A new antibiotic echinosporin (XK-213) - producing organism, isolation and characterization.
Streptomyces echinosporus MK-213 produces a noval antibiotic echinosporin (XK-213). Isolation of echinosporin was performed by absorption on activated carbon under acidic conditions and then eluted by aqueous acetone. The compound crystallized from methanol is a water soluble white solid composed of C10H9NO5. Echinosporin exhibits weak antibacterial activities against Gram-positive and -negative microorganisms and its shows antitumor activity.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D007783:Lactones / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D007928:Lethal Dose 50; D051379:Mice; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D007783:Lactones; C034567:echinosporin