Efficacy of triamcinolone acetonide following neurorrhaphy-an electroneuromyographic evaluation.
A primate model to test the effects of triamcinolone acetonide on reinnervation after neurorrhaphy was developed. Reinnervation was assessed in triamcinolone- and placebo-treated nerves. Twelve months after neurorrhaphy, nerves treated with triamcinolone had a faster conduction velocity; a greater amplitude in the evoked response; more and larger axons distally on cross-sectional histological examination; and an evoked response wave form closely resembling normal. We conclude that triamcinolone acetonide instilled locally about a neurorrhaphy immediately after the repair is beneficial for the regeneration of motor nerves in primates.
D000818:Animals; D004576:Electromyography / Q000295:instrumentation / Q000379:methods; D008251:Macaca; D009046:Motor Neurons / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D009416:Nerve Regeneration / Q000187:drug effects*; D010525:Peripheral Nerves / Q000502:physiology / Q000601:surgery*; D014222:Triamcinolone Acetonide / Q000494:pharmacology*
D014222:Triamcinolone Acetonide