Pharmacological modulation of neutrophil phagocytic function in a patient with recurrent sepsis, pyoderma gangrenosum and impaired phagocytosis.
A 50-year-old man with recurrent life-threatening sepsis and a cutaneous condition resembling pyoderma gangrenosum, was found to have a defect of neutrophil phagocytic function. Phagocytosis could be enhanced by corticosteroids, both in vitro in a dose-dependent manner, and in vivo, when it was accompanied by rapid clinical improvement. Studies with steroid hormones and immuno-stimulatory drugs are described.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D001424:Bacterial Infections / Q000276:immunology; D002991:Clofazimine / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007978:Levamisole / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009277:Nandrolone / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology*; D010587:Phagocytosis / Q000187:drug effects*; D011711:Pyoderma / Q000276:immunology*; D012008:Recurrence; D012883:Skin Ulcer / Q000276:immunology*; D013739:Testosterone / Q000494:pharmacology
D000305:Adrenal Cortex Hormones; D007978:Levamisole; D013739:Testosterone; D009277:Nandrolone; D002991:Clofazimine