[On the significance of alcoholism for etiology, course and prognosis of cancer of the mouth and oropharynx (author's transl)].
Reviewing the records of 131 patients with malign tumors of the mouth and oropharynx 36 (35%) alcoholics were found among 103 male patients with carcinoma. The highest incidence of alcoholism (58%) was seen in patients with carcinoma of the floor of the mouth. In alcoholics the age distribution showed a peak in the 4th decennium, whereas non-alcoholics had this peak in the 6th decennium. With 64% T3-tumors the alcoholics revealed on an average markedly more advanced tumor stages before treatment than the other patient group with only 29% T3-tumors; metastases in the regional lymphnodes were seen in 50% of the latter, but in 72% of the alcoholics. Skin reaction to radiation therapy appeared particulary pronounced more often in alcoholics (87%) than in the other patients (63%). The 3-year survival rates were 38.5% (alcoholics) and 44.5% (non-alcoholics). These observations suggest that alcoholism with its numerous accompaniments does not only play a role in etiology, but does also have unfavourable effects on the course and the prognosis of cancer of the mouth and oropharynx.
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000209:etiology* / Q000401:mortality; D010610:Pharyngeal Neoplasms / Q000209:etiology*
Zur Bedeutung des Alkoholabusus für Atiologie, Verlauf und Prognose von malignen Mundschleimhaut- und Oropharynxtumoren.