title: The in-vitro caffeine contracture test: influence of the muscle histochemical profile on test results.
abstract: In vitro caffeine contracture tests were carried out on whole rat muscle composed primarily of either histochemical type I or type II fibers. Muscles composed primarily of type I fibers developed contractures at lower concentrations of caffeine and had lower caffeine specific concentrations than muscles composed primarily of type II fibers. These findings indicate that the histochemical profile of a muscle can influence the results of the in-vitro caffeine contracture test.
mesh_terms: D000818:Animals; D002110:Caffeine; D006221:Halothane / Q000494:pharmacology; D006651:Histocytochemistry; D008297:Male; D008305:Malignant Hyperthermia / Q000175:diagnosis*; D009119:Muscle Contraction / Q000187:drug effects*; D009132:Muscles / Q000033:anatomy & histology*; D051381:Rats
chemical_list: D002110:Caffeine; D006221:Halothane