Characterization of glycosaminoglycans associated with Rauscher murine leukemia virions.
Host-derived sulfated components that copurify and are physically associated with the envelope of Rauscher murine leukemia virions grown in JLS-V9 cells were characterized by digestion with chondroitinase ABC and chondroitinase AC II, as well as nitrous acid degradation. A dermatan-sulfate-chondroitin-sulfate copolymer and heparin or heparan sulfate wee shown to be associated with the virions. Competitive binding studies indicated a specificity of the virions for association with heparan sulfate. The physiological importance of the association is discussed.
D000818:Animals; D006025:Glycosaminoglycans / Q000032:analysis*; D006497:Heparan Sulfate / Q000032:analysis; D051379:Mice; D011925:Rauscher Virus / Q000032:analysis*; D014771:Virion / Q000032:analysis
D006025:Glycosaminoglycans; D006497:Heparan Sulfate