title: Renin release after furosemide and ethacrynic acid in man. Evidence for neural reflex control mechanisms.
abstract: The mechanisms of renin release after furosemide (F) and ethacrynic acid (EA) in man were examined. We evaluated whether acute volume shifts within the low pressure system after F induce renin release via neural pathways. Immersion in a water-bath or beta-blockade reduced the increase of plasma renin concentration after F but not after EA. It is concluded that acute renin release after F but not after EA in man is partially due to neurally mediated reflexes originating from volume receptors in the cardiopulmonary area.
mesh_terms: D000328:Adult; D001794:Blood Pressure; D004976:Ethacrynic Acid / Q000494:pharmacology*; D005665:Furosemide / Q000494:pharmacology*; D006339:Heart Rate; D006400:Hematocrit; D006801:Humans; D007101:Immersion; D007668:Kidney / Q000502:physiology; D008297:Male; D012018:Reflex / Q000187:drug effects; D012083:Renin / Q000097:blood / Q000378:metabolism / Q000502:physiology*; D012964:Sodium / Q000652:urine
chemical_list: D005665:Furosemide; D012964:Sodium; D012083:Renin; D004976:Ethacrynic Acid