Bactericidal and antineoplastic effect of combination of gentamicin and adriamycin.
Gentamicin and adriamycin were tested against eight strains of Proteus mirabilis: using the cellophane transfer technique, combinations of these antibiotics were screened for bactericidal activity. On mice bearing Ehrlich ascites carcinoma, the antitumoral effect of a combination of gentamicin and adriamycin was determined. Antagonism occurred with the combination in bactericidal activity and not in antitumoral activity.
D000818:Animals; D000903:Antibiotics, Antineoplastic; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D004317:Doxorubicin / Q000494:pharmacology*; D004338:Drug Combinations; D005260:Female; D005839:Gentamicins / Q000494:pharmacology*; D051379:Mice; D008826:Microbial Sensitivity Tests; D011513:Proteus mirabilis / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; D004338:Drug Combinations; D005839:Gentamicins; D004317:Doxorubicin