title: Large bowel cancer: an overview.
abstract: Cancer of the large bowel is a problem of international scope but with wide national incidence variations possibly related to climatic factors. Neither etiologic studies nor improved methods of early detection have thus far had an impact on national death rates. Surgical treatment, while comparatively effective, does not promise a significant increase in survival data, and thus far, adjuvant therapies have failed to fulfill early enthusiastic expectations. Nevertheless, continued research pursuit of the nature of the neoplastic process, development and application of improved diagnostic and screening methods, and synthesis of better combined modality therapy, will result in substantial improvements in therapeutic results.
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D003110:Colonic Neoplasms / Q000453:epidemiology / Q000601:surgery; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D007414:Intestinal Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery; D007420:Intestine, Large / Q000601:surgery; D008297:Male; D009367:Neoplasm Staging; D011300:Preoperative Care; D012004:Rectal Neoplasms / Q000453:epidemiology / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents; D005472:Fluorouracil