[Effect of salt on the functional state of the renin-angiotensin-aldosterone system in healthy persons and hypertensives].
A total of 16 normal subjects and 30 patients with IB (labile hypertension) and IIB (stable hypertension) stages of essential hypertension during excessive salt intake as well as 13 normal persons and 43 patients at the labile and stable stages of essential hypertension on usual salt diet were examined. Renin activity, plasma aldosterone and cortisol levels were studied using radioimmunoassay in the basal conditions and 1 and 5 hours later after intravenous administration of 5% saline solution (3,6-3,8 mu mole of sodium (1 kg body mass). It was demonstrated that the prolonged excessive intake of sodium hydrochloride resulted in the alteration of the functional state of the renin-angiotensin-aldosterone system even in the normal persons. The above alterations are characterized by the loss of the adequate response of the renin-angiotensin system and the adrenal cortex to the increased sodium concentration, and extracellular fluid volume in the body, as well as by the separation of the functions of these two humoral systems.
D000293:Adolescent; D000328:Adult; D000450:Aldosterone / Q000097:blood; D004231:Diuresis / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension / Q000503:physiopathology*; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects*; D012965:Sodium Chloride / Q000494:pharmacology*; D013997:Time Factors
D012965:Sodium Chloride; D000450:Aldosterone; D012083:Renin; D006854:Hydrocortisone
Vliianie soli na funktsional'noe sostoianie renin-angiotenzin-al'dosteronovoĭ sistemy u zdorovykh i bol'nykh gipertonicheskoĭ bolezn'iu.