[On the different release kinetics of water-soluble and lipid-soluble forms of hydroxyquinoline in oleogel ointment bases (author's transl)].
Studies using the model according to Horsch and Kögel showed that the release kinetics of the suspended water-soluble (but not lipid-soluble) drugs hydroxyquinoline sulphate and hydroxy-quinoline sulphate--potassium sulphate from oleogels is of a zero order. Differences in drug dispersity do not affect the release rates. Oleogels containing the lipid-soluble hydroxyquinoline base yielded undersaturated solution ointments, the release kinetics of which can be stated by a semilogarithmic relationship. There exists a linear correlation between the release rates and the product of the lipid solubility of the drug and the reciprocal apparent distribution coefficient.
D002626:Chemistry, Pharmaceutical; D005782:Gels; D006912:Hydroxyquinolines; D007700:Kinetics; D008055:Lipids; D008956:Models, Chemical; D009823:Ointment Bases; D012995:Solubility; D014867:Water
D005782:Gels; D006912:Hydroxyquinolines; D008055:Lipids; D009823:Ointment Bases; D014867:Water
Zur unterschiedlichen Liberationskinetik wasserlöslicher und lipidlöslicher Formen des Hydroxychinolins bei Oleogel-Salbengrundlagen.