A trial comparing cefaclor with co-trimoxazole in the treatment of acute otitis media.
A prospective random double-blind controlled trial comparing the efficacy of cefaclor with that of co-trimoxazole in the treatment of otitis media was undertaken. Two hundred and twenty-three children aged 12 years or younger were studied. Both drugs were effective, with clinical cure or improvement in more than 90% of the children. The level of compliance was high and side effects few. Both co-trimoxazole and cefaclor can be considered safe and effective drugs for the treatment of acute otitis media.
D002433:Cefaclor / Q000627:therapeutic use*; D002506:Cephalexin / Q000031:analogs & derivatives*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations; D006801:Humans; D007223:Infant; D010033:Otitis Media / Q000188:drug therapy*; D011897:Random Allocation; D013420:Sulfamethoxazole / Q000627:therapeutic use*; D014295:Trimethoprim / Q000627:therapeutic use*
D004338:Drug Combinations; D002433:Cefaclor; D014295:Trimethoprim; D013420:Sulfamethoxazole; D002506:Cephalexin