Kinetics of a high dose of piretanide in renal failure.
The kinetics of piretanide was studied in patients with renal failure. After oral administration of a high dose of piretanide (96 mg), the pharmacokinetic parameters were: elimination rate constant 0.346 +/- 0.072 h-1, half life 2.00 +/- 0.35 h, and total plasma clearance 119.55 +/- 35.90 ml x min-1. Compared to the values obtained in adults with normal renal function, these results show a decrease in total plasma clearance, but conservation of the metabolic clearance which amounts to 45% of the total clearance in the healthy adult.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D004232:Diuretics / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D006207:Half-Life; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D013449:Sulfonamides / Q000008:administration & dosage / Q000378:metabolism*
D004232:Diuretics; D013449:Sulfonamides; C015451:piretanide