Mutagenicity studies with o-tolidine and 4,4'-tetramethyldiaminodiphenylmethane.
This paper confirms the mutagenicity of 2 carcinogenic chemicals, o-tolidine and 4,4'-tetramethyldiaminodiphenylmethane (TDDM). o-Tolidine and TDDM were both tested in the Salmonella/mammalian-microsome test and in the sister-chromatid exchange (SCE) test with rabbit lymphocytes in vitro. The number of revertants was increased in the presence of S9 mix by o-tolidine in the Salmonella typhimurium strains TA98 and TA1538, and by TDDM in strains TA98 and TA100. Both compounds showed weak SCE-inducing activity in cultured rabbit lymphocytes in the absence, but not in the presence, of an exogenous metabolic system.
D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D001560:Benzidines / Q000494:pharmacology*; D008214:Lymphocytes / Q000648:ultrastructure; D009152:Mutagenicity Tests; D009153:Mutagens; D011817:Rabbits; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics; D012854:Sister Chromatid Exchange
D000814:Aniline Compounds; D001559:Benzhydryl Compounds; D001560:Benzidines; D009153:Mutagens; C009501:2-tolidine; C035472:N,N,N',N'-tetramethyl-4,4'-methylenedianiline