The pharmacokinetics and pharmacodynamics of minaxolone.
Plasma concentrations of minaxolone were measured in 15 female patients during and for up to 3 hours after a minaxolone and nitrous oxide anesthetic. Nine patients received a single dose and six patients two or three doses of minaxolone. Plasma minaxolone decay can be described by two-compartment kinetics. Distribution is rapid, with a mean half-life of 2.1 minutes, and the elimination half-life is short (47 minutes). Plasma clearance is high (1.55 l./min). Plasma levels of minaxolone at recovery were similar in patients receiving both single and multiple doses, suggesting a valid relationship between plasma level and effect. It is suggested that minaxolone may be a suitable agent for administration by continuous infusion.
D000328:Adult; D000758:Anesthesia; D000777:Anesthetics / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D011278:Pregnanes / Q000378:metabolism*; D011280:Pregnanolone / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology
D000777:Anesthetics; D011278:Pregnanes; C020413:minaxolone; D011280:Pregnanolone