[Effect of arecoline and m- and n-cholinolytics on 22Na incorporation into the neurons of various sections of the rat brain].
Experiments on rats were made to study the effect of cholinolytics and cholinomimetics on 33Na neuronal incorporation in different regions of the brain. Amizyl and glipin increased 22Na incorporation into the neurones of the hypothalamus and striatum and lowered membrane permeability of brain cortex neurones. Diphacil (trasentine) and tropacin inhibited 22Na neuronal incorporation in the brain cortex and did not change membrane permeability of the nerve cells of other structures. Arecoline increased membrane permeability of the neurones of all the brain regions studied. It is suggested that the neurotropic substances have selective action on membrane permeability of neurones in different regions of the rat brain.
D000818:Animals; D001115:Arecoline / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D010276:Parasympatholytics / Q000494:pharmacology*; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D012979:Sodium Radioisotopes / Q000378:metabolism
D010276:Parasympatholytics; D012979:Sodium Radioisotopes; D001115:Arecoline; D012964:Sodium
Vliianie arekolina, M- i N-kholinolitikov na vkliuchenie 22Na v neĭrony raznykh otdelov mozga krys.