title: A candidate reference method for uric acid in serum. II. Interlaboratory testing.
abstract: We describe the interlaboratory testing of a candidate Reference Method (Part I) for uric acid in serum. The method is based on the ultrasound spectrophotometric quantitation of uric acid before and after incubation with uricase. A comprehensive investigation involving 12 laboratories was organized to document the transferability, intra- and interlaboratory precision, and general reliability of the candidate Reference Method. The interlaboratory CV with this method was about 2 to 6% for uric acid concentrations ranging from 0.12 to 0.60 mmol/L. The results detailed here demonstrate that the method can be successfully duplicated among different laboratories.
mesh_terms: D005069:Evaluation Studies as Topic; D006801:Humans; D012015:Reference Standards; D013056:Spectrophotometry, Ultraviolet; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid