[Differentiation of hepatocytes and cholangiocytes in the embryonal and postnatal periods of rat ontogenesis].
The liver of the rat embryos (10-12 days of development) of 1- and 2-week-old rats and of immature and mature rats has been studied by means of a complex of histological, cyto- and enzymohistochemical, electron microscopic and morphometric methods. In the process of the hepatic histogenesis, a divergent differentiation of cells of the hepato- and cholangioblastic differons takes place. The cells of the hepatoblastic differon by thier morpho- and cytofunctional peculiarities, sharply differ from the elements of the cholangioblastic series. The divergent differentiation already begins at the stage of the hepatic anlage, is stable and irreversible, since between the cells of various differons there are no intermediate forms at all stages of histogenesis. The presence of the two stably determinated differons in the epithelial cells explains the difference of histoblastic potencies in the glandular parenchyma and in the epithelium of the intrahepatic ducts. Histogenetic regularities of differentiation should be taken into account when analysing various reactive an pathological changes in the mammalian liver, since they are the incontrovertible arguments against a possible transformation of the hepatic beams into the bile ducts and vice versa.
D000818:Animals; D001653:Bile Ducts, Intrahepatic / Q000166:cytology / Q000196:embryology* / Q000254:growth & development; D002454:Cell Differentiation; D008099:Liver / Q000166:cytology / Q000196:embryology* / Q000254:growth & development; D051381:Rats
Differentsirovka gepatotsitov i kholangiotsitov v émbrional'nom i postnatal'nom periodakh ontogeneza krys.