Plasma concentrations and pharmacokinetics of misonidazole after intraperitoneal administration to the mouse.
The pharmacokinetics of misonidazole, a hypoxic-cell radiosensitizer, were determinated after intraperitoneal administration to standardized Balb/c mice. The experimental data was fitted, using non linear analysis, to plasma-concentration curves described by tri-exponential equations derived from a two-compartment model. The pharmacokinetic constants (absorption and elimination coefficients) were determinated.
D000818:Animals; D005260:Female; D007274:Injections, Intraperitoneal; D007700:Kinetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008920:Misonidazole / Q000008:administration & dosage / Q000097:blood*; D009593:Nitroimidazoles / Q000097:blood*; D013997:Time Factors
D009593:Nitroimidazoles; D008920:Misonidazole