1,1-Dichloroethylene inhibition of liver endoplasmic reticulum calcium pump function.
This study shows that 1,1-DCE promptly inhibits a calcium homeostatic function of liver ER. The correlation with GSH depletion and the effect of MFOS induction on calcium pump inhibition suggest that this is a direct effect of a 1,1-DCE metabolite on the calcium pump. As a result of calcium pump inhibition, calcium released from the ER may serve to trigger changes that result in a massive influx of extracellular calcium and, ultimately, cytotoxicity.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism; D004000:Dichloroethylenes / Q000494:pharmacology*; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism*; D006843:Hydrocarbons, Chlorinated / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D004000:Dichloroethylenes; D006843:Hydrocarbons, Chlorinated; C029297:vinylidene chloride; D002118:Calcium