title: Bio-inorganic regulation of pathways of carbohydrate and lipid metabolism. 1. Effect of iron and manganese on the enzyme profile of pathways of carbohydrate metabolism in adipose tissue during development.
abstract: The effect of Fe2+ and Mn2+ on the pattern of emergence of enzymes in adipose tissue was studied in weaned rats given a high-fat diet; comparison was made with groups given a high-carbohydrate diet for 3 weeks. The addition of Fe2+ resulted in increased activity of key enzymes of glycolysis, the pentose phosphate pathway and lipogenesis, while further supplementation with Mn2+ enhanced these changes. The Mn2+ treatment thus appeared partially to overcome the regulatory feedback mechanisms of the high-fat diet and to provide a signal for the increase in enzymes involved in glucose oxidation and lipogenesis.
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D050260:Carbohydrate Metabolism; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D007501:Iron / Q000494:pharmacology*; D000090463:Iron Deficiencies; D050356:Lipid Metabolism; D008297:Male; D008345:Manganese / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D008345:Manganese; D007501:Iron