Decreased insulin receptors but normal glucose metabolism in Duchenne muscular dystrophy.
Compared to matched controls, 17 patients with Duchenne muscular dystrophy showed decreased insulin binding to monocytes due to decreased receptor concentration. These patients showed no signs of altered glucose metabolism and retrospective analysis of the clinical records of a further 56 such patients revealed no modification in carbohydrate metabolism. These data suggest that reduced insulin receptor number does not produce overt modifications of glucose metabolism in Duchenne muscular dystrophy.
D000293:Adolescent; D000328:Adult; D002462:Cell Membrane / Q000378:metabolism; D002648:Child; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D009000:Monocytes / Q000378:metabolism; D009136:Muscular Dystrophies / Q000378:metabolism*; D011972:Receptor, Insulin / Q000378:metabolism*
D011972:Receptor, Insulin; D005947:Glucose