Differential effects of diazepam (valium) on brain stimulation reward sites.
The effect of diazepam on electrical self-stimulation of the dorsolateral hippocampus was tested in 19 male rats. Two mg/kg of diazepam significantly suppressed lever pressing rates at both high and low current intensities, whereas 1 mg/kg did so only at the low current intensity. The lowest dose (0.5 mg/kg) of diazepam had no significant effect. The second experiment tested the generality of the effect of diazepam on self-stimulation using electrodes in the lateral hypothalamus. A significant increase in lever pressing rates was observed at all dose levels.
D000818:Animals; D003975:Diazepam / Q000494:pharmacology*; D004558:Electric Stimulation; D004569:Electroencephalography; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D012201:Reward; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology; D012653:Self Stimulation / Q000187:drug effects*
D003975:Diazepam