Estrogen and progestin receptors in intracranial meningiomas.
Tissue samples from 16 meningioma patients were analysed for the cytosolic estrogen receptor concentration using isoelectric focusing and 11 of the 16 cases were also analysed for the cytosolic progestin receptor concentration using sucrose gradient centrifugation. In this study, 15 of the 16 (94%) and 9 of the 11 (82%) meningiomas had detectable estrogen and progestin receptors, respectively. The mean estrogen receptor concentration in female subjects was 8.9 fmol/mg protein and in males 3.0 fmol/mg protein. This sexual difference in receptor content was statistically significant. When the progestin receptor concentrations were plotted against the estrogen receptor concentrations in the same tumors, a relatively good positive correlation was obtained in female patients (r = 0.87). These findings confirm and extend previous reports on the existence of sex steroid receptors in human brain tumors and might open up the possibility of selective endocrine therapy against meningiomas, especially in case of poor-risk patients.
D000328:Adult; D000368:Aged; D003600:Cytosol / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000378:metabolism*; D008579:Meningioma / Q000378:metabolism*; D008875:Middle Aged; D011372:Progestins / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D012737:Sex Factors; D013329:Structure-Activity Relationship
D004967:Estrogens; D011372:Progestins; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone