The in vivo and in vitro action of 4-amino-5-imidazolecarboxamide in trypanosomatid flagellates.
4-Amino-5-imidazolecarboxamide, but not its riboside or ribotide, is inhibitory to the growth of promastigotes of Leishmania donovani, L. braziliensis, L. tarentolae, and L. mexicana, eventually causing cell lysis. Conversely, it is not inhibitory to the growth of epimastigotes of Trypanosoma cruzi. This substituted imidazole proved to be an excellent inhibitor of guanine deaminase from all of the trypanosomatids used in this study, with Ki values in the microM range.
D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D006148:Guanine Deaminase / Q000037:antagonists & inhibitors; D007093:Imidazoles / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D012263:Ribonucleosides / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development
D007093:Imidazoles; D012263:Ribonucleosides; D000620:Aminoimidazole Carboxamide; C011651:acadesine; D006148:Guanine Deaminase