[The influence of indomethacin and possible role of prostaglandin on renal calcium excretion (author's transl)].
Our aim was to evaluate the possible role of prostaglandins (PG) on renal calcium excretion in humans through the PG inhibitory effects of indomethacin. Renal calcium excretion was evaluated by a technique of impulse analysis which gives a specific index of tubular calcium transport. Several parameters were derived from this specific transport function W(t): 1) the fractional excretion of filtered calcium as % of total dose (FECa % TD); 2) the peak excretion rate; 3) the mean transit time (MTT, min). The aforementioned parameters were determined in 7 healthy subjects in basal conditions and again after 10 days of treatment with 100 mg indomethacin daily. FECa was significantly (P less than 0.02) higher with indomethacin (8.18 +/- 0.97) than under basal conditions : (5.02 +/- 0.57). The peak excretion rate and MTT remained unchanged after indomethacin. These results indicate that indomethacin increases renal calcium excretion. As indomethacin did not produce any significant change in glomerular filtration rate (125 +/- 7 ml/min before v.s. 129 +/- 9 after) one can assume that PG play a role in tubular calcium reabsorption. However the mechanism remains to be elucidated : direct action of mediated through the cyclic AMP system.
D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D007457:Iodine Radioisotopes; D007483:Iothalamic Acid / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D007684:Kidney Tubules / Q000378:metabolism; D008875:Middle Aged; D011453:Prostaglandins / Q000502:physiology*
D002132:Calcium Radioisotopes; D007457:Iodine Radioisotopes; D011453:Prostaglandins; D007483:Iothalamic Acid; D002118:Calcium; D007213:Indomethacin
Effets de lindométacine et rôle possible des prostaglandines sur l'excrétion rénale du calcium.