A model of focal cortical contusion in gerbils.
An experimental model of focal laceration and contusion in gerbils is described. Associated with this injury are systemic changes which are neurogenically mediated and result in an immediate reduction in blood pressure, bradycardia, and generalized reduction in cerebral blood flow. There is generalized edema, as judged by a decreased specific gravity in the brain, probably related to reduced blood flow; superimposed on this, there is an edema gradient which is maximal close to the injury. This, in turn, affects the local capillary bed and prevents any local increase in flow. A separate group studied over a longer time period (6 hours) did not reveal egress of Evans blue into the surrounding tissue and this is in contrast to reports from cold-injury studies.
D000818:Animals; D001924:Brain Concussion / Q000150:complications / Q000503:physiopathology*; D001929:Brain Edema / Q000209:etiology; D002560:Cerebrovascular Circulation; D004195:Disease Models, Animal; D005849:Gerbillinae; D006439:Hemodynamics; D008297:Male; D013046:Specific Gravity