Hormones, salt, hypertension and the interstitium. Is the interstitium the missing link?
The pathophysiology of most forms of hypertension is still poorly understood. A hypothesis is developed suggesting that the balance of hormones capable of influencing sodium metabolism play a significant role in the pathophysiology of hypertension, and that a significant component of the hormonal effect is mediated through changes in the interstitial matrix. It is suggested that the interstitial changes play a direct role in the increase in blood pressure and in bringing about many of the observed differences between hypertensive and normotensive states.
D000818:Animals; D006728:Hormones / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D011388:Prolactin / Q000502:physiology; D011509:Proteoglycans / Q000502:physiology; D012964:Sodium / Q000378:metabolism*; D014882:Water-Electrolyte Balance
D006728:Hormones; D011509:Proteoglycans; D011388:Prolactin; D012964:Sodium