[Effect of contrast agents on the iodine-absorbing function of the thyroid gland].
Radiographic contrast agents (RCA) cause a profound and long-term blockade of iodine-absorption thyroid function. It was ascertained that the thyroid gland binds both iodine that splits off from a RCA and the agent itself. The changes were found in 125I-iodine binding by the thyroid gland after preadministering the hepatotropic poison CCl4 and the liver function stimulant phenobarbital. Antithyroid action of RCA is accounted for the interaction of the thyroid gland with native molecules of RCA and by their deiodination in the liver.
D000042:Absorption; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism; D003287:Contrast Media / Q000506:poisoning*; D003974:Diatrizoate Meglumine / Q000506:poisoning; D007455:Iodine / Q000378:metabolism*; D007462:Iodobenzenes / Q000506:poisoning; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism
D003287:Contrast Media; D007462:Iodobenzenes; C034344:iodoalphionic acid; D003974:Diatrizoate Meglumine; D007455:Iodine; D010634:Phenobarbital
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