title: Experimental study on immunological reactions against the articular cartilage.
abstract: In rats immunized with articular cartilage antigens, delayed hypersensitivity was detected by the macrophage migration inhibition test and delayed footpad reaction. Additionally, a proliferative response was found in the regional lymph nodes of immunized rats. The mixed addition of sensitized lymphocytes and antibodies exerted a cytotoxic effect on cultured chondrocytes. Articular damage including accelerated chondrolysis may have some relation to delayed hypersensitivity to autologous articular cartilage antigens.
mesh_terms: D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D001327:Autoimmune Diseases / Q000276:immunology*; D002358:Cartilage, Articular / Q000166:cytology / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D008213:Lymphocyte Activation; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000941:Antigens; D008263:Macrophage Migration-Inhibitory Factors