The immune response of CBA mice to OSRA, a peripheral protein from the sheep erythrocyte membrane.
The capacity of a membrane protein from sheep erythrocytes (osmotic shock released antigen: OSRA) to elicit an immune response in CBA mice was investigated. While all OSRA preparations tested are antigenically identical en indistinguishable with respect to physicochemical characteristics, they are not equally efficient in stimulating immunocompetent lymphocytes for antibody production upon a primary immunization (immunogenic versus antigenic OSRA). Both antibody-forming and (T and B) memory cells are generated in mice primed with immunogenic OSRA. Evidence is presented that the failure of antigenic OSRA to induce a primary response to SRBC determinants is related to its inability to stimulate unprimed T-cells. OSRA appears to be a major antigenic determinant of the sheep erythrocyte membrane since it specifically inhibits up to 60% of an anti-SRBC response.
D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000276:immunology; D000954:Antigens, Surface; D001798:Blood Proteins; D004910:Erythrocyte Membrane / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006462:Hemolytic Plaque Technique; D006736:Horses; D007156:Immunologic Memory; D008297:Male; D008565:Membrane Proteins / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D009997:Osmotic Pressure; D011817:Rabbits; D012756:Sheep
D000954:Antigens, Surface; D001798:Blood Proteins; D008565:Membrane Proteins; C031423:osmotic shock released antigen