Elicitation of delayed-type hypersensitivity to phosphorylcholine by monoclonal anti-idiotypic antibodies in an allogeneic environment.
Delayed-type hypersensitivity (DTH) to phosphorylcholine (PC) could be elicited by mixtures of monoclonal anti-idiotypic antibodies. Using this system in DTH transfers, the question was asked of whether anti-idiotypic antibodies could elicit antigen induced DTH in H-2-incompatible mice. Transfer of PC-activated BALB/c lymph node cells into BALB.K mice and subsequent elicitation with anti-idiotypic antibodies resulted in a positive DTH response. In contrast, elicitation with the antigen PC showed the expected H-2 restriction.
D000818:Animals; D000911:Antibodies, Monoclonal; D002794:Choline / Q000031:analogs & derivatives*; D003520:Cyclophosphamide / Q000494:pharmacology; D006968:Hypersensitivity, Delayed; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D010767:Phosphorylcholine / Q000276:immunology*; D013045:Species Specificity
D000911:Antibodies, Monoclonal; D007130:Immunoglobulin Idiotypes; D010767:Phosphorylcholine; D003520:Cyclophosphamide; D002794:Choline