[Studies into dependence of sensitivity of cytostatics on overlap index of ovarian cancer in cell cultures (author's transl)].
Overlap index and cytostatic sensitivity pattern were determined from 66 cell cultures of ovarian carcinoma. The average overlap index of all cell cultures tested was 42.2 per cent +/- 20.5 and proved to be equivalent to that of malignant tumours in different locations. The wide scatter was attributed to the biological individuality of ovarian carcinoma. High overlap indices usually are indicators to high sensitivity to cytostatics, whereas low overlap indices may reflect low sensitivity or even resistance to cytostatic agents. Yet, no high-accuracy prediction can be made for the real individual case. The question is raised, if both parameters are separate and independent indicators to characterise a given tumour or parameters with correlations between them.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002467:Cell Nucleus; D002478:Cells, Cultured; D003584:Cytological Techniques; D004351:Drug Resistance; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000032:analysis / Q000188:drug therapy*; D010347:Patient Care Planning
D000970:Antineoplastic Agents
Untersuchungen zur Abhängigkeit de Zytostatikasensibilität vom Kernüberlappungsindex in vitro kultivierter Ovarialkarzinome.