Effects of estrogen administration on serum testosterone in Copenhagen rats.
In order to develop a standard experimental method of exogenous therapy in the Copenhagen rat, several treatment regimens were evaluated to determine their effect on the serum testosterone. Diethylstilbestrol diphosphate (DES-P) was administered either continuously in the drinking water or as a single intraperitoneal injection. Oral low-dose estrogen (0.4-1.6 microgram/ml) yielded reliable suppression of serum testosterone to castrate levels. A single intraperitoneal injection of 0.5 mg DES-P caused prompt suppression of serum testosterone with return to normal levels two weeks later.
D000284:Administration, Oral; D000367:Age Factors; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004054:Diethylstilbestrol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains / Q000097:blood*; D013739:Testosterone / Q000097:blood*
D000970:Antineoplastic Agents; D013739:Testosterone; D004054:Diethylstilbestrol; C004955:fosfestrol