Further characterization of the molecular species formed during the biosynthesis of rat luteinizing hormone.
During the biosynthesis of rat LH (rLH) there are four molecular species found intracellularly: native rLH, a species which co-elutes with rLHalpha on Sephadex G-100, a species which elutes with an apparent molecular weight of approximately 21 000 and a large molecular weight form (excluded from Sephadex G-100). Significant quantities of native rLH and rLHalpha are secreted. The species of large molecular weight binds to Concanavalin A-Sepharose suggesting that it is glycosylated. The 21 000 molecular weight rLH-like molecule has tentatively been identified as an rLH subunit which has not been completely processed.
D000818:Animals; D001681:Biological Assay; D055598:Chemical Phenomena; D002621:Chemistry; D002846:Chromatography, Affinity; D002850:Chromatography, Gel; D066298:In Vitro Techniques; D007986:Luteinizing Hormone / Q000096:biosynthesis* / Q000378:metabolism; D008297:Male; D008970:Molecular Weight; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains
D007986:Luteinizing Hormone