Respiratory syncytial virus infection in cyclophosphamide-treated cotton rats.
Cotton rats infected intranasally with respiratory syncytial virus and immunosuppressed with cyclophosphamide shed virus for at least 7 weeks. Dissemination of virus beyond the respiratory tract was observed. In contrast, virus was recovered from infected, non-immunosuppressed rats for only 1 week, and only from the respiratory tract.
D000818:Animals; D003411:Arvicolinae; D001980:Bronchi / Q000382:microbiology; D003520:Cyclophosphamide / Q000494:pharmacology; D007108:Immune Tolerance; D007668:Kidney / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D009297:Nasal Mucosa / Q000382:microbiology; D012136:Respiratory Syncytial Viruses / Q000302:isolation & purification; D010253:Respirovirus Infections / Q000276:immunology* / Q000382:microbiology
D003520:Cyclophosphamide