Effects of optical isomers of ketamine on excitation of cat and rat spinal neurones by amino acids and acetylcholine.
The (+) isomer of ketamine was approximately 3 and 1.5 times as potent as the (-) isomer in reducing excitation of rat and cat Renshaw cells by N-methylaspartate (NMA) and acetylcholine (ACh) respectively. The potency ratio of the two isomers of ketamine as NMA antagonists was similar to that obtained in anaesthetic and analgesic tests [16, 19, 25].
D000109:Acetylcholine / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D002415:Cats; D007649:Ketamine / Q000494:pharmacology*; D016202:N-Methylaspartate; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D013116:Spinal Cord / Q000502:physiology*; D013237:Stereoisomerism
D001224:Aspartic Acid; D016202:N-Methylaspartate; D007649:Ketamine; D000109:Acetylcholine