Effect of the TP5 analogue of thymopoietin on the rejection of male skin by aged and thymectomized female mice.
Although young adult C3H/HeJ (C3H) females do not reject C3H male skin grafts, C3H females older than 1 year commonly do so, as also do many thymectomized, young adult C3H females. Therapy with TP5, a synthetic pentapeptide analogue of thymopoietin which has biological properties of the parent molecule, substantially reduced the capacity of aged C3H females and of thymectomized, young C3H females to reject C3H male skin.
D000375:Aging; D000818:Animals; D000950:Antigens, Ly; D005260:Female; D006084:Graft Rejection / Q000187:drug effects*; D006728:Hormones / Q000494:pharmacology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H / Q000276:immunology*; D010446:Peptide Fragments / Q000494:pharmacology*; D016038:Skin Transplantation; D013934:Thymectomy; D016305:Thymopentin; D013946:Thymopoietins / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*
D000950:Antigens, Ly; D006728:Hormones; D010446:Peptide Fragments; D013946:Thymopoietins; D013951:Thymus Hormones; D016305:Thymopentin