Effect of glutathione depletion on selenium lethality and hepatic drug metabolism in male rats.
Pretreatment of male rats with diethylmaleate (DEM) (3.1 mmol/kg) markedly decreased the levels of reduced glutathione in both liver (81%) and kidney (44%). Acute lethality produced by sodium selenite (0.4 to 2.4 mg Se/kg) was greatly enhanced in DEM-treated rats; however, no alterations in hepatic drug metabolism by selenium were observed.
D000818:Animals; D005978:Glutathione / Q000502:physiology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D008298:Maleates / Q000494:pharmacology; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium / Q000633:toxicity*
D008298:Maleates; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; C014476:diethyl maleate; D005978:Glutathione; D012643:Selenium