An enzymatic system for removing heparin in extracorporeal therapy.
The need to fully heparinize patients undergoing extracorporeal therapy often leads to hemorrhagic complications. To enable heparinization of only the extracorporeal circuit, a blood filter containing immobilized heparinase was developed. This filter degraded 99 percent of heparin's anticoagulant activity within minutes in both canine and human blood.
D005112:Extracorporeal Circulation; D005417:Flavobacterium / Q000201:enzymology; D006470:Hemorrhage / Q000517:prevention & control; D006493:Heparin / Q000097:blood*; D019763:Heparin Lyase; D006801:Humans; D011133:Polysaccharide-Lyases; D006435:Renal Dialysis / Q000009:adverse effects
D006493:Heparin; D011133:Polysaccharide-Lyases; D019763:Heparin Lyase