title: Chronic and reproduction studies in rats exposed to gasifier ash leachates.
abstract: Ash from the coal gasification process contains a broad spectrum of elements which through leaching (gasifier ash leachates) may enter into the environment. The health effect of such leachates i.e. complex mixtures of inorganic elements is insufficiently known. We investigated the effect of gasifier ash leachates in a chronic-(9-month) and in a three-generation reproduction study. The leachates were prepared weekly by water extraction of ash from a Lurgi coal gasification plant in Yugoslavia, and given to experimental animals instead of drinking water. In the chronic experiment exposed animals showed no changes in mortality rate, haematological findings, concentration of Fe, Zn, Mn in kidneys, liver, testicles and femur, as well as in femur composition and morphometry, gross pathology and organ histology. In the reproduction study the number of pregnancies, weight and number of newborns, and concentration of Fe, Zn, Mn in carcasses of sucklings were the same in control and experimental animals.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003031:Coal; D005260:Female; D008297:Male; D011210:Power Plants; D011247:Pregnancy; D011507:Proteinuria; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D014873:Water Pollutants / Q000009:adverse effects*; D014874:Water Pollutants, Chemical / Q000009:adverse effects*
chemical_list: D003031:Coal; D014873:Water Pollutants; D014874:Water Pollutants, Chemical