Effect of antihypertensive drugs on plasma renin activity and urinary excretion of prostaglandin E2.
Urinary prostaglandin (PGE2) and plasma renin activity (PRA) were determined in 3 groups of hypertensive patients before and following 5 days of treatment with different antihypertensive drugs. In all 3 groups studied a substantial decrease of blood pressure was noted following treatment. However, whereas administration of chlorthalidone and hydralazine initiated a significant rise of PGE2 and PRA excretion, treatment with propranolol was associated with a decrease of these two parameters. In view of these findings it seems therefore as if renal production of PGE2 (at least with regard to propranolol, a beta-blocking agent), is not related to the hypotensive effect of the drug.
D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002752:Chlorthalidone / Q000627:therapeutic use; D015232:Dinoprostone; D005260:Female; D006801:Humans; D006830:Hydralazine / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use; D011458:Prostaglandins E / Q000652:urine*; D012083:Renin / Q000097:blood*
D000959:Antihypertensive Agents; D011458:Prostaglandins E; D006830:Hydralazine; D011433:Propranolol; D012083:Renin; D015232:Dinoprostone; D002752:Chlorthalidone