title: Auditory stimulation alters the pattern of 2-deoxyglucose uptake in the inner ear.
abstract: The 2-deoxy-D-glucose (2-DG) autoradiographic technique was adapted for application to the inner ear. The uptake of [14C]-DG during silence was compared with that observed during exposure to wide band noise (WBN) or pure tones at an intensity level of 85 db SPL. In silence, the highest levels of 2-DG uptake were observed in the spiral ligament, spiral prominence and stria vascularis, with approximately equal levels of uptake in each structure. The high levels of 2-DG uptake observed in the ligament and prominence are surprising, and suggest a more active role for these structures in cochlear function than has previously been suspected. Levels of uptake in the organ of Corti, spiral ganglion and VIIIth nerve were much lower, although well above background. During exposure to WBN, 2-DG uptake increased markedly in the VIIIth nerve, and spiral ganglion throughout the cochlea, and in the organ of Corti in the lower basal turn. 2-DG uptake did not change significantly in the spiral ligament or stria vascularis. During pure tone exposure, increased 2-DG uptake was noted in localized regions of the VIIIth nerve and spiral ganglion.
mesh_terms: D000818:Animals; D001307:Auditory Perception / Q000502:physiology*; D001786:Blood Glucose / Q000378:metabolism*; D003051:Cochlea / Q000294:innervation; D003056:Cochlear Nerve / Q000378:metabolism; D003847:Deoxyglucose / Q000097:blood; D007758:Ear, Inner / Q000294:innervation*; D005072:Evoked Potentials, Auditory; D005849:Gerbillinae; D009925:Organ of Corti / Q000294:innervation; D010498:Perilymph / Q000378:metabolism; D010898:Pitch Perception / Q000502:physiology; D013136:Spiral Ganglion / Q000378:metabolism; D000159:Vestibulocochlear Nerve / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D003847:Deoxyglucose