Ontogenic changes in selenite metabolism in rats.
Radioselenium concentration and excretion was studied after administration of 75SE-labelled selenite to male rats during ontogeny. The concentration of radioselenium in individual organs decreases with increasing age. The largest differences between young and adults were in the quantity and quality of excreted substances. During 2 h after the administration of 20 mumol selenite/kg young rats excreted 2.4% of the dose, essentially in the urine only, whilst adults excreted a total of 11%, distributed equally in breath and urine. The part excreted as methylated metabolites was 0.1% of the administered dose in young and 6.3% in adult rats. These results support the hypothesis that the differences in the sensitivity to the toxic action of selenite between young and adult rats can be due to ontogenic differences in selenium metabolism.
D000375:Aging; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D009942:Organometallic Compounds / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium / Q000032:analysis / Q000378:metabolism*; D018036:Selenium Compounds; D014018:Tissue Distribution
D009942:Organometallic Compounds; D018036:Selenium Compounds; D012643:Selenium; C003717:trimethylselenonium