[Mechanisms of the development of strophanthin hypersensitivity in experimental myocardial infarct and its pharmacological correction].
The tolerance changes to strophanthin in cats were studied during 7 days after occlusion of the coronary artery along with the determination of the electrolyte concentration in different areas of the myocardium. It is shown that the acute disorder of the coronary circulation produces during 2 days considerable decrease of tolerance to the cardiotoxic action of strophanthin, which correlates with the electrolyte imbalance in the ischaemic and the adjacent areas of myocardium. Pharmacological analysis with the use of medicinal agents, possessing different properties established that the hypersensitivity to strophanthin in experimental myocardial infarction is an integral result of the influence of a number of factors, which when taken into account permit selection of rational medicinal correction of this phenomenon in different periods of acute myocardial ischaemia.
D000818:Animals; D002415:Cats; D004342:Drug Hypersensitivity / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D004361:Drug Tolerance; D004573:Electrolytes / Q000378:metabolism; D005260:Female; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D009206:Myocardium / Q000378:metabolism; D013328:Strophanthins / Q000276:immunology*; D013997:Time Factors
D004573:Electrolytes; D013328:Strophanthins
Mekhanizmy razvitiia giperchuvstvitel'nosti k strofantinu pri éksperimental'nom infarkte miokarda i ee farmakologicheskaia korrektsiia.