Trimethoprim/sulfamethoxazole-associated pseudomembranous colitis.
A case of TMP/SMX-associated pseudomembranous colitis is described in a patient being treated for a urinary tract infection. Pseudomembranes are visualized on proctosigmoidoscopy, and stool cultures identified Clostridium difficile as the causative organism. The patient was treated successfully with oral vancomycin. A review of this infrequently reported adverse reaction to TMP/SMX is presented, emphasizing etiology and treatment.
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D003013:Clostridium / Q000187:drug effects; D004338:Drug Combinations; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced* / Q000382:microbiology; D006801:Humans; D008297:Male; D013420:Sulfamethoxazole / Q000009:adverse effects*; D014295:Trimethoprim / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D014295:Trimethoprim; D013420:Sulfamethoxazole