Use of topical benzydamine in gynecology.
To evaluate the topical anti-inflammatory activity of benzydamine when used as 0.1% solution for vaginal douche, a double blind, parallel group, randomized clinical trial was carried out on 30 patients with vaginitis following internal radiotherapy for carcinoma of the uterus. The patients were divided into 3 groups, one being treated with 0.1% benzydamine plus tricetol as preservative, one with 0.1% benzydamine alone, and one with placebo. Treatment began 12-24 hours after radiotherapy. Benzydamine was found to be significantly superior to placebo in its overall topical anti-inflammatory activity both after 5 and 15 days of treatment. Tricetol did not interfere with the therapeutic effect of benzydamine.
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D001591:Benzydamine / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D011720:Pyrazoles / Q000008:administration & dosage*; D011897:Random Allocation; D007507:Therapeutic Irrigation; D014594:Uterine Neoplasms / Q000532:radiotherapy; D014627:Vaginitis / Q000188:drug therapy* / Q000209:etiology
D011720:Pyrazoles; D001591:Benzydamine