[Effect of propranolol on diuretic activity of furosemide hypertensive patients (author's transl)].
The effect of propranolol on water and sodium depletion provoked by frusemide was studied. Nine hypertensive patients were treated at 2-day intervals with a single dose of 40 mg of frusemide associated with a placebo or propranolol (320 mg given in 8 doses over a period of 24 hours). The association frusemide-propranolol is more hypotensive than frusemide alone. Propranolol reduced the rise in plasma renin activity and aldosteronuria provoked by the diuretic; total sodium output/24 h remained stable but sodium elimination was increased in the later samples. This prolongation of the natriuretic action is correlated with the inhibition of hyperaldosteronuria. Propranolol depresses urinary osmolality for a longer period than frusemide alone and water elimination tends to be higher. This action of the beta-blocker on urine concentration is independent of its effects on aldosteronuria but is correlated with the inhibition of the rise in plasma renin activity.
D000450:Aldosterone / Q000652:urine; D004231:Diuresis / Q000187:drug effects*; D004357:Drug Synergism; D005260:Female; D005665:Furosemide / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D009994:Osmolar Concentration; D011433:Propranolol / Q000627:therapeutic use*; D012083:Renin / Q000097:blood; D012964:Sodium / Q000652:urine
D000450:Aldosterone; D005665:Furosemide; D012964:Sodium; D011433:Propranolol; D012083:Renin
Effets du propranolol sur l'action diurétique du furosśmide chez l'hypertendu.