The correlation of ultrasonic placental grading and fetal pulmonary maturation in five hundred sixty-three pregnancies.
In a previous study, it was suggested that the presence of a grade III placenta correlates 100% with a mature lecithin/sphingomyelin (L/S) ratio and may replace amniocentesis in confirming fetal lung maturity. In this study that hypothesis was tested in 563 pregnancies. All patients underwent amniocentesis and simultaneously had placental grading. The correlations of placental grade with an L/S ration greater than or equal to 2 were: grade 0, 17%; grade I, 68%; grade II, 91%. The correlations of placental grade with the presence of phosphatidylglycerol (PG) were: grade 0, 17; grade 1, 41%; grade II, 79%; grade II, 75%. The false positive rates associated with grade III placenta were, therefore, 7% for mature L/S ratio and 25% for PG present: when combined with a biparietal diameter greater than or equal to 9.0 cm, a grade III placenta incorrectly predicted lung maturity in 8.5%. We conclude that placental grading is not accurate enough to replace amniocentesis as the standard test of fetal pulmonary maturity.
D000649:Amniocentesis; D005260:Female; D005325:Fetal Organ Maturity; D006801:Humans; D008168:Lung / Q000196:embryology*; D010712:Phosphatidic Acids / Q000032:analysis; D010713:Phosphatidylcholines / Q000032:analysis; D010920:Placenta / Q000033:anatomy & histology*; D011247:Pregnancy; D014463:Ultrasonography
D010712:Phosphatidic Acids; D010713:Phosphatidylcholines