[Clinical results and safety of drip infusion of gentamicin in complicated chronic urinary tract infections].
1. Clinical pharmacology: The pharmacological studies on gentamicin (GM) were carried out in some clinical patients. The peak serum level following intramuscular injection (i.m.) of GM 60 mg was 4.69 microgram/ml after 1 hour. When same dose of the drug was given by drip infusion (d.i.) over 1.5 and 2 hours, the peak serum concentrations were 5.17 microgram/ml and 5.08 microgram/ml, respectively. No marked differences in the results of pharmacokinetic studies between i.m. and d.i. were observed. 2.


RESULTS
GM was administered in a dose of 60 mg once or twice a day by d.i. against 18 cases with chronic complicated UTIs. The duration of treatment varied but usually 5 days. An overall excellent or moderate effect was seen in 78% with the criteria proposed by the UTI committee. 3. Clinical chemistry and laboratory findings: The clinical abnormal values from laboratory tests of renal, hepatic functions and peripheral hematology in patients treated with GM were observed in 1 case which was a slight increase of BUN (12.5 approximately 22.2 mg/dl) and a slight elevation of GOT (30.g approximately 48.6 u). The abnormal values, however, returned to normal within 10 days after the discontinuance of the drug. 4. Clinical tolerance: No adverse reactions were encountered in all treated cases. 5.


CONCLUSIONS
Based on the clinical pharmacology and clinical studies, drip infusion administration of GM can be given safely and effectively in treatment of chronic complicated UTI.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004341:Drug Evaluation; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D006801:Humans; D007263:Infusions, Parenteral; D007273:Injections, Intramuscular; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014552:Urinary Tract Infections / Q000188:drug therapy*
D005839:Gentamicins