title: [Effect of anabasine hydrochloride on embryogenesis in white rats and rabbits].
abstract: The author reports the results of testing the embryotropic activity of anabasineee hydrochloride in doses of 15, 5, and 3 mg/kg. It was found that oral administration of the drug to pregnant rats in doses exceeding 10-fold (5 mg/kg) and 20-fold (10 mg/kg) the therapeutic ones produced no adverse effect on the fetus. In a dose of 15 mg/kg the drug exerted a moderate embryotoxic action. Multiple oral administration of anabasin hydrochloride to rats in a dose of 3 mg/kg produced no embryotoxic effect. It is concluded that anabasin hydrochloride has no teratogenic properties.
mesh_terms: D000691:Anabasine / Q000009:adverse effects*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005865:Gestational Age; D010880:Piperidines / Q000009:adverse effects*; D011247:Pregnancy; D011817:Rabbits; D051381:Rats
chemical_list: D010880:Piperidines; D000691:Anabasine
vernacular_title: Vliianie anabazina gidrokhlorida na émbriogenez  belykh krys i krolikov.