title: Effect of subminimal inhibitory concentrations of penicillin on hyaluronidase production by group A streptococci.
abstract: A sensitive dye-binding assay was employed to study the extracellular hyaluronidase produced by three penicillin-sensitive strains of group A streptococci belonging to M types 4, 24 and 28. Enzyme was produced by all strains at appreciable levels. Subminimal inhibitory concentrations of penicillin in growing cultures increased enzyme production by M types 4 and 24 strains. Growth of the M type 28 R strain with added antibiotic was accompanied by a reduced production of hyaluronidase.
mesh_terms: D004305:Dose-Response Relationship, Drug; D006821:Hyaluronoglucosaminidase / Q000096:biosynthesis*; D010400:Penicillin G / Q000494:pharmacology*; D013297:Streptococcus pyogenes / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development
chemical_list: D006821:Hyaluronoglucosaminidase; D010400:Penicillin G