title: Involvement of prostaglandin E1 in delayed-type hypersensitivity suppression induced with live Mycobacterium bovis BCG.
abstract: We previously showed the suppression of delayed-type hypersensitivity produced by live BCG-induced, plastic-adhering cells. The present study was undertaken to determine whether prostaglandin was one of the pharmacological mediators involved in this suppression. A high level of prostaglandin E1 was detected in the culture supernatant fluid of the live BCG-induced, adherent cells. Moreover, prostaglandin E1 could suppress the macrophage migration inhibition activity of peritoneal exudate cells from BCG cell wall-sensitized mice.
mesh_terms: D000527:Alprostadil; D000818:Animals; D002464:Cell Migration Inhibition; D006968:Hypersensitivity, Delayed; D007213:Indomethacin / Q000494:pharmacology; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009163:Mycobacterium bovis / Q000276:immunology*; D011458:Prostaglandins E / Q000502:physiology*
chemical_list: D011458:Prostaglandins E; D000527:Alprostadil; D007213:Indomethacin