Hydrogen ion dynamics and cancer: an appraisal.
The concentration of hydrogen ions plays a critical role in all biochemical processes, including multiple enzymatic reactions, and in the regulation of metabolism. The acid-base aspects of metabolism as applied to cancer are considered. Preliminary data are presented. The primary concept of hydrogen ion dynamics is related to prevention, development, and etiology of carcinogenicity, as well as to the regression of certain malignant malignant tumors. The present overview summarizes, in terms of H+ dynamics, many related concepts in oncologic research and associates and integrates a variety of basic and clinical observations toward better understanding of cancer cell behavior, biology, and host-tumor relationships.
D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000209:etiology; D000818:Animals; D004247:DNA / Q000096:biosynthesis; D004285:Dogs; D006019:Glycolysis; D006358:Hot Temperature / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000097:blood; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D010101:Oxygen Consumption; D011773:Pyruvates / Q000097:blood; D051381:Rats; D012907:Smoking
D007773:Lactates; D011773:Pyruvates; D004247:DNA