Respiratory and cardiovascular effects of intraventricular cholecystokinin.
Cholecystokinin (1-300 ng) was administered into the lateral brain ventricle of chloralose-anesthetized cats while monitoring tracheal airflow, arterial blood pressure, and heart rate. Dose-related increases in respiratory activity occurred in each animal tested, and were due to an increase in tidal volume. When 300-1000 ng of cholecystokinin was administered intravenously, no respiratory stimulant effect was observed. These results indicate that cholecystokinin acts in the brain to stimulate respiration.
D000818:Animals; D002415:Cats; D002766:Cholecystokinin / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005755:Gastrins / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D012119:Respiration / Q000187:drug effects*
D005755:Gastrins; D002766:Cholecystokinin