Kinetics of osmotically controlled indomethacin delivery systems after repeated dosing.
Two osmotically driven, controlled-release dosage forms of indomethacin were evaluated in a multiple-dose crossover study in 12 healthy subjects. Following equivalent daily doses, less frequent dosing of both controlled-release forms resulted in plasma concentration profiles that are more uniform than those following capsule regimens. After the first day, morning predose plasma levels wer significantly higher for the controlled-release treatments. Renal clearances were similar between days and among treatments. Total urinary recoveries were comparable for all regimens.
D003692:Delayed-Action Preparations; D004304:Dosage Forms; D005069:Evaluation Studies as Topic; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000378:metabolism*; D007700:Kinetics; D011897:Random Allocation
D003692:Delayed-Action Preparations; D004304:Dosage Forms; D007213:Indomethacin