title: Steroidal actions and voluntary drinking of ethanol by male and female rats.
abstract: The effect of certain steroidal compounds with estrogenic and antiestrogenic properties on voluntary intake of ET by rats with preference to ET of both sexes was studied. The effect of a nonsteroidal antiandrogenic compound and its biologically active metabolite (SCH-16423) on these parameters was also evaluated. The observed behavioral drinking profile of ET was studied in conjunction with determination of L-ADH and L-ALDH as a function of drug treatment in both sexes. Acute administration of estrogenic compounds, estradiol and ethinyl estradiol, decreased voluntary drinking of ET by male and female rats, respectively. Short-term administration of the antiestrogenic compound TMX resulted in aversion to ET consumption in the male but not in the female rat. Acute administration of the SCH-16423 but not its parent nonsteroidal antiandrogen compound FL decreased ET drinking from predrug treatment. The biochemical results show an inhibitory action by the steroidal compound on hepatic L-M-ALDH with a lack of biochemical effect of FL and SCH-16423 on these enzymes. The results are discussed in conjunction with those available in literature to propose a hepatic-gonadal link in the preference to ET drinking and indicate that the underlying mechanism is probably related to the inhibitory action of estrogenic compounds used on L-M-ALDH.
mesh_terms: D000426:Alcohol Dehydrogenase; D000428:Alcohol Drinking / Q000187:drug effects*; D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000444:Aldehyde Dehydrogenase; D000445:Aldehyde Oxidoreductases / Q000378:metabolism; D000818:Animals; D004958:Estradiol / Q000494:pharmacology; D004965:Estrogen Antagonists / Q000494:pharmacology*; D004967:Estrogens / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D005485:Flutamide / Q000031:analogs & derivatives / Q000494:pharmacology; D008099:Liver / Q000201:enzymology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013629:Tamoxifen / Q000494:pharmacology
chemical_list: D004965:Estrogen Antagonists; D004967:Estrogens; D013629:Tamoxifen; C014290:hydroxyflutamide; D004997:Ethinyl Estradiol; D004958:Estradiol; D005485:Flutamide; D000429:Alcohol Oxidoreductases; D000426:Alcohol Dehydrogenase; D000445:Aldehyde Oxidoreductases; D000444:Aldehyde Dehydrogenase