Comparison of diflorasone diacetate and betamethasone dipropionate ointment in the treatment of psoriasis.
In this double-blind study, 100 patients with mild, moderate, or severe thick lesion psoriasis, characterized as acute, subacute, or chronic, were treated with either diflorasone diacetate ointment 0.05% or betamethasone dipropionate ointment 0.05% twice a day for 3 weeks. Clinical evaluations were based on overall improvement and improvement in signs or symptoms of erythema, oedema, lichenification, induration, scaliness, excoriations, pruritus, and soreness. Results showed that both medications were effective and when patients were categorized according to initial lesion severity no statistically significant differences existed between treatment groups.
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001623:Betamethasone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003408:Cresols / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D004890:Erythema / Q000188:drug therapy; D005260:Female; D005938:Glucocorticoids; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments; D011565:Psoriasis / Q000175:diagnosis / Q000188:drug therapy*; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D003408:Cresols; D004338:Drug Combinations; D005938:Glucocorticoids; D009824:Ointments; C011175:betamethasone-17,21-dipropionate; D001623:Betamethasone; C014477:diflorasone