title: Sialadenosis of the salivary glands of the head. Studies on the physiology and pathophysiology of parotid secretion.
abstract: Sialadenosis is a noninflammatory disease of the salivary glands of the head. It is observed in connection with endocrine disorders, malnutrition and neurologic diseases. The parotid glands are predominantly affected by a parenchymatous swelling. Based on morphologic and biochemical investigations it can be assumed that disorders of the gland's acinar protein secretion are responsible for sialadenosis. Changes in secretory behavior are caused by either excessive stimulation ('stimulatory proteodyschylia') or by inhibition of secretion ('inhibitory proteodyschylia'). The origin of these secretory disorders is very likely to be found in the vegetative nerve system. The pathophysiology of sialadenosis can therefore only be understood after elucidation of the physiologic mechanisms of salivary gland secretion. Research in the field of biophysical and biochemical principles underlying parotid secretion has made considerable progress in recent years. A comprehensive review of this new evidence is necessary for the understanding of experimental studies on the pathogenesis of sialadenosis.
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D010305:Parotid Diseases / Q000150:complications; D010306:Parotid Gland / Q000187:drug effects / Q000294:innervation / Q000378:metabolism*; D051381:Rats; D012466:Salivary Gland Diseases / Q000209:etiology / Q000503:physiopathology*; D012471:Salivary Proteins and Peptides / Q000032:analysis; D013565:Sympatholytics / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology; D000516:alpha-Amylases / Q000378:metabolism
chemical_list: D012471:Salivary Proteins and Peptides; D013565:Sympatholytics; D013566:Sympathomimetics; D000516:alpha-Amylases