title: Circulating C peptide: measurement and clinical application.
abstract: Pancreatic beta-cell function is usually assessed by the measurement of plasma insulin concentration in various clinical situations. However, the advent of an assay for the measurement of connecting-peptide (C-peptide) concentration in plasma has provided a further method for the assessment of the secretory capacity of the pancreatic beta cell in clinical disorders, particularly in the investigation of hypoglycaemia. The metabolism and immunoassay methodology of C-peptide are reviewed, and its application in clinical practice is outlined.
mesh_terms: D002096:C-Peptide / Q000097:blood*; D004355:Drug Stability; D005934:Glucagon; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000502:physiology; D010455:Peptides / Q000097:blood*; D011863:Radioimmunoassay / Q000379:methods
chemical_list: D002096:C-Peptide; D007328:Insulin; D010455:Peptides; D005934:Glucagon