Hepatic function in rats with dietary-induced fatty liver, as measured by the uptake of indocyanine green.
1. The hepatic uptake of indocyanine green (ICG) has been measured in rats receiving a 50 g protein/kg diet for 6, 12 or 20 d or a choline-deficient diet for 2 or 6 d. 2. There was no effect on ICG uptake on the choline-deficient diet, although all the rats developed an intense fatty infiltration of the liver by 6 d. 3. The rats on the 50 g protein/kg diet showed impaired uptake of ICG at 6, 12 and 20 d, which appeared to be related to the extent of fatty infiltration. 4. It is concluded that ICG uptake is predominantly a function of the periportal zone of the liver lobule, and therefore likely to be sensitive to insults that exert their predominant effect in this zone.
D000818:Animals; D002796:Choline Deficiency / Q000150:complications / Q000503:physiopathology; D005234:Fatty Liver / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D007208:Indocyanine Green; D008099:Liver / Q000378:metabolism / Q000503:physiopathology*; D008111:Liver Function Tests; D008297:Male; D011488:Protein Deficiency / Q000150:complications / Q000503:physiopathology; D051381:Rats; D013997:Time Factors
D007208:Indocyanine Green