The protective effect of clavulanic acid in a combined formulation on the concentration of amoxycillin in the urine of patients with urinary tract infections.
Three paraplegic patients with urinary tract infections caused by a beta-lactamase-producing Klebsiella pneumoniae were treated with a combination of amoxycillin and clavulanic acid (A-CA) (Augmentin; Beecham), after initial and unsuccessful therapy with amoxycillin alone. The administration of A-CA resulted in a rapid decrease in the urinary bacterial cell count, coupled with a dramatic increase in urinary amoxycillin concentrations.
D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage / Q000652:urine*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001437:Bacteriuria / Q000378:metabolism; D019818:Clavulanic Acid; D004338:Drug Combinations; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy*; D007711:Klebsiella pneumoniae / Q000302:isolation & purification; D007769:Lactams / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000652:urine
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D007769:Lactams; D019818:Clavulanic Acid; D000658:Amoxicillin