Bronchoconstrictor effects of leukotriene C in humans.
Maximum expiratory flow rate at 30 percent of vital capacity above residual volume served as an index of airway obstruction in comparing the effects of leukotriene C and histamine administered by aerosol to five normal persons. Leukotriene C was 600 to 9500 times more potent than histamine on a molar basis in producing an equivalent decrement in the residual volume. The leukotriene C response was slow in onset and prolonged, reminiscent of the effects of aerosol allergen challenge in asthmatic allergic subjects.
D000328:Adult; D000403:Airway Resistance / Q000187:drug effects*; D001980:Bronchi / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011460:Prostaglandins F / Q000494:pharmacology; D013189:SRS-A / Q000494:pharmacology*; D013997:Time Factors
D011460:Prostaglandins F; D013189:SRS-A; D006632:Histamine