Stimulation of H+ ion secretion from the isolated mouse stomach by sodium fluoride.
The effect of sodium fluoride on H+ ion secretion was investigated in the isolated distended mouse stomach. It was found that sodium fluoride on its own caused dose-related stimulation of H+ ion secretion. Sodium fluoride did not inhibit H+ ion secretion induced by histamine. The possible mechanisms involved are discussed. It is considered that sodium fluoride might stimulate H+ ion secretion by causing histamine release and by increasing cyclic AMP formation in the intact gastric mucosa.
D000818:Animals; D005260:Female; D005459:Fluorides / Q000494:pharmacology*; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D051379:Mice; D012969:Sodium Fluoride / Q000494:pharmacology*
D006632:Histamine; D012969:Sodium Fluoride; D005459:Fluorides