A case of membranous glomerulonephritis in which positive to negative change of hepatitis B e antigen in glomeruli was observed.
9-year-old boy suffering from membranous glomerulonephritis (GN) associated with hepatitis B virus (HBV) infection was observed. In this case seroconversion from hepatitis B e antigen (HBeAg) to hepatitis B e antibody (HBeAb) could not be confirmed, but a change from HBeAg positive to negative in the glomeruli was observed, and electron-dense deposits (EDD) became translucent and urinary protein also turned negative. These findings apparently suggest the possibility that membranous GN in this case is closely concerned with the causation and development of HBeAg.
D002648:Child; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D006510:Hepatitis B Antibodies / Q000032:analysis; D006511:Hepatitis B Antigens / Q000032:analysis*; D006513:Hepatitis B e Antigens / Q000032:analysis*; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology*; D008297:Male; D008854:Microscopy, Electron
D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens; D006513:Hepatitis B e Antigens