The choleretic effect of menbutone and clanobutin sodium in steers.
Adult steers were given either clanobutin or menbutone intravenously and the effects on bile flow measured. Doses of 4.3 g of clanobutin or 3.0 g of menbutone had no effect on bile flow. However, when bile flow was previously reduced by reducing the total bile salts in the enterohepatic circulation both compounds were potent choleretics, increasing the volume of bile flow up to four-fold.
D000818:Animals; D001646:Bile / Q000187:drug effects*; D001647:Bile Acids and Salts / Q000032:analysis; D002417:Cattle / Q000502:physiology*; D002756:Cholagogues and Choleretics / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009281:Naphthalenes / Q000008:administration & dosage / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D001647:Bile Acids and Salts; D002756:Cholagogues and Choleretics; D009281:Naphthalenes; C011497:menbutone; D005680:gamma-Aminobutyric Acid; C019159:clanobutin