Continuous suxamethonium infusion for microlaryngeal surgery.
The suxamethonium infusion requirements to maintain a 100% neuromuscular block in patients undergoing microlaryngeal surgery were determined. Anaesthesia was maintained with halothane and the neuromuscular block monitored with a peripheral nerve stimulator delivering train-of-four stimuli. Suxamethonium requirements varied directly with time in a linear manner and the onset and recovery time of the block increased with time. No difficulties in recovery were observed when the duration of infusion was less than l h, even when the nature of the block had altered to the non-depolarizing type. A good correlation was observed between neuromuscular block as indicated by peripheral nerve stimulation and laryngeal muscle paralysis.
D000328:Adult; D000368:Aged; D006801:Humans; D007263:Infusions, Parenteral; D007830:Larynx / Q000601:surgery*; D008866:Microsurgery; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects; D013390:Succinylcholine / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors
D013390:Succinylcholine