[Effect of bivalent copper ions on the catalytic properties of bovine liver glutamate dehydrogenase].
The effects of bivalent copper ions on the activity of bovine liver glutamate dehydrogenase (L-glutamate NAD (P) oxidoreductase, EC 1.4.1.3) were studied. Cu2+ effectively interacts with the enzyme; this interaction is accompanied by a loss of the enzyme activity in the reaction of reductive amination of alpha-ketoglutarate. The data obtained are indicative of a similar type of the enzyme inhibition by GTP and copper ions.
D000818:Animals; D002417:Cattle; D003300:Copper / Q000494:pharmacology*; D005969:Glutamate Dehydrogenase / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D011485:Protein Binding; D013056:Spectrophotometry, Ultraviolet
D003300:Copper; D005969:Glutamate Dehydrogenase
Vliianie dvukhvalentnogo iona medi na katalitichskie svoistva glutamatdegidrogenazy pecheni byka.