SCE induction in human lymphocytes by combined treatment with aniline  and norharman.
In human lymphocytes, aniline was unable to induce an increase of SCEs in vitro with or without metabolic activation by S9 mix. p-Aminophenol, one of the C-hydroxylation metabolites of aniline in the body, however, increased the SCE frequencies of lymphocytes at a concentration of 10-4 M. The addition of norharman to aniline plus S9 mix increased the SCE frequencies. The increase, however, was due to the SCE-inducing activity of norharman. These data show that the addition of norharman, which enhances the sensitivity of the Salmonella/microsome test, does not produce an enhancement of the sensitivity of the SCE test.
D000470:Alkaloids / Q000494:pharmacology*; D000627:Aminophenols / Q000494:pharmacology; D000814:Aniline Compounds / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001711:Biotransformation; D002243:Carbolines; D003434:Crossing Over, Genetic / Q000187:drug effects*; D006247:Harmine / Q000031:analogs & derivatives / Q000494:pharmacology*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D000470:Alkaloids; D000627:Aminophenols; D000814:Aniline Compounds; D002243:Carbolines; D006247:Harmine; C010262:norharman; C026729:4-aminophenol; C023650:aniline