[Effect of armin and dipyroxime on the nicotinamide coenzyme and adenine nucleotide content of the rat myocardium and liver].
It has been shown in rat experiments that armin in doses that inhibit blood cholinesterase by 50 and more per cent lowers the content of nicotinamide coenzymes in the myocardium and liver of the animals, primarily at the expense of the diminution of the oxidized forms. In the rat liver, armin decreases the content of adenyl nucleotides, mainly at the expense of ATP. Dipyroxime prevents changes induced by armin, which is accompanied by partial reactivation of cholinesterase. It is suggested that in the mechanism of antidote action of dipyroxime, of importance is its normalizing effect on redox and energy processes in the body.
D000227:Adenine Nucleotides / Q000378:metabolism*; D000818:Animals; D001138:Armin / Q000494:pharmacology*; D002801:Cholinesterase Reactivators / Q000494:pharmacology*; D002802:Cholinesterases / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009243:NAD / Q000378:metabolism*; D009249:NADP / Q000378:metabolism*; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010091:Oximes / Q000494:pharmacology*; D051381:Rats; D014289:Trimedoxime / Q000494:pharmacology*
D000227:Adenine Nucleotides; D002801:Cholinesterase Reactivators; D009943:Organophosphorus Compounds; D010091:Oximes; D009243:NAD; D009249:NADP; D014289:Trimedoxime; D002802:Cholinesterases; D001138:Armin
Vliianie armina i depiroksima na soderzhanie nikotinamidnykh kofermentov i adenilovykh nukleotidov v miokarde i pecheni.