The effect of terbutaline sulphate on exercise-induced asthma in children.
Terbutaline sulphate (Bricanyl; Keatings) aerosol or placebo aerosol was administered in a randomized fashion to 26 asthmatic children with proven exercise-induced asthma. The children were then subjected to the modified standard exercise challenge test involving running on the level for 6 minutes. Terbutaline sulphate aerosol had a marked protective effect against exercise-induced asthma in these children. Compared with placebo, a significant reduction in exercise-induced bronchospasm was achieved. The improved design of the mouthpiece, incorporating a newly introduced 'misting tube' enabled the children to handle the apparatus easily. The need to synchronize the activation of the aerosol with inhalation was eliminated. Terbutaline aerosol can be recommended to protect children affected by exercise-induced asthma. The preparation can be given prior to the exercise challenge and will offer prolonged and adequate protection against exercise asthma.
D000336:Aerosols; D001249:Asthma / Q000188:drug therapy*; D001250:Asthma, Exercise-Induced / Q000188:drug therapy*; D002648:Child; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D010366:Peak Expiratory Flow Rate; D013726:Terbutaline / Q000008:administration & dosage* / Q000627:therapeutic use
D000336:Aerosols; D013726:Terbutaline