An investigation of DNA-repair phenomena induced by 4-chloromethylbiphenyl (4CMB).
The ability of 4CMB to induce repair phenomena has been investigated in 3 types of assay. No significant unscheduled DNA synthesis or repair replication was found, although the compound gave a weakly positive dose-related response in strand-break assays, with 250 microgram/ml producing significant amounts of strand breaks. These data indicate that 4CMB is a weakly genotoxic agent.
D001713:Biphenyl Compounds / Q000494:pharmacology*; D004260:DNA Repair; D004261:DNA Replication / Q000187:drug effects*; D006367:HeLa Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*
D001713:Biphenyl Compounds; D009153:Mutagens; C033487:4-chloromethylbiphenyl