Copper metabolism in rats given di- or trithiomolybdates.
As one of a series of studies on the influence of S substitution of MoO4(2-) on the action of Mo as an antagonist of Cu, the effects of MoO2S2(2-) and MoOS3(2-) on the metabolism of Cu by rats have been investigated. Administration of either oxythiomolybdate increased both plasma Cu concentration and the retention of Cu by the albumin fraction of plasma. In contrast to the effects of MoS4(2-), described previously, neither oxythiomolybdate inhibited 64Cu absorption from the digestive tract or induced biochemical or clinical signs of Cu deficiency. Evidence is discussed suggesting that the potency of the thio- and oxythiomolybdates as inhibitors of Cu utilization is directly proportional to the degree of thio substitution within the series series MoO4- chi S chi 2-.
D000818:Animals; D002570:Ceruloplasmin / Q000378:metabolism; D003300:Copper / Q000097:blood / Q000378:metabolism*; D004032:Diet; D007408:Intestinal Absorption / Q000187:drug effects; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D008297:Male; D008982:Molybdenum / Q000097:blood / Q000494:pharmacology*; D051381:Rats; D014018:Tissue Distribution
C034539:dithiomolybdic acid; C034540:trithiomolybdic acid; D003300:Copper; D008982:Molybdenum; D002570:Ceruloplasmin