Development of serotonin-mediated behavioral inhibition in the hyperthyroid mouse.
Experimental hyperthyroidism was induced in neonatal mice by thyroxine injections at 1-3 days of age. Control and thyroxine-treated mice were subsequently tested daily for locomotor activity following injections of methysergide, a serotonin antagonist, or saline from 10 through 15 days of age. Although thyroxine-treated mice were more active than controls, the ontogeny of methysergide-induced disinhibition of locomotor activity was similar for both thyroxine-treated and control mice. The results suggest that the early maturation of serotonin-mediated inhibition of behavioral arousal is not affected by thyroxine-accelerated development. Results are discussed in terms of the specificity of the pharmacological agent, methysergide.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology*; D006980:Hyperthyroidism / Q000523:psychology*; D008784:Methysergide / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D012701:Serotonin / Q000502:physiology*; D013974:Thyroxine / Q000494:pharmacology
D012701:Serotonin; D013974:Thyroxine; D008784:Methysergide