Ontogenetic aspects of immune-complex trapping in the spleen and popliteal lymph nodes of the rat.
An ontogenetic approach was used to obtain information about the relation between structure and function of lymphoid tissues. In particular the development of the capacity to trap immune complexes was studied in relation to the development of the lymphoid compartments. For this purpose isologous horseradish (HRP)-ant-HRP complexes were injected into neonatal rats, and their fate was studied in the spleen and popliteal lymph nodes. Immune-complex trapping occurred as soon as primary follicles could be recognized; without follicles no trapping was observed. Several explanations for this simultaneous development of trapping capacity and follicular structure are discussed.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D008198:Lymph Nodes / Q000254:growth & development* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000254:growth & development* / Q000378:metabolism; D013997:Time Factors
D000936:Antigen-Antibody Complex