A double-blind comparison of topical therapy of chlamydial ocular infection (TRIC infection) with rifampicin or chlortetracycline.
A double-blind stratified trial was carried out on 85 patients to assess the efficacy of topical therapy with 1% chlortetracycline eye ointment in comparison with 1% rifampicin eye ointment in the treatment of chlamydial ocular infection of sexually transmitted origin (paratrachoma). Patients included were selected on the basis of positive culture for Chlamydia trachomatis. A 6-week course of treatment with chlortetracycline or rifampicin 3 times daily gave a clinical cure rate of 80% and 75% and a microbiological cure rate of 93% and 86% respectively. In patients who were not cured the intensity of inflammatory responses was considerably reduced.
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D002690:Chlamydia Infections / Q000188:drug therapy*; D002692:Chlamydia trachomatis; D002751:Chlortetracycline / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003235:Conjunctivitis, Inclusion / Q000188:drug therapy; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007637:Keratoconjunctivitis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012293:Rifampin / Q000008:administration & dosage / Q000627:therapeutic use*; D014141:Trachoma / Q000188:drug therapy
D012293:Rifampin; D002751:Chlortetracycline