Familial Bartter's syndrome.
Two sisters were found to have Bartter's syndrome. Both had hypokalemia, hyperreninemia, normal BPs, and decreased pressor responses to angiotensin II. During a water diuresis, patient 1 had an abnormally low distal tubular fractional reabsorption of chloride initially, but this normalized after hypokalemia was corrected for one year. Patient 2 had no demonstrable defect in chloride transport. Hypokalemia in Bartter's syndrome may be caused by some hereditary mechanisms other than defective reabsorption of chloride in the distal tubules.
D000042:Absorption; D000328:Adult; D000804:Angiotensin II / Q000037:antagonists & inhibitors; D001477:Bartter Syndrome / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D002712:Chlorides / Q000378:metabolism; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000235:genetics*; D007686:Kidney Tubules, Distal / Q000378:metabolism; D011188:Potassium / Q000097:blood
D002712:Chlorides; D000804:Angiotensin II; D011188:Potassium