Time-course studies on the effects of oestradiol administration on the activity of some folate-metabolizing enzymes in chicken liver.
1. The specific activities of some enzymes of folate metabolism were measured in the liver of folate-treated and folate-deficient immature female chickens at intervals up to 9 days after an initial administration of 17 beta-oestradiol dipropionate. 2. An increase in dihydrofolate reductase activity after 3 days and decreases in 10-formyltetrahydrofolate synthetase and 5,10-methylenetetrahydrofolate dehydrogenase activities after 2 days became evident as a result of oestradiol treatment. 3. After 9 days, oestradiol caused a small decrease in glutamate formiminotransferase activity. 4. In folate-deficient chickens the activity of dihydrofolate reductase was decreased and that of serine hydroxymethyltransferase, 10-formyltetrahydrofolate synthetase and 5,10-methylenetetrahydrofolate dehydrogenase was increased in both non-hormone-treated and oestradiol-treated animals.
D000818:Animals; D002645:Chickens; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005492:Folic Acid / Q000378:metabolism* / Q000494:pharmacology; D005494:Folic Acid Deficiency / Q000378:metabolism*; D005574:Formate-Tetrahydrofolate Ligase / Q000378:metabolism*; D051042:Glutamate Formimidoyltransferase; D019877:Hydroxymethyl and Formyl Transferases; D007700:Kinetics; D008025:Ligases / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000378:metabolism*; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*; D014166:Transferases / Q000378:metabolism*; D000099295:Formyltetrahydrofolate Dehydrogenase
D004958:Estradiol; D005492:Folic Acid; D005574:Formate-Tetrahydrofolate Ligase; D051042:Glutamate Formimidoyltransferase; D019877:Hydroxymethyl and Formyl Transferases; D008025:Ligases; D000587:Oxidoreductases Acting on CH-NH Group Donors; D013762:Tetrahydrofolate Dehydrogenase; D014166:Transferases; D000099295:Formyltetrahydrofolate Dehydrogenase