Monoamine-oxidizing enzymes in human pregnancy.
The activity of benzylamine oxidase (BzAO) was investigated in human maternal blood at all stages of gestation, including parturition, as well as in the puerperium. In addition, BzAO and monoamine oxidase (MAO) A and B activities were assayed in amniotic fluid, placenta, placental vessels and umbilical vessels. No correlation was found between BzAO values in maternal blood and fetal growth. Highly significant variations in maternal plasma BzAO activity were seen by the end of the first trimester, at parturition and at 6-72 h post-partum. The predominance of MAO A in placenta was again confirmed, whereas in vascular tissue and amniotic fluid, BzAO was clearly preponderant; in the latter, no MAO A activity could be detected. Placental vessels showed significantly higher MAO A activity than umbilical vessels. BzAO and what appears to be a true, soluble MAO B were demonstrated in amniotic fluid. The physiological implications of these findings are discussed.
D000653:Amniotic Fluid / Q000378:metabolism; D001595:Benzylamine Oxidase / Q000378:metabolism*; D001808:Blood Vessels / Q000201:enzymology; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006801:Humans; D007743:Labor, Obstetric; D008995:Monoamine Oxidase / Q000097:blood / Q000378:metabolism*; D010920:Placenta / Q000098:blood supply / Q000378:metabolism; D049590:Postpartum Period; D011247:Pregnancy; D014470:Umbilical Cord / Q000098:blood supply
D001595:Benzylamine Oxidase; D008995:Monoamine Oxidase