title: On the uptake of nystatin by Saccharomyces cerevisiae. 1 Basic considerations.
abstract: The uptake of nystatin by sensitive Saccharomyces cerevisiae cells has been studied as a function of temperature and nystatin concentration. Following analysis of the data, kinetic rate constants and a monolayer capacity are calculated. This shows that c 13 X more nystatin is taken up than can be supported by the cell surface. The process is accompanied by an activation energy of 41.6 kJ mol-1. It is suggested that these data support a rapid uptake process onto the cell wall followed by a slower diffusion process through the wall to the membrane.
mesh_terms: D000327:Adsorption; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D002473:Cell Wall / Q000378:metabolism; D004058:Diffusion; D007700:Kinetics; D009761:Nystatin / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D013696:Temperature
chemical_list: D009761:Nystatin