Surface receptors on lymphoreticular cells: sensory devices for host recognition of foreign antigens and neoplasia.
Distinct types of cells in the lymphoreticular system regulate an individual's immunologic homeostasis and response to disease. By means of multiple receptors the cell membrane transfers signals between the environment and the cell. This article reviews the important surface antigens and receptors on normal and activated macrophages (e.g., receptors for the crystallizable fragment [Fc] of immunoglobulin), on lymphocytes derived from the bone marrow (e.g., immunoglobulins and immune-associated [Ia] antigens), on thymus-derived lymphocytes (e.g., Thy-1 antigens) and on "null' cells. Although many of these markers were originally defined in rodents and birds, analogous markers in humans have proved extremely useful in characterizing lymphoreticular cell populations in healthy and sick individuals. Established and postulated functions of the markers in host defence mechanisms are discussed.
D000951:Antigens, Neoplasm / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology / Q000502:physiology; D006801:Humans; D007519:Isoantigens / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008285:Major Histocompatibility Complex; D012157:Mononuclear Phagocyte System / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D007519:Isoantigens