title: Efficacy of using benzocaine for temporary relief of toothache.
abstract: The purpose of this investigation was to determine the efficacy of benzocaine for temporary relief of toothache. The agent used is available at drug counters; it contains 7.5 percent benzocaine in propylene glycol and has the form of a gel. The study was double blind. The agent and a placebo were provided by the manufacturer in an equal number of randomly numbered but otherwise unlabeled tubes. Forty-nine patients (twenty-five males and twenty-four females) with throbbing toothache pain resulting from dental caries were included in the study. The mean age was 25.6 years for patients receiving the drug and 26.7 years for patients receiving the placebo. Of the twenty-four patients who received the active agent, twenty (83 percent) were relieved of pain. The average time for onset of relief was 3.7 minutes. In the placebo group, only four patients (16 percent) were relieved of pain. When the chi-square test is used, the difference is statistically significant at the 0.01 level. No adverse reaction to the agents used was observed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001566:Benzocaine / Q000627:therapeutic use*; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003731:Dental Caries / Q000150:complications; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D014098:Toothache / Q000188:drug therapy* / Q000209:etiology
chemical_list: D010919:Placebos; D001566:Benzocaine