Effects of whole-body gamma irradiation on oxygen transport by rat erythrocytes.
In this work, we studied the influence of whole-body gamma irradiation (8 Gy) upon oxygen transport by erythrocytes, through the erythrocyte count and related parameters, and through the factors affecting the oxygen affinity of hemoglobin. The oxygen affinity of hemoglobin is increased from day D + 5 after irradiation, and a severe erythropenia develops from day D + 8. These modifications probably result in tissue hypoxia via diminished oxygen transport from lungs to tissues, and decreased oxygen release from oxyhemoglobin in tissues.
D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate / Q000097:blood; D000818:Animals; D001692:Biological Transport; D004163:Diphosphoglyceric Acids / Q000097:blood; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000378:metabolism / Q000528:radiation effects*; D005720:Gamma Rays; D006452:Hemoglobinometry; D007700:Kinetics; D010100:Oxygen / Q000097:blood*; D011839:Radiation, Ionizing; D051381:Rats; D014916:Whole-Body Irradiation
D004163:Diphosphoglyceric Acids; D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate; D010100:Oxygen