Immune Unresponsiveness to platelets. A case study.
Both 51Cr-survival studies with donor platelets and allogenic skin transplantations were performed in a patient with immune unresponsiveness to platelet antigens, i.e., HLA-and platelet-specific antigens. The patients, who suffered from hypoplastic anaemia, was successfully transfused with random donor platelets during 13 months. The serum of this patient contained only granulocyte-and mononuclear-cell-reactive antibodies, but no platelet-reactive antibodies. A nearly normal survival time of the donor platelets as well as a prolonged rejection time of a skin allograft of the same donor support the serological findings. The 51Cr-platelet survival time was not influenced by a leucocyte concentrate from the same donor, which was administered at the same time. Thus, in our patient, no increased platelet destruction could be induced via the so-called innocent bystander mechanism.
D000741:Anemia, Aplastic / Q000276:immunology / Q000628:therapy; D001792:Blood Platelets / Q000276:immunology* / Q000378:metabolism; D002470:Cell Survival; D006084:Graft Rejection; D006650:Histocompatibility Testing; D006801:Humans; D007108:Immune Tolerance; D007518:Isoantibodies / Q000096:biosynthesis; D008297:Male; D017713:Platelet Transfusion; D016038:Skin Transplantation
D007518:Isoantibodies