Comparative and developmental studies on 4-hydroxy-2-oxoglutarate aldolase and hydroxyproline oxidase.
1. In rats, liver 4-hydroxy-2-oxoglutarate aldolase and hydroxyproline oxidase activities are maximal in the suckling period. 2. Liver activities for 4-hydroxy-2-oxoglutarate aldolase, alanine-glyoxylate aminotransferase, serine-pyruvate aminotransferase and serine dehydratase, but not hydroxyproline oxidase, are increased in rats on a high-fat, carbohydrate-free diet. 3. It is suggested that 4-hydroxy-2-oxoglutarate may be a significant source of glyoxylate for glycine and hence glucose formation. 4. Mammalian liver hydroxyproline oxidase activity is higher in carnivorous species; necessary, perhaps, to metabolise a relatively large influx of hydroxyproline on a flesh diet.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D002415:Cats; D006224:Cricetinae; D004285:Dogs; D005260:Female; D005289:Ferrets; D005333:Fetus; D007656:Ketoglutaric Acids / Q000378:metabolism; D007668:Kidney / Q000201:enzymology / Q000254:growth & development; D008099:Liver / Q000201:enzymology / Q000254:growth & development; D008297:Male; D008647:Mesocricetus; D051379:Mice; D009928:Organ Specificity; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000378:metabolism*; D007652:Oxo-Acid-Lyases / Q000378:metabolism*; D011247:Pregnancy; D011817:Rabbits; D011898:Ranidae; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013552:Swine
D007656:Ketoglutaric Acids; D000587:Oxidoreductases Acting on CH-NH Group Donors; C034575:hydroxyproline oxidase; D007652:Oxo-Acid-Lyases; C021415:4-hydroxy-2-oxoglutarate aldolase