Decrease of carbon tetrachloride liver toxicity in rats given dipyridamole.
The influence of Dipyridamole on acute hepatotoxicity has been studied in male SD-JCL rats doses with carbon tetrachloride. High single oral doses of Dipyridamole lowered the serum enzyme activity and reduced significantly the area % of hepatic necrosis and hydropic degeneration, but not of steatosis. Dipyridamole was effective from 1 hr before through 6 hrs after the oral administration of CCl4. Doses below 1,000 mg/kg Dipyridamole were less effective. No delay in the onset of CCl4-induced liver damages was observed. Dipyridamole was also effective when CCl4 toxicity was enhanced by isopropanol.
D000433:1-Propanol / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002251:Carbon Tetrachloride / Q000037:antagonists & inhibitors / Q000633:toxicity*; D004176:Dipyridamole / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009336:Necrosis; D051381:Rats
D004176:Dipyridamole; D000433:1-Propanol; D002251:Carbon Tetrachloride