Adjuvant chemotherapy in Ewing's sarcoma patients.
At the Istituto Nazionale Tumori of Milan 60 patients with clinically localized Ewing's sarcoma were treated during 1965-1978 according to three different protocols. From 1965-1971, 18 patients received almost exclusively local therapy and 17 of 18 (94%) relapsed in a median time of 6 months. From 1971-1978 adjuvant chemotherapy according to two different drug schedules was employed after radiotherapy. Twenty-five of 42 (59%) are surviving and relapse-free at this time (follow-up 20-101 months).
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D012512:Sarcoma, Ewing / Q000188:drug therapy / Q000532:radiotherapy; D014750:Vincristine / Q000627:therapeutic use
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D008727:Methotrexate