Dihydrotestosterone-induced inhibition of lordosis in estrogen-primed ovariectomized rats following 6-hydroxydopamine or electrolytic septal lesions.
The dose-dependent inhibition of lordosis by 5 alpha-dihydrotestosterone propionate in ovariectomized female rats treated concurrently with estradiol benzoate was attenuated neither by intracranial 6-hydroxydopamine injections which reduced dopamine concentrations by approximately 70% in septum or 75% in both septum and n. accumbens septi nor by electrolytic destruction of the lateral or medial septal nuclei or of both septal nuclei. These results suggest that inhibitory effect of dihydrotestosterone on estrogen-induced lordosis does not critically depend on the mesolimbic dopaminergic innervation of the forebrain or on the septal nuclei.
D000818:Animals; D001921:Brain / Q000502:physiology*; D002369:Castration; D013196:Dihydrotestosterone / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology; D004572:Electrolysis; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006892:Hydroxydopamines / Q000494:pharmacology; D009411:Nerve Endings / Q000187:drug effects; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D006892:Hydroxydopamines; D013196:Dihydrotestosterone; D004958:Estradiol; D004298:Dopamine