title: [Biological properties of 11-deoxyprostaglandin E1].
abstract: A study was made of 11-desoxyprostaglandin E1 (11-desoxy-PGE1) effect on bronchial resistance, gastric secretion, indomethacin-induced ulcer in rats and adrenalin-produced lipolysis in rat epididymal adipose tissue in vitro. The drug exerted dose-dependent bronchodilator effect in doses of 1 to 100 micrograms/kg. ED50 was 18.66 micrograms/kg. The bronchodilator effect of 11-desoxy-PGE1 was 46.5 to 50.5% of alupent activity within 60 minutes and 97.8% for a period of 60 to 90 minutes. The drug administration in the presence of bronchial spasm considerably reduces the bronchodilator effect duration (down to 5 to 15 minutes). 11-desoxy-PGE1 produces dose-dependent decrease in gastric secretion (ED50 = 4000 micrograms/kg) and hydrogen ion concentration in rat gastric juice (ED50 = 2000 micrograms/kg). The use of 1-desoxy-PGE1 in rats prior to indomethacin injection protects the gastric mucosa, diminishing erosion number. ED50 was equal to 50 micrograms/kg. The drug exerts inhibitory effect on adrenalin-induced lipolysis of the epididymal adipose tissue in vitro. The most pronounced action of 11-desoxy-PGE1 is its bronchodilator effect manifesting after the minimum dose use (1 microgram/kg).
mesh_terms: D000527:Alprostadil / Q000031:analogs & derivatives*; D000818:Animals; D001980:Bronchi / Q000187:drug effects*; D001993:Bronchodilator Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005750:Gastric Juice / Q000187:drug effects; D005753:Gastric Mucosa / Q000187:drug effects; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects; D013997:Time Factors
chemical_list: D001993:Bronchodilator Agents; D011459:Prostaglandins E, Synthetic; D000527:Alprostadil; C034008:11-deoxyprostaglandin E1
vernacular_title: Issledovanie nekotorykh biologicheskikh svoĭstv 11-dezoksiprostaglandina E1.