title: [Biological effects of heavy ion exposure].
abstract: Experiments with accelerated heavy ions may contribute to the understanding of biological radiation action. After outlining the theoretical background experiments are described which were carried out at the UNILAC-machine (Gesellschaft für Schwerionenforschung, Darmstadt, Germany) where ions up to uranium can be accelerated to maximal specific energies of 10 MeV/u. Yeast cells served as biological test systems with the synthesis of ribosomal RNA (r-RNA), colony-forming ability and mutation induction as experimental endpoints. A relationship between action and energy deposition by individual particles can be demonstrated for the inhibition of r-RNA synthesis, in other cases the ion energy plays also an important role indicating that the interaction of sigma-electrons from different particles contributes significantly to the biological effect.
mesh_terms: D004307:Dose-Response Relationship, Radiation; D009154:Mutation; D012335:RNA, Ribosomal / Q000235:genetics / Q000528:radiation effects; D011830:Radiation Effects; D012441:Saccharomyces cerevisiae / Q000528:radiation effects; D014158:Transcription, Genetic / Q000528:radiation effects*
chemical_list: D012335:RNA, Ribosomal
vernacular_title: Biologische Wirkungen der Bestrahlung mit schweren Ionen.