title: Effects of a low-salt diet and of acute salt loading on blood pressure and intralymphocytic sodium concentration in young subjects with borderline hypertension.
abstract: 1. Three groups of young patients with borderline hypertension were studied for a 12 months period. The first was on a free sodium diet while the second was on a low-salt diet. The third group of patients underwent acute salt loading. 2. After 12 months the group on free diet showed a significant increase of intralymphocytic sodium but no change in blood pressure was noted. Five patients who were re-checked after 24 months also had a significant increase in blood pressure. 3. Patients treated with a low-salt diet showed a significant decrease of both intralymphocytic sodium concentration and blood pressure. 4. After acute salt loading, borderline subjects with high intralymphocytic sodium showed a significant greater natriuresis whereas intralymphocytic sodium increased only in those subjects in whom it was initially normal.
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004039:Diet, Sodium-Restricted; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000178:diet therapy; D008214:Lymphocytes / Q000378:metabolism; D012083:Renin / Q000097:blood; D012964:Sodium / Q000097:blood*; D012965:Sodium Chloride / Q000009:adverse effects*
chemical_list: D012965:Sodium Chloride; D012964:Sodium; D012083:Renin