Antihypertensive actions of isoprenoids.
Specific features of antihypertensive action of two new isoprenoid compounds, i.e. 5-nicotinooxymethyl -gamma - tocopherylnicotinate (NNT) and decaprenoic ethylester (EDP) were studied in rats. NNT and EDP were very similar to each other in their pharmacological features as far as we studied. Both NNT and EDP did not affect blood pressure in normotensive animals but significantly reduced blood pressure in SHR and DOCA/salt hypertensive animals in the acute studies with single dosing of 1 to 10 mg/kg (p.o.). Their antihypertensive action was mild but long-lasting and cumulated by the repeated administration. The chronic administration of NNT and EDP at oral doses of 0.2 and 2 mg/kg once a day completely suppressed the development of hypertension in rats unilaterally nephrectomized and treated with DOCA/salt and in SHR which were unilaterally ureter-ligated to accelerate the progress of their genetic hypertension. The mechanism of their antihypertensive action remains to be solved.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D003900:Desoxycorticosterone / Q000633:toxicity; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013729:Terpenes / Q000494:pharmacology*; D024505:Tocopherols; D014451:Ubiquinone / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology
D000959:Antihypertensive Agents; D013729:Terpenes; D014451:Ubiquinone; D014810:Vitamin E; D003900:Desoxycorticosterone; C034417:5-nicotinooxymethyl-alpha-tocopherylnicotinate; C034418:decaprenoic ethyl ester; D024505:Tocopherols