Regulatory impairments following selective 6-OHDA lesions of the neostriatum.
6-Hydroxydopamine lesions of the ventrolateral (VLC) but not anteromedial (AMC) caudate-putamen in rats resulted in a greater post-operative reduction in body weight and water intake than seen in animals with sham lesions. Once animals had fully resumed spontaneous food and water intake, a series of regulatory challenges were administered, and the AMC rats showed a reduced enhancement of drinking following injection of hypertonic saline. The results are interpreted in terms of a heterogeneous striatal convergence of nigrostriatal and cortical regulatory mechanisms.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001835:Body Weight; D002421:Caudate Nucleus / Q000502:physiology; D003342:Corpus Striatum / Q000502:physiology*; D004298:Dopamine / Q000502:physiology; D004326:Drinking; D004435:Eating; D008297:Male; D011699:Putamen / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste / Q000502:physiology; D014882:Water-Electrolyte Balance
D004298:Dopamine