title: [Skeletal changes in intermediate beta-thalassemia. Clinical and radiological study].
abstract: Bone changes of varying degree and distribution were observed by the Authors in 10 carriers of beta-thalassaemia intermedia in skull, ribs, hand, elbow and knee bones. When they are present, skeletal changes are the same of homozygous beta-thalassaemia, but less marked and spread. Instead, symptomatology is more homogeneous, usually characterized by mild anaemia and morphological changes of red cells with haemoglobin values in the 6-11 g/dl range, splenomegaly, jaundice, gallstones, crural ulcers. The clinical state goes through the asymptomatic condition to a more severe condition with typical appearance of Cooley's anaemia.
mesh_terms: D000293:Adolescent; D000328:Adult; D001803:Blood Transfusion; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000209:etiology; D011859:Radiography; D013156:Splenectomy; D013789:Thalassemia / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy
vernacular_title: Le alterazioni scheletriche delle beta-talassemie intermedie. Studio clinico e radiologico.