[Synergistic effect of thiamphenicol and cephalothin on Bacterioides fragilis (author's transl)].
Synergistic effect of thiamphenicol (TP) and cephalothin (CET) on Bacteroides fragilis was proved in vitro. Especially its effect was much clear on B. fragilis which is possible to produce beta-lactamase. Synergistic bactericidal effect of TP and CET was proved. Chemotherapeutic effect of TP and CET against experimental mixed infectious mouse due to E. coli (beta-lactamase -) and B. fragilis (beta-lactamase +) was proved.
D000818:Animals; D001442:Bacteroides Infections / Q000188:drug therapy; D001441:Bacteroides fragilis / Q000187:drug effects*; D002512:Cephalothin / Q000008:administration & dosage / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004927:Escherichia coli Infections / Q000188:drug therapy; D006801:Humans; D051379:Mice; D013839:Thiamphenicol / Q000008:administration & dosage / Q000494:pharmacology*
D013839:Thiamphenicol; D002512:Cephalothin