Lack of effect of 6-hydroxydopamine pretreatment on depolarization-induced release of ATP fron rat brain synaptosomes.
Pretreatment of rats with intraventricular 6-hydroxydopamine produced considerable destruction of noradrenergic and dopaminergic nerve terminals as indicated by depletions in synaptosomal catecholamine contents. However, 6-hydroxydopamine pretreatment did not result in diminished release of ATP during depolarization of synaptosomes with either elevated extracellular K+ or veratridine. These findings suggest that most of the ATP released during the depolarization of rat brain synaptosomal preparations is not co-released with noradrenaline or dopamine but must originate from other sources.
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000032:analysis; D006892:Hydroxydopamines / Q000494:pharmacology*; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism*
D006892:Hydroxydopamines; D000255:Adenosine Triphosphate; D004298:Dopamine