[The respiratory complications of D-Penicillamine therapy (author's transl)].
The literature is reviewed on patients developing respiratory symptoms while receiving D-Penicillamine, most of whom suffered from rheumatoid arthritis. The manifestations were (in decreasing frequency) bronchiolitis obliterans, interstitial pneumonitis, a Good pasture's like syndrome and bronchospasm. For each complication we discuss diagnostic criteria, the implication of the drug and the pathogenesis. In addition we make suggestions regarding patients on D-Penicillamine and emphasize the need for accurate reporting of adverse pulmonary effects to enlarge the epidemiological picture.
D019867:Anti-Glomerular Basement Membrane Disease / Q000139:chemically induced; D001249:Asthma / Q000139:chemically induced; D001982:Bronchial Diseases / Q000139:chemically induced; D001986:Bronchial Spasm / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D010396:Penicillamine / Q000009:adverse effects*; D011658:Pulmonary Fibrosis / Q000139:chemically induced
D010396:Penicillamine
Manifestations respiratoires associées aux traitements par la D-Pénicillamine.