Effects of prostaglandins on thrombus formation in mesenteric arterioles of rats.
Effects of locally applied prostaglandins on platelet thrombus formation in the mesenteric arterioles of rats were studied in vivo. Prostaglandin (PG) I2 and PGE1, which were reported to be powerful inhibitors of blood platelet aggregation, prevented the thrombus formation, whereas PGE2, which was reported, in low concentrations, to enhance platelet aggregation, showed a tendency to promote the thrombus formation. PGA1, PGA2 or PGF2 alpha had no effect. PGD2 had a very weak inhibitory effect. As prostaglandins tested had no effect on the diameter of mesenteric arterioles, it is assumed that the effectiveness of PGI2 and PGE1 in preventing thrombus formation is due mainly to their powerful inhibiting effects on platelet aggregation.
D000818:Animals; D001160:Arterioles / Q000187:drug effects / Q000502:physiology; D004558:Electric Stimulation; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects / Q000502:physiology*; D010974:Platelet Aggregation / Q000187:drug effects*; D011453:Prostaglandins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
D011453:Prostaglandins