Molecular weight and therapeutic dose of drug.
This report presents statistically significant empirical correlations between the potency (as expressed by log 1/C) and the molecular weight (log M.W.) of water soluble vitamins, various centrally acting drugs and anticancer agents. The implications of these correlations are discussed in terms of protein binding, renal elimination and drug-receptor binding. The limitations of this type of correlation are also presented.
D000970:Antineoplastic Agents / Q000008:administration & dosage; D002490:Central Nervous System / Q000187:drug effects; D004358:Drug Therapy; D006801:Humans; D008970:Molecular Weight; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D014815:Vitamins / Q000008:administration & dosage
D000970:Antineoplastic Agents; D004364:Pharmaceutical Preparations; D014815:Vitamins