[A contribution to the characterization of incompatibilities of drugs with polyethylene glycols and ethoxylated tensides (author's transl)].
The authors studied by means of differential and equilibrium dialysis the interactions of 9 drugs reported in the literature as incompatible with polyethylene glycols (PEG) with PEG 1000 and a non-ionogenic ethoxylated tenside, Brij 35. The purpose of this study was to investigate how far methods such as differential and equilibrium dialysis are suitable for detecting and predicting incompatibilities. Interactions were observed with most of the drug-adjuvant mixtures under study. Brij 35, which has been used as a model substance of non-ionogenic ethoxylated tensides, proved to have a greater binding activity than PEG 1000. The measurable interactions indicate that many incompatibilities known to be manifest continue to exist in another medium in the form of masked incompatibilities.
D002626:Chemistry, Pharmaceutical; D004344:Drug Incompatibility; D000077423:Polidocanol; D011092:Polyethylene Glycols; D013501:Surface-Active Agents
D013501:Surface-Active Agents; D000077423:Polidocanol; D011092:Polyethylene Glycols
Ein Beitrag zur Charakterisierung von Inkompatibilitäten zwischen Arzneistoffen und Polyethylenglykolen sowie ethoxylierten Tensiden.