Placental transfer and tissue localization of [14C]carmoisine in the pregnant rat.
Pregnant Sprague-Dawley rats received [14C]Carmoisine (200 mg/kg; 25 microCi) by gavage, on days 16-19 of gestation. Animals were killed on day 19 of gestation, 2, 16, 64 h after dosing and blood, maternal tissues, amniotic fluids, placentae, fetal membranes and fetuses were analyzed for radioactivity. No evidence for the transplacental transfer of [14C]Carmoisine or its metabolites was obtained. More than 90% of the radioactivity was excreted in feces and urine within 64 h.
D000818:Animals; D005260:Female; D005505:Food Coloring Agents / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D009282:Naphthalenesulfonates / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D005505:Food Coloring Agents; D009282:Naphthalenesulfonates; C006671:azo rubin S