The effect of staphylococcal delta-haemolysin on the secretory activity of the pancreatic beta-cell.
The secretion of insulin from isolated rat islets of Langerhans was found to be stimulated by the surface-active staphylococcal exotoxin, delta-haemolysin. The response was dependent on the concentration of delta-haemolysin, was rapid in onset, and could be maintained for at least an hour in the presence of the agent. The rate of secretion rapidly declined on removal of delta-haemolysin and the islets remained responsive to glucose following toxin treatment. Further characterization of the interaction of this agent with the beta-cell plasma membrane may provide valuable information concerning the role played by this membrane in the regulation of insulin secretion.
D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D007700:Kinetics; D051381:Rats
D001427:Bacterial Toxins; D007328:Insulin; C025971:staphylococcal delta toxin; D005947:Glucose