Hepatic veno-occlusive disease caused by 6-thioguanine.
Clinically reversible veno-occlusive disease of the liver developed in a 23-year-old man with acute lymphocytic leukemia after 10 months of maintenance therapy with 6-thioguanine. Serial liver biopsies showed the development and resolution of intense sinusoidal engorgement. Although this disease was clinically reversible, some subintimal fibrosis about the terminal hepatic veins persisted. This case presented a unique opportunity to observe the histologic features of clinically reversible hepatic veno-occlusive disease over time, and may be the first case of veno-occlusive related solely to 6-thioguanine.
D000328:Adult; D006503:Hepatic Veins; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D008099:Liver / Q000473:pathology; D008297:Male; D013866:Thioguanine / Q000009:adverse effects*; D014652:Vascular Diseases / Q000139:chemically induced / Q000473:pathology
D013866:Thioguanine