[Effect of glucocorticoids and catecholamines on the state of the tissue lysosomal apparatus in rabbits with experimental diabetes].
Administration to rabbits of hydrocortisone (8 mg/kg) and adrenaline (0.3 ml of 0.1% solution) during mild dithizone diabetes simulated hormonal reconstructions of the body exposed to stress. Activation of the cellular lysosomal apparatus occurs in such hormonal situation. In the liver this in manifested by an increase in the acid phosphatase, cathepside D, and beta-glucosidase free activity and by reduction in the resistance of lysosomal membranes to the effect of osmotic shock. Increase in the total acid hydrolase activity was detected in the cardiac and skeletal muscles.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000201:enzymology*; D004230:Dithizone / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D009132:Muscles / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D011817:Rabbits; D013268:Stimulation, Chemical
D004230:Dithizone; D006854:Hydrocortisone; D004837:Epinephrine
Vliianie gliukokortikoidov i katekholaminov na sostoianie lizosomal'nogo apparats tkaneĭ krolikov s éksperimental'nym diabetom.