title: [Results of chemotherapy with cyclophosphamide, vincristine, methotrexate and prednisone in recurring or disseminated non-Hodgkin lymphomas in the University of Kiel Radiology Clinic].
abstract: 91 patients with malignant non-Hodgkin-lymphoma are discussed, who received a reinduction therapy because of their state of relapse or dissemination. All of them received chemotherapy as a secondary treatment. The drugs were cyclophosphamide, vincristine, methotrexate, and prednisone. The result were separately analyzed for lymphomas with "high-grade malignancy" and lymphomas with "low-grade malignancy" using the "Kiel-Klassifikation". Within the group of low-grade lymphomas, there were 29% complete remission, 56% partial remission, and 15% without response. In the group of high-grade malignant lymphomas there were 39% complete remission, 37% partial remission, and 24% without response. The curves of disease-free survival are similar for both groups of malignant low-grade and high-grade lymphoma. The curve for survival, irrespective of exacerbation, takes a more favorable course for low-grade than for high-grade lymphomas but reaches a common plateau at 30%. After 2 1/3 years 50% of the patients with low-grade-malignant lymphoma, and after 1 1/2 year 50% of the patients with high-grade-malignant lymphoma, are still alive. The longest period of disease-free survival is now 8 years in some cases. We attempt to draw conclusions from the results of the therapy about the nature of malignant non-Hodgkin-lymphoma and to give suggestions for its treatment.
mesh_terms: D003520:Cyclophosphamide / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D008727:Methotrexate / Q000627:therapeutic use*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D009367:Neoplasm Staging; D011241:Prednisone / Q000627:therapeutic use*; D014750:Vincristine / Q000627:therapeutic use*
chemical_list: D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone; D008727:Methotrexate
vernacular_title: Ergebnisse einer Chemotherapie mit Cyclophosphamid, Vincristin, Methotrexat und Prednison bei rezidivierenden oder disseminierten Non-Hodgkin-Lymphomen in der Radiologischen Klinik der Universität Kiel.