title: [Study of the interrelations of ethmozine, cordarone and phenycaberan with heparin].
abstract: Cordarone, etmozin and phenycaberan form complexes with heparin. Etmozin and phenycaberan form complexes insoluble in an aqueous medium and exhibit a pronounced antiheparin action in in-vitro experiments. Cordarone and heparin form a complex which is soluble in an aqueous medium. This complex potentiates the biological activity of the anticoagulant. In experiments on rabbits cordarone and phenycaberan increase plasma tolerance to heparin followed by its lowering as compared with controls in experiments with phenycaberan. Etmozin decreases plasma tolerance to heparin.
mesh_terms: D000638:Amiodarone / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001572:Benzofurans / Q000494:pharmacology; D004285:Dogs; D004347:Drug Interactions; D004357:Drug Synergism; D006493:Heparin / Q000494:pharmacology; D006494:Heparin Antagonists / Q000494:pharmacology; D066298:In Vitro Techniques; D016293:Moricizine; D009025:Morpholines / Q000494:pharmacology; D010640:Phenothiazines / Q000494:pharmacology; D011817:Rabbits
chemical_list: D000889:Anti-Arrhythmia Agents; D001572:Benzofurans; D006494:Heparin Antagonists; D009025:Morpholines; D010640:Phenothiazines; D016293:Moricizine; C015212:fenicoberan; D006493:Heparin; D000638:Amiodarone
vernacular_title: Issledovanie vzaimootnosheniĭ étmozina, kordarona i fenikaberana s geparinom.