title: Segmental replacement of the femur in baboons with fiber metal implants and autologous bone grafts of different particle size.
abstract: A study was made of bone ingrowth into fiber metal composite prostheses used to replace large segments of the femur in baboons. Bone grafts of two different types were used to cover the segment: chips of bone with large particle size and ground bone with a smaller particle size. The prosthetic segment was bridged by bone at 3 and 6 months in all cases irrespective of the structure of the transplant. In animals sacrificed at 6 months bone ingrowth occurred, with a marked difference between specimens with the two different grafts. In the ground bone specimens ingrowth occurred over the total surface area, and bone penetrated deep into the composite. With the chip grafts ingrowth was more irregular occurring only in some areas and it was always superficial. The difference is believed to be due to the improved contact between the fiber metal surface and the transplant. The lesser bulk of the ground transplant is advantageous when the soft tissue cover of the bone is thin.
mesh_terms: D000497:Alloys; D000818:Animals; D016025:Bone Transplantation; D005260:Female; D005269:Femur / Q000254:growth & development / Q000601:surgery*; D010215:Papio; D010316:Particle Size; D019736:Prostheses and Implants; D013997:Time Factors; D014025:Titanium
chemical_list: D000497:Alloys; C031462:titanium alloy (TiAl6V4); D014025:Titanium