D-Penicillamine-induced severe pneumonitis.
We report the first histologically described case of severe D-penicillamine-induced pneumonitis. It occurred in a 73-year-old woman who suffered from rheumatoid arthritis and had previously demonstrated gold intolerance. Pathologic study disclosed marked interstitial and alveolar damage resembling that described with certain chemotherapeutic agents. We assess the drug's responsibility, discuss possible pathogenetic pathways, and provide suggestions regarding the patient on a D-penicillamine schedule.
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D005260:Female; D006046:Gold / Q000009:adverse effects; D006801:Humans; D010396:Penicillamine / Q000009:adverse effects*; D011014:Pneumonia / Q000139:chemically induced* / Q000473:pathology; D011650:Pulmonary Alveoli / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000139:chemically induced
D006046:Gold; D010396:Penicillamine