Inhibition of La Crosse virus replication by monensin, monovalent ionophore.
The effect of monensin, a monovalent ionophore, on La Crosse virus particle formation and polypeptide synthesis was examined. Monensin inhibited the release of virus particles (both infectious and non-infectious) from infected BHK-21 cells. Monensin had no detectable effect on the synthesis of polypeptides G1, G2, and N.
D000818:Animals; D002043:Bunyaviridae / Q000187:drug effects*; D002460:Cell Line; D006224:Cricetinae; D002141:Encephalitis Virus, California / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D005663:Furans / Q000494:pharmacology*; D008985:Monensin / Q000494:pharmacology*; D014415:Tunicamycin / Q000494:pharmacology; D014764:Viral Proteins / Q000096:biosynthesis*; D014779:Virus Replication / Q000187:drug effects
D005663:Furans; D014764:Viral Proteins; D014415:Tunicamycin; D008985:Monensin