Inhibition of DNA synthesis and cell death.
The association between DNA synthesis inhibition and cell death in mouse L-cells was investigated using the drug hydroxyurea. This drug produces a preferential labelling of low molecular weight DNA and dose-response studies revealed a correlation between this effect and cytoxicity. Investigation of the reassociation kinetics of DNA labelled during hydroxyurea inhibition showed an over-replication of middle repetitive sequences, but the concentration dependence of this effect was quite different to that of cytotoxicity.
D000818:Animals; D002470:Cell Survival; D004261:DNA Replication / Q000187:drug effects*; D006918:Hydroxyurea / Q000494:pharmacology*; D007739:L Cells / Q000166:cytology / Q000378:metabolism*; D008433:Mathematics; D051379:Mice
D006918:Hydroxyurea