Effects of several antimalarials and phenothiazine compounds on the formation of coat structure from clathrin.
We have evaluated the effects of two phenothiazine and several antimalarial drugs on the rates of polymerization of 8S clathrin molecules to 300S coat structures. Most of the drugs investigated have been shown in other studies to inhibit receptor-mediated endocytosis through the coated pit regions of plasma membranes. The two types of drugs were found to accelerate the polymerization rate without having much effect on the size distribution of the polymer species. The activities of the drugs appear to depend on the dibasic moiety and a large, hydrophobic aromatic ring in their structures.
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002417:Cattle; D002966:Clathrin; D004705:Endocytosis / Q000187:drug effects; D008565:Membrane Proteins / Q000378:metabolism*; D010640:Phenothiazines / Q000494:pharmacology*; D011108:Polymers / Q000378:metabolism; D013329:Structure-Activity Relationship
D000962:Antimalarials; D002966:Clathrin; D008565:Membrane Proteins; D010640:Phenothiazines; D011108:Polymers