Specific immunosuppression of IgE response to hapten DNP by linked to monoclonal IgG1 in rats.
The induction of the anti-DNP IgE in rat was suppressed by pretreatment of rats with the tolerogen synthesized by coupling DNP to rat IgG, i.e.; DNP7-10-IgG. It was found that DNP10-IgG1 was an effective tolerogen, whereas other DNP conjugates, i.e. DNP9-IgM, DNP9-IgA, DNP10-IgE, DNP10-IgG2c and DNP10-IgG2a were ineffective.
D000818:Animals; D000911:Antibodies, Monoclonal; D004140:Dinitrophenols / Q000494:pharmacology; D006241:Haptens; D007073:Immunoglobulin E / Q000276:immunology*; D007165:Immunosuppression Therapy; D007700:Kinetics; D051381:Rats
D000911:Antibodies, Monoclonal; D004140:Dinitrophenols; D006241:Haptens; D007073:Immunoglobulin E