title: Time-density evaluation of the liver after iosulamide meglumine: a tissue-specific CT contrast agent.
abstract: Iosulamide meglumine, a new intravenous biliary contrast agent, was evaluated as a potential hepatic contrast agent utilizing computed tomographic scanning. Time-density data in dogs were generated following 56.7 and 75.6 mg iodine/kg body weight. The iodine was administered both as an iosulamide meglumine bolus injection and a 0.77 ml/min infusion. The greatest increase in x-ray attenuation (24 HU) was observed within 45 minutes after the 75.6 mg iodine/kg body weight infusion technique, which resulted in excellent hepatic opacification. The long duration of increased x-ray attenuation of hepatocytes produced by iosulamide meglumine would be useful in the CT detection of hepatic mass lesions which do not contain normally functioning hepatic cells.
mesh_terms: D000818:Animals; D001835:Body Weight; D003287:Contrast Media / Q000008:administration & dosage; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000008:administration & dosage; D004285:Dogs; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007668:Kidney / Q000000981:diagnostic imaging; D008099:Liver / Q000000981:diagnostic imaging*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D003973:Diatrizoate; C028779:iosulamide meglumine; D003974:Diatrizoate Meglumine