Effects of levamisole and D-penicillamine on contact sensitivity to oxazolone in rats.
Levamisole, but not D-penicillamine, inhibited the oxazolone delayed hypersensitivity in rats. It was more effective when given locally to the ear (the tissue being challenged with oxazolone) or when injected intraperitoneally 24 h previously. Rats bred for resistance to the dextran anaphylactoid reaction exhibit contact sensitivity to oxazolone even better than rats which respond to clinical dextran.
D000707:Anaphylaxis / Q000276:immunology; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D003877:Dermatitis, Contact / Q000276:immunology*; D005260:Female; D007978:Levamisole / Q000494:pharmacology* / Q000627:therapeutic use; D010080:Oxazoles / Q000276:immunology*; D010081:Oxazolone / Q000276:immunology*; D010396:Penicillamine / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
D010080:Oxazoles; D010081:Oxazolone; D007978:Levamisole; D010396:Penicillamine