Effects of suprachiasmatic nuclei (SCN) lesions on the circadian variations in PRA and IRI level in the rat.
PRA and IRI were determined at 8 a.m., 4 p.m. and midnight (MN) in SCN lesioned and intact rats. In control animals, PRA was highest at 4 p.m., while IRI showed higher values at 8 a.m. and MN. SCN lesions abolished circadian variations in both PRA and IRI, diminishing significantly PRA in comparison with intact rats.
D000818:Animals; D001927:Brain Diseases / Q000503:physiopathology*; D002940:Circadian Rhythm; D007328:Insulin / Q000378:metabolism*; D008297:Male; D051381:Rats; D012083:Renin / Q000097:blood*; D013997:Time Factors
D007328:Insulin; D012083:Renin