Isolation of N-(2,6-diamino-6-hydroxymethylpimelyl)-L-alanine from Micromonospora chalcea.
A novel dipeptide, N-(2,6-diamino-6-hydroxymethylpimelyl)-L-alanine, was isolated from the culture broth of a microorganism identified as Micromonospora chalcea. The dipeptide exhibits antimicrobial activity against Escherichia coli on a synthetic medium, and the activity is synergistically enhanced by several cell wall synthesis-inhibitors.
D000599:Amino Acids, Diamino / Q000302:isolation & purification*; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D003960:Diaminopimelic Acid / Q000031:analogs & derivatives / Q000302:isolation & purification* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D008847:Micromonospora / Q000032:analysis* / Q000145:classification; D009842:Oligopeptides / Q000302:isolation & purification* / Q000494:pharmacology
D000599:Amino Acids, Diamino; D000900:Anti-Bacterial Agents; D009842:Oligopeptides; D003960:Diaminopimelic Acid; C031768:N-(2,6-diamino-6-hydroxymethylpimelyl)alanine