title: Diaziquone, 2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone, plasma and cerebrospinal fluid kinetics.
abstract: Plasma and cerebrospinal fluid (CSF) kinetics of diaziquone, 2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone (AZQ), were evaluated after intravenous injection in patients with implanted Ommaya reservoirs. After a 30-min infusion plasma disappearance was very rapid, with a disposition half-life of 2 to 6 min and on elimination half-life of 25 to 35 min. Area under the concentration-time curve for CSF was 22% to 42% of the corresponding plasma area. Based upon total plasma AZQ concentration, volume of distribution for AZQ was 2.0 to 10.0 l/m2. Plasma binding of AZQ was 79% in one normal subject. When the effect of plasma binding is considered, distribution volumes are more plausible and it appears that free plasma AZQ is completely available to the CSF.
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D001388:Aziridines / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D001389:Azirines / Q000378:metabolism*; D016227:Benzoquinones; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D011485:Protein Binding
chemical_list: D000970:Antineoplastic Agents; D001388:Aziridines; D001389:Azirines; D016227:Benzoquinones; C029108:diaziquone