[Histomorphometric study of nonpagetic bone in Paget patients. Results before and after diphosphonates].
An histomorphometric study with double tetracycline labelling was carried out on iliac biopsies taken from patients suffering from Paget's bone disease; 64 of the cases revealed non-pagetic bone in radiology, and 72 revealed a pagetic incidence. The purpose was to better compare non-pagetic bone with pagetic bone. 5 biopsies performed in a radiologically non-pagetic area were shown to be histologically pagetic. An histomorphometric profile of non-pagetic bone in a patient suffering from Paget's disease was established: increase in the reabsorption surfaces, of the periosteocytic uneven surfaces, of the volume and of the osteoid surfaces in the women; decrease in the osteoid thickness indicator and in the speed of normal calcification. These signs of hyperremodelling were, for the authors, connected with a hyperparathyroid condition which was secondary to calcium needs in the pagetic areas. The effects of diphosphonates on non-pagetic bone in the patients suffering from Paget's disease are clarified. This therapy has a beneficial action on the bone volume of non-pagetic bone, when the initial bony trabecular column is small.
D001842:Bone and Bones / Q000473:pathology*; D002114:Calcinosis / Q000188:drug therapy; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007085:Ilium / Q000473:pathology; D008297:Male; D010001:Osteitis Deformans / Q000188:drug therapy / Q000473:pathology*; D013997:Time Factors
D004164:Diphosphonates
Etude histomorphométrique de l'os non pagétique chez le pagétique. Résultats avant et après diphosphonates.