[Possibility of preventing muscular dystrophy in E avitaminosis with alpha-tocopheronolactone and diludin].
The efficacy of pharmacopeial alpha-tocopheryl acetate, alpha-tocopheronolactone and the antioxidant diludin was studied as to the possibilities of preventing E-hypovitaminosis muscle dystrophy in rabbits. alpha-Tocopheronolactone action was similar to that of pharmacopeial alpha-tocopheryl acetate as regards E-vitamin activity that was manifested by an increase in the body mass, decrease in the urine creatine index and maintenance of normal ubiquinone content, as well as of succinate-ubiquinone-reductase, NADH-ubiquinone-reductase and NADH-cytochrome c-reductase activity of rabbit skeletal muscle and heart mitochondria. On the contrary , as a result of the antioxidant administration, no direct correlation was found between ubiquinone content and activity of ubiquinone-dependent enzymatic systems of mitochondria. The data obtained attest to high E-vitamin activity of alpha-tocopheronolactone. The action of the latter was disclosed to be different from that produced by the antioxidant.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D003997:Dicarbethoxydihydrocollidine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D008928:Mitochondria / Q000378:metabolism; D009137:Muscular Dystrophy, Animal / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D011725:Pyridines / Q000627:therapeutic use*; D011817:Rabbits; D024505:Tocopherols; D014451:Ubiquinone / Q000378:metabolism; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000627:therapeutic use; D014811:Vitamin E Deficiency / Q000150:complications* / Q000378:metabolism; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000975:Antioxidants; D011725:Pyridines; C015160:etidin; D014451:Ubiquinone; D014810:Vitamin E; C034599:tocopheronolactone; D003997:Dicarbethoxydihydrocollidine; D024502:alpha-Tocopherol; D024505:Tocopherols
Izuchenie vozmozhnosti preduprezhdeniia myshechnoĭ distrotii pri E-avitaminoze al'fa-tokoferonolaktonom i diludinom.