title: Identification and distribution of phenylacetic acid in the brain of the rat.
abstract: Phenylacetic acid, the major metabolite of phenylethylamine, has been identified and quantitated in rat brain regions by capillary column high-resolution gas chromatography mass spectrometry. Its distribution is heterogeneous and correlates with that of phenylethylamine. The values obtained were (ng/g +/- SEM): whole brain, 31.2 +/- 2.7; caudate nucleus, 64.6 +/- 6.5; hypothalamus, 60.1 +/- 7.4; cerebellum, 31.3 +/- 2.9; brainstem, 33.1 +/- 3.3, and the "rest," 27.6 +/- 3.0.
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D001933:Brain Stem / Q000032:analysis; D002421:Caudate Nucleus / Q000032:analysis; D002531:Cerebellum / Q000032:analysis; D007031:Hypothalamus / Q000032:analysis; D008297:Male; D013058:Mass Spectrometry; D010648:Phenylacetates / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
chemical_list: D010648:Phenylacetates; C025136:phenylacetic acid