[The occurrence of proinsulin and C-peptide in healthy humans and in diabetics].
Chemistry, biochemistry and physiology of proinsulin and C-peptide are summarized. A short characterization of the radioimmunological methods for measuring C-peptide and proinsulin follows. The determination of C-peptide and proinsulin which was mainly carried out in serum or plasma essentially improved our knowledge about the function of the beta-cells in the islets of Langerhans in healthy subjects and diabetic patients. The paper reports on the occurrence and the course of C-peptide and proinsulin in healthy subjects and in diabetics of type I and II.
D000328:Adult; D000595:Amino Acid Sequence; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood*; D002648:Child; D003920:Diabetes Mellitus / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood; D006801:Humans; D010455:Peptides / Q000097:blood*; D011384:Proinsulin / Q000097:blood*; D011863:Radioimmunoassay
D001786:Blood Glucose; D002096:C-Peptide; D010455:Peptides; D011384:Proinsulin
Das Vorkommen von Proinsulin und C-Peptid bei Gesunden und bei Diabetikern.