[Experiences with a chemically modified monospecies-insulin].
In a randomised clinical study 20 diabetics were given a des-phe-mixed-insulin. The quality of diabetes control was investigated. The average age of the patients was 53 years; the duration of the diabetes was 8.7 years in average. As criterion of diabetes control were accepted: a daily urinary excretion up to 10 g and a peak value of blood-sugar in the daily profile of 9.99 mmol/l (180 mg/dl). In 9 of the 20 patients the diabetes could be controlled easily by using des-phe-mixed-insulin. In the remaining 11 patients no sufficient control was achieved. These 11 patients were treated successfully within five days using a highly purified insulin from the pig (Mixtard). Compared to the des-phe-mixed-insulin the dose could be reduced by 26% in average. Two patients developed an allergy against the des-phe-mixed-insulin; one locally, one generalized.
D000293:Adolescent; D000328:Adult; D000368:Aged; D003920:Diabetes Mellitus / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007328:Insulin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
D007328:Insulin; C030808:insulin, (B1)-des-Phe-
Erfahrungen mit einem chemisch modifizierten Monospezies-Insulin.