Treatment of stress response to laryngoscopy and intubation with fentanyl.
The cardiovascular response to laryngoscopy and intubation was investigated in lightly anaesthetised patients admitted to hospital for elective intracranial surgery. One group of patients was given fentanyl 5 microgram/kg body weight before induction with thiopentone and suxamethonium. The other group served as controls. Fentanyl treatment caused a significant attenuation of the blood pressure and pulse response to laryngoscopy and intubation. Different techniques for induction of anaesthesia are discussed in relation to the demands of neuroanaesthesia.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000601:surgery; D002986:Clinical Trials as Topic; D005260:Female; D005283:Fentanyl / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D007828:Laryngoscopy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011897:Random Allocation
D005283:Fentanyl