title: [Subacute and subchronic percutaneous tolerance testing (28-day and 90-day test) of epicutaneously applied dis-infectants as demonstrated by the example of peroxyethanoic acid (author's transl)].
abstract: As compared to control animals, guinea-pigs to the shaved backs of which a dose of 0.16 ml of a 0.12% solution of PES/100g. of body mass had been applied twice daily for periods of 28 and 90 d, respectively (5 d of application being followed by 2 d without treatment), showed erythema, loss of hair, slower increase in mass, increased heart rate, smaller body mass/kidney mass and body mass/spleen mass  ratios, increases in leucocytes, ASAT, ALAT, LDH I and LDH III. In the 28-d test, slight inflammatory symptoms of the liver, kidneys and heart were observed in the experimental animals. These symptoms were more marked in the 90-d test, granulomata in the livers being particularly striking. A pneumonia of moderate to very marked degree is suggestive of the activation of a clinically latent PES infect whereby the inflammatory alterations in the kidneys might be explained by the formation of metastases.
mesh_terms: D000085:Acetates / Q000633:toxicity*; D000287:Administration, Topical; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004202:Disinfectants / Q000008:administration & dosage / Q000633:toxicity*; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D007249:Inflammation / Q000139:chemically induced; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010463:Peracetic Acid / Q000008:administration & dosage / Q000633:toxicity*; D012882:Skin Tests; D013997:Time Factors
chemical_list: D000085:Acetates; D004202:Disinfectants; D010463:Peracetic Acid
vernacular_title: Subakute und subchronische percutane Verträglichkeitsprüfung im 28-und 90-Tag-Test von Desinfektionsmitteln bei epicutaner Applikation, dargestellt am Beispiel von Peroxyethansäure.