New considerations on hydrogen peroxide and related substances as food additives in view of carcinogenicity.
The use of hydrogen peroxide as a labile and safe food preservative in fish cake and boiled noodles has recently been restricted by the Japanese government, since hyperplasia has been found in the duodenum of mice after long-term peroral study. The action of compounds with resembling mode of action, potassium bromate as an improving agent in bread, and sodium chlorate as a weed killer are discussed in this paper in view of developmental and environmental pharmacology.
D000818:Animals; D001959:Bromates / Q000009:adverse effects; D002273:Carcinogens; D002704:Chlorates / Q000009:adverse effects; D004386:Duodenum / Q000473:pathology; D005503:Food Additives / Q000009:adverse effects*; D006861:Hydrogen Peroxide / Q000009:adverse effects*; D006965:Hyperplasia / Q000139:chemically induced; D007564:Japan; D051379:Mice; D009153:Mutagens; D011188:Potassium / Q000009:adverse effects; D051381:Rats
D001959:Bromates; D002273:Carcinogens; D002704:Chlorates; D005503:Food Additives; D009153:Mutagens; C019536:potassium bromate; D006861:Hydrogen Peroxide; D011188:Potassium; C032706:sodium chlorate