Pancytopenia with mixed cryoglobulinemia: evidence for anti-percursor cell activity of cryoglobulin--effects of plasmapheresis.
The efficacy of plasmapheresis in a patient with mixed cryoglobulinemia and pancytopenia is shown. The cryoglobulin was shown to have percursor cell suppressing activity and its depletion by plasmapheresis resulted in improvement of blood counts, Indications, limitations and guidelines for plasmapheresis in various diseases are discussed.
D000368:Aged; D000818:Animals; D002452:Cell Count; D003114:Colony-Forming Units Assay; D003449:Cryoglobulinemia / Q000150:complications* / Q000276:immunology / Q000628:therapy; D003450:Cryoglobulins / Q000494:pharmacology*; D006168:Guinea Pigs; D006412:Hematopoietic Stem Cells; D006801:Humans; D008297:Male; D010198:Pancytopenia / Q000150:complications* / Q000276:immunology / Q000628:therapy; D010265:Paraproteinemias / Q000150:complications*; D010956:Plasmapheresis
D003450:Cryoglobulins