A variant alkaline phosphatase in renal cell carcinoma.
We report a case of renal cell carcinoma in which up to 32% of the abnormally increased alkaline phosphatase activity in serum was contributed by a variant alkaline phosphatase originating in the primary tumor and its secondary deposits. The variant enzyme was probably an altered form of normal renal alkaline phosphatase. The rest of the alkaline phosphatase activity in the serum was of hepatic origin, but no abnormality of the liver was discovered at autopsy.
D000230:Adenocarcinoma / Q000201:enzymology* / Q000556:secondary; D000469:Alkaline Phosphatase / Q000097:blood / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D007680:Kidney Neoplasms / Q000201:enzymology*; D008099:Liver / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy
D007527:Isoenzymes; D000469:Alkaline Phosphatase