Mebendazole therapy of enteral trichinellosis.
Mebendazole was highly effective against the helminth parasite Trichinella spiralis in mice subjected to a 3-day course of treatment during the enteral phase of experimental trichinellosis. When treatment began 72 hr after the mice were inoculated with parasites, the number of adult worms recovered from the host intestine was greatly reduced by twice-daily oral administration of 7.5 mg of mebendazole per kilogram of body weight.
D000284:Administration, Oral; D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D007422:Intestines / Q000469:parasitology; D008463:Mebendazole / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D013997:Time Factors; D014234:Trichinella / Q000302:isolation & purification; D014235:Trichinellosis / Q000188:drug therapy*
D001562:Benzimidazoles; D008463:Mebendazole