Experimental model for liver metastasis formation using Lewis lung tumor.
A new experimental model is introduced for liver metastases using intrasplenically injected Lewis lung tumor cells. The appearance of liver metastases was studied in the presence and after the removal of primary tumor. The tumorous foci in the liver proved to be natural metastases and increased in number blocking the activity of the Kupffer cells by carragheenan. This model provides a useful tool to study different aspects of liver metastases.
D000818:Animals; D002351:Carrageenan / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D007728:Kupffer Cells / Q000187:drug effects; D008113:Liver Neoplasms / Q000556:secondary*; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology; D009929:Organ Size; D013154:Spleen / Q000473:pathology; D013156:Splenectomy
D002351:Carrageenan