title: Multiple primary carcinomas of the head, neck, and lung.
abstract: The case histories of 8,956 patients treated for primary malignancies arising in the lung, head and neck, or both were reviewed. Eighty-five (21%) of 406 patients with primary bronchogenic malignancy associated with neoplasms at other sites had head and neck malignancies; they comprise 0.9% of the total and form the basis of this report. The head and neck malignancy preceded bronchogenic carcinoma in 70 patients; bronchogenic carcinoma occurred first in 8 patients; and malignancies occurred in both sites synchronously in 7 patients. Case histories and tabular analysis of pathology, social history, time interval between lesions, treatment, and survival are presented. A strong association between heavy cigarette smoking, alcoholism, and multicentric respiratory tract malignancies is noted. Critical analysis supports aggressive treatment of each lesion as a separate solitary primary malignancy.
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery / Q000628:therapy; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002277:Carcinoma / Q000628:therapy; D002283:Carcinoma, Bronchogenic / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D005260:Female; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000628:therapy*; D011013:Pneumonectomy; D012004:Rectal Neoplasms / Q000601:surgery; D012907:Smoking
chemical_list: D000970:Antineoplastic Agents