Review of glucocorticoid pharmacology.
Rational glucocorticoid therapy depends on a complicated interplay of many factors. An understanding of the physiology of the hypothalamic-pituitary-adrenal axis, the comparative potencies, duration, and adverse effects of the available corticosteroid bases and their esters, and especially the specific goals of the therapy for a wide variety of diseases facilitates this therapy. It is impossible to make specific dose recommendations for glucocorticoid therapy. Individual patients and their various diseases respond differently to a given dose of glucocorticoid.
D000820:Animal Diseases / Q000188:drug therapy; D000818:Animals; D003345:Corticosterone / Q000378:metabolism; D004285:Dogs; D005938:Glucocorticoids / Q000494:pharmacology* / Q000502:physiology / Q000627:therapeutic use; D005947:Glucose / Q000378:metabolism; D006854:Hydrocortisone / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D007329:Insulin Antagonists; D050356:Lipid Metabolism; D010913:Pituitary-Adrenal System / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D013329:Structure-Activity Relationship
D005938:Glucocorticoids; D007329:Insulin Antagonists; D011506:Proteins; D005947:Glucose; D003345:Corticosterone; D006854:Hydrocortisone