Metabolic effects of substrates on the isolated guinea-pig heart in relation to arrhythmias during reperfusion.
Mechanisms whereby glucose reduces the incidence of pyruvate induced reperfusion arrhythmias in isolated guinea-pig hearts have been investigated. Alterations in cytoplasmic ATP/ADP ratios, creatine phosphate and glycogen were excluded as possible mechanisms. Likewise, data are presented that appear to be at variance with the proposition that glycolytically derived ATP may play a special role in the maintenance of electrical stability. To explain the anti-arrhythmic effects of glucose in terms of this thesis it is necessary to invoke compartmentation of glycolysis. A correlation between the incidence of arrhythmias and glycolytic ATP production can only exist if the contributions to glycolytic flux from glucose and glycogen utilisation can be regarded as separate.
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000378:metabolism*; D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology; D006003:Glycogen / Q000378:metabolism; D006019:Glycolysis; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009206:Myocardium / Q000378:metabolism*; D010477:Perfusion; D011773:Pyruvates / Q000494:pharmacology
D011773:Pyruvates; D000255:Adenosine Triphosphate; D006003:Glycogen; D005947:Glucose