Quality control of phenylbutazone II: Analysis of phenylbutazone and its decomposition products in drugs by high-pressure liquid chromatography.
A rapid, sensitive, accurate, and reproducible procedure for the simultaneous separation and determination of phenylbutazone and three major degradation products is proposed using reversed-phase high-pressure liquid chromatography and UV detection. The method is approximately 20 times more sensitive than TLC and allows an accurate determination of degradation products without decomposition during the analysis.
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D010653:Phenylbutazone / Q000032:analysis*; D012996:Solutions / Q000032:analysis
D012996:Solutions; D010653:Phenylbutazone