Metabolism of digoxin and absorption site.
After oral intake of enteric-coated granules containing [3H]-digoxin extensive metabolism was observed. Maximum 66% of the 24 h urinary excretion was identified as [3H]-dihydrodigoxin, using high performance liquid chromatography for the analysis. It is suggested that metabolism of digoxin may depend on the absorption site.
D001711:Biotransformation; D002214:Capsules; D004077:Digoxin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D012996:Solutions; D013608:Tablets, Enteric-Coated
D002214:Capsules; D012996:Solutions; D013608:Tablets, Enteric-Coated; C000967:dihydrodigoxin; D004077:Digoxin