[Effect of long-wave ultraviolet radiation on the cyclophosphamide-induced frequency of chromosome aberrations in mouse bone marrow cells].
The paper deals with the influence of 1-month pretreatment of mice with different regimes of long-wave UV-radiation on spontaneous and cyclophosphamide (CP) induced levels of chromosome aberrations in the bone marrow cells. The level of aberrant cells in the bone marrow of control and CP treated mice was not changed by the suberythematous dose (0.5 of the erythematous dose) of UV-radiation. The mice pretreatment with 3 erythematous doses of UV-radiation significantly increased spontaneous and CP induced level of cells with chromosome aberrations as compared with that in UV-unexposed mice.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects*; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D051379:Mice; D014466:Ultraviolet Rays
D003520:Cyclophosphamide
Vliianie dlinnovolnovogo ul'trafioletovogo izlucheniia na indutsirovannuiu tsiklofosfamidom chastotu khromosomnykh aberatsiĭ v kletkakh kostnogo mozga mysheĭ.