The anaerobe-mediated mutagenicity of 2-nitrofluorene and 2-aminofluorene for Salmonella typhimurium.
Anaerobic bacteria (Bacteroides fragilis, B vulgatus, and B thetaiotaomicron) possess the enzymic ability to convert 2-nitrofluorene and 2-aminofluorene to substances mutagenic for Salmonella typhimurium. If it be assumed that the active intermediate for both chemicals is 2-hydroxylaminofluorene, then these bacteria possess reductive as well as oxidative capabilities.
D000693:Anaerobiosis; D001439:Bacteroides / Q000378:metabolism*; D001711:Biotransformation; D005449:Fluorenes / Q000378:metabolism* / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009154:Mutation; D010084:Oxidation-Reduction; D012486:Salmonella typhimurium / Q000235:genetics*
D005449:Fluorenes; C019499:2-nitrofluorene; C012177:2-aminofluorene