Inhibitory effect of some esters of 4-hydroxy-5-nitro-4,5-dihydrothymine on the growth of tumor cells.
New analogs of 4-hydroxy-5-nitro-4,5-dihydrothymine, namely 4-acyloxy-5-nitro-4,5-dihydrothymines (where: acyl = acetyl, benzoyl, mono- and dichloroacetyl) were synthesized and tested for their toxicologic and antitumor effects on Ehrlich ascites tumor cells and Ehrlich solid tumor. Best results were found for the mono- and dichloroacetyl derivatives.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D007928:Lethal Dose 50; D051379:Mice; D013941:Thymine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity
D000970:Antineoplastic Agents; D013941:Thymine