Acetohydroxy acid synthase is a target for leucine containing peptide toxicity in Escherichia coli.
Acetohydroxy acid synthase from a mutant resistant to leucine-containing peptides was insensitive to leucine inhibition. It is concluded that acetohydroxy acid synthase is a target for the toxicity of the high concentrations of leucine brought into Escherichia coli K-12 by leucine-containing peptides.
D000095:Acetolactate Synthase / Q000037:antagonists & inhibitors*; D004151:Dipeptides / Q000378:metabolism / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology*; D007930:Leucine / Q000494:pharmacology*; D007652:Oxo-Acid-Lyases / Q000037:antagonists & inhibitors*
D004151:Dipeptides; C033517:phenylalanylleucine; C015905:glycylleucine; D000095:Acetolactate Synthase; D007652:Oxo-Acid-Lyases; D007930:Leucine