Neuromuscular blocking activity in an extract from the East African wild sisal Sansevieria ehrenbergii.
S. ehrenbergii and A. sisalana extracts (equivalent to 50-250 mg leaf/ml) cause potentiation (ca. 40%) of indirectly elicited contractions of the chick biventer nerve-muscle preparation. The subsequent blockade to direct and indirect stimulation and the sustained but reversible change in baseline tension resemble actions of the depolarizing suxamethonium rather than the nondepolarizing gallamine.
D000818:Animals; D002645:Chickens; D004558:Electric Stimulation; D005703:Gallamine Triethiodide / Q000494:pharmacology; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects; D009466:Neuromuscular Blocking Agents; D010936:Plant Extracts / Q000494:pharmacology*; D013390:Succinylcholine / Q000494:pharmacology
D009466:Neuromuscular Blocking Agents; D010936:Plant Extracts; D013390:Succinylcholine; D005703:Gallamine Triethiodide