Cysteamine: a potent and specific depletor of pituitary prolactin.
Cysteamine rapidly reduces the concentration of prolactin in pituitary tissue in vivo and in vitro. The effect is dose-dependent, reversible, and cannot be accounted for by prolactin release. Cysteamine does not appear to exert its effect through dopamine receptors and does not alter lactotrope morphology, as determined by electron microscopy.
D000818:Animals; D002478:Cells, Cultured; D003543:Cysteamine / Q000494:pharmacology*; D004294:Domperidone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D008297:Male; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D011388:Prolactin / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D011954:Receptors, Dopamine / Q000502:physiology; D013134:Spiperone / Q000494:pharmacology
D011954:Receptors, Dopamine; D013134:Spiperone; D004294:Domperidone; D003543:Cysteamine; D011388:Prolactin