[Experimental basis of a new principle for purifying antilymphocyte serum].
The experiment has demonstrated a higher immunosuppressive activity of antilymphocytic serum, purified with the use of a placental immunoadsorbent, in comparison with the preparations exhausted by red blood cells and plasma. This fact experimentally substantiates the use of the immunoadsorbent prepared from human placenta for the purification of antilymphocytic immunoglobin preparations. Rabbit immunoglobulin to human lymphocytes obtained by means of the new method corresponds to the technical specifications for such preparations and is less reactogenic than antilymphocytic immunoglobulin prepared in accordance with the routine technology.
D000818:Animals; D000961:Antilymphocyte Serum; D006084:Graft Rejection; D016027:Heart Transplantation; D006801:Humans; D006824:Hybridization, Genetic; D007164:Immunosorbents; D007166:Immunosuppressive Agents; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010920:Placenta / Q000276:immunology; D011817:Rabbits / Q000276:immunology; D016038:Skin Transplantation; D013601:T-Lymphocytes / Q000276:immunology*
D000961:Antilymphocyte Serum; D007164:Immunosorbents; D007166:Immunosuppressive Agents
Eksperimental'noe obosnovanie novogo printsipa ochistki antilimfotsitarnoĭ syvorotki.