Ethosuximide in tears, saliva, and cerebrospinal fluid.
Ethosuximide (ESM) was determined by the EMIT technique in tears, saliva, cerebrospinal fluid (CSF), and plasma of epileptic subjects. CSF/plasma, saliva/plasma and saliva/CSF ratios were in good agreement with gas-liquid chromatography (GLC). The tears/plasma ratio was not significantly different from the saliva/plasma ratio, although the standard deviation was higher in the latter. These data indicate that ESM can be determined in a quantitatively similar manner in both saliva and tears by EMIT.
D000328:Adult; D002648:Child; D004827:Epilepsy / Q000378:metabolism*; D005013:Ethosuximide / Q000134:cerebrospinal fluid / Q000378:metabolism*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D012463:Saliva / Q000378:metabolism*; D013666:Tears / Q000378:metabolism*
D005013:Ethosuximide