[Therapeutic effectiveness of tetanus antitoxins purified by nonspecific and immunochemical methods].
The treatment of experimental tetanus intoxication in 120 rabbits by the intrathecal injection of antitoxins revealed that the therapeutic effect was directly proportional to the dose of antitoxins, expressed in antitoxic units. The maximum effect (the survival rate 78.6%) was obtained by the injection of antitoxins purified on immunoadsorbents and containing no admixtures. The use of such antitoxins ensured the absence of postinjection complications, while commercial antitetanus serum "Diaferm-3" gave only 16.7% survival rate and produced the equal percentage of postinjection complications.
D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D005260:Female; D007120:Immunochemistry; D008297:Male; D011817:Rabbits; D013742:Tetanus / Q000628:therapy; D013743:Tetanus Antitoxin / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D013997:Time Factors
D013743:Tetanus Antitoxin
Terapevticheskaia éffektivnost' stolbniachnykh antitoksinov, ochishchennykh nespetsificheskimi i immunokhimicheskimi metodami.