Effect of rifampicin on metoprolol and antipyrine kinetics.
1 Effects of rifampicin on the pharmacokinetics of single oral doses of metoprolol and antipyrine are reported. 2 Rifampicin, administered daily for 15 days, reduced the area under the plasma concentration-time curve (AUC) of metoprolol but the rate constant for elimination (beta) of metoprolol from plasma did not alter significantly. 3 Administration of rifampicin for 13 days reduced AUC and increased beta of antipyrine. Thirteen days after discontinuing rifampicin. AUC and beta of antipyrine remained significantly different from the initial values. 4 Some loss of beta-adrenoceptor blockade should be anticipated if rifampicin is administered to patients who are receiving metoprolol.
D000328:Adult; D000983:Antipyrine / Q000378:metabolism*; D004347:Drug Interactions; D006801:Humans; D007700:Kinetics; D008297:Male; D008790:Metoprolol / Q000378:metabolism*; D011412:Propanolamines / Q000378:metabolism*; D012293:Rifampin / Q000494:pharmacology*
D011412:Propanolamines; D008790:Metoprolol; D000983:Antipyrine; D012293:Rifampin