S-adenosyl-L-methionine antagonizes ethynylestradiol-induced bile cholesterol supersaturation in humans without modifying the estrogen plasma kinetics.
Previous investigations have shown that S-adenosyl-L-methionine antagonizes both cholestasis and bile lipid alterations induced by ethynylestradiol in the rat. Since it is still unknown whether S-adenosyl-L-methionine prevents ethynylestradiol-induced cholesterol supersaturation of bile in humans also and how methynation interferes with plasma ethynylestradiol disappearance, the present study has been carried out. On different days, 5 nonobese subjects with indwelling biliary drainage and reestablished enterohepatic bile circulation received 200 micrograms of intravenous ethynylestradiol or ethynylestradiol plus 200 mg of S-adenosyl-L-methionine intramuscularly. S-adenosyl-L-methionine administration prevented any ethynylestradiol-induced changes in hepatic bile saturation index. Moreover, S-adenosyl-L-methionine did not affect ethylnylestradiol pharmacokinetics which was evaluated in a group of 6 nonobese women receiving 100 micrograms of intravenous ethynylestradiol or ethynylestradiol plus 100 mg of S-adenosyl-L-methionine intramuscularly. These findings indicate that S-adenosyl-L-methionine prevents ethynylestradiol-induced bile lipid changes without interfering with ethynylestradiol kinetics in humans.
D000328:Adult; D001646:Bile / Q000187:drug effects*; D002784:Cholesterol / Q000378:metabolism*; D004997:Ethinyl Estradiol / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007700:Kinetics; D050356:Lipid Metabolism; D008297:Male; D008745:Methylation; D008875:Middle Aged; D012436:S-Adenosylmethionine / Q000494:pharmacology*
D004997:Ethinyl Estradiol; D012436:S-Adenosylmethionine; D002784:Cholesterol