[Activity of di-N-hydroxyquinoxaline and depot-sulfanilamide derivatives in experimental NAG infection].
In experiments in vitro dioxidineeee was highly effective as regards all the test cultures of NAG-vibrios. The MTC ranged within 1 to 62 micrograms/ml. Bactericidal action of the drug became manifest at concentrations from 4 to 250 micrograms/ml. The derivatives of di-N-oxide quinoxaline, dioxidin and quinoxidine exerted a chemotherapeutic effect and sterilizing action in experimental NAG-infection. The action of the drugs was potentiated upon combined use with lysozyme. As far as depo-sulfanilamides are concerned, sulfalenee was little active, while sulfamonomethoxine ineffective in experimental NAG-infection.
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D051379:Mice; D009113:Muramidase / Q000627:therapeutic use; D011810:Quinoxalines / Q000627:therapeutic use*; D013415:Sulfalene / Q000627:therapeutic use*; D013422:Sulfamonomethoxine / Q000627:therapeutic use*; D013424:Sulfanilamides / Q000627:therapeutic use*; D014735:Vibrio Infections / Q000188:drug therapy* / Q000382:microbiology
D000890:Anti-Infective Agents; D003692:Delayed-Action Preparations; D011810:Quinoxalines; D013424:Sulfanilamides; C003286:quinoxidine; C001077:dioxidine; D009113:Muramidase; D013415:Sulfalene; D013422:Sulfamonomethoxine
Aktivnost' proizvodnykh di-N-oksikhinoksalina i depo-sil'fanilamidov pri éksperimental'noĭ NAG-infektsii.