Histopathological and laboratory assessment of visual dysfunction.
The currently available methods of assessing ocular toxicity are discussed. Manifestations of ocular toxicity are best described clinically; histopathological examination of the eye is beset with problems of preparing the eye for morphological examinations. Electron microscopy is essential to look for chemically induced side effects at the cellular level. Mechanisms of ocular toxicity are poorly understood, and the limitation of animal studies in predicting side effects in man must be appreciated.
D000818:Animals; D003316:Corneal Diseases / Q000139:chemically induced; D005128:Eye Diseases / Q000139:chemically induced; D006801:Humans; D007908:Lens, Crystalline / Q000187:drug effects; D009901:Optic Nerve Diseases / Q000139:chemically induced; D012164:Retinal Diseases / Q000139:chemically induced; D014603:Uveal Diseases / Q000139:chemically induced; D014786:Vision Disorders / Q000473:pathology / Q000503:physiopathology*; D014787:Vision Tests / Q000379:methods*