[Activity of fenfluramine in obese subjects. Relation between dosage, plasma concentration of the drug and its effect on weight loss].
Twenty-one patients have been submitted to hypocaloric diet and anorexigenic treatment with fenfluramine at variable doses. The weight loss, the plasma level concentration of fenfluramine (F) and norfenfluramine (NF) have been evaluated during a period of about 9 weeks. Statistical analysis demonstrates a significant weight loss and a highly significant correlation between the dose of administered drug and plasma level concentration of F and NF. No correlation instead has been found between weight loss and the dose administered of F, nor between weight loss and the dose administered of F, nor between weight loss and F and/or NF plasma level concentration.
D000328:Adult; D000368:Aged; D001835:Body Weight / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005277:Fenfluramine / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009642:Norfenfluramine / Q000097:blood / Q000627:therapeutic use; D009765:Obesity / Q000097:blood / Q000188:drug therapy*
D009642:Norfenfluramine; D005277:Fenfluramine
Attività della fenfluramina in soggetti obesi. Rapporti tra dosi, concentrazioni plasmatiche di farmaco e suoi effetti sul calo ponderale.