[Age-associated peculiarities of microcirculation system in skeletal muscles and their role in muscle work capacity in human aging (author's transl)].
The muscle blood flow was investigated at rest (MBFR) and after physical load under ischemia conditions (maximal muscle blood flow--MMBF) in 87 practically healthy persons (45 women and 42 men) aged 20--90. The state of muscle blood flow was evaluated by means of the clearance of 133xenon injected into M. tibialis anterior. The data obtained showed a decrease of MBFR and MMBF in older people as compared with younger subjects. In realization of this phenomenon a decrease in muscle capillarisation and a reduction in reactivity of microcirculatory link of vascular system plays an increasingly greater role with aging. The reduction in muscle blood flow forms a circulatory component of the age-associated hypoxia. This fact results in a decrease of muscle blood flow and limits the functional capacity of skeletal muscle under conditions of activity.
D000328:Adult; D000368:Aged; D000375:Aging; D005260:Female; D006801:Humans; D007511:Ischemia / Q000000981:diagnostic imaging; D008297:Male; D008833:Microcirculation / Q000000981:diagnostic imaging; D008875:Middle Aged; D009119:Muscle Contraction; D009132:Muscles / Q000098:blood supply*; D010100:Oxygen / Q000097:blood; D005082:Physical Exertion; D011877:Radionuclide Imaging; D012212:Rheology; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes; D010100:Oxygen
Die alternsbesonderheiten des Systems der Mikrozirkulation in den Skelettmuskeln und ihre Rolle in der Arbeitsfähigkeit des Muskels beim Altern des Menschen.