The prevention of cyclophosphamide-induced cystitis in mice by disulfiram.
Cyclophosphamide administered intraperitoneally to mice at a dose of 100 mg/kg caused a dose related increase in urinary bladder weight within 48 hours of treatment. Disulfiram effectively prevented cyclophosphamide-induced increase in bladder weight when disulfiram was administered by either the oral or intraperitoneal route. Disulfiram (125 mg/kg) was most effective when given within one hour of cyclophosphamide treatment. These results suggest that disulfiram, unlike other putative protectants, is effective when administered orally.
D000818:Animals; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors*; D003556:Cystitis / Q000139:chemically induced / Q000517:prevention & control*; D004221:Disulfiram / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects
D003520:Cyclophosphamide; D004221:Disulfiram