Partial characterization of a fibrinolytic inhibitor produced by cultured endothelial cells derived from human umbilical vein.
A preliminary characterization of a fibrinolytic inhibitor released by human umbilical vein endothelial cells in primary culture is reported. This molecule of Mr comprised between 2 X 10(5) and 10(6) and of alpha 2 mobility precipitates at 43% ammonium sulphate saturation and is totally adsorbed on Concanavalin A Sepharose 4 B. A possible relationship with alpha macroglobulins is discussed.
D000933:Antifibrinolytic Agents / Q000032:analysis / Q000302:isolation & purification*; D002478:Cells, Cultured; D004727:Endothelium / Q000378:metabolism; D006801:Humans; D014471:Umbilical Veins / Q000378:metabolism*
D000933:Antifibrinolytic Agents