title: Animal models of tinnitus.
abstract: There are few physiological data available on the origin and nature of tinnitus. It is not even known whether tinnitus associated with cochlear pathology is a manifestation of increased or decreased activity in the cochlear nerve. In previous investigations of cochlear pathology, the spontaneous neural activity has generally been found to be depressed. In the present experiments, an animal model has been established by the administration of sodium salicylate in doses producing blood concentrations that evoke tinnitus in humans. Under these conditions, changes occur in cochlear nerve-fibre thresholds and tuning, similar to those obtained in other types of cochlear pathology. However, under salicylate, the distribution of spontaneous discharge shifts significantly to higher rates than normal. These changes are accompanied in some, but not all, fibres by changes in the temporal patterns of discharge suggestive of excitation. In the second animal model studied, a normal guinea-pig that had a naturally occurring continuous tonal emission, analogous to that recently recorded in human "physiological" tinnitus, was investigated in detail. The emitted signal was recorded in the ear-canal acoustic pressure and in the round-window potential. Several lines of evidence point to the signal as being cochlear in origin, including: its resistance to muscular paralysis and section of the stapedius muscle; the effects of changes in middle-ear pressure; its reversible elimination by hypoxia; and its suppression by tones of higher frequency.
mesh_terms: D000161:Acoustic Stimulation; D000200:Action Potentials / Q000187:drug effects; D000368:Aged; D000818:Animals; D002415:Cats; D003056:Cochlear Nerve / Q000187:drug effects / Q000503:physiopathology; D004195:Disease Models, Animal; D004432:Ear, Middle / Q000293:injuries / Q000503:physiopathology; D006168:Guinea Pigs; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology; D010100:Oxygen; D011312:Pressure; D012459:Salicylates / Q000494:pharmacology; D013997:Time Factors; D014012:Tinnitus / Q000503:physiopathology
chemical_list: D012459:Salicylates; D008012:Lidocaine; D010100:Oxygen