Experimental induction of Proteus mirabilis cystitis in the pony and evaluation of therapy with trimethoprim-sulfadiazine.
Proteus mirabilis cystitis was induced in 9 ponies by chemically eroding the bladder mucosa before the organism was inoculated. Comparisons were made in the treatment of P mirabilis cystitis between ponies treated daily for 13 days with a trimethoprim-sulfadiazine (TMP-SDZ) paste and both positive and negative controls. Urine cultures from ponies treated with TMP-SDZ became negative for P mirabilis between days 3 and 9 after the start of the treatment, whereas positive controls remained infected until day 13. Urine cultures from all ponies were negative for P mirabilis on day 28. Urine concentrations of TMP and SDZ were relatively high after day 1 of therapy.
D000284:Administration, Oral; D000818:Animals; D003556:Cystitis / Q000188:drug therapy / Q000662:veterinary*; D004338:Drug Combinations; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D009582:Nitrofurantoin / Q000627:therapeutic use; D011512:Proteus Infections / Q000188:drug therapy / Q000662:veterinary*; D011513:Proteus mirabilis; D013411:Sulfadiazine / Q000627:therapeutic use*; D014295:Trimethoprim / Q000627:therapeutic use*
D004338:Drug Combinations; D013411:Sulfadiazine; D009582:Nitrofurantoin; D014295:Trimethoprim