Chronic active hepatitis in Doberman pinschers.
Eleven Doberman Pinschers were affected with a disease that had clinical signs, serum biochemical abnormalities, and histologic features of chronic active hepatitis. Intrahepatic cholestasis and accumulations excess hepatic copper were prominent features. Most of the dogs deteriorated within weeks to months, and 6 died within 9 months after the 1st signs of disease were noticed.
D000818:Animals; D001706:Biopsy / Q000662:veterinary; D002780:Cholestasis, Intrahepatic / Q000209:etiology / Q000662:veterinary; D002908:Chronic Disease; D004283:Dog Diseases / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D004285:Dogs; D005260:Female; D006520:Hepatitis, Animal / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008297:Male; D010396:Penicillamine / Q000627:therapeutic use; D011379:Prognosis
D010396:Penicillamine