Excretion of TTCA in human urine after administration of disulfiram.
2-Thiothiazolidine-4-carboxylic acid (TTCA) was measured in urine of two persons given an oral dose of 250 mg disulfiram. Maximum concentrations up to 0.33 mmol TTCA/mol creatinine were found, 10 to 14 h after dosing. The total amounts of TTCA excreted in urine were 1.8 and 3.5 mumol, respectively, which correspond to 0.2 and 0.4% of the dose.
D000328:Adult; D002246:Carbon Disulfide / Q000378:metabolism; D004221:Disulfiram / Q000378:metabolism*; D006801:Humans; D008297:Male; D013844:Thiazoles / Q000652:urine*; D053778:Thiazolidines
D013844:Thiazoles; D053778:Thiazolidines; C031677:2-thioxo-4-thiazolidinecarboxylic acid; D002246:Carbon Disulfide; D004221:Disulfiram