Postnatal changes in [3H]fucosyl glycopeptides of hamster optic nerve synaptosomal membrane.
Axonally transported glycopeptides of the optic nerve synaptosomal membrane were labeled in neonatal and adult hamsters by intraocular injection of [3H]fucose. A prominent polypeptide in the 50,000 molecular weight region was heavily labeled after eye-opening in 16-day-old and adult hamsters, but not in 5- or 12-day-olds. The data suggest that either synthesis or fucosylation of a major synaptosomal membrane glycopeptide is under developmental control and expressed primarily after the eye-lids open.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D006224:Cricetinae; D005643:Fucose / Q000378:metabolism*; D006020:Glycopeptides / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism*; D007425:Intracellular Membranes / Q000378:metabolism*; D008970:Molecular Weight; D009900:Optic Nerve / Q000254:growth & development* / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism*
D006020:Glycopeptides; D006023:Glycoproteins; D005643:Fucose