[Electrophysiological action of disopyramide].
The paper presents data on an electrophysiologic action of disopiramid injected intravenously in a dose of 2 mg/kg on the function of the atrioventricular conduction system in 11 patients with paroxysmal supraventricular tachycardias. Disopiramid reduced the length of the spontaneous cardiac cycle and slightly affected the corrected sinus node recovery time and sinoatrial conduction time. The drug prolonged the intraatrial conduction time, increased the refractoriness of the His-Purkinje system and accessory conduction pathways. It produced no significant action on the refractory period and the function of the A-V node.
D000293:Adolescent; D000328:Adult; D001281:Atrial Fibrillation / Q000188:drug therapy / Q000503:physiopathology; D006328:Cardiac Catheterization; D004206:Disopyramide / Q000627:therapeutic use*; D004341:Drug Evaluation; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011725:Pyridines / Q000627:therapeutic use*; D013614:Tachycardia, Paroxysmal / Q000188:drug therapy / Q000503:physiopathology; D014927:Wolff-Parkinson-White Syndrome / Q000188:drug therapy / Q000503:physiopathology
D011725:Pyridines; D004206:Disopyramide
Elektrofiziologicheskoe deĭstvie dizopiramida.