Promoting effects of 3-amino-1,2,4-triazole on the development of thyroid tumors in rats treated with N-bis(2-hydroxypropyl)nitrosamine.
3-Amino-1,2,4-triazole (AT) promoted the development of thyroid tumors in rats treated with a subeffective dose of N-bis(2-hydroxypropyl)nitrosamine (DHPN) for thyroid tumorigenesis. The incidences of thyroid tumors at the end of the 20-week experiment were 91% in rats injected s.c. once a week for four weeks with 70 mg DHPN per 100 g body weight and then given diet containing 2000 p.p.m. AT for 12 weeks, 100% in rats injected s.c. once a week for eight weeks with 70 mg DHPN per 100 g body weight and then given diet containing 2000 p.p.m. AT for 12 weeks, and 58% in rats injected s.c. once a week for 8 weeks with 70 mg DHPN per 100 g body weight. Rats only injected s.c. once a week for four weeks with DHPN or only given diet containing AT for 12 weeks had no thyroid tumors at the end of the experiment.
D000640:Amitrole; D000818:Animals; D002273:Carcinogens; D004357:Drug Synergism; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000139:chemically induced*; D014230:Triazoles
D002273:Carcinogens; D009602:Nitrosamines; D014230:Triazoles; C012457:diisopropanolnitrosamine; D000640:Amitrole