Periaqueductal gray matter involvement in the muscimol-induced decrease of morphine antinociception.
Microinjections of muscimol, a GABA receptor agonist, into the periaqueductal gray matter (PAG) counter-acted the antinociceptive effect of morphine in rats, as measured by the "tail-flick" method. Muscimol's effect was partially reversed by bicuculline.
D000698:Analgesia; D000818:Animals; D002535:Cerebral Aqueduct / Q000502:physiology*; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors*; D009118:Muscimol / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D010080:Oxazoles; D009118:Muscimol; D009020:Morphine