Blood flow, histamine content and histidine decarboxylase activity in rat skin grafts and their modification by cyclosporin-A.
1 An attempt has been made to monitor simultaneously the changes in blood flow, histamine content, histidine decarboxylase (HDC) activity and mast cell population in rat skin isografts and allografts. 2 The histamine content in rat skin allografts during rejection was decreased in contrast with our earlier observation in rabbits. 3 Although no definite correlation has been found between blood flow changes, histamine content or HDC activity, a reciprocal relationship appeared to exist between histamine content and HDC activity in the skin grafts, which might be a reflection of the immunosuppressive activity of this amine. 4 The immunosuppressive agent, cyclosporin-A (20 mg/kg daily) was able to prolong skin allograft survival and prevent the changes in histamine and HDC activity in allografts. 5 Possible implications of these findings are discussed in relation to current knowledge concerning the interactions between endothelial cells, lymphocytes and mast cells/basophils in graft rejection.
D000818:Animals; D002262:Carboxy-Lyases / Q000032:analysis*; D003524:Cyclosporins / Q000494:pharmacology*; D006632:Histamine / Q000032:analysis*; D006640:Histidine Decarboxylase / Q000032:analysis*; D008407:Mast Cells; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000032:analysis / Q000098:blood supply; D016038:Skin Transplantation
D003524:Cyclosporins; D006632:Histamine; D002262:Carboxy-Lyases; D006640:Histidine Decarboxylase