[Effect of phenamine and sydnocarb on bioelectrical activity in the ventrolateral columns of the spinal cord].
It was shown in experiments on spinal rats that amphetamine (1-5 mg/kg) and sydnocarb (3.4-30 mg/kg) have an effect on bioelectrical activity in ventrolateral columns and posterior cornua of the spinal cord induced by stimulation of the sciatic nerve and intraarterial administration of bradykinin. Amphetamine (1-2 mg/kg) enhances spontaneous and evoked activities in the posterior cornua but does not change these in the ventrolateral columns. Amphetamine in a dose of 5 mg/kg reduces spontaneous and evoked activities in the formations in question. Sydnocarb (3.4-30 mg/kg) increases spontaneous and evoked activities in the posterior cornua and ventrolateral columns. Phenoxybenzamine (5 mg/kg) reduces the inhibitory action of amphetamine on the bradykinin-induced activity in the ventrolateral columns.
D000661:Amphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D004558:Electric Stimulation; D010069:Oxadiazoles / Q000494:pharmacology*; D010643:Phenoxybenzamine / Q000494:pharmacology; D051381:Rats; D012584:Sciatic Nerve / Q000502:physiology; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*; D013558:Sydnones / Q000494:pharmacology*
D010069:Oxadiazoles; D013558:Sydnones; D010643:Phenoxybenzamine; D000661:Amphetamine; D001920:Bradykinin; C009257:sidnocarb
Vliianie fenamina i sidnokarba na bioélektricheskuiu aktivnost' v ventrolateral'nykh stolbakh spinnogo mozga.