Hepatitis B infection in patients with end stage renal disease: some characteristics and consequences.
Susceptibility to hepatitis B infection appears to be in part genetically determined. The HLA specificity Bw35 is commonly associated with a higher frequency of both transient and persistent hepatitis B surface antigen in the serum. Persistent hepatitis B surface antigenemia occurring in patients with end stage renal disease while on dialysis is associated with a poor prognosis and markedly decreased survival regardless of whether the individual is treated subsequently by chronic dialysis or by transplantation. We conclude that persistent hepatitis B surface antigenemia is not a contraindication to transplantation since outcome is not improved by management on hemodialysis.
D006514:Hepatitis B Surface Antigens / Q000009:adverse effects / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000276:immunology / Q000401:mortality*; D016030:Kidney Transplantation; D010641:Phenotype; D006435:Renal Dialysis
D006514:Hepatitis B Surface Antigens