Studies on mutagenic and carcinogenic N-substituted aryl compounds: cosmetics and drugs.
We aimed our studies toward gaining an understanding of some of the reactions and pathways involved in the metabolism and activation of the aromatic diamines used in hair dyes and of phenacetin used in analgesic mixtures. Comparison of the data obtained from human and animal tissues established that animal tissues can serve as suitable models for evaluation of the activity of these compounds in humans.
D000328:Adult; D000818:Animals; D001711:Biotransformation; D002273:Carcinogens; D006224:Cricetinae; D003959:Diamines / Q000009:adverse effects*; D004353:Drug Evaluation, Preclinical; D005260:Female; D006202:Hair Dyes / Q000009:adverse effects*; D006203:Hair Preparations / Q000009:adverse effects*; D006801:Humans; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D009153:Mutagens; D009154:Mutation; D009369:Neoplasms / Q000139:chemically induced*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010615:Phenacetin / Q000009:adverse effects*; D011817:Rabbits; D051381:Rats; D012449:Safety; D012486:Salmonella typhimurium / Q000187:drug effects
D002273:Carcinogens; D003959:Diamines; D006202:Hair Dyes; D006203:Hair Preparations; D009153:Mutagens; D010615:Phenacetin