Influence of sodium fluoride on isoenzyme patterns in the lung homogenates of mice with experimental influenza infection.
NaF was administered intranasally to mice- either as a single or as four daily 100-gamma doses - prior to inoculation of influenza virus A/PR8/34 (H0N1). The changes caused by drug treatment in the isoenzyme patterns of peroxidase, acid and alkaline phosphatases, succinate and lactate dehydrogenases, observed in the mouse lung homogenates, could not be correlated with the previously recorded NaF-induced reduction in hemagglutinating titers and mortality rate.
D000135:Acid Phosphatase / Q000032:analysis; D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D005459:Fluorides / Q000494:pharmacology*; D007527:Isoenzymes / Q000032:analysis*; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008168:Lung / Q000201:enzymology*; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy / Q000201:enzymology*; D010544:Peroxidases / Q000032:analysis; D012969:Sodium Fluoride / Q000494:pharmacology*
D007527:Isoenzymes; D012969:Sodium Fluoride; D007770:L-Lactate Dehydrogenase; D010544:Peroxidases; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D005459:Fluorides