Bronchodilator potential of nifedipine in vitro.
To assess the potential impact of nifedipine in asthma the effects on histamine- and metacholine-induced contractions in guinea-pig tracheal muscle were studied. Nifedipine is a physiological antagonist of these substances, but also appears to antagonize isoprenaline-induced relaxation. Further studies will be necessary to define the precise implications of these observations.
D000818:Animals; D001993:Bronchodilator Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000494:pharmacology*; D007545:Isoproterenol / Q000037:antagonists & inhibitors*; D009119:Muscle Contraction / Q000187:drug effects; D009543:Nifedipine / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects*
D001993:Bronchodilator Agents; D006633:Histamine Antagonists; D011725:Pyridines; D009543:Nifedipine; D007545:Isoproterenol