Intracellular immunoglobulin distribution of bone marrow plasma cells as a diagnostic aid for primary amyloidosis.
In order to classify the underlying disorder in four patients with biopsy-proven amyloidosis without overt monoclonal gammopathy, the cytoplasmic immunoglobulin (Ig) distribution of bone marrow plasma cells was evaluated using direct immunofluorescence microscopy. This procedure revealed the presence of a monoclonal proliferation of light chain containing plasma cells, and thus led to the diagnosis of immunoglobulin-related amyloidosis.
D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D001798:Blood Proteins / Q000032:analysis; D001853:Bone Marrow / Q000276:immunology* / Q000473:pathology; D003581:Cytodiagnosis; D004587:Electrophoresis, Agar Gel; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011507:Proteinuria
D001798:Blood Proteins; D007136:Immunoglobulins