Enteral administration of insulin in the rat.
1 The effect of the surfactant, Cetomacrogol 1000, on the absorption of insulin across the rectal mucosa has been studied. 2 Rectal administration of microenemata containing Cetomacrogal 1000 and insulin causes a rise in the plasma concentration of insulin and a consequent fall in the blood glucose concentration in diabetic and non-diabetic rats. 3 The hypoglycaemic response is dependent on both the concentration of surfactant and the dose of insulin administered. 4 The results suggest that the transport of insulin across the rectal mucosa is facilitated by Cetomacrogal 1000.
D000818:Animals; D002592:Cetomacrogol / Q000008:administration & dosage*; D004733:Enema; D007328:Insulin / Q000008:administration & dosage* / Q000378:metabolism; D007408:Intestinal Absorption; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D051381:Rats; D012007:Rectum
D007328:Insulin; D011092:Polyethylene Glycols; D002592:Cetomacrogol