The role of expansion, of prostaglandins and catecholamines in the development of acute renal failure.
A single injection either of isotonic or hypertonic saline solutions protected rats against acute renal failure (ARF) induced with glycerol. This protection was accompanied by increased urinary prostaglandin E (PGE) concentration. On the contrary, a single s.c. injection either of hypotonic saline or isotonic glucose solution, which did not increase urinary PGE concentration, or depletion of the endogenous catecholamines, using reserpine, did not protect the animals against acute renal failure.
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000503:physiopathology* / Q000517:prevention & control; D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D003404:Creatinine / Q000378:metabolism; D005990:Glycerol; D008297:Male; D009994:Osmolar Concentration; D011458:Prostaglandins E / Q000652:urine*; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology*; D012965:Sodium Chloride / Q000494:pharmacology; D014527:Uric Acid / Q000378:metabolism
D002395:Catecholamines; D011458:Prostaglandins E; D014527:Uric Acid; D012965:Sodium Chloride; D012110:Reserpine; D003404:Creatinine; D005990:Glycerol