title: Effect of sotalol on ischemic myocardial pH in the dog heart.
abstract: In dogs anesthetized with pentobarbital, the left anterior descending coronary artery (LAD) was occluded partially so that the LAD flow could be reduced to 1/2 to 1/3 the original flow (partial occlusion). Myocardial pH was recorded continuously by the use of a micro glass pH electrode inserted in the area to become ischemic by partial occlusion. Before partial occlusion, myocardial pH was 7.51--7.66. Partial occlusion reduced the pH by 0.63--0.72. Sotalol (5 mg . kg-1, i.v.) increased the pH (by 0.45) that had been reduced by partial occlusion, with a marked decrease in heart rate (about 70 beats . min-1) and a slight decrease in blood pressure (about 10 mm Hg in systolic pressure). Even when the sotalol-induced decrease in heart rate was prevented by pacing the heart, sotalol (5 mg . kg-1, i.v.) increased the pH (by 0.43) of myocardium in which LAD was partially occluded. The pH of the non-ischemic normal heart, however, was not influenced by the injection of sotalol (5 mg . kg-1, i.v.). It is concluded that the effect of sotalol to increase the pH of the ischemic heart is not related to the decrease in heart rate produced by the drug injection.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D003327:Coronary Disease / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D006339:Heart Rate; D006863:Hydrogen-Ion Concentration; D008297:Male; D013015:Sotalol / Q000494:pharmacology*
chemical_list: D013015:Sotalol