[Changes in the nephron and neuroendocrine apparatus of the kidneys following the administration of Salmonella endotoxin].
Electron microscopy was used to examine renal glomerules and tubules, as well as the renal neuro-endocrine apparatus 3 and 24 hours after intravenous injection of 2 mg/kg S. typhimurium endotoxin. The studies demonstrated swelling and vacuolization of the endothelial cells and an increase in the glomerular capillaries of the number of polymorphonuclear leukocytes with lysosomal sequestration and fibrin emergence 3 hours after endotoxin injection, intravascular coagulation, accumulation of polymorphonuclear leukocytes in the peritubular capillaries, fat dystrophy of the mesangial cells and nephrocytes in the proximal tubules after 24 hours. The method for mathematical estimation of granulation in the juxtaglomerular apparatus (JGA), designed by the authors, from the density of the contents of epithelioid cell granules enabled the detection of JGA activation, particularly 24 hours after endotoxin injection. The reduction of the number of granules in the interstitial cells of the renal medulla might be due both to JGA activation and endotoxin action that stimulates the synthesis of prostaglandins.
D000818:Animals; D004731:Endotoxins / Q000633:toxicity*; D008854:Microscopy, Electron; D009399:Nephrons / Q000187:drug effects* / Q000648:ultrastructure; D009490:Neurosecretory Systems / Q000187:drug effects* / Q000648:ultrastructure; D011817:Rabbits; D012486:Salmonella typhimurium; D013997:Time Factors
D004731:Endotoxins
Izmeneniia nefrona i neĭroéndokrinnykh apparatov pochek posle vvedeniia sal'monelleznogo éndotoksina.