[Influence of silymarin and (+)-cyanidanol-3 on the HCB-induced porphyria in rats (author's transl)].
Adult female Wistar rats were fed continuously over a period of 65 days with a diet containing 0.05% hexachlorobenzene (HCB), silymarin (100 mg/kg) or (+)-cyanidanol-3 (150 mg/kg) alone or together with HCB. On day 49 the porphyrins were increased in the cyanidanol-HCB-group in contrast to the silymarin-HCB- and the HCB-group which showed lower levels during the whole experiment. Compared with the other groups--aminolevulinic acid and porphobilinogen were increased in the cyanidanol/HCB-group. Silymarin and cyanidanol had no effect on the formation of experimental porphyria. On the other hand, silymarin is a  stronger inducer of the mixed function monooxygenase system than cyanidanol. The type of the cytochrome P-450 induced by the substances could not be identified with the help of different type-specific inhibitors.
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology*; D002722:Chlorobenzenes / Q000009:adverse effects*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D005415:Flavins / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D006581:Hexachlorobenzene / Q000009:adverse effects*; D011164:Porphyrias / Q000139:chemically induced* / Q000201:enzymology; D011166:Porphyrins / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012838:Silymarin / Q000494:pharmacology*
D001578:Benzopyrans; D002722:Chlorobenzenes; D005415:Flavins; D005419:Flavonoids; D011166:Porphyrins; D012838:Silymarin; D006581:Hexachlorobenzene; D002392:Catechin; D003577:Cytochrome P-450 Enzyme System
Einfluss von Silymarin und (+)-Cyanidanol-3 auf die Hexachlorbenzol (HCB)-induzierte Porphyrie der Ratte.