Serum triglyceride and cholesterol contents in male rats receiving diets containing plasticizers and analogues of the ester 2-ethylhexanol.
Male rats were administered diets containing the plasticizers di-(2-ethylhexyl) adipate and di-(ethyl)phthalate,, 2-ethylhexanol, hexanol, 2-ethylhexanoic acid, hexanoic acid, 2-ethylhexyl aldehyde, and hexyl aldehyde for 3 weeks, and serum triglyceride and cholesterol values were determined. Only those compounds which had been found to produce a proliferation of hepatic peroxisomes produced a decrease in both serum lipids.
D000818:Animals; D002784:Cholesterol / Q000097:blood*; D004032:Diet; D000441:Hexanols / Q000494:pharmacology*; D008297:Male; D008830:Microbodies / Q000187:drug effects; D010968:Plasticizers / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D014280:Triglycerides / Q000097:blood*
D000441:Hexanols; D010968:Plasticizers; D014280:Triglycerides; D002784:Cholesterol; C034017:2-ethylhexanol