NA1, NA1, NA1-trimethylinsulin--an insulin analogue with a quaternary amino group at the A1 terminus.
By utilizing the differing reactivity of the amino groups in aqueous organic solvents, des-GlyA1-NB1,N epsilon B29-(Msc)2-insulin was prepared. Its reaction with the phenyl ester of N,N,N-trimethylglycine in the presence of N-hydroxysuccinimide afforded the crystalline NA1,NA1,NA1-trimethylinsulin analogue. In the fat cell assay this analogue has an activity of 49% and, in the mouse convulsion assay, it is 70%.
D000273:Adipose Tissue / Q000187:drug effects; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001681:Biological Assay; D002417:Cattle; D007202:Indicators and Reagents; D007328:Insulin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D008722:Methods; D011972:Receptor, Insulin / Q000378:metabolism
D000596:Amino Acids; D007202:Indicators and Reagents; D007328:Insulin; C031686:insulin, des-Gly(1A)-N-((trimethylammonio)acetyl)Ile(2A)-; D011972:Receptor, Insulin