title: Hepatic vagotomy (partial hepatic denervation) does not alter ingestive responses to metabolic changes.
abstract: The effects of transecting the hepatic branch of the vagus nerve were studied in male and female Long Evans rats. No differences between same-sex hepatic vagotomized (HV) and sham operated (SHM) animals were found in postoperative body weight, diurnal patterns of ingestion, or the response to insulin (4, 8, 12 U/kg, IP), 2-deoxy-D-glucose (125, 250, 500 mg/kg, IP), sodium chloride (10 ml/kg: 0.5, 1.0, 2.0 M, IP), or polyethylene glycol (10 ml/kg: 30% w/v, SC). These results can be interpreted as evidence for a minor role of the hepatic vagus in the total complement of hepatic afferent innervation.
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D003847:Deoxyglucose; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D005260:Female; D007328:Insulin; D008099:Liver / Q000294:innervation*; D008297:Male; D011092:Polyethylene Glycols; D051381:Rats; D012737:Sex Factors; D012965:Sodium Chloride; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D007328:Insulin; D011092:Polyethylene Glycols; D012965:Sodium Chloride; D003847:Deoxyglucose