Trials with the cerviscan experimental prescreening device on polylysine-prepared slides.
A blind trial was carried out to evaluate the performance of the Cerviscan experimental automated cytology prescreening system on cervical scrape specimens prepared by a suspension-polylysine-hematoxylin preparation method. One hundred twenty-nine specimens of various cytologic gradings were automatically scanned, and objects detected as "suspect" were examined and classified. The overall results of the trial showed a false-negative specimen rate of 4% and a false-positive specimen rate of 18%. The mean number of false-positive signals from normal specimens was 24 per 20,000-cell sample. Major problems were the number of false-positive signals caused by the hematoxylin stain and the number of specimens rejected as inadequate by the scanner. A random partition test was carried out to estimate the ROC performance curve for the system.
D002467:Cell Nucleus / Q000648:ultrastructure; D002584:Cervix Uteri / Q000166:cytology*; D002986:Clinical Trials as Topic; D003581:Cytodiagnosis / Q000295:instrumentation*; D003593:Cytoplasm / Q000648:ultrastructure; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D011107:Polylysine; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*; D014626:Vaginal Smears
D011107:Polylysine