[Effect of morphine on dopamine and 5-HT content of the caudate nucleus in the guinea pig].
The effect of Morphine (3 x 10(-6) - 3 x 10(-5)) on tissue Dopamine and 5-hydroxytryptamine content was studied in superfused slices of guniea-pig caudate nucleus kept at rest or stimulated for 30 min at 5 Hz. The caudatal slices submitted to electrical stimulation for 30 min showed a significant reduction in their 5-hydroxytryptamine and Dopamine content. Morphine did not modify the amines content of the slices kept at rest but counteracted the depletion caused by electrical stimulation. The opioid was dose-dependent and antagonized by Naloxone 1 x 10(-5) M.
D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D009270:Naloxone; D009020:Morphine; D004298:Dopamine
Effetto della morfina sul contenuto di dopamina e 5-HT in fettine di nucleo caudato di cavia.