Stability of antimicrobial agents in peritoneal dialysate.
The stability of cephapirin, gentamicin, penicillin G, nafcillin, ticarcillin, and vancomycin was tested in peritoneal dialysate at 25 degrees C for 24 h. All of the antimicrobial agents were stable except penicillin G, which lost 25% of activity over 24 h (P less than 0.01). The once-daily preparation of drug-dialysate solution is feasible for the treatment of peritonitis in patients on continuous ambulatory peritoneal dialysis.
D000900:Anti-Bacterial Agents / Q000032:analysis*; D004355:Drug Stability; D010530:Peritoneal Dialysis
D000900:Anti-Bacterial Agents