Inhibition of autologous rosette formation by monoclonal antibody to the sheep erythrocyte receptor.
The commercial monoclonal HuLyT-3, and which recognizes a 55,000-dalton polypeptide associated with the receptor for SRBC on human T lymphocytes, was capable of blocking rosette formation between human T cells and autologous human RBC. Lysostripping of the T cell surface with HuLyT-3 abolished rosette formation with both sheep and autologous RBC. The data suggest that a common structure is involved in the spontaneous rosetting of both sheep and human RBC by human T cells.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000950:Antigens, Ly / Q000276:immunology; D001667:Binding, Competitive; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D009439:Neuraminidase / Q000494:pharmacology; D011948:Receptors, Antigen, T-Cell; D011971:Receptors, Immunologic / Q000187:drug effects; D012397:Rosette Formation; D012756:Sheep
D000911:Antibodies, Monoclonal; D000950:Antigens, Ly; D011948:Receptors, Antigen, T-Cell; D011971:Receptors, Immunologic; D009439:Neuraminidase