Low dose trimethoprim prophylaxis in long term control of chronic recurrent urinary tract infection.
26 patients with chronic urinary tract infections (UTI) were treated with 1 tablet of 100 mg trimethoprim (TMP) once daily for up to 6 months as long term prophylaxis. The recurrence rate before prophylaxis was 26/100 months, compared to a significantly lower frequency (3.3 recurrences/100 months, p less than 0.001) during prophylaxis. The post-prophylactic rate returned to the pre-prophylaxis rate: 23 recurrences/100 months. All Escherichia coli strains causing post-prophylactic UTI were TMP sensitive. The number of rectal enterobacteria were markedly reduced during prophylaxis (p less than 0.05). A 10% recovery of TMP resistant enterobacteria from rectal swabs was noted early (less than or equal to 1 month) during prophylaxis, but no significant further accumulation occurred.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004755:Enterobacteriaceae / Q000302:isolation & purification; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012007:Rectum / Q000382:microbiology; D012008:Recurrence; D013210:Staphylococcus / Q000302:isolation & purification; D014295:Trimethoprim / Q000008:administration & dosage*; D014521:Urethra / Q000382:microbiology; D014552:Urinary Tract Infections / Q000517:prevention & control*
D014295:Trimethoprim