Survey on substrate specificity with regard to ATP analogs of aminoacyl-tRNA synthetases from E. coli and from Baker's yeast. Correlation to synthetase families.
The substrate specificity of twenty aminoacyl-tRNA synthetases from E. coli and thirteen enzymes from baker's yeast with regard to eight ATP analogs is investigated for a comparison of the active-site topography. The enzymes are arranged in a scheme of possible "enzyme families" and compared to earlier schemes.
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives*; D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism*; D004926:Escherichia coli / Q000201:enzymology*; D007700:Kinetics; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D013045:Species Specificity; D013329:Structure-Activity Relationship
D000255:Adenosine Triphosphate; D000604:Amino Acyl-tRNA Synthetases