Doisynolic acids: potent estrogens with very low affinity for estrogen receptors.
Doisynolic acids are alkaline degradation products of steroidal estrogens. While these doisynolic acids are potent estrogens, some being more estrogenic than estradiol itself, they bind to cytoplasmic estrogen receptors only feebly compared with estradiol.
D000818:Animals; D003600:Cytosol / Q000378:metabolism; D004963:Estrenes / Q000378:metabolism* / Q000494:pharmacology; D004967:Estrogens / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D011817:Rabbits; D011960:Receptors, Estrogen / Q000378:metabolism*; D012632:Secosteroids / Q000378:metabolism* / Q000494:pharmacology; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000378:metabolism
D004963:Estrenes; D004967:Estrogens; D011960:Receptors, Estrogen; D012632:Secosteroids; C003595:doisynolic acid