A histochemical study of GABA-transaminase in the efferents of the pallidum.
Kainic acid lesions of the globus pallidus reduce the histochemically detectable GABA-transaminase activity in the ipsilateral subthalamic nucleus. A similar decrease in enzyme activity occurs in the lateral habenula following lesions of the entopeduncular nucleus. Previous results on the localization of GABA-transaminase in efferents of the striatum indicated that such histochemistry may be a useful adjunct for the demonstration of GABA pathways. The present data are consistent with some previous literature indicating that these two pallidal efferents may contain GABA.
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism*; D000818:Animals; D004525:Efferent Pathways / Q000201:enzymology*; D007839:Functional Laterality; D005917:Globus Pallidus / Q000187:drug effects / Q000201:enzymology*; D006651:Histocytochemistry; D007608:Kainic Acid / Q000494:pharmacology; D051381:Rats; D000637:Transaminases / Q000378:metabolism*
D000637:Transaminases; D000612:4-Aminobutyrate Transaminase; D007608:Kainic Acid