Radiosensitivity of Nall human melanoma transplanted into nude mice: repair, reoxygenation and dose fractionation.
Split and fractionated gamma-rays experimental have been performed on a human melanoma transplanted into nude mice using an in vitro colony assay. Repair of potentially lethal observed after a single dose of 20 Gy was found to no longer occur when 7 daily doses of 2.5 Gy were administered. In split-dose experiments, the increase in survival level probably can not be explained by repair of sublethal damage. When a single high dose of radiation is administered a certain reoxygenation is observed; however there is no reoxygenation when low radiation doses are delivered daily.
D000693:Anaerobiosis; D000818:Animals; D002460:Cell Line; D006801:Humans; D008545:Melanoma / Q000532:radiotherapy*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000532:radiotherapy; D010101:Oxygen Consumption; D011879:Radiotherapy Dosage; D014183:Transplantation, Heterologous