title: [Regulatory mechanisms of oxygen transport function of hemoglobin in irradiated animals].
abstract: The oxygen affinity of hemoglobin of both common and 2,3-diphosphoglycerate concentration-purified erythrocyte hemolysates, hemoglobin stability, 2,3-diphosphoglycerate concentration in erythrocytes, morphological blood content were studied in rabbits irradiated with X-rays in a dose of 0.155 C/kg. An increase in the oxygen affinity of common hemolysate hemoglobin at a higher 2,3-diphosphoglycerate concentration on the 1st, 4th day after irradiation and a decrease in the oxygen affinity of both common and purified hemolysate hemoglobin on the 18th-30th day after irradiation were observed. A conclusion is made that disturbance of the hemoglobin function control by 2,3-diphosphoglycerate in irradiated animals is determined by alteration of protein physicochemical properties.
mesh_terms: D019794:2,3-Diphosphoglycerate; D000818:Animals; D004163:Diphosphoglyceric Acids / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism / Q000528:radiation effects*; D007700:Kinetics; D008297:Male; D010108:Oxyhemoglobins / Q000378:metabolism / Q000528:radiation effects*; D011817:Rabbits
chemical_list: D004163:Diphosphoglyceric Acids; D010108:Oxyhemoglobins; D019794:2,3-Diphosphoglycerate
vernacular_title: Issledovanie mekhanizmov reguliatsii kislorodtransportnoĭ funktsii gemoglobina u obluchennykh zhivotnykh.