Ketamine and e.e.g. seizure waves: interaction with anti-epileptic drugs.
When unrestrained cats were with ketamine 2-6 mg kg-1 i.v., anaesthesia was associated with seizure waves induced in the cortical e.e.g. After cats were pretreated with trimethadione 500 mg kg-1 i.p., ketamine did not induce seizure waves. Pretreatment with diphenylhydantoin 25 or 100 mg kg-1 i.p. slightly enhanced seizure waves following ketamine. In both situations the anaesthetic effect of ketamine remained unaffected.
D000771:Anesthesia, Intravenous; D000818:Animals; D002415:Cats; D004347:Drug Interactions; D004569:Electroencephalography; D005074:Evoked Potentials, Visual / Q000187:drug effects; D007649:Ketamine / Q000494:pharmacology*; D010672:Phenytoin / Q000494:pharmacology; D013997:Time Factors; D014293:Trimethadione / Q000494:pharmacology; D014793:Visual Cortex / Q000187:drug effects*
D010672:Phenytoin; D007649:Ketamine; D014293:Trimethadione