[Parathyroid function in Paget's disease of bone].
The serum level of parathormone (PTH) measured in 151 cases of untreated Paget's bone disease was found to have increased 23 times (15 p. cent). This increase in PTH is associated with a significant reduction in the calcemia and the calciuria noted in Paget's disease patients having a high PTH, but it was not linked to the spread or to the biological activity of the disease. Th involvement was clearly a case of secondary hyperparathyroidism (HPT), linked to the increased calcic requirements of pagetic bone. This might explain the great frequency of appearance of primitive HPT during the course of Paget's disease, and could be a factor in relative resistance to antiosteoclastic therapy calcitonin or diphosphonates.
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000097:blood / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D010280:Parathyroid Glands / Q000503:physiopathology*; D010281:Parathyroid Hormone / Q000097:blood
D010281:Parathyroid Hormone
La fonction parathyroïdienne dans la maladie osseuse de Paget.