title: Maternally derived immunity to canine parvovirus infection: transfer, decline, and interference with vaccination.
abstract: Antibody to canine parvovirus (CPV) was transferred from an immune bitch to her pups through the placenta and colostrum. Colostral transfer accounted for approximately 90% of the maternally-derived CPV antibody. After suckling, pups and hemagglutination-inhibition titers that averaged 50% of their dam's titer. Maternally derived CPV antibody declined with a half-life of 9.7 days. Pups with hemagglutination-inhibition titers greater than or equal to 1:80 were immune to oronasal challenge with virulent CPV, but any detectable hemagglutination-inhibition antibody (titer greater than or equal to 1:10) interfered with active immunization by modified-liver feline panleukopenia virus, inactivated feline panleukopenia virus, or inactivated CPV vaccines.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D003126:Colostrum / Q000276:immunology; D004283:Dog Diseases / Q000276:immunology* / Q000517:prevention & control; D004285:Dogs / Q000276:immunology*; D005260:Female; D007112:Immunity, Maternally-Acquired; D008431:Maternal-Fetal Exchange; D010321:Parvoviridae / Q000276:immunology*; D011247:Pregnancy; D014765:Viral Vaccines / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines