GLC analysis of trifluoperazine in human plasma.
This report describes a sensitive gas chromatographic procedure for the measurement of trifluoperazine in human plasma. Trifluoperazine was extracted into heptane-2-propanol by a two-step procedure and analyzed directly without derivatization. Prochlorperazine was employed as an internal standard because its structural and extraction characteristics were similar to trifluoperazine. The use of a nitrogen detection system reduced the number of interfering peaks. The within-day coefficient of variation in the methods, over a 0.2-20-ng/ml concentration range was 9.4%.
D002849:Chromatography, Gas / Q000379:methods; D006801:Humans; D012559:Schizophrenia / Q000188:drug therapy; D014268:Trifluoperazine / Q000097:blood* / Q000627:therapeutic use
D014268:Trifluoperazine