Synergism of (15 S)-15-methyl-prostaglandin E1 with either azathioprine or prednisolone on the survival of heart allografts in rats.
Survival time of Brown Norway (BN) to Wistar (WR) heart allografts without immunosuppressive treatment is 7-10 days. Azathioprine or prednisolone do not improve the graft survival in this model significantly. However, treatment with (15 S)-15-methyl-PGE1 (15-M-PGE1), a synthetic long acting prostaglandin, which can be administered orally, in combination with either azathioprine or prednisolone increased the survival of the allogeneic heart grafts substantially. A synergistic inhibitory effect of 15-M-PGE1 and prednisolone was also noted in carrageenan induced granulomatous inflammation.
D000527:Alprostadil / Q000031:analogs & derivatives*; D000818:Animals; D001379:Azathioprine / Q000494:pharmacology*; D004357:Drug Synergism; D006085:Graft Survival / Q000187:drug effects*; D016027:Heart Transplantation; D008297:Male; D011239:Prednisolone / Q000494:pharmacology*; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D011459:Prostaglandins E, Synthetic; C025170:15(S)-15-methylprostaglandin E1; D011239:Prednisolone; D000527:Alprostadil; D001379:Azathioprine