Cholinergic disinhibition in hippocampal slices of the rat.
In hippocampal slices of the rat maintained in vitro the addition of carbachol to the perfusion medium caused a depolarization accompanied by a conductance decrease and a block of inhibitory postsynaptic potentials in CAl pyramidal cells. During tetrodotoxin poisoning a smaller depolarization with conductance decrease was observed. Atropine blocked the effects of carbachol.
D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D004553:Electric Conductivity; D004558:Electric Stimulation; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D008297:Male; D009474:Neurons / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013779:Tetrodotoxin / Q000633:toxicity
D013779:Tetrodotoxin; D002217:Carbachol