[Functional importance of catecholamine metabolism in the regulation of AMP-aminohydrolase activity in mitochondria of the heart and other organs].
The paper deals with main pathways for conversion of catecholamines and their effect on the activity of AMP-aminohydrolase in mitochondria of the heart, liver, brain, kidneys and blood serum. Dopamine-beta hydroxylase is stated to participate in manifestation of dopamine effect on the heart AMP-aminohydrolase, the same may be said with respect to monoaminooxidase in realization of the norepinephrine action on the brain AMP-aminohydrolase. Adrenoxyl (stabilized adrenochrome) duplicates the catecholamine effect with respect to AMP-aminohydrolase in certain organs. A three-hour electric stimulation of the aorta arc is accompanied by activation of AMP-aminohydrolase in the heart and blood serum, which is, probably, associated with changes in the balance and metabolism of tissue catecholamines. Data of the AMP-aminohydrolase activity determination may be applied for testing the myocardium damage. AMP-aminohydrolase is discussed for its role in realization of the adrenochrome effect on the myocardium adenylate cyclase.
D000659:AMP Deaminase / Q000378:metabolism*; D000818:Animals; D001011:Aorta / Q000502:physiology; D001921:Brain / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism*; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D004558:Electric Stimulation; D006321:Heart / Q000502:physiology; D007668:Kidney / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism*; D009709:Nucleotide Deaminases / Q000378:metabolism*; D051381:Rats
D002395:Catecholamines; D004299:Dopamine beta-Hydroxylase; D009709:Nucleotide Deaminases; D000659:AMP Deaminase
Funktsional'noe znachenie obmena katekholaminov v reguliatsii aktivnosti AMP-aminogidrolazy v mitokhondriiakh serdtsa i drugikh organov.