title: The effects of blood sera from calf fetuses in various periods of fetal life on skin allograft survival time in mice and on human lymphocyte proliferation in vitro.
abstract: The inhibitory effects of blood sera from calf fetuses in different periods of fetal life on human lymphocyte proliferation in short-term cultures and on the skin-allograft survival time in mice (C57Bl/6 leads to R3) were investigated. The lymphocytes mitosis inhibition and the decrease incorporation of [3H]thymidine into DNA of lymphocyte as well as the mouse skin-allograft survival-time prolongation were observed. It was found that the inhibiting activity of the sera decreased with the increase of age of the fetuses.
mesh_terms: D000367:Age Factors; D000818:Animals; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D005312:Fetal Blood; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008938:Mitosis / Q000187:drug effects; D011247:Pregnancy; D016038:Skin Transplantation; D014184:Transplantation, Homologous