Benoxaprofen kinetics in renal impairment.
To establish therapeutic guidelines, benoxaprofen kinetics were examined in 26 adult subjects with normal and decreased renal function. Mean peak plasma concentrations after a single 600-mg dose ranged from 58 to 72 mg/l, independent of renal function. Elimination half-life and benoxaprofen plasma clearance correlated with creatinine clearance. Hemodialysis did not remove benoxaprofen from plasma. A dosage nomogram was derived from which a dose one half of the normal maintenance dose was suggested for patients with severe renal failure.
D000328:Adult; D000368:Aged; D005965:Glucuronates / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D007700:Kinetics; D008875:Middle Aged; D011422:Propionates / Q000008:administration & dosage / Q000378:metabolism*; D006435:Renal Dialysis
D005965:Glucuronates; D011422:Propionates; C011677:benoxaprofen