[Immunostimulating properties of an extract isolated from Aloe vahombe. 2. Protection in mice by fraction F1 against infections by Listeria monocytogenes, Yersinia pestis, Candida albicans and Plasmodium berghei].
A partially purified extract of leaves of Aloe vahombe, a plant endemic in the south of Madagascar, administered intravenously to mice, protects them against infection of bacteria (Listeria monocytogenes, Yersinia pestis), parasites (Plasmodium berghei) and fungus (Candida albicans). The protective fraction must be administered two days before inoculation of the pathogenic agent. These results significantly confirm those we obtained in earlier study on mice infection by Klebsiella pneumoniae. Currently we are testing the protective action of the purified extract on the experimental development of sarcomas, and we are in the process of analysing the mode of action of this non specific immunostimulant.
D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000627:therapeutic use; D000504:Aloe; D000818:Animals; D002177:Candidiasis / Q000517:prevention & control*; D007275:Injections, Intravenous; D008088:Listeriosis / Q000517:prevention & control*; D008288:Malaria / Q000517:prevention & control*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010946:Plants, Medicinal; D010962:Plasmodium berghei / Q000187:drug effects; D015009:Yersinia Infections / Q000517:prevention & control*
D000276:Adjuvants, Immunologic; D010936:Plant Extracts
Etude des proprietés immunostimulantes d'un extrait isolé à partir d'Aloe vahombe.