[Influence of hydrocortisone on the kinetics of 22Na metabolism in rat hippocampus slices].
Kinetics of 22Na metabolism in rat hippocampal slices and its changes after single or 7-day injections of hydrocortisone (HC) were studied with an improved method of compartmental analysis. HC caused a redistribution of Na towards an increase of intracellular fractions. The rate constants of Na transfer through cell membranes increased, the Na influx rate constant enhanced to a greater extent than the efflux one. Both single and week HC administration caused a rise in transmembrane stationary fluxes of sodium. The effects observed were compared with the HC action on 22Na metabolism in slices of the neocortex described earlier.
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D051381:Rats; D012964:Sodium / Q000378:metabolism*
D012964:Sodium; D006854:Hydrocortisone
Vliianie gidrokortizona na kinetiku obmena 22Na v srezakh gippokampa krys.