Genetic effects in the mouse of formaldehyde in combination with adenosine and hydrogen peroxide.
Male mice of the Q strain were injected (i.p.) with a synthetic methylene dinucleotide (Ado-CH2-Ado) and with a mixture of formaldehyde and hydrogen peroxide. Neither injection induced any chromosome lesions in spermatogonia. In the dominant lethal mutation test, the mixture of formaldehyde and hydrogen peroxide had an effect throughout spermatogenesis, but only the rate of pre-implantation losses was increased. Injection of Ado-CH2-Ado increased both pre-and post-implantation deaths at the 1st week but only the frequency of pre-implantation losses at the 6th week.
D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D005260:Female; D005306:Fertilization / Q000187:drug effects; D005557:Formaldehyde / Q000494:pharmacology*; D005799:Genes, Dominant / Q000187:drug effects*; D005804:Genes, Lethal / Q000187:drug effects*; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D011247:Pregnancy; D013091:Spermatogenesis / Q000187:drug effects*; D013093:Spermatogonia / Q000187:drug effects
D009153:Mutagens; D005557:Formaldehyde; D006861:Hydrogen Peroxide; D000241:Adenosine