title: The biocompatibility of polypyrrolidone in test implantation.
abstract: The biological compatibility of polypyrrolidone was investigated using subcutaneous implantation in rats. Acute (10 days) and chronic (360 days after implantation) tissue reaction was characterized numerically and compared with poly(2-hydroxyethyl methacrylate), used in the Drug Control Research Institute in Prague as a standard in the evaluation of polymers, for which good tolerance in the clinical practice has been demonstrated. Surface changes in the polymer were evaluated by using a scanning electron microscope.
mesh_terms: D000818:Animals; D003238:Connective Tissue / Q000648:ultrastructure; D005069:Evaluation Studies as Topic; D008297:Male; D008855:Microscopy, Electron, Scanning; D019736:Prostheses and Implants; D011760:Pyrrolidinones; D051381:Rats; D013997:Time Factors
chemical_list: D011760:Pyrrolidinones