The influence of asphyxia on fetal lidocaine toxicity.
Local anesthetics have played an important role in modern obstetrics. Although reasonably safe, these agents have been shown to have detrimental effects in some fetuses. In the present study we examined the influence of acute asphyxia in the fetal lamb on the distribution and cerebral uptake of maternally infused lidocaine. Results demonstrate that asphyxia is associated with higher lidocaine concentrations in the fetal plasma, increased presentation of the drug to the fetal brain, and increased cerebral lidocaine uptake. These findings underscore the importance of evaluation of fetal status when considering the risks and benefits of maternal drug use.
D000818:Animals; D001237:Asphyxia / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D005260:Female; D005316:Fetal Distress / Q000378:metabolism*; D005311:Fetal Hypoxia / Q000378:metabolism*; D008012:Lidocaine / Q000378:metabolism* / Q000633:toxicity; D008099:Liver / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012039:Regional Blood Flow / Q000187:drug effects; D012756:Sheep
D008012:Lidocaine