title: Volume-adjusted maximal mid-expiratory flow (Iso-volume FEF25-75%): definition of "Significant" responsiveness in healthy, normal subjects.
abstract: Iso-volume FEF25-75% was evaluated in 30 non-smoking, healthy subjects (16-58 years) to define the percentage change over baseline required for responsiveness to inhaled bronchodilators using this measurement to be significant. The mean percentage change from baseline for Iso-volume FEF25-75% was 15.3% +/- 17.2% (1 SD). Improvement of greater than 49.6% (mean +/- 2 SD) over baseline is required for the change reflected by the Iso-volume FEF25-75% to be significant.
mesh_terms: D000293:Adolescent; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects*; D000605:Amino Alcohols / Q000494:pharmacology*; D001993:Bronchodilator Agents / Q000494:pharmacology*; D005541:Forced Expiratory Volume; D006801:Humans; D007528:Isoetharine / Q000494:pharmacology*; D008433:Mathematics; D008450:Maximal Midexpiratory Flow Rate; D008875:Middle Aged; D014797:Vital Capacity
chemical_list: D000605:Amino Alcohols; D001993:Bronchodilator Agents; D007528:Isoetharine