Disseminated aspergillosis treated with amphotericin B and surgery in a boy with chronic granulomatous disease.
A case of systemic infection caused by Aspergillus fumigatus in a seven-year-old boy suffering from chronic granulomatous disease is described. The fungus had infiltrated his lungs, his left foot and the popliteal and inguinal lymph nodes. Amphotericin B, 1 mg/kg daily, was given for three months via a central venous catheter, Progressive anaemia made amputation of his left leg necessary. The bone tissue was heavily infiltrated with fungal elements. The regional lymph nodes were also resected because of fungal growth. After six months no fungi were found in liver aspirates taken on account of liver abscesses due to Staphylococcus aureus. The combined medical and surgical approach resulted in complete eradication of the Aspergillus infection, as verified by the disappearance of Aspergillus precipitins.
D000666:Amphotericin B / Q000627:therapeutic use*; D000671:Amputation, Surgical; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D001232:Aspergillus fumigatus; D002648:Child; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D007866:Leg / Q000601:surgery*; D008297:Male
D000666:Amphotericin B