Protective effects of butylated hydroxyanisole, ethoxyquin, and disulfiram on acute pyrrolizidine alkaloids poisoning in mice.
Administration of butylated hydroxyanisole (BHA), ethoxyquin (EQ), and disulfiram (DSF) in the diet for 7 days reduced the acute toxicity of pyrrolizidine alkaloids isolated from Senecio longilobus. The LD50 values of the BHA- and EQ-fed mice were about twofold of the controls but the protective effect of DSF was inferior to that of either BHA or EQ.
D000818:Animals; D000840:Anisoles / Q000494:pharmacology*; D002083:Butylated Hydroxyanisole / Q000494:pharmacology*; D004221:Disulfiram / Q000494:pharmacology*; D004347:Drug Interactions; D005015:Ethoxyquin / Q000494:pharmacology*; D007928:Lethal Dose 50; D051379:Mice; D011763:Pyrrolizidine Alkaloids / Q000037:antagonists & inhibitors* / Q000506:poisoning; D011804:Quinolines / Q000494:pharmacology*; D013997:Time Factors
D000840:Anisoles; D011763:Pyrrolizidine Alkaloids; D011804:Quinolines; D002083:Butylated Hydroxyanisole; D005015:Ethoxyquin; D004221:Disulfiram