Role of adrenal medulla in morphine-induced hyperthermia through central action.
The role of the adrenal glands, in morphine-induced hyperthermia was studied in normal, chemically-sympathectomized, adrenalectomized, adrenal-demedullated or splanchnicotomized rats. 2. In restrained female rats, 5 mg/kg morphine produced hyperthermia whereas 20 mg/kg and 40 mg/kg produced hyperthermia. 3. After adrenalectomy, 5 mg/kg morphine did not produce hyperthermia. 4. After adrenal-demedullation or adrenal-denervation (splanchnicotomy), 5 mg/kg morphine did not produce hyperthermia. 5. The results suggest that, in the rat, the adrenal medulla plays an important role in morphine-induced hyperthermia, and that morphine acts centrally to stimulate the medulla.
D000313:Adrenal Medulla / Q000294:innervation / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D003714:Denervation; D004347:Drug Interactions; D005260:Female; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013563:Sympathectomy, Chemical; D013997:Time Factors
D009020:Morphine