Naloxone increases the nicotine-stimulated rise of vasopressin secretion in man.
Intravenous nicotine was administered to a group of six subjects during the concurrent intravenous infusion of either the opiate antagonist naloxone, or of saline. Nicotine stimulated vasopressin secretion in all subjects. Naloxone infusion increased both the plasma vasopressin response to nicotine and the resulting rise in urine osmolality.
D000328:Adult; D001127:Arginine Vasopressin / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009270:Naloxone; D009538:Nicotine; D009994:Osmolar Concentration; D010949:Plasma; D014556:Urine
D001127:Arginine Vasopressin; D009270:Naloxone; D009538:Nicotine