Altered methionyl-tRNA synthetase in a Spirulina platensis mutant resistant to ethionine.
Compared with the parental strain, a Spirulina platensis mutant that is resistant to ethionine incorporated methionine into protein at a reduced rate, whereas ethionine incorporation was practically nil. The methionyl-tRNA synthetase present in crude extracts from the resistant strain showed a reduced affinity for methionine and ethionine.
D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism*; D041964:Cytophagaceae / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D004352:Drug Resistance, Microbial; D005001:Ethionine / Q000378:metabolism / Q000494:pharmacology*; D008715:Methionine / Q000378:metabolism; D008718:Methionine-tRNA Ligase / Q000378:metabolism*; D009154:Mutation
D008715:Methionine; D000604:Amino Acyl-tRNA Synthetases; D008718:Methionine-tRNA Ligase; D005001:Ethionine