Liquid membrane phenomena in haloperidol action.
Haloperidol, a surface-active neuroleptic drug, was shown to generate a liquid membrane on a supporting membrane. Transport of adrenalin, noradrenalin, dopamine, serotonin, histamine, glutamic acid, gamma-aminobutyric acid, and sodium, potassium, and calcium ions through the haloperidol liquid membrane was studied. The data indicate that the phenomenon of a liquid membrane plays a significant role in the mechanism of action of haloperidol.
D000596:Amino Acids; D001679:Biogenic Amines; D002118:Calcium; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006220:Haloperidol; D008567:Membranes, Artificial; D010539:Permeability; D011188:Potassium; D012964:Sodium; D013501:Surface-Active Agents
D000596:Amino Acids; D001679:Biogenic Amines; D008567:Membranes, Artificial; D013501:Surface-Active Agents; D012964:Sodium; D006220:Haloperidol; D011188:Potassium; D002118:Calcium