Effect of exercise-training on the metabolic manifestations of streptozotocin-induced diabetes in the rat.
Streptozotocin-induced insulin deficiency of a moderate degree was produced in exercise-trained and sedentary young rats, and determinations made of subsequent changes in plasma glucose, triglyceride, and insulin concentrations. Exercise-training attenuated the rise in both plasma glucose and triglyceride concentrations associated with insulin deficiency. Plasma insulin levels were, if anything, lower in exercise-trained rats. Thus, the beneficial effects of exercise-training on plasma glucose and triglyceride concentrations could not be due to the preservation of endogenous insulin secretion, and appear to be secondary to enhanced insulin sensitivity.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D008297:Male; D005082:Physical Exertion; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides