[Primary non-Hodgkin's lymphoma of the brain, sarcoidosis, thyroid cancer and immunity cell deficiency (author's transl)].
A 66-year-old man presented with a primary malignant lymphoma of the cerebellum and brain stem. The lymphoma was of type V (Bryon's classification) with predominant B cells, and was associated, as in previously reported cases, with a peripheral blood T lymphocyte deficiency. This case was unusual, in that autopsy revealed an active multivisceral sarcoidosis (considered as being cured more than 10 years previously), a clear-cell renal adenoma demonstrating nearly all the characteristics of a Grawitz's tumor, and a papillary epithelioma of the thyroid gland. These findings lead to discuss the significance of immuno-surveillance lack in this particular case: was it dependent on the sarcoidosis (during which a reduction in T lymphocytes is known to occur), or was it primary and perhaps genetic, a son of the patient having Hodgkin's disease? Whatever the case may be, the encephalic proliferation of the B lymphocyte clone, the peripheral epitheliomas, the sarcoidosis, and the deficit in T lymphocytes in the peripheral blood constitute a group of factors singularly rich in questions, this being, apparently, the first case of this type reported in the published literature.
D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology; D001932:Brain Neoplasms / Q000276:immunology*; D001933:Brain Stem / Q000276:immunology; D002528:Cerebellar Neoplasms / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006801:Humans; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007958:Leukocyte Count; D008223:Lymphoma / Q000276:immunology*; D008297:Male; D012507:Sarcoidosis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D013964:Thyroid Neoplasms / Q000276:immunology*
Lymphome non hodgkinien "primitif" de l'encéphale. Sarcoïdose. Cancer thyroïdien. Déficit immunitaire cellulaire.