Acute toxicity of prostaglandin Bx in male, albino, ICR mice.
Median lethal doses were estimated for PGBx administered to mice by the intraperitoneal and intravenous routes. The incidence of lethality (and therefore the LD50) was time dependent over a 96 hour period. The animals were active, were responsive and took nourishment during the 4-day post-injection period so that they apparently died from the direct effects of PGBx (or its metabolites) and not as a consequence of depression-induced dehydration or starvation.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009422:Nervous System Diseases / Q000139:chemically induced; D010085:Oxidative Phosphorylation / Q000187:drug effects; D011108:Polymers / Q000633:toxicity*; D011453:Prostaglandins / Q000633:toxicity*; D011456:Prostaglandins B / Q000633:toxicity*; D013997:Time Factors
D011108:Polymers; D011453:Prostaglandins; D011456:Prostaglandins B; C024303:prostaglandin Bx