The effect of alinidine (St 567) on emotionally induced tachycardia in man.
Experiments were performed in a randomized double-blind cross-over study in 6 healthy volunteers to answer the question if alinidine, a new analogue of clonidine with a bradycardic effect directly on the sinus node, would have an effect on an emotionally-induced tachycardia. Alinidine 40 mg orally significantly (1%) reduced the tachycardia and the concomitant rise in diastolic blood pressure during the stress of performing a mental task. Forearm blood flow and the efficiency (total score in the mental task) remained unchanged by alinidine.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004341:Drug Evaluation; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D013315:Stress, Psychological / Q000150:complications; D013610:Tachycardia / Q000188:drug therapy* / Q000209:etiology
C022192:alinidine; D003000:Clonidine