title: Retrograde influence of surgical and chemical flocculectomy upon dorsal cap neurons of the inferior olive.
abstract: Retrograde influence of cerebellar cortical lesions upon neurons of the inferior olive was examined in albino rabbits after survival for 2 weeks. Ablation of the flocculus on one side induced a cell loss by 41% accompanied by a size reduction of as much as 27% in the contralateral dorsal cap, the source of climbing fiber afferents to the flocculus. By contrast, after destruction of flocculus Purkinje cells with local injections of 0.1% kainic acid-saline solution, there was no retrograde cell loss in the dorsal cap. However, a slight reduction in cell size (less than 10%) was noted.
mesh_terms: D000818:Animals; D002525:Cerebellar Cortex / Q000187:drug effects / Q000502:physiology*; D007608:Kainic Acid / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009847:Olivary Nucleus / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D011759:Pyrrolidines / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D011759:Pyrrolidines; D007608:Kainic Acid