title: Collagen molecules comprised of alpha 1(V)-chains (B-chains): an apparent localization in the exocytoskeleton.
abstract: Antibodies specific for alpha 1(V) chains and native collagen molecules containing the alpha 1(V) chain have been used to study the localization of alpha 1(V)-containing molecules in differentiating hyaline cartilage. Immunofluorescence data show that the undifferentiated mesenchyme contains significant quantities of these molecules throughout the cell-rich tissue matrix. Examination of fully differentiated hyaline cartilage reveals a unique staining pattern wherein the immunofluorescent material is restricted to the pericellular matrix within the chondrocyte lacunae. We conclude from these data in conjunction with other evidence that the Type V collagens function as components of an exocytoskeleton for connective tissue cells.
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D002356:Cartilage / Q000648:ultrastructure; D002454:Cell Differentiation; D003094:Collagen / Q000276:immunology / Q000502:physiology*; D003238:Connective Tissue / Q000648:ultrastructure; D005455:Fluorescent Antibody Technique; D006801:Humans; D011817:Rabbits
chemical_list: D003094:Collagen