title: The effect of ampicillin on skin graft survival and antibody response in B6A F1 mice.
abstract: The effect of ampicillin on the immune response to sheep red blood cells (SRBC) and on the survival of BALB/c skin allograft in B6A F1 mice was studied. At the non-toxic doses of 250-500 mg/kg per day, given repeatedly before or after injection of SRBC or skin grafting, there was a marked enhancement of the antibody response and a prolongation of skin graft survival from 12.7 +/- 0.23 days in untreated mice to 13.7 +/- 0.19 days and 15.2 +/- 0.75 days in mice treated before or after skin grafting, respectively.
mesh_terms: D000667:Ampicillin / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D012756:Sheep; D016038:Skin Transplantation; D013997:Time Factors
chemical_list: D000667:Ampicillin