Transport mechanisms of 6-diazo-5-oxo-L-norleucine in Escherichia coli K-12.
The diazo antibiotic 6 diazo-5-oxo-L-norleucine is transported into Escherichia coli using the general aromatic amino acid transport system and a specific phenylalanine transport system. Resistance to this antibiotic is the result of a decreased rate of transport of the antibiotic and also the result of a more rapid rate of efflux of the antibiotic from the cell.
D000596:Amino Acids / Q000378:metabolism; D001377:Azaserine / Q000494:pharmacology; D001391:Azo Compounds / Q000378:metabolism*; D001692:Biological Transport; D003980:Diazooxonorleucine / Q000378:metabolism* / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D005798:Genes, Bacterial; D009154:Mutation; D010649:Phenylalanine / Q000378:metabolism
D000596:Amino Acids; D001391:Azo Compounds; D003980:Diazooxonorleucine; D010649:Phenylalanine; D001377:Azaserine