Effect of local urokinase on arterial occlusion of lower limbs.
Sixty nine patients were treated with local intra-arterial urokinase (37,500 U/CTA. hr-1) for recent severe ischemia of lower limbs: 27 (40%) ultimately required amputation. The difference of amputation rate between the groups with and without thrombolysis was not significant (33% v. 42%). A biological study in 6 patients showed that local arterial plasminemia occurred in only 1 patient. Local urokinase does not strongly stimulate "endogenous" thrombolysis and enhances "exogenous" thrombolysis only very inconstantly. A better adaptation of urokinase dosage or the use of an agent with higher affinity for fibrin might improve the efficiency of local thrombolytic therapy.
D000368:Aged; D000792:Angiography; D001161:Arteriosclerosis / Q000188:drug therapy; D002341:Carotid Artery Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy; D010450:Endopeptidases / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007122:Immunoelectrophoresis; D007269:Injections, Intra-Arterial; D007511:Ischemia / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D007866:Leg / Q000098:blood supply*; D008297:Male; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy; D014465:Ultrasonics; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*
D010450:Endopeptidases; D014568:Urokinase-Type Plasminogen Activator