[Action of caffeine on the morphofunctional status of the pancreas and carbohydrate metabolic indices in white rats].
It has been shown that caffeine moderately increases the blood sugar content, which is related to the drug effect on the incretory apparatus of the pancreas. On being given in a dose of 25 mg/kg, caffeine increases the number of beta-cells in Langerhans islets while in a dose of 250 mg/kg it increases the size of the islets and raises the content of alpha-cells; the total amount of beta-cells remains essentially unchanged, but the number of beta-cells with low content of the insulin-like substance diminishes. Being given in large doses, caffeine activates the anaerobic phase of carbohydrate activation and causes a compensated respiratory metabolic acidosis.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D050260:Carbohydrate Metabolism; D004305:Dose-Response Relationship, Drug; D006019:Glycolysis / Q000187:drug effects; D007515:Islets of Langerhans / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats
D002110:Caffeine
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