Metabolism and distribution of labeled theophylline in the pregnant rat. Impairment of theophylline metabolism by pregnancy and absence of a blood-brain barrier in the fetus.
D000818:Animals; D001812:Blood-Brain Barrier; D001923:Brain Chemistry; D002110:Caffeine / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000187:drug effects*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D011919:Rats, Inbred Strains; D013806:Theophylline / Q000097:blood / Q000378:metabolism* / Q000652:urine; D014018:Tissue Distribution
D002110:Caffeine; D013806:Theophylline