Effect of actinomycin D and cycloheximide on experimental myocardial infarction in rats.
Actinomycin D, an inhibitor of DNA-directed RNA synthesis, or cycloheximide, a protein synthesis inhibitor, administered 24 h and 1 or 4 h respectively, before inducing coronary occlusion in conscious rats, offered marked protection against postinfarction ventricular fibrillation and sudden death. When actinomycin D was given 4 h prior to coronary ligation, the outcome of myocardial infarction was not influenced, the well-established cardioprotective effect of dexamethasone was however completely abolished. These results suggest that protein factors may be involved in the early events of myocardial infarction.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D003327:Coronary Disease / Q000503:physiopathology; D003513:Cycloheximide / Q000627:therapeutic use*; D003609:Dactinomycin / Q000627:therapeutic use*; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use; D004347:Drug Interactions; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains
D003609:Dactinomycin; D003907:Dexamethasone; D003513:Cycloheximide