Regulation of granulopoiesis and distribution of granulocytes in early phase of bacterial infection.
Studies have been carried out to determine the effect of bacterial infection on CSF production, CFU-C activation, and bacterial clearance by mature granulocytes in mice infected with Escherichia coli. These studies have shown that immediately after bacterial infection (5 minutes), serum colony-stimulating factor (CSF) levels and bone marrow colony-forming units in culture (CFU-C) levels are elevated. This is followed by oscillatory rises in both of these parameters and the appearance of granulocytes in the infected site. With clearance of bacteria, CSF and CFU-C levels return to normal. These studies have indicated further that bacterial infection is a major stimulus for granulocyte production through the CSF-CFU-C system and that clearance of bacteria by mature granulocytes may serve as a negative feedback regulatory arm.
D000818:Animals; D002465:Cell Movement; D003114:Colony-Forming Units Assay; D003115:Colony-Stimulating Factors / Q000032:analysis; D004927:Escherichia coli Infections / Q000276:immunology / Q000503:physiopathology*; D006098:Granulocytes / Q000502:physiology*; D006410:Hematopoiesis; D007958:Leukocyte Count; D008297:Male; D051379:Mice
D003115:Colony-Stimulating Factors