title: Inhibition of the incorporation of 14C-precursors in Mycobacterium smegmatis by antibiotics and chemotherapeutics.
abstract: Twenty antituberculostatics and twelve other compounds were divided into three groups according to their ability to influence the rate of incorporation of 14C-adenine and 14C-leucine in M. smegmatis. The first group includes compounds significantly inhibiting the incorporation of 14C-leucine, the second group comprises compounds inhibiting simultaneously the incorporation of both 14C-precursors, the third group contains compounds that do not bring about a 50% decrease of the rate of incorporation even at a concentration of 400 micrograms/mL.
mesh_terms: D000225:Adenine / Q000378:metabolism; D000904:Antibiotics, Antitubercular / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D002250:Carbon Radioisotopes; D003470:Culture Media; D007930:Leucine / Q000378:metabolism; D009161:Mycobacterium / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000904:Antibiotics, Antitubercular; D000995:Antitubercular Agents; D002250:Carbon Radioisotopes; D003470:Culture Media; D007930:Leucine; D000225:Adenine