Creutzfeldt-Jakob disease with demonstration of virus-like particles.
Two kinds of virus-like particles, doughnut-shaped particles and particles with dense core, were discovered in a brain tissue from a patient with Creutzfeldt-Jakob disease. The two types of virus-like particles are similar to immature type C and type C particles. although no direct relationship between Creutzfeldt-Jakob disease and these virus-like particles can be established, these facts may suggest that viruses play some role in the pathogenesis of Creutzfeldt-Jakob disease.
D000368:Aged; D001921:Brain / Q000382:microbiology / Q000473:pathology*; D007562:Creutzfeldt-Jakob Syndrome / Q000209:etiology / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D008297:Male; D014780:Viruses / Q000648:ultrastructure*