Hepatic microsomal metabolism of 1,3-butadiene.
1. In rat liver microsomes, 1,3-butadiene was metabolized to butadiene monoxide, which was subsequently transformed into 3-butene-1,2-diol by microsomal epoxide hydrolase. 2. In the metabolism of butadiene oxide in microsomes, four metabolites were detected, namely two stereoisomers of DL-diepoxybutane, and two stereoisomers of 3,4-epoxy-1,2-butanediol. No meso-diepoxybutane was detected.
D000818:Animals; D001711:Biotransformation; D002070:Butadienes / Q000378:metabolism*; D004852:Epoxy Compounds / Q000378:metabolism; D006018:Glycols / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D002070:Butadienes; D004852:Epoxy Compounds; D006018:Glycols; C024370:3,4-epoxy-1-butene; D006899:Mixed Function Oxygenases; C031763:1,3-butadiene; C034598:3-butene-1,2-diol; D010634:Phenobarbital