[Effect of the new antidepressant cephedrine on compensatory hypertrophy of the ovaries and the inhibiting effect of estrogen].
It has been shown in experiments on female albino rats that cephedrine in doses of 20 and 50 mg/kg (per os) prevents the inhibitory action of diethylstilbestrol propionate on compensatory hypertrophy of the ovary. It has been demonstrated that on being given in a dose of 50 mg/kg the drug itself favours more pronounced compensatory hypertrophy of the ovary and exhibits activity in the area of the hypothalamo-hypophyseal centers that regulate gonadal function.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D004054:Diethylstilbestrol / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006984:Hypertrophy; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D010053:Ovary / Q000187:drug effects* / Q000473:pathology; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats
D000928:Antidepressive Agents; D011412:Propanolamines; C017118:cephedrine; D004054:Diethylstilbestrol
Vliianie novogo antidepressanta tséfedrina na kompensatornuiu gipertrofiiu iaichnika i ingibiruiushchiĭ ee éffekt éstrogena.