[Benzenedithiol esters with antimycotic activity].
Some diesters of benzen-1,2-dithiol wit aliphatic and aromatic carboxylic acids were prepared and tested for in vitro antifungal activity. The diacetate and dipropionate of benzen-1,3- and 1,4-dithiol were used as comparison compounds. The substances (Table I; substances I leads to X) were obtained by condensation of benzenedithiols with suitable acylating agents. The fungistatic activity of the products was tested in vitro against the following fungal strains: Candida albicans, Candida tropicalis, Saccharomyces cerevisiae and Trichophyton mentagrophytes. The results show that the diester of benzen-1,2-dithiols with alkanoic acids (Table I) have marked antimycotic activity, much greater than that of clotrimazol. The diaroyl esters of benzen-1,2-dithiol and the diesters of benzen-1,3- and 1,4-dithiols are inactive or only slightly active.
D000935:Antifungal Agents / Q000138:chemical synthesis*; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000494:pharmacology
D000935:Antifungal Agents; D001555:Benzene Derivatives; D013438:Sulfhydryl Compounds
Esteri di benzenditioli ad attività antimicotica.