title: Werner's syndrome with associated malignant neoplasms.
abstract: Werner's syndrome is an autosomal recessive disease characterized by juvenile cataracts, scleroderma-like skin changes, and a high incidence of neoplasms. A 57-year-old man had Werner's syndrome associated with a fibrosarcoma of the mediastinum and multiple basal cell epitheliomas. In two of these basal cell epitheliomas, since the sclerotic skin made it difficult to assess the extent of the tumor, microscopically controlled excision (Mohs' chemosurgery technique) was employed.
mesh_terms: D002280:Basal Cell Carcinoma / Q000150:complications*; D005354:Fibrosarcoma / Q000150:complications*; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D009669:Nose Neoplasms / Q000150:complications*; D012878:Skin Neoplasms / Q000150:complications*; D014898:Werner Syndrome / Q000150:complications*