Effect of blood transfusions on canine renal allograft survival.
In this study significantly prolonged canine renal allograft survival has been demonstrated after transfusion of 100 ml of third-party whole blood given peroperatively. Peroperative transfusions of third-party leukocyte-free blood or pure lymphocyte cell suspensions did not influence graft survival. Furthermore, no improvement in graft survival has been found after a peroperative transfusion of irradiated whole blood (2500 rad). These data suggest that delayed graft rejection after blood transfusions can only be expected after the administration of whole blood. The role of competent lymphocytes in whole blood is questionable, since a transfusion or irradiated whole blood in combination with nonirradiated lymphocytes did not lead to prolonged graft survival. Immunosuppression of the recipient directly after transfusion seems to be essential to induce the beneficial effect of blood transfusions. This has been demonstrated for a transfusion of whole blood 14 days before transplantation. A single transfusion of 100 ml of whole blood 14 days before transplantation could effectively prolong graft survival if immunosuppression with azathioprine and prednisone was started on the day of transfusion. No improvement in graft survival has been found with such a transfusion if preoperative immunosuppression has been omitted.
D000818:Animals; D001379:Azathioprine / Q000627:therapeutic use; D001769:Blood / Q000528:radiation effects; D001803:Blood Transfusion; D002469:Cell Separation; D004285:Dogs; D005260:Female; D006085:Graft Survival / Q000187:drug effects / Q000528:radiation effects; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation; D007962:Leukocytes; D017710:Lymphocyte Transfusion; D008297:Male; D011241:Prednisone / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D001379:Azathioprine; D011241:Prednisone