[Thiazolidine carboxylic acid toxicity. A review of 78 cases (author's transl)].
Among the calls for information recently received by the French Poison Control Centers, 78 concerned a liver protecting agent, thiazolidine carboxylic acid. In almost every case, doses well above the therapeutic range have provided a status epilepticus. Thus confirming the neurotoxicity of the drug which had been known to the Poison control Centers for the past 10 years. Several patients had also metabolic acidosis, severe hypoglycaemia, or, more scarcely, hyperglycaemia. Seizures convulsions occurred specially in young children whose immature blood-brain barrier allowed penetration into the CSF of thiazolidine carboxylic acid, later metabolized locally into the strongly irritant compound formaldehyde. In view of its toxicity, the drug should never be administered to young children. The usual measures to prevent intoxication should be applied and in case of overdosage the patients should be admitted to hospital for observation. Long-lasting anti-epileptic treatments should be avoided.
D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D051381:Rats; D012189:Retrospective Studies; D013844:Thiazoles / Q000378:metabolism / Q000506:poisoning* / Q000633:toxicity; D053778:Thiazolidines
D013844:Thiazoles; D053778:Thiazolidines; C003438:thiazolidine-4-carboxylic acid
Intoxication par l'acide thiazolide-carboxylique. 78 cas.