[Clinical picture, diagnosis and therapy of xerostomia--attempt of a survey under pathophysiological aspects (author's transl)].
Xerostomia is a symptom rooted in many causes. Considering the physiology of salivary secretion and its various mechanisms, a systematical classification of these causes can be given. Disorders in reflex evocation and transmission, disorders in the innervation of the salivary glands, in the production and transport of saliva as well as excessive depletion of saliva may lead to xerostomia. Chronic dryness of the mouth can in most instances be attributed today to disturbed innervation of the salivary glands (antidepressive and antihypertensive drugs) and to diseases of the salivary glands (Sjögren syndrome, irradiation). Depending on duration and extent of salivary deficiency, severe changes of the oral mucosa and teeth will develop. Treatment of xerostomia may be performed causally (withdrawal or exchange of drugs inhibiting salivary secretion) but will often only be possible as a symptomatic therapy. For this purpose there are available today saliva surrogate solutions ('artificial saliva') and substances that stimulate the secretion of the still intact salivary gland parenchyma.
D000328:Adult; D000781:Anethole Trithione / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000009:adverse effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects; D012469:Salivary Glands / Q000503:physiopathology; D012859:Sjogren's Syndrome / Q000150:complications; D014987:Xerostomia / Q000139:chemically induced / Q000209:etiology / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy
D000959:Antihypertensive Agents; D000781:Anethole Trithione
Klinik, Diagnostik und Therapie der Xerostomie. Versuch einer Betrachtung unter pathophysiologischen Gesichtspunkten.