Enhanced lymphoma incidence in BALB/c mice after ultraviolet light treatment.
Following UV irradiation of BALB/c mice three times a week for 9 months, lymphatic leukemia or reticulosarcoma developed in 44 (12%) of 378 mice whose backs were shaved and whose ears were intact. Only 11 (5%) of 224 UV-irradiated mice whose backs were shaved and whose ears were removed developed lymphomas. Among 311 unirradiated mice whose backs were shaved, 9 lymphomas (3%) occurred. The diagnosis of leukemia or reticulosarcoma was confirmed by microscopy and transplantation. Among irradiated mice, ear tumors developed in 24% of the mice with intact ear, whereas skin tumors developed on the shaved backs in 4% of the mice whose ears were removed and also in 4% of the mice with intact ears.
D000818:Animals; D004428:Ear Neoplasms / Q000209:etiology; D007942:Leukemia, Experimental / Q000209:etiology; D007945:Leukemia, Lymphoid / Q000209:etiology*; D007953:Leukemia, Radiation-Induced; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000209:etiology; D009381:Neoplasms, Radiation-Induced; D012878:Skin Neoplasms / Q000209:etiology; D014466:Ultraviolet Rays / Q000009:adverse effects*