Benefits of the sperm (hamster ova) penetration assay in the evaluation of the infertile couple.
The males of 310 infertile couples and 30 control couples (current pregnancy) were evaluated with the sperm (hamster ova) penetration assay (SPA) and seminal fluid analysis (SFA). The SPA was found to have a sensitivity of 100% and a specificity of 97% compared to 41% and 90%, respectively, for the SFA. The highest degree of concordance of the two tests existed when both tests were abnormal and no female factor was identified. The poorest concordance occurred when the SFA was normal and no female infertility factor was identified. In almost all cases of unexplained infertility where no female infertility factor was present, the problem could be assigned to the man, as evidenced by an abnormal SPA. The SFA seemed to have some predictive value with respect to the outcome following treatment of the man.
D000818:Animals; D006224:Cricetinae; D005260:Female; D005306:Fertilization; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis*; D008297:Male; D011247:Pregnancy; D011379:Prognosis; D012661:Semen / Q000032:analysis; D013076:Sperm Count; D013084:Sperm-Ovum Interactions