Suppression of water intake by immune complex formation in the hypothalamus. Implications for systemic lupus erythematosus.
Immune complex formation in the perifornical region of the hypothalamus resulted in depressed water consumption in rats, but did not consistently alter body temperature. The antibody with an unrelated antigen did not affect water consumption or body temperature. These results support the notion that immune complex reactions within the central nervous system can alter behavior.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000502:physiology*; D001831:Body Temperature; D004195:Disease Models, Animal; D004326:Drinking; D007031:Hypothalamus / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology; D007263:Infusions, Parenteral; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000936:Antigen-Antibody Complex