Inhibition of the incorporation of 14C-precursors in Mycobacterium smegmatis by antibiotics and chemotherapeutics.
Twenty antituberculostatics and twelve other compounds were divided into three groups according to their ability to influence the rate of incorporation of 14C-adenine and 14C-leucine in M. smegmatis. The first group includes compounds significantly inhibiting the incorporation of 14C-leucine, the second group comprises compounds inhibiting simultaneously the incorporation of both 14C-precursors, the third group contains compounds that do not bring about a 50% decrease of the rate of incorporation even at a concentration of 400 micrograms/mL.
D000225:Adenine / Q000378:metabolism; D000904:Antibiotics, Antitubercular / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D002250:Carbon Radioisotopes; D003470:Culture Media; D007930:Leucine / Q000378:metabolism; D009161:Mycobacterium / Q000187:drug effects* / Q000378:metabolism
D000904:Antibiotics, Antitubercular; D000995:Antitubercular Agents; D002250:Carbon Radioisotopes; D003470:Culture Media; D007930:Leucine; D000225:Adenine