Changes in the chain length of folylpolyglutamates during liver regeneration.
Partial hepatectomy significantly alters the proportions of folylpolyglutamates of different chain lengths in rat liver. Hexa- and heptaglutamates increase at the expense of tetra- and pentaglutamates. Methyl hexaglutamates account for most of the increase in hexaglutamates, and folates with formyl oxidation-level one-carbon substituents for most of the increase in heptaglutamates. These changes are reversible and believed to represent an element of regulation of one-carbon metabolism.
D000818:Animals; D005492:Folic Acid / Q000031:analogs & derivatives*; D006498:Hepatectomy; D008099:Liver / Q000378:metabolism; D008115:Liver Regeneration; D008297:Male; D011624:Pteroylpolyglutamic Acids / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D011624:Pteroylpolyglutamic Acids; D005492:Folic Acid