Thermogenic response to glucagon in cold-acclimated mice.
Heat production after injection of glucagon and norepinephrine was measured in warm- and cold-acclimated mice. Glucagon and norepinephrine in a dose of 100 microgram/100 g caused a marked increase in oxygen consumption. Heat production after administration of glucagon and norepinephrine was significantly potentiated by cold acclimation. A significant positive correlation was observed between the increase in oxygen consumption after injection of glucagon or norepinephrine and the weight of brown adipose tissue in warm- and cold-acclimated mice. These findings indicate that glucagon is a calorigenic hormone in mice and its effect is potentiated by cold acclimation possibly due to an activation of thermogenic mechanism(s) in brown adipose tissue.
D000064:Acclimatization; D002001:Adipose Tissue, Brown / Q000033:anatomy & histology / Q000187:drug effects; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D003080:Cold Temperature; D005934:Glucagon / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009638:Norepinephrine / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects
D005934:Glucagon; D009638:Norepinephrine