Adolescence, a critical stage for the genesis of female cancers (review).
Epidemiologic and hormonal aspects of cervical cancer were compared with those of breast cancer in order to explore the genesis of female cancers. When accessed by the urinary steroid analysis, cervical cancer was associated with such steroidal deviations as to reflect an arrest of adrenal maturation. Breast cancer was associated with hypercorticoidism and ovulation failure. Evidence was presented to indicate that the geneses of these 2 female cancers were each related to 2 specific disorders of adolescence (imbalances of adrenal-ovarian maturation) which were to be conditioned each by 2 specified combinations of climate, diet and marital life.
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000378:metabolism; D000367:Age Factors; D000728:Androgens / Q000378:metabolism; D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism; D004032:Diet; D005260:Female; D006801:Humans; D007564:Japan; D008393:Marriage; D012306:Risk; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism
D000305:Adrenal Cortex Hormones; D000728:Androgens