; D004247:DNA / Q000235:genetics; D004274:DNA, Recombinant; D004626:Embryology / Q000639:trends; D005786:Gene Expression Regulation; D005818:Genetic Engineering; D005823:Genetics / Q000639:trends*; D049673:History, 20th Century; D008566:Membranes / Q000502:physiology; D008967:Molecular Biology / Q000639:trends; D009369:Neoplasms / Q000209:etiology; D009462:Neurology / Q000639:trends; D009690:Nucleic Acid Conformation; D014176:Protein Biosynthesis; D012270:Ribosomes / Q000502:physiology; D014158:Transcription, Genetic
D004274:DNA, Recombinant; D004247:DNA