Heparin treatment of deep vein thrombosis. Effects and complications after continuous or intermittent heparin administration.
Twenty-eight patients with the diagnosis of deep vein thrombosis (DVT) were subjected to a prospective, randomized study comparing continuous and intermittent heparin treatment, utilizing the same doses and duration of therapy. The effect on pain (estimated with a scoring system) and the antithrombotic effect (assessed by the inhibition of 125I-fibrinogen accretion), followed for one week, were unrelated. Pulmonary embolism was scored and studied from lung perfusion scans and chest X-rays. A high frequency was found in both groups. The therapeutic efficacy and side-effects did not differ between the two treatment groups. Bleeding, preferentially from vein puncture (post-phlebography), was more common in women, while a heparin-induced elevation of serum aminotransferases (S-ALAT adn S-ASAT) (in 2/3 of the patients) was not related to age, sex or bleeding complications.
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006470:Hemorrhage / Q000139:chemically induced; D006493:Heparin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000517:prevention & control; D011897:Random Allocation; D013924:Thrombophlebitis / Q000188:drug therapy*; D000637:Transaminases / Q000097:blood
D005340:Fibrinogen; D006493:Heparin; D000637:Transaminases