title: Controlled comparison of nalidixic acid or lactulose with placebo in shigellosis.
abstract: Nalidixic acid and lactulose, respectively, were compared with placebo in a controlled double-blind study in 43 patients with bacteriologically verified shigellosis. All the strains were susceptible to nalidixic acid. Treatment with nalidixic acid resulted in cure in 72%, which was a significantly better result than with placebo (cure in 21%).
mesh_terms: D002986:Clinical Trials as Topic; D004187:Disaccharides / Q000627:therapeutic use*; D004311:Double-Blind Method; D004405:Dysentery, Bacillary / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007792:Lactulose / Q000494:pharmacology / Q000627:therapeutic use*; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D004187:Disaccharides; D009268:Nalidixic Acid; D007792:Lactulose