DNA-protein cross-linking by the mycotoxin, botryodiplodin, in mammalian cells.
Botryodiplodin, a mycotoxin isolated from a strain of Penicillium roqueforti, induces DNA-protein cross-links in mammalian cells. This action depends upon the presence of the hydroxyl group at the position 2 of the molecule. The mechanism involved in the formation of cross-linkings is discussed.
D000818:Animals; D002460:Cell Line; D002499:Centrifugation, Density Gradient; D006224:Cricetinae; D003412:Cricetulus; D003432:Cross-Linking Reagents / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism*; D005663:Furans / Q000494:pharmacology*; D008099:Liver; D008114:Liver Neoplasms, Experimental; D008168:Lung; D008297:Male; D009183:Mycotoxins / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D003432:Cross-Linking Reagents; D005663:Furans; D009183:Mycotoxins; D011506:Proteins; C006789:botryodiplodin; D004247:DNA