A comparison of sustained-release terbutaline and ordinary terbutaline in bronchial asthma.
The effects and side effects in steady state of a sustained-release preparation of terbutaline 7.5 mg twice daily were compared with ordinary tablets 5 mg three times daily. The study performed for two weeks was double-blind, double-dummy, cross-over with randomized allocation of the drugs. 20 patients completed the trial and the results show higher mean morning PEFR values and a tendency to milder side effects with depot tablets.
D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate; D011897:Random Allocation; D013726:Terbutaline / Q000627:therapeutic use*
D003692:Delayed-Action Preparations; D013726:Terbutaline