Relapse of duodenal ulcer after treatment with trimipramine/antacids or cimetidine/antacids.
Ninety-three patients with duodenal ulcer were treated with trimipramine, 25 mg at night; cimetidine, 400 mg at night; or cimetidine, 1000 mg/day. In addition, all patients were given 20 ml antacids 1 and 3 h after meals. The healing rates after 6 weeks' treatment were 86%, 85%, and 100% in the three groups, respectively (differences not significant). After healing of the ulcers 88 of the patients were checked monthly during 1 year to study relapse rate. Endoscopy was performed on recurrence of symptoms suggesting relapse and after 6 and 12 months in all asymptomatic patients. Relapse was diagnosed in 64% of the patients in the trimipramine-treated group, in 48% in the 400 mg cimetidine group, and in 54% in th 1000 mg cimetidine group (differences not significant). The results suggest that ulcer recurrence is not commoner after treatment with standard dose of cimetidine than after a low dosage of cimetidine or trimipramine.
D000863:Antacids / Q000008:administration & dosage*; D002927:Cimetidine / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D003984:Dibenzazepines / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005500:Follow-Up Studies; D006146:Guanidines / Q000008:administration & dosage*; D006801:Humans; D014299:Trimipramine / Q000008:administration & dosage*
D000863:Antacids; D003984:Dibenzazepines; D006146:Guanidines; D014299:Trimipramine; D002927:Cimetidine