A comparative clinical study of dioxonium and pancuronium as muscle relaxants in small children.
Dioxonium (30, 40, and 60 microgram/kg i.v.), a new depolarizing agent, weas compared with pancuronium (0.05 and 0.1 mg/kg i.v.) as a muscle relaxant in combination anesthesia during general surgical operations in small children. Generally, the conditions during intubation, maintenance of anesthesia, and in the recovery room were comparable after both drugs. There were no differences in the cardiovascular responses either. However, a wider intra- and interindividual variation in the drug response was observed after dioxonium, especially after repeated administrations.
D000758:Anesthesia; D002319:Cardiovascular System / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004148:Dioxolanes / Q000494:pharmacology*; D004149:Dioxoles / Q000494:pharmacology*; D006801:Humans; D007223:Infant; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D010197:Pancuronium / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*
D004148:Dioxolanes; D004149:Dioxoles; D009466:Neuromuscular Blocking Agents; D011759:Pyrrolidines; C012938:dioxonium; D010197:Pancuronium