title: Multienzymatic proteins in mammalian pyrimidine biosynthesis: channeling of intermediates to avoid futile cycles.
mesh_terms: D000818:Animals; D001221:Aspartate Carbamoyltransferase; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); D002286:Carcinoma, Ehrlich Tumor / Q000201:enzymology; D004080:Dihydroorotase; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D051379:Mice; D009097:Multienzyme Complexes / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D009962:Orotate Phosphoribosyltransferase / Q000378:metabolism; D009964:Orotidine-5'-Phosphate Decarboxylase / Q000378:metabolism; D011743:Pyrimidines / Q000096:biosynthesis*; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D014542:Uridine Monophosphate / Q000378:metabolism
chemical_list: C033626:CAD trifunctional enzyme; D009097:Multienzyme Complexes; D009363:Neoplasm Proteins; D011743:Pyrimidines; D014542:Uridine Monophosphate; D001221:Aspartate Carbamoyltransferase; D009962:Orotate Phosphoribosyltransferase; D004080:Dihydroorotase; D009964:Orotidine-5'-Phosphate Decarboxylase; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)