Reflections on the role of carbon haemoadsorption in therapeutic medicine.
The selection of Norit RBX-1-activated carbon granules for blood detoxification by haemoadsorption is outlined. Synthetic polymer membranes have been coated on to this carbon by a specially developed process and perfusion devices prepared from these materials have been evaluated in animal models of acute poisoning and liver failure. Clinical application of carbon haemoadsorption has been explored in acute poisoning, liver failure and uraemia. The experience to date would suggest that carbon will have to be augmented by other adsorbent species before life support systems based principally on haemoadsorption become a reality especially in the treatment of uraemia and in liver failure. A secondary role as a temporary adjunct to dialysis has been established for carbon haemoperfusion in the treatment of uraemic pericarditis and is under further investigation in the treatment of pruritus, pigmentation and neuropathy.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000627:therapeutic use*; D002244:Carbon / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004285:Dogs; D006464:Hemoperfusion; D006498:Hepatectomy; D006501:Hepatic Encephalopathy / Q000188:drug therapy; D007164:Immunosorbents / Q000627:therapeutic use*; D008297:Male; D011041:Poisoning / Q000188:drug therapy*; D051381:Rats; D014511:Uremia / Q000188:drug therapy
D000936:Antigen-Antibody Complex; D007164:Immunosorbents; D002244:Carbon