[Action of oestrogens on in vitro metabolism of trophoblast from human early pregnancy (author's transl)].
Warburg's manometric method was used to check the action of oestrone, oestradiol, and oestriol on aerobic and anaerobic glycolysis of placental respiration. Oestrogen concentrations of 10(-4) M were found to reduce oxygen consumption and to increase aerobic glycolysis. Such reduction of oxygen consumption was most strongly pronounced in connection with oestradiol, while the strongest rise in aerobic glycolysis took place in the wake of oestradiol and oestrone. Oestrogen action upon anaerobic glycolysis was variable, with the latter remaining unchanged by oestradiol, reduced in response to oestriol, and slightly increased by oestrone.
D000332:Aerobiosis; D000693:Anaerobiosis; D004958:Estradiol / Q000494:pharmacology; D004964:Estriol / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D004970:Estrone / Q000494:pharmacology; D005260:Female; D006019:Glycolysis / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D010101:Oxygen Consumption / Q000187:drug effects; D011247:Pregnancy; D014327:Trophoblasts / Q000187:drug effects* / Q000378:metabolism
D004967:Estrogens; D004970:Estrone; D004958:Estradiol; D004964:Estriol
Uber die Wirkungsweise von Ostrogenen auf den In-vitro-Stoffwechsel des aus menschlicher Frühschwangerschaft stammended Trophoblasten.