Enhancement of the sensitivity of hamster check pouch arterioles to beta-adrenergic stimulus during pregnancy.
The adrenergic beta stimulant fenoterol induced a dose-dependent vasodilatation of hamster cheek pouch arterioles. The response to fenoterol was significantly larger on day 14 of pregnancy than in metoestrous animals. Since the serum progesterone and 17 beta-oestradiol level were also elevated on day 14, a relationship was suggested between the enhancement of vascular sensitivity and sex-steroid hormone levels.
D000818:Animals; D002610:Cheek / Q000098:blood supply / Q000187:drug effects; D006224:Cricetinae; D004958:Estradiol / Q000097:blood; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D005280:Fenoterol / Q000494:pharmacology*; D007700:Kinetics; D008647:Mesocricetus; D011247:Pregnancy; D011270:Pregnancy, Animal; D011374:Progesterone / Q000097:blood; D014664:Vasodilation / Q000187:drug effects*
D004983:Ethanolamines; D005280:Fenoterol; D011374:Progesterone; D004958:Estradiol