Effects of intravitreally injected DL-alpha-aminoadipic acid on the c-wave of the D.C.-recorded electroretinogram in albino rabbits.
The D.C. electroretinogram of four adult albino rabbits was studied 13.5 to 15 hr after injection of 0.1 ml of 0.15M DL-alpha-aminoadipic acid (alpha-AAA) into the vitreous body of one eye. The other eye was similarly injected with saline and served as control. In the alpha-AAA--treated eye the b-wave was markedly reduced or absent and the a- and c-waves increased compared with the control eye. Sincs alpha-AAA damages the Müller cells, the results support the view that these cells are related to the generation of the b-wave and to the negative slow PIII-potential, which modifies the positive pigment epithelial component of the c-wave.
D015074:2-Aminoadipic Acid / Q000494:pharmacology*; D000600:Amino Acids, Dicarboxylic / Q000494:pharmacology*; D000818:Animals; D004596:Electroretinography; D010857:Pigment Epithelium of Eye / Q000187:drug effects; D011817:Rabbits; D012160:Retina / Q000166:cytology / Q000187:drug effects*; D014822:Vitreous Body
D000600:Amino Acids, Dicarboxylic; D015074:2-Aminoadipic Acid