Studies of clonogenic human tumor stem cells.
In vitro tissue culture methods for cloning human tumor cells from fresh biopsy samples appear to provide a simple yet quantitative approach to study the biology and chemosensitivity of neoplastic cells which are likely to be responsible for micrometastasis and tumor progression in vivo. Use of this assay technique may provide a useful empirical approach to improve adjuvant therapy of cancer.
D001706:Biopsy; D002478:Cells, Cultured; D002999:Clone Cells; D003114:Colony-Forming Units Assay; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology*