title: In vitro coagulant properties of venoms from Australian snakes.
abstract: The procoagulant properties of venous Australian snakes are limited to prothrombin activation. Venoms of Notechis scutatus, Tropidechis carinatus and Pseudechis porphyriacus require phospholipid, calcium and factor V to maximally activate normal prothrombin. Venoms of Pseudonaja textilis and Oxyuranus microlepidotus activate both normal prothrombin and the decarboxy form and do not require co-factors. The actions of the venom of Oxyuranus scutellatus are dependent on concentration.
mesh_terms: D000818:Animals; D001315:Australia; D001777:Blood Coagulation / Q000187:drug effects*; D003029:Coagulants; D004546:Elapid Venoms / Q000633:toxicity*; D006801:Humans; D066298:In Vitro Techniques; D011516:Prothrombin / Q000378:metabolism; D012911:Snakes; D013045:Species Specificity
chemical_list: D003029:Coagulants; D004546:Elapid Venoms; D011516:Prothrombin