title: [Preliminary results on the effects of pretreatment with thymic extract on experimental endotoxin hepatitis in the mouse].
abstract: The Authors wish to examine the protective effects which a period of pre-treatment with thymostimulin, would have on endotoxin hepatitis, induced in thymectomized and non-thymectomized animals. The test showed that the histological picture and the degree of endotoxinemia, measured with the Lymulus test, benefited from treatment with a thymic extract. This therapy was effect (and was statistically significant) in obtaining an immunorestoring effect (in the thymectomized mouse) and in inducing an immunostimulating effect (in the normal mouse).
mesh_terms: D000818:Animals; D004731:Endotoxins / Q000097:blood*; D004926:Escherichia coli; D005260:Female; D006520:Hepatitis, Animal / Q000188:drug therapy*; D008099:Liver / Q000473:pathology; D051379:Mice; D013934:Thymectomy; D013949:Thymus Extracts / Q000627:therapeutic use*
chemical_list: D004731:Endotoxins; D013949:Thymus Extracts; C031407:thymostimulin
vernacular_title: Risultati preliminari sugli effetti di un pretrattamento con estratto timico nell'epatite sperimentale da endotossina nel topo.