Transport of horseradish peroxidase by processes of radial glia from the pial surface into the mouse brain.
The transport of horseradish peroxidase (HRP) applied to exposed pial surfaces of the brain was studied in newborn, 4-, 7- and 12-day-old, and adult mice. In the telencephalon the cell bodies of radial glia were found to accumulate the tracer. Labeled cells occurred in the subventricular zone of the lateral ventricle during the first postnatal week; they became gradually restricted to an area around the stria terminalis (ventrolateral ventricular corner) by day 12. At later stages no HRP transport could be traced from the surface of the telencephalon. In the cerebellum, HRP was transported from the surface to the cell bodies of Bergmann glia in all age groups studied including adult animals. It is concluded that radial glia and their derivatives share the capacity of transporting material between various cerebrospinal fluid compartments.
D000818:Animals; D001692:Biological Transport; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D002531:Cerebellum / Q000166:cytology / Q000378:metabolism; D006735:Horseradish Peroxidase / Q000378:metabolism; D051379:Mice; D009457:Neuroglia / Q000378:metabolism*; D010841:Pia Mater / Q000378:metabolism*; D013687:Telencephalon / Q000378:metabolism
D006735:Horseradish Peroxidase