Fasting accelerates the in vivo metabolism of carbon tetrachloride in rats.
Exposure of fed and fasted rats to CC1(4) vapor (114 ppm) for 6 h in a closed system increased serum enzyme activities (GOT, GPT, SDH) only in fasted animals. The in vivo metabolism of CC1(4), studied in the same system, was accelerated by fasting; the half-life of the elimination phase being reduced by approx. 33%. The enhanced susceptibility to CC1(4) induced by fasting seemed to be due to the accelerated bioactivation of CC1(4) to the toxic trichloromethyl free radical.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002251:Carbon Tetrachloride / Q000378:metabolism*; D005215:Fasting; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase