[Changes in the enzyme activity of the hydroxylating system of the rat liver endoplasmic reticulum in ischemia].
Local disturbance of liver circulation for 40 minutes did not lead to any substantial changes in the hydroxylation system of microsomes of the ischemized area. 60-, 120- and 180-minute circulation distress causes a progressing decrease in amidopyrine and aniline metabolism, diminution of the content of cytochrome P-450 in the microsomes, and of the activity of NADP.H-ferricytochrome-c-reductase, NADP.H-neotetrazolium-reductase and NADP.H-oxidase. After 120-minute ischemia hydrophobic properties of the microsomal membranes were found to be decreased.
D000818:Animals; D004721:Endoplasmic Reticulum / Q000201:enzymology*; D006801:Humans; D006900:Hydroxylation; D007511:Ischemia / Q000201:enzymology*; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000098:blood supply* / Q000201:enzymology; D008862:Microsomes, Liver / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D013997:Time Factors
D008054:Lipid Peroxides; D006899:Mixed Function Oxygenases
Izmenenie aktivnosti fermentov gidroksiliruiushcheĭ sistemy éndoplazaticheskogo retikuluma pecheni krys pri ishemii.