Enhancement of footshock-induced analgesia by spinal 5,7-dihydroxytryptamine lesions.
The analgesia induced by 30-s footshock (1 mA) is enhanced and attenuated by decreasing and increasing the extraneuronal availability of serotonin (5-HT), respectively. In the present work we have shown the effect to be mediated by spinal 5-HT systems as the response was increased by depletion of spinal but not brain 5-HT following injection of 5,7-dihydroxytryptamine into the spinal cord or raphe magnus. Injection of 5,7-DHT into the medial raphe which depleted brain but not spinal 5-HT was without effect.
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology*; D000698:Analgesia; D000818:Animals; D004102:Dihydroxytryptamines / Q000494:pharmacology*; D004597:Electroshock; D008297:Male; D011903:Raphe Nuclei / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*
D004102:Dihydroxytryptamines; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin