Demonstration of glucagon in the stomach of human fetuses.
Electron microscopy using antiglucagon or antiglicentin antisera and the protein A-gold (pAg) technique revealed a population of immunoreactive cells in the gastric mucosa of human fetuses. The secretory granules of these cells showed the same ultrastructural characteristics and the same labeling pattern as pancreatic alpha-granules. These data demonstrate that the stomach of human fetuses contains cells with secretory granules indistinguishable by morphologic and immunocytochemical criteria from the pancreatic A-cells.
D003594:Cytoplasmic Granules / Q000648:ultrastructure; D005260:Female; D005753:Gastric Mucosa / Q000196:embryology / Q000378:metabolism* / Q000648:ultrastructure; D005934:Glucagon / Q000378:metabolism*; D006651:Histocytochemistry; D006801:Humans; D007118:Immunoassay; D007515:Islets of Langerhans / Q000648:ultrastructure; D011247:Pregnancy
D005934:Glucagon