Urinary excretion of urate in renal calcium stone disease and in renal tubular acidification disturbances.
The 24-hour urinary excretion of urate was investigated in 467 consecutive stone formers - 350 males and 117 females - and 89 apparently healthy controls with no history of stone disease. Males had a higher urinary excretion of urate than females but there was no difference between stone formers and controls. Urinary urate decreased with advancing age. Patients with a proximal tubular acidification defect had a lower urate clearance than patients with a normal acidification of the urine. Patients with hyperuricosuria presented a higher frequency of stone operations but a lower stone episode rate than matched normouricosuric stone formers. Hyperuricosuria in combination with renal acidification defects was associated with the highest frequency of stone operations. Hyperuricosuric patients also had a higher excretion of calcium than normouricosuric patients. Hyperuricosuria is not a common feature of calcium stone disease but when present is associated with a more severe stone disease in terms of stone operations.
D000141:Acidosis, Renal Tubular / Q000652:urine*; D000328:Adult; D000367:Age Factors; D000368:Aged; D002129:Calcium Oxalate; D002130:Calcium Phosphates; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000378:metabolism / Q000652:urine*; D007671:Kidney Concentrating Ability; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D014527:Uric Acid / Q000652:urine*
D002130:Calcium Phosphates; D002129:Calcium Oxalate; D014527:Uric Acid