title: Prospective clinical trial on the efficacy of amoxycillin administered twice or four times daily in children with respiratory tract infections.
abstract: Thirty-four children with upper or lower respiratory tract infections were randomly allocated to receive either a twice daily or four times daily dose of 50 mg amoxycillin/kg body-weight/day. Mean duration of therapy was identical in both groups. Peak and trough antibiotic concentrations were determined. Eradication of bacteria, clinical improvement and side-effects were comparable in both groups.
mesh_terms: D000284:Administration, Oral; D000658:Amoxicillin / Q000008:administration & dosage*; D001424:Bacterial Infections / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D006801:Humans; D007223:Infant; D011446:Prospective Studies; D011897:Random Allocation; D012141:Respiratory Tract Infections / Q000188:drug therapy*
chemical_list: D000658:Amoxicillin