[Regulation of the functional activity of the stem cell precursors of granulo- and monopoiesis by polypeptide factors of the thymus and bone marrow].
Effect of polypeptide thymic and bone marrow factors on functional activity of stem cells was studied with the use of two-layer agar system containing human bone marrow hemopoietic cells. Unlike bone marrow factor, thymic factor appreciably increased the cluster- and colony-forming abilities of cells - precursors of granulomonopoiesis. The results indicate that thymic and bone marrow factors regulate different stages of stem cell differentiation.
D001853:Bone Marrow; D002478:Cells, Cultured; D006098:Granulocytes / Q000187:drug effects*; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D009000:Monocytes / Q000187:drug effects*; D010455:Peptides / Q000494:pharmacology*; D013950:Thymus Gland
D010455:Peptides
Reguliatsiia funktsional'noĭ aktivnosti stvolovykh kletok-predshestvennikov granulomonopoĕza polipetidnymi faktorami timusa i kosnogo mozga.