title: Variability of anti-GBM binding in hereditary nephritis.
abstract: Anti-GBM staining by indirect immunofluorescence microscopy was performed on renal biopsies from 64 patients with a variety of diseases in which no in vivo bound immunoglobulin or complement components were identified by direct immunofluorescence microscopy. The glomeruli of all of the entities examined bound anti-GBM antibodies except for four of nine cases of hereditary nephritis of the Alport-type. The absence of anti-GBM staining was found to correlate with the severity of GBM splitting identified by electron microscopy.
mesh_terms: D000293:Adolescent; D000328:Adult; D001485:Basement Membrane / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005455:Fluorescent Antibody Technique; D008040:Genetic Linkage; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology* / Q000648:ultrastructure; D008297:Male; D009394:Nephritis, Hereditary / Q000235:genetics / Q000276:immunology*; D012737:Sex Factors; D014960:X Chromosome