Typhoid hepatitis with immunoglobulins and complement deposits in bile canaliculi.
Documented typhoid fever in a 26-year-old patient was complicated by acute hepatitis with unusually profound jaundice. Liver biopsy revealed focal cell necrosis, mononuclear cell infiltration. Kupffer cell proliferation, and mild cholestasis. Immunofluorescent studies of the liver biopsy revealed deposits of IgG, IgA, IgM, and C3 in the bile canaliculi, suggesting a role for damage by immune complexes in typhoid hepatitis.
D000328:Adult; D001648:Bile Canaliculi / Q000276:immunology*; D001653:Bile Ducts, Intrahepatic / Q000276:immunology*; D003165:Complement System Proteins / Q000032:analysis*; D006505:Hepatitis / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D008099:Liver / Q000473:pathology; D008297:Male; D014435:Typhoid Fever / Q000150:complications / Q000276:immunology* / Q000473:pathology
D007136:Immunoglobulins; D003165:Complement System Proteins