Biochemical properties of the renin binding substance of rat kidney.
Renin extracted from isolated renin granules of the rat is a low molecular weight form (40,000 daltons). The renin binding substance which is capable of binding with the low molecular weight renin to form a high molecular weight renin (60,000 daltons) under sulfhydryl oxidation was found to be contained in the crude extract of rat renal cortex. This substance is presumably a protein with molecular weight of over 47,000 daltons by gel filtration. The most striking event was that rat renin binding substance was bound with dog renin and vice versa.
D000818:Animals; D002238:Carbohydrate Epimerases; D002352:Carrier Proteins / Q000302:isolation & purification / Q000378:metabolism*; D002846:Chromatography, Affinity; D004285:Dogs; D007668:Kidney / Q000378:metabolism*; D007672:Kidney Cortex / Q000378:metabolism; D007679:Kidney Medulla / Q000378:metabolism; D008970:Molecular Weight; D051381:Rats; D012083:Renin / Q000302:isolation & purification / Q000378:metabolism*
D002352:Carrier Proteins; D012083:Renin; D002238:Carbohydrate Epimerases; C024519:N-acyl-D-glucosamine 2-epimerase; C498258:Renbp protein, rat