[Participation of glucocorticoids and insulin in changes in energy metabolism in the spleen of irradiated rats].
Irradiation of rats with a fast neutron flow (0.5 Gy twice with a 7-day interval induces an increase in the content of 11-oxycorticosteroids and insulin in the blood plasma, the hormone ratio changing with glucocorticoids prevailing. Simultaneously oxidative phosphorylation is inhibited and the pool of adenylic nucleotides lowers in the spleen. Multiple hydrocortisone injections to the irradiated animals intensify the effect of the neutron action, and the administration of insulin (alone or in combination with hydrocortisone) normalizes the energy metabolism parameters to a considerable extent.
D015062:11-Hydroxycorticosteroids / Q000097:blood*; D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects / Q000528:radiation effects*; D006854:Hydrocortisone / Q000494:pharmacology; D007328:Insulin / Q000097:blood* / Q000494:pharmacology; D008297:Male; D009502:Neutrons; D010085:Oxidative Phosphorylation / Q000187:drug effects / Q000528:radiation effects; D051381:Rats; D013154:Spleen / Q000378:metabolism / Q000528:radiation effects*
D015062:11-Hydroxycorticosteroids; D007328:Insulin; D006854:Hydrocortisone
Ob uchastii gliukokortikoidov i insulina v izmenenii énergeticheskogo obmena v selezenke obluchennykh krys.