Stimulation of thymidine incorporation in isolated rat intestinal mucosal cells by feeding an ethanol-containing liquid diet.
The effect of chronic ethanol administration on the incorporation of 3H-thymidine into DNA of isolated intestinal cells in the rat was investigated. Chronic ethanol consumption increased significantly DNA synthesis in intestinal mucosal cells. Whether this enhancement of DNA synthesis as a measure for cellular regeneration is due to the local effect of ethanol via tissue injury, to a direct stimulatory effect of ethanol on enzyme activities involved in DNA metabolism or to a change in the intestinal cell population with a shift to immature crypt cells by ethanol is not known.
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D000431:Ethanol / Q000494:pharmacology*; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013936:Thymidine / Q000378:metabolism*
D000431:Ethanol; D004247:DNA; D013936:Thymidine