Familial benign intracranial hypertension and depression.
Two sisters developed benign intracranial hypertension (BIH) two weeks following the resolution of a major depressive episode. The association of BIH and a major affective disorder in genetically related individuals has not been previously reported to our knowledge. Both conditions are associated with disturbances in the hypothalamic-pituitary-adrenal axis. Falling corticosteroid levels in a resolving depression may result in impaired cerebrospinal fluid absorption and subsequent BIH.
D000328:Adult; D003866:Depressive Disorder / Q000150:complications*; D005260:Female; D006801:Humans; D011559:Pseudotumor Cerebri / Q000175:diagnosis / Q000235:genetics / Q000523:psychology*