title: [Studies about combined lesions - 30th communication. Activation and inhibition of blood-coagulation after whole-body irradiation combined with trauma (author's transl)].
abstract: 45 rabbits of both sexes were divided into five groups. Animals were sham irradiated, inflicted with an autologous haematoma as a trauma, whole-body irradiated with 500 RX-rays, and inflicted with a combination of irradiation and autologous haematoma or skin-wound. Already 24 hr after irradiation a highly significant prolongation of the activated partial thromboplastin-time was observed. The concentrations of factor X and fibrinogen increased in all irradiated animals 24 hr after irradiation. Following the combination injury of irradiation and skin-wound such increases were significantly higher than those after irradiation alone. The activities of antithrombin III and antiplasmin, measure with chromogen substrates, rose after irradiation as well as after combined injuries. In spite of the increased level of fibrinogen we could register hypocoagulability with significant increase of activation as well as of inhibition of the plasmatic coagulation system 24 hr after combined injuries.
mesh_terms: D000818:Animals; D000990:Antithrombin III / Q000032:analysis; D001777:Blood Coagulation / Q000528:radiation effects*; D001778:Blood Coagulation Disorders / Q000209:etiology*; D005170:Factor X / Q000032:analysis; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D008297:Male; D011817:Rabbits; D011829:Radiation Dosage; D014916:Whole-Body Irradiation; D014947:Wounds and Injuries / Q000097:blood*; D000979:alpha-2-Antiplasmin / Q000032:analysis
chemical_list: D000979:alpha-2-Antiplasmin; D000990:Antithrombin III; D005170:Factor X; D005340:Fibrinogen
vernacular_title: Untersuchungen über Kombinationsschäden. 30. Mitteilung. Aktivierung und Inhibition der Blutgerinnung nach Ganzkörperbestrahlung in Kombination mit einem Trauma.