[Effect of hyperbaric oxygenation on homocarnosine metabolism in the brains of rabbits of different ages].
Content of homocarnosine and activity of homocarnosine-carnosine synthetase were studied in brain tissue of 1, 7, 14, 21 and 30 days old rabbits under normal state and after treatment with 0.425 mPu of oxygen within 1 hr. The most distinct alterations in the homocarnosine content and the enzymatic activity were observed in rabbit brain at the first month of postnatal life and accompanied development of sight. After hyperbarooxygenation the content of homocarnosine of rabbit brain was decreased in all the age groups studied but, especially (by 60% and 85%, respectively) in brain of 21- and 30 days old animals; the most distinct inhibition (by 71.5%, 81.1% and 92.4%) of homocarnosine-carnosine synthetase activity was observed in brain of 1, 14 and 30 days old rabbits.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D002336:Carnosine / Q000031:analogs & derivatives / Q000378:metabolism*; D004151:Dipeptides / Q000378:metabolism*; D006931:Hyperbaric Oxygenation; D010100:Oxygen; D010313:Partial Pressure; D010453:Peptide Synthases / Q000378:metabolism*; D011817:Rabbits
D004151:Dipeptides; C005038:homocarnosine; D002336:Carnosine; D010453:Peptide Synthases; C019844:carnosine synthetase; D010100:Oxygen
Vliianie giperbaricheskoi oksigenatsii na obmen gomokarnozina v mozge krolikov raznogo vozrasta.