The effects of postligation administration of ORG 6001 and disopyramide on early ischaemia-induced arrhythmias in the anaesthetized rat.
The effects of intravenous doses of Org 6001 and disopyramide (10 mg/kg) known to confer protection against early postligation-induced arrhythmias in the anaesthetized rat when given prophylactically, were assessed following postligation administration. When given 1 min after ligation both drugs greatly reduced the incidence of ventricular fibrilloflutter and completely prevented electrical deaths (45% in the controls). Protection was also seen when the drugs were given just before the expected onset of arrhythmias (4.5 min postligation).
D000732:Androstanols / Q000627:therapeutic use*; D000758:Anesthesia; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000503:physiopathology / Q000517:prevention & control*; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy*; D003331:Coronary Vessels / Q000502:physiology; D004206:Disopyramide / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D008026:Ligation; D008297:Male; D011725:Pyridines / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D014693:Ventricular Fibrillation / Q000139:chemically induced
D000732:Androstanols; D000889:Anti-Arrhythmia Agents; D011725:Pyridines; D004206:Disopyramide; C010158:amafolone