title: [Therapy of acute diseases of the upper airway. Comparison of 2 antiseptic pharyngeal sprays in otorhinolaryngologic practice].
abstract: 100 out-patients with subacute or acute stages of pharyngitis, tonsillitis, pharyngotonsillitis or angina participated in a randomized 3 day trial on antiseptic mouth-sprays comparing one containing a combination of chlorhexidine, tramazoline and aluminiumtrilactate with one containing only hexetidine. At the beginning of therapy and 3 days afterwards the local symptoms rubor and tumefaction of the throat, dysphagia, fur, swelling and tenderness of the cervical superficial lymph nodes were classified according to a graded scale. Using the combination these symptoms were markedly improved in 34 patients, improved in 7; 8 showed no alteration and one patient showed a deterioration (n = 50). With the monosubstance 18 patients showed good improvement, 11 an improvement, 17 no change and 3 patients a deterioration (n = 49), one patient needed penicillin-treatment during the trial. Under treatment with the combination the symptoms rubor and tumefaction of the throat showed a significant better improvement. The possible role played by a vasodilator are discussed.
mesh_terms: D000336:Aerosols; D000891:Anti-Infective Agents, Local / Q000009:adverse effects; D002710:Chlorhexidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004338:Drug Combinations / Q000009:adverse effects / Q000627:therapeutic use; D004341:Drug Evaluation; D006590:Hexetidine / Q000627:therapeutic use*; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects / Q000627:therapeutic use*; D007773:Lactates / Q000009:adverse effects / Q000627:therapeutic use*; D010038:Otorhinolaryngologic Diseases / Q000188:drug therapy*; D010614:Pharynx; D012141:Respiratory Tract Infections / Q000188:drug therapy*
chemical_list: D000336:Aerosols; D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D007093:Imidazoles; D007773:Lactates; C034255:lurgyl; D006590:Hexetidine; D002710:Chlorhexidine
vernacular_title: Therapie akuter Erkrankungen der oberen Atemwege. Therapievergleich zweier antiseptischer Rachen-Sprays in der HNO-Praxis.