In vitro coagulant properties of venoms from Australian snakes.
The procoagulant properties of venous Australian snakes are limited to prothrombin activation. Venoms of Notechis scutatus, Tropidechis carinatus and Pseudechis porphyriacus require phospholipid, calcium and factor V to maximally activate normal prothrombin. Venoms of Pseudonaja textilis and Oxyuranus microlepidotus activate both normal prothrombin and the decarboxy form and do not require co-factors. The actions of the venom of Oxyuranus scutellatus are dependent on concentration.
D000818:Animals; D001315:Australia; D001777:Blood Coagulation / Q000187:drug effects*; D003029:Coagulants; D004546:Elapid Venoms / Q000633:toxicity*; D006801:Humans; D066298:In Vitro Techniques; D011516:Prothrombin / Q000378:metabolism; D012911:Snakes; D013045:Species Specificity
D003029:Coagulants; D004546:Elapid Venoms; D011516:Prothrombin