Electron optic study of the lesions induced by Creutzfeldt--Jakob disease virus in the guinea pig.
An electron microscopic study was performed in brain sections from guinea pigs with experimental Creutzfeldt-Jakob disease. Vacuolation of the neuropil, dilatations of the endoplasmic reticulum and lipid accumulations were observed in the grey matter, while the white matter exhibited intramyelinic vacuoles.
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D001921:Brain / Q000648:ultrastructure*; D007562:Creutzfeldt-Jakob Syndrome / Q000473:pathology*; D003712:Dendrites / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006168:Guinea Pigs; D006801:Humans; D008854:Microscopy, Electron; D009457:Neuroglia / Q000648:ultrastructure; D009940:Organoids / Q000648:ultrastructure; D014617:Vacuoles / Q000648:ultrastructure