[Stereological analysis of interneuronal contacts of the rat cerebral cortex in the posthypoxic period].
Hypoxic effect on ultrastructure and amount of synapses in the neocortex has been studied in white rats using the method of selective staining of the interneuronal contacts by means of phosphoric tungsten acid. Asphyxia for 6 min results in an essential decrease in the amount of synapses. Reparation during the posthypoxic period is performed at the expense of hypertrophy of the contacts and activation of neosynapsogenesis. The essential decrease in the number of the synapses (by 31%) is kept 1 month after the asphyxia with a considerable change in the synapsoarchitectonics. Various interrelations of destructive changes in the synapses with hypertrophy and hyperplasy of the contacts in the brain cortex during different time of the restorative period determines the wavy character in the course of the pathological processes.
D000818:Animals; D002540:Cerebral Cortex / Q000473:pathology*; D000860:Hypoxia / Q000473:pathology*; D007395:Interneurons / Q000473:pathology*; D008297:Male; D051381:Rats; D013003:Somatosensory Cortex / Q000473:pathology; D013238:Stereotaxic Techniques; D013569:Synapses / Q000473:pathology; D013997:Time Factors
Stereologicheskiĭ analiz mezhneĭronal'nykh kontaktov kory bol'shogo mozga krys v postgipoksicheskom periode.