Porcine sensitized lymph node cells (immunotherapy) and attenuated irradiation for infiltrative transitional cells carcinoma of bladder.
Thirty-four patients wih infiltrative bladder carcinoma, Stage B2C or higher were treated with immunotherapy and irradiation. Seventeen patients are alive, and 17 have succumbed to their disease. Eight patients underwent cystectomy after immunotherapy and irradiation; 6 of 8 are alive and well at the present time. The technique of immunotherapy is outlined. New methodology for sequential CT scans and scheduled bladder biopsies is mentioned. The 17 patients have survived twelve to sixty-nine months after immunotherapy and irradiation. Downstaging is demonstrated based on sequential CT scans of the bony pelvis and histologic biopsy. The biopsies reveal eosinophilia and multinucleated giant cells, a specific response to immunotherapy. A prospective randomized study will be initiated.
D000328:Adult; D000368:Aged; D000818:Animals; D002295:Carcinoma, Transitional Cell / Q000401:mortality / Q000628:therapy*; D005260:Female; D006801:Humans; D007167:Immunotherapy; D008198:Lymph Nodes / Q000166:cytology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage; D013552:Swine / Q000276:immunology; D014057:Tomography, X-Ray Computed; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000628:therapy*