Comparison of the combination of cholestyramine/alginates with placebo in the treatment of postgastrectomy biliary reflux gastritis.
Postgastrectomy biliary reflux gastritis is quite common. Several drugs have been used in its treatment, including the bile acid-binding resin cholestyramine, which seemed ineffective, possibly because of its rapid disappearance from the gastric remnant. It was suggested that by using alginates, which form a raft floating on the gastric contents, cholestyramine would be retained in the stomach for a longer period. 32 patients received either placebo or cholestyramine/alginates/bicarbonate (CAB). Gastroscopy with biopsies, laboratory studies and physical examination were performed before and after the trial. A two week intervals patients were interviewed about the effect on symptoms. A detailed Y-ray study was made of 5 patients, in which a series of pictures was taken after ingestion either of placebo or CAB together with a novel contrast medium. There was no statistical difference between treatment groups with respect to symptoms, gastroscopy or histological findings, nor did the X-ray study show any difference in retention time between placebo and CAB.
D000328:Adult; D000368:Aged; D000464:Alginates / Q000008:administration & dosage* / Q000627:therapeutic use; D001655:Bile Reflux / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D001660:Biliary Tract Diseases / Q000188:drug therapy*; D001706:Biopsy; D002792:Cholestyramine Resin / Q000008:administration & dosage* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects*; D005756:Gastritis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D011897:Random Allocation; D013270:Stomach / Q000473:pathology
D000464:Alginates; D004338:Drug Combinations; D002792:Cholestyramine Resin