Effect of albumin microinfusion on proximal tubular pressure.
The present study tested the idea that protein in tubular fluid is responsible for an increase in resistance of Henle's loops in the nephrotic syndrome. Single proximal tubules of anesthetized, normal rats were microinfused with an isotonic equilibrium solution containing 0--250 mg/100 ml bovine serum albumin while proximal tubular pressure (PTP) was continuously recorded. Microinfusion at 16 and 40 nl/min produced significant (p less than 0.01) increments in PTP. There was no significant effect (p greater than 0.50) of albumin. These results suggest that moderate concentrations of albumin in tubular fluid do not cause an increase in resistance to tubular fluid flow.
D000818:Animals; D007684:Kidney Tubules / Q000187:drug effects*; D008297:Male; D011312:Pressure; D051381:Rats; D011919:Rats, Inbred Strains; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000494:pharmacology*
D012710:Serum Albumin, Bovine