Calmodulin pharmacology.
Calmodulin (CaM) is a major intracellular receptor for Ca2+. CaM is thus a crucial receptor to consider in pharmacological modification of cellular activity. Potential mechanisms by which drugs may modify CaM effectiveness are considered in the context of its interaction with Ca2+ and in turn with its various effectors. Some examples of established drug mechanisms are considered. A wide range of chemical compounds representing diverse pharmacological classes are anti-CaM under some conditions. No simple relationships have been established between molecular level events and therapeutic applicability of anti-CaM compounds.
D002118:Calcium / Q000037:antagonists & inhibitors / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000037:antagonists & inhibitors*; D002147:Calmodulin / Q000032:analysis / Q000037:antagonists & inhibitors* / Q000502:physiology; D002148:Calmodulin-Binding Proteins; D002352:Carrier Proteins / Q000378:metabolism; D006801:Humans; D011619:Psychotropic Drugs / Q000378:metabolism; D011955:Receptors, Drug / Q000187:drug effects
D002135:Calcium-Binding Proteins; D002147:Calmodulin; D002148:Calmodulin-Binding Proteins; D002352:Carrier Proteins; D011619:Psychotropic Drugs; D011955:Receptors, Drug; D002118:Calcium