[Experimental analysis of the pathophysiological significance of the "diabetogenic factor" present in the blood of animals with alloxan diabetes].
Hyperglycemia, induced by the disorder of Langerhans' islet structure and function, and hyperuricemia caused by purine metabolism pathological changes, appeared in the animals with experimental diabetes provoked by a single alloxan injection. As a result, endogenous alloxan-like factor, forming chronic diabetogenic background in the organism, arises and persists in the blood of the animals tested. Under these conditions, heparin exerts preventive and therapeutic effects due to alloxan or endogenous alloxan-like factor binding into complexes devoid of toxic activity.
D000496:Alloxan / Q000097:blood*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000209:etiology*; D006493:Heparin / Q000627:therapeutic use; D006943:Hyperglycemia / Q000209:etiology / Q000517:prevention & control; D007515:Islets of Langerhans / Q000503:physiopathology; D008297:Male; D051381:Rats; D014527:Uric Acid / Q000097:blood
D014527:Uric Acid; D000496:Alloxan; D006493:Heparin
Eksperimental'nyĭ analiz patofiziologicheskogo znacheniia "diabetogennogo" faktora, prisutstvuiushchego v krovi zhivotnykh pri alloksanovom diabete.