Granulomatous hepatitis and cholangitis associated with giardiasis.
Biopsy of the liver revealed granulomas in portal tracts and cholangitis in a woman with chronic diarrhea, weight loss, fever, hypoalbuminemia, and anemia attributed to giardiasis. Eradication of Giardia resulted in rapid improvement of symptoms and resolution of histologic changes on a second biopsy of the liver after 3 mo. The patient had serum immunoglobulin levels that were either normal (IgG, IgM) or elevated (IgA), detectable levels in serum of anti-Giardia antibody, and an HLA phenotype (B12, B27) known to be associated with prolonged giardiasis.
D000906:Antibodies / Q000032:analysis; D005260:Female; D005873:Giardiasis / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006099:Granuloma / Q000209:etiology* / Q000473:pathology; D006680:HLA Antigens / Q000032:analysis; D006505:Hepatitis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D008099:Liver / Q000473:pathology; D008795:Metronidazole / Q000627:therapeutic use; D008875:Middle Aged; D010641:Phenotype
D000906:Antibodies; D006680:HLA Antigens; D007070:Immunoglobulin A; D008795:Metronidazole