[Evaluation of the safety, reactogenicity and antigenic activity of inactivated chromatographic influenza vaccine in school children].
To evaluate the safety, reactogenicity and immunogenicity of inactivated chromatographic influenza vaccine A(H3N2) produced by the Pasteur Research Institute of Epidemiology and Microbiology in Leningrad, children aged 7-15 years received the vaccine intradermally in doses of 114-228 IU, and 152 children received placebo. In this study inactivated influenza vaccine introduced parenterally to children aged 11-15 years in a dose of 228 IU proved to be nonreactogenic. The reactogenicity index of the preparation injected in a dose of 114 IU to children aged 7-10 years was 0.6%. Immunization in a single injection was accompanied by significant seroconversions in 87.5%-96.0% of children with the highly pronounced growth of antibody titers (21.1-34.6 times). The complex of clinico-laboratory tests showed the safety of this preparation for both age groups.
D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000276:immunology*; D001769:Blood / Q000187:drug effects; D002648:Child; D004341:Drug Evaluation; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D010919:Placebos; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology
D000914:Antibodies, Viral; D000956:Antigens, Viral; D007252:Influenza Vaccines; D010919:Placebos; D014613:Vaccines, Attenuated
Otsenka v nabliudeniiakh na detiakh shkol'nogo vozrasta bezvrednosti, reaktogennosti i antigennoĭ aktivnosti grippoznoĭ inaktivirovannoĭ khromatograficheskoĭ vaktsiny.