Lipofuscin pigment accumulation in the central nervous system of the mouse during aging.
Histopathological and autofluorescence investigations were carried out to study lipofuscin pigment accumulation in various age groups of mice. Qualitative studies revealed an increase of lipofuscin pigment accumulation in old animals. Quantitative studies showed a significant increase in the percentage of pigmented nerve cells and the percentage of cytoplasmic areas occupied by lipofuscin pigment granules with advancing age.
D000375:Aging; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D003594:Cytoplasmic Granules / Q000378:metabolism; D005260:Female; D008062:Lipofuscin / Q000378:metabolism*; D051379:Mice; D008805:Mice, Inbred A; D008856:Microscopy, Fluorescence; D009474:Neurons / Q000378:metabolism; D010860:Pigments, Biological / Q000378:metabolism*
D008062:Lipofuscin; D010860:Pigments, Biological