A heat-labile necrotic activity in supernatants from cultures of Legionella pneumophila.
Crude, concentrated extra-cellular supernatants from Legionella pneumophila produced a soft-tissue necrosis, demonstrated by intraperitoneal or sub-cutaneous injections into infant mice. The reaction was rapid and gave a hemorrhagic tissue necrosis within minutes. Being heat-labile, this tissue reaction is different from those of a heat-stable cytotoxin and a heat-stable hemolysin previously described.
D000818:Animals; D001427:Bacterial Toxins / Q000633:toxicity*; D006470:Hemorrhage / Q000139:chemically induced; D006358:Hot Temperature; D007875:Legionella / Q000032:analysis*; D051379:Mice; D009336:Necrosis / Q000139:chemically induced*; D011480:Protease Inhibitors / Q000494:pharmacology
D001427:Bacterial Toxins; D011480:Protease Inhibitors