[Oxalate stone prophylaxis by alkalinizing therapy (author's transl)].
Hypocitraturia was found in 75% of oxalate stone formers, and combined with hypercalciuria in 27%. By short-term alkalinizing therapy (3 weeks) with sodium-potassium-citrate (Uralyt-U) a 118% increase in citrate- and a 29.5% decrease in calcium excretion could be achieved in 71 patients. There was no change in the 24 h urinary excretion of oxalate, urate, magnesium and phosphate. In 10 recurrent oxalate stone formers long-term (10 to 20 months) alkalinizing therapy was performed. The quantitative effect on the excretion of citrate and calcium remained unchanged. Seven patients, who have completed at least one year of therapy have had no recurrence of stones.
D000468:Alkalies / Q000627:therapeutic use*; D002118:Calcium / Q000652:urine; D002951:Citrates / Q000627:therapeutic use* / Q000652:urine; D019343:Citric Acid; D002986:Clinical Trials as Topic; D006801:Humans; D010070:Oxalates / Q000378:metabolism; D019815:Oxalic Acid; D014545:Urinary Calculi / Q000517:prevention & control*
D000468:Alkalies; D002951:Citrates; D010070:Oxalates; D019343:Citric Acid; D019815:Oxalic Acid; D002118:Calcium
Oxalatsteinprophylaxe durch Alkali-Therapie.