title: Ocular hypotensive effects of N-demethylated carbachol on open angle glaucoma.
abstract: Ocular hypotensive actions of N-demethylated carbachol hydrochloride (DMC) were studied in patients with open angle glaucoma; 1% pilocarpine hydrochloride solution was used as a reference. Although 1% pilocarpine seemed to be slightly more potent that 6% and 9% DMC solutions, DMC solutions were devoid of the noticeable side effects produced by pilocarpine. In all cases, maximum ocular hypotensive actions were observed six hours after the single-drop medication and were determined as 4.2, 4.6, and 4.8 mm Hg with 6% DMC, 9% DMC, and 1% pilocarpine, respectively.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002217:Carbachol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010862:Pilocarpine / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D010862:Pilocarpine; D002217:Carbachol; C016348:N-demethylcarbachol