Kupffer cells recognize trinitrobenzene-labeled erythrocytes.
Chemical-modified erythrocytes (trinitrobenzene-modified erythrocytes (TNB-RBC)) are trapped in vivo rapidly by liver macrophages (Kupffer cells). The liver homing of TNB-RBC is dependent on the concentration of TNB-residues coupled to the surface of RBC. High concentrations induce liver homing, low concentrations spleen homing.
D000818:Animals; D004912:Erythrocytes / Q000187:drug effects / Q000276:immunology*; D006241:Haptens / Q000276:immunology; D007700:Kinetics; D007728:Kupffer Cells / Q000276:immunology*; D009578:Nitrobenzenes / Q000494:pharmacology*; D010587:Phagocytosis; D051381:Rats; D013154:Spleen / Q000378:metabolism; D014301:Trinitrobenzenes / Q000494:pharmacology*
D006241:Haptens; D009578:Nitrobenzenes; D014301:Trinitrobenzenes