Ionic shift in cerebral ischemia.
Electrolyte and water contents were measured in gerbil brain after unilateral cerebral ischemia. Increase of Na+ and water, and decrease of K+ occurred after an ischemic period of 30 minutes. However, these abnormalities disappeared within 3 hours. When the ischemic period was extended to 3 hours, the abnormalities observed after ischemia for 30 minutes were again encountered, but more significant alterations occurred immediately after re-establishment of blood flow. In addition to more pronounced increase of Na+ and decrease of K+, Ca2+ became significantly elevated after recirculation for 15 minutes and progressively increased during recirculation for 3 hours. The steady rise of Ca2+ appears to be related to the irreversibility of cerebral ischemia.
D000818:Animals; D001834:Body Water / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D002339:Carotid Arteries / Q000502:physiology; D004573:Electrolytes / Q000378:metabolism*; D005849:Gerbillinae; D002546:Ischemic Attack, Transient / Q000378:metabolism*; D007700:Kinetics; D008274:Magnesium / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D004573:Electrolytes; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium