In vitro augmentation of human natural killer (NK) cell activity by a streptococcal preparation OK-432 and its extracts, protein M and polysaccharides.
Effect of a streptococcal preparation OK-432 and its derivatives on the augmentation of human natural killer cell activity in vitro was examined. The strong augmentation was found by the OK-432 stimulation. Cell separation procedures revealed that cytotoxic activity augmented by the stimulant was considered to be mediated mainly by nonadherent, nonphagocytic, IgG-Fc receptor positive, non-T cells, i.e. NK cells. In addition, supernates cultured with OK-432 augmented NK activity, suggesting some kinds of soluble factors released in the supernates may be participating on the augmentation of human NK activity by OK-432.
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins / Q000494:pharmacology*; D001688:Biological Products / Q000494:pharmacology*; D002352:Carrier Proteins; D002469:Cell Separation; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D008264:Macrophages / Q000276:immunology; D009000:Monocytes / Q000276:immunology; D010844:Picibanil / Q000031:analogs & derivatives / Q000494:pharmacology*; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D013205:Staphylococcal Protein A / Q000494:pharmacology; D013297:Streptococcus pyogenes
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D001688:Biological Products; D002352:Carrier Proteins; D011135:Polysaccharides, Bacterial; D013205:Staphylococcal Protein A; C014689:streptococcal M protein; D010844:Picibanil