Lymphomas and leukemias in the relatives of patients with mycosis fungoides.
Of 526 consecutive patients with cutaneous T-cell lymphomas, 21 had first-degree relatives with lymphoproliferative or hematopoietic malignancies. Twenty-nine such tumors occurred in the 21 kindreds. Hodgkin's disease accounted for one-third of this total, with various leukemias (11 cases), non-Hodgkin's lymphoma (five cases), and multiple myeloma (three cases) comprising the remainder. These data suggest that genetically-determined immunoregulatory abnormalities may represent a shared pathway of oncogenesis in diverse lymphoproliferative and hematopoietic malignancies.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D004812:Epidemiologic Methods; D005260:Female; D006689:Hodgkin Disease / Q000235:genetics / Q000473:pathology; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000473:pathology; D008223:Lymphoma / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000235:genetics* / Q000473:pathology; D010375:Pedigree; D044469:Racial Groups; D012737:Sex Factors; D014481:United States