The effect of oral contraceptives on reproductive function during semichronic exposure to ethanol by the female rat.
1. Female rats were placed on water, 5% ethanol (ET), or 20% ET drinking solutions for 8 weeks. The last 2 weeks, the rats received orally either ethinyl estradiol (EE), norethindrone acetete (NED), or a combination of both. 2. Luteinizing hormone decreased due to ET drinking and was undetectable subsequent to the steroidal treatment. 3. Prolactin increased after steroid treatment and alcohol drinking in the controls. 4. Ethanol (5%) plus EE increased prolactin as did the steroidal combination, whereas ET (20%) likewise increased prolactin in conjunction with NED over water controls. 5. Hepatic alcohol dehydrogenase was inhibited due to EE when compared to water-controls in the 5% ET drinking animal, whereas aldehyde dehydrogenase was induced in combination with NED in both the 5% and 20% ET drinking rats.
D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D009640:Norethindrone / Q000494:pharmacology; D011247:Pregnancy; D011388:Prolactin / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects*; D014621:Vagina / Q000166:cytology
D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D004997:Ethinyl Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D000429:Alcohol Oxidoreductases; D009640:Norethindrone