[Glucose metabolic clearance during acute cold exposure. Effects of insulin and glucagon (author's transl)].
The glucose metabolic clearance (CMG) was measured by using tritiated glucose in dogs either resting at neutral ambient temperature (TaN = + 25 degrees C) or shivering in the cold (TaC = 21 degrees C). Between two control periods, insulin and/or glucagon deficiencies were provoked by jugular somatostatin infusion without or with portal insulin (glucagon deficiency) or glucagon infusion (insulin deficiency). It was observed that: (1) In absence of hormonal deficiency, CMG was about twice as high at TaC as at TaN; (2) A simultaneous insulin and glucagon deficiency decreased CMG only at TaC; (3) Both at TaN and TaC, the CMG was either decreased or increased by insulin or glucagon deficiency respectively; (4) The magnitude (16-30%) of the hormonal-induced variations were small by comparison with the increase induced by the lowering of the ambient temperature.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003080:Cold Temperature; D004285:Dogs; D005260:Female; D005934:Glucagon / Q000502:physiology*; D007328:Insulin / Q000502:physiology*; D008657:Metabolic Clearance Rate
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon
La clairance métabolique du glucose pendant l'exposition aiguë au froid. Effets de l'insuline et du glucagon.