Carriers and noncarriers of haemophilia A. Evaluation of bleeding symptoms registered by a self-administered questionnaire with binary (no/yes) questions.
Carriers of haemophilia A were recently described to have significantly more bleeding symptoms than healthy females. Eighteen obligate carriers and 20 females classified as carriers with approximately 95% confidence, as described in an accompanying paper, were compared with 56 noncarriers with respect to ten bleeding symptoms, registered by a questionnaire. A rank-order of negative findings indicating noncarrier state is presented, as well as a rank order of positive findings indicating carrier state. A summation index of the total diagnostic capacity of the ten questions shows that carriers have more bleeding symptoms than healthy females.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002648:Child; D002675:Child, Preschool; D005243:Feces / Q000032:analysis; D005260:Female; D006580:Genetic Carrier Screening; D006417:Hematuria / Q000235:genetics; D006467:Hemophilia A / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D006470:Hemorrhage / Q000235:genetics; D006801:Humans; D008297:Male; D008796:Metrorrhagia / Q000235:genetics; D008875:Middle Aged; D009668:Nose Diseases / Q000235:genetics; D007744:Obstetric Labor Complications / Q000235:genetics; D011247:Pregnancy; D011795:Surveys and Questionnaires; D013924:Thrombophlebitis / Q000235:genetics; D013927:Thrombosis / Q000235:genetics; D014081:Tooth Extraction / Q000009:adverse effects; D014592:Uterine Hemorrhage / Q000150:complications