[Phospholipid composition of mucous membrane tissue in the gastrointestinal tract of rabbits in simulated Salmonella infections].
The paper deals with the phospholipid composition in the mucosa tissue of different areas of gastrointestinal tract and in membranes of the villous margin of small intestine enterocytes under conditions of experimental salmonellosis infection. A decreased relative content of cardiolipin is observed in all periods of the infection process in the stomach mucosal tissue and in the period of the disease height and convalescence--in the sigmoid colon. Phosphatidyl choline appears in the tissue of duodenum and jejunum during the height of the infection process. An increase in a relative content of lysophosphatidyl choline and phosphatidyl serine and a decrease in that of phosphatidyl ethanolamine are revealed in membranes of enterocyte villous margin when modelling the diarrhea process by the intraperitoneal administration of the lipopolysaccharide complex of salmonellas. The found changes in the composition of phospholipids in the mucous membrane tissue and membranes of the enterocytes villous margin are supposed to reflect alterations in the functional state of the intestine barrier and play a definite role in development of the diarrhea syndrome.
D000818:Animals; D004195:Disease Models, Animal; D004386:Duodenum / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism*; D008871:Microvilli / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D011817:Rabbits; D012480:Salmonella Infections / Q000378:metabolism*
D008563:Membrane Lipids; D010713:Phosphatidylcholines; D010743:Phospholipids
Sostav fosfolipidov tkani slizistoĭ obolochki zheludochno-kishechnogo trakta krolikov pri modelirovanii sal'monelleznoĭ infektsii.