Minocycline in the chemotherapy of murine toxoplasmosis.
The effects of minocycline alone or in combination with sulphadiazine were evaluated against acute murine toxoplasmosis and compared with the efficacy of pyrimethamine and sulphadiazine. The date presented show that mice could be protected from acute toxoplasmosis by minocycline, in spite of using a virulent strain of Toxoplasma gondii, a large inoculum, and a delay in the administration of the drug. Acute toxoplasmic infection in mice could be eradicated by aminocycline--sulphadiazine combination, which was found to be as effective as pyrimethamine--sulphadiazine combination therapy.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D008297:Male; D051379:Mice; D008911:Minocycline / Q000627:therapeutic use*; D011739:Pyrimethamine / Q000627:therapeutic use; D013411:Sulfadiazine / Q000627:therapeutic use; D013754:Tetracyclines / Q000627:therapeutic use*; D014124:Toxoplasmosis, Animal / Q000188:drug therapy*
D013754:Tetracyclines; D013411:Sulfadiazine; D008911:Minocycline; D011739:Pyrimethamine