title: The effect of Damvar on the formation of hemopoietic splenic colonies in mice, and on the peripheral blood picture in rats and dogs.
abstract: The present paper deals with the effect of Damvar on hemopoiesis. The test of formation of hemopoietic splenic colonies (CFU-S) was used in mice, the peripheral blood picture and bone marrow differential after long-term administration of Damvar was tested in rats and dogs. The bone marrow cells from mice after a single dose of Damvar or cells incubated with Damvar in vitro showed no reduction of colony-forming activity. A single dose or repeated variable doses of Damvar, or combined administration of Damvar and Cyclophosphamide in some cases influenced the number of CFU-S in irradiated mice following transplantation of normal murine bone marrow cells. A number of CFU-S lower than 75% of the control count was never found. The application of Damvar to rats and dogs caused no significant changes in their blood pictures and bone marrows.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001853:Bone Marrow / Q000528:radiation effects; D016026:Bone Marrow Transplantation; D003114:Colony-Forming Units Assay; D004285:Dogs; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D051379:Mice; D011744:Pyrimidinones / Q000494:pharmacology*; D051381:Rats; D014184:Transplantation, Homologous
chemical_list: D000970:Antineoplastic Agents; D011744:Pyrimidinones; C019161:damvar