Sucrose-induced behavior changes of persons with Prader-Willi syndrome.
The relationship between changed or erratic behavior of nine Prader-Willi males and their ingestion of excess kcalories from sucrose was examined. The study was a double-blind design, with objective measures of behavioral change following ingestion of either a sucrose solution or a control preparation containing starch or saccharin. On each of the 3 test days, one of the three test solutions was given, along with a standard 210 kcalorie starch-based breakfast. Blood glucose values at 0.30, 60, 120, and 180 minutes after feeding were compared to the percentage of errors made on paired-associate learning tasks (given eight times daily) and the gross-motor "movement" scores from a wrist monitor and a chair attached to an electrical counter. Results showed that out of 162 test correlations performed, only 8 were significant, exactly the number expected by chance. Possible reasons were suggested as to why no significant differences were found.
D000293:Adolescent; D000328:Adult; D001077:Aptitude Tests; D001519:Behavior / Q000187:drug effects*; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D004311:Double-Blind Method; D005502:Food / Q000009:adverse effects; D006801:Humans; D008297:Male; D011218:Prader-Willi Syndrome / Q000523:psychology*; D013395:Sucrose / Q000009:adverse effects*
D001786:Blood Glucose; D013395:Sucrose