title: A new rat mutant with defective overhairs and spongy degeneration of the central nervous system: clinical and pathologic studies.
abstract: A new spontaneous autosomal recessive mutation with a nervous disorder and a hair anomaly occurred in a colony of Sprague Dawley rats. The animals developed a generalized body tremor at about 15 days of age, and with increasing age a progressive flaccid paresis occurred. Light microscopy revealed spongy changes in the central nervous system. The mutant was designated zitter rat (zi).
mesh_terms: D000818:Animals; D002493:Central Nervous System Diseases / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D005260:Female; D006197:Hair / Q000002:abnormalities*; D008297:Male; D009154:Mutation; D010375:Pedigree; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*; D011922:Rats, Mutant Strains / Q000235:genetics*; D012376:Rodent Diseases / Q000235:genetics* / Q000473:pathology