[Lung tissue diffusion of intravenous trimethoprim-sulfamethoxazole combination (author's transl)].
In 13 cases of pneumonectomy, we have studied the concentration of TMP-SMZ in tissue and serum, after three days of treatment. Four hours after TMP-SMZ injection, the tissue's samples obtained from crushed and mixed ; the dosages were performed by a microbiological assay. As we previously described in bronchial secretions : the lung penetration of TMP is important ; the tissue concentrations were higher than in serum ; the diffusion of SMZ is low. The ratio of TMP to SMZ were diffusion of SMZ is low. The ratio of TMP to SMZ were different in serum and tissue, but the antibacterial activity is not affected in vitro by the value's modification.
D000328:Adult; D000368:Aged; D001419:Bacteria / Q000187:drug effects; D004338:Drug Combinations / Q000097:blood / Q000378:metabolism; D004357:Drug Synergism; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008875:Middle Aged; D011013:Pneumonectomy; D013420:Sulfamethoxazole / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D014295:Trimethoprim / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole
Diffusion pulmonaire de l'association triméthoprime-sulfaméthoxazole (TMP-SMZ).