title: Inhibitory effects of four isoabrins on the growth of sarcoma 180 cells.
abstract: The four isoabrins were shown to be capable of inhibiting the growth of tumor cells in vivo when one-fifth of their median lethal dose was used. From the in vitro experiments, the doses required for 50% inhibition of protein biosynthesis are 3.2 pg, 45 ng, 32 ng, and 10 ng/ml for abrin-a, -b, -3, and -d, respectively. Except for abrin-b, a good correlation between the inhibitory effects of abrins on the tumor growth and protein biosynthesis was observed. These isoabrins show a moderate inhibitory effect on DNA biosynthesis.
mesh_terms: D000036:Abrin / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D051379:Mice; D009363:Neoplasm Proteins / Q000096:biosynthesis; D010940:Plant Proteins / Q000627:therapeutic use*; D012513:Sarcoma, Experimental / Q000188:drug therapy*
chemical_list: D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D010940:Plant Proteins; D000036:Abrin