[Synthesis of 2-methoxynaphthalene derivatives as potential anti-inflammatory agents].
Compounds having 2-methoxynaphthalene as their parent nucleus were synthesized and evaluated for antiinflammatory effect according to the carrageenin paw edema method in rats. The synthetic routes for the preparation of isomeric 1,2- and 2,6-disubstituted derivatives are described. Replacement of the alpha-methylacetic moiety in naproxen by 4-hydroxybutyric acid side chain did not cause loss of activity.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D002351:Carrageenan; D004487:Edema / Q000188:drug therapy; D008297:Male; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D009281:Naphthalenes; D002351:Carrageenan
Sintesi di derivati della 2-metossinaftalina come potenziali antiinfiammatori.