An autoradiographic demonstration of prazosin binding to arterial vessels in the rat.
Prazosin is believed to have an antihypertensive action due to a selective blockade of alpha-adrenoceptors on vascular smooth muscle. Using an in vitro autoradiographic technique specific binding of [3H]prazosin to the abdominal aorta and renal artery in the rat has been shown. The binding of [3H]prazosin to arterial vessels may provide some evidence for the site where prazosin exerts its antihypertensive action.
D000818:Animals; D001011:Aorta / Q000378:metabolism; D001158:Arteries / Q000378:metabolism*; D001345:Autoradiography; D066298:In Vitro Techniques; D008297:Male; D011224:Prazosin / Q000378:metabolism*; D011799:Quinazolines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012077:Renal Artery / Q000378:metabolism
D011799:Quinazolines; D011224:Prazosin