Coccidioidomycosis: evaluation of parameters used to predict outcome with amphotericin B therapy.
A literature review of case histories describing the use of amphotericin B for the treatment of disseminated coccidioidomycosis was performed to detect parameters that were predictive of therapeutic outcome. Several factors were significantly different between patients who were well during prolonged follow-up versus those with active or recurrent disease: 1) mean complement fixation (CF) titer before treatment was lower in patients who were well; 2) well patients had a greater magnitude fall in CF titer during the amphotericin B therapy; 3) mean CF titer after amphotericin B treatment was lower in patients who were well; and 4) patients with a positive coccidioidin skin test before therapy were more likely to be well at 6 months. There was no correlation between total amphotericin B dose or duration of therapy and therapeutic outcome.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use*; D000908:Antibodies, Fungal / Q000032:analysis; D002648:Child; D003045:Coccidioides / Q000276:immunology; D003047:Coccidioidomycosis / Q000188:drug therapy*; D003168:Complement Fixation Tests; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D013997:Time Factors
D000908:Antibodies, Fungal; D000666:Amphotericin B