Complementary role of reticuloendothelial and hepatobiliary imaging agents in the assessment of liver disease.
The merit of concomitant hepatic imaging with Tc-99m-sulfur colloid (SC) and Tc-99m-HIDA was examined in 40 patients with abnormal liver function tests. The studies were performed sequentially within a 2 to 5 day interval with 5 mCi each of SC or HIDA. Routine static images in all cases, and dynamic studies with HIDA in 15 patients, were graded and compared with the liver function tests and clinical diagnoses. Of the 40 patients, the images with SC showed an abnormality in 22 while HIDA images were abnormal in 38. Thirteen of 21 patients with hepatocellular diseases showed an abnormality of the SC images, and 20 of the same 21 patients had abnormal HIDA images. Abnormal HIDA images were more closely related to abnormal liver function tests. These results suggest that alterations of hepatic function reflected by abnormal liver function tests are better demonstrated with hepatobiliary imaging agents than with reticuloendothelial imaging agents, while either type of imaging agents will detect focal anatomic lesions.
D006801:Humans; D007098:Imino Acids; D008107:Liver Diseases / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D008111:Liver Function Tests; D011877:Radionuclide Imaging; D013455:Sulfur; D013667:Technetium; D019780:Technetium Tc 99m Lidofenin; D013671:Technetium Tc 99m Sulfur Colloid
D007098:Imino Acids; D013671:Technetium Tc 99m Sulfur Colloid; D019780:Technetium Tc 99m Lidofenin; D013455:Sulfur; D013667:Technetium