Nifedipine in medically refractory angina pectoris.
Nifedipine was administered to 21 patients with angina pectoris which was refractory to conventional medication. In no case had coronary artery spasm been demonstrated. The condition of 13 patients (62%) improved with nifedipine, and eight patients (38%) had a long-term response. Nitrate-type side effects were reported by seven patients (33%), all of whom were being treated concurrently with isosorbide dinitrate. We conclude that nifedipine is a promising drug in the management of angina pectoris, even in the absence of documented coronary spasm.
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D000792:Angiography; D002986:Clinical Trials as Topic; D003971:Diastole / Q000187:drug effects; D004244:Dizziness / Q000139:chemically induced; D005260:Female; D006261:Headache / Q000139:chemically induced; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D010865:Pilot Projects; D011725:Pyridines / Q000627:therapeutic use*
D011725:Pyridines; D009543:Nifedipine