[Effects of furosemide on renal functions in prematures (author's transl)].
Renal effects of Furosemide were examined during the first 2-4 days of life in preterm infants suffering from respiratory distress syndrome. Administration of the drug was followed by a sevenfold increase of diuresis. This latter was a result of both a rise in sodium excretion and glomerular filtration. The possible mechanism of Furosemide induced alteration in the glomerular filtration is discussed. Furosemide also altered the hydrogen-ion excretion: both the urinary bicarbonate, the titratable acidity and the ammonium excretion increased. There was a significant rise in the net acid excretion and hydrogen clearance too. It has been found that besides its diuretic effect Furosemide might play a role in the renal hydrogen elimination.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D005260:Female; D005665:Furosemide / Q000627:therapeutic use*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D006819:Hyaline Membrane Disease / Q000188:drug therapy; D007231:Infant, Newborn; D007677:Kidney Function Tests; D008297:Male; D010547:Persistent Fetal Circulation Syndrome / Q000188:drug therapy; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy*; D014882:Water-Electrolyte Balance / Q000187:drug effects
D005665:Furosemide
Die Wirkung von Furosemid auf die Nierenfunktion von Frühgeborenen mit Atemnotsyndrom.