Effect of cadmium and phenobarbital on cerebral aldehyde reductase.
The effect of cadmium (Cd), phenobarbital and of a combination of both on the aldehyde reductase of rat brain cytosol was investigated in vitro. Cd as well as phenobarbital inhibited the enzyme. A combination of both chemicals resulted in an additive inhibition. From these results it is concluded, that only in heavily contaminated people will an interaction between Cd and phenobarbital on the aldehyde reductase level in the brain occur.
D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002104:Cadmium / Q000494:pharmacology*; D003600:Cytosol / Q000201:enzymology; D007700:Kinetics; D009249:NADP / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats
D002104:Cadmium; D009249:NADP; D000429:Alcohol Oxidoreductases; C019642:alcohol dehydrogenase (NADP+); D010634:Phenobarbital