title: The immune system of cyprinid fish. Oxytetracycline and the regulation of humoral immunity in carp (Cyprinus carpio).
abstract: The antibiotic oxytetracycline (oxyTC) was administered either by mixing with food or by intraperitoneal injections. On oxyTC treated animals decreased serum immunoglobulin levels were found. The primary anti-sheep red blood cells (SRBC) response was measured by enumerating plaque forming cells (PFC). It was observed that the PFC response was depressed by 80-95% in oxyTC treated animals. When an anti-SRBC serum was injected together with SRBC the immunosuppressive effect of oxyTC was absent. A secondary anti-SRBC response was not inhibited by oxyTC. On base of the results a model for antigen presentation and the interaction between macrophages, T- and B-like cells during primary and secondary responses in fish is proposed. In primary responses cellular interaction is needed to develop a proper immune response whereas after a high antigen dose challenge SRBC might behave as a T-independent antigen.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001402:B-Lymphocytes / Q000276:immunology; D002347:Carps / Q000276:immunology*; D003530:Cyprinidae / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007156:Immunologic Memory / Q000187:drug effects*; D008264:Macrophages / Q000276:immunology; D008954:Models, Biological; D010118:Oxytetracycline / Q000494:pharmacology*; D012756:Sheep / Q000097:blood; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D010118:Oxytetracycline