Effects of topical 10% ascorbate solution on established corneal ulcers after severe alkali burns.
When established corneal ulcers induced by alkali burning were treated with 10% ascorbate drops, no perforation occurred, in contrast to a 25% incidence in the control group. If perforations and descemetoceles were grouped together, these difference became insignificant (i.e., 14.2% ascorbate-treated vs. 25% control). Prolongation of descemetocele presence without perforation in the ascorbate-treated group indicated some therapeutic effect. We conclude that topical ascorbate does not substantially alter the outcome of established corneal ulcers.
D000287:Administration, Topical; D000468:Alkalies / Q000009:adverse effects; D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use*; D002057:Burns, Chemical / Q000150:complications*; D003320:Corneal Ulcer / Q000188:drug therapy* / Q000209:etiology; D005126:Eye Burns / Q000150:complications*; D011817:Rabbits
D000468:Alkalies; D001205:Ascorbic Acid