[Autoradiographic study of cell kinetics after whole-body x-ray irradiation. I. Study of the mode of death of lethally damaged proliferating cells in the subependymal zone of the rat brain].
Autoradiographic study was carried out on the rat brain subependymal cells. 3H-thymidine was injected 60-80 minutes before the whole body X-irradiation in doses of 50, 150 or 300 R. The increase with time of the portion of labeled interphase cells and cells with pycnotic nuclei, and the decrease by two times in the number of grains over picnotic nuclei testified that cells irradiated in G2- and S-phages died afer entering into the first post-irradiation mitosis ("mitotic death"). The lethally damaged cells started their progression through the mitotic cycle to undergo mitosis after one hour block independent of the irradiation dose.
D000818:Animals; D001345:Autoradiography; D002455:Cell Division / Q000528:radiation effects; D002470:Cell Survival / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004805:Ependyma / Q000528:radiation effects*; D007399:Interphase / Q000528:radiation effects; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014916:Whole-Body Irradiation
Avtoradiograficheskoe issledovanie kletochnoĭ kinetiki posle obshchego rentgenovskogo oblucheniia. I. Izuchenie spoba gibeli letal'no povrezhdennykh proliferiruiushchikh kletok subépendimnoĭ zony golovnogo mozga krys.