Preparation and screening of some new thioacetals, sulfones, and derivatives of 4-dichloromethylbenzoyl and 4-trichloromethylbenzoyl chloride as potential antimalarials.
The preparation and screening of some potential antimalarials are reported. The new compounds which are inactive as antimalarials are several benzene-, benzyl-, and fluorene thioacetals, beta-disulfones derived from these thioacetals, alpha-chlorobenzyl sulfones, amides, and thioesters derived from 4-dichloromethylbenzoyl chloride and 4-trichloromethylbenzoyl chloride. The known compounds bis(4-aminophenyl)sulfone and 4'-aminophenyl-4-aminobenzene thiolsulfonate also were prepared and showed some antimalarial activity.
D000080:Acetals / Q000138:chemical synthesis* / Q000494:pharmacology; D000330:Aedes / Q000469:parasitology; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis*; D001593:Benzyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D010961:Plasmodium / Q000187:drug effects; D013450:Sulfones / Q000138:chemical synthesis* / Q000494:pharmacology
D000080:Acetals; D000962:Antimalarials; D001593:Benzyl Compounds; D013450:Sulfones