Blood alcohol levels in rats: non-uniform yields from intraperitoneal doses based on body weight.
1 Sprague-Dawley rats (n = 72) weighing from 125 to 450 g were injected intraperitoneally (i.p.) with 16% (w/v) ethanol to provide 1, 2 or 3 g/kg doses. 2 Resulting blood alcohol levels (BALs) demonstrated a general inadequacy of dose/body weight (g/kg) formulations of ethanol to provide uniform BALs in animals of different weights. 3 BAL differences between heavier and lighter rats were not well accounted for by developmental changes in liver weight or alcohol dehydrogenase activity. 4 From the data, a table was derived of more appropriate ethanol injection volumes to produce 0-300 mg% BALs (20 mg% increments) in rats from 100-500 g (10 g increments).
D000818:Animals; D001835:Body Weight; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats / Q000097:blood*; D011919:Rats, Inbred Strains / Q000097:blood
D000431:Ethanol