[Pituitary gland extract insufflation lung].
In two patients with diabetes insipidus the development of an allergic alveolitis with transition into pulmonary fibrosis could be observed. The alveolitis is evoked by snuffing of posterior pituitary extracts. The pathomechanism of this side effect (disease) is similar to those of other allergic alveolitides (e.g. farmer's lung, bird-fancier's lung, malt-worker's lung etc). This disease can be avoided by changing the therapy of diabetes insipidus to fully synthetic preparations free of protein. When irreversible changes are already present at the stroma of the lung (X-ray picture, function of the lung, histology), then the therapeutic possibilities are restricted and the prognosis is unfavourable.
D000281:Administration, Intranasal; D000328:Adult; D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced*; D003919:Diabetes Insipidus / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008236:Lypressin / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010909:Pituitary Hormones, Posterior / Q000009:adverse effects*; D011658:Pulmonary Fibrosis / Q000139:chemically induced*
D010909:Pituitary Hormones, Posterior; C034819:hypostin; D008236:Lypressin
Hypophysenextraktschnupferlunge.