Glycosaminoglycan synthesis by human diabetic, normal adult, and embryonic fibroblasts in relation to insulin levels.
Sulfated glycosaminoglycan synthesis by human diabetic, non-diabetic, and embryonic cells was studied. No effect of insulin on net synthesis was noted. Thus, the data do not indicate a role for total sulfated glycosaminoglycan production in the diabetic connective tissue disturbance mediated by insulin.
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000096:biosynthesis*; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D006025:Glycosaminoglycans; D007328:Insulin