Effects of anticonvulsants on the formation of gamma-hydroxybutyrate from gamma-aminobutyrate in rat brain.
The conversion of gamma-aminobutyrate (GABA) via succinic semialdehyde to gamma-hydroxybutyrate has been examined in rat brain homogenates. A number of anticonvulsants, including sodium valproate and phenobarbitone, inhibited this metabolic pathway. These results are interpreted in the light of the characteristics of aldehyde reductases known to reduce succinic semialdehyde.
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D006885:Hydroxybutyrates / Q000096:biosynthesis*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012978:Sodium Oxybate; D013329:Structure-Activity Relationship; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis*
D000927:Anticonvulsants; D006885:Hydroxybutyrates; D005680:gamma-Aminobutyric Acid; D012978:Sodium Oxybate; D000612:4-Aminobutyrate Transaminase