Nature of the endocochlear dc potential in kanamycin-poisoned guinea pigs.
The endocochlear dc potential (EP) was measured in normal guinea pigs and in a group poisoned with kanamycin sulfate for 60 minutes after the administration of furosemide intravenously (IV) or by perfusion into the scala tympani. The EP decreased rapidly and developed a large negative potential after IV administration of furosemide, but the EP decreased more slowly and did not develop a negative potential in kanamycin-poisoned animals. With perfusion of the scala media, the EP declined slowly and did not develop a large negative potential in either group. With perfusion of the scala tympani, the EP declined slowly in the kanamycin-poisoned animals and did not develop a large negative potential, while in the normal animals the EP declined rapidly and developed a large negative potential.
D000818:Animals; D003051:Cochlea / Q000502:physiology*; D003053:Cochlear Duct / Q000187:drug effects; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005665:Furosemide / Q000494:pharmacology; D006168:Guinea Pigs; D007263:Infusions, Parenteral; D007612:Kanamycin / Q000008:administration & dosage / Q000506:poisoning*; D010477:Perfusion; D012533:Scala Tympani / Q000187:drug effects; D013316:Stria Vascularis / Q000502:physiology*
D007612:Kanamycin; D005665:Furosemide