A deconvolution program for processing radiotracer dilution curves.
We present a computer program for deconvolution of noisy signals. The unknown signal is modelled as a stochastic process and the solution is given by the 'maximum a posteriori estimator'. This is computed by two algorithms: the first uses and the Kalman filter; the second the conjugate gradient technique which permits introduction of a positivity constraint. The program has proved to give accurate results in stimulation studies. It has been applied to the deconvolution analysis of radionuclide angiocardiography time-activity curves. This improves the reliability of the results in left-to-right cardiac shunt quantitation.
D000790:Angiocardiography / Q000379:methods*; D006328:Cardiac Catheterization; D003201:Computers; D006321:Heart / Q000000981:diagnostic imaging* / Q000502:physiology; D006331:Heart Diseases / Q000000981:diagnostic imaging*; D008433:Mathematics; D011877:Radionuclide Imaging