Effects of hydrocortisone acetate on pulmonary alveolar macrophage colony-forming cells.
We investigated the effect of prolonged monocytopenia induced by daily injections of hydrocortisone acetate on the number of alveolar cells and alveolar macrophage colony-forming cells (AL-CFC) in mice. We did not observe an appreciable reduction in the number of either alveolar macrophages of AL-CFC under this experimental condition, which markedly inhibited the blood monocyte concentration over 10 days. These results suggest the existence of a mechanism by which the number of alveolar macrophages, including AL-CFC, can be maintained without a continuous migration of blood monocytes into alveolar spaces.
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001202:Ascitic Fluid / Q000166:cytology; D002452:Cell Count; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000494:pharmacology; D007958:Leukocyte Count; D008264:Macrophages / Q000166:cytology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009000:Monocytes / Q000166:cytology; D011650:Pulmonary Alveoli / Q000166:cytology*; D013864:Thioglycolates / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D013864:Thioglycolates; C021650:hydrocortisone acetate; D006854:Hydrocortisone