An immunoperoxidase technique to aid in the differential diagnosis of prostatic carcinoma.
The unlabeled immunoperoxidase technique and antibody to human prostatic acid phosphatase was used to study a variety of normal and neoplastic tissues. The technique was found to be a useful adjunct in the differential diagnosis of prostatic carcinoma versus transitional cell carcinoma of the bladder and rectal adenocarcinoma, but was not entirely specific, as cross-reactivity with rectal carcinoid tumors was documented. This study emphasizes the importance of controlled testing of these antibodies by pathology laboratories using immunoperoxidase techniques to assure accurate surgical pathologic diagnosis.
D000135:Acid Phosphatase / Q000032:analysis*; D002277:Carcinoma / Q000175:diagnosis*; D004796:Clinical Enzyme Tests; D003937:Diagnosis, Differential; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D011471:Prostatic Neoplasms / Q000175:diagnosis*
D000135:Acid Phosphatase