Precipitate formation of some sulfonated tetrazolthiomethyl cephalosporins with basic chemicals.
Cephalosporins containing a thiomethyltetrazole-sulfomethyl or sulfoaminoethyl substituent at the three-position react in aqueous solution with protamine or quinine to form a precipitate. This phenomenon may provide some insight into their pharmacokinetics and modes of action especially as it relates to the high and prolonged serum levels and high degree of serum protein-binding.
D001798:Blood Proteins / Q000378:metabolism; D002511:Cephalosporins / Q000097:blood; D055598:Chemical Phenomena; D011232:Chemical Precipitation; D002621:Chemistry; D007700:Kinetics; D011479:Protamines; D011485:Protein Binding; D011803:Quinine; D013329:Structure-Activity Relationship; D013451:Sulfonic Acids
D001798:Blood Proteins; D002511:Cephalosporins; D011479:Protamines; D013451:Sulfonic Acids; D011803:Quinine