Nephrotoxicity following acute administration of N-(3,5-dichlorophenyl)succinimide in rats.
The acute renal effects of the fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) were studied in male Sprague-Dawley rats. NDPS (50 mg/kg, i.p.) increased urine volume and decreased food intake and body weight at 24 h but not 48 h. No change in urine content or the accumulation by renal cortical slices of the organic anion p-aminohippurate (PAH) or the organic cation tetraethylammonium (TEA) was observed with 50 mg/kg NDPS when compared to control animals. Rats receiving 100 or 200 mg/kg NDPS (i.p.) exhibited increased urine volume, proteinuria, glucosuria, decreased food intake and body weight, increased BUN and decreased accumulation of PAH and TEA at both 24 h and 48 h. These effects were generally more pronounced at the 200 mg/kg dose level. Pair-fed control experiments demonstrated that renal effects were NDPS-induced and not related to daily food consumption. NO change in water intake was observed with any dose of NDPS used. The results demonstrate that NDPS alters renal function in a dose-dependent manner. In addition, NDPS (50 mg/kg) is capable of producing diuresis without apparent nephrotoxicity while doses of 100 mg/kg or more produce diuresis and nephrotoxicity.
D000818:Animals; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005659:Fungicides, Industrial / Q000633:toxicity*; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism; D007672:Kidney Cortex / Q000378:metabolism; D007674:Kidney Diseases / Q000139:chemically induced* / Q000652:urine; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013388:Succinimides / Q000633:toxicity*
D005659:Fungicides, Industrial; D013388:Succinimides; C007352:N-(3,5-dichlorophenyl)succinimide