Adverse reactions to tetanus toxoid.
A retrospective review of 740 charts of patients with a history of adverse reaction to tetanus toxoid immunization was undertaken. The most common reactions, by history, were local edema and tenderness (33%), fever (15%), and anaphylactoid response (33%). Three patients who had a vesicular eruption at the immunization site were found to have delayed hypersensitivity to mercury. Thirty percent of the patients had received tetanus toxoid within one year and 55% within five years of evaluation. Reactive responses to immediate skin tests were exceedingly rare (less than 1%). None of the challenge patients suffered an adverse reaction.
D000293:Adolescent; D000328:Adult; D000707:Anaphylaxis / Q000209:etiology*; D004168:Diphtheria Toxoid / Q000009:adverse effects; D004890:Erythema / Q000209:etiology; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D012189:Retrospective Studies; D012882:Skin Tests; D013742:Tetanus / Q000517:prevention & control; D013743:Tetanus Antitoxin / Q000032:analysis; D013745:Tetanus Toxoid / Q000009:adverse effects*
D004168:Diphtheria Toxoid; D013743:Tetanus Antitoxin; D013745:Tetanus Toxoid