Lymphadenoid structure induced by gold hypersensitivity.
An allergic sensitivity to gold earrings produced a lymphadenoid reaction with germinal centers in the dermis of the pierced earlobes of a 21-year-old woman, However, a patch test for 1% gold sodium thiomalate gave a long-lasting, clinically and histologically eczematous response. Electron microscopic and cytochemical observations showed that non-T lymphocytes and plasma cells were dominant in the dermal infiltrate of the lesions, whereas lymphocytes with convoluted nuclei (which were probably T cells) and monocytes invaded the epidermis in the patch test site. These findings suggest that continuous exposure of the dermis to gold in a sensitized person may induce a lymphadenoid cellular reaction different from the histologic findings seen after contact with the epidermis.
D000328:Adult; D003877:Dermatitis, Contact / Q000209:etiology* / Q000473:pathology; D005260:Female; D006046:Gold / Q000009:adverse effects*; D006801:Humans; D008221:Lymphoid Tissue / Q000473:pathology / Q000648:ultrastructure; D010032:Otitis Externa / Q000139:chemically induced* / Q000473:pathology
D006046:Gold