Modulation of rat testicular alcohol dehydrogenase by psychoactive agents.
The in vivo and in vitro effect of selected psychoactive agents on specific activity of rat testicular alcohol dehydrogenase (T-ADH) was studied. Drinking of 15% ethanol solution for 14 consecutive days inhibited endogenous T-ADH from controls. This inhibition was enhanced when the animals were kept in complete darkness. Short-term administration of drugs with various pharmacologic properties, i.e. CNS-stimulants, a muscle relaxant, an antidepressant and estrogenic steroids, exerted little effect on T-ADH. d-Amphetamine, 3-methoxytyramine (3MT) and histamine inhibited-T-ADH in vitro. The amphetamine inhibition was non-competitive and the KI50 determined was of moderate magnitude.
D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000818:Animals; D003624:Darkness; D004347:Drug Interactions; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D008297:Male; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000201:enzymology*
D011619:Psychotropic Drugs; D000429:Alcohol Oxidoreductases