The genetic activity of dinitropyrenes in yeast: unusual dose response curves for induced mitotic gene conversion.
1,6-Dinitropyrene (1,6DNP) and 1,8-dinitropyrene (1,8DNP) were tested for their ability to induce mitotic gene conversion at the trp 5 and his 4 loci in the yeast Saccharomyces cerevisiae JD1. Both compounds were shown to be potent inducers of gene conversion in yeast, with 1,6DNP being somewhat more active than 1,8DNP. Unusual dose-response curves were obtained in that toxicity and genetic activity decreased at the higher concentrations examined. This reduction in genetic activity may reflect a decrease in the ability of yeast cells to convert the dinitropyrenes to their mutagenic forms when the concentration of the compounds exceeds a certain level.
D002470:Cell Survival / Q000187:drug effects; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005785:Gene Conversion / Q000187:drug effects*; D005838:Genotype; D008938:Mitosis / Q000187:drug effects; D009153:Mutagens / Q000494:pharmacology*; D011721:Pyrenes / Q000633:toxicity*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics*
D009153:Mutagens; D011721:Pyrenes; C033310:1,8-dinitropyrene; C033309:1,6-dinitropyrene; D004121:Dimethyl Sulfoxide