Acyl-CoA: sn-glycerol-3-phosphate O-acyltransferase in rat brain mitochondria and microsomes.
The subcellular distribution of acyl-CoA: sn-glycerol-3-phosphate O-acyltransferase between brain mitochondria and microsomes was investigated. The activities associated with purified rat brain mitochondrial and microsomal preparations could be distinguished by differences in their acyl-CoA specificity, products of acylation, and sensitivity to N-ethylmaleimide, trypsin, acetone, and polymyxin B. It was concluded that both brain mitochondria and microsomes possess the acyltransferase.
D000096:Acetone / Q000494:pharmacology; D000217:Acyltransferases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D005033:Ethylmaleimide / Q000494:pharmacology; D005992:Glycerol-3-Phosphate O-Acyltransferase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008297:Male; D008861:Microsomes / Q000201:enzymology*; D008928:Mitochondria / Q000201:enzymology*; D011112:Polymyxin B / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013379:Substrate Specificity; D014357:Trypsin / Q000494:pharmacology
D000096:Acetone; D000217:Acyltransferases; D005992:Glycerol-3-Phosphate O-Acyltransferase; D014357:Trypsin; D011112:Polymyxin B; D005033:Ethylmaleimide