Severe cardiac and ophthalmologic malformations in an infant exposed to diphenylhydantoin in utero.
A newborn male infant with multiple congenital malformations including lethal cardiac malformations and severe ophthalmic malformations is described. The infant was exposed in utero to hydantoin. There is no other identifiable cause for the malformations apparent in the infant's or his family's history.
D000014:Abnormalities, Drug-Induced / Q000175:diagnosis*; D000015:Abnormalities, Multiple / Q000139:chemically induced*; D000328:Adult; D005128:Eye Diseases / Q000139:chemically induced*; D005260:Female; D006330:Heart Defects, Congenital / Q000139:chemically induced*; D006344:Heart Septal Defects, Atrial / Q000139:chemically induced; D006345:Heart Septal Defects, Ventricular / Q000139:chemically induced; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000139:chemically induced*; D008297:Male; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D010672:Phenytoin / Q000009:adverse effects*; D011247:Pregnancy
D010672:Phenytoin