The nonlinear tissue-binding character of fluoride kinetics in normal and anephric subjects. Graphical analysis of serum fluoride data from man and rabbit.
A study has been made of the fluoride kinetics in man, with a series of 5 healthy subjects and 4 patients with renal insufficiency. The fluoride metabolism was found to conform to nonlinear tissue-binding kinetics. Reanalysis of findings on the rabbit reported in the literature yielded equivalent results. The tissue-binding constants elicited - probably associated with the fluoride metabolism of bone - presented no differences between healthy subjects and uremics. Uremics had a clearly lower fractional fluoride elimination rate (K) compared with the healthy controls. A significant correlation of creatinine clearance on the K value was noted.
D000328:Adult; D000368:Aged; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D005260:Female; D005459:Fluorides / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D008954:Models, Biological; D009392:Nephrectomy; D011817:Rabbits
D005459:Fluorides