Mechanism of coenzyme A inhibition of dihydrofolate reductase.
1. Coenzyme A was found to inhibit bovine liver dihydrofolate reductase. 2. The CoA inhibition types of dihydrofolate reductase were competitive with respect to NADPH and noncompetitive with respect to dihydrofolate. 3. The CoA inhibition is related to the number and the site of phosphoric residue in adenine nucleotide.
D000227:Adenine Nucleotides / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D003065:Coenzyme A / Q000494:pharmacology*; D005493:Folic Acid Antagonists; D008099:Liver / Q000201:enzymology; D009243:NAD / Q000494:pharmacology; D009249:NADP / Q000494:pharmacology
D000227:Adenine Nucleotides; D005493:Folic Acid Antagonists; D009243:NAD; D009249:NADP; D003065:Coenzyme A