[Effect of triterpene glycosides on the stability of bilayer lipid membranes, containing different sterols].
Low concentrations of triterpene glycosides: holothurin A, stichoposide A and cauloside C sharply change the stability of bilayer lipid-sterine membranes. The glycosides activity decreases in the line: holothurin A, stichoposide A, cauloside C. The effective doses of glycosides are to a great extent determined by structural peculiarities of sterines which compose the films. A correlation was observed between the effect of triterpene glycosides on the stability of model bilayer membranes and their physiological activity. The model lipid-sterine membranes can be used in the primary screening of triterpene glycosides to estimate their physiological activity.
D004355:Drug Stability; D006027:Glycosides; D006697:Holothurin / Q000031:analogs & derivatives; D007700:Kinetics; D008051:Lipid Bilayers; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D012502:Sapogenins; D012503:Saponins; D013329:Structure-Activity Relationship; D014315:Triterpenes
D006027:Glycosides; D008051:Lipid Bilayers; D012502:Sapogenins; D012503:Saponins; D014315:Triterpenes; D006697:Holothurin; C036411:cauloside A; C034723:holothurin A; C001883:stichoposide; D009828:Oleanolic Acid
Vliianie triterpenovykh glikozidov na stabil'nost' bisloĭnykh lipidnykh membran, soderzhashchikh razlichnye steriny.