Convulsions associated with high cumulative doses of metronidazole.
Metronidazole in high cumulative doses has been associated with convulsions. A case is presented in which this relationship is clear. In all reported cases of metronidazole-associated seizures, the cumulative dose of metronidazole has been high (greater than 40 g). The cumulative dose rather than the serum level is important in the pathogenesis of this complication.
D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D012640:Seizures / Q000139:chemically induced*
D008795:Metronidazole