The effect of taurine on high potassium-and noradrenaline-induced contraction in rabbit ear artery.
1 Intraluminal administration of taurine (40 mM) did not affect the contractile tone of rabbit isolated ear artery 2 Taurine (10-80 mM) exerted a powerful concentration-dependent, vasodilator action in arteries contracted with high potassium medium. 3 In the same experimental conditions, the taurine analogues beta-alanine and homotaurine, had no effect. 4 Taurine (40-80 mM) did not affect in a significant manner the tonic component of the noradrenaline (5x10(-6 M)-induced contraction. 5 When noradrenaline (5x10(-6M) was followed by the administration of high potassium medium a further increase in intraluminal pressure was observed. Under these conditions taurine (40 mM) reversed specifically the component due to the high potassium medium.
D000409:Alanine / Q000494:pharmacology; D000818:Animals; D001158:Arteries / Q000187:drug effects; D004347:Drug Interactions; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology*; D011817:Rabbits; D013654:Taurine / Q000031:analogs & derivatives / Q000494:pharmacology*; D014700:Verapamil / Q000494:pharmacology
D013654:Taurine; C001355:tramiprosate; D014700:Verapamil; D000409:Alanine; D011188:Potassium; D009638:Norepinephrine