Effect of eboracin on convulsive seizures in mice: enhancement of myoclonus and inhibition of the tonic phase.
Eboracin, a substituted trioxyindenopyrrole, inhibited the tonic component of convulsive seizures induced in mice by pentylenetetrazol, electroshock or auditory stimulation. Single doses decreased the incidence of tonic-clonic seizures (ED50=28-35 mg/kg); complete inhibition of tonus followed doses of 40-150 mg/kg. A dose of 75-150 mg/kg of eboracin prolonged the duration and increased the severity of the myoclonic component of seizures induced by pentylenetetrazol.
D000161:Acoustic Stimulation; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D004597:Electroshock; D007192:Indenes / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009207:Myoclonus / Q000503:physiopathology*; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010672:Phenytoin / Q000494:pharmacology; D012640:Seizures / Q000503:physiopathology*
D000927:Anticonvulsants; D007192:Indenes; C034547:eboracin; D010672:Phenytoin; D010433:Pentylenetetrazole