Regression of dense deposits in Type II membranoproliferative glomerulonephritis: case report of clinical course in a child.
The clinical course and follow-up of a child who presented with rapidly progressive renal failure due to dense deposit disease is described. The patient showed a dramatic response to immunosuppressive and anticoagulent therapy. Two and a half years later, a follow-up renal biopsy showed regression of the intramembranous dense deposits on electron microscopy. The unusually slow progression of renal failure in this patient has been of interest and its possible relationship with either the disappearance of dense deposits or the initial therapy received are discussed.
D001379:Azathioprine / Q000627:therapeutic use; D002675:Child, Preschool; D004176:Dipyridamole / Q000627:therapeutic use; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000473:pathology; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007678:Kidney Glomerulus / Q000648:ultrastructure; D008854:Microscopy, Electron; D011241:Prednisone / Q000627:therapeutic use
D004176:Dipyridamole; D006493:Heparin; D001379:Azathioprine; D011241:Prednisone