Behaviour of hematoporphyrin and protoporphyrin with antidepressant drugs.
Complexation between oppositely charged antidepressant drugs and porphyrin derivatives was investigated by NMR spectroscopy. The solid complexes obtained are soluble in antidepressant aggregates and a good fit was found between the values of CMC of the drugs and the values of the binding constants of porphyrins with antidepressant micelles.
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D002021:Buffers; D002626:Chemistry, Pharmaceutical; D005374:Filtration; D006415:Hematoporphyrins; D009391:Nephelometry and Turbidimetry; D011166:Porphyrins; D011524:Protoporphyrins; D012995:Solubility; D013500:Surface Tension
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D002021:Buffers; D006415:Hematoporphyrins; D011166:Porphyrins; D011524:Protoporphyrins