The effects of blood sera from calf fetuses in various periods of fetal life on skin allograft survival time in mice and on human lymphocyte proliferation in vitro.
The inhibitory effects of blood sera from calf fetuses in different periods of fetal life on human lymphocyte proliferation in short-term cultures and on the skin-allograft survival time in mice (C57Bl/6 leads to R3) were investigated. The lymphocytes mitosis inhibition and the decrease incorporation of [3H]thymidine into DNA of lymphocyte as well as the mouse skin-allograft survival-time prolongation were observed. It was found that the inhibiting activity of the sera decreased with the increase of age of the fetuses.
D000367:Age Factors; D000818:Animals; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D005312:Fetal Blood; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008938:Mitosis / Q000187:drug effects; D011247:Pregnancy; D016038:Skin Transplantation; D014184:Transplantation, Homologous