title: Strain differences in recovery from sensorimotor neglect after unilateral globus pallidus lesions in mice.
abstract: Recovery of somatosensory orientation after unilateral electrolytic lesions of globus pallidus was studied in two inbred strains of mice (C57BL/6, Sec 1/ReJ). During the first four post-lesion days mice of both strains did not react to tactile stimuli (von Frey hair of 2 g intensity) applied to the thorax area contralateral to the lesion. Successively, there was a gradual replacement by non-oriented activation and incomplete oriented responses, followed by normal precise orientation. Recovery of orientation proceeded at a significantly higher rate in C57 mice. After a period of four months C57 mice reached a recovery level of 91% in comparison to 56% of Sec mice. The genotype dependent differences of recovery mechanisms are discussed in terms of plasticity and dopaminergic systems.
mesh_terms: D000818:Animals; D004292:Dominance, Cerebral / Q000502:physiology; D004298:Dopamine / Q000502:physiology; D005838:Genotype; D005917:Globus Pallidus / Q000502:physiology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000502:physiology*; D009416:Nerve Regeneration; D009949:Orientation / Q000502:physiology*; D014110:Touch / Q000502:physiology*
chemical_list: D004298:Dopamine