2,3-Biphosphoglycerate, inorganic phosphate, pH and hemoglobin concentration in chronic renal failure of man.
In a group of 69 patients with chronic renal failure, 18 patients after renal transplantation and 8 healthy controls the influence of inorganic phosphate and pH of plasma and of the hemoglobin concentration in whole blood on the 2,3-DPG concentration in red blood cells was investigated. The data were treated by linear regression analysis as well as by multivalent correlation analysis with graph-theoretical methods. Hemoglobin and inorganic phosphate are the factors of renal importance for the 2,3-DPG concentration. The pH affects 2,3-DPG directly (positively) and indirectly via inorganic phosphate (negatively). Therefore, the influence of pH on 2,3-DPG usually observed is abolished in this group of patients. Determinations of inorganic phosphate and hemoglobin seem to be valuable for the diagnosis of the 2,3-DPG-dependent oxygen transport function during chronic renal failure. All the parameters studied were found to be normalized in the group of patients after renal transplantation.
D019794:2,3-Diphosphoglycerate; D004163:Diphosphoglyceric Acids / Q000097:blood*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007676:Kidney Failure, Chronic / Q000097:blood*; D016030:Kidney Transplantation; D007700:Kinetics; D010710:Phosphates / Q000097:blood*; D012016:Reference Values
D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D010710:Phosphates; D019794:2,3-Diphosphoglycerate