The use of doxapram in the prevention of postoperative pulmonary complications.
A prospective, double-blind, randomized controlled clinical trial has been conducted to assess the effect of doxapram hydrochloride infusions on pulmonary complications in patients undergoing extensive abdominal operations. For the purposes of this study, a pulmonary complication was defined as the production of purulent sputum or the presence of any abnormal clinical or roentgenologic chest signs. Of the 53 control patients, 41 had chest problems develop by these criteria, whereas the same was true of only 20 of the 40 patients receiving doxapram. The average duration of hospitalization was one day less for those receiving the drug.
D002986:Clinical Trials as Topic; D004315:Doxapram / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000517:prevention & control*; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control; D011446:Prospective Studies; D011897:Random Allocation
D004315:Doxapram