[Results of measuring the blood flow in the gastric mucosa of dogs by the 99mTc-4-methylaminophenazone clearance method].
In anesthetized dogs, a good correlation was found between the [99mTc]-4-methylaminophenazone and aminopyrine clearances measured in the same animal after administration of gastric secretory stimulants vasopressin or glucagon. A similarly good correlation was observed between the [99mTc]-4-methylaminophenazone and [14C]-aminopyrine clearance during histamine administration. The clearance values were always corrected by the actual degree of dissociation of the radioactive molecules. The results suggest that [99mTc]-4-methylaminophenazone is suitable for the study of the circulatory changes in human gastric mucosa. It has the advantages of a much lower absorbed dose of radiation for the patient and his surroundings, a simplified measurement technique and considerably reduced expenses.
D000632:Aminopyrine / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D002250:Carbon Radioisotopes; D004177:Dipyrone / Q000031:analogs & derivatives* / Q000378:metabolism; D004285:Dogs; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply* / Q000187:drug effects; D005934:Glucagon / Q000494:pharmacology; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008722:Methods; D015609:Organotechnetium Compounds; D010418:Pentagastrin / Q000494:pharmacology; D047069:Pyrazolones; D013667:Technetium / Q000378:metabolism; D014667:Vasopressins / Q000494:pharmacology
D002250:Carbon Radioisotopes; D015609:Organotechnetium Compounds; D047069:Pyrazolones; C034867:technetium Tc 99m-4-methylaminophenazone; D000632:Aminopyrine; D014667:Vasopressins; D004177:Dipyrone; D013667:Technetium; D005934:Glucagon; D010418:Pentagastrin
Rezul'taty izmereniia krovotoka v slizistoĭ obolochke zheludka u sobak metodom klirensa 99mTc-4-metilaminofenazona.