Local cerebral glucose utilization in the beagle puppy model of intraventricular hemorrhage.
Local cerebral glucose utilization has been measured by means of carbon-14(14C)-autoradiography with 2-deoxyglucose in the newborn beagle puppy model of intraventricular hemorrhage. Our studies demonstrate gray matter/white matter differentiation of uptake of 14C-2-deoxyglucose in the control pups, as would be expected from adult animal studies. However, there is a marked homogeneity of 14C-2-deoxyglucose uptake in all brain regions in the puppies with intraventricular hemorrhage, possibly indicating a loss of the known coupling between cerebral blood flow and metabolism in this neuropathological condition.
D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002543:Cerebral Hemorrhage / Q000134:cerebrospinal fluid / Q000378:metabolism* / Q000503:physiopathology; D002552:Cerebral Ventricles; D002560:Cerebrovascular Circulation; D003847:Deoxyglucose / Q000378:metabolism; D004195:Disease Models, Animal; D004285:Dogs; D005947:Glucose / Q000378:metabolism*
D002250:Carbon Radioisotopes; D003847:Deoxyglucose; D005947:Glucose