Cadeguomycin, a noval nucleoside analog antibiotic. I. The producing organism, production and isolation of cadeguomycin.
An actinomycete strain IM7912T was found to produce cadeguomycin, a new nucleoside analog antibiotic, together with tubercidin. Morphological, cultural and physiological studies showed that the organism belongs to the species Streptomyces hygroscopicus. Comparisons with S. hygroscopicus ISP 5578 revealed that both strains possess similar characteristics except for production of yellow or brownish yellow soluble pigment in some media. Cadeguomycin was isolated from the culture filtrate, separated from tubercidin, and purified.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D002478:Cells, Cultured; D005285:Fermentation; D006151:Guanosine / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*; D013936:Thymidine / Q000378:metabolism; D014372:Tubercidin / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D006151:Guanosine; C034568:cadeguomycin; D014372:Tubercidin; D013936:Thymidine