title: Formaldehyde in dentistry: a review of mutagenic and carcinogenic potential.
abstract: For many years there has been controversy over the value of antimicrobial drugs for intracanal dressings in endodontics. Formocresol, a formaldehyde compound, has evolved as the preferred drug for routine endodontic procedures, as well as pediatric endodontics. The increase in the use of formaldehyde has been complicated by the introduction of paraformaldehyde pastes for filling root canals. Neither of these formulas has ever been standardized. The doses are arbitrary, and the common dose of formocresol has been shown to be many times greater than the minimum dose needed for effect. The efficacy of paraformaldehyde pastes is questionable and remains clouded by inconclusive evidence, conflicting research, inadequate terminology, and a lack of convincing statistical evidence. The clinical use and delivery of formocresol and paraformaldehyde pastes remain arbitrary and unscientific. Formaldehyde has a known toxic mutagenic and carcinogenic potential. Many investigations have been conducted to measure the risk of exposure to formaldehyde; it is clear that formaldehyde poses a carcinogenic risk in humans. There is a need to reevaluate the rationale underlying the use of formaldehyde in dentistry particularly in light of its deleterious effects.
mesh_terms: D002273:Carcinogens; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003408:Cresols / Q000009:adverse effects; D003764:Dental Materials / Q000009:adverse effects*; D004338:Drug Combinations / Q000009:adverse effects; D004781:Environmental Exposure; D005557:Formaldehyde / Q000009:adverse effects*; D005566:Formocresols / Q000009:adverse effects; D006801:Humans; D009152:Mutagenicity Tests; D009153:Mutagens
chemical_list: D002273:Carcinogens; D003408:Cresols; D003764:Dental Materials; D004338:Drug Combinations; D005566:Formocresols; D009153:Mutagens; D005557:Formaldehyde; C031025:formocresol