Decreased chemotactic activity in activated newborn plasma.
The roles of complement levels and CFI activity in the regulation of chemotactic factor generation were evaluated in newborn and adult plasmas. Plasma samples were obtained from 19 healthy adults, 19 neonates, and 12 3-day-old infants. CFI levels were determined in all samples, chemotactic activity in 15 of the 19 adult and newborn samples, and complement levels in 10 of these 15. Compared to adult plasmas, CFI activity was higher in newborn and infant plasmas and chemotactic activity was lower. A close reciprocal relationship was shown between these two activities (r=-0.958). When corrected for the effects of CFI, the difference in chemotactic activity between newborns and adults disappeared. Mean levels of C1, C3, C4, C5, C3 to C9, CH50, factor B, and properdin were lower in newborn plasmas; however, C2 levels were higher. Partial correlations between these complement components and the chemotactic activity were of small magnitude and statistically not significant. These data suggest that higher CFI activity, rather than lower complement levels, accounts for most of the differences in chemotactic activity between newborn and adult plasma. (J Lab Clin Med 99:331, 1982.)
D000328:Adult; D000375:Aging; D000626:Aminopeptidases; D002630:Chemotactic Factors / Q000037:antagonists & inhibitors* / Q000097:blood; D002633:Chemotaxis; D003165:Complement System Proteins / Q000032:analysis*; D006461:Hemolysis / Q000187:drug effects; D006358:Hot Temperature; D006801:Humans; D007106:Immune Sera / Q000302:isolation & purification; D007231:Infant, Newborn; D008247:Lysosomes / Q000201:enzymology; D010949:Plasma / Q000187:drug effects / Q000502:physiology*; D015054:Zymosan / Q000494:pharmacology
D002630:Chemotactic Factors; D007106:Immune Sera; C010073:chemotactic factor inactivator; D003165:Complement System Proteins; D015054:Zymosan; D000626:Aminopeptidases