[Activity and temperature dependence of acid peptidohydrolase in cerebral tissue of adrenalectomized rats under moderate hypothermia].
The activity of acid peptidohydrolase and its temperature dependence were determined in the cerebral cortex and totally in the midbrain and diencephalon of rats in normal state after a false operation and with bilateral adrenalectomy as well as under moderate (30 degrees C) hypothermia of intact, false-operated and adrenalectomized animals. The enzyme activity is established to change more significantly in the cerebral cortex. Adrenalectomy lowers it in the cortex at an incubation temperature of 30 and 20 degrees C. Incubation at a temperature of 37, 25, 20 and 15 degrees C decreases this activity under animal cooling as well. A combined effect of hypothermia and adrenalectomy on the enzyme activity is not additive.
D000315:Adrenalectomy; D000818:Animals; D016282:Aspartic Acid Endopeptidases; D001921:Brain / Q000201:enzymology*; D002540:Cerebral Cortex / Q000201:enzymology; D004027:Diencephalon / Q000201:enzymology; D010450:Endopeptidases / Q000378:metabolism*; D007035:Hypothermia / Q000201:enzymology*; D007700:Kinetics; D008297:Male; D008636:Mesencephalon / Q000201:enzymology; D051381:Rats; D013696:Temperature
D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases
Aktivnost' i temperaturnaia zavisimost' kisloĭ peptidgidrolazy v tkani mozga adrenaléktomirovannykh krys pri umerennoĭ gipotermii.