Use of propranolol to control rate-pressure product during cardiac anesthesia.
The use of propranolol to control heart rate (HR), systolic pressure, and rate-pressure product (RPP) during laryngoscopy and sternotomy was studied in 21 patients, New York Heart Association functional Classes 1 and 2, scheduled for coronary artery bypass graft surgery. All patients were anesthetized in an identical fashion, but the treatment group (N = 13) received propranolol, 0.5 to 1 mg IV, 4 minutes before laryngoscopy and again, in most cases, before skin incision. Patients not given propranolol (N = 8) showed a clinically and statistically significant increase in HR and RPP, whereas HR and RPP remained essentially unchanged from the preanesthetic period in patients given propranolol.
D000758:Anesthesia; D001794:Blood Pressure / Q000187:drug effects*; D002986:Clinical Trials as Topic; D001026:Coronary Artery Bypass; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use*; D011897:Random Allocation
D011433:Propranolol