Ontogeny of murine I-Ak antigens in tissue of nonlymphoid origin.
The ontogeny of I-Ak antigens in murine tissues of nonlymphoid origin has been evaluated by reacting acetone-fixed cryostat sections of embryonic, neonate, and adult tissues with the MOAb 10-2.16 in indirect immunofluorescence. Thymus dendritic cells appear to be the first to express I-Ak antigens which become detectable only after birth in skin Langerhans cells, gastrointestinal epithelium, septal cells in lung alveoli, and some endothelia. The full expression of I-Ak antigens as detected in adult mice is reached only at 1 month of age.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D004622:Embryo, Mammalian / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H / Q000196:embryology; D008810:Mice, Inbred C57BL / Q000196:embryology; D008811:Mice, Inbred DBA / Q000196:embryology; D011247:Pregnancy; D013997:Time Factors; D014018:Tissue Distribution
D000949:Histocompatibility Antigens Class II