[Lack of reductase as cause of andrological disturbance?].
We studied steroid metabolites of 35 men with oligoasthenoteratozoospermia. We found a significant decrease of androsterone (p less than 0,01) in urine. The quotient of aetiocholanolone: androsterone was significantly increased (p less than 0,01). This means that there might be a lack of 5 alpha-reductase function. Patients with E: A higher than 3,0 showed a significant side-difference of testis volume compared with the control group (p less than 0,01). We suppose that lack of 5 alpha-reductase induces dissociation of the development of the testis.
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000172:deficiency*; D000328:Adult; D000738:Androsterone / Q000652:urine*; D005043:Etiocholanolone; D006801:Humans; D007248:Infertility, Male / Q000209:etiology* / Q000473:pathology / Q000652:urine; D008297:Male; D009845:Oligospermia / Q000652:urine; D010088:Oxidoreductases / Q000172:deficiency*; D013094:Spermatozoa / Q000473:pathology; D013737:Testis / Q000473:pathology
D005043:Etiocholanolone; D000738:Androsterone; D010088:Oxidoreductases; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase
Reduktaseschwäche als Ursache andrologischer Störungen?