Probucol: effects on the metabolism of low density and high density lipoproteins in moderate hypercholesterolaemia.
Seven patients with primary hypercholesterolaemia (baseline levels 7.5 to 13.1 mmol/l), and with no evidence of xanthomas, were treated with probucol 1 g daily. Plasma LDL-cholesterol decreased by 20% due to reduced LDL apo B synthetic rate. HDL-cholesterol also decreased; this fall was confined to the HDL3 subclass, while HDL2-cholesterol was unchanged.
D002784:Cholesterol / Q000097:blood; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000188:drug therapy; D007700:Kinetics; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D010636:Phenols / Q000494:pharmacology*; D011341:Probucol / Q000494:pharmacology* / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood
D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D010636:Phenols; D014280:Triglycerides; D002784:Cholesterol; D011341:Probucol