Kinetics of unresponsiveness induced by a short course of cyclosporin A.
The kinetics of unresponsiveness induced by a short course of cyclosporin A was studied using accessory heart allografts in rats. Skin grafts from the heart donor or a third-party donor were performed at several different times after heart transplantation. The fate of the skin and heart grafts demonstrated that the properties of the unresponsive state induced by short-term cyclosporin A therapy changed with time so that three different stages could be recognized: (1) stable nonspecific immunosuppression, (2) weak weak moderately specific immunosuppression, and (3) strong stable donor-specific immunosuppression.
D000818:Animals; D003524:Cyclosporins / Q000627:therapeutic use*; D006085:Graft Survival; D016027:Heart Transplantation; D007165:Immunosuppression Therapy; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains / Q000276:immunology; D016038:Skin Transplantation; D013997:Time Factors
D003524:Cyclosporins