Mutagenic activity of non-volatile organic matter associated with suspended matter in urban air.
Extracts of atmospheric suspended matter showed a direct mutagenic effect in the Ames test. This effect was increased by metabolic activation. These extracts were separated into an aliphatic, an aromatic and a polar fraction. The aliphatic fraction had no effect, with or without activation; the aromatic fraction showed the greatest mutagenicity with and without activation; the polar fraction was also mutagenic, but its metabolic activation did not enhance the effect. The active compounds in this last fraction could be represented in a significant part by oxygenated derivatives of polycyclic aromatic hydrocarbons.
D000388:Air / Q000032:analysis*; D000818:Animals; D001530:Belgium; D001711:Biotransformation; D006801:Humans; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000302:isolation & purification*; D009154:Mutation; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects; D014505:Urban Population
D009153:Mutagens