Mutagen and anti-mutagen in ginger, Zingiber officinale.
When rhizome juice of ginger, zingiber officinale, was added to a solution of 2(2-furyl)-3(5-nitro-2-fury)acryl amide (AF2) or N-methyl-N'-nitro-N-nitrosoguanidine (NTG), mutagenesis by these chemicals was markedly increased. As a result of the component fractionation of the ginger juice, it was found that [6]-gingerol was a potent mutagen. However, the ginger juice also contained anti-mutagenic component(s) against [6]-gingerol (CAS No. 58253-27-3) (present study) and tryptophan pyrolysates (Kada et al., 1978; Morita et al., 1978). It is suggested, therefore, that the [6]-gingerol component may be mutagenically activated by the presence of AF2 and NTG.
D002396:Catechols; D003212:Condiments; D004305:Dose-Response Relationship, Drug; D004336:Drug Antagonism; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects; D005233:Fatty Alcohols / Q000494:pharmacology; D005668:Furylfuramide / Q000494:pharmacology; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D009152:Mutagenicity Tests; D009153:Mutagens / Q000037:antagonists & inhibitors; D009154:Mutation; D010936:Plant Extracts / Q000494:pharmacology*; D010944:Plants; D013045:Species Specificity
D002396:Catechols; D005233:Fatty Alcohols; D009153:Mutagens; D010936:Plant Extracts; D005668:Furylfuramide; D008769:Methylnitronitrosoguanidine; C007845:gingerol