Effect of squalane on hexachlorobenzene (HCB) concentrations in tissues of mice.
Female mice were given 100 mg HCB/kg body weight i.p. and fed diets containing 0, 2.5, 5.0, and 7.5% of squalane. After 3 weeks samples of liver, blood and abdominal fat were analysed for HCB as well as for squalane. HCB concentrations were significantly lowered as compared to controls in all tissues and at all dietary concentrations of squalane to a maximum of about 36% in fat, 44% in liver and 47% in blood. The effect of squalane upon HCB concentrations was strongly dose dependent in abdominal fat. In contrast, no significant differences were seen with liver and blood between animals fed 5.0 or 7.5% of squalane. Squalane was detected in considerable amounts in the livers (50-100 ppm) but not in abdominal fat (less than 1 ppm) of mice fed squalane.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002722:Chlorobenzenes / Q000378:metabolism*; D002849:Chromatography, Gas; D004032:Diet; D004347:Drug Interactions; D005260:Female; D006581:Hexachlorobenzene / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D013185:Squalene / Q000031:analogs & derivatives* / Q000494:pharmacology; D014018:Tissue Distribution
D002722:Chlorobenzenes; D006581:Hexachlorobenzene; D013185:Squalene; C019556:squalane