title: Genetic polymorphism of human plasminogen in the Japanese population: new plasminogen variants and relationship between plasminogen phenotypes and their biological activities.
abstract: Genetic polymorphism of human plasminogen in the Japanese population has been described using polyacrylamide gel isoelectric focusing electrophoresis followed by immuno-fixation techniques. New variants PLG1'-1', PLG2'-1, and rare 1 were detected. Fibrinolytic activity per milligram plasminogen of each phenotype, except for PLG1'-1' and PLG1-1' was within the normal range. The PLG1' component was associated with no or less plasminogen activity, but possessed plasminogen antigen. Gene frequencies calculated from 750 individuals were PLG1;09560, PLG2; 0.0113, PLG1'; 0.0233, and PLG2',0.0094; respectively. The distribution of phenotypes fitted the Hardy-Weinberg equilibrium. In order to detect the plasminogen phenotypes the immunofixation technique was more suitable than the zymogram technique.
mesh_terms: D014644:Genetic Variation; D006801:Humans; D007122:Immunoelectrophoresis; D007525:Isoelectric Focusing; D007564:Japan; D010641:Phenotype; D010958:Plasminogen / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D010958:Plasminogen