[Antitumor and toxic properties of retinoid C15].
A study was made of antitumor and toxic properties of retinoid C15 which has some characteristic structural features of retinoic acid natural metabolites; such as ethyl-2E, 4E-3-methyl-5-/2,6-dimethyl-6-ethoxycarbonyl-/3-oxo-1-cyclohexene-1-yl/-2,4-pentadienoate. The substance inhibited the growth of transplantable tumors of the uterine cervix. Lewis carcinoma and rumen cancer. This ability was dependent on the tumor growth rate. The substance proved less toxic then retinoic acid or methyl retionate. Injection of retinoid C15 was accompanied by the widening of the paracortical zone of the mesenterial lymph node and by the increased number of lymphoid follicles in the spleen.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D005260:Female; D007928:Lethal Dose 50; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000188:drug therapy; D013274:Stomach Neoplasms / Q000188:drug therapy; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity
D000970:Antineoplastic Agents; D014801:Vitamin A
Protivoopukholevye i toksicheskie svoĭstva retinoida C15.