title: Penicillin is an active-site inhibitor for four genera of bacteria.
abstract: The hypothesis that penicillin acts as an active-site inhibitor cell wall biosynthesis was tested by a method of partial proteolytic mapping of penicillin-binding sites versus substrate-binding sites in cell wall D-alanine carboxypeptidases. This enzyme was obtained from four genera of bacteria, purified, and tested.
mesh_terms: D001407:Bacillus / Q000201:enzymology; D001419:Bacteria / Q000201:enzymology*; D001665:Binding Sites; D002268:Carboxypeptidases / Q000378:metabolism*; D002267:Muramoylpentapeptide Carboxypeptidase / Q000378:metabolism*; D010400:Penicillin G / Q000378:metabolism* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000201:enzymology; D013302:Streptomyces / Q000201:enzymology
chemical_list: D002268:Carboxypeptidases; D002267:Muramoylpentapeptide Carboxypeptidase; D010400:Penicillin G