Lipid synthesis and storage by histiocytes X. Study "in vitro" for eosinophilic granuloma.
Using 14C glycerol and 3H glycerol, in a study of lipid metabolism of two cases of eosinophilic granuloma of the bone, the authors point out that this precursor is preferentially but not electively incorporated by mononuclear cells. This fixation particularly concerns the big cells with numerous lipid droplets and few X bodies. The precursor is essentially involved in neutral lipid synthesis. As is the case with common macrophages, this lipid synthesis might express various states of cellular maturation and ageing.
D002250:Carbon Radioisotopes; D004803:Eosinophilic Granuloma / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005333:Fetus; D005347:Fibroblasts / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism; D006646:Histiocytosis, Langerhans-Cell / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000096:biosynthesis; D008168:Lung / Q000378:metabolism; D010743:Phospholipids / Q000096:biosynthesis; D011247:Pregnancy; D014316:Tritium
D002250:Carbon Radioisotopes; D008055:Lipids; D010743:Phospholipids; D014316:Tritium; D005990:Glycerol