[Estriol serum levels following betamethasone treatment for induction of fetal lung maturity (author's transl)].
23 pregnant women with 28 to 37 weeks of gestation, threatened by premature labor, received Betamethasone 8 mg at admission and 4 mg 24 hours later to prevent newborn-RDS. Four women experienced this treatment twice. Blood was sampled for determination of estriol before each administration of Bethametasone and 24 hours after. Group I, patients with no signs of placental insufficiency, showed a drop in estriol levels at the second sample, but these recovered at the third one. There was no recovery seen at the third sample with group III, representing patients with proven placental insufficiency. Patients demonstrating pathologic CTG or delivering babies with low Apgar scores (Group II) showed no consistent course with their estriol levels. The course of estriol after administration of Betamethasone may be used as a test to determine the quality of the feto placental unit.
D001623:Betamethasone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004958:Estradiol / Q000097:blood*; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood / Q000188:drug therapy; D005325:Fetal Organ Maturity / Q000187:drug effects; D005865:Gestational Age; D006801:Humans; D008168:Lung / Q000196:embryology*; D007752:Obstetric Labor, Premature / Q000097:blood; D010927:Placental Insufficiency / Q000097:blood / Q000188:drug therapy; D011247:Pregnancy
D004958:Estradiol; C028994:betamethasone sodium phosphate; D001623:Betamethasone
Serumöstriolspiegel nach Betamethasongabe zur Förderung der Lungenreife.