[Chronotherapy of obesity. II. Variations in eating behavior in the obese after fenfluramine treatment in relation to time of administration].
The administration of Fenfluramine (F.) in a single dose in the morning provokes a different effect on eating behavior (E.B.) in comparison with the administration of the same dose three times/day. It is observed a shorter duration of eating (p less than 001); a decrease of total kcalories ingested during the day, and hunger feeling. These results are reviewed on the basis of present knowledge on drug-kinetic and on previous work in our laboratory which documented higher decrease of body weight and adipose mass when the F. was administered in a single dose in the morning than in the afternoon or three times a day.
D000328:Adult; D001066:Appetite / Q000187:drug effects; D004334:Drug Administration Schedule; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D005277:Fenfluramine / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D006801:Humans; D007700:Kinetics; D009765:Obesity / Q000188:drug therapy*
D005277:Fenfluramine
Cronoterapia dell "obesita'. II. Variazioni del comportamento nell'assunzione del cibo in obesi sottoposti a trattamento con fenfluramina in relazione all'ora di somministrazione.