Immunofluorescent staining of rat brain glial cells with multiple sclerosis serum.
Antibodies directed against glial cells may be involved in autoimmunity in multiple sclerosis (MS). Using a tissue culture system, the presence of glial cell antibodies in MS-patient serum was detected through immunofluorescent technique. Thirty one of 73 MS-sera were strongly positive for anti-glial cells, 13 were equivocal and 29 were negative. The antibody staining was either cytoplasmic or associated with cell surface membrane, and involved IgG type of antibody.
D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology*; D009115:Muridae; D009457:Neuroglia / Q000276:immunology*; D009836:Oligodendroglia / Q000276:immunology*
D001323:Autoantibodies; D007106:Immune Sera; D007074:Immunoglobulin G