Clearance and distribution of intratracheally instilled vanadium compounds in the rat.
Intratracheally instilled 48V2O5 was rapidly cleared from the lung into blood, liver and bone. Approx. 40% of the recovered 48V was excreted, primarily in urine by day 3, while the skeleton accounted for 30% by day 7. The behavior of instilled 48VO2Cl was similar to that of 48V2O5. Uptake of gavaged 48V2O5 was 2.6% of administered dose. Skeleton, lung, kidney and liver are primary targets for intratracheally instilled 48V with uptake being much greater via the intratracheal route than by the oral route.
D000818:Animals; D005243:Feces / Q000032:analysis; D005260:Female; D007441:Intubation, Gastrointestinal; D007442:Intubation, Intratracheal; D011868:Radioisotopes; D051381:Rats; D014018:Tissue Distribution; D014639:Vanadium / Q000008:administration & dosage / Q000378:metabolism*
D011868:Radioisotopes; D014639:Vanadium