Autoimmune encephalomyelitis: simultaneous identification of T and B cells in the target organ.
Monoclonal antibodies to guinea pig T cells and antibodies to guinea pig immunoglobulin G were used in immunofluorescence studies to identify T and B cells in central nervous system tissue from guinea pigs with acute autoimmune encephalomyelitis. T cells appeared before B cells and were distributed within the white matter parenchyma, while B cells remained in perivascular spaces.
D000818:Animals; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes / Q000276:immunology*; D001921:Brain / Q000276:immunology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D005456:Fluorescent Dyes; D006168:Guinea Pigs; D007074:Immunoglobulin G / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D005456:Fluorescent Dyes; D007074:Immunoglobulin G