Topical 5-fluorouracil treatment of transformation zone intraepithelial neoplasia of cervix and vagina.
The authors present preliminary findings in 11 unselected patients with upper vaginal and/or cervical transformation zone intraepithelial neoplasia treated with a 5% topical 5-fluorouracil (5-FU) cream. Only 6 of 11 patients were found to be cured of disease when subsequently evaluated histologically by conization biopsy and/or hysterectomy. Although further clinical trials using differing concentrations and/or more prolonged exposure to the drug may be warranted, the authors cannot recommend topical 5-FU as a replacement for standard outpatient therapy for upper vaginal and/or cervical intraepithelial neoplasia.
D000287:Administration, Topical; D002278:Carcinoma in Situ / Q000188:drug therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D002578:Uterine Cervical Dysplasia / Q000188:drug therapy; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014625:Vaginal Neoplasms / Q000188:drug therapy* / Q000473:pathology
D005472:Fluorouracil