Genetic and sex-linked factors influencing HBs antigen clearance. I. Nonimmune clearance in inbred strains of mice.
Differences in the clearance values of polyvinylpyrrolidone (KPVP) and HBs antigen (KHBs) were seen in several strains of inbred mice. In addition, in all strains studied KHBs was greater in females than in males, while KPVP was not significantly different in the two sexes. In the strain with the lowest KHBs values, the incidence of HBs antibody formation was lower than in the other strains. These data indicate that genetic and sex-linked factors influence nonimmune clearance of HBs antigen in mice. If similar factors exist in man they may explain some of the variation in clinical manifestation of HBV infection.
D000818:Animals; D000917:Antibody Formation; D005260:Female; D006509:Hepatitis B / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000096:biosynthesis; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011205:Povidone / Q000276:immunology; D012737:Sex Factors
D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D011205:Povidone