Infantile neuroblastoma presenting with cutaneous blanching nodules.
An 8-week-old girl was seen because of firm, blue cutaneous nodules. A biopsy showed neuroblastoma. When rubbed, the nodules blanched and were surrounded with a halo of erythema. She had Horner's syndrome, hepatomegaly, bone marrow and shaft invasion, and a high thoracic mass with signs of spinal cord compression. Blanching cutaneous nodules are a unique finding in neuroblastoma and may be the first sign of this disease.
D005260:Female; D006801:Humans; D007223:Infant; D008479:Mediastinal Neoplasms / Q000473:pathology*; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000473:pathology* / Q000556:secondary; D012867:Skin / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology / Q000556:secondary*