Effect of oral diazepam on lower oesophageal sphincter pressure.
The effect of diazepam 10 mg orally was investigated on lower oesophageal sphincter pressure in a random double-blind study of nine healthy volunteers. Barrier pressure decreased to a small but statistically significant extent. The reduction in barrier pressure was not related to the level of drowsiness.
D000284:Administration, Oral; D000328:Adult; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D004943:Esophagogastric Junction / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D011312:Pressure; D011897:Random Allocation
D003975:Diazepam