Separation of prostaglandin E1 from its major metabolites. Application of the technique to measure first-pass clearance of PGE1 in the pulmonary and cerebral circulations of the anesthetized dog.
D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000378:metabolism; D002850:Chromatography, Gel; D002855:Chromatography, Thin Layer; D004285:Dogs; D007201:Indicator Dilution Techniques; D008168:Lung / Q000098:blood supply* / Q000378:metabolism; D008657:Metabolic Clearance Rate; D011458:Prostaglandins E / Q000302:isolation & purification* / Q000378:metabolism; D011817:Rabbits
D011458:Prostaglandins E