Comparison of the mechanism of action of cyclic 11,12-erythromycin A carbonate and erythromycin A.
Synthesis of polyphenylalanine and polylysine in the E. coli MRE 600 and Q 13 cell-free systems was inhibited by erythromycin A and cyclic 11, 12-erythromycin A carbonate to a similar or identical extent. Both compounds inhibited translation of phage f2 RNA in the E. coli Q13 cell-free system. Neither antibiotic affected binding of initiator tRNA or phage f2 RNA to E. coli ribosomes, and neither inhibited translation of BMV RNA in the wheat-germ cell-free system.
D002474:Cell-Free System; D003090:Coliphages / Q000378:metabolism*; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004926:Escherichia coli / Q000378:metabolism*; D007700:Kinetics; D010452:Peptide Biosynthesis; D010455:Peptides; D011107:Polylysine / Q000096:biosynthesis; D014176:Protein Biosynthesis / Q000187:drug effects*
D010455:Peptides; D011107:Polylysine; C012001:polyphenylalanine; C029784:erythromycin A cyclic 11,12-carbonate; D004917:Erythromycin