The use of buccal partitioning as a model to examine the effects of aluminium hydroxide gel on the absorption of propranolol.
1 A buccal partitioning model showed no absorption interaction between propranolol and aluminium hydroxide gel in three volunteer subjects. 2 The previously reported in vivo interaction is therefore not due to propranolol adsorption to, or complexation with the antacid but is more probably due to a decreased gastric emptying rate caused by the antacid. 2 Buccal partitioning has proved useful in the examination of the mechanism of the propranolol/aluminium hydroxide absorption interaction and may also be a suitable in vivo bioavailability screening model for other drugs which can be partitioned in the buccal membranes.
D000042:Absorption; D000536:Aluminum Hydroxide / Q000008:administration & dosage / Q000494:pharmacology*; D002610:Cheek; D004347:Drug Interactions; D005782:Gels; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008954:Models, Biological; D009061:Mouth Mucosa / Q000378:metabolism*; D011433:Propranolol / Q000378:metabolism*
D005782:Gels; D000536:Aluminum Hydroxide; D011433:Propranolol