[Formation of aberrant polyploid hepatocytes in exposure to the alkylating preparation dipin and to stimulation of proliferation].
One month after the treatment of mice with the alkylating drug Dipin followed by partial hepatectomy 4.7--35.1% of hepatocytes with micronuclei and nuclear bridges in liver were registered. The ploidy level sharply increased. Aberrant cells were the most polyploid ones (16c, 32c). The DNA-fuchsin content in these aberrant polypolid cells decreased by 10--15% due to degrading and non-replication of DNA in the micronuclei.
D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D001388:Aziridines / Q000494:pharmacology*; D001389:Azirines / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival; D002869:Chromosome Aberrations; D006498:Hepatectomy; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011123:Polyploidy; D013997:Time Factors
D000477:Alkylating Agents; D001388:Aziridines; D001389:Azirines; C007526:dipin
Obrazovanie aberrantnykh poliploidnykh gepatotsitov pri deĭstvii alkiliruiushchego preparata dipina i stimuliatsii proliferatsii.