title: Isolated systolic hypertension in the elderly. Some controversial issues.
abstract: Although systolic hypertension in the elderly has received limited attention, it is associated with increased mortality and morbidity; its is not clear, however, whether it is the elevated blood pressure or the arteriosclerosis, for which it is a marker, that increases the risk. While there are no controlled, prospective trials confirming a reduction in morbidity and mortality with treatment, reduction of the systolic blood pressure will reduce diagnosis of systolic hypertension is clearly established by multiple determinations. Contrary to the opinion of some, the elderly are able to tolerate antihypertensive drugs well when the drugs are administered cautiously in low dosages initially, with small increments.
mesh_terms: D000367:Age Factors; D000368:Aged; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006352:Heart Ventricles / Q000187:drug effects / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D000959:Antihypertensive Agents