Do mast cell degranulators release prostaglandins from frog atria?
Isolated atria of frogs responded to compound 48/80 and d-tubocurarine with a delayed stimulation that showed tachyphylaxis and cross-tachyphylaxis indicating a common indirect mechanism. The blockers of H2-histamine, serotonin and beta-adrenergic receptors did not significantly antagonise these responses. However, in experiments with ex vivo and in vitro indomethacin-treated atria, the stimulant effects of mast cell degranulators were not observed, indicating a possible involvement of the prostaglandins.
D000818:Animals; D005260:Female; D006325:Heart Atria / Q000378:metabolism; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008407:Mast Cells / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D011453:Prostaglandins / Q000378:metabolism*; D011898:Ranidae; D013618:Tachyphylaxis; D014403:Tubocurarine / Q000494:pharmacology; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D011453:Prostaglandins; D003189:p-Methoxy-N-methylphenethylamine; D014403:Tubocurarine; D007213:Indomethacin