The synthesis and secretion of human placental lactogen (hPL) in cultured term placenta.
We studied the in vitro synthesis and secretion of hPL by human term placental tissue incubated in organ culture. Placental tissue maintains a constant pool of hPL. The synthesis of hPL may be the driving force for its secretion. The de novo synthesis and secretion rates of hPL were also investigated. The higher specific radioactivities of the secreted hPL than those found in the tissue may suggest that newly synthesized hPL is preferentially released. The intracellular distribution of hPL was also compared.
D005260:Female; D006801:Humans; D009924:Organ Culture Techniques; D010920:Placenta / Q000032:analysis / Q000378:metabolism*; D010928:Placental Lactogen / Q000378:metabolism*; D011247:Pregnancy
D010928:Placental Lactogen