Serologically defined antigens on the surface of somatic hybrid cells.
Y2C somatic cell hybrids, which immunize semiallogeneic mice and protect them against further challenge with syngeneic malignant cells, express normal H-2 antigens from parental cells and, in addition, the L antigen and the Friend, Moloney, Rauscher type-specific antigen. This was demonstrated by immunoabsorption, complement-dependent cytotoxicity and immunofluorescence experiments.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005260:Female; D005622:Friend murine leukemia virus / Q000276:immunology; D006183:H-2 Antigens / Q000276:immunology; D006822:Hybrid Cells / Q000276:immunology*; D007106:Immune Sera / Q000276:immunology; D007114:Immunization; D007939:Leukemia L1210 / Q000276:immunology; D007942:Leukemia, Experimental / Q000276:immunology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA; D008979:Moloney murine leukemia virus / Q000276:immunology; D011925:Rauscher Virus / Q000276:immunology; D013154:Spleen / Q000378:metabolism
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D006183:H-2 Antigens; D007106:Immune Sera