title: The influence of long-term treatment with timolol on human tear lysozyme albumin content.
abstract: The long-term effect of timolol maleate on lacrimal secretion was tested by investigating the concentration of lysozyme and albumin in tears before the start of treatment and after different follow-up periods. A total of 25 patients (45 eyes) were treated with 0.25% or 0.5% timolol as the only antiglaucomatous therapy over a 7.6 month mean observation period (2-13 months). No significant change was found either in the lysozyme or in the albumin concentration.
mesh_terms: D000328:Adult; D000368:Aged; D000418:Albumins / Q000032:analysis; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000032:analysis; D011412:Propanolamines / Q000494:pharmacology*; D013666:Tears / Q000032:analysis / Q000187:drug effects* / Q000201:enzymology; D013999:Timolol / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000418:Albumins; D011412:Propanolamines; D013999:Timolol; D009113:Muramidase