title: Multiple drug abuse involving nonopiate, nonalcoholic substances. II. Physical damage, long-term psychological effects and treatment approaches and success.
abstract: A review of the literature of multiple drug abuse involving two or more drug categories where at least one is a nonopiate, nonalcoholic substance (MDA NONA) suggested the possibility that sedative-hypnotics were the culpable agent for neuropsychological deficits in this group. Individually, amphetamines and hallucinogens, primarily LSD, have been associated with long-term psychological disturbance. While many abusers of these drugs who develop psychoses have been documented to be emotionally disturbed prior to drug usage, indicating that the drug exacerbated a prepsychotic condition, other abusers have no such history, indicating a drug-induced psychosis. Current treatment approaches appear to be ineffective for MDA-NONA abusers, as indicated by poor retention rates and relapse to drug use.
mesh_terms: D000662:Amphetamines / Q000009:adverse effects; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001288:Attention / Q000187:drug effects; D001925:Brain Damage, Chronic / Q000139:chemically induced / Q000209:etiology*; D005500:Follow-Up Studies; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects; D000860:Hypoxia / Q000150:complications / Q000209:etiology; D008238:Lysergic Acid Diethylamide / Q000009:adverse effects; D008691:Methadone / Q000627:therapeutic use; D009048:Motor Skills / Q000187:drug effects; D011605:Psychoses, Substance-Induced / Q000209:etiology; D012112:Residential Facilities; D019966:Substance-Related Disorders / Q000150:complications* / Q000523:psychology / Q000628:therapy; D014652:Vascular Diseases / Q000139:chemically induced
chemical_list: D000662:Amphetamines; D006993:Hypnotics and Sedatives; D008238:Lysergic Acid Diethylamide; D008691:Methadone