The potentiation of warfarin anticoagulation by amiodarone.
The potentiation of the anticoagulant effect of sodium warfarin by amiodarone is reported in 10 patients. Amiodarone appears to augment the depression of vitamin K-dependent coagulation factors caused by warfarin by an uncertain mechanism, and may lead to serious bleeding. The maintenance dose of warfarin should be halved when amiodarone and warfarin are prescribed together.
D000368:Aged; D000638:Amiodarone / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D001572:Benzofurans / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000032:analysis; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011517:Prothrombin Time; D014812:Vitamin K; D014859:Warfarin / Q000008:administration & dosage / Q000494:pharmacology*
D001572:Benzofurans; D001779:Blood Coagulation Factors; D014812:Vitamin K; D014859:Warfarin; D000638:Amiodarone