title: A third unlinked gene controlling the pyruvate dehydrogenase complex in Aspergillus nidulans.
abstract: Pyruvate dehydrogenase complex mutants of Aspergillus nidulans were obtained by ultraviolet treatment and enrichment procedures. Among 160 glycolytic mutants, 86 pyruvate dehydrogenase complex mutants (including some temperature-sensitive mutants) were found. In addition to genes pdhA and pdhB, which are described in previous studies, a third gene, pdhC, controlling the function of the enzyme complex, was identified. The three genes were not linked and were mapped in the following linkage groups: pdhA in group I, pdhB in group V, and pdhC in group VIII, where it was the first marker on the left arm.
mesh_terms: D001233:Aspergillus nidulans / Q000201:enzymology / Q000235:genetics*; D002874:Chromosome Mapping; D005796:Genes; D008040:Genetic Linkage; D006019:Glycolysis; D009154:Mutation; D011768:Pyruvate Dehydrogenase Complex / Q000235:genetics* / Q000378:metabolism
chemical_list: D011768:Pyruvate Dehydrogenase Complex