Ultrastructural changes in skeletal muscles in dengue virus-infected mice.
Dengue type 2 virus was inoculated intracerebrally in 20 adult swiss albino mice. Thigh muscles were removed after 24 h 3, 5 and 7 days after virus inoculation. Electron microscopic studies of the striated muscles show destruction of myofibrils, rarification of the sarcoplasmic reticulum network and changes in the mitochondria. Aggregates of electron-dense material as well as glycogen particles were also seen in the cytoplasm.
D000818:Animals; D003715:Dengue / Q000473:pathology*; D005260:Female; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D008931:Mitochondria, Muscle / Q000648:ultrastructure; D009132:Muscles / Q000648:ultrastructure*; D012519:Sarcoplasmic Reticulum / Q000648:ultrastructure; D013848:Thigh; D013997:Time Factors