[Hypotheses on the tumoral nature of fibrocystic mastopathy. Review of bibliographic data and experimental immunologic tests].
The literature on fibrocystic mastopathy has been reviewed and it is noted that, if considered to be a dyplasia pure and simple, it is hard to fit the disease into the biphasic framework of cancer growth; its histopathological picture and development are very suggestive of cancer, it has the same experimental models as breast cancer; there are episodic contradictory results when it is submitted to immunological testing. On these bases, 16 cases of fibrocystic mastopathy have been put through the LAI test according to Thompson. It was found that the disease is antigenic in its clear stage, and that the pictures preceding and following it have a typical immunological index (NAI). With these and reported data, it is concluded that there are sound experimental bases for hypothesising that in its clear stage, fibrocystic mastopathy is a benign tumour of the breast.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D001941:Breast Diseases / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D005348:Fibrocystic Breast Disease / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007957:Leukocyte Adherence Inhibition Test; D051381:Rats; D014020:Tissue Extracts
D000951:Antigens, Neoplasm; D014020:Tissue Extracts
Ipotesi sulla natura tumorale della mastopatia fibro-cistica. Revisione dei dati bibliografici e prove immunologiche sperimentali.