title: Turnover rate of skeletal alkaline phosphatase in humans.
abstract: Two patients with Paget's disease of bone were subjected to plasmapheresis. Alkaline phosphatase activities of serum declined sharply, but returned to preplasmapheresis values within eight to 10 days. The biological half-life of circulating skeletal alkaline phosphatase, as calculated from these experiments, is between 1.12 and 2.15 days.
mesh_terms: D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood*; D001322:Autoanalysis; D001842:Bone and Bones / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D010001:Osteitis Deformans / Q000201:enzymology* / Q000628:therapy; D010956:Plasmapheresis; D012016:Reference Values; D013997:Time Factors
chemical_list: D000469:Alkaline Phosphatase