Comutagenic effect of norharman with aminopyridine derivatives.
The mutagenicities of 3 monoaminopyridines, 4 methyl-substituted monoaminopyridines and 3 diaminopyridines were tested with or without norharman in the Salmonella assay system. None of the compounds was mutagenic without norharman. However, 3-aminopyridine and 2-amino-3-methylpyridine were mutagenic in the presence of norharman and S9 mix; 3-aminopyridine was mutagenic to TA98, but not to TA100, while 2-amino-3-methylpyridine was mutagenic to both TA98 and TA100, although its mutagenicity was much stronger in TA98.
D000470:Alkaloids / Q000494:pharmacology*; D000631:Aminopyridines / Q000494:pharmacology*; D002243:Carbolines; D004357:Drug Synergism; D006247:Harmine / Q000031:analogs & derivatives / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009153:Mutagens
D000470:Alkaloids; D000631:Aminopyridines; D002243:Carbolines; D009153:Mutagens; D006247:Harmine; C010262:norharman