[Ratio of the depressive effect of macromolecular synthetic inhibitors in the mitochondria to the concentration of gonadotropic hormones in the in vitro maturation of Xenopus oocytes].
The inhibitory action of ethidium bromide (EthBr) and chloramphenicol (CM) on in vitro oocyte maturation in Xenopus laevis induced by different gonadotropic hormone concentrations was studied. Two concentrations of hormone were used (hypophysial suspension of HCG): one yielding high but not maximal incidence of maturation and another exceeding 4 to 8 times the former. Under the higher hormone concentration the inhibitory action of CM decreased and that of EthBr increased.
D000818:Animals; D002701:Chloramphenicol / Q000494:pharmacology*; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004996:Ethidium / Q000494:pharmacology*; D005260:Female; D046911:Macromolecular Substances; D009865:Oocytes / Q000187:drug effects* / Q000254:growth & development; D010063:Ovum / Q000187:drug effects*; D010902:Pituitary Gland; D013535:Suspensions; D014020:Tissue Extracts / Q000494:pharmacology*; D014982:Xenopus laevis
D006063:Chorionic Gonadotropin; D046911:Macromolecular Substances; D013535:Suspensions; D014020:Tissue Extracts; D002701:Chloramphenicol; D004996:Ethidium
Zavisimost' podavliaiushchego vliianiia ingibitorov makromolekuliarnykh sintezov v mitokhondriiakh ot kontsentratsii gonadotropnykh gormonov pri sozrevanii in vitro ootsitov ksenopusa.