title: Excretion of urinary volatile metabolites in response to alloxan induced diabetes of short duration in rats.
abstract: Alterations in urine volatile metabolites due to the induction of alloxan diabetes in the rat were examined by capillary gas chromatography and gas chromatography--mass spectrometry for the five days immediately following the onset of chronic hyperglycemia. Elevations of a number of metabolites were observed including several short chain ketones, acetophenone, 2-acetylfuran and indole. The value of urine volatile metabolic profiles as characteristic indicators of the diabetic condition is demonstrated through profiles obtained from a diabetic animal which spontaneously reverted to normal.
mesh_terms: D000818:Animals; D002849:Chromatography, Gas / Q000379:methods; D003921:Diabetes Mellitus, Experimental / Q000652:urine*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006943:Hyperglycemia / Q000652:urine; D007659:Ketones / Q000652:urine*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007659:Ketones