Colchicine affects the distribution of isotope-labeled H2O and extracellular markers in rat liver and hepatomas.
Treatment of hepatoma-bearing rats with colchicine (175 or 250 micrograms/100 g body wt) greatly diminished the radioactivity in tumors when measured 10 min after subcutaneous injection of 3H2O. There were relatively small effects of colchicine treatment on the level of radioactivity in blood and little change in the ratio of radioactivity in blood and liver. Inhibitory effects of colchicine were also observed for the distribution in hepatomas of the extracellular markers [3H] methoxy-inulin and [14C] sucrose. An effect of colchicine on circulation in hepatomas may be a factor in the previously reported inhibitory action on metabolite uptake.
D000818:Animals; D003078:Colchicine / Q000097:blood / Q000494:pharmacology*; D005260:Female; D007328:Insulin / Q000031:analogs & derivatives / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000098:blood supply / Q000378:metabolism*; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D011915:Rats, Inbred BUF; D013395:Sucrose / Q000378:metabolism; D014867:Water / Q000378:metabolism*
D007328:Insulin; D014867:Water; C033739:insulin, methoxy-; D013395:Sucrose; D003078:Colchicine