[Toxicity and metabolism of acrylonitrile].
The paper presents the problem of occupational exposure to acrylonitrile vapours and toxic properties of this compound, as well as its metabolism in experimental animals, including its administration route. In addition, it deals with the mechanism of its toxic effects depending on the reactivity of the functional group of acrylonitrile particle. The authors discuss also the latest views on the capacity of acrylonitrile metabolites [S-(2-cyanoethyl)-mercapturic acid and rhodanates], depending on the route of acrylonitrile administration to rats.
D000181:Acrylonitrile / Q000378:metabolism / Q000633:toxicity*; D000393:Air Pollutants / Q000633:toxicity*; D000395:Air Pollutants, Occupational / Q000633:toxicity*; D000818:Animals; D001711:Biotransformation; D002617:Chemical Industry; D002940:Circadian Rhythm; D004285:Dogs; D006168:Guinea Pigs; D006207:Half-Life; D006801:Humans; D051379:Mice; D009570:Nitriles / Q000633:toxicity*; D011817:Rabbits; D013045:Species Specificity; D014835:Volatilization
D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D009570:Nitriles; D000181:Acrylonitrile
Toksyczność i metabolizm akrylonitrylu.