Elevated sister chromatid exchange rate in lymphocytes of the European eel (Anguilla anguilla) with cauliflower tumor.
Sister chromatid exchange (SCE) frequency and chromosomal aberration were studied in cultured lymphocytes from the European eel (Anguilla anguilla) with cauliflower tumors. SCE was significantly increased in the affected fishes compared with normal controls, whereas chromosomal aberration did not. In comparison to normal cells, the lymphocytes responding to phytohemagglutinin M (PHA-M) in cultures from tumorous eels showed no evidence of cell cycle retardation. A possible mechanism for elevation of SCE and the significance of this finding relation to the etiology were discussed.
D000811:Anguilla / Q000235:genetics*; D000818:Animals; D002869:Chromosome Aberrations; D003434:Crossing Over, Genetic; D005393:Fish Diseases / Q000235:genetics*; D008214:Lymphocytes / Q000648:ultrastructure; D012854:Sister Chromatid Exchange