Cytogenetic activities of 3 sulphonamides.
The cytogenetic effects of 3 sulphonamides were analysed by a standard Allium test. Mitotic and chromosomal abnormalities are described. The sulphonamides tested were sulphadiazine, sulphadimidine and sulphaphenazole. Actively dividing cells were treated with 4 concentrations of each drug for 4, 24 and 48 h. Treatment for 4 h caused a marked increase in the mitotic index (MI), whereas longer treatment induced a severe reduction in mitotic activity. The 3 drugs produced a number of mitotic abnormalities resulting from an action of the spindle apparatus. They also induced some chromosomal abnormalities by direct or indirect action on the chromosomes.
D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects; D009152:Mutagenicity Tests; D009153:Mutagens; D010944:Plants / Q000235:genetics; D013449:Sulfonamides / Q000494:pharmacology*; D013997:Time Factors
D009153:Mutagens; D013449:Sulfonamides