Relationship between sleep stage IV deficit and reversible HGH deficiency in psychosocial dwarfism.
Polygraphic sleep recordings were done in four children with psychosocial dwarfism. The first recordings, performed within the first days after hospitalization, exhibited a gross deficit of stage IV sleep and a decrease of the durations of slow wave sleep episodes (SWS = stage III and IV). The second recordings were performed after several wk (3-15) in the new environment, during the growth recovery period. A clear improvement of sleep quality was observed, namely an increase of stage IV amounts. In two of the four patients, hGH release was studied by means of the ornithine test. A low response was found in the first (2) days of hospitalization whereas normal response was observed during the recovery period suggesting a partial and reversible hGH deficiency. A simultaneous recovery of both stage IV sleep and the growth rate was observed in the four patients. These data suggest that sleep disturbances are strongly linked to growth failure in psychosocial dwarfism.
D002675:Child, Preschool; D004392:Dwarfism / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006128:Growth; D013006:Growth Hormone / Q000097:blood* / Q000172:deficiency; D006801:Humans; D007223:Infant; D008297:Male; D009952:Ornithine / Q000494:pharmacology; D012894:Sleep Stages / Q000502:physiology*; D013997:Time Factors
D013006:Growth Hormone; D009952:Ornithine