Q fever hepatitis: clinical manifestations and pathological findings.
This report describes  the clinical manifestations and pathological findings in 5 patients with serologically diagnosed acute Q fever. Each patient presented with headache, malaise, spiking fever, and hepatitis. Percutaneous biopsy of the liver in 4 patients revealed granulomatous changes with many lesions containing a dense fibrin ring surrounding a central lipid vacuole. Biopsy of the bone marrow in the fifth patient revealed similar abnormalities. These lipogranulomas should be considered characteristic of Q fever.
D000328:Adult; D001706:Biopsy; D001799:Blood Sedimentation; D001831:Body Temperature; D001853:Bone Marrow / Q000473:pathology; D006099:Granuloma / Q000473:pathology; D006505:Hepatitis / Q000097:blood / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011778:Q Fever / Q000097:blood / Q000473:pathology*