title: [Synthesis of an insulin-like growth factor I hybrid insulin (author's transl)].
abstract: Stepwise Edman degradation of the insulin B chain is achieved after reversible protection of the amino groups in A1 and B29 with the acid-stable methylsulfonylethyloxycarbonyl residue. Condensation of the protected N-terminal tetrapeptide of insulin-like growth factor I with the degraded insulin yields an hybrid insulin whose synthesis and biological properties are discussed.
mesh_terms: D000595:Amino Acid Sequence; D007202:Indicators and Reagents; D007328:Insulin; D046911:Macromolecular Substances; D008722:Methods; D010455:Peptides; D011384:Proinsulin; D055503:Protein Multimerization; D013002:Somatomedins
chemical_list: D007202:Indicators and Reagents; D007328:Insulin; D046911:Macromolecular Substances; D010455:Peptides; D013002:Somatomedins; D011384:Proinsulin
vernacular_title: Synthese eines "Insulin-Like Growth Factor I"-Hybrid-Insulins.