[Effect of levorin on the activity of facilitated diffusion systems in murine Ehrlich cancer cells].
Five-minute incubation of the cells of Ehrlich's mouse carcinoma with levorin in a concentration of 0.25 microgram/ml resulted in a release of 30% of K+ and 40-50% suppression of active transport of neutral amino acids. No changes in incorporation of nitrous compounds, nucleosides and cyclophosphamide, an antitumor drug transported by the systems of facilitated diffusion were observed under the same conditions.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D002174:Candicidin / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D003520:Cyclophosphamide / Q000378:metabolism / Q000627:therapeutic use; D004058:Diffusion; D066298:In Vitro Techniques; D051379:Mice; D009705:Nucleosides / Q000378:metabolism
D000596:Amino Acids; D000935:Antifungal Agents; D009705:Nucleosides; D002174:Candicidin; D003520:Cyclophosphamide
Deistvie levorina na aktivnost' nekotorykh sistem oblegchennoĭ diffuzii v kletkakh myshinogo raka Erlikha.