Substrate induced alterations in tryptophan pyrrolase activity in two mouse strains.
Total hepatic L-tryptophan 2,3-dioxygenase activity was studied in 2 mouse strains receiving i.p. injections of L-tryptophan. After a single injection, enzyme activity was increased in albino but not pigmented mice. After 3 injections, enzyme activity was reduced in both strains.
D000417:Albinism / Q000201:enzymology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D014364:Tryptophan / Q000494:pharmacology*; D014366:Tryptophan Oxygenase / Q000378:metabolism*
D014364:Tryptophan; D014366:Tryptophan Oxygenase