Antitumor activity of intralesionally administered Nocardia opaca preparations in rat and mouse tumors: a comparison with BCG and Corynebacterium parvum.
Three Nocardia products: delipidated cells, lysozyme digest and Nocardia Water Soluble Mitogen (NW SM), have been assayed in regression experiments and compared with living BCG and killed C. parvum in rat and mouse fibrosarcomas transplanted intradermally. Intratumor injection of these Nocardia products induced regression in the BCG sensitive McFiFi2 (S) tumor. These substances were active at a dose of 1 mg, the lysozyme extract and NW SM also being active at 0.1 mg. Association with mineral or vegetable oil increased the efficiency of delipidated cells, and under these conditions, regression of tumors implanted contralaterally to treated tumors was also obtained.
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002458:Cell Fractionation; D004305:Dose-Response Relationship, Drug; D007267:Injections; D051379:Mice; D008809:Mice, Inbred C3H; D009163:Mycobacterium bovis / Q000276:immunology; D009374:Neoplasms, Experimental / Q000276:immunology*; D009615:Nocardia / Q000276:immunology*; D011425:Propionibacterium acnes / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains
D000972:Antineoplastic Agents, Phytogenic