Replication variants of the human inactive X chromosome. I. Variability within lymphocytes of single individuals.
The sequence of DNA replication was studied within the inactive X chromosome in human lymphocytes, by means of the FPG method. Several variants of the replication sequence were found. The number of variants in the cells of a single donor exceeded 2 in each of the 4 normal individuals studied. The phenomenon is discussed with respect to the regulation of DNA synthesis and to the cell differentiation process.
D002453:Cell Cycle / Q000187:drug effects; D002478:Cells, Cultured; D002871:Chromosome Banding; D004261:DNA Replication; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008727:Methotrexate / Q000494:pharmacology; D012730:Sex Chromosomes / Q000502:physiology*; D014960:X Chromosome / Q000502:physiology*
D008727:Methotrexate