Mutagenicity testing of chlorinated biphenyls and chlorinated dibenzofurans.
4 chlorinated biphenyl and 5 chlorinated dibenzofuran compounds have been evaluated in the reversion assay developed by B.N Ames using Salmonella typhimurium histidine auxotrophs. All these compounds (2,4,2'-4'-tetrachlorobiphenyl, 3,4,3',4'-tetrachlorobiphenyl, 4-chlorobiphenyl, 2,4,,6,2',4',6'-hexachlorobiphenyl, dibenzofuran, 2,9-dichlorodibenzofuran, 3,6-dichlorodibenzofuran, 2,3,7,8-tetrachlorodibenzofuran and octachlorodibenzofuran) were nonmutagenic for strains TA98 and TA100 when tested over a 3-log dose range. They were also not mutagenic whether or not varying concentrations of microsomal extracts (S9) from uninduced rats or from rats induced by several methods were included in the experimental protocol.
D000818:Animals; D001572:Benzofurans / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology*; D006843:Hydrocarbons, Chlorinated / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics
D001572:Benzofurans; D001713:Biphenyl Compounds; D006843:Hydrocarbons, Chlorinated; D009153:Mutagens