Preparation of 186Re-perrhenate for nuclear medical purposes.
The preparation of 186Re perrhenic acid from metallic rhenium-186 is achieved by the oxidation of 186Re with H2O2. Neutralization with aqueous ammonia and evaporation of the solvent yielded pure NH4 186ReO4. As an example of its applicability to nuclear medicine the 186Re-MDP complex was formed by the tin-reduction method and tested for its bone affinity in rabbits. The 186Re-MDP complex formation proved to be pH dependent, with almost no 186Re-MDP complex being formed at neutral pH whereas 92.6% of the nuclide was complexed to MDP at pH 1.4 indicating the necessity for a sufficiently low pH for rapid 186Re-complex formation.
D000005:Abdomen / Q000000981:diagnostic imaging; D000818:Animals; D004164:Diphosphonates; D007553:Isotope Labeling / Q000379:methods*; D010388:Pelvis / Q000000981:diagnostic imaging; D011817:Rabbits; D011868:Radioisotopes; D011877:Radionuclide Imaging; D012211:Rhenium
D004164:Diphosphonates; D011868:Radioisotopes; C015428:perrhenate; C027474:methylene diphosphonate; D012211:Rhenium