A delay in blood clotting of chickens and ducks induced by aflatoxin treatment.
Using the thrombotest technique blood clotting times were measured in the duck and the chicken after an intraperitoneal (I.P.) administration of aflatoxin B1 (58 microgram/kg body weight). Six hours after injection, the average thrombotest (blood clotting) time of the blood of the young duck was 194.5 +/- 1.3 sec (control time was 101.5 +/- 1.4, P less than .0001) and that of the young chicken averaged 70.2 +/- sec (control time was 51.7 +/- 2 sec, P less than .001). Corresponding times for the aflatoxin-treated adult birds were 249.5 +/- 1.4 sec (control, 118.5 +/- 1.1 sec; P less than .001) and 82.9 +/- .2 sec (control, 66.8 +/- .1 sec; P less than .001) for the duck and chicken respectively. In addition to the relatively low concentration of blood clotting factors in the plasma of the bird the present results suggest that there is a weak interaction of blood clotting factors II, VII, IX, and X in the avian species during aflatoxin poisoning. There is an inter-species difference in the anticoagulant effects of aflatoxin in the avian class.
D000348:Aflatoxins / Q000494:pharmacology*; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D002645:Chickens / Q000502:physiology*; D004372:Ducks / Q000502:physiology*; D008297:Male; D011517:Prothrombin Time / Q000662:veterinary
D000348:Aflatoxins