[Cholera vibrio culture in a fermenter with automatic control of a number of parameters].
The cultivation of V. cholerae was carried out in casein broth in a fermenter. 2 kinds of cultivation conditions were compared. The results thus obtained indicate that the cultivation of V. cholerae under the conditions of the controlled level of dissolved oxygen (pO2--50%) ensures the optimum conditions for proliferation and the high yield of biomass; it also allows obtaining vaccine whose immunogenic properties are not inferior to those of the WHO reference vaccine.
D001428:Bacterial Vaccines / Q000302:isolation & purification; D001431:Bacteriological Techniques / Q000295:instrumentation; D003470:Culture Media / Q000378:metabolism; D005285:Fermentation; D006863:Hydrogen-Ion Concentration; D014734:Vibrio cholerae / Q000254:growth & development* / Q000276:immunology
D001428:Bacterial Vaccines; D003470:Culture Media
Kultivirovanie kholernykh vibrionov v fermentere s avtomaticheskim kontrolem riada parametrov.