Lesions of the dorsal noradrenergic bundle and rewarded running: the role of pretraining.
Local injection of 6-hydroxydopamine was used to selectively destroy the dorsal ascending noradrenergic bundle (DB), producing 75% loss of hippocampal noradrenaline. Lesioned and control rats were trained to run in a straight alley for food reward with or without pretraining (handling and habituation to the apparatus). Lesioned rats ran more slowly than controls only if they had not been pretrained. This result may explain previous discrepancies in the literature; it is discussed in relation to existing hypotheses of DB function.
D000818:Animals; D003216:Conditioning, Operant / Q000502:physiology*; D005108:Extinction, Psychological / Q000502:physiology; D006185:Habituation, Psychophysiologic / Q000502:physiology; D006234:Handling, Psychological; D008125:Locus Coeruleus / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology*; D011214:Practice, Psychological; D051381:Rats; D011919:Rats, Inbred Strains; D012201:Reward
D009638:Norepinephrine