Evidence that coal tar is a mixed inducer of microsomal drug-metabolizing enzymes.
Topical application of coal tar (U.S.P.) to neonatal rats resulted in the induction of hepatic cytosolic glutathione-S-transferase and microsomal epoxide hydrolase and aminopyrine N-demethylase activities. Analogous to the effect of the polychlorinated biphenyl Aroclor 1254, treatment of neonatal rats with coal tar resulted in a one nm shift to the blue region in the wavelength maximum of the hepatic microsomal hemoprotein cytochrome P-450. These results demonstrate that therapeutic coal tar contains both type I and type II inducers of hepatic drug-metabolizing enzymes.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001140:Aroclors / Q000494:pharmacology; D020111:Chlorodiphenyl (54% Chlorine); D003033:Coal Tar / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects; D004851:Epoxide Hydrolases / Q000378:metabolism; D005260:Female; D005982:Glutathione Transferase / Q000378:metabolism; D008748:Methylcholanthrene / Q000494:pharmacology; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D010088:Oxidoreductases / Q000096:biosynthesis*; D011247:Pregnancy; D051381:Rats; D012867:Skin / Q000201:enzymology
D001140:Aroclors; D020111:Chlorodiphenyl (54% Chlorine); D008748:Methylcholanthrene; D003033:Coal Tar; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D005982:Glutathione Transferase; D004851:Epoxide Hydrolases