Effect of age on sensitivity of human lymphocytes to radiation. A brief note.
Survival of human lymphocytes after X-ray and ultraviolet irradiation was studied in individuals of various ages using a technique of cloning in soft agar. There was no effect of age on survival after ultraviolet irradiation but lymphocytes from elderly individuals were approximately twice as sensitive to X-radiation as lymphocytes from young individuals. The results are relevant to the possible importance of DNA damage and repair in cellular ageing.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D002470:Cell Survival / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008875:Middle Aged; D014466:Ultraviolet Rays