[Use of the inhibition of myocardial lipid peroxidation for use therapy and prevention of experimental transitory coronary failure].
This work was done on 116 white random-bred male rats using the experimental model of transient coronary insufficiency of varying duration and showed that activation of free-radical peroxidation of myocardial lipids is one of the main pathogenetic factors in the mechanism of development of the ischaemia and reperfusion damage of the heart in transient coronary insufficiency. Inhibition of lipid peroxidation after preliminary administration to the animals of sodium selenite and myophedrine significantly enhanced the heart's resistance to reversible ischaemia. It is suggested that the use of antioxidants is an effective method of pathogenetic therapy and prevention of transient coronary insufficiency.
D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control; D004353:Drug Evaluation, Preclinical; D008054:Lipid Peroxides / Q000037:antagonists & inhibitors*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D010084:Oxidation-Reduction / Q000187:drug effects; D010099:Oxyfedrine / Q000627:therapeutic use; D051381:Rats; D020887:Selenious Acid; D012643:Selenium / Q000627:therapeutic use
D008054:Lipid Peroxides; D010099:Oxyfedrine; D020887:Selenious Acid; D012643:Selenium
Primenenie ingibirovaniia perekisnogo okisleniia lipidov miokarda dlia terapii i profilaktiki tranzitornoĭ koronarnoĭ nedostatochnosti v éksperimente.