Induced gene mutation and mitotic non-disjunction in A. nidulans.
Toxicants of different classes were analysed for capacity to induce gene mutation and mitotic non-disjunction in Aspergillus nidulans, using selective and permissive tests, respectively. Ethanol, Amphotericin B and MIcanozole, all affecting membrane integrity, induced only non-disjunction, emphasizing the röle of the membrane in mitosis. Benomyl and isopropyl-3-chlorophenyl carbamate (CIPC), two pesticides which interfere with spindle system, induced only non-disjunction. Conversely, mitomycin C markedly increased mutation rate but not ono-disjunction and scarcely affected the viability. The comparative analysis of these two different genetic damages should prove useful in evaluating hazards of drugs.
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001233:Aspergillus nidulans / Q000187:drug effects* / Q000235:genetics; D002869:Chromosome Aberrations; D000431:Ethanol / Q000494:pharmacology; D005796:Genes / Q000187:drug effects*; D008938:Mitosis / Q000187:drug effects; D009154:Mutation; D010575:Pesticides / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010575:Pesticides; D000431:Ethanol