Neonatal seizures. I. Correlation of prenatal and perinatal events with outcomes.
A review of 277 newborns with neonatal seizures enrolled in the Collaborative Perinatal Project revealed a mortality of 34.8%. Of the 181 survivors, most followed up to age 7 years, 70% were normal. Thus, despite the fact that seizures are a major indicator of perinatal asphyxia and a predictor of subsequent neurologic deficit, most infants with neonatal seizures who survived did well. Thirteen percent had cerebral palsy, 19% had an IQ less than 70, and 20% had epilepsy. Thirteen percent of survivors had a combination of mental retardation, cerebral palsy, or epilepsy. A low Apgar score, the need for resuscitation after 5 minutes of age, low birth weight, and the early onset of seizures or prolonged seizures correlated with adverse outcome.
D001034:Apgar Score; D002547:Cerebral Palsy / Q000150:complications; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000150:complications; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D008607:Intellectual Disability / Q000150:complications; D008297:Male; D012640:Seizures / Q000150:complications* / Q000175:diagnosis / Q000401:mortality