An original hypercalcemic infantile renal tum or without bone metastasis: heterotransplantation to nude mice: report of two cases.
Two cases of hypercalcemic infantile renal tumor without macroscopic bone metastases are reported. Optical and ultrastructural characteristics as well as biological and clinical data are sufficiently different from those of other infantile renal tumors to justify the individualization of an original tumor entity. The hypercalcemia is not clearly understood but may be related, in one case, with a high N terminal PTH serum level. Ultrastructural elements (secretory granules) and polypeptide hormone products (glucagon) are discussed in relation with APUD cells characteristics.
D000818:Animals; D001859:Bone Neoplasms / Q000556:secondary*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000150:complications*; D007223:Infant; D007680:Kidney Neoplasms / Q000150:complications / Q000175:diagnosis / Q000648:ultrastructure*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation