title: Comparison of the effects of dobutamine, dopamine, and isoproterenol on hypoxic pulmonary vasoconstriction in the pig.
abstract: The relative vasodilating properties of isoproterenol, dopamine, and dobutomine on hypoxic pulmonary vasoconstriction were examined in isolated pig lungs, ventilated and perfused in situ. The flow-resistant properties of the pulmonary circulation were assessed by measuring the relationship between pulmonary arterial pressure (PAP) and flow (Q). Hypoxia ( a decrease in inspired O2 tension form 200 torr to 50 torr) caused a rightward shift and decreased in the slope of this relationship. This increase PAP an average of 18.8 torr when measured at a blood flow of 1 L/min. Isoproterenol and dobutamine inhibited hypoxic pulmonary vasoconstriction, whereas dopamine had no effect. Because of its relative freedom from adverse side-effects in clinical trials, dobutamine should be considered in patients with hypoxic pulmonary vasoconstriction and right heart failure.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000494:pharmacology*; D004280:Dobutamine / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000860:Hypoxia / Q000503:physiopathology*; D007545:Isoproterenol / Q000494:pharmacology*; D008168:Lung / Q000098:blood supply*; D011651:Pulmonary Artery; D013552:Swine; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D002395:Catecholamines; D004280:Dobutamine; D007545:Isoproterenol; D004298:Dopamine