Effects of L-alanine on ketogenesis in vitro.
Alanine (5 mM) increased 14CO2 production from [1-14C]oleate by 130% and from [1-14C]butyrate by 101%. Alanine inhibited ketone-body production by 37.5% in the presence of butyrate but did not affect ketogenesis in the presence of oleate. Alanine decreased the [3-hydroxybutyrate]/[acetoacetate] ratio when either butyrate or oleate was present. The results are discussed with reference to the hypoketonaemic action of alanine in vivo.
D000409:Alanine / Q000494:pharmacology*; D000818:Animals; D002087:Butyrates / Q000378:metabolism; D020148:Butyric Acid; D002250:Carbon Radioisotopes; D005260:Female; D066298:In Vitro Techniques; D007657:Ketone Bodies / Q000096:biosynthesis*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D019301:Oleic Acid; D009829:Oleic Acids / Q000378:metabolism*; D051381:Rats
D002087:Butyrates; D002250:Carbon Radioisotopes; D007657:Ketone Bodies; D009829:Oleic Acids; D020148:Butyric Acid; D019301:Oleic Acid; D000409:Alanine