[Effect of a drug combination on venous capacity].
The activity of the fixed combination Phlebodril on the venous hemodynamic system was studied in 20 healthy volunteers. A different reaction was seen. One part of the volunteers showed a significantly reduced venous capacity whereas the other part presented an increase in venous storage ability. This effect especially was observed after application of trimethylhesperidinchalcone, which increases the capillary resistance.
D000328:Adult; D001205:Ascorbic Acid / Q000627:therapeutic use; D002199:Capillary Permeability / Q000187:drug effects; D002599:Chalcone / Q000031:analogs & derivatives / Q000494:pharmacology*; D004311:Double-Blind Method; D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D006569:Hesperidin / Q000031:analogs & derivatives / Q000494:pharmacology*; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D011427:Propiophenones / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects*; D014680:Veins / Q000187:drug effects*
D004338:Drug Combinations; D005419:Flavonoids; D010936:Plant Extracts; D011427:Propiophenones; C035564:phlebodril; D002599:Chalcone; D006569:Hesperidin; D001205:Ascorbic Acid
Zur Wirkung eines Kombinationspräparates auf die Venenkapazität.