Gas chromatographic-mass spectrometric analysis of organic acids in renal tissue biopsy: identification of 4-hydroxybutyric acid and 4-hydroxy-2-butenoic acid.
The organic acids in renal tissue biopsy (0.5-1 mg) obtained from chronic glomerulonephritis patients were analyzed capillary column gas chromatography--mass spectrometry. Some twenty compounds were identified in the renal tissue. The organic acid profile of renal tissue showed a marked difference from those of urine and serum. In particular, 4-hydroxybutyric acid and 4-hydroxy-2-butenoic acid, which are usually undetectable in urine and serum, were detected for the first time in renal tissue in considerably large amounts.
D001706:Biopsy; D008401:Gas Chromatography-Mass Spectrometry; D005921:Glomerulonephritis / Q000378:metabolism; D006801:Humans; D006885:Hydroxybutyrates / Q000032:analysis*; D007668:Kidney / Q000032:analysis*; D012978:Sodium Oxybate
D006885:Hydroxybutyrates; C035142:4-hydroxy-2-butenoic acid; D012978:Sodium Oxybate