Dubious effect of dimethylsulphoxide (DMSO) therapy on amyloid deposits and amyloidosis.
Data from the literature on DMSO therapy for amyloidosis in laboratory animals and man are reviewed and found to be inconclusive. In hamsters with casein-induced amyloidosis, as well as in dogs with spontaneous amyloidosis, therapeutic experiments with DMSO were performed. In these investigations no effect of DMSO on amyloid and amyloidosis was found.
D000682:Amyloid / Q000378:metabolism; D000686:Amyloidosis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000662:veterinary; D000818:Animals; D002364:Caseins / Q000009:adverse effects; D006224:Cricetinae; D004121:Dimethyl Sulfoxide / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000188:drug therapy / Q000378:metabolism; D004285:Dogs; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism
D000682:Amyloid; D002364:Caseins; D004121:Dimethyl Sulfoxide