title: The mode of action of nosiheptide (multhiomycin) and the mechanism of resistance in the producing organism.
abstract: The mode of action of nosiheptide (multhiomycin) on bacterial protein synthesis is closely similar to that of thiostrepton. Both antibiotics inhibit functions of elongation factors Tu and G and greatly reduce the synthesis of guanosine penta- and tetraphosphates in response to stringent factor. Furthermore, the actinomycetes which produce these antibiotics defend themselves against their products in similar fashion. This involves specific pentose-methylation of 23S ribosomal RNA.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000096:biosynthesis; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D008745:Methylation; D010429:Pentoses / Q000494:pharmacology; D010445:Peptide Elongation Factors / Q000378:metabolism; D012270:Ribosomes / Q000187:drug effects*; D013302:Streptomyces / Q000187:drug effects / Q000378:metabolism; D013844:Thiazoles / Q000494:pharmacology; D013883:Thiostrepton / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D010429:Pentoses; D010445:Peptide Elongation Factors; D013844:Thiazoles; C014134:nosiheptide; D013883:Thiostrepton