Synergism between vitamins C and E: effect on microsomal hydroxylation in guinea pig liver.
A separate administration of high doses of L-ascorbic acid or DL-alpha-tocopherylacetate to guinea pigs, fed a cholesterol diet with low content of vitamins C and E enhances the activity of aniline hydroxylase and p-nitro-anisole O-demethylase in hepatal microsomes. A simultaneous administration of the two vitamins exerts a synergic action on aniline hydroxylase. An optimum combination of vitamins C and E may substantially enhance the detoxicating ability of the liver.
D000815:Aniline Hydroxylase / Q000032:analysis; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D004357:Drug Synergism; D006168:Guinea Pigs; D006900:Hydroxylation; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D014810:Vitamin E / Q000494:pharmacology*
D014810:Vitamin E; D000815:Aniline Hydroxylase; D001205:Ascorbic Acid