[Reaction between endogenous opiates and human peripheral blood lymphocytes].
The radioreceptor method and determination of the content of cAMP in lymphocytes were used to study the interplay of met-enkephalin with human peripheral blood lymphocytes. The characteristics of specific binding of endogenous opiate with the cells, as well s a decrease in the activity of lymphocyte adenylate cyclase observed under the effect of met-enkephalin proved the presence of a specific interplay between the physiological concentrations of the opiate with lymphocytes. It is suggested that it is determined by the existence of two parallel mechanisms: a process having some features in common with the receptor binding and limited transport of the opiate inside the cell.
D000067956:Adenylyl Cyclase Inhibitors; D001665:Binding Sites; D004723:Endorphins / Q000378:metabolism*; D004744:Enkephalin, Methionine; D004745:Enkephalins / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000378:metabolism*
D000067956:Adenylyl Cyclase Inhibitors; D004723:Endorphins; D004745:Enkephalins; D004744:Enkephalin, Methionine
Izuchenie vzaimodeĭstviia éndogennykh opiatov s limfotsitami perifericheskoĭ krovi cheloveka.