title: Two-dose comparison of chlormezanone in sleep disturbance due to anxiety.
abstract: A double-blind, crossover, multi-centre study was carried out in general practice on 76 patients with mild neurotic anxiety and associated sleep disturbance to compare the effectiveness of chlormezanone given as a single night-time dose of 200 mg or 400 mg, each given for a period of 1 week. There was a significant improvement in the quality and duration of sleep with both dosages, and this was significantly greater with the higher dose. Both doses produced a similarly significant improvement in the frequency of awakening refreshed, and reduction in anxiety rating. The higher dose was considered overall more effective, and significantly more patients preferred it.
mesh_terms: D001008:Anxiety Disorders / Q000188:drug therapy* / Q000523:psychology; D002720:Chlormezanone / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011581:Psychological Tests; D011897:Random Allocation; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy* / Q000523:psychology; D012894:Sleep Stages / Q000187:drug effects
chemical_list: D002720:Chlormezanone