Long-term, double-blind, between patients comparison of indoprofen and indomethacin in rheumatoid arthritis.
Forty-one patients suffering from classical or definite rheumatoid arthritis were randomly allocated to either indoprofen (800 mg/day) or indomethacin (100 mg/day) treatment in a double-blind, comparative long-term study (6 months). Both drugs reduced the symptoms of rheumatoid arthritis. A marked improvement was generally achieved within the first month and was maintained thereafter. Indoprofen was somewhat better tolerated than indomethacin.
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage*; D007216:Indoprofen / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010666:Phenylpropionates / Q000008:administration & dosage*; D011897:Random Allocation
D010666:Phenylpropionates; D007216:Indoprofen; D007213:Indomethacin