[Intracoronary thrombolytic treatment in the acute phase of myocardial infarction (author's transl)].
Thrombolysis by intracoronary injection of streptokinase was attempted in 18 patients with recent myocardial infarction. Streptokinase was administered by continuous i.v. infusion or by repeated injections to a maximal total dose of 250 000 units. Complete recanalization was obtained in 13 out of 16 patients with total occlusion of one vessel confirmed by angiography of the coronary arteries. Pain was relieved in 12 of these 13 patients and there was immediate and significant reduction of the lesion current in 9. The treatment was well tolerated. Arrhythmias in an usually minor form (ventricular ectopy) may occur during thrombolysis. No haemorrhage has been reported. There is no systemic fibrolysis in most cases.
D000208:Acute Disease; D000368:Aged; D003326:Coronary Circulation / Q000187:drug effects; D003331:Coronary Vessels; D006801:Humans; D007263:Infusions, Parenteral; D007269:Injections, Intra-Arterial; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D013300:Streptokinase / Q000008:administration & dosage*
D013300:Streptokinase
Traitement thrombolytique par voie coronarienne directe à la phase aiguë de l'infarctus du myocarde.