title: A clinical trial of oral cholecystography using combinations of contrast agents and two consecutive doses.
abstract: Fifteen healthy volunteers underwent a randomized trial of oral cholecystography (OCG) using 5 different combinations of contrast agents given as 2 consecutive doses: Telepaque (iopanoic acid) given with food (TF) or without food (T), Bilopaque (sodium tyropanoate) given without food, and a combination of both agents (TF-B). The density of gallbladder opacification was judged visually on a scale of 1+ to 4+ and quantitatively by a densitometric method. Comparison of gallbladder opacification on the first and second days of the study revealed 52 of 75 (70%) combinations (TF-T, TF-TF,T-T, TF-B, B-B) resulted in improved opacification, 17% in equal opacification, and 13% in worse opacification on day 2. The TF-B combination showed the highest number (9) of excellent (grade 4+) results and the lowest number (2) of poor (grade 1+ and 2+) results, gave the best opacification in 8 volunteers, and had the highest average density difference (0.32) between first- and second-day opacifications. The TF-TF combination was the next most effective, and the T-T combination was the least effective. The results indicate that OCG in 2 consecutive doses is superior to single-dose OCG, and that a combination of TF-B or TF-TF will provide the greatest gallbladder opacification. The TF-B combination is recommended because of better patient tolerance.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002765:Cholecystography / Q000379:methods*; D002986:Clinical Trials as Topic; D003287:Contrast Media / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005215:Fasting; D005260:Female; D005502:Food; D006801:Humans; D007480:Iopanoic Acid / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D014441:Tyropanoate / Q000008:administration & dosage
chemical_list: D003287:Contrast Media; D014441:Tyropanoate; D007480:Iopanoic Acid