Flow measurement of blood radioactivity in animals.
In order to permit flow measurement of blood radioactivity in an animal after establishing extracorporeal circulation, counting cells were constructed of various plastic scintillator materials. The cell was placed in a liquid scintillation spectrometer replacing the sample vial. Stable and reproducible counting rates were obtained only with cells made of blue Altustipe plastic. The counting efficiency was 1.8%. Using this detection system, continuous records were produced of blood radioactivity in miniature pigs after administration of 14C-urethane and [14C]methyl-piperazinyl pyrazino benzoxazepine maleate.
D000818:Animals; D002250:Carbon Radioisotopes; D006993:Hypnotics and Sedatives / Q000097:blood; D007700:Kinetics; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012588:Scintillation Counting / Q000379:methods*; D013552:Swine; D014520:Urethane / Q000097:blood
D002250:Carbon Radioisotopes; D006993:Hypnotics and Sedatives; D004364:Pharmaceutical Preparations; D014520:Urethane