title: Absence of lymphocyte glucocorticoid hypersensitivity in primary open angle glaucoma.
abstract: The glucocorticosteroid sensitivity of patients with primary open angle glaucoma and normal patients was determined by the quantity of dexamethasone required to reduce concanavalin A-induced lymphocyte blast transformation to 50% of control values (I50). This was performed under culturing conditions employing both serum-free medium and medium supplemented with 10% autologous serum. A comparison of the I50 between normal subjects and those with primary open angle glaucoma did not show a significant difference in steroid sensitivity under either of the two culturing conditions. It is concluded that persons with primary open angle glaucoma do not have a generalized inherited or acquired cellular hypersensitivity to glucocorticoids.
mesh_terms: D000328:Adult; D000368:Aged; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D005901:Glaucoma / Q000235:genetics / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics / Q000276:immunology*; D007158:Immunologic Techniques; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged
chemical_list: D003907:Dexamethasone