Neutropenia induced by platelet-activating factor (PAF-acether) released from neutrophils: the inhibitory effect of prostacyclin (PGI2).
Soluble and phagocytic stimuli released PAF-acether from PMN leucocytes, as determined by chromatography and bioassay by platelet aggregation. The same material caused aggregation of human and rabbit PMN leucocytes in vitro which was inhibited by ETYA and PGI2. PGI2 also inhibited PAF-acether release by PMN leucocytes and, in vivo, PGI2 abolished not only PAF-acether-induced, but also immune complex or C5a-induced thrombocytopenia and neutropenia in rabbits. These data suggest that PAF-acether may be involved in activation of both platelets and PMN leucocytes in vivo.
D000380:Agranulocytosis / Q000209:etiology*; D000818:Animals; D002449:Cell Aggregation / Q000187:drug effects; D011464:Epoprostenol / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008244:Lysophosphatidylcholines / Q000502:physiology*; D009503:Neutropenia / Q000209:etiology*; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D010972:Platelet Activating Factor; D011453:Prostaglandins / Q000494:pharmacology*; D011817:Rabbits
D008244:Lysophosphatidylcholines; D010972:Platelet Activating Factor; D011453:Prostaglandins; D011464:Epoprostenol