Chemical modification of everninomicins.
Novel antibiotic everninomicin D is chemically transformed into new biologically active derivatives. Reactions of a nitro group attached to a tertiary carbon center have been investigated. Synthesis and reactions of hydroxylaminoeverninomicin D, aminoeverninomicin D and their derivatives have been discussed.
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D055598:Chemical Phenomena; D002621:Chemistry; D004355:Drug Stability; D006027:Glycosides / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D006027:Glycosides; C001202:evernimicin