Carcinogenicity examination of inflorescence of Zingiber mioga Roscoe.
The carcinogenicity of mioga was examined in ACI and Fischer 344 rats. In Experiment I, a test group of ACI rats received diet containing mioga for 365 days, and the control group received normal basal diet. The experiment was terminated 480 days after the start of feeding. In Experiment II, a test group of Fischer 344 rats received diet containing mioga throughout the experiment of 639 days and the control group received normal diet. Female ACI rats in Experiment I developed significantly more urinary bladder tumors than the control group. No carcinogenic activity was observed in males in Experiment I or males or females in Experiment II.
D000818:Animals; D002273:Carcinogens; D002291:Carcinoma, Papillary / Q000209:etiology*; D002295:Carcinoma, Transitional Cell / Q000209:etiology*; D004032:Diet / Q000009:adverse effects; D005260:Female; D019684:Magnoliopsida; D008297:Male; D051381:Rats; D011912:Rats, Inbred ACI; D011916:Rats, Inbred F344; D012737:Sex Factors; D001749:Urinary Bladder Neoplasms / Q000209:etiology*
D002273:Carcinogens