The effect of short-term and prolonged fructose intake on VLDL-TG and relative properties on apo CIII1 and apo CII in the VLDL fraction in type IV hyperlipoproteinaemia.
Twenty two patients with hyperlipoproteinaemia type IV consumed fructose in a daily dose of 80 g for 28 days. Apart from that they kept their normal diet. We observed the considerable heterogeneity of hyperlipaemic responses of patients under study after 7 days of fructose feeding. However VLDL-TG and the relative ratio apo CIII1/apo CII in VLDL increased in the whole group. The rise in serum VLDL was associated with a fall in LDL-Chol and HDL-Chol. After extention of fructose intake to 28 days a decrease of VLDL-TG with concomitant fall of the relative ratio apo CIII1/apo CII in VLDL was found. LDL-Chol increased. Our observations point to the reversibility of fructose-induced changes in the lipoprotein composition after prolongation of its intake.
D000328:Adult; D000368:Aged; D053304:Apolipoprotein C-II; D053305:Apolipoprotein C-III; D001053:Apolipoproteins / Q000097:blood; D001056:Apolipoproteins C; D002784:Cholesterol / Q000097:blood; D004040:Dietary Carbohydrates / Q000494:pharmacology; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D006953:Hyperlipoproteinemia Type IV / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014280:Triglycerides / Q000097:blood*
D053304:Apolipoprotein C-II; D053305:Apolipoprotein C-III; D001053:Apolipoproteins; D001056:Apolipoproteins C; D004040:Dietary Carbohydrates; D008074:Lipoproteins; D008079:Lipoproteins, VLDL; D014280:Triglycerides; C030104:lipoprotein cholesterol; C030106:very low density lipoprotein triglyceride; D005632:Fructose; D002784:Cholesterol