Six month inhalation toxicity of fluomine dust.
Fluomine is a cobalt chelate of interest in life support systems of high altitude aircraft. Rats, mice, guinea pigs and dogs were exposed to fluomine particles for a six month period on an industrial-type schedule. Chronic exposure of the dust caused a statistically significant decrease in the mean body weights of the test rats when compared to their respective control group. The dust had irritative effects on the respiratory systems of rats and dogs at the highest exposure level. A concentration of 0.1 mg/m3 is a suggested threshold limit at or below which no serious effects should occur.
D000336:Aerosols; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003035:Cobalt / Q000633:toxicity*; D004285:Dogs; D004391:Dust; D005260:Female; D006128:Growth / Q000187:drug effects*; D006168:Guinea Pigs; D008168:Lung / Q000187:drug effects*; D008297:Male; D051379:Mice; D009942:Organometallic Compounds / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013997:Time Factors
D000336:Aerosols; D004391:Dust; D009942:Organometallic Compounds; D003035:Cobalt; C031275:fluomine