[Contribution to the stability of tropicamide solutions (author's transl)].
The course of the degradation of tropicamide solutions was elucidated. Thus, inter alia, intramolecular elimination of water leads to a compound comparable to apoatropine that the authors designated by atropicamide. Furthermore, methods are described that permit (after thin-layer chromatographic repartition) to detect and to determine quantitatively the active principle in the presence of its degradation products. Tropicamide is stable in aqueous solution; eye-drops prepared from such a solution (Mydrum) are stable for no less than 5 years.
D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D009883:Ophthalmic Solutions / Q000032:analysis; D011725:Pyridines / Q000032:analysis; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D014331:Tropicamide / Q000032:analysis
D009883:Ophthalmic Solutions; D011725:Pyridines; D012996:Solutions; D014331:Tropicamide
Beitrag zur Stabilität von Tropicamidlösungen.