The mode of action of nosiheptide (multhiomycin) and the mechanism of resistance in the producing organism.
The mode of action of nosiheptide (multhiomycin) on bacterial protein synthesis is closely similar to that of thiostrepton. Both antibiotics inhibit functions of elongation factors Tu and G and greatly reduce the synthesis of guanosine penta- and tetraphosphates in response to stringent factor. Furthermore, the actinomycetes which produce these antibiotics defend themselves against their products in similar fashion. This involves specific pentose-methylation of 23S ribosomal RNA.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000096:biosynthesis; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D008745:Methylation; D010429:Pentoses / Q000494:pharmacology; D010445:Peptide Elongation Factors / Q000378:metabolism; D012270:Ribosomes / Q000187:drug effects*; D013302:Streptomyces / Q000187:drug effects / Q000378:metabolism; D013844:Thiazoles / Q000494:pharmacology; D013883:Thiostrepton / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D010429:Pentoses; D010445:Peptide Elongation Factors; D013844:Thiazoles; C014134:nosiheptide; D013883:Thiostrepton