[Mechanisms of the protective action of the calcium antagonists corynphar and verapamil in myocardial ischemia and subsequent reperfusion].
Basing on the results of experiments on 145 rats the authors describe 6 principal mechanisms of the protective action of calcium antagonists, verapamil and corynphar, on acute transitory coronary insufficiency. They are a decrease in ATP deficiency in the impairment of the creatinekinase pathway of energy transport and its utilization, activation of myocardial lipid peroxidation, reduction of adrenoreactive properties of the heart and blood hypercoagulation. It is concluded that suppression of calcium ion transport of cardiomyocytes, particularly by the calcium antagonists, is an effective principle of pathogenetic therapy and prophylaxis of cardiac failure in acute transitory coronary insufficiency.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003327:Coronary Disease / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009543:Nifedipine / Q000627:therapeutic use*; D011188:Potassium / Q000378:metabolism; D011725:Pyridines / Q000627:therapeutic use*; D051381:Rats; D012964:Sodium / Q000378:metabolism; D014700:Verapamil / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D011725:Pyridines; D012964:Sodium; D014700:Verapamil; D009543:Nifedipine; D011188:Potassium; D002118:Calcium
Mekhanizmy protektivnogo deĭstviia antagonistov kal'tsiia--korinfara i verapamila--pri ishemii i posleduiushcheĭ reperfuzii miokarda.