Aortic endothelium of alloxan diabetic rabbits: a quantitative study using scanning electron microscopy.
Scanning electron microscope studies of the aorta and other major arteries have been performed in alloxan-induced diabetic rabbits. After 5 weeks, a variety of structural abnormalities of the endothelial lining were detected including a significant increase in the number of argyrophilic cells and an increased number of craters or openings in the endothelial junctional region. Evidence of more extensive micro-damage was present after 5 months duration of diabetes. These zones with structural changes in the endothelial lining of major vessels seem to be areas of high predilection to atherosclerosis in diabetes.
D000818:Animals; D001011:Aorta / Q000648:ultrastructure*; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000473:pathology*; D004577:Electron Probe Microanalysis; D004727:Endothelium / Q000648:ultrastructure; D007328:Insulin / Q000627:therapeutic use; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D011817:Rabbits; D012834:Silver
D001786:Blood Glucose; D007328:Insulin; D012834:Silver