[GABA-ergic component in the action of the tranquilizing agent mebikar].
The paper is concerned with studies into the effect of the tranquilizer mebicar, a derivative of tetra-N-alkyl bicyclic bisureas, on the GABA-ergic system. The drug in doses of 250-1500 mg/kg (1/15-1/2 LD50) increased the preconvulsive period upon thiosemicarbazide administration, inconsistently changed the effects of picrotoxin and displayed antagonism in regard to bicucullin. Upon 2-week administration the drug reduced the GABA content in the rat brain. A hypothesis is advanced of mebicar-associated facilitation of the inhibitory GABA-ergic transmission.
D000818:Animals; D001640:Bicuculline / Q000037:antagonists & inhibitors; D001736:Biureas / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D003864:Depression, Chemical; D004347:Drug Interactions; D008297:Male; D051379:Mice; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D012663:Semicarbazides / Q000037:antagonists & inhibitors; D014149:Tranquilizing Agents / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D001640:Bicuculline; D001736:Biureas; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D010852:Picrotoxin; D012663:Semicarbazides; D014149:Tranquilizing Agents; D005680:gamma-Aminobutyric Acid; C015979:mebikar; C005151:thiosemicarbazide
GAMK-érgicheskiĭ komponent v deĭstvii trankvilizatora mebikara.