[Mechanism of action of nonachlazine and ethmozine on the cardiac blood supply in acute myocardial ischemia].
In anesthetized cats, intravenous administration of nonachlazin (1 and 6 mg/kg) and ethmozine (2 and 5 mg/kg) led, 5 minutes after ligation of the anterior descending branch of the left coronary artery, to the increased blood outflow from the coronary sinus and to a less marked elevation of myocardial oxygen consumption. The coronarodilatory effect of the drugs fell in the presence of a preliminary injection of the sympatholytic octadin (25 mg/kg intraperitoneally), atropine (0.5 mg/kg intravenously), alpha-adrenoblocker dihydroergotoxin (2 mg/kg intravenously), and beta-adrenoblocker obsidan (0.5 mg/kg intravenously). Nonachlazin and ethmozine decreased the pituitrin-induced (2 ED/kg intravenously) spasm of the coronary vessels of the affected heart.
D000208:Acute Disease; D000818:Animals; D002415:Cats; D003326:Coronary Circulation; D003327:Coronary Disease / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D008297:Male; D016293:Moricizine; D009025:Morpholines / Q000627:therapeutic use; D009206:Myocardium / Q000378:metabolism; D009628:Nonachlazine / Q000627:therapeutic use*; D010101:Oxygen Consumption; D010640:Phenothiazines / Q000627:therapeutic use*
D009025:Morpholines; D010640:Phenothiazines; D016293:Moricizine; D009628:Nonachlazine
K mekhanizmu deĭstviia nonakhlazina i étmozina na krovosnabzhenie serdtsa pri ostroĭ ishemii miokarda.