beta, gamma-Peroxy analogs of adenosine and guanosine triphosphate: synthesis and biological activity.
Extended analogs of adenosine triphosphate (ATP) and guanosine triphosphate (GTP), in which a peroxide bridge replaces the terminal bridge-oxygen of the triphosphate chain, have been synthesized. The ability of beta, gamma-peroxy-ATP to inhibit or substitute for ATP in representative enzyme systems and that of beta, gamma-peroxy-GTP, for FTP in protein synthesis was tested.
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D007700:Kinetics; D010545:Peroxides; D014176:Protein Biosynthesis / Q000187:drug effects; D013329:Structure-Activity Relationship
D010545:Peroxides; D006160:Guanosine Triphosphate; D000255:Adenosine Triphosphate