Nitriphenol compound induces Ca-dependent exocytotic secretion of catecholamines by a direct effect on the plasma membranes of the adrenal medullary cells.
2,4-Dinitrophenol induced Ca-dependent secretion of adrenaline from the perfused adrenals of the rabbits. Secretion of adrenaline was accompanied by that of dopamine-beta-hydroxylase showing the exocytotic nature, 2,4,5-Trinitrophenol, which is devoid of uncoupling activity, and other nitrophenol compounds were also effective in inducing secretion, suggesting that secretion by nitrophenol compound is due to increased Ca entry through its direct effect on the plasma membrane.
D019297:2,4-Dinitrophenol; D000313:Adrenal Medulla / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D004140:Dinitrophenols / Q000494:pharmacology*; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism*; D004837:Epinephrine / Q000378:metabolism*; D007700:Kinetics; D011817:Rabbits
D004140:Dinitrophenols; D004299:Dopamine beta-Hydroxylase; D019297:2,4-Dinitrophenol; D002118:Calcium; D004837:Epinephrine