4CMB: investigation of activity in a mouse micronucleus test.
To study possible clastogenic effects of 4-chloromethylbiphenyl (4CMB), a mouse micronucleus test was performed (as part of the UKEMS genetic toxicology trial). Mice were given 4CMB by intraperitoneal injection, once daily for 5 consecutive days. Although the range of dosages employed included highly toxic or lethal doses, the frequency of micronucleated polychromatic erythrocytes in the bone marrow was not significantly greater in 4CMB-treated groups, than in control-group animals treated with the Tween 80 vehicle alone. Thus, in this test, 4CMB did not induce chromosomal damage resulting in micronucleus formation, in bone-marrow erythrocytes.
D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects / Q000502:physiology; D002467:Cell Nucleus / Q000187:drug effects*; D002699:Chlorambucil / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*
D001713:Biphenyl Compounds; D009153:Mutagens; D002699:Chlorambucil; C033487:4-chloromethylbiphenyl; D003520:Cyclophosphamide