Inverse correlation between species life span and specific cytochrome P-448 content of cultured fibroblasts.
The quantity and type of microsomal cytochrome P-450 was determined in early passage cultured fibroblasts from six mammalian species of widely differing life spans. The proportion of cytochrome P-450 and P448 varied considerably among species, with the shorter-lived species having a preponderance of cytochrome P-448. There was a good inverse correlation between potential species life span and the specific cytochrome P-448 content of cultured fibroblasts.
D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000378:metabolism; D002417:Cattle; D002478:Cells, Cultured; D019388:Cytochrome P-450 CYP1A2; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D003580:Cytochromes / Q000032:analysis*; D005347:Fibroblasts / Q000201:enzymology; D006801:Humans; D008017:Life Expectancy; D051379:Mice; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D002273:Carcinogens; D003580:Cytochromes; D003577:Cytochrome P-450 Enzyme System; C017170:Cyp1a2 protein, rat; D019388:Cytochrome P-450 CYP1A2