Syntheses of 9-acridine- and 2-phenanthridinemethanols as potential antimalarials.
alpha-(1-Piperidinylmethyl)-9-acridinemethanol (3), alpha-[(dibutylamino)ethyl]-9-acridanmethanol (4a), and alpha-[(dibutylamino)methyl]-2-phenanthridinemethanol (5) have been made and all are ineffective as antimalarials against Plasmodium berghei in mice. 9-Acridinyloxirane showed no significant mutagenicity for strains TA 98 or TA 100 of Salmonella typhimurium.
D000166:Acridines / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials; D004353:Drug Evaluation, Preclinical; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D010617:Phenanthridines / Q000138:chemical synthesis / Q000494:pharmacology*; D010962:Plasmodium berghei / Q000187:drug effects
D000166:Acridines; D000962:Antimalarials; D010617:Phenanthridines