title: Treatment of chancroid. Comparison of sulfamethoxazole-trimethoprim with recommended therapies.
abstract: Thirty-five men with chancroid were randomly treated with oral sulfisoxazole, sulfisoxazole and tetracycline, sulfamethoxazole-trimethoprim, or intramuscular streptomycin. The highest rate of cures were obtained in 13 of 13 patients treated with streptomycin and in ten of ten patients treated with sulfamethoxazole-trimethoprim. Only seven of nine patients treated with sulfisoxazole and five of eight treated with sulfisoxazole and tetracycline were cured. We conclude that the sulfamethoxazole-trimethoprim combination is as efficacious as streptomycin and probably superior to sulfisoxazole and tetracycline in the treatment of chancroid.
mesh_terms: D002602:Chancroid / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D011897:Random Allocation; D013307:Streptomycin / Q000008:administration & dosage; D013420:Sulfamethoxazole / Q000008:administration & dosage*; D013444:Sulfisoxazole / Q000008:administration & dosage; D013752:Tetracycline / Q000008:administration & dosage; D014295:Trimethoprim / Q000008:administration & dosage*
chemical_list: D013444:Sulfisoxazole; D014295:Trimethoprim; D013752:Tetracycline; D013420:Sulfamethoxazole; D013307:Streptomycin