Cholesterol and bile acid metabolism in hypertensive arteriolipidosis-prone rats (ALR).
Bile flow and biliary bile acids were analyzed in arteriolipidosis-prone rats (ALR), the hypertensive model for lipidemic arterial lesions with reactive hypercholesterolemia and compared to those in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). Bile flow and bile acid secretion decreased in the order of WKY, SHR and ALR. When labelled cholesterol was given intraperitoneally, the biliary radioactivity secretion was significantly slow in ALR in comparison with that in WKY. The decay of radioactive cholesterol in serum after the injection was also delayed in ALR. Our data suggest that the abnormality in bile flow, biliary bile acid secretion and/or cholesterol turnover to bile acids may be pathogenically related to reactive hypercholesterolemia noted in the ALR.
D000818:Animals; D001161:Arteriosclerosis / Q000150:complications / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism*; D001835:Body Weight; D002784:Cholesterol / Q000097:blood*; D002793:Cholic Acids / Q000096:biosynthesis; D003840:Deoxycholic Acid / Q000096:biosynthesis; D006973:Hypertension / Q000150:complications* / Q000378:metabolism; D008064:Lipidoses / Q000150:complications* / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood
D001647:Bile Acids and Salts; D002793:Cholic Acids; D014280:Triglycerides; D003840:Deoxycholic Acid; C010471:hyodeoxycholic acid; D002784:Cholesterol