[Renal side effects of treatment with cyclosporin A in rheumatoid arthritis and after bone marrow transplantation].
Renal function was studied prospectively in 6 patients with rheumatoid arthritis and non-prospectively in 5 patients after bone marrow transplantation. Both groups were treated with cyclosporin A. Functionally and histologically the results suggest tubulotoxicity of cyclosporin A which seems to be dose-related and reversible. Also found in the urine of these patients were yellow, as yet undescribed crystalline bodies often included in casts.
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy*; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007669:Kidney Calculi / Q000139:chemically induced / Q000209:etiology; D007674:Kidney Diseases / Q000139:chemically induced / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000009:adverse effects*; D011446:Prospective Studies
D007166:Immunosuppressive Agents; D010456:Peptides, Cyclic
Renale Nebenwirkungen der Therapie mit Cyclosporin A bei chronischer Polyarthritis und nach Knochenmarktransplantation.