Reiter's syndrome: a male and female disease.
A diagnosis of Reiter's syndrome was made in 12 males and 13 females based on an asymmetrical oligoarthritis with lower extremity predominance and at least 1 characteristic extraarticular manifestation. The pattern of disease was similar in both sexes; females had more extensive upper extremity joint involvement and ocular inflammation; males had more nonbacterial urethritis. Eighty-two % of males and 62% of females were HLA-B27 positive. We suggest that Reiter's syndrome has not been diagnosed in more females in the past because of an historical bias, a reliance on the complete classical triad, and confusion with seronegative rheumatoid arthritis.
D000293:Adolescent; D000328:Adult; D016918:Arthritis, Reactive / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D001799:Blood Sedimentation; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013582:Synovial Fluid / Q000473:pathology
D006680:HLA Antigens