Tumor-promoting phorbol esters and mezerien induce contraction in hydra.
12-O-tetradecanoyl phorbol-13-acetate (TPA, 1-100 ng/ml) induced a reversible contraction in the hydra, Hydra japonica. Another tumor-promoting phorbol ester, phorbol-12, 13-didecanoate (PDD), and mezerein also induced contraction, but non-tumor-promoting derivatives such as 4alpha-PDD and phorbol did not.
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D004224:Diterpenes; D006829:Hydra / Q000187:drug effects / Q000502:physiology*; D010703:Phorbol Esters / Q000494:pharmacology*; D010704:Phorbols / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013729:Terpenes; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010703:Phorbol Esters; D010704:Phorbols; D013729:Terpenes; C011309:mezerein; D013755:Tetradecanoylphorbol Acetate