Studies on osteoporosis VI. Effect of human  and salmon calcitonin on experimental osteoporosis.
Neutron activation analysis was employed to determine total body calcium in C3H/St (Ha) female mice. Ninty-nine percent of total body calcium is in bone and loss of calcium was used as an index of osteoporosis. Heparin (500 U/kg B.I.D.) treatment for three months resulted in significant osteoporosis. Both human and salmon calcitonin (4 MRC U/Kg B.I.D.) prevented heparin induced osteoporosis. The results suggest that calcitonin may prevent pathological fractures in patients on anticoagulants and other osteoporosis inducing regimens.
D000818:Animals; D001842:Bone and Bones / Q000032:analysis; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000032:analysis; D005260:Female; D006493:Heparin / Q000633:toxicity; D006494:Heparin Antagonists; D006801:Humans; D051379:Mice; D008809:Mice, Inbred C3H; D009501:Neutron Activation Analysis; D010024:Osteoporosis / Q000378:metabolism / Q000517:prevention & control*; D012474:Salmon
D006494:Heparin Antagonists; D006493:Heparin; D002116:Calcitonin; D002118:Calcium