title: Bacterial mutation test on plafibride.
abstract: N-2-(p-Chlorophenoxy)-isobutyryl-N'-morpholinomethylurea (plafibride, ITA 104) was tested for mutagenic activity of the Ames Salmonella/mammalian microsome test. Salmonella typhimurium strains TA 1535, TA 1537, TA 1538, TA 98 and TA 100 were employed. Two of these strains (TA 1535 and TA 100) are sensitive to base pair substitution mutagens, whilst the remaining three are sensitive to frame-shift mutagens. No evidence of mutagenic activity of plafibride was observed either in the presence or absence of a liver microsomal supplement.
mesh_terms: D000818:Animals; D002994:Clofibrate / Q000031:analogs & derivatives*; D002995:Clofibric Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D066298:In Vitro Techniques; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics*
chemical_list: D009153:Mutagens; D002995:Clofibric Acid; C016894:plafibride; D002994:Clofibrate