Kinetics and distribution of 111Indium-labeled platelets in patients with homocystinuria.
Homocystinuria is an inborn error of metabolism involving a high incidence of thromboembolism. It sometimes improves with large doses of pyridoxine. We investigated the kinetics and distribution of 111Indoxine-labeled platelets in 11 normal volunteers and 12 patients with homocystinuria, none of whom had clinical evidence of acute thrombosis at the time of the study. Six of the patients were resistant to pyridoxine and had homocystinemia. There were no statistical differences in mean platelet-survival times between pyridoxine responders and nonresponders or between normal subjects and pyridoxine responders or nonresponders, regardless of whether a linear, exponential, or multiple-hit model was used to analyze the kinetic data. Plasma homocystine levels had no apparent effect on mean platelet-survival time. There was no abnormal accumulation of platelets in any of the patients, and the distribution of platelets in liver and spleen was similar to that in normal subjects. Our results suggest that the kinetics and distribution of platelets in patients with homocystinuria who have no clinical evidence of thromboembolism are normal. Thus, the data do not provide evidence for disordered platelet function or for an ongoing interaction of platelets with vessel walls in this condition.
D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D006711:Homocystine / Q000097:blood; D006712:Homocystinuria / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007204:Indium; D007700:Kinetics; D008875:Middle Aged; D011736:Pyridoxine / Q000627:therapeutic use; D011868:Radioisotopes; D013923:Thromboembolism / Q000517:prevention & control
D011868:Radioisotopes; D007204:Indium; D006711:Homocystine; D011736:Pyridoxine