[Homeostasis of glucose and gastric resection. The influence of the food passage through the duodenum (author's transl)].
In 45 patients there was performed an oral glucose tolerance test after different types of gastric resection (Billroth I, Billroth II, total gastrectomy with a reconstitution with preservation of the food passage through the duodenum, total gastrectomy with exclusion of the duodenum). Additionally some patients with the same type of resection but with different types of stomach disease were investigated. The following results were achieved: 1. An increasingly reduction of the gastric remnant - 60% resection (B I), 75% resection (B II), total gastrectomy - leads after an oral glucose load to increasingly more rapid rise of blood glucose as well as to increasingly higher peak values of blood glucose concentration. 2. In patients with preserved food passage through the duodenum the oral glucose tolerance is significantly better and the secretory capacity of the beta-cells is significantly higher. 3. In spite of the same type of gastric resection patients with different types of stomach disease have as well as different patterns of oral glucose tolerance curve. Patients with Billroth II - gastric resection because of duodenal ulcer have significant more frequently a late postprandial hypoglycemia (without preceding hyperglycemia) than the patients with Billroth II because of ulcer/neoplasma ventriculi.
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D004386:Duodenum / Q000378:metabolism*; D004947:Esophagus / Q000601:surgery; D005260:Female; D005743:Gastrectomy / Q000379:methods*; D005951:Glucose Tolerance Test; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007408:Intestinal Absorption; D007583:Jejunum / Q000637:transplantation; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000601:surgery; D013276:Stomach Ulcer / Q000601:surgery
D001786:Blood Glucose; D007328:Insulin
Glukosehomöostase und Magenresektion. Die Bedeutung der Nahrungspassage durch das Duodenum.