Deposition pattern of the antifertility agent, gossypol, in selected organs of male rats.
Male rats received daily, oral doses of gossypol-acetate (40 mg/kg body wt) for 2, 4, or 8 weeks to determine patterns of gossypol deposition in the spleen, liver, heart, kidneys, lungs, and testes during establishment of a gossypol-induced infertility. Infertility was exhibited at the end of the 4-week dosing period. Free and bound gossypol accumulated in all of the organs.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005298:Fertility / Q000187:drug effects; D006072:Gossypol / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D006072:Gossypol