Radiosensitization by non-nitro compounds.
The effects of 23 non-nitro compounds on the radiosensitivity of hypoxic Chinese hamster V79-379A or E. coli AB 1157 cells in vitro are outlined. Imidazole derivatives substituted with several alternative electron-withdrawing groups are described; the dicyanovinyl function conferred considerable radiosensitizing activity. 2,4,5-Tribromoimidazole and 2,4-dinitrophenol may show unusual radiosensitizing activity because of interference with oxidative phosphorylation. Attempts to influence radiosensitivity by compounds potentially capable of depleting intracellular sulphydryls are also described.
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004583:Electrons; D004926:Escherichia coli; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000378:metabolism; D014475:Uncoupling Agents
D011838:Radiation-Sensitizing Agents; D013438:Sulfhydryl Compounds; D014475:Uncoupling Agents