[Evaluation of the tranquilizing action of neurotropic drugs].
A comprehensive analysis of the cat brain electrograms (EG) by computer has revealed that the derivatives of 1,4-benzodiazepine (chlorodiazepoxide, diazepam) selectivity increase the modules of brain transients within the ranges of 8-12 and 10-12 Hz largely on the EG of the proreal gyrus and paleocortical structures and raise in the same spectral region the level of coherence between biopotentials of the limbic structures, displace the coefficients of asymmetry and excess unidimensional distributions of the instantaneous values of the EG amplitudes towards negative magnitudes. The indicators in question may be used as differential criteria of the tranquilizing effect of neurotropic substances. It is suggested that the increase in the modules of brain transients within the ranges of 8-10, 10-12 Hz during exposure to neurotropic substances is likely to mirror their central GABA-ergic mechanisms and to be an integral electrophysiological correlate of tranquilization as a psychophysiological state.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D002415:Cats; D002707:Chlordiazepoxide / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology*; D004569:Electroencephalography; D005260:Female; D008297:Male; D008620:Meprobamate / Q000494:pharmacology*; D014149:Tranquilizing Agents / Q000494:pharmacology*
D014149:Tranquilizing Agents; D002707:Chlordiazepoxide; D008620:Meprobamate; D003975:Diazepam
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