Lack of ultraviolet mutagenesis in radiation-resistant bacteria.
Ultraviolet (UV) radiation did not induce rifampicin-resistant mutants in populations of the taxonomically-related radiation-resistant bacteria Deinococcus radiodurans, D. radiopugnans, D. radiophilus and D. proteolyticus, although such mutants arose spontaneously at a low frequency and at a high frequency after treatment of cultures with N-nitroso compounds. The radiation-resistant bacteria Arthrobacter radiotolerans and P-30-A were also UV-immutable whereas the more radiation-sensitive Pseudomonas radiora was UV-mutable. We conclude that the radiation-resistant bacteria repair UV-induced DNA damage accurately and lack an error-prone pathway for the repair of such damage.
D001419:Bacteria / Q000187:drug effects / Q000528:radiation effects*; D004352:Drug Resistance, Microbial; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D009154:Mutation; D009605:Nitrosomethylurethane / Q000494:pharmacology; D011836:Radiation Tolerance; D012293:Rifampin / Q000494:pharmacology; D013045:Species Specificity; D014466:Ultraviolet Rays
D008769:Methylnitronitrosoguanidine; D009605:Nitrosomethylurethane; D012293:Rifampin