The effects of indomethacin in treated hypertensive patients.
1. Twelve treated hypertensive patients (ages 58-71 years) who had also been treated for joint disease participated in a randomized double-blind crossover placebo-controlled study to investigate the effects of indomethacin (25 mg three times daily) on blood pressure and biochemical parameters over a 6-week period. 2. Blood pressure was increased in all patients throughout the indomethacin treatment period (P less than 0.001)--average mean blood pressure increases were 9 mmHg (casual), 8 mmHg (supine), 10 mmHg (standing). 3. The blood pressure increase during indomethacin treatment was independent of the particular antihypertensive regimen in use. 4. Plasma aldosterone concentration was reduced by 50% (P less than 0.01), plasma renin activity was reduced by 43% (P = 0.102) and plasma urea concentration was increased by 17% (P less than 0.001) during indomethacin treatment. 5. The findings confirm that indomethacin impairs the blood pressure lowering effect of antihypertensive regimens.
D000368:Aged; D000450:Aldosterone / Q000097:blood; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood
D000959:Antihypertensive Agents; D000450:Aldosterone; D012083:Renin; D007213:Indomethacin