Preparation of retinoic acid esters of phorbol derivatives.
The synthesis of 12-O-retinoylphorbol-13-acetate (RPA), an incomplete tumor promoter (second stage promoter) is described. The preparation starts with phorbol-13-acetate-20-tritylether which is acylated by a carbodiimide method to yield its 12-retinoate. The latter is detritylated by acidic methanol to give RPA. Following an analogous procedure, the 4-methyl-ether of RPA is prepared from 4-O-methylphorbol-13-acetate-20-tritylether.
D000818:Animals; D001681:Biological Assay; D002273:Carcinogens / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010703:Phorbol Esters / Q000138:chemical synthesis* / Q000494:pharmacology; D010704:Phorbols / Q000138:chemical synthesis*; D012867:Skin / Q000187:drug effects; D013997:Time Factors
D002273:Carcinogens; D010703:Phorbol Esters; D010704:Phorbols; C032974:12-O-retinoylphorbol-13-acetate