title: Pharmacokinetics and efficacy of chlorpheniramine in children.
abstract: Chlorpheniramine is widely used, but there is very little information about its pharmacokinetics and efficacy in children. In 11 patients with allergic rhinitis, ages 6 to 16 yr, we found a mean serum chlorpheniramine half-life of 13.1 +/- 6.3 hr, a mean volume of distribution of 7.0 +/- 2.8 L/kg, and a mean clearance rate of 7.2 +/- 3.2 ml/min/kg. Suppression of symptoms and signs of allergic rhinitis and suppression of the histamine-induced wheal and flare responses occurred when mean serum chlorpheniramine concentration ranged from 2.3 to 12.1 and 4.1 to 10.0 ng/ml, respectively. This combined with the large volume of distribution for the drug, suggest that tissue binding is an important aspect of chlorpheniramine pharmacokinetics.
mesh_terms: D000293:Adolescent; D002648:Child; D002744:Chlorpheniramine / Q000009:adverse effects / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*
chemical_list: D002744:Chlorpheniramine