title: A critique of the use of DNA synthesis as a measure of the effect of mitogens on lymphocytes.
abstract: The use of DNA synthesis as a measure of mitogenic activity in lymphocytes is reanalyzed in the light of the Continuum Model, and it is suggested that although lymphocytes may have a linear response with regard to mitogen concentration, the curves using thymidine may show a threshold response at low concentrations and a decrease in activity at high concentrations.
mesh_terms: D002455:Cell Division; D004247:DNA / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007700:Kinetics; D008214:Lymphocytes / Q000378:metabolism*; D008934:Mitogens / Q000494:pharmacology*; D008954:Models, Biological; D013936:Thymidine / Q000378:metabolism
chemical_list: D008934:Mitogens; D004247:DNA; D013936:Thymidine