title: Nonspecific enhancement of resistance to local bacterial infection in starved mice.
abstract: We studied the effect of muramyl dipeptide (MDP) on enhancing resistance to local bacterial challenge in starved mice. The challenge consisted of the intramuscular insertion of a suture laden with Klebsiella pneumoniae. Mice that had been pretreated with MDP had a statistically lower rate of bacterial recovery at the site of the challenge, had consistently fewer bacteria in the blood, and had improved short-term survival. By enhancing local bacterial containment, MDP pretreatment of immunocompromised animals reduces the level of bacteremia and subsequent mortality.
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D000818:Animals; D001424:Bacterial Infections / Q000276:immunology*; D005508:Food Deprivation; D006020:Glycopeptides / Q000494:pharmacology*; D007113:Immunity, Innate / Q000187:drug effects; D007710:Klebsiella Infections / Q000276:immunology; D007711:Klebsiella pneumoniae; D008297:Male; D051379:Mice; D018805:Sepsis / Q000276:immunology
chemical_list: D006020:Glycopeptides; D000119:Acetylmuramyl-Alanyl-Isoglutamine