[Pharmacokinetic model studies of sulfamerazine in domestic mammals. 2. Elimination of Mebacid 200 and Mebacid tablets following oral, subcutaneous and intramuscular administration].
The mathematical foundations underlying pharmacokinetic testing and acceptance of medicaments for domestic mammals are expounded and discussed, with reference being made to examples of intramuscular, subcutaneous, and oral application of Mebacid 200 and Mebacid tablets. Elimination of sulphamerazine may be mathematically described by means of the following bi-exponential function: c = B x e-k2 x t -- A x e-k1 x t The concepts of the mono-compartmental model "Extravasal Application" can be claimed as being of basic validity. Blood levels established after intramuscular and subcutaneous application of sulphamerazine-sodium (Mebacid 200) were lower than those recorded after oral application of Mebacid tablets. The half-lives of elimination, following oral application to big animals of Mebacid tablets, were longer than those following intravenous application of comparable injection solution.
D000284:Administration, Oral; D000818:Animals; D000829:Animals, Domestic / Q000378:metabolism*; D002415:Cats; D002417:Cattle; D004285:Dogs; D005260:Female; D006736:Horses; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D008297:Male; D008954:Models, Biological; D013045:Species Specificity; D013416:Sulfamerazine / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D013607:Tablets
D013607:Tablets; D013416:Sulfamerazine
Pharmakokinetische Modelluntersuchungen an Sulfamerazin bei Haussäugetieren. 2. Mitteilung: Die Elimination von Mebacid 200 und Mebacid-Tabletten nach oraler, subkutaner und intramuskulärer Applikation.