title: EEG monitoring of focal lesions of the blood-brain barrier.
abstract: This paper presents a modified method for the EEG detection and monitoring of small focal blood-brain barrier (BBB) lesions. The method uses high dose IV penicillin (1.2 X 10(6) mu/kg) to produce a spike focus at BBB lesions, penicillin encephalopathy. The EEG is recorded and the epileptic spikes are counted by an automatic computer program. The computer produces an objective quantitative results. The method is verified empirically on traumatic and radiation BBB lesions.
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000528:radiation effects; D002415:Cats; D002540:Cerebral Cortex / Q000293:injuries* / Q000528:radiation effects; D004569:Electroencephalography / Q000379:methods*; D005071:Evoked Potentials / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D010400:Penicillin G; D011833:Radiation Injuries, Experimental / Q000175:diagnosis; D012640:Seizures / Q000139:chemically induced
chemical_list: D010400:Penicillin G