title: [Diagnosis and treatment of disorders in pancreatic enzyme secretion, liver function and gastric motor activity in diabetes mellitus].
abstract: Examination of 106 patients with medium severe and severe forms of diabetes mellitus with a history of the disease of more than 3 years revealed a consistent reduction in the liver blood flow rate, in hepatocyte absorption and metabolic functions, pancreatic enzyme secretion, and gastric contractility. The bromsulphthalein, ujoviridin, and pancreozymin tests, as well as synthetic peptide benzoyl-tyrosyl-para-aminobenzoic acid tolerance test, electromanometric measurements of the cardial and pyloric sphincters tones, intracavitary pressure in the stomach and the rate of the test solution evacuation by the stomach are reliable and sensitive indices of the disturbances in the liver, exocrine portion of the pancreas, and gastric contractility in diabetes patients. Pancreozymin showed hepatotrophic properties, and metoclopramid (cerucal, reglan) increased gastric motility reduced in diabetes.
mesh_terms: D000328:Adult; D002766:Cholecystokinin / Q000627:therapeutic use; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000503:physiopathology; D005769:Gastrointestinal Motility; D006801:Humans; D008099:Liver / Q000503:physiopathology*; D008107:Liver Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D008787:Metoclopramide / Q000627:therapeutic use; D008875:Middle Aged; D010179:Pancreas / Q000201:enzymology* / Q000378:metabolism; D010182:Pancreatic Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D013272:Stomach Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D002766:Cholecystokinin; D008787:Metoclopramide
vernacular_title: Diagnostika i lechenie narusheniĭ pankreaticheskogo fermentovydeleniia, funktsii pecheni i motornoĭ aktivnosti zheludka pri sakharnom diabete.