[Polyene antibiotics stability, study of the rate of the heterogeneous destruction of the hepataene antibiotic levorin by an "accelerated aging" method and the possibility of predicting the shelf life of levorin].
The data on stability of levorin of various purity levels stored under natural conditions and under conditions of thermic rapid inactivation are presented. When the ratio of oxygen to the antibiotic was 1 mole/1 mole the kinetic inactivation curve was of a multistage character with periods of active destruction and quasistatic state. The use of thermic inactivation as a method of accelerated aging is substantiated. A procedure for calculation of the expiry date of the antibiotic is described.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002174:Candicidin / Q000494:pharmacology*; D004355:Drug Stability; D004356:Drug Storage; D007700:Kinetics; D008433:Mathematics; D011090:Polyenes / Q000494:pharmacology*; D011379:Prognosis; D013696:Temperature; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011090:Polyenes; D002174:Candicidin
Stabil'nost' polienovykh antibiotikov, izuchenie skorosti geterogennoĭ destrucktsii gepatenovogo antibiotika levorina metodom "uskorennogo stareniia" i vozmozhnost' prognozirovaniia sroka khraneniia levorina.