[Thyroid hormones and mitochondrial cytochrome c oxidoreductase activity].
In the experiments on albino male rats it was shown that thyroid hormones, exerting organospecific effect, control both the activity and the amount of cytochrome-c-oxidoreductase in hepatic, renal, cardiac and cerebral mitochondria. In the mechanism of cytochrome-c-oxidoreductase regulation thyroxin effect is likely to be mediated by cytochrome c amount. Supraphysiological thyroxin concentrations exert a direct action on the enzyme, whereas its physiological levels regulate cytochrome-c-oxidase, acting as an inductor.
D000818:Animals; D001921:Brain / Q000201:enzymology; D003579:Cytochrome Reductases / Q000378:metabolism*; D006498:Hepatectomy; D007037:Hypothyroidism / Q000201:enzymology; D066298:In Vitro Techniques; D007668:Kidney / Q000201:enzymology; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology*; D008929:Mitochondria, Heart / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D009245:NADH Dehydrogenase / Q000378:metabolism*; D051381:Rats; D013963:Thyroid Hormones / Q000494:pharmacology*; D013965:Thyroidectomy
D013963:Thyroid Hormones; D003579:Cytochrome Reductases; D009245:NADH Dehydrogenase
Tireoidnye gormony i aktivnost' mitokhondrial' noĭ tsitokhrom-lc-oksidoreduktazy.