[Experimental protection of the myocardium from anoxic damage by a weak solution of formalin].
Experiments on 80 noninbred rats and 135 rabbits have demonstrated for the first time the possibility of cardioplegia induction with a 0.25% formaldehyde solution. In experimental heterotopic heart transplantation, cardiac function could be restored by perfusion of donor blood within up to 3 hours after cardioplegia. This was associated with restitution of sinus rhythm and direct electrical excitability, with normalization of the intraventricular pressure (for the model described). Histological, histochemical, electron microscopic and electrophysiological studies have shown that low concentrations of formaldehyde solution inhibit myocardial energy metabolism and reversibly inhibit the enzymatic activity, preventing proteolysis and thus contributing to the preservation of heart viability.
D000818:Animals; D002682:Chinchilla; D003327:Coronary Disease / Q000517:prevention & control*; D005557:Formaldehyde / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D016027:Heart Transplantation; D009926:Organ Preservation / Q000379:methods; D011817:Rabbits; D051381:Rats; D014182:Transplantation, Autologous
D005557:Formaldehyde
Zashchita miokarda slabym rastvorom formalina ot anoksicheskikh povrezhdeniĭ v éksperimente.