Cutaneous erythema and blood pressure lowering effects of topically applied 16-vinylprostaglandins.
Topically applied 16-vinylprostaglandins demonstrate the property of rapid transit through the skin and a profound effect on the cutaneous vasculature. At low concentrations in the guinea pig and rabbit. 15-deoxy-16-hydroxy-16-vinyl-PGE2 (DHV-PGE2) and its methyl ester (DHV-PGE2Me) elicit a distinct and persistent erythema which is restricted to the area of application and is not associated with a wheal. Skin temperatures are elevated for several hours following application. Accordingly, these compounds may have therapeutic utility in conditions where local blood flow is compromised or where an enhanced blood flow is desired . In the spontaneously hypertensive rat, topically applied DHV-PGE2 and DHV-PGE2Me produce a dramatic and persistent lowering of blood pressure. The maximal effects are comparable to those obtained wit equal oral or intravenous doses and are maintained for a longer period of time. Moreover, with the topical route, there is no prolongation in the time required for onset of action (3-5 minutes). It appears that while the skin presents only a minimal diffusion barrier to these compounds, a sufficient depot is maintained to give sustained release and prolonged duration. Transdermal delivery of 16-vinyl prostaglandins may offer a convenient means of achieving a clinical antihypertensive effect without the characteristic side effects generally associated with oral or intravascular prostaglandins.
D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D015232:Dinoprostone / Q000031:analogs & derivatives*; D004837:Epinephrine / Q000494:pharmacology; D004890:Erythema / Q000139:chemically induced*; D006168:Guinea Pigs; D007275:Injections, Intravenous; D008297:Male; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012881:Skin Temperature / Q000187:drug effects
D011459:Prostaglandins E, Synthetic; C034231:15-deoxy-16-hydroxy-16-vinylprostaglandin E2; D015232:Dinoprostone; C034232:viprostol; D004837:Epinephrine