title: [The use of artificial beta-cells or programmed insulin infusions in the therapy of insulin-dependent diabetes mellitus].
abstract: Completing the article 36, 19-26 (1981) of this journal, the indications for feedback-controlled ("closed-loop", artificial B-cell) and for glucose-independent ("open loop") insulin infusions are defined exactly. So far the artificial B-cell can be used as a bedside equipment only. Its application is restricted to a small number of diabetics who are difficult to be treated. In these cases, some improvement of insulin injection therapy can be obtained by means of so-called normoglycaemie intervening days and by the assessment of the "real" need of insulin using an artificial B-cell. Under certain conditions, open-loop insulin infusions seem to be advantageous both as continuous nocturnal basal rate administrations or as automated whole day infusions with the basal rates supplemented by extra doses to cover the meals. This should, however, be confirmed by controlled studies under ambulatory conditions.
mesh_terms: D003920:Diabetes Mellitus / Q000188:drug therapy*; D003926:Diabetic Coma / Q000188:drug therapy; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D007332:Insulin Infusion Systems
chemical_list: D007328:Insulin
vernacular_title: Zum Einstaz von künstlicher B-Zelle oder programmierten Insulininfusionen in der Therapie des insulinpflichtigen Diabetes mellitus.