Regional cerebral blood flow in the newborn beagle pup: the germinal matrix is a "low-flow" structure.
The newborn beagle pup serves as a model for neonatal intraventricular hemorrhage (IVH). Fluctuations in germinal matrix blood flow are left to play a major role in the pathogenesis of IVH. We studied regional cerebral blood flow in awake newborn beagle pups utilizing [14C]-iodoantipyrine as a blood flow indicator and quantitative autoradiography. The equilibrium [tissue]:[blood] partition coefficient for iodoantipyrine was 1.13 +/- .06 for grey matter. Blood flow was calculated for cerebral cortex (frontal = 59 +/- 9 ml/100 g/min), 14 subcortical nuclear structures (e.g., caudate = 45 +/- 6 ml/100 g/min), 3 white matter structure (centrum semiovale = 7 +/- 1 ml/100 g/min), and germinal matrix (7 +/- 1 ml/100 g/min) (mean +/- S.E.). We conclude that under normal physiologic conditions the germinal matrix receives relatively low blood flow. This information can be used for comparison with germinal matrix blood flow during adverse experimental conditions.
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D000983:Antipyrine / Q000031:analogs & derivatives; D001345:Autoradiography; D002250:Carbon Radioisotopes; D002421:Caudate Nucleus / Q000098:blood supply; D002540:Cerebral Cortex / Q000098:blood supply; D002560:Cerebrovascular Circulation; D004285:Dogs
D002250:Carbon Radioisotopes; D000983:Antipyrine; C008135:iodoantipyrine