[Effectiveness of treating cervical cancer with preoperative irradiation in the regimen of standard and large fractionated dosages].
A comparative study of the effectiveness of preoperative irradiation with standard (127 females) and large fractionated (163 females) doses was carried out in a group of patients with carcinoma of uterine cervix. Intracavitary or remote-controlled gamma-therapy with large fractionated doses (total dose of 20 Gy) was not followed by overt radiation-induced reactions or complications; it did not present any technical problems and post-operative incidence of complications was 1.5 times less than that in patients who received a total dose of 40-45 Gy during the first stage of combined treatment by standard method. Survival rates for five years were nearly identical in both study groups. More advantage is offered by large-dose fractionated radiation before surgery considering a higher percentage of cured patients and better tolerability.
D000328:Adult; D001918:Brachytherapy / Q000379:methods; D005069:Evaluation Studies as Topic; D005260:Female; D005720:Gamma Rays / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D011300:Preoperative Care / Q000379:methods*; D011867:Radioisotope Teletherapy / Q000379:methods; D011879:Radiotherapy Dosage; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*
Effektivnost' lecheniia raka sheĭki matki s predoperatsionnym oblucheniem v rezhime obychnogo i krupnogo fraktsionirovaniia dozy.