Short-term antibiotic prophylaxis and prostatectomy.
Two hundred patients undergoing prostatic surgery at 2 hospitals were randomly allocated into 4 equal groups. The groups were a control, cephalexin, co-trimoxazole and carfecillin treated groups. The incidence of urinary tract infections and other complications of prostatic surgery were studied in each group after a short-term prophylactic regime of 3 doses of the antibiotic. The incidence of urinary infection was significantly improved from 28% in the control group to 8% and 16% in the co-trimoxazole and cephalexin groups respectively. Carfecillin was not effective in reducing urinary infection. However, all 3 antibiotics reduced the incidence of other infective sequelae.
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002323:Carfecillin / Q000627:therapeutic use; D002506:Cephalexin / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004338:Drug Combinations / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D011292:Premedication; D011468:Prostatectomy; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014552:Urinary Tract Infections / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D002323:Carfecillin; D014295:Trimethoprim; D013420:Sulfamethoxazole; D002506:Cephalexin