Evidence that the arginine esteropeptidase (gamma) subunit of nerve growth factor can activate inactive renin.
The beta and gamma subunits of nerve growth factor were isolated and tested for inactive-renin-activating activity using human amniotic fluid as a convenient source of inactive renin. Only the gamma subunit, which is an arginine esteropeptidase, could activate inactive renin. The role of this enzyme in sites containing both it and inactive renin warrants investigation.
D000653:Amniotic Fluid / Q000201:enzymology; D000818:Animals; D002265:Carboxylic Ester Hydrolases; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D046911:Macromolecular Substances; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009414:Nerve Growth Factors / Q000378:metabolism*; D011247:Pregnancy; D012083:Renin / Q000378:metabolism*; D013363:Submandibular Gland
D046911:Macromolecular Substances; D009414:Nerve Growth Factors; C019724:arginine esterase; D002265:Carboxylic Ester Hydrolases; D012083:Renin