Inequality of clearance values obtained by intravenous bolus and by steady-state infusion. Prednisolone studies in dogs.
In order to compare total and free prednisolone clearance values following an intravenous bolus dose with those following zero-order infusions to steady state, 6 dogs were given an intravenous bolus and four different zero-order infusions of prednisolone. Prednisolone clearance for the infusion studies were calculated by dividing the infusion rate by the steady-state concentration. Time-averaged clearances for the intravenous bolus doses were calculated as dose divided by area under the concentration curve. The total and unbound prednisolone clearance values calculated using the steady-state levels averaged 24 and 39% higher, respectively, than the corresponding clearance values obtained following intravenous bolus dosing.
D000818:Animals; D004285:Dogs; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D008657:Metabolic Clearance Rate; D011239:Prednisolone / Q000008:administration & dosage / Q000378:metabolism*; D013997:Time Factors
D011239:Prednisolone