Mechanism of hemolysis by Renalin, a CAMP-like protein from Corynebacterium renale.
Synergistic hemolysis of sheep erythrocytes caused by Staphylococcus aureus and Corynebacterium renale resulted from the combined action of extracellular staphylococcal sphingomyelinase C and a newly described extracellular agent of C. renale (renalin). The affinity of renalin for ceramide was considered to play a key role in causing hemolysis in erythrocytes in which ceramide had been generated through the action of sphingomyelinase C.
D019342:Acetic Acid; D001426:Bacterial Proteins / Q000494:pharmacology*; D002518:Ceramides / Q000378:metabolism; D003352:Corynebacterium; D004338:Drug Combinations; D004910:Erythrocyte Membrane / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects*; D006460:Hemolysin Proteins; D006861:Hydrogen Peroxide; D008970:Molecular Weight; D010463:Peracetic Acid; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism; D013211:Staphylococcus aureus / Q000201:enzymology
D001426:Bacterial Proteins; D002518:Ceramides; D004338:Drug Combinations; D006460:Hemolysin Proteins; C117603:Renalin; D006861:Hydrogen Peroxide; D013108:Sphingomyelin Phosphodiesterase; D010463:Peracetic Acid; D019342:Acetic Acid