title: Effect of insulin and epinephrine on some early oestrogenic responses in the rat uterus.
abstract: Oestradiol induces uterine eosinophilia and oedema, both in the intact immature rat and in the adult ovariectomized rat. These responses are decreased in ovariectomized-adrenalectomized adult rats, in adrenalectomized immature rats and in medullectomized immature rats. Pre-treatment with L-epinephrine restored both oestrogenic effects. Insulin inhibits oestrogen binding by uterine eosinophils and concurrently decreases oestrogen-induced uterine oedema and eosinophilia. These phenomena do not occur with inactive insulin. Insulin also induces blood eosinopaenia, suggesting an explanation for the findings in the uterus.
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D001345:Autoradiography; D001786:Blood Glucose / Q000032:analysis; D002369:Castration; D004804:Eosinophils / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology*; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D007328:Insulin / Q000494:pharmacology*; D007958:Leukocyte Count; D051381:Rats; D011919:Rats, Inbred Strains; D011960:Receptors, Estrogen / Q000187:drug effects; D014599:Uterus / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D011960:Receptors, Estrogen; D004958:Estradiol; D004837:Epinephrine