Laboratory data on the experimental transmission of Creutzfeldt--Jakob disease in the guinea pig.
Cerebrospinal fluid samples collected from 3 patients with Creutzfeldt-Jakob disease were inoculated intracerebrally to guinea pigs. After an incubation period of 4-14 months the animals developed a serially transmissible disease, characterized by loss of appetite, loss of weight, difficulty in movement, myoclonic convulsions and a fatal outcome within several days. The microscopic lesions caused by the experimental disease consisted in glial proliferation, spongiform change and vacuolation of the cytoplasm of proximal dendritic regions.
D000818:Animals; D001921:Brain / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D007562:Creutzfeldt-Jakob Syndrome / Q000473:pathology / Q000635:transmission*; D003712:Dendrites / Q000473:pathology; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006801:Humans; D009457:Neuroglia / Q000473:pathology