Characterization of serum and liver lipids of gallstone-forming humans.
Liver biopsy and serum specimens obtained from patients with cholesterol gallstones and from a control group were analysed for their different lipids and lipoprotein fractions. The ratio of free cholesterol to esterified cholesterol (CF/CE) was significantly (P less than 0.001) higher in the livers of gallstone-forming patients. There was no significant difference in the levels of total lipids, total cholesterol, phospholipids and glycerides. Beta-lipoprotein fraction (LDL) was higher in gallstone-forming patients. It is concluded that the decrease in esterified cholesterol of gallstone-formers may provide an important clue to an understanding of the physiology and chemistry of stone-formation in humans.
D002769:Cholelithiasis / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D002788:Cholesterol Esters / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D005989:Glycerides / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism
D002788:Cholesterol Esters; D005227:Fatty Acids; D005989:Glycerides; D008055:Lipids; D008077:Lipoproteins, LDL; D010743:Phospholipids; D002784:Cholesterol