[Effects of prolactin on lipid metabolism (author's transl)].
Effects of prolactin (PRL) on lipid metabolism were examined in the patients with hyperprolactinemia and rabbits. Significant correlation between serum PRL and triglyceride (TG) levels was observed in the patients with hyperprolactinemia (r = 0.417, p less than 0.05). Serum TG levels in non-pregnant adult rabbits were elevated in feeded states by the administration of o-PRL. Marked changes were not observed in the activity of plasma lipoprotein lipase in rabbits by the administration of o-PRL, but in in vitro experiments, the up-take of 14C-acetate into lipid fraction of rabbit liver slice significantly increased by the addition of o-PRL. These findings suggest that PRL activates TG synthesis in liver and consequently increases serum TG levels. The serum levels of TG, free fatty acid, cholesterol and glucose significantly rose in rabbits' fetuses after the administration of o-PRL intraperitoneally. These facts also suggest that the high levels of PRL in maternal and fetal serum and amniotic fluid may have some roles in the growth of the fetus through lipid metabolism.
D000293:Adolescent; D000328:Adult; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008071:Lipoprotein Lipase / Q000097:blood; D008099:Liver / Q000378:metabolism; D011388:Prolactin / Q000097:blood / Q000494:pharmacology*; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D014280:Triglycerides; D011388:Prolactin; D002784:Cholesterol; D008071:Lipoprotein Lipase