title: Significant progress in dermatologic research since 1977.
abstract: Some active fields of experiment dermatology have been selected to demonstrate the interaction between basic research and clinical dermatology. The identification of the Langerhans cell, the typing of mononuclear cells, and the identification of T cell growth factors have significant implication in contact dermatitis, lymphomas, etc. The group of papovaviruses is better defined in relationship to the type of disease that they produce and its oncogenic potential. Various types of vasculitis are better understood, thanks to research in humoral immunity and complement activation. Melanogenesis and its control by peptides is progressing. New specific proteins have been identified in the connective tissues, and their role has been clarified. Identification of specific proteins of keratinocytes and study of differentiation of these cells have provided useful information and some skin disorders. The control of epidermal cell proliferation and differentiation, through membrane receptors, growth factors, and intracellular enzymes, is progressively giving clues to the understanding of genetic disorders, cancers, the effect of retinoids and phototherapy.
mesh_terms: D003167:Complement Activation; D003880:Dermatology; D006801:Humans; D007111:Immunity, Cellular; D012106:Research; D012867:Skin / Q000254:growth & development / Q000276:immunology; D012871:Skin Diseases / Q000276:immunology*; D012878:Skin Neoplasms / Q000276:immunology