Accumulation of dolichols in brains of elderly.
Dolichol levels in human brain gray matter increased from 18 micrograms/g in 6-year-old to 263 micrograms/g in 68-year-old human brain gray matter. High performance liquid chromatographic analysis shows dolichols ranging from 14 to 22 isoprene units with 19 isoprene units containing species predominating (approximately 44%). This may be the first report of an appreciable accumulation of a lipid in brains of elderly.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D000818:Animals; D001921:Brain / Q000254:growth & development*; D001923:Brain Chemistry; D002648:Child; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000032:analysis*; D004286:Dolichols / Q000032:analysis*; D006801:Humans; D008099:Liver / Q000032:analysis; D013552:Swine
D004224:Diterpenes; D004286:Dolichols