Maturation of potassium-stimulated respiration in rat cerebral cortical slices.
Maximal dinitrophenol-stimulated respiration and K+-stimulated respiration were measured polarographically in cerebral cortical slices taken from rats aged 2-60 days. Increasing K+ concentrations produced an increase in respiration in slices from animals aged 15 days and older, but not in slices from animals aged 10 days and younger. Dinitrophenol-stimulated respiration, or the maximal respiratory capacity of the tissue, showed a similar increase between 10 and 15 days of age. At each age the maximal respiratory capacity was 6-8 ng at 0/mg protein min greater than the maximal K+-stimulated respiration.
D019297:2,4-Dinitrophenol; D000375:Aging; D000818:Animals; D002540:Cerebral Cortex / Q000254:growth & development* / Q000378:metabolism; D004140:Dinitrophenols / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D010101:Oxygen Consumption / Q000187:drug effects*; D011189:Potassium Chloride / Q000494:pharmacology*; D051381:Rats
D004140:Dinitrophenols; D011189:Potassium Chloride; D019297:2,4-Dinitrophenol