title: [Effect of inhibition of intestinal glucosidase on protein and energy balance in rats].
abstract: In a two-factorial balance trial two dietary protein levels of 12 and 15% the effect of a supplement of 50 mg alpha-glucosidase inhibitor (Bay g 5421) per kilogram food on nutrient digestibility, protein, and energy balance was tested in growing rats. At both protein levels the alpha-glucosidase inhibitor reduced the apparent digestibility of protein by maximal 8 and 4%, those of starch and energy only by 3 and 1%, respectively. With the low protein supply the protein and energy retention was decreased each by 13% when the inhibitor was given. On the basis of metabolizable energy, 6 and 19% less energy in form of protein and fat, respectively, have been deposited compared with the control group. These results may indicate also an effect of the glucosidase inhibitor on the intermediary metabolism.
mesh_terms: D020909:Acarbose; D000818:Animals; D004044:Dietary Proteins / Q000008:administration & dosage; D004734:Energy Metabolism / Q000187:drug effects*; D005959:Glucosidases / Q000037:antagonists & inhibitors*; D065089:Glycoside Hydrolase Inhibitors; D007422:Intestines / Q000201:enzymology*; D008297:Male; D009844:Oligosaccharides / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014312:Trisaccharides / Q000494:pharmacology*
chemical_list: D004044:Dietary Proteins; D065089:Glycoside Hydrolase Inhibitors; D009844:Oligosaccharides; D011506:Proteins; D014312:Trisaccharides; D005959:Glucosidases; D020909:Acarbose
vernacular_title: Einfluss einer intestinalen Glukosidasenhemmung auf die Eiweiss- und Energiebilanz von Ratten.