New dopaminergic and indoleamine-accumulating cells in the growth zone of goldfish retinas after neurotoxic destruction.
Juvenile goldfish were allowed to grow for 3 months after dopaminergic or indoleamine-accumulating cells in their retinas had been destroyed by intravitreal injection of 6-hydroxydopamine or 5,7-dihydroxytryptamine, respectively. New cells of each type were found growing in concentric rings at the margin of the retina. To compensate for the loss of dopaminergic innervation in retinas treated with 6-hydroxydopamine, cells in the growth zone appeared to proliferate at a higher rate than those in untreated retinas and long processes were extended into the retina by the first dopaminergic cells to appear.
D015115:5,6-Dihydroxytryptamine / Q000378:metabolism*; D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D006054:Goldfish; D006892:Hydroxydopamines / Q000494:pharmacology; D009416:Nerve Regeneration; D012160:Retina / Q000166:cytology / Q000187:drug effects / Q000502:physiology*
D006892:Hydroxydopamines; D015116:5,7-Dihydroxytryptamine; D004298:Dopamine; D015115:5,6-Dihydroxytryptamine