Innervation of rat antral gastrin-producing cells.
The innervation of rat antral gastrin-producing cells (G-cells) was studied by light and electron microscopy. Combination of histochemistry for acetylcholinesterase and immunofluorescence for gastrin in the same tissue section showed apparent contact between some of the G-cells and acetylcholinesterase-positive nerves. Electron microscopic observation, however, revealed gaps of 200-500 nm or more between the G-cells and the closest nerve axons which often contained large dense-cored vesicles. The latter may represent the storage sites for neuropeptides previously localized by immunohistochemistry in gastric nerves.
D000110:Acetylcholinesterase / Q000032:analysis; D000818:Animals; D002799:Cholinergic Fibers / Q000201:enzymology / Q000648:ultrastructure*; D005455:Fluorescent Antibody Technique; D005753:Gastric Mucosa / Q000294:innervation* / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism*; D008854:Microscopy, Electron; D011706:Pyloric Antrum / Q000294:innervation*; D051381:Rats
D005755:Gastrins; D000110:Acetylcholinesterase