Regional brain distribution of cathepsin D activity: its inhibition in vivo following central infusion of pepstatin in the rat.
Tfhe regional distribution of cathepsin D activity was measured in 10 regiongs of rat brain. The greatest activity was found in the hypothalamo-pituitary axis and in regions surrounding the 4th ventricle. In rats injected centrally with the specific cathepsin D inhibitor, pepstatin, the protease activity was inhibited up to 90% in most brain regions.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002402:Cathepsin D; D002403:Cathepsins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D010436:Pepstatins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009842:Oligopeptides; D010436:Pepstatins; D002403:Cathepsins; D002402:Cathepsin D