The T-dependent and T-independent humoral immune response in cobra venom treated mice.
The humoral immune response to T-dependent antigens (SRBC, DNP5BSA, DNP50BSA, DNP-KLH) and T-independent antigens (SIII, Levan, DNP-SIII, DNP-Levan) was studied by hemolytic plaque assay in mice depleted of C3 by Cobra venom treatment. Suppression of the immune response in C3 depleted animals was not restricted only to T-dependent response and also the response to some T-dependent antigens (DNP50-BSA, DNP-KLH) was not suppressed under conditions of the experiment. Results are discussed in relation to postulated exclusive role of C3 in the induction of T-dependent immune response.
D000818:Animals; D002478:Cells, Cultured; D003169:Complement Inactivator Proteins; D004546:Elapid Venoms / Q000494:pharmacology*; D005260:Female; D006462:Hemolytic Plaque Technique; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D007166:Immunosuppressive Agents; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D003169:Complement Inactivator Proteins; D004546:Elapid Venoms; D000949:Histocompatibility Antigens Class II; D007166:Immunosuppressive Agents