The effect of cholinergic antagonists on a central response to nicotine.
Mecamylamine and hexamethonium antagonize the prostration response of rats to centrally-administered nicotine; decamethonium and d-tubocurarine are less effective. physostigmine does not elicit the response. Nicotine's central cholinergic effect thus may contribute to but does not fully account for its action.
D000818:Animals; D003650:Decamethonium Compounds / Q000494:pharmacology; D006584:Hexamethonium Compounds / Q000494:pharmacology; D006801:Humans; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology; D009068:Movement / Q000187:drug effects*; D009538:Nicotine / Q000494:pharmacology*; D010276:Parasympatholytics / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011950:Receptors, Cholinergic / Q000187:drug effects; D014403:Tubocurarine / Q000494:pharmacology
D003650:Decamethonium Compounds; D006584:Hexamethonium Compounds; D010276:Parasympatholytics; D011950:Receptors, Cholinergic; D008464:Mecamylamine; D009538:Nicotine; D014403:Tubocurarine