[Specific I125-insulin binding in the plasma membrane of adipose tissue cells in pheochromocytoma].
Specific 125I-insulin binding with the fat cellular plasma membranes was studied in 7 patients with pheochromocytoma. It was shown that the concentration of insulin receptors in plasma membranes and their affinity to insulin decreased and the negative cooperative interaction between receptors rose in patients with pheochromocytoma comparatively to normal subjects.
D000273:Adipose Tissue / Q000473:pathology*; D000310:Adrenal Gland Neoplasms / Q000473:pathology*; D000328:Adult; D002462:Cell Membrane / Q000378:metabolism; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000473:pathology*; D011972:Receptor, Insulin / Q000378:metabolism*
D007328:Insulin; D007457:Iodine Radioisotopes; D011972:Receptor, Insulin
Spetsificheskoe sviazyvanie 125I-insulina v plazmaticheskikh membranakh zhirovykh kletok u bol'nykh feokhromotsitomoĭ.