title: Short-duration ('minutes') therapy with dithranol for psoriasis: a new out-patient regimen.
abstract: Eighty-five patients with widespread psoriasis were treated with daily short-term applications of dithranol and salicylic acid in yellow soft paraffin. Two different schedules were used: (1) '3-h' therapy using increasing dithranol concentrations (o.I, o.25, o.5, I, 2%) for 3 h; (2) 'minutes' therapy using high dithranol concentrations (I, 2, 3%) for only 10-20 min. In comparison with the standard dithranol therapy, applied for 24 h each day, the '3-h' therapy showed equal efficacy clinically and histologically, and the 'minutes' therapy was significantly better than the standard therapy, reducing the mean clearing time by 6.8 days. Daily short-term ('minutes') therapy combines all the advantages of dithranol with a convenient and readily acceptable mode of application for home use.
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000873:Anthracenes / Q000008:administration & dosage*; D000875:Anthralin / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D011565:Psoriasis / Q000188:drug therapy*; D012646:Self Administration
chemical_list: D000873:Anthracenes; D000875:Anthralin