title: Effects of sodium pentachlorophenate on enzymes of energy metabolism in tissues of Notopterus notopterus.
abstract: Effect of sublethal concentrations (0.0083, 0.0055, 0.0041, 0.0033 and 0.0028 mg/l) of sodium penta-chlorophenate (Na-PCP) on the enzymes SDH, PDH and LDH in brain, liver and gills of Notopterus notopterus after 15 ad 30 days exposure were studied. SDH and PDH were inhibited, and LDH were stimulated significantly at most concentrations. However, changes were maximum (-68.3%, -73.4% and +197.7% for SDH, PDH and LDH, respectively) in brain after 30 days, and minimum (-1.3% and +2.4% for SDH and LDH, respectively) in gills and (-3.4% for PDH) brain after 15 days. Inhibition of SDH and PDH, and the stimulation of LDH activity indicate the development of anaerobic conditions at the cellular level in pollutant-stressed fish.
mesh_terms: D000818:Animals; D002733:Chlorophenols / Q000633:toxicity*; D004734:Energy Metabolism / Q000187:drug effects*; D005399:Fishes / Q000378:metabolism*; D007770:L-Lactate Dehydrogenase / Q000032:analysis*; D010416:Pentachlorophenol / Q000633:toxicity*; D011768:Pyruvate Dehydrogenase Complex / Q000037:antagonists & inhibitors; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors
chemical_list: D002733:Chlorophenols; D011768:Pyruvate Dehydrogenase Complex; D010416:Pentachlorophenol; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase