[Experimental study of the allergenic action of a staphylococcal antigenic complex obtained by aqueous extraction compared to other staphylococcal preparations].
Anaphylactic and skin reactions in guinea pigs immunized with the antigenic staphylococcal complex obtained from strains showing different virulence of the strains has been shown to considerably affect the allergenic activity of the preparation. Similar results have been obtained by means of the model of paw edema in mice, and it has been shown that the staphylococcal antigenic complex produces a lesser allergenic effect than commercial adsorbed toxoid and formalin-treated corpuscular vaccine. In experiments carried out with the use of the model of septic infection in rabbits the preparations of the antigenic staphylococcal complex, obtained from less virulent strains and showing less pronounced allergenic effect in animals have been shown to be most immunogenic.
D000327:Adsorption; D000707:Anaphylaxis / Q000276:immunology; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology* / Q000302:isolation & purification; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D051379:Mice; D012882:Skin Tests; D013208:Staphylococcal Toxoid / Q000276:immunology*; D013209:Staphylococcal Vaccines / Q000276:immunology*; D013210:Staphylococcus / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000276:immunology
D000942:Antigens, Bacterial; D013208:Staphylococcal Toxoid; D013209:Staphylococcal Vaccines; D014613:Vaccines, Attenuated; C034359:antifagin
Eksperimental'noe izuchenie allergennogo deĭstviia antigennogo kompleksa stafilokokka, poluchennogo metodom vodnoĭ ékstraktsii, v sravnenii s drugimi stafilokokkovymi preparatami.