Coupling of histone and DNA synthesis in the somatic cell cycle.
The coupling of histone and DNA synthesis was examined in the temperature-sensitive hamster fibroblast cell line K12. By monitoring total cellular histone synthesis at various times after quiescent cells were stimulated to proliferate at permissive and nonpermissive temperatures, a direct correlation was found between the rates of DNA and histone synthesis. Furthermore, when DNA synthesis was blocked by the K12 mutation, histone synthesis was reduced to the basal rate.
D000818:Animals; D002453:Cell Cycle; D002460:Cell Line; D006224:Cricetinae; D004247:DNA / Q000096:biosynthesis; D004261:DNA Replication; D006657:Histones / Q000096:biosynthesis*; D009154:Mutation
D006657:Histones; D004247:DNA