Effect of physostigmine on morphine-induced postoperative pain and somnolence.
The effects of physostigmine 1 mg i.v. were studied on the analgesia, sedation and reduction in respiratory rate induced by morphine 10 mg/60 kg i.v. in 10 patients recovering from surgery. Within 5-10 min, physostigmine abolished the somnolent effect of morphine and restored the respiratory rate to pre-drug values. Analgesia, assessed by an independent observer and by the patient was, if anything, increased by physostigmine. The analeptic effect of physostigmine lasted 40-60 min.
D000328:Adult; D000368:Aged; D006801:Humans; D006993:Hypnotics and Sedatives / Q000037:antagonists & inhibitors*; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy*; D010830:Physostigmine / Q000494:pharmacology* / Q000627:therapeutic use; D012119:Respiration / Q000187:drug effects; D012894:Sleep Stages / Q000187:drug effects*
D006993:Hypnotics and Sedatives; D009020:Morphine; D010830:Physostigmine