The effect of silybin on lipid synthesis in ethanol-intoxicated rat hepatocytes in primary culture.
Rat liver cells in primary culture have been used to investigate the effects of ethanol and silybin on [2-3H]-glycerol incorporation into lipids. In these conditions, ethanol diminishes the incorporation of glycerol into lipids and modifies the labeling ratio: neutral lipid/phospholipid in favour of neutral lipid. 0.1 mM silybin can counteract this action of ethanol.
D000818:Animals; D002478:Cells, Cultured; D000431:Ethanol / Q000633:toxicity*; D005419:Flavonoids / Q000494:pharmacology*; D005990:Glycerol / Q000378:metabolism; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012838:Silymarin / Q000494:pharmacology*; D013997:Time Factors
D005419:Flavonoids; D008055:Lipids; D010743:Phospholipids; D012838:Silymarin; D000431:Ethanol; D005990:Glycerol