Induction of neonatal rat skin and liver aryl hydrocarbon hydroxylase by coal tar and its constituents.
Topical application of coal tar solution (USP) to neonatal rats resulted in the induction of skin and liver aryl hydrocarbon hydroxylase (AHH) activities. Furthermore indirect exposure of the animals to coal tar vapors resulted in induction of the enzyme in skin and liver. Cutaneous application of coal tar to pregnant rats resulted in induction of skin and liver AHH activity in both mothers and prenatal rats. Among several defined constituents of coal tar tested benzo(a)pyrene (BP), anthracene and acridine were found to have measurable induction effects on neonatal rat skin and liver AHH. These studies indicate that therapeutic coal tar solution as well as selected defined chemical constituents of coal tar are capable of altering the activity of AHH in skin and liver.
D000166:Acridines / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D000873:Anthracenes / Q000494:pharmacology; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis*; D001554:Benzene / Q000494:pharmacology; D001580:Benzopyrenes / Q000494:pharmacology; D003033:Coal Tar / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D008099:Liver / Q000201:enzymology*; D009281:Naphthalenes / Q000494:pharmacology; D051381:Rats; D012867:Skin / Q000201:enzymology*
D000166:Acridines; D000873:Anthracenes; D001580:Benzopyrenes; D009281:Naphthalenes; D003033:Coal Tar; D001189:Aryl Hydrocarbon Hydroxylases; D001554:Benzene