[Serum results following experimental fracture alignment and thyrocalcitonin treatment (author's transl)].
Serum alkaline phosphatase activity, serum calcium and phosphorus concentrations were determined during bone healing under treatment of thyrocalcitonin. The right tibiae of 160 albino rats were osteotomized. Of these, 80 were treated with thyrocalcitonin. During the 50-day observation period, the calcium level in the thyrocalcitonin-treated sample never differed significantly from that of the control group. However, the alkaline phosphatase activity and the serum phosphorus level significantly differed from the control levels (P less than 0.05) during 4 days of observation. The increased serum alkaline phoshatase activity--a sign of osteoblastic activity--suggests that thyrocalcitonin may aid in osteogenesis and bone healing.
D000469:Alkaline Phosphatase / Q000097:blood*; D000818:Animals; D002116:Calcitonin / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood*; D005593:Fracture Fixation, Internal; D008297:Male; D010758:Phosphorus / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D013978:Tibial Fractures / Q000201:enzymology / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects
D010758:Phosphorus; D002116:Calcitonin; D000469:Alkaline Phosphatase; D002118:Calcium
Klinisch-chemische Serumbefunde nach experimenteller Fraktursetzung und Calcitonin-Behandlung.