[Lichen myxedematosus and scleromyxedema].
Review of the clinical picture, dynamics of the disease, associated symptoms and signs, etiopathology as well as treatment and prognosis of lichen myxedematosus and scleromyxedema. Diagnostic criteria are wax-like papules and leather-like skin thickening, an increase in concentration of acid mucopolysaccharides consisting mainly of hyaluronic acid in the dermis, lympho-plasmacytoid infiltrates in the skin and the bone marrow, normal thyroid function, and paraproteinemia of light chain type lambda or kappa. The nosologic connection of both manifestations implying a single disease entity is emphasized by two of our clinical observations of the transition of lichen myxedematosus to scleromyxedema. An attempt will be made to interpret this as a certain kind of myelomesenchymal syndrome.
D003520:Cyclophosphamide / Q000627:therapeutic use; D006801:Humans; D008010:Lichen Planus / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D009077:Mucins; D009230:Myxedema / Q000175:diagnosis* / Q000473:pathology; D012594:Scleroderma, Localized / Q000175:diagnosis* / Q000473:pathology; D012867:Skin / Q000473:pathology
D009077:Mucins; D003520:Cyclophosphamide; D008727:Methotrexate
Lichen myxoedematosus und Skleromyxödem.