Chemoimmunotherapy for autochthonous acute rat leukemias.
Eighty autochthonous acute rat leukemias that had been induced by ethylnitrosourea were used to compare the effect of single-drug therapy with vincristine, doxorubicin, or cytarabine with the effect of combination therapy using these three drugs with or without BCG-Pasteur F. The combination chemotherapy was clearly superior to the single-drug therapy. The best results (survival time; duration of remission) were achieved by vincristine, doxorubicin, and cytarabine plus BCG, although compared to the combinations without BCG, these results were not significant.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001500:BCG Vaccine / Q000627:therapeutic use; D003561:Cytarabine / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005038:Ethylnitrosourea; D007942:Leukemia, Experimental / Q000139:chemically induced / Q000628:therapy*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014750:Vincristine / Q000627:therapeutic use
D000970:Antineoplastic Agents; D001500:BCG Vaccine; D003561:Cytarabine; D014750:Vincristine; D004317:Doxorubicin; D005038:Ethylnitrosourea