[Specific activity of an UV-inactivated antirabies vaccine made from brain tissue administered in a shortened schedule].
The results obtained in the study of the specific potency of rabies vaccine prepared from sheep brain tissue and inactivated by UV irradiation indicate that, even in the presence of the lowest immunogenicity index (0.5), 5-6 injections of the vaccine, made not daily, but at interval of 3 and 7 days, induced the production of antibodies in the titers not lower than those resulting from 14-20 daily injections of the same vaccine or Fermi vaccine. The preparation inactivated by UV irradiation should be introduced for therapy according to the shortened immunization schedule with intervals, taking into account the immunogenicity index.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001921:Brain / Q000276:immunology*; D006801:Humans; D007115:Immunization Schedule; D008875:Middle Aged; D011817:Rabbits; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000276:immunology* / Q000528:radiation effects; D011820:Rabies virus / Q000276:immunology; D012756:Sheep / Q000276:immunology; D013997:Time Factors; D014466:Ultraviolet Rays; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology / Q000528:radiation effects
D000914:Antibodies, Viral; D011819:Rabies Vaccines; D014613:Vaccines, Attenuated
Spetsificheskaia aktivnost' inaktivirovannoi UF-luchami antirabicheskoĭ vaktsiny iz tkani mozga pri sokrashchennoĭ skheme vvedeniia.