Acyclovir treatment of experimental herpetic keratitis in the rabbit eye.
In the rabbit eye model of experimental herpetic keratitis a satisfactory cure was obtained with ointments containing 1 percent, 2 percent, and 3 percent acyclovir, and also with idoxuridine. Trifluorothymidine and vidarabine were less effective in the particular conditions of the experiment. A cure was also obtained with acyclovir sodium salt injected intravenously, thus demonstrating that a local infection of the eye can be treated systematically.
D000212:Acyclovir; D000287:Administration, Topical; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006147:Guanine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007065:Idoxuridine / Q000627:therapeutic use; D007275:Injections, Intravenous; D007635:Keratitis, Dendritic / Q000188:drug therapy*; D009883:Ophthalmic Solutions; D011817:Rabbits; D014740:Vidarabine / Q000627:therapeutic use
D000998:Antiviral Agents; D009883:Ophthalmic Solutions; D006147:Guanine; D014740:Vidarabine; D007065:Idoxuridine; D000212:Acyclovir