title: Pulmonary toxicity following gastrointestinal ingestion of kerosene.
abstract: The continuous controversy concerning the treatment for acute hydrocarbon ingestions led to a study of the pulmonary effects of kerosene absorption from the gastrointestinal tract in dogs. Gastrostomies and cervical esophageal transections with a proximal esophageal fistula were performed on 11 dogs under general anesthesia. Following a return of normal bowel function each animal was given 20 cc/kg of a commercial-grade kerosene by gastrostomy tube. The dogs were randomly divided into two groups for necropsy at 24 and at 72 hours, and each dog had chest radiographs prior to instillation of the kerosene and at 6, 24, 48, and 72 hours, depending on their group. The dogs were given an overdose of barbiturate for euthanasia. Tissue was randomly selected from the lungs and examined using standard microscopic and histologic techniques. No clinical complications were observed in any of the animals following the kerosene instillation. No radiologic or histologic evidence of pulmonary changes due to kerosene was found. The lack of pulmonary pathologic changes following kerosene ingestion in dogs protected from aspiration suggests that the treatment for kerosene poisoning should be confined to supportive measures. Induction of emesis is contraindicated in the management of hydrocarbon ingestion.
mesh_terms: D000818:Animals; D004285:Dogs; D004639:Emetics / Q000627:therapeutic use; D005751:Gastric Lavage; D001239:Inhalation; D007408:Intestinal Absorption; D007648:Kerosene / Q000506:poisoning*; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology*; D008171:Lung Diseases / Q000139:chemically induced; D008954:Models, Biological; D010578:Petroleum / Q000506:poisoning*; D011859:Radiography
chemical_list: D004639:Emetics; D007648:Kerosene; D010578:Petroleum