Chromosomal aberrations induced by ethylene oxide in a human amniotic cell line in vitro.
Ethylene oxide was found to be a potent inducer of chromatid-type aberrations in a human amniotic cell line. This induction was dose-dependent. At doses corresponding to about 9% survival, the number of chromatid exchanges was increased about 20 times, and the number of induced breaks increased 50 times, above that observed in the controls.
D000650:Amnion / Q000187:drug effects*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D005027:Ethylene Oxide / Q000494:pharmacology*; D005260:Female; D006801:Humans; D011247:Pregnancy; D012854:Sister Chromatid Exchange / Q000187:drug effects
D005027:Ethylene Oxide