Genetics of teratocarcinoma transplantation. III. Genetic control of resistance to F9 tumor formation in allogeneic hosts.
Major F9 allograft resistance of strains C57Bl/6J, CBA/J, C3H/He and AKR/J has been shown to be controlled by a small number of recessive genes. These loci are not linked to H-2. Recombinational analysis suggests that the loci responsible for resistance in these strains are at least partially non-overlapping. These results obtained with the blocked F9 embryonal carcinoma cell line are discussed in relation to those reported for embryonal carcinoma strain PCC3/A/l and OTT6050 embryoid bodies, where recessive resistance is H-2 linked.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics; D007113:Immunity, Innate; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D011995:Recombination, Genetic; D013724:Teratoma / Q000235:genetics* / Q000276:immunology
D006183:H-2 Antigens