Detoxification of cyanide in a new-born child.
A well-developed male baby was given infusions of 2-5 microgram/kg/min of sodium nitroprusside (SNP) in the first few days after birth on account of high arterial blood pressure. After 30 h of treatment, cyanide accumulation was found to have reached a life-threatening level. IV administration of 100 mg/kg of sodium thiosulphate promptly lowered the cyanide level. The mixed infusion of SNP together with thiosulphate, used in the subsequent course, was no longer toxic.
D000931:Antidotes / Q000627:therapeutic use*; D005292:Ferricyanides / Q000506:poisoning*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy; D008297:Male; D009599:Nitroprusside / Q000506:poisoning* / Q000627:therapeutic use; D013885:Thiosulfates / Q000627:therapeutic use*
D000931:Antidotes; D005292:Ferricyanides; D013885:Thiosulfates; D009599:Nitroprusside; C017717:sodium thiosulfate