title: Characterization of two mutant strains of Saccharomyces cerevisiae deficient in coproporphyrinogen III oxidase activity.
abstract: Two new haem-deficient mutants of Saccharomyces cerevisiae were isolated on the basis of their catalase deficiency. Mutant H11 accumulated and excreted coproporphyrin III and was completely deficient in haem; the cell-free extract had no coproporphyrinogen oxidase activity. Mutant H12 accumulated uroporphyrin to coproporphyrin III and excreted coproporphyrin III, and contained a small amount of haem; the cell-free extract had a residual coproporphyrinogen oxidase activity. The two mutations were allelic and the mutant phenotypes were under the control of a single, recessive nuclear gene.
mesh_terms: D003304:Coproporphyrinogen Oxidase / Q000378:metabolism*; D006418:Heme / Q000096:biosynthesis; D009154:Mutation; D010088:Oxidoreductases / Q000378:metabolism*; D010641:Phenotype; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics*
chemical_list: D006418:Heme; D010088:Oxidoreductases; D003304:Coproporphyrinogen Oxidase