title: Role of H2-receptors in gastrogenic hyperglycemia and hyperinsulinemia in dogs.
abstract: Recent studies have demonstrated that an acidified liver meal stimulates insulin release and raises plasma glucose levels. To examine the mechanism of these changes, a liver extract test meal at either pH 7 or at pH 2 was instilled into the stomach of dogs with a bisected pylorus and a gastric fistula during the infusion of either cimetidine, a specific H2-receptor antagonist, or a saline control. In response to the meal at pH 2 insulin, glucagon and glucose levels rose significantly and were not significantly changed by the infusion of cimetidine. In response to the liver meal at pH 7 a late rise in plasma glucagon levels was observed while plasma insulin and glucose did not change significantly; however, during the infusion of cimetidine a significant rise in plasma insulin and glucose levels occurred. The present data suggest that H2-receptors participate in an inhibitory mechanism with respect to the insulin and glucose response during the gastric phase of a neutral meal, but they do not seem to be involved in the rise in insulin and glucose observed in response to an acidified gastric meal.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002927:Cimetidine / Q000494:pharmacology; D004285:Dogs; D005934:Glucagon / Q000097:blood; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000097:blood*; D008110:Liver Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D011968:Receptors, Histamine / Q000502:physiology*; D011970:Receptors, Histamine H2 / Q000502:physiology*; D013270:Stomach
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008110:Liver Extracts; D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D002927:Cimetidine; D005934:Glucagon