title: Clinical evaluation of domperidone in the treatment of chronic postprandial idiopathic upper gastrointestinal distress.
abstract: Eleven patients with symptoms of chronic postprandial idiopathic upper gastrointestinal distress served as their own controls in a clinical trial of a new prokinetic agent, domperidone. After evaluations to eliminate the presence of anatomic lesions, each subject was given domperidone and placebo in random order for one month. Using a symptom-scoring questionnaire, no superiority of domperidone over placebo could be demonstrated in the group as a whole. Improvement in two out of three patients with diabetic gastroparesis, however, was noted. Side-effects possibly related to domperidone consisted of gas pains and skin rash in one patient each.
mesh_terms: D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004294:Domperidone / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004435:Eating; D004890:Erythema / Q000139:chemically induced; D005767:Gastrointestinal Diseases / Q000188:drug therapy*; D006801:Humans; D010146:Pain / Q000209:etiology
chemical_list: D004294:Domperidone