[Inhibition of free-radical lipid peroxidation in myocardial infarct as affected by strophanthin].
It was shown in experiments on rats with experimental ischemic myocardial infarction that strophanthin inhibits free-radical lipid peroxidation, decreases (in mean and little doses) the ectopic activity of the myocardium, eliminates tachyarrhythmias arising in the presence of coronary occlusion, delays the appearance on the ECG of changes characteristic for acute myocardial infarction. In mean doses, strophanthin decreases the macrosize of the zone of infarction. It is recommended that strophanthin K (in mean and little doses) be included in a combined therapy of myocardial infarction.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005609:Free Radicals; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D013328:Strophanthins / Q000627:therapeutic use*; D013997:Time Factors
D005609:Free Radicals; D008054:Lipid Peroxides; D013328:Strophanthins; C029082:strophanthin K
Tormozhenie perekisnogo svobodnoradikal'nogo okisleniia lipidov pri infarkte miokarda pod vliianiem strofantina.