title: Microenvironment of Woringer-Kolopp's disease.
abstract: A localized form of 'Pagetoid reticulosis' (Woringer-Kolopp's disease) is described morphologically. It can be shown that ultrastructurally the 'Pagetoid cells' are heterogenic and that different cell types can be distinguished: there are lymphoid cells, which often look like Lutzner cells, and nonlymphoid cells which can be characterized as indeterminate cells or Langerhans' cells. Often a close topographical relation between lymphoid and nonlymphoid cells can be demonstrated. This finding is suggestive for a functional interaction between the lymphoid cells, which are most probably T cells, and indeterminate cells and Langerhans' cells, which are known to be important for the thymus-dependent immune reaction. The presence of the nonlymphoid cell population in the epidermis in Woringer-Kolopp's disease seems to build up the specific microenvironment for lymphoid cell reaction.
mesh_terms: D004817:Epidermis / Q000201:enzymology / Q000648:ultrastructure*; D006801:Humans; D007801:Langerhans Cells / Q000201:enzymology / Q000648:ultrastructure; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000473:pathology; D012871:Skin Diseases / Q000201:enzymology / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology