The effect of malonyl-CoA on fatty acid oxidation in rat muscle and liver mitochondria.
The effect of malonyl-CoA on palmitate oxidation was compared for skeletal muscle and liver mitochondria from fed rats and rats starved for 18 and 42 h. The nutritional state did not influence the palmitate oxidation rate by both types of mitochondria. Muscle mitochondria are more sensitive to malonyl-CoA inhibition of palmitate oxidation than are liver mitochondria. Their response is not influenced by the nutritional state, in contrast to that of liver mitochondria. The extent of inhibition was not dependent on the carnitine concentration (above 0.5 mM), but higher at lower palmitate:albumin ratio or palmitate concentration.
D000214:Acyl Coenzyme A / Q000494:pharmacology*; D000818:Animals; D005215:Fasting; D008297:Male; D008316:Malonyl Coenzyme A / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D008931:Mitochondria, Muscle / Q000187:drug effects / Q000378:metabolism*; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000214:Acyl Coenzyme A; D010169:Palmitic Acids; D019308:Palmitic Acid; D008316:Malonyl Coenzyme A