Deposition of small 99mTc-labelled colloids in bone marrow and lymph nodes.
The degree of deposition of small-particle colloids such as 99mTc-antimony sulfide colloids (ASC-group) and 99mTc-rhenium colloid (Tc-Re) in the bone marrow and lymph node was studied. H-ASC that was prepared in our laboratory was concentrated to a higher degree both in the bone marrow and lymph nodes, compared with other colloids. The H-ASC were mostly from 5 to 12.5 nm and the shape was uniform and spherical. The degree of deposition of Tc-Re in rabbit lymph nodes was not higher, however, the label was considered to be valuable clinically. The degree of deposition of Tc-Re in the bone marrow was not satisfactory. The size of Tc-Re was much smaller than H-ASC, ranging from 3 to 5 nm. From these results, it is considered that factors affecting deposition in the marrow are not identical to those in the lymph nodes.
D000818:Animals; D000965:Antimony / Q000378:metabolism*; D001853:Bone Marrow / Q000032:analysis / Q000000981:diagnostic imaging*; D008198:Lymph Nodes / Q000032:analysis / Q000000981:diagnostic imaging*; D008854:Microscopy, Electron; D010316:Particle Size; D011817:Rabbits; D011877:Radionuclide Imaging; D012211:Rhenium / Q000378:metabolism*; D013455:Sulfur / Q000378:metabolism; D013667:Technetium / Q000378:metabolism*; D017556:Technetium Compounds; D013671:Technetium Tc 99m Sulfur Colloid; D014018:Tissue Distribution
D017556:Technetium Compounds; C019096:technetium Tc 99m antimony sulfide; C030576:technetium Tc 99m rhenium colloid; D013671:Technetium Tc 99m Sulfur Colloid; D013455:Sulfur; D012211:Rhenium; D013667:Technetium; D000965:Antimony