Cyclosporin A hepatotoxicity in 66 renal allograft recipients.
Liver functional abnormalities were seen in 13 (19.7%) of 66 recipients of cadaveric renal homografts treated with cyclosporin A and prednisone. However, such presumed hepatotoxicity was a minor problem in the use of cyclosporin A. The complication was less frequent than that of nephrotoxicity, was as easily manageable with reductions in the cyclosporin A dosage, and generally did not cause clinical illness. In an occasional case, late hepatotoxicity can force a therapeutic change from cyclosporin A to azathioprine, but careful consideration should be given to the dangers of subsequent rejection.
D001379:Azathioprine / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology*; D003524:Cyclosporins / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006084:Graft Rejection / Q000187:drug effects; D006801:Humans; D016030:Kidney Transplantation; D008099:Liver / Q000503:physiopathology*; D008111:Liver Function Tests; D011241:Prednisone / Q000627:therapeutic use; D013997:Time Factors
D003524:Cyclosporins; D001379:Azathioprine; D011241:Prednisone