Synthesis and tissue distribution study of iodine-labeled benzyl- and xylylamines.
Four iodine-125 labeled mono- and diamines were prepared and evaluated as potential brain-imaging agents. The diamines are analogues of the previously reported selenium-75 labeled diamines, which show high brain uptake and retention. All of the radioiodinated amines display high initial brain uptake in rats after intravenous injection (1.7-2.4% dose/organ). The xylylenediamines show prolonged brain retention (t1/2 approximately 18 h), which is desirable for brain imaging. In contrast, the benzylamine is rapidly cleared from brain tissue (t1/2 approximately 15 min).
D000588:Amines / Q000138:chemical synthesis*; D000818:Animals; D001596:Benzylamines / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014018:Tissue Distribution; D014992:Xylenes / Q000138:chemical synthesis
D000588:Amines; D001596:Benzylamines; D007457:Iodine Radioisotopes; D014992:Xylenes