Correlation of lithium effect on electroshock-induced seizure in rats with its concentration in brain and plasma.
Effects of graded doses of lithium chloride (2.5, 5.0 and 7.5 mEq/kg, i.p.) on electroshock-induced seizure threshold, recovery time and concentration of lithium (Li) ion in plasma and brain tissue of albino rats, at different post injection intervals, were investigated. A significant decrease in seizure susceptibility corresponded with high Li ion concentration at 4 to 8 hr post injection period in the rat brain tissue.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004597:Electroshock; D008094:Lithium / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D012640:Seizures / Q000503:physiopathology*; D013997:Time Factors
D008094:Lithium