title: Evidence for major histocompatibility complex restriction in transplantation immunity.
abstract: Studies on the survival of histocompatibility-Y antigen (H-Y)-incompatible and skin-specific antigen (Skn)-incompatible skin grafts in mice, as well as those concerned with the survival of cultured parathyroid allografts in rats, indicate that grafts provoke a strong immune response only if they include donor macrophages (or Langerhans cells) or if major histocompatibility complex-compatible macrophages are available to react with cells bearing the foreign antigens.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D005260:Female; D007108:Immune Tolerance; D017710:Lymphocyte Transfusion; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D016038:Skin Transplantation; D014181:Transplantation Immunology; D014184:Transplantation, Homologous