title: Mitotic aneuploidy induced by sodium deoxycholate in Aspergillus nidulans.
abstract: Sodium deoxycholate is shown to induce aneuploidy in a heterozygous diploid strain of Aspergillus nidulans. It is suggested that this is the result of interference with the normal functioning of the mitotic apparatus through disruption of the nuclear membrane. This effect limits the value of sodium deoxycholate as a paramorphogenic agent in the estimation of the genotoxic effects of environmental and genetic factors.
mesh_terms: D000782:Aneuploidy; D001233:Aspergillus nidulans / Q000187:drug effects / Q000235:genetics*; D003840:Deoxycholic Acid / Q000494:pharmacology; D008040:Genetic Linkage; D005838:Genotype; D008938:Mitosis / Q000187:drug effects*; D009152:Mutagenicity Tests; D009153:Mutagens; D010641:Phenotype
chemical_list: D009153:Mutagens; D003840:Deoxycholic Acid