Does tryptophan potentiate clomipramine in the treatment of agoraphobic and social phobic patients?
A 10 week double blind study of 24 agoraphobics and 16 social phobics all on clomipramine compared the effect of adding tryptophan or placebo. Tryptophan did not potentiate the beneficial effect of clomipramine on phobic avoidance, phobic fears or the incidence of panic attacks. Neither was the presence of depression a factor of outcome.
D000328:Adult; D000379:Agoraphobia / Q000188:drug therapy; D002986:Clinical Trials as Topic; D002997:Clomipramine / Q000627:therapeutic use*; D004311:Double-Blind Method; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010698:Phobic Disorders / Q000188:drug therapy*; D011569:Psychiatric Status Rating Scales; D014364:Tryptophan / Q000627:therapeutic use*
D014364:Tryptophan; D002997:Clomipramine