Comparison of the xenon-133 washout curve and radioactive microsphere distribution in the normal and hypoperfused dog kidney.
Intrarenal blood flow distribution was measured in normal and hypoperfused dog kidneys by xenon-133 washout measurement in one kidney vary slightly in contrast to those done in different kidneys. In normal kidneys the ratio of compartment I (CI) flow to whole renal flow -- i.e., the CI fraction--as measured by the xenon-133 washout curves is almost identical with the distribution of radioactive microspheres in the outer three-fourths of renal cortex (= SI). In hypoperfused dog kidneys, both techniques demonstrate redistribution of blood flow due to reduction predominantly in the CI fraction and the SI zone. The CI fraction is smaller than the microsphere distribution in zone SI in 3 of 5 hypoperfused kidneys. This is explained on the basis of increased cortical flow inhomogeneity in the hypoperfused kidneys.
D000818:Animals; D004285:Dogs; D005260:Female; D008297:Male; D008863:Microspheres; D010477:Perfusion; D012079:Renal Circulation; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes