[Experimental model with the additional source of endogenous serotonin].
The only experimental approach to the increase in the body serotonin level is a pharmacological one that has a number of shortcomings. The authors suggest an experimental model with additional source of endogenous serotonin (ASS-model) which occurs after embryonal gastrointestinal tract transplantation beneath the skin of adult syngeneic mice. The developing transplants showed significant amounts of serotonin and serotonin-producing enterochromaffin cells. The ASS-model provides long-term and selective increase in the blood serotonin content (by 40% on the average) with no changes being detected in the brain. This model may be used for studies on the role of serotonin in peripheral regulation of the physiological systems.
D000818:Animals; D001812:Blood-Brain Barrier; D001933:Brain Stem / Q000032:analysis; D002838:Chromaffin System / Q000637:transplantation*; D004759:Enterochromaffin Cells / Q000378:metabolism / Q000637:transplantation*; D005260:Female; D007421:Intestine, Small / Q000637:transplantation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008954:Models, Biological; D011247:Pregnancy; D012701:Serotonin / Q000032:analysis / Q000096:biosynthesis* / Q000097:blood; D013270:Stomach / Q000032:analysis / Q000637:transplantation
D012701:Serotonin
Eksperimental'naia model's dopolnitel'nym istochnikom éndogennogo serotonina.