Monocytotoxic antibodies after bone marrow transplantation in aplastic anemia.
Pre- and post transplant sera from 51 cases of bone marrow transplants performed for severe aplastic anemia were tested on monocytes (M) and corresponding B cells (B) from a panel of unrelated donors. One-third of the sera were cytotoxic for B and M either from different or from the same individuals, while 45% reacted only to M and appeared to recognize non-HLA M-associated antigens. No significant reaction to endothelial cells was obtained from these sera. The subsequent clinical course was not associated with any reaction pattern of pre-transplant sera. There was a significant relationship between rejection and the development of M antibodies after grafting, but since these were also found in many other patients without rejection, their occurrence has no predictive value for an individual patient.
D000741:Anemia, Aplastic / Q000276:immunology* / Q000628:therapy; D001402:B-Lymphocytes / Q000276:immunology; D016026:Bone Marrow Transplantation; D003602:Cytotoxicity, Immunologic; D004727:Endothelium / Q000276:immunology; D005260:Female; D006084:Graft Rejection; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D007518:Isoantibodies / Q000096:biosynthesis*; D007668:Kidney / Q000276:immunology; D008297:Male; D009000:Monocytes / Q000276:immunology*
D006680:HLA Antigens; D007518:Isoantibodies