Effect of drug-induced platelet dysfunction on surgical bleeding.
Two hundred patients scheduled to undergo a variety of surgical and gynecologic procedures were studied to determine whether increased surgical bleeding occurred in those who had drug-induced platelet dysfunction. Twelve of 55 patients (22 percent) who had a positive drug history and abnormal platelet aggregation were judged to have excessive bleeding at surgery or postoperatively, compared with 7 of 97 patients (7 percent) with a negative drug history and normal platelet aggregation (p less than 0.02). The data suggest that drug-induced qualitative platelet dysfunction predisposes to excessive surgical bleeding.
D001780:Blood Coagulation Tests; D001791:Blood Platelet Disorders / Q000139:chemically induced*; D064420:Drug-Related Side Effects and Adverse Reactions; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D013514:Surgical Procedures, Operative / Q000009:adverse effects*