Effects of L-aspartic acid, L-asparagine and/or L-asparaginase on forced swimming-induced immobility, analgesia, and decrease in rectal temperature in rats.
The effect of L-aspartic acid, L-asparagine and/or L-asparaginase were compared with those of imipramine on immobility, number of defecations, increase of nociceptive threshold, and hypothermia, induced by forced swimming in rats. L-Aspartic acid was found to be as effective as imipramine in reducing the effects of forced swimming, presumable by normalizing the decreased level of endogenous L-aspartic acid, due to the inhibition of L-asparaginase activity and/or by stimulating the inhibited enzyme. The other treatments antagonized the immobility, but not the increased number of defecations. All compounds abolished the elevation of nociceptive threshold and hypothermia.
D000698:Analgesia; D000818:Animals; D001215:Asparaginase / Q000494:pharmacology*; D001216:Asparagine / Q000494:pharmacology*; D001224:Aspartic Acid / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects*; D003672:Defecation / Q000187:drug effects; D007099:Imipramine / Q000494:pharmacology; D009068:Movement / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013550:Swimming
D001224:Aspartic Acid; D001216:Asparagine; D001215:Asparaginase; D007099:Imipramine