title: Investigation of the butyrophenone tranquilizer azaperone and its main metabolites with the Salmonella/microsome test.
abstract: In previous experiments, azaperone was found to be weakly mutagenic, after metabolic activation, in the Ames assay. In this study, we subjected metabolites found in rat and swine to the Salmonella/microsome test. 5 histidine-auxotrophic strains were used. The main metabolites could be classified as weakly mutagenic substances.
mesh_terms: D000818:Animals; D001376:Azaperone / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology*; D001711:Biotransformation; D002090:Butyrophenones / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000378:metabolism*; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects; D013045:Species Specificity
chemical_list: D002090:Butyrophenones; D009153:Mutagens; D001376:Azaperone