A gonadotrophin-releasing hormone agonist stimulates oxygen consumption and maturation of follicle-enclosed rat oocytes in vitro.
Rat oocytes were induced to resume meiosis by incubating isolated preovulatory follicles with LH or a gonadotrophin-releasing hormone (GnRH) agonist. Oocyte maturation was accompanied by a 32% increase in oxygen consumption by the denuded oocyte after incubation with LH and a 67% increase after incubation with the GnRH agonist.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D007986:Luteinizing Hormone / Q000494:pharmacology*; D008540:Meiosis / Q000187:drug effects; D009865:Oocytes / Q000187:drug effects* / Q000378:metabolism; D010063:Ovum / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects*; D010906:Pituitary Hormone-Releasing Hormones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D010906:Pituitary Hormone-Releasing Hormones; D007986:Luteinizing Hormone