A novel metabolite of oxycodone in the urine of rabbits.
In addition to six metabolites of oxycodone which were reported previously, 7 beta-hydroxy-6 beta-oxycodol was further isolated as one of the major metabolites in rabbits. The structure of this novel metabolite was characterized by mass and nuclear magnetic resonance spectra. Such a metabolite possessing vicinal hydroxyl groups in aliphatic ring is very new in the metabolism of narcotic analgesics.
D000818:Animals; D001711:Biotransformation; D003061:Codeine / Q000031:analogs & derivatives*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010098:Oxycodone / Q000652:urine*; D011817:Rabbits
D010098:Oxycodone; D003061:Codeine