Interaction between thymosin, testosterone and estradiol on natural killer cell activity in mice.
Thymosin fraction 5, an immunopotentiating thymic preparation, significantly increases the cytotoxic capacity of NK cells isolated from the spleen. This stimulation is inhibited by testosterone and estradiol.
D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004336:Drug Antagonism; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D008297:Male; D008545:Melanoma / Q000276:immunology; D051379:Mice; D009374:Neoplasms, Experimental / Q000276:immunology; D013739:Testosterone / Q000494:pharmacology*; D013947:Thymosin / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*
D013951:Thymus Hormones; D013739:Testosterone; D004958:Estradiol; D013947:Thymosin