title: Effects of prostacyclin on ultrastructural features of human platelets in vitro.
abstract: Examining platelets plasma-membrane by freeze-etching (FE)-technique irregularly place among the "particles", some larger formations, called by us "protuberances" can be seen. These protuberances may represent the stomata of the open canalicular system (OCS) and the morphological aspect of an exocytotic process. Addition of prostacyclin to platelet rich plasma (PRP) leads to a decrease of the average value of protuberances which is statistically significant in comparison to control platelets.
mesh_terms: D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D011464:Epoprostenol / Q000494:pharmacology*; D005089:Exocytosis; D005613:Freeze Etching; D006801:Humans; D066298:In Vitro Techniques; D011453:Prostaglandins / Q000494:pharmacology*
chemical_list: D011453:Prostaglandins; D011464:Epoprostenol