[Antibiotic formation from a pyrimidine base group and an aminoglycoside group by a Streptomyces coeruleoaurantiacus sp. nov. culture].
An actinomycete strain 4009 was isolated from a soil sample collected in Volgograd. The strain showed a broad antibacterial spectrum. It produced antibiotics belonging to 2 different groups of chemical compounds, i.e. amycetin from the group of pyrimidine bases and nebramycin from the group of aminoglycosides. The antibiotic-producing organism is described as a type strain of Streptomyces coeruleoaurantiacus sp. nov. The new species is characterized by spiral spore chains, wart-like spore surface, blue aerial mycelium and dark yellow, orange-yellow or brown-orange-yellow substrate mycelium, the absence of soluble pigments on synthetic media and secretion of melanin pigments on the Tresner medium. Various conditions for submerged production of the antibiotic were studied.
D000617:Aminoglycosides / Q000096:biosynthesis; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D003470:Culture Media / Q000378:metabolism; D009328:Nebramycin / Q000096:biosynthesis*; D011741:Pyrimidine Nucleosides / Q000096:biosynthesis*; D011743:Pyrimidines / Q000096:biosynthesis; D012988:Soil Microbiology; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003470:Culture Media; D011741:Pyrimidine Nucleosides; D011743:Pyrimidines; C004413:amicetin; D009328:Nebramycin
Obrazovanie antibiotikov iz gruppy pirimidinovykh osnovaniĭ i gruppy aminoglikozidov kul'turoĭ Streptomyces coeruleoaurantiacus sp. nov.