Influence of pyridoxine on the oxygen transport function of blood in the neonatal period in clinical and experimental conditions.
A significant increase of the P50 value of blood (the pO2 value of O2 half saturated blood at 37 degrees C, pH 7.40 and pCO2 of 5.33 kPa) was observed on symptom free premature newborns, mature newborns requiring intensive care and newborn rabbits treated with high dose of pyridoxine (Vitamin B6). The change seemed to be independent of the 2,3-DPG content of blood. The moderate but consistently favourable influence of vitamin B6 treatment on the O2 transport function of blood can be advantageous in early postnatal adaptation disturbances of newborns.
D019794:2,3-Diphosphoglycerate; D000818:Animals; D004163:Diphosphoglyceric Acids / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood / Q000188:drug therapy*; D007235:Infant, Premature, Diseases / Q000097:blood / Q000188:drug therapy; D010100:Oxygen / Q000097:blood*; D011736:Pyridoxine / Q000627:therapeutic use*; D011817:Rabbits
D004163:Diphosphoglyceric Acids; D019794:2,3-Diphosphoglycerate; D011736:Pyridoxine; D010100:Oxygen