Familial idiopathic hypertrophic osteoarthropathy and cranial suture defects in children.
Three children with idiopathic hypertrophic osteoarthropathy and cranial suture defects are reported. The syndrome was recognized after birth and in the two oldest siblings, the cranial defects and subperiosteal bone formation resolved almost completely by age 4 and 6 years. The joint swelling and clubbing persisted and mild bone reabsorption of the distal phalanges became apparent at an older age. Two siblings and both parents had normal bone X-rays and no clubbing. This study confirms the association of cranial sutural defects and familial idiopathic hypertrophic osteoarthropathy.
D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging*; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005121:Extremities; D005260:Female; D006801:Humans; D008297:Male; D010004:Osteoarthropathy, Primary Hypertrophic / Q000000981:diagnostic imaging* / Q000235:genetics; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000000981:diagnostic imaging; D010375:Pedigree; D011859:Radiography; D012886:Skull / Q000002:abnormalities* / Q000000981:diagnostic imaging