OPT: a package of computer programs for parameter optimisation in clinical pharmacokinetics.
1 OPT is a series of computer programs designed to assist dose optimisation for individual patients. It is based on Bayesian Statistical Theory and Maximum Likelihood Estimation. 2 OPT uses prior information on the distribution of population pharmacokinetic parameters and plasma drug concentration measurements to obtain the "most likely' set of parameters for the individual. 3 Complex dosage regimes and non-steady state conditions can be handled. 4 OPT is designed for use in a Clinical Pharmacokinetics Laboratory where informed interpretation of results is essential. 5 The drugs for which the system is currently available include theophylline, digoxin, lignocaine, disopyramide, gentamicin and phenytoin (steady state data only).
D000284:Administration, Oral; D001682:Biological Availability; D003201:Computers; D004206:Disopyramide / Q000378:metabolism; D005839:Gentamicins / Q000378:metabolism; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007700:Kinetics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D013806:Theophylline / Q000378:metabolism
D005839:Gentamicins; D004364:Pharmaceutical Preparations; D013806:Theophylline; D004206:Disopyramide