Bromide space, total body water, and sick cell syndrome.
Displacements of the bromide space (Br-82-C, as a marker for the extracellular fluid compartment) are caused by an enhanced anatomical space and/or increased permeability of cells to bromide. The ratio Br-82-C: total body water (TBW) was evaluated to be 0.83 +/- 0.17 in critically ill patients (n = 38) compared with the normal value of 0.46 +/- 0.04 (n = 10). Because of normal TBW in critically ill patients (TBW = 505 +/- 68 ml/kg), an increased bromide penetration into cells seems to be responsible for the enlarged ratio Br-82-C: TBW. Taking into consideration measurements in patients with malabsorption (BR-82-C: TBW = 0.56 +/- 0.13; n = 13) and carcinoma of the rectum and colon (Br-82-C: TBW = 0.66 +/- 0.24; n = 18) we think that the bromide space is a good measurement of the effective extracellular water.
D000328:Adult; D000368:Aged; D001825:Body Fluid Compartments; D001826:Body Fluids; D001834:Body Water / Q000378:metabolism*; D001965:Bromides / Q000378:metabolism*; D001966:Bromine; D002463:Cell Membrane Permeability; D005110:Extracellular Space / Q000378:metabolism; D006801:Humans; D007010:Hyponatremia / Q000209:etiology; D008875:Middle Aged; D011868:Radioisotopes; D013577:Syndrome
D001965:Bromides; D011868:Radioisotopes; D001966:Bromine