Blood lipids in young men followed 32 years.
The relationship of baseline characteristics to serum cholesterol at baseline (CHL47) when aged 16-25 (mean 20.5) yr and at 32-yr follow-up (CHL79) was assessed in 162 men. Mean CHL rose over the follow-up period. CHL47 predicted CHL79 (r = 0.61, p less than 0.001) but not CHL79-CHL47. The mean (+/- SD) weight change (DW) was 12.0 kg (+/- 26.0 kg). DW was not significantly related to CHL47, but was independently related to CHL79-CHL47 (4 = 0.30, p less than 0.001). Age, height, DW, any of 7 measures of baseline obesity and CHL47 predicted CHL79 with R2 of 0.40 and CHL79-CHL47 with R2 of 0.37. Thus, weight change but not baseline relative weight was a determinant of serum cholesterol change from youth to middle age. There was strong tracking of serum cholesterol over this period.
D000328:Adult; D000367:Age Factors; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005500:Follow-Up Studies; D006801:Humans; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D012044:Regression Analysis; D013223:Statistics as Topic; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol