possible role of a retrovirus in the expression of tumor-specific antigens of the Meth A sarcoma.
The serologically defined tumor-specific surface antigen (TSSA) of the chemically-induced BALB/c Meth A sarcoma, highly restricted to one of 20 sarcomas of BALB/c origin, has been detected on a Moloney murine sarcoma virus (Mo-MuSV)-transformed BALB/c 3T3 cell lines, designated IIA(v). The immunogenicity of the IIA(v) cell in tumor-rejection assays was specific for the Meth A sarcoma, supporting the evidence for a close relationship between the TSSA and the tumor-associated transplantation antigen (TATA) of this tumor. Infection of SC-I cells with retroviruses present in cultured filtrates of IIA(v) cells resulted in Meth A antigen expression. The retroviruses associated with Meth A antigen expression have been tentatively identified as replication and/or transformation-defective XC- MuLV. The possible roles of Mo-MuSV and cellular genes of the BALB/c strain of mice in the expression of the Meth A antigen are discussed.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D002460:Cell Line; D002472:Cell Transformation, Viral; D005260:Female; D006649:Histocompatibility Antigens / Q000276:immunology*; D008748:Methylcholanthrene; D051379:Mice; D008807:Mice, Inbred BALB C; D008979:Moloney murine leukemia virus / Q000276:immunology*; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000139:chemically induced* / Q000276:immunology
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D006649:Histocompatibility Antigens; C029237:tumor-associated transplantation antigen; D008748:Methylcholanthrene