Ovulation induced by a gonadotropin releasing hormone analog in hypophysectomized rats involves prostaglandins.
A potent analogue of gonadotropin releasing hormone [D-Ala6- Des-Gly10-NH2]-GnRH ethylamide (GnRHa) caused oocyte maturation and ovulation when injected in the afternoon of proestrus in immature PMSG-treated female rats, hypophysectomized on the morning of proestrus. This action of GnRHa was accompanied by a marked increase in ovarian PGE levels. Furthermore, the pretreatment of the animals with a prostaglandin synthetase inhibitor (indomethacin) completely inhibited this PGE increase and ovulation. These data suggest a role for prostaglandins in GnRHa induced ovulation.
D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D006064:Gonadotropins, Equine / Q000494:pharmacology; D006728:Hormones / Q000494:pharmacology*; D007016:Hypophysectomy; D007213:Indomethacin / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000494:pharmacology; D008540:Meiosis / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000187:drug effects / Q000502:physiology
D006064:Gonadotropins, Equine; D006728:Hormones; D007987:Gonadotropin-Releasing Hormone; C010661:surfagon; D007986:Luteinizing Hormone; D007213:Indomethacin