title: The use of hyperbaric oxygen therapy in bony reconstruction of the irradiated and tissue-deficient patient.
abstract: Eighteen bony reconstructions of the mandible or maxilla using a newly defined and specific hyperbaric oxygen protocol are reported. Eleven of 12 grafts in irradiated tissue met six rigid criteria for a 91.6% rate of success. All six grafts into scarred and deficient tissue beds also met the same criteria, for an overall success rate of 94%. The rationale for emphasizing preoperative tissue preparation using hyperbaric oxygen is discussed, as are the mechanisms of action of hyperbaric oxygen on a biochemical, cellular, and tissue level. Neovascularity and neocellularity are demonstrated histologically by human biopsy specimens, and this is suggested as being the reason for the excellent results of reconstruction in irradiated and/or deficient tissue beds.
mesh_terms: D000328:Adult; D000368:Aged; D001861:Bone Regeneration; D016025:Bone Transplantation; D005260:Female; D006085:Graft Survival; D006801:Humans; D006931:Hyperbaric Oxygenation; D007568:Jaw / Q000293:injuries / Q000502:physiology; D007573:Jaw Neoplasms / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D008875:Middle Aged; D056948:Orthognathic Surgical Procedures; D013518:Surgery, Plastic / Q000379:methods; D014945:Wound Healing; D014948:Wounds, Gunshot / Q000601:surgery