Effect of synthetic PAF-acether on human neutrophil function.
Synthetic PAF-acether was studied for its effect on human neutrophil migration and secretion. Based on checkerboard analysis, the factor is chemokinetic for neutrophils, but it also enhances ECF-stimulated chemotaxis. By itself, PAF-acether does not induce ECF or beta-glucuronidase secretion from neutrophils, but it causes a dose-dependent enhancement of release in the presence of zymosan. PAF-acether thus potentially modulates neutrophil functions during inflammatory events.
D000818:Animals; D002630:Chemotactic Factors / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D003165:Complement System Proteins / Q000494:pharmacology; D005966:Glucuronidase / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D016209:Interleukin-8; D008244:Lysophosphatidylcholines / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology; D010972:Platelet Activating Factor / Q000031:analogs & derivatives*
D002630:Chemotactic Factors; D016209:Interleukin-8; D008244:Lysophosphatidylcholines; D010972:Platelet Activating Factor; C026613:1-0-octadecyl 2-0-acetyl sn-glycero-3-phosphorylcholine; D003165:Complement System Proteins; D005966:Glucuronidase