Mechanism of 3-phenylpyruvate-induced insulin release from isolated pancreatic islets.
3-Phenylpyruvate evoked a monophasic insulin release from perifused mouse islets. L-Phenylalanine was not an insulin secretagogue and was oxidized by islets at a very low rate, suggesting that 3-phenylpyruvate does not trigger insulin release by enhancing production of reducing equivalents. Moreover, allosteric activation of glutamate dehydrogenase does not play a role in 3-phenylpyruvate-induced insulin secretion.
D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D051379:Mice; D010084:Oxidation-Reduction; D010649:Phenylalanine / Q000494:pharmacology; D010667:Phenylpyruvic Acids / Q000494:pharmacology*; D013268:Stimulation, Chemical
D000596:Amino Acids; D007328:Insulin; D010667:Phenylpyruvic Acids; D010649:Phenylalanine; D005969:Glutamate Dehydrogenase; C031606:phenylpyruvic acid