The effect of 4CMB on germ cells of the mouse.
The effect of 4CMB on meiosis in the mouse was studied using both male and female test systems. Females were superovulated and treated with 4CMB at metaphase I and oocytes sampled at metaphase II. Similarly with males, chromosome analysis was made at metaphase II for spermatocytes treated at metaphase I. No increase in the frequency of structural of numerical chromosome abnormalities was noted for treated mice as compared to controls.
D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology*; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D002869:Chromosome Aberrations; D005260:Female; D006064:Gonadotropins, Equine / Q000494:pharmacology; D008297:Male; D008540:Meiosis / Q000187:drug effects*; D008677:Metaphase / Q000187:drug effects; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D009865:Oocytes / Q000187:drug effects*; D010060:Ovulation / Q000187:drug effects; D010063:Ovum / Q000187:drug effects*; D013090:Spermatocytes / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects*
D001713:Biphenyl Compounds; D006063:Chorionic Gonadotropin; D006064:Gonadotropins, Equine; D009153:Mutagens; C033487:4-chloromethylbiphenyl