[Role of the liver in the regulation of blood levels of insulin, C-peptide and glucose].
Insulin, C-peptide and glucose levels in the blood, collected from the portal, hepatic and femoral veins of 7 young healthy dogs were studied before and 3 to 45 minutes after intravenous glucose injection. It was found that insulin concentration in the peripheral vein does not reflect completely its secretion by pancreatic islets, since a considerable part of hormone, released after glucose injection, is retained by the liver. C-peptide concentration in the peripheral veins reflects more precisely the beta-cell secretory activity that insulin level. A rise of insulin concentration in the portal vein after intravenous glucose injection promotes the hepatic glucose assimilation.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood*; D004285:Dogs; D005947:Glucose / Q000378:metabolism*; D006503:Hepatic Veins; D007328:Insulin / Q000097:blood*; D008099:Liver / Q000378:metabolism*; D010455:Peptides / Q000097:blood*; D011169:Portal Vein
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D010455:Peptides; D005947:Glucose
Rol' pecheni v reguliatsii urovneĭ insulina, C-peptida i gliukozy v krovi.