Pyridoquinoxaline N-oxides. 1. A new class of antitrichomonal agents.
An aspect of our work with quinoxaline 1,4-dioxides involved the synthesis and reactivity of (quinoxalin-2-yl)acrylonitrile 1,4-dioxide. We have found that treatment of a methanolic solution of this unsaturated nitrile (cis or trans) with primary alkylamines affords a novel series of pyrido[2,3-b]quinoxaline 5-oxides. These tricyclic pyridoquinoxalines represent a unique class of agents with oral activity against trichomoniasis.
D000818:Animals; D000994:Antitrichomonal Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D051379:Mice; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D014245:Trichomonas Infections / Q000188:drug therapy
D000994:Antitrichomonal Agents; D011810:Quinoxalines