A study of the inheritance pattern of Romano-Ward syndrome. Prolonged Q-T interval, syncope, and sudden death.
Romano-Ward syndrome consists of attacks of syncope, possible sudden death, accompanied by prolonged Q-T interval on ECG. We carried out HLA antigen typing of a family of 16 members having ten cases of Romano-Ward syndrome. All the ten cases had the common HLA haplotype of A9-Bw54, while the six not showing the symptoms did not have A9-Bw54 haplotype. The genes of this syndrome, considered to be inherited through the autosomal dominant patterns, are assumed to have a close linking to the major histocompatibility complex on the short arm of chromosome number 6.
D000328:Adult; D002648:Child; D002675:Child, Preschool; D003645:Death, Sudden; D004562:Electrocardiography; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D006331:Heart Diseases / Q000150:complications / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D013575:Syncope / Q000209:etiology / Q000235:genetics*; D013577:Syndrome
D006680:HLA Antigens