Experience with activated carbon-bead haemoperfusion columns in the treatment of severe drug intoxication. A preliminary report.
Five patients who were severely poisoned with hypnotic drugs, paracetamol, or theophylline were treated by charcoal haemoperfusion. The device contained 160 g of activated carbon beads with a polyester coating. Four patients made a significant improvement; one subsequently died from a cerebral haemorrhage which had occurred prior to haemoperfusion. Platelet losses were minimal and no fibrinolysis was observed. No significant biochemical abnormality occurred as a result of haemoperfusion, although one patient, who presented with hypocalcaemia, required intravenous calcium throughout the procedure.
D000082:Acetaminophen / Q000097:blood / Q000506:poisoning; D000293:Adolescent; D000328:Adult; D000368:Aged; D002606:Charcoal / Q000627:therapeutic use*; D005260:Female; D005984:Glutethimide / Q000097:blood / Q000506:poisoning; D006464:Hemoperfusion; D006801:Humans; D010634:Phenobarbital / Q000097:blood / Q000506:poisoning; D011041:Poisoning / Q000628:therapy*; D013806:Theophylline / Q000097:blood / Q000506:poisoning
D002606:Charcoal; D000082:Acetaminophen; D013806:Theophylline; D005984:Glutethimide; D010634:Phenobarbital