Reduction of gentamicin bioassay values in sera with elevated inorganic phosphorus, uric acid, creatinine, and alkaline phosphatase levels.
Gentamicin was added to 45 normal and abnormal patient sera samples, which were then quantitated by bioassay and fluorescent immunoassay. Bioassay results were dramatically reduced in more than half of the sera with elevated inorganic phosphorous, uric acid, creatinine, and alkaline phosphatase values when compared with the results for fluorescent immunoassay. Erroneous bioassay results could lead to patient toxicity.
D000469:Alkaline Phosphatase / Q000097:blood; D001681:Biological Assay; D003404:Creatinine / Q000097:blood; D005839:Gentamicins / Q000097:blood*; D006801:Humans; D007118:Immunoassay / Q000379:methods; D010758:Phosphorus / Q000097:blood; D014527:Uric Acid / Q000097:blood
D005839:Gentamicins; D014527:Uric Acid; D010758:Phosphorus; D003404:Creatinine; D000469:Alkaline Phosphatase