Termination of mid-trimester pregnancy with intramuscular 15-(S)-15-,methyl-prostaglandin F2 alpha.
Termination of mid-trimester pregnancy was successfully achieved in 30 patients with 15-(S)-15-methyl-PGF 2 alpha administered by repeated intramuscular injections. All patients aborted within 48 hours and the majority (73%) aborted within 24 hours. The mean induction-abortion interval was 19 affected by parity but was marginally shorter in patients at an earlier stage of gestation. The average total dosage of 15-methyl-PGF 2 alpha was 2075 micrograms (or 8,3 injections) per patient. Vomiting (93,9%) and diarrhoea (73,3%) were the only troublesome side-effects but they were not severe and were well tolerated by the patients. The incidence of vomiting was reduced with prophylactic drugs.
D000019:Abortifacient Agents / Q000008:administration & dosage*; D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000028:Abortion, Induced; D000293:Adolescent; D000328:Adult; D002260:Carboprost / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage*; D013997:Time Factors
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D011461:Prostaglandins F, Synthetic; D002260:Carboprost