title: Preoperative intraparietal (intra-incisional) cefoxitin in abdominal surgery.
abstract: The effect of preoperative intraparietal (intra-incisional) injection of cefoxitin along the site of the intended incision on the incidence of wound infection has been investigated by a randomized prospective study of 181 consecutive patients undergoing abdominal surgery. A significant reduction in wound infection was evident in the cefoxitin-treated group (4.4 per cent) when compared with controls (16.7 per cent) (chi 2 = 6; P = 0.02). Administration of antibiotic by this route did not delay wound healing or produce any undesirable sequelae.
mesh_terms: D000005:Abdomen / Q000601:surgery; D000328:Adult; D000368:Aged; D002440:Cefoxitin / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D013530:Surgical Wound Infection / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D002440:Cefoxitin