The effect of protamine on proteinuria and glomerular sclerosis in aminonucleoside nephropathy.
An administration of protamine sulfate combined with aminonucleoside of puromycin (AN) could produce in rats severe nephrotic syndrome and histological changes similar to focal glomerular sclerosis more distinctly than AN alone. This may be attributed to the action of protamine which seemed to enhance the effect of AN, causing polyanion loss at the glomerular basement membrane.
D000818:Animals; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009404:Nephrotic Syndrome / Q000139:chemically induced / Q000473:pathology*; D011479:Protamines / Q000494:pharmacology*; D011507:Proteinuria; D011691:Puromycin / Q000031:analogs & derivatives*; D011692:Puromycin Aminonucleoside / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012598:Sclerosis
D011479:Protamines; D011691:Puromycin; D011692:Puromycin Aminonucleoside