Short-term and long-term effects of chemoimmunotherapy on granulopoiesis: adjuvant therapy of breast cancer.
The effect of adjuvant chemoimmunotherapy on normal human granulopoiesis has been studied. The short-term pattern of hemopoietic depletion and regeneration confirms that human bone marrow shows reaction to cytotoxic agents similarly to that observed in animal experiments. A regenerative response to the drug-induced depletion of the committed stem cell compartment occurs very early, thus suggesting local CFUC population size control of negative feedback from the early granulocytic compartments. Levamisole in that particular regimen did not influence the reaction pattern of granulopoiesis following cytotoxic drug exposure. A model of quantitative evaluation leads to a description of compartment changes which is compatible with the concepts of hemopoietic reaction to cytotoxic drugs. Of particular importance to the planning of adjuvant therapy is the observation of a long-term defect of granulopoiesis after discontinuation of chemotherapy. Studies like those presented here should be performed on any regimen of adjuvant therapy to select the least toxic regimen when several cytotoxic combinations with similar activities are available.
D001853:Bone Marrow / Q000473:pathology; D001943:Breast Neoplasms / Q000276:immunology / Q000628:therapy*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy; D007978:Levamisole / Q000627:therapeutic use*; D008875:Middle Aged
D007978:Levamisole; D004317:Doxorubicin; D003520:Cyclophosphamide