Identification of a specific olfactory receptor for 2-isobutyl-3-methoxypyrazine.
2-Isobutyl-3-methoxypyrazine, a potent bell-pepper odorant, binds to cow olfactory mucosa homogenate. The receptor is saturable in the micromolar range and is competitively inhibited by other bell-pepper odourants, but not by other pyrazines of different odours. Other tissues do not bind 2-isobutyl-3-methoxypyrazine at a significant extent. We suggest that this receptor is involved in odour discrimination.
D000818:Animals; D001667:Binding, Competitive; D002417:Cattle; D005260:Female; D008024:Ligands; D009831:Olfactory Mucosa / Q000378:metabolism*; D011719:Pyrazines / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D011984:Sensory Receptor Cells / Q000378:metabolism*; D013045:Species Specificity
D008024:Ligands; D011719:Pyrazines; C034376:2-isobutyl-3-methoxypyrazine