In vitro motility of cells from human epidermoid carcinomas. A study by phase-contrast and reflection-contrast cinematography.
The motile behavior of six cell lines derived from human squamous carcinomas (two from the larynx, four from the tongue) was studied by cinematography under phase- and reflection-contrast illumination. The recorded cell activities consist in spreading, stationary and translocation motility, and aggregate formation. Within this common pattern, quantitative modifications ("sub-pattern") are stable properties of the individual cells lines. Such modifications are particularly evident with regard to the dynamic texture of the aggregates which ranges from loose, netlike structures to compact islands with smooth borders. Accordingly, the intensity of cell traffic within and around the aggregates varies considerably. It is discussed to what extent the in vitro motility of the carcinoma cell populations reflects their behavior in the organism and thus the significance of cell movements for invasion.
D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002460:Cell Line; D002465:Cell Movement; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008843:Microfilming / Q000379:methods; D008858:Microscopy, Phase-Contrast; D009361:Neoplasm Invasiveness; D010781:Photography / Q000379:methods; D014062:Tongue Neoplasms / Q000473:pathology*