Evidence for two species of insulin-like growth factor II (IGF II and "big" IGF II) in human spinal fluid.
Human serum contains the somatomedins, insulin-like growth factor I and II (IGF I and II). In spinal fluid, however, only IGF II was found in measurable and significant amounts. In addition, an IGF II of larger mass could be detected by a radioimmunoassay for IGF II. This "big" IGF II is biologically active and has an apparent molecular weight of 9000.
D006801:Humans; D007328:Insulin / Q000097:blood / Q000134:cerebrospinal fluid*; D008970:Molecular Weight; D010455:Peptides / Q000097:blood / Q000134:cerebrospinal fluid*; D011863:Radioimmunoassay; D012016:Reference Values; D013002:Somatomedins / Q000097:blood / Q000134:cerebrospinal fluid*
D007328:Insulin; D010455:Peptides; D013002:Somatomedins