Evidence of altered structure of the erythrocyte membrane in spontaneously hypertensive rats.
1. The membrane structure of erythrocytes of rats with different forms of arterial hypertension was studied by means of two hydrophobic fluorescent probes (diphenylhexatriene and pyrene). 2. Microviscosity of hydrophobic areas of erythrocyte membrane of spontaneously hypertensive rats was found to be increased compared with that of membranes from normotensive control rats. 3. No alterations of membrane structure of erythrocytes of deoxycorticosterone-treated rats and renal hypertensive rats were found.
D000818:Animals; D003900:Desoxycorticosterone; D004161:Diphenylhexatriene; D004910:Erythrocyte Membrane / Q000473:pathology*; D004912:Erythrocytes / Q000473:pathology*; D005260:Female; D005454:Fluorescence Polarization; D006973:Hypertension / Q000097:blood* / Q000139:chemically induced; D006977:Hypertension, Renal / Q000097:blood; D008297:Male; D011721:Pyrenes; D051381:Rats; D011919:Rats, Inbred Strains
D011721:Pyrenes; D004161:Diphenylhexatriene; D003900:Desoxycorticosterone