'Nephrotoxicity' and metabolic acidosis in transplant patients on cyclosporin A.
Renal function, as represented by serum creatinine and creatinine clearance, 18 to 24 months after renal transplantation was studied in 21 patients receiving Cyclosporin A and compared with that of 25 patients on corticosteroids and azathioprine. Although renal function at six months post transplantation was significantly poorer in those patients on Cyclosporin A compared with those on conventional therapy, it did not deteriorate with time. No significant alteration in renal function was observed in five hepatic transplant recipients on Cyclosporin A after three months. Lower serum bicarbonate was observed more frequently in those renal transplant recipients on Cyclosporin A than in those on conventional therapy, reflecting possible tubular damage.
D000138:Acidosis / Q000097:blood / Q000139:chemically induced*; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D001639:Bicarbonates / Q000097:blood; D003404:Creatinine / Q000097:blood; D003524:Cyclosporins / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced*; D016030:Kidney Transplantation; D008297:Male; D011188:Potassium / Q000097:blood
D000305:Adrenal Cortex Hormones; D001639:Bicarbonates; D003524:Cyclosporins; D003404:Creatinine; D001379:Azathioprine; D011188:Potassium