Rat muscle structure and metabolism in relation to age and food intake.
Age changes in oxygen consumption and the structural composition of the lateral omohyoideus muscle were studied in adult male rats. The rate were either fed ad libitum (group A) or 60% of the ad libitum intake (group R). An age-related loss in muscle mass did not occur even at advanced ages in group A or group R rats. Muscle fiber diameter decreased with age in both groups but a concomitant increase in the number of fibers prevented a change in muscle mass. The muscles of group R rats contained the same number of fibers as those of group A rats at all ages. The muscles of group A rats showed a progressive loss in rate of resting oxygen consumption until 18 mo of age. A similar but less marked loss in oxygen consumption occurred in the muscles of group R rats. These results provide further evidence that life-prolonging food restriction modulates physiological changes associated with the aging process.
D000375:Aging; D000818:Animals; D008297:Male; D024510:Muscle Development; D009132:Muscles / Q000502:physiology*; D009747:Nutritional Physiological Phenomena; D010101:Oxygen Consumption; D051381:Rats; D011916:Rats, Inbred F344