title: Tissue reaction to prosthetic obturator materials.
abstract: Two materials are currently used for construction of obturators to restore function when major maxillary defects are present: poly(methyl methacrylate) and poly(dimethyl siloxane). The advantages and disadvantages of the materials are examined and the physiologic response of the involved tissues is studied. Palatectomies were performed on primates and poly(methyl methacrylate) and poly(dimethyl siloxane) obturators were placed contacting antral and nasal mucosa. Serial biopsies and clinical evaluations revealed comparable histologic responses to both materials. Poly(dimethyl siloxane) exhibited a more favorable clinical tissue response than poly(methyl methacrylate).
mesh_terms: D000818:Animals; D001706:Biopsy; D004129:Dimethylpolysiloxanes / Q000494:pharmacology*; D008768:Methylmethacrylates / Q000494:pharmacology*; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology; D010158:Palatal Obturators / Q000009:adverse effects; D010159:Palate / Q000187:drug effects / Q000473:pathology; D010215:Papio; D012828:Silicones / Q000494:pharmacology*
chemical_list: D004129:Dimethylpolysiloxanes; D008768:Methylmethacrylates; D012828:Silicones