Animal model of intracutaneous melanoma.
An animal model which allows for the implantation and development of intracutaneous melanoma is described. Intradermal vesicles are created by a negative pressure apparatus in DBA/2J mice. S91 melanoma cells are injected into the blister cavities. Tumor growth occurs within 7 days and the yield approaches 100%. This model is a rapid, efficient, and applicable system for the study of melanoma growth dynamics and of the effects of systemic and topical anti-tumor agents on melanoma proliferation.
D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D008545:Melanoma / Q000473:pathology*; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*; D013997:Time Factors