Delivery of chemotherapeutic agents to the central nervous system.
The blood-brain barrier may prevent passage of effective chemotherapeutic agents to the brain in patients with infections, malignancies, or inborn errors of metabolism. tetanus toxin might be modified and employed as a vehicle to deliver drugs or enzymes to the central nervous system.
D001812:Blood-Brain Barrier; D001927:Brain Diseases / Q000188:drug therapy*; D001932:Brain Neoplasms / Q000188:drug therapy*; D006801:Humans; D013744:Tetanus Toxin / Q000008:administration & dosage* / Q000627:therapeutic use
D013744:Tetanus Toxin