Lack of carcinogenicity of DDT in hamsters.
Syrian golden hamsters were fed for their lifespan a diet containing 0, 125, 250 and 500 parts per million (ppm) of ddt. The incidence of tumour bearing animals was 13% among control females and ranged between 11-20% in treated females. In control males 8% had tumours. The incidence of tumour bearing animals among treated males ranged between 17-28%. The incidence of adrenal cortex tumours showed a dose-related increase among the DDT-treated males. A liver-cell tumour and 2 liver hemangioendotheliomas were observed in 3 males treated with 250 ppm DDT. No liver-cell tumours were observed in the controls. No significant difference in tumour incidence was observed in treated versus control Syrian golden hamsters.
D000310:Adrenal Gland Neoplasms / Q000139:chemically induced; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D006224:Cricetinae; D003634:DDT / Q000633:toxicity*; D005260:Female; D008099:Liver / Q000187:drug effects; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000139:chemically induced*
D003634:DDT