Transplantation of lymphoid cells in patients with severe combined immunodeficiency (SCID).
The effects of bone marrow or fetal lymphoid organ transplants in 15 patients with severe combined immunodeficiency disease are reported. The benefits and dangers inherent to the various transplantation strategies are discussed. Our studies indicate that, even in the group of patients with B cells, bone marrow transplantation may be the best procedure to obtain the reconstitution of cellular and humoral functions.
D001402:B-Lymphocytes / Q000276:immunology; D016026:Bone Marrow Transplantation; D005260:Female; D005333:Fetus / Q000033:anatomy & histology; D006085:Graft Survival; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000628:therapy*; D007223:Infant; D016031:Liver Transplantation; D008211:Lymphocyte Cooperation; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000637:transplantation*; D014184:Transplantation, Homologous