title: [Pharmacokinetic study of 3H-stiripentol in rats (author's transl)].
abstract: The radioactive constituents of blood, urine, and bile specimens from Wistar Rats, following intravenous administration of 3H-stiripentol were analyzed, in parallel with samples of: liver, lung, kidneys, testis, heart, brain, cerebellum, and medulla. These investigations yielded the following results: 3H-Stiripentol was quantitatively and rapidly absorbed and metabolized by Wistar rats, due to intense metabolism in the liver. The cerebellum and medulla accumulated radioactivity, which was probably related to the pharmacological effects of this drug.
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D004148:Dioxolanes / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004149:Dioxoles / Q000378:metabolism*; D007700:Kinetics; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
chemical_list: D004148:Dioxolanes; D004149:Dioxoles; C021092:stiripentol
vernacular_title: Etude pharmacocinétique du 3H-stiripentol chez le rat.