title: In situ characterization of cell infiltrates in the dermis of human scabies.
abstract: Cell infiltrates in the dermis of biopsy specimens from skin lesions of seven patients with scabies were characterized by receptors for sheep erythrocytes (T-lymphocytes), Fc C3b (macrophages and B-lymphocytes) and C3d receptors (B-lymphocytes) using hemadsorption to cryostat sections in closed chamber. T-lymphocytes were also identified using an indirect immunofluorescence technique with rabbit anti-T-lymphocyte serum. All sections showed perivascular mononuclear cell infiltrates in the dermis as judged by sections stained by hematoxylin and eosin. T-lymphocytes were the predominant cells in the infiltrates. Fewer macrophages and very few B-lymphocytes were detected. Cell-mediated immune response may be of importance in the pathogenesis of scabies.
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006383:Hemadsorption Inhibition Tests; D006801:Humans; D008264:Macrophages / Q000276:immunology; D011817:Rabbits; D011951:Receptors, Complement / Q000276:immunology; D011961:Receptors, Fc / Q000276:immunology; D012397:Rosette Formation; D012532:Scabies / Q000276:immunology / Q000473:pathology*; D012756:Sheep; D012867:Skin / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D011951:Receptors, Complement; D011961:Receptors, Fc