Morphine-induced immune thrombocytopenia.
Sudden thrombocytopenia that was temporally related to the administration of morphine sulfate developed in a 23-year-old woman. A morphine-dependent platelet antibody was found in her serum by chromic chloride Cr 51 platelet lysis. The antibody was complement dependent, present in the IgG immunoglobulin fraction, and its drug-dependent platelet lytic activity was demonstrable with several narcotic analgesics in addition to morphine. The antibody activity declined over an eight-month period following recovery from thrombocytopenia. To our knowledge, morphine-induced immune thrombocytopenia has not previously been described.
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D001792:Blood Platelets / Q000276:immunology; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000032:analysis; D009020:Morphine / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000276:immunology
D001323:Autoantibodies; D007518:Isoantibodies; D009020:Morphine