Chronobiological study of pituitary adenomas and of the empty sella syndrome.
A chronobiological study was carried out in pituitary GH- and PRL-secreting adenomas and in the empty sella syndrome. The circadian rhythms of plasma GH and plasma PRL were abolished respectively in GH- and PRL-secreting pituitary tumors, and they were again detectable after selective transsphenoidal adenomectomy. In the empty sella syndrome only the chrono-organization of GH secretion was disturbed, whereas plasma PRL exhibited the usual circadian pattern. A normal circadian rhythmicity of plasma cortisol was demonstrable in the 3 groups of patients. The diagnostic significance of the chronobiological findings obtained is discussed.
D015065:17-Hydroxycorticosteroids / Q000652:urine; D000236:Adenoma / Q000503:physiopathology*; D000293:Adolescent; D000328:Adult; D001831:Body Temperature; D002940:Circadian Rhythm; D004652:Empty Sella Syndrome / Q000503:physiopathology*; D005260:Female; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000503:physiopathology*; D011388:Prolactin / Q000097:blood / Q000378:metabolism*
D015065:17-Hydroxycorticosteroids; D011388:Prolactin; D013006:Growth Hormone; D006854:Hydrocortisone