Distribution of 5-HT accumulating neurons in the rat brain. A radioautographic study after different modes of 3H-5-HT administration.
The use of different types of 3H-5 HT administration (intraventricular and subarachnoïdal injections) has allowed to detect, in addition to the well-known serotonergic neurons, new labelled neuronal cell bodies in various areas of the brain: nuclei pontis (lateralis and pars medialis), nucleus interfascicularis, nucleus paranigralis, nucleus tegmentalis laterodorsalis and among the cells of the locus coeruleus. Moreover, a preliminary study shows that, in the lenniscus medialis, nucleus interpreduncularis paramedialis and pontine nuclei, more than 50% of the labelled, presumably serotonergic cells are in direct contact with blood vessels, while in the raphe dorsalis and nucleus interpeduncularis dorsalis the percentage is only 20 to 25%. Possible implications of these findings are discussed in terms of the nature of labelled neurons and of their eventual physiological function.
D000818:Animals; D001345:Autoradiography / Q000379:methods; D001921:Brain / Q000033:anatomy & histology / Q000098:blood supply / Q000378:metabolism*; D002196:Capillaries / Q000294:innervation; D004027:Diencephalon / Q000378:metabolism; D005260:Female; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism; D008636:Mesencephalon / Q000378:metabolism; D009434:Neural Pathways / Q000033:anatomy & histology / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000648:ultrastructure; D011149:Pons / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012154:Reticular Formation / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin