Sodium transport inhibition by amiloride reduces basolateral membrane potassium conductance in tight epithelia.
In toad and frog urinary bladder, electrophysiological data suggest that inhibition of transepithelial sodium transport by mucosal amiloride results in a decrease in basolateral membrane conductance. These results were confirmed by showing that amiloride addition caused a decrease in basolateral membrane potassium permeability.
D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D001001:Anura; D001693:Biological Transport, Active / Q000187:drug effects; D004848:Epithelium / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D011188:Potassium / Q000502:physiology*; D011719:Pyrazines / Q000494:pharmacology*; D012964:Sodium / Q000502:physiology*; D001743:Urinary Bladder
D011719:Pyrazines; D000584:Amiloride; D012964:Sodium; D011188:Potassium