Cyclophosphamide-induced glomerular injury in newborn mice.
The glomeruli of newborn mice from mothers given a single intraperitoneal injection of cyclophosphamide (50 or 110 mg. per kg.) showed varying degrees of mesangiolysis and subsequent diffuse mesangial and segmental sclerosis. The sclerosis was preceded by the formation of a considerable amount of mesangial microfibrils. This change was accompanied by a marked subendothelial widening of the glomerular capillary and an increase in the number of microfibrils in this space. These results support our previous notion that glomerular microfibrils play an important role in the process of glomerular repair. The results also show that cyclophosphamide can induce injury in the developing glomeruli of newborn mice.
D000818:Animals; D000831:Animals, Newborn; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D007274:Injections, Intraperitoneal; D007678:Kidney Glomerulus / Q000187:drug effects*; D051379:Mice; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D003520:Cyclophosphamide