New bone formation and parathyroid activity effected by 1 alpha-hydroxyvitamin D3.
Adult male rats reared on a standard diet were treated with peroral dosages of 1 alpha-hydroxyvitamin D3 (1 alpha-OHD3). A rapid effect on the serum calcium level was found; the elevation (compared to untreated controls) occurred as early as two weeks and remained elevated throughout the treatment period. Histomorphometric analysis revealed a decreased resorption rate and increased incorporation of tetracycline after four weeks of 1 alpha-OHD3 treatment. These results were associated with a significant increase of cortical as well as trabecular bone, as well as increased levels of bone hydroxyproline and hexosamines. A clearly significant decrease in the total volume of parathyroids was found after six weeks; this was accompanied by a slight pycnosis of the chief cells, which may account for reduced parathyroid activity.
D000818:Animals; D001862:Bone Resorption / Q000187:drug effects*; D001842:Bone and Bones / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006595:Hexosamines / Q000378:metabolism; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects*; D010118:Oxytetracycline / Q000378:metabolism; D010280:Parathyroid Glands / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D006595:Hexosamines; D006887:Hydroxycholecalciferols; D006909:Hydroxyproline; C008088:alfacalcidol; D010118:Oxytetracycline