Metaphase analysis of human lymphocytes treated with 4-chloromethylbiphenyl and benzyl chloride.
4CMB and BC caused mitotic inhibition in human lymphocytes at low doses (greater than 20 and greater than 10 microgram/ml respectively). At non-inhibitory concentrations, neither substance produced increases in cells with breaks or breaks per cell, although 4CMB did induce a significant increase in gaps at dose. 4CMB and BC are not chromosome mutagens in this system.
D001593:Benzyl Compounds / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology*; D002478:Cells, Cultured; D002842:Chromatids / Q000187:drug effects; D002869:Chromosome Aberrations; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology*; D008677:Metaphase / Q000187:drug effects*; D009153:Mutagens / Q000494:pharmacology*
D001593:Benzyl Compounds; D001713:Biphenyl Compounds; D009153:Mutagens; C033487:4-chloromethylbiphenyl; C021292:benzyl chloride