Accumulation of radionuclide-labeled platelets and fibrinogen in paraquat-damaged rat lungs.
After intraperitoneal injection of paraquat, rats showed evidence of neurologic and respiratory damage and had a mortality rate of 41% in 3 days. The lungs quadrupled in weight between the third and the fifth day. Pulmonary edema and extravascular fibrin and platelets were identified by light and transmission electron microscopy. As early as 4 h after injection of the paraquat, 51Cr from labeled platelets began accumulating in the lungs. The peak was reached by 48 h; 125I from labeled fibrinogen also concentrated in the lungs of treated rats. Total complement was unchanged. The paraquat-treated rat is a suitable model for study of the behavior of fibrin and platelets in permeability pulmonary edema. Disturbances of copper metabolism deserve further investigation.
D000818:Animals; D001777:Blood Coagulation; D001792:Blood Platelets / Q000378:metabolism*; D002570:Ceruloplasmin / Q000032:analysis; D002860:Chromium Radioisotopes; D003165:Complement System Proteins / Q000502:physiology; D003300:Copper / Q000097:blood; D005340:Fibrinogen / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010269:Paraquat / Q000506:poisoning*; D010314:Partial Thromboplastin Time; D051381:Rats; D011919:Rats, Inbred Strains
D002860:Chromium Radioisotopes; D007457:Iodine Radioisotopes; D003300:Copper; D005340:Fibrinogen; D003165:Complement System Proteins; D002570:Ceruloplasmin; D010269:Paraquat