Synthesis and local anesthetic activity of some n-beta-diethylaminoethylnaphthalimides.
Some N-beta-diethylaminoethylnaphthalimides substituted in the 3 or 3 and 4 positions with alkoxy or butylamino groups or with alkoxy and amino groups (III) have been synthesized by reaction of the appropriate naphthalic anhydride with N,N-diethylethylenediamine. Some compounds (III) were tested to evaluate their anesthetic activity: compounds (III e) and (III f) have been shown to have a greater activity than lidocaine.
D000779:Anesthetics, Local / Q000138:chemical synthesis* / Q000633:toxicity; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003315:Cornea / Q000187:drug effects; D005021:Ethylamines / Q000138:chemical synthesis / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits; D011930:Reaction Time / Q000187:drug effects; D012018:Reflex / Q000187:drug effects
D000779:Anesthetics, Local; D005021:Ethylamines; D009281:Naphthalenes