Cerebrospinal fluid vasopressin and oxytocin: evidence for an osmotic response.
A push-pull perfusion technique was used to sample third ventricular cerebrospinal fluid (CSF) in the conscious rat. Ventricular perfusate contained significant quantities of vasopressin and oxytocin, 13.1 and 4.5 pg/ml, respectively. Vasopressin and oxytocin levels were stable over a 3 h perfusion period. High sodium artificial CSF elicited a 4-5-fold stimulation of perfusate concentrations of both peptides. These findings suggest that the CSF represents a dynamic compartment in terms of neuroendocrine function.
D000818:Animals; D002552:Cerebral Ventricles / Q000502:physiology; D008297:Male; D009994:Osmolar Concentration; D010121:Oxytocin / Q000134:cerebrospinal fluid*; D010477:Perfusion; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology; D014667:Vasopressins / Q000134:cerebrospinal fluid*
D014667:Vasopressins; D012965:Sodium Chloride; D010121:Oxytocin