Sulindac-induced aseptic meningitis.
A 22-year-old woman with systemic lupus erythematosus experienced generalized pruritus, shortness of breath, pleuritic chest pain, visual blurring, severe photophobia, a stiff neck, an occipital headache, and a temperature of 39.4 degrees C within one hour after taking sulindac (Clinoril). Findings from a CSF examination disclosed a notable elevation of protein and a polymorphonuclear pleocytosis. All symptoms disappeared within 24 hours. Inhibition of prostaglandin synthesis did not seem to be the mechanism of this adverse reaction, since the patient tolerated aspirin.
D000328:Adult; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D006801:Humans; D007192:Indenes / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy; D008581:Meningitis / Q000139:chemically induced*; D008582:Meningitis, Aseptic / Q000139:chemically induced*; D013467:Sulindac / Q000009:adverse effects* / Q000627:therapeutic use
D007192:Indenes; D013467:Sulindac