BCG induced murine peritoneal exudate cells: cytotoxic activity against a syngeneic bladder tumor cell line.
Peritoneal exudate cells from mice after intraperitoneal injection of 10 mg. of BCG demonstrated cytolytic activity in vitro against the syngeneic bladder tumor cell line MBT-2. The cytolytic effector cells are nonadherent, nonphagocytic and trypsin resistant. Moreover these cells are cyclophosphamide and hydrocortisone sensitive. It is suggested that an NK-like cell constitutes the major, if not all the population of effector cells in this reaction.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D001202:Ascitic Fluid / Q000166:cytology / Q000276:immunology; D001500:BCG Vaccine / Q000494:pharmacology*; D002460:Cell Line; D003520:Cyclophosphamide / Q000494:pharmacology; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000502:physiology*; D008264:Macrophages / Q000502:physiology; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000276:immunology / Q000628:therapy; D001749:Urinary Bladder Neoplasms / Q000276:immunology* / Q000628:therapy
D001500:BCG Vaccine; D003520:Cyclophosphamide; D006854:Hydrocortisone