Suicidal digoxin poisoning: conventional treatment and antibody therapy.
A 66-year-old mand suffering from severe coronary heart disease took digoxin with suicidal intent an was treated for the ensuing complete atrioventricular block with digoxin-specific antibody fragments. Two and a half hours after intravenous infusion of the antibody fragments, the signs of intoxication passed off, and atrial fibrillation with a normal ventricular rate was reinstated. Antibody therapy is capable of permanently abolishing the signs of symptoms of digitalis poisoning after a matter of hours. Such a rapid or complete response cannot be achieved by any conventional form of treatment. This advantage must be weighed against the risks (immunologic reactions, loss of the therapeutic effect of the cardiac glycoside if an overdose of antibody is given). Moreover, antibody therapy does not take effect immediately, as is understandable in view of the mechanism of action. It should therefore be instituted in good time in potentially life-threatening cases of intoxication.
D000368:Aged; D000906:Antibodies / Q000008:administration & dosage*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D004077:Digoxin / Q000276:immunology / Q000506:poisoning* / Q000627:therapeutic use; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000008:administration & dosage*; D008297:Male; D013406:Suicide, Attempted; D014882:Water-Electrolyte Balance / Q000187:drug effects
D000906:Antibodies; D007140:Immunoglobulin Fab Fragments; D004077:Digoxin