Fluctuating dystonia and allied syndromes.
Dystonia musculorum deformans is a descriptive diagnosis. A number of other conditions such as Hallervorden-Spatz disease and juvenile paralysis agitans have to be excluded. Then the history of a child's illness may suggest a particular syndrome such as the progressive dystonia with marked diurnal fluctuations. Two case reports are given of children who show fluctuation of symptoms but their histories varied from those previously described. Problems of treatment are discussed and it is suggested that fluctuation of symptoms may indicate a response to levadopa while those with a relentless progression of symptoms may respond to other drugs such as orphenadrine.
D002648:Child; D003937:Diagnosis, Differential; D004421:Dystonia / Q000175:diagnosis; D004422:Dystonia Musculorum Deformans / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male
D007980:Levodopa