[Fenquizone in the medium term treatment of essential hypertension. Double-blind comparison with chlorthalidone and placebo].
In a double blind study, tolerability and antihypertensive effect of fenquizone were compared with those of chlorthalidone and placebo. In both mild and moderately severe essential hypertension, fenquizone and chlortalidone showed a significant antihypertensive effect; moreover, fenquizone lowered the clinostatic arterial diastolic pressure in a more gradual and continuous way. Differently from chlortalidone, fenquizone had no effects on blood levels of potassium and cholesterol.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002752:Chlorthalidone / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004231:Diuresis / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011188:Potassium / Q000652:urine; D011799:Quinazolines / Q000627:therapeutic use*
D010919:Placebos; D011799:Quinazolines; C007712:fenquizone; D002752:Chlorthalidone; D011188:Potassium
I fenquizone nel trattamento a medio termine dell'ipertensione arteriosa essenziale. Confronto in doppio cieco con clortalidone e placebo.