Release of nickel into fluid stored in the reservoir of Dermo-Jets.
Release of nickel into triamcinolone acetonide suspensions stored in the reservoir of a Dermo-Jet was demonstrated by electrothermal atomic absorption spectrometry. Increased urinary nickel excretion was found for three days following intradermal injections (with the Dermo-Jet) of triamcinolone acetonide in patients suffering from alopecia areata. The dimethylglyoxime test showed that the internal rod of the reservoir as well as metallic internal parts of the nozzle leached appreciable amounts of nickel, even before any clinical use.
D000506:Alopecia Areata / Q000188:drug therapy / Q000652:urine; D004340:Drug Contamination / Q000032:analysis*; D004356:Drug Storage; D006801:Humans; D007271:Injections, Intradermal / Q000295:instrumentation*; D009532:Nickel / Q000032:analysis* / Q000652:urine; D010091:Oximes; D013535:Suspensions; D014222:Triamcinolone Acetonide / Q000627:therapeutic use
D010091:Oximes; D013535:Suspensions; C013501:dimethylglyoxime; D009532:Nickel; D014222:Triamcinolone Acetonide