title: A controlled field trial of an aluminum phosphate-adsorbed cholera vaccine in Calcutta.
abstract: A controlled field trial to determine the efficacy of a single dose of an aluminium phosphate-adsorbed cholera vaccine was conducted in Calcutta during 1975-77. An aluminium phosphate-adsorbed tetanus toxoid was used as the placebo. Follow-up of the immunized volunteers for a period of two years showed that the adsorbed cholera vaccine provided 100% protection to children under five years of age for 6 months, 88.9% for 12 months, and 91.7% for 18 months (P<0.05). The overall protection for all age groups was 58.5% for 18 months. There were no serious side effects following the anti-cholera inoculations.
mesh_terms: D000276:Adjuvants, Immunologic; D017607:Aluminum Compounds; D002675:Child, Preschool; D002771:Cholera / Q000517:prevention & control*; D022121:Cholera Vaccines; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007194:India; D007223:Infant; D008297:Male; D010710:Phosphates / Q000627:therapeutic use*
chemical_list: D000276:Adjuvants, Immunologic; D017607:Aluminum Compounds; D022121:Cholera Vaccines; D010710:Phosphates; C012714:aluminum phosphate