Comparison of the antihypertensive effects of indapamide and metoprolol.
The effects on blood pressure and heart rate of 200 mg metoprolol and 2.5 mg indapamide given separately and together as a single daily dose were compared in 27 patients suffering from moderate hypertension. The blood pressure and heart rate were measured in the lying and standing position, before, during and after exercise. Both indapamide and metoprolol in a single daily dose reduced the blood pressure. The best results were achieved by a combination of the two.
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004232:Diuretics / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007190:Indapamide / Q000627:therapeutic use*; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use*; D008875:Middle Aged; D005082:Physical Exertion; D011412:Propanolamines / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D004232:Diuretics; D011412:Propanolamines; D007190:Indapamide; D008790:Metoprolol