title: Effects of angiotensin II on blood pressure, plasma renin activity, and aldosterone in the fetal lamb.
abstract: 11 chronically catheterized fetal lamb preparations between 102 and 138 days of gestation (term 140--150 days) were studied after a continuous infusion of exogenous angiotensin II (0.25 microgram/kg/min). The pressor response to angiotensin II was delta 12.4 +/- 1.1 mm Hg. Plasma renin activity decreased from 6.33 +/- 2.49 ng/ml/h (mean and SEM) to 3.08 +/- 1.21 (p less than 0.05) after 30 min of the angiotensin II infusion. Plasma aldosterone showed a small increase from 5.13 +/- 0.9 to 7.34 +/- 1.22 ng/dl after 60 min (p less than 0.05) of the angiotensin II infusion. These results indicate that a pressor dose of angiotensin II will inhibit plasma renin activity and stimulate aldosterone secretion during the last trimester in the fetal sheep.
mesh_terms: D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000378:metabolism*; D005865:Gestational Age; D011247:Pregnancy; D012083:Renin / Q000097:blood*; D012756:Sheep
chemical_list: D000804:Angiotensin II; D000450:Aldosterone; D012083:Renin