[Effect of obesity on the elevation of renal glucose threshold. Studies during oral glucose tolerance tests (author's transl)].
To estimate the renal glucose threshold, we measured glucosuria in 546 oral glucose tolerance tests (OGTT) (glucose oxidase method). The subjects, with normal renal function, presented during OGTT one or several peak plasma glucose levels between 10 and 13.4 mmol/l. The renal glucose threshold was thus higher than 10 mmol/l in the 43% of this population who were a glucosuric (normal renal threshold was between 8.8 and 10 mmol/l). The frequency of raised threshold was higher in obese patients than in subjects of normal body weight: indeed from 34% in non obese patients rates rose respectively at 37%, 50% and 68% in obesity groups (10 to 30%, 30 to 50% and 50% over ideal body weight (respectively). This trend was found regardless of the type of glucose tolerance response (ie. normal, IGT, non diagnostic, NIDD).
D001786:Blood Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D006029:Glycosuria / Q000652:urine*; D006801:Humans; D009765:Obesity / Q000652:urine*
D001786:Blood Glucose
Influence de l'obésité sur la fréquence d'élévation du seuil rénal d'élimination du glucose. Etude au cours d'épreuves de tolérance au glucose.