Appearance of dense granules in the rough endoplasmic reticulum of the juxtaglomerular cells in mice administered with captopril.
Captopril [1-(D-3-mercapto-2-methyl-1-oxopropyl)-L-proline (S,S)] is now known to be an inhibitor of angiotensin-converting enzyme. In male mice, the juxtaglomerular cells were examined by electron microscopy 42 h after administration of captopril. Numerous dense granules appeared in the rough endoplasmic reticulum of these cells.
D000818:Animals; D002216:Captopril / Q000494:pharmacology*; D004721:Endoplasmic Reticulum / Q000648:ultrastructure*; D006056:Golgi Apparatus / Q000648:ultrastructure; D007606:Juxtaglomerular Apparatus / Q000187:drug effects / Q000648:ultrastructure*; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D011392:Proline / Q000031:analogs & derivatives*
D011392:Proline; D002216:Captopril