title: Sexually dimorphic cerebral asymmetries in 2-deoxy-D-glucose uptake during postnatal development of the rat: correlations with age and relative brain activity.
abstract: Using a modification of the 2-deoxy-D-glucose technique we have studied developmental changes in local cerebral glucose incorporation. The data were analyzed in terms of per cent uptake, relative brain activity and left-right asymmetry for 7 brain regions. We have shown previously that left-right asymmetries exist at birth and now report: (a) that left-right asymmetries change with age, there being both left-to-right and right-to-left maturational gradients in different structures; and (b) that in most brain regions, the more active a structure is relative to the rest of the brain, the more likely that structure is right-biased and vice-versa. Some of these relationships manifest sexual dimorphism. Collectively, these data indicate that there are dynamic relationships between brain activity, brain asymmetry and brain development in the rat.
mesh_terms: D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D004292:Dominance, Cerebral / Q000502:physiology*; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012044:Regression Analysis; D012737:Sex Factors
chemical_list: D003837:Deoxy Sugars; D003847:Deoxyglucose