Behavioral effects of prenatal exposure to nicotine in guinea pigs.
Nicotine (3 mg/kg SC) administered twice daily throughout pregnancy to guinea pigs resulted in offspring that were behaviorally deficient both as neonates and adults. The nicotine-treated offspring showed reduced spontaneous alternation both as neonates and adults. Also, the nicotine-treated offspring were less likely to enter a novel alley as neonates and were deficient on brightness discrimination and reversal as adults.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D004193:Discrimination Learning / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D005865:Gestational Age; D006168:Guinea Pigs; D008297:Male; D008431:Maternal-Fetal Exchange; D009538:Nicotine / Q000494:pharmacology*; D011247:Pregnancy; D012193:Reversal Learning / Q000187:drug effects
D009538:Nicotine