Regional effect of mepyramine on cerebral glucose utilization in conscious rats.
We examined effects of the antihistamine, mepyramine, which occupies cerebral H1-receptors, on regional brain metabolism of glucose in conscious rats. Although glucose utilization by most structures was not significantly affected, in high doses, mepyramine did cause modest, localized reductions in brain areas with both high (ventromedial nucleus of hypothalamus) and low (medial forebrain bundle) densities of histamine H1-receptors.
D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D008297:Male; D011738:Pyrilamine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011968:Receptors, Histamine / Q000378:metabolism*; D011969:Receptors, Histamine H1 / Q000378:metabolism*
D000631:Aminopyridines; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011738:Pyrilamine; D005947:Glucose