Morphological changes induced by heterologous antibodies in the rat liver.
The dynamics of organ fixation of heterologous antibodies were studied with the immunofluorescent technique. This allowed to conclude to the presence of liver-specific antibodies in the immune serum on the basis of the tissue fixation of antibodies. A perivascular round cell infiltration is characteristic of the liver damage induced by antibodies. Dilatation of the rough endoplasmic cisterns and a condensation of the matrix was revealed by electron microscopic pictures. It is concluded on the basis of the regressive phenomena and of the mesenchymal reactions that some importance can be attached to humoral immunity in immunopathological processes.
D000818:Animals; D000910:Antibodies, Heterophile / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D007136:Immunoglobulins / Q000032:analysis; D008099:Liver / Q000033:anatomy & histology / Q000276:immunology* / Q000648:ultrastructure; D008853:Microscopy; D008854:Microscopy, Electron; D051381:Rats; D013997:Time Factors
D000910:Antibodies, Heterophile; D007136:Immunoglobulins