Comparative study of familial polyposis coli and nonpolyposis coli on the histogenesis of large-intestinal adenoma.
The entire length of the large intestine resected from six patients with familial polyposis coli (FPC) was step-sectioned, and microscopic adenomas composed of one to several glands were prepared into complete serial sections. Histopathologic comparison of these microscopic adenomas was made between FPC and nonpolyposis coli (those not included in the special disease group of FPC). The histogenesis of adenomas in FPC and nonpolyposis coli was considered as follows. (1) In nonpolyposis coli, adenomas arise from basal cells of the deep layer of the mucosa. (2) In FPC, most of the adenomas (81.2 per cent) arise in the same manner as described above, although there are some (18.8 per cent) that appear to have arisen in the middle or superficial layer of the mucosa. (3) Therefore, it is believed that the morphologic difference of the large-intestinal mucosa between FPC and nonpolyposis coli comes not from the difference in the number of adenomas present but from the difference in the position and/or timing of appearance of adenomas.
D000236:Adenoma / Q000473:pathology*; D000328:Adult; D003110:Colonic Neoplasms / Q000235:genetics / Q000473:pathology*; D005260:Female; D006801:Humans; D007417:Intestinal Polyps / Q000235:genetics / Q000473:pathology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology*