title: Prt-4 and Prt-5: new constituents of a gene cluster on chromosome 7 coding for esterproteases in the submandibular gland of the house mouse (Mus musculus).
abstract: The heredity and linkage of gene loci were established for two different enzymes with esterproteolytic activity from mouse submandibular gland: protease A and protease E. Based upon strain distribution and biochemical properties of the two esterproteases, the existence of two corresponding structural loci is proposed: Prt-4 (protease A) and Prt-5 (protease E). Prt-4 and Prt-5 proved to be different from Tam-1. From a four-point-cross, the gene order Gpi-1-(Tam-1, Prt-4, Prt-5)-c is suggested. Thus a gene cluster was shown to exist on chromosome 7 coding for esterproteases, all of which are controlled by testosterone.
mesh_terms: D000483:Alleles; D000818:Animals; D004790:Enzyme Induction; D005260:Female; D008040:Genetic Linkage; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010447:Peptide Hydrolases / Q000235:genetics*; D010641:Phenotype; D013045:Species Specificity; D013363:Submandibular Gland / Q000201:enzymology*; D013739:Testosterone / Q000494:pharmacology
chemical_list: D013739:Testosterone; D010447:Peptide Hydrolases