Ibuprofen and diflunisal in rheumatoid arthritis: a double-blind comparative trial.
Both diflunisal (750 mg/day) and ibuprofen (1600 mg/day) were shown to be superior to placebo in the treatment of rheumatoid arthritis in a double-blind cross-over trial. Neither drug affected lymphocyte transformation to plant mitogens. Diflunisal scored better than ibuprofen at the dose levels chosen but the differences did not reach significance.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D004061:Diflunisal / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use*; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D011897:Random Allocation; D012459:Salicylates / Q000627:therapeutic use*
D012459:Salicylates; D004061:Diflunisal; D007052:Ibuprofen