The effect of hemodialysis on oxygen transport in chronic uremics.
Previous studies from our laboratory suggested a decrease in tissue oxygen delivered during hemodialysis of chronic uremic patients due to an increase in hemoglobin-oxygen affinity, i.e. decrease in P50. This current study was designed to determine whether the changes in cardiac index and/or tissue oxygen extraction could compensate for increases in hemoglobin-oxygen affinity previously observed, so that total tissue delivery was unchanged during hemodialysis. This study demonstrated in patients during a 6-hour hemodialysis that: 1) no change occurs in hemoglobin-oxygen affinity expressed as P50, with unchanging plasma inorganic phosphate and red blood cell pH; 2) increased extraction of oxygen from tissue, measured via (A-V) O2 difference compensates for decreased oxygen delivery due to decreased cardiac output, and although there was no demonstrable change in hemoglobin-oxygen affinity, it would appear that increased tissue extraction of oxygen via other mechanisms should be easily able to compensate for previously reported changes in P50.
D000328:Adult; D001835:Body Weight; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D010108:Oxyhemoglobins / Q000378:metabolism; D010313:Partial Pressure; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood / Q000378:metabolism*
D010108:Oxyhemoglobins