Combined water-soluble carriers for coprecipitates of tolbutamide.
A study was conducted on the influence of single and combined carriers on the dissolution rate of tolbutamide from its coprecipitates. All of the water-soluble carriers investigated enhanced the dissolution rate of tolbutamide, but the combination of 40% polyethylene glycol 6000--60% dextrose as the carrier for a 1:1 coprecipitate yielded the most rapid dissolution of tolbutamide. Other carriers used were polyethylene glycol 6000, polyethylene glycol 4000, dextrose, and mannitol, alone or combined in various proportions.
D011232:Chemical Precipitation; D014677:Pharmaceutical Vehicles; D011092:Polyethylene Glycols; D012995:Solubility; D014044:Tolbutamide
D014677:Pharmaceutical Vehicles; D011092:Polyethylene Glycols; D014044:Tolbutamide