Biology of local heat therapy for cancer.
Successful cancer therapy must selectively destroy tumor tissue while sparing the host's normal tissues. Local heat treatment can have such a selective effect because abnormalities in tumor blood vessels supply less oxygen to heat-stressed tumor cells and are less efficient in cooling tumor tissue by blood perfusion.
D000818:Animals; D002478:Cells, Cultured; D004285:Dogs; D006358:Hot Temperature / Q000627:therapeutic use*; D006801:Humans; D006830:Hydralazine / Q000627:therapeutic use; D008722:Methods; D009369:Neoplasms / Q000098:blood supply / Q000473:pathology / Q000628:therapy*; D010101:Oxygen Consumption; D012039:Regional Blood Flow / Q000187:drug effects
D006830:Hydralazine