Statistical analysis of the Ames Salmonella/microsome test.
A family of statistical models for analysis of Ames Salmonella/microsome test data is constructed that considers mutation and toxicity as competing risks and allows hyper-Poisson variability. These models have a parameter than can be employed as a mutagenic index because it approximates the slope at zero dose of a dose-response curve adjusted for toxicity. A second parameter quantifies plate-to-plate variability and lends itself to the study of factors affecting internal test reproducibility. The detection of aberrant plate counts is also addressed. This methodology is illustrated with data from a Salmonella test.
D000818:Animals; D008862:Microsomes, Liver / Q000201:enzymology; D008954:Models, Biological; D009152:Mutagenicity Tests / Q000592:standards*; D009154:Mutation; D011804:Quinolines / Q000633:toxicity; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects*; D013223:Statistics as Topic
D011804:Quinolines