[Reaction of skin and various cell systems after contact with sodium hypochlorite as a model substance (author's transl)].
The efficacy of an externally applied substance is possible by the combination of various experimental methods for investigation of the reaction of the skin and other cell systems. After different contact time of skin or epidermal cells with NaOCl solution under in vivo and in vitro conditions, an influence on the processes of epidermal proliferation, development and differentiation was not provable. On the other hand alterations in other cell systems could be observed. In lymphocytes the content of incorporated 3H-thymidine after in vitro cultivation remained unchanged, however, the possibility of stimulation with PHA was decreased. After external skin contact a comparative analysis of different metabolic processes for interpretation of substance efficacy is necessary.
D000818:Animals; D001345:Autoradiography; D002478:Cells, Cultured; D006224:Cricetinae; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D012867:Skin / Q000187:drug effects*; D012973:Sodium Hypochlorite / Q000494:pharmacology*
D012973:Sodium Hypochlorite
Untersuchungen zur Wirkung von Natriumhypochlorit als Modellsubstanz auf die Haut und verschiedene Zellsysteme.