Gastrointestinal response to minute doses of glucagon.
Small doses of glucagon are effective when performing a biphasic gastrointestinal (GI) examination. The authors conducted a controlled double-blind crossover study to determine the optimum and smallest effective doses and the onset and duration of drug action. Fifteen men received a placebo and 0.025, 0.05, 0.1, and 0.2 mg of glucagon intravenously. Hypotonicity of the stomach, duodenum, and small bowel was adequate with 0.1 mg of glucagon. Low-dose glucagon makes the biphasic upper GI examination short and practical. There is no need to delay the second phase of the examination or the small-bowel follow-through.
D000328:Adult; D001466:Barium Sulfate; D004064:Digestive System / Q000000981:diagnostic imaging* / Q000187:drug effects; D004311:Double-Blind Method; D005769:Gastrointestinal Motility / Q000187:drug effects*; D005934:Glucagon / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D013997:Time Factors
D001466:Barium Sulfate; D005934:Glucagon