Effects of blood glucose levels on [14C]2-deoxyglucose uptake in rat brain tissue.
Brain uptake of [14C]2-deoxyglucose (2-DG) was measured in fasted and fed rats. Enhanced uptake was observed in fasted rats. A statistically significant negative correlation was found between blood glucose levels and 2-DG uptake. The use of fasted, hypoglycemic animals and lower doses of 2-DG in 2-DG research is suggested in order to economize, to reduce variability, and to reduce attendant exposure to toxicity and radiation.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D001921:Brain / Q000378:metabolism*; D002250:Carbon Radioisotopes; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D004435:Eating; D005215:Fasting; D005260:Female; D008297:Male; D051381:Rats / Q000502:physiology*; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D002250:Carbon Radioisotopes; D003837:Deoxy Sugars; D003847:Deoxyglucose