Comparison of the bioavailability of Redergin tablets (1.0 mg) and Redergin solution.
Pharmacokinetic investigations of Redergin LEK oral tablets (1.0 mg, dihydroergotoxine methanesulfonate) described in this article proved the efficacy of this pharmaceutical formulation. The properties of Redergin tablets almost completely correspond to results obtained when the active substance is applied as solution. The bioavailability of the formulation Redergin oral tablet is only a few percent lower than that of Redergin solution. A comparison with intravenous application of dihydroergotoxine methanesulfonate established that the bioavailability of Redergin oral tablet (1.0 mg) is 34% and Redergin solution 38%.
D000328:Adult; D001682:Biological Availability; D004088:Dihydroergotoxine / Q000008:administration & dosage* / Q000378:metabolism; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012996:Solutions; D013607:Tablets
D004338:Drug Combinations; D012996:Solutions; D013607:Tablets; D004088:Dihydroergotoxine