The quantitative structure-activity relationship of rifamycin B amide and hydrazide toxicity in mice.
Quantitative structure-activity relationships (QSAR) are developed for the acute toxicity of a number of rifamycin B amides and hydrazides in mice. The equations indicate a parabolic dependence of toxicity on the partition coefficient. Two related compounds, rifamycin SV and rifamycin B, were included with the amides in a more general correlation. The latter equation was used to predict the toxicity of rifampicin, suggesting that this relationship may be of general use for the prediction of rifamycin toxicity.
D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007928:Lethal Dose 50; D051379:Mice; D012294:Rifamycins / Q000633:toxicity*; D013329:Structure-Activity Relationship
D012294:Rifamycins; C023808:rifamycin SV