title: In vivo effect of adenosine on adenine nucleotides and inorganic phosphate in rat blood.
abstract: The effect of adenosine and the time response on adenine nucleotide and Pi levels in rat blood was investigated. An increase in adenine nucleotide with a concomitant decrease in Pi concentration 30, 60, and 90 minutes after the nucleoside administration were observed. Though the 100 mg/Kg dose showed the highest effect on nucleotide concentration, the maximal response on Pi content was achieved with the 50 mg/Kg dose. The results are discussed at the light of previous data obtained in hepatocytes, and using as indicators the energy charge and the phosphorylation potential.
mesh_terms: D000227:Adenine Nucleotides / Q000097:blood*; D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects; D008297:Male; D010710:Phosphates / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D000227:Adenine Nucleotides; D010710:Phosphates; D000241:Adenosine