[Characteristics of metabolism in fast-labelling nuclear RNA spleen cells of mice with Rauscher leukemia].
A component of quickly labelling D-RNA with a sedimentation coefficient of 35 S is revealed in spleen cell nuclei of mice infected with the leukemogenic Rauscher virus. The component is absent in healthy animals. It is labelled for 5 min of incubation with the label and under conditions of chase experiment disappears from the nucleus 2 h later differing from the rest of leukemic cell D-RNA in a higher metabolic activity. [3H] RNA with a sedimentation coefficient of 35 S is detected in cytoplasm of RNA synthetizing in leukemic cells under the effect of leukemogenic virus. It is the RNA of messenger type though it seems possible that a part of it remains in the nucleus and performs intranuclear functions.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D007700:Kinetics; D007942:Leukemia, Experimental / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D008970:Molecular Weight; D012333:RNA, Messenger / Q000302:isolation & purification / Q000378:metabolism; D012334:RNA, Neoplasm / Q000302:isolation & purification / Q000378:metabolism*; D011925:Rauscher Virus / Q000235:genetics; D013154:Spleen / Q000378:metabolism*; D013997:Time Factors
D012333:RNA, Messenger; D012334:RNA, Neoplasm
Osobennosti metabolizma bystrometiashchikhsia iadernykh RNK kletok selezenki mysheĭ pri leĭkoze Raushera.