Effect of chronic diuretic treatment on the plasma renin-angiotensin-aldosterone system in essential hypertension.
1 Chronic treatment with a constant dose of hydrochlorothiazide or tienilic acid increases plasma renin activity (PRA) acutely to reach a maximum within the first week. 2 During chronic diuretic therapy from 1 month to 1 year, PRA remained elevated at a rather constant level, though this was somewhat lower than the maximum level reached after 1 week. 3 A significant (P less than 0.01) correlation (r = 0.74) between changes in plasma angiotensin II and renin activity provoked by chronic treatment for 3 months with hydrochlorothiazide and tienilic acid was found. 4 The increase in plasma aldosterone during chronic treatment with hydrochlorothiazide and tienilic acid (1000 mg) is related (r = 0.68; P less than 0.01) to the rise in plasma angiotensin II.
D000328:Adult; D000450:Aldosterone / Q000097:blood*; D000809:Angiotensins / Q000097:blood*; D004232:Diuretics / Q000494:pharmacology* / Q000627:therapeutic use; D004573:Electrolytes / Q000097:blood; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008297:Male; D012083:Renin / Q000097:blood*; D013989:Ticrynafen / Q000494:pharmacology; D013997:Time Factors
D000809:Angiotensins; D004232:Diuretics; D004573:Electrolytes; D006852:Hydrochlorothiazide; D000450:Aldosterone; D012083:Renin; D013989:Ticrynafen