[Effect of DNA on recovery of the hematopoiesis in mice with myelosan-induced hypoplasia].
CBA male mice received myelosan intraperitoneally in a dose of 10 mg/kg weekly for 5 weeks. One day after the second myelosan injection, the animals were given high-molecular DNA once a week for 9 weeks. DNA preparations were obtained from the milt of sturgeon fish. Heterologous DNA was shown to change the rate of hypoplasia development during myelosan administration and to affect the completeness of hemopoiesis recovery during discontinuation of cytostatic injections. This was determined by the action of the biopolymer on the colony-forming units and on differentiated myelokaryocytes. The action of DNA on hemopoiesis in mice with cytostatic hypoplasia affected the animals' survival. In the course of the observation period, the death in the group of untreated mice constituted 68%, while that in the group of treated animals to 20%.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000473:pathology; D002066:Busulfan / Q000009:adverse effects*; D003114:Colony-Forming Units Assay; D004247:DNA / Q000627:therapeutic use*; D004347:Drug Interactions; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA
D004247:DNA; D002066:Busulfan
Vliianie DNK na vosstanovlenie krovetsoreniia u mysheĭ s gipoplazieĭ vyzvannoĭ mielosanom.