Brain cells of the male rhesus monkey accumulate 3H-testosterone or its metabolites.
Autoradiography was used to localize target cells for 3H-testosterone or its labeled metabolites in the brain of the rhesus monkey. Two castrated males were injected intravenously with 3H-testosterone (2 mCi/monkey) and were killed 1 hour later. In both animals, neurons that concentrated radioactivity in their nuclei were located in a well-circumscribed system that included the bed nucleus (n.) of the stria terminalis, medial preoptic n., suprachiasmatic preoptic n., anterior hypothalamic area, ventromedial hypothalamic n., cortical, medial, and basal accessory amygdaloid n., mesencephalic reticular n., and periaqueductal gray matter. In contrast to reports in some nonprimate mammalian species, little or no cellular labeling was observed in the lateral septum, arcuate n.-median eminence, motor nuclei of cranial nerves, or spinal cord.
D000679:Amygdala / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D001931:Brain Mapping; D002369:Castration; D007031:Hypothalamus / Q000378:metabolism; D008253:Macaca mulatta; D008297:Male; D008636:Mesencephalon / Q000378:metabolism; D011301:Preoptic Area / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism*
D013739:Testosterone