[Monoaminodicarboxylic acids and their amides in tissues during regressive tumor growth].
It is established that the content of monoaminodicarboxylic acids and their amides in the organism tissues decreases not so sharply in the course of regressive development of the viral Moloney sarcoma as in case of its progressive growth. The process of the sarcoma spontaneous resolution is accompanied by a considerable increase in the content of these substances. Being used in the process of Moloney sarcoma growth and resolution, asparaginase, reducing the content of the above-mentioned substances in tissues, intensified in tumour growth and inhibited the tumour resolution. The contrary effect on the tumour growth was obtained by an additional introduction of monoaminodicarboxylic acids and their amides from outside. A conclusion is drawn about the influence of these substances metabolism on the formation of antitumoural defence physiological mechanisms, contributing in this case to a spontaneous tumour resolution.
D000600:Amino Acids, Dicarboxylic / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D007942:Leukemia, Experimental / Q000503:physiopathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009365:Neoplasm Regression, Spontaneous
D000600:Amino Acids, Dicarboxylic
Monoaminodikarbonovye kisloty i ikh amidy v tkaniakh pri regressivnom kharaktere rosta opukholi.