4-Chloromethylbiphenyl (4CMB), benzyl chloride (BC) and 4-hydroxymethylbiphenyl (4HMB): an evaluation of their mutagenic potential using Salmonella typhimurium.
The 3 compounds 4CMB, BC and 4HMB were tested using the "Ames' Salmonella assay. 4CMB produced a strong mutagenic response; no evidence of mutagenic activity was obtained with BC and 4HMB. Urine from mice treated with the 3 compounds was also tested. None of the urine samples produced a mutagenic response.
D000818:Animals; D001711:Biotransformation; D001713:Biphenyl Compounds / Q000494:pharmacology*; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D012486:Salmonella typhimurium / Q000187:drug effects; D013045:Species Specificity; D013329:Structure-Activity Relationship
D001713:Biphenyl Compounds; D009153:Mutagens; C033488:4-hydroxymethylbiphenyl; C033487:4-chloromethylbiphenyl