Brain spectrin, a membrane-associated protein related in structure and function to erythrocyte spectrin.
An immunoreactive analogue of erythrocyte spectrin has been purified from brain membranes. This protein co-sediments with and cross-links actin filaments, associates with spectrin-binding sites on erythrocyte membranes, and has been visualized by rotary shadowing as an extended, flexible rod. The brain spectrin comprises 3% of the total membrane protein, and may have a major role in mediating linkage of actin to membranes.
D000199:Actins / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry; D002462:Cell Membrane / Q000032:analysis; D004910:Erythrocyte Membrane / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000302:isolation & purification*; D009419:Nerve Tissue Proteins / Q000302:isolation & purification*; D010455:Peptides / Q000032:analysis; D011487:Protein Conformation; D013049:Spectrin / Q000031:analogs & derivatives / Q000276:immunology / Q000302:isolation & purification*; D013552:Swine
D000199:Actins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D010455:Peptides; D013049:Spectrin