title: Peripheral vs central circulation times during CPR: a pilot study.
abstract: The circulation time during closed chest cardiac compression was studied using Cardio-Green injected in either the right antecubital vein or right subclavian vein during CPR. Arterial blood was obtained from a right femoral arterial catheter at 30-second intervals for five minutes following injection. Six patients, in two groups, comprised the study population. The arterial sample for Cardio-Green after central venous injection revealed a high concentration of the dye at 30 seconds and an emerging second peak at five minutes. After peripheral injection, no peak concentration of the dye was achieved during the five-minute sampling method. Our preliminary study indicates reduced concentrations and significant delay in arrival of injected agents that are introduced at a peripheral intravenous site during closed chest compression.
mesh_terms: D001776:Blood Circulation Time; D004395:Dye Dilution Technique; D006323:Heart Arrest / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007208:Indocyanine Green / Q000008:administration & dosage*; D007263:Infusions, Parenteral; D012151:Resuscitation; D013350:Subclavian Vein; D014680:Veins
chemical_list: D007208:Indocyanine Green