The effects of BC, 4CMB and 4HMB upon the induction of mitotic gene conversion in yeast.
Both BC and 4CMB but not 4HMB were shown to be capable of inducing mitotic gene conversion in exponential phase cultures of the JDI strain of the yeast Saccharomyces cerevisiae. The results obtained indicate that in terms of the relative frequency of genetic events per lethal event 4CMB was more active than BC in this test system.
D000818:Animals; D001593:Benzyl Compounds / Q000494:pharmacology*; D001711:Biotransformation; D001713:Biphenyl Compounds / Q000494:pharmacology*; D005785:Gene Conversion; D005804:Genes, Lethal / Q000187:drug effects; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013329:Structure-Activity Relationship
D001593:Benzyl Compounds; D001713:Biphenyl Compounds; D009153:Mutagens; C033488:4-hydroxymethylbiphenyl; C033487:4-chloromethylbiphenyl; C021292:benzyl chloride