Effects of buflomedil on erythrocyte deformability.
This brief communication outlines recent experiments on the effects of buflomedil, a new vasoactive agent, on red cell deformability in patients with leg ischemia. In this randomized, double-blind-cross-over study, 10 patients received 200 mg buflomedil and matching placebo intravenously. Red cell filterabiltiy in these patients was significantly improved after buflomedil administration versus baseline values with no significant change in filterability versus baseline after placebo administration.
D002986:Clinical Trials as Topic; D004913:Erythrocytes, Abnormal / Q000187:drug effects*; D006801:Humans; D007511:Ischemia / Q000188:drug therapy; D007866:Leg / Q000098:blood supply; D008851:Micropore Filters; D011759:Pyrrolidines / Q000627:therapeutic use*
D011759:Pyrrolidines; C010651:buflomedil