Enzymes of oxygen metabolism and lipid peroxidation on erythrocytes from copper-deficient rats.
1. Copper deficiency in the rat results in a high decrease of erythrocyte superoxide dismutase activity (by 70%), an increase of glutathione peroxidase activity (by 17%) and glucose 6-phosphate dehydrogenase activity (by 40%) and no change in catalase activity. 2. Ascorbate (30 nM) and copper (10 and 50 nmol/mg protein) enhance about 2-fold the lipid peroxidation of erythrocyte membranes from copper-deficient rats. 3. The osmotic stability of copper-deficient rat erythrocytes is higher compared with that of the controls.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D002374:Catalase / Q000097:blood; D003300:Copper / Q000172:deficiency*; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D010101:Oxygen Consumption; D051381:Rats; D013482:Superoxide Dismutase / Q000097:blood
D008054:Lipid Peroxides; D003300:Copper; D005954:Glucosephosphate Dehydrogenase; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D001205:Ascorbic Acid