Genetic evidence for the inactivation of a human autosomal locus attached to an inactive X chromosome.
Mouse-human cell hybrid clones retaining an inactive translocated chromosome involving the human X and 13 were isolated. Esterase D, a marker on the segment of chromosome 13 translocated to the X, was not expressed in these clones. These results provide genetic evidence for the spreading of inactivation into the autosomal segment in an inactive human X-autosome translocation.
D000818:Animals; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000235:genetics; D002460:Cell Line; D002901:Chromosomes, Human, 13-15; D002999:Clone Cells / Q000201:enzymology; D004303:Dosage Compensation, Genetic; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells / Q000201:enzymology; D051379:Mice; D012730:Sex Chromosomes; D014178:Translocation, Genetic; D014960:X Chromosome
D005954:Glucosephosphate Dehydrogenase; D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase; C020118:ESD protein, human