Dominant lethal studies in rats with 1,2-dibromo-3-chloropropane and its structurally related compounds.
Dominant lethal studies were conducted in SD male rats with 5 halogenated 3-carbon compounds that are structurally similar to a known mutagen 1,2-dibromo-3-chloropropane (DBCP). 1,2,3-Tribromopropane induced dominant lethal mutation especially in the early spermatid stage. This finding was almost the same as that obtained after DBCP treatment. The estimated dominant lethal mutation index of a group treated with 1,2-dibromopropane was marginal at week 1 of testing. On the other hand, bromopropane, 1,2,3-trichloropropane and 1-chloropropane produced negative responses for induction of dominant lethals.
D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D005313:Fetal Death; D005799:Genes, Dominant / Q000187:drug effects*; D005804:Genes, Lethal / Q000187:drug effects*; D007306:Insecticides / Q000494:pharmacology*; D008297:Male; D009154:Mutation; D011247:Pregnancy; D011407:Propane / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D007306:Insecticides; C007318:1,2-dibromo-3-chloropropane; D011407:Propane