title: [Mutagenicity of twelve imidazole derivatives with trichomonacide activity].
abstract: The mutagenic action of twelve imidazole derivatives was investigated by Salmonella/microsome assay. All of them were mutagenic on TA 100 without metabolic activation. No direct relationship between antitrichomonad action in vitro and mutagenicity was established. As the compound XII showed much less mutagenic activity compared to the other imidazoles, we propose to perform more mutagenic studies on the chemical analogues of this drug.
mesh_terms: D000818:Animals; D000994:Antitrichomonal Agents / Q000633:toxicity*; D007093:Imidazoles / Q000633:toxicity*; D008862:Microsomes, Liver / Q000187:drug effects; D009152:Mutagenicity Tests; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D000994:Antitrichomonal Agents; D007093:Imidazoles
vernacular_title: Mutagenicità di dodici composti imidazolici ad attività tricomonicida.