title: Increased specific binding of angiotensin II in the organum vasculosum of the laminae terminalis area of the spontaneously hypertensive rat brain.
abstract: Three localized sites, the organum vasculosum, lamina terminalis (OVLT) subfornical organ (SFO) and cortex in the brains of spontaneously hypertensive (SH) rats and normotensive Wistar-Kyoto (WKY) rats were micro-dissected out. The membranes were assayed for 125I-labelled angiotensin II specific binding. The only significant difference was a 129% greater specific binding in the OVLT in SH compared to WKY rats. Specific binding of 125I-labelled angiotensin II in the SFO and the cerebral cortex was not significantly different between the two strains. SH rats are known to have a greater sensitivity to centrally administered angiotensin II, which may contribute to the hypertension. This data suggests that a difference in central angiotensin II receptors is at least partially responsible for the increased sensitivity.
mesh_terms: D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D002540:Cerebral Cortex / Q000378:metabolism; D006973:Hypertension / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013356:Subfornical Organ / Q000378:metabolism; D013687:Telencephalon / Q000378:metabolism*
chemical_list: D000804:Angiotensin II