[Enzymes of the detoxication of active forms of oxygen and lipoperoxides in experimental ischemia and myocardial infarct].
Variation in the activity of superoxide dismutase, glutathione peroxidase (tretbutyl hydroperoxide as a substrate) and glutathione-S-transferase (1-chloro-2,4-dinitrobenzene as a substrate) was studied in rat ischemia and in coronaro-occlusion myocardial infarction. The activity of superoxide dismutase and glutathione peroxidase drastically reduced 2-15 minutes after ligation of the coronary artery and remained at the decreased level during the observation period (14 days). The activity of glutathione-S-transferase in the infarcted zone of the myocardium significantly decreased only by day 3 of the experiment. The activity of glutathione peroxidase in the blood of patients with acute myocardial infarction rose more than 1.5-fold.
D000818:Animals; D003327:Coronary Disease / Q000201:enzymology*; D005979:Glutathione Peroxidase / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology; D010101:Oxygen Consumption; D010544:Peroxidases / Q000378:metabolism*; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism*; D013997:Time Factors
D008054:Lipid Peroxides; D010544:Peroxidases; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase
Fermenty detoksikatsii aktivnykh form kisloroda i lipoperekisseĭ pri éksperimental'noĭ ishemii i infarkte miokarda.