title: Changes in high affinity choline uptake in rat cortex following lesions of the magnocellular forebrain nuclei.
abstract: High affinity choline uptake (HACU) and choline acetyltransferase (CAT) were measured in the cerebral cortex of rats 4 and 20 days after placing electrolytic lesions in the magnocellular forebrain nuclei (MFN) or in the pallidum. Four days after MFN lesion a 40-50% decrease in ipsilateral cortical HACU was found and a slightly smaller decrease was found 4 days after the pallidum lesion. Twenty days after the lesion, HACU activity returned to control values in the ipsilateral parietal cortex, its decrease was smaller than 4 days postlesion in the ipsilateral frontal cortex and a significant increase was found in the contralateral cortex. CAT activity showed a 40% decrease in the frontal, parietal and occipital ipsilateral cortex 4 days after MFN lesion. The same decrease was found 20 days postlesion. However, at this time a significant increase in CAT activity was detected in the contralateral cortex. The ipsilateral recovery of HACU activity 20 days after the lesions and the contralateral increase in HACU and CAT activity demonstrate the remarkable and widespread functional adjustment associated with discrete brain lesions. The existence of a large cholinergic pathway projecting to the neocortex from the basal forebrain region is also confirmed.
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000201:enzymology*; D002794:Choline / Q000378:metabolism*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D004292:Dominance, Cerebral / Q000502:physiology; D005625:Frontal Lobe / Q000201:enzymology; D005917:Globus Pallidus / Q000502:physiology*; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D009778:Occipital Lobe / Q000201:enzymology; D010296:Parietal Lobe / Q000201:enzymology; D011301:Preoptic Area / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002795:Choline O-Acetyltransferase; D002794:Choline