Histamine synthesis, imidazole dipeptides, and wound healing.
The relationships among anserine (beta-alanyl-1-methyl-L-histidine), carnosine (beta-alanyl-L-histidine), free histidine, and histamine metabolism were examined in rats wounded by dorsal skin incision. Following wounding, rats were treated with either a histamine liberator (compound 48/80) or a histidine decarboxylase inhibitor (4-imidazolyl-3-amino-2-butanone). The liberator greatly enhanced wounded skin-breaking strength and collagen deposition at the wound site, while the histidine decarboxylase inhibitor reduced skin-breaking strength and collagen deposition. In the second experiment of this study, histamine or histidine treatment was shown to prevent trauma-induced reductions of tissue carnosine but was less effective in ameliorating tissue anserine loss. The results illustrate an interaction between imidazole dipeptides and stress and suggest that carnosine acts as a histidine reserve in relation to histamine synthesis during trauma.
D000818:Animals; D002074:Butanones / Q000494:pharmacology*; D003094:Collagen / Q000096:biosynthesis; D004151:Dipeptides / Q000378:metabolism; D005260:Female; D005264:Femoral Fractures / Q000378:metabolism; D006632:Histamine / Q000096:biosynthesis*; D006639:Histidine / Q000378:metabolism; D006640:Histidine Decarboxylase / Q000037:antagonists & inhibitors; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D009132:Muscles / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000378:metabolism*; D013718:Tensile Strength / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
D002074:Butanones; D004151:Dipeptides; D007093:Imidazoles; C006150:4-imidazolyl-3-amino-2-butanone; D003189:p-Methoxy-N-methylphenethylamine; D006639:Histidine; D006632:Histamine; D003094:Collagen; D006640:Histidine Decarboxylase