Mutagenicity and DNA-modifying activity of 2-nitropropane.
The results presented herein confirm the mutagenicity in Salmonella of 2-nitropropane and the relative inactivity of 1-nitropropane. The lack of mutagenicity of 1- and 2-aminopropane is also reported. In addition, we have demonstrated the in vitro DNA-modifying activity of 2-nitropropane, and present evidence to suggest that genetic activity of this nitroalkane may not be dependent on the enzymic reduction of the nitro function to the corresponding hydroxylamine.
D000473:Alkanes / Q000494:pharmacology*; D004277:DNA, Single-Stranded / Q000378:metabolism*; D066298:In Vitro Techniques; D009152:Mutagenicity Tests; D009153:Mutagens; D009595:Nitroparaffins / Q000378:metabolism / Q000494:pharmacology*; D011407:Propane / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D012486:Salmonella typhimurium / Q000235:genetics
D000473:Alkanes; D004277:DNA, Single-Stranded; D009153:Mutagens; D009595:Nitroparaffins; C016617:2-nitropropane; D011407:Propane