[Mechanism of the toxic action of alcohol on reparative regeneration of the liver].
Administration of ethanol in a dose of 4 g/kg (1/3 of the LD50) from the 1st to the 14th day after partial hepatectomy retards the reparative regeneration of the rat liver. At the cell level this effect is realized at the expense of the reduced cell division followed by mitosis replacement by intracellular pattern of regeneration as hypertrophy and polyploidy of hepatocytes. It is suggested that the revealed mechanism of ethanol toxic effect determines the progressing character of alcoholic liver injury.
D000818:Animals; D000431:Ethanol / Q000633:toxicity*; D008104:Liver Cirrhosis, Alcoholic / Q000209:etiology; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D051381:Rats
D000431:Ethanol
Izuchenie mekhanizma toksicheskogo deĭstviia alkogolia na reparativnuiu regeneratsiiu pecheni.