title: Role of the RES in the pathogenesis of endotoxic hypoglycemia.
abstract: The role of the RES in the alteration of glucose homeostasis was evaluated in male rats treated with S enteritidis endotoxin. Depression of hepatic gluconeogenesis coupled to enhanced peripheral glucose use was substantiated in vivo using the primed-constant infusion technique with 2-3H-D glucose. Immuno-reactive insulin was elevated in the early hyperglycemic phase but declined in endotoxic hypoglycemia. NSILA was elevated in late endotoxin shock. Two monokines--macrophage insulin-like activity (MILA) and macrophage insulin releasing activity (MIRA)--are related to the pathogenesis of endotoxic hypoglycemia.
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D005947:Glucose / Q000378:metabolism; D007003:Hypoglycemia / Q000209:etiology*; D007328:Insulin / Q000378:metabolism / Q000502:physiology; D008264:Macrophages / Q000502:physiology; D008297:Male; D012157:Mononuclear Phagocyte System / Q000502:physiology*; D010179:Pancreas / Q000378:metabolism; D051381:Rats; D012772:Shock, Septic / Q000209:etiology*
chemical_list: D007328:Insulin; D005947:Glucose