Effect of carboxylic acids on permeation of chlorpromazine through dimethyl polysiloxane membrane.
The effect of carboxylic acids on the permeation of chlorpromazine was investigated through a dimethyl polysiloxane nonpolar membrane. The permeability of the diffusate, at pH 5.8, increases considerably in the presence of carboxylic acids or phosphate, probably due to an ion-pair formation between  the relative anions and chlorpromazine.
D002264:Carboxylic Acids; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002746:Chlorpromazine; D004058:Diffusion; D004129:Dimethylpolysiloxanes; D006863:Hydrogen-Ion Concentration; D008567:Membranes, Artificial; D008823:Micelles; D010710:Phosphates; D012828:Silicones
D002264:Carboxylic Acids; D004129:Dimethylpolysiloxanes; D008567:Membranes, Artificial; D008823:Micelles; D010710:Phosphates; D012828:Silicones; D002746:Chlorpromazine