Mutagenicity of some indoles and related compounds in the Ames test.
A series of indole derivatives and some analogues were tested for mutagenic activity using a histidine-requiring mutant of Salmonella typhimurium (TA 98). Quantitative tests were performed with and without addition of a liver fraction (S-9) from rats induced with Aroclor 1254. Three compounds, 2,3-dimethylindole, 2,3,5-trimethylindole and 2,3,6-trimethylindole, showed a mutagenic effect which was not increased on metabolic activation. The influence on the mutagenic activity of the number and positions of the substituents attached to the indole skeleton is discussed.
D000818:Animals; D007211:Indoles / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics; D013329:Structure-Activity Relationship
D007211:Indoles; D009153:Mutagens