title: A temporal analysis of naloxone's suppressant effect on drinking.
abstract: Licking activity was monitored in water deprived rats following various doses of naloxone. It was found that naloxone, at doses ranging from 0.01 to 10.0 mg/kg, had very little effect on initial drinking. However, naloxone did slow sustained drinking after 2 to 6 min into the bout, dependent upon dose. We takes these results to mean that naloxone is interfering with those processes which serve to sustain continued drinking throughout a drinking bout.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009270:Naloxone