The effect of alcohol on the in vitro absorption of estradiol and estrone sulphate in rat intestine.
The intestinal absorption of [3H]-estradiol and [3H]-estrone sulphate was studied by measuring the rate of transport of these estrogens from the mucosal to the serosal side of isolated sacs of rat duodenum. Ethanol, at concentrations of 40 mM or higher, significantly enhanced estradiol while inhibiting estrone sulphate transport. Relatively less estradiol was transported as estrone glucuronide and more as free estrone in the presence of 400 mM ethanol than in control sacs. In contrast, 400 mM ethanol resulted in relatively more estrone sulphate being transported unchanged than in the control.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D004958:Estradiol / Q000378:metabolism*; D004970:Estrone / Q000031:analogs & derivatives* / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D004970:Estrone; D000431:Ethanol; D004958:Estradiol; C017296:estrone sulfate