[Alexander's disease (author's transl)].
A report on clinical course and morphological findings in a case of Alexander's disease is given in a boy aged 4 year and 6 months. The disease started in the second month with progressive retardation. At the age of 13 months, a ventriculo-peritoneal shunt was performed because of dilatation of ventricles. Death occurred due to cerebral dysfunction. Microscopic investigation showed a considerable demyelination and the presence of numerous Rosenthal fibers. The results are compared with observations in the literature of Alexander's disease during early infancy.
D001344:Autopsy; D001921:Brain / Q000473:pathology; D002557:Cerebrospinal Fluid Shunts; D002675:Child, Preschool; D006801:Humans; D006849:Hydrocephalus / Q000473:pathology*; D008607:Intellectual Disability / Q000473:pathology*; D008297:Male; D013116:Spinal Cord / Q000473:pathology; D013577:Syndrome
Alexandersche Krankheit.