[Use of the physicochemical characteristics of serum albumin for diagnosing ovarian and uterine cancer].
The frequency and causes of diagnostic errors are discussed on the basis of 2,099 case histories of ovarian and uterine tumors. The use of physico-chemical characteristics of serum albumin as an additional means of diagnosis of these diseases in 16 patients and 20 healthy subjects was studied. Patients revealed changes in dispersion of optical rotation of serum albumin which suggest its despiralization. Although being nonspecific, changes in the extent of despiralization vary depending on tumor advancement and gravity of patient's condition. The level of modified serum albumin is also in correlation with tumor process and the patient's state, the highest values being registered at later stages of the disease.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D007120:Immunochemistry; D009905:Optical Rotatory Dispersion; D010051:Ovarian Neoplasms / Q000097:blood*; D012709:Serum Albumin / Q000032:analysis*; D013053:Spectrophotometry / Q000379:methods; D014594:Uterine Neoplasms / Q000097:blood*
D012709:Serum Albumin
Ispol'zovanie fiziko-khimicheskikh kharakteristik syvorotochnogo al'bumina dlia diagnostiki raka iaichnikov i matki.