[Characteristics of the degree and spectrum of antiviral activity of 2-(1'-aminoethyl)-bicyclo[2.2.1]heptane hydrochloride].
A high activity of a bicycloheptane derivative against influenza viruses, poor activity against Venezuelan equine encephalomyelitis and parainfluenza type 3 viruses, and the lack of activity against herpes simplex, vaccinia, ECHO 6, adenovirus type 3 replicating in tissue cultures were demonstrated. The efficacy of the drug in orthomyxovirus infection of tissue culture includes the viruses with the antigenic formula A (H3N2) and A (H1N1), is poor with the A/PR8/34 (H0N1) virus, and lacking with influenza B virus. The characteristics of antiviral activity of the drug obtained in tissue culture, chick embryos, and white mice were not inferior to that of remantadine. Animal experiments demonstrated its lower toxicity as compared with remantadine allowing it to be used in higher doses, thereby exceeding the effect of remantadine.
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use* / Q000633:toxicity; D002642:Chick Embryo; D004353:Drug Evaluation, Preclinical; D007928:Lethal Dose 50; D051379:Mice; D009636:Norbornanes / Q000627:therapeutic use* / Q000633:toxicity; D009975:Orthomyxoviridae / Q000187:drug effects; D009976:Orthomyxoviridae Infections / Q000188:drug therapy; D012299:Rimantadine / Q000627:therapeutic use / Q000633:toxicity; D014776:Virus Cultivation
D000998:Antiviral Agents; D009636:Norbornanes; D012299:Rimantadine; C034486:2-(1'-aminoethyl)bicyclo(2.2.1)heptane
Kharakteristika stepeni spektra protivovirusnoĭ aktivnosti 2-(1'-aminoétil)-bitsiklo[2.2.1]geptan khlorgidrata.