Children of female renal transplant recipients.
Results of follow-up of 5 children, aged 4.5-9 years, who were born to kidney transplanted mothers are presented. Various immunological parameters were mainly within normal limits with the possible exception of 1 child who exhibited a granulocytopenia which normalized at about 5 years of age. Three children whose mothers were carriers of HBsAg during and after pregnancy have become antigen carriers and show slightly elevated levels of liver transferases. One child has a cardiac anomaly and signs of slight neurological dysfunction. In other respects the children are well and show normal psychomotor and somatic development. The rather sparse information from the literature regarding this group of children indicates a surprisingly low frequency of severe physical complications.
D000328:Adult; D002353:Carrier State / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000209:etiology; D006514:Hepatitis B Surface Antigens; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D016030:Kidney Transplantation; D011247:Pregnancy; D011248:Pregnancy Complications; D011297:Prenatal Exposure Delayed Effects; D012306:Risk
D006514:Hepatitis B Surface Antigens; D007136:Immunoglobulins