Rearrangement in rDNA-bearing chromosomes in cell lines from neoplastic cells.
Cytological hybridization in situ and karyotypic analysis have been used to investigate positional changes in rDNA, and morphological changes in rDNA-bearing chromosomes, in a series of cell lines established from patients with various proliferative disorders. Characteristic features of chromosomes in these cell lines include extreme differences in the number of rRNA genes per locus, translocations involving rDNA, and distinct rearrangements of a large portion of the rDNA complex to a q-terminal position on acrocentric chromosomes.
D002460:Cell Line; D002869:Chromosome Aberrations; D004247:DNA / Q000032:analysis / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D007621:Karyotyping; D009369:Neoplasms / Q000235:genetics*; D012270:Ribosomes / Q000648:ultrastructure; D014178:Translocation, Genetic
D004247:DNA