Responses of single nerve fibres to capsaicin applied to the skin.
The responses of sensory nerve fibres to capsaicin solution topically applied to their cutaneous receptive fields were studied using the rat saphenous nerve. The polymodal nociceptors responded to capsaicin with discharge and subsequent densensitization to chemical, mechanical and thermal stimuli. Other types of C fibres, and A beta and A delta fibres, showed no response to capsaicin.
D000287:Administration, Topical; D000818:Animals; D002211:Capsaicin / Q000008:administration & dosage / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005260:Female; D008297:Male; D008465:Mechanoreceptors / Q000187:drug effects; D009412:Nerve Fibers / Q000187:drug effects*; D009619:Nociceptors / Q000187:drug effects; D051381:Rats; D011930:Reaction Time; D013823:Thermoreceptors / Q000187:drug effects; D013997:Time Factors
D005231:Fatty Acids, Unsaturated; D002211:Capsaicin