The effect of amphotericin B on the permeability of lipid bilayers to divalent trace metals.
In this study amphotericin B released the divalent trace metals Zn2+, Co2+, Cu2+, Ni2+, Mn2+, Fe2+, Cd2+ and Pb2+ from multilamellar liposomes containing cholesterol. This observation is consistent with amphotericin B channels being permeable to these metals, and it is proposed, therefore, that the antibiotic may be useful in investigating the metabolism of these elements.
D000666:Amphotericin B; D002413:Cations, Divalent; D002784:Cholesterol; D007700:Kinetics; D008051:Lipid Bilayers; D008670:Metals; D008954:Models, Biological
D002413:Cations, Divalent; D008051:Lipid Bilayers; D008670:Metals; D000666:Amphotericin B; D002784:Cholesterol