Normal cortical bone mass in patients after long term coumadin therapy.
Clinical delineation of the warfarin embryopathy and the recent discovery of osteocalcin (a vitamin K-dependent bone protein) suggest that coumadin therapy could adversely affect the skeleton. Using bone densitometry and metacarpal cortical width measurement, we found normal cortical bone mass in 17 adults receiving long term coumadin therapy.
D000328:Adult; D000368:Aged; D001842:Bone and Bones / Q000033:anatomy & histology / Q000187:drug effects*; D003720:Densitometry; D005260:Female; D006801:Humans; D008297:Male; D008663:Metacarpus / Q000033:anatomy & histology; D008875:Middle Aged; D014812:Vitamin K / Q000037:antagonists & inhibitors; D014859:Warfarin / Q000494:pharmacology* / Q000627:therapeutic use
D014812:Vitamin K; D014859:Warfarin