title: Progress in acute myelogenous leukemia.
abstract: There has been substantial recent progress in the treatment of acute myelogenous leukemia (AML). Intensive induction chemotherapy with cytosine arabinoside and daunorubicin with or without 6-thioguanine will induce remission in over 70% of patients, with median remission of 1-2 years in most series. Attempts to prolong remissions with  maintenance chemotherapy, immunotherapy, late intensification or central nervous system prophylaxis have been disappointing and there are no convincing data that these modalities are useful. Nevertheless, an increasing proportion of patients with AML have remissions of 3 or more years, and a small proportion may be cured.
mesh_terms: D016026:Bone Marrow Transplantation; D002986:Clinical Trials as Topic; D003561:Cytarabine / Q000008:administration & dosage*; D003630:Daunorubicin / Q000008:administration & dosage*; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006087:Graft vs Host Reaction; D006801:Humans; D007167:Immunotherapy; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000401:mortality / Q000628:therapy; D008875:Middle Aged; D013866:Thioguanine / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D003561:Cytarabine; D004317:Doxorubicin; D013866:Thioguanine; D003630:Daunorubicin