Influence of oral supplementation of ascorbate upon the induction of N-methyl-N'-nitro-N-nitrosoguanidine.
Influence of mega-ascorbate (AsA) intake upon the induction of gastric cancer of rats was investigated. By feeding the ascorbate-supplemented diet, though the incidence of gastric cancer was not effectively inhibited, the infiltrative growth was significantly repressed. Mega-ascorbate intake was more beneficial in alleviating the development of gastric cancer when it was commenced after the middle of long-term experimental period (initiation of adenomatous hyperplasia but no appearance of malignant lesions) rather than from the beginning of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) drinking. A remarkable effect of mega-ascorbate intake was to reinforce the surrounding connective tissues to retard the malignant growth.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D003043:Cocarcinogenesis; D003238:Connective Tissue / Q000187:drug effects / Q000473:pathology; D004032:Diet; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology
D008769:Methylnitronitrosoguanidine; D001205:Ascorbic Acid