Transient alteration of theophylline half-life: possible association with Herpes simplex infection.
Transient alteration of theophylline half-life resulting in theophylline neurotoxicity is reported in a nine-year-old child. The alteration in theophylline elimination half-life was associated with Herpes simplex gingivostomatitis. This association has not previously been demonstrated. The report is contrasted with a study of theophylline clearance variability in children.
D001249:Asthma / Q000378:metabolism; D002648:Child; D006207:Half-Life; D006801:Humans; D008297:Male; D013283:Stomatitis, Herpetic / Q000378:metabolism*; D013806:Theophylline / Q000378:metabolism* / Q000633:toxicity
D013806:Theophylline