Pharmacokinetic considerations in the haemodialysis of drugs.
Clinical pharmacists can deliver safer and more efficacious drug therapy to end-stage renal patients with knowledge and application of the pharmacokinetics of haemodialysis. The physical, chemical and pharmacokinetic properties of a drug will determine its degree of dialysability. These properties included water solubility, molecular weight, protein binding, volume of distribution, and the fraction, route and rate of drug elimination. Various dialysis-induced metabolic alterations must also be considered. With an understanding of these factors, the pharmacist can determine whether dosage adjustments are necessary and, if so, make the required calculations accurately.
D001711:Biotransformation; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D007700:Kinetics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D011485:Protein Binding; D006435:Renal Dialysis
D004364:Pharmaceutical Preparations