The effect of chromium on cholesterol-induced atherosclerosis in rabbits.
Rabbits fed on a 1% cholesterol diet for 30 days were injected daily with potassium chromate for a further 60 days. A 50% reduction in aortic intimal plaque area and in aortic total cholesterol content was observed. Control rabbits treated with chromium showed a significant increase in the chromium concentration of their aortas, liver and kidneys but not of the myocardium. Cholesterol-fed rabbits treated with chromium showed a significant increase in chromium concentrations in the liver and kidneys only. Serum cholesterol levels were consistently lower in the chromium-treated animals, although the differences did not reach significant levels.
D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000209:etiology; D002784:Cholesterol / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D002840:Chromates / Q000627:therapeutic use*; D004036:Diet, Atherogenic; D008297:Male; D009206:Myocardium / Q000378:metabolism; D017680:Potassium Compounds; D011817:Rabbits
D002791:Cholesterol, Dietary; D002840:Chromates; D017680:Potassium Compounds; C027373:potassium chromate(VI); D002784:Cholesterol