[Immunodepressive action of anthracycline antibiotics studied on 2 different transplantation immunity models].
The effect of carminomycin and rubomycin in equitoxic doses on the reaction of rejection of the allogenic skin graft and the reaction of the transplant to the host in mice (RTAH) was studied. Carminomycin significantly hampered the rejection of the skin graft and under certain conditions prevented development of the RTAH which indicated suppression of the formation of the clone of the immune T-killers. Rubomycin almost did not hamper the rejection of the skin graft and had no effect on the RTAH which indicated the absence of the selective effect on the system of K-killers. Carminomycin eliminated the RTAH only when it was administered to the recipients of the allogenic lymphoid cells 24 hours after implantation of the cells to the mice treated with cyclophosphamide. When carminomycin was administered to the donors of lymphoid cells 24 hours before the beginning of the experiment, it did not suppress the ability of the cells from these donors to induce the RTAH. Therefore, its effect was directed to the precursors of T-killers activated in the host of the allogenic recipient.
D000818:Animals; D002360:Carubicin / Q000276:immunology*; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000276:immunology*; D006084:Graft Rejection / Q000187:drug effects; D006087:Graft vs Host Reaction / Q000187:drug effects; D007108:Immune Tolerance / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008954:Models, Biological; D016038:Skin Transplantation; D014181:Transplantation Immunology / Q000187:drug effects*; D014184:Transplantation, Homologous
D002360:Carubicin; D003630:Daunorubicin
Issledovanie immunodepressivnogo deĭstviia antratsiklinovykh antibiotikov na dvukh razlichnykh modeliakh transplantatsionnogo immuniteta.