title: Different efficiency of mercurascan in allograft survival prolongation in male and female mice.
abstract: The efficiency of mercurascan on prolongation of skin allograft survival was found to depend on the sex of experimental animals. Long-term treatment of the recipients by MSC in the mouse strain combination B10--B10.LP (donor X recipient, difference in non-H-2 loci) was more efficient in females than in males. The immunosuppressive effect of MSC was weak. MSC had no effect on the survival time of skin or heart allografts in a strain combination with limited H-2 differences [B10.D2--M(504)]. The effect of MSC on the cell membrane was followed in vitro by measurement of the rate of H-2 antigen redistribution on lymphoid cells of animals treated in vivo by MSC. The rate of redistribution on lymphoid cells from MSC-treated females was decreased; no effect was observed in the case of cells from treated males.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005452:Fluoresceins / Q000494:pharmacology*; D006085:Graft Survival / Q000187:drug effects*; D006183:H-2 Antigens; D016027:Heart Transplantation; D007152:Immunologic Capping / Q000187:drug effects; D008297:Male; D051379:Mice; D009941:Organomercury Compounds / Q000494:pharmacology*; D012737:Sex Factors; D016038:Skin Transplantation; D014184:Transplantation, Homologous
chemical_list: D005452:Fluoresceins; D006183:H-2 Antigens; D009941:Organomercury Compounds; C010604:mercurascan