Minimal haemolytic effects from 0.8% chlormethiazole infusion in volunteer subjects. Chlormethiazole infusion and haemolysis.
A solution of 0.8% chlormethiazole ethanedisulphonate was infused into the antecubital vein of 14 healthy volunteers for periods ranging from 60 to 120 minutes to examine any haemolytic effects in vivo. Plasma haptoglobin and haemopexin concentrations were measured before, during and after infusion. No evidence of intravascular haemolysis of any clinical significance was found.
D000293:Adolescent; D000328:Adult; D002719:Chlormethiazole / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006242:Haptoglobins / Q000378:metabolism; D006461:Hemolysis / Q000187:drug effects*; D006466:Hemopexin / Q000378:metabolism; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D014168:Transferrin / Q000378:metabolism
D006242:Haptoglobins; D014168:Transferrin; D002719:Chlormethiazole; D006466:Hemopexin