Behavioral thermoregulation in rats during hyperthermia induced by lysergic acid diethylamide.
In free moving rats trained to press a bar to escape from radiant heat, lysergic acid diethylamide (LSD, 8-16 micrograms) produced a significant and dose-dependent increase of the bar-pressing rate when injected intraperitoneally. During the increase in the bar-pressing rate, the rectal temperature showed an increase and both the tail-skin and the ambient temperature selected decreased concomitantly. The results indicate that LSD-induced hyperthermia is not due to an upward setting of the thermostat but mediated through the action of LSD on the effector pathways in the rats.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001833:Body Temperature Regulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology*; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D008297:Male; D051381:Rats / Q000502:physiology*; D011919:Rats, Inbred Strains
D008238:Lysergic Acid Diethylamide