Clustering of anthropometric parameters, glucose tolerance, and serum lipids in children with high and low beta- and pre-beta-lipoproteins. Bogalusa Heart Study.
Children initially aged 21/2 to 14 years living in Bogalusa, Louisiana (n = 2530) were examined twice, 3 years apart, for fasting serum pre-beta- and beta-lipoprotein cholesterol (beta-LPC) levels. Based on averages of these levels, the children were ranked for pre-beta- and beta-LPC in combinations of extreme quintiles (low-low, high-high) or quartiles (low-high, high-low), n = 388, and were reexamined for serum lipids, lipoprotein cholesterol, glucose tolerance, and anthropometry. Skinfolds were thicker in whites than in blacks except for subscapular skinfold. Children in the high-high stratum were heavier and more obese. The postglucose insulin level was positively correlated with fasting serum triglycerides and pre-beta-LPC. Compared with other strata, high-high strata showed more clustering among half-hour and 1-hour plasma insulin, serum triglycerides and pre-beta-LPC, and trunk skinfolds. We conclude that racial differences in lipid and carbohydrate metabolism occur in all four strata, and that a strong clustering occurs more in the high-high stratum, which may, in part, explain the coincidence of several high cardiovascular risk factor levels observed in the same children. These observations document in free-living children changes of obesity, plasma glucose, and insulin metabolism related to serum lipoproteins that are involved in the early natural history of atherosclerosis.
D000273:Adipose Tissue / Q000032:analysis / Q000502:physiology; D000293:Adolescent; D000375:Aging; D000886:Anthropometry; D001786:Blood Glucose / Q000032:analysis / Q000502:physiology; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood / Q000502:physiology; D015243:Cholesterol, VLDL; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000032:analysis / Q000502:physiology; D008055:Lipids / Q000097:blood / Q000502:physiology; D008077:Lipoproteins, LDL / Q000097:blood* / Q000502:physiology; D008079:Lipoproteins, VLDL / Q000097:blood* / Q000502:physiology; D008145:Louisiana; D008297:Male; D009765:Obesity / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D012306:Risk; D013029:Space-Time Clustering; D014280:Triglycerides / Q000097:blood / Q000502:physiology
D001786:Blood Glucose; D015243:Cholesterol, VLDL; D007328:Insulin; D008055:Lipids; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol