title: Isoetharine-isoproterenol: a comparison of effects in childhood status asthmaticus.
abstract: Eighteen children in status asthmaticus, six to 14 years of age, were systematically studied to compare the efficacy of aerosolized isoetharine and isoproterenol. The studies were conducted in a randomized, double-blind fashion. Five inhalations of 1% isoetharine and 0.5% isoproterenol were administered via a wall-mounted air/O2 nebulizing unit. Pulse, respiratory rate, blood pressure, FVC, PEFR, FEV1 and FEF25-75 were measured at the patient's bedside. Isoetharine produced significantly less cardiac side effect and tended to produce a greater improvement in pulmonary function than did isoproterenol. In addition, no change from baseline was noted in any of the parameters at 120 minutes following treatment with either medication.
mesh_terms: D000293:Adolescent; D000336:Aerosols; D000605:Amino Alcohols / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D004311:Double-Blind Method; D006801:Humans; D007528:Isoetharine / Q000008:administration & dosage / Q000627:therapeutic use*; D007545:Isoproterenol / Q000008:administration & dosage / Q000627:therapeutic use; D011674:Pulse / Q000187:drug effects; D012129:Respiratory Function Tests
chemical_list: D000336:Aerosols; D000605:Amino Alcohols; D007545:Isoproterenol; D007528:Isoetharine