[Determination of the effect of furanthril on myocardial infarct lesion size according to precordial electrocardiogram (mapping) and enzyme activity findings].
The ECG Mapping from 30 precordial points in 56 patients with recent anterior transmural infarctions was followed up as well as the level of the enzymes, acid phosphokinase, SGOT and LDH-iso during the first 6 days after the origination of the cardiac infarction. Thirty six patients were treated according to the generally adopted treatment schedule of cardiac infarction (group without furanthril) and 20 patients were administered, in addition to the generally adopted schedule, one tablet furanthril daily during the first six days (group with furanthril. Though no manifested discrepancies were observed in the indices studied in both groups (without and with furanthril)--in patients administered furanthril systematically--a better manifested drop was found in ECG Mapping indices and the enzyme activity in the course of the cardiac infarction, as compared with the group without furanthril. In some of the cases that tendency was with a statistical significance. According to clinical data, extensive lesion of myocardium and cardiac rupture were more frequently found in the group without furanthril whereas grave rhythm disorders were more frequent in the group with furanthril. The systematic administration of furanthril, in the first several days after the origination of the cardiac infarction, revealed some favorable tendencies in its course (possible restriction of lesion zone according to ECG Mapping data, restriction of necrosis according to enzyme activity data), but, at the same time, the unfavourable arrhythmia became more frequent, necessitating the control of rhythm and electrolytes as well as timely antirhythm treatment.
D000368:Aged; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001219:Aspartate Aminotransferases / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D004562:Electrocardiography; D005665:Furosemide / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy*
D007527:Isoenzymes; D005665:Furosemide; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase
Otchitane vuzdeistvieto na furantrila vurkhu goleminata na lezionnata zona pri surdechen infarkt po danni na prekordialnata elektrokartograma (meping) i enzimna aktivnost.