title: Clinical laboratory evaluations of seven heartworm infected beagles: during disease development and following treatment.
abstract: Clinical laboratory evaluations were performed in 7 beagles for 12 months following experimental infection with Dirofilaria immitis and for 14 months following adulticide and microfilaricide treatment. Few abnormalities were detected. A mild basophilia and thrombocytopenia developed late during the year of infection and after arsenical treatment there were transient increases in eosinophils, SGPT, and SAP. Coagulation and blood gas studies were normal. The minimal changes were attributed to either: (1) the one year infection with 50 infective larvae was an insufficient insult or (2) an idiosyncrasy in the host-parasite relationship is required in order to produce marked alterations in clinical laboratory evaluations.
mesh_terms: D000818:Animals; D001148:Arsenamide / Q000494:pharmacology / Q000627:therapeutic use; D004183:Dirofilaria immitis / Q000187:drug effects; D004184:Dirofilariasis / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D004225:Dithiazanine / Q000494:pharmacology / Q000627:therapeutic use; D004283:Dog Diseases / Q000097:blood* / Q000188:drug therapy; D004285:Dogs; D005369:Filaricides / Q000494:pharmacology / Q000627:therapeutic use; D013773:Tetramisole / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D005369:Filaricides; D004225:Dithiazanine; D013773:Tetramisole; D001148:Arsenamide