IgA nephropathy associated with seronegative spondylarthropathies.
Three patients with a seronegative spondylarthropathy were found to have IgA nephropathy. Two patients had ankylosing spondylitis (one with psoriasis), and one had incomplete Reiter's syndrome. All three had a focal proliferative glomerulonephritis with IgA-dominant mesangial immune deposits. One patient had a leukocytoclastic vasculitis. This association of IgA nephropathy with seronegative spondylarthropathies raises the possibility of a common or related pathogenesis. There is evidence to suggest that both diseases are mediated by genetically controlled immune responses to mucosal contact with etiologic antigens.
D000328:Adult; D016918:Arthritis, Reactive / Q000150:complications* / Q000235:genetics; D005921:Glomerulonephritis / Q000150:complications* / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000150:complications / Q000235:genetics; D013167:Spondylitis, Ankylosing / Q000150:complications* / Q000235:genetics; D015009:Yersinia Infections / Q000150:complications
D006680:HLA Antigens; D007070:Immunoglobulin A