Lack of response to bronchodilator of airway obstruction after mechanical ventilation in the newborn.
Thoracic gas volume (TGV) and specific airway conductance (SGaw) were measured in 6 infants, 21-42 weeks of age, who had been mechanically ventilated during the neonatal period. SGaw was significantly decreased while TGV was normal. Administration of a nebulized beta 2-sympathomimetic stimulant did not improve lung function. It is concluded that inhalation of beta 2 stimulant drugs is not effective in improving airway obstruction in infants with postventilation-elevated airway resistance and that this is likely to be of structural origin.
D000420:Albuterol / Q000494:pharmacology; D001993:Bronchodilator Agents / Q000494:pharmacology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008173:Lung Diseases, Obstructive / Q000209:etiology / Q000503:physiopathology*; D008176:Lung Volume Measurements; D012123:Pulmonary Ventilation / Q000187:drug effects; D012119:Respiration / Q000187:drug effects*; D012121:Respiration, Artificial / Q000009:adverse effects*; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*
D001993:Bronchodilator Agents; D000420:Albuterol