A clinical comparison of tobramycin and gentamicin sulfate in the treatment of ocular infections.
We evaluated the safety and efficacy of tobramycin and gentamicin sulfate ophthalmic solutions in the treatment of patients with bacterial infections of the conjunctivas. In this double-masked study involving 66 patients, the two aminoglycosides were found to be equally safe and effective, although the in vitro data suggested that tobramycin may be more efficacious against Pseudomonas infections. Staphylococcus aureus and S. epidermidis were the most frequent isolates from the infected eyes (59.8% and 20.6%, respectively).
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003229:Conjunctival Diseases / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011552:Pseudomonas Infections / Q000188:drug therapy; D013203:Staphylococcal Infections / Q000188:drug therapy; D014031:Tobramycin / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D014031:Tobramycin