[Electron microscopic, histochemical and functional assessment of the effect of aspirin on the thrombocytes of healthy persons and ischemic heart disease patients].
Electron microscopical and electron histochemical studies and functional investigation of platelets have been undertaken in 10 normal individuals and 20 patients with ischaemic heart disease and angina pectoris of effort before and after acetylsalicylic acid (ASA) administration during 3 days. In ischaemic heart disease changes in the ultrastructure of platelets have been recorded, pointing to their activation. After ASA administration there was decrease of functional activity, due to structural changes in the plasma membrane, lysosome membranes, fragmentation of platelets, enhanced process of autophagia, decrease of enzymatic activity of structure organelles of platelets.
D000328:Adult; D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy; D001241:Aspirin / Q000009:adverse effects*; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy*; D006651:Histocytochemistry; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D010979:Platelet Function Tests
D001241:Aspirin
Elektronno-gistokhimicheskaia i funktsional'naia otsenka vliianiia aspirina na trombotsity zdorovykh lits i bol'nykh ishemicheskoĭ bolezn'iu serdtsa.