Metabolism of cadmium in the neonate: effect of hepatic zinc, copper and metallothionein concentrations on the uptake of cadmium in the rat liver.
The accumulation and subcellular distribution of Cd2+ (1 mg/kg body wt, i.p.) in the liver of the neonatal rat is age-dependent. At 4 hr after treatment the liver Cd2+ contents in the 12-day-old, 20-day-old and adult rat are similar and greater than in the 2-day-old animal. The differences in hepatic Cd2+ concentration in the older age groups are consistent with the nonlinear weight gain of the liver in the developing animal. In the hepatic cytosol Cd2+ is incorporated into a high molecular weight and metallothionein fractions and transferred from the former to the latter. This process occurs less rapidly with increasing age. The uptake of Cd2+ by the whole liver and th hepatic metallothionein is not related to the total liver concentration of Zn2+ or copper and is not significantly influenced by the concentration of pre-existing metallothionein or the concentration of thionein-bound Zn2+ or copper. The results are discussed in relation to the possible effects of Cd2+ on the liver metabolism and tissue distribution of Zn2+ and copper in the developing animal.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002104:Cadmium / Q000378:metabolism*; D003300:Copper / Q000032:analysis*; D005260:Female; D008099:Liver / Q000032:analysis / Q000378:metabolism*; D008297:Male; D008667:Metalloproteins / Q000032:analysis*; D008668:Metallothionein / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000032:analysis*
D008667:Metalloproteins; D002104:Cadmium; D003300:Copper; D008668:Metallothionein; D015032:Zinc