Circannual variations in carrageenan-induced paw edema and in the anti-inflammatory effect of phenylbutazone in the rat.
Circannual variation in the edema produced by intraplantar injection of carrageenan (carr) was examined over a period of 31 months. The anti-inflammatory effect of a dose of 30 mg/kg of phenylbutazone (PHZ) was also determined over a period of 1 year. Carr-induced edema was significantly larger in spring while it was smaller in winter. PHZ induced a pronounced reduction of paw edema throughout the year except in spring when the anti-inflammatory effect of the drug could not be detected. Mechanisms responsible for these circannual variations are discussed.
D000818:Animals; D002351:Carrageenan / Q000633:toxicity*; D003345:Corticosterone / Q000097:blood; D004487:Edema / Q000139:chemically induced* / Q000188:drug therapy; D008297:Male; D010653:Phenylbutazone / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012621:Seasons
D002351:Carrageenan; D010653:Phenylbutazone; D003345:Corticosterone