[Autoradiographic demonstration of the passage of vincamin through the blood-brain barrier].
Autoradiographies of the brain and of the cerebellum were performed in 8-month old rats after intraperitoneal injection of 3H-labelled vincamine. Only those samples that were processed by freezedrying or by freezesubstitution gave interpretable results. Some specifically labelled cells were found in the molecular layer of the cerebellar cortex as well as in the internal granular and in the deeper layers of the cerebral cortex. they did not belong to the vascular system. It was concluded that vincamine or its metabolites crosses the blood-brain barrier. Any attempt to explain a possible action of the substance on the brain function should thus also consider the cellular components of the central nervous system and not only the haemodynamics of the cerebral circulation.
D000818:Animals; D001345:Autoradiography; D001812:Blood-Brain Barrier; D002540:Cerebral Cortex / Q000378:metabolism; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D014316:Tritium; D014748:Vinca Alkaloids / Q000378:metabolism*; D014749:Vincamine / Q000008:administration & dosage / Q000378:metabolism*
D014748:Vinca Alkaloids; D014316:Tritium; D014749:Vincamine
Autoradiographischer Nachweis für die Passage von Vincamin durch die Blut-Hirn-Schranke.