The nature of the collagen in hepatic fibrosis in advanced murine schistosomiasis.
Livers from CF 1 mice infected with Schistosoma mansoni, 50 cercariae each, were examined 8 weeks postinfection. The collagen content of the livers was increased about 18-fold over that for normal control animals. Quantitation of the collagen types in pepsin-solubilized collagen showed a change in the ratio of Type I to Type III from 2:1 in normal mice to 1:1 in the fibrotic animals. The change in ratio resulted from a very large accumulation of Type III collagen and, accordingly, may provide an important model for study of the possible reversibility of fibrotic lesion.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002845:Chromatography / Q000379:methods; D003094:Collagen / Q000378:metabolism*; D005260:Female; D008109:Liver Diseases, Parasitic / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000378:metabolism*
D000596:Amino Acids; D003094:Collagen