[Nonspecific Shigella suppression of delayed hypersensitivity].
Experimental study in mice has revealed that live virulent shigellae, in contrast to killed ones, suppress the secondary immune response to guinea pig splenocytes, manifested as delayed type hypersensitivity. This suppression is caused by disturbances in the process of the realization of the existing immunological memory: avirulent shigellae have been proved to cause no such effect.
D000818:Animals; D004405:Dysentery, Bacillary / Q000276:immunology; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007156:Immunologic Memory; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012764:Shigella sonnei / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D014774:Virulence
Nespetsificheskaia shigelleznaia supressiia giperchuvstvitel'nosti zamedlennogo tipa.