title: Inhibition, by trichothecene antibiotics, of brain protein synthesis and fever in rabbits.
abstract: 1. To test further the hypothesis that brain protein synthesis is necessary for fever, three structurally similar trichothecene antibiotics were injected into the cerebral ventricles of rabbits. They were 3,15-diacetoxy-12-hydroxytrichothec-9-ene (DAHT), 3,15-didesacetyl-calonectrin (DDAC) and T-2 toxin. Their actions on hypothalamic incorporation of [14C]leucine and fever were compared. 2. DDAC (60 micrograms) and T-2 toxin (10 micrograms) strongly inhibited leucine incorporation and fever. DAHT (60 micrograms) did not diminish fever and had a smaller effect upon leucine incorporation. 3. The findings strengthen considerably earlier suggestions that brain protein synthesis is an essential step in pyrogenesis.
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D007276:Injections, Intraventricular; D007930:Leucine / Q000378:metabolism; D014176:Protein Biosynthesis; D011817:Rabbits; D012717:Sesquiterpenes / Q000494:pharmacology*; D014255:Trichothecenes / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D012717:Sesquiterpenes; D014255:Trichothecenes; D007930:Leucine