Tritiated imipramine binding sites are decreased in the frontal cortex of suicides.
Binding characteristics of tritiated imipramine were determined in the frontal cortex of suicides and well-matched controls. Maximal binding was significantly lower in brains from the suicides. This finding is consistent with reports of decreased tritiated imipramine binding in the platelets of patients diagnosed as having a major affective disorder.
D000293:Adolescent; D000328:Adult; D002352:Carrier Proteins; D002540:Cerebral Cortex / Q000378:metabolism*; D006801:Humans; D007099:Imipramine / Q000378:metabolism*; D007700:Kinetics; D008875:Middle Aged; D011955:Receptors, Drug / Q000378:metabolism*; D012016:Reference Values; D013405:Suicide; D014316:Tritium
D002352:Carrier Proteins; D011955:Receptors, Drug; C027775:imipramine receptor; D014316:Tritium; D007099:Imipramine