[Immunologic stimulation with vitamin A in advanced cervix cancer].
For treatment of patients with inoperable cervical cancer (FIGO III) a randomized trial has been initiated. Patients were randomized to receive either conventional irradiation therapy together with vitamin A palmitate (1.5 mill. I.U./day; total dose: 30 mill. I.U.), applied orally, or irradiation alone. When lymphocyte reactivity to PHA (maximum response during therapy) was compared within the groups, it was found, that 66% of the patients who received irradiation combined with vitamin A palmitate, showed an increase in their blastogenic response, while in irradiated patients without vitamin A palmitate a response was seen only in 33%. This difference being statistically significant in comparison to pretreatment values. From immunological data it can be concluded, that vitamin A has an effect on functional response on T-cells. Concerning the clinical outcome, after an observation period of 12 months relapse rates were lower in the vitamin A group, but not significantly reduced. Therefore further follow up is warranted.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007114:Immunization; D008213:Lymphocyte Activation / Q000187:drug effects; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D014801:Vitamin A / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D014801:Vitamin A
Immunstimulation durch Vitamin A beim fortgeschrittenen Gebärmutterhalskarzinom.