Brief prenatal exposure to prednisolone adversely affects behavioral development and body weight.
Female mice were exposed prenatally via maternal injection to prednisolone. At both the 100 and 300 microgram dosages, prenatal exposure to the drug reduced birth and weaning weights and delayed the attainment of eye-opening, walking, and gripping ability. These effects were observed consequent to as few as 2 maternal injections, one on Day 12 and the other on Day 13 of gestation.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005865:Gestational Age; D008431:Maternal-Fetal Exchange; D009048:Motor Skills / Q000187:drug effects; D009115:Muridae; D011239:Prednisolone / Q000009:adverse effects*; D011247:Pregnancy
D011239:Prednisolone