Insulinotropic action of L-rhamnose in isolated rat islets.
L-Rhamnose at different concentrations stimulated incorporation of 3H-leucine both into islet (pro)insulin and that released into the medium. Maximum isotope incorporation with either glucose or rhamnose was seen at a concentration of 16.7 mM, although the glucose-induced effect was significantly greater. Like glucose, rhamnose also enhance the activities of acid phosphatase and cathepsin B in isolated rat islets.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002401:Cathepsin B; D002403:Cathepsins / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000096:biosynthesis*; D007515:Islets of Langerhans / Q000187:drug effects* / Q000201:enzymology; D007930:Leucine / Q000378:metabolism; D008297:Male; D011384:Proinsulin / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012210:Rhamnose / Q000494:pharmacology*
D007328:Insulin; D011384:Proinsulin; D000135:Acid Phosphatase; D002403:Cathepsins; D002401:Cathepsin B; D007930:Leucine; D005947:Glucose; D012210:Rhamnose