Polyamines inhibit the protein kinase 380--catalyzed phosphorylation of eukaryotic initiation factor 2 alpha.
Polyamines putrescine, spermidine, and spermine specifically inhibit the PK 380--catalyzed phosphorylation of eukaryotic initiation factor 2 alpha (eIF-2 alpha). Since te PK 380--dependent phosphorylation of eIF-2 alpha inhibits the initiation or protein synthesis, the possibility exists that the polyamines enhance protein synthesis by inhibiting the phosphorylation of eIF-2 alpha by PK 380.
D000302:Adrenal Cortex / Q000201:enzymology / Q000502:physiology*; D000818:Animals; D002417:Cattle; D002474:Cell-Free System; D010442:Peptide Chain Initiation, Translational / Q000187:drug effects; D010448:Peptide Initiation Factors / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism; D010766:Phosphorylation; D011073:Polyamines / Q000494:pharmacology*; D047428:Protein Kinase Inhibitors
D010448:Peptide Initiation Factors; D010750:Phosphoproteins; D011073:Polyamines; D047428:Protein Kinase Inhibitors