Quinacrine-induced psychiatric disturbances.
We have described three patients who illustrate the broad clinical spectrum of quinacrine-associated neuropsychiatric disturbances. The toxic manifestations range from subtle changes of restlessness, insomnia, hyperirritability to frank psychosis and seizures. These symptoms may follow only a few doses of the drug, or they may occur well after the drug has been discontinued. Our patients reemphasize the importance of recognizing the variability of quinacrine-induced toxic reactions.
D000328:Adult; D005260:Female; D005873:Giardiasis / Q000188:drug therapy; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy; D008297:Male; D011605:Psychoses, Substance-Induced / Q000175:diagnosis / Q000209:etiology*; D011796:Quinacrine / Q000009:adverse effects* / Q000627:therapeutic use
D011796:Quinacrine