Teratological effects of western equine encephalitis virus on the fetal nervous system of Macaca mulatta.
Fetal rhesus monkeys were inoculated intracerebrally with an attenuated strain of western equine encephalitis virus. All animals developed microcephaly. Twelve of sixteen monkeys developed ex vacuo hydrocephalus. All virus inoculated fetuses developed WEE virus antibody. Virus could not be recovered at the time of delivery. Monkeys with the highest WEE antibody titers showed the greatest degree of hydrocephalus.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001921:Brain / Q000002:abnormalities*; D002552:Cerebral Ventricles / Q000002:abnormalities; D004667:Encephalitis Virus, Western Equine / Q000276:immunology; D004683:Encephalomyelitis, Equine / Q000150:complications* / Q000276:immunology; D006849:Hydrocephalus / Q000209:etiology; D008253:Macaca mulatta
D000914:Antibodies, Viral