A comparative study of saliva and serum paracetamol levels using a simple spectrophotometric method.
The relationship between saliva and serum paracetamol levels was investigated in ten healthy male volunteers. The salivary and serum paracetamol levels showed significant correlation with each other. The salivary and serum paracetamol concentration ratio was highly dependent on sampling time. The salivary and serum paracetamol half-lives showed significant correlation with each other while the area under curve of paracetamol concentration in saliva and serum failed to show significant correlation.
D000082:Acetaminophen / Q000097:blood / Q000378:metabolism*; D000328:Adult; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D012463:Saliva / Q000378:metabolism*; D013053:Spectrophotometry / Q000379:methods
D000082:Acetaminophen