Mutants of Escherichia coli that are resistant to certain beta-lactam compounds lack the ompF porin.
Carbenicillin-resistant mutants of Escherichia coli K-12 and B/r were found to produce greatly diminished levels of the porin coded by the ompF gene. Physiological and ecological implications of these findings are discussed.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001425:Bacterial Outer Membrane Proteins; D002228:Carbenicillin / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D005798:Genes, Bacterial; D008565:Membrane Proteins / Q000096:biosynthesis*; D009154:Mutation; D010403:Penicillin Resistance
D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D008565:Membrane Proteins; D002228:Carbenicillin