The effect of inorganic phosphate on the stability of some enzymes.
In the presence of 5nM-P1, 6-phosphogluconate dehydrogenase from the yeast Candida utilis is more resistant to proteolysis and to the inactivating action of some chemical and physical agents. P1 also protects other enzymes against proteolysis. A hypothesis for the mechanism of the stabilizing action of P1 is advanced.
D002175:Candida / Q000201:enzymology; D004355:Drug Stability; D010450:Endopeptidases / Q000494:pharmacology; D010088:Oxidoreductases / Q000037:antagonists & inhibitors; D010710:Phosphates / Q000494:pharmacology*; D010734:Phosphogluconate Dehydrogenase / Q000037:antagonists & inhibitors*; D013431:Sulfates / Q000494:pharmacology
D010710:Phosphates; D013431:Sulfates; D010088:Oxidoreductases; D010734:Phosphogluconate Dehydrogenase; D010450:Endopeptidases