[Cytostatic action of semisynthetic derivatives of carminomycin].
The cytostatic effect of some semi-synthetic derivatives of carminomycin on the tumor cells of mouse lymphadenosis (NK/Ly was studied in primary suspended cultures. A rapid method developed by the authors was used for determination of the drug cytostatic effect. The method is based on measuring the intensity of 3H-thimidine incorporation into the tumor cells. Simultaneously a method based on estimation of the increase of the total amount of the nucleic acids was used. No derivative superior to the initial drug by the level of the cytostatic effect on the tumor cells was found.
D000818:Animals; D002360:Carubicin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000627:therapeutic use; D004273:DNA, Neoplasm / Q000096:biosynthesis; D003630:Daunorubicin / Q000031:analogs & derivatives*; D003864:Depression, Chemical; D004353:Drug Evaluation, Preclinical / Q000379:methods; D066298:In Vitro Techniques; D008223:Lymphoma / Q000188:drug therapy / Q000378:metabolism; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism; D012334:RNA, Neoplasm / Q000096:biosynthesis
D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D002360:Carubicin; D003630:Daunorubicin
Izuchenie tsitostaticheskogo deĭstviia nekotorykh polusinteticheskikh proizvodnykh karminomitsina.