Differentiation of chronic lymphocytic leukemia from Hodgkin's disease using immunologic marker studies.
Four consecutive lymph node biopsies from one patient showed features typical of lymphocyte-pre-dominant Hodgkin's disease. When the patient developed lymphocytosis of the peripheral blood and a staging bone marrow biopsy was found to have nodular lymphoid infiltrates atypical for Hodgkin's disease, the fourth node biopsy was performed in order to perform immunologic marker studies. A monoclonal cell population was identified and the lymph nodes were interpreted as chronic lymphocytic leukemia mimicking lymphocyte-predominant Hodgkin's disease. The diagnostic usefulness of immunologic marker studies stressed.
D003937:Diagnosis, Differential; D005455:Fluorescent Antibody Technique; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology* / Q000473:pathology; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged