[Isoenzymatic spectra of lactate dehydrogenase in various areas of the rat brain and the influence of thyroidin on them].
The paper deals with distribution pattern of lactate dehydrogenase (LDH) isoenzymes in certain regions of the adult rat brain and its changes caused by thyroidin administration. The presence of five LDH-isoenzymes is established in the brain regions under study. The cerebellum and stem were marked by a higher LDH1-isoenzyme activity than in the cortex and hypothalamus. Experimental hyperthyroidism caused a decrease in the total LDH-activity in the cortex, cerebellum and stem, and a pronounced redistribution in the LDH-isoenzymes ratio. The latter was manifested by an increase in the LDH-isoenzyme relative activity adopted to aerobic metabolism. The degree of this shift depends on the duration of the hormone administration and dose.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D006728:Hormones / Q000494:pharmacology*; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D051381:Rats; D013963:Thyroid Hormones / Q000494:pharmacology*; D014018:Tissue Distribution
D006728:Hormones; D007527:Isoenzymes; D013963:Thyroid Hormones; C004227:thyroidin; D007770:L-Lactate Dehydrogenase
Izofermentnye spektry laktatdegidrogenazy v nekotorykh otdelakh golovnogo mozga krys i vliianie na nikh tireoidina.