Calcium and age in fibroblasts from control subjects and patients with cystic fibrosis.
Intracellular calcium increases significantly as human fibroblasts age in culture. The calcium increase occurs 5 to 6 weeks (passages) earlier and is significantly greater in fibroblasts from subjects with cystic fibrosis in comparison with cells from control subjects. Intracellular calcium, which is thought to be a pathogenetic factor in cystic fibrosis, may also be a meaningful marker in cell aging.
D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000378:metabolism*; D002470:Cell Survival; D002478:Cells, Cultured; D002648:Child; D003550:Cystic Fibrosis / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005347:Fibroblasts; D006801:Humans; D007223:Infant; D008297:Male
D002118:Calcium