Behavioral effects of systemic injection of ibotenic acid manifested without neuromorphological correlates.
Behavioral and neuromorphological effects of intraperitoneally injected ibotenic acid (IBO) were investigated in rats. These injections led to a number of marked behavioral disturbances which ultimately resulted in the death of 6 of the 13 IBO-treated rats. Despite marked changes in behavior, no morphological changes could be detected in the brain tissue of the surviving rats.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D007051:Ibotenic Acid / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000187:drug effects
D010080:Oxazoles; D007051:Ibotenic Acid