title: Use of oral metronidazole HCl (Flagyl) for posturethritis syndrome.
abstract: Six men with nongonococcal urethritis (NGU) who remained symptomatic after specific therapy with different antibiotic regimens were empirically treated with either of two regimens of oral metronidazole: 500 mg., three times a day for ten days, or 2.5 Gm. (10 x 250 mg.) orally in one dose. All patients had pretreatment seminal fluid cultures. No significant pathogen could be isolated. Side effects included generalized weakness, gastrointestinal symptoms, and a characteristic metallic taste. All patients became asymptomatic after therapy. The single-dose therapy seemed to be more effective in persistent cases. Since metronidazole is active only against anaerobic bacteria, it is postulated that currently unidentified anaerobic bacteria may play a role in at least some cases of posturethritis syndrome.
mesh_terms: D000328:Adult; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D008875:Middle Aged; D012008:Recurrence; D014526:Urethritis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D008795:Metronidazole