Blood pressure changes and cardiovascular lesions found in rats given T-2 toxin, a trichothecene secondary metabolite of certain Fusarium microfungi.
White weanling rats were given intragastrically 4 doses of T-2 toxin (3 alpha-hydroxy-4 beta-1,5-diacetoxy-8 alpha-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene) a secondary metabolite of certain Fusarium species, 6 out of 9 treated rats developed increased blood pressure; these animals showed microscopically severe cardiovascular abnormalities. Occasional contamination of foodstuffs wh Fusarium may contribute to hypertension and cardiovascular lesions in animals and man.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002319:Cardiovascular System / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012717:Sesquiterpenes / Q000633:toxicity*; D013605:T-2 Toxin / Q000633:toxicity*
D012717:Sesquiterpenes; D013605:T-2 Toxin