title: [Investigations on the retention period and tolerance of Hexabrix as x-ray contrast medium in arthrography (author's transl)].
abstract: Arthrography of the knee joint was performed in 12 domestic pigs using Hexabrix (meglumine and sodium ioxaglate). Conray EV (sodium and meglumine iothalamate) was used for comparison. X-ray films were taken at periodic intervals. Hexabrix was found to stay slightly longer in the joints. The animals were sacrificed at 3 different times after injection and the synovial membrane of the knee joints and the joint cartilage of the patella were assessed histologically. 3 of 6 joints showed a strictly limited focus with leukocytes in the fat pad 24 hours after the injection. In the other cases no inflammatory reactions were seen after injection of the contrast media.
mesh_terms: D000818:Animals; D001175:Arthrography; D003287:Contrast Media; D004361:Drug Tolerance; D005260:Female; D007463:Iodobenzoates; D007485:Ioxaglic Acid; D008297:Male; D013552:Swine; D014283:Triiodobenzoic Acids
chemical_list: D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D007485:Ioxaglic Acid
vernacular_title: Untersuchungen zur Verweildauer und zur Verträglichkeit von Hexabrix als Röntgenkonstrastmittel zur Arthrographie.