Neonatal myasthenia gravis in the infant of an asymptomatic thymectomized mother.
A case of neonatal myasthenia gravis is reported in the infant of an asymptomatic thymectomized mother with comparably elevated acetylcholine receptor (AChR) antibody titers. The mother remained asymptomatic despite elevated antibody titers while the infant became asymptomatic in association with the disappearance of the AChR antibody. It is suggested that the AChR antibody plays an essential role in the development of neonatal myasthenia gravis. It is also suggested that a thymic factor is necessary for the development of clinical symptomatology accounting for the lack of correlation between the clinical state of the mother and infant.
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000235:genetics*; D009157:Myasthenia Gravis / Q000235:genetics* / Q000276:immunology / Q000628:therapy; D011863:Radioimmunoassay; D011950:Receptors, Cholinergic / Q000276:immunology; D013934:Thymectomy
D001323:Autoantibodies; D011950:Receptors, Cholinergic