[Immunothrombocytopenia of the newborn caused by platelet-specific antibodies (anti-P1A1) (author's transl)].
For the first time in the German speaking area 8 cases of neonatal immunothrombocytopenia caused by platelet-specific P1A1 antibodies could be ascertained. The disease is caused by fetomaternal incompatibility against platelet antigens. All mothers were healthy. The children showed a postnatal tendency for petechial haemorrhages. Cerebral haemorrhages occurred in two cases. Optimal treatment consists of administration of P1A1-negative platelets (perhaps of the mother). Demonstration of platelet antibodies is possible nowadays by adequate serological methods.
D000328:Adult; D000906:Antibodies / Q000032:analysis; D001792:Blood Platelets / Q000276:immunology; D002543:Cerebral Hemorrhage / Q000209:etiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology* / Q000276:immunology; D008297:Male; D011247:Pregnancy; D013921:Thrombocytopenia / Q000150:complications / Q000209:etiology* / Q000276:immunology
D000906:Antibodies
Allimmunthrombozytopenipe der Neugeborenen durch thrombozytenspezifische Antikörper (Anti-P1A1).