Gas chromatographic determination of 1,2-propanediol dinitrate in blood.
A method is described for determination of 1,2-propanediol dinitrate in blood at concentrations ranging from 10 ng/ml up to 25,000 ng/ml. It used double ether extraction with manual shaking in order to complete sample preparation within 5 min. Samples are analyzed via gas chromatography-electron-capture detection using a column of 3% base deactivated SP-2250 on Supelcoport. This column provides excellent separation and little 1,2-propanediol dinitrate tailing.
D002849:Chromatography, Gas / Q000379:methods; D006801:Humans; D011409:Propylene Glycols / Q000097:blood*; D012016:Reference Values
D011409:Propylene Glycols; C031030:propylene glycol dinitrate