Glycosylated hemoglobins (GHb): an index of red cell survival.
Levels of glycosylated hemoglobins (GHb) are significantly (p less than 0.0005) lower in patients with hemolytic anemia (n = 20; mean = 3.9% +/- 0.1% SD GHb of total Hb) compared to patients with nonhemolytic anemia (n = 20; mean = 7.0% +/- 0.7% GHb) and normal controls (n = 30; mean = 6.7% +/- 0.7% GHb). A curvilinear correlation between GHb and red cell survival is demonstrable (n = 20;r2 = 0.88; p less than 0.001). Determination of GHb may be useful as a screening test for hemolytic anemia and for the evaluation of the degree of hemolysis, provided that diabetes mellitus can be excluded.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000740:Anemia / Q000097:blood*; D000743:Anemia, Hemolytic / Q000097:blood; D004905:Erythrocyte Aging; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D013103:Spherocytosis, Hereditary / Q000097:blood
D006442:Glycated Hemoglobin