The effect of some precursor amino acids and enzyme inhibitors on the mouse striatal concentration of tyramines and homovanillic acid.
The parenteral administration of L-phenylalanine or p-tyrosine increases the mouse striatal concentration of p-tyramine, an effect that is enhanced by monoamine oxidase inhibition and reduced by an L-aromatic aminoacid decarboxylase inhibitor. Striatal m-tyramine was increased following administration of L-phenylalanine or m-tyrosine and enhanced further by monoamine oxidase inhibition. It was also observed that m-tyrosine is a better substrate for decarboxylation than p-tyrosine, and that p-tyrosine decarboxylation was blocked by NSD 1055, while that of m-tyrosine was enhanced. The results obtained indicate that both isomers of tyramine are formed in the mouse striatum by hydroxylation of L-phenylalanine to p- or m-tyrosine followed by decarboxylation by a specific decarboxylase; an alternative pathway could be first the decarboxylation of phenylalanine to beta-phenylethylamine, followed by its hydroxylation to p- or m-tyramine.
D000818:Animals; D001958:Brocresine / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism*; D008297:Male; D051379:Mice; D010293:Pargyline / Q000494:pharmacology; D010648:Phenylacetates / Q000378:metabolism*; D010649:Phenylalanine / Q000494:pharmacology*; D014439:Tyramine / Q000378:metabolism*; D014443:Tyrosine / Q000494:pharmacology*
D010648:Phenylacetates; D001958:Brocresine; D014443:Tyrosine; D010649:Phenylalanine; D010293:Pargyline; D006719:Homovanillic Acid; D014439:Tyramine