title: Genes involved in the control of nuclear fusion during the sexual cycle of Saccharomyces cerevisiae.
abstract: Mutants of Saccharomyces cerevisiae defective for nuclear fusion have been isolated. Their mutations have been characterized by meiotic analysis, dominance-recessivity and complementation. Twelve of the mutations are allelic to the previously described kar 1-1; five affect a second gene designated KAR 2 and three affect a third gene designated KAR 3. There is evidence suggesting that other two mutants are affected in a gene different from the three mentioned. Mutations in KAR 1 and KAR 2 genes are recessive and do not cause obvious effects other than the failure of the karyogamy. Mutations in KAR 3 are semidominant and do cause pleiotropic effects affecting both a mitosis and meiosis.
mesh_terms: D002459:Cell Fusion; D002467:Cell Nucleus / Q000502:physiology; D002874:Chromosome Mapping; D005799:Genes, Dominant; D005816:Genetic Complementation Test; D009024:Morphogenesis; D009154:Mutation; D012098:Reproduction; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology*