title: The pharmacokinetics of antibiotic diffusion in chronic bacterial prostatitis.
abstract: Historically chronic bacterial prostatitis in the male human has been relatively resistant to antimicrobial chemotherapy. The pharmacokinetic theory of drug diffusion into the prostate is reviewed. A brief description of the various canine models utilized to quantitate antimicrobial drug diffusion is presented. Specific data concerning the diffusion of various antimicrobial agents are abstracted followed by a brief discussion of mechanistic explanations for the success or failure of drug therapy.
mesh_terms: D000617:Aminoglycosides / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D000892:Anti-Infective Agents, Urinary / Q000378:metabolism; D001424:Bacterial Infections / Q000378:metabolism*; D002511:Cephalosporins / Q000378:metabolism; D002908:Chronic Disease; D004285:Dogs; D007700:Kinetics; D008297:Male; D010406:Penicillins / Q000378:metabolism; D011472:Prostatitis / Q000209:etiology / Q000378:metabolism*; D013449:Sulfonamides / Q000378:metabolism; D013752:Tetracycline / Q000378:metabolism; D014295:Trimethoprim / Q000378:metabolism
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000892:Anti-Infective Agents, Urinary; D002511:Cephalosporins; D010406:Penicillins; D013449:Sulfonamides; D014295:Trimethoprim; D013752:Tetracycline