Continuous maturation of proliferating erythroid precursors.
This study examines published steady state cell kinetic (mitotic and DNA synthesis phase) data from the recognizable proliferating erythroid precursors in humans, rats, and guinea-pigs, and human neutrophilic precursors, for consistency with a continuous maturation-proliferation model of the cell cycle. We find that these data are completely consistent with the hypothesis that maturation between morphological compartment may take place at any point in the cell cycle. A number of compartmental parameters are derived under this assumption.
D000818:Animals; D002453:Cell Cycle; D002454:Cell Differentiation; D002455:Cell Division; D004247:DNA / Q000096:biosynthesis; D004900:Erythroblasts / Q000166:cytology; D004920:Erythropoiesis; D006098:Granulocytes / Q000166:cytology; D006168:Guinea Pigs; D006410:Hematopoiesis; D006801:Humans; D008938:Mitosis; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains
D004247:DNA