Experimentally induced complement and immunoglobulin deposition along the basement membrane zone (BMZ) and in dermal blood vessels.
Clinically normal forearm skin of ten subjects was abraded and biopsied at 24 h and at 5 and 10 day intergvals. Biopsy specimens were processed for routine histology and direct immunofluorescence. All ten subjects showed deposition of complement either in the blood vessels and/or along the basement membrane zone 24 h after injury. IgM deposition was found along the BMZ in two patients and in the blood vessels of the papillary dermis in one patient. This immunofluorescence staining was considered a non-specific reaction pattern to injury.
D001485:Basement Membrane / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology*; D005337:Fibrin / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology*; D012867:Skin / Q000098:blood supply / Q000276:immunology*; D013997:Time Factors
D007136:Immunoglobulins; D005337:Fibrin; D003165:Complement System Proteins