A comparison of the effects of prostaglandins E2 and I2 on renal function and renin release in salt-loaded and salt-depleted anaesthetized dogs.
Prostaglandin E2 (PGE2) and prostaglandins I2 (PGI2) were infused into the renal artery of either sodium-loaded or sodium-depleted dogs. Systemic blood pressure was decreased and arterial plasma renin concentration increased in the sodium-loaded dogs by infusion of PGI2 (1200 ng/min). Both compounds increased renal blood flow but PGE2 had a much more potent effect than PGI2 on increasing urine flow and sodium excretion. In the sodium-depleted dogs systemic blood pressure was significantly decreased and arterial plasma renin concentration increased by infusions of PGI2 (300 and 1200 ng/min) and PGE2 (300 ng/min). Both compounds stimulated urine flow and renal blood flow but PGE2 induced a much larger increase in sodium excretion than PGI2. PGI2 exerts its actions on renal function by inducing vasodilatation whereas PGE2 also has a direct action on tubular function.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003864:Depression, Chemical; D004285:Dogs; D011464:Epoprostenol / Q000494:pharmacology*; D007668:Kidney / Q000098:blood supply / Q000187:drug effects*; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology*; D012039:Regional Blood Flow; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000502:physiology*; D013268:Stimulation, Chemical
D011453:Prostaglandins; D011458:Prostaglandins E; D012964:Sodium; D011464:Epoprostenol; D012083:Renin