The development of a new hemoperfusion column: the filmadsorber.
A hemoperfusion system has been developed in which very small charcoal particles (average diameter 40 micrometers) are embedded and immobilized in a collodion film (Filmadsorber). In vitro studies revealed that the absorption of bile acids by these small charcoal particles is superior to that by larger ones (size: 0.5 to 5 mm) as used in commercially available adsorbers. In vivo studies confirmed these results: dogs with ligated bile ducts were subjected to hemoperfusion through different types of charcoal adsorbers. Bile acid clearances of filmadsorbers containing less charcoal than the commercials were significantly higher.
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D002606:Charcoal; D004285:Dogs; D005999:Glycochenodeoxycholic Acid / Q000378:metabolism; D006382:Hemadsorption; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008107:Liver Diseases / Q000378:metabolism / Q000628:therapy
D001647:Bile Acids and Salts; D002606:Charcoal; D005999:Glycochenodeoxycholic Acid