Influence of two alpha-globin gene deletions on homozygous beta 0-thalassemia.
The favorable influence of alpha-thalassemia due to a deletion of two alpha-globin genes (alpha-thal-l) on homozygous beta 0-thalassemia in an adult Chinese woman is described. Her clinical and hematologic condition was milder than usually seen in homozygous beta 0-thalassemia. With the help of repeated blood transfusions immediately before delivery she gave birth to a physically healthy baby who had the alpha-thal-l trait due to two alpha-globin gene deletions with Hb Bart's in the cord blood.
D000328:Adult; D002872:Chromosome Deletion; D005260:Female; D005914:Globins / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D013789:Thalassemia / Q000235:genetics*
D005914:Globins