[Solubility of the polyene antibiotics nystatin and levorin in water-organic mixtures].
Solubility of the polyenic antibiotics levorin and nystatin in water-alcohol mixtures and in the water-acetone system was studied. Methanol, ethanol, n-propanol, isopropanol and n-butanol were used as alcohols. It was shown that the water-n-propanol system had the maximum dissolving properties with respect to levorin and nystatin. In the water-acetone system nystatin and levorin were maximally dissolved under 40 per cent of water and 60 per cent of acetone and 30 per cent of water and 70 per cent of acetone, respectively.
D000433:1-Propanol / Q000494:pharmacology; D000096:Acetone / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D000440:Butanols / Q000494:pharmacology; D002122:Calcium Chloride / Q000494:pharmacology; D002174:Candicidin / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology; D009761:Nystatin / Q000494:pharmacology*; D012995:Solubility; D014867:Water / Q000494:pharmacology
D000935:Antifungal Agents; D000440:Butanols; D014867:Water; D000096:Acetone; D009761:Nystatin; D002174:Candicidin; D000431:Ethanol; D000433:1-Propanol; D002122:Calcium Chloride
Rastvorimost' polienovykh antibiotikov nistatina i levorina v vodno-organicheskikh smesiakh.