title: Localisation of immunoglobulin on the liver cell surface in primary biliary cirrhosis.
abstract: Direct immunofluorescence studies were performed on isolated liver cells in order to detect surface localisation of IgG in acute and chronic hepatitis and primary biliary cirrhosis. Membrane-bound IgG was demonstrated in nine patients. Six of eight patients with primary biliary cirrhosis showed granular fluorescence on their liver cell surfaces suggesting that an antibody or immune complex-mediated cytotoxicity might be involved in the pathogenesis of this disease.
mesh_terms: D002462:Cell Membrane / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006505:Hepatitis / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008099:Liver / Q000276:immunology*; D008105:Liver Cirrhosis, Biliary / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000032:analysis*
chemical_list: D007074:Immunoglobulin G; D011947:Receptors, Antigen, B-Cell