Capoten-induced juxtaglomerular hyperplasia in rabbits.
The effects of the converting enzyme (CE) inhibitor, captopril, on blood pressure, plasma aldosterone, plasma renin activity (PRA), and kidney morphology were studied. Captopril, at a near maximum daily recommended human dose of approximately 5.0 mg/kg, was administered to rabbits over a period of six months. Mean arterial pressure, CE activity, and aldosterone levels were significantly reduced; PRA and renal renin activity were increased. Microscopic examination of the kidney showed marked hyperplasia of the juxtaglomerular apparatus in all of the treated animals.
D000450:Aldosterone / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D006965:Hyperplasia / Q000139:chemically induced; D007606:Juxtaglomerular Apparatus / Q000187:drug effects* / Q000473:pathology; D008297:Male; D011392:Proline / Q000031:analogs & derivatives*; D011817:Rabbits; D012083:Renin / Q000096:biosynthesis
D000450:Aldosterone; D011392:Proline; D002216:Captopril; D012083:Renin