Bladder urothelium in analgesic-associated nephropathy--a valuable diagnostic aid.
A brownish discoloration of the bladder mucosa on cystoscopy and the histological findings in a bladder biopsy specimen of submucosal vascular basement membrane thickening, pigment or chronic inflammatory changes in the absence of infection were present in various combinations in all our patients with analgesic-associated nephropathy. None of these findings was present in a control group of patients with other established causes of renal function impairment. More objective diagnostic aids may lead to a greater awareness and earlier diagnosis of this preventable cause of chronic renal failure.
D000328:Adult; D000700:Analgesics / Q000009:adverse effects*; D001485:Basement Membrane / Q000473:pathology; D001706:Biopsy; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D001743:Urinary Bladder / Q000473:pathology*
D000700:Analgesics