Effect of diazepam pretreatment on succinylcholine-induced muscle fasciculation in the dog.
The efficacy of diazepam in attenuation of succinylcholine-induced muscle fasciculations was studied in the dog. Dosage levels of 0.11, 0.22, 0.55, or 1.1 mg of diazepam/kg of body weight were studied in 4 groups of 5 dogs each; another group of 5 dogs served as a control. There was no difference in the occurrence or severity of succinylcholine-induced muscle fasciculations between dogs given diazepam and nontreated controls. Using serum potassium as a quantitative index of physiologic effects of muscle depolarization, differences could not be detected between treated and nontreated dogs.
D000818:Animals; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004283:Dog Diseases / Q000139:chemically induced / Q000188:drug therapy*; D004285:Dogs; D005207:Fasciculation / Q000139:chemically induced / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D008297:Male; D009461:Neurologic Manifestations / Q000662:veterinary*; D011188:Potassium / Q000097:blood; D011292:Premedication; D013390:Succinylcholine / Q000009:adverse effects
D013390:Succinylcholine; D003975:Diazepam; D011188:Potassium