Food and water intake following injection of glucose into the lateral ventricle of the brain of broiler type chicks.
The effects of glucose and 2-deoxy-D-glucose (2-DG) on food intake and water consumption were investigated in broiler chicks. Artificial cerebrospinal fluid (aCSF) containing either glucose or the glucose antimetabolite 2-DG was injected into the lateral brain ventricles of fasted and satiated chicks. The satiated chicks received 10 microliters of CSF containing either 5 or 10% 2-DG, whereas those fasted for 24 hr received CSF with 10, 20, or 30% glucose (dextrose) in 10 microliters volumes. Chicks were maintained in a thermoneutral environment with continuous lighting. Intraventricular injections of 5 or 10% 2-DG had no significant effect on food intake or water consumption in the fully-fed chicks. In the 24-hr fasted chicks, 10% glucose had no effect on food or water intake. The decrease in food intake observed following the injection of 20 and 30% glucose appeared to be an osmotic effect. Based on results obtained, it was suggested that selection for increased growth rate, such as in broilers, may have resulted in a decrease in glucoreceptor sensitivity. Such a decrease in sensitivity could lead to an increased food intake as occurs in broilers.
D000818:Animals; D002645:Chickens / Q000502:physiology*; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000008:administration & dosage / Q000494:pharmacology*; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D005690:Galactose / Q000494:pharmacology; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular / Q000662:veterinary; D008297:Male; D008757:Methylglucosides / Q000494:pharmacology; D009995:Osmosis
D003837:Deoxy Sugars; D008757:Methylglucosides; C027020:methylglucoside; D003847:Deoxyglucose; D005947:Glucose; D005690:Galactose