[Effectiveness of humoral and cellular protective factors in experimental influenza].
The results of application of a new experimental approach proposed by A. A. Smorodintsev in investigations of a comparative defensive role of cellular and humoral factors of influenza immunity in the phenomena of recovery are presented. A more marked effect on the processes of recovery of cellular defence factors in infected mice than those of the sera of the same animal donors was observed. The effectiveness of the action of the cellular factors of immunity on the development of experimental influenza infection depended on the duration of the viral process to a lesser extent than the effect of homologous antibodies. The protective activity of lymphocytes and macrophages of inflammatory exudates was particularly high when the cells obtained early after immunization (4-5 days) were used.
D000818:Animals; D000917:Antibody Formation; D007106:Immune Sera / Q000302:isolation & purification; D007111:Immunity, Cellular; D007116:Immunization, Passive / Q000379:methods; D051379:Mice; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000628:therapy; D013997:Time Factors
D007106:Immune Sera
Effektivnost' gumoral'nykh i kletochnykh zashchitnykh faktorov pri éksperimental'noĭ grippoznoĭ infektsii.