Nuclear feulgen DNA content and nuclear size in human breast carcinoma.
Biopsy specimens from 29 patients with operable breast carcinomas were examined by Feulgen-DNA microspectrophotometry. A diploid DNA stemline was found in ten tumors, seven of which were stage I carcinomas. In 19 tumors, ten of which were stage II cancers, a non-diploid DNA stemline was observed. The diploid tumors were most often estrogen receptor-positive (nine of nine examined carcinomas), whereas 13 of 19 non-diploid tumors studied did not contain estrogen receptors. The mean nuclear size of the non-diploid tumor cells was increased compared with that of the diploid malignant cells. Three grade I carcinomas were diploid, whereas three grade III tumors were non-diploid. Of the 23 grade II carcinomas, seven were diploid and 16 non-diploid. Hum Pathol 13:626-630, 1982.
D000232:Adenofibroma / Q000032:analysis* / Q000235:genetics / Q000473:pathology; D001345:Autoradiography; D001943:Breast Neoplasms / Q000032:analysis* / Q000235:genetics / Q000473:pathology; D002467:Cell Nucleus / Q000032:analysis / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis* / Q000235:genetics; D004171:Diploidy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging
D004273:DNA, Neoplasm