Effect of sodium copper chlorophyllin on the formation of calcium oxalate crystals in rat kidney.
We induced the deposition of calcium oxalate crystals in rat kidney by intraperitoneal administration of 4-hydroxy-L-proline or sodium oxalate and studied the amounts and size distribution characteristics of the deposited crystals. Intravenous administration of sodium copper chlorophyllin inhibited the deposition and growth of calcium oxalate crystals induced by 4-hydroxy-L-proline or sodium oxalate. This finding may be of importance in calcium oxalate urolithiasis.
D000818:Animals; D002129:Calcium Oxalate / Q000378:metabolism*; D002734:Chlorophyll / Q000031:analogs & derivatives*; D002735:Chlorophyllides / Q000627:therapeutic use*; D003460:Crystallization; D006909:Hydroxyproline; D007669:Kidney Calculi / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D010070:Oxalates; D051381:Rats
D002735:Chlorophyllides; D010070:Oxalates; D002734:Chlorophyll; D002129:Calcium Oxalate; C007020:chlorophyllin; D006909:Hydroxyproline