75Se-methionine platelet survival studies: a proposal for a mathematical correction of the curve.
We studied platelet survival in 14 cardiac before heart valve replacement using 75Se-methionine 'cohort label'. The temporal variation of plasma and platelet activity was plotted by a continuous curve by means of a computerized interaction of the single points. Then we computed the plasmatic radioactivity fraction used daily for thrombopoiesis and made a subtraction of this aliquot from a experimental activity in the catabolic phase of the slope. Platelet life span obtained after this 'correction' is comparable with the values of random label using 51Cr.
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D002470:Cell Survival; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D007700:Kinetics; D008297:Male; D008433:Mathematics; D008715:Methionine / Q000378:metabolism*; D008875:Middle Aged; D011868:Radioisotopes; D012643:Selenium
D011868:Radioisotopes; D008715:Methionine; D012643:Selenium