Reductive metabolism of halothane by human and rabbit cytochrome P-450. Binding of 1-chloro-2,2,2-trifluoroethyl radical to phospholipids.
D000818:Animals; D017402:Chlorofluorocarbons; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D005609:Free Radicals; D006221:Halothane / Q000378:metabolism*; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000378:metabolism*; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000378:metabolism; D010084:Oxidation-Reduction; D010634:Phenobarbital / Q000494:pharmacology; D010743:Phospholipids / Q000378:metabolism*; D011817:Rabbits
D017402:Chlorofluorocarbons; D005227:Fatty Acids; D005609:Free Radicals; D006846:Hydrocarbons, Halogenated; D010743:Phospholipids; C035562:1-chloro-2,2,2-trifluoroethyl radical; D003577:Cytochrome P-450 Enzyme System; D006221:Halothane; D010634:Phenobarbital