Analysis of the LH surges induced by mating and LH-RH in the vole, Microtus agrestis.
Female voles mated with a male and experiencing a single ejaculatory series exhibited a rapid and marked elevation of plasma LH levels. The profile of the LH surge had a broad peak 20-40 min after mating. Pentobarbitone sodium administered immediately after mating did not affect the magnitude of the surge. The LH response to exogenous LH-RH ws not affected by the state of receptivity of the female or by gonadectomy. There was no evidence of any priming effect of 25 ng LH-RH on the pituitary response to a second injection of LH-RH 20 or 60 min later. These results are consistent with the primary cause of the LH surge in the reflexly ovulating vole being a rapid secretion of LH-RH.
D000758:Anesthesia; D000818:Animals; D003411:Arvicolinae / Q000502:physiology*; D002369:Castration; D003307:Copulation; D004305:Dose-Response Relationship, Drug; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone