The hippocampal corticosterone receptor system of the homozygous diabetes insipidus (Brattleboro) rat.
The binding of [3H] corticosterone to hippocampal cytosol receptors of Brattleboro rats homozygous for diabetes insipidus (Ho-Di) and of normal Brattleboro rats (Ho-No) was investigated at 24 h after removal of the adrenals. The apparent maximal binding capacity of the Ho-Di hippocampal corticosterone receptor system was about 30% less than that of the Ho-No rats. Substitution of the vasopressin deficient rats with 1E pitressin tannate in oil partially restores the hippocampal corticosterone receptor level towards that of the control animals.
D000315:Adrenalectomy; D000818:Animals; D001127:Arginine Vasopressin; D003919:Diabetes Insipidus / Q000378:metabolism*; D006624:Hippocampus / Q000032:analysis*; D006720:Homozygote; D008297:Male; D051381:Rats; D011910:Rats, Brattleboro; D011965:Receptors, Glucocorticoid / Q000032:analysis*; D011987:Receptors, Steroid / Q000032:analysis*; D014667:Vasopressins / Q000627:therapeutic use
D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; C024357:corticosterone receptor; C016671:pitressin tannate; D014667:Vasopressins; D001127:Arginine Vasopressin