[Chromosome aberrations and sister chromatid exchanges in a human lymphocyte culture exposed to diethylstilbestrol dipropionate].
Frequency of chromosome aberrations and sister chromatid exchanges (SCE) was studied in human lymphocyte culture treated with the synthetic nonsteroidal estrogen diethylstilbestrol-dipropionate in doses of 1.3 . 10(-7) M, 1.3 . 10(-6) M and 1.3 . 10(-5) M. Doses of 1.3 . 10(-6) M and 1.3 . 10(-5) M are shown to induce a significant increase in the chromosome aberration level mostly due to a rise in the number of polyploid cells. The same doses increase the frequency of SCE.
D000328:Adult; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003434:Crossing Over, Genetic / Q000187:drug effects*; D004054:Diethylstilbestrol / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011123:Polyploidy; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D004054:Diethylstilbestrol; C000937:diethylstilbestrol dipropionate
Khromosomnye aberratsii i sestrinskie khromatidnye obmeny v kul'ture limfotsitov cheloveka pri vozdeĭstvii diétilstil"bestrol-dipropionatom.