Hormonal control of 5 alpha-reductase activity in hamster sebaceous glands.
The effect of castration on total 5 alpha-reductase activity in transforming testosterone to 5 alpha-reduced metabolites was studied in the sebaceous gland of male hamsters. The mean enzyme activity increased to more than twice the control level as early as 4 days after castration and this increase remained almost unchanged at 14, 21 and 63 days after castration. The administration of testosterone propionate or 5 alpha-dihydrotestosterone to castrates led to a complete inhibition of the increase in enzyme activity and this inhibitory effect was blocked by cyproterone acetate. These data indicate that androgens may be regulators of 5 alpha-reductase activity in the sebaceous gland of hamsters.
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000378:metabolism*; D000728:Androgens / Q000502:physiology*; D000818:Animals; D002369:Castration; D006224:Cricetinae; D013196:Dihydrotestosterone / Q000494:pharmacology; D008297:Male; D008647:Mesocricetus; D010088:Oxidoreductases / Q000378:metabolism*; D012627:Sebaceous Glands / Q000187:drug effects / Q000201:enzymology*; D013739:Testosterone / Q000494:pharmacology
D000728:Androgens; D013196:Dihydrotestosterone; D013739:Testosterone; D010088:Oxidoreductases; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase