Multidisciplinary treatment of advanced stages of embryonal rhabdomyosarcoma in children.
Twenty-eight previously untreated patients with embryonal rhabdomyosarcoma, stages II to IV, were treated with the T-6 induction protocol and maintained on the T-2 protocol. The T-6 protocol consisted of simultaneous administration of drugs and irradiation, given in 3 parts each separated by an obligatory period of rest. Twenty-four of the 28 patients (85.7%) survived 4 to 44 months, with a median follow-up of 24 months; 18 (64%) have been in continuous disease-free status. The immediate toxicity of the T-6 induction was severe and required intensive supportive care. To date, the results from the T-6 induction protocol were more effective than those achieved with the T-2 protocol.
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D012208:Rhabdomyosarcoma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D012983:Soft Tissue Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy
D000970:Antineoplastic Agents