Cadmium inhibition of in vitro hepatic oxidative drug metabolism in the rat: comparison between ionic cadmium and cadmium-thionein.
The effectiveness of cadmium added in vitro in inhibiting the microsomal oxidative metabolism of ethylmorphine or aniline in rat hepatic microsomes was markedly decreased if the metal was added as cadmium-thionein when compared to ionic cadmium. These data are consistent with the hypothesis that cadmium thionein is less active biologically than ionic cadmium.
D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D005037:Ethylmorphine-N-Demethylase / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D008667:Metalloproteins / Q000494:pharmacology*; D008668:Metallothionein / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D008667:Metalloproteins; D004364:Pharmaceutical Preparations; C004203:cadmium-binding protein; D002104:Cadmium; D008668:Metallothionein; D000815:Aniline Hydroxylase; D005037:Ethylmorphine-N-Demethylase