Mouse genes coding for the major class I transplantation antigens: a mosaic structure might be related to the antigenic polymorphism.
The recent isolation, by recombinant DNA techniques, of cloned probes for mouse and human class I major transplantation antigens has initiated the molecular analysis of the corresponding genes. Mouse genes belong to a relatively large multigene family, whose members share extensive structural homologies. Sequence analyses suggest that some genes could have a mosaic structure. This feature might help us to understand one of the distinctive traits of these antigens: their large antigenic polymorphism.
D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D006183:H-2 Antigens / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D051379:Mice; D008957:Models, Genetic; D009030:Mosaicism; D011110:Polymorphism, Genetic
D006183:H-2 Antigens; D006680:HLA Antigens