[Pharmacokinetic characteristics of trimecaine compared to lidocaine in myocardial infarct patients].
The authors studied pharmacokinetics of trimecain and lidocain in 10 and 15 patients with myocardial infarction, respectively, after a single intravenous jet injection in the dose of 80 mg. The groups were comparable as to age, mass and surface of the body. In all patients the dependence of trimecain and lidocain concentrations on time was biexponential. Average individual values of distribution volumes in stationary condition and in the stage of elimination, clearance and half-life differed but insignificantly for trimecain and lidocain. The results obtained justify the conclusion that trimecain and lidocain are identical from the pharmacokinetic point of view.
D000083:Acetanilides / Q000097:blood*; D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000097:blood*; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008012:Lidocaine / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D013997:Time Factors; D014288:Trimecaine / Q000097:blood*
D000083:Acetanilides; D000889:Anti-Arrhythmia Agents; D008012:Lidocaine; D014288:Trimecaine
Farmakokineticheskie kharakteristiki trimekaina v sravnenii s lidokainom u bol'nykh infarktom miokarda.