Hyperpigmentation associated with oral minocycline.
Two patient receiving minocycline developed blue-black pigmentation on the legs. Biopsies from the pigmented areas demonstrated granules containing iron, a pigment with staining properties similar to melanin, and a third pigment which may be a degradation product of minocycline. Electron microscopy showed that some, but not all the granules were membrane-bound and they were situated mainly within macrophages. Analytical electron microscopy showed that the granules contained iron, sulphur, chlorine and, in one case, calcium.
D000328:Adult; D003594:Cytoplasmic Granules / Q000032:analysis; D005260:Female; D006801:Humans; D007501:Iron / Q000032:analysis; D008297:Male; D008911:Minocycline / Q000009:adverse effects*; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000473:pathology; D012867:Skin / Q000032:analysis; D013754:Tetracyclines / Q000009:adverse effects*
D013754:Tetracyclines; D007501:Iron; D008911:Minocycline