title: Loss in pattern-elicited electroretinograms in optic nerve dysfunction.
abstract: Both flash- and pattern-elicited electroretinograms and visual-evoked potentials were recorded from a patient with well-documented unilateral optic nerve dysfunction. Although the flash-elicited electroretinograms from the left and right eyes did not differ in amplitude or latency, the flash-elicited visual-evoked potentials were greatly attenuated. Prominent pattern-elicited electroretinograms and visual-evoked potentials, were recorded from the better eye, but neither could be obtained from the affected eye. These results supported the contention that pattern-elicited electroretinograms are derived from optic nerve activity and that the absence of such responses may be diagnostic of loss of optic nerve function. This suggests that testing protocols aimed at assessing optic nerve function might benefit from the inclusion of pattern-elicited electroretinographic recordings. We also obtained contrast sensitivity functions from both eyes. Although considerably suppressed, the contrast sensitivity of the affected eye exhibited a 3-octave range, indicating some pattern-processing capability.
mesh_terms: D000328:Adult; D004596:Electroretinography / Q000295:instrumentation / Q000379:methods*; D005074:Evoked Potentials, Visual; D005902:Glaucoma, Open-Angle / Q000150:complications; D006801:Humans; D008297:Male; D009901:Optic Nerve Diseases / Q000150:complications / Q000175:diagnosis*; D014787:Vision Tests; D014794:Visual Fields