title: Lipid peroxidation in alcoholic liver disease in humans.
abstract: The lipoperoxide level in liver as well as serum in alcoholic patients was measured by using the thiobarbituric acid method. Heavy drinkers with deposition of fat in liver had a significantly (p less than 0.001) higher level of hepatic lipoperoxide examined in about 7 days after abstinence than did nonalcoholic individuals with histologically normal liver. Of these heavy drinkers, cases with a remarkably high level of liver lipoperoxide showed a high incidence of hepatic cell necrosis. The hepatic lipoperoxide level was correlated with the serum lipoperoxide level in these heavy drinkers (r = 0.750, p less than 0.001). In chronic alcoholics, high levels of serum lipoperoxide were usually observed on admission, and a significant positive correlation was found between the serum lipoperoxide level and serum GOT activity (r = 0.541, p less than 0.01). After a 2-wk abstinence, the levels of serum lipoperoxide decreased, which was associated with improvement of liver function tests. These results suggest a possible involvement of lipid peroxidation in alcohol-induced liver damage in humans.
mesh_terms: D000328:Adult; D001219:Aspartate Aminotransferases / Q000097:blood; D002784:Cholesterol / Q000097:blood; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood / Q000378:metabolism*; D008108:Liver Diseases, Alcoholic / Q000378:metabolism*; D008297:Male; D014280:Triglycerides / Q000097:blood
chemical_list: D008054:Lipid Peroxides; D014280:Triglycerides; D002784:Cholesterol; D001219:Aspartate Aminotransferases