title: Identification of a chemokinetic inhibitor in serum from patients with chronic lymphocytic leukaemia.
abstract: The effects of serum from patients with chronic lymphocytic leukaemia (CCL) on normal polymorphonuclear leucocyte migration (PMN) were examined by means of the leading front technique, using a modified Boyden chamber. 18 randomly selected patients were studied. 13 patients had a reduced chemokinetic activity. The defective migration was explained by the finding in serum from these patients of cell-directed inhibitory activity which was destroyed by heating (56 degrees C, 30 min). The B-lymphocytes as the origin of the inhibitory activity was suggested by the presence of a similar activity in supernatants from cultured tumour cells. 6 of the 18 patients had the combination of a defective chemokinetic activity and low levels of immunoglobulins. These 6 patients had an increased tendency towards infections.
mesh_terms: D000368:Aged; D000626:Aminopeptidases; D001402:B-Lymphocytes / Q000276:immunology; D002464:Cell Migration Inhibition; D002630:Chemotactic Factors / Q000037:antagonists & inhibitors* / Q000276:immunology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007945:Leukemia, Lymphoid / Q000097:blood* / Q000276:immunology; D007961:Leukocyte Migration-Inhibitory Factors / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*
chemical_list: D002630:Chemotactic Factors; D007136:Immunoglobulins; D007961:Leukocyte Migration-Inhibitory Factors; C010073:chemotactic factor inactivator; D000626:Aminopeptidases