[Reproduction study on netilmicin. (3) Perinatal and postnatal study in rats (author's transl)].
Perinatal and postnatal study on netilmicin (NTL), a new aminoglycoside antibiotic, was carried out in Sprague-Dawley rats (Slc : SD). NTL was administered intramuscularly from day 17 of gestation throughout day 20 after delivery at the daily dose of 12.5, 25, 50 and 100 mg/kg. Water intake of pregnant and nursing dams was increased in the animals treated with 50 mg/kg or more of NTL. The increase of cecum weight was observed in F1 animals in all treated groups at 3 weeks of age. However, birth rate, suckling rate, weanling rate, body weight, postnatal development, behavior and reproductive function remained within normal ranges in all treated groups.
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000502:physiology*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D005333:Fetus / Q000187:drug effects; D005839:Gentamicins / Q000633:toxicity*; D007273:Injections, Intramuscular; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007774:Lactation / Q000187:drug effects; D008297:Male; D008431:Maternal-Fetal Exchange; D009428:Netilmicin / Q000008:administration & dosage / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012726:Sexual Behavior, Animal / Q000187:drug effects
D005839:Gentamicins; D009428:Netilmicin