Canine cutaneous lymphoma.
Cutaneous lymphoma (mycosis fungoides) was diagnosed by multiple biopsies of nonulcerated cutaneous lesions in 13 dogs. The disease was initially characterized by erythema and alopecia of the trunk. Subsequently severe scaling, pruritus, and skin nodules developed. Lymph nodes were usually normal in size during early stages of the disease but became enlarged as the disease became extensive. Four dogs were treated with cytotoxic drugs. Marked improvement of skin lesions occurred in 3 dogs, but treatment did not prevent development of extra-cutaneous lesions.
D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D005260:Female; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008466:Mechlorethamine / Q000627:therapeutic use; D009182:Mycosis Fungoides / Q000188:drug therapy / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D011239:Prednisolone / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D014750:Vincristine / Q000627:therapeutic use
D008466:Mechlorethamine; D014750:Vincristine; D003520:Cyclophosphamide; D011239:Prednisolone