The use of glycylhistidyllysine in culture systems.
Glycylhistidyllysine (GHL), a tripeptide isolated from plasma, has been shown to alter the growth rate of many cell types and organisms in culture systems. The tripeptide is optimally active at concentrations between 10 and 200 ng/ml. Some of the more interesting uses of GHL are highlighted in this paper. Present information suggests that GHL functions as a transporter of transition metals, in particular copper, to the cell surface for uptake into the cell.
D000818:Animals; D001200:Ascaris / Q000254:growth & development; D001692:Biological Transport / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects*; D003300:Copper / Q000378:metabolism; D003470:Culture Media; D006131:Growth Inhibitors; D006133:Growth Substances / Q000494:pharmacology*; D007962:Leukocytes / Q000166:cytology; D008114:Liver Neoplasms, Experimental; D009174:Mycoplasma / Q000254:growth & development; D009474:Neurons / Q000166:cytology; D009842:Oligopeptides / Q000494:pharmacology*
D003470:Culture Media; D006131:Growth Inhibitors; D006133:Growth Substances; D009842:Oligopeptides; C020905:glycyl-histidyl-lysine; D003300:Copper