title: Fibronectin distribution pattern and the three-dimensional growth behavior of mammalian cells under anchorage-independent conditions.
abstract: Several types of normal diploid cells, established "normal" cells, and transformed cells of human and rodent origin have been studied with reference to cell surface fibronectin distribution and their anchorage-independent growth behavior. All cell types that showed intercellular and fibrillar surface fibronectin were anchorage-dependent for growth. Lack of surface fibrillar fibronectin in spontaneously or virus-transformed cells and cells of neoplastic origin was accompanied by anchorage-independent growth potential. The degree of three-dimensional organization of cells under anchorage-independent growth conditions was dependent on the amount of intercellular fibronectin. The significance of these observations to in vivo tumor growth is discussed.
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002455:Cell Division; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D006224:Cricetinae; D003470:Culture Media; D005353:Fibronectins / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D006801:Humans; D051379:Mice; D013499:Surface Properties
chemical_list: D003470:Culture Media; D005353:Fibronectins