Variation in the hepatotoxic effects of carbon disulphide in the rat: evidence for polygenic inheritance.
The hepatotoxic effects of carbon disulphide have been examined in rats obtained from a series of crosses between two inbred strains which differ widely in their susceptibility. The distribution of susceptibility in the F2 generation indicates that the variation cannot be explained by a simple genetic model. A polygenic model is a more likely explanation.
D000818:Animals; D002246:Carbon Disulfide / Q000633:toxicity*; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D005260:Female; D014644:Genetic Variation; D005823:Genetics; D008099:Liver / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics; D013045:Species Specificity
D003577:Cytochrome P-450 Enzyme System; D002246:Carbon Disulfide