Effect of n-octane and n-nonane administration on alkaline phosphatase activity in tissues of female rats.
Studies on alkaline phosphatase were conducted in albino rats exposed to n-octane or n-nonane for 2 and 7 days; there was an increase in alkaline phosphatase activity of liver, spleen and bone marrow. Increase in spleen alkaline phosphatase activity persisted up to 42 days after single dose of n-octane or n-nonane. Pretreatment with protein synthesis inhibitors, cycloheximide or ethionine removed this observed increase of alkaline phosphatase activity in liver and spleen.
D000469:Alkaline Phosphatase / Q000378:metabolism*; D000473:Alkanes / Q000494:pharmacology*; D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology; D005001:Ethionine / Q000494:pharmacology; D005260:Female; D008099:Liver / Q000201:enzymology; D009795:Octanes / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D013154:Spleen / Q000201:enzymology; D013997:Time Factors; D014018:Tissue Distribution
D000473:Alkanes; D009795:Octanes; D011506:Proteins; D003513:Cycloheximide; D000469:Alkaline Phosphatase; C017573:nonane; D005001:Ethionine; C026728:octane