Mutagenicity of experimental inhalational anesthetic agents: sevoflurane, synthane, dioxychlorane, and dioxyflurane.
A modification of the Ames bacterial assay system employing two histidine-dependent strains of Salmonella typhimurium, TA1535 and TA100, was used to test the mutagenicity of four experimental, inhalational anesthetic agents: sevoflurane, synthane, dioxychlorane, and dioxyflurane. None of the anesthetics was mutagenic. Increased activity was seen only with vinylidene chloride, the positive control.
D000777:Anesthetics / Q000633:toxicity*; D000818:Animals; D004148:Dioxolanes / Q000633:toxicity; D004987:Ethers / Q000633:toxicity; D006845:Hydrocarbons, Fluorinated / Q000633:toxicity; D008738:Methyl Ethers; D009153:Mutagens; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics; D000077149:Sevoflurane; D005466:Fluorocarbons
D000777:Anesthetics; D004148:Dioxolanes; D004987:Ethers; D006845:Hydrocarbons, Fluorinated; D008738:Methyl Ethers; D009153:Mutagens; D000077149:Sevoflurane; C006175:difluoromethyl 1,2,2,3,3-pentafluoropropyl ether; D005466:Fluorocarbons; C034810:dioxyflurane; C022935:dioxychlorane