title: [Determination of the number of GC-pairs "recognized" by actinomycin D during binding with DNA].
abstract: Experimental studies are reported on the binding of actinomycin D to various synthetic and naturally occurring DNAs. The experimental data obtained agree with a model in which the antibiotic molecule carries only one GC-specific reaction center and covers 5 base pairs upon binding to DNA. Positive cooperative effects are observed for the binding of actinomycin to poly(dG-dC)-poly (dG-dC) duplex.
mesh_terms: D001482:Base Composition; D055598:Chemical Phenomena; D002621:Chemistry; D003596:Cytosine; D004247:DNA; D003609:Dactinomycin; D006147:Guanine; D007700:Kinetics; D011089:Polydeoxyribonucleotides; D013329:Structure-Activity Relationship
chemical_list: D011089:Polydeoxyribonucleotides; D003609:Dactinomycin; C016681:poly(dG).poly(dC); D006147:Guanine; D003596:Cytosine; D004247:DNA
vernacular_title: Opredelenie chisla GC-par "uznavaemykh" aktinomitsinom D pri sviazyvanii s DNK.