Acute hepatitis B in infants born to HBsAG asymptomatic carrier mothers.
Within an eight-month period, five cases of acute hepatitis B were observed in children born to asymptomatic HBsAg carrier mothers. At delivery, four mothers were HBeAg-positive and one was anti-HBe-positive. At an average age of 17+/-3 weeks the infants showed high transaminases levels and appearance of markers of HBV infection. Three children became HBsAG chronic carriers, one had a brief HBsAg-antigenemia (1 week), while the last one showed clinical and biochemical signs of hepatitis B in absence of detectable HBsAg but with anti-HBc and anti-HBe (window phase) and later became anti-HBs-positive.
D000208:Acute Disease; D002353:Carrier State; D005260:Female; D006509:Hepatitis B / Q000235:genetics / Q000276:immunology / Q000635:transmission*; D006514:Hepatitis B Surface Antigens; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008111:Liver Function Tests; D008297:Male; D011247:Pregnancy
D006514:Hepatitis B Surface Antigens