Luteinizing hormone-releasing factor increases release of human chorionic gonadotrophin in isolated cell columns of normal and malignant trophoblasts.
The effect of synthetic luteinizing hormone-releasing factor (LRF) on release of human chorionic gonadotrophin (hCG) was studied by isolated cell columns of normal syncytiotrophoblasts and choriocarcinoma (BeWo) cells. After LRF stimulation the release of hCG by the normal trophoblasts increased up to 4-fold and release by the malignant trophoblasts increased up to 6-fold, indicating a specific effect of LRF on normal and malignant trophoblast cells.
D002469:Cell Separation; D002470:Cell Survival; D002478:Cells, Cultured; D002822:Choriocarcinoma / Q000378:metabolism*; D006063:Chorionic Gonadotropin / Q000378:metabolism*; D002850:Chromatography, Gel; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D011247:Pregnancy; D011863:Radioimmunoassay; D014327:Trophoblasts / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000378:metabolism*
D006063:Chorionic Gonadotropin; D007987:Gonadotropin-Releasing Hormone