Tiaprofenic acid (surgam) in the treatment of osteoarthritis of the knee and hip.
Tiaprofenic acid 200 mg three times a day was compared with indomethacin 25 mg three times a day in 36 patients suffering from osteoarthritis of the knee and hip. In this double-blind cross-over study little significant difference in efficacy between the drugs was seen. Although no significant difference in adverse effects was found, significantly fewer central nervous system side-effects were associated with tiaprofenic acid treatment.
D000368:Aged; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006621:Hip Joint; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007719:Knee Joint; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D011422:Propionates / Q000009:adverse effects / Q000627:therapeutic use*; D011897:Random Allocation; D013876:Thiophenes / Q000009:adverse effects / Q000627:therapeutic use*
D011422:Propionates; D013876:Thiophenes; C021270:tiaprofenic acid; D007213:Indomethacin