title: Prognostic significance of serum CRP levels and lymphoid cell infiltrates in human breast cancer.
abstract: As part of a major study to identify prognostic factors for human breast cancer we evaluated serum C-reactive protein (CRP) concentration and extent of lymphocytic infiltration of the tumor as prognostic markers. Elevated serum CRP concentrations were present in a higher proportion of patients with stage IV disease, the presence of metastasis, and the presence of leukocytic infiltration of the primary tumor. CRP levels did not correlate with the length of the disease-free interval following surgery, the histopathological grade of the tumor, or lymph node involvement. Although serum CRP levels and the presence of a lymphoid cell infiltrate correlated with each other, neither measure was a useful prognostic indicator.
mesh_terms: D001943:Breast Neoplasms / Q000097:blood* / Q000473:pathology; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D009362:Neoplasm Metastasis; D011379:Prognosis
chemical_list: D002097:C-Reactive Protein