title: Altered hydroxydesipramine concentrations in elderly depressed patients.
abstract: Recent reports demonstrate that hydroxy metabolites of desipramine (DMI) have pharmacologic activity and do not just produce side effects. In patients treated with DMI, we determined the ratio of 2-hydroxydesipramine (2-OH-DMI) to drug at steady state. The ratios in the elderly patients were higher than in younger patients, and whereas plasma levels of 2-OH-DMI increased with age, urinary clearances decreased. The known decrease in glomerular filtration with age may explain the selective increase of 2-OH-DMI concentration in the elderly.
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D003863:Depression / Q000188:drug therapy; D003891:Desipramine / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008297:Male; D008875:Middle Aged
chemical_list: D003891:Desipramine; C028653:2-hydroxydesipramine