[Carbohydrate infusion in internal diseases. A comparative study in metabolically health, liver diseased and diabetic patients. VII. Infusions of a glucose-fructose-xylitol mixture (relationship 1:2:1) over 48 hours].
3 groups (6 control persons, 6 patients with liver cirrhosis, 6 patients with diabetes mellitus) were infused with 20% (w/v) carbohydrate mixture (glucose/fructose/xylitol, 1:2:1) for 48 hours. The metabolical status was controlled in defined intervals by means of 39 different laboratory parameters. The infusion rate was supposed to be 0.25 g carbohydrates/kg B. W. and hour. There were no significant changes in blood glucose levels in any of the 3 groups. However we could observe a slight but constant increase in lactate and triglyceride concentrations. Free fatty acids and keton bodies were suppressed on a low level. Only the diabetics showed a significant renal carbohydrate loss with up to 15% of the amount administered. No clinically relevant side effects were observed.
D000328:Adult; D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000628:therapy*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005632:Fructose / Q000008:administration & dosage* / Q000097:blood; D005947:Glucose / Q000008:administration & dosage*; D005950:Glucose Solution, Hypertonic / Q000008:administration & dosage*; D006801:Humans; D007263:Infusions, Parenteral; D007328:Insulin / Q000097:blood; D007657:Ketone Bodies / Q000097:blood; D007773:Lactates / Q000097:blood; D008055:Lipids / Q000097:blood; D008103:Liver Cirrhosis / Q000628:therapy*; D011773:Pyruvates / Q000097:blood; D014993:Xylitol / Q000008:administration & dosage* / Q000097:blood
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D005950:Glucose Solution, Hypertonic; D007328:Insulin; D007657:Ketone Bodies; D007773:Lactates; D008055:Lipids; D011773:Pyruvates; D005632:Fructose; D005947:Glucose; D001663:Bilirubin; D014993:Xylitol
Kohlenhdratinfusion bei internistischen Erkrankungen. Eine vergleichende Studie bei stoffwechselgesunden, leberkranken und diabetischen Patienten. VII. Infusion eines Glukose-Fruktose-Xylit-Gemisches (Verhältnis 1:2:1) über 48 Stunden.