Erythroid progenitors in paroxysmal nocturnal haemoglobinuria.
In vitro colony formation of bone-marrow erythroid progenitor cells in patients with paroxysmal nocturnal haemoglobinuria (PNH) was examined. The numbers of early and late erythroid progenitors (BFU-E and CFU-E) showed wide variations; two cases out of eight cases of PNH showed decreased erythroid colony formation, but other cases showed normal or rather increased colony formation of BFU-E and CFU-E. The number of erythroid progenitors in patients with PNH may be related to the marrow cellularity.
D000328:Adult; D000368:Aged; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D004912:Erythrocytes; D005260:Female; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006457:Hemoglobinuria, Paroxysmal / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged