title: Chelate compounds as components of acellular, oxygen-delivering, resuscitation fluids.
abstract: The feasibility of various metal chelates as components of acellular resuscitation fluids is examined, with particular emphasis on the bonding mode and kinetics of the dioxygen adduct formed. End-on (Pauling type) or bridged peroxo-dimer structures using iron(II) or cobalt(II) as the active metal ion are currently the most promising candidates for investigation. Criteria which must be met in order to confer desirable O2-binding properties upon the coordinated metal ions are described and ligand systems (porphyrins, Schiff-bases, lacunar macrobicycles) which help fulfill these criteria are critiqued. An important aspect of acellular O2-delivering systems is the mode of dispersion, which in turn is a function of the properties of the metal chelate; this question is broached, for general application, in terms of true solutions, emulsions and colloidally suspended solids.
mesh_terms: D000818:Animals; D001692:Biological Transport; D001802:Blood Substitutes / Q000627:therapeutic use*; D002614:Chelating Agents / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D003035:Cobalt / Q000378:metabolism; D007700:Kinetics; D008968:Molecular Conformation; D010100:Oxygen / Q000378:metabolism; D011166:Porphyrins / Q000378:metabolism; D012545:Schiff Bases
chemical_list: D001802:Blood Substitutes; D002614:Chelating Agents; D011166:Porphyrins; D012545:Schiff Bases; D003035:Cobalt; D010100:Oxygen