Cefuroxime prophylaxis in caesarean section.
A double-blind, randomized prospective study was carried out in 96 women in labour requiring caesarean section to assess the value of antibiotic prophylaxis with cefuroxime compared with placebo. Forty-six patients received 750 mg cefuroxime intravenously before and every 8 hours for the first 72-hours post-operatively; the other 50 women received placebo injections. A significant decrease in post-operative morbidity was observed in the drug-treated group, there were far fewer endometrial, urinary and pulmonary injections, and those who received prophylactic cefuroxime had less days of hospitalization than the placebo-treated group. No serious side-effects were observed.
D002444:Cefuroxime / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D002585:Cesarean Section; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007743:Labor, Obstetric; D011183:Postoperative Complications / Q000382:microbiology; D011247:Pregnancy; D011292:Premedication
D002511:Cephalosporins; D002444:Cefuroxime