Absence of an antihypertensive effect of 12 hour infusions of an angiotensin antagonist in chronic renal hypertensive rabbits.
The effect of a continuous 12-hour infusion of a saline solution of the angiotensin II antagonist, [Sar1, Ile8] angiotensin II, on mean arterial pressure was studied in 11 conscious New Zealand white rabbits with hypertension induced by renal artery stenosis and contralateral nephrectomy, and in 11 normotensive control rabbits. Also, the effect on mean arterial pressure of infusing saline alone for 12 hours was examined in 4 hypertensive rabbits and in 8 normotensive controls. There were no significant differences in the changes in mean arterial pressure among the 4 groups of rabbits at any hourly period during these infusions. These studies were unable to provide evidence that angiotensin II is involved in maintaining the elevated arterial pressure in this hypertensive animal model.
D015059:1-Sarcosine-8-Isoleucine Angiotensin II / Q000494:pharmacology; D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D001806:Blood Urea Nitrogen; D004195:Disease Models, Animal; D006973:Hypertension / Q000097:blood; D006977:Hypertension, Renal / Q000503:physiopathology*; D008297:Male; D011817:Rabbits; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects; D012965:Sodium Chloride / Q000494:pharmacology
D000804:Angiotensin II; D012965:Sodium Chloride; D015059:1-Sarcosine-8-Isoleucine Angiotensin II; D012083:Renin