Digoxin use in the elderly.
The current extensive use of digoxin in elderly patients with left ventricular failure and sinus rhythm may not be clinically justifiable; in a significant proportion of these patients the frequency of digitalis toxicity may outweight the therapeutic benefits of the drug. When digoxin is used in elderly patients, the specific geriatric pharmacology of the drug must be considered. Clinical benefit should be documented before proceeding to long-term maintenance therapy. In selected elderly patients, withdrawal of digoxin with careful follow-up may be a worthwhile procedure. Studies are needed comparing the relative benefits and toxicities of digoxin versus diuretics in the management of heart failure in the elderly.
D000328:Adult; D000367:Age Factors; D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood / Q000188:drug therapy; D004077:Digoxin / Q000009:adverse effects / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use*; D004232:Diuretics / Q000627:therapeutic use; D004347:Drug Interactions; D006207:Half-Life; D006329:Heart Conduction System / Q000503:physiopathology; D006333:Heart Failure / Q000188:drug therapy; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010349:Patient Compliance; D011802:Quinidine / Q000097:blood / Q000627:therapeutic use
D004232:Diuretics; D004077:Digoxin; D011802:Quinidine