Effects of kainic acid on high-energy metabolites in the mouse striatum.
Intrastriatal injection of either kainic acid (0.35 micrograms) or ibotenic acid (7.0 micrograms) in the mouse causes a profound and selective degeneration of striatal neurons accompanied by a secondary astrocytic response. The kainate injection (0.35 micrograms) resulted in significant decrements in the striatal levels of phosphocreatine and ATP by 30 min. a progressive reduction in adenosine phosphates between 30 min and 48 h, and a decrease in energy charge; whereas lactate levels increased by 44% at 2 h, glucose levels fell by 56%. Two hours after intrastriatal injection of ibotenic acid (7.0 micrograms) similar alternations in striatal high-energy phosphates and glucose disposition were found. Prior decortication protected against the neurotoxic effects of kainate in the mouse striatum and prevented the alterations in high-energy phosphates at 2 h although lactate levels increased by 212%. These findings in vivo are consistent with the hypothesis that the neurotoxic effects of acidic excitatory amino acids involve a profound activation of energy consumption by affected neurons.
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000201:enzymology; D004734:Energy Metabolism / Q000187:drug effects*; D005947:Glucose / Q000378:metabolism; D007051:Ibotenic Acid / Q000494:pharmacology; D007276:Injections, Intraventricular; D007608:Kainic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D051379:Mice; D010725:Phosphocreatine / Q000378:metabolism; D011759:Pyrrolidines / Q000494:pharmacology*
D000227:Adenine Nucleotides; D007773:Lactates; D011759:Pyrrolidines; D010725:Phosphocreatine; D007051:Ibotenic Acid; D019344:Lactic Acid; D005947:Glucose; D007608:Kainic Acid