title: Unstimulated and amphetamine-stimulated release of endogenous noradrenaline and dopamine from rat brain in vivo.
abstract: The in vivo release rates of endogenous noradrenaline from the hypothalamus and dopamine from the caudate nucleus of the rat have been determined. Artificial CSF perfusates collected from a push-pull cannula inserted into specific areas of the brain were assayed for the amines by a sensitive radioenzymatic procedure. The release rates of noradrenaline and dopamine into artificial CSF perfusates were 38 +/- 6 and 46 +/- 6 pg/h (225 +/- 36 and 301 +/- 39 fmol/h), respectively; when 0.5 mM amphetamine was added to the CSF, the release rates of noradrenaline and dopamine increased to 176 +/- 50 and 1183 +/- 453 ph/h (1041 +/- 296 and 7732 +/- 2961 fmol/h), respectively.
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects; D002421:Caudate Nucleus / Q000378:metabolism*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003913:Dextroamphetamine; D004298:Dopamine; D009638:Norepinephrine