title: [Structure of the human spleen and immunomorphologic indices of its lymphocytes during embryogenesis].
abstract: The authors studied the development and differentiation of spleen lymphocytes and tissues from 100 human embryos aged 5-34 weeks. T-/E-RFC) and B lymphocytes (IgG plus G cells) were identified by histochemical and immunomorphological methods. The weight and quantitative values of the spleen and lymphocytes are presented. The development of the spleen consists of three periods: 1) an early one (5-8 weeks) when the organ is characterized by a compact arrangement of the mesenchymal cells; 2) 9-11 weeks, when blood deposition function prevails; 3) appearance of lymphopoiesis after 13-14 weeks. Heterogenicity of spleen lymphocytes and the time course of the quantitative changes during embryogenesis are reported. It is concluded that the humans spleen presents a polyfunctional organ even in the embryonal period.
mesh_terms: D002454:Cell Differentiation; D005455:Fluorescent Antibody Technique; D005865:Gestational Age; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D009929:Organ Size; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D013154:Spleen / Q000166:cytology / Q000196:embryology* / Q000276:immunology
chemical_list: D011947:Receptors, Antigen, B-Cell
vernacular_title: Struktura selezenki cheloveka i immunomorfologicheskie pokazateli ee limfotsitov v émbriogeneze.