Skin pathology following epicutaneous exposure to seven organic solvents.
1,1,1,-Trichloroethane, benzene, trichloroethylene, tetrachloroethylene, dibromoethane, 1,2-dichloroethane, and 1,1,2,2-tetrachloroethane were applied to the skin of guinea-pigs for histopathological studies. Biopsies taken at different times of exposure showed the presence of karyopyknosis for all solvents tested; 1,1,1-trichloroethane, benzene, trichloroethylene, and tetrachloroethylene showed karyolysis; 1,1,1-trichloroethane, benzene, trichloroethylene, tetrachloroethylene, and dichloroethane induced spongiosis. All solvents, except 1,1,2,2-tetrachloroethane, produced junctional separation. Pseudoeosinophilic infiltration occurred for all solvents, except for 1,2-dichloroethane. The results are discussed in terms of occupational hazards and in relation to parallel studies on blood uptake and systemic toxicity at epicutaneous administration.
D000818:Animals; D001554:Benzene / Q000009:adverse effects; D003877:Dermatitis, Contact / Q000139:chemically induced* / Q000473:pathology; D004980:Ethane / Q000009:adverse effects / Q000031:analogs & derivatives; D015946:Ethylene Dibromide / Q000009:adverse effects; D005025:Ethylene Dichlorides / Q000009:adverse effects; D006168:Guinea Pigs; D006843:Hydrocarbons, Chlorinated / Q000009:adverse effects; D009787:Occupational Medicine; D012871:Skin Diseases / Q000473:pathology*; D013750:Tetrachloroethylene / Q000009:adverse effects; D014240:Trichloroethanes / Q000009:adverse effects; D014241:Trichloroethylene / Q000009:adverse effects
D005025:Ethylene Dichlorides; D006843:Hydrocarbons, Chlorinated; D014240:Trichloroethanes; C015530:1,1,2,2-tetrachloroethane; D015946:Ethylene Dibromide; D014241:Trichloroethylene; D001554:Benzene; D004980:Ethane; D013750:Tetrachloroethylene