Antibody forming cells in long-term culture of rabbit bone marrow cells.
Bone marrow cells from 4 LPS-immunized rabbits were cultured in liquid media for 10 weeks and anti-LPS direct plaque-forming cells were enumerated periodically. Plaque-forming cells decreased for the first 2-4 weeks then increased without addition of LPS. This increase in the number of plaque-forming cells might be ascribed to the differentiation of committed precursors and/or the proliferation of plaque-forming cells.
D000818:Animals; D000917:Antibody Formation; D001853:Bone Marrow / Q000276:immunology*; D002478:Cells, Cultured; D006462:Hemolytic Plaque Technique; D008070:Lipopolysaccharides / Q000276:immunology; D011817:Rabbits; D012485:Salmonella typhi / Q000276:immunology
D008070:Lipopolysaccharides