[Effect of hydrocortisone and insulin on the adenine nucleotide content of the spleens of alloxan diabetes rats].
The synthesis rate and the content of free acid-soluble adenylic ribonucleotides decrease in the spleen of rats with alloxane diabetes. The above changes are normalized under the influence of insulin administered to these animals and are aggravated under the effect of hydrocortisone. When the both hormones are administered simultaneously, insulin weakens the inhibitory effect of hydrocortisone.
D000227:Adenine Nucleotides / Q000378:metabolism*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000378:metabolism*
D000227:Adenine Nucleotides; D007328:Insulin; D006854:Hydrocortisone
Vliianie gidrokortizone i insulina na soderzhanie adeninovykh nukleotidov v selezenke krys s alloksanovym diabetom.