Neuron specific in vitro cytotoxicity of sera from patients with amyotrophic lateral sclerosis.
Sera from patients with amyotrophic lateral sclerosis (ALS) were assayed for a neuron-specific cytotoxic effect on long-term organized cultures of neonatal mouse anterior horn segments. Blind studies show that ALS sera when incorporated into the culture media have a greater degree of antineuronal toxicity than sera from patients with other neurological diseases or from family members of ALS patients.
D000690:Amyotrophic Lateral Sclerosis / Q000097:blood*; D000818:Animals; D003602:Cytotoxicity, Immunologic; D006801:Humans; D051379:Mice; D008855:Microscopy, Electron, Scanning; D009474:Neurons / Q000502:physiology* / Q000648:ultrastructure; D013116:Spinal Cord / Q000166:cytology; D013997:Time Factors