Salvage of the severely ischaemic limb by intra-arterial prostacyclin (PGI2) infusion. A case report.
A 75-year-old male patient with impending gangrene of the left lower limb due to advanced arteriosclerosis was treated with intra-arterial infusion of prostacyclin (PGI2). Pain at rest disappeared completely soon after treatment was started. Blood flow to the extremity measured by a Doppler velocity meter increased significantly during PGI2 infusion. Although some reduction in flow was found after termination of the infusion, the flow values up to 6 weeks after treatment were still markedly higher than pretreatment levels.
D000368:Aged; D011464:Epoprostenol / Q000627:therapeutic use*; D006801:Humans; D007261:Infusions, Intra-Arterial; D007511:Ischemia / Q000188:drug therapy*; D007866:Leg / Q000098:blood supply*; D008297:Male; D011453:Prostaglandins / Q000627:therapeutic use*; D012039:Regional Blood Flow
D011453:Prostaglandins; D011464:Epoprostenol