[Glycolysis components and carbohydrate metabolic enzyme activity of the blood under long-term action of rifampicin and isoniazid].
Long-term administration of therapeutic doses of rifampicin and isoniazid or their combination induces an activation of NAD-dependent enzymes in the plasma and red cells of experimental rats. The ATP/ADP ratio decrease in all the experimental groups, while the degree of pyridine nucleotide reduction rises due to a combined action of the drugs. This effect is similar to the state of hypoxia.
D000818:Animals; D002241:Carbohydrates / Q000097:blood*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004789:Enzyme Activation / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects*; D007538:Isoniazid / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D012293:Rifampin / Q000627:therapeutic use*; D013997:Time Factors
D002241:Carbohydrates; D007538:Isoniazid; D012293:Rifampin
Komponenty glikoliza i aktivnost' nekotorykh fermentov uglevodnogo obmena v krovi pri dlitel'nom deĭstvii rifampitsina i izoniazida.