A comparative study of disopyramide and procainamide in the treatment of myotonia in myotonic dystrophy.
Ten patients with myotonic dystrophy were allocated at random to treatment with disopyramide and procainamide in a cross-over trial. Disopyramide was found to be at least as effective as procainamide in the relief of myotonia; and two patients who could not tolerate procainamide both tolerated disopyramide.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004206:Disopyramide / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009223:Myotonic Dystrophy / Q000188:drug therapy*; D011342:Procainamide / Q000627:therapeutic use; D011725:Pyridines / Q000627:therapeutic use*; D011897:Random Allocation
D011725:Pyridines; D004206:Disopyramide; D011342:Procainamide