Werner's syndrome: twenty-four cases with a review of the Japanese medical literature.
Twenty-four cases of Werner's syndrome were studied to define the clinical manifestations in comparison with those found in a clinical review of 153 cases in the Japanese medical literature. The conspicuous characteristics of the 24 patients were short stature, stocky trunk with thin limbs, low body weight, bird-like or "masked" face, early graying or loss of hair, high-pitched or hoarse voice, bilateral cataracts, and various scleroderma-like signs. Three signs not stressed previously were hyperreflexia, flat feet, and irregular dental development. The onsets and incidences of these manifestations during the seven-year serial study are described.
D000328:Adult; D000368:Aged; D002114:Calcinosis / Q000000981:diagnostic imaging; D002318:Cardiovascular Diseases / Q000209:etiology; D004700:Endocrine System Diseases / Q000209:etiology; D005260:Female; D005413:Flatfoot / Q000209:etiology; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology; D008297:Male; D008310:Malocclusion / Q000209:etiology; D008875:Middle Aged; D010024:Osteoporosis / Q000000981:diagnostic imaging; D010329:Patella / Q000503:physiopathology; D010641:Phenotype; D011859:Radiography; D012871:Skin Diseases / Q000209:etiology; D014898:Werner Syndrome / Q000150:complications / Q000175:diagnosis*