[Action of enkephalins and their analogs on gastric secretion].
The gastric secretion induced by histamine increased under the influence of enkephalin analog Tyr--D--Ala--Gly--Phe(NO2)NH2. The enkephalin analog Tyr--Gly--Gly--Phe--Leu--D--Arg increased the amount of gastric juice and pepsin, but the debit of hydrochloric acid was lower than in perfusion of histamine alone. Another analog of enkephalin Tyr--D--Ala--Gly--Phe--D--Leu--Arg administered together with histamine decreased the gastric juice secretion only within 90--105 min after the beginning of the perfusion.
D000818:Animals; D004285:Dogs; D004347:Drug Interactions; D004723:Endorphins / Q000494:pharmacology*; D004745:Enkephalins / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology; D010418:Pentagastrin / Q000494:pharmacology; D013997:Time Factors
D004723:Endorphins; D004745:Enkephalins; D006632:Histamine; D010418:Pentagastrin
Deĭstvie énkefalinov i ikh analogov na zheludochnuiu sekretsiiu.