In vivo and in vitro o-methylation of 1-(3,4-dihydroxyphenyl)-2-(n-propyl-amino) propane - an intermediate in N-(N-propyl) amphetamine metabolism.
In vitro metabolism of 1-(3,4-dihydroxyphenyl)-2-(n-propylamino)-propane (Id) by rat liver cytosol in the presence of S-adenosyl-L-methyl-methionine produced almost quantitatively the corresponding 3-methoxy metabolite. 1-(4-Hydroxy-3-methoxyphenyl)-2-(n-propylamino) propane was also recovered from the urine of rats dosed with the catecholamine (Id).
D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism*; D003913:Dextroamphetamine / Q000031:analogs & derivatives* / Q000378:metabolism; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D008745:Methylation; D051381:Rats; D011919:Rats, Inbred Strains
D002395:Catecholamines; C029115:d-N-propylamphetamine; C034548:1-(3,4-dihydroxyphenyl)-2-(n-propylamino)propane; D003913:Dextroamphetamine