Increased hyperthermal response of previously irradiated mouse intestine.
The effect of prior irradiation (6-10 Gy of X rays) on the response of mouse jejunum to 43.0 degrees C hyperthermia was investigated. A dose of 6 Gy has no significant effect on the crypt loss measured after hyperthermia. However, intestine which had received 8-10 Gy showed increased susceptibility to subsequent thermal injury. Between approximately one and 2 weeks after 9 Gy, the thermal response of the intestine of CFLP mice increased such that, at maximal effect, heating pre-irradiated intestine at 43.0 degrees C was approximately equivalent to heating untreated intestine at 43.5 degrees C. The effect of prior irradiation was transient and appeared to have been "forgotten" after 2-3 months, a finding of particular relevance to the clinical situation. The results are discussed with reference to any radiation injury to intestine which might influence the expression of hyperthermal damage in situ.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006358:Hot Temperature; D007583:Jejunum / Q000473:pathology / Q000528:radiation effects*; D051379:Mice; D008815:Mice, Inbred Strains; D011833:Radiation Injuries, Experimental / Q000473:pathology; D013997:Time Factors