Effect of split doses of radiation on mutation frequency in rodent cell lines.
Mutation frequencies in mouse cells and Chinese hamster cells were measured following single or split doses of UV light or X-rays. Split doses separated by a few to over 24 h induced no more ouabain- or 6-thioguanine-resistant mutants than did comparable single doses. These data lend no support to the possible existence of an inducible error-prone repair system in rodent cells.
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects / Q000528:radiation effects; D002460:Cell Line; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D004307:Dose-Response Relationship, Radiation; D005020:Ethyl Methanesulfonate / Q000494:pharmacology; D007700:Kinetics; D008168:Lung; D051379:Mice; D009154:Mutation; D011830:Radiation Effects; D014466:Ultraviolet Rays
D005020:Ethyl Methanesulfonate