Penetration of lymecycline (tetracycline) into the tissues of the Fallopian tube.
On the basis of a comparison of different methods used to determine the concentration of active lymecycline in Fallopian tube tissue, a method was adopted which allowed the determination of lymecycline in serosa and mucosa tissue of the Fallopian tube in 16 women undergoing hysterectomy. A difference in the concentration of active drug was found in serosa (greater than 1.7 mg/kg tissue) and mucosa (greater than 0.8 mg/kg tissue) in 16 patients on lymecycline therapy for 24 hours. These figures were fairly constant for the 7.5 hours following the administration. The figures are discussed in relation to the MIC values of the commonly found microorganisms in salpingitis.
D000328:Adult; D005187:Fallopian Tubes / Q000032:analysis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008194:Lymecycline / Q000378:metabolism*; D008828:Microbiological Techniques; D008875:Middle Aged; D009092:Mucous Membrane / Q000378:metabolism; D013754:Tetracyclines / Q000378:metabolism*
D013754:Tetracyclines; D008194:Lymecycline