Metabolism of cortoic acids in man.
Administrated radioactive tracers of beta-cortolic or beta-cortolonic acids are excreted mostly unchanged, without significant alteration of the molecule at C-11 or C-20; a minor amount of cleavage to C-20 etianic acids occurs. Evidence was obtained for possible noncovalent complexing of the steroid acids to macromolecular components present in the enzyme preparation for hydrolysis of the urinary glucuronides; this complex can be dissociated by acidification to pH 2, and the acidic metabolites can then be readily extracted. The findings suggest that beta-cortoic acids are essentially terminal metabolites in man.
D000328:Adult; D002852:Chromatography, Ion Exchange; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000652:urine; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction
C007135:cortolonic acid; C007134:cortolic acid; D006854:Hydrocortisone