[Androgen formation in the testes of hypophysectomized rats exposed to the antiandrogen niftolid (flutamide)].
The influence of 4-nitro-3-trifluoromethylisobutyranilide (niftolide, flutamide) on the blood plasma testosterone content, the level of the total and specific activity of testicular steroid- delta5-3beta-ol-dehydrogenase was studied in the experiments on male rats in the early (5 days) and late (30 days) periods after hypophysectomy. The operation completely prevents gonadal response to antiandrogen administration. The data obtained indicate that niftolide does not exert direct effect on androgen production in the rat testes.
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000378:metabolism; D000726:Androgen Antagonists / Q000494:pharmacology*; D000728:Androgens / Q000096:biosynthesis*; D000813:Anilides / Q000494:pharmacology*; D000818:Animals; D005485:Flutamide / Q000494:pharmacology*; D007016:Hypophysectomy; D008297:Male; D010902:Pituitary Gland / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000187:drug effects* / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D013997:Time Factors
D000726:Androgen Antagonists; D000728:Androgens; D000813:Anilides; D013739:Testosterone; D005485:Flutamide; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase
Obrazovinie androgenov v semennikakh gipofizéktomirovannykh krys pri vozdeĭstvii antiandrogena niftolida (flutamida).