[Cytomorphological changes in a culture of Streptomyces rimosus, the producer of oxytetracycline, in the presence of different foam retardants].
The data on the effect of chemical foam suppressors of various classes on the morphogenesis of 2 strains of Streptomyces rimosus are presented. Correlation between the age of the culture and its reaction to unfavourable conditions is confirmed. During the first 24 hours of the growth the culture is most sensitive to low aeration rates, addition of the foam suppressors, fat deficiency in the medium. Among the foam suppressors used propinol B-400 had the most significant effect on the cells: destruction of the cell coating, marked changes in the morphogenesis and nucleocytosis of the hyphae of the second generation responsible mainly for the antibiotic biosynthesis. A more active strain was more subject to the foam suppressor toxic effect.
D000934:Antifoaming Agents / Q000494:pharmacology*; D003470:Culture Media / Q000378:metabolism; D008854:Microscopy, Electron; D010118:Oxytetracycline / Q000096:biosynthesis*; D013302:Streptomyces / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D013501:Surface-Active Agents / Q000494:pharmacology*
D000934:Antifoaming Agents; D003470:Culture Media; D013501:Surface-Active Agents; D010118:Oxytetracycline
Tsitomorfologicheskie izmeneniia kul'tury Streptomyces rimosus--produtsenta oksitetratsiklina--v prisutstvii razlichnykh penogasiteleĭ.