Effect of glucagon on ethanol oxidation in isolated rat liver cells.
Addition of glucagon 5 min after ethanol was found to stimulate the rate of ethanol oxidation in hepatocytes isolated from starved rats. This stimulation is of the same order of magnitude as that mediated by asparagine. The glucagon effect is suppressed by antiproteolytic agents such as insulin or NH4Cl. The stimulating effect of glucagon on ethanol oxidation is probably linked to enhanced proteolysis and an elevated glutamate level in the hepatocytes.
D000643:Ammonium Chloride / Q000494:pharmacology; D000818:Animals; D001215:Asparaginase / Q000494:pharmacology; D000431:Ethanol / Q000378:metabolism*; D005260:Female; D005934:Glucagon / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats
D007328:Insulin; D000643:Ammonium Chloride; D000431:Ethanol; D005934:Glucagon; D001215:Asparaginase