A comparison of antrafenine and aspirin on platelet aggregation and frusemide-induced diuresis.
The effects of antrafenine were compared with aspirin and placebo on platelet aggregation and on the diuretic action of frusemide in normal volunteers. Aspirin significantly reduced platelet aggregation at 3 and 6 hr after administration, but antrafenine only at 3 hr. Only aspirin significantly reduced the increase in urine sodium and potassium produced by frusemide.
D000328:Adult; D000700:Analgesics / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects*; D005260:Female; D005665:Furosemide / Q000037:antagonists & inhibitors*; D006801:Humans; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D010919:Placebos; D010974:Platelet Aggregation / Q000187:drug effects*
D000700:Analgesics; D010879:Piperazines; D010919:Placebos; C017014:antrafenine; D005665:Furosemide; D001241:Aspirin