The expression of human chorionic gonadotropin in the female genital tract: localization by the immunoperoxidase technique.
Four hundred eighty-eight lesions from 456 patients were surveyed for the production of hCG using the immunoperoxidase technique. HCG immunoreactivity was found in 9.1% of the total number of cases studied. The 10% of ovarian cancers expressing hCG included serous, endometrioid, and germ cell tumors. Eighteen point nine percent of neoplastic cervices were positive for hCG; the highest rate of expression was in invasive cancers. Eighteen point nine percent of endometrial cancers were hCG positive; poorly differentiated tumors had the highest percent of marker expression. The significance of "ectopic" hCG expression in nontrophoblastic gynecologic neoplasms is discussed.
D002294:Carcinoma, Squamous Cell / Q000032:analysis; D006063:Chorionic Gonadotropin / Q000032:analysis*; D005260:Female; D005833:Genital Neoplasms, Female / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D010051:Ovarian Neoplasms / Q000032:analysis; D013724:Teratoma / Q000032:analysis; D014594:Uterine Neoplasms / Q000032:analysis
D006063:Chorionic Gonadotropin