Enhancement of viral transformation of hamster embryo cells by pretreatment with 4-chloromethylbiphenyl.
Treatment of Syrian hamster embryo cells with 4-chloromethylbiphenyl produced reproducible and quantitative concentration-dependent enhancement of viral transformation the statistical significance of which was independent of cell lethality. These results suggest this compound has carcinogenic potential since positive results in this mammalian cell bioassay system closely correlate with the carcinogenic potential of many diverse compounds and with structurally similar agents, especially other chlorinated compounds.
D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology*; D002273:Carcinogens / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002472:Cell Transformation, Viral / Q000187:drug effects*; D006224:Cricetinae; D004622:Embryo, Mammalian; D008647:Mesocricetus
D001713:Biphenyl Compounds; D002273:Carcinogens; C033487:4-chloromethylbiphenyl