Coliphage 186 infection requires host initiation functions dnaA and dnaC.
We show that coliphage 186 infection is dependent upon host initiation functions, dnaA and dnaC, which differentiates the phage from lambda and P2. The possibility is therefore entertained that the delay in 186 replication seen after infection of UV-irradiated bacterial cells reflects the temporary unavailability of one or both these functions. Infections with P1 and Mu need host dnaC but not dnaA and show some sensitivity to preirradiation of the host but are not as sensitive as 186.
D003090:Coliphages / Q000254:growth & development*; D004261:DNA Replication; D004269:DNA, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000502:physiology* / Q000528:radiation effects; D014466:Ultraviolet Rays; D014779:Virus Replication
D004269:DNA, Bacterial