Glucocorticoid receptors, clinical characteristics, and implications for prognosis in chronic lymphocytic leukemia.
The cytoplasmic glucocorticoid-receptor (GR) content was analyzed in peripheral leukocytes from 52 nonselected patients with chronic lymphocytic leukemia (CLL). Forty-six patients had measurable GR levels. Six patients lacking measurable GR and seven of eight patients with a low GR content had inactive disease. However, there was no significant difference in average GR content between patients with progressive or nonprogressive disease. Twelve GR-positive patients were treated with prednisolone as the sole medication. Seven patients responded, some in several treatment sessions. There was no correlation between GR-content and clinical response. Thus, in our experience, cytoplasmic GR measurement has only limited predictive value.
D006801:Humans; D007945:Leukemia, Lymphoid / Q000032:analysis* / Q000175:diagnosis / Q000188:drug therapy; D007958:Leukocyte Count; D011239:Prednisolone / Q000627:therapeutic use; D011379:Prognosis; D011965:Receptors, Glucocorticoid / Q000032:analysis*; D011987:Receptors, Steroid / Q000032:analysis*
D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D011239:Prednisolone