Subclinical hemolytic disease of the newborn associated with IgG anti-Lub.
An anti-Lub antibody with a titer of 128 to 256 was found in a pregnant woman. The antibody was IgG of the IgG1 subclass. Two newborns of successive pregnancies were free of clinical hemolytic disease of the newborn. The failure of this antibody to cause clinical hemolytic disease is ascribed to the weak expression of the Lub antigen on cord red blood cells.
D000915:Antibody Affinity; D003298:Coombs Test; D004899:Erythroblastosis, Fetal / Q000209:etiology / Q000276:immunology*; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis* / Q000145:classification; D007231:Infant, Newborn; D008188:Lutheran Blood-Group System / Q000276:immunology*; D011247:Pregnancy
D007074:Immunoglobulin G; D008188:Lutheran Blood-Group System