A comparison of the metabolism and elimination of benzanilide and salicylanilide in the rat.
1. The metabolism and elimination of benzanilide and salicylanilide in rats were compared. 2. For both compounds, greater than 70% dose was excreted in urine with 20% in faeces, in 3 days. 3. With [14C]benzanilide and [14C]salicylanilide, 40% and 35% respectively of the 14C was excreted in the bile in 24 h. 4. Benzanilide was metabolized to 4'-hydroxybenzanilide (24%), 2-hydroxybenzanilide (salicylanilide, 19%) and 2'-hydroxybenzanilide (13%), with small amounts of 4-hydroxybenzanilide. 5. Salicylanilide was excreted unchanged (56%) with small amounts of the 5-hydroxy and 4'-hydroxy-derivatives. 6. All metabolites were present as glucuronide conjugates; the free aglycones were not found.
D000813:Anilides / Q000378:metabolism*; D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D002250:Carbon Radioisotopes; D005243:Feces / Q000032:analysis; D007700:Kinetics; D008297:Male; D051381:Rats; D012457:Salicylamides / Q000378:metabolism*; D012458:Salicylanilides / Q000378:metabolism*
D000813:Anilides; D002250:Carbon Radioisotopes; D012457:Salicylamides; D012458:Salicylanilides; C034595:benzanilide; C034596:salicylanilide