Metabolic activation of 1,2-dibromoethane by glutathione transferase and by microsomal mixed function oxidase: further evidence for formation of two reactive metabolites.
In liver cytosolic preparations containing added glutathione, radioactivity from [14C]1,2-dibromoethane becomes bound preferentially to added polycytidylic acid. When microsomes and NADPH are present, however, the radioactivity becomes bound selectively to microsomal proteins.
D000818:Animals; D001711:Biotransformation; D015946:Ethylene Dibromide / Q000378:metabolism*; D005982:Glutathione Transferase / Q000494:pharmacology*; D006842:Hydrocarbons, Brominated / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000494:pharmacology*; D010088:Oxidoreductases / Q000494:pharmacology*; D011066:Poly C / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D006842:Hydrocarbons, Brominated; D015946:Ethylene Dibromide; D011066:Poly C; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D005982:Glutathione Transferase