Taurine and hyperexcitable human muscle: effects of taurine on potassium-induced hyperexcitability of dystrophic myotonic and normal muscles.
Progressively increasing concentrations of potassium chloride in Evans blue saline were administered to patients affected with myotonic dystrophy and to healthy volunteers before and after parenteral treatment with taurine. Excitability changes of thenar eminence muscles were related to the venous potassium and chloride concentrations. The actual electrolyte concentrations were compared to those to be expected if no infused electrolytes had been transported into cells. The expected concentrations were calculated by means of Evans blue dilution. This method permitted quantification of changes of muscle-excitability in terms of the potassium chloride concentration capable of disturbing the electrical activity of the studied muscles. The method also provided an indirect evaluation of electrolyte movements across muscle membrane in vivo in humans. Dystrophic myotonic muscles appeared highly sensitive to extracellular potassium and, unlike normal muscles, were unable to accumulate potassium-induced muscle hyperexcitability and favored electrolyte accumulation in dystrophic myotonic muscles. The stabilizing effect of taurine is discussed in relation to its ability to increase intracellular potassium concentration, membrane conductance, or both.
D000293:Adolescent; D000328:Adult; D002463:Cell Membrane Permeability; D004553:Electric Conductivity; D005260:Female; D006801:Humans; D008297:Male; D009132:Muscles / Q000378:metabolism / Q000503:physiopathology*; D009223:Myotonic Dystrophy / Q000188:drug therapy* / Q000503:physiopathology; D011189:Potassium Chloride / Q000378:metabolism; D012508:Sarcolemma / Q000502:physiology; D013654:Taurine / Q000627:therapeutic use*
D013654:Taurine; D011189:Potassium Chloride