Immunopotentation of the IgE antibody response by 13-cis-retinoic acid.
Pretreatment of Balb/c mice per os with 13-cis retinoic acid (13-cRA) in gelatin beadlets potentiated the production of a secondary IgE response to ovalbumin (OA) without a detectable primary response. Dose response experiments indicated that a single feeding of the lower doses (0.3 and 1.5 mg/dose) on day -1 potentiated the production of a low IgE response, whereas pretreatment with the higher concentrations of 13-cRA (3.0 and 6.0 mg/dose) potentiated a higher, sustained response. Pretreatment with 4 doses of 13-cRA on a weekly basis prior to immunization potentiated the production of high sustained secondary titers (titer 360-480) regardless of the concentration of 13-cRA used. These results suggest that 13-cRA has both an immunopotentiating effect and a suppressing effect.
D000276:Adjuvants, Immunologic; D000818:Animals; D005260:Female; D007117:Immunization, Secondary; D007073:Immunoglobulin E / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D014212:Tretinoin / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D007073:Immunoglobulin E; D014212:Tretinoin; D010047:Ovalbumin