Amphetamine, haloperidol, and experience interact to affect rate of recovery after motor cortex injury.
Rats subjected to unilateral ablation of the motor cortex and placed on a narrow beam displayed transient contralateral paresis. An immediate and enduring acceleration of recovery was produced by a single dose of d-amphetamine given 24 hours after injury. This effect was blocked by haloperidol or by restraining the animals for 8 hours beginning immediately after amphetamine administration. A single dose of haloperidol given 24 hours after injury markedly slowed recovery. This effect was also blocked by restraining the animals.
D000818:Animals; D002395:Catecholamines / Q000502:physiology; D003913:Dextroamphetamine / Q000494:pharmacology* / Q000627:therapeutic use; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009044:Motor Cortex / Q000502:physiology*; D010243:Paralysis / Q000209:etiology / Q000628:therapy; D011214:Practice, Psychological; D051381:Rats; D012149:Restraint, Physical; D014945:Wound Healing / Q000187:drug effects
D002395:Catecholamines; D006220:Haloperidol; D003913:Dextroamphetamine