Thiamin compartment models in healthy sheep.
Adult sheep received a single intravenous injection of 35S-thiamin. Blood and urine samples were taken at short intervals for the following 180 minutes and analyzed for 35S-radioactivity. Tracer disappearance from blood followed three-exponential functions. It was shown by computer simulation of different compartment models that a serial as well as a parallel three-compartment model would adequately describe 35S-thiamin disappearance from blood whereas a cyclic arrangement of the three compartments can be excluded. Total tracer excretion rates exceeding experimentally determined urinary excretion suggest the existence of a fourth compartment with nor or extremely small tracer return during the experimental period.
D000818:Animals; D007700:Kinetics; D012756:Sheep; D013831:Thiamine / Q000378:metabolism*
D013831:Thiamine