[Effect of the times of remantadine administration on its content in MDCK cells and white mouse lung tissues infected and uninfected with the influenza virus].
Remantadine distribution in the cell-nutrient medium and in experimental animals was studied. Differences in the penetration and content of remantadine in the MDCK cells and lungs of intact and influenza virus-infected white mice were demonstrated. The content of remantadine in these systems depended on the time of its administration. When remantadine was added into intact cultures or in cultures infected with influenza virus 1 h after remantadine inoculation, its content in the cells was similar, about 40% of that added to the culture medium. If remantadine was added to previously infected culture, its content in the cells was considerably lower. Similar results were obtained in experimental white mice.
D000218:Adamantane / Q000031:analogs & derivatives*; D000818:Animals; D003470:Culture Media / Q000378:metabolism; D008168:Lung / Q000378:metabolism* / Q000382:microbiology; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000378:metabolism* / Q000382:microbiology; D012299:Rimantadine / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution; D014776:Virus Cultivation
D003470:Culture Media; D012299:Rimantadine; D000218:Adamantane
Vliianie srokov vvedeniia remantadina na ego soderzhanie v zarazhennykh i ne zarazhennykh virusom grippa kletkakh MDCK i v tkaniakh legkikh belykh mysheĭ.