Effect of hypoxia on the acute toxicity of acrylonitrile.
The modifying effects of hypoxia (7% 02) on acute lethality; and concentration of tissues non-protein sulfhydryls (NPSH) after acrylonitrile (ACN) exposure were studied. Hypoxia plus ACN exposure in male rats produced a substantial increase in mortality and a greater decrease in NPSH than ACN or hypoxia alone. NPSH in blood did not decrease significantly as a result of hypoxia, ACN or the combination.
D000181:Acrylonitrile / Q000633:toxicity*; D000818:Animals; D001274:Atmospheric Pressure; D000860:Hypoxia / Q000503:physiopathology*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D009570:Nitriles / Q000633:toxicity*; D051381:Rats; D013438:Sulfhydryl Compounds / Q000378:metabolism
D009570:Nitriles; D013438:Sulfhydryl Compounds; D000181:Acrylonitrile