Identification and metabolic implication of 1-deoxyglucose (1,5-anhydroglucitol) in human plasma.
1-Deoxyglucose (1,5-anhydroglucitol), a metabolite related to diabetes mellitus, was identified in human plasma by gas-liquid chromatography and by gas-liquid chromatography/mass spectrometry. Plasma polyols were accurately determined with a gas-liquid chromatograph equipped with an all-glass capillary column. The plasma content of 1-deoxyglucose in healthy persons varies with age. Although the precise physiological role of 1-deoxyglucose remains obscure, the method described here for determining the minor polyol components of plasma, as well as the findings of 1-deoxyglucose in the plasma of healthy subjects, may be useful for investigating the metabolic roles of 1-deoxyglucose.
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose; D002648:Child; D002675:Child, Preschool; D003837:Deoxy Sugars / Q000097:blood*; D003847:Deoxyglucose / Q000032:analysis / Q000097:blood* / Q000378:metabolism; D005312:Fetal Blood / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012016:Reference Values
D001786:Blood Glucose; D003837:Deoxy Sugars; C006584:1,5-anhydroglucitol; D003847:Deoxyglucose