[Could isolated mesangial deposits of C3 be responsible of glomerular hematuric nephropathies (author's transl)].
This communication presents three cases of prolonged macroscopic hematuria in young subjects. Complementary explorations eliminated urologic or vascular causes. Renal biopsies showed minimal glomerular lesions with light microscopy, normal basement membranes in electron microscopy and mesangial deposits of C3 and properdine in immunofluorescence. Although the mesangial deposits of C3 lack specificity and the number of observations is small, it appears useful to report such cases so as to indicate their frequency and perhaps their autonomy, in glomerular hematuric nephropathies.
D000328:Adult; D003176:Complement C3 / Q000032:analysis*; D006417:Hematuria / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007674:Kidney Diseases / Q000276:immunology / Q000473:pathology*; D007678:Kidney Glomerulus / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron
D003176:Complement C3
Les dépôts mésangiaux isolés de C3 peuvent-ils être responsables d'une néphrophathie hématurique?