Comparison of serum bilirubin levels in humans and two monogastric animal species after a single administration of sulfisoxazole.
Administration of sulfonamides during periods of hepatobiliary failure or hepatic immaturity increases the toxic potential of unconjugated or indirect bilirubin. A small but statistically significant increase of indirect, or unconjugated bilirubin was noted in dogs after oral administration of sulfisoxazole (100 mg/kg). A similar increase was not observed in swine after oral or intravenous administration of sulfisoxazole (100 mg/kg) or in humans (approximately 28 mg/kg) after oral administration or in dogs (100 mg/kg) after intravenous administration. Total and conjugated bilirubin showed small but statistically significant increases and were significantly correlated in dogs after oral and intravenous administration of sulfisoxazole (100 mg/kg) and in swine after oral administration of sulfisoxazole (100 mg/kg). There was a significant negative correlation between conjugated and indirect bilirubin, while total bilirubin increased in dogs after oral and intravenous administration of sulfisoxazole. These data illustrate a difference in species and administration route when attempting to assess the potential toxicity of bilirubin.
D000284:Administration, Oral; D000328:Adult; D000818:Animals; D001663:Bilirubin / Q000097:blood*; D004285:Dogs; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D013045:Species Specificity; D013444:Sulfisoxazole / Q000009:adverse effects*; D013552:Swine
D013444:Sulfisoxazole; D001663:Bilirubin