Reduction in opiate activation after chronic electroconvulsive shock--possible role for endorphins in the behavioral effects of convulsive shock treatment.
Group-housed adult male Sprague-Dawley rats were given a series of 4 exposures to electroconvulsive shock therapy or equivalent handling without shock (sham treatment). Twenty-four hours after the final treatment the rats were given vehicle or one of two doses of morphine intraperitoneally, and motor activity was assessed by remote sensing for 60 min. A significant shift of the normal dose-response curve towards the right was seen after electroshock. This may point to cross-tolerance between electroshock and opiates upon this behavioral measure. The results are consistent with the hypothesis that endorphins may mediate certain aspects of electroshock.
D000818:Animals; D001921:Brain / Q000502:physiology*; D004361:Drug Tolerance; D004565:Electroconvulsive Therapy; D004723:Endorphins / Q000502:physiology*; D008959:Models, Neurological; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D004723:Endorphins; D009020:Morphine