title: Increased fluid pinocytosis, induced by action of platelet-derived growth factor on quiescent arterial smooth muscle cells, does not require increased cholesterol biosynthesis.
abstract: In the current report we provide evidence that the increased rate of cholesterol biosynthesis mediated by platelet-derived growth factor in the cell cycle of monkey (Macaca nemestrina) arterial smooth muscle cells can be separated from the increased rate of fluid pinocytosis using inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
mesh_terms: D000818:Animals; D001158:Arteries; D002784:Cholesterol / Q000096:biosynthesis*; D004247:DNA / Q000096:biosynthesis; D006133:Growth Substances / Q000494:pharmacology*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008148:Lovastatin / Q000031:analogs & derivatives*; D008251:Macaca; D008934:Mitogens / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism*; D009281:Naphthalenes / Q000494:pharmacology; D010873:Pinocytosis / Q000187:drug effects*; D010982:Platelet-Derived Growth Factor
chemical_list: D006133:Growth Substances; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008934:Mitogens; D009281:Naphthalenes; D010982:Platelet-Derived Growth Factor; C012258:mevastatin; D004247:DNA; D002784:Cholesterol; D008148:Lovastatin