Sympathetic immunoregulation: difference between high- and low-responder animals.
A quantitative relationship is reported between the magnitude of the immune response of rats to sheep red blood cells and diminution of splenic norepinephrine (NE). A decrease in concentration and content of NE in the spleen on day 3 after immunization was evident in both high- and low-responder animals, whereas a diminished concentration of NE persisted only in the high responders. This continuing NE diminution in high-responder animals is associated with increase in spleen weight, probably attributable to blood accumulation. These findings are consonant with the concept that the sympathetic nervous system is involved in immunoregulation.
D000818:Animals; D000917:Antibody Formation; D004912:Erythrocytes; D005260:Female; D009638:Norepinephrine / Q000032:analysis; D009929:Organ Size; D051381:Rats; D012756:Sheep; D013154:Spleen / Q000276:immunology; D013564:Sympathetic Nervous System / Q000276:immunology*
D009638:Norepinephrine