Chemotherapy for tumours using clostridial oncolysis, antibiotics and cyclophosphamide: model trial on the UVT 15264 tumour.
Lysis of the UVT 15264 tumour in mice of the 17/Berlin-Buch strain as induced by intravenous injection of Clostridium butyricum H8 spores is followed by the tumour diameter and survival time. In animals thus treated, tumour regression is incomplete and the mean survival time drops below that of tumour-bearing animals not treated with spores. With concurrent antibiotic treatment survival time is prolonged to exceed that of untreated animals, without affecting ocolysis-provoked tumour regression. When spore is combined with cyclophosphamide, tumour regression is considerably improved, but the survival resembles that of untreated tumour-bearing animals; with both cyclophosphamide and antibiotic treatment survival resembles that of spore-treated animals.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D003013:Clostridium / Q000378:metabolism*; D003520:Cyclophosphamide / Q000627:therapeutic use*; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000401:mortality; D013171:Spores, Bacterial / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D003520:Cyclophosphamide