Serum protein binding and free concentration of phenytoin and phenobarbitone in pregnancy.
1 The effect of pregnancy on the binding of phenytoin and phenobarbitone to serum proteins was studied in normal women and in drug treated epileptic women. 2 The binding of both drugs was reduced during pregnancy. The reduction correlated positively with the gestational age and negatively with the serum albumin concentration. 3 In spite of the increase in unbound fraction, both the total and free serum concentrations of phenytoin were decreased in late pregnancy.
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D010634:Phenobarbital / Q000378:metabolism*; D010672:Phenytoin / Q000097:blood*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011485:Protein Binding
D001798:Blood Proteins; D010672:Phenytoin; D010634:Phenobarbital