Variations in the metabolism and maturation of collagen after fluoride ingestion.
This study describes the effect of fluoride ingestion (10 mg NaF/kg body weight per day) for up to 180 days, on the biosynthesis, maturation and degradation of rabbit skin collagen. Higher intake of fluoride interferes with the collagen biosynthesis resulting in a reduction in the collagen content (in terms of hydroxyproline). Fluoride administration increases the solubility of collagen by reducing the amounts of cross-link precursors, thus impairing the cross-linking and maturation of tissue collagen fibers. Collagen degradation by the collagen-bound collagenase is increased due to the accumulation of higher pools of soluble collagen.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D005459:Fluorides / Q000378:metabolism / Q000494:pharmacology*; D006909:Hydroxyproline / Q000032:analysis; D011392:Proline / Q000032:analysis; D011817:Rabbits; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D012969:Sodium Fluoride / Q000494:pharmacology*; D012995:Solubility
D012969:Sodium Fluoride; D003094:Collagen; D011392:Proline; D005459:Fluorides; D006909:Hydroxyproline