title: Disappearance rate of endogenously radioiodinated thyroglobulin and thyroxine after radioiodine treatment.
abstract: Endogenously radioiodinated thyroglobulin (tg) and thyroxine (T4), in the circulation following, therapeutic doses of radioiodine were studied in five patients with differentiated thyroid carcinoma. Radioactive serum was fractionated on a Sephadex G-200 and the various radioactive peaks thus obtained were analyzed for their biochemical and immunologic characteristics using precipitation with trichloroacetic acid (TCA) and antithyroglobulin antibody extraction with acidified n-butanol and electrophoresis on agar gel. The disappearance rates of endogenously labelled tg and T4 were 3.12 +/- 0.396 days and 10.14 +/- 1.81 days, respectively.
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D006207:Half-Life; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D007700:Kinetics; D009362:Neoplasm Metastasis; D011877:Radionuclide Imaging; D013954:Thyroglobulin / Q000097:blood*; D013964:Thyroid Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D013974:Thyroxine / Q000097:blood*
chemical_list: D007457:Iodine Radioisotopes; D013954:Thyroglobulin; D013974:Thyroxine