title: [Early jaundice after orthotopic liver transplantation. The role of ischaemia (author's transl)].
abstract: The purpose of this experimental study was to identify the cause of early cholestatic jaundice occurring after orthotopic liver transplantation. The role of ischaemia was investigated in dogs undergoing auto-transplantation of the liver preserved for two hours. The animals developed early cholestasis with lesions that were markedly different from the graft-rejection lesions observed in a control group, being restricted to the cells and canaliculi of the central lobular area. The results of this work have made it possible to avoid overdosage with immunosuppressive drugs in a patient who had recently undergone orthotopic liver transplantation.
mesh_terms: D000818:Animals; D001706:Biopsy; D002779:Cholestasis / Q000209:etiology*; D004285:Dogs; D006801:Humans; D007511:Ischemia / Q000150:complications; D008099:Liver / Q000201:enzymology / Q000473:pathology; D016031:Liver Transplantation; D008875:Middle Aged; D011183:Postoperative Complications; D013997:Time Factors; D014182:Transplantation, Autologous
vernacular_title: Ictère précoce après transplantation hépatique orthotopique. Le rôle de l'ischémie.