Cell mediated immune response in miniature Sinclair swine bearing cutaneous melanomas.
Miniature Sinclair swine bearing cutaneous melanomas and nonmelanoma bearing littermate controls were tested for lymphocyte blastogenic response in a microculture assay. Lymphocytes were assayed for 3H-thymidine incorporation following stimulation with concanavalin A, phytohemagglutinin or pokeweed mitogen. Treatment with all mitogens revealed a significantly (p less than 0.05) reduced proliferative capacity in melanoma swine as compared to littermate controls. These results lend further support for the use of miniature Sinclair swine as a research model for human melanoma.
D000818:Animals; D004195:Disease Models, Animal; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects; D008545:Melanoma / Q000276:immunology / Q000662:veterinary*; D012878:Skin Neoplasms / Q000276:immunology / Q000662:veterinary*; D013045:Species Specificity; D013552:Swine; D013553:Swine Diseases / Q000276:immunology*
D037102:Lectins