Prazosin first dose phenomenon during combined treatment with a beta-adrenoceptor blocker in hypertensive patients.
1 The antihypertensive effect of prazosin has been studied in three groups of hypertensive patients. 2 The drug caused a significant reduction of blood pressure both as monotherapy and combined with alprenolol. 3 The effect of prazosin on blood pressure was more marked at the first dose and especially in combination with alprenolol. 4 No pharmacokinetic interaction between prazosin and alprenolol was observed. 5 Prazosin exhibits an exaggerated first dose effect together with alprenolol. Smaller starting doses of prazosin in combination therapy with beta-adrenoceptor blockers are warranted.
D000328:Adult; D000526:Alprenolol / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011224:Prazosin / Q000627:therapeutic use*; D011485:Protein Binding; D011799:Quinazolines / Q000627:therapeutic use*
D011799:Quinazolines; D000526:Alprenolol; D011224:Prazosin