Image processing in pathology. XII. Automated morphometry of tumour cell nuclei in hypernephroma: comparison between renal tumour and late metastases.
Changes of nineteen features of tumour cell nuclei in hypernephroma and three following late metastases were investigated by use of the automated image system. Histograms of nuclei features from primary tumours and metastases were compared. They showed objectively an increased cellular dedifferentiation during metastases. Various aspects of the capability of automated morphometry for investigation of tumours are discussed.
D000230:Adenocarcinoma / Q000473:pathology* / Q000556:secondary / Q000648:ultrastructure; D000368:Aged; D002467:Cell Nucleus / Q000648:ultrastructure*; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D010783:Photometry / Q000379:methods; D013899:Thoracic Neoplasms / Q000556:secondary / Q000648:ultrastructure; D013964:Thyroid Neoplasms / Q000556:secondary / Q000648:ultrastructure