Effects of chronic manganese (Mn3O4) exposure on selected reproductive parameters in rats.
Long-Evans rats were chronically exposed to dietary Mn3O4 beginning on d 1 of gestation and continuing through 224 d of age. Dietary concentrations of Mn, as Mn3O4, were 350, 1050, and 3500 ppm and were applied in either a normal Fe 240 ppm) or a low-Fe (20 ppm) basal diet. General toxic effects were apparent in young animals at a dietary dose of 3500 ppm Mn and were enhanced by concomitant Fe deficiency. Fertility was reduced in the group exposed to 3500 ppm Mn with a diet containing sufficient Fe. Male reproductive development was delayed by Mn treatment, as measured by testes weight, sperm count, and serum follicle-stimulating hormone and testosterone concentrations.
D000818:Animals; D005260:Female; D000090463:Iron Deficiencies; D008297:Male; D008345:Manganese / Q000378:metabolism / Q000494:pharmacology*; D017895:Manganese Compounds; D010087:Oxides; D010316:Particle Size; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D013737:Testis / Q000187:drug effects; D013997:Time Factors; D014018:Tissue Distribution
D017895:Manganese Compounds; D010087:Oxides; D008345:Manganese; C027424:manganese oxide