Relationship of hypothyroidism to diabetes mellitus, renal amyloidosis, and thrombosis in purebred beagles.
Review of 484 records for colony Beagles revealed an association between hypothyroidism and diabetes mellitus. The average time between first notation of hypothyroidism and later development of diabetes mellitus was 2.8 years. An association was also made with hypothyroidism, renal amyloidosis, and thrombosis. Hypothyroidism was significantly related to thrombosis, thrombosis was significantly related to renal amyloidosis, but hypothyroidism and renal amyloidosis were not significantly related. Of 62 hypothyroid dogs, 11 were diabetic and 7 others had thrombosis. Six hypothyroid dogs had renal amyloidosis, 4 of which had thrombosis. One dog had renal amyloidosis and thrombosis in the absence of hypothyroidism. There does not appear to be an association with any of the lesions and previous low-dose, whole-body gamma, or sham irradiation.
D000686:Amyloidosis / Q000209:etiology / Q000662:veterinary*; D000818:Animals; D003920:Diabetes Mellitus / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000150:complications* / Q000209:etiology / Q000473:pathology; D004285:Dogs; D005260:Female; D007037:Hypothyroidism / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D007515:Islets of Langerhans / Q000473:pathology; D007674:Kidney Diseases / Q000209:etiology / Q000662:veterinary*; D008297:Male; D010902:Pituitary Gland / Q000473:pathology; D013924:Thrombophlebitis / Q000209:etiology / Q000662:veterinary*