Cerebral malaria in inbred mice. I. A new model and its pathology.
Plasmodium berghei ANKA was tested for its usefulness as a model for cerebral malaria in inbred mouse strains A, A2G, A/J, C57L, SJL/J and SWR. A suitable model was obtained in A or A/J strain mice. Mortality was 100% after five to eight days with brain haemorrhages occurring terminally. The histopathology is described. The model was stable after six blood passages at 5- to 7-day intervals. Chloroquine abolished the haemorrhages and no intercurrent viral or blood protozoal infections were detected.
D000818:Animals; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D007668:Kidney / Q000473:pathology; D008288:Malaria / Q000473:pathology*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008815:Mice, Inbred Strains; D010962:Plasmodium berghei