title: Thyroid hormones and renin secretion.
abstract: Circulating angiotensin is produced by the action of renin from the kidneys on circulating angiotensinogen. There are other renin-angiotensin systems in various organs in the body, and recent observations raise the intriguing possibility that angiotensin II is produced by a totally intracellular pathway in the juxtaglomerular cells, the gonadotrops of the anterior pituitary, neurons, in the brain, salivary duct cells, and neuroblastoma cells. Circulating angiotensin II levels depend in large part on the plasma concentration of angiotensinogen, which is hormonally regulated, and on the rate of renin secretion. Renin secretion is regulated by an intrarenal baroreceptor mechanism, a macula densa mechanism, angiotensin II, vasopressin, and the sympathetic nervous system. The increase in renin secretion produced by sympathetic discharge is mediated for the most part by beta-adrenergic receptors, which are probably located on the juxtaglomerular cells. Hyperthyroidism would be expected to be associated with increased renin secretion in view of the increased beta-adrenergic activity in this condition, and hypothyroidism would be associated with decreased plasma renin activity due to decreased beta-adrenergic activity. Our recent research on serotonin-mediated increases in renin secretion that depend on the integrity of the dorsal raphe nucleus and the mediobasal hypothalamus has led us to investigate the effect of the pituitary on the renin response to p-chloroamphetamine. The response is potentiated immediately after hypophysectomy, but 22 days after the operation, it is abolished. This slowly developing decrease in responsiveness may be due to decreased thyroid function.
mesh_terms: D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D006801:Humans; D006980:Hyperthyroidism / Q000503:physiopathology; D007016:Hypophysectomy; D007668:Kidney / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood / Q000378:metabolism*; D013963:Thyroid Hormones / Q000502:physiology*; D010133:p-Chloroamphetamine / Q000494:pharmacology
chemical_list: D013963:Thyroid Hormones; D000804:Angiotensin II; D010133:p-Chloroamphetamine; D012083:Renin