[Computation of the parameters of complex formation of chemical compounds with serum albumin according to the degree of completeness of conformational transitions ion the protein molecule].
A new linear expression of low mass action for computation of binding parameters based on the data of completeness of conformational changes in the protein molecule is proposed. These data may be also obtained by spectrofluorometry or other methods. This mode of computation allows one to show the presence of specific receptors on the protein molecule, determine adaptive structural changes in protein, preceding ligand fixation.
D001665:Binding Sites; D004138:Dinitrocresols / Q000378:metabolism; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011485:Protein Binding; D011487:Protein Conformation; D012709:Serum Albumin / Q000378:metabolism*
D004138:Dinitrocresols; D004364:Pharmaceutical Preparations; D012709:Serum Albumin; C024132:4,6-dinitro-o-cresol
Raschet parametrov kompleksoobrazovaniia khimicheskikh soedineniĭ s syvorotochnym al'buminom po stepeni zavershennosti konformatsionnogo perekhoda belkovoĭ molekuly.