Effect of single-dose prophylactic co-trimoxazole on the incidence of gynaecological postoperative urinary tract infection.
One hundred patients having abdominal hysterectomy for benign conditions were randomized into two groups; 50 received co-trimoxazole by intramuscular injection immediately before operation and a control group of 50 were given no antibacterial cover. Single-dose chemoprophylaxis with co-trimoxazole was effective in reducing the incidence of postoperative urinary tract infection from 35% in the control group to 4% in the treated group.
D000328:Adult; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007273:Injections, Intramuscular; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D011897:Random Allocation; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000627:therapeutic use*; D014295:Trimethoprim / Q000008:administration & dosage / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000517:prevention & control*
D004338:Drug Combinations; D014295:Trimethoprim; D013420:Sulfamethoxazole