[Severe intoxication after combined chemotherapy of a sigma-adenocarcinoma with peptichemio and 5-fluorouracil (author's transl)].
After perioperative adjuvant chemotherapy of a sigma-adenocarcinoma with 400 mg peptichemio and 500 mg 5-fluorouracil a 61-year-old woman developed a severe intoxication: myelosuppression with pancytopenia, gastroenteritis and ulcerative proctitis, toxic hepato- and myocardiopathy, impaired renal function and alopecia. As a result of reduced resistance pneumonias, urinary tract infection, sepsis, cytomegaly infection and candidiasis of the oral mucosa occurred. The toxic effects are attributed mainly to the high dose of peptichemio.
D000230:Adenocarcinoma / Q000188:drug therapy*; D000505:Alopecia / Q000139:chemically induced; D002180:Candidiasis, Oral / Q000139:chemically induced; D003967:Diarrhea / Q000139:chemically induced; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects* / Q000627:therapeutic use; D006529:Hepatomegaly / Q000139:chemically induced; D006801:Humans; D008558:Melphalan / Q000031:analogs & derivatives*; D008875:Middle Aged; D010440:Peptichemio / Q000009:adverse effects* / Q000627:therapeutic use; D012811:Sigmoid Neoplasms / Q000188:drug therapy*
D010440:Peptichemio; D008558:Melphalan; D005472:Fluorouracil
Schwere Intoxikation nach kombinierter Chemotherapie eines Sigma-Adenokarzinoms mit Peptichemio und 5-Fluorouracil.