Deuterated methoxyflurane anesthesia and renal function in Fischer 344 rats.
Inorganic fluoride (F-) production and renal function were assessed in six groups of Fischer 344 rats administered either methoxyflurane (MOF) or deuterated methoxyflurane (d4-MOF). One untreated and one phenobarbital (PB)-treated group were exposed for two hours to either air, 0.5 per cent (V/v) MOF, or 0.5 per cent (v/v) d4-MOF. Serum and urinary F- and serum urea nitrogen and creatinine were measured. Urine volume and urinary F- excretion were only slightly greater among MOF than among d4-MOF exposed animals. Pretreatment with PB, however, greatly enhanced F- production in MOF-exposed animals leading to marked renal impairment but only slightly enhanced F- production in d4-MOF animals leading to mild renal impairment. Thus, only in PB-pretreated animals could a biologically significant difference in nephrotoxicity be demonstrated for MOF and d4-MOF.
D000758:Anesthesia; D000818:Animals; D003903:Deuterium; D004790:Enzyme Induction / Q000187:drug effects; D005459:Fluorides / Q000378:metabolism; D007668:Kidney / Q000187:drug effects*; D007674:Kidney Diseases / Q000139:chemically induced; D008297:Male; D008733:Methoxyflurane / Q000378:metabolism* / Q000633:toxicity; D010634:Phenobarbital / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D011916:Rats, Inbred F344
D008733:Methoxyflurane; D003903:Deuterium; D005459:Fluorides; D010634:Phenobarbital