Starvation-induced ketone body production in the conscious unrestrained miniature pig.
The effects of short-term starvation (up to 5 days) on hepatic ketone body production was investigated in the conscious unrestrained miniature pig in vivo. Starvation induced an increase in arterial free fatty acid concentration (0.2-0.7 mM) with a concomitant elevation in hepatic free fatty acid extraction [-1.4-5.7 mumol/kg. minute),r = 0.53, P less than 0.005]. Ketone body production (sum of acetoacetate + beta-hydroxybutyrate) increased from 1.5 to 5.8 mumol/(kg . minute) in parallel (r = 0.71, P less than 0.0005). During starvation arterial insulin levels decreased, glucagon increased, cortisol remained unchanged and a "low T3 state' was observed. These data differ in some aspects from those reported for humans and dogs. Thus a species-specific variation in the fuel economy of the pig's body is proposed.
D000818:Animals; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005934:Glucagon / Q000097:blood; D007328:Insulin / Q000097:blood; D007657:Ketone Bodies / Q000096:biosynthesis*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D013217:Starvation / Q000378:metabolism*; D013552:Swine / Q000378:metabolism*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014285:Triiodothyronine, Reverse / Q000097:blood
D005230:Fatty Acids, Nonesterified; D007328:Insulin; D007657:Ketone Bodies; D014284:Triiodothyronine; D014285:Triiodothyronine, Reverse; D005934:Glucagon; D013974:Thyroxine