Protective value of diphenylhydantoin and vitamin A against stress ulcer.
The protective effect of vitamin A and diphenylhydantoin on restraint ulcers has been studied in 105 rats. The Sprague-Dawley female rats were divided into four groups. All were fasted for 24 hours, then restrained and fasted for another 24 hours. Control rats (receiving 1 ml of 0.9% saline solution) were compared with groups receiving either vitamin A, diphenylhydantoin, or both. Diphenylhydantoin significantly (P less than 0.001) protected the rats against ulcers. Vitamin A showed no protective effect and did not potentiate the effect of diphenylhydantoin.
D000818:Animals; D005260:Female; D010437:Peptic Ulcer / Q000517:prevention & control*; D010672:Phenytoin / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological; D014801:Vitamin A / Q000627:therapeutic use*
D014801:Vitamin A; D010672:Phenytoin