Propranolol in schizophrenia. I. Comparison of propranolol, chlorpromazine and placebo.
Fifty-three hospitalized chronic schizophrenic patients were treated with either propranolol, chlorpromazine or placebo in a double-blind randomized trials for up to three months. Propranolol in a usual dose of 640 mg/day, produced marked cardiovascular effects but no improvement in schizophrenic symptomatology relative to placebo. The effects of chlorpromazine were small and inconsistent.
D001794:Blood Pressure / Q000187:drug effects; D002746:Chlorpromazine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use*; D011674:Pulse / Q000187:drug effects; D011897:Random Allocation; D012559:Schizophrenia / Q000188:drug therapy*
D011433:Propranolol; D002746:Chlorpromazine