[Contributions to the liberation of drugs from suspension ointments. Part 19: Studies on the interactions of hydroxyquinoline (salts) with ointment components (author's transl)].
On studying the interactions of hydroxyquinoline and its watersoluble salts with substances commonly used to ointment preparation, the authors stated a large agreement between the decreases in release rate and the quotients of binding determined by equilibrium dialysis. Sodium carboxymethyl cellulose, zinc oxide, and talc react with these drugs to form bindings of some strength the impair the release of the drugs, whereas hydroxyethylcellulose and Aerosil behave indifferently.
D002626:Chemistry, Pharmaceutical; D003956:Dialysis; D004344:Drug Incompatibility; D005079:Excipients; D006912:Hydroxyquinolines; D009824:Ointments; D013535:Suspensions
D005079:Excipients; D006912:Hydroxyquinolines; D009824:Ointments; D013535:Suspensions
Beiträge zur Arzneistoff-Liberation aus Suspensionssalben. 19. Mitteilung: Untersuchungen zu Wechselwirkungen von Hydroxychinolin (-salzen) mit Salbenbestandteilen.