[The combination therapy of amikacin and beta-lactam antibiotic in the severe bacterial infections (author's transl)].
The combination therapy of beta-lactam and aminoglycoside antibiotics is now evaluated to be very effective in severe infections. Amikacin, one of aminoglycoside antibiotics, has antibacterial activity to gentamicin resistant bacteria. Then we tried to use the combination therapy of amikacin and beta-lactams in 20 cases with severe bacterial infections, including 2 cases of bacteremia etc. Fifteen cases out of them failed to cure by previous antibiotics treatment. With a few exception, amikacin was administered daily 200 mg in 2 divided intramuscular injections. beta-Lactams were administered twice a day by intravenous drip infusion, but dose and kind of beta-lactams were decided by attending doctors. Clinical efficacy of this combination therapy was classified in 4 degrees: excellent, good, fair and poor. Clinical efficacy rate (excellent and good results) in all cases was 75%. This is equally effective, compared with the newly sold antibiotics. Elevation of serum GOT and GPT levels was seen in 2 cases in whom large amount of PCs was given. As a conclusion, it was indicated that the combination therapy of amikacin and beta-lactam in the regular dose was sufficiently effective and useful for the therapy of severe bacterial infections.
D000328:Adult; D000368:Aged; D000583:Amikacin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007612:Kanamycin / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use
D010406:Penicillins; D007612:Kanamycin; D000583:Amikacin