Radiation equivalence of genotoxic chemicals. Validation in cultured mammalian cell lines.
Published data on mutations induced by ionizing radiation and 6 monofunctional alkylating agents, namely EMS, MMS, ENNG, MNNG, ENU and MNU, in different cell lines (Chinese hamster ovary, Chinese hamster lung V79, mouse lymphoma L5178 and human cells) were analysed so that radiation-equivalent chemical (REC) values could be calculated. REC values thus obtained for a given alkylating agent with different cell lines fall within a narrow range suggesting its validation in cultured mammalian cell systems including human.
D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007940:Leukemia L5178; D008168:Lung; D051379:Mice; D009153:Mutagens / Q000494:pharmacology*; D010053:Ovary; D011839:Radiation, Ionizing; D014894:Weights and Measures
D000477:Alkylating Agents; D009153:Mutagens