Clinical fascioliasis in domestic goats in Montana.
Fascioliasis (Fasciola hepatica infection) was diagnosed in a herd of domestic goats in Montana. Twenty-eight goats died after a month-long clinical course of anorexia, weight loss, depression, lethargy, and decreased milk production. Clinical laboratory findings included anemia, low hemoglobin content, hypoproteinemia, hypoalbuminemia, eosinophilia, and high hepatic enzyme activity. The livers of affected goats had extensive parenchymal necrosis, fibrosis, and biliary hyperplasia. Albendazole oral suspension (20 mg/kg) was used to treat 45 of the remaining goats twice, 30 days apart; 15 goats were untreated controls. Egg counts for the untreated group averaged 171 fluke eggs per gram of feces, which compared with less than 1 epg per gram for the treated group. Fifteen percent of the treated goats died, whereas 73% of the untreated goats died. On the basis of necropsy findings, albendazole treatment was regarded as greater than 99% effective against adult F hepatica.
D015766:Albendazole; D000740:Anemia / Q000209:etiology / Q000662:veterinary; D000818:Animals; D000829:Animals, Domestic; D000871:Anthelmintics / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D001798:Blood Proteins / Q000032:analysis; D004196:Disease Outbreaks / Q000662:veterinary*; D005210:Fasciola hepatica / Q000302:isolation & purification; D005211:Fascioliasis / Q000150:complications / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D005260:Female; D006041:Goats; D008297:Male
D000871:Anthelmintics; D001562:Benzimidazoles; D001798:Blood Proteins; D015766:Albendazole