title: Effect of artificial pancreas treatment on peripheral nerve function in diabetes.
abstract: To determine whether the complete correction of hyperglycemia of diabetes can rapidly improve abnormal peripheral nerve function, eight hyperglycemic insulin-requiring diabetics underwent 3 days of glucose control with an artificial endocrine pancreas, the BIOSTATOR Glucose Controller. Comparison of neurologic assessment before and after BIOSTATOR treatment showed improvement only in ulnar sensory conduction velocity (+ 3.2 +/- 1.4 meters per second, p less than 0.032) and no significant changes in 24 other nerve conduction measurements, computer-assisted examination, and scored neurologic assessment. Any significant beneficial effect on nerve function resulting from correction of hyperglycemia probably requires more than 3 days to be manifested.
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002986:Clinical Trials as Topic; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007332:Insulin Infusion Systems; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D010525:Peripheral Nerves / Q000503:physiopathology*; D012684:Sensory Thresholds; D014110:Touch
chemical_list: D001786:Blood Glucose