Immunohistochemical characterization of renin-containing cells in the human juxtaglomerular apparatus during embryonal and fetal development.
Thirty kidneys from nine embryos, 20 fetuses, and one full-term baby were examined for their renin content by immunofluorescence and the peroxidase antiperoxidase method, using an antihuman renin antiserum. Renin-containing cells were found in the early metanephros (5-week-old fetuses). Most of them were located in the wall of well-developed renal arteries in the vicinity of the prospective vascular pole of the glomeruli. In the poorly differentiated peripheral renal cortex, intracellular fluorescence was seen in nearby arterioles of pocket-like s-shaped tubules. Rarely, labeled cells were found in the wall of major branches of renal arteries. In all locations, the renin-containing cells appear to be clearly linked to the development of the renal vascular system.
D002454:Cell Differentiation; D004622:Embryo, Mammalian / Q000032:analysis* / Q000166:cytology; D005260:Female; D005333:Fetus / Q000032:analysis* / Q000166:cytology; D005455:Fluorescent Antibody Technique; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D007606:Juxtaglomerular Apparatus / Q000032:analysis* / Q000166:cytology; D007672:Kidney Cortex / Q000166:cytology; D007679:Kidney Medulla / Q000166:cytology; D011247:Pregnancy; D012083:Renin / Q000276:immunology
D007106:Immune Sera; D012083:Renin