title: Short-term treatment of osteoarthritis: a comparison of sodium meclofenamate and ibuprofen.
abstract: A double-blind crossover study compared sodium meclofenamate (300 mg daily) and ibuprofen (900 mg daily) in thirty patients with osteoarthritis. Each treatment period was of 3 weeks duration. Both drugs were effective in reducing the severity of joint symptoms and in improving the range of motion, with the exception of spine movement which did not show any changes from the baseline. Tolerance was good.
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005260:Female; D006621:Hip Joint / Q000187:drug effects; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects / Q000627:therapeutic use*; D007719:Knee Joint / Q000187:drug effects; D008297:Male; D008469:Meclofenamic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D010146:Pain / Q000188:drug therapy; D010817:Physician-Patient Relations; D013131:Spine / Q000187:drug effects; D013997:Time Factors; D062367:ortho-Aminobenzoates / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D062367:ortho-Aminobenzoates; D008469:Meclofenamic Acid; D007052:Ibuprofen