The regulation of eIF-2 function protein synthesis initiation.
The regulation of eIF-2 activity during protein synthesis initiation has been postulated to involve phosphorylation/dephosphorylation mechanisms and/or the participation of ancillary protein factors. Both mechanisms would affect directly the binding of initiator methionyl-tRNAi by eIF-2. Recent data concerning the phosphorylation state of eIF-2 in hemin-deficient lysates and other covalent modifications which alter the efficiency of eIF-2 utilization, however, suggest that modulation of eIF-2 activity is more complex, and involves alteration of its catalytic recycling.
D000818:Animals; D015852:Eukaryotic Initiation Factor-2; D010084:Oxidation-Reduction; D010085:Oxidative Phosphorylation; D010442:Peptide Chain Initiation, Translational; D010448:Peptide Initiation Factors / Q000502:physiology*; D014176:Protein Biosynthesis; D011506:Proteins / Q000502:physiology*
D015852:Eukaryotic Initiation Factor-2; D010448:Peptide Initiation Factors; D011506:Proteins