[Therapeutic trial with allopurinol in progressive muscular dystrophy (author's transl)].
Authors present a therapeutic trial with allopurinol on Duchenne muscular dystrophy. On an initial stage of three months they compare the effect of this drug with a placebo, finding no significant results. Afterwards they compare at six weeks, three months and six months the effects on muscle power, chronometered physical exercise and values of CPK without obtaining significant results. The changes on urate serum, and relation urine urate/creatinine are significant at six weeks, three months and six months of treatment.
D000293:Adolescent; D000493:Allopurinol / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003402:Creatine Kinase / Q000097:blood; D004311:Double-Blind Method; D005080:Exercise Test; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009136:Muscular Dystrophies / Q000188:drug therapy* / Q000503:physiopathology / Q000652:urine; D014527:Uric Acid / Q000652:urine
D014527:Uric Acid; D000493:Allopurinol; D003402:Creatine Kinase
Ensayo terapéutico con alopurinol en la distrofia muscular progresiva tipo Duchenne.