Enhanced platelet turnover and prostaglandin production in spontaneously hypertensive rats.
The anti-hypertensive effect of ketanserin, a selective 5-HT2 antagonist, both in experimental and human pathology (1,2) could implicate the blood platelets as a source for peripherally available 5-hydroxytryptamine (5-HT), acting to increase peripheral vascular resistance (3). Therefore we examined various blood platelet parameters in spontaneously hypertensive rats in comparison with normotensive Wistar rats.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001792:Blood Platelets / Q000378:metabolism*; D004906:Erythrocyte Count; D006400:Hematocrit; D006973:Hypertension / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D010976:Platelet Count; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D011453:Prostaglandins; D008315:Malondialdehyde; D001241:Aspirin