title: Massive diphenhydramine overdose resulting in death.
abstract: Overdosage of diphenhydramine may result in the development of anticholinergic symptoms, seizures, and coma. A fatal outcome following a diphenhydramine overdose does not commonly occur. This report describes the largest documented overdosage of diphenhydramine (7.5 g) which resulted in the death of a 14-year-old girl. The patient initially developed seizures following by cardiac conduction and hemodynamic compromise resulting in death despite life support measures.
mesh_terms: D000293:Adolescent; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D004155:Diphenhydramine / Q000506:poisoning*; D005260:Female; D005751:Gastric Lavage; D006323:Heart Arrest / Q000628:therapy; D006801:Humans; D012151:Resuscitation; D012640:Seizures / Q000139:chemically induced; D013405:Suicide
chemical_list: D004155:Diphenhydramine