[Effect of gamma-aminobutyric acid on audiogenic seizures and conditioned reflexes in the rat].
The influence of GABA injection (intraperiotoneal) on the sensitivity to sound and behaviour was studied on KM line rats, in which a strong sound produces epileptiform seizures, and on sound-resistant Wistar line rats. It was shown that in the KM line rats the previously elaborated motor alimentary conditioned reflex was impaired for several hours after the seizures. The two first GABA injections to the rats of both lines reduce the number of adequate reactions to a signal stimulus. As GABA injections are repeated, conditioned activity is restored. A four-time GABA injection results in blocking of the audiogenic seizures in a number of rats of the KM line and in the maintenance of normal behaviour after the action of the epileptogenic stimulus.
D000161:Acoustic Stimulation; D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects* / Q000502:physiology; D004198:Disease Susceptibility; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology / Q000517:prevention & control*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology / Q000627:therapeutic use*
D005680:gamma-Aminobutyric Acid
Deĭstvie gamma-aminomaslianoĭ kisloty na audiogennye pripadki i uslovnye refleksy u krys.