[Study of histoenzymologic signs of selective neuronal hyperactivity].
Injection of kainic acid into the cerebellum leads to a neuroexcitatory and neurotoxic effect on neurons connected with cerebellar granule cells. Observation of the activities of dehydrogenases taking part in glucose metabolism and glutamate dehydrogenase shows that Purkinje cells undergo a rapid destruction. Lesions of small stellate cells come later. But the basket cells present a long period of hyperactivity revealed by an increase of dehydrogenase activity.
D000818:Animals; D002531:Cerebellum / Q000187:drug effects* / Q000201:enzymology; D006651:Histocytochemistry; D007608:Kainic Acid / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects* / Q000201:enzymology; D010088:Oxidoreductases / Q000378:metabolism; D011689:Purkinje Cells / Q000187:drug effects; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011759:Pyrrolidines; D010088:Oxidoreductases; D007608:Kainic Acid
A la récherche de signes histoenzymologiques d'une hyperactivité neuronale sélective.