Torsades de pointes, a common arrhythmia, induced by medication.
Between May 1980 and April 1981 four patients were referred to one hospital with syncope or recurrent ventricular fibrillation while taking antiarrhythmic or phenothiazine drugs. In all the patients ventricular tachyarrhythmias with the characteristics of torsades de pointes were documented in association with prolonged QT intervals. With removal of the offending agent (in all the patients) supplemented by temporary overdrive pacing (in two patients) the tachyarrhythmias subsided. This study suggests that drug-induced torsades de pointes is an important clinical entity that occurs more frequently than has been suspected.
D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D004206:Disopyramide / Q000009:adverse effects; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010640:Phenothiazines / Q000009:adverse effects*; D011342:Procainamide / Q000009:adverse effects; D011802:Quinidine / Q000009:adverse effects; D013575:Syncope / Q000139:chemically induced; D014693:Ventricular Fibrillation / Q000139:chemically induced* / Q000628:therapy
D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; D004206:Disopyramide; D011802:Quinidine; D011342:Procainamide