title: Isolation and partial characterization of insulin-glucagon liberin from bovine hypothalamus.
abstract: A tridecapeptide that enhances insulin and glucagon release from isolated islets of Langerhans was extracted from bovine hypothalami. Following the recommendation of the IUPAC-IUB Commission on Biological Nomenclature, the name Insulin-Glucagon Liberin (IGL) is proposed. The extraction, purification and partial characterization of the peptide is reported. The biological significance of hypothalamic IGL is still unknown but it could be a neurohumoral link between the hypothalamus and islet function, related to the regulation of fool intake and body weight.
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001681:Biological Assay; D002417:Cattle; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D005934:Glucagon / Q000378:metabolism*; D007031:Hypothalamus / Q000032:analysis*; D007328:Insulin / Q000378:metabolism*; D036341:Intercellular Signaling Peptides and Proteins; D007515:Islets of Langerhans / Q000378:metabolism; D010455:Peptides / Q000302:isolation & purification* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000596:Amino Acids; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C034184:insulin-glucagon liberin; D005934:Glucagon