[Comparative effectiveness of sister chromatid exchange induction with ethyleneimine derivatives in a human lymphocyte culture].
The efficiency of SCE induction by six ethylene imine derivatives has been studied in the culture of human lymphocytes. It is found that there is a linear relation between SCE and a dose, irrespective of the number of functional groups and their distribution in the molecule. Hexamethyl triamid which has no functional ethylene imine groups does not induce SCE. The monocentric agents are more active than bicentric ones. A linear increase of SCE induced by a monofunctional agent does not agree with Shafer's bypass model.
D001388:Aziridines / Q000494:pharmacology*; D001389:Azirines / Q000494:pharmacology*; D002478:Cells, Cultured; D003434:Crossing Over, Genetic / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D012996:Solutions; D013329:Structure-Activity Relationship
D001388:Aziridines; D001389:Azirines; D012996:Solutions
Sravnitel'naia éffektivnost' induktsii sestrinskikh khromatidnykh obmenov proizvodnymi étilenimina v kul'ture limfotsitov cheloveka.