Fatty acid modification of Newcastle disease virus glycoproteins.
The fatty acid acylation of Newcastle disease virus hemagglutininin-neuraminidase and fusion glycoproteins was assayed. [3H]palmitate label was associated with cytoplasmic fusion proteins (F0 and F1) and virion-associated F1. In contrast, there was no detectable [3H]palmitate label associated with the hemagglutin-neuraminidase protein in Newcastle disease virus-infected Chinese hamster ovary cells or chicken embryo cells or in virions released from these cells. Thus, fatty acid modification may not be important for the maturation of some glycoproteins.
D000215:Acylation; D000818:Animals; D002460:Cell Line; D002642:Chick Embryo; D006224:Cricetinae; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D006389:Hemagglutinins, Viral; D009439:Neuraminidase; D009522:Newcastle disease virus / Q000378:metabolism*; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000378:metabolism*; D014764:Viral Proteins / Q000378:metabolism*
D006023:Glycoproteins; D006389:Hemagglutinins, Viral; D010169:Palmitic Acids; D014764:Viral Proteins; D019308:Palmitic Acid; D009439:Neuraminidase