Cerebrospinal fluid and blood thiamine concentrations in phenytoin-treated epileptics.
Thiamine and folate levels in blood and cerebrospinal fluid (CSF) were determined by microbiological assays in 23 control subjects and 11 phenytoin-treated epileptics. There was no significant difference between the two groups for serum and CSF folate levels. There was, however, a statistically significant difference between the groups for both whole blood thiamine and CSF thiamine levels. Epileptic patients being treated with phenytoin had lower values than control subjects.
D004827:Epilepsy / Q000097:blood / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D005492:Folic Acid / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D008875:Middle Aged; D010672:Phenytoin / Q000627:therapeutic use*; D013831:Thiamine / Q000097:blood / Q000134:cerebrospinal fluid*
D010672:Phenytoin; D005492:Folic Acid; D013831:Thiamine