Alkylation with alkylhalides as a derivatization method for the gas chromatographic determination of acidic pharmaceuticals.
The various types of alkylation reactions with alkyl halides and their application in the gas chromatographic analysis of acidic compounds of pharmaceutical interest are reviewed. An extensive survey of the use of these methods for the analysis of various (classes of) compounds is given, with special reference to their determination in biological matrices.
D000478:Alkylation; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood / Q000652:urine; D000927:Anticonvulsants / Q000097:blood / Q000652:urine; D001463:Barbiturates / Q000097:blood / Q000652:urine; D001569:Benzodiazepines / Q000097:blood / Q000652:urine; D002849:Chromatography, Gas / Q000379:methods*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000097:blood* / Q000652:urine; D012463:Saliva / Q000032:analysis; D013449:Sulfonamides / Q000097:blood / Q000652:urine; D014970:Xanthines / Q000097:blood / Q000652:urine
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D001463:Barbiturates; D004364:Pharmaceutical Preparations; D013449:Sulfonamides; D014970:Xanthines; D001569:Benzodiazepines