title: Influence of plasma glucose and insulin concentrations on carbohydrate oxidation in man.
abstract: The influence of both plasma glucose and insulin levels on the rate of carbohydrate oxidation was separately assessed in control subjects. During inhibition of endogenous insulin secretion by epinephrine + propranolol, glucose infusion produced an increase in carbohydrate oxidation when plasma glucose levels reached approximately 200 mg/100 ml. Addition of exogenous insulin to the glucose infusion was accompanied by a further rise in carbohydrate oxidation and a decrease in plasma glucose level. It was concluded that hyperglycemia without insulin response represents a compensatory mechanism which favours peripheral glucose utilization.
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D050260:Carbohydrate Metabolism; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism; D007328:Insulin / Q000378:metabolism* / Q000494:pharmacology; D000078790:Insulin Secretion; D008297:Male; D010084:Oxidation-Reduction; D011433:Propranolol / Q000494:pharmacology
chemical_list: D001786:Blood Glucose; D007328:Insulin; D011433:Propranolol; D005947:Glucose; D004837:Epinephrine