Tryptophan metabolism by a papaverine-degrading Nocardia sp.
Tryptophan catabolism was studied in a papaverine-degrading Nocardia sp. L-Tryptophan degradation follows the quinoline route via kynurenic acid. 5-(2-Carboxyethyl)-4,6-dihydroxypicolinic acid was isolated as a kynurenic acid metabolite. Mutants were induced with N-methyl-N'-nitro-N-nitrosoguanidine. A mutant was isolated, which accumulated 5-hydroxyanthranilic acid. There is no relationship between kynurenic acid degradation and papaverine degradation. All kynurenic acid mutants were able to use papaverine as a carbon source and all papaverine mutants could be grown at the expense of kynurenic acid.
D007700:Kinetics; D007736:Kynurenic Acid / Q000378:metabolism; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D009154:Mutation; D009615:Nocardia / Q000187:drug effects / Q000378:metabolism*; D010208:Papaverine / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism*
D008769:Methylnitronitrosoguanidine; D014364:Tryptophan; D010208:Papaverine; D007736:Kynurenic Acid