[Studies on the therapeutics of experimental toxoplasmosis. II. Effect of acetylspiramycin alone or in combination with an immunopotentiator (CSP-II) or sulfamethopyrazine on Toxoplasma multiplication in the heart of mice acutely and chronically infected with Toxoplasma gondii (author's transl)].
Normal mice acutely and chronically infected with the S-273 strain of T. gondii, were treated with acetylspiramycin (ASPM) alone, 8 mg/mouse/day, per os, or in combination with an immunopotentiator (CSP-II), 10 mg/mouse/day, intraperitoneally, or sulfamethopyrazine (SMPZ), 2 mg/mouse/day, per os, for a period of 4 weeks. In the acute cases, a 99.4% cyst reduction was obtained with ASPM alone and no cysts were seen in the brains of mice treated with ASPM in combination with CSP-II or SMPZ. The organisms were significantly eradicated in the brain and heart tissues of mice treated with ASPM alone or in combination with CSP-II or SMPZ as shown by subinoculation to normal mice and the negative latex hemagglutination titers of the recipient mice. In the chronic cases, a cyst reduction of 52.4% was obtained with mice treated with ASPM in combination with CSP-II. A cyst reduction of 34.6%, 32.9% and 20.8% was obtained in the ASPM alone, CSP-II alone and ASPM in combination with SMPZ treated groups, respectively. A comparative clearing of the organisms in the heart tissues of mice treated with ASPM in combination with CSP-II was obtained compared to the other treatment groups but not in the brains of all groups.
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D001921:Brain / Q000469:parasitology; D004359:Drug Therapy, Combination; D005260:Female; D006321:Heart / Q000469:parasitology*; D007933:Leucomycins / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015572:Spiramycin / Q000031:analogs & derivatives*; D013421:Sulfamethoxypyridazine / Q000008:administration & dosage*; D014122:Toxoplasma / Q000254:growth & development; D014124:Toxoplasmosis, Animal / Q000188:drug therapy* / Q000469:parasitology
D000276:Adjuvants, Immunologic; D007933:Leucomycins; C033163:acetylspiramycin; D015572:Spiramycin; D013421:Sulfamethoxypyridazine