General inhibition of embryonic cell aggregation by neoplastic cells.
The presence of small numbers of cancer cells cause an inhibition in the aggregation of embryonic chick neural retina cells. Experiments were made to investigate the inhibitory action of malignant mouse and virus-transformed chick neural retina cells on the aggregation and adhesion of several embryonic cell types. Malignant mouse cells, and their conditioned medium, inhibited the aggregation and adhesion of embryonic skeletal muscle heart and liver cells. The transformed retinal cells inhibited the aggregation of neural retina cells. These results suggest that the effect of cancer cells on the behavior of embryonic cells is a general one not related to the origin of the cancer cells.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor; D002448:Cell Adhesion; D002449:Cell Aggregation; D002471:Cell Transformation, Neoplastic / Q000196:embryology*; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D002642:Chick Embryo; D008099:Liver; D009130:Muscle, Smooth; D009132:Muscles; D012160:Retina / Q000196:embryology*