Effects of corticosteroids on the soluble creatine phosphokinase of the skeletal muscle of rats of various ages.
Effects of adrenalectomy, hydrocortisone and cortisone on the activity of creatine phosphokinase of the skeletal muscle of 7-, 30-, and 80-week old male rats were studied. The specific activity of the enzyme was the highest in the young and decreased in adult and old rats. However, its activity increased with age when expressed as units/mg DNA. Adrenalectomy decreased the activity in the young, but not in the adult and old rats. Hydrocortisone induced it in the young and old rats, but not in the adults rats. Cortisone induced it in the young and to some extent in the adult rats, but not in the old rats. The magnitude of induction was higher in the young rats with both hormones. Induction of enzyme was actinomycin D sensitive.
D000255:Adenosine Triphosphate / Q000097:blood; D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000315:Adrenalectomy; D000375:Aging; D000818:Animals; D003348:Cortisone / Q000494:pharmacology; D003402:Creatine Kinase / Q000378:metabolism*; D003609:Dactinomycin / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology; D008297:Male; D009132:Muscles / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
D000305:Adrenal Cortex Hormones; D003609:Dactinomycin; D000255:Adenosine Triphosphate; D003402:Creatine Kinase; D003348:Cortisone; D006854:Hydrocortisone