Pyridoxine reduces core body temperature in rats.
A mild hypothermia was produced in female rats during treatment with pyridoxine HCl (Vitamin B6), 100 mg/kg, administered in the drinking water. The hypothermic effect appeared by day 3 and persisted through 15 days of treatment. The reduction in core temperature was greater early in the day, just following the nocturnal period of maximum food and water consumption of the rat. Tail tendon temperatures of control and pyridoxine-treated animals showed no evidence of increased heat loss. Thus the hypothermia appears to reflect decreased heat production. The implications of a reduced metabolic rate for gerontological research are discussed.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D011736:Pyridoxine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D011736:Pyridoxine