Mutagenicity of glycerol chlorohydrines and of their esters with higher fatty acids present in protein hydrolysates.
3-chloro-1,2-propanediol and 1,3-dichloro-2-propanol caused base substitutions in Salmonella typhimurium TA1535 both with and without metabolic activation. Metabolic activation seemed to act mainly by decreasing the toxicity of these compounds. A difference in the growth of the wild-type and repair-deficient strains of Escherichia coli was observed only for 1,3-dichloro-2-propanol with S9 mix. Esters of both chlorohydrines with fatty acids has smaller mutagenic effects than unesterified compounds.
D000818:Animals; D001711:Biotransformation; D002728:Chlorohydrins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D004952:Esters / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D011492:Protein Hydrolysates; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship; D000517:alpha-Chlorohydrin / Q000031:analogs & derivatives / Q000494:pharmacology
D002728:Chlorohydrins; D004952:Esters; D009153:Mutagens; D011492:Protein Hydrolysates; C033489:1,3-dichloro-2-propanol; D000517:alpha-Chlorohydrin