Structural requirements for neuraminidase induction in Arthrobacter sialophilus.
The effectiveness of 13 N-acetylneuraminic acid derivatives as potential inducers of Arthrobacter sialophilus neuraminidase were examined. N-Acetylneuraminic acid nitrogen and thioglycosides were not inducers, whereas 2,3-dehydro-N-acetylneuraminic acid, a transition state analog for neuraminidases, was the most effective inductive ligand. The C-4 hydroxyl function of N-acetylneuraminic acid was essential for enzyme derepression.
D001173:Arthrobacter / Q000201:enzymology*; D055598:Chemical Phenomena; D002621:Chemistry; D004790:Enzyme Induction; D009439:Neuraminidase / Q000096:biosynthesis*; D012794:Sialic Acids / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D012794:Sialic Acids; D009439:Neuraminidase