Increased levels of IgG4 subclass in 5 patients with acquired respiratory disease.
5 sera from a series of more than 1,000 serum samples from hospitalized patients tested by immunoelectrophoresis were selected for further examination because of a disproportional increase in the anodic part of IgG. A marked polyclonal increase in IgG4 subclass level was detected in each of these sera. While the patients suffered from a variety of diseases (e.g. Loeffler's syndrome, leiomyosarcoma, periarteritis nodosa, chronic bronchitis, and mycosis fungoides, respectively), they all had an acquired respiratory disease as the only common clinical denominator.
D000328:Adult; D000368:Aged; D004406:Dysgammaglobulinemia / Q000150:complications / Q000276:immunology*; D004802:Eosinophilia / Q000150:complications / Q000276:immunology; D006801:Humans; D017098:IgA Deficiency; D007126:Immunoglobulin Allotypes / Q000096:biosynthesis*; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000172:deficiency; D008171:Lung Diseases / Q000276:immunology*; D008175:Lung Neoplasms / Q000150:complications / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000150:complications / Q000276:immunology; D014657:Vasculitis / Q000150:complications / Q000276:immunology
D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007073:Immunoglobulin E