[Effect of monovalent cations on calcium transport in the mitochondria].
Radioisotope exchange was used to study the effect of the Na+/K+ ratio on Ca2+ absorption and release from mitochondria of the rat myocardium, brain and fatty tissue. The increase in Na+ concentration in the incubation medium containing ATP and succinate leads to a 8-fold reduction of the Ca-accumulating capacity of brain mitochondria (K0,5 for Na+ 7 and 30 mM, respectively). A mechanism is suggested that explains the possibility of the Na-dependent regulation of the Ca-accumulating capacity of mitochondria of the tissues under consideration.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D002414:Cations, Monovalent / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000494:pharmacology*
D002414:Cations, Monovalent; D012964:Sodium; D011188:Potassium; D002118:Calcium
O vliianii odnovalentnykh kationov na transport kal'tsiia v mitokhondriiakh.