Subclinical effects of chronic increased lead absorption--a prospective study. Part IV. Evaluation of heme synthesis effects.
The effects of lead exposure on heme synthesis in workers with subclinical responses and in controls were evaluated. delta-Aminolevulinic acid dehydratase (ALA-d) correlated significantly with blood lead levels in the control group but not with those in the exposed group. Free erythrocyte protoporphyrin correlated significantly with blood lead levels in the exposed group but not with those in the controls and was found to be a good indicator of blood lead history among exposed persons. Hemoglobin values determined at initial employment were not statistically different from those determined during the baseline test for a group of 12 workers with a maximum blood lead level of 86 micrograms/100 ml during their exposure history. The effect such heme inhibition may have on other body functions is uncertain.
D004781:Environmental Exposure; D006400:Hematocrit; D006418:Heme / Q000096:biosynthesis*; D006801:Humans; D007854:Lead / Q000097:blood / Q000494:pharmacology*; D000623:Porphobilinogen Synthase / Q000097:blood; D011446:Prospective Studies; D011524:Protoporphyrins / Q000097:blood
D011524:Protoporphyrins; D007854:Lead; D006418:Heme; D000623:Porphobilinogen Synthase