Evidence for host-mediated antitumor activity in the treatment of experimental tumor with a hot water extract from BCG.
Studies were undertaken for the evaluation of the mechanism responsible for antitumor effects of hot water extract (HWE) of BCG on murine ascites tumor cells. a) The viability of tumor cells has remained unchanged after incubation of tumor cells in the medium containing HWE. b) There was no difference in survival time between mice which had received tumor cells treated as in (a) and the control mice. c) Silica, carragheenan and cortisone acetate reduced the antitumor effect of HWE in ddY mice and C3H/He mice which had been inoculated with Sarcoma 180 cells or MH134 cells. d) The growth of tumor cells was retarded when they were inoculated subcutaneously together with peritoneal cells from HWE-injected mice. These results indicate the participation of host-mediated antitumor activity when neoplasms were treated with HWE.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D001500:BCG Vaccine / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology; D007167:Immunotherapy; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000276:immunology* / Q000628:therapy
D001500:BCG Vaccine; D006854:Hydrocortisone