Arterial cholesterol and DNA contents in relation to serum lipids and apolipoproteins. Studies on cystic artery biopsies.
Though various relationships between serum lipoprotein levels and risk for atherosclerotic disease have been shown there are only a few studies on the relationships between serum lipoprotein levels and the lipid contents of the arterial wall. This study presents cholesterol and DNA contents of arterial tissue from biopsies of the cystic artery in 23 patients with uncomplicated cholecystolithiasis. Serum levels of cholesterol, triglycerides, alphalipoprotein cholesterol, apoA-I, A-II and B were determined, and the relationships between artery and serum variables were calculated. There was a positive correlation between serum apoB and the arterial cholesterol, normalized to the DNA contents (r = 0.43, P less than 0.05). There was a tendency towards an inverse correlation between the alpha-lipoprotein cholesterol levels and the arterial cholesterol (r = 0.39, P less than 0.10). There were no significant correlations between serum apoA-I or A-II and the arterial cholesterol contents. These data indicate that deposition of cholesterol in the arterial wall is related to the serum level of apoB, with higher levels of arterial cholesterol at higher serum levels of apoB. Earlier observations of an inverse correlation between alphalipoprotein cholesterol and arterial cholesterol could, however, not be conclusively confirmed.U
D000328:Adult; D000368:Aged; D001053:Apolipoproteins / Q000097:blood*; D001055:Apolipoproteins B; D001158:Arteries / Q000032:analysis*; D001161:Arteriosclerosis / Q000209:etiology; D001706:Biopsy; D002784:Cholesterol / Q000032:analysis*; D004247:DNA / Q000032:analysis*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012306:Risk
D001053:Apolipoproteins; D001055:Apolipoproteins B; D008055:Lipids; D004247:DNA; D002784:Cholesterol