Influence of prostaglandins A1, E1, E2, and F2 alpha on renal blood flow and plasma renin activity. Investigations in chronically instrumented conscious dogs.
The effects of different prostaglandins (PG) on serial determination of renal blood flow (RBF), mean arterial blood pressure (MABP), renal vascular resistance (RVR) and renin release were investigated in the conscious, chronically instrumented dog. 2 months after right-sided nephrectomy, female beagle dogs (n = 6) were implanted with an electromagnetic flow probe and an inflatable pneumatic cuff around the left renal artery, and a catheter was inserted into the aorta above the renal artery. In repeated experiments, different prostaglandins (PGA1, E1, E2 and F2 alpha) were infused above the renal artery at increasing doses (infusion time 15 min, doses 0.03--1.0 micrograms min-1 kg-1). Lower and medium doses induced an increase of RBF, which returned to or were slightly below control levels with higher doses. PGA1 appeared to be the most potent vasodilator with a significant hypotensive activity and the greatest augmentation of RBF. Simultaneously, renin release was most pronounced by PGA1.
D000818:Animals; D001794:Blood Pressure; D015237:Dinoprost; D015232:Dinoprostone; D004285:Dogs; D005260:Female; D006339:Heart Rate; D007668:Kidney / Q000098:blood supply*; D011453:Prostaglandins / Q000494:pharmacology*; D011454:Prostaglandins A / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D012083:Renin / Q000097:blood*
D011453:Prostaglandins; D011454:Prostaglandins A; D011458:Prostaglandins E; D011460:Prostaglandins F; D015237:Dinoprost; D012083:Renin; D015232:Dinoprostone; C100573:prostaglandin A1