[Uptake of Testosterone-1 alpha, 2 alpha-3H(n) by target organ tissues of guinea pig embryos in vitro].
The dynamics of testosterone-1 alpha, 2 alpha-3H(n) intake by different tissues of genital tract was studied in the guinea pig embryos from the 23rd day of development till birth. The specific intake was noted at all developmental stages studied and in all genital tract rudiments. The Selective intake was observed in the male embryos in the genital tubercle from the 29th day, in the ducts from the 46th day and in the urogenital sinus from the 26th day. In the female embryos it was found in the genital tubercle on the 26--28th day and from the 35th, in the ducts from the 46th day and in the urogenital sinus on the 32--35th, 46--50th days and prior to birth. The specific intake was also observed in the gonads of embryos of both sexes. The data obtained suggest the presence of reception to androgen prior to the beginning of morphogenesis of the genital system and the acquisition of increase sensitivity to the hormone in the homologous rudiments during the critical periods of differentiation of organ targets by the male type.
D000818:Animals; D002454:Cell Differentiation; D005260:Female; D005835:Genitalia / Q000196:embryology* / Q000378:metabolism; D005865:Gestational Age; D006168:Guinea Pigs; D008297:Male; D009132:Muscles / Q000196:embryology; D011944:Receptors, Androgen; D011987:Receptors, Steroid / Q000032:analysis*; D012737:Sex Factors; D013739:Testosterone / Q000378:metabolism*; D014566:Urogenital System / Q000196:embryology / Q000378:metabolism
D011944:Receptors, Androgen; D011987:Receptors, Steroid; D013739:Testosterone
Pogloshchenie testosterona-1 alpha, 2 alpha-3H(n) tkaniami organov-misheneĭ u zarodysheĭ morskoĭ svinki in vitro.