[Uptake of 14C-nicotinic acid by membrane structures of rat tissue in alloxan diabetes with insulin administration].
The uptake of nicotinic acid by erythrocytes, hepatocytes and inverted small intestine sacs of rats with alloxane diabetes was studied as affected by insulin. It is established that a disturbance of the pancreas endocrine function caused by the administration of alloxane to rats inhibits the accumulation of [14C]nicotinic acid in all the studied structures. Insulin administered to rats with alloxane diabetes stimulates the acid uptake by erythrocytes and hepatocytes, but has no effect on accumulation of the vitamin in tissues and serous fluid of inverted empty intestine sacs. An assumption is advanced that under alloxane diabetes the membrane transport of nicotinic acid is disturbed and it may be partially normalized by the insulin administration. The efficiency of the hormone influence on the vitamin uptake by the structures under study changes essentially against a background of the actinomycin D and cycloheximide action.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002250:Carbon Radioisotopes; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology*; D007421:Intestine, Small / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D009539:Nicotinic Acids / Q000378:metabolism*; D051381:Rats
D002250:Carbon Radioisotopes; D007328:Insulin; D009539:Nicotinic Acids
Pogloshchenie [14C]nikotinovoĭ kisloty membrannyme strukturami tkaneĭ krys s alloksanovym diabetom pri vvedenii insulina.