Increased 125I-labelled concanavalin A binding to erythrocytes in diabetes mellitus.
Percentage binding of 125 I-labelled concanavalin A to erythrocytes in diabetic patients was significantly higher than that in normal subjects (12.2 +/- 2.8 versus 8.1 +/- 1.8%, mean +/- SD, p less than 0.001). Insulin-dependent diabetic patients showed significantly higher concanavalin A binding than non-insulin-dependent diabetic subjects (15.0 +/- 1.4 versus 11.4 +/- 2.5%, p less than 0.01). There was a highly significant correlation between percentage binding of 125I-labelled concanavalin A and glycosylated haemoglobin.
D000328:Adult; D000368:Aged; D003208:Concanavalin A; D003920:Diabetes Mellitus / Q000097:blood / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011952:Receptors, Concanavalin A / Q000378:metabolism*
D003208:Concanavalin A; D006442:Glycated Hemoglobin; D011952:Receptors, Concanavalin A