title: A new electrophoretic variant of hemoglobin (Ogi) in which a leucine residue is replaced by an arginine residue at position 34 of the alpha-chain.
abstract: Hemoglobin Ogi, in which an arginine is substituted for a leucine residue at position 34 of the alpha-chain, was detected in a Japanese family. Although slightly increased oxygen affinity is associated with this amino acid substitution in the alpha 1 beta 1 contact, it is without obvious deleterious effect on the hematological parameters of the individuals heterozygous for this variant.
mesh_terms: D000595:Amino Acid Sequence; D001120:Arginine; D002675:Child, Preschool; D004588:Electrophoresis, Cellulose Acetate; D004592:Electrophoresis, Starch Gel; D006455:Hemoglobins, Abnormal / Q000378:metabolism*; D006801:Humans; D007930:Leucine; D008297:Male; D010100:Oxygen / Q000097:blood
chemical_list: D006455:Hemoglobins, Abnormal; C035047:hemoglobin Queens; D001120:Arginine; D007930:Leucine; D010100:Oxygen