Kainic acid sensitivity of mammalian Purkinje cells in monolayer cultures.
Purkinje cells from fetal mouse cerebellum were studied in a monolayer culture system. These neurons, labeled by intracellular iontophoresis of HRP, showed one or more thick, spine-covered dendrites and an axon whose swellings contacted other neuronal processes and Purkinje cell somata. In short-term experiments, kainic acid was cytotoxic to Purkinje neurons and not to granule cells in monolayer cultures of fetal rat cerebellum.
D000818:Animals; D002478:Cells, Cultured; D002531:Cerebellum / Q000187:drug effects / Q000502:physiology*; D005333:Fetus; D007608:Kainic Acid / Q000494:pharmacology*; D051379:Mice; D008858:Microscopy, Phase-Contrast; D011689:Purkinje Cells / Q000187:drug effects / Q000502:physiology*; D011759:Pyrrolidines / Q000494:pharmacology*
D011759:Pyrrolidines; D007608:Kainic Acid