title: Release and vasoactive actions of catecholamines during inhibition of prostaglandin synthesis in normal man.
abstract: To assess the effect of prostaglandin inhibition upon the vasoactive actions of endogenous and exogenous catecholamines in healthy man, indomethacin (150 mg/day for 3 days) was administered to six healthy men in the sodium-repleted state. Pretreatment with indomethacin did not interfere with the response of blood pressure and pulse rate to orthostasis (10 minutes), a cold pressor test (2 minutes), and the intravenous (i.v.) administration of norepinephrine (NE) (50, 100, and 200 ng kg-1 min-1). Basal plasma concentrations of epinephrine (E) and NE as well as the concentrations of E during orthostasis and cold pressor test remained uninfluenced by pretreatment with indomethacin. While the release of NE during orthostasis appeared to be suppressed in the indomethacin-treated state, it was unchanged during the cold pressor test. These results indicate that inhibition of endogenous prostaglandin synthesis may suppress the release of NE, but does not have a major impact on the vasoactive actions of endogenous and exogenous catecholamines in normal men.
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003080:Cold Temperature; D004837:Epinephrine / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000097:blood* / Q000494:pharmacology; D011187:Posture; D011448:Prostaglandin Antagonists; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D011448:Prostaglandin Antagonists; D009638:Norepinephrine; D007213:Indomethacin; D004837:Epinephrine