Sister-chromatid exchanges in human lymphocytes treated with 4-chloromethylbiphenyl and benzyl chloride.
At non-inhibitory concentrations, 4CMB and BC both induced small, but dose-related increases in SCE. The dose-response curves gave a highly significant correlation for 4CMB (r = 0.996, P less than 0.001) and a significant correlation for BC (r = 0.757, P less than 0.05) which reflects the relative activities of these substances in bacterial mutation tests.
D001593:Benzyl Compounds / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology*; D002478:Cells, Cultured; D003434:Crossing Over, Genetic / Q000187:drug effects*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D001593:Benzyl Compounds; D001713:Biphenyl Compounds; D009153:Mutagens; C033487:4-chloromethylbiphenyl; C021292:benzyl chloride