title: Investigation, with the Salmonella/microsome test, of psychopharmaceuticals used in meat production.
abstract: Azaperone, acepromazine, xylazine and diazepam were tested for mutagenic activity. To screen these veterinary drugs we used the Salmonella/microsome test on 5 histidine-auxotrophic strains, with and without metabolic activation. Azaperone and xylazine were found to be weakly mutagenic.
mesh_terms: D000075:Acepromazine / Q000494:pharmacology*; D000818:Animals; D001376:Azaperone / Q000494:pharmacology*; D001711:Biotransformation; D002090:Butyrophenones / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology*; D005511:Food Handling; D008460:Meat; D008862:Microsomes, Liver / Q000378:metabolism*; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects; D013843:Thiazines / Q000494:pharmacology*; D014991:Xylazine / Q000494:pharmacology*
chemical_list: D002090:Butyrophenones; D009153:Mutagens; D013843:Thiazines; D001376:Azaperone; D014991:Xylazine; D000075:Acepromazine; D003975:Diazepam