Measurement of gastric mucosal blood flow in dogs by the 99mTc-4-methylaminophenazone clearance technique.
In anesthetized dogs, correlation was found between the 99mTc-4-methylaminophenazone and aminopyrine clearance measured in the same animal after administration of the gastric secretory stimulants vasopressin or glucagon. Similar correlation was observed between the 99mTc-4-methylaminophenazone and [14C]aminopyrine clearance during histamine administration. The clearance values were always corrected by the actual degree of dissociation of the radioactive molecules. The results suggest that 99mTc-4-methylaminophenazone is suitable to study circulatory changes in human gastric mucosa. Advantages of this compound include a much lower dose of radiation absorbed by the patient and his surroundings, a simplified measurement technique, and considerably reduced expenses.
D000632:Aminopyrine / Q000031:analogs & derivatives* / Q000097:blood; D000818:Animals; D004177:Dipyrone / Q000031:analogs & derivatives*; D004285:Dogs; D005753:Gastric Mucosa / Q000098:blood supply*; D005934:Glucagon / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D015609:Organotechnetium Compounds; D047069:Pyrazolones; D012039:Regional Blood Flow; D013667:Technetium; D014667:Vasopressins / Q000494:pharmacology
D015609:Organotechnetium Compounds; D047069:Pyrazolones; C034867:technetium Tc 99m-4-methylaminophenazone; D000632:Aminopyrine; D014667:Vasopressins; D004177:Dipyrone; D013667:Technetium; D006632:Histamine; D005934:Glucagon