Disseminated cryptococcus in an infant with severe combined immunodeficiency.
Opportunistic infections, often fatal, are frequent concomitants of congenital and acquired immunodeficiencies. The authors report a case of fatal cryptococcosis in a 5-month-old male infant with severe combined immunodeficiency. The anatomic distribution of cryptococcal lesions suggests that the terminal small intestine, as well as the lower respiratory tract, may serve as a portal of entry for this organism.
D003453:Cryptococcosis / Q000209:etiology* / Q000401:mortality; D006801:Humans; D007082:Ileum / Q000473:pathology; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000473:pathology; D007223:Infant; D008168:Lung / Q000473:pathology; D008198:Lymph Nodes / Q000002:abnormalities; D008214:Lymphocytes; D008297:Male; D010950:Plasma Cells; D013154:Spleen / Q000473:pathology; D013950:Thymus Gland / Q000002:abnormalities