Erythropoietin formation during hypoxia in mice with impaired responsiveness to erythropoietin induced by irradiation or 5-fluorouracil injection.
Plasma erythropoietin levels during continuous exposure to hypobaric hypoxia in mice with marrow aplasia induced by whole body X-irradiation of 5-fluorouracil injection were higher than in control mice similarly exposed. There findings give support to the hypothesis that a relationship exists between erythropoietin production rate and erythroid responsiveness to the hormone.
D000818:Animals; D004912:Erythrocytes / Q000378:metabolism; D004920:Erythropoiesis / Q000187:drug effects / Q000528:radiation effects*; D004921:Erythropoietin / Q000494:pharmacology*; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology*; D000860:Hypoxia / Q000503:physiopathology; D007501:Iron / Q000097:blood; D051379:Mice
D004921:Erythropoietin; D007501:Iron; D005472:Fluorouracil