Demonstration of urokinase-related fibrinolytic activity in human plasma.
Various preparations of anti-urokinase antibodies were found to quench a part of the plasma fibrinolytic activity. This part was also inhibited by a specific, urokinase inhibitor isolated from placenta. These observations indicate that plasma contains a urokinase-related immuno-reactivity. This activity was found to belong to the factor XII-independent proactivator system.
D000906:Antibodies; D001798:Blood Proteins; D010450:Endopeptidases / Q000097:blood*; D005342:Fibrinolysis; D006801:Humans; D014568:Urokinase-Type Plasminogen Activator / Q000037:antagonists & inhibitors / Q000097:blood* / Q000276:immunology
D000906:Antibodies; D001798:Blood Proteins; C031220:urokinase inhibitor; D010450:Endopeptidases; D014568:Urokinase-Type Plasminogen Activator