In vivo effect of adenosine on adenine nucleotides and inorganic phosphate in rat blood.
The effect of adenosine and the time response on adenine nucleotide and Pi levels in rat blood was investigated. An increase in adenine nucleotide with a concomitant decrease in Pi concentration 30, 60, and 90 minutes after the nucleoside administration were observed. Though the 100 mg/Kg dose showed the highest effect on nucleotide concentration, the maximal response on Pi content was achieved with the 50 mg/Kg dose. The results are discussed at the light of previous data obtained in hepatocytes, and using as indicators the energy charge and the phosphorylation potential.
D000227:Adenine Nucleotides / Q000097:blood*; D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects; D008297:Male; D010710:Phosphates / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000227:Adenine Nucleotides; D010710:Phosphates; D000241:Adenosine