Teratogens associated with congenital contractures in humans and in animals.
An evaluation of over 350 patients in a study of congenital contractures of the joints (arthrogryposis) included a review of family, pregnancy, and delivery histories for teratogenic exposures. Fifteen out of the total 350 patients studied had a possible teratogenic exposure: an infectious agent (viral or bacterial), maternal drug or toxin ingestion, chronic maternal neurologic or muscular illness, or a direct physical insult such as a structural uterine anomaly. Literature was reviewed for all human and animal cases reported with congenital contractures of the joints with an associated teratogenic insult. Those findings are discussed here.
D000818:Animals; D001176:Arthrogryposis / Q000139:chemically induced / Q000209:etiology*; D001424:Bacterial Infections / Q000150:complications*; D000431:Ethanol / Q000633:toxicity; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008721:Methocarbamol / Q000633:toxicity; D009136:Muscular Dystrophies / Q000150:complications; D009157:Myasthenia Gravis / Q000150:complications; D010947:Plants, Toxic; D011247:Pregnancy; D011248:Pregnancy Complications; D013723:Teratogens; D013752:Tetracycline / Q000009:adverse effects; D014777:Virus Diseases / Q000150:complications*
D013723:Teratogens; D008721:Methocarbamol; D000431:Ethanol; D013752:Tetracycline