Angiotensin inhibits action of vagus nerve at the heart.
The effects of angiotensin II and angiotensin III (Des-Asp angiotensin II) on cardiac vagal nerve endings were studied in intact dogs and in isolated guinea-pig atria. Decreases in heart rate evoked by electrical stimulation of the peripheral end of the cut vagus were attenuated in the presence of angiotensin II and angiotensin III.
D000109:Acetylcholine / Q000494:pharmacology; D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000805:Angiotensin III / Q000494:pharmacology*; D000818:Animals; D003864:Depression, Chemical; D004285:Dogs; D004558:Electric Stimulation; D006168:Guinea Pigs; D006321:Heart / Q000294:innervation*; D006339:Heart Rate / Q000187:drug effects; D009411:Nerve Endings / Q000187:drug effects; D014630:Vagus Nerve / Q000187:drug effects*
D000804:Angiotensin II; D000805:Angiotensin III; D000109:Acetylcholine