Metabolism of palmitaldehyde in human cardiac muscle-II. Fatty chain elongation and shortening.
1. The metabolism of [1-14C[ palmitaldehyde has been studied in human heart homogenates. 2. Incorporation of the radioactivity into the individual acyl chains of nonpolar (NPL) and polar (PL) lipid fractions was assessed as well as changes in the weight percentage distribution of these chains. 3. Incorporation of the radioactivity into specific lipid fractions of free fatty acids (FFAcd), free fatty aldehydes (FFAld) and cholesterol esters were also studied. 4. A significant amount of incorporation into fatty chains of both fewer and more than 16 carbons was observed. 5. Chain shortening was found to be favored by NAD while the chain elongation required NADPH.
D000447:Aldehydes / Q000378:metabolism*; D002788:Cholesterol Esters / Q000096:biosynthesis; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction
D000447:Aldehydes; D002788:Cholesterol Esters; D005227:Fatty Acids; D009243:NAD; D009249:NADP; C001647:hexadecanal