title: Lateral diffusion in an archipelago. Effects of impermeable patches on diffusion in a cell membrane.
abstract: Lateral diffusion of molecules in lipid bilayer membranes can be hindered by the presence of impermeable domains of gel-phase lipid or of proteins. Effective-medium theory and percolation theory are used to evaluate the effective lateral diffusion constant as a function of the area fraction of fluid-phase lipid and the permeability of the obstructions to the diffusing species. Applications include the estimation of the minimum fraction of fluid lipid needed for bacterial growth, and the enhancement of diffusion-controlled reactions by the channeling effect of solid patches of lipid.
mesh_terms: D002462:Cell Membrane / Q000502:physiology*; D004058:Diffusion; D004926:Escherichia coli; D008433:Mathematics; D008563:Membrane Lipids / Q000502:physiology; D008954:Models, Biological; D013696:Temperature
chemical_list: D008563:Membrane Lipids