Concepts of multiple congenital contractures (arthrogryposis) in man and animals.
This is a concept of multiple congenital contractures, based upon clinical experience with the malformation and available literature, leading to a conception of the multiple categories of etiology, which cause neuropathic or myopathic muscle weakness or limb immobilization. The muscle weakness and imbalance of muscle power around the joints elicits a physiological compensatory collagenic response, which replaces atrophied muscle fibers with connective tissue and thickens the joint capsule sufficiently to result in prenatal fixation of limb segments at the joint.
D000818:Animals; D001102:Arbovirus Infections / Q000150:complications; D001176:Arthrogryposis / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D002417:Cattle; D002418:Cattle Diseases / Q000209:etiology; D004195:Disease Models, Animal; D005158:Facial Paralysis / Q000209:etiology; D005260:Female; D006801:Humans; D009045:Motor Endplate / Q000503:physiopathology; D009046:Motor Neurons / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D012756:Sheep; D012757:Sheep Diseases / Q000209:etiology; D013577:Syndrome