title: Renovascular hypertension in black patients.
abstract: In a 10-year period, 7200 of 19,000 black hypertensive adults in the University of Cincinnati Medical Center were referred to the Hypertension Service. In selected patients, intravenous urograms (1038) and renal arteriograms (238) were performed; 47 cases of renovascular hypertension (0.65% of the referred group and 0.25% of the entire sample) were identified. Atherosclerosis (32 patients) and fibromuscular dysplasia (11) were the most common causes of renal artery obstruction. Other lesions included traumatic thrombosis (2), Leriche syndrome (1), and postrenal transplant anastomotic thrombosis (1). Twenty-four patients were operated on (6 cured, 14 improved, 4 dead) and 23 treated medically (18 improved, 2 unimproved, 3 dead). Surgical mortality was 0. Follow-up exceeded 5 years in 25 patients. Extrarenal vascular lesions were found in 30 patients and accounted for six of seven deaths. Renal vein renin ratios greater than 1.5:1 (affected to unaffected side) predicted successful surgery in 14 patients, but eight of nine operated patients with ratios less than 1.5:1 also had favorable results. Factors in addition to renin assay were weighed before surgery was recommended. Since renovascular hypertension is rare in adult blacks, intensive investigation for this entity is justified only in patients with distinct suggestive findings. Treatment results in blacks are similar to those in white cohorts.
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D003430:Cross-Sectional Studies; D006801:Humans; D006977:Hypertension, Renal / Q000453:epidemiology*; D006978:Hypertension, Renovascular / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy; D008875:Middle Aged; D012078:Renal Artery Obstruction / Q000453:epidemiology; D012083:Renin / Q000097:blood; D014481:United States
chemical_list: D012083:Renin