Plasma zinc and iron concentrations as measurements for evaluating the influence of endotoxin-neutralizing agents in Escherichia coli endotoxin-induced mastitis.
The influence of bacterial lipopolysaccharides on plasma Zn and Fe concentrations and the endotoxin-neutralizing capacity of polymyxin B was studied in 3 dairy cows. Also, the feasibility of using plasma Zn and Fe concentrations as measurements for evaluating the influence of endotoxin-neutralizing agents in Escherichia coli endotoxin-induced mastitis was studied. A positive relationship was ascertained between the dose of endotoxin given intramammarily (IMM) and the effect on mean values of plasma Zn and Fe concentrations. Seemingly, IMM administration of polymyxin B-sulfate before the IMM administration of E coli endotoxin partially blocked the effects of endotoxin, as shown by decreases in plasma Zn and Fe.
D000818:Animals; D002417:Cattle; D004731:Endotoxins; D004926:Escherichia coli; D004927:Escherichia coli Infections / Q000097:blood* / Q000188:drug therapy; D005260:Female; D007501:Iron / Q000097:blood*; D008414:Mastitis, Bovine / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D011112:Polymyxin B / Q000627:therapeutic use; D015032:Zinc / Q000097:blood*
D004731:Endotoxins; D007501:Iron; D011112:Polymyxin B; D015032:Zinc