[Clinical trial of isaxonine in the ulcerous mutilating acropathy of chronic alcoholics (author's transl)].
The ulcerous mutilating acropathy accompanying impairment of the peripheral nervous system, as evidenced by the electrophysiology of chronic alcoholics, formed the subject of a double-blind (isaxonine) survey carried out with a placebo in the case of such patients. The withdrawal of alcoholic beverages was a therapeutic rule in both groups. Healing of perforating plantar ulcers was clearly more frequent in the treated group than in the control group. The improvement was accompanied by an improvement in sensory disorders, particularly superficial tactile sensibility.
D000428:Alcohol Drinking; D000437:Alcoholism / Q000150:complications*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005534:Foot Diseases / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D011743:Pyrimidines / Q000009:adverse effects / Q000627:therapeutic use*; D012883:Skin Ulcer / Q000188:drug therapy* / Q000209:etiology
D011743:Pyrimidines; C020375:isaxonine
Essai clinique de l'isaxonine dans l'acropathie ulcéro-mutilante des alcooliques.