[Proteolytic enzymes and their inhibitors in the tumors and blood serum of patients with breast neoplasms].
Content of proteinases and trypsin inhibitor was studied in non-malignant and malignant tumors as well as in blood serum of 120 patients with mammary gland neoplasm. In malignant tumors activity of acid and casein-degrading proteinases was increased as compared with non-impaired tissue of mammary gland. Activity of proteolytic enzymes in non-malignant tumors corresponded to an intermediate value between the activity in malignant tumors and in non-impaired tissue. Content of the trypsin inhibitor was distinctly increased in non-malignant tumors and unaltered -- in malignant tissues. The inhibitor content was increased in blood serum of patients with metastases in lymphoid nodes. These data demonstrate the activation of proteolysis in malignant mammary gland and suggest a possible role of proteolytic enzymes in carcinogenesis.
D001940:Breast / Q000201:enzymology; D001943:Breast Neoplasms / Q000032:analysis*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010447:Peptide Hydrolases / Q000032:analysis*; D011480:Protease Inhibitors / Q000032:analysis*
D011480:Protease Inhibitors; D010447:Peptide Hydrolases
Proteoliticheskie fermenty i ikh ingibitory v opukholiakh i syvorotke krovi bol'nykh s novoobrazovaniiami molochnoĭ zhelezy.