Prevention of thioacetamide-induced liver necrosis by prior aminoacetonitrile or imidazole administration.
Prior administration of aminoacetonitrile (AAN) or imidazole but not isoxazole to rats, was able partially to prevent thioacetamide (TAC)-induced liver necrosis at 24 h. AAN and isoxazole did not prolong the pentobarbital sleeping time of the rats, while imidazole did. These and previous observations suggest a possible participation of non-cytochrome P-450 (P-450)-dependent aminoxidases in TAC activation to a necrogenic metabolite.
D000081:Acetamides / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D000097:Acetonitriles / Q000494:pharmacology*; D000607:Aminoacetonitrile / Q000494:pharmacology*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000517:prevention & control*; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D009336:Necrosis / Q000517:prevention & control; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects; D013853:Thioacetamide / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D013997:Time Factors
D000081:Acetamides; D000097:Acetonitriles; D007093:Imidazoles; D013853:Thioacetamide; D000607:Aminoacetonitrile; C029899:imidazole; D010424:Pentobarbital