In vitro vinblastine-induced tubulin paracrystals.
Purified calf brain tubulin has been induced to self-aggregate in vitro into paracrystalline structures by the anti-cancer drug vinblastine. The size, shape, optical birefringence, and drug stoichiometry of these tubulin-vinblastine paracrystals are similar to those of paracrystals formed in vivo. Similar structures can be formed with vincristine and desacetylvinblastine, but not with colchicine or podophyllotoxin.
D000818:Animals; D001923:Brain Chemistry; D002417:Cattle; D003078:Colchicine; D003460:Crystallization; D007700:Kinetics; D011034:Podophyllotoxin; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000302:isolation & purification; D014747:Vinblastine / Q000031:analogs & derivatives
D014404:Tubulin; D014747:Vinblastine; D011034:Podophyllotoxin; D003078:Colchicine