[Action of N-dinitrosopiperazine and N-nitrosodiethylamine on aquarium guppies].
Tumors and precancerous lesions of the gastrointestinal tract were induced in aquarium fish guppy by dinitrosopiperazine and nitrosodiethylamine dissolved in aquarium water. Nitrosodiethylamine appeared to produce a stronger blastogenic effect than dinitrosopiperazine. Since tumors develop several weeks after exposure to carcinogens, this animal species may be used for express testing nitrosocompounds for blastogenicity.
D000818:Animals; D004052:Diethylnitrosamine / Q000494:pharmacology*; D005260:Female; D005393:Fish Diseases / Q000139:chemically induced* / Q000473:pathology; D005399:Fishes; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D009602:Nitrosamines / Q000494:pharmacology*; D011230:Precancerous Conditions / Q000139:chemically induced / Q000473:pathology
D009602:Nitrosamines; D004052:Diethylnitrosamine; C026156:N,N'-dinitrosopiperazine
Izuchenie deĭstviia N-dinitrozopiperazina i N-nitrozodiétilamina na akvariumnykh ryb guppi.