Lethal effect of CAMP-factor and UBERIS-factor--a new finding about diffusible exosubstances of streptococcus agalactiae and Streptococcus uberis.
CAMP-factor, the exosubstance of Streptococcus agalactiae, and UBERIS-factor, the exosubstance of Streptococcus uberis, exerted lethal effect when administered parenterally to rabbits and white mice. A single intravenous dosis of 1,500 activity units per 1 kg body weight resulted in rapid death of the rabbits. To kill mice, the intravenous or intraperitoneal dosis had to be 45 times higher in relation to the body mass. After formaldehyde treatment, both streptococcal exosubstances were deprived of their lethal effect as well as of their synergistic hemolytic activity with the staphylococcal beta-toxin.
D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology; D001688:Biological Products / Q000633:toxicity*; D004357:Drug Synergism; D006460:Hemolysin Proteins; D006461:Hemolysis / Q000187:drug effects; D051379:Mice; D011817:Rabbits; D013108:Sphingomyelin Phosphodiesterase; D013291:Streptococcus / Q000032:analysis*; D013292:Streptococcus agalactiae / Q000032:analysis*
D001427:Bacterial Toxins; D001688:Biological Products; D006460:Hemolysin Proteins; D013108:Sphingomyelin Phosphodiesterase; C029878:hlb protein, Staphylococcus aureus