title: Cerebral blood flow studies in man using recirculation corrected height/area (H/A) computations for intravenous injection of 133Xenon.
abstract: Our height/area (recirculation-corrected) non-invasive cerebral blood flow method compares well with k1 values and k average as determined from k1, k2, p1 and p2 by Obrist computations. The height/area method provides regional flow measurements with less variability than k1 due to low regional head counts, head motion and end-tidal gas sample variations. Derivation of the mathematical model is for a single flow compartment and suited for tomographic measurements such as PET. Collimated detector data using our computation provides a good approximation of flow even for multiple compartments. Our approach permits a lower counting rate by either a smaller isotope dose or better detector collimation than multicompartment curve fitting methods.
mesh_terms: D000328:Adult; D001827:Body Height; D001830:Body Surface Area; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000175:diagnosis; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D013990:Tidal Volume; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes