title: Use of uncoated activated carbon hemoperfusion in acute poisoning: in vitro studies.
abstract: In acute poisoning the main purpose of any therapeutic approach is a rapid removal of the drug or poison from body tissues. This approach suggested to undertake a study for the development of an uncoated activated carbon hemoperfusion column suitable for acute poisoning. Th clearances were significantly superior compared with a similar device manufactured using coated carbon. The microparticle generation, utilizing a spherical type of activated carbon, was undetectable with the adopted measuring method, well below the US and British Pharmacopeas limits and practically equal to a coated carbon column with identical geometry.
mesh_terms: D000208:Acute Disease; D000327:Adsorption; D000818:Animals; D001786:Blood Glucose; D001806:Blood Urea Nitrogen; D002244:Carbon / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D007444:Inulin / Q000097:blood; D010316:Particle Size; D010634:Phenobarbital / Q000097:blood; D011041:Poisoning / Q000188:drug therapy*; D011817:Rabbits; D012459:Salicylates / Q000097:blood; D020156:Salicylic Acid; D014527:Uric Acid / Q000097:blood; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D001786:Blood Glucose; D012459:Salicylates; D014527:Uric Acid; D002244:Carbon; D007444:Inulin; D003404:Creatinine; D020156:Salicylic Acid; D014805:Vitamin B 12; D010634:Phenobarbital