title: Novel mode of contraception using polymeric hydrogels. I.
abstract: A new method of fertility control has been proposed and tested. The technique involves the use of the polymer, which when injected into the vas deferens lowers the pH sufficiently so as to kill the spermatozoa passing through. The polymer provides an acidic environment for a prolonged time and slowly erodes. The fertility may be restored after complete solubility of the polymer itself over a period of time or by flushing it with a suitable solvent. This method of male contraception is nonsurgical, nonocclusive, and reversible.
mesh_terms: D003267:Contraception / Q000379:methods*; D003272:Contraceptive Agents, Male / Q000008:administration & dosage*; D005298:Fertility / Q000187:drug effects; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D006863:Hydrogen-Ion Concentration; D007267:Injections; D008297:Male; D008689:Methacrylates; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D011109:Polymethacrylic Acids; D013094:Spermatozoa / Q000187:drug effects* / Q000502:physiology; D014649:Vas Deferens
chemical_list: D003272:Contraceptive Agents, Male; D008689:Methacrylates; D011109:Polymethacrylic Acids; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; C005044:hydroxyethyl methacrylate