Indoprofen. Short-term double-blind cross-over study in patients with osteoarthritis of the hip.
A comparison was made between indoprofen (800 mg/day), naproxen (500 mg/day) and placebo in 30 patients with well defined osteoarthritis of the hip. Treatments were given for 10 days each, according to a double-blind, cross-over design. Objective and subjective criteria were adopted for evaluation of effectiveness. Special attention was paid to side effects. There was a marked difference between the active drugs and placebo. Indoprofen was significantly better than naproxen on many variables, and was, in most cases, preferred to the latter, by patients and investigator.
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D004064:Digestive System / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006621:Hip Joint; D006801:Humans; D007216:Indoprofen / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000008:administration & dosage*; D010003:Osteoarthritis / Q000188:drug therapy*; D010666:Phenylpropionates / Q000008:administration & dosage*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010666:Phenylpropionates; D009288:Naproxen; D007216:Indoprofen