[Protective antigen of the pseudotuberculosis microbe].
Proteinolipopolysaccharide (PLPS) isolated from the causative agent of pseudotuberculosis has the properties of a protective antigen. It protects 86-90% of mice and guinea-pigs from lethal Y. pseudotuberculosis infection (20 lethal doses) and stimulates humoral and cellular immunity factors, as well as the phagocytic activity of monocytes. It is of particular importance due to the fact that in Y. pseudotuberculosis infection the system of mononuclear phagocytes plays a significant role in eliminating the causative agent from the body. The further study of PLPS with the aim of developing prophylactic preparations shows good promise.
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology; D006168:Guinea Pigs; D006824:Hybridization, Genetic; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008814:Mice, Inbred NZB; D014611:Vaccination; D015007:Yersinia / Q000276:immunology*; D015009:Yersinia Infections / Q000517:prevention & control*; D015012:Yersinia pseudotuberculosis Infections / Q000517:prevention & control*
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D008070:Lipopolysaccharides
Protektivnyĭ antigen psevdotuberkuleznogo mikroba.