Is phenacetin responsible for analgesic nephropathy in New South Wales?
A lifetime history of analgesic consumption was recorded at interview from 91 patients (11 men, 80 women) with a secure diagnosis of renal papillary necrosis, 38 patients (5 men, 33 women) with probable renal papillary necrosis and 223 control subjects from two sources. Consumption of phenacetin-containing analgesics increased the risk of renal papillary necrosis in women some seventeen times over that for non-consumers, but analgesics containing no phenacetin did not confer an increased risk of renal papillary necrosis; in both calculations the confounding effect of taking the other type of analgesic was controlled.
D000328:Adult; D000700:Analgesics / Q000009:adverse effects*; D001315:Australia; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007681:Kidney Papillary Necrosis / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D010615:Phenacetin / Q000009:adverse effects*; D012306:Risk; D012737:Sex Factors
D000700:Analgesics; D004338:Drug Combinations; D010615:Phenacetin