[Crescents in focal (mesangiopathic) glomerulonephritis].
The main pathological alterations in focal glomerulonephritis are found in mesangium. The capillary walls are almost intact or slightly affected. In spite of that the epithelial crescents in that diseases are very frequent. There is no explanation available about that fact in literature. With the electron microscopic examination of punch biopsic material of a girl, aged 17, with focal glomerulonephritis a phenomenon not described so far, was observed. Laceration of the trunk and not capillary basal membrane was observed in the mesangial trank with numerous electron dense depositions and formation of a crescent, merging directly into the mesangial matrix. That finding, single and wanting a confirmation, is considered to be worth reporting. It could give an explanation of the fact why so many delineated crescents are so often found in focal glomerulonephritis, though the alterations in the peripheral capillary walls are relatively scarce and light.
D000293:Adolescent; D001485:Basement Membrane / Q000648:ultrastructure; D001706:Biopsy; D002196:Capillaries / Q000648:ultrastructure; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology*; D005923:Glomerulosclerosis, Focal Segmental / Q000473:pathology*; D006801:Humans; D007678:Kidney Glomerulus / Q000098:blood supply / Q000648:ultrastructure*; D008854:Microscopy, Electron
Poluluniiata pri ognishten (mezangiopatichen) glomerulonefrit.