History and genealogy of the H-2Kb mutants from the C57BL/6Kh colony.
The genealogy of 14 H-2Kb mutations arising spontaneously in the C57BL/6Kh colony is presented together with data from skin-graft monitoring and husbandry procedures. Eight of the 14 mutations have phenotypic and structural similarities, but the pedigree analysis and evaluation of the histocompatibility genetics of their sibs and ancestors strongly indicate that they represent recurring mutational events rather than the segregation of a single mutation throughout the colony.
D000822:Animal Husbandry / Q000379:methods; D000818:Animals; D005260:Female; D006183:H-2 Antigens / Q000235:genetics*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D009154:Mutation; D010641:Phenotype; D016038:Skin Transplantation; D013997:Time Factors
D006183:H-2 Antigens