Enflurane anesthesia in living donor renal transplantation.
Two groups of patients undergoing elective living donor renal transplantation were studied during enflurane or halothane supplemented anesthesia. The duration of anesthesia was similar in both groups. The mean administered enflurane dose was 243 vol % min; the corresponding halothane dose was 56 vol % min. In the enflurane group, the mean serum inorganic fluoride level peaked at 21.0 mumol/l 3 h after the end of anesthesia. The inorganic fluoride level in urine produced by the renal graft increased continuously, but did not peak, during the first 24 postanesthetic hours. The renal graft quickly started to function in all patients in both groups. The frequency of rejection reactions was higher in the enflurane group than in the halothane group. Serum creatinine levels decreased rapidly in both groups. Urine flow was high on the day of transplantation, but normalized on the first postanesthetic day. Renal sodium clearance decreased earlier in the enflurane group than in the halothane group. This difference was statistically significant on the first postanesthetic day. In the enflurane group, the required pancuronium dose was significantly lower than in the halothane group. In one patient in the enflurane group, the serum inorganic fluoride level increased to 37.5 mumol/l. In this patient renal tubular function may have been affected, but the change was not conclusive since a pronounced rejection of the graft became evident. Since increases in serum inorganic fluoride level approaching 75% of the threshold level for nephrotoxicity in normal kidneys may occur, enflurane should not be routinely used in anesthesia for renal transplantation.
D000768:Anesthesia, General; D003404:Creatinine / Q000097:blood; D004737:Enflurane / Q000378:metabolism; D005459:Fluorides / Q000378:metabolism; D006084:Graft Rejection; D006221:Halothane; D006801:Humans; D007668:Kidney / Q000187:drug effects; D016030:Kidney Transplantation; D009318:Natriuresis; D010197:Pancuronium / Q000008:administration & dosage; D014019:Tissue Donors
D004737:Enflurane; D003404:Creatinine; D010197:Pancuronium; D005459:Fluorides; D006221:Halothane