Ovarian development in 46,XY gonadal dysgenesis.
In humans the XY ovary is degenerative, there being scant evidence of persistence of that organ beyond the perinatal period. Here we describe indications of functional ovarian tissue in a 17-year-old female with male karyotype, H-Y+ cellular phenotype, and some signs of the Turner syndrome. Her gonads were removed after the onset of secondary amenorrhea. Histological examination revealed a degenerative right ovary devoid of germ cells and follicles, and a left streak gonad. There was no trace of testicular development in either side.
D000293:Adolescent; D005260:Female; D006059:Gonadal Dysgenesis / Q000473:pathology*; D006061:Gonadal Dysgenesis, 46,XY / Q000235:genetics / Q000473:pathology*; D006182:H-Y Antigen / Q000032:analysis; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D008214:Lymphocytes / Q000032:analysis; D010053:Ovary / Q000473:pathology; D010641:Phenotype
D006182:H-Y Antigen; D006680:HLA Antigens