Natural history of breast cancer.
Retrospective analysis was made of 3,918 cases of breast cancer seen during 1954-1964. Median survival was 4.5 years and 30% of patients survived through a 10-year period. For stages I, II, and III patients, the mortality increased during 1-4 years after diagnosis and then slowly declined. Beyond 15 years, stage III patients assumed the same mortality (5%) as those with lesser disease; 58% excess of deaths from all causes after 15-20 years showed that breast cancer was not curable within 20 years but ultimately, taking account of clinical status, 51% of 5-year survivors with stages I-III disease are cured.
D001943:Breast Neoplasms / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008408:Mastectomy; D008593:Menopause; D008598:Menstruation; D009367:Neoplasm Staging