Tamm-Horsfall mucoproteins promote calcium oxalate crystal formation in urine: quantitative studies.
The technique of rapid evaporation of whole urine to standard osmolality has been studied further and quantitative measurements made of the calcium oxalate crystals resulting, firstly by a microscope method and secondly by isotope method using 14C-oxalate. It is confirmed that ultrafiltration of urine prior to evaporation leads to a large reduction in calcium oxalate crystal formation and that this is largely restored by addition of human urinary Tamm-Horsfall protein (uromucoid). Albumin does not have this effect.
D000418:Albumins / Q000494:pharmacology; D002129:Calcium Oxalate / Q000652:urine*; D002250:Carbon Radioisotopes; D003460:Crystallization; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008970:Molecular Weight; D009088:Mucoproteins / Q000494:pharmacology*; D009994:Osmolar Concentration; D010070:Oxalates; D019815:Oxalic Acid; D014462:Ultrafiltration; D058949:Uromodulin
D000418:Albumins; D002250:Carbon Radioisotopes; D009088:Mucoproteins; D010070:Oxalates; C548612:UMOD protein, human; D058949:Uromodulin; D002129:Calcium Oxalate; D019815:Oxalic Acid