Impaired acetaldehyde oxidation in alcoholics.
High blood acetaldehyde levels in alcoholics after ethanol ingestion are due to reduced acetaldehyde oxidation rather than to an increased rate of its formation from ethanol. This is associated with low hepatic acetaldehyde dehydrogenase activity in alcoholic subjects and may represent a specific abnormality in them.
D000079:Acetaldehyde / Q000097:blood*; D000328:Adult; D000437:Alcoholism / Q000097:blood / Q000201:enzymology / Q000378:metabolism*; D000445:Aldehyde Oxidoreductases / Q000378:metabolism*; D000431:Ethanol / Q000097:blood; D006801:Humans; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D011773:Pyruvates / Q000097:blood; D019289:Pyruvic Acid
D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D000431:Ethanol; D019289:Pyruvic Acid; D000445:Aldehyde Oxidoreductases; C018699:aldehyde dehydrogenase (NAD(P)+); D000079:Acetaldehyde