Effects of intramuscular depot-corticosteroid on the nasal mucosa in allergic rhinitis.
Effects of a single intramuscular depot-corticosteroid in allergic rhinitis were studied at clinical and light microscopic levels in Saudi personnel with allergic rhinitis. Clinical studies and biopsies were performed before and after treatment. Following a single intramuscular injection of Depo-Medrol all patients experienced relief and remained symptom-free thereafter for several months. The roentgenographic appearance of the sinuses, eosinophilia of blood and nasal secretion, skin reactivity and the microscopic features exhibited improvement. These findings suggest that a single intramuscular injection of Depo-Medrol is a satisfactory agent for the treatment of allergic rhinitis.
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D003692:Delayed-Action Preparations; D004804:Eosinophils; D006801:Humans; D007273:Injections, Intramuscular; D008775:Methylprednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077555:Methylprednisolone Acetate; D009297:Nasal Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D009298:Nasal Polyps / Q000188:drug therapy; D012221:Rhinitis, Allergic, Perennial / Q000097:blood / Q000188:drug therapy* / Q000473:pathology
D000305:Adrenal Cortex Hormones; D003692:Delayed-Action Preparations; D000077555:Methylprednisolone Acetate; D008775:Methylprednisolone