Genetic control of eosinophilia in mice: gene(s) expressed in bone marrow-derived cells control high responsiveness.
A heterogeneity in the capacity of strains of mice to mount eosinophilia is described. BALB/c and C3H are eosinophil high responder strains (EO-HR) and CBA and A/J are eosinophil low responder strains (EO-LR), judged by the response of blood eosinophils to Ascaris suum, and the response of blood, bone marrow, and spleen eosinophils to keyhole limpet hemocyanin given 2 days after 150 mg/kg cyclophosphamide. Some of the gene(s) for high responsiveness appear to be dominant because (EO-HR X EO-LR)F1 mice were intermediate to high responders. This gene is expressed in bone marrow-derived cells because radiation chimeras of the type EO-HR leads to F1 were high responders and EO-LR leads to F1 were low responders. This description of a genetic control of eosinophilia in mice may be useful in understanding the role of this cell in parasite immunity and allergy.
D000818:Animals; D001200:Ascaris / Q000276:immunology; D001854:Bone Marrow Cells; D003433:Crosses, Genetic; D003520:Cyclophosphamide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004802:Eosinophilia / Q000139:chemically induced / Q000235:genetics* / Q000276:immunology; D005260:Female; D005620:Freund's Adjuvant / Q000494:pharmacology; D005799:Genes, Dominant; D006433:Hemocyanins / Q000494:pharmacology; D006968:Hypersensitivity, Delayed / Q000139:chemically induced; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D011828:Radiation Chimera
D003520:Cyclophosphamide; D005620:Freund's Adjuvant; D006433:Hemocyanins