To the pharmacological profile of maprotiline.
Experimental EEG study of sleep-vigil cycles in rats with implanted brain electrodes showed that maprotiline has lower inhibitory effects on the REM sleep, sleep onset and mean duration of sleep cycles than imipramine. Maprotiline reveals significantly lower cardiotoxicity than imipramine and amitriptyline in the test on chick embryo heart. Embryotoxicity risk, evaluated on chick embryo by the method CHEST is significantly lower in maprotiline than in imipramine, nortriptyline and amitriptyline.
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000328:Adult; D000818:Animals; D000873:Anthracenes / Q000494:pharmacology*; D001143:Arousal / Q000187:drug effects; D002642:Chick Embryo; D003866:Depressive Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006323:Heart Arrest / Q000139:chemically induced; D006801:Humans; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D008376:Maprotiline / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism; D012894:Sleep Stages / Q000187:drug effects
D000873:Anthracenes; D011985:Receptors, Serotonin; D008376:Maprotiline; D012701:Serotonin; D007099:Imipramine