Penetration of alafosfalin and ampicillin into tissue cage fluid in rabbits.
The pharmacokinetics of alafosfalin and ampicillin were studied in rabbits. Serum concentrations were compared to levels in subcutaneous tissue fluid obtained from implanted tissue cages. The concentrations of alafosfalin exceeded those of ampicillin and the drugs were eliminated at similar rates from serum and tissue fluid.
D000409:Alanine / Q000031:analogs & derivatives* / Q000378:metabolism; D000667:Ampicillin / Q000378:metabolism*; D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism*; D001826:Body Fluids / Q000378:metabolism*; D007700:Kinetics; D008954:Models, Biological; D011817:Rabbits; D013997:Time Factors
D000890:Anti-Infective Agents; C006437:alafosfalin; D000667:Ampicillin; D000409:Alanine