[Insulin-heparin complex, its physiological properties].
An insulin-heparin complex was obtained in vitro. The hypoglycemic effect of insulin, included into this complex as compared with free insulin, was increased more than 2-fold when it was tested in animals with stable alloxane diabetes. Contrary to insulin, administration of the insulin-heparin complex increased the anticoagulation properties of blood and exhibited the non-enzymatic fibrinolytic activity towards the unstabilized fibrin both in presence or in absence of inhibitors of fibrinolysis, caused by plasmin.
D000496:Alloxan; D000818:Animals; D000925:Anticoagulants; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005342:Fibrinolysis / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology* / Q000627:therapeutic use; D007004:Hypoglycemic Agents; D007328:Insulin / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051381:Rats; D013056:Spectrophotometry, Ultraviolet
D000925:Anticoagulants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D000496:Alloxan; D006493:Heparin
Kompleks insulin-geparin, ego fiziologicheskie svoĭstva.