Translational control of ribosomal protein L10 synthesis occurs prior to formation of first peptide bond.
A simplified DNA-directed in vitro system has been developed to study the regulation of the synthesis of ribosomal protein L10 by measuring the formation of the first dipeptide, fMet-Ala. The results show that the inhibition of L10 synthesis by L10 (autoregulation) occurs at or prior to the formation of the first peptide bond.
D002474:Cell-Free System; D004151:Dipeptides / Q000096:biosynthesis; D004926:Escherichia coli / Q000235:genetics*; D005786:Gene Expression Regulation; D006159:Guanosine Tetraphosphate / Q000494:pharmacology; D010442:Peptide Chain Initiation, Translational; D014176:Protein Biosynthesis; D000080882:Ribosomal Protein L10; D012269:Ribosomal Proteins / Q000096:biosynthesis / Q000235:genetics*
D004151:Dipeptides; D012269:Ribosomal Proteins; D006159:Guanosine Tetraphosphate