title: Activity of 4CMB and 4HMB in bacterial mutation assays.
abstract: Conventional pour-plate tests were conducted using 5 Strains of S. typhimurium and 1 E. coli strain. The range of levels examined was 1.6-100 microgram per plate, for both chemicals. 4HMB was inactive in all tests. 4CMB was directly active in all strains, inducing both frameshift and base-substitution mutations in a dose-dependent manner. The largest responses were recorded in strains TA1538 and TA98.
mesh_terms: D001713:Biphenyl Compounds / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D012486:Salmonella typhimurium / Q000187:drug effects; D013045:Species Specificity; D013329:Structure-Activity Relationship
chemical_list: D001713:Biphenyl Compounds; D009153:Mutagens; C033488:4-hydroxymethylbiphenyl; C033487:4-chloromethylbiphenyl