Lack of CCK-like pancreatic stimulation by intraduodenal amino acids in the anesthetized cat.
We have attempted to demonstrate a pancreatic secretory response to intraduodenal amino acids in the anesthetized cat. In four cats stimulated with supramaximal doses of secretin, protein concentrations in pancreatic juice were measured after intraduodenal bolus injection of various amino acids, IV CCK, or electrical stimulation of the vagus nerve. In addition, the duodenum was perfused with phenylalanine (50 mM) for 30 min in two cats, and the vagus nerve stimulated electrically for 15 min in one. In no case did amino acids produce pancreatic protein secretion, whereas CCK and vagal stimulation always did so. We conclude that this insensitivity to amino acids in the cat is a species difference from the dog and man.
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D002766:Cholecystokinin / Q000494:pharmacology*; D004386:Duodenum / Q000294:innervation / Q000502:physiology*; D004558:Electric Stimulation; D010189:Pancreatic Juice / Q000187:drug effects / Q000378:metabolism*; D010649:Phenylalanine / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism; D012633:Secretin / Q000494:pharmacology*; D014364:Tryptophan / Q000494:pharmacology; D014630:Vagus Nerve / Q000502:physiology*
D000596:Amino Acids; D011506:Proteins; D012633:Secretin; D010649:Phenylalanine; D014364:Tryptophan; D002766:Cholecystokinin