The effects of phenoxybenzamine on the aortic pressure-diameter relationship in dogs.
The normalized diameter (D/D13.3 where D13.3 equals D at 13.3 kPa under control conditions) was measured at selected pressure levels under different hemodynamic conditions. Hemorrhage caused the normalized diameter to decrease (-3.3%) when compared to control values at a given pressure. Volume expansion and alpha-blockade with phenoxybenzamine caused D/D13.3 to increase (+3.3% and +8.5% respectively).
D000818:Animals; D001011:Aorta / Q000033:anatomy & histology* / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D001810:Blood Volume; D004285:Dogs; D006470:Hemorrhage / Q000473:pathology; D008297:Male; D010643:Phenoxybenzamine / Q000494:pharmacology*
D010643:Phenoxybenzamine