Mechanisms of calcification in Peyronie's disease.
Scanning and transmission electron micrographs demonstrate a calcification process in the penile plaques of patients with Peyronie's disease. Osteoid formation originates from vascular lumina via osteoblast-like cells, which align the calcified plaque. These cells are surrounded gradually by calcified connective tissue. Collagen fibers demonstrate calcification and decreased periodicity.
D002114:Calcinosis / Q000473:pathology*; D006801:Humans; D008297:Male; D010006:Osteoblasts / Q000648:ultrastructure; D010411:Penile Induration / Q000473:pathology*; D010413:Penis / Q000098:blood supply / Q000648:ultrastructure*