Effect of domperidone, an extracerebral inhibitor of dopamine receptors, on thyrotropin, prolactin, renin, aldosterone, and 18-hydroxycorticosterone secretion in man.
This study investigates the dopaminergic mechanisms involved in the control of corticosteroid secretion in normal subjects. TSH, PRL, PRA, aldosterone, and 18-hydroxycorticosterone (18-OHB) were measured before and after the administration of domperidone (10 mg, iv) to eight healthy males. Domperidone, a selective peripheral dopamine antagonist, stimulated TSH and PRL secretion. Plasma concentrations of aldosterone, 18-OHB, cortisol, and PRA were not altered by domperidone. This is in contrast to previous observations of aldosterone, 18-OHB, and PRA responses to metoclopramide, a dopamine antagonist which readily crosses the blood-brain barrier. Domperidone may fail to stimulate aldosterone, 18-OHB, and renin secretion because it does not cross the blood-brain barrier or does not function as an antagonist for adrenal dopamine receptors modulating 18-OHB and aldosterone secretion.
D015069:18-Hydroxycorticosterone / Q000097:blood*; D000328:Adult; D000450:Aldosterone / Q000097:blood*; D001812:Blood-Brain Barrier; D003345:Corticosterone / Q000031:analogs & derivatives*; D004294:Domperidone; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D011388:Prolactin / Q000097:blood*; D011954:Receptors, Dopamine / Q000187:drug effects*; D012083:Renin / Q000097:blood*; D013972:Thyrotropin / Q000097:blood*
D011954:Receptors, Dopamine; D000450:Aldosterone; D004294:Domperidone; D015069:18-Hydroxycorticosterone; D011388:Prolactin; D013972:Thyrotropin; D012083:Renin; D003345:Corticosterone; D006854:Hydrocortisone