The pharmacokinetics and bioavailability of mebendazole in man: a pilot study using [3H]-mebendazole.
Following the intravenous administration of a tracer dose (1.7 microgram) of [3H]-mebendazole to a man, an elimination half-life of 1.16 h was observed and the volume of distribution was calculated to be 2.03 l/kg. After oral administration of the same dose, an elimination half-life of 0.74 h was observed. The bioavailability of mebendazole from the solution was found to be 17%.
D001562:Benzimidazoles / Q000378:metabolism*; D001682:Biological Availability; D006801:Humans; D007700:Kinetics; D008297:Male; D008463:Mebendazole / Q000378:metabolism*; D014316:Tritium
D001562:Benzimidazoles; D014316:Tritium; D008463:Mebendazole