A biologically active receptor for the carbohydrate-binding protein(s) of Dictyostelium discoideum.
Recent biochemical and genetic evidence has shown that carbohydrate-binding protein (CBP-26) is intimately involved in the cell-cell cohesion process. We have isolated a cell-surface-associated receptor molecule for CBP-26 by affinity chromatography. The receptor has a molecular weight of 80,000 daltons. The CBP receptor is constitutively expressed during development. Most significantly, the receptor, when added to aggregation-competent cells, blocks the cells' ability to reaggregate. These results suggest that CBP and its receptor play an important role in the cell cohesion and aggregation process.
D002449:Cell Aggregation; D004023:Dictyostelium / Q000166:cytology*; D005690:Galactose / Q000378:metabolism; D005786:Gene Expression Regulation; D006023:Glycoproteins / Q000502:physiology*; D037102:Lectins; D008970:Molecular Weight; D011485:Protein Binding; D011975:Receptors, Mitogen / Q000302:isolation & purification / Q000378:metabolism*
D006023:Glycoproteins; D037102:Lectins; D011975:Receptors, Mitogen; D005690:Galactose