Partial protection of the gastric toxicity of regional 5-fluorouracil infusion by thymidine and cimetidine.
Gastric ulceration resulted from regional (infusion) chemotherapy when high doses of 5-fluorouracil were accidently infused into the stomach during hepatic artery infusions. A method for reproduction of those ulcers was established by gastric artery infusions. A trial to protect against such development with thymidine produced only partial protection. Measurement of gastric acid output in animals receiving one dose of 5-fluorouracil showed no change in basal acid secretion but a significant decrease in histamine-stimulated output. Partial protection from ulcer development was also accomplished with cimetidine alone.
D000818:Animals; D002927:Cimetidine / Q000627:therapeutic use*; D004285:Dogs; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D006146:Guanidines / Q000627:therapeutic use*; D007261:Infusions, Intra-Arterial / Q000009:adverse effects; D013270:Stomach / Q000098:blood supply / Q000187:drug effects; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000517:prevention & control; D013936:Thymidine / Q000627:therapeutic use*
D006146:Guanidines; D002927:Cimetidine; D005472:Fluorouracil; D013936:Thymidine