Influence of a low protein diet on salicylate-induced damage in mice.
The influence of a low protein diet (8%) during pregnancy on the teratogenic potential of sodium salicylate was studied in NMRI mice. Sodium salicylate was given intramuscularly as a single dose of 250 or 500 mg/kg on gestation day 9 or 17. Reduced fetal weight was the only adverse effect of the low protein diet. Following the teratogenic dose of 500 mg/kg, more skeletal malformations were found in fetuses of deficient mothers than of those on a standard diet. An increased incidence of fetal death was demonstrated on gestation day 17 even at the subteratogenic dose of 250 mg/kg.
D000014:Abnormalities, Drug-Induced / Q000473:pathology; D000818:Animals; D001835:Body Weight; D001842:Bone and Bones / Q000002:abnormalities*; D005260:Female; D005333:Fetus / Q000473:pathology; D005865:Gestational Age; D051379:Mice; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology; D011488:Protein Deficiency / Q000150:complications*; D012980:Sodium Salicylate / Q000633:toxicity*
D012980:Sodium Salicylate