Role of renal nerves, angiotensin II, and prostaglandins in the antinatriuretic response to acute hypercapnic acidosis in the dog.
Although clinical studies suggest that chronic hypercapnic acidosis may be associated with renal sodium retention, little information is available on the effect of acute hypercapnic acidosis on renal sodium excretion. We, therefore, increased PCO2 from 23 to 74 mm Hg in anesthetized dogs and observed a marked antinatriuresis as absolute sodium excretion (235 to 60 muEq/min, P less than 0.001) and fractional excretion of sodium (4.0 to 1.2 %, P less than 0.02) decreased significantly. This decrease in sodium excretion occurred independent of consistent changes in renal perfusion pressure, PO2, glomerular filtration rate, renal blood flow, extraction of P-aminohippuric acid, and filtration fraction. The antinatriuretic response to acute hypercapnic acidosis could be attenuated significantly by surgical renal denervation, intrarenal phenoxybenzamine, and by intrarenal infusion of 1-sarcosine,8-glycine angiotensin II. Administration of 10 mg/kg indomethacin enhanced the antinatriuretic response to hypercapnic acidosis in denervated kidneys. These results suggest that renal alpha-adrenergic nerves and the renal angiotensin system result in an antinatriuretic effect during acute hypercapnic acidosis. Renal prostaglandins or related substances may serve to attenuate this antinatriuretic response.
D000138:Acidosis / Q000150:complications* / Q000503:physiopathology; D000208:Acute Disease; D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D005260:Female; D005374:Filtration; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006935:Hypercapnia / Q000150:complications / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply / Q000294:innervation*; D008297:Male; D009318:Natriuresis; D010643:Phenoxybenzamine / Q000494:pharmacology; D011453:Prostaglandins / Q000378:metabolism*; D012964:Sodium / Q000652:urine
D011453:Prostaglandins; D010643:Phenoxybenzamine; D000804:Angiotensin II; D012964:Sodium