Studies in Stobbe condensation. Part 7: Synthesis and biological activity of some new cyclopentadienones and cyclopentadienes.
The condensation of cinnamaldehyde, thienyl and furyl acrolein with dimethyl succinate in the presence of potassium tert-butoxide, gives the corresponding acid-esters (la-c) (R1 = Me) as major products. These esters are further converted into cyclopentadiene and cyclopentadienone derivatives. Dicondensation products (2a-c) are also obtained. Furthermore, the correlation between the chemical structures of the studied compounds and their respective biological activities were discussed.
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D003517:Cyclopentanes