Antibacterial kinetics of ampicillin against Escherichia coli under simulated in vivo conditions.
We studied the response of Escherichia coli to ampicillin concentrations which decreased logarithmically at elimination half-life values (t1/2a) ranging from one to four hours. The rate of bacterial killing depended on the initial antibiotic concentration (co), but was not significantly affected by t1/2a. Irrespective of co and t1/2a, the bactericidal effect terminated after about three hours of exposure to the drug.
D000667:Ampicillin / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D007700:Kinetics; D008826:Microbial Sensitivity Tests
D000667:Ampicillin