Elimination of monomeric, dimeric and polymeric human albumin from the plasma of inbred mice and dissociation of natural albumin polymers.
Covalently linked albumin dimers and polymers had plasma half-lives (t 1/2s) in mice which were not significantly different from that of native albumin. The elimination of a chemically treated albumin monomer was also not appreciably different from that of the native protein, but it was significantly faster than covalently linked albumin dimers and polymers. Essentially similar results were obtained when natural monomers, dimers and trimers were compared, although precise t 1/2 data may have been affected by the dissociation of natural polymers into appreciable amounts of monomer in vivo.
D000818:Animals; D006207:Half-Life; D006801:Humans; D051379:Mice; D008809:Mice, Inbred C3H; D011108:Polymers / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism*
D011108:Polymers; D012709:Serum Albumin