Bactericidal capacity of polymorphonuclear leukocytes from patients receiving theophylline therapy.
The capacity of polymorphonuclear leukocytes (PMNs) to kill Staphylococcus aureus strains 502 A was studied in 25 patients receiving theophylline therapy and in normal healthy controls. A significant difference in PMN bactericidal capacity was found between controls and patients with serum theophylline levels higher than 8 micrograms/ml, as determined by high-pressure liquid chromatography. The bactericidal capacity of PMNs from both the patient and control populations was reduced in the presence of theophylline levels above 8 micrograms/ml. In addition, a transient but significant drug-independent reduction was found in the bactericidal capacity of transient but significant drug-independent reduction was found in the bactericidal capacity of PMNs from patients receiving theophylline.
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy; D001770:Blood Bactericidal Activity / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects; D013806:Theophylline / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use
D013806:Theophylline