title: Induction of transplantation tolerance in guinea pigs by spleen allografts. I. Operative techniques and clinical results.
abstract: Four hundred and ten heterotopic spleen transplants were performed in inbred guinea pigs of strains 2 and 13 whose major histocompatibility complex differs only in the I region and which rapidly reject reciprocal skin allografts. Spleen allografts from strain 13 to strain 2 survived throughout the lifetime of the hosts, whereas spleen allografts from strain 2 to strain 13 were rejected within 3 weeks. Animals not rejecting their spleen transplants were specifically tolerant of donor strain skin allografts. Strain 2 recipients of strain 13 spleen grafts had a surprising high mortality from graft-versus-host disease which peaked at 6 weeks after transplantation.
mesh_terms: D000818:Animals; D005260:Female; D006085:Graft Survival; D006168:Guinea Pigs / Q000601:surgery*; D007108:Immune Tolerance; D007158:Immunologic Techniques; D008285:Major Histocompatibility Complex; D008297:Male; D016038:Skin Transplantation; D013154:Spleen / Q000637:transplantation*; D013514:Surgical Procedures, Operative