Experimental and clinical pharmacokinetics of nitrofurantoin in the early period of life.
The investigation of pharmacokinetics showed age-dependent rate of nitrofurantoin elimination in rats. Nitrofurantoin half-life of 0.41 hr in adults was prolonged to 0.95 hr in 2-weeks-old rats. Nitrofurantoin excretion rate was decreased in children younger than 2 years. Older children excreted in urine 44.32 +/- 16.07 and younger 25.07 +/- 5.7 per cent of the given dose of nitrofurantoin, indicating the lower capacity for nitrofurantoin elimination via kidneys.
D000375:Aging; D000818:Animals; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007700:Kinetics; D008657:Metabolic Clearance Rate; D009582:Nitrofurantoin / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D014552:Urinary Tract Infections / Q000097:blood / Q000188:drug therapy*
D009582:Nitrofurantoin