Neurologic and cardiac toxicity following iv application of methotrexate.
The case of a 61-year-old female patient with metastatic breast cancer is reported. She developed neurologic symptoms and supraventricular extrasystoles when she received iv methotrexate. These symptoms were reproducible and were not found with other drugs. The cause for this event is not clear.
D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary*; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D007275:Injections, Intravenous; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009422:Nervous System Diseases / Q000139:chemically induced*
D008727:Methotrexate