Effect of infusing the branched-chain amino acids on concentrations of amino acids in plasma and brain and on brain catecholamines after total hepatectomy in the rat.
In totally hepatectomized rats supported by infusion of glucose, the concentrations of many amino acids in plasma and brain rose progressively over time, while the brain levels of norepinephrine decreased. Infusion of a solution containing glucose, leucine, isoleucine, and valine after hepatectomy greatly reduced the accumulation of other essential amino acids in plasma and brain. However, the decrease in brain norepinephrine content was not significantly affected by this infusion, suggesting that high brain concentrations of monoamine precursor amino acids are not the primary cause of norepinephrine depletion after hepatectomy.
D000596:Amino Acids / Q000032:analysis / Q000097:blood*; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001923:Brain Chemistry; D002395:Catecholamines / Q000032:analysis*; D004298:Dopamine / Q000032:analysis; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology; D006498:Hepatectomy; D007263:Infusions, Parenteral; D008297:Male; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D002395:Catecholamines; D005947:Glucose; D004298:Dopamine; D009638:Norepinephrine