Tumor-directed immunity in human neuroblastoma.
Tumor-directed immunity was assessed in 29 patients with neuroblastoma (NB). Cell-mediated and humoral immunity were assessed in vitro using the one-stage direct capillary leukocyte migration inhibition test and the indirect, membrane immunofluorescence test, respectively. Leukocytes from 83% of NB patients, 40% of normal children, and 24% of adults were inhibited by NB-derived materials. NB patients' leukocytes reacted as frequently with materials from allogeneic neuroblastomas as with autologous extracts. Sera from 50% of NB patients, 8% of child controls, and 18% of adult controls reacted with allogeneic tissue cultured neuroblastoma cells. Leukocytes from NB patients, control children, and control adults were inhibited at a similar low frequency by extracts of human melanomas and cancers of cervix, colon, and breast. Sera from NB patients and controls reacted infrequently with cultured melanoma cells.
D000917:Antibody Formation; D002464:Cell Migration Inhibition; D002648:Child; D002675:Child, Preschool; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007111:Immunity, Cellular; D007223:Infant; D007962:Leukocytes / Q000276:immunology; D008297:Male; D008545:Melanoma / Q000276:immunology; D009447:Neuroblastoma / Q000276:immunology*