title: Bezafibrate: lack of effect on creatinine excretion and muscular proteins.
abstract: The effect of bezafibrate (200 mg t.i.d.) on renal and, to some degree, on muscular function was studied in nine patients with primary hyperlipoproteinemia. No signs of a reduction in creatinine excretion or an increase in muscular proteins could be found serving as a possible explanation for the slight increase in serum creatinine observed in a bezafibrate long-term study in more than 1,000 patients. Further studies are necessary for clarification.
mesh_terms: D001629:Bezafibrate; D002994:Clofibrate / Q000031:analogs & derivatives*; D002995:Clofibric Acid / Q000031:analogs & derivatives*; D003402:Creatine Kinase / Q000097:blood; D003404:Creatinine / Q000097:blood / Q000652:urine*; D005260:Female; D006801:Humans; D006951:Hyperlipoproteinemias / Q000503:physiopathology*; D000960:Hypolipidemic Agents; D007527:Isoenzymes; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009124:Muscle Proteins / Q000378:metabolism*; D009132:Muscles / Q000187:drug effects / Q000503:physiopathology*; D009212:Myoglobinuria / Q000175:diagnosis
chemical_list: D000960:Hypolipidemic Agents; D007527:Isoenzymes; D009124:Muscle Proteins; D002995:Clofibric Acid; D003404:Creatinine; D003402:Creatine Kinase; D002994:Clofibrate; D001629:Bezafibrate