Cardiac electrophysiologic effect of indomethacin.
The anti-inflammatory agent indomethacin has been shown to antagonize calcium in smooth muscle. This study looked at indomethacin's effect on ventricular muscle and conduction tissue. Indomethacin shortened the duration of the action potential plateau in the tissue studied. This was probably a result of its interference with transmembrane calcium movement.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004285:Dogs; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D010210:Papillary Muscles / Q000187:drug effects; D011690:Purkinje Fibers / Q000187:drug effects
D007213:Indomethacin