Biliary excretion of bisacodyl and picosulphate in man: studies in gallstone patients after biliary tract surgery.
Bisacodyl (=BIS) and picosulphate (=PICO) have been given perorally to postoperative gallstone patients, who have undergone biliary tract surgery with the insertion of an indwelling T-tube. The doses corresponded to 7.7 mg of their common free diphenol desacetylbisacodyl (=DES). The bile was sampled in hourly fraction from the external limb of the T-tube; these fractions were analysed by a modification of the HPLC method previously used to study biliary excretion in the rat. In the BIS-patients (n=8), DES in conjugated form occurred in significant concentration already in the first fractions; peak excretion values equivalent to 4-8 microgram DES/ml bile were reached in 2-5 hours. Unchanged BIS could not be detected, and the concentration levels of unconjugated DES were insignificant. The PICO-patients (n=8) on the other hand showed low DES concentrations (conjugated + free less than or equal to 0.5 microgram DES/ml) in all fractions, or low initial concentrations followed by a more or less pronounced rise in the later fractions. These results are, qualitatively, as in the rat. However, the dose fractions excreted in bile (assuming a total hepatic output of 50ml/hours) seem smaller than those to be expected from rat experiments, at least as far as BIS is concerned.
D000328:Adult; D000368:Aged; D001646:Bile / Q000378:metabolism*; D001726:Bisacodyl / Q000378:metabolism*; D002763:Cholecystectomy; D002769:Cholelithiasis / Q000378:metabolism* / Q000601:surgery; D002951:Citrates; D003408:Cresols / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D010847:Picolines / Q000378:metabolism*
D002951:Citrates; D003408:Cresols; D009942:Organometallic Compounds; D010847:Picolines; D001726:Bisacodyl; C005701:picosulfate sodium