Luteal phase defect as a marker of imminent ovarian failure.
A case of premature ovarian failure in a patient serendipitously studied with regard to clinical and histologic parameters during the 2 years preceding her diagnosis is presented. Progressively decreasing ovarian function was observed, beginning with a luteal phase defect and culminating in afollicular ovarian failure. Concepts concerning the etiologies and pathophysiology of premature ovarian failure are reviewed, and similarities to the natural climacteric are discussed.
D000328:Adult; D005260:Female; D006801:Humans; D008183:Luteal Phase; D008598:Menstruation; D010049:Ovarian Diseases / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D010050:Ovarian Function Tests; D013997:Time Factors