[14C]erythritol clearance and canalicular bile acid-independent flow in the baboon.
The use of [14C]erythritol for the quantitative assessment of hepatic bile formation has been studied in baboons using sodium taurocholate to generate canalicular bile flow. It has been found that increments in [14C]erythritol clearance are equal to taurocholate-induced increments in bile flow, but there was no change in [14C]erythritol clearance when bile flow was increased by secretin. No evidence was found to support the view that bile acids affect bile acid-independent bile flow.
D000818:Animals; D001647:Bile Acids and Salts / Q000502:physiology*; D001648:Bile Canaliculi / Q000502:physiology*; D001653:Bile Ducts, Intrahepatic / Q000502:physiology*; D002250:Carbon Radioisotopes; D004896:Erythritol / Q000378:metabolism*; D005260:Female; D008657:Metabolic Clearance Rate; D010215:Papio / Q000502:physiology*; D012633:Secretin / Q000494:pharmacology; D013656:Taurocholic Acid / Q000494:pharmacology
D001647:Bile Acids and Salts; D002250:Carbon Radioisotopes; D012633:Secretin; D013656:Taurocholic Acid; D004896:Erythritol