Possible involvement of the amygdaloid complex in morphine analgesia as studied by electrolytic lesions in rats.
The analgesic effects of morphine (5 mg/kg i.p.) were studied in biamygalectomized rats. (1) Using the tail-flick test neither withdrawal latencies nor morphine time-course and efficacy were affected by the lesions. (2) The threshold for vocalization to electrical stimulation of the tail was greatly increased in lesioned rats; however, statistical analysis revealed no significant change in the analgesic efficacy of morphine.
D000679:Amygdala / Q000502:physiology*; D000698:Analgesia; D000818:Animals; D004558:Electric Stimulation; D008297:Male; D009020:Morphine; D009068:Movement; D010146:Pain / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time; D013623:Tail / Q000503:physiopathology; D013997:Time Factors; D014828:Vocalization, Animal / Q000502:physiology
D009020:Morphine