[Cells of hematopoietic origin in the connective tissue of various organs in xenogeneic murine radiation chimeras].
The distribution of donor cells in the connective tissue of different organs of xenogeneic (rat in mouse) radiation chimaeras was studied under the normal conditions and upon its de novo formation. The donor cells were identified by means of indirect immunofluorescent method with the use of specific antiserum against surface antigens of the rat bone marrow cells. It was shown that macrophages of subcutaneous connective tissue, lung alveolar macrophages, Kuppfer's cells, macrophages of intestinal mucosa in the long living radiochimaeras were represented by the donor cells. The fibroblast-like cells of donor origin were found in the subcutaneous loose connective tissue, among the connective tissue elements of cross striated muscles, in the cardiac muscle, in the intestinal mucosa. The repopulation of Peyer's patches of the radiochimaeras by the donor cells was demonstrated. The macrophages of hemopoietic origin (donor origin) were found in the inflammatory granuloma in the brain cortex. The donor cells were found in the connective tissue of mammary glands following the hormonal stimulation. Differences were found with respect to binding of the antiserum used to cells of the capsule around the foreign body in different organs of xenogeneic chimaeras.
D000818:Animals; D016026:Bone Marrow Transplantation; D003239:Connective Tissue Cells; D005260:Female; D005455:Fluorescent Antibody Technique; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011828:Radiation Chimera; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014183:Transplantation, Heterologous
Kletki krovetvornogo proiskhozhdeniia v soedinitel'noĭ tkani raznykh organov ksenogennykh myshinykh radiatsionnykh khimer.