title: Chronic sinusitis in children with respiratory allergy: the role of antimicrobials.
abstract: We evaluated the role of antimicrobials in the treatment of chronic maxillary sinusitis in children with respiratory allergy. Night and day cough, nasal obstruction, rhinorrhea, postnasal seen. Eighty-four children were treated in a double-blind manner with either amoxicillin, erythromycin, trimethoprim-sulfamethoxazole, or an antihistamine decongestant (carbinoxamine maleate-pseudoephedrine HCl). Radiographic and clinical responses were best with amoxicillin, but trimethoprim-sulfamethoxazole was an adequate alternative. This study demonstrates that allergic children with chronic sinusitis with associated chronic respiratory symptoms are likely to respond clinically and radiologically with antimicrobial treatment.
mesh_terms: D000293:Adolescent; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004809:Ephedrine / Q000627:therapeutic use; D004917:Erythromycin / Q000627:therapeutic use; D006801:Humans; D011725:Pyridines / Q000627:therapeutic use; D011859:Radiography; D012130:Respiratory Hypersensitivity / Q000150:complications*; D012852:Sinusitis / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014295:Trimethoprim
chemical_list: D000900:Anti-Bacterial Agents; D011725:Pyridines; D004917:Erythromycin; D000658:Amoxicillin; C004649:carbinoxamine; D014295:Trimethoprim; D004809:Ephedrine; D013420:Sulfamethoxazole