[Role of lipid peroxidation in the pathogenesis of ischemic injury and the antioxidant protection of the heart].
It has been shown that an important link of the heart ischaemic damage in the infarction is the so-called lipid triad supervening in the lipid bilayer of cardiomyocyte membranes. This triad consists in the activation of the lipid peroxidation (LPO), phospholipase activation, and the detergent effect of high concentrations of fatty acids, that results in an increase of the membrane permeability for calcium and plays an important role in the transition from the reversible ischaemic damage to the irreversible. The LPO activation established by the authors in the myocardial infarction in the ischaemic and non-ischaemic zones seems to be the link triggering the lipid triad. Administration of the synthetic LPO inhibitors, antioxidants 2.6 - ditretbutyl - 4 - methyl phenol, or OP-6 significantly decreased the ischaemic necrosis area, fermentemia and disturbances of the cardiac contractility in experimental infarction.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D003327:Coronary Disease / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D000860:Hypoxia / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D008051:Lipid Bilayers / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism*; D009200:Myocardial Contraction / Q000187:drug effects; D009203:Myocardial Infarction / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D009336:Necrosis; D010084:Oxidation-Reduction
D000975:Antioxidants; D008051:Lipid Bilayers; D008054:Lipid Peroxides
Rol' perekisnogo okisleniia lipidov v patogeneze ishemicheskogo povrezhdeniia i antioksidantnaia zashchita serdtsa.