Calcium and phosphate supplements in breast milk-related rickets. Results in a very-low-birth-weight infant.
Rickets developed in a very-low-birth-weight infant fed exclusively human milk. Serum 25-hydroxyvitamin D concentration was normal, and serum 1,25-dihydroxyvitamin D level was elevated; parathyroid hormone and calcitonin levels were normal. Rickets responded to supplements of calcium and phosphate, as determined by roentgenograms and measurement of bone mineral content by direct photon absorptiometry. Human-milk feeding in very-low-birth-weight infants requires observation for hypophosphatemia and clinical and radiological signs of rickets. In such infants, it may be necessary to supplement breast-milk feeding with calcium and phosphate.
D001842:Bone and Bones / Q000032:analysis; D002118:Calcium / Q000172:deficiency; D002136:Calcium, Dietary / Q000627:therapeutic use*; D005260:Female; D005527:Food, Fortified; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008895:Milk, Human; D008903:Minerals / Q000032:analysis; D010710:Phosphates / Q000172:deficiency / Q000627:therapeutic use*; D012279:Rickets / Q000178:diet therapy* / Q000209:etiology
D002136:Calcium, Dietary; D008903:Minerals; D010710:Phosphates; D002118:Calcium