Evaluation of intramuscular ceruletide for shortening small bowel transit time.
A double-blind crossover study in 31 normal volunteers showed that intramuscular injection of ceruletide (0.3 microgram/kg) significantly accelerated small bowel transit of barium when compared to placebo. The only adverse effect was frequent pain at the injection site. There was a significant degradation in the quality of small bowel coating and distension in only 10% of the volunteers. Despite these problems, intramuscular administration of ceruletide may become a useful method for decreasing the prolonged time required for most small bowel examinations.
D000328:Adult; D001466:Barium Sulfate; D002108:Ceruletide / Q000008:administration & dosage; D004311:Double-Blind Method; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007273:Injections, Intramuscular; D007421:Intestine, Small / Q000000981:diagnostic imaging*; D008297:Male; D011859:Radiography; D011897:Random Allocation; D013997:Time Factors
D001466:Barium Sulfate; D002108:Ceruletide