title: Changes in dopamine release in caudate nuclei and substantia nigrae after electrical stimulation of the posterior interposate nucleus of cat cerebellum.
abstract: The effect of unilateral electrical stimulation of the posterior interposate nucleus of the cerebellum was examined on the activity of the nigro-striatal dopaminergic pathways on both sides of the brain in alpha-chloralose anaesthetized cats. Push-pull cannulae were inserted into both caudate nuclei and both substantia nigrae to measure the release of [3H]dopamine ( [3H]DA) which was continuously synthesized from L-[3,5-3H]tyrosine. The stimulation of the cerebellum induced long-lasting well-organized changes in [3H]DA release in the four structures: an increased release of the neurotransmitter in both the contralateral caudate nucleus and the ipsilateral substantia nigra and a reduction in the release of DA from the ipsilateral caudate nucleus and the contralateral substantia nigra. This finding supports the concept of a functional interaction between the cerebellum and the basal ganglia.
mesh_terms: D000818:Animals; D001931:Brain Mapping; D002415:Cats; D002421:Caudate Nucleus / Q000378:metabolism*; D002529:Cerebellar Nuclei / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism*; D004558:Electric Stimulation; D009434:Neural Pathways / Q000502:physiology; D013378:Substantia Nigra / Q000378:metabolism*
chemical_list: D004298:Dopamine