1,4-Bis(4-guanylphenylethyl)benzenes as potential antitrypanosomal agents.
A series of 1,4-bis(4-guanylphenylethyl)benzenes, including masked amidines in which the guanyl function is incorporated into a heterocyclic ring, were prepared for screening as potential antitrypanosomal agents. Some of these compounds were active against Trypanosoma rhodesiense in mice. The diamidines were prepared by standard methods from 1,4-bis(4-cyanophenylethyl)benzene which was obtained from 1,4-bis(4-cyanostyryl)benzene by diimide reduction. The latter compound was prepared by the Wittig reaction between 4-cyanobenzylphosphonium ylide and terephthaldicarboxaldehyde.
D000818:Animals; D001645:Biguanides / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D008968:Molecular Conformation; D013329:Structure-Activity Relationship; D014344:Trypanocidal Agents / Q000138:chemical synthesis*
D001645:Biguanides; D014344:Trypanocidal Agents