Steroid receptor proteins in human meningiomas.
Steroid receptor assays play an important role in determining the efficiency of endocrine therapy for patients with breast cancer. Other tumors could also be hormonally dependent and patients with these tumours might also benefit from endocrine manipulation. Thus, patients with meningiomas were tested for the presence or absence of estrogen and progesterone receptors. The results showed that a majority of meningiomas lacked estrogen receptors but contained large amounts of progesterone receptor. Therefore, it should be possible to use antiprogestin therapy in cases where complete surgical resection of meningiomas is not possible.
D000328:Adult; D002499:Centrifugation, Density Gradient; D002848:Chromatography, DEAE-Cellulose; D003600:Cytosol / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008579:Meningioma / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D011987:Receptors, Steroid / Q000032:analysis*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011987:Receptors, Steroid