Glyoxalase phenotypes in patients with diabetes mellitus.
Caucasian diabetic patients in Australian surveys showed a significant difference in the distribution of glyoxalase phenotypes. Insulin dependent diabetic patients with age of onset less than 40 years had a relative excess of glyoxalase homozygote 1-1 and a deficiency of types 2-1 and 2-2. Non-insulin dependent diabetic patients were not significantly different from non-diabetic subjects in the distribution of glyoxalase phenotypes. Insulin dependent diabetic patients without the complications of retinopathy or neuropathy also showed a significant excess of glyoxalase type 1-1 in relation to the control group. Genes controlling glyoxalase polymorphism appear to be associated with the variations of diabetes and its complications.
D001315:Australia; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000235:genetics*; D003929:Diabetic Neuropathies / Q000235:genetics; D003930:Diabetic Retinopathy / Q000235:genetics; D005006:Ethnicity; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007791:Lactoylglutathione Lyase / Q000235:genetics*; D008190:Lyases / Q000235:genetics*; D010641:Phenotype; D013869:Thiolester Hydrolases / Q000235:genetics*; D000099301:Hydroxyacylglutathione Hydrolase
D006680:HLA Antigens; D007328:Insulin; D007791:Lactoylglutathione Lyase; D008190:Lyases; D013869:Thiolester Hydrolases; D000099301:Hydroxyacylglutathione Hydrolase