Effects of intravenous indoprofen on bleeding time and other haemostatic parameters.
The influence of i.v. administration of indoprofen on template bleeding time and other haemostatic parameters was investigated in ten elderly subjects with osteoarthritis. The drug was given first as a single dose (400 mg bolus) and then, after an appropriate interval, as a short-term treatment (200 mg bolus t.i.d. for 7 days). Platelet count, prothrombin time and partial thromboplastin time were never affected, whereas a significant, though moderate, lengthening of bleeding time and a parallel reduction of platelet aggregation were observed in both trials. In the acute one these changes were seen at the first hour following administration and waned in all patients within 96 hours. In the subacute test the bleeding time was steadily prolonged throughout the week of treatment, being slightly still above the baseline value 7 days later, at which time no residual effects were noticeable in platelet aggregation.
D000368:Aged; D001760:Bleeding Time; D001777:Blood Coagulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D007216:Indoprofen / Q000009:adverse effects* / Q000627:therapeutic use; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy; D010666:Phenylpropionates / Q000009:adverse effects*; D010974:Platelet Aggregation / Q000187:drug effects
D010666:Phenylpropionates; D007216:Indoprofen