Change in i-antigen expression of erythrocytes during in vivo aging.
The expression of i-antigen during the in vivo aging of erythrocytes from normal subjects and beta-thalassemic patients was investigated by immunofluorescence labeling and by immunoagglutination. The results showed that the expression of i-antigenic determinants inversely related to the aging of RBCs. This phenomenon could be either the result of a progressive loss of i-antigenic structures or the consequence of i to I transformation occurring during RBCs aging in vivo.
D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood; D000818:Animals; D001789:Blood Group Antigens; D002470:Cell Survival; D004912:Erythrocytes / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007048:I Blood-Group System; D011817:Rabbits; D013789:Thalassemia / Q000097:blood
D001789:Blood Group Antigens; D007048:I Blood-Group System