The effect of prostaglandin inhibitors on wound contraction and the myofibroblast.
The production and smooth muscle-like activity of the myofibroblast do not appear to be diminished in a granulating wound treated with prostaglandin inhibitors. Prostaglandins are mediators of inflammation and smooth-muscle stimulants, but inhibition of the prostaglandins and their precursors failed to alter the course of wound contraction and, by inference, the activity of the myofibroblast in this experimental model.
D015117:5,8,11,14-Eicosatetraynoic Acid / Q000494:pharmacology; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects / Q000648:ultrastructure; D006097:Granulation Tissue / Q000187:drug effects*; D007279:Injections, Subcutaneous; D008297:Male; D011239:Prednisolone / Q000494:pharmacology; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D051381:Rats; D014945:Wound Healing / Q000187:drug effects*
D011448:Prostaglandin Antagonists; D015117:5,8,11,14-Eicosatetraynoic Acid; D011239:Prednisolone; D001241:Aspirin