Dermatomyositis and dermatitis herpetiformis.
Primary hypothyroidism, dermatomyositis, dermatitis herpetiformis (DH), and Sjögren's syndrome developed sequentially, over a 20-year period, in a 67-year-old woman. The principal manifestations of her illness were periodic and simultaneous exacerbations of dermatomyositis and DH. Her histocompatability antigens were A1,B8, a haplotype associated with autoimmune diseases. We suggest that this unusual disease complex has a genetic basis.
D000368:Aged; D001327:Autoimmune Diseases / Q000235:genetics; D003874:Dermatitis Herpetiformis / Q000235:genetics* / Q000276:immunology; D003882:Dermatomyositis / Q000235:genetics* / Q000276:immunology; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000235:genetics / Q000276:immunology; D012859:Sjogren's Syndrome / Q000235:genetics / Q000276:immunology