Studies on the effect of fenbufen and sulindac on type II collagen-induced arthritis in rats.
The effect of fenbufen and sulindac, two novel antiinflammatory agents, on the developing and established lesion of type II collagen arthritis was investigated. Using paw diameter and radiology as parameters, these studies suggest that fenbufen is more efficacious than sulindac in this model.
D000818:Animals; D000893:Anti-Inflammatory Agents; D001168:Arthritis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D003094:Collagen; D007192:Indenes / Q000494:pharmacology*; D008297:Male; D010654:Phenylbutyrates; D011422:Propionates / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013467:Sulindac / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D007192:Indenes; D010654:Phenylbutyrates; D011422:Propionates; D013467:Sulindac; D003094:Collagen; C010725:fenbufen