A possible mechanism for increased susceptibility to aminoglycoside nephrotoxicity in chronic renal disease.
D000617:Aminoglycosides / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007674:Kidney Diseases / Q000503:physiopathology*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents