Jarisch-Herxheimer reaction in complement-depleted rabbits. Histological and immunofluorescence studies of early cutaneous lesions.
The possible role of complement in the pathogenesis of the Jarisch-Herxheimer reaction was assessed in cutaneous syphilitic lesions in two groups of rabbits treated with penicillin; in one group complement was depleted before penicillin therapy. Serial biopsy specimens were similar histologically in both groups. The activation of the complement pathways did not seem to play a role in the pathogenesis of early cutaneous syphilitic lesions in rabbits during the Jarisch-Herxheimer reaction.
D000818:Animals; D003167:Complement Activation; D003165:Complement System Proteins / Q000276:immunology* / Q000502:physiology*; D005455:Fluorescent Antibody Technique; D009504:Neutrophils / Q000473:pathology; D010402:Penicillin G Procaine / Q000627:therapeutic use*; D011817:Rabbits; D012867:Skin / Q000473:pathology; D013591:Syphilis, Cutaneous / Q000188:drug therapy / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*
D010402:Penicillin G Procaine; D003165:Complement System Proteins