Direct chromosomal analysis of human spermatozoa: preliminary results from 18 normal men.
Chromosomal analysis of 240 spermatozoa from 18 normal men was performed using in vitro fertilization of zona-free golden hamster eggs. The frequency of chromosome abnormalities in this population was 9.2% (22/240). Of the abnormal complements, 18 were aneuploid (13 hyperploid and five hypoploid) and four had a chromosome break. The sex ratio of Y-bearing to X-bearing sperm was .68. The frequency and type of sperm chromosome abnormalities is compared with those seen in spontaneous abortions.
D000022:Abortion, Spontaneous / Q000235:genetics; D000328:Adult; D000782:Aneuploidy; D000818:Animals; D002869:Chromosome Aberrations; D006224:Cricetinae; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007621:Karyotyping; D008297:Male; D011247:Pregnancy; D012730:Sex Chromosomes; D012744:Sex Ratio; D013094:Spermatozoa / Q000648:ultrastructure*