title: Clinical trials of the efficacy and duration of antibacterial cover for elective resection in inflammatory bowel disease.
abstract: A prospective double-blind placebo controlled trial was performed to test the values of 24-h cover with metronidazole and gentamicin in 57 patients requiring elective resections for inflammatory bowel disease (phase 1). The short term antimicrobial cover was not associated with a reduction in the incidence of postoperative sepsis. A further group of 30 patients who received metronidazole and gentamicin cover for 5 days (phase 2) was therefore studied and the results were compared with phase 1. There was a significant reduction in the incidence of sepsis in the patients receiving 5-day postoperative antibiotic cover compared with the placebo group.
mesh_terms: D000328:Adult; D001424:Bacterial Infections / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D003093:Colitis, Ulcerative / Q000601:surgery*; D003424:Crohn Disease / Q000601:surgery*; D004311:Double-Blind Method; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D008875:Middle Aged; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D005839:Gentamicins; D008795:Metronidazole