Effects of drug pretreatment on antipyrine elimination in the rabbit.
Iproniazid (25-100 mg/kg) produced a marked, dose-related reduction in antipyrine elimination in the rabbit, whereas reductions produced by nitrazepam (32 mg/kg) or SKF 525A (25 and 40 mg/kg) were small. Phenobarbitone, 10 mg/kg chronically, increased antipyrine elimination. The small inhibitory effect of SKF 525A on antipyrine metabolism in the rabbit was unexpected compared to the marked effect in the rat.
D000818:Animals; D000983:Antipyrine / Q000378:metabolism*; D001831:Body Temperature / Q000187:drug effects; D004347:Drug Interactions; D006207:Half-Life; D007490:Iproniazid / Q000494:pharmacology; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D009567:Nitrazepam / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
D009567:Nitrazepam; D011335:Proadifen; D007490:Iproniazid; D000983:Antipyrine