Cervical dilatation in late first trimester termination by prostaglandin, hylase and isogel.
Pre-operative dilatation of the cervix was attempted in 223 cases prior to vacuum aspiration in patients seeking late first trimester termination beyond ten weeks. 15 Me PGF2a was used in the form of vaginal suppositories, intramuscular and intracervical injections. Dilatation of cervix of 10 mm or more was achieved within 4 hours in 86% cases with intra-cervical injections. Gastro-intestinal disturbances caused by intra-muscular injections could be avoided by intra-cervical injections, as the amount of prostaglandin required was only 100 ugm, but the success rate was significantly lower. The success with multiple dose suppositories was 80%. There was no significant difference in the success with 1.5 mgm or 1.0 mgm dosage, but the side effects were significantly higher with 1.5 mgm suppositories. Intra-cervical Hylase did not dilate the cervix but successfully softened it within 5 minutes to make metallic dilatation simple. The hygroscopic Isogel tents achieved dilatation of 10 mm or more in 73% of the patients in 12 hours. The tents as well as intra-cervical prostaglandin injection had the disadvantage of requiring an additional theatre procedure prior to suction curettage.
D000028:Abortion, Induced; D002260:Carboprost / Q000008:administration & dosage*; D002584:Cervix Uteri / Q000187:drug effects*; D004106:Dilatation / Q000379:methods; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D010447:Peptide Hydrolases / Q000008:administration & dosage*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage*; D011620:Psyllium / Q000008:administration & dosage*; D013488:Suppositories; D014619:Vacuum Curettage
D011461:Prostaglandins F, Synthetic; D013488:Suppositories; D002260:Carboprost; D011620:Psyllium; D010447:Peptide Hydrolases; C021430:hylase