Enhanced percutaneous penetration with 1-dodecylazacycloheptan-2-one.
1-Dodecylazacycloheptan-2-one (Azone) is a new agent that enhances the percutaneous absorption of a number of different chemicals. This report delineates the enhancement of penetration of clindamycin phosphate, erythromycin base, fusidate sodium, fluorouracil, desonide, amcinonide, and triamcinolone acetonide. For this purpose 1-dodecylazacycloheptan-2-one can be used in concentrations as low as 1%. It is colorless, relatively odorless, nontoxic, and can be applied neat to human skin without any irritation.
D000287:Administration, Topical; D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001381:Azepines / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D051379:Mice; D008812:Mice, Hairless; D014677:Pharmaceutical Vehicles / Q000494:pharmacology; D012869:Skin Absorption / Q000187:drug effects*; D014661:Vasoconstriction / Q000187:drug effects
D000900:Anti-Bacterial Agents; D001381:Azepines; D004338:Drug Combinations; D014677:Pharmaceutical Vehicles; C035229:laurocapram