[The significance of LP-X cholesterol in the differential diagnosis of cholestasis (author's transl)].
The aim of this study was to investigate whether quantification of Lipoprotein X (LP-X) through its cholesterol moiety is advantageous in the differential diagnosis of obstructive jaundice. In the case of mechanic cholestasis, LP-X cholesterol never exceeds 22% of the total serum cholesterol. Lipoprotein-X cholesterol exceeded 70 mg/dl in the plasma of 85% of all cases of acute hepatitis. The combination of lipoprotein with the activities of alkaline phosphatase and GPT allows the recognition of almost 80% of cases acute hepatitis and thereby excludes all other causes of obstructive jaundice. In addition, 84% of all patients investigated can be correctly classified using a combination of LP-X with classical parameters for cholestasis. The concentration of LP-X cholesterol alone apparently is as powerful as the usually used clinical chemical parameters. A combination of lipoprotein and the classical parameters allows a better differentiation of cholestatic liver disease with regard to the underlying cause as it is possible with each group of parameters alone.
D000410:Alanine Transaminase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002779:Cholestasis / Q000175:diagnosis*; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL; D006505:Hepatitis / Q000175:diagnosis; D006801:Humans; D008073:Lipoprotein-X / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008099:Liver / Q000201:enzymology; D008103:Liver Cirrhosis / Q000175:diagnosis; D008113:Liver Neoplasms / Q000175:diagnosis
D008076:Cholesterol, HDL; D008073:Lipoprotein-X; D008075:Lipoproteins, HDL; C034440:lipoprotein-X cholesterol; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase
Die Bedeutung des Lipoprotein-X-Cholesterins in der Differentialdiagnostik der Cholestase.