Histamine and gastric acid secretion in rabbits: mechanism of inhibition.
Supramaximal doses of histamine inhibit gastric acid secretion in rabbits. Mepyramine partially blocks this action of histamine. Catecholamine concentrations in the gastric mucosa are not changed during infusion of histamine. It is concluded that in rabbits the inhibitory effect of histamine on acid secretion is not connected with a change in local catecholamine content.
D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002395:Catecholamines / Q000378:metabolism; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology*; D011738:Pyrilamine / Q000494:pharmacology*; D011817:Rabbits; D013270:Stomach / Q000502:physiology; D013997:Time Factors
D000631:Aminopyridines; D002395:Catecholamines; D006632:Histamine; D011738:Pyrilamine