Comparison of the steroid-induced, intestinal, and hepatic isoenzymes of alkaline phosphatase in the dog.
The steroid-induced, intestinal, and hepatic isoenzymes of canine alkaline phosphatase (ALP) were compared, using antibodies against the steroid-induced ALP isoenzyme, heat inactivation, phenylalanine inhibition, prednisolone inhibition, and Michaelis constant determinations. The results indicate that the steroid-induced and intestinal ALP isoenzymes are similar and indicate that the steroid-induced isoenzyme might be a product of the same gene that controls the intestinal isoenzyme.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors / Q000235:genetics*; D000818:Animals; D003480:Cushing Syndrome / Q000201:enzymology / Q000662:veterinary*; D004283:Dog Diseases / Q000201:enzymology*; D004285:Dogs; D004591:Electrophoresis, Polyacrylamide Gel; D005796:Genes / Q000187:drug effects; D006358:Hot Temperature; D007421:Intestine, Small / Q000201:enzymology*; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000235:genetics*; D008099:Liver / Q000201:enzymology*; D008297:Male; D009092:Mucous Membrane / Q000201:enzymology; D009439:Neuraminidase / Q000494:pharmacology; D010649:Phenylalanine / Q000494:pharmacology; D011239:Prednisolone / Q000494:pharmacology; D011817:Rabbits / Q000276:immunology
D000305:Adrenal Cortex Hormones; D007527:Isoenzymes; D010649:Phenylalanine; D011239:Prednisolone; D000469:Alkaline Phosphatase; D009439:Neuraminidase