Chlorpromazine and propranolol extend survival of infant mice inoculated with enterotoxigenic Escherichia coli.
Effects of chlorpromazine and propranolol were tested in infant mice model of Enterotoxigenic Escherichia coli diarrhea. Reference strain B41 inoculated orally from 18 h to 48 h after birth causes death of almost all animals in less than 48 h. Both drugs, which are known to reverse submaximal induced secretion by heat-stable toxin in the suckling mouse assay, used as single treatment, were able to extend the survival of mice.
D000284:Administration, Oral; D000818:Animals; D002746:Chlorpromazine / Q000008:administration & dosage / Q000627:therapeutic use*; D003967:Diarrhea / Q000188:drug therapy / Q000401:mortality; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000401:mortality; D007279:Injections, Subcutaneous; D051379:Mice; D008815:Mice, Inbred Strains; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use*
D011433:Propranolol; D002746:Chlorpromazine