Paradoxical hypersecretion of growth hormone in patients with endometrial atypical hyperplasia and carcinoma. Effect of hysterectomy.
Paradoxical hypersecretion of human growth hormone (HGH) followed a glucose load in patients with endometrial cancer and atypical hyperplasia of the endometrium. All patients had normal fasting plasma glucose and serum HGH concentration with a normal glucose tolerance curve. Their urinary estrogen concentrations were within the normal postmenopausal range. 6 months after abdominal total hysterectomy and bilateral oophorectomy, the glucose load was repeated. Following surgery all patients showed a normal suppression of HGH secretion during the hyperglycemic period. These findings suggest the existence of a HGH-releasing factor in the neoplastic and preneoplastic endometrial tissue. This factor might be related to the abnormal HGH responses observed.
D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D004714:Endometrial Hyperplasia / Q000097:blood / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D011230:Precancerous Conditions / Q000503:physiopathology* / Q000601:surgery; D014594:Uterine Neoplasms / Q000097:blood / Q000503:physiopathology* / Q000601:surgery
D001786:Blood Glucose; D013006:Growth Hormone