title: Effect of chromium chloride supplementation on glucose tolerance and serum lipids including high-density lipoprotein of adult men.
abstract: Chromium deficiency may cause insulin resistance, hyperinsulinemia, impaired glucose tolerance, and hyperlipidemia, recovered by chromium supplementation. The effect of chromium supplementation on serum lipids and glucose tolerance was tested in a double-blind 12-wk study of 23 healthy adult men aged 31 to 60 yr. Either 200 micrograms trivalent chromium in 5 ml water (Cr) or 5 ml plain water (W) was ingested daily 5 days each week. Half the subjects volunteered for glucose tolerance tests with insulin levels. At 12 wk high-density lipoprotein cholesterol increased in the Cr group from 35 to 39 mg/dl (p less than 0.05) but did not change in the water group (34 mg/dl). The largest increase in high-density lipoprotein cholesterol and decreases in insulin and glucose were found in those subjects having normal glucose levels together with elevated insulin levels at base-line. The data are thus consistent with the hypothesis that Cr supplementation raises high-density lipoprotein cholesterol and improves insulin sensitivity in those with evidence of insulin resistance but normal glucose tolerance.
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D002712:Chlorides; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL; D002857:Chromium; D017608:Chromium Compounds; D004311:Double-Blind Method; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D007700:Kinetics; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D002712:Chlorides; D008076:Cholesterol, HDL; D017608:Chromium Compounds; D007328:Insulin; D008055:Lipids; D008075:Lipoproteins, HDL; D002857:Chromium; D002784:Cholesterol; C017133:chromous chloride