Influence of clonazepam and ethosuximide on ECoG pattern induced by metrazol during ontogenesis in rats.
Metrazol (80 mg/kg s. c.) elicited ECoG episodes of rhythmic activity the shape, frequency and localization of which depended on the age of rats. In 15- and 12-day-old animals there was a progression into sustained ictal activity. Clonazepam (1 mg/kg i. p.) exhibited excellent anti-metrazol action in adult, 25- and 12-day-old rats. The results in 15-day-old animals were inconsistent. Ethosuximide (125 mg/kg i. p.) protected sufficiently only adult and 25-day-old rats. In younger age groups only ictal activity was blocked, while metrazol-induced episodes remained untouched.
D000367:Age Factors; D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects*; D002998:Clonazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D005013:Ethosuximide / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D008297:Male; D010433:Pentylenetetrazole / Q000633:toxicity*; D051381:Rats; D012640:Seizures / Q000139:chemically induced*
D001570:Benzodiazepinones; D002998:Clonazepam; D005013:Ethosuximide; D010433:Pentylenetetrazole