Inducible expression of insulin receptors on T lymphocyte clones.
This study demonstrates that the insulin receptors are expressed on the surface of some T cell clones after specific antigenic stimulation. The insulin receptors on these lymphocytes are physicochemically similar to insulin receptors present on cells which express the receptors constitutively (adipocytes, hepatocytes, etc.). The kinetics of expression of insulin receptors on cloned, noncytotoxic T cells after specific antigenic stimulation closely parallels that of [3H]thymidine incorporation in such cultures.
D000818:Animals; D002460:Cell Line; D002999:Clone Cells; D003602:Cytotoxicity, Immunologic; D004261:DNA Replication; D007328:Insulin / Q000031:analogs & derivatives / Q000378:metabolism; D008213:Lymphocyte Activation; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D011972:Receptor, Insulin / Q000235:genetics*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*
D007328:Insulin; C008147:insulin, iodo-; D011972:Receptor, Insulin