Bone growth during chronic aldrin intoxication in goats.
Microscopic examination of the costochondral junction of goats after chronic aldrin intoxication revealed a drastic reduction in the width of proliferating, maturing and degenerating cartilage cells. The zone of provisional calcification was almost negligible in aldrin treated animals. In contrast, the control animals showed an orderly sequence of endochondral bone formation. Appositional bone growth studied by the tetracycline labelling technique also showed a marked reduction following chronic aldrin intake. It was concluded that decrease in the rate of appositional bone growth at endosteal periosteal and osteonic surfaces might be due to poor synthesis of bone matrix by the osteoblasts.
D000452:Aldrin / Q000633:toxicity*; D000818:Animals; D001846:Bone Development / Q000187:drug effects*; D002118:Calcium / Q000097:blood; D005260:Female; D006041:Goats / Q000254:growth & development*; D010758:Phosphorus / Q000097:blood; D012272:Ribs / Q000254:growth & development
D010758:Phosphorus; D000452:Aldrin; D002118:Calcium