Production of deferriferrioxamines B and E from a ferroverdin-producing Streptomyces species.
When Streptomyces sp. strain Wak. A-305 is cultured in iron (III)- or cobalt (II)-containing media, tris(p-vinylphenyl-4-hydroxy-3-nitrosobenzoato-N3, O4)ferrate(II) (ferroverdin) or the analogous tris-cobalt(III) complex, respectively, is produced intracellularly. In contrast, when cultured in transition metal ion-limiting media. Streptomyces sp. strain Wak. A-305 did not produce p-vinylphenyl 4-hydroxy-3-nitrosobenzoate (deferroferroverdin). Instead, deferriferrioxamines B and E, which have been characterized from other streptomycetes, were isolated extracellularly and may act as siderophores in this organism.U
D002712:Chlorides; D003035:Cobalt; D003470:Culture Media; D003676:Deferoxamine / Q000096:biosynthesis*; D005290:Ferric Compounds; D005296:Ferrous Compounds; D007502:Iron Chelating Agents; D009603:Nitroso Compounds; D010456:Peptides, Cyclic / Q000096:biosynthesis*; D010636:Phenols / Q000096:biosynthesis*; D013302:Streptomyces / Q000378:metabolism*
D002712:Chlorides; D003470:Culture Media; D005290:Ferric Compounds; D005296:Ferrous Compounds; D007502:Iron Chelating Agents; D009603:Nitroso Compounds; D010456:Peptides, Cyclic; D010636:Phenols; C033515:ferroverdin; D003035:Cobalt; C018021:cobaltous chloride; D003676:Deferoxamine; C033516:deferrioxamine E; C024555:ferric chloride