[Morphological changes in the hematopoietic organs and the pancreas in experimental exposure to 5-fluorouracil].
Experiments on 30 dogs were performed to study the effect of intraperitoneal irrigation with 5-fluorouracil on the morphology of the pancreas and on the hemopoietic organs. The drug was administered to the abdominal cavity via a catheter in a dose of 5 mg/kg bw for 2, 3 and 5 days. Morphological study revealed no dystrophic or necrobiotic processes in the pancreas, spleen and bone marrow of the animals.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D004285:Dogs; D005472:Fluorouracil / Q000494:pharmacology*; D006413:Hematopoietic System / Q000187:drug effects* / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D010179:Pancreas / Q000187:drug effects* / Q000473:pathology; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013997:Time Factors
D005472:Fluorouracil
Morfologicheskie izmeneniia krovetvornykh organov i podzheludochnoĭ zhelezy pri deĭstvii 5-ftoruratsila v éksperimente.