Glycerophosphate acetyltransferase activity in perfused liver of normal and hyperlipemic rats: glucagon effect.
Mitochondrial glycerophosphate-acetyltransferase activity (GPAT) was determined in the isolated and perfused liver of diet-induced hyperlipemic rats, and was found to be significantly increased compared to normal rats, A positive correlation existed between hepatic triglyceride output and GPAT. Perfusion of 10(-5) M glucagon induced a significant reduction in GPAT levels. It is suggested that the lipid-lowering action of glucagon may be mediated also through an inhibition of GPAT activity.
D000217:Acyltransferases / Q000378:metabolism*; D000818:Animals; D005934:Glucagon / Q000097:blood / Q000494:pharmacology*; D005992:Glycerol-3-Phosphate O-Acyltransferase / Q000378:metabolism*; D006949:Hyperlipidemias / Q000201:enzymology*; D007328:Insulin / Q000097:blood; D007657:Ketone Bodies / Q000097:blood; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism
D007328:Insulin; D007657:Ketone Bodies; D014280:Triglycerides; D005934:Glucagon; D000217:Acyltransferases; D005992:Glycerol-3-Phosphate O-Acyltransferase