An analysis of auditory brainstem responses in infants.
Acoustic brainstem responses (ABRs) were recorded from 148 infants from 4 to 60 weeks of age. 28 subjects returned to the laboratory 3 or more times for additional recordings. Filtered clicks of 1, 2, 4 and 8 kHz were presented at two intensities, 30 and 50 dB HL re the average threshold for a group of young adults. Responses to a broadband click, 50 dB nHL, were also recorded. The latencies of waves I, III and V were measured. Wave I latencies for the 8 kHz filtered click showed no change but those for lower frequencies decreased with age. The latency decreases with age were largest for wave V, and, among the filtered clicks, was largest for the responses to 1 kHz. Best-fitting curves were determined for latency vs. age for each filtered click and for the broadband click. Wave V--Wave I latency differences showed that the rostral conduction time for responses to the 8 kHz FC decreased with age and, for the 1 kHz filtered click (50 dB), remained constant. The early development of basal regions in the cochlea is viewed as insuring the delivery of a wide range of frequencies to rostral segments of the auditory system. The limiting feature of maturation is at rostral sites. The immature auditory system appears to be fully capable of transducing low frequency stimuli, but not high frequencies.
D000161:Acoustic Stimulation; D000367:Age Factors; D001307:Auditory Perception / Q000502:physiology*; D001933:Brain Stem / Q000502:physiology*; D003051:Cochlea / Q000254:growth & development / Q000502:physiology; D005072:Evoked Potentials, Auditory; D006309:Hearing / Q000502:physiology; D006801:Humans; D007223:Infant; D011930:Reaction Time; D012684:Sensory Thresholds