title: Tissue response to dense apatite implants in rats.
abstract: Dense (97-99.9%) hydroxylapatite ceramics were implanted in muscle and bone tissue of rats. The aim of this study was to compare apatite implant material made of commercially available powder with laboratory powder prepared in a painstaking manner. Biocompatibility, biostability, and adherence to bone were evaluated. In muscle tissue the implants were found to be encapsulated with a very thin connective tissue layer. Implantation in excavated bone tissue resulted with new bone directly deposited against the implant surface, irrespective of the type of hydroxylapatite used. When the implants were protruding from the bone surface, bone appeared to grow up to the edge of the protruding part of the implant. A very strong bonding developed; push-out tests indicated that the bone fractured but never at the interface. Histologic studies proved that a sleeve of newly formed bone closely encased the implant, regardless of shape. It was concluded that dense apatite ceramics are fully compatible with the tibia of the rat and that no degradation of the implant material occurred for intervals of up to 6 months after implantation. The very strong bonding without mechanical retention indicated continuity between artificial hydroxylapatite and natural bone. No difference was found between the biological behavior of the hydroxylapatites prepared from commercial or laboratory starting powders.
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001846:Bone Development; D006882:Hydroxyapatites; D008854:Microscopy, Electron; D019736:Prostheses and Implants; D051381:Rats; D013977:Tibia / Q000473:pathology / Q000601:surgery
chemical_list: D001672:Biocompatible Materials; D006882:Hydroxyapatites