Gastric emptying and absorption of acetylsalicylic acid administered as enteric-coated micro-granules.
Enteric-coated and uncoated microgranules of acetylsalicylic acid (ASA), labelled with 51Cr, were administered orally to six healthy male volunteers in a cross-over study. Gastric emptying was studied using a profile scanning radiation technique. Absorption of ASA was followed by measuring the plasma concentration of salicylate. Gastric emptying both of uncoated and enteric-coated granules varied considerably between individuals, but in most cases was gradual and extended over a period of several hours. The median time until 50% and 90% were emptied from the stomach was 1 and 3-3.5 h, respectively, for both the uncoated and enteric-coated granules. The absorption of ASA from the uncoated granules occurred in parallel with the gastric emptying. However, with the enteric-coated granules, absorption was delayed for about 3 h after gastric emptying. It was concluded that the slow absorption of ASA from enteric-coated granules could be explained partly by gradual gastric emptying and partly by slow dissolution of the ASA granules in the intestine.
D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000378:metabolism*; D002214:Capsules; D003692:Delayed-Action Preparations; D005746:Gastric Emptying; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption; D008297:Male; D012459:Salicylates / Q000097:blood; D020156:Salicylic Acid
D002214:Capsules; D003692:Delayed-Action Preparations; D012459:Salicylates; D020156:Salicylic Acid; D001241:Aspirin