Synthesis of a heparinized poly(organophosphazene).
The synthesis of a new potential anti-thrombogenic polymer is described. Limited halogenation of an aryloxy-substituted polyphosphazene, followed by quaternization with triethylamine yielded a polymer capable of forming polyelectrolyte complexes with sodium heparin. The results of preliminary clotting tests with bovine blood are presented.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D002417:Cattle; D003692:Delayed-Action Preparations; D006493:Heparin; D009570:Nitriles / Q000138:chemical synthesis / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D011108:Polymers / Q000138:chemical synthesis* / Q000494:pharmacology; D014914:Whole Blood Coagulation Time
D003692:Delayed-Action Preparations; D009570:Nitriles; D009943:Organophosphorus Compounds; D011108:Polymers; D006493:Heparin