Bombesin-like immunoreactivity in developing human lung.
Bombesin-like immunoreactivity (BLI) was detected by a specific radioimmunoassay in extracts of 15 human lungs from fetuses, neonates, infants and children. A higher concentration of lung BLI was found in the fetal/neonatal group (2053.2 +/- 316.3 ng bombesin/g protein, n = 6) compared to the infant/children group (416.3 +/- 64.3 ng/g, n = 9). The peaking of BLI in lungs during the fetal/neonatal period suggests an important function for this peptide in intrauterine life and neonatal adaptation.
D001839:Bombesin / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005333:Fetus / Q000032:analysis*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008168:Lung / Q000032:analysis* / Q000196:embryology; D010455:Peptides / Q000032:analysis*; D011247:Pregnancy; D011863:Radioimmunoassay
D010455:Peptides; D001839:Bombesin