[Pteridine secretion as a marker for the proliferation of alloantigen-induced lymphocytes (author's transl)].
Pteridine levels from supernatants of mixed lymphocyte cultures and from urinary samples of allogeneic kidney transplant recipients were measured by high-pressure liquid chromatography. Marked proliferation of alloreactive lymphocytes was paralleled by an increased release of pteridines. In human allograft recipients rejection episodes were preceded at least 1-2 days by increased urinary neopterin levels. Thus, the urinary neopterin estimation is useful in the early detection of immunological rejections.
D002478:Cells, Cultured; D004261:DNA Replication; D006084:Graft Rejection; D006801:Humans; D007519:Isoantigens; D016030:Kidney Transplantation; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D011621:Pteridines / Q000378:metabolism* / Q000652:urine
D007519:Isoantigens; D011621:Pteridines
Pteridinausscheidung als Marker für alloantigen-induzierte Lymphozytenproliferation.