Human amniotic fluid alpha-glucosidase.
Amniotic fluid in midpregnancy contains significant alpha-glucosidase activity. This enzyme is distinguishable from the lysosomal acid alpha-glucosidase, deficiency of which is associated with Pompe's disease. The two enzymes differ in optimum pH, thermal stability, electrophoretic migration, isoelectric point, molecular mass, and immunological response. Amniotic alpha-glucosidase is also different from the classical neutral form. Immuno-cross reactions suggest that the amniotic fluid enzyme has a double fetal origin: renal and intestinal. It seems that alpha-glucosidase in amniotic fluid is linked to lipids.
D000653:Amniotic Fluid / Q000201:enzymology*; D004586:Electrophoresis; D005260:Female; D005959:Glucosidases / Q000032:analysis*; D006358:Hot Temperature; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007106:Immune Sera / Q000276:immunology; D007525:Isoelectric Focusing; D008970:Molecular Weight; D011247:Pregnancy; D000520:alpha-Glucosidases / Q000032:analysis* / Q000276:immunology
D007106:Immune Sera; D005959:Glucosidases; D000520:alpha-Glucosidases