Structure-function relationships in insulin.
A new interpretation of structure-function relationships in the insulin molecule is presented. Negative cooperativity is postulated to arise from a dimerization event occurring between two receptor-bound molecules. The receptor-binding surface of insulin can necessarily not involve residues involved in dimerization as has been generally accepted. Support for this interpretation is based on published data.
D055598:Chemical Phenomena; D002621:Chemistry; D007328:Insulin / Q000031:analogs & derivatives / Q000378:metabolism*; D008956:Models, Chemical; D011972:Receptor, Insulin / Q000378:metabolism*; D013329:Structure-Activity Relationship
D007328:Insulin; D011972:Receptor, Insulin