Osmium tetroxide in antigen-induced arthritis: failure to inhibit joint destruction.
Antigen induced arthritis (AIA) was elicited in 28 adult rabbits using ovalbumin. All animals developed an intensive monarthritis manifested by local heat and swelling. Two, 7 and 21 days later, respectively, 0.3 ml of 1 per cent OsO4 was injected into the arthritic knees of three groups of 9 rabbits. The rabbits were killed 1, 3 and 6 months later. No modifying influence on the severe to complete cartilage destruction was evident. One group of 8 rabbits received only OsO4 and the cartilage of these animals remained intact after 6 months.
D000818:Animals; D001168:Arthritis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D002356:Cartilage / Q000187:drug effects / Q000473:pathology; D007719:Knee Joint; D009336:Necrosis; D009992:Osmium / Q000627:therapeutic use*; D009993:Osmium Tetroxide / Q000009:adverse effects / Q000627:therapeutic use*; D010047:Ovalbumin; D011817:Rabbits; D013997:Time Factors
D009992:Osmium; D010047:Ovalbumin; D009993:Osmium Tetroxide