title: [Search for agents with prolonged anesthetizing action (the neurolytic type of local anesthetizing action)].
abstract: Compounds that possess long-term anesthetic effect have been found among phenylethylamine derivatives substituted by O-alkyl (position 4) or O-benzyl (positions 2, 3 and 4) radicals. It was shown that these compounds compare very favourably with novocain, since their anesthetic effect exceeds 54.8 - 66.9-fold that produced by novocain. Such an effect is a consequence of neurolytic properties of the compounds synthesized.
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D003692:Delayed-Action Preparations; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D008297:Male; D010627:Phenethylamines / Q000494:pharmacology; D011343:Procaine / Q000494:pharmacology; D011817:Rabbits; D013329:Structure-Activity Relationship; D013997:Time Factors
chemical_list: D000779:Anesthetics, Local; D003692:Delayed-Action Preparations; D010627:Phenethylamines; D011343:Procaine
vernacular_title: Izyskanie sredstv s dlitel'nym anesteziruiushchim deĭstviem (o neĭroliticheskom tipe mestnoobezbolivaiushchego deĭstviia).