title: Relationship between formaldehyde-related antibodies and cross-reacting anti-N-like antibodies in patients undergoing chronic haemodialysis.
abstract: An attempt was made to determine the sequence of events leading to the production of two distinct antibodies in patients with chronic renal failure who regularly undergo haemodialysis with formaldehyde-resterilizable dialysis units by Multipoint (UK) or Cordis (USA). A distinct pattern emerged-namely, the production of anti-formaldehyde red cells started about six months after the beginning of haemodialysis treatment. Only when the titre of these antibodies reached 64 or 128 another, apparently cross-reacting, antibody appeared which reacted like an anti-N antibody. A strong direct antiglobulin reaction was found to be positive for formalin-treated red cells after five minutes' contact with specific antibody, indicating a high affinity of the antibody fo the formalin-altered red cell.
mesh_terms: D000906:Antibodies / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis*; D003429:Cross Reactions; D004912:Erythrocytes / Q000276:immunology; D005557:Formaldehyde / Q000276:immunology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000628:therapy; D008951:MNSs Blood-Group System / Q000276:immunology*; D006435:Renal Dialysis
chemical_list: D000906:Antibodies; D001323:Autoantibodies; D008951:MNSs Blood-Group System; D005557:Formaldehyde