Modification of the radiation response of mouse lung by actinomycin D: dependence on interval between radiation and drug treatments.
Actinomycin D (0.6 mg/kg, i.p.) enhances the radiation response of mouse lung. The degree of enhancement varies inversely with the interval between radiation and drug treatments. The kinetics of the loss of interaction of the drug with radiation damage is similar to that observed for "slow repair" of radiation injury to the lung.
D000818:Animals; D003609:Dactinomycin / Q000494:pharmacology*; D007928:Lethal Dose 50; D008168:Lung / Q000528:radiation effects*; D051379:Mice; D011650:Pulmonary Alveoli / Q000528:radiation effects; D011838:Radiation-Sensitizing Agents; D013997:Time Factors; D014965:X-Rays
D011838:Radiation-Sensitizing Agents; D003609:Dactinomycin