An oocyte-specific antigen and its possible role in the organization of the ovarian follicle of the rat.
An oocyte-specific antigen was detected by an antiserum produced in isogenic Lewis rats. The antigen was sensitive to trypsin treatment. Dissociation-reorganization experiments in vitro, using ovarian cells demonstrated that the antigen is required for the interaction of germ cells and somatic cells. A physiologic role is suggested for this differentiation antigen in follicular morphogenesis and ovarian function.
D000818:Animals; D000941:Antigens / Q000032:analysis*; D005260:Female; D005455:Fluorescent Antibody Technique; D008297:Male; D051379:Mice; D009865:Oocytes / Q000166:cytology / Q000276:immunology* / Q000502:physiology; D009928:Organ Specificity; D006080:Ovarian Follicle / Q000166:cytology / Q000502:physiology*; D010063:Ovum / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew
D000941:Antigens