[Inhibition of fructose-induced hyperuricacidemia by pretreatment with phosphates].
To test the hypothesis that intravenous injections of fructose rapidly decreases liver ATP and Pi and results in the rapid degradation of adenine nucleotides and hyperuricemia, fructose was administered intravenously to a group of normal and gouty subjects; 4 gouty patients were treated with a phosphate solution prior fructose loading. The results obtained show that fructose administration plus phosphate solution prevents Pi depletion and inhibits fructose-induced hyperuricemia.
D000138:Acidosis / Q000139:chemically induced / Q000517:prevention & control*; D000227:Adenine Nucleotides / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D005632:Fructose; D006801:Humans; D008099:Liver / Q000378:metabolism; D010710:Phosphates / Q000627:therapeutic use*; D014527:Uric Acid / Q000097:blood*
D000227:Adenine Nucleotides; D010710:Phosphates; D014527:Uric Acid; D005632:Fructose; D000255:Adenosine Triphosphate
Inibizione dell'iperuricemia da fruttoso mediante pretrattamento con fosfati.