Pharmacokinetic behavior of S-carboxymethylcysteine-Lys in patients with chronic bronchitis.
A mass fragmentographic technique was used to study the pharmacokinetic behavior of SCMC-Lys in patients with acute exacerbations of chronic bronchitis and with dense expectoration. Serum and urine levels, as well as bronchial mucus levels and their correlations, were determined. The data suggest that SCMC-Lys diffuses well into bronchial mucus, a useful feature for a mucolytic drug.
D001980:Bronchi / Q000378:metabolism; D001991:Bronchitis / Q000188:drug therapy*; D002233:Carbocysteine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D002908:Chronic Disease; D003545:Cysteine / Q000031:analogs & derivatives*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007700:Kinetics; D009093:Mucus / Q000378:metabolism
C034932:carbocysteine-lysine; D002233:Carbocysteine; D003545:Cysteine