Effect of febantel against Ancylostoma caninum and Trichuris vulpis infections in dogs.
Febantel was administered as a 3.4% paste to 45 dogs infected with 1 or more nematode species, which included Ancylostoma caninum and Trichuris vulpis. Dosage levels of 5, 10, or 15 mg/kg of body weight daily for 3 consecutive days for a total of 15, 30, or 45 mg/kg were administered. At 15 mg/kg, all dogs were completely cleared of all nematode and cestode infections, including A caninum, T vulpis, Uncinaria stenocephala, Toxocara canis, Toxascaris leonina, Taenia sp, and Dipylidium caninum, except for 1 Physaloptera sp adult. The 2 other dosage levels produced somewhat lower efficacy, with the 5 mg/kg being the least effective. The paste appeared palatable to the dogs and there were no apparent adverse effects.
D000724:Ancylostomiasis / Q000188:drug therapy / Q000662:veterinary; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D002590:Cestode Infections / Q000188:drug therapy / Q000662:veterinary; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D006146:Guanidines / Q000008:administration & dosage / Q000627:therapeutic use*; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary; D014257:Trichuriasis / Q000188:drug therapy / Q000662:veterinary
D000871:Anthelmintics; D006146:Guanidines; C017309:febantel