Effect of oral cadmium administration to female rats before and/or during pregnancy on the metallothionein level in the fetal liver.
Female Wistar rats received cadmium (Cd) in drinking water at a concentration of 100 ppm before and during pregnancy, prior to gestation only, and during gestation only. For the quantitative determination of metallothionein, the 203Hg-saturation method was used. Each of the 3 exposure treatments led to a decrease of the fatal metallothionein level, which may be due to disturbance in hepatic zinc (Zn) metabolism.
D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D005260:Female; D008099:Liver / Q000196:embryology / Q000378:metabolism*; D008631:Mercury Radioisotopes; D008667:Metalloproteins / Q000378:metabolism*; D008668:Metallothionein / Q000378:metabolism*; D008970:Molecular Weight; D009929:Organ Size; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D011919:Rats, Inbred Strains
D008631:Mercury Radioisotopes; D008667:Metalloproteins; D002104:Cadmium; D008668:Metallothionein