SAH analogs, modified in the aminoacid region, inhibitors of phosphatidyl-ethanolamine methylase activity and 3H-SAH binding to rat brain membranes.
The study of phosphatidylethanolamine methylase inhibition by 10 SAH analogs points out the importance of the L-homocysteine amino and carboxylic groups and the sulfur atom for the activity of SAH. Besides, the inhibition of phosphatidylethanolamine methylase by SAH analogs is correlated with their affinity for the 3H-SAH binding sites on the rat cortical membranes.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D006710:Homocysteine / Q000031:analogs & derivatives*; D066298:In Vitro Techniques; D008780:Methyltransferases / Q000037:antagonists & inhibitors*; D050918:Phosphatidylethanolamine N-Methyltransferase; D051381:Rats; D012435:S-Adenosylhomocysteine / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014316:Tritium
D006710:Homocysteine; D014316:Tritium; D012435:S-Adenosylhomocysteine; D008780:Methyltransferases; D050918:Phosphatidylethanolamine N-Methyltransferase