[The binding of erythromycin to proteins in the serum of humans during various infections (author's transl)].
A large amount of the erythromycin in the serum is bound to acidic alpha 1-glycoprotein; the exact share is dependent on the concentration. The concentration of acidic alpha 1-glycoprotein can be elevated during infections. Thus, a larger amount of the erythromycin is bound, leaving less free antibiotic.
D001424:Bacterial Infections / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism*; D004917:Erythromycin / Q000097:blood*; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D009961:Orosomucoid / Q000378:metabolism; D011485:Protein Binding; D012016:Reference Values; D012709:Serum Albumin / Q000378:metabolism
D001798:Blood Proteins; D008074:Lipoproteins; D009961:Orosomucoid; D012709:Serum Albumin; D004917:Erythromycin
Die Bindung von Erythromycin an Serumproteine des Menschen bei verschiedenen Infektionen.