Necessity of bile for and lack of inhibitory effect of retinoid on development of forestomach papillomas in nontreated mutant mice of the W/Wv genotype.
The pathogenesis of papillomas which developed spontaneously in the forestomach of WB X C57BL/6 F1-W/Wv mutant mice was investigated. The thickness of the forestomach epithelium was used as a quantitative index for development of papillomas. From the 15th day after birth, the forestomach epithelium of the W/Wv mice was significantly thicker than that of the congenic +/+ mice. Administration of aromatic retinoic acid analog (ethyl all-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-3,7-dimethyl-2,4,6,8 -nonatetraenoate) did not suppress development of papillomas. Since papillomas did not appear in the stomach which was removed from the W/Wv embryos and grafted to the s.c. space produced in the back of the adult mice and since a considerable amount of bile reflux preceded development of papillomas, bile reflux may be a cause of papillomas in W/Wv mice.
D000483:Alleles; D000818:Animals; D001655:Bile Reflux / Q000150:complications*; D001660:Biliary Tract Diseases / Q000150:complications*; D005050:Etretinate / Q000494:pharmacology*; D005260:Female; D005838:Genotype; D008297:Male; D051379:Mice; D009154:Mutation; D010212:Papilloma / Q000209:etiology* / Q000235:genetics; D013270:Stomach / Q000637:transplantation; D013274:Stomach Neoplasms / Q000209:etiology* / Q000235:genetics; D014212:Tretinoin / Q000031:analogs & derivatives*
D014212:Tretinoin; D005050:Etretinate