[Composition and metabolism of high-density lipoproteins in normal rabbits of different ages and in experimental atherosclerosis].
It is shown that peculiarities of high-density lipoproteids metabolism in old rabbits as compared with young ones in norm are represented by an increase in the activity of lecithincholesterol acyltransferase (EC 2.3.1.4.3) in blood plasma and in time of half-removal of labelled high-density 3H lipoproteids by a decrease in the activity of cholesterol-7 alpha-monooxigenase in the liver. The content of cholesterol esters in the composition of high-density lipoproteids increases with ageing. Under experimental atherosclerosis the decomposition of high-density lipoproteids intensifies, the activity of cholesterol-7 alpha-monooxigenase increases and that of lecithincholesterol acyltransferase is inhibited equally in uneven-aged rabbits. The content of free cholesterol increases and that of cholesterol esters decreases in the high-density lipoproteid composition.
D000375:Aging; D000818:Animals; D001161:Arteriosclerosis / Q000097:blood*; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism; D002788:Cholesterol Esters / Q000097:blood; D004195:Disease Models, Animal; D007700:Kinetics; D008075:Lipoproteins, HDL / Q000097:blood*; D008099:Liver / Q000201:enzymology; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood*; D011817:Rabbits; D012016:Reference Values
D002788:Cholesterol Esters; D008075:Lipoproteins, HDL; D002790:Cholesterol 7-alpha-Hydroxylase; D007862:Phosphatidylcholine-Sterol O-Acyltransferase
Sostav i obmen lipoproteidov bysokoĭ plotnosti u krolikov raznogo vozrasta v norme i pri éksperimental'nom ateroskleroze.