1,2-diallylhydrazine dihydrochloride carcinogenesis in mice.
Continuous administration of 0.0625% 1,2-diallylhydrazine dihydrochloride in drinking water for life to 6-week-old randomly bred to Swiss mice induced lung tumors. In comparison with the untreated controls, the lung tumor incidence rose from 25 to 80% in the females and from 26 to 80% in the males. The treatment had no apparent effect on the development of other tumor types. Histopathologically, the lesions were classified as adenomas and adenocarcinomas of the lungs. The work is a continuation of our structure activity inquiry concerning the relative carcinogenic potencies of the dialkyl versus the monoalkyl series of hydrazine analogues.
D000230:Adenocarcinoma / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D002273:Carcinogens; D005260:Female; D006834:Hydrazines / Q000008:administration & dosage / Q000633:toxicity*; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000401:mortality; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced
D002273:Carcinogens; D006834:Hydrazines; C033684:1,2-diallylhydrazine