title: Are pyrimidine dimers non-instructive lesions?
abstract: Published data from yeast and E. coli show that base substitution induced by UV in pyrimidine-pyrimidine sequences is not random, and suggest that fidelity of DNA replication is not entirely lost during transdimer synthesis. These observations question whether cyclobutane pyrimidine dimers are truly non-instructive lesions.
mesh_terms: D004260:DNA Repair; D004269:DNA, Bacterial / Q000528:radiation effects; D004271:DNA, Fungal / Q000528:radiation effects; D004926:Escherichia coli / Q000235:genetics; D009154:Mutation; D011740:Pyrimidine Dimers / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics; D014466:Ultraviolet Rays
chemical_list: D004269:DNA, Bacterial; D004271:DNA, Fungal; D011740:Pyrimidine Dimers