title: [Model of two-headed myosin cross-bridge and possibility of its motion in skeletal muscles].
abstract: The model of "two-headed" myosin cross-bridge is proposed whose motion is realized by stepping of its two heads on two actin filaments. By Offer and Elliott graphical method possible attachment sites on the actin filaments are determined for skeletal muscles and the geometrical possibility of "two-headed" cross-bridge stepping during muscle contraction is shown. It can be assumed that the recently discovered in Characean cells motion of oligomeric myosin along actin filaments can proceed by a similar mechanism.
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D046911:Macromolecular Substances; D008958:Models, Molecular; D009119:Muscle Contraction; D009132:Muscles / Q000378:metabolism*; D009218:Myosins / Q000378:metabolism*; D011487:Protein Conformation
chemical_list: D000199:Actins; D046911:Macromolecular Substances; D009218:Myosins
vernacular_title: Model' "dvukhgolovogo" miozinovogo mostika i vozmozhnost' ego dvizheniia v skeletnykh myshtsakh.