Autoanti-idiotypic lymphocytes in man.
Cells with anti-idiotypic properties were detected 4-6 months following immunization with tetanus toxoid (TT), and were undetectable 10 days following a booster injection. The presence of these cells concomitantly with the normal drop of anti-TT serum titers, and their specific binding to autologous IgG--F(ab')2 anti-TT, suggests a negative feedback at the idiotypic network level.
D000961:Antilymphocyte Serum / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis*; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D013745:Tetanus Toxoid / Q000276:immunology; D013997:Time Factors
D000961:Antilymphocyte Serum; D001323:Autoantibodies; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D007130:Immunoglobulin Idiotypes; D013745:Tetanus Toxoid