Non-immunoglobulin fraction of human milk protects rabbits against enterotoxin-induced intestinal fluid secretion.
Human milk was fractionated by ammonium sulphate precipitation and column chromatography. A milk fraction depleted of secretory immunoglobulin A and with an apparent molecular weight of greater than 400,000 inhibited fluid secretion induced by cholera toxin and Escherichia coli heat-labile toxin in rabbit ileal loops.
D000818:Animals; D001427:Bacterial Toxins; D002772:Cholera Toxin / Q000037:antagonists & inhibitors*; D004768:Enterotoxins / Q000037:antagonists & inhibitors*; D004797:Enzyme-Linked Immunosorbent Assay; D029968:Escherichia coli Proteins; D005590:Fractional Precipitation; D007413:Intestinal Mucosa / Q000378:metabolism*; D008895:Milk, Human / Q000032:analysis*; D008970:Molecular Weight; D011817:Rabbits
D001427:Bacterial Toxins; D004768:Enterotoxins; D029968:Escherichia coli Proteins; D002772:Cholera Toxin; C027538:heat-labile enterotoxin, E coli