title: Spontaneously metastasizing variants derived from MNU-induced rat mammary tumour.
abstract: N-methyl-N-nitrosourea (MNU) given i.v. to female rats of inbred strains induces mammary adenocarcinomas which are hormone-sensitive but do not spontaneously metastasize (Williams et al., 1981). Tissue culture and selection techniques have been used to derive metastasizing tumours from a mammary tumour induced with MNU in F344/N rats. Histologically, primary tumours and metastases in the lung and lymph nodes were similar. These systems may constitute useful models for the study of breast-cancer metastasis.
mesh_terms: D000230:Adenocarcinoma / Q000032:analysis / Q000139:chemically induced / Q000473:pathology*; D000818:Animals; D005260:Female; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008325:Mammary Neoplasms, Experimental / Q000032:analysis / Q000139:chemically induced / Q000473:pathology*; D008770:Methylnitrosourea; D009362:Neoplasm Metastasis; D051381:Rats; D011916:Rats, Inbred F344; D011960:Receptors, Estrogen / Q000032:analysis
chemical_list: D011960:Receptors, Estrogen; D008770:Methylnitrosourea