[Radiobiologic considerations about further development of whole-body irradiation with subsequent bone marrow transplantation applied during the treatment of acute leukemia (author's transl)].
The results achieved hitherto with whole-body irradiation in case of acute leukemia are examined with respect to the optimization criteria of a radiotherapy. The most important failure risk is the recurrence which occurs in more than 50% of all cases, then follows the interstitial pneumonia. The authors think that an increase of the total dose, the adaption of the dose distribution to the distribution of leukemia cells in the body, and a higher fractionation of the total dose are approaches for improving the therapy results.
D000208:Acute Disease; D016026:Bone Marrow Transplantation; D006801:Humans; D007938:Leukemia / Q000532:radiotherapy* / Q000628:therapy; D011658:Pulmonary Fibrosis / Q000150:complications; D011879:Radiotherapy Dosage; D014180:Transplantation
Strahlenbiologische Uberlegungen zur Weiterent wicklung der Ganzkörperbestrahlung bei der Behandlung akuter Leukämien mit anshliessender Knochenmarktransplantation.