title: Canine parvovirus infection potentiates canine distemper encephalitis attributable to modified live-virus vaccine.
abstract: Twelve gnotobiotic dogs from 2 litters were allotted to 3 groups. Group A dogs received a modified-live polyvalent (canine distemper, adenovirus type 2, and parainfluenza virus and Leptospira -canicola-icterohemorrhagiae bacterin) vaccine 3 days prior to oral inoculation with canine parvovirus (CPV). Group B dogs received CPV alone. Group C dogs received 1 dose of vaccine only. In none of the 9 CPV-inoculated dogs did clinical signs of CPV infection develop, although high serum antibody titers for CPV developed in all of them. However, in 2 of the 5 CPV-inoculated vaccinates, canine distemper virus encephalomyelitis subsequently developed. The results suggested that CPV exerts an immunomodulating effect on canine immune responses and may be responsible for vaccination failures in dogs.
mesh_terms: D000818:Animals; D004217:Distemper Virus, Canine / Q000276:immunology; D004283:Dog Diseases / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D004285:Dogs; D004660:Encephalitis / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D010321:Parvoviridae; D014765:Viral Vaccines / Q000009:adverse effects; D014777:Virus Diseases / Q000150:complications / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*
chemical_list: D014765:Viral Vaccines