[Effectiveness of the combined use of tobramycin with carbenicillin or cephalosporins in experimental infection in mice caused by Providencia stuartii].
Antibacterial activity of tobramycin in combination with carbenicillin or cephalosporins against 20 strains of Providencia stuartii was studied. The combinations of tobramycin with carbenicillin (1 : 2.5) or cephaloridine (1 : 1) were most active. The MIC of tobramycin used in combination with carbenicillin or cephaloridine decreased 3-30 times. In treatment of albino mice with sepsis caused by Providencia stuartii it was possible to lower 2-8 times the dose of tobramycin used in combination with carbenicillin or cefazolin.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002228:Carbenicillin / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D051379:Mice; D008826:Microbial Sensitivity Tests; D011512:Proteus Infections / Q000188:drug therapy*; D011532:Providencia / Q000187:drug effects; D014031:Tobramycin / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002228:Carbenicillin; D014031:Tobramycin
Effektivnost' kombinirovannogo primeneniia tobramitsina s karbenitsillinom ili tsefalosporinami pri éksperimental'noĭ infektsii u mysheĭ, vyzvannoĭ Providencia stuartii.