Serum concentrations of dihydrotachysterol-2 in the treatment of osteoporosis and hypoparathyroidism.
A method for the quantitative estimation of dihydrotachysterol-2 is described using high performance liquid chromatography coupled to an UV monitor. Since radioactive labelled DHT2 is not available, recovery is based on the assumption that dihydrotachysterol-2 and cholecalciferol behave identically during chromatic procedures. Evidence is presented to support this assumption. In patients treated with DHT2 the serum concentrations of DHT2 rose in proportion to the administered dose.
D002851:Chromatography, High Pressure Liquid; D004097:Dihydrotachysterol / Q000097:blood* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007011:Hypoparathyroidism / Q000097:blood* / Q000188:drug therapy; D008297:Male; D010024:Osteoporosis / Q000097:blood* / Q000188:drug therapy
D004097:Dihydrotachysterol