[What the viral theory of tumor origin has contributed to oncology].
The viral theory of tumor origin has proved to be an important factor of accumulation of fresh evidence and working out new methods and approaches. The paper contains a summary of this evidence and discusses the problem of the indirect co-carcinogenic effect of tumor-inducing agents. Sometimes it is due to their activation of specific oncogenic viruses. In other cases, as the author suggests, it may be caused by the activation of potential oncogenes (protooncogenes) or normal cells. There are viral and non-viral tumors and human tumors are apparently chiefly non-viral. The author suggests that it is an endogenous disease (protooncogenes and their endogenous activators). The author considers his hypothesis (1962) on the cellular origin of oncogenes and the similarity of their transmission by viruses to microorganism transduction. A similar suggestion was made by P. Vogt and A. D. Altstein ten years later and it has been supported by some findings ever since. The viral theory cannot be regarded as the sole fundamental theory of carcinogenesis.
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000648:ultrastructure; D002472:Cell Transformation, Viral; D005786:Gene Expression Regulation; D005814:Genes, Viral; D006801:Humans; D008495:Medical Oncology; D009369:Neoplasms / Q000209:etiology; D009374:Neoplasms, Experimental / Q000209:etiology / Q000235:genetics; D009858:Oncogenic Viruses / Q000235:genetics / Q000472:pathogenicity*; D014412:Tumor Virus Infections / Q000209:etiology* / Q000235:genetics
Chto dala onkologii virusnaia teoriia proiskhozhdeniia opukholeĭ.