Caffeine antagonizes diazepam effects in man.
In a double-blind, placebo-controlled study on parallel groups of medical students diazepam 10 mg impaired cognitive skills and caused muscle relaxation. A 250 mg dose of caffeine given in decaffeinated coffee counteracted these better than a 500 mg dose. Subjectively, diazepam exerted a calming effect which was counteracted by caffeine at either at either dose levels.
D000328:Adult; D002110:Caffeine / Q000494:pharmacology*; D003975:Diazepam / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005425:Flicker Fusion / Q000187:drug effects; D006801:Humans; D008297:Male; D008606:Mental Processes / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D010919:Placebos; D013694:Temperament / Q000187:drug effects
D010919:Placebos; D002110:Caffeine; D003975:Diazepam