[Effect of phenformin on fetal mass in rats previously immunized with an extract of homologous thyroid gland].
Rats immunized with homologous thyroid antigen 9-27 weeks before delivery manifest an increase in the mean weight of fetus as compared with normal pregnant rats. Administration of phenformin (7.5 mg/day per os) during immunization and over 30 days after its discontinuance led to a significant weight reduction as compared with immunized animals not given phenformin. The latter's effect became more potent with an increase in the interval between immunization discontinuance and delivery. Prophylaxis and cure of the latent and evident autoimmune lesions of the thyroid gland during childhood and juvenescence are regarded as approaches to the prevention of endocrine and metabolic disorders favouring large fetus delivery.
D000818:Animals; D001327:Autoimmune Diseases / Q000150:complications / Q000196:embryology*; D001724:Birth Weight / Q000187:drug effects*; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D005260:Female; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000473:pathology; D010629:Phenformin / Q000627:therapeutic use*; D011247:Pregnancy; D051381:Rats; D013961:Thyroid Gland / Q000276:immunology*; D013966:Thyroiditis / Q000150:complications
D001786:Blood Glucose; D007328:Insulin; D010629:Phenformin
Vliianie fenformina na massu plodov u krys, predvaritel'no immunizirovannykh ékstraktom tkani gomologichnoĭ shchitovidnoĭ zhelezy.