title: Enzymatic chemical modification of human amniotic membrane and skin as a means for the preparation of biological dressing.
abstract: A non-antigenic biological dressing of amniotic membrane and skin was prepared by treatment with the enzyme ficin and dialdehyde starch. The dressing was tested in experimental animals for the coverage of full-thickness skin defects. The healing process was studied, as well as the durability of the biological dressing. Testing for flexibility, adherence and antigenicity, there was no change in the ficin-treated dressing when used even after being stored for a period of up to 2 years. The enzyme treatment did not result in a superior biological dressing.
mesh_terms: D000650:Amnion / Q000201:enzymology*; D000818:Animals; D001458:Bandages; D001684:Biological Dressings; D062109:Dermatologic Surgical Procedures; D005361:Ficain / Q000494:pharmacology; D006801:Humans; D008297:Male; D051379:Mice; D012867:Skin / Q000187:drug effects / Q000201:enzymology*; D014182:Transplantation, Autologous
chemical_list: D005361:Ficain