Search for the biochemical basis of biotin dependent multiple carboxylase deficiencies: determination of biotin activation in cultured fibroblasts.
D000249:Adenosine Monophosphate / Q000031:analogs & derivatives; D001710:Biotin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D019731:Carbon-Nitrogen Ligases; D002262:Carboxy-Lyases / Q000172:deficiency*; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D007700:Kinetics; D008025:Ligases / Q000378:metabolism*
D000249:Adenosine Monophosphate; D001710:Biotin; D002262:Carboxy-Lyases; D008025:Ligases; D019731:Carbon-Nitrogen Ligases; C023312:holocarboxylase synthetases