title: The addition of prazosin to standard triple therapy in the treatment of severe hypertension.
abstract: 1 A small dose of prazosin was added to the treatment regime of sixteen hypertensive patients poorly controlled on a combination of bendrofluazide, hydralazine and propranolol. 2 There was a significant improvement in blood pressure control in all patients at 1 month (P less than 0.01) and this was maintained at 9 months (P less than 0.02). Tolerance to prazosin was not a problem. 3 The addition of prazosin to conventional triple drug therapy produces a further useful fall in blood pressure.
mesh_terms: D000328:Adult; D000368:Aged; D001539:Bendroflumethiazide / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006830:Hydralazine / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011224:Prazosin / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use; D011799:Quinazolines / Q000627:therapeutic use*
chemical_list: D011799:Quinazolines; D006830:Hydralazine; D001539:Bendroflumethiazide; D011433:Propranolol; D011224:Prazosin