Influence of nonsteroidal anti-inflammatory compounds on healing of chronic gastric ulcers in rats.
Pre-treatment with NOSAC led to an increase of ulcer index in a dose-dependent manner indicating the aggravation of gastric lesions under the influence of NOSAC. The severity of mucosal lesions was diminished by lengthening the time between the last day of pre-treatment with NOSAC and the day on which ulcers were induced. When NOSAC were administered after the induction of gastric ulcers, the healing of the latter was significantly delayed.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002908:Chronic Disease; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000503:physiopathology*
D000893:Anti-Inflammatory Agents