title: [Selected double-blind comparative studies on the efficacy and tolerance of ciclopiroxolamine solution and cream].
abstract: The results of selected double-blind comparative studies, which had been conducted outside the Federal Republic of Germany, are reported on in summary. In these trials, a 1% solution of 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone, 2-aminoethanol salt (ciclopiroxolamine, Cic, Hoe 296, Batrafen) was compared with a 1% solution of tolnaftate (2 studies) and clotrimazole (1 study), respectively, and a 1% Cic cream was compared with a 1% clotrimazole cream (2 studies). The three compounds showed a similar efficacy against the respective groups of sensitive organisms. Particular characteristics and advantages of Cic which were observed with other modes of administration in studies conducted later on, had not been the objective of the trials reported here.
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D000077768:Ciclopirox; D002986:Clinical Trials as Topic; D003881:Dermatomycoses / Q000188:drug therapy*; D004311:Double-Blind Method; D004655:Emulsions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011728:Pyridones / Q000008:administration & dosage* / Q000009:adverse effects; D012996:Solutions; D014047:Tolnaftate / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D004655:Emulsions; D011728:Pyridones; D012996:Solutions; D014047:Tolnaftate; D000077768:Ciclopirox
vernacular_title: Ausgewählte Doppelblind-Vergleichsstudien zur Wirksamkeit und Verträglichkeit von Ciclopiroxolamin-Lösung und -Creme.