title: [Treatment and prevention of recurrence of duodenal ulcer with pirenzepin and cimetidine].
abstract: The effect of pirenzepine and cimetidine on healing, symptoms, and relapse rate of duodenal ulcer was studied in a placebo controlled double blind trial. With regard to symptoms, cimetidine (1 g daily) was superior at the beginning of therapy to a low dose of pirenzepine (75 mg daily) and to placebo. No significant differences in ulcer healing were found between the 3 treatment groups. The relapse rate after treatment with pirenzepine was lower than after treatment with cimetidine.
mesh_terms: D000328:Adult; D000368:Aged; D001570:Benzodiazepinones / Q000627:therapeutic use*; D002927:Cimetidine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000517:prevention & control; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D010890:Pirenzepine; D012008:Recurrence
chemical_list: D001570:Benzodiazepinones; D006146:Guanidines; D010879:Piperazines; D010890:Pirenzepine; D002927:Cimetidine
vernacular_title: Behandlung und Rezidivprophylaxe des Ulcus duodeni mit Pirenzepin und Cimetidin.