Genetic models of schizophrenia.
Multiple threshold models of inheritance are applied to a large sample of Franz Kallmann's (1938) pedigree data on schizophrenia. Paranoid and nonparanoid subtypes are represented in the models at different thresholds on a continuum of genetic-environmental liability. Single major locus and multifactorial-polygenic inheritance are ruled out as modes of transmission. These findings suggest that the paranoid-non-paranoid dichotomy cannot be used as a genetic threshold determinant in the population studied.
D005787:Gene Frequency; D006579:Heterozygote; D006801:Humans; D008957:Models, Genetic; D009679:Nuclear Family; D012306:Risk; D012559:Schizophrenia / Q000235:genetics*; D012563:Schizophrenia, Paranoid / Q000235:genetics