Bone aging.
Bone matrix of 28-month-old (senescent) rats, compared with 13-month-old rats, is strikingly deficient in the capacity to induce bone formation. Similarly, implants of senescent matrix into one-month-old, rapidly-growing rats (weanlings) produce more bone than in 13-month-old adult recipients, but not nearly enough to compensate for deficiency in the matrix of senile bone. Matrix prepared from the bone of 13-month-old rats also produces almost no cartilage and significantly lower yields of new bone in 28-month-old (senescent) than 13-month-old rats. These observations suggest that progressive decline in the matrix morphogenetic activity of bone occurs with time in adult life. This decline is a tissue specific index of bone aging, and may contribute to the reduction of bone mass that normally occurs with senescence.
D000367:Age Factors; D000375:Aging; D000818:Animals; D001857:Bone Matrix / Q000166:cytology / Q000637:transplantation; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002356:Cartilage / Q000166:cytology / Q000254:growth & development; D006801:Humans; D008297:Male; D010012:Osteogenesis; D011817:Rabbits; D051381:Rats; D011916:Rats, Inbred F344; D014019:Tissue Donors; D014574:Uronic Acids / Q000378:metabolism
D014574:Uronic Acids; D002118:Calcium