Polyamines and globin binding in sickle cell disease.
Erythrocytes obtained from patients with sickle cell anemia contain five to ten times more spermine than controls. The preferential binding of beta s globin to red cell stroma may be mediated by spermine and may account in part for the membrane abnormalities found in sickle cell disorders.
D000755:Anemia, Sickle Cell / Q000097:blood*; D004912:Erythrocytes / Q000032:analysis; D006441:Hemoglobin A / Q000378:metabolism*; D006451:Hemoglobin, Sickle / Q000378:metabolism*; D006801:Humans; D011073:Polyamines / Q000097:blood*; D011485:Protein Binding; D013096:Spermine / Q000097:blood
D006451:Hemoglobin, Sickle; D011073:Polyamines; D013096:Spermine; C028672:hemoglobin AA; D006441:Hemoglobin A