Normal hepatic vitamin-D metabolism in icteric primary biliary cirrhosis associated with pronounced vitamin-D deficiency symptoms.
The intestinal absorption and hepatic metabolism of vitamin D were studied in a woman with icteric primary biliary cirrhosis (PBC) complicated by pronounced bone pain and muscle weakness due to vitamin-D deficiency. The patient had a markedly reduced intestinal absorption of vitamin D, while the 25-hydroxylation of this vitamin was found to be normal despite the presence of longstanding icterus. The malabsorption of fat-soluble compounds secondary to the cholestasis was probably further impaired by several years of cholestyramine treatment. Administration of 1.25-(OH)2D3 increased intestinal calcium absorption, normalized serum calcium and increased bone mineral content of the proximal tibia. Furthermore, drastic improvement of muscle weakness and relief of bone pain were observed. It is recommended that repeated measurements of serum 25-(OH)D should be carried out in patients with PBC, and especially in those treated with cholestyramine. In certain vitamin D deficient patients, studies using radio-labelled vitamin D may provide clinically valuable information as to the exact site of the underlying disturbances.
D002792:Cholestyramine Resin / Q000009:adverse effects; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008099:Liver / Q000378:metabolism*; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D008875:Middle Aged; D010018:Osteomalacia / Q000209:etiology; D014807:Vitamin D / Q000378:metabolism / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism
D002792:Cholestyramine Resin; D014807:Vitamin D