[Calcium transport in the erythrocytes of rats with spontaneous hypertension: characteristics of the effect of calmodulin].
Transport features of calcium in red cells of rats with spontaneous genetic hypertension (SHR) have been studied. It is shown that in the presence of calmodulin the rate of calcium accumulation by the inside-out vesicles of SHR red cell membranes is roughly twice less than in the control normotensive rats. It is suggested that upset interrelationship between calmodulin and Mg-Ca-ATPase of plasma membrane may be the cause of increase of intracellular calcium recorded in a number of tissues in primary hypertension.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000097:blood*; D002135:Calcium-Binding Proteins / Q000627:therapeutic use*; D002147:Calmodulin / Q000627:therapeutic use*; D002463:Cell Membrane Permeability / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004910:Erythrocyte Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002135:Calcium-Binding Proteins; D002147:Calmodulin; D002118:Calcium
Transport kal-tsiia v éritrotsitakh krys so spontannoĭ gipertenzieĭ: osobennosti vliianiia kal'modulina.