title: Effect of sodium- or chloride-deficient medium on fast axonal transport in frog spinal nerves.
abstract: Fast axonal transport of radiolabeled proteins was studied in vitro in desheathed spinal nerves from frog. The replacement of the NaCl of the medium by LiCl reduced by 58% the amount of radiolabeled proteins which accumulated at a ligature, but its replacement by choline chloride did not inhibit transport. The replacement of NaCl by sodium isethionate led to a 32% reduction in the quantity of protein-bound radioactivity at the ligature. The results suggest that Cl-ions are essential to maintain fast axonal transport, and that Na+ may also be important.
mesh_terms: D000818:Animals; D001001:Anura / Q000378:metabolism; D001369:Axons / Q000378:metabolism*; D001693:Biological Transport, Active / Q000187:drug effects*; D002712:Chlorides / Q000494:pharmacology*; D003470:Culture Media / Q000494:pharmacology*; D066298:In Vitro Techniques; D012964:Sodium / Q000494:pharmacology*
chemical_list: D002712:Chlorides; D003470:Culture Media; D012964:Sodium