Initiation and inhibition of shivering in the rat: interaction between peripheral and central factors.
1. Unanaesthetized, female white laboratory rats were subjected to almost square-wave changes in ambient temperature, from 20 degrees C to 35 degrees C, in a small climatic chamber. 2. Intracerebroventricular injections of serotonin and methysergide were made in shivering, unanaesthetized rats. 3. The integrated electromyogram of m. suprascapularis was recorded as a quantitative measure of shivering activity to monitor the effects of the above procedures. 4. Both warm transients and serotonin inhibited shivering, but methysergide blocked only the effect of serotonin.
D000818:Animals; D002490:Central Nervous System / Q000502:physiology*; D004576:Electromyography; D005260:Female; D007276:Injections, Intraventricular; D008784:Methysergide / Q000494:pharmacology; D010525:Peripheral Nerves / Q000502:physiology*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D012768:Shivering / Q000187:drug effects*; D013997:Time Factors
D012701:Serotonin; D008784:Methysergide