title: L-Asparaginase: discovery and development as a tumor-inhibitory agent.
mesh_terms: D000818:Animals; D001215:Asparaginase / Q000266:history / Q000302:isolation & purification / Q000627:therapeutic use*; D001216:Asparagine / Q000378:metabolism; D002460:Cell Line; D004926:Escherichia coli / Q000201:enzymology; D006168:Guinea Pigs; D006207:Half-Life; D049673:History, 20th Century; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D012513:Sarcoma, Experimental / Q000378:metabolism
chemical_list: D001216:Asparagine; D001215:Asparaginase