Preliminary chemical and biologic characterization of (Fc)TRF: an Fc fragment-induced T cell-replacing factor.
Fc fragment stimulation of Lyt-1+2- T lymphocytes triggers release of a T cell-replacing factor, here called (Fc)TRF. Chemical and biologic characterization of (Fc)TRF has been undertaken to provide information for its comparison with other T cell factors. Preliminary chemical characterization by column chromatography and isoelectric focusing suggest (Fc)TRF activity resides in a class of acidic molecules that fall into two size classes of 58-60,000 daltons and 35-40,000 daltons. This factor is distinct from Interleukin 2 (IL 2) as it has no T cell growth-promoting or costimulator activity, although it can also be generated by Con A activation of murine spleen cells. By these results (Fc)TRF has been defined as a unique T cell-replacing activity that promotes differentiation of B lymphocytes to antibody-secreting cells.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D055598:Chemical Phenomena; D002621:Chemistry; D006462:Hemolytic Plaque Technique; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000276:immunology*; D015848:Interleukin-5; D008222:Lymphokines / Q000096:biosynthesis / Q000276:immunology* / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D008970:Molecular Weight; D011817:Rabbits; D013601:T-Lymphocytes / Q000276:immunology
D007141:Immunoglobulin Fc Fragments; D015848:Interleukin-5; D008222:Lymphokines