Effects of pro-opiomelanocortin fragments on release of catecholamines from adrenal chromaffin cells.
The effects of pro-opiomelanocortin (POMC) peptide fragments on the basal and agonist-induced release of catecholamines (CAs) from monolayer cultures of purified bovine adrenal chromaffin cells were tested. None of the 5 peptides tested, i.e. beta-MSH, ACTH1-39, gamma-MSH1-13, gamma 3-MSH and N-terminal POMC fragment, had any effect on basal CA release. However, beta-MSH (10(-5) M), gamma-MSH1-13 (10(-6)-10(-5) M), gamma 3-MSH (10(-5) M) and N-terminal POMC fragment (10(-5) M) inhibited the nicotine-induced release of CAs from the chromaffin cells. The possible physiological significance of this inhibitory neuromodulation is discussed.
D000313:Adrenal Medulla / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D002417:Cattle; D002838:Chromaffin System / Q000187:drug effects*; D004759:Enterochromaffin Cells / Q000187:drug effects* / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D010446:Peptide Fragments / Q000494:pharmacology*; D010908:Pituitary Hormones, Anterior / Q000494:pharmacology*; D011333:Pro-Opiomelanocortin; D011498:Protein Precursors / Q000494:pharmacology*
D002395:Catecholamines; D010446:Peptide Fragments; D010908:Pituitary Hormones, Anterior; D011498:Protein Precursors; D011333:Pro-Opiomelanocortin; D009638:Norepinephrine