Human pattern-evoked retinal responses are altered by optic atrophy.
Electrical signals in response to both diffuse flashes of light and phase-alternating spatial patterns were recorded from the eyes and from the occipital scalp of a subject with a traumatic unilateral (right) optic nerve section. Clinical examination disclosed a grossly normal right eye with no light perception, a Marcus Gunn pupil, and an atrophic optic disc. The left eye was normal. The electroretinogram responses on the lesioned side (OD) were normal, but there was no pattern-evoked retinal response (PERR) and no recordable visual-evoked response present. The conclusion is that the optic nerve and ganglion cells appear to be selectively responsible for the PERR potential.
D000293:Adolescent; D004596:Electroretinography; D005074:Evoked Potentials, Visual; D006801:Humans; D008297:Male; D009896:Optic Atrophy / Q000209:etiology / Q000503:physiopathology*; D020221:Optic Nerve Injuries; D010775:Photic Stimulation / Q000379:methods*; D012160:Retina / Q000503:physiopathology