The mesolimbic dopamine system: evidence for a high amine turnover and for a heterogeneity of the dopamine neuron population.
By means of a new photographic method to quantitate catecholamine fluorescence in tissue sections it has been possible to demonstrate a high dopamine (DA) turnover within the DA cell bodies of the midbrain. The medially located small-sized DA cell bodies of the A10 DA cell group has a very high DA turnover which was significantly different from that found in the laterally located medium-sized DA cell bodies of the A10 cell group. Thus, the mesolimbic DA pathways may be divided into two systems, the medial system having a very high DA turnover in their cell bodies which may reflect a high functional activity in this system.
D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D007700:Kinetics; D008032:Limbic System / Q000378:metabolism*; D008297:Male; D008636:Mesencephalon / Q000378:metabolism*; D008781:Methyltyrosines / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D008781:Methyltyrosines; C022260:alpha-methyltyrosine methyl ester; D004298:Dopamine