title: Induction of hepatic malic enzyme in response to insulin.
abstract: The activity and quantity of hepatic malic enzyme were determined in diabetic rats at various times after insulin treatment. The increase in activity observed following insulin treatment was accompanied by a similar increase in the quantity of this enzyme, as determined by a specific radioimmunoassay. These results demonstrate that the insulin-mediated increase in malic enzyme activity was due to an increase in the quantity of enzyme and did not involve a modification of existing enzyme molecules.
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000201:enzymology; D004790:Enzyme Induction / Q000187:drug effects; D007328:Insulin / Q000494:pharmacology* / Q000627:therapeutic use; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008291:Malate Dehydrogenase / Q000096:biosynthesis*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007328:Insulin; D008291:Malate Dehydrogenase