[Effects of propranolol and indomethacin upon urinary hydroxyproline in hyperthyroid patients (author's transl)].
Hydroxyproline excretion was increased by hyperthyroid patients. This increase was related to thyroid hormone levels. Propranolol administration induced a decrease in hydroxyproline excretion and in immunoreactive triiodothyronine. Indometacin administration induced a decrease in urinary excretion of prostaglandins but had no effect on hydroxyproline excretion. These data suggest that the increased bone resorption of hyperthyroidism may involve a catecholamine beta receptor-dependent mechanism and is probably independent of prostaglandins.
D000328:Adult; D000368:Aged; D001862:Bone Resorption / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D006980:Hyperthyroidism / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology*; D011453:Prostaglandins / Q000652:urine; D013974:Thyroxine / Q000097:blood
D011453:Prostaglandins; D010758:Phosphorus; D011433:Propranolol; D013974:Thyroxine; D006909:Hydroxyproline; D002118:Calcium; D007213:Indomethacin
Effets du propranolol et de l'indométacine sur l'hydroxyprolinurie dans l'hyperthyroïdie.