Rectal absorption of diazepam in epileptic children.
The absorption of diazepam after rectal administration was studied in children with epilepsy. When given as a solution, diazepam was rapidly absorbed and produced serum diazepam concentrations above 200 ng/ml within 10 minutes in most children. However, a commercial suppository formulation was absorbed slowly and cannot be recommended for urgent treatment of fits. There is a need in the UK for a rapidly absorbed preparation of diazepam which is approved for rectal use.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003975:Diazepam / Q000008:administration & dosage / Q000378:metabolism*; D004827:Epilepsy / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption; D012007:Rectum / Q000378:metabolism*; D012996:Solutions; D013488:Suppositories; D013997:Time Factors
D012996:Solutions; D013488:Suppositories; D003975:Diazepam