title: Influence of cause-of-death assignment on time-to-tumor analyses in animal carcinogenesis studies.
abstract: The importance of cause-of-death determination in an animal carcinogenesis study with respect to estimation of time-to-tumor distributions of internally occurring (occult) tumors is discussed. A nontechnical description of time-to-tumor estimation is presented. The information obtained from time-to-tumor estimation when cause-of-death designation was used is illustrated for liver tumors in female mice of the inbred strain BALB/cStCrlfC3Hf/Nctr from the ED01 study with N-2-fluorenylacetamide done at the National Center for Toxicological Research. A time-to-tumor analysis of reticulum cell sarcoma data from the same study has provided insight into some difficulties involved in routine case-by-case determination of cause of death. A more flexible system for assigning of cause of death to dead animals and cause of morbidity to moribund animals is described as a way to improve cause-of-death assignment.
mesh_terms: D015073:2-Acetylaminofluorene; D000818:Animals; D005260:Female; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000401:mortality / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000139:chemically induced / Q000401:mortality; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000401:mortality / Q000473:pathology; D011336:Probability; D012107:Research Design; D013997:Time Factors
chemical_list: D015073:2-Acetylaminofluorene