title: Effect of tocopherol deficiency on lipid metabolism in arterial wall of spontaneously hypertensive rats on normal and high cholesterol diets.
abstract: Lipid metabolism in the arterial wall of spontaneously hypertensive rats (SHR) fed on tocopherol-deficient diet, high-cholesterol diet or both was studied. Serum tocopherol was greatly decreased in tocopherol-deficient SHR. Lipoperoxide, determined as thiobarbituric acid-reactive substances, was higher in tocopherol-deficient SHR than in normal SHR. Tocopherol-deficient SHR showed a decrease in acid cholesterol esterase activity, but no change in neutral cholesterol esterase, acid and neutral lipase, acyl CoA synthetase, cytidine-diphosphate choline-1-2-diacyl glycerol choline phosphotransferase (CPT) or triglyceride synthesizing activity.
mesh_terms: D000818:Animals; D001158:Arteries / Q000378:metabolism*; D002791:Cholesterol, Dietary / Q000009:adverse effects*; D006973:Hypertension / Q000378:metabolism*; D050356:Lipid Metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D002787:Sterol Esterase / Q000097:blood; D014811:Vitamin E Deficiency / Q000378:metabolism*
chemical_list: D002791:Cholesterol, Dietary; D002787:Sterol Esterase