Factors inhibiting cell proliferation in rat liver cytoplasm.
Two factors from normal rat liver cytoplasm inhibited the proliferation of cultured L-929 fibroblasts. One was arginase, the other was a small molecular weight inhibitor stable to trypsin and heat treatment. The small molecular weight inhibitor inhibited the protein and DNA synthesis of L-cells. Inhibition of DNA synthesis was thought to be secondary to the inhibition of protein synthesis.
D000818:Animals; D001119:Arginase / Q000032:analysis; D002455:Cell Division; D003593:Cytoplasm / Q000032:analysis*; D004247:DNA / Q000096:biosynthesis; D006131:Growth Inhibitors / Q000032:analysis*; D007739:L Cells; D008099:Liver / Q000166:cytology* / Q000378:metabolism; D014176:Protein Biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
D006131:Growth Inhibitors; D004247:DNA; D001119:Arginase