Intracoronary infusion of small doses of nifedipine lowers regional myocardial O2-consumption without altering regional myocardial function.
Intracoronary infusion of low doses (0.1-0.3 microgram X kg-1) of nifedipine caused dose-dependent decreases in regional myocardial O2-consumption, without significant changes in any of its major global hemodynamic determinants: heart rate, left ventricular systolic and end-diastolic pressure and maxLVdP/dt. Furthermore, regional myocardial function was unaltered. It is suggested that nifedipine decreased myocardial O2-consumption by a direct effect on myocardial metabolism. Some of the possible mechanisms involved are discussed.
D000818:Animals; D003331:Coronary Vessels; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000502:physiology; D007261:Infusions, Intra-Arterial; D007263:Infusions, Parenteral; D009206:Myocardium / Q000378:metabolism*; D009543:Nifedipine / Q000008:administration & dosage* / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects*; D011725:Pyridines / Q000008:administration & dosage*; D013552:Swine
D011725:Pyridines; D009543:Nifedipine