Sulindac hepatotoxicity.
Two patients who developed painless jaundice while taking sulindac are described. Rechallenge in one case confirmed the association of hepatic damage with sulindac administration. Laboratory data and liver biopsy findings suggested a hepatitis with cholestatic features.
D000368:Aged; D002779:Cholestasis / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D007192:Indenes / Q000009:adverse effects*; D007565:Jaundice / Q000139:chemically induced* / Q000473:pathology; D008099:Liver / Q000473:pathology; D013467:Sulindac / Q000009:adverse effects*
D007192:Indenes; D013467:Sulindac