Toxicity studies of the toxins isolated from annual ryegrass (Lolium rigidum) infected by Corynebacterium rathayi.
Estimates of the LD50's of 7 glycolipid toxins (corynetoxins) isolated from toxic annual ryegrass varied in the range 0 . 1-1 . 3 mg/kg in 2-week-old rats. The delay in onset of neurological signs in rats and sheep was independent of dose rate and could be the result of inhibition of protein biosynthesis. In sheep, no influence of the route of administration on the delay in onset of neurological signs was demonstrated. The relationship between the partial structures of the two major corynetoxins and their toxicity is discussed.
D000818:Animals; D003352:Corynebacterium / Q000254:growth & development*; D006017:Glycolipids / Q000633:toxicity*; D007928:Lethal Dose 50; D009422:Nervous System Diseases / Q000139:chemically induced / Q000662:veterinary*; D006109:Poaceae / Q000382:microbiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced*; D014118:Toxins, Biological / Q000633:toxicity*
D006017:Glycolipids; D014118:Toxins, Biological