[Effect of sodium fluoride on succinate dehydrogenase and NADH: cytochrome c-reductase of rat liver mitochondria].
It is established that sodium fluoride inhibits the activity of isolated soluble dehydrogenase and succinate dehydrogenase in the rat liver mitochondria in experiments in vitro. The degree of inhibition depends on the fluoride concentration and period of action. At the same time no changes are observed in the NADH-dehydrogenase activity of the mitochondria in the presence of 100 mM of sodium fluoride. With the intragastric administration of 35 and 24 mg/kg sodium fluoride to animals for 3 and 60 days, respectively, the succinate and NADH-dehydrogenase activities of the rat liver mitochondria lower significantly.
D000818:Animals; D003579:Cytochrome Reductases / Q000378:metabolism*; D005459:Fluorides / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology*; D009245:NADH Dehydrogenase / Q000378:metabolism*; D051381:Rats; D012969:Sodium Fluoride / Q000494:pharmacology*; D013385:Succinate Dehydrogenase / Q000378:metabolism*
D012969:Sodium Fluoride; D013385:Succinate Dehydrogenase; D003579:Cytochrome Reductases; D009245:NADH Dehydrogenase; D005459:Fluorides
Vliianie ftorida natriia na suktsinatdegidrogenazu i NADH:tsitokhrom c-reduktazu mitokhondriĭ pecheni krys.