title: [Treatment of condyloma acuminatum with 0.5% 5-fluorouracil-solution, A double-blind clinical trial].
abstract: 30 males and 29 females with condyloma acuminatum took part in a double-blind randomized trial with 0,5% 5-fluorouracil (5-FU) salicylic acid containing varnish for warts versus the varnish without 5-FU. The females were treated twice weekly at the clinic, the males were treated once daily at home by themselves. The 5-FU solution was found significantly superior to placebo (P less than 0,01). 60% of the 5-FU treated patients were healed with a median healing time of two weeks in the males and three weeks in the females. In the placebo group 27,6% healed with a median healing time of 2,5 weeks (males) an 3,5 weeks (females). Blood tests obtained before and after the trial were normal. Patch tests with 0,5% 5-FU revealed no sensitization after the therapy.
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D001005:Anus Neoplasms / Q000188:drug therapy; D002986:Clinical Trials as Topic; D003218:Condylomata Acuminata / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010412:Penile Neoplasms / Q000188:drug therapy; D010502:Perineum; D014523:Urethral Neoplasms / Q000188:drug therapy; D014565:Urogenital Neoplasms / Q000188:drug therapy*; D014625:Vaginal Neoplasms / Q000188:drug therapy; D014846:Vulvar Neoplasms / Q000188:drug therapy
chemical_list: D005472:Fluorouracil
vernacular_title: Behandlung von Condyloma acuminatum mit 0,5% 5-Fluorouracil-Lösung.