Superoxide dismutase in various tissues from rabbits bearing the Vx-2 carcinoma in the maxillary sinus.
Distribution profiles of superoxide dismutase isoenzymes in various tissues of rabbits with the Vx-2 carcinoma in the maxillary sinus were compared with those of control rabbits. Copper- and zinc-containing superoxide dismutase (Cu,Zn-SOD) activity in the liver of rabbits decreased significantly 3 weeks after transplantation. Manganese-containing superoxide dismutase (Mn-SOD) activity did not decrease significantly within 5 weeks after transplantation. In other tissues from the tumor-bearing rabbits, Cu,Zn-SOD and Mn-SOD activities were not changed within 5 weeks. No Mn-SOD activity and low Cu,Zn-SOD activity were detected in the Vx-2 carcinoma. These results suggest that the Vx-2 carcinoma has lost most of its ability to defend against oxygen toxicity and this ability decreased only in the liver of rabbits bearing the Vx-2 carcinoma in the maxillary sinus.
D000818:Animals; D007527:Isoenzymes / Q000378:metabolism; D008443:Maxillary Sinus / Q000201:enzymology*; D009374:Neoplasms, Experimental / Q000201:enzymology; D010255:Paranasal Sinus Neoplasms / Q000201:enzymology*; D011817:Rabbits; D013482:Superoxide Dismutase / Q000378:metabolism*; D014018:Tissue Distribution
D007527:Isoenzymes; D013482:Superoxide Dismutase