Thymopoietin in rheumatoid arthritis.
In a controlled study involving 36 patients, thymopoietin was shown to be more effective than levamisole and as effective as penicillamine in improving the clinical status of patients with rheumatoid arthritis. There were small reductions in erythrocyte sedimentation rate and IgG which did not achieve statistical significance. Rheumatoid factor titre did not change. Although its mechanism of action is almost certainly related to its immunomodulatory properties it does not seem to be the same as that of levamisole.
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001799:Blood Sedimentation; D002986:Clinical Trials as Topic; D006801:Humans; D007978:Levamisole / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy; D010396:Penicillamine / Q000009:adverse effects / Q000627:therapeutic use; D013946:Thymopoietins / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use*; D013951:Thymus Hormones / Q000627:therapeutic use*
D013946:Thymopoietins; D013951:Thymus Hormones; D007978:Levamisole; D010396:Penicillamine