Chronic phencyclidine, like amphetamine, produces a decrease in [3H]spiroperidol binding in rat striatum.
Rats were treated with d-amphetamine sulfate (5 and 10 mg/kg i.p.) and phencyclidine (PCP) (5 mg/kg i.p.) twice per day. After 21 days, [3H]spiroperidol binding in striatum was reduced by all treatments; receptor number (Bmax) and not affinity (KD) was affected. These results suggest that the psychotic effect of PCP may, like those of amphetamine, involve changes in dopamine receptors.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D002090:Butyrophenones / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D003864:Depression, Chemical; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013134:Spiperone / Q000378:metabolism*
D002090:Butyrophenones; D013134:Spiperone; D000661:Amphetamine; D010622:Phencyclidine