title: [Effect of 1 alpha-hydroxycholecalciferol and various dietary phosphorus levels on phosphorus and calcium metabolic indices in rats during hypokinesia].
abstract: The exposure of rats to hypokinesia and a phosphorus-enriched diet (Ca : P = 1:3) was accompanied  by hypocalciemia, hyperphosphatemia, calcium losses from bones and formation of calcificates in the kidneys. The decrease of the phosphorus content in the diet (Ca : P = 1:0.5--1:1) prevented these disorders. The administration of 1 alpha  OHD3 at a dose of 0.025 microgram/day arrested hypokinesia-associated hypocalciemia and bone changes. The administration of 1 alpha OHD3 together with a high phosphorus consumption enhanced nephrolithiasis and induced aortal mediacalcinosis in hypokinetic rats. These data indicate that phosphorus consumption should be reduced in order to prevent disorders in phosphorus-calcium metabolism during hypokinesia. They also suggest that administration of 1 alpha OHD3 may be hazardous in case of excessive phosphorus consumption.
mesh_terms: D000818:Animals; D001011:Aorta / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002136:Calcium, Dietary / Q000008:administration & dosage; D004032:Diet; D006887:Hydroxycholecalciferols / Q000627:therapeutic use*; D007668:Kidney / Q000378:metabolism; D008297:Male; D010758:Phosphorus / Q000008:administration & dosage* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013997:Time Factors
chemical_list: D002136:Calcium, Dietary; D006887:Hydroxycholecalciferols; D010758:Phosphorus; D002118:Calcium; C008088:alfacalcidol
vernacular_title: Vliianie 1 al'fa-oksikholekal'tsiferola i razlichnogo soderzhaniia fosfora v ratsione na nekotorye pokazateli fosforno-kal'tsievogo obmena u krys pri gipokinezii.