Body fluid concentrations of ampicillin trihydrate in 6 horses after a single intramuscular dose.
Six adult mares were given a single dose of ampicillin trihydrate (250 mg/ml) intramuscularly at a dosage of 20 mg/kg body weight. Serum, synovial fluid, peritoneal fluid and urine ampicillin concentrations were measured serially over a 48 h period. The mean peak serum ampicillin concentration was 2.49 micrograms/ml at 6 h. Ampicillin was found in synovial fluid and peritoneal fluid, which obtained mean peak ampicillin concentrations of 1.65 micrograms/ml and 1.81 micrograms/ml at 6 h and 4 h respectively. These concentrations declined in parallel with serum concentrations and were still detectable at 48 h. Urine concentration of ampicillin was relatively high, with a mean peak concentration of 1364.9 micrograms/ml at 4 h.
D000667:Ampicillin / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D001202:Ascitic Fluid / Q000378:metabolism; D001826:Body Fluids / Q000378:metabolism*; D005260:Female; D006736:Horses / Q000378:metabolism*; D007273:Injections, Intramuscular / Q000662:veterinary; D013582:Synovial Fluid / Q000378:metabolism; D014556:Urine / Q000378:metabolism
D000667:Ampicillin