title: Clinical and pathological study of meningiomas of the first two decades of life.
abstract: The clinical features and pathological materials of 51 cases of histologically verified meningiomas in patients under 21 years of age were reviewed. The age range was 7 to 20 years, with the majority of cases being clustered in the second decade of life. There was virtually a 1:1 sex ratio, with 26 females and 25 males. Thirty-eight patients had intracranial meningiomas, three had intraorbital tumors, and 10 had intraspinal tumors. Twelve patients (24%) had neurofibromatosis. Twenty patients (39%) had tumor recurrence. The cases were subdivided into five histological categories: meningotheliomatous, fibrous, transitional, psammomatous, and papillary. In each case, the clinical course was correlated with histological subtype. The 15-year survival rate in patients with intracranial meningiomas of all types was 68%. Factors adversely affecting survival included infratentorial location, papillary histology, and evidence of brain invasion.
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008579:Meningioma / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology*; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology*; D011859:Radiography; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology*