Does cadmium exposure reduce the metabolism of ethanol?
It is proposed that persons exposed to elevated levels of cadmium via occupation, diet, or cigarette smoking will exhibit a diminished capability to metabolize ethanol via the action of the zinc dependent enzyme, alcohol dehydrogenase (ADH). This follows from the observation that cadmium can replace the zinc in liver ADH and inactivate it.
D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000818:Animals; D002104:Cadmium / Q000494:pharmacology; D002105:Cadmium Poisoning / Q000378:metabolism* / Q000473:pathology; D000431:Ethanol / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000201:enzymology; D008297:Male; D012907:Smoking; D015032:Zinc / Q000378:metabolism
D002104:Cadmium; D000431:Ethanol; D000429:Alcohol Oxidoreductases; D015032:Zinc