Response of rat brain to calcitonin alteration.
Endogenous calcitonin was altered in rats by thyroparathyroidectomy, followed by supplementation with thyroxine and calcium. As a result, a reduction in the content of 5-hydroxytryptamine in the brain together with an increase in the concentration of tryptophan in the plasma were observed. The changes were accompanied by a diminution in the activity of both choline acetyltransferase and acetylcholinesterase in the cerebral hemispheres. The results are consistent with those produced by exogenous hormone and suggest that calcitonin probably plays a role in the regulation of 5-hydroxytryptamine levels in the brain.
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002116:Calcitonin / Q000097:blood*; D002118:Calcium / Q000097:blood; D002531:Cerebellum / Q000201:enzymology; D002540:Cerebral Cortex / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D014364:Tryptophan / Q000097:blood
D012701:Serotonin; D014364:Tryptophan; D002116:Calcitonin; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase; D002118:Calcium