title: [Plasmodium falciparum malaria and sickle cell gene in the popular Republic of Congo. I. Relationship between parasitemia and sicke cell trait in Djoumouna (region of Brazzaville) (author's transl)].
abstract: The relationship between sickle cell trait and falciparum malaria was studied in the village of Djoumouna, twenty kilometers south west of Brazzaville. Malaria is characterized by a stable high intensity of transmission on the average one infective mosquito bite by night and by child contrasting with a relatively low malarial infection rate. The prevalence of carriers of an S gene (AS) does not change with age: 22.2% for children under 5 years, 22.1% for childrern between 5 and 15 years, and 22.9% in adults. Malarial infection rates are 32% in homozygous AA children under five years and 38% in AS children, an insignificant difference. Our data for this region of the Congo fail to confirm the hypothesis that the AS genotype protects the carrier against Plasmodium falciparum infection.
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D003223:Congo; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D008288:Malaria / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D010963:Plasmodium falciparum; D012805:Sickle Cell Trait / Q000235:genetics*
vernacular_title: Le paludisme a Plasmodium falciparum et le gène de la drépanocytose en République Populaire du Congo. I. Relation entre la parasitémie et la trait drépanocytaire à Djoumouna (région de Brazzaville).