Fluctuations of free choline levels in plasma of Alzheimer patients receiving lecithin: preliminary observations.
Plasmas of 12 patients currently taking part in a double-blind trial of lecithin in senile or presenile dementia of Alzheimer type were analysed for plasma choline levels at fixed intervals during lecithin treatment. The values were not maintained at a constant level and showed a decline after one or two months of treatment, often followed by a subsequent rise. Possible explanations for this observation are given, and its significance to the treatment of dementia discussed.
D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000188:drug therapy; D002794:Choline / Q000097:blood*; D002986:Clinical Trials as Topic; D003704:Dementia / Q000097:blood*; D004311:Double-Blind Method; D006801:Humans; D008875:Middle Aged; D010349:Patient Compliance; D010713:Phosphatidylcholines / Q000627:therapeutic use*
D010713:Phosphatidylcholines; D002794:Choline