A new model of experimental Bacteroides fragilis infection in mice and rats.
We describe a method, based on Selye's granuloma pouch, for establishing reproducible Bacteroides fragilis infections in both mice and rats starting from rather low inocula. The infected pouches resemble abscesses and phlegmons. This model is promising for studies of antibiotic therapy in that both bacterial kinetics and antibiotic levels can be followed in the exudates.
D000818:Animals; D001442:Bacteroides Infections / Q000473:pathology*; D001441:Bacteroides fragilis; D004195:Disease Models, Animal; D005260:Female; D006099:Granuloma / Q000473:pathology; D007700:Kinetics; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains