[Therapeutic effectiveness of diethyxime in poisoning by anticholinesterase-action carbamate pesticides].
Unlike dipyroxime (10 mg/kg), a new cholinesterase reactivator diethyxime (20 mg/kg) exerts a therapeutic action in acute poisoning of rats with carbamine pesticides (carbofuran, elocron, pirimor, croneton). Therapy with diethyxime combined with atropine (at a rate of 10 mg/kg) leads to the summation of therapeutic effects. At the same time the toxicity of carbofuran, pirimor, croneton and elocron as regards the LD50 decreases 8.75-fold, 5.4-, 4- and 2,84-fold, respectively. The mechanism of the therapeutic action of diethyxime is determined by its capacity to recover cholinesterase activity both in the peripheral and central nervous systems, as well as to normalize neuromuscular transmission. It is necessary to take into account the cholinolytic effect displayed by diethyxime.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001285:Atropine / Q000627:therapeutic use; D002219:Carbamates; D002801:Cholinesterase Reactivators / Q000627:therapeutic use*; D002802:Cholinesterases / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D007306:Insecticides / Q000506:poisoning*; D009132:Muscles / Q000187:drug effects; D010091:Oximes / Q000627:therapeutic use*; D051381:Rats; D014289:Trimedoxime / Q000627:therapeutic use
D002219:Carbamates; D002801:Cholinesterase Reactivators; D007306:Insecticides; D010091:Oximes; C012284:diethyxime; D014289:Trimedoxime; D001285:Atropine; D002802:Cholinesterases
Terapevticheskaia éffektivnost' dietiksima pri otravlenii karbaminovymi pestitsidami antikholinésteraznogo deĭstviia.