Lysosomotropic agents ammonium chloride and chloroquine inhibit both the synthesis and secretion of procollagen by freshly isolated embryonic chick tendon cells.
D000643:Ammonium Chloride / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D002738:Chloroquine / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism; D011347:Procollagen / Q000096:biosynthesis / Q000378:metabolism*; D013710:Tendons / Q000187:drug effects / Q000378:metabolism*
D011347:Procollagen; D000643:Ammonium Chloride; D002738:Chloroquine