The effect of vitamin E on platelet kinetics of stroke-prone spontaneously hypertensive rats (SHRSP).
The platelet survival time was shortened in stroke-prone spontaneously hypertensive rats (SHRSP) at 10 weeks of age on feeding the regular diet but it was normalized on administering the vitamin E-supplemented diet. Platelet survival time was normal in stroke-resistant spontaneously hypertensive rats (SHRSR) at 10 weeks of age on feeding the regular diet but it was shortened when supplying the vitamin E-free diet. The maximal uptake of 75Se-selenomethionine by platelets was increased in SHRSP at 10 weeks of age on feeding the regular diet. It was further increased in SHRSP on feeding the vitamin E-free diet. On the other hand, the increased maximal uptake of 75Se-selenomethionine by platelets was normalized in SHRSP on feeding both the vitamin E-supplemented diet and the vitamin E-supplemented diet after administering the vitamin E-free diet. Therefore, we concluded that the deficiency of vitamin E brought about the shortening of platelet survival time and enhanced platelet production.
D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D002470:Cell Survival / Q000187:drug effects; D002561:Cerebrovascular Disorders / Q000097:blood*; D004198:Disease Susceptibility; D005260:Female; D006973:Hypertension / Q000097:blood* / Q000235:genetics; D007700:Kinetics; D008297:Male; D010976:Platelet Count; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium / Q000378:metabolism*; D012645:Selenomethionine / Q000378:metabolism*; D014810:Vitamin E / Q000494:pharmacology*; D014811:Vitamin E Deficiency / Q000097:blood
D014810:Vitamin E; D012645:Selenomethionine; D012643:Selenium