title: Oral theophylline disposition in cystic fibrosis.
abstract: Theophylline absorption and disposition of CF patients have not been systematically studied. To evaluate these factors in CF subjects, seven CF patients were fasted overnight and administered a dose of aminophylline liquid equivalent to 4 mg/kg of anhydrous theophylline. Liver function tests (SGOT, GGT, alkaline phosphatase) were normal in all seven patients. maximum serum theophylline concentrations occurred between 30 and 60 minutes post-dose in all subjects and ranged from 4.8 to 8.6 mcg/ml. These values are similar to those reported in non-CF subjects for a single 4 mg/kg oral dose. The mean serum half-life of 3.5 hours with a range of 1.2 to 5.0 hours is similar to that reported in non-CF populations. The authors conclude that theophylline elimination (half-lives) in CF patients with normal liver function is similar to those of normal and asthmatic patients. CF patients with clinical liver disease may have a decreased clearance and should be carefully monitored.
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008111:Liver Function Tests; D008297:Male; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use
chemical_list: D013806:Theophylline