Enhancement by levamisole of the contractions induced by prostaglandin E2 in the guinea-pig isolated ileum.
The effect of levamisole on prostaglandin E2 (PGE2)-evoked contractions was studied on guinea-pig isolated ileum. Addition of levamisole (10 micrograms/ml) to the organ bath produced a pronounced increase in the amplitude of the PGE2-evoked responses. Levamisole (10 micrograms/ml) also sensitized the guinea-pig isolated ileum to 5-hydroxytryptamine and bradykinin, but not to histamine. The effect of the levamisole was not due to stimulation of autonomic ganglia or cholinergic activity since it was unaffected by hexamethonium or atropine, but it was prevented by indomethacin.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001920:Bradykinin / Q000494:pharmacology; D004357:Drug Synergism; D006168:Guinea Pigs; D006584:Hexamethonium Compounds / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D007082:Ileum / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology; D007978:Levamisole / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D011458:Prostaglandins E / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology
D006584:Hexamethonium Compounds; D011458:Prostaglandins E; D007978:Levamisole; D012701:Serotonin; D001285:Atropine; D006632:Histamine; D001920:Bradykinin; D007213:Indomethacin