title: Biotransformation of aloenin, a bitter glucoside constituent of Aloe arborescens, by rats.
abstract: Aloenin has been established to be 4-methoxy-6-(2-beta-D-glucopyranosyloxy-4-hydroxy-6-methylphenyl)-2-pyrone; it shows an inhibitory activity for gastric juice secretion. Rats metabolized it to 4-methoxy-6-(2,4-dihydroxy-6-methylphenyl)-2-pyrone, 2,5-dimethyl-7-hydroxychromone and glucose, which were excreted in the feces and the urine. The distribution of the radioactivity originating from 14C-labeled aloenin was studied. The tracer found in the kidney and the liver reached 60% of the amount administered 24 h after feeding and decreased rapidly in the next 24 h.
mesh_terms: D000818:Animals; D001711:Biotransformation; D002250:Carbon Radioisotopes; D005753:Gastric Mucosa / Q000378:metabolism; D005960:Glucosides / Q000378:metabolism*; D006027:Glycosides / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D010944:Plants; D011865:Radioisotope Dilution Technique; D051381:Rats
chemical_list: D002250:Carbon Radioisotopes; D005960:Glucosides; D006027:Glycosides; C033526:aloenin