Potential role of the A alpha chain in the binding of calcium to human fibrinogen.
The binding of Ca2+ to human fibrinogen was investigated. Molecules with intact A alpha chain possessed three high-affinity binding sites but fibrinogen samples with partially degraded A alpha chain exhibited only two sites. It is therefore suggested that the integrity of this chain is required for the interaction between the protein and this cation.
D001665:Binding Sites; D002118:Calcium / Q000378:metabolism*; D002413:Cations, Divalent; D004591:Electrophoresis, Polyacrylamide Gel; D005340:Fibrinogen / Q000302:isolation & purification / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding
D002413:Cations, Divalent; D005340:Fibrinogen; D002118:Calcium