title: Intellectual function in Duchenne muscular dystrophy: the influence of penicillamine.
abstract: No effect of penicillamine upon intelligence was found in boys with Duchenne muscular dystrophy when compared to placebo administered in a double-blind fashion. All children, however, showed a significant progressive decline in intelligence quotient. An analysis of mental age showed no change over a 24-month period, suggesting that a static intellectual deficit exists. These data support other findings of a central nervous system dysfunction in patients with Duchenne muscular dystrophy.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D007360:Intelligence / Q000187:drug effects*; D008297:Male; D009136:Muscular Dystrophies / Q000188:drug therapy / Q000503:physiopathology*; D010396:Penicillamine / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D010396:Penicillamine