Use of etorphine-acepromazine and diprenorphine in reversible neuroleptanalgesia of rats.
The death rate due to neuroleptanalgesia (0.35%) was significantly lower than for barbiturate anaesthesia (1.59%). Complications were few even when animals received multiple, repeated, anaesthesia, and depth of anaesthesia could be adjusted easily. Further, it could be reversed within minutes by the specific antagonist diprenorphine.
D000075:Acepromazine / Q000037:antagonists & inhibitors; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004174:Diprenorphine / Q000494:pharmacology; D004341:Drug Evaluation / Q000662:veterinary; D005048:Etorphine / Q000037:antagonists & inhibitors; D005260:Female; D008297:Male; D009019:Morphinans / Q000037:antagonists & inhibitors / Q000494:pharmacology; D009458:Neuroleptanalgesia / Q000401:mortality / Q000662:veterinary*; D051381:Rats / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000502:physiology; D012119:Respiration / Q000187:drug effects
D009019:Morphinans; D004174:Diprenorphine; D005048:Etorphine; D000075:Acepromazine