title: [Leg disorders--disorders of blood supply. The effect of Essaven ultra in chronic venous insufficiency].
abstract: An open controlled study was performed over a period of 8 weeks to evaluate the effect of Essaven ultra capsules versus placebo in a total of 60 patients suffering from chronic venous insufficiency. Statistical analysis was performed on 29 patients on the active drug (one dropout) and on 25 patients on placebo (5 dropouts). Apart from patients' statements circumference measurements taken of 3 leg segments were used to assess the results of the treatment. In the patients on the active drug there were significant reductions of circumference in the three leg segments (ankle, calf and knee joint) while, in part of the patients on placebo, leg circumference was significantly increased. In the group on active treatment subjective symptoms were also significantly improved in comparison with the controls. The test drug was very well tolerated.
mesh_terms: D000886:Anthropometry; D004338:Drug Combinations / Q000627:therapeutic use; D004341:Drug Evaluation; D004928:Escin / Q000627:therapeutic use*; D005260:Female; D005419:Flavonoids / Q000627:therapeutic use*; D006569:Hesperidin / Q000627:therapeutic use*; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D012503:Saponins / Q000627:therapeutic use*; D014689:Venous Insufficiency / Q000188:drug therapy*
chemical_list: D004338:Drug Combinations; D005419:Flavonoids; D010713:Phosphatidylcholines; D012503:Saponins; D004928:Escin; C013521:essaven; D006569:Hesperidin
vernacular_title: Beinbeschwerden--Durchblutungsstörungen.