title: Exercise assessment of sinoatrial node function following the Mustard operation.
abstract: To screen for sinoatrial node dysfunction following the Mustard procedure for transposition of the great arteries, we studied the chronotropic response to graded maximal treadmill exercise in 29 patients at mean 6.7 years after operation. Although 93% of patients had normal resting heart rate (HR), 83% demonstrated significant depression of maximum HR and/or recovery HR after termination of exercise. These findings were similarly present among a subset of 13 patients with normal exercise tolerance. Resting and exercise-induced HR in 10 patients receiving chronic digoxin therapy were no different than in the 19 patients without medication. Sixteen patients with abnormal chronotropic responses to exercise had intracardiac electrophysiologic evaluation which confirmed sinoatrial node dysfunction in nine. Abnormal HR responses did not correlate with clinical symptoms, cardiac arrhythmias, or postoperative hemodynamics. Maximal exercise testing may be a sensitive noninvasive method to identify sinoatrial node dysfunction in postoperative children.
mesh_terms: D000293:Adolescent; D000328:Adult; D001282:Atrial Flutter / Q000175:diagnosis; D006328:Cardiac Catheterization; D002648:Child; D002675:Child, Preschool; D004077:Digoxin / Q000627:therapeutic use; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006327:Heart Block / Q000175:diagnosis; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D012849:Sinoatrial Node / Q000502:physiology / Q000503:physiopathology*; D014188:Transposition of Great Vessels / Q000601:surgery*
chemical_list: D004077:Digoxin