[Acute and chronic toxicology of different staphylococcal immune preparations].
The data obtained of the acute and chronic toxicity of a number of staphylococcal immune preparations are presented. The paw edema test has been shown to yield more informative results for the evaluation of acute toxicity than the method of intraperitoneal injection and LD50 determination. The paw edema test has revealed that the toxicity of corpuscular vaccine is higher than that of the preparations of water-soluble antigenic staphylococcal complexes. The chronic toxicity test has demonstrated that corpuscular vaccine, antiphagin, adsorbed toxoid and the antigenic complex have low toxicity: their multiple administration in doses exceeding the equivalent doses 30-200 times have been found to exert no influence on the increase of the weight of the animals.
D000327:Adsorption; D000818:Animals; D000942:Antigens, Bacterial / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D004306:Dose-Response Relationship, Immunologic; D004487:Edema / Q000209:etiology; D005121:Extremities; D007274:Injections, Intraperitoneal; D051379:Mice; D013208:Staphylococcal Toxoid / Q000633:toxicity*; D013209:Staphylococcal Vaccines / Q000633:toxicity*; D013210:Staphylococcus / Q000276:immunology*; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000633:toxicity
D000942:Antigens, Bacterial; D013208:Staphylococcal Toxoid; D013209:Staphylococcal Vaccines; D014613:Vaccines, Attenuated; C034359:antifagin
Ostraia i khronicheskaia toksichnost' razlichnykh stafilokokkovykh immunopreparatov.