Effect of Leucogenenol on recovery from immunosuppressin by anti-lymphocyte globulins.
Daily treatment of rats with the thymothyroid hormone leucogenenol after their immunosuppression with anti-lymphocyte globulins causes the rats to regain their immunocompetency after 7 days of treatment, in contrast to well over a month, which is required for untreated controls. Immunocompetency was mesured by the ability of the rat to respond to the injection of sheep erythrocytes with the formation of normal concentrations of antibody-forming cells in their lymphoid tissues and normal titers of hemolysins in their serum. These results indicate that leucogenenol increases the rate of development of T cells, as well as B cells, from committed precursors.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D000961:Antilymphocyte Serum / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000276:immunology; D006460:Hemolysin Proteins; D006462:Hemolytic Plaque Technique; D007165:Immunosuppression Therapy; D007932:Leucogenenol / Q000627:therapeutic use*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012756:Sheep; D013141:Spiro Compounds / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000276:immunology
D000961:Antilymphocyte Serum; D006460:Hemolysin Proteins; D013141:Spiro Compounds; D007932:Leucogenenol