Failure of systemically administered corticosteroids to suppress UVB-induced delayed erythema.
The effects of systemic corticosteroids on ultraviolet-induced delayed erythema were observed in a double-blind controlled study. The backs of human volunteers were irradiated with ultraviolet B (UVB) sources, and subsequent response was observed while ingesting prednisone (80 mg by mouth for 3 days) of placebo. Prednisone given 24 hours before, immediately after, 24 hours or 48 hours after exposure did not increase the redness, edema, or tenderness of the exposed sites.
D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004890:Erythema / Q000188:drug therapy*; D006801:Humans; D011241:Prednisone / Q000627:therapeutic use*; D013471:Sunburn / Q000188:drug therapy; D013997:Time Factors; D014466:Ultraviolet Rays / Q000009:adverse effects*
D011241:Prednisone