Metabolism of verruculogen in rats.
Radiolabeled verruculogen was detected in a wide range of body tissues 6 min after intravenous administration, but after a further 20 min it was mainly being excreted via the biliary route. In isolated liver perfusion, [14C]verruculogen was rapidly taken up by the liver and metabolized completely, principally to the related tremorgen TR-2 but also to a desoxy derivative of verruculogen. In addition, a smaller amount of an isomer of TR-2 was detected. These metabolic products were excreted in the bile.
D000818:Animals; D001646:Bile / Q000378:metabolism; D002250:Carbon Radioisotopes; D002851:Chromatography, High Pressure Liquid; D005260:Female; D007211:Indoles / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D009183:Mycotoxins / Q000378:metabolism*; D010477:Perfusion; D011865:Radioisotope Dilution Technique; D051381:Rats; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D007211:Indoles; D009183:Mycotoxins; C009658:verruculogen