title: Amino acid sequence of rat alpha-lactalbumin: a unique alpha-lactalbumin.
abstract: The amino acid sequence of rat alpha-lactalbumin has been determined. Unlike other alpha-lactalbumins which contain 122 or 123 amino acids, rat alpha-lactalbumin is unique in that it contains 140 amino acids. The extra amino acids are a 17 amino acid extension at the carboxyl terminus. The amino acid sequence of this extension is Gly124-Ala-Pro-Ala-Leu-Val-Val130-Pro-Ala-Leu-Asp-Gly135-Glu-Thr-Pro-Val-Pro140 . The extension is proline rich, which may contribute to the anomalous structural properties of rat alpha-lactalbumin. The amino acid sequence from residues 1 to 123 is similar to that of other alpha-lactalbumins. One possible explanation for the 17 amino acid extension is a mutation at the termination codon.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D043424:Carboxypeptidase B; D002268:Carboxypeptidases; D003488:Cyanogen Bromide; D010450:Endopeptidases; D007768:Lactalbumin / Q000302:isolation & purification; D008666:Metalloendopeptidases; D010446:Peptide Fragments / Q000302:isolation & purification; D051381:Rats
chemical_list: D010446:Peptide Fragments; D007768:Lactalbumin; D002268:Carboxypeptidases; D010450:Endopeptidases; C022633:serine carboxypeptidase; D043424:Carboxypeptidase B; D008666:Metalloendopeptidases; C022653:auR protein, Staphylococcus aureus; C034735:arginine protease; D003488:Cyanogen Bromide