[The behavior of glucose tolerance, serum insulin and C-peptide in acute viral hepatitis].
On 35 patients with acute hepatitis had been carried out intravenous glucose-tolerance-tests (0,5 g glucose/kg). The assimilation coefficient of glucose and the level of insulin were determined during the acute phase of illness and the recovery phase. In 8 cases additionally C-peptide was determined to interpret the regulation of insulin-secretion and hepatic reduction. During the acute phase of illness the glucose-tolerance-test proofed 15 x clearly and 13 x limiting pathological. Except one patient all cases showed an improvement during recovery and 21 x a normalisation of glucose-tolerance. The serum-insulin-analysis gave 28 x lower figures during the acute phase compared to the healing-phase, whereas the determination of the C-peptide showed higher figures matching the enhanced glucose concentrations, which proves a normal regulation of insulin-secretion during the acute phase of disease in hepatitis. Because of the enhanced C-peptide/insulin-index our results support that in the early state of hepatitis the lower insulin figures are caused through a higher insulin clearance of the acute inflamed liver.
D000208:Acute Disease; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006509:Hepatitis B / Q000097:blood; D006525:Hepatitis, Viral, Human / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D010455:Peptides
Verhalten von Glukosetoleranz, Seruminsulin und C-Peptid im Verlauf einer akuten Virushepatitis.