The influence in rabbits and rats of gamma-acetylenic GABA on seizures generated by pentylenetetrazol.
The effect of gamma-acetylenic GABA (GAG), an inhibitor of GABA-transaminase, on epileptic seizures induced by pentylenetetrazol (PTZ) was studied. GAG administered 30 min before PTZ inhibited the development of behavioral seizures in the rat. This effect was not observed when GAG was administered 120 min prior to PTZ. In the rabbit, GAG given 120 min before PTZ blocked the development of behavioral convulsions, and decreased the intensity of bioelectrical seizure activity. The above results indicate that GAG can protect rat and rabbits against the PTZ-induced seizures.
D000480:Alkynes; D000614:Aminocaproates / Q000627:therapeutic use*; D000818:Animals; D004569:Electroencephalography; D010433:Pentylenetetrazole; D011817:Rabbits / Q000502:physiology*; D051381:Rats / Q000502:physiology*; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*
D000480:Alkynes; D000614:Aminocaproates; C013785:4-amino-5-hexynoic acid; D010433:Pentylenetetrazole