Biliary excretion of sulfobromophthalein in isolated perfused livers from normal and spironolactone-treated rats.
Bile flow and biliary excretion of sulfobromophthalein (BSP) was examined in isolated perfused livers from normal and spironolactone(SP)-treated rats. BSP biliary excretion contributed to the bile production in both groups. Moreover SP increased BSP biliary excretion but transfer of dye from plasma into liver was not affected.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013148:Spironolactone / Q000494:pharmacology*; D013448:Sulfobromophthalein / Q000378:metabolism*
D013448:Sulfobromophthalein; D013148:Spironolactone