Adrenaline 1% combined with guanethidine 1% versus adrenaline 1%: a randomised prospective double-blind cross-over study.
The hypotensive effect of a combination of guanethidine 1% with adrenaline 1% was compared with adrenaline 1% alone on the eyes of 20 patients with ocular hypertension in a randomised double-blind cross-over trial. The patients received 8 weeks of treatment with each preparation. A significant increase in the hypotensive effect was found by adding guanethidine 1% to adrenaline 1%. This hypotensive effect was maintained over the 8-week period of the trial.
D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations; D004357:Drug Synergism; D004837:Epinephrine / Q000009:adverse effects / Q000627:therapeutic use*; D005901:Glaucoma / Q000188:drug therapy*; D006145:Guanethidine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D011897:Random Allocation
D004338:Drug Combinations; D004837:Epinephrine; D006145:Guanethidine