title: Renin responsiveness to furosemide in the homotransplanted kidney.
abstract: Plasma renin activity (PRA) was measured after repetitive furosemide stimulations in 16 normotensive homotransplanted patients who previously had bilateral nephrectomies. The percentage PRA response to furosemide was very low (34%) in the immediate period after transplantation, but increased progressively with time to a level after one year (111%) which was not statistically different from age and sex matched control subjects. A significant correlation was found between the percentage PRA increase and the number of weeks after transplantation (r = 0.48, P less than 0.01). These data indicate that the juxtaglomerular cell responsiveness to furosemide is quantitatively time dependent after transplantation, and it is a factor that should be considered in the evaluation of renin-angiotensin system in such patients.
mesh_terms: D000328:Adult; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D007668:Kidney / Q000201:enzymology; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012083:Renin / Q000097:blood*; D013268:Stimulation, Chemical; D013997:Time Factors
chemical_list: D005665:Furosemide; D012083:Renin