Structural relationships between the endogenous volatile urinary metabolites of experimentally diabetic rats and certain neurotoxins (l).
High resolution glass capillary gas chromatography and GC/MS were utilized to examine qualitative and quantitative variations from normal of urinary volatile metabolites of long-term alloxan and streptozotocin diabetic rats. Volatile metabolites were structurally compared with known neurotoxins to examine any possible relationship between these metabolites and the development of the diabetic polyneuropathy.
D000818:Animals; D003920:Diabetes Mellitus / Q000652:urine*; D003929:Diabetic Neuropathies / Q000209:etiology; D008401:Gas Chromatography-Mass Spectrometry; D007659:Ketones / Q000652:urine; D008297:Male; D008742:Methyl n-Butyl Ketone / Q000652:urine; D009498:Neurotoxins / Q000652:urine*; D011758:Pyrroles / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D014835:Volatilization
D007659:Ketones; D009498:Neurotoxins; D011758:Pyrroles; D008742:Methyl n-Butyl Ketone