title: Nimesulide in the short-term treatment of osteoarthrosis: a pilot study for assessing the minimal effective dose.
abstract: Eleven patients suffering from osteoarthritis of the cervical spine were admitted to a pilot study aimed at establishing the effective dose and the tolerability of Nimesulide. The patients received a basic treatment of Nimesulide 100 mg/day, increasable up to 300 mg/day, in conformity with the patient's need. The treatment over a period of 15 days showed that Nimesulide 200 mg/day has good anti-inflammatory and analgesic properties. Several critical parameters were significantly improved. The incidence of usually mild side-effects was very low.
mesh_terms: D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D010865:Pilot Projects; D013449:Sulfonamides / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D013449:Sulfonamides; C012655:nimesulide