Systemic lupus erythematosus-like syndrome in monkeys fed alfalfa sprouts: role of a nonprotein amino acid.
Hematologic and serologic abnormalities similar to those observed in human systemic lupus erythematosus (SLE) developed in cynomolgus macaques fed alfalfa sprouts. L-Canavanine sulfate, a constituent of alfalfa sprouts, was incorporated into the diet and reactivated the syndrome in monkeys in which an SLE-like syndrome had previously been induced by the ingestion of alfalfa seeds or sprouts.
D000818:Animals; D002172:Canavanine / Q000009:adverse effects*; D004032:Diet; D004195:Disease Models, Animal; D008180:Lupus Erythematosus, Systemic / Q000209:etiology* / Q000276:immunology; D008252:Macaca fascicularis; D000455:Medicago sativa / Q000009:adverse effects*
D002172:Canavanine