[Mesothelial reaction to irritation].
Autopsy cases of fibrinous pericarditis were studied in different stages of granulation tissue organization. Flat mesothelium grew higher and hyperplastic, lining the holes in fibrin network and desquamating at the same time. Single rounded mesothelial cells shed into free space and acquired an atypical appearance of big monocytoid cells with nuclear hyperchromasia and sometimes with nucleoli. As the organization developed further, the mesothelial cells produced gland-like structures enveloped in edematous granulation tissue pervaded with inflammatory cells. Mesothelial lesions due to chronic inflammatory irritation were also evidenced by cases of chronic adnexitis. The mesothelial cells showed an ability to simulate invasive growth in abundant fibrous stroma as gland-like, papillary and pseudoinfiltrative structures lined with cuboid, columnar, stratified, mucogenic and metaplastic squamous epithelium. Proliferating mesothelial cells might suggest tumourous character; in some cases they could not be distinguished from mesothelioma or from secondaries of adenocarcinoma.
D004848:Epithelium / Q000473:pathology; D005187:Fallopian Tubes / Q000473:pathology*; D005260:Female; D006097:Granulation Tissue / Q000473:pathology; D006801:Humans; D010493:Pericarditis / Q000473:pathology*; D010496:Pericardium / Q000473:pathology*; D012488:Salpingitis / Q000473:pathology*
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