4-Chloromethylbiphenyl (4CMB)--an in vivo cytogenetic study in the Chinese hamster (Cricetulus griseus).
The study was part of the UK EMS Genetic Toxicology trial, to determine the clastogenic potential of 4CMB in the bone-marrow cell chromosomes of the Chinese hamster. At dose levels of 50, 100, 200, 300 and 400 mg/kg of 4CMB statistical analysis of the data failed to show any significant differences in chromosomal damage between negative controls and 4CMB-treated groups. However, numerical increases in chromosomal damage were observed in the 4CMB-treated groups. The aberrations were at a low frequency but included the more severe types of chromosomal damage, such as exchange figures and dicentric chromosomes.
D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects / Q000502:physiology; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D003520:Cyclophosphamide / Q000494:pharmacology; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*
D001713:Biphenyl Compounds; D009153:Mutagens; C033487:4-chloromethylbiphenyl; D003520:Cyclophosphamide