p-Amino salicylic acid - oxidized cellulose system: a model for long term drug delivery.
The mobilization of p-amino salicylic acid (PASA) on periodic oxidized cellulose (O.C) as a biocompatible carrier was investigated. The immobilization of the PASA is based on Schiff's base formation between the amino group of PASA and the aldehyde group of O.C. The in vivo and in vitro release of p-amino salicylic acid was studied. Such a system may be useful for the sustained delivery of the drugs in the body, since O.C. itself is a biosoluble carrier.
D010131:Aminosalicylic Acid / Q000008:administration & dosage* / Q000097:blood / Q000652:urine; D000636:Aminosalicylic Acids / Q000008:administration & dosage*; D000818:Animals; D003692:Delayed-Action Preparations; D007700:Kinetics; D011817:Rabbits; D013997:Time Factors
D000636:Aminosalicylic Acids; D003692:Delayed-Action Preparations; D010131:Aminosalicylic Acid