title: Synthetic inhibitors of alcohol dehydrogenase. Pyrazoles containing an unsaturated hydrocarbon residue in the 4-position.
abstract: A series of pyrazoles containing an unsaturated hydrocarbon residue in the 4-position has been synthesized and tested for ability to inhibit the activity of the enzyme liver alcohol dehydrogenase. These compounds were found to be less active than the corresponding saturated analogues.
mesh_terms: D000426:Alcohol Dehydrogenase; D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006736:Horses; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D011720:Pyrazoles; D000429:Alcohol Oxidoreductases; D000426:Alcohol Dehydrogenase