Forearm insulin uptake in healthy subjects after oral glucose and intravenous glipizide.
In six healthy subjects fasted overnight two different experiments were carried out on separate days and in random order: A. Oral glucose followed 60 min later by iv glipizide. B. Iv glipizide followed 60 min later by oral glucose. Each experiment was divided into two 60 min periods, and the fractionated insulin uptake by forearm tissue was calculated for each 60 min period. When the fractional insulin uptake values for these four 60 min periods were compared it was found that the uptake of insulin was significantly higher for the 60 min period that was obtained in response to glucose without glipizide pre-treatment, than it was for any of the other 60 min periods. Moreover, in some of the participants the venous insulin concentration occasionally exceeded the corresponding arterial insulin concentration after iv glipizide administration. These findings imply that glipizide may decrease insulin binding to peripheral insulin receptors in healthy individuals.
D000284:Administration, Oral; D000328:Adult; D005260:Female; D005542:Forearm / Q000098:blood supply; D005913:Glipizide / Q000008:administration & dosage / Q000494:pharmacology*; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D008297:Male; D013453:Sulfonylurea Compounds / Q000494:pharmacology*; D013997:Time Factors
D007328:Insulin; D013453:Sulfonylurea Compounds; D005947:Glucose; D005913:Glipizide