Novel method of derivatization of an amidinourea (lidamidine) for GLC analysis.
A new quantitative GLC method for analysis of lidamidine hydrochloride (I) was developed. The method was based on derivatization of I to 1-(2,6-dimethylphenyl)-4-methylamino-dihydro-1,3,5-triazin-2-one (II) using dimethylformamide dimethylacetal reagent. Compound II was synthesized and characterized by IR, NMR, mass spectrometry, and elemental analysis. The assigned structure was in agreement with characterization analyses. Cyclization of I to a triazinone using dimethylformamide dimethylacetal reagent presented a new route for the preparation of II.
D002626:Chemistry, Pharmaceutical; D002849:Chromatography, Gas / Q000379:methods; D004355:Drug Stability; D010671:Phenylurea Compounds / Q000032:analysis*
D010671:Phenylurea Compounds; C020918:lidamidine