title: Estimation of systolic time intervals and timing of arterial sounds in hyperthyroidism during antithyroid medication.
abstract: During antithyroid drug therapy hyperthyroid patients with border-line elevated serum T3 had shortening of pre-ejection period (PEP) and QKd interval (period between the onset of QRS complex and the onset of the Korotkoff arterial sound). There was a significant relationship between PEP and QKd interval with serum T3 concentration in a group of patients under medical therapy; PEP and QKd were normalized later than serum thyroid hormone concentration in such patients. Propranolol induced a prolongation of PEP and QKd interval in hyperthyroid patients. PEP and QKd are sensitive measures of metabolic status in thyrotoxic patients during antithyroid treatment.
mesh_terms: D006326:Heart Auscultation; D006347:Heart Sounds; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy* / Q000503:physiopathology; D008713:Methimazole / Q000627:therapeutic use*; D009200:Myocardial Contraction / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology; D013599:Systole / Q000187:drug effects*; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D008713:Methimazole; D011433:Propranolol; D013974:Thyroxine