Anticoccidial drugs: growth and performance depressing effects in young chickens.
Monensin, lasalocid, salinomycin, nicarbazin, halofuginone, or arprinocid were fed to 1-week-old male broiler chicks at recommended levels and 1.5, 2, 2.5, and 3 times the recommended level, for 3 weeks. Pair-feeding experiments also were conducted to investigate the extent that growth depression with medicated diets could be attributed to the drop in feed consumption. At the recommended level of drugs, growth and feed conversion were not significantly affected. At elevated drug levels, performance was impaired; the adverse effects of drugs became more pronounced with increasing the concentrations in the diets. Weight gain was significantly depressed at 1.5X with arprinocid, halofuginone, and salinomycin, at 1 to 2X with monensin, at 2X with lasalocid, and at 2.5X with nicarbazin. Feed conversion, however, was adversely affected by 2X with halofuginone or 2.5X with salinomycin, nicarbazin, arprinocid, monensin, or lasalocid. The results of the pair-feeding experiments with 2 to 3 times drug levels indicated that most of the growth depression with medicated diets could be attributed to reduced feed consumption, but all drugs except arprinocid caused some additional growth depression.
D000225:Adenine / Q000031:analogs & derivatives / Q000633:toxicity; D000821:Animal Feed; D000818:Animals; D001835:Body Weight; D002645:Chickens / Q000254:growth & development* / Q000378:metabolism; D003049:Coccidiostats / Q000633:toxicity*; D006128:Growth / Q000187:drug effects; D007832:Lasalocid / Q000633:toxicity; D008297:Male; D008985:Monensin / Q000633:toxicity; D009528:Nicarbazin / Q000633:toxicity; D010880:Piperidines; D011799:Quinazolines / Q000633:toxicity; D052999:Quinazolinones
D003049:Coccidiostats; D010880:Piperidines; D011799:Quinazolines; D052999:Quinazolinones; D009528:Nicarbazin; C016245:arprinocid; D008985:Monensin; D000225:Adenine; C010176:halofuginone; D007832:Lasalocid