CK-MB isoenzyme in patients with polymyositis.
Total serum creatine kinase and isoenzyme levels were studied in five patients with polymyositis. In all five patients, CK-MB isoenzyme was demonstrated by the column chromatography and electrophoretic method, although there was no evidence of myocardial infarction. The persistent elevation of CK-MB in patients with polymyositis is in contrast to the usual transient increase in myocardial infarction. Serial CK-MB isoenzyme quantitation can be used to distinguish myocardial infarction from polymyositis. CK-MB is a more sensitive indicator than AST and LDH as a monitoring device, but offers no advantage over total CK activity.
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D003402:Creatine Kinase / Q000032:analysis*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008875:Middle Aged; D009220:Myositis / Q000188:drug therapy / Q000201:enzymology*
D000305:Adrenal Cortex Hormones; D007527:Isoenzymes; D003402:Creatine Kinase