Structure-activity studies on the mutagenicity of tris(2,3-dibromopropyl) phosphate (Tris-BP) and its metabolites in Salmonella.
A series of methylated metabolites of the flame retardant tris(2,3-dibromopropyl) phosphate (Tris-BP) were tested for mutagenicity in Salmonella, along with the parent chemical and other structurally related chemicals. The metabolites produced a gradient of mutagenic responses in TA1535 in the same dose range and up to the same magnitude as the Tris-BP response. None of the metabolites tested appeared to be the ultimate mutagen, since they all required S-9 for their mutagenic activity.
D000818:Animals; D001140:Aroclors / Q000633:toxicity; D008658:Inactivation, Metabolic; D008297:Male; D009153:Mutagens; D010755:Organophosphates / Q000378:metabolism / Q000633:toxicity*; D009943:Organophosphorus Compounds / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012475:Salmonella / Q000235:genetics*; D013329:Structure-Activity Relationship; D013347:Subcellular Fractions / Q000187:drug effects
D001140:Aroclors; D009153:Mutagens; D010755:Organophosphates; D009943:Organophosphorus Compounds; C012085:tris(2,3-dibromopropyl)phosphate