title: Breakdown and reestablishment of blood-aqueous barrier with implant surgery.
abstract: Preoperative and serial postoperative anterior chamber fluorophotometry was performed after oral administration of fluorescein sodium in patients undergoing extracapsular cataract extraction combined with intraocular lens implantation. In placebo-treated eyes, the blood-aqueous barrier was reestablished at three months after surgery. The administration of topical indomethacin before and after surgery markedly decreased aqueous fluorescein concentration, and the blood-aqueous barrier was reestablished within five weeks. Because all patients were given sub-Tenon's injection of steroids immediately after surgery and intensive topical steroid therapy postoperatively, the effect of topical indomethacin was additive to or synergistic with steroids. The addition of topical indomethacin caused a small but statistically significant increase in the postoperative intraocular pressure; this effect lasted nine weeks.
mesh_terms: D000287:Administration, Topical; D001082:Aqueous Humor / Q000502:physiology*; D001790:Blood Physiological Phenomena; D004357:Drug Synergism; D005452:Fluoresceins / Q000008:administration & dosage; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology / Q000627:therapeutic use*; D007267:Injections; D007429:Intraocular Pressure / Q000187:drug effects; D007910:Lenses, Intraocular; D011897:Random Allocation; D013256:Steroids / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D005452:Fluoresceins; D013256:Steroids; D007213:Indomethacin