Levamisole and immune response phenomena in cutaneous leishmaniasis.
Levamisole has been successfully used therapeutically in twenty-eight cases of chronic cutaneous leishmaniasis. It is suggested that repeated sandfly bites not initiating a clinical lesion may immunize against later infection by the formation of blocking antibodies to Leishmania tropica or by denying the parasite a locus in which it can become established. Late-appearing lesions in natives of endemic areas should raise the suspicion of impaired immunity from systemic disease such as malignancy.
D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D002675:Child, Preschool; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007299:Insect Bites and Stings / Q000276:immunology; D007303:Insect Vectors; D007896:Leishmaniasis / Q000188:drug therapy / Q000276:immunology* / Q000635:transmission; D007978:Levamisole / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010691:Phlebotomus; D012529:Saudi Arabia
D007978:Levamisole