Renin participation in hypertension associated with unilateral hydronephrosis.
Renin-mediated hypertension can occur with unilateral renal obstruction and hydronephrosis. Elevated peripheral plasma renin activity and a lateralizing renal vein renin relationship represent a hormonal pattern suspiciously suggestive of a renovascular etiology. We report a case of surgically corrected renin-mediated hypertension secondary to ureteropelvic junction obstruction. Hyperreninemia associated with acute unilateral hydronephrosis probably occurs transiently to initiate chronic hypertension sustained by more complex volume-vasoconstriction abnormalities. The participation of renin in this hypertension seems to be influenced by the duration of the obstruction, the presence or absence of a contralateral normal kidney and other intrarenal factors.
D000328:Adult; D006801:Humans; D006869:Hydronephrosis / Q000209:etiology* / Q000378:metabolism; D006977:Hypertension, Renal / Q000209:etiology* / Q000378:metabolism; D008297:Male; D012083:Renin / Q000097:blood*; D014517:Ureteral Obstruction / Q000150:complications*
D012083:Renin