Plasma alpha- and beta-mannosidase activities in caprine beta-mannosidosis.
Plasma alpha- and beta-mannosidase activities were measured in goats with beta-mannosidosis, a recently discovered, inherited deficiency of the glycohydrolase beta-D-mannosidase. Plasma beta-mannosidase activity in the affected animals was zero at 1 and 4 weeks after they were born. Enzyme values of age-matched, unaffected goats were between 66 and 222 nmol/hr/ml of plasma, alpha-Mannosidase activities were similar in both affected and unaffected animals. This investigation indicates that deficiency of plasma beta-mannosidases activity may be diagnostic of beta-mannosidosis.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D005260:Female; D006041:Goats / Q000378:metabolism; D008297:Male; D008361:Mannosidases / Q000097:blood* / Q000378:metabolism; D008661:Metabolism, Inborn Errors / Q000097:blood / Q000201:enzymology / Q000662:veterinary*; D010375:Pedigree; D043323:alpha-Mannosidase; D044902:beta-Mannosidase
D008361:Mannosidases; D043323:alpha-Mannosidase; D044902:beta-Mannosidase