Comparative effects of estrogens and prolactin on nigral and striatal GAD activity.
The comparative effects of a 10 day estrogen treatment and estrogen independent hyperprolactinemia on nigral and striatal glutamic acid decarboxylase (GAD, EC 4.1.1.15) activity were investigated in male rats. Data obtained show that estrogen treatment decreases GAD activity in substantia nigra, while an increase was observed in conditions of hyperprolactinemia induced by adenohypophysis homograft or acute and chronic sulpiride injection. The possibility of an opposite modulation of strio-nigral GABAergic system by estrogens and prolactin is suggested.
D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology*; D004958:Estradiol / Q000494:pharmacology*; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D008297:Male; D011388:Prolactin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects / Q000201:enzymology*; D013469:Sulpiride / Q000494:pharmacology
D004958:Estradiol; D013469:Sulpiride; D011388:Prolactin; D002262:Carboxy-Lyases; D005968:Glutamate Decarboxylase