A modified life table method to study congenital genetic disorders: an application in sickle cell anemia.
A modified life table procedure is introduced designed to study the survival of patients with congenital genetic disorders with the endpoint defined by a complication or death. It uses the ages of the patients as the time axis as in "population' or "current' life tables, and it allows patients to enter and exit the study as in survival life tables. The procedure uses the exact length of time that each patient is observed in the study to determine the conditional probabilities of developing the complication. The proposed procedure is especially helpful in studying recurrent complications or events that occur frequently. The proposed life table procedure is demonstrated in the study of the conditional probability of developing a sickle cell crisis in 509 patients with sickle cell anemia (SS) with different number of prior crises. The demonstration is intended to illustrate the use of the proposed method and not to investigate the clinical severity of sickle cell anemia. It was found that the risk of crisis was to investigate the clinical severity of sickle cell anemia. It was found that the risk of crisis was positively related to the number of prior crises in SS patients (P less than 0.001). This trend was significant in the first three decades of life.
D000206:Actuarial Analysis / Q000379:methods*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000755:Anemia, Sickle Cell / Q000401:mortality*; D002648:Child; D002675:Child, Preschool; D005260:Female; D030342:Genetic Diseases, Inborn / Q000401:mortality*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011336:Probability; D012008:Recurrence; D012306:Risk