[Fetal death and benign hemolytic disease of the newborn from anti-Cellano alloimmunization: 2 new case reports].
The first case is provided by a french women (KK, husband k/k) who delivered a first healthy full term infant in 1970 and received one blood unit at this time. In 1972 and 1975, his second and fourth pregnancies ended by spontaneous abortion. In 1974 and 1976, she delivered stillborn infants with hydrops fetalis during the sixth month. In serum, anti-k antibody reacted by the indirect antiglobulin test with a titer of 4 096. In the second case, french women delivered a first full term female infant who had a strongly positive direct antiglobulin test. The mother had received one blood unit ten years before during nephrectomy. Her red blood cell were KK and her husband was kk. She had a anti-Cellano in serum reactive in the indirect antiglobulin test with a titer of 16. The infant developed a mild hyperbilirubinemia and recovered without treatment these two cases confirm the variable effect of maternal anti-k antibody evidenced by few other published cases.
D000027:Abortion, Incomplete / Q000209:etiology / Q000276:immunology; D000328:Adult; D001789:Blood Group Antigens / Q000276:immunology*; D004899:Erythroblastosis, Fetal / Q000209:etiology* / Q000276:immunology; D005260:Female; D005313:Fetal Death / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007114:Immunization; D007231:Infant, Newborn; D007518:Isoantibodies / Q000096:biosynthesis*; D007626:Kell Blood-Group System / Q000276:immunology*; D008431:Maternal-Fetal Exchange; D010375:Pedigree; D011247:Pregnancy
D001789:Blood Group Antigens; D007518:Isoantibodies; D007626:Kell Blood-Group System
Mort foetale et maladie hémolytique bénigne du nouveau-né par allo-immunisation anti-Cellano: Deux nouvelles observations.