Lack of an effect of saline loading on glycerol-induced acute renal failure.
To determine whether saline loading actually protects against acute renal failure, both C and BUN were measured in rats drinking either tap water or 1% saline for 1-3 months. At 24 and 48 h after an injection of 10 ml/kg i.m. of 50% glycerol in water, CTN was equally reduced in saline-drinking and water-drinking rats as compared to uninjected rats. The daily intraperitoneal injection of saline for 1-3 months also was not protective. At 48 hours after glycerol injection, the BUN concentration in saline-drinking rats was significantly lower than in water-drinking rats. This was probably due to the greater renal urea clearance in these animals. We conclude from these findings that saline loading does not protect against glycerol-induced acute renal failure in the rat although it affects the Curea and Bun concentration.
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000517:prevention & control* / Q000652:urine; D000818:Animals; D001806:Blood Urea Nitrogen; D005990:Glycerol; D007444:Inulin / Q000097:blood / Q000652:urine; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000097:blood / Q000652:urine; D012965:Sodium Chloride / Q000008:administration & dosage*; D014508:Urea / Q000097:blood / Q000652:urine
D012965:Sodium Chloride; D014508:Urea; D007444:Inulin; D012964:Sodium; D005990:Glycerol