title: Cellular and molecular aspects of immune system aging.
abstract: We begin with a brief discussion of the importance and advantages of immune studies to the problem of aging. This is followed by a short over-view of immune system aging at the systemic level. The major portion of the article is a review of observation, both at the cellular and molecular level, of changes in aging immune cells, with sections on intercellular communication, membrane phenomena, cyclic nucleotides, and molecular genetic changes.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000502:physiology; D002450:Cell Communication; D002462:Cell Membrane / Q000276:immunology; D005260:Female; D006801:Humans; D007109:Immunity; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000378:metabolism; D008017:Life Expectancy; D008297:Male; D008875:Middle Aged; D008967:Molecular Biology; D009696:Nucleic Acids / Q000276:immunology; D009711:Nucleotides / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000502:physiology
chemical_list: D007136:Immunoglobulins; D009696:Nucleic Acids; D009711:Nucleotides