Acute and chronic phencyclidine administration effects on the conversion of 3H-tryptophan to 3H-serotonin in rat forebrain.
Acute administration of phencyclidine hydrochloride (PCP) resulted in a dose-responsive decrease in the conversion of 3H-tryptophan to 3H-serotonin (3H-5-HT) in rat forebrain. Subsequent experiments measured the effect of a subthreshold dose of PCP (4 mg/kg) daily for one, seven, or four-teen days on this index of 5-HT turnover. Although single administration again had no effect at this dose, repeated administration for seven days resulted in a 37% decrease in 5-HT turnover. However, after fourteen days of administration this index was not significantly different from saline controls The possible significance of these findings are discussed in relation to reported alterations in PCP-induced behaviors observed with chronic administration.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D008297:Male; D010622:Phencyclidine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000096:biosynthesis*; D014364:Tryptophan / Q000378:metabolism*
D012701:Serotonin; D014364:Tryptophan; D010622:Phencyclidine