[Stimulation of nonspecific body resistance by mytilan, a polysaccharide isolated from the mussel. Crenomytilis grayanus].
The results of the study on the immunostimulant effect of mytilan, a polysaccharide isolated from Crenomytilus grayanus inhabiting the Sea of Japan are presented. It was shown that a single dose of the drug administered parenterally stimulated the natural protective reactions of the macroorganism evident from an increase in the leukocyte count in the peripheral blood of the experimental animals and the phagocytic activity of polymorphonuclear nuclear leukocytes. Mytilan stimulated humoral immunity. Its use brought about an increase in the hemolysin titers in response to administration of the sheep red blood cells card a significant increase in the number of antibody-forming cells as compared to the control. Mytiland had a preventive protective effect with regard to generalized pseudotuberculous and Salmonella infections. The drug increased the macroorganism resistance to both the psedotuberculous microbe and its toxins.
D000818:Animals; D049872:Bivalvia; D004353:Drug Evaluation, Preclinical; D007111:Immunity, Cellular / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects*; D008221:Lymphoid Tissue / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011134:Polysaccharides / Q000276:immunology* / Q000302:isolation & purification / Q000633:toxicity; D012480:Salmonella Infections / Q000188:drug therapy; D012486:Salmonella typhimurium; D013268:Stimulation, Chemical; D015012:Yersinia pseudotuberculosis Infections / Q000188:drug therapy
D011134:Polysaccharides; C030207:mytilan
Stimuliatsiia nespetsificheskoĭ rezistentnosti organizma mitilanom--polisakharidom, vydelennym iz midii Crenomytilis grayanus.