Pharmacokinetics of continuous intravenous and subcutaneous infusions of cytosine arabinoside.
The pharmacokinetics of continuous subcutaneous cytosine arabinoside (ara-C) infusions were compared with continuous intravenous infusions. Steady-state serum ara-C levels and myelosuppression were similar with both routes of administration. CSF/serum ara-C ratios ranged from 0.14 to 0.91 (mean, 0.58). Continuous subcutaneous ara-C infusions were a convenient and reliable alternative to intravenous infusions.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003561:Cytarabine / Q000008:administration & dosage / Q000097:blood* / Q000134:cerebrospinal fluid; D006801:Humans; D007263:Infusions, Parenteral; D007700:Kinetics
D003561:Cytarabine