Studies of a human mesothelioma.
Abdominal fluid from a patient with mesothelioma was cultured in vitro, and a cell line designated JMN was established. This cell line has undergone more than 100 passages. Electron microscopic, karyotypic, and heterotransplantation studies as well as the capability of collagen synthesis by this cell line indicated that it is of malignant mesothelial origin. The cell line has proved very useful for the isolation of human pathogenic viruses.
D000008:Abdominal Neoplasms / Q000032:analysis / Q000473:pathology*; D000818:Animals; D001826:Body Fluids / Q000032:analysis / Q000166:cytology; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008654:Mesothelioma / Q000032:analysis / Q000473:pathology*; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009368:Neoplasm Transplantation