A silicone-nylon laminated dressing (IP-758) for closure of excised or débrided burn wounds.
A synthetic dressing (IP-758) consisting of a silicone membrane with a laminated layer of nylon fabric was evaluated in patients as a substitute for biological materials to cover excised areas of burn wounds. During a 3-day interval, the tissue developed a tightly adherent bond to the synthetic dressing. The IP-758 conformed to irregularly-shaped regions and stretched with the movements of the wound surface. Seventeen burned children from 3 to 12 years of age and 1 adult are included in this study. In 12 cases, the mean area covered with the synthetic ranged from approximately 39 to 118 cm2. The average dressing remained in place for 3 days and was replaced once. Microbiological sampling (wet swab technique) of the area under the IP-758 after application of second dressing was compared with open control sites treated with topical antibiotics. The results with Staphylococcus aureus, a frequent contaminant, were similar for the two test areas. The IP-758 site in 6 patients contained an average of 10 3 S. aureus per swab test. Immediately following removal of the adherent IP-758 and control of local bleeding, the wounds in most patients provided excellent sites for autografts. The IP-758 dressing is well-tolerated, elastic and adherent to the burn wound permitting maturation of the wound to readily accept autografts.
D000328:Adult; D002056:Burns / Q000601:surgery* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D003646:Debridement; D006801:Humans; D009757:Nylons; D009779:Occlusive Dressings; D012826:Silicone Elastomers / Q000627:therapeutic use*; D012828:Silicones / Q000627:therapeutic use*; D013211:Staphylococcus aureus / Q000302:isolation & purification
C033605:IP 758; D009757:Nylons; D012826:Silicone Elastomers; D012828:Silicones