Matching for properdin factor B (Bf) in renal transplantation.
Forty-five donor and recipient primary cadaveric kidney transplant pairs were phenotyped for the properdin factor B (Bf) polymorphism. Graft survival was analyzed on the basis of Bf matching between donor and recipient. Patients receiving a Bf-identical kidney had significantly better graft survival than those receiving a Bf-incompatible kidney (P = 0.045). It is postulated that Bf, which maps in the major histocompatibility system, is a marker for genes of importance in kidney transplant survival.
D011415:Complement Factor B / Q000235:genetics* / Q000276:immunology; D004792:Enzyme Precursors / Q000235:genetics*; D006085:Graft Survival; D006680:HLA Antigens / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation; D010641:Phenotype; D011110:Polymorphism, Genetic
D004792:Enzyme Precursors; D006680:HLA Antigens; D011415:Complement Factor B