Effects of sex hormones and glucocorticoids on the induction of a drug metabolizing enzyme by phenobarbital in chick embryo.
Elevation of aniline hydroxylase activity by phenobarbital administration was examined in liver of chick embryo pretreated with sex hormones and glucocorticoids. It was found that androgens and progestins did not alter elevation of aniline hydroxylase activity by phenobarbital. However, the phenobarbital effect was prevented by pretreatment with estrogens and enhanced by that of glucocorticoids. These results may indicate that the hormonal environment should be considered when administering agents that induce drug-metabolizing enzymes.
D000728:Androgens / Q000494:pharmacology; D000815:Aniline Hydroxylase / Q000096:biosynthesis; D000818:Animals; D002642:Chick Embryo; D004336:Drug Antagonism; D004790:Enzyme Induction / Q000187:drug effects; D004967:Estrogens / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology*; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D010634:Phenobarbital / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011372:Progestins / Q000494:pharmacology
D000728:Androgens; D004967:Estrogens; D005938:Glucocorticoids; D012739:Gonadal Steroid Hormones; D011372:Progestins; D000815:Aniline Hydroxylase; D010634:Phenobarbital