title: Dubious effect of dimethylsulphoxide (DMSO) therapy on amyloid deposits and amyloidosis.
abstract: Data from the literature on DMSO therapy for amyloidosis in laboratory animals and man are reviewed and found to be inconclusive. In hamsters with casein-induced amyloidosis, as well as in dogs with spontaneous amyloidosis, therapeutic experiments with DMSO were performed. In these investigations no effect of DMSO on amyloid and amyloidosis was found.
mesh_terms: D000682:Amyloid / Q000378:metabolism; D000686:Amyloidosis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000662:veterinary; D000818:Animals; D002364:Caseins / Q000009:adverse effects; D006224:Cricetinae; D004121:Dimethyl Sulfoxide / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000188:drug therapy / Q000378:metabolism; D004285:Dogs; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism
chemical_list: D000682:Amyloid; D002364:Caseins; D004121:Dimethyl Sulfoxide