Hyperviscosity in the newborn lamb produces pertubation in glucose homeostasis.
We studied the effect of hyperviscosity on plasma glucose concentration, endogenous glucose production, and plasma insulin concentration in 12 term mixed breed newborn lambs. After a 7-hr fast, 0.45% saline was infused at a constant rate for 6 hr during which time hourly plasma glucose and 3-hourly plasma insulin concentrations were determined. A glucose turnover determination by the prime-constant infusion technique using 3H6 radiolabeled glucose was performed at a steady state. An exchange transfusion was then carried out using maternal packed red blood cells in six lambs to produce hyperviscosity and using maternal whole blood in six other lambs to maintain normoviscosity. After the exchange transfusion, a second study identical to that in the pre-exchange period was carried out. There was no significant difference in the mean plasma glucose concentration (mg/dl; mean +/- S.E.) between groups during the first turnover period (pre-exchange transfusion) [103 +/- 4.9 (normoviscous) versus 96 +/- 4.8 (Hyperviscous)], but during the postexchange transfusion turnover period, the plasma glucose concentration was lower in the hyperviscous than in the normoviscous group [89 +/- 4.3 (Normoviscous) versus 76 +/- 4.0 (Hyperviscous)] (P less than 0.05.) Endogenous glucose production declined from the first to the second glucose turnover determination in both groups, but there was no significant difference between the normoviscous and hyperviscous groups. Plasma insulin concentrations were similarly low in both groups suggesting suppression in the fasted state. The data suggest that the hyperviscosity acts as an independent variable to depress plasma glucose concentration, the mechanism of which is still undefined.
D000818:Animals; D000831:Animals, Newborn / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis*; D001809:Blood Viscosity; D005078:Exchange Transfusion, Whole Blood; D006706:Homeostasis; D007328:Insulin / Q000097:blood; D012756:Sheep
D001786:Blood Glucose; D007328:Insulin