Effects of triethyltin on schedule dependent and schedule induced behaviors under different schedules of reinforcement.
The subacute effects of triethyltin (TET) on operant responding and adjunctive behavior were assessed using either a fixed ratio (FR-30) or fixed interval (FI-1 min) schedule of reinforcement. Response rate decreased for rats on the FR-30 schedule given 1.5 mg/kg whereas animals on the FI-1 min schedule showed decreases in presses and pellets obtained at 1.5 mg/kg and in water intake at 1.0 and 1.5 mg/kg. When the animals on the FI-1 min schedule were allowed to recover body weight, decreases in presses, pellets obtained, licking, and water intake occurred at 0.5, 1.0 and 1.5 mg/kg. Schedule induced and schedule dependent behaviors were affected by low doses of TET. Rats at recovered body weight were most sensitive and affected by the lowest TET doses.
D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight; D003216:Conditioning, Operant / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects; D008297:Male; D014677:Pharmaceutical Vehicles; D051381:Rats; D011919:Rats, Inbred Strains; D012055:Reinforcement Schedule; D014220:Trialkyltin Compounds / Q000633:toxicity*; D014267:Triethyltin Compounds / Q000633:toxicity*
D014677:Pharmaceutical Vehicles; D014220:Trialkyltin Compounds; D014267:Triethyltin Compounds