The cancer research campaign (King's/Cambridge trial for early breast cancer: clinico-pathological aspects.
Analysis of pathological data in the 10th year of follow-up of a multicentre trial of the management of operable breast cancer has confirmed the correlation of prognosis with tumour grade, tumour size and lymph-node status. For each factor examined there was no difference in survival between the 2 treatment groups ("watch policy" and radiotherapy) but patients in the WP group whose tumours were of Grade II or III or greater than 2 cm, or with lymph-node metastases, had a greater chance of local recurrence. Cellular reaction had no relationship with prognosis, except in patients with Grade III tumours. The clinical relevance and application of these results are discussed.
D000368:Aged; D001943:Breast Neoplasms / Q000276:immunology / Q000473:pathology* / Q000532:radiotherapy; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008938:Mitosis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis