Role of the state of reduction of the NAD system on the regulation of hepatic protein synthesis in the rat in vivo.
1. The administration of octanoate to rats in vivo increased the state of reduction of the hepatic NAD system and decreased the phosphorylation potential. This effect was accompanied by a 20% inhibition of protein synthesis. 2. The acute administration of ethanol produced similar reduction of the hepatic NAD system; however, in contrast to octanoate no effect on the phosphorylation potential was detected and rates of protein synthesis were unaffected. 3. It is concluded that a rise in the state of reduction of the NAD system is not effective in decreasing hepatic protein synthesis in vivo unless it is accompanied by a decrease in the phosphorylation potential.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002210:Caprylates / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D008099:Liver / Q000378:metabolism*; D008297:Male; D009243:NAD / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010084:Oxidation-Reduction; D010766:Phosphorylation; D014176:Protein Biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
D002210:Caprylates; D009243:NAD; D000431:Ethanol; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate