Effects of alpha-methylnoradrenaline and alpha-methyldopamine in reserpine-induced ulcers in rats.
alpha-Methyldopamine and alpha-methylnoradrenaline administered intraperitoneally afforded significant protection in reserpine-induced ulcers in rats. The optimal doses were 2 and 4 mg/kg. Lower and higher doses were less effective. alpha-Methyldopamine and alpha-methyl-noradrenaline probably act by reestablishing the normal adrenergic tone which is diminished in reserpine-induced ulcers.
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003846:Deoxyepinephrine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D004298:Dopamine / Q000031:analogs & derivatives*; D008297:Male; D008771:Nordefrin / Q000494:pharmacology / Q000627:therapeutic use*; D009638:Norepinephrine / Q000031:analogs & derivatives*; D051381:Rats; D012110:Reserpine; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
D000897:Anti-Ulcer Agents; C023492:alpha-methyldopamine; D012110:Reserpine; D003846:Deoxyepinephrine; D008771:Nordefrin; D004298:Dopamine; D009638:Norepinephrine