Transient bradycardia during vespid venom immunotherapy.
A woman developed generalized symptoms of hypersensitivity when she was stung requiring treatment with adrenalin. Intradermal venom skin tests showed immediate hypersensitivity to yellow hornet and white-faced hornet thus fulfilling the criteria to receive appropriate venom immunotherapy. During the course of modified rush immunotherapy with yellow hornet and white-faced hornet venoms, she developed transient but progressive bradycardia necessitating interruption of the venom immunotherapy. Transient bradycardia recurred when venom immunotherapy was resumed but it was possible to reach a maintenance dose of 100 micrograms protein for each venom. Bradycardia has been reported to be induced in experimental animals by oriental hornet venom as well as other venoms, through a direct cholinergic action. It appears that a similar effect may occur in man in susceptible individuals during venom immunotherapy.
D000328:Adult; D001514:Bee Venoms / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects; D001919:Bradycardia / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007299:Insect Bites and Stings / Q000175:diagnosis / Q000188:drug therapy*; D011674:Pulse / Q000187:drug effects; D012882:Skin Tests; D013997:Time Factors; D014862:Wasp Venoms / Q000009:adverse effects* / Q000627:therapeutic use
D001514:Bee Venoms; D014862:Wasp Venoms