[The hydrocortisone test (400 mg hydrocortisone test) for the study of the "recirculating" lymphocyte population. Tests of patients with lymphoproliferative diseases and solid neoplasms].
The hydrocortisone test has been performed on 20 patients with lymphoproliferative disease (MH, LNH, CLL, MM, BMG) and 12 patients with solid neoplasm to study the "recirculating" lymphocytic population (mainly T lymphocytes with "helper" function). Therefore, as proposed by Fauci and Dale, we counted the basal venous blood lymphocytes in the morning after fasting and then 4 h after the administration of hydrocortisone 400 mg. While the test did not appear to be statistically modified in patients with solid neoplasms as compared to normal controls, it appears particularly compromised in lymphoproliferative diseases, but with different values in each disease. The results are discussed on the basis of lymphocytic kinetic data.
D000328:Adult; D000368:Aged; D001769:Blood; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000494:pharmacology; D007958:Leukocyte Count; D008232:Lymphoproliferative Disorders / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014680:Veins
C007133:hydrocortisone hemisuccinate; D006854:Hydrocortisone
Il test all'idrocortisone (test OHC 400 mg) per lo studio della popolazione linfocitaria "ricircolante". Indagine in pazienti con malattie linfoproliferative e con neoplasie solide.