[Occurrence of HLA B27 antigen in ankylosing spondylitis in Italy].
39 individuals from Middle and South Italy were selected for being affected by ankylosing spondylitis (AS) (N = 22) or by sacroiliitis (SI) (N = 17) and typed for the HLA system antigens. 320 healthy individuals were typed as control population. The following phenotypic frequencies of HLA-B27 were found; 68% in AS patients, 71% in SI patients and 5% in controls. The frequency of B27 observed among our AS patients is lower than those observed in other caucasian patients. Our data may be explained either by a genetic hypothesis or by an environmental hypothesis; data reported by other authors let we believe that the last one is more reliable.
D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007558:Italy; D010641:Phenotype; D011859:Radiography; D012446:Sacroiliac Joint / Q000000981:diagnostic imaging; D013167:Spondylitis, Ankylosing / Q000235:genetics*; D044465:White People
D006680:HLA Antigens
Contribution à l'étude de la fréquence de l"antigène HLA B27 dans la spondylite ankylosante en Italie.