Delayed skin hypersensitivity reactions to human brain S-100 protein in psychiatric patients.
To confirm and extend previous observations concerning the correlation between cell-mediated immunity and psychiatric diseases, 511 patients with schizophrenia, cerebral atrophy, dementia, and mental retardation, and 32 control subjects and 27 control patients were skin-tested with human brain S-100 protein and human liver protein: 70.2-93.1% of tested psychiatric patients developed positive skin hypersensitivity reactions to S-100 protein, while 2.8-20.7% of patients reacted to liver protein. Of control subjects, 6.2-7.4% responded to S-100 protein, and 7.4-9.4% to liver protein. The findings indicate that cell-mediated immune processes may be involved in brain mechanisms underlying cerebral atrophy, depression, dementia, schizophrenia, and mental retardation.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001284:Atrophy; D001921:Brain / Q000276:immunology*; D002540:Cerebral Cortex / Q000473:pathology; D002648:Child; D003704:Dementia / Q000276:immunology; D003866:Depressive Disorder / Q000276:immunology; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D008607:Intellectual Disability / Q000276:immunology; D007428:Intradermal Tests; D008297:Male; D001523:Mental Disorders / Q000276:immunology*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology*; D009418:S100 Proteins / Q000276:immunology*; D012559:Schizophrenia / Q000276:immunology; D012867:Skin / Q000276:immunology
D009419:Nerve Tissue Proteins; D009418:S100 Proteins