title: Coarctation of the aorta in infants and children: 25 years of experience.
abstract: Repair of coarctation of the aorta was performed in 334 patients ranging from less than a year to 16 years of age at Children's Hospital of Pittsburgh from 1953 to 1977. Resection and end-to-end anastomosis were performed in 310, interposition grafts in 7, and other procedures in 17. There were 41 operative deaths among the 95 infants less than 1 year old (43% mortality); all of these infants had associated cardiac anomalies. Only 1 operative death occurred in patients older than a year (0.4% mortality). No hospital deaths occurred in patients with isolated coarctation of the aorta. Eleven late deaths were due to associated anomalies (7) and unrelated or unknown causes (4). Postoperatively, hemorrhage occurred in 7, paradoxical or persistent hypertension in 128, postcoarctectomy syndrome in 32, neurological problems in 14, pulmonary complications in 53, and infections in 12 patients. Restenosis occurred in 26 patients (8%); only 10 have required reoperation. Residual hypertension was present in 28 of 264 patients (11%). Mortality from coarctation resection remains high in infants, but is minimal in children older than 1 year. Based on minimizing the risk of restenosis and residual hypertension, elective repair of coarctation is recommended when the patient is about 6 years of age.
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001017:Aortic Coarctation / Q000601:surgery*; D001424:Bacterial Infections / Q000150:complications; D002648:Child; D002675:Child, Preschool; D005260:Female; D006470:Hemorrhage / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000150:complications; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009026:Mortality; D010243:Paralysis / Q000150:complications; D011183:Postoperative Complications; D012131:Respiratory Insufficiency / Q000150:complications