A pharmacokinetic study of mianserin.
The kinetics of mianserin have been evaluated in eight healthy male volunteers following a single oral dose of 60 mg. Plasma and blood concentrations of mianserin were measured by gas chromatography-mass fragmentography. The peak blood concentration observed was 65 microgram/1 at 3 h following the dose. Mean kinetic parameters (and range) calculated from the blood concentrations were: (t1/2)abs 1.1 h (0.3-2.8), (t1/2) alpha 2.5 h (0.9-4.7), (t1/2) beta 21 h (14-33), (Vd) beta 27.5 l/kg (16.8-46.5) and Cloral 0.98 l/kg/h (0.47-1.75). Blood/plasma concentration ratios ranged from 0.50-0.74.
D000284:Administration, Oral; D000328:Adult; D003984:Dibenzazepines / Q000097:blood*; D006801:Humans; D007700:Kinetics; D008297:Male; D008803:Mianserin / Q000008:administration & dosage / Q000097:blood*
D003984:Dibenzazepines; D008803:Mianserin