[Effect of strophanthin and celanide on the tonus of the cerebral and peripheral vessels].
Resistography was used in acute experiments on anesthetized cats to demonstrate that cardiac glycosides, particularly celanide, often cause phasic (constrictive-dilative) responses of the perfused vessels and general arterial pressure. The constrictive response of the perfused vessels did not depend on the concentration of calcium ions in the blood and was not prevented by preliminary administration of dihydroergotoxin. However, glycosides prolonged the vasoconstrictive effect of noradrenaline. The vasodilative response to glycosides was reversed by atropine. It is assumed that the constrictive response is myotropic, whereas the dilative one is cholinergic in nature.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects*; D002301:Cardiac Glycosides / Q000494:pharmacology*; D002415:Cats; D002536:Cerebral Arteries / Q000187:drug effects*; D006614:Hindlimb / Q000098:blood supply; D007799:Lanatosides / Q000494:pharmacology*; D013328:Strophanthins / Q000494:pharmacology*; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects*
D002301:Cardiac Glycosides; D007799:Lanatosides; D013328:Strophanthins; C018548:lanatoside C
Vliianie strofantina i tselanida na tonus mozgovykh i perifericheskikh sosudov.