[Repair effect of p-aminobenzoic acid and aminobenzhydrazide].
A simple, safe and rapid experimental scheme is offered for screening chemical compounds for ability to activate DNA reparation in bacterial cells. As DNA-damaging agent use was made of cell heating. The structural integrity of genome was determined during subsequent 90-minute incubation of bacteria. It was demonstrated that without additions to the culture medium, the cells are unable to recover the damaged genome, while addition of the compounds in question stimulated the reparation of bacterial DNA. p-Aminobenzoic acid (10(-5) M) was more powerful than aminobenzhydrazide as regards the recovery of genome integrity.
D010129:4-Aminobenzoic Acid / Q000494:pharmacology*; D062365:Aminobenzoates / Q000494:pharmacology*; D000814:Aniline Compounds / Q000494:pharmacology*; D004260:DNA Repair / Q000187:drug effects*; D004269:DNA, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D005798:Genes, Bacterial / Q000187:drug effects
D062365:Aminobenzoates; D000814:Aniline Compounds; D004269:DNA, Bacterial; C034343:4-aminobenzhydrazide; D010129:4-Aminobenzoic Acid
Reparatsionnyĭ éffekt p-aminobenzoĭnoĭ kisloty i aminobenzgidrazida.