[Electrocardiographic evaluation of the cardiotoxicity of N-methylglucamine antimonate (R glucantime)].
The heart toxicity of N-Methyl-glucamine antimoniate (R glucantime) was studied by electrocardiographic readings in 16 patients with acute cutaneous Leishmaniasis. All patients studied came from the town of Tovar and it's surrounding areas, in the district of Tovar, Merida State, Venezuela. A dosage of 25 to 50 mg/kg/day of N-Methyl-glucamine in two or three treatment series, produced the healing of the cutaneous sore, without electrocardiographic alterations which could be interpreted as signs of myocardial toxicity.
D000293:Adolescent; D000328:Adult; D000965:Antimony / Q000009:adverse effects* / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D002648:Child; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects*; D006329:Heart Conduction System / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007896:Leishmaniasis / Q000188:drug therapy*; D008297:Male; D008536:Meglumine; D000077485:Meglumine Antimoniate; D008875:Middle Aged; D009942:Organometallic Compounds
D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate; D000965:Antimony
Valoración electrocardiográfica de la cardiotoxicidad del antimoniato de N-metil glucamina (R glucantime).