Chelation in metal intoxication X: Influence of different polyaminocarboxylic acids and thiol chelators in the excretion and tissue distribution of 54Mn in rat.
The influence of some selected polyaminocarboxylic acids and thiol metal binding agents on the urinary and faecal excretions of 54Mn and on the tissue distribution of 54Mn in 54MnCl2 administered rats was studied to find a suitable chelating drug for Mn poisoning. HEDTA, CDTA, DTPA and TTHA were highly successful in enhancing the excretion of 54Mn and reducing the tissue levels of 54Mn in rats. The thiol chelators viz. D L-penicillamine, N-acetyl D L-penicillamine and DMS could neither influence the excretion nor the tissue distribution of 54Mn suggesting poor affinity of the metal towards sulfhydryl groups.
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D002614:Chelating Agents / Q000494:pharmacology*; D005243:Feces / Q000032:analysis; D008297:Male; D008345:Manganese / Q000378:metabolism*; D011073:Polyamines / Q000494:pharmacology; D011868:Radioisotopes; D051381:Rats; D013438:Sulfhydryl Compounds / Q000378:metabolism; D014018:Tissue Distribution
D000596:Amino Acids; D002614:Chelating Agents; D011073:Polyamines; D011868:Radioisotopes; D013438:Sulfhydryl Compounds; D008345:Manganese