Cochlear cytoarchitecture and ribostamycin ototoxicity.
Ribostamycin ototoxicity was tested in a group of 28 albino guinea-pigs of both sexes, body-weight about 250-450 g with auricular Prayer's reflex present. The mounting of the cochlea on a metal support and the scanning electron microscope observations are described, The cochleacytogram of the group treated daily with 200 mg/kg ten days consecutively is comparable to that of the non-treated group.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D003051:Cochlea / Q000187:drug effects* / Q000648:ultrastructure; D005260:Female; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000648:ultrastructure; D006199:Hair Cells, Auditory, Inner / Q000648:ultrastructure; D007760:Labyrinth Supporting Cells / Q000648:ultrastructure; D008297:Male; D008855:Microscopy, Electron, Scanning; D009925:Organ of Corti / Q000648:ultrastructure; D012271:Ribostamycin / Q000633:toxicity*
D000900:Anti-Bacterial Agents; D012271:Ribostamycin