title: The effect of bromocriptine (BCT) on the on-off phenomenon.
abstract: Twenty-three patients with idiopathic Parkinson disease with classic "on-off" phenomena were studied prospectively during treatment with bromocriptine (BCT). Patients were evaluated for an average of 6 to 12 months and received an average of 56.5 mg of BCT. Nine patients (39%) showed improvement in terms of "on-off". When evaluated retrospectively, it appeared that the only difference between the responders and non-responders was a younger mean age (57.1 to 63.2).
mesh_terms: D001971:Bromocriptine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D007980:Levodopa / Q000009:adverse effects* / Q000627:therapeutic use; D010300:Parkinson Disease / Q000188:drug therapy*
chemical_list: D001971:Bromocriptine; D007980:Levodopa