Electrocardiographic changes and serum concentrations in thioridazine-treated patients.
Electrocardiograms and serum concentrations of thioridazine and its metabolites were studied in 43 patients with paranoid psychosis. Two types of T-wave changes were distinguished: Type I with rounded, leveled, or notched T-waves, and Types II with diphasic waves. Significant positive correlations were found between serum drug concentrations and the Type I changes, while the Type II changes showed no concentration dependence. The two types of T-wave changes also differed in respect of prevalence, time of onset, duration, and variation with sex. The ECG response to thioridazine provides useful information about the serum drug concentrations.
D000293:Adolescent; D000328:Adult; D000368:Aged; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010259:Paranoid Disorders / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D013881:Thioridazine / Q000097:blood* / Q000494:pharmacology
D013881:Thioridazine