title: [Effect of pyrolysis products of polypropylene plastic on the defence mechanisms of the respiratory system (author's transl)].
abstract: Since the use of plastic materials, a change in the pathology of fire victims has been observed. We studied the effects of a single short-term inhalation (30 min) of a sub-lethal dose of polypropylene pyrolysis products (one LD-0). Including control and test animals, 66 rats and 112 mice were used. The exposure provoked disturbances in the antixenic defense mechanisms of the respiratory system, chiefly in tracheo-bronchial defenses, since we observed a lowering of ciliary activity of 35 to 78% in test animals exposed a few hours before, compared with the controls. These changes provoked a significant increase in death-rate of test animals, following experimental airborne infection by Klebsiella pneumoniae. The combustion products of polypropylene plastic materials did not contain hydrocyanic acid nor hydrochloric acid, and neither the temperature of the inhaled air, nor the concentration of carbon monoxide could explain these effects. On the contrary, we can suspect the well known irritative properties of aldehyde compounds formed during smoldering combustion of polypropylene.
mesh_terms: D000391:Air Microbiology; D000818:Animals; D002923:Cilia / Q000502:physiology; D006358:Hot Temperature; D007710:Klebsiella Infections / Q000276:immunology; D007711:Klebsiella pneumoniae / Q000276:immunology; D008264:Macrophages / Q000502:physiology; D008297:Male; D051379:Mice; D010969:Plastics / Q000009:adverse effects*; D011126:Polypropylenes / Q000009:adverse effects*; D011650:Pulmonary Alveoli / Q000502:physiology; D051381:Rats; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000187:drug effects*; D014132:Trachea / Q000502:physiology
chemical_list: D010969:Plastics; D011126:Polypropylenes
vernacular_title: Effet du pyrolysat de matière plastique polypropylénique sur les mécanismes de défense de l'appareil respiratoire.