[Immunogenicity study of netilmicin (author's transl)].
Immunogenicity of netilmicin (NTL) was studied and following results were obtained. The antisera obtained from rabbits immunized with both NTL alone and NTL . HSA mixture did not show positive response in the heterologous 3-hour PCA reaction and the passive hemagglutination test against the challenge of either NTL alone of NTL . OVA mixture. Guinea pigs immunized with NTL alone did not exhibit systemic anaphylaxis when elicited with NTL alone. The antisera obtained from BALB/c mice immunized with NTL-OVA conjugate adsorbed to A1(OH)3 gel gave positive response in the 24-hour PCA reaction by the method described by MOTA, whereas did not respond to intact NTL in the same system. Similar responses were also obtained in the animals immunized with either gentamicin or gentamicin.protein mixture used as control.
D000818:Animals; D000941:Antigens / Q000276:immunology*; D005260:Female; D005839:Gentamicins / Q000276:immunology*; D006168:Guinea Pigs; D006386:Hemagglutination Tests; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009428:Netilmicin / Q000276:immunology*; D010047:Ovalbumin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000276:immunology
D000941:Antigens; D005839:Gentamicins; D007074:Immunoglobulin G; D012709:Serum Albumin; D007073:Immunoglobulin E; D009428:Netilmicin; D010047:Ovalbumin