title: Gentamicin-resistant staphylococci as hospital flora: epidemiology and resistance plasmids.
abstract: In 1979, gentamicin-resistant (Gmr) Staphylococcus aureus was recovered from the clinical specimens of 22 epidemiologically unrelated hospitalized patients; 78% of the patients evaluated were also colonized with Gmr coagulase-negative staphylococci. Endonuclease fingerprinting was used to compare the Gmr plasmids within pairs of isolates of S. aureus and coagulase-negative staphylococci recovered from nine patients. Plasmids differed between pairs but were concordant within four pairs. Thus, in vivo interspecific plasmid transfer, although infrequent, may be important in the sporadic occurrence of Gmr S. aureus. To define the epidemiology of endemic Gmr coagulase-negative staphylococci, culture surveys were performed over two years. Gmr coagulase-negative staphylococci were acquired by 80% of the infants in a special-care nursery that previously had an outbreak of Gmr S. aureus. Among adult inpatients, a 48% colonization rate was related to prior exposure to antibiotics. In contrast, no colonization was found in outpatients or antepartum mothers.
mesh_terms: D000328:Adult; D003428:Cross Infection / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D005839:Gentamicins / Q000494:pharmacology*; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008826:Microbial Sensitivity Tests; D010957:Plasmids; D013210:Staphylococcus / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D005839:Gentamicins