The use of labetalol in producing deliberate hypotension and its effects on intracranial pressure in dogs.
The use of effective and safe hypotensive agents in neuroanesthesia is a difficult and unanswered question. Most hypotensive agents produce an increase in intracranial pressure and as a result can not be used until the dura is opened. In experiments in dogs, Labetalol, a combined alpha and beta-adrenoceptor antagonist, showed no increase in intracranial pressure and no change in intracranial compliance by producing hypotension.
D000758:Anesthesia; D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007023:Hypotension, Controlled / Q000379:methods*; D007427:Intracranial Pressure / Q000187:drug effects*; D007741:Labetalol / Q000494:pharmacology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D004983:Ethanolamines; D007741:Labetalol