title: Controlled clinical trial of a new non-calorigenic sweetening agent.
abstract: In a controlled trial of a double-blind cross-over design, it has been shown that "Marvie', a non-calorigenic sweetener containing 58 per cent maltitol by weight, is an effective sweetener which has no influence on routine haematological and biochemical parameters. The dose that could be tolerated without undesirable symptoms was between 20 and 30 g per day. Above this dose, flatus production with abdominal discomfort could limit tolerance to this sweetening agent.
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D003967:Diarrhea / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004361:Drug Tolerance; D005414:Flatulence / Q000139:chemically induced; D006403:Hematologic Tests; D006801:Humans; D008320:Maltose / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D010919:Placebos; D013402:Sugar Alcohols / Q000008:administration & dosage / Q000009:adverse effects*; D013549:Sweetening Agents / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D010919:Placebos; D013402:Sugar Alcohols; D013549:Sweetening Agents; D008320:Maltose; C010745:maltitol