Effect of different kinds of premedication on the induction properties of midazolam.
The effects of different premedication (i.m. and i.v.) on the usefulness of midazolam or thiopentone as induction agents for minor surgery was studied in 194 women undergoing either dilatation and curettage or explorative fractionate curettage. Midazolam appeared to produce light sedation which required powerful premedication (i.m. atropine + pethidine and i.v. fentanyl or fentanyl + dehydrobenzperidol) when used as an induction agent for minor surgery. The clinically useful dose of midazolam is about 0.30 mg kg-1 i.v. There was greater variability in onset and duration of action among patients receiving midazolam than among those receiving thiopentone. Midazolam caused less respiratory depression, but there were no clinically significant differences between midazolam and thiopentone with respect to cardiovascular variables. Muscular movements were found more often, and postoperative sedation lasted longer in patients receiving midazolam. Midazolam as an induction agent appears more suited for major than for minor surgery.
D000328:Adult; D000777:Anesthetics / Q000494:pharmacology; D001569:Benzodiazepines / Q000494:pharmacology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008874:Midazolam; D011229:Preanesthetic Medication; D012119:Respiration / Q000187:drug effects; D013874:Thiopental / Q000494:pharmacology
D000777:Anesthetics; D001569:Benzodiazepines; D013874:Thiopental; D008874:Midazolam