Intracellular studies on the effects of systemic administration of serotonin agonists on rat facial motoneurons.
Intracellular recordings were made from facial motoneurons of anesthetized rats during systemic administration of 5-methoxy-N,-N-dimethyltryptamine (5-MeODMT) and p-chloroamphetamine (PCA), drugs which elicit the behavioral serotonin syndrome. Both drugs caused a slow depolarization, increased input resistance, and increased excitability of facial motoneurons. These changes are identical to those caused by direct microiontophoretic application of serotonin to these neurons, and probably underlie some of the components of the behavioral serotonin syndrome.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D005154:Facial Nerve / Q000187:drug effects*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D008732:Methoxydimethyltryptamines / Q000494:pharmacology; D009046:Motor Neurons / Q000187:drug effects*; D051381:Rats; D012701:Serotonin / Q000502:physiology*; D010133:p-Chloroamphetamine / Q000494:pharmacology
D008732:Methoxydimethyltryptamines; D012701:Serotonin; D010133:p-Chloroamphetamine