[Summary insulin-like activity of the blood serum in breast cancer and in specific age-related pathology].
Total insulin-like activity (ILA) was evaluated by biological testing blood serum on the basis of stimulation of glycogen synthesis in rat diaphragm in vivo. Glucose loading was followed by an increase in ILA and radioimmune insulin (RII) levels both in patients with breast fibroadenomatosis and healthy controls. However, the patients revealed an increased RII response matched by absence of ILA response, while the basal ILA was three times that in healthy controls. An elevated basal level of ILA was also observed in patients with coronary atherosclerosis and mental depression. Enhanced hyperinsulinism due to RII complementary factors, capable of insulin-like activity, may prove to be a factor in specific age-associated pathology (cancer, atherosclerosis, mental depression).
D000232:Adenofibroma / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000375:Aging; D001786:Blood Glucose / Q000032:analysis; D001943:Breast Neoplasms / Q000097:blood*; D002648:Child; D003327:Coronary Disease / Q000097:blood*; D003866:Depressive Disorder / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids
Summarnaia insulinopodobnaia aktivnost' syvorotki krovi u bol'nykh rakom molochnoĭ zhelezy i pri spetsificheskoĭ vozrastnoĭ patologii.