title: [Antimutagenic action of alpha-tocopherol acetate in carbon tetrachloride poisoning in animals].
abstract: Additional administration of alpha-tocopherol acetate to S57Bl/6 mice and Wistar rats exposed to oral CCl4 under acute and subacute experimental conditions produced no appreciable effect on the frequency of cells with chromosomal aberrations. Additional administration of alpha-tocopherol acetate to S57Bl/6 mice exposed to CCl4 inhalation significantly lessened the frequency of somatic cells with chromosomal aberrations and the frequency of dominant lethals in sexual cells. This attests to a protective action of alpha-tocopherol acetate and confirms the data obtained by other research workers.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy* / Q000235:genetics; D002869:Chromosome Aberrations; D005260:Female; D005799:Genes, Dominant / Q000187:drug effects; D005804:Genes, Lethal / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009153:Mutagens / Q000037:antagonists & inhibitors*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
chemical_list: D009153:Mutagens; D014810:Vitamin E; D024502:alpha-Tocopherol; D024505:Tocopherols
vernacular_title: Izuchenie antimutagennogo deĭstviia al'fa-tokoferola atsetata pri otravlenii zhivotnykh chetyrekhkhloristym uglerodom.