Gene mapping within the T/t complex of the mouse. II. Anomalous position of the H-2 complex in t haplotypes.
Naturally occurring t haplotypes are chromosome 17 polymorphisms that suppress genetic recombination in t/+ heterozygotes over a long distance that includes the H-2 complex. There is strong linkage disequilibrium between t haplotypes and H-2 haplotypes; over 20 independently isolated t chromosomes representing eight different complementation groups share only four H-2 haplotypes. Thus t haplotypes and their associated H-2 loci are inherited en bloc as a "supergene" complex, whose frequency is driven in wild mouse populations by their high transmission from male t heterozygotes. This phenomenon must therefore serve as an important regulator of H-2 polymorphisms. Genes within the region of recombination suppression in t haplotypes have been mapped by crossing-over that occurs readily between two different t haplotypes situated in trans, and by this means we show here that the H-2 complex occupies an anomalous position in t haplotypes, mapping proximal to the locus of tf closely flanked by t-lethal mutations.
D000818:Animals; D002874:Chromosome Mapping; D003434:Crossing Over, Genetic; D005260:Female; D005804:Genes, Lethal; D006183:H-2 Antigens / Q000235:genetics* / Q000276:immunology; D006650:Histocompatibility Testing; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009154:Mutation; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic
D006183:H-2 Antigens