Ethanol-induced increase in procainamide acetylation in man.
1 The effect of ethanol on procainamide pharmacokinetics was studied in humans by two different experimental designs. In one, ethanol was given 1.5 h after taking the drug followed by hourly drinks, while in the other ethanol was given 2 h before and subsequently after taking the drug. 2 In both studies, ethanol caused a significant reduction of T1/2 and a significant increase in total clearance of procainamide, while the apparent volume of distribution of procainamide, as well as the renal clearance of both procainamide and N-acetylprocainamide were unaffected by ethanol treatment. 3 Ethanol treatment increased the percentage of N-acetylprocainamide measured in blood and urine and the ratio of AUCNAPA/AUCPA significantly. 4 The T1/2 and total clearance of procainamide was significantly different in slow and rapid acetylators.
D000085:Acetates / Q000097:blood; D000107:Acetylation; D000328:Adult; D001682:Biological Availability; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D011342:Procainamide / Q000378:metabolism*
D000085:Acetates; D000431:Ethanol; D011342:Procainamide