[Raised plasma glucagon levels in obesity (author's transl)].
Plasma glucagon levels were measured in 129 grossly obese patients with 77 +/- 29% excess weight according to Broca. A significantly raised basal glucagon level (179 +/- 7 pg/ml) was found when compared with normal weight controls (109 +/- 7 pg/ml). Weight reduction of 9.1 +/- 3.8 kg with reduction of glucose-stimulated hyperinsulinaemia from 97 +/- 12 microU/ml to 62 +/- 6 microU/ml had no influence on hyperglucagonaemia. A subgroup of obese patients with hypertriglyceridaemia (270 +/- 24 mg/dl) and glucose intolerance had particularly high plasma glucagon levels (198 +/- 12 pg/ml). It seems that these patients have a resistance to glucagon in addition to a marked insulin resistance.
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D005260:Female; D005934:Glucagon / Q000097:blood*; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000178:diet therapy; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D014280:Triglycerides; D005934:Glucagon
Erhöhte Plasma-Glucagonspiegel bei Adipositas.