[Histological survey on the behaviour of antidiarrheal drugs under in vitro conditions (author's transl)].
The effect of four antidiarrheal drugs (China clay, bentonite, pectin, Kaoprompt H) on the epithelia of murine small intestine and colon was studied under in vitro conditions with histological techniques. In this experiment, the drugs coarsely coated the guts' surface without outlining details or protruding into clefts. The resistance of the layers to rinsing is slightly different. None of the substances was able to protrude between the microvilli. Best intrusion was shown by pectin. The transfer of the experimental results to in vivo conditions is discussed.
D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology*; D001546:Bentonite / Q000494:pharmacology; D003106:Colon / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000648:ultrastructure; D007421:Intestine, Small / Q000187:drug effects*; D007616:Kaolin / Q000494:pharmacology; D051379:Mice; D008871:Microvilli / Q000648:ultrastructure; D010368:Pectins / Q000494:pharmacology
D000930:Antidiarrheals; D001546:Bentonite; D007616:Kaolin; D010368:Pectins
Histologische Untersuchungen zum Verhalten antidiarrhoisch wirkender Substanzen unter in vitro-Bedingungen.