title: Effects of trichloroethylene inhalation on acid phosphatase in rodent brain.
abstract: Rats, mice and gerbils were continuously exposed to 150 ppm trichloroethylene (TCE) for 30 days. In all three species, there was a marked increase in liver weight. In mice the weight increased more (86%) than in rats and gerbils (20%). After exposure the activity of acid phosphatase, a lysosomal marker enzyme, was tested in different brain areas, using a system which had a limit of detection of +/- 10-15%. In most areas no significant influence was found. However, in the brain stem of mice and gerbils the phosphatase activity increased by approx. 10%.
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D005260:Female; D005849:Gerbillinae; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014241:Trichloroethylene / Q000633:toxicity*
chemical_list: D014241:Trichloroethylene; D000135:Acid Phosphatase