Influence of prophylactic treatment with gamma-immunoglobulins on renal function after kidney transplantation in rhesus monkeys.
The effect of prophylactic i.v. administration of high doses of human gamma-immunoglobulin (IgG) on kidney graft survival was investigated in rhesus monkeys treated with azathioprine and prednisolone. In nontransfused recipients not treated with IgG (controls), graft survival ranged from 9 to 22 days; if nontreated animals had been given three pretransplant blood transfusions, graft survival ranged from 9 to 61 days with 42% of the animals showing a prolonged survival time (greater than 22 days). However, in both transfused and nontransfused recipients, the additional pretransplant administration of IgG appeared to have an adverse effect: about 25% of the animals showed accelerated rejection. In addition, serum creatinine levels in IgG-treated recipients were significantly higher on the 3rd day after transplantation than in non-treated monkeys. We concluded that renal transplant patients should be treated with IgG for protection against life-threatening infections only if they have good kidney function.
D000818:Animals; D001379:Azathioprine / Q000627:therapeutic use; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D006650:Histocompatibility Testing; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D016030:Kidney Transplantation; D008253:Macaca mulatta / Q000276:immunology; D011239:Prednisolone / Q000627:therapeutic use
D007074:Immunoglobulin G; D011239:Prednisolone; D001379:Azathioprine