Synthesis of thromboplastin protein by a murine macrophage-like cell line.
The established murine macrophage cell line J-774.1 responds to endotoxin with synthesis of thromboplastin apoprotein. The response develops in the absence of added lymphocytes and there is no increased responsiveness in cocultures of J-774.1 cells and BALB/c lymphocytes. J-774.1 cells therefore do not depend on lymphocyte cooperation for their response to endotoxin.
D000818:Animals; D001059:Apoproteins / Q000096:biosynthesis*; D002460:Cell Line; D004731:Endotoxins / Q000494:pharmacology; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D051379:Mice; D013925:Thromboplastin / Q000096:biosynthesis*
D001059:Apoproteins; D004731:Endotoxins; D013925:Thromboplastin