Anticonvulsant action of excitatory amino acid antagonists.
Compounds that antagonize neuronal excitation induced by dicarboxylic amino acids were tested in two animal models of epilepsy, namely sound-induced seizures in DBA/2 mice and threshold pentylenetetrazol seizures in Swiss mice. Sound-induced seizures could be prevented by intracerebroventricular injection of compounds that block excitation due to N-methyl-D-aspartic acid. The most potent such compound, 2-amino-7-phosphonoheptanoic acid, was anticonvulsant in both test systems when given either intraperitoneally or intracerebroventricularly. Specific antagonists of excitation that is caused by amino acids provide a new class of anticonvulsant agents.
D000600:Amino Acids, Dicarboxylic / Q000037:antagonists & inhibitors*; D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants; D004195:Disease Models, Animal; D018691:Excitatory Amino Acid Antagonists; D005971:Glutamates / Q000494:pharmacology; D051379:Mice; D008811:Mice, Inbred DBA; D009943:Organophosphorus Compounds / Q000494:pharmacology*
D000600:Amino Acids, Dicarboxylic; D000613:Aminobutyrates; D000927:Anticonvulsants; D018691:Excitatory Amino Acid Antagonists; D005971:Glutamates; D009943:Organophosphorus Compounds; C011829:glutamic acid diethyl ester