title: Microvascular response to angiography.
abstract: A controlled laboratory study using matched groups fo pure-bred Sprague-Dawley rats evaluated the histologic microvascular response to contrast angiography. The femoral vessels were studied by both light and transmission electron microscopy (TEM) following injection of the infrarenal aorta with Renografin-60 or saline at intervals from 2 hours to 56 days. None of the specimens studied showed significant cellular, interstitial, or intravascular injury. TEM demonstrated electron-dense particles which migrated from the vessel lumen into the endothelial cytoplasm and basal lamina and subsequently diffused back into the cytoplasm. This study demonstrates the absence of microvessel damage from a radiopaque contrast medium administered by techniques designed to parallel the clinical model.
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000009:adverse effects*; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000648:ultrastructure; D005268:Femoral Vein / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008866:Microsurgery; D011859:Radiography; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003287:Contrast Media