[Therapeutic action of proteolytic enzymes and antibiotics in experimental staphylococcal infection. The effect of lincomycin, chymotrypsin and their combinations on the level of autoplaque-forming cells in the blood and the immune adherence reaction of staphylococci].
The effect of lincomycin, chymotrypsin and their combination on the blood count of the plaque-autoforming cells (PAFC) and immune adhesion (IA) of staphylococci was studied on mice with staphylococcal infection. The infected mice were divided into 4 groups: nontreated, lincomycin treated, chymotrypsin treated, and lincomycin + chymotrypsin treated. The doses of lincomycin and chymotrypsin were 150 and 2 mg/kg, respectively. The mice were decapitated by the 3rd, 7th, 14th or 21st day of the infection and treatment and the blood was collected for the count of the PAFC and IA. A decrease in the rate of IA with a simultaneous increase in the PAFC count was found in the untreated mice and the mice treated with lincomycin alone. The use of chymotrypsin and its combination with lincomycin stimulated IA and lowered the level of autosensibilization.
D000818:Animals; D002918:Chymotrypsin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006462:Hemolytic Plaque Technique; D007104:Immune Adherence Reaction; D008034:Lincomycin / Q000627:therapeutic use*; D051379:Mice; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000276:immunology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000276:immunology
D008034:Lincomycin; D002918:Chymotrypsin
O nekotorykh aspektakh lechebnogo deĭstviia proteoliticheskikh fermentov i antibiotikov pri éksperimental'noĭ stafilokokkovoĭ infektsii. Vliianie linkomitsina, khimotripsina i ikh sochetaniĭ na soderzhanie autobliashkoobrazuiushchikh kletok v krovi i reaktsiiu immunnogo prilipaniia stafilokokkov.