Reversion of bacteriophage T4rII mutants by high levels of pyrimidine deoxyribonucleosides.
High levels of pyrimidine deoxyribonucleosides, but not purine deoxyribonucleosides, increase the reversion rate of bacteriophage T4rII mutants to r+. This increased reversion rate is not observed when a thymidine kinase mutation is introduced into the bacteriophage, but the high reversion rate persists when the host, E. coli, harbors a thymidine kinase mutation.
D003854:Deoxyribonucleotides / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D009154:Mutation; D011742:Pyrimidine Nucleotides / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013604:T-Phages / Q000187:drug effects / Q000235:genetics*; D013936:Thymidine / Q000494:pharmacology; D013937:Thymidine Kinase / Q000235:genetics; D013941:Thymine / Q000494:pharmacology
D003854:Deoxyribonucleotides; D011742:Pyrimidine Nucleotides; D013937:Thymidine Kinase; D013941:Thymine; D013936:Thymidine