Structure elucidation of mammalian TCDD-metabolites.
Thin layer and gas chromatographic examination of the bile of dogs which were given tritium-labelled TCDD revealed the presence of several polar biotransformation products. The structure of 5 phenolic metabolites was elucidated by combined gas chromatography-mass spectrometry. A metabolic breakdown scheme for TCDD in the dog is proposed.
D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D004147:Dioxins / Q000378:metabolism*; D004285:Dogs; D013058:Mass Spectrometry; D000072317:Polychlorinated Dibenzodioxins / Q000378:metabolism*
D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins