Preliminary studies of the metabolic activity of purified suspensions of Mycobacterium leprae.
Mycobacterium leprae isolated from armadillo tissue incorporated radioactivity from D-(14C)glucose and (14C)protein hydrolysate. In the presence of glucose, the rate of incorporation of (14C)protein hydrolysate was increased. Uptake of glucose was inhibited by 2-deoxy-D-glucose and sodium azide; that of the amino acids was inhibited by puromycin and chloramphenicol and, weakly, by cycloheximide.
D000596:Amino Acids / Q000378:metabolism*; D001386:Azides / Q000494:pharmacology; D001426:Bacterial Proteins / Q000096:biosynthesis; D001692:Biological Transport; D002701:Chloramphenicol / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism*; D007700:Kinetics; D009166:Mycobacterium leprae / Q000378:metabolism*; D011691:Puromycin / Q000494:pharmacology; D019810:Sodium Azide
D000596:Amino Acids; D001386:Azides; D001426:Bacterial Proteins; D011691:Puromycin; D002701:Chloramphenicol; D019810:Sodium Azide; D003513:Cycloheximide; D005947:Glucose