title: Changes of the intralymphocytic sodium concentration after acute and chronic captopril administration.
abstract: The effect of captopril on intralymphocytic sodium concentration in hypertensive subjects was studied. After acute and chronic treatment the intralymphocytic sodium content decreased. The possibility is discussed that a similar decrease might also occur in smooth muscle cells, thus enhancing the hypotensive effect of captopril.
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D011392:Proline / Q000031:analogs & derivatives*; D012083:Renin / Q000097:blood; D012964:Sodium / Q000097:blood*
chemical_list: D000450:Aldosterone; D011392:Proline; D002216:Captopril; D012964:Sodium; D012083:Renin; D011188:Potassium