Aromatase in the central nervous system.
Central (central nervous system and pituitary) aromatization appears to be a fundamental process for endocrine control and development. Metabolism of androgens to estrogens and the subsequent metabolism of estrogens have been proven in many species, including humans, and linked to estrogen action. Thus, aromatization appears to initiate or to be involved in activities of importance to endocrine function at the central level and their effects peripherally. In the context of breast cancer, central aromatization relates to the control of gonadotrophins and other pituitary-brain hormones which may effect metabolism at the level of the breast. For example, follicle-stimulating hormone can increase aromatization and may be a factor in the control of such metabolism in breast tissue.
D000728:Androgens / Q000378:metabolism; D000818:Animals; D001141:Aromatase / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism; D002490:Central Nervous System / Q000201:enzymology*; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D010088:Oxidoreductases / Q000378:metabolism*; D011372:Progestins / Q000378:metabolism; D011817:Rabbits
D000728:Androgens; D004967:Estrogens; D011372:Progestins; D010088:Oxidoreductases; D001141:Aromatase