Effects of 2-deoxy-D-glucose on plasma and adrenal concentrations of corticosterone and aldosterone in standard diet fed and potassium loaded rats.
The concentrations of corticosterone, aldosterone and electrolytes (Na+ and K+) were measured in the plasma and adrenal glands, following 2-deoxy-D-glucose (2-DG) treatment (2 injections of 50 mg/ml/100 g body weight) in standard diet fed and potassium loaded rats. In both regimens, 2-DG increased the concentrations of corticosterone mainly in the plasma (+144.8% and 229.5%) and to a lesser extent, in the adrenal glands (+50.9% and 62.5%). Conversely, 2-DG treatment was followed by a steep decline in plasma concentrations of aldosterone both in standard diet fed rats (-65.2%) and in potassium loaded rats (-83.9%), in spite of a marked increase in plasma (+233.3%) and in adrenal (+54.9%) levels of aldosterone after potassium loading; adrenal aldosterone content was essentially the same. Plasma and adrenal electrolytes concentrations and hematocrit varied very little after 2-DG treatment.
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000450:Aldosterone / Q000097:blood / Q000378:metabolism*; D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000378:metabolism*; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D004032:Diet; D008297:Male; D011188:Potassium / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains
D003837:Deoxy Sugars; D000450:Aldosterone; D003847:Deoxyglucose; D011188:Potassium; D003345:Corticosterone