Action mechanisms of gamma-aminobutyric acid (GABA) and glycine on rat cortical neurons.
The actions of GABA and glycine (Gly), iontophoretically applied to rat cortical neurons, were compared. These amino acids hyperpolarized the membrane cell, decreasing the membrane resistance. The results show that the ionic mechanisms involved in the inhibitory actions of GABA and Gly are probably the same in contrast with the results obtained in cat cortical neurons.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D005998:Glycine / Q000494:pharmacology*; D007478:Iontophoresis; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D005680:gamma-Aminobutyric Acid; D005998:Glycine