Bitches, queens and prostaglandins.
Luteolysis can be obtained in bitches by prolonged administration of PGF2 alpha resulting in abortion in pregnant bitches. A prostaglandin analogue (TPT) can induce fetal resorption or abortion depending upon the time of administration. In an investigation comprising a few bitches, PGF2 alpha has given encouraging results for treatment of uterine disorders. In the queen prostaglandin can induce abortion and parturition, and it has, when administered during a long period, been used for treatment of pyometra. Irrespective of the preparation and dosage the administration of prostaglandin is accompanied by side effects lasting for up to 3 hours, and therefore further investigations are needed before prostaglandins can be recommended for use in bitches and queens.
D000028:Abortion, Induced; D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects; D004283:Dog Diseases / Q000188:drug therapy; D004285:Dogs / Q000097:blood; D005260:Female; D011247:Pregnancy; D011460:Prostaglandins F / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D011465:Prostaglandins, Synthetic / Q000494:pharmacology; D013492:Suppuration / Q000188:drug therapy
D011460:Prostaglandins F; D011465:Prostaglandins, Synthetic; C026677:9 alpha,11 alpha,15 alpha-trihydroxy-16-phenoxy-17,18,19,20-tetranorprosta-4,5,13-trienoic acid