Typing for RhLA-D in rhesus monkeys: II. Genetics of the D antigens and their association with DR antigens in a population of unrelated animals.
A population of 94 unrelated rhesus monkeys was typed for MLC antigens using 38 homozygous typing cells which define RhLA-D specificities. A genetic analysis showed that the ten D specificities are alleles of a single locus, the gene frequencies of which are in Hardy-Weinberg equilibrium. The association between the cellularly defined D and the serologically defined DR antigens in the population was usually high, confirming the close relationship between D and DR antigens. Two new associations were found, i.e. between the D-locus antigens 9 and 10 and the serologically defined B-cell antigens 109 and 101, respectively. This observation confirms prior speculations that the latter two antigens may belong to the DR series.
D000483:Alleles; D000818:Animals; D005787:Gene Frequency; D006649:Histocompatibility Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D008251:Macaca / Q000276:immunology*; D008253:Macaca mulatta / Q000276:immunology*
D006649:Histocompatibility Antigens