[Effects of trimethadione on the therapeutic efficiency of atropine and obidoxime in mice poisoned with various phosphoorganic compounds].
This paper was aimed at the observation of trimethadione therapeutic effects while this preparation was used as an agent supplementing the standard therapeutic mixture (cholinolytic and reactivator) for mice poisoning with phospholine--a compound of AO 217 and DEP. The studies covered 216 female mice of Balb C strain, body weight 18-24 g. After the determination of toxic doses of phosphoroorganic preparations administered subcutaneously, therapeutic effects of a mixture of atropine sulphate (10 mg/kg i.p.) and obidoxime (40 mg/kg i.p.) administered immediately after poisoning, were observed. Then trimethadione 300 mg/kg i.p. was of in a dose of 300 mg/kg i.p was added and the effects of that agent on the efficiency of basic medicines were observed. The studies were performed during 2 and 24 hr of observation. The observations prove that the efficiency of the basic therapeutic mixture during 24 hrs of observation of mice poisonings with AO 217 and DFP was respectively: 2.31 x and 2.64 x. In phospholine poisonings no increase in therapeutic effects were found.
D000818:Animals; D001285:Atropine / Q000627:therapeutic use*; D001812:Blood-Brain Barrier / Q000187:drug effects; D004357:Drug Synergism; D005260:Female; D007928:Lethal Dose 50; D051379:Mice; D008807:Mice, Inbred BALB C; D009768:Obidoxime Chloride / Q000627:therapeutic use*; D062025:Organophosphate Poisoning; D010080:Oxazoles / Q000494:pharmacology*; D010091:Oximes / Q000627:therapeutic use*; D014293:Trimethadione / Q000494:pharmacology*
D010080:Oxazoles; D010091:Oximes; D009768:Obidoxime Chloride; D001285:Atropine; D014293:Trimethadione
Wpływ trimetadionu na skuteczność lecznicza atropiny i obidoksymu w zatruciach myszy niektórymi zwiazkami fosforoorganicznymi.