[Activity of oxidative enzymes of the Krebs cycle in the brain of animals adapted to supercooling].
Multiple (15-17) coolings up to the rectal body temperature (19-20 degrees C) without application of narcotic substances bring about various changes in the activity of the rat brain tricarboxylic acid cycle dehydrogenases: the activity of malate, succinate and alpha-ketoglutarate dehydrogenases increases significantly, that of isocitrate dehydrogenase decreases, that of pyruvate dehydrogenase--remains unchanged. The reaction to cooling in animals adapted to supercooling is also specific: in rats cooled for the first time in the state of "cold narcosis" succinic acid is mainly consumed in the brain, and in the adapted rats cooled down to 19-20 degrees C alpha-ketoglutarate dehydrogenase plays an important role.
D000064:Acclimatization; D000818:Animals; D001831:Body Temperature; D001921:Brain / Q000502:physiology*; D002952:Citric Acid Cycle; D003080:Cold Temperature; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D007655:Ketoglutarate Dehydrogenase Complex / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism
D011768:Pyruvate Dehydrogenase Complex; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D007655:Ketoglutarate Dehydrogenase Complex; D013385:Succinate Dehydrogenase
Aktivnost' okislitel'nykh fermentov tsikla Krebsa v golovnom mozge adaptirovannykh k pereokhlazhdeniiu zhivotnykh.