Teratogenic evaluation of ethylene chlorhydrin (ECh, 2-chlorethanol) in mice.
ECh administered intragastrically to pregnant CD-1 mice from the 6th to the 16th day of gestation at a dose of 100 mg/kg produced a significant reduction in maternal weight gain and a decrease in fetal body weight and liver weight. A lower dose of 50 mg/kg had no consistent effect and a higher dose of 150 mg/kg was maternally lethal. Administration of ECh in the drinking water at doses of 16, 43, 77, or 227 mg/kg did not produce any adverse effects on maternal or fetal body weight, viability, or fetal anatomical development.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002728:Chlorohydrins / Q000009:adverse effects*; D000431:Ethanol / Q000009:adverse effects; D005023:Ethylene Chlorohydrin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005313:Fetal Death; D005333:Fetus / Q000187:drug effects; D051379:Mice; D011247:Pregnancy
D002728:Chlorohydrins; D000431:Ethanol; D005023:Ethylene Chlorohydrin