Thyroparathyroidectomy increases the activity of catalase in the adrenal gland of the rat. A structural and functional study.
At four weeks after thyroparathyroidectomy the activity of catalase in adrenal homogenates was significantly greater (2.95 +/- 0.06 mumoles 0(2)/min/mg protein) than that of controls (2.17 +/- 0.09 mumoles 0(2)/min/mg protein). Increased activity of catalase is related directly to more numerous peroxisomes in cortical cells in the zona fasciculata-zona reticularis of thyroparathyroidectomized rats. The absolute and relative volumes of adrenal gland and zona fasciculata were reduced significantly which is directly correlated with increased peroxisomal activity. A hormonally mediated mechanism reflecting alteration in ACTH, growth hormones and thyroid hormones may mediate adrenocortical atrophy and in turn increase in activity of catalase.
D000311:Adrenal Glands / Q000201:enzymology* / Q000648:ultrastructure; D000313:Adrenal Medulla / Q000201:enzymology; D000818:Animals; D002374:Catalase / Q000378:metabolism*; D005260:Female; D006651:Histocytochemistry; D010280:Parathyroid Glands / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013965:Thyroidectomy
D002374:Catalase