title: [Ultrastructural lung changes in experimental thermal injury].
abstract: The dynamics of microcirculatory changes in the alveolar wall and the state of small and large alveolar cells were studied by electron microscopy at 1, 7, 14, and 30 days after flame burns of the IIIB degree on the area of 18% of the body surface of 23 rabbits. The thermal trauma was found to cause acute disorders of microcirculation consisting of aggregations of formed elements of the blood, microthrombosis, emergence of fatty emboli, leukostasis, erythrocyte diapedesis, and leukocyte migration into the alveolar cavity. Capillary endothelium first showed signs of increased transcapillary metabolism and then dystrophic changes of the cells up to focal lysis of the cytoplasm with the exposure of basal membrane combined with dystrophic changes of the alveolar cells. One month after the trauma, microsclerosis of the alveolar walls as well as signs of disorder in cell differentiation were found.
mesh_terms: D000818:Animals; D002056:Burns / Q000473:pathology*; D003289:Convalescence; D008168:Lung / Q000098:blood supply / Q000648:ultrastructure*; D008833:Microcirculation / Q000648:ultrastructure; D011650:Pulmonary Alveoli / Q000648:ultrastructure; D011817:Rabbits; D013997:Time Factors
vernacular_title: Ul'trastrukturnye izmeneniia legkikh pri termicheskoĭ travme v éksperimente.