Influence or age and sex on the kinetics of intravenously administered L-phenylalanine.
We studied the kinetics of intravenously administered L-phenylalanine with respect to the effect of age and sex, using a two-compartment model. We found that the volume of the peripheral compartment and total body clearance decrease with age. The sex-related influence was less obvious when distribution volumes and total body clearance were corrected for differences in body size. We emphasize the necessity of having age-matched control subjects in kinetic studies.
D000328:Adult; D000367:Age Factors; D000368:Aged; D001835:Body Weight; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010649:Phenylalanine / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D012737:Sex Factors
D010649:Phenylalanine