Preprandial and postprandial variations of insulin sensitivity in different times of the day assessed by the artificial pancreas in type I diabetics.
The aim of this study is to see whether changes in insulin need and in sensitivity to exogenous insulin occur in insulin-dependent diabetics receiving 3 daily non-isocaloric meals (at 0630, 1200 and 1730). In 9 type I diabetics submitted to the artificial pancreas control the insulin administered/dietary carbohydrates index (I/C) after breakfast (2.4 +/- 0.5) was significantly higher than after lunch (0.8 +/- 0.1) and after supper (0.84 +/- 0.1) (p less than 0.01). A trend to the reduced insulin sensitivity in the morning was also observed in fasting periods, when it was calculated as the ratio between blood glucose and insulin administered (BG/I): differences of BG/I however were not significant. It was concluded that diurnal variations of insulin sensitivity do occur in type I diabetic subjects, with an increment of insulin requirement in the morning.
D001786:Blood Glucose / Q000378:metabolism*; D002940:Circadian Rhythm; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D004435:Eating; D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000097:blood; D007332:Insulin Infusion Systems
D001786:Blood Glucose; D007328:Insulin