[Seasonal characteristics of the action of morphine and naloxone on the dopamine response of Helix neurons].
Morphine (1 X 10(-5) M) depresses the dopamine responses of Helix neurons in the summer-autumn period. The depolarizing responses are depressed more powerfully than the hyperpolarizing ones. Naloxone (1 X 10(-5) M) has no effect on the dopamine responses but antagonizes the effect of morphine. In the winter-spring period, the morphine effects are less potent (P less than 0.02), while naloxone depresses the dopamine responses. The results show the plasticity of the opiate-neurotransmitter system and relationship of the latter with the functional status of the body (hibernation, activity).
D000818:Animals; D004298:Dopamine / Q000494:pharmacology*; D004347:Drug Interactions; D006372:Helix, Snails / Q000187:drug effects*; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects*; D012621:Seasons
D009270:Naloxone; D009020:Morphine; D004298:Dopamine
Sezonnye osobennosti vozdeĭstviia morfina i naloksona na dofaminovyĭ otvet neĭronov Helix.