Uptake, distribution, and anabolism of acyclovir in herpes simplex virus-infected mice.
The uptake, distribution, and anabolism of the nucleoside analog 9-(2-hydroxyethoxymethyl) guanine (acyclovir) were compared in herpes simplex virus-infected and uninfected mice. Analyses of tissue distribution and the concentration of acyclovir after either a single dose or multiple doses failed to reveal significant differences between drug levels in infected and uninfected animals. Extracts of tissues from [8-14C] acyclovir-treated animals were examined by high-performance liquid chromatography to detect the presence of any phosphorylated forms of the drug. The sensitivity of this method did not allow a reproducible demonstration of acyclovir anabolism in herpes simplex virus-infected tissues owing to the low numbers of infected cells per organ.
D000212:Acyclovir; D000818:Animals; D000998:Antiviral Agents / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D005260:Female; D006147:Guanine / Q000031:analogs & derivatives* / Q000378:metabolism; D006561:Herpes Simplex / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D014018:Tissue Distribution
D000998:Antiviral Agents; D006147:Guanine; D000212:Acyclovir