title: [Serotonin independently stimulates fibroblast adhesion and multiplication in culture].
abstract: The influence of serotonin on the adhesion and growth processes in primary cultures of murine and human embryo fibroblasts and L-cells was studied separately. At the moment of seeding, serotonin shortened the time of adhesion of glass surface of these from approximately 4 to 1 or 2 hours and stimulated incorporation of tritiated thymidine and cell multiplication when  introduced in 2- or 6-hour cultures. Adhesion- and growth- stimulatory activities were blocked by serotonin antagonists - cyproheptadine and tipindole, demonstrating that the specific binding of bioamine with cell receptors is essential in both the cases.
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects*; D006801:Humans; D007739:L Cells / Q000187:drug effects; D051379:Mice; D012701:Serotonin / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013997:Time Factors
chemical_list: D012701:Serotonin
vernacular_title: Serotonin nezavisimo stimuliruet adgeziiu i razmnozhenie fibroblastov v kul'ture.