Electrochemical studies on nitroimidazole sensitizers: interaction with Co(II), Zn(II), and Fe(III) in biological media.
Misonidazole and desmethylmisonidazole react in chemical systems with metal ions such as Zn(II), Co(II), Fe(II) and Fe(III). The experiments carried out in the present work show that these reactions may involve the formation of a complex between the nitroimidazoles and the metal ions. Other experiments demonstrate that Co(II) and Zn(II) react differently with the nitroimidazoles when these reactions are studied in 20% serum solutions.
D003035:Cobalt; D004563:Electrochemistry; D005290:Ferric Compounds; D006863:Hydrogen-Ion Concentration; D008670:Metals; D008920:Misonidazole / Q000031:analogs & derivatives; D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents; D015032:Zinc
D005290:Ferric Compounds; D008670:Metals; D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents; D003035:Cobalt; D008920:Misonidazole; C009997:desmethylmisonidazole; D015032:Zinc