Use of a multichannel analysis profile for the assessment of risk of developing coronary heart disease.
The use of serum total cholesterol: high density lipoprotein cholesterol (TC:HDL-C) is well-established. Because HDL-C measurements are expensive, and cholesterol is part of the multichannel analysis profile, the author attempted to determine whether other parameters which are part of this profile could be useful indicators of the TC:HDL-C ratio. Based on an inverse correlation obtained in healthy men (42-59 years of age) between HDL-C and fasting plasma glucose (r = 0.40, P less than 0.001), triglycerides (r = 0.51, P less than 0.001), and uric acid (r = 0.29, P less than 0.01), a GUT (glucose, uric acid, triglyceride) score was calculated and correlated with the TC:HDL-C ratio (r = 0.86, P less than 0.001). In over 90% of cases the GUT score was able to predict whether an individual was likely to have a TC:HDL-C ratio of less than 4.5 or greater than 4.5. Thus, the GUT score is a useful indicator for an individual who is likely to require a lipid profile which includes HDL-C measurement.
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL; D003327:Coronary Disease / Q000097:blood*; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008875:Middle Aged; D012306:Risk; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000032:analysis
D001786:Blood Glucose; D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D014280:Triglycerides; D014527:Uric Acid; D002784:Cholesterol