Carcinogenicity of vinylethylnitrosamine in Syrian golden hamsters.
Syrian golden hamsters received weekly s.c. doses of 5.0, 2.5, 1.25 or 0.63 mg/kg b.w. vinylethylnitrosamine (VEN). As dose levels increased, average survival time decreased, tumor multiplicity increased as did the total tumor rate which was between 50% and 100%. The main target of VEN effect was the respiratory tract where a positive dose-response relationship was established for neoplastic growth.
D000818:Animals; D002273:Carcinogens; D006224:Cricetinae; D004067:Digestive System Neoplasms / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D008647:Mesocricetus; D009602:Nitrosamines / Q000633:toxicity*; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced* / Q000401:mortality / Q000473:pathology
D002273:Carcinogens; D009602:Nitrosamines; C032754:vinylethylnitrosamine