title: Regulation of natural killer activity in vivo. III. Effect of hypophysectomy and growth hormone treatment on the natural killer activity of the mouse spleen cell population.
abstract: Spleen natural killer (NK) activity against YAC tumor cells was reduced in female C57BL/6J mice hypophysectomized at 3 weeks and sacrificed 4-8 weeks later. Proportions of null cells and of target binding cells in spleens from hypophysectomized and sham operated mice were significantly different. Administration of ovine growth hormone (GH) (100 microgram/day, i.p. for 10 days) resulted in a marked recovery of NK activity in hypophysectomized mice. NK activity by spleen cells from hypophysectomized or sham operated mice (with or without GH treatment) was mediated by non-T, non-B lymphocytes.
mesh_terms: D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D003165:Complement System Proteins; D003602:Cytotoxicity, Immunologic; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology*; D007016:Hypophysectomy; D051379:Mice; D008810:Mice, Inbred C57BL; D011817:Rabbits; D012756:Sheep; D013154:Spleen / Q000276:immunology*
chemical_list: D000961:Antilymphocyte Serum; D013006:Growth Hormone; D003165:Complement System Proteins