Development of bile acid biogenesis in the rat: effect of neonatal thyroidectomy, adrenalectomy, and streptozotocin-induced diabetes.
Effect of neonatal thyroidectomy, adrenalectomy and streptozotocin-induced diabetes in rats on the bile acid pool size and composition at weaning was examined. Adrenalectomy caused a significant (p less than 0.05) decrease in the total bile acid pool with significant reductions (p less than 0.05) in both cholic and chenodeoxycholic acids. Thyroidectomy on the other hand caused a specific decrease (p less than 0.05) in chenodeoxycholic acid pool. Streptozotocin-induced diabetes caused (a) a decrease (p less than 0.05) in total bile acid pool with a significant (p less than 0.05) reduction in chenodeoxycholic acid, and (b) an increase in plasma cholesterol levels.
D000315:Adrenalectomy; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D001647:Bile Acids and Salts / Q000378:metabolism*; D002635:Chenodeoxycholic Acid / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D002793:Cholic Acids / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013965:Thyroidectomy; D014886:Weaning
D001647:Bile Acids and Salts; D002793:Cholic Acids; D002635:Chenodeoxycholic Acid; D002784:Cholesterol