Ca2+-dependent binding of synthetic peptides corresponding to some regions of troponin-I to troponin-C.
We have chemically synthesized two peptides corresponding to the binding regions of troponin-I for troponin-C. Electrophoretic analysis has shown that one of the two peptides binds Ca2+-dependently to troponin-C and the other Ca2+-independently. The biological significance of the results is discussed. The interaction of the peptides with calmodulin was different from that with troponin-C.
D000595:Amino Acid Sequence; D002118:Calcium / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism; D009124:Muscle Proteins / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D011485:Protein Binding; D014336:Troponin / Q000378:metabolism*; D019209:Troponin C; D019210:Troponin I
D002147:Calmodulin; D009124:Muscle Proteins; D010446:Peptide Fragments; D014336:Troponin; D019209:Troponin C; D019210:Troponin I; D002118:Calcium