Lymphocytes induce resorption of cartilage by producing catabolin.
Mononuclear cells from pig blood, when cultured in the presence of lectins (concanavalin A or phytohaemagglutinin), release a factor that induces resorption of proteoglycan in explants of live bovine nasal cartilage. The factor had mol.wt. 20000 and pI 4.6-5.0, and was indistinguishable from the cartilage-catabolic protein catabolin isolated from culture medium of explants of pig synovial tissue. Since much of the catabolin from the mononuclear cells arose from the non-adherent population (98% lymphocytes) it was concluded that lymphocytes (and possibly monocytes) make catabolin.
D000818:Animals; D001798:Blood Proteins; D002356:Cartilage / Q000187:drug effects / Q000378:metabolism*; D002478:Cells, Cultured; D006854:Hydrocortisone / Q000494:pharmacology; D007375:Interleukin-1; D053583:Interleukin-1beta; D008214:Lymphocytes / Q000378:metabolism*; D011506:Proteins / Q000494:pharmacology; D011509:Proteoglycans / Q000378:metabolism; D013552:Swine
D001798:Blood Proteins; D007375:Interleukin-1; D053583:Interleukin-1beta; D011506:Proteins; D011509:Proteoglycans; D006854:Hydrocortisone