title: [Clinically relevant aspects of ethanol metabolism].
abstract: A general survey of the ethanol metabolism and the sequels resulting from this of different kind and intensiveness is given. The speed of the absorption of ethanol is determined according to the laws of diffusion above all by dose and concentration of the ethanol taken. The duration corresponding to the facts varies in broad limits between 10 and 180 min. Nearly simultaneously with the absorption the distribution of the ethanol into the tissues takes place. According to its overwhelming water solubility the ethanol content of the individual tissues is of different size when a distribution balance developed. Three enzyme systems independent of each other, the ADH, the MEOS and the katalase participate in the elimination of the ethanol, the maximum speed of degradation of which lies at the in every case different values of blood alcohol. These three enzyme systems further differ by various localisation, inhibitors, coferments, beginning of activity, optimum of activity and adaptive induction to ethanol. Demarcating for the first step of degradation and thus finally of the ethanol degradation in general might probably be the reoxydation rate, particularly of the NADH, and its repeated inclusion into the ethanol metabolism. Chronic intake of alcohol has multiple effects, among others due to the perhaps temporarily limited adaptive induction of MEOS it has altogether higher rates of degradation. These again have numerous negative sequels with sensitive disturbance of numerous physiologic processes of the intermediary metabolism, in which cases through functional processes finally result organic changes of different kind.
mesh_terms: D000042:Absorption; D000429:Alcohol Oxidoreductases / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D003067:Coenzymes / Q000378:metabolism; D000431:Ethanol / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption; D008099:Liver / Q000201:enzymology; D008862:Microsomes, Liver / Q000201:enzymology; D009061:Mouth Mucosa / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D003067:Coenzymes; D011773:Pyruvates; D009243:NAD; D000431:Ethanol; D000429:Alcohol Oxidoreductases; D002374:Catalase
vernacular_title: Einige klinisch relevante Aspekte des Ethanolstoffwechsels.