Urodynamic evaluation of patients with hereditary ataxias.
Seventeen patients with Friedreich's ataxia or spastic ataxia were subjected to an urodynamic evaluation. Fifty-three per cent (53%) of the patients presented with urinary symptoms consisting of urgent micturition and urgency incontinence. Cystometric evaluation showed a lack of inhibition of the detrusor in 7 patients (41%). Abnormal electric hyperactivity of the external sphincter was documented in 6 cases (37.5%) by electromyography. Some hypotheses are presented to explain the etiology of these abnormal findings.
D000293:Adolescent; D000328:Adult; D001259:Ataxia / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D005621:Friedreich Ataxia / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008365:Manometry; D009119:Muscle Contraction; D009128:Muscle Spasticity / Q000235:genetics; D014521:Urethra / Q000503:physiopathology; D001743:Urinary Bladder / Q000503:physiopathology; D001750:Urinary Bladder, Neurogenic / Q000175:diagnosis; D014550:Urinary Incontinence, Stress / Q000175:diagnosis; D014555:Urination Disorders / Q000235:genetics* / Q000503:physiopathology