[Cytological study of the action of imidazoles on Candida albicans (author's transl)].
Imidazoles (econazole, miconazole, ketoconazole, isoconazole, 10(-3) M.) used to treat intact cells and sphaeroplasts of Candida albicans caused small lesions in the cell wall, but none or minor less in the cytoplasmic membrane. On the other hand, clotrimazole, in the same conditions, caused important lesions in the cytoplasmic membrane and none on the cell wall. Miconazole, econazole and isoconazole inhibited the release of sphaeroplasts from treated intact yeast cells.
D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000648:ultrastructure; D002462:Cell Membrane / Q000187:drug effects; D002473:Cell Wall / Q000187:drug effects; D003022:Clotrimazole / Q000494:pharmacology; D004464:Econazole / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D008825:Miconazole / Q000494:pharmacology; D008855:Microscopy, Electron, Scanning; D013104:Spheroplasts / Q000187:drug effects
D000935:Antifungal Agents; D007093:Imidazoles; D004464:Econazole; D008825:Miconazole; D003022:Clotrimazole
Etude cytologique de l'action des imidazoles sur Candida albicans.