Action of fragments of human parathyroid hormone on blood pressure in rats.
To investigate localization of the action on blood pressure in the peptide chain of parathyroid hormone (PTH), we determined the effect of seven fragments of human (h) PTH-(1-34) fragments on blood pressure in anesthetized rats. hPTH-(1-7) and -(28-34) fragments had no effect up to 1 X 10(-6) mole/kg. hPTH-(8-34), -(13-34), -(18-34), and -(23-34) fragments showed significant hypotensive activity. The decrease in the chain length lowered the hypotensive activity. The results indicate that some amino acids in position 23-34 are necessary for the hypotensive activity. This accords with the previous report suggesting that 5 amino acids in position 24-28 are essential. In addition hPTH-(8-34) and -(13-34) fragments showed initial transient hypertensive activities. hPTH-(1-13) fragment had only hypertensive action, suggesting that some amino acids in position 8-13 are necessary for hypertensive activity.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006801:Humans; D010281:Parathyroid Hormone / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats
D010281:Parathyroid Hormone; D010446:Peptide Fragments