title: [Combined captopril and labetalol treatment of malignant arterial hypertension (author's transl)].
abstract: Five patients with malignant arterial hypertension and terminal (3) or advanced (2) renal failure were treated with the alpha-beta blocker labetalol and the angiotensin-converting enzyme inhibitor captopril. Labetalol alone or in combination with other antihypertensive agents had been ineffective in two cases and captopril alone in one; yet hypertension was rapidly controlled when the two drugs were given together. The return of blood pressure to normal levels brought about regression of digitalis-resistant cardiac failure in 2 patients and slight improvement of renal function in 2 other patients. The captopril-labetalol combination probably has a synergistic effect, and although its mechanism remains obscure this effect may be used to treat patients with severe or malignant arterial hypertension.
mesh_terms: D000328:Adult; D002216:Captopril / Q000627:therapeutic use*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D006333:Heart Failure / Q000150:complications; D006801:Humans; D006974:Hypertension, Malignant / Q000188:drug therapy*; D007676:Kidney Failure, Chronic / Q000150:complications; D007741:Labetalol / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011392:Proline / Q000031:analogs & derivatives*
chemical_list: D004983:Ethanolamines; D011392:Proline; D002216:Captopril; D007741:Labetalol
vernacular_title: Traitement de l'hypertension artérielle maligne par l'association captopril et labétalol.