[Characteristics of isoenzymes of glucose-6-phosphate dehydrogenase in estrogen-dependent and estrogen-independent mammary tumors of experimental animals].
Estrogen-dependent and estrogen-independent mammary tumours were produced in experimental animals. Four isozymes of glucose 6-phosphate dehydrogenase were identified in each tumour tupe. It was found that ovariectomy and estradiol administration change selectively the activity of glucose 6-phosphate dehydrogenase I in estrogen-dependent tumours, while no effect on the enzyme or any of its isozymes was found in estrogen- in dependent tumours. Other hormones (prolactin, insulin) induce the activity of glucose 6-phosphate dehydrogenase III rather than that of glucose 6-phosphate dehydrogenase I in normal mammary tissue. The idea of existence of a fine regulation of the enzyme activity through selective activation or repression of individual isozymes is confirmed.
D000818:Animals; D002369:Castration; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology; D007527:Isoenzymes / Q000378:metabolism*; D008325:Mammary Neoplasms, Experimental / Q000201:enzymology*; D011388:Prolactin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D007527:Isoenzymes; D004958:Estradiol; D011388:Prolactin; D005954:Glucosephosphate Dehydrogenase
Kharakteristika izofermentov gliukozo-6-fosfatdegidrogenazy v éstrogenzavisimykh i éstrogennezavisimykh opukholiakh molochnykh zhelez éksperimental'nykh.