Retinoic acid-binding protein in human squamous cell carcinomas of the ORL region.
In some squamous cell carcinomas of the otorhinolaryngologic region with different grades of differentiation, a protein was found that specifically binds vitamin A acid. In 28 of 37 tumors, the retinoic acid-binding sites were found in significant amounts, according to the authors' data. Areas with metastases showed a lower incidence of retinoic acid-binding, whereas in all normal epiglottis and vocal cord tissue specimens the binding was present. The possible significance of the protein-binding for the biologic effect of the vitamin A acid is discussed.
D001665:Binding Sites / Q000187:drug effects; D001667:Binding, Competitive / Q000187:drug effects; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D002499:Centrifugation, Density Gradient; D005050:Etretinate / Q000378:metabolism; D006258:Head and Neck Neoplasms / Q000378:metabolism / Q000556:secondary; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D010038:Otorhinolaryngologic Diseases / Q000378:metabolism*; D011485:Protein Binding; D014212:Tretinoin / Q000378:metabolism*; D014801:Vitamin A / Q000378:metabolism
D014801:Vitamin A; D014212:Tretinoin; D005050:Etretinate