title: Effect of protamine on plasma ionized calcium in the dog.
abstract: The anaesthetized, heparinized health adult dogs were infused with protamine sulphate 3 mg X kg-1 and plasma ionized calcium was measured. A significant (p less than 0.01) decrease in ionized calcium occurred which preceded the maximal reduction in cardiac output and systemic arterial pressure. The clinical implications of these results are discussed.
mesh_terms: D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000097:blood*; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D004737:Enflurane; D011188:Potassium / Q000097:blood; D011479:Protamines / Q000494:pharmacology*; D012964:Sodium / Q000097:blood
chemical_list: D011479:Protamines; D004737:Enflurane; D012964:Sodium; D011188:Potassium; D002118:Calcium