Cimetidine and fat malabsorption in children with cystic fibrosis.
Under controlled clinical observation we administered Cimetidine (600 mg/m2/day) in 10 children with cystic fibrosis. All patients received identical diets (40% fat, 45% carbohydrate, 15% protein) as well as same standardized enzyme preparation (lyophilised whole pancreas). 3-day fecal fat and nitrogen excretion analyses were performed. After 6 days of Cimetidine therapy, an improvement of fat and nitrogen absorption could be detected in 5 patients. Statistical analysis of the group as a whole showed no improvement in fat absorption coefficients. We conclude that this drug therapy should only be recommended for routine clinical use after long-term trials have shown a real improvement of absorption.
D000293:Adolescent; D002648:Child; D002927:Cimetidine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003550:Cystic Fibrosis / Q000188:drug therapy* / Q000378:metabolism; D004041:Dietary Fats / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D009584:Nitrogen / Q000378:metabolism
D004041:Dietary Fats; D006146:Guanidines; D002927:Cimetidine; D009584:Nitrogen