title: Is cell aging caused by respiration-dependent injury to the mitochondrial genome?
abstract: Though intrinsic mitochondrial aging has been considered before as a possible cause of cellular senescence, the mechanisms of such mitochondrial aging have remained obscure. In this article we expand on our hypothesis of free-radical-induced inhibition of mitochondrial replenishment in fixed postmitotic cells. We maintain that the respiration-dependent production of superoxide and hydroxyl radicals may not be fully counteracted, leading to a continuous production of lipoperoxides and malonaldehyde in actively respiring mitochondria. These compounds, in turn, can easily react with the mitochondrial DNA which is in close spatial relationship with the inner mitochondrial membrane, producing an injury that the mitochondria may be unable to counteract because of their apparent lack of adequate repair mechanisms. Mitochondrial division may thus be inhibited leading to age-related reduction of mitochondrial numbers, a deficit in energy production with a concomitant decrease in protein synthesis, deterioration of physiological performance, and therefore, of organismic performance.
mesh_terms: D000818:Animals; D002470:Cell Survival; D004272:DNA, Mitochondrial / Q000502:physiology*; D005609:Free Radicals; D008054:Lipid Peroxides / Q000502:physiology; D008315:Malondialdehyde; D010101:Oxygen Consumption
chemical_list: D004272:DNA, Mitochondrial; D005609:Free Radicals; D008054:Lipid Peroxides; D008315:Malondialdehyde