Doxepin and cimetidine in the treatment of duodenal ulcer: an open clinical and endoscopic study.
In an open clinical endoscopic study, 50 patients with duodenal ulcer showed no significant difference in ulcer healing during a 6-week treatment period with doxepin HCl (50 mg h.s.) versus cimetidine (1000 mg/day in divided doses). Possible tricyclic mechanisms of action in the treatment of peptic ulcer, e.g., histamine H2 blockade, are discussed.
D000328:Adult; D000368:Aged; D002927:Cimetidine / Q000627:therapeutic use*; D004316:Doxepin / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000473:pathology; D004384:Duodenoscopy; D005744:Gastric Acid / Q000378:metabolism; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D011897:Random Allocation; D011970:Receptors, Histamine H2 / Q000187:drug effects
D006146:Guanidines; D011970:Receptors, Histamine H2; D004316:Doxepin; D002927:Cimetidine