Cyclosporin A applied topically to the recipient eye inhibits corneal graft rejection.
Corneal graft survival in rabbits was significantly (P less than 0 . 001) prolonged by topical treatment to the recipient eye with cyclosporin A 1% in arachis oil applied five times daily for 4 weeks. No graft was rejected whilst treatment was maintained but all grafts subsequently underwent rejection by the 64th postoperative day. All animals in a simultaneous control group in this fully masked study developed allograft reactions by the 23rd day. No local or systemic side-effects attributable to cyclosporin A were observed. It is believed that this is the first report of inhibition of an allograft reaction by cyclosporin A applied topically.
D000818:Animals; D016039:Corneal Transplantation; D003524:Cyclosporins / Q000494:pharmacology*; D003864:Depression, Chemical; D006084:Graft Rejection / Q000187:drug effects*; D011817:Rabbits; D013997:Time Factors
D003524:Cyclosporins