BCG vaccine-induced lupus vulgaris.
A case of intradermal BCG vaccination was complicated by a lupus-like tuberculosis cutis progressive for over 30 years. The patient had been vaccinated twice with BCG in the affected site. A review of other BCG vaccine-induced cases of lupus vulgaris indicates that the incidence of this complication is markedly increased following multiple BCG vaccinations, but is rare following a single BCG vaccination. In our patient a skin biopsy specimen was characteristic for lupus vulgaris. Acid-fast stains from the tissue and cultures from the affected site were negative. The patient was successfully treated with rifampin.
D000328:Adult; D001500:BCG Vaccine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008177:Lupus Vulgaris / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D011241:Prednisone / Q000008:administration & dosage; D012293:Rifampin / Q000008:administration & dosage
D001500:BCG Vaccine; D011241:Prednisone; D012293:Rifampin