[Role of sex hormones in realizing the monoamine effect on the luliberin content in the hypothalamus].
Drastic decrease in the level of sex hormone in the blood of castrated male rats lessened the content of LH-RH in the arcuate nuclei and median eminence of the hypothalamus. Obviously, this area is the place affected by androgens within the system of the negative feedback mechanism. Intraventricular noradrenaline had a stimulating effect on the synthesis and secretion of LH-RH in both intact and castrated animals. Meanwhile in the absence of sex steroids that action was less powerful. Dopamine stimulated the release of LH-RH from the terminals of the median eminence in all the groups of the animals. In intact animals, serotonin had no effect on the content of LH-RH, while in the castrated animals, it produced an inhibitory action on the synthesis and secretion of LH-RH. The results indicate that the intensity and the line of the effects of monoamines under study may depend to a certain extent on the animals endocrine status. The effects of monoamines on LH-RH neurones is steroid-dependent.
D000818:Animals; D002369:Castration; D004298:Dopamine / Q000494:pharmacology*; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D007987:Gonadotropin-Releasing Hormone / Q000097:blood / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*
D012739:Gonadal Steroid Hormones; D012701:Serotonin; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D004298:Dopamine; D009638:Norepinephrine
Rol' polovykh gormonov v osushchestvlenii vliianiia monoaminov na soderzhanie liuliberina v gipotalamuse.