Ion chromatographic determination of the principal inorganic ion in bulk antibiotic salts.
Two ion-chromatographic procedures were developed for determining the principal inorganic ions in bulk antibiotic salts. The anion system enables sulfate determination in sulfate salts of polymyxin, neomycin, streptomycin, and dihydrostreptomycin, with typical analysis times of 8 min/sample and a relative precision of +/- 2% (95% confidence interval). The cation system is applicable to sodium or potassium analysis in the respective penicillin salts in 9--16 min with a relative precision of +/- 2.5%. These methods offer speed, specificity, and easy sample preparation compared with traditional assays.
D000838:Anions / Q000032:analysis; D000900:Anti-Bacterial Agents / Q000032:analysis*; D002228:Carbenicillin / Q000032:analysis; D002412:Cations / Q000032:analysis; D002845:Chromatography / Q000379:methods; D007477:Ions / Q000032:analysis*; D010406:Penicillins / Q000032:analysis; D013431:Sulfates / Q000032:analysis
D000838:Anions; D000900:Anti-Bacterial Agents; D002412:Cations; D007477:Ions; D010406:Penicillins; D013431:Sulfates; D002228:Carbenicillin