Chemoprophylaxis of anaerobic pulmonary infections. An experimental study in rabbits.
Chemoprophylaxis of anaerobic pulmonary infection due to aspiration was studied in a rabbit model with the view of comparing the efficacy of procaine penicillin, clindamycin, chloramphenicol, doxycycline and cefoxitin. The antibiotic treatment was commenced immediately following transtracheal inoculation of a mixture of Bacteroides fragilis, Streptococcus morbillorum, Fusobacterium nucleatum and Eubacterium lentum. Treatment was stopped after 48 h and lungs were examined for evidence of infection on the 10th day. Only clindamycin and carbencillin were highly efficacious in chemoprophylaxis and both drugs prevented pulmonary infection in 7 of 8 (87%) of the animals tested.
D000693:Anaerobiosis; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000517:prevention & control*; D002228:Carbenicillin / Q000627:therapeutic use; D002701:Chloramphenicol / Q000627:therapeutic use; D002981:Clindamycin / Q000627:therapeutic use; D004318:Doxycycline / Q000627:therapeutic use; D008171:Lung Diseases / Q000517:prevention & control*; D008297:Male; D010406:Penicillins / Q000627:therapeutic use; D011817:Rabbits
D000900:Anti-Bacterial Agents; D010406:Penicillins; D002981:Clindamycin; D002701:Chloramphenicol; D002228:Carbenicillin; D004318:Doxycycline