[Sulfonamides with central nervous system action. V].
A series of 2-nitro and 2-aminobenzenesulfon-N-acylamides variously substituted on the benzene ring were prepared and tested for anticonvulsant activity (electro shock, pentamethylenetetrazole). Some of the compounds tested gave some measure of protection against convulsions induced by electric shock. The importance of the trifluoromethyl substituent in this effect was demonstrated.
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D004597:Electroshock; D005260:Female; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology
D000927:Anticonvulsants; D013449:Sulfonamides; D010433:Pentylenetetrazole
Solfonamidi ad azione sul sistema nervoso centrale. Nota V.