Development of clear cell adenocarcinoma in DES-exposed offspring under observation.
Two cases of clear cell adenocarcinoma of the vagina detected at follow-up in young women exposed in utero to diethylstilbestrol are reported. One patient, aged 23, had been followed for 2 years before carcinoma was diagnosed; the second patient, aged 22, had been seen on a regular basis for 5 years, 8 months. In both instances, suspicion of the presence of carcinoma was aroused by the palpation of a small nodule in the vaginal fornix. Hysterosalpingography was performed on both patients and, in 1 instance, an abnormal x-ray film was reflected by the gross appearance of the uterine cavity found in the surgical specimen.
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology; D000328:Adult; D001706:Biopsy; D004054:Diethylstilbestrol / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D014625:Vaginal Neoplasms / Q000139:chemically induced* / Q000473:pathology
D004054:Diethylstilbestrol