[Comparison of the results of gestagen therapy of cancer of the corpus uteri with a preliminary study of tumor cell culture sensitivity to the preparations].
The paper deals with a comparative study on the efficacy of adjuvant gestagen therapy of 61 patients with primary endometrial carcinoma. A control group of 219 patients did not receive hormones. In gestagen group, sensitivity to drugs was determined prior to therapy in 67 cell cultures of carcinoma. This provided a basis for a study of the meaning of a test of sensitivity to drugs which was carried out prior to therapy in order to select a suitable gestagen. Survival (2 years) was significantly higher in the group in which tumor sensitivity to chosen gestagen was determined in cell culture prior to treatment. Due to selection of suitable gestagen before therapy by means of tumors sensitivity test, a more pronounced clinical effect is obtained.
D000077713:17 alpha-Hydroxyprogesterone Caproate; D002478:Cells, Cultured; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000008:administration & dosage; D009640:Norethindrone / Q000008:administration & dosage; D009644:Norgestrel / Q000008:administration & dosage; D045167:Progesterone Congeners / Q000627:therapeutic use*; D014594:Uterine Neoplasms / Q000188:drug therapy*
D006908:Hydroxyprogesterones; D045167:Progesterone Congeners; D000077713:17 alpha-Hydroxyprogesterone Caproate; D009644:Norgestrel; D009640:Norethindrone
Sopostavlenie rezul'tatov gestagennoĭ terapii raka tela matki s predvaritel'nym issledovaniem chuvstvitel'nosti kletochnoĭ kul'tury opukholi k preparatam.