title: [Polyresistance of asiatic P. falciparum to chloroquine and pyrimethamine-sulfadoxine combination. Apropos of a new case].
abstract: The authors report a case of a multi-drug resistant Asiatic P. falciparum strain in a first non-immune man treated out of an endemic zone after failure of chemoprophylaxis by pyrimethamine-sulfadoxine. The authors compare this care with the lately published cases in Germany and Switzerland. They call again that I and II resistances were observed at the time of the drug's trials in and out of endemic zones. They ascertain that this resistances are often associated with chloroquino-resistance and that their number increases chiefly in certain areas.
mesh_terms: D000328:Adult; D002160:Cambodia; D002738:Chloroquine / Q000494:pharmacology*; D004338:Drug Combinations; D004352:Drug Resistance, Microbial; D005602:France / Q000208:ethnology; D006801:Humans; D008288:Malaria / Q000517:prevention & control; D008297:Male; D010963:Plasmodium falciparum / Q000187:drug effects*; D011739:Pyrimethamine / Q000494:pharmacology*; D013413:Sulfadoxine / Q000494:pharmacology*; D013424:Sulfanilamides / Q000494:pharmacology*; D013785:Thailand
chemical_list: D004338:Drug Combinations; D013424:Sulfanilamides; D013413:Sulfadoxine; D002738:Chloroquine; D011739:Pyrimethamine
vernacular_title: Polyrésistance des P. falciparum asiatiques à la chloroquine et à l'association pyriméthamine-sulfadoxine. A propos d'un nouveau cas.