Effect of diazepam on hepatocarcinogenesis in the rat.
The promotion effect of diazepam on the hepatocarcinogenesis initiated by 3'-methyl-4-(dimethyl-amino)azobenzene(3'-Me-DAB) in the rat was studied. Weanling rats were fed a diet containing 0.06% 3'-Me-DAB for 3 weeks, followed by either the basal diet or a diet containing 0.05% diazepam. The number and the size of enzyme-altered islands greater than 50 micrometers in diamter were scored at week 16. The feeding of diazepam did not increase the number and the size of enzyme-altered islands significantly, in comparison with those scored in animals fed 3'-Me-DAB alone. It was concluded that diazepam is not a promoter like phenobarbital in hepatocarcinogenesis.
D000818:Animals; D003975:Diazepam / Q000494:pharmacology*; D004032:Diet; D004347:Drug Interactions; D008099:Liver / Q000201:enzymology; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008749:Methyldimethylaminoazobenzene / Q000633:toxicity; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats
D008749:Methyldimethylaminoazobenzene; D003975:Diazepam; D010634:Phenobarbital