Cells mediating graft rejection in the mouse. III. Ly-1+ precursor T cells generate skin graft rejection.
Skin graft rejection in ATXBM CBA mice reconstituted with naive (nonsensitized) cells was shown to be mediated predominantly by Ly-1+2- effector T cells. Thus, after the treatment of the inoculum with the monoclonal anti-Ly-1.1 antibody and complement, C57BL/6 skin grafts survived indefinitely, whereas Ly-2 antibody depletion merely delayed the onset of rejection. This showed that a Ly-1+2- precursor cell rather than a Ly-1+2+ cell was the progenitor of the Ly-1+2- graft rejection effector cell. Nevertheless, another T cell subset augmented the rejection of ski grafts and it was concluded that LY-1,2,3+ cells also provided a pool of precursor cells. Thus, it appeared that both Ly-1+ and Ly-1,2,3+ cells can function as precursor cells for the effector cells, which, as shown previously, have the ly-1+ phenotype.
D000818:Animals; D000950:Antigens, Ly; D002454:Cell Differentiation; D004306:Dose-Response Relationship, Immunologic; D006084:Graft Rejection; D007111:Immunity, Cellular; D007116:Immunization, Passive; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D016038:Skin Transplantation; D013601:T-Lymphocytes / Q000145:classification / Q000166:cytology / Q000276:immunology*
D000950:Antigens, Ly