title: Gastrin-secreting tumor of the duodenum (G-cell apudoma) associated with secondary biliary cirrhosis.
abstract: A middle-aged woman with evidence of chronic cholestasis of several years and no previous abdominal surgery was initially thought to have primary biliary cirrhosis. Clinical evaluation disclosed a well-developed secondary biliary cirrhosis apparently caused by extrahepatic obstruction due to a 1 X 2 cm neoplasm of the periampullary duodenum. Electron microscopy and immunofluorescent studies showed the neoplasm to be a G-cell adenoma. Wide local excision has resolved the biliary obstruction. Bening or slow-growing duodenal tumors, if they involve the ampulla of Vater, may produce prolonged partial extrahepatic obstruction and secondary biliary cirrhosis.
mesh_terms: D000328:Adult; D001079:Apudoma / Q000150:complications* / Q000473:pathology; D002276:Carcinoid Tumor / Q000473:pathology; D004379:Duodenal Neoplasms / Q000150:complications* / Q000473:pathology; D005260:Female; D005755:Gastrins / Q000378:metabolism*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000209:etiology*
chemical_list: D005755:Gastrins