title: Differences in metabolism of chemical carcinogens in cultured human epithelial tissues and cells.
abstract: The metabolism of chemical carcinogens has been studied in cultured human bronchus, colon, duodenum, pancreatic duct, and esophagus. Metabolite patterns and carcinogen-DNA adducts are generally qualitatively similar among animal species, individuals within a species, and tissues within an individual. However, wide quantitative differences are observed between individuals in outbred animal species, including humans. These interindividual differences in amounts of carcinogen-DNA adducts and in activities of enzymes that are important in the metabolism of chemical carcinogens are similar in magnitude (10-to 150-fold) to those observed in pharmacogenetic studies of drug metabolism. The role of these differences as risk factors in human cancer is being investigated.
mesh_terms: D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism; D001711:Biotransformation; D001940:Breast / Q000378:metabolism; D001980:Bronchi / Q000378:metabolism; D002273:Carcinogens / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D003106:Colon / Q000378:metabolism; D004386:Duodenum / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism*; D004947:Esophagus / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism; D011467:Prostate / Q000378:metabolism; D012867:Skin / Q000378:metabolism
chemical_list: D002273:Carcinogens; D001189:Aryl Hydrocarbon Hydroxylases