Effect of Saliment on parotid salivary gland secretion and on xerostomia caused by Sjögren's syndrome.
The stimulatory effect of a recently introduced saliva substitute (Saliment) on the parotid salivary secretion was experimentally investigated in 10 healthy individuals without signs or symptoms of xerostomia and in 11 patients with xerostomia due to Sjögren's syndrome. Further, in 15 patients with Sjögren's syndrome, the effect of Saliment on the sensation of xerostomia was examined in a double-blind clinical study with cross-over. The use of Saliment was followed by a significant stimulation in the parotid salivary secretion (P less than 0.01) and the subjection sensation of xerostomia was significantly reduced (P less than 0.01).
D000293:Adolescent; D000328:Adult; D000368:Aged; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D005990:Glycerol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives*; D008875:Middle Aged; D010306:Parotid Gland / Q000378:metabolism*; D012463:Saliva; D012636:Secretory Rate / Q000187:drug effects; D012859:Sjogren's Syndrome / Q000628:therapy*; D013012:Sorbitol / Q000494:pharmacology*; D013997:Time Factors; D014987:Xerostomia / Q000188:drug therapy*
D004338:Drug Combinations; C034179:saliment; D013012:Sorbitol; D008747:Methylcellulose; D002266:Carboxymethylcellulose Sodium; D005990:Glycerol