Dissociation between renal gluconeogenesis and ammoniagenesis after acute liver intoxication.
Renal glucose and ammonia production as well as phosphoenolpyruvate carboxykinase and phosphate-dependent glutaminase activities were measured for acute liver intoxication. Gluconeogenesis and phosphoenolpyruvate carboxykinase activity increased, whereas ammonia production and phosphate-dependent glutaminase showed no changes with respect to the controls. The dissociation between gluconeogenesis and ammoniagenesis may be explained by the differential effect on the enzymes in these conditions.
D000138:Acidosis / Q000378:metabolism; D000641:Ammonia / Q000378:metabolism*; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D005260:Female; D005688:Galactosamine / Q000378:metabolism; D005943:Gluconeogenesis / Q000187:drug effects*; D007668:Kidney / Q000378:metabolism*; D007672:Kidney Cortex / Q000378:metabolism; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D005688:Galactosamine; D000641:Ammonia; D010729:Phosphoenolpyruvate Carboxykinase (GTP)