title: Deposition of IgA-dominant immune-complexes in muscular vessels from patients with IgA nephropathy.
abstract: The emergence of immunoglobulin depositions in muscular vessels from patients with IgA nephropathy was examined to determine whether the pathogenesis of IgA nephropathy was mediated by circulating IgA-dominant immune-complexes. Muscle biopsy specimens were obtained from the right flank at the same time of modified open renal biopsy. These biopsy samples were stained with fluorescein-conjugated anti human IgG, IgA, IgM, IgE, and C3 antisera. It was demonstrated that the depositions of IgA and/or C3 were observed in muscular vessels from some patients with IgA nephropathy. It is indicated that IgA nephropathy might be mediated by circulating IgA-dominant immune-complexes.
mesh_terms: D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis*; D001808:Blood Vessels / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007136:Immunoglobulins / Q000032:analysis; D007668:Kidney / Q000276:immunology; D007674:Kidney Diseases / Q000276:immunology*; D007678:Kidney Glomerulus / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000098:blood supply*
chemical_list: D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007136:Immunoglobulins