[Effect of inhibition of prostaglandin biosynthesis on the spike activity and chemical sensitivity of cortical neurons in the rabbit].
Inhibition of prostaglandins synthesis by non-narcotic analgetics--aspirin, butadion and indometacin--produces an over effect of the background firing activity of the cortical units and on their sensitivity to microiontophoretic application of acetylcholine and norepinephrine in acute experiments on unanesthetized and unrestrained rabbits. As a rule, non-narcotic analgetics depressed background firing and reinforced responses to the neuro-mediators. Some neurons showed complete, but reversible inhibition of discharge activity and chemical sensitivity. Participation of prostaglandins in activity of the nerve cells is discussed.
D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D004347:Drug Interactions; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010653:Phenylbutazone / Q000494:pharmacology; D011453:Prostaglandins / Q000502:physiology*; D011817:Rabbits
D011453:Prostaglandins; D010653:Phenylbutazone; D000109:Acetylcholine; D001241:Aspirin; D009638:Norepinephrine; D007213:Indomethacin
Impul'snaia aktivnost' i khimicheskaia chuvstvitel'nost' neĭronov kory mozga krolikov v usloviiakh ugneteniia biosinteza prostaglandinov.