Renal transplantation in systemic lupus erythematosus.
3 patients with chronic renal failure due to lupus nephritis received kidney allografts from cadaver donors. Serological activity was present in 2 patients at the time of transplantation, and continued unabated despite intensive immunosuppressive therapy. Their allograft failed at 5 and 7 months after transplantation. Anti-DNA antibody in the allograft was found in 1 patient. The 3rd patient, with no serological activity at the time of transplantation, remained serologically negative, and her allograft functioned for 18 months. The persistence of serological activity in 1 patient, and the recovery of anti-DNA antibody from her allograft provide proof for the recurrence of lupus nephritis in the allograft.
D000328:Adult; D001323:Autoantibodies / Q000276:immunology; D004247:DNA / Q000276:immunology; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000276:immunology / Q000601:surgery*; D007678:Kidney Glomerulus / Q000276:immunology; D016030:Kidney Transplantation; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D009393:Nephritis / Q000150:complications* / Q000276:immunology; D012008:Recurrence
D001323:Autoantibodies; D004247:DNA