Smoking and circulating IgE in bronchial carcinoma.
The serum concentrations of total IgE were significantly raised in smokers compared to those who had never smoked (p less than 0.005) among male patients with bronchial carcinoma, while no differences were found between smoking and non-smoking female bronchial carcinoma patients. The total IgE levels in male and female patients with non-malignant pulmonary diseases were not correlated to smoking habits. No significant differences in the IgE levels were observed between smoking males subgrouped according to the WHO histological types of bronchial carcinoma. Males with carcinoma who had stopped smoking more than 10 years ago had significantly reduced IgE levels compared to male cancer patients continuously smoking (p less than 0.01). These data, indicating that smoking is associated with elevated IgE levels in males with bronchial carcinoma, might suggest that smoking in certain, preferably male, individuals induces an impaired cellular immunity which is reflected by an enhanced IgE synthesis and a depressed resistance to carcinogens of tobacco smoke.
D000328:Adult; D000368:Aged; D002283:Carcinoma, Bronchogenic / Q000276:immunology*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D008171:Lung Diseases / Q000276:immunology; D008175:Lung Neoplasms / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D012907:Smoking
D007073:Immunoglobulin E