Relationship between phagocytic activity of macrophages and delayed footpad reaction against syngeneic testicular cells.
The delayed footpad reaction against syngeneic testicular cells was studied in cyclophosphamide (CY)-pretreated mice whose mononuclear phagocyte system (MPS) was blocked with colloidal carbon or stimulated with Corynebacterium parvum (C. parvum). The delayed footpad reaction was augmented by MPS-blockade, whereas it was depressed by MPS-stimulation. It was observed that syngeneic testicular cells were phagocytized and degraded more effectively by C. parvum-stimulated macrophages in vitro and that the testicular antigen phagocytized by C. parvum-stimulated macrophages proved to become less immunogenic in cell transfer experiments.
D000818:Animals; D001324:Autoantigens; D002244:Carbon; D003520:Cyclophosphamide / Q000494:pharmacology; D006968:Hypersensitivity, Delayed; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D010587:Phagocytosis / Q000187:drug effects; D011425:Propionibacterium acnes / Q000276:immunology; D013737:Testis / Q000276:immunology*
D001324:Autoantigens; D002244:Carbon; D003520:Cyclophosphamide