title: Early discontinuation of anticonvulsants after neonatal seizures: a preliminary report.
abstract: Seizures in the neonatal period generally respond well to anticonvulsant therapy, but exposure to anticonvulsant medication during the first few months of life may have a detrimental influence on growth and development. The optimal length of therapy is not known, though there are indications that treatment can be discontinued shortly after seizure control. We report a protocol in which anticonvulsant agents are discontinued before discharge from our neonatal unit. Follow-up of these infants has shown no recurrence of seizures.
mesh_terms: D002657:Child Development / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006128:Growth / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy*; D007363:Intensive Care Units, Neonatal; D008297:Male; D010634:Phenobarbital / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012640:Seizures / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D010634:Phenobarbital