Metabolism of [14C]-C21 steroids in the human fetal ovaries.
The incubation of [14C]-pregnenolone with the mince of human fetal ovary produced progesterone. 17-hydroxypregnenolone, 5-pregnene-3 beta, 20 alpha-diol. 5-pregnene-3 beta, 17 alpha, 20 alpha-triol and 5 alpha-pregnan-3,20-dione. The other 7 tissues, uterus, liver, intestine, skin, kidney, lung and pancreas, obtained from the same fetus were also able to produce some of these metabolites. When [14C]-pregnenolone, progesterone or 17-hydroxyprogesterone was incubated with 800 g supernatant of fetal ovaries, progesterone, 17-hydroxypregnenolone and 5-pregnene-3 beta, 20 alpha-diol were formed from pregnenolone, 17-hydroxyprogesterone and 20 alpha-hydroxy-4-pregnen-3-one were formed from progesterone and 17 alpha, 20 alpha-dihydroxy-4-pregnen-3-one was formed from 17-hydroxyprogesterone. These results indicate that the fetal ovary has the activities of 5-ene-3 beta-hydroxysteroid dehydrogenase, 17-hydroxylase, 20 alpha-hydroxysteroid dehydrogenase and 5 alpha-reductase.
D006907:17-alpha-Hydroxypregnenolone / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism; D006801:Humans; D006908:Hydroxyprogesterones / Q000378:metabolism; D007700:Kinetics; D010053:Ovary / Q000196:embryology* / Q000378:metabolism; D011277:Pregnanediones / Q000378:metabolism; D011283:Pregnenes / Q000378:metabolism; D011284:Pregnenolone / Q000031:analogs & derivatives / Q000378:metabolism; D011374:Progesterone / Q000378:metabolism; D011372:Progestins / Q000378:metabolism*; D014018:Tissue Distribution
D006908:Hydroxyprogesterones; D011277:Pregnanediones; D011283:Pregnenes; D011372:Progestins; D006907:17-alpha-Hydroxypregnenolone; D011374:Progesterone; D011284:Pregnenolone; C009033:5-pregnene-3,20-diol; C026087:5-pregnene-3 beta,17 alpha,20 alpha-triol