[Concentrations of erythromycin and amoxicillin in tonsil and sinus tissues of patients with tonsillitis and sinusitis. A comparison (author's transl)].
Thirty male patients with chronic tonsillitis and 30 male patients with chronic Sinusitis maxillaris were pre-treated for four days with either 2 X 1 g erythromycin daily per os or 3 X 0.75 g amoxicillin daily per os in an open and randomised comparative study. MIC values for the relevant bacteria were determined beforehand. The intended tonsillectomy or radical operation was performed on the third day of pre-treatment, circa 1.5 h after the final administration of antibiotics. The tonsils or the sinus membrane were examined bacteriologically; the concentrations of erythromycin or amoxicillin were determined. At the same time, the concentration of the antibiotic administered was determined in the serum. The average concentration of erythromycin in the tonsil tissue was 1.24 micrograms/g; it was 1.21 micrograms/g in the sinus membrane. Amoxicillin was found at a concentration of 0.17 microgram/g in the tonsil tissue, and 0.1 microgram/g in the sinus membrane. While the levels of erythromycin in the tissue generally equalled or exceeded the MIC value for the pathogen in question, the levels of amoxicillin only reached the relevant MIC value for the given pathogen in a few cases since the concentration in the tissue was insufficient. The clinical tolerance of both antibiotics was good.
D000284:Administration, Oral; D000658:Amoxicillin / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004917:Erythromycin / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D007700:Kinetics; D014066:Palatine Tonsil / Q000378:metabolism*; D010256:Paranasal Sinuses / Q000378:metabolism*; D012852:Sinusitis / Q000188:drug therapy*; D014069:Tonsillitis / Q000188:drug therapy*
D004917:Erythromycin; D000658:Amoxicillin
Vergleich von Erythromycin- und Amoxicillin-Konzentrationen im Tonsillen- und Sinusgewebe bei Patienten mit Tonsillitis und Sinusitis.