l-Tyrosine as an immunological adjuvant.
A series of experiments has been carried out to investigate the adjuvant properties of the amino acid L-tyrosine in laboratory animals. Adsorption of various allergenic materials to L-tyrosine was found to enhance the induction of IgG antibodies, but no unusual propensity to stimulate IgE antibody or delayed hypersensitivity was observed. Administration of the amino acid at a site remote from the allergen was found not to augment antibody production. This, together with evidence of reduced bioavailability of the tyrosine-adsorbed allergen, suggested that the adjuvant activity observed resulted from a short-term depot effect.
D000276:Adjuvants, Immunologic; D000327:Adsorption; D000818:Animals; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000209:etiology; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D011058:Pollen / Q000276:immunology; D014443:Tyrosine / Q000276:immunology* / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D014443:Tyrosine