3, 5-Dibromo-2'-chloro-4'-isothiocyanatosalicylanilide, a potent anthelmintic.
The compound, 3, 5-dibromo-2'-chloro-4'-isothiocyanatosalicylanilide, has been tested against various nematode and cestode parasites in experimental and domestic animals. It shoved 100% activity against Ancylostoma ceylanicum, A tubaeformis, Syphacia obvelata, ascaridia galli, Toxocara spp., Toxascaris sp., Gnathostoma spinigerum, Hymenolepis nana, Raillietina spp. and Taenia spp. in doses 25-70 mg/kg given in single or multiple administrations.
D000722:Ancylostoma / Q000187:drug effects / Q000469:parasitology; D000818:Animals; D002415:Cats; D002645:Chickens; D006224:Cricetinae; D004285:Dogs; D004341:Drug Evaluation; D005260:Female; D006373:Helminthiasis / Q000188:drug therapy*; D006376:Helminths / Q000187:drug effects / Q000469:parasitology*; D006725:Hookworm Infections / Q000188:drug therapy; D008297:Male; D051379:Mice; D009534:Niclosamide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009559:Nippostrongylus / Q000187:drug effects / Q000469:parasitology; D013045:Species Specificity
C029767:3,5-dibromo-2-chlorosalicylanilide-4'-isothiocyanate; D009534:Niclosamide