The induction of mitotic gene conversion in the yeast, Saccharomyces cerevisiae JD1 by 4-chloromethylbiphenyl (4CMB), benzyl chloride (BC) and 4-hydroxymethylbiphenyl (4HMB).
The induction of mitotic gene conversion by 4CMB, BC and 4HMB was studied in both log-phase and stationary-phase cultures of the yeast, Saccharomyces cerevisiae JD1. Assays were performed both in the presence and in the absence of S9 microsomal fraction obtained from a liver homogenate from rats pretreated with Aroclor 1254. Exposure of both stationary-phase and log-phase cultures to 4CMB and BC resulted in an increase in mitotic gene conversion, both in the presence and in the absence of a microsomal activation system; the magnitude of response was greater in stationary-phase cultures. 4HMB did not increase the gene conversion frequency in log-phase or stationary-phase cultures.
D000818:Animals; D001593:Benzyl Compounds / Q000494:pharmacology*; D001711:Biotransformation; D001713:Biphenyl Compounds / Q000494:pharmacology*; D005785:Gene Conversion; D008862:Microsomes, Liver / Q000378:metabolism; D008938:Mitosis; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D051381:Rats; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics*
D001593:Benzyl Compounds; D001713:Biphenyl Compounds; D009153:Mutagens; C033488:4-hydroxymethylbiphenyl; C033487:4-chloromethylbiphenyl; C021292:benzyl chloride