The effect of sodium on depolarization-induced calcium uptake and acetylcholine release by synaptosomes.
The influence of external sodium concentration on potassium (depolarizing agent)-stimulated calcium uptake and Ca+-dependent acetylcholine release by rat cerebral cortex synaptosomes has been studied. It was found that increased sodium concentration decreased both the Ca2+ uptake and the acetylcholine release, whereas a low external sodium concentration is stimulatory.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D007700:Kinetics; D051381:Rats; D012964:Sodium / Q000494:pharmacology*; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
D012964:Sodium; D000109:Acetylcholine; D002118:Calcium