Influence of native and randomized peanut oil on lipid metabolism and aortic sudanophilia in the vervet monkey.
Vervet monkeys (Cercopithecus aethiops pygerethrus) were fed cholesterol-free, semipurified diets containing 40% sucrose, 25% casein, 15% cellulose and 14% peanut oil (PNO), randomized peanut oil (RPNO) or corn oil (CO). After 4 months, serum cholesterol and triglyceride levels, serum lecithin-cholesterol acyl transferase (LCAT) activity and plasma lipoprotein lipase (LPL) activity were similar in all groups. Livers of monkeys fed CO converted 156% more acetate and 24% more mevalonate to cholesterol than those of monkeys fed RPNO. Cholesterogenesis in RPNO-fed monkeys was enhanced compared to PNO (68% from acetate; 62% from mevalonate). Incidence of atherosclerosis was 33% in monkeys fed RPNO, 80% in those fed CO and 90% in those fed PNO. Extent of sudanophilia was lowest in aortas of monkeys fed RPNO. Incidence of arteriosclerosis was 40% in monkeys fed CO, 56% in those fed RPNO and 70% in those fed PNO. Extent of aortic surface showing arteriosclerosis was highest in monkeys fed RPNO.
D000818:Animals; D001011:Aorta / Q000032:analysis; D001161:Arteriosclerosis / Q000209:etiology*; D002522:Chlorocebus aethiops; D002784:Cholesterol / Q000096:biosynthesis* / Q000097:blood; D003314:Corn Oil; D004041:Dietary Fats / Q000009:adverse effects*; D050356:Lipid Metabolism; D008099:Liver / Q000032:analysis; D009821:Oils / Q000009:adverse effects*; D000074241:Peanut Oil; D010713:Phosphatidylcholines / Q000097:blood; D010938:Plant Oils; D011897:Random Allocation; D014280:Triglycerides / Q000097:blood
D004041:Dietary Fats; D009821:Oils; D000074241:Peanut Oil; D010713:Phosphatidylcholines; D010938:Plant Oils; D014280:Triglycerides; D003314:Corn Oil; D002784:Cholesterol