[Biochemical bases of the anti-ulcer action of GABA and sodium oxybate].
It was found that GABA and sodium hydroxybutyrate are capable to prevent gastric ulcers. While protecting the animals from experimental ulcers both the substances display an ability to increase the content of ATP in the gastric wall. ATP that prevents the occurrence of experimental gastric ulcers enhances 14-leucine incorporation into proteins of gastric tissues. It was demonstrated in experiments ulcer prevention that under the effect of 32P-ATP the content of phosphorylated proteins in gastric tissues rises more than 2-fold. This circumstances ensures the increased resistance of the gastric mucosa to the action of proteolytic enzymes. Enhancement of oxygen consumption by the tissues should be also regarded as one of the factors determining high resistance of the mucosa to proteolysis.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D006885:Hydroxybutyrates / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D014176:Protein Biosynthesis; D051381:Rats; D012978:Sodium Oxybate / Q000494:pharmacology*; D013276:Stomach Ulcer / Q000188:drug therapy*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000897:Anti-Ulcer Agents; D006885:Hydroxybutyrates; D005680:gamma-Aminobutyric Acid; D012978:Sodium Oxybate; D000255:Adenosine Triphosphate
Biokhimicheskie osnovy protivoiazvennogo deĭstviia GAMK i natriia oksibutirata.