2-(Aminomethyl)phenols, a new class of saluretic agents. 4. Effects of oxygen and/or nitrogen substitution.
A series of oxygen and/or nitrogen substituted 2-(aminomethyl)phenols was synthesized and tested orally in rats for saluretic and diuretic effects. Intravenous dog data are included as supplementary material to demonstrate diuretic responses, or lack thereof, in a second species. In general, substitution on nitrogen with groups other than lower alkyl or substitution on nitrogen and/or oxygen with groups resistant to hydrolysis substantially diminished or ablated saluretic effects.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D006868:Hydrolysis; D007275:Injections, Intravenous; D009318:Natriuresis / Q000187:drug effects*; D009584:Nitrogen; D010100:Oxygen; D010636:Phenols / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D010636:Phenols; D009584:Nitrogen; D010100:Oxygen