Remodeling of large, persistent bone defects.
Large, standard, persistent, metaphyseal defects were surgically produced in adult dogs' distal femora to simulate clinical defects. Dogs were killed at intervals after surgery ranging from zero to 48 weeks. Biomechanical testing revealed that initially, the torsional strength was reduced to 44% of normal. A gradual return of torsional strength to 90% of normal occurred by 48 weeks. Roentgenographic and histologic studies of the animals and specimens correlated remodeled bone formation with increasing strength. In a small group of animals, suspected microfractures occurred early, induced bone regeneration, and resulted in accelerated recovery of strength.
D000818:Animals; D001847:Bone Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001861:Bone Regeneration; D004285:Dogs; D005269:Femur / Q000503:physiopathology; D011859:Radiography; D013314:Stress, Mechanical