[Influence of the venous wall--platelet interaction by dihydroergotamine (author's transl)].
The incubation of rabbit venous rings (vena cava) is followed by the synthesis and release of prostacyclin (prostaglandin I2, PGI2), as measured by the inhibition of ADP-induced platelet aggregation. The incubation of the venous rings in dihydroergotamine leads to a stimulation of PGI2 synthesis and/or release. This effect of dihydroergotamine, apart from the vasoactive properties of this compound, might prove advantageous as a prophylactic measure in venous thrombosis.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D004087:Dihydroergotamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000096:biosynthesis; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D014682:Vena Cava, Inferior / Q000187:drug effects* / Q000378:metabolism
D004087:Dihydroergotamine; D000244:Adenosine Diphosphate; D011464:Epoprostenol
Beeinflussung der Venenwand-Thrombozyten-interaktion durch Dihydroergotamin.