Classic gout in Hageman factor (Factor XII) deficiency.
A 62-year-old man with a typical history of gout was admitted to the hospital with left-sided hemiplegia. His serum uric acid level was 10.3 mg/dL, his partial thromboplastin time was 198 s, and his Hageman factor (factor XII) coagulant activity and antigen were less than 1% of normal. Aspiration of synovial fluid from his inflamed knee disclosed urate crystals and abundant leukocytes but an absence of Hageman factor antigen. The presence of acute gouty arthritis in a patient with Hageman trait challenges the role of Hageman factor in the pathogenesis of gouty arthropathy.
D005121:Extremities; D005174:Factor XII; D005175:Factor XII Deficiency; D006073:Gout / Q000150:complications* / Q000378:metabolism; D006801:Humans; D007705:Kinins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D013582:Synovial Fluid / Q000032:analysis
D007705:Kinins; D005174:Factor XII