Characterization of the active site of ribonucleotide reductase of Escherichia coli, bacteriophage T4 and mammalian cells by inhibition studies with hydroxyurea analogues.
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D004926:Escherichia coli / Q000201:enzymology*; D005347:Fibroblasts / Q000201:enzymology; D006144:Guanazole / Q000494:pharmacology; D006918:Hydroxyurea / Q000031:analogs & derivatives* / Q000494:pharmacology; D066298:In Vitro Techniques; D051379:Mice; D009603:Nitroso Compounds / Q000494:pharmacology; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013604:T-Phages / Q000201:enzymology*; D013950:Thymus Gland / Q000201:enzymology*
D009603:Nitroso Compounds; C001259:Fremy's salt; D012264:Ribonucleotide Reductases; D006144:Guanazole; D006918:Hydroxyurea