[Mechanism of action of 2-(1'-aminoethyl)-bicyclo[2.2.1]heptane hydrochloride].
The effect of 2-[1'-aminoethyl)-bicyclo[2.2.1]heptane chlorohydrate on the accumulation of hemagglutinating activity of chick embryo fibroblasts infected with influenza A/FPV/Rostock/34 (Hav1N1) and A/WSN/33 (H0N1) was studied. The drug inhibited hemagglutinines accumulation when added at various intervals after infection, the maximum effect having been observed upon its addition to the maintenance medium immediately after adsorption. Polyacrylamide gel electrophoresis showed the drug to reduce the synthesis of virus-specific proteins of A/FPV and to inhibit considerably the transcriptase activity of A/FPV and A/WSN viruses in vitro.
D000327:Adsorption; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006387:Hemagglutination, Viral / Q000187:drug effects; D009980:Influenza A virus / Q000187:drug effects; D009636:Norbornanes / Q000627:therapeutic use*; D009976:Orthomyxoviridae Infections / Q000188:drug therapy; D013997:Time Factors; D014776:Virus Cultivation
D000998:Antiviral Agents; D009636:Norbornanes; C034486:2-(1'-aminoethyl)bicyclo(2.2.1)heptane
O mekhanizme deĭstviia 2-(1'-aminoétil)-bitsiklo[2.2.1]geptan khlorgidrata.