[Use of radionuclides to study structural differences in mitochondrial and lysosomal membranes of normal and neoplastic cells].
Radionuclids 111In, 67Ga and Na275 SeO3 were seen accumulated in subcellular structures of transplanted and carcinogen-induced tumors of mice and rats. Lysosomes and mitochondria of tumor cells were labeled much less compared to the normal tissue. Maximal radioactivity was found in mitochondrial or lysosomal membranes, both in normal and tumor cells. It is suggested that radionuclids may be useful in study of conformational changes in normal membrane systems in the course of malignisation.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000648:ultrastructure*; D004052:Diethylnitrosamine; D005710:Gallium Radioisotopes; D007204:Indium; D007425:Intracellular Membranes / Q000648:ultrastructure; D008113:Liver Neoplasms / Q000139:chemically induced / Q000648:ultrastructure*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000648:ultrastructure*; D008247:Lysosomes / Q000648:ultrastructure*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008928:Mitochondria / Q000648:ultrastructure*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000648:ultrastructure; D011868:Radioisotopes; D051381:Rats; D012643:Selenium
D005710:Gallium Radioisotopes; D011868:Radioisotopes; D007204:Indium; D004052:Diethylnitrosamine; D012643:Selenium
Primenenie nekotorykh radionuklidov dlia izucheniia strukturnykh razlichiĭ membran mitokhondriĭ i lizosom normal'nykh i opukholevykh kletok.