title: [In vitro and in vivo activity of spiramycine on Chlamydia (author's transl)].
abstract: In vitro study of spiramycine action on C. psittaci and C. trachomatis demonstrates that this antibiotic is active in a concentration similar to that found in the serum of patients who have received an injection of 4 g. However, it should be noted that even with a higher dose, few inclusions are still present. On the other hand, the action of spiramycine on mice infected with C. psittaci is highly efficient. The difference between the in vitro results and the excellent in vivo results could be explained by an important accumulation of antibiotic in the tissue.
mesh_terms: D000818:Animals; D002689:Chlamydia / Q000187:drug effects*; D002690:Chlamydia Infections / Q000188:drug therapy; D002692:Chlamydia trachomatis / Q000187:drug effects; D002691:Chlamydophila psittaci / Q000187:drug effects; D005260:Female; D006801:Humans; D007933:Leucomycins / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice
chemical_list: D007933:Leucomycins
vernacular_title: Action de la spiramycine sur les Chlamydiae.