Comparative study of 99mTc labeled hepatobiliary agents based on naphthalene and similar ring systems.
A series of 99mTc complexes of naphthalene and naphthalene-like ring systems were evaluated pharmacokinetically as hepatobiliary imaging agents and compared to 131I-rose bengal and 99mTc-N-(2,6-diethylacetanilide)-iminodiacetate in rats and dogs. Although all complexes studied exhibited high specificity for biliary excretion, they varied widely in disappearance rate from blood and in biliary excretion. Complexes with 8-hydroxyquinoline-7-carboxylic acid and hydralazine were relatively lipophilic and were eliminated more slowly than 131I-rose bengal; complexes of iminodiacetic derivatives of naphthalene, N-(2-acetylnaphthyl)iminodiacetic acid N-(2-naphthylmethyl)iminodiacetic acid were more polar and were eliminated much faster. Renal excretion of the complexes was 5.6% or less except for that of the latter compound (18%). Plasma binding ranged from 51 to 98%.
D000818:Animals; D001659:Biliary Tract / Q000000981:diagnostic imaging*; D004285:Dogs; D006830:Hydralazine; D006912:Hydroxyquinolines; D007098:Imino Acids; D007457:Iodine Radioisotopes; D009281:Naphthalenes; D015609:Organotechnetium Compounds; D011817:Rabbits; D011877:Radionuclide Imaging; D051381:Rats; D012395:Rose Bengal; D013329:Structure-Activity Relationship; D013667:Technetium; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid; D013997:Time Factors
D006912:Hydroxyquinolines; D007098:Imino Acids; D007457:Iodine Radioisotopes; D009281:Naphthalenes; D015609:Organotechnetium Compounds; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid; C034926:technetium Tc 99m N-(2-acetylnaphthyl)iminodiacetic acid; C034925:technetium Tc 99m N-(2-naphthylmethyl)iminodiacetic acid; C034927:technetium Tc 99m-8-hydroxyquinoline-7-carboxylic acid; D012395:Rose Bengal; D006830:Hydralazine; D013667:Technetium