Antipyrine clearance, aminopyrine N-demethylase, and bilirubin UDP-glucuronyl transferase activity in patients with amoebic liver abscess.
Three indices of drug metabolism, antipyrine clearance in vivo, and aminopyrine N-demethylase and bilirubin UDP-glucuronyl transferase activity in liver biopsies, were studied in fifteen patients with amoebic liver abscess (with and without jaundice). The mean (+/- S.E.) antipyrine half-life in patients with jaundice was 21.64 (+/- 1.52) h and in patients without jaundice was 19.36 (+/- 0.93) h. It was significantly prolonged in both groups of patients as compared to controls (11.63 +/- 0.86 h). It showed a good correlation with serum albumin (p less than 0.01), prothrombin time index (p less than 0.01), and aminopyrine N-demethylase (p less than 0.05). Aminopyrine N-demethylase was found to be decreased in patients without jaundice but no significant change could be observed in patients with jaundice. Bilirubin UDP-glucuronyl transferase showed no significant change in either of the groups.
D000293:Adolescent; D000328:Adult; D000633:Aminopyrine N-Demethylase / Q000378:metabolism*; D000983:Antipyrine / Q000378:metabolism*; D005260:Female; D014453:Glucuronosyltransferase; D006207:Half-Life; D006602:Hexosyltransferases / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008101:Liver Abscess, Amebic / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged
C019787:bilirubin glucuronoside glucuronosyltransferase; D000633:Aminopyrine N-Demethylase; D006602:Hexosyltransferases; D014453:Glucuronosyltransferase; D000983:Antipyrine