[Phenols, other components of oil share tars and asbestos as factors of modifying the action of benzo(a)-pyrene (author's transl)].
Skin painting experiments in mice revealed the promoting action of various shale oil chromatographic fractions on a threshold dose of benzo(a)pyrene. The fractions containing phenols and neutral oxygen compounds showed a moderate activity. Simultaneous intratracheal administration of benzo(a)pyrene, shale oil phenols and asbestos dust caused the highest lung tumour incidence in rats. Asbestos dust potentiated the carcinogenic action of benzo(a)pyrene to the same extent as shale oil phenols, whereas the latter did not have any such influence on the asbestos dust.
D000818:Animals; D001194:Asbestos / Q000494:pharmacology*; D001580:Benzopyrenes / Q000494:pharmacology*; D002273:Carcinogens; D004357:Drug Synergism; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D010578:Petroleum; D010636:Phenols / Q000494:pharmacology*; D051381:Rats; D013638:Tars / Q000494:pharmacology*
D001580:Benzopyrenes; D002273:Carcinogens; D010578:Petroleum; D010636:Phenols; D013638:Tars; D001194:Asbestos
Phenole, andere Bestandteile des Brennschieferters und Asbest als modifizierende Faktoren der karzinogenen Wirkung von Benzo(a)pyren.