Intraocular penetration of rosoxacin in rabbits.
Rosoxacin, a new synthetic antimicrobial agent, has a wide spectrum of activity that may prove beneficial in the treatment of ocular infections. To determine the penetration of rosoxacin into ocular tissues and serum of the rabbit after topical, subconjunctival, and intravenous (IV) administration, rosoxacin levels were measured using a microbiological assay after enzymatic digestion of the ocular tissues. Quantities of rosoxacin that should prove to be of therapeutic value were detectable in the anterior segment of the eye after topical or subconjunctival administration. Subconjunctival administration also resulted in high levels in the retina and choroid area and in the optic nerve. Low levels were detected in the retina and choroid 15 minutes following IV injection; however, no detectable levels were found in the ocular tissues after this period.
D042462:4-Quinolones; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002829:Choroid / Q000032:analysis; D003228:Conjunctiva; D005123:Eye / Q000032:analysis / Q000187:drug effects*; D005260:Female; D007267:Injections; D007275:Injections, Intravenous; D009900:Optic Nerve / Q000032:analysis; D010539:Permeability; D011804:Quinolines / Q000032:analysis / Q000494:pharmacology*; D015363:Quinolones; D011817:Rabbits; D012160:Retina / Q000032:analysis
D042462:4-Quinolones; D000890:Anti-Infective Agents; D011804:Quinolines; D015363:Quinolones; C021083:rosoxacin