Bio-inorganic regulation of pathways of carbohydrate and lipid metabolism. II. The effect of iron-deficiency on the profile of enzymes in the developing rat adrenal gland.
The effect of iron-deficiency anaemia and iron supplementation on the enzyme profile and conversion of specifically labelled glucose to 14CO2 and 14C-lipid was measured in rat adrenal glands. Enzymes involved in lipogenesis were severely depressed in iron deficiency, addition of Fe2+ to the diet resulted in increased activity of fatty acid synthetase (+75%), NADP isocitrate dehydrogenase (+466%), glucose-6-phosphate dehydrogenase (+27%) and malic enzyme (+46%). Parallel increases occurred in the flux of glucose into lipid. The effects of iron-deficiency anaemia on adrenal and thyroid function in relation to developmental processes are discussed.
D000311:Adrenal Glands / Q000201:enzymology*; D000747:Anemia, Hypochromic / Q000201:enzymology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D050260:Carbohydrate Metabolism; D004041:Dietary Fats / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D009249:NADP / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D004041:Dietary Fats; D009249:NADP; D005947:Glucose