Lipids in the kidney and adrenal of squirrel, Funambulus pennanti, after sex-hormones treatment.
Interference of sex-hormones viz. testosterone and progesterone with adreno-renal lipids have been determined employing histochemical and biochemical parameters. The results show that both the hormones stimulate accumulation of triglycerides and phospholipids in the kidney and adrenal glands. It has been suggested that testosterone and progesterone manipulate an increase in the input of free fatty acids (FFA) causing triglyceride formation and inhibit mitochondrial phosphorylation. Inhibition of esterases has also been proposed as the reason for the accumulation of phospholipids. Over all results have been discussed with special reference to 1. pathological exaggeration by these hormones 2. hormonal carcinogenesis, and 3. protein and carbohydrate metabolism.
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D005260:Female; D006651:Histocytochemistry; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D050356:Lipid Metabolism; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology*; D012589:Sciuridae / Q000378:metabolism*; D013091:Spermatogenesis / Q000187:drug effects; D013268:Stimulation, Chemical; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology
D010743:Phospholipids; D013739:Testosterone; D011374:Progesterone; C028499:testosterone isobutyrate