title: Evaluation of the genetic activity of industrially produced carbon black.
abstract: Commercially produced oil furnace carbon black (Chemical Abstract Service Registry No. 1333-86-4) has been evaluated by five different assay for genetic activity. These were the Ames Salmonella typhimurium reverse mutation test, sister chromatid exchange test in CHO cells, mouse lymphoma test, cell transformation assay in C3H/10T1/2 cells, and assay for genetic effects in Drosophila melanogaster. Limited cellular toxicity was exhibited but no significant genetic activity was noted.
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000395:Air Pollutants, Occupational / Q000633:toxicity*; D000818:Animals; D002244:Carbon / Q000633:toxicity*; D002478:Cells, Cultured; D002999:Clone Cells / Q000187:drug effects; D006224:Cricetinae; D005260:Female; D008223:Lymphoma / Q000503:physiopathology; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens; D009374:Neoplasms, Experimental / Q000503:physiopathology; D012486:Salmonella typhimurium / Q000235:genetics; D012854:Sister Chromatid Exchange / Q000187:drug effects; D014998:Y Chromosome / Q000187:drug effects
chemical_list: D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D009153:Mutagens; D002244:Carbon