title: [Characteristics of the reaction of the embryonic hepatocyte to the effect of insulin and adrenaline].
abstract: Adrenaline (10-6 g/ml) and insulin (10-6-8 IE/ml) cause changes of the acid DNase and phosphatase activity in hepatic cells of rat embryos on the 20th day of development. Adrenaline stimulates granular endoplasmatic reticulum development, increases the number and size of lysosomes, breaks their integrity. Insulin practically has no effect on the DNase activity, but labilizes the lysosome membrane.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D003851:Deoxyribonucleases / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006651:Histocytochemistry; D007328:Insulin / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000196:embryology* / Q000201:enzymology; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D008854:Microscopy, Electron; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007328:Insulin; D003851:Deoxyribonucleases; D000135:Acid Phosphatase; D004837:Epinephrine
vernacular_title: Osobennosti reaktsii émbrional'nogo gepatotsita na deĭstvie insulina i adrenalina.