Inducing effect of clofibrate on alkaline phosphatase and histidine-glyoxylate aminotransferase in rat liver.
The activity of plasma membrane alkaline phosphatase and both mitochondrial and peroxisomal histidine-glyoxylate aminotransferase was significantly increased in the livers of male rats following treatment with the hypolipidemic drug clofibrate. Cycloheximide or puromycin administration to rats inhibited the effects of clofibrate.
D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D002994:Clofibrate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D000637:Transaminases / Q000378:metabolism*
D000637:Transaminases; C034736:histidine-glyoxylate aminotransferase; D000469:Alkaline Phosphatase; D002994:Clofibrate