Production of antibiotic SU-2 complex by a 2-deoxystreptamine idiotroph of Micromonospora sagamiensis.
A 2-deoxystreptamine idiotrophic mutant of Micromonospora sagamiensis, KY 11509, was found to produce unknown antibacterial substances, which were named SU-2 complex. Each component, SU-1, SU-2 and SU-3 were isolated from a culture broth of KY 11509. Chromatographic data suggested that these components were new antibiotics. The antibiotics exhibited potent and broad spectrum of antibacterial activity. The amount of SU-1, SU-2 and SU-3 production reached their maximum level (197, 82 and 58 micrograms/liter, respectively) in 3 to 4 days. Addition of cobalt chloride markedly stimulated SU-1 production but suppressed SU-2 and SU-3 production. Isolation of a mutant possessing a higher productivity of SU-2 complex is also described.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D005839:Gentamicins / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D006595:Hexosamines / Q000378:metabolism; D008847:Micromonospora / Q000235:genetics / Q000378:metabolism*; D009154:Mutation
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D006595:Hexosamines; C035067:Su-2 complex; C007265:2-deoxystreptamine