Effect of stress on myocardial cells and blood levels of catecholamines in normal and amygdalectomized pigs.
The effects of restraint stress on heart activity, blood catecholamines and the development of myocardial necrosis were studied in five unoperated and five unsuccessfully amygdalectomized (sham-operated) pigs and compared with six bilaterally amygdalectomized pigs. In the sham-operated and the nonoperated animals, restraint stress often provoked intense tachycardia, as well as considerable elevations of blood catecholamines, particularly noradrenaline, associated with more or less widespread foci of myocardial necrosis. In contrast, the same restraint produced only minor heart rate increase in the six completely amygdalectomized animals; their blood noradrenaline levels were significantly lower and no myocardial necrosis could be detected, either macro- or microscopically. The results indicate that the amygdaloid part of the limbic system and the sympathoadrenal system are of importance in the induction of myocardial necrosis often noted in pigs when exposed to situations of severe mental stress.
D000679:Amygdala / Q000502:physiology* / Q000601:surgery; D000818:Animals; D004837:Epinephrine / Q000097:blood*; D005260:Female; D006339:Heart Rate; D008297:Male; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis; D009638:Norepinephrine / Q000097:blood*; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D013552:Swine
D009638:Norepinephrine; D004837:Epinephrine