High skin tumour initiating activity of the metabolically derived trans-3,4-dihydro-3,4-diol of the carcinogen 15,16-dihydro-11-methylcyclopenta[a]phenanthren-17-one.
Eight main metabolites of the parent carcinogen 15,16-dihydro-11-methylcyclopenta[a]phenanthrene-17-one (I) were assayed for their ability to initiate skin tumours in T.O. mice after topical application in two-stage experiments with croton oil used as the promoter. All were less active than 1 with the exception of the trans-3,4-dihydro-3,4-diol which was more than ten times as active. This diol is therefore confirmed as the proximate carcinogen, a conclusion reached previously on different evidence.
D000818:Animals; D002273:Carcinogens / Q000378:metabolism*; D006067:Gonanes / Q000378:metabolism*; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D012878:Skin Neoplasms / Q000139:chemically induced*
D002273:Carcinogens; D006067:Gonanes; C035004:3,4,15,16-tetrahydro-3,4-dihydroxy-11-methyl-17H-cyclopenta(a)phenanthren-17-one; C005765:15,16-dihydro-11-methylcyclopenta(a)phenanthren-17-one