[Action of Bordetella pertussis vaccine on mouse hematopoietic stem cells].
Intravenous inoculation of killed Bordetella pertussis vaccine into BALB/c, CBA, C57Bl/6 mice or (CBA x C57Bl/6) F2 hybrids 1 day or 3 days before sublethal irradiation (5.5 Gy) was shown to sharply increase the endogenous colony formation in the spleen 9 days after irradiation. Moreover, the CFUs content of the spleen and bone marrow was also enhanced 1 and 3 days after vaccination of the mice with 10(10) cells B. pertussis as revealed by the exocolonization technique (Till and McCulloch). Thus, a single injection of B. pertussis vaccine hastened the hematopoietic recovery after irradiation.
D000818:Animals; D003114:Colony-Forming Units Assay; D004306:Dose-Response Relationship, Immunologic; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000276:immunology; D007114:Immunization; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010567:Pertussis Vaccine / Q000276:immunology*; D013997:Time Factors
D010567:Pertussis Vaccine
Deĭstvie vaktsiny Bordetella pertussis na stvolovye krovetvornye kletki mysheĭ.