title: Thiamine deficiency limits glucose utilization and glial proliferation in brain lesions of symptomatic rats.
abstract: The effects of thiamine (B1) deficiency on local CMRglu (LMCRglu) in the vestibular nuclei were studied with the 14C-2-deoxyglucose autoradiographic method in awake asymptomatic and symptomatic rats. Animals on the B1-deficient diet for 98 days developed symptoms of ataxia and opisthotonos. The results show that B1 deficiency produces: (1) bilateral vestibular nuclei lesions in symptomatic animals; (2) very low LCMRglu rates in these lesions; and (3) limitation of glial proliferation in the lesions. Giving B1 to B1-deficient symptomatic animals produced a cellular proliferation response consisting mostly of microglia in the lesioned areas of the vestibular nuclei and a high LCMRglu rate in the regions of microglial proliferation.
mesh_terms: D000818:Animals; D002455:Cell Division; D005260:Female; D005947:Glucose / Q000378:metabolism*; D009457:Neuroglia / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013832:Thiamine Deficiency / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D014726:Vestibular Nuclei / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology
chemical_list: D005947:Glucose