Thyroid hormones affect the physiological availability of nonshivering thermogenesis.
Hypothyroid hamsters had a reduced capacity for heat production in the cold. This was correlated with a reduction of nonshivering thermogenesis (NST) as measured following an injection of tyramine, thereby releasing endogenous stores of noradrenaline (NA). However, when NST was measured following an injection of NA, the same capacity was found in controls and hypothyroid hamsters. This suggests that hypothyroidism decreased the availability of endogenous transmitters for cold induced stimulation of NST.
D000064:Acclimatization; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D006224:Cricetinae; D011441:Propylthiouracil; D013963:Thyroid Hormones / Q000502:physiology*; D014439:Tyramine / Q000494:pharmacology
D013963:Thyroid Hormones; D011441:Propylthiouracil; D014439:Tyramine