Synthesis and biological investigations of some 5H-1,3,4-oxadiazolo[3,2-a]pyrimidin-5-ones.
The synthesis of some substituted 7-hydroxy-5H-1,3,4-oxadiazolo [3,2-a]pyrimidin-5-ones, a class of bicyclics with unexplored pharmacotoxicological properties, is described. Reacting the 2-phenyl derivative with bis(2,4,5-trichlorophenyl)benzylmalonate afforded a linear pyrano-oxadiazolopyrimidinedione. The assigned structures were verified by IR, 1H-NMR, and mass spectral studies. Six compounds of the series were screened for in vitro antibacterial and antifungal activities. The effect of four compounds on alkaline phosphatase enzyme was also examined.
D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D001419:Bacteria / Q000187:drug effects; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010069:Oxadiazoles / Q000138:chemical synthesis / Q000494:pharmacology; D010920:Placenta / Q000201:enzymology; D011247:Pregnancy; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010069:Oxadiazoles; D011744:Pyrimidinones; D000469:Alkaline Phosphatase