The contractile proteins in muscular dystrophy: an analytical review and a new hypothesis.
The reduced capacity for force generation that is characteristic of muscle fibers in Duchenne muscular dystrophy is a predictable consequence of the alteration of sarcomere length that has been reported in this form of muscle disease in the early stages. Evidence that the primary defect may be a disorder of the cross-bridge cycle itself is reviewed.
D000199:Actins / Q000502:physiology; D000818:Animals; D003285:Contractile Proteins / Q000502:physiology*; D006801:Humans; D009119:Muscle Contraction; D009132:Muscles / Q000503:physiopathology*; D009136:Muscular Dystrophies / Q000503:physiopathology*; D012519:Sarcoplasmic Reticulum / Q000502:physiology; D014335:Tropomyosin / Q000502:physiology; D014336:Troponin / Q000502:physiology
D000199:Actins; D003285:Contractile Proteins; D014335:Tropomyosin; D014336:Troponin