Synthesis of N7-hydroxyethylguanine and O6-hydroxyethylguanine. Markers for the reaction of ethylene oxide (EO) with DNA.
O6-Hydroxyethylguanine has been synthesized by reaction of mono-sodium glycolate with 6-chloroguanine. The crystalline product has been characterized using a variety of analytical techniques and compared with a sample of the corresponding N7-hydroxyethyl derivative. These 2 chemicals may prove useful as standards when studying the reaction of ethylene oxide (EO) with DNA.
D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA / Q000378:metabolism; D005027:Ethylene Oxide / Q000494:pharmacology; D006147:Guanine / Q000031:analogs & derivatives* / Q000032:analysis / Q000138:chemical synthesis; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009153:Mutagens / Q000494:pharmacology
D009153:Mutagens; C035018:N(7)-hydroxyethylguanine; D006147:Guanine; C030920:6-hydroxyethylguanine; D004247:DNA; D005027:Ethylene Oxide