Activity of adenylate deaminase and glutamate dehydrogenase in the liver: species and dietary variation.
1. Activity of glutamate dehydrogenase and adenylate deaminase were measured in the livers of carnivores (animals characterised by intake of a high dietary protein). 2. Animals studied (ferret, cat, dog, hedgehog, rat, hamster, mouse, cow, pig and rabbit) were kept on their natural diet. 3. Glutamate dehydrogenase activity showed no variation between carnivores and non-carnivores. 4. Adenylate deaminase activity was significantly higher in carnivores than in non-carnivores. 5. In carnivores, adenylate deaminase might be the rate limiting enzyme in the terminal deamination of L-amino acids. 6. Elevation of adenylate deaminase might be due to the acidogenic effect of the diet.
D000659:AMP Deaminase / Q000378:metabolism*; D000818:Animals; D002415:Cats; D002417:Cattle; D006224:Cricetinae; D004032:Diet; D004285:Dogs; D005289:Ferrets; D005969:Glutamate Dehydrogenase / Q000378:metabolism*; D006364:Hedgehogs; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D051379:Mice; D009709:Nucleotide Deaminases / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013552:Swine
D005969:Glutamate Dehydrogenase; D009709:Nucleotide Deaminases; D000659:AMP Deaminase