Intestinal immunoglobulin A responses in rabbits to a Salmonella typhi strain harboring a Shigella sonnei plasmid.
Salmonella typhi 5076-IC, which contains a plasmid that encodes the form I antigen of Shigella sonnei and which expresses S. typhi 9 and 12 and S. sonnei form I antigens, was used to immunize rabbits via chronically isolated ileal loops. Intestinal immunoglobulin A activity was detected against S. typhi, S. sonnei form I, and S. typhi strain 5076-IC. Thus S. typhi 5076-IC can effectively elicit mucosal immunoglobulin A to both S. typhi and S. sonnei.
D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics; D007114:Immunization; D007117:Immunization, Secondary; D007070:Immunoglobulin A / Q000096:biosynthesis*; D007413:Intestinal Mucosa / Q000276:immunology*; D010957:Plasmids; D011817:Rabbits; D012485:Salmonella typhi / Q000235:genetics / Q000276:immunology*; D012764:Shigella sonnei / Q000235:genetics / Q000276:immunology*
D000942:Antigens, Bacterial; D007070:Immunoglobulin A