title: Cephalosporins: bridging the generation gap.
abstract: More than a dozen compounds are now available. Although very effective and generally safe, the cephalosporins are often misused. The second- and third-generation drugs have provided progressively wider spectra of activity, although none has surpassed the activity of cephalothin against beta-lactamase-producing staphylococci. Cefotaxime and moxalactam have been shown to be useful in meningitis, whereas most of their predecessors have shown poor penetration into the cerebrospinal fluid.
mesh_terms: D001424:Bacterial Infections / Q000188:drug therapy*; D002511:Cephalosporins / Q000009:adverse effects / Q000145:classification* / Q000627:therapeutic use; D006801:Humans
chemical_list: D002511:Cephalosporins