The effect of ampicillin on skin graft survival and antibody response in B6A F1 mice.
The effect of ampicillin on the immune response to sheep red blood cells (SRBC) and on the survival of BALB/c skin allograft in B6A F1 mice was studied. At the non-toxic doses of 250-500 mg/kg per day, given repeatedly before or after injection of SRBC or skin grafting, there was a marked enhancement of the antibody response and a prolongation of skin graft survival from 12.7 +/- 0.23 days in untreated mice to 13.7 +/- 0.19 days and 15.2 +/- 0.75 days in mice treated before or after skin grafting, respectively.
D000667:Ampicillin / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D012756:Sheep; D016038:Skin Transplantation; D013997:Time Factors
D000667:Ampicillin