Distribution of S-100 protein outside the central nervous system.
The distribution of S-100 outside the central nervous system in humans and rats was explored using antiserum to S-100 and the peroxidase anti-peroxidase method of Sternberger. In peripheral nerves the Schwann cells and the outermost part of the myelin sheaths were stained; axons were not. In dorsal root ganglia and ganglia of the autonomic nervous system only satellite cells were stained. In the adrenal medulla a considerable number of cells were stained. In all other organs studied Schwann cells and satellite cells of ganglia were the only elements that were stained. We conclude that S-100 could serve as a marker for Schwann cells in situ.
D000313:Adrenal Medulla / Q000378:metabolism; D000818:Animals; D005725:Ganglia, Autonomic / Q000378:metabolism; D005727:Ganglia, Spinal / Q000378:metabolism; D006801:Humans; D009186:Myelin Sheath / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009420:Nervous System / Q000378:metabolism*; D010525:Peripheral Nerves / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D009418:S100 Proteins / Q000378:metabolism*; D012583:Schwann Cells / Q000378:metabolism
D009419:Nerve Tissue Proteins; D009418:S100 Proteins