[Pretherapeutical testing of antineoplastic drugs in vitro (author's transl)].
Prediction tests were performed in vitro an organ cultures of different solid human tumors. The effectivity of the antineoplastic drugs was determined by means of the remained 3H-thymidine incorporation into DNA. DNA control values of different tumors (without drug) varying in a very high degree are analyzed and correspond to drug response rate in vitro. The correlation between results of sensitivity tests in vitro and therapeutic effectivity in vivo is discussed.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000378:metabolism; D046508:Culture Techniques; D004247:DNA / Q000378:metabolism; D004351:Drug Resistance; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D013936:Thymidine / Q000378:metabolism
D000970:Antineoplastic Agents; D004247:DNA; D013936:Thymidine
Prätherapeutische Testung von Antineoplastischen Pharmaka in vitro.