Pharmacological responsiveness of sweat glands in anxious patients and healthy volunteers.
The responsiveness of eccrine sweat glands to local intradermal injections of carbachol and phenylephrine was studied in six male and six female healthy volunteers and six female patients suffering from anxiety neurosis, using a plastic paint impression method. Carbachol evoked consistently greater responses than phenylephrine. The response to carbachol attained a peak approximately two minutes after injection, whereas the response to phenylephrine attained a peak within fifteen seconds of the injection. Males showed greater responsiveness to both drugs than females, this being reflected in significantly higher maxima of the dose-response curves for the males. The anxious females showed a higher level of spontaneous sweat gland activity and greater responsiveness to both drugs (reflected in higher maxima of the dose-response curves) than the normal females.
D000328:Adult; D001008:Anxiety Disorders / Q000503:physiopathology*; D002217:Carbachol / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology*; D012737:Sex Factors; D013545:Sweat Glands / Q000187:drug effects*
D010656:Phenylephrine; D002217:Carbachol