Membrane potentials of differentiating enterocytes.
A positional analysis of enterocyte membrane potential has been carried out using in vitro preparations of rabbit distal ileum. Young enterocytes were found to possess a microvillar membrane potential significantly less than that seen in older enterocytes. The length of enterocyte microvilli was also found to be significantly less in younger enterocytes. It is suggested that developmental changes in membrane potential, occurring during the early stages of enterocyte differentiation, probably reflect a changed permeability to ions associated with the establishment of a fully developed microvillar membrane. Other explanations for the observed findings are also considered.
D000367:Age Factors; D000818:Animals; D002454:Cell Differentiation; D046508:Culture Techniques; D007082:Ileum; D007413:Intestinal Mucosa / Q000166:cytology / Q000502:physiology*; D008564:Membrane Potentials; D008871:Microvilli / Q000502:physiology; D011817:Rabbits