title: Preference for fixed vs self-selected durations of brain stimulation in rats administered D-amphetamine sulphate.
abstract: Rats implanted with stimulating electrodes in the region of the lateral hypothalamus were allowed the opportunity to respond on (a) a fixed duration lever (b) a variable duration lever or (c) were given a choice between responding on either the lever that delivered the fixed duration of electrical brain stimulation or the lever that allowed the animal to control the duration of electrical brain stimulation. Amphetamine increased rates of responding in both the fixed and variable duration conditions but total duration of brain stimulation was comparable in the two conditions. When given a choice of levers, rats did not prefer either the fixed or variable duration lever. After treatment with d-amphetamine, however, a marked preference for the variable duration lever was observed, although total duration of brain stimulation received in the choice procedure was comparable to that received when either the fixed or variable levers were presented alone. These findings were discussed in terms of brain stimulation preference following amphetamine and its relationship to reward value in the rat.
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004558:Electric Stimulation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012201:Reward; D012653:Self Stimulation / Q000187:drug effects*
chemical_list: D003913:Dextroamphetamine