[Vitamin B12 as a biologically active model compound].
A critical review on corrinoid biochemistry and physiology is presented. This includes: chemical synthesis of biologically important organocorrinoids and the correlation between their structures and coenzymatic activity; forms, distribution and transport of physiologically active corrinoids; methylcobalamin- and adenosylcobalamin-dependent enzymatic reactions and their physiological functions; and steric course of the adenosylcobalamin-dependent enzymatic rearrangements. Special attention is paid to the mechanisms of adenosylcobalamin-dependent enzymatic reactions.
D003038:Cobamides / Q000378:metabolism / Q000494:pharmacology; D004798:Enzymes / Q000378:metabolism; D008954:Models, Biological; D013329:Structure-Activity Relationship; D014805:Vitamin B 12 / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000378:metabolism* / Q000494:pharmacology
D003038:Cobamides; D004798:Enzymes; C000913:cobamamide; D014805:Vitamin B 12
Vitamin B12 als biologisch aktive Modellsubstanz.