Experience with daily immunotherapy in 59 adult allergic patients.
Fifty-nine adult men with seasonal allergic rhinitis received immunotherapy that was administered five to six times per week until maintenance doses were achieved. Immunologic response was monitored with titrated prick skin tests, which revealed increased sensitivity at 2 wk. followed by progressive decline coinciding with a rise in IgG blocking antibody. Specific serum IgE (RAST) did not change. When compared with a group of receiving conventional weekly injections, these subjects required the same number of injections to reach maintenance and had the same incidence of adverse reactions.
D000328:Adult; D000485:Allergens / Q000008:administration & dosage; D001667:Binding, Competitive; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000276:immunology; D007167:Immunotherapy / Q000009:adverse effects; D007273:Injections, Intramuscular; D008297:Male; D011852:Radioallergosorbent Test; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis / Q000628:therapy*; D012882:Skin Tests; D013997:Time Factors
D000485:Allergens; D007074:Immunoglobulin G; D007073:Immunoglobulin E