Biological activities of toxins A and B of Clostridium difficile.
Examination of the biological activities of the two known toxins of Clostridium difficile revealed that one of the toxins (toxin A) elicited a hemorrhagic fluid response in rabbit intestinal loops and a positive fluid response in infant mice. The other toxin (toxin B) did not produce a significant fluid response in either model, although the toxin was more lethal in infant mice. Both toxins elicited erythematous and hemorrhagic skin reactions and increased vascular permeability in rabbit skin.
D000818:Animals; D001427:Bacterial Toxins / Q000633:toxicity*; D001826:Body Fluids / Q000378:metabolism; D002199:Capillary Permeability / Q000187:drug effects; D003013:Clostridium; D004890:Erythema / Q000139:chemically induced; D007413:Intestinal Mucosa / Q000378:metabolism; D011817:Rabbits; D012882:Skin Tests
D001427:Bacterial Toxins