Interaction of serotonin with vagal- and ACh-induced bronchoconstriction in canine lungs.
The bronchoconstrictor response to electrical stimulation of the peripheral ends of both cut cervical vagus nerves was potentiated by serotonin aerosols in 10 experiments in 7 anesthetized dogs. The bronchoconstrictor response to acetylcholine (ACh) aerosols was unchanged after serotonin. We conclude that serotonin acts at the level of the parasympathetic ganglia or the postganglionic nerve terminal to potentiate the bronchoconstrictor response to vagal stimulation.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001982:Bronchial Diseases / Q000139:chemically induced*; D003251:Constriction, Pathologic / Q000139:chemically induced; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D011976:Receptors, Muscarinic / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology*; D014630:Vagus Nerve / Q000502:physiology*
D011976:Receptors, Muscarinic; D012701:Serotonin; D000109:Acetylcholine