Effect of tropicamide on ocular blood flow in the rabbit.
Intracardiac injection of 15 microspheres labeled with 85Sr (strontium) and 141CE (cerium) were used to determine ocular blood flow in seven rabbits before and 25 min after bilateral application of tropicamide to the cornea. By using two different isotopes distinguishable under gammaspectrometry, each animal served as its own control. After administration of two drops of 1% tropicamide, no significant difference in blood flow between treated and untreated eyes was observed.
D000287:Administration, Topical; D000818:Animals; D002565:Cerium Radioisotopes / Q000008:administration & dosage; D005123:Eye / Q000098:blood supply* / Q000187:drug effects; D008297:Male; D008863:Microspheres; D011725:Pyridines / Q000494:pharmacology*; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D013326:Strontium Radioisotopes / Q000008:administration & dosage; D014331:Tropicamide / Q000494:pharmacology*
D002565:Cerium Radioisotopes; D011725:Pyridines; D013326:Strontium Radioisotopes; D014331:Tropicamide