Effect of naloxone on met-enkephalin-induced gastric acid secretion and serum gastrin in man.
It has previously been demonstrated that met-enkephalin, and endogenous opiate, stimulates gastric acid secretion in man, while naloxone inhibits meal-stimulated acid secretion. In seven healthy subjects the opiate receptor antagonist naloxone was infused in a dose of 10 microgram/kg/h during stimulation of gastric acid secretion with pentagastrin 100 ng/kg/h and met-enkephalin 0.1 microgram/kg/h. Naloxone had no effect on pentagastrin-induced acid secretion, whereas met-enkephalin-induced acid secretion was completely abolished in both studies without affecting serum gastrin levels, suggesting that the acid inhibitory effect of naloxone is specifically directed towards met-enkephalin-induced acid secretion. The results support the assumption that met-enkephalin participates in the physiological stimulation of gastric acid secretion.
D000328:Adult; D004723:Endorphins / Q000037:antagonists & inhibitors*; D004744:Enkephalin, Methionine; D004745:Enkephalins / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000494:pharmacology*; D010418:Pentagastrin / Q000494:pharmacology
D004723:Endorphins; D004745:Enkephalins; D005755:Gastrins; D009270:Naloxone; D004744:Enkephalin, Methionine; D010418:Pentagastrin