The levels of free cholesterol and cholesterol esters in serum before, during and after the induction of experimental allergic encephalomyelitis in the guinea-pig.
Cholesterol esters and free cholesterol were determined in the serum of guinea-pigs with experimental allergic encephalomyelitis (EAE). EAE was induced by immunization with myelin basic protein (MBP). The results showed a marked decrease in cholesterol esters (CHE) 4 days after immunization. Seven days after immunization the values of esters increased and reached a maximum during the period of manifest clinical signs of EAE. After the cessation of clinical signs, after 2 weeks, the values of esters returned to the initial or somewhat lower values. The level of cholesterol was inverse to the values of cholesterol esters. Histological analyses showed characteristic changes in the brain and spinal cord. A possible correlation between the changes in cholesterol esters and cholesterol of the brain and serum in EAE is suggested.
D000818:Animals; D002784:Cholesterol / Q000097:blood*; D002788:Cholesterol Esters / Q000097:blood*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000097:blood* / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D007114:Immunization; D008297:Male; D013997:Time Factors
D002788:Cholesterol Esters; D002784:Cholesterol