The effect of prostacyclin on some hemodynamic parameters in dogs.
The following hemodynamic parameters were determined in anesthetized mongrel dogs: heart rate, systolic blood pressure in the ascending aorta, left ventricular pressure at the peak dp/dt, left ventricular end-diastolic pressure, time intervals from Q in ECG to peak dp/dt, maximum rate of left ventricular pressure rise, femoral arterial flow and certain indices of left ventricular contractility. It was demonstrated that prostacyclin even in high doses has no significant effect on hemodynamic parameters in dogs.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007275:Injections, Intravenous; D009200:Myocardial Contraction / Q000187:drug effects; D011453:Prostaglandins / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D013997:Time Factors
D011453:Prostaglandins; D011464:Epoprostenol