title: Action spectrum for retinal injury from near-ultraviolet radiation in the aphakic monkey.
abstract: We found that the action spectrum for retinal damage (determined by the fundus photographic appearance of a minimal lesion immediately after exposure) extends into the near-ultraviolet by exposing three aphakic eyes from rhesus monkeys to 405-, 380-, 350-, and 320-nm wavelengths produced by a 2,500-W xenon lamp equipped with quartz optics and 10-nm interference filters. Exposure times were 100 and 1,000 seconds and the spot diameter on the retina was 500 micrometers. The retina was six times more sensitive to 350- and 325-nm wavelengths than to blue light (441 nm). Both ophthalmoscopic and histologic data showed that near-ultraviolet lesions differed in important respects from blue-light lesions. Near-ultraviolet produced irreparable damage to rod and cone photoreceptors.
mesh_terms: D000818:Animals; D001036:Aphakia, Postcataract / Q000150:complications*; D008253:Macaca mulatta; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000150:complications / Q000473:pathology; D012160:Retina / Q000473:pathology / Q000528:radiation effects*