[Restoration of immune functions in T-cell depressed spontaneously hypertensive rats (SHR) by injection of neurotropin (author's transl)].
A strain of spontaneously hypertensive rats (SHR) showed a progressive decline in T-cell functions with aging. In order to restore the depressed immune functions, the effect of immunopotentiators such as Neurotropin, PS-K or thymus extract on immune responses of SHR was studied. The results presented here demonstrated that injection of Neurotropin completely restored the T-cell functions in SHR as detected by a rosette forming test, a plaque forming assay and blastogenesis. Administration of thymus extract also restored the immune functions except helper T-cell activity. However, administration of PS-K increased only numbers of rosetting cells in the thymus of SHR. Biological significance of Neurotropin as immunopotentiators was discussed.
D000276:Adjuvants, Immunologic; D000818:Animals; D006462:Hemolytic Plaque Technique; D006973:Hypertension / Q000276:immunology*; D008213:Lymphocyte Activation; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D000276:Adjuvants, Immunologic; D011134:Polysaccharides; C010491:neurotropin