Processing of orally absorbed immunogen.
The absorption of immunogen from the adult mouse intestine was demonstrated. This was shown indirectly by the ability of oral doses of a bacterial antigen to prime an animal for an anamnestic, systemic response, and directly by the ability of absorbed material from the plasma in vivo or everted gut sacs in vitro to prime normal mice when injected intravenously. In all cases, the resultant, systemic response in the recipient animals was qualitatively different (presumably due to IgA production) from that obtained in mice primed intravenously with the native antigen.
D000284:Administration, Oral; D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D007070:Immunoglobulin A / Q000096:biosynthesis; D007408:Intestinal Absorption; D051379:Mice; D014734:Vibrio cholerae / Q000276:immunology
D000942:Antigens, Bacterial; D007070:Immunoglobulin A