[Experimental study of optimal dose interval in antibiotic therapy].
A postantibiotic effect (PAE) was demonstrated for various antibiotics which suppressed bacterial regrowth for at least two hours beyond the termination of a short drug exposure in vitro. Rifampin, tetracycline and erythromycin already exhibit a PAE at low concentrations. In contrast, in the case of beta-lactams high concentrations - higher than those obtained in serum during oral treatment - were needed to demonstrate a PAE of these antibiotics in vitro. The PAE phenomenon may be of clinical importance with regard to dosage regimens in antimicrobial chemotherapy.
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004917:Erythromycin / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013752:Tetracycline / Q000494:pharmacology; D013997:Time Factors
D000900:Anti-Bacterial Agents; D010406:Penicillins; D004917:Erythromycin; D013752:Tetracycline; D012293:Rifampin
Experimentelle Studien zur Frage des optimalen Dosisintervalls in der Antibiotikatherapie.