Aspirin-induced asthma in children.
Aspirin-sensitive asthma is not well documented in children. It may present as a triad of (1) allergic rhinitis, (2) nasal polyps and/or sinusitis and (3) bronchial asthma precipitated by aspirin. Four cases in children are presented. The pathophysiology probably involves the biosynthesis of prostaglandins.
D000107:Acetylation; D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced* / Q000175:diagnosis / Q000209:etiology; D002648:Child; D003165:Complement System Proteins; D003240:Connective Tissue Diseases / Q000150:complications; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D009298:Nasal Polyps / Q000150:complications; D011453:Prostaglandins / Q000096:biosynthesis; D012220:Rhinitis / Q000150:complications; D012852:Sinusitis / Q000150:complications; D013645:Tartrazine
D000893:Anti-Inflammatory Agents; D011453:Prostaglandins; D003165:Complement System Proteins; D013645:Tartrazine; D001241:Aspirin