Peptidergic regulation of norepinephrine induced feeding.
The inhibitory effect of a variety of substances on feeding induced by norepinephrine (20 micrograms ICV) was studied. Subcutaneous administration of opiate antagonist, naloxone, inhibited norepinephrine-induced eating at 10 and 5 mg/kg, but not a 1 mg/kg. Intraventricular administration of the GABA antagonist, bicuculline, produced a dose related decrease in food ingestion. The putative satiety hormones, bombesin (10 micrograms/kg; subcutaneously) and cholecystokinin octapeptide (10 micrograms/kg; subcutaneously) also reduced norepinephrine induced eating, as did ICV administration of calcitonin (2 units). Neither thyrotropin-releasing hormone (1 microgram ICV) nor its metabolits, histidyl-proline diketopiperazine (1 microgram ICV) altered norepinephrine-induced feeding. The studies reported here suggest a neuromodulatory role of peptides in the central regulation of norepinephrine-induced feeding.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D002116:Calcitonin / Q000494:pharmacology; D002766:Cholecystokinin / Q000494:pharmacology; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D006728:Hormones / Q000502:physiology; D007031:Hypothalamus / Q000502:physiology*; D007276:Injections, Intraventricular; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009638:Norepinephrine / Q000008:administration & dosage / Q000502:physiology*; D010455:Peptides / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D006728:Hormones; D010455:Peptides; D009270:Naloxone; D002116:Calcitonin; D002766:Cholecystokinin; D009638:Norepinephrine; D001640:Bicuculline