[Ultrastructural peroxidases and immunological markers in acute adult leukaemia: therapeutic applications (author's transl)].
In a retrospective study of 112 adult patients with acute leukaemia (AL), the percentage of undifferentiated leukaemia was reduced to almost 1% by an analysis of routine cytochemical reactions (PAS, peroxidase, esterases and esterase inhibition), B and T lymphocyte markers (IgS, E-rosettes, HuTLA) cAll antigen and ultrastructural detection of peroxidase activity (PO-ME). A simultaneous study of cALL antigen and PO-ME showed reciprocal exclusion of these markers, except in one case of mixed leukaemia. Therapeutically, the value of these tests lies in that patients with typical PAS reaction and cALL antigen consistently respond to vincristine- corticosteroid treatment, whereas patients without cALL and with PO-ME are frequently resistant to that combination of drugs.
D000328:Adult; D003584:Cytological Techniques; D006651:Histocytochemistry; D006801:Humans; D007945:Leukemia, Lymphoid / Q000145:classification* / Q000276:immunology / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000145:classification* / Q000276:immunology / Q000628:therapy; D010544:Peroxidases / Q000032:analysis*; D011241:Prednisone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D014750:Vincristine; D010544:Peroxidases; D011241:Prednisone
Peroxydases ultrastructurales et marqueurs immunologiques dans les leucémies aiguës de l'adulte: incidence thérapeutique.