Hypothyroidism and growth failure in diabetes mellitus.
The prevalence of thyroid disease in 134 children, adolescents, and young adults with diabetes mellitus beginning in childhood is described. Clustering of a family history of thyroid disease and the presence of thyrogastric antibodies in some patients supports the concept of familial autoimmunity. In 4 children a diagnosis of hypothyroidism had already been made, one of whom had shown marked faltering of growth. In a further 3 there was evidence of previously unrecognised subclinical hypothyroidism but the growth of 2 of them had been good. The findings of this study indicate that while subclinical hypothyroidism should be considered in a diabetic whose growth is faltering, it is rarely a cause of such growth failure.
D000293:Adolescent; D001323:Autoantibodies / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000276:immunology; D005260:Female; D006130:Growth Disorders / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000276:immunology; D008297:Male; D013270:Stomach / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology; D013972:Thyrotropin / Q000097:blood
D001323:Autoantibodies; D013972:Thyrotropin