title: Prevalence of severe arteriosclerosis obliterans in patients with diabetes mellitus. Relation to smoking and form of therapy.
abstract: Noninvasive methods were used to determine the prevalence and severity of arteriosclerosis obliterans associated with diabetes in 674 subjects including 153 recruited as controls. A resting ankle systolic blood pressure that was less than 90% of the arm pressure indicated severe arteriosclerosis obliterans. Of the 71 subjects with severe disease, 64 (90%) had a history of smoking, which is significantly greater than the 60% overall smoking rate (p less than 0.001). In non-insulin-dependent diabetic smokers, the diet-treated subjects had 2.5 times the prevalence of severe arteriosclerosis obliterans as those treated with insulin (p = 0.01); the sulfonylurea-treated subjects had twice the prevalence of severe disease as those treated with insulin (p = 0.015).
mesh_terms: D000328:Adult; D000368:Aged; D001162:Arteriosclerosis Obliterans / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D001794:Blood Pressure; D003925:Diabetic Angiopathies / Q000150:complications* / Q000178:diet therapy / Q000188:drug therapy; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007866:Leg / Q000098:blood supply; D008875:Middle Aged; D010629:Phenformin / Q000627:therapeutic use; D012907:Smoking; D014861:Washington
chemical_list: D007328:Insulin; D010629:Phenformin