Human Ia-like antigens (Analysis of the tissue distribution and immunochemical profile with monoclonal antibodies).
Analysis of the tissue distribution of human Ia-like antigens has shown that they have a wider distribution than originally reported. Furthermore, the expression of Ia-like antigens may change when cells undergo malignant transformation: for instance, melanoma cells acquire Ia-like antigens, while breast carcinoma cells lose them. Serological and immunochemical analysis of Ia-like antigens with monoclonal antibodies has shown a cellular and molecular heterogeneity of these molecules which had not been previously recognized with conventional allo- and xenoantisera. The functional significance of this heterogeneity is not known. Monoclonal antibodies to human Ia-like antigens cross-react with lymphocytes from other animal species indicating that portions of the molecules have been conserved during evolution. The biological implications of these findings are discussed.
D000818:Animals; D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D005455:Fluorescent Antibody Technique; D006681:HLA-D Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D009369:Neoplasms / Q000276:immunology
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D006681:HLA-D Antigens; D000949:Histocompatibility Antigens Class II