1,7-Dimethylguanosine formation in tRNA enzymatic methylation.
Data are reported showing that 1,7-dimethylguanosine is formed in tRNA enzymatic methylation and that the kidney extract exhibits a higher activity respect to the liver enzyme extract. In terms of relative percentages the amount of 1,7-dimethylguanosine produced by the kidney enzyme extract was three times higher than that produced by the liver extract. The possible importance of 1,7-dimethylguanosine in connection to chemical cancerogenesis by alkylating agents and to the aberrant increase of tRNA methylases activity in tumor tissues is advanced.
D000818:Animals; D004926:Escherichia coli; D006151:Guanosine / Q000031:analogs & derivatives* / Q000378:metabolism; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008745:Methylation; D012343:RNA, Transfer / Q000378:metabolism*; D051381:Rats; D012359:tRNA Methyltransferases / Q000378:metabolism*
D006151:Guanosine; C031003:1,7-dimethylguanosine; D012343:RNA, Transfer; D012359:tRNA Methyltransferases; C023196:tRNA (guanine(10)-N(2))-dimethyltransferase