[Enzymatic hydroxylation of ruthenocene and osmocene by liver microsomes].
In buffer solution (pH 7,4) ruthenocene and osmocene are far more stable than ferrocene. The metallocenes ruthenocene and osmocene are metabolized by microsomes of mouse liver in the presence of NADPH and O2. The Km-values are similar for both metallocenes, the rate of metabolism is higher for osmocene that for ruthenocene.
D000818:Animals; D005296:Ferrous Compounds / Q000378:metabolism; D006900:Hydroxylation; D007700:Kinetics; D000075163:Metallocenes; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism*; D009942:Organometallic Compounds / Q000378:metabolism*; D009992:Osmium / Q000378:metabolism*; D012428:Ruthenium / Q000378:metabolism*; D013329:Structure-Activity Relationship
D005296:Ferrous Compounds; D000075163:Metallocenes; D009942:Organometallic Compounds; C033842:osmocene; C016721:ruthenocene; D009992:Osmium; D012428:Ruthenium; C004998:ferrocene
Enzymatische hydroxylierung von ruthenocen und osmocen durch leber-mikrosomen.