Evidence suggesting that DMI-induced resistance to extinction is not mediated by the dorsal noradrenergic bundle.
Rats were trained to press a lever for food rewards, then given a 5 week break, followed by a single extinction session. Animals which received 14 daily desmethylimipramine (DMI) injections, ending 4 days before the extinction session, showed resistance to extinction; no effect was seen in animals which received DMI during acquisition. The opposite pattern of results would be predicted if the effect were mediated by changes in the efficacy of the dorsal noradrenergic bundle.
D000818:Animals; D001921:Brain / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects*; D003891:Desipramine / Q000494:pharmacology*; D005108:Extinction, Psychological / Q000187:drug effects*; D008125:Locus Coeruleus / Q000187:drug effects*; D008297:Male; D009115:Muridae; D009434:Neural Pathways / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism*
D003891:Desipramine; D009638:Norepinephrine