title: Measurement of pleural pressure in neonates.
abstract: The indirect measurement of pleural pressure in neonates is obtained from measurements of esophageal pressure (Pes) with either a liquid-filled catheter or an esophageal balloon-catheter system. The purpose of this investigation was to assess the validity of the water-filled esophageal catheter by comparing the simultaneous changes in Pes and airway opening pressure (Pao) during occluded respiratory efforts. Equal changes in Pes and Pao under this condition indicate that Pes is a valid measurement of pleural pressure. In six healthy unsedated term neonates (aged 2-3 days) we measured Pes in the lower third of the esophagus with a water-filled catheter of eight French gage (FC), which has a 2-mm internal diameter. During occlusions, changes in Pes and Pao were almost identical in magnitude and timing in each body position studied (right lateral, prone, and supine). We conclude that the water-filled 8-FG esophageal catheter gives an accurate measurement of pleural pressure changes in healthy neonates.
mesh_terms: D002404:Catheterization; D004947:Esophagus / Q000502:physiology; D005652:Functional Residual Capacity; D006801:Humans; D007231:Infant, Newborn; D008170:Lung Compliance; D010994:Pleura / Q000502:physiology*; D011187:Posture; D011312:Pressure; D012129:Respiratory Function Tests / Q000379:methods