Pharmacological properties of Dibenzo[a,c]cyclooctene derivatives isolated from Fructus Schizandrae Chinensis III. Inhibitory effects on carbon tetrachloride-induced lipid peroxidation, metabolism and covalent binding of carbon tetrachloride to lipids.
Fructus Schizandrae, a traditional Chinese tonic, has been shown to lower the elevated serum glutamic pyruvic transaminase (SGPT) levels of patients with chronic viral hepatitis and several of its components decrease the hepatotoxicity of carbon tetrachloride (CCl4) in animals. This paper deals with the mechanism of protection against CCl4-hepatotoxicity of these compounds as well as of DDB, a synthetic analogue of Schizandrin (Sin) C. Of the seven components, Sin B and C, Schizandrol (Sol) B, Schizandrer (Ser) A and B, as well as dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxy-biphenyl-2,2'-dicarboxylate (DDB) were shown to inhibit CCl4-induced lipid peroxidation and [14C]Cl4 covalent binding to lipids of liver microsomes from phenobarbital(PB)-treated mice. The compounds also decreased carbon monoxide (CO) production and cofactor (NADPH, oxygen) utilization during CCl4 metabolization by liver microsomes. It may be postulated, therefore, that the hepatoprotective effect of certain components isolated from Fructus Schizandrae as well as DDB is due to their inhibitory effect on CCl4-induced lipid peroxidation and the binding of CCl4-metabolites to lipids of liver microsomes.
D000818:Animals; D002251:Carbon Tetrachloride / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002681:China; D034242:Cyclooctanes; D004149:Dioxoles / Q000494:pharmacology*; D017705:Lignans; D050356:Lipid Metabolism; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000494:pharmacology*
D034242:Cyclooctanes; D004149:Dioxoles; D017705:Lignans; D008054:Lipid Peroxides; D011083:Polycyclic Compounds; C015499:schizandrin B; D009249:NADP; C033585:schizandrol B; C082090:schisantherin B; C034557:schizandrer A; C031409:schizandrin C; D002251:Carbon Tetrachloride; C011105:schizandrin