title: Circulating immune complexes after cadaver kidney transplantation.
abstract: 351 sera from 27 human recipients of renal allografts and 21 healthy blood donors were assayed for circulating immune complexes by the Clq solid-phase radioimmune assay. Increased Clq-binding activity (Clq-BA) was detected in pretransplant sera from 5 patients with chronic pyelonephritis (PN) and 3 patients with chronic glomerulonephritis (GN). A significant decrease of Clq-BA immediately after transplantation could not be found. 6 weeks after transplantation only 2 patients of the PN group showed increased Clq-BA. Serial studies in 17 patients with rejection crises did not show any correlation between the level of serum Clq-BA and the occurrence of rejections. Furthermore, no correlation could be found between the occurrence of complement-dependent lymphocytotoxic antibodies measured by the 51Cr release technique and the level of serum Clq-BA. In contrast, our results show that the probability of graftectomy or graft failure is significantly higher, at least in the early phase after transplantation, when the serum Clq-BA is lowered for several weeks.
mesh_terms: D000906:Antibodies; D000936:Antigen-Antibody Complex; D000961:Antilymphocyte Serum; D002102:Cadaver; D003166:Complement Activating Enzymes / Q000378:metabolism; D015922:Complement C1q; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology; D006084:Graft Rejection; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D011379:Prognosis; D011704:Pyelonephritis / Q000276:immunology
chemical_list: D000906:Antibodies; D000936:Antigen-Antibody Complex; D000961:Antilymphocyte Serum; D015922:Complement C1q; D003166:Complement Activating Enzymes