[Variations in vasopressin (ADH)-levels during NLA combined with epidural fentanyl-analgesia (author's transl)].
10 patients scheduled for thoracic, abdominal or vascular surgery received anaesthesia as a combination of neuroleptanalgesia plus epidural opiate-analgesia. Antidiuretic hormone levels (ADH), serum-electrolytes (Na+, K+) and plasma osmolality have been investigated preoperatively (twice), intraoperatively (six times), during the first postoperative day (three times) and for five days postoperatively (once a day). There was a significant increase in ADH in all patients intra- and postoperatively, whereas serum-electrolytes and plasma-osmolality stayed within normal range. Maximum ADH-values were measured during the intraoperative period, postoperatively ADH-levels reached the normal range after 5 days. This increase in plasma-ADH-levels was not accompanied by typical haemodynamic changes. From the aspect of metabolic endocrine response to surgery, our results indicate no advantage of the combination of neurolept-analgesia plus epidural opiate-analgesia for the intraoperative period.
D000368:Aged; D000767:Anesthesia, Epidural; D005283:Fentanyl; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D009458:Neuroleptanalgesia; D009994:Osmolar Concentration; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D014667:Vasopressins / Q000097:blood*
D014667:Vasopressins; D012964:Sodium; D011188:Potassium; D005283:Fentanyl
Plasma-ADH-Spiegel unter kombinierter Neurolept-Analgesie/Peridurale Opiat-Analgesie.