Pattern VEP in two immunochemical subtypes of optic neuritis.
Visual functions and visual evoked potentials (VEP) were compared in 2 groups of patients with optic neuritis (ON). The subdivision was based on the occurrence of oligoclonal IgG in the cerebrospinal fluid in some patients [the ON (+) group] but not in others [the ON (-) group]. At the onset of ON there were no other signs of neurological disease in these patients. Later the majority of those in the ON (+) group had developed multiple sclerosis but only one patient in the ON (-) group. Recovery after the acute optic inflammation was the same in both groups with respect to visual acuity and fields, but better in the ON (-) than in the ON (+) group with respect to colour vision and pattern VEP. A closer correlation between colour vision defects and VEP latency changes was found for the ON (+) than the ON (-) group, suggesting demyelinating disease as a more probable cause of the optic nerve inflammation in the former than in the latter group.
D000293:Adolescent; D000328:Adult; D003118:Color Perception; D005074:Evoked Potentials, Visual; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D009902:Optic Neuritis / Q000175:diagnosis* / Q000276:immunology; D014792:Visual Acuity; D014794:Visual Fields
D007074:Immunoglobulin G