[adenylate cyclase system in Ehrlich ascites tumor cells sensitive and resistant to 5-fluorouracil].
It is established that the adenylate cyclase activity in cells of the tumour strain resistant to 5-fluorouracil was higher and that of 3':5' AMP phosphodiesterase was lower as compared to the activity of these enzymes in cells of the tumor strain sensitive to the preparation. The cyclic AMP level in the resistant to 5-FU tumour cells was considerably higher than in cells of the sensitive tumour strain.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000201:enzymology*; D004351:Drug Resistance; D005472:Fluorouracil / Q000627:therapeutic use*; D051379:Mice
D000262:Adenylyl Cyclases; D005472:Fluorouracil
Adenilattsiklaznaia sistema v opukholevykh kletkakh chuvstvitel'nogo i ustoĭchivogo k 5-ftoruratsilu shtammov astsitnoĭ kartsinomy Erlikha.