title: Influence of methionine on the mutation frequency in Salmonella typhimurium.
abstract: When reversion of some markers in S. typhimurium was tested, it was found that addition of methionine to test plates increased the revertant yields. Two assumptions were made: (1) the effect of methionine reflects the necessity of intensive synthesis of some protein(s) required for abolishing the deleterious effects and/or expressing the mutagenic effects induced by mutagens; (2) methionine influences the mutagenesis via the DNA methylation process.
mesh_terms: D005838:Genotype; D008715:Methionine / Q000378:metabolism / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009154:Mutation; D012486:Salmonella typhimurium / Q000187:drug effects*
chemical_list: D008715:Methionine