[Synthesis and tests of antibacterial activity of new analogs of d(+)-threo-1-(p-methylsulphonylphenyl)-2-dichloroacetamido-1,3-propanediol (thiamphenicol)].
The synthesis of three new analogues of D(+)-threo-1-(p.methylsulphonylphenyl)-2-dichloroacetamido-1,3-propanediol (thiamphenicol) (I) which are D(--)-threo-2-(p.toluensulfophonamido)-1-(p.methylsulphonylphenyl)-1,3-propanediol (II), D(--)-threo-2-(p.aminobenzensulphonamido)-1-(p.methylsulphonylphenyl)-1,3-propanediol (III), D(--)-threo-2-(p.acetamidobenzensulphonamido)-1-(p.methylsulphonylphenyl)-1,3-propandiol (IV) is reported. The antibacterial activity of the compounds obtained was estimated in comparison with (I) in vitro and the therapeutic activity in vivo by experimental infection of the rat. The results showed the total absence of both types of activity.
D000818:Animals; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D051379:Mice; D051381:Rats; D013839:Thiamphenicol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D013839:Thiamphenicol
Sintesi ed indagini sulla attività antibatterica di nuovi analoghi del D(+)-treo-1-(p.metilsolfonilfenil)-2-dicloroacetamido-1,3-propandiolo (tiamfenicolo).