title: [Criteria of good metabolic control in children and adolescents with diabetes mellitus (author's transl)].
abstract: Treatment of insulin-dependent children and adolescents is aimed at normalizing the metabolism without harming the patient, and to avoid the development of secondary vascular and neural changes. On the other hand, however, therapy has to cope with limited possibilities to optimize insulin substitution and to achieve normal metabolic regulation. Therefore, criteria of "good" metabolic control differ, depending on whether they relate to a desirable or to an acceptable metabolic regulation. Actual therapeutical achievements rarely meet initial expectations. Paediatric diabetologists seem to fairly well agree on the criteria of an acceptable metabolic control of insulin-dependent children and adolescents, i.e. freedom of symptoms, normal growth and development, glucosuria of less than 20 g/d or of 5-10% of carbohydrate intake, and pre- and postprandial blood glucose levels of less than 150 and less than 200 mg/dl, respectively, in greater than or equal to 75% of the observation time. Concentrations of glycosylated haemoglobin (Hb A1) of less than 11% (total, microcolumn technique), and less than 10% (stable fraction) seem to fairly well correspond to the indicated blood glucose level of less than 200 mg/dl.
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002657:Child Development; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis* / Q000188:drug therapy; D006442:Glycated Hemoglobin / Q000032:analysis; D006029:Glycosuria / Q000175:diagnosis; D006128:Growth; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin
vernacular_title: Kriterien guter Diabeteseinstellung bei Kindern und Jugendlichen.