Protection against mercuric chloride nephrotoxicity by cold exposure in rats.
The influence of cold exposure (+ 1 degree C for 24 h) was studied in rats dosed i.p. with 0, 2.5 or 5.0 mumol HgCl2/kg. Cold exposure of controls caused an increased diuresis and solute elimination, except sodium, with almost no variations in urine alkaline phosphatase (ALP) and gammaglutamyl transferase (GGT). Proximal tubule brush border damage was demonstrated by a marked increase in ALP and GGT in HgCl2-dose animals at room temperature. Cold exposure protected against this kidney damage.
D000818:Animals; D003080:Cold Temperature; D005260:Female; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008628:Mercury / Q000633:toxicity*; D011141:Polyuria / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains
D008628:Mercury