The role if dopamine and norepinephrine uptake inhibition in mediating the central effects of d-amphetamine in vivo.
Male Sprague-Dawley rats were injected with 1.5 mg/kg d-amphetamine and later sacrificed at a time when the locomotor activity induced by this dose of d-amphetamine was maximal (60 minutes post injection). Subsequently, both cortical and striatal slices were measured for 3H-DA and 3H-NE uptake. It was found that in vivo, d-amphetamine does not preferentially inhibit the reuptake of DA or NE in either the striatum or cerebral cortex, suggesting that any selective effect on a specific catecholamine must result from a mechanism other than selective uptake inhibition.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D003913:Dextroamphetamine; D004298:Dopamine; D009638:Norepinephrine