Reversal of digitalis-induced mesenteric vasospasm by sodium nitroprusside.
Digitalis constricts the peripheral vasculature. When digitalis is administered to patients whose mesenteric blood flow is reduced secondary to heart failure, the vasoconstrictor action coupled to reduced mesenteric flow may result in mesenteric ischemia or hemorrhagic bowel necrosis. The clinical syndrome of mesenteric ischemia secondary to heart failure and excess digitalis developed in a patient. Splanchnic vasoconstriction was proved angiographically. Both the vasospasm and clinical evidence of mesenteric ischemia were promptly reversed by sodium nitroprusside.
D000328:Adult; D003251:Constriction, Pathologic / Q000139:chemically induced / Q000188:drug therapy; D004074:Digitoxin / Q000009:adverse effects*; D005292:Ferricyanides / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008638:Mesenteric Arteries / Q000000981:diagnostic imaging / Q000187:drug effects*; D009599:Nitroprusside / Q000627:therapeutic use*; D011859:Radiography; D014652:Vascular Diseases / Q000139:chemically induced / Q000188:drug therapy
D005292:Ferricyanides; D009599:Nitroprusside; D004074:Digitoxin