Independent segregation of NZB immune abnormalities in NZB x C58 recombinant inbred mice.
The study of NZB x C58 recombinant inbred mouse strains has revealed independent segregation of naturally occurring thymocytotoxic antibody and Coombs' anti-erythrocyte autoantibody. The lack of concordance of either of these autoantibodies with known heavy and light chain markers suggests that the autoantibodies are produced as a result of regulatory gene defects rather than alterations of antibody structural genes. Further, lack of concordance of the various autoimmune traits with each other or with H-2 or virus expression suggests that the autoimmune phenotype is not the result of a single "autoimmunity' gene but rather the outcome of faulty regulation of a number of independently segregating genes.
D000375:Aging; D000818:Animals; D000961:Antilymphocyte Serum / Q000235:genetics / Q000276:immunology; D001323:Autoantibodies / Q000096:biosynthesis* / Q000235:genetics; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology; D003433:Crosses, Genetic; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB / Q000235:genetics / Q000276:immunology*; D011995:Recombination, Genetic
D000961:Antilymphocyte Serum; D001323:Autoantibodies