title: [Captopril in severe arterial hypertension of childhood (authors transl)].
abstract: Twenty patients with severe arterial hypertension were treated with Captopril (an inhibitor of angiotensin 1 converting enzyme). Decrease in blood pressure occurred early and was sometimes important. Significant changes in plasma renin activity, plasma aldosterone and converting enzyme activity were observed. There was a significant inverse correlation between the action of Captopril on blood pressure and the level of extra-cellular volumes. Eighteen patients received long-term treatment (m = 10.05 +/- 1.32 mo.). Side-effects consisted of positive antinuclear antibodies and a possible kidney failure in cases with stenosis of the renal artery.
mesh_terms: D000293:Adolescent; D000328:Adult; D002216:Captopril / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D011392:Proline / Q000031:analogs & derivatives*; D013997:Time Factors
chemical_list: D011392:Proline; D002216:Captopril
vernacular_title: Captopril et hypertension artérielle sévère de l'enfant.