Evidence for single-cell origin of 3-methylcholanthrene-induced fibrosarcomas in mice with cellular mosaicism.
Fibrosarcomas produced by s.c. injection of 5 micrograms of 3-methylcholanthrene in Pgk-1a/Pgk-1b mice carrying X-chromosome inactivation mosaicism for the phosphoglycerate kinase (PGK-1) gene contained only one type of phosphoglycerate kinase in seven of eight cases (88%), as judged from its electrophoretic mobility, indicating the single-cell origin of the tumor.
D000818:Animals; D004586:Electrophoresis; D005260:Female; D005354:Fibrosarcoma / Q000097:blood / Q000139:chemically induced* / Q000235:genetics; D008297:Male; D008748:Methylcholanthrene / Q000633:toxicity*; D051379:Mice; D009030:Mosaicism; D009368:Neoplasm Transplantation; D010641:Phenotype; D010735:Phosphoglycerate Kinase / Q000235:genetics; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000235:genetics; D014960:X Chromosome / Q000648:ultrastructure
D008748:Methylcholanthrene; D010735:Phosphoglycerate Kinase