[Phospholipid composition of liver and Ehrlich ascites carcinoma cell nuclei during tumor growth and after irradiation of tumor hosts].
The phospholipid composition of liver and Ehrlich ascite carcinoma cell nuclei during tumour growth and after irradiation of tumour hosts was studied. In tumour cell nuclei the total phospholipid content is significantly increased; the percentage maximum with respect to total lipid content is reached on the 8-9th day of tumour growth, that calculated per mg of protein--on the 6-7th day. The relative percentage of phospholipids in liver cell nuclei of tumour hosts is extremally decreased, that calculated per mg of protein is increased more than 3-fold with a maximum on the 6-7th day of tumour growth. The most noticeable changes in individual phospholipids are the increase in the relative content (%) of sphingomyelin and phosphatidyl serine and a decrease of phosphatidyl choline and phosphatidyl ethanolamine in a tumour cell nuclei on the 6-10th day of tumour growth. These changes are presumably non-specific for the tumour, since similar data on the content of these phospholipids were reported from earlier experiments, when the liver cell nuclei of the tumour hosts were investigated at early stages of tumour growth, i. e. on the 2nd-4th day after reinoculation. At terminal stages of tumour growth the phospholipid content in the liver nuclei of tumour hosts returns to normal level.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism / Q000528:radiation effects*; D007700:Kinetics; D008099:Liver / Q000378:metabolism / Q000528:radiation effects*; D051379:Mice; D010713:Phosphatidylcholines / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000378:metabolism; D010718:Phosphatidylserines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D013109:Sphingomyelins / Q000378:metabolism
D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010718:Phosphatidylserines; D010743:Phospholipids; D013109:Sphingomyelins
Sostav fosfolipidov iader kletok pecheni i opukholi v protsesse rosta astsitnoĭ kartsinomy Erlikha i rpi obluchenii zhivotnykh-opukholenositeleĭ.