Antitrichomonadal and other biological effects of sugar hydrazones and phenylosazones.
When investigating the possible antitrichomodal effect of 41 phenylsazones, nitro- and dinitro-phenylhydrazones a significant inhibitory effect on multiplication of Trichomonas foetus could be detected in 14 derivatives; eight derivatives were ineffective, other derivatives exhibited only a slight effect. The inhibitory effect of most compounds increased after acetylation. Toxicity of seven effective compounds was determined in vivo. Mutagenicity of these compounds was followed with microorganisms and their cytotoxicity with tumor EAC cells. Two of the effective compounds exhibited also a significant mutagenic effect, three of eight compounds had a pronounced cytotoxic effect, three of eight compounds had a pronounced cytotoxic effect in vitro on the EAC cells, in which they inhibited mainly the incorporation of adenine.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000994:Antitrichomonal Agents / Q000494:pharmacology* / Q000633:toxicity; D002241:Carbohydrates / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000378:metabolism; D002417:Cattle; D006835:Hydrazones / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D014244:Trichomonas / Q000187:drug effects* / Q000254:growth & development
D000970:Antineoplastic Agents; D000994:Antitrichomonal Agents; D002241:Carbohydrates; D006835:Hydrazones