Modulation by glucose and D-glyceraldehyde of glucagon and insulin secretion in the isolated perfused streptozotocin-treated rat pancreas.
In order to compare the effects of D-glyceraldehyde or glucose on glucagon secretion in insulin deficiency, the isolated streptozotocin-treated rat pancreas was perfused with arginine alone and arginine plus eigher glucose or D-glyceraldehyde. The glucagon secretion induced by arginine alone was not modified by pretreatment with streptozotocin, but the glucagon secretion induced by arginine plus either glucose or D-glyceraldehyde was less inhibited in the streptozotocin-treated pancreas. We conclude, therefore, that insulin deficiency may interfere with the metabolism of D-glyceraldehyde as well as glucose in the pancreatic A-cells, thus interfering with the inhibitory effect of glucose and D-glyceraldehyde of glucagon secretion.
D000818:Animals; D001120:Arginine / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005934:Glucagon / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology*; D005985:Glyceraldehyde / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D005985:Glyceraldehyde; D005934:Glucagon; D001120:Arginine; D005947:Glucose