[Zollinger-Ellison syndrome--changes in surgical therapy. Analysis of 27 patients].
In 10 out of 27 patients with a Zollinger-Ellison syndrome a gastrin-producing tumor was removed, in 5 localized with phlebography. In the remaining 12 patients the diagnosis of a gastrinoma was based on clinical data only. The 10 patients with surgically proven gastrinoma did not differ in their fasting blood-glucose levels, rise of gastrin serum levels after administration of secretin and calcium, in acid production patterns nor in survival time from those 12 patients in whom no gastric-producing tumor had been found. 5 of the 27 patients died, 4 just after surgery. One patient died from advanced malignant disease. In three of our patients localizing diagnostic procedures and consecutive tumor-removal were feasible with the protection of H2-receptor antagonists. The trend in the treatment of ZES goes away from elective total gastrectomy towards conservative treatment with H2-receptor antagonists in view of the low morbidity and the attempt of curative treatment by tumor-removal.
D000328:Adult; D000368:Aged; D002927:Cimetidine / Q000627:therapeutic use; D005260:Female; D005743:Gastrectomy; D005755:Gastrins / Q000097:blood*; D006635:Histamine H2 Antagonists; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood / Q000601:surgery*; D015043:Zollinger-Ellison Syndrome / Q000097:blood / Q000188:drug therapy / Q000601:surgery*
D005755:Gastrins; D006635:Histamine H2 Antagonists; D002927:Cimetidine
Zollinger-Ellison-Syndrom -- Wandel in der chirurgischen Therapie. Eine Analyse von 27 Patienten.