Superior colliculus activation by retinal nicotinic ganglion cells: a 2-deoxyglucose study.
Systemic injection of the acetylcholinesterase inhibitor, di-isopropylfluorophosphate, in rats causes a marked increase in glucose use in the superficial layers of the superior colliculus. This activation of the superior colliculus is largely a retinal effect. Furthermore, since this response can be blocked by intraocular as well as systemic injections of mecamylamine, it is postulated that retinal nicotinic receptors are involved.
D000818:Animals; D003847:Deoxyglucose / Q000378:metabolism; D007531:Isoflurophate / Q000494:pharmacology; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011950:Receptors, Cholinergic / Q000502:physiology*; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000502:physiology*; D012160:Retina / Q000502:physiology*; D013477:Superior Colliculi / Q000187:drug effects / Q000502:physiology*
D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic; D007531:Isoflurophate; D008464:Mecamylamine; D003847:Deoxyglucose