Hypoventilation and elevation of end-expiratory pressure release a substance which relaxes isolated arteries and disaggregates platelets in the presence of cyclooxygenase inhibitors.
A prostacyclin-like substance was detected by bioassay in the blood of dogs and cats during hypoventilation and increased end-expiratory pressure. This biologically active material, most likely originating from lungs, relaxed isolated vascular strips and disaggregated platelets. Its release was not prevented by indomethacin or aspirin. Biological activity was not abolished by 10 min incubation of blood at 38 degrees C. Although the identity of the substance has not been established the release of a biologically active prostacyclin-like material might play a role in circulatory adaptation to disturbed ventilatory function.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001681:Biological Assay; D002415:Cats; D002417:Cattle; D004285:Dogs; D011464:Epoprostenol / Q000097:blood* / Q000494:pharmacology; D007040:Hypoventilation / Q000097:blood*; D007213:Indomethacin / Q000494:pharmacology; D008176:Lung Volume Measurements; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D011453:Prostaglandins / Q000097:blood*; D011817:Rabbits; D051381:Rats
D011453:Prostaglandins; D011464:Epoprostenol; D001241:Aspirin; D007213:Indomethacin