title: Effects of cimetidine on the elimination and actions of ethanol.
abstract: The influence of cimetidine hydrochloride (300 mg four times daily for seven days) on plasma ethanol concentrations and the subjective assessment of intoxication after a single oral dose of ethanol (0.8 g/kg) were investigated in a randomized double-blind placebo controlled study in six volunteers. Compared with the placebo, cimetidine produced a small increase in both the peak plasma ethanol level (from 146 +/- 5.2 to 163 +/- 7.6 mg/dL, mean +/- SEM) and th area under the ethanol concentration time curve (from 717 +/- 17 to 771 +/- 44 mg/dLXhr). In addition, using a visual analogue scale, subjects rated themselves more intoxicated at their peak of intoxication while receiving cimetidine. These results suggest that cimetidine has a small effect on the handling of ethanol in humans.
mesh_terms: D000328:Adult; D000435:Alcoholic Intoxication / Q000097:blood; D002927:Cimetidine / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004357:Drug Synergism; D000431:Ethanol / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011897:Random Allocation
chemical_list: D006146:Guanidines; D000431:Ethanol; D002927:Cimetidine