A new model for arteriosclerosis. An electron-microscopic study of the lesions induced by i.v. administered fat.
Lesions in the arterial wall induced in rats by means of intravenous injection of Lipofundin-S were studied by electron microscopy. The morphological changes in this model are the enlargement of the subendothelial space, proliferation of smooth muscle and accumulation of basement membrane-like material. These changes are a closer model for the fibro-proliferative aspects of human atherosclerosis than those seen in short-term (2-3 month) cholesterol feeding. Moreover, such changes are produced in 8 days rather than 2-3 month. These factors indicate that the Lipofundin-S model may be of value in testing anti-atherosclerotic drugs.
D000818:Animals; D001011:Aorta / Q000648:ultrastructure; D001161:Arteriosclerosis / Q000473:pathology*; D001485:Basement Membrane / Q000648:ultrastructure; D004041:Dietary Fats / Q000494:pharmacology*; D004195:Disease Models, Animal; D004727:Endothelium / Q000648:ultrastructure; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D009131:Muscle, Smooth, Vascular / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains
D004041:Dietary Fats