Effect of selenium on growth rate of canine mammary carcinoma cells in athymic nude mice.
A canine mammary tumor cell line established from a carcinoma of the solid type was used in this study. In 2 separate experiments, athymic nude mice were inoculated subcutaneously with 5 x 10(6) viable tumor cells. All tumor-bearing mice received subcutaneous injections thrice weekly of 2 micrograms/g body wt of selenium as sodium selenite or phosphate buffered saline. Control, non-tumor-bearing mice were injected with either selenium or buffer. Selenium administration did not significantly alter the growth of non-tumor-bearing mice. However, body weight of tumor-bearing mice was reduced approximately 10%. The average volume of tumors in selenium treated mice was reduced 76% in experiment I and 74% in experiment II.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004285:Dogs; D005260:Female; D007422:Intestines / Q000032:analysis; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D008325:Mammary Neoplasms, Experimental / Q000032:analysis / Q000473:pathology*; D051379:Mice; D008819:Mice, Nude; D012643:Selenium / Q000097:blood / Q000494:pharmacology*; D013997:Time Factors
D012643:Selenium