[Treatment experiments with glucose-induced hyperglycaemia plus Clostridium-spores on the Jensen sarcoma of rats].
Investigations Jensen's sarcoma-bearing Wistar rats demonstrate the possibility to increase significantly the oncolytic effect of an apathogenic strain of Clostridium butyricum (5 x 10(8) spores of Cl. oncolyticum M 55 i.v.) by an artificial short time hyperglycaemia (achieved maximum blood level of glucose 28.87 +/- 8.05 mmol/l). The most impressive effect was observed after a repeated application of this combination at a distance of 7 days. Both the hyperglycaemia and the application of spores have a high tumour selectivity and a relatively good compatibility. The consequence for estimations of the LDH-, ALAT- and ASAT-activity in the judgment of the therapeutical tumours damage rate is discussed.
D000496:Alloxan / Q000008:administration & dosage; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003013:Clostridium / Q000276:immunology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000201:enzymology / Q000378:metabolism / Q000628:therapy*; D013171:Spores, Bacterial / Q000276:immunology
D001786:Blood Glucose; D000496:Alloxan
Therapieversuche mit glukoseinduzierter Hyperglykämie und Clostridien-Sporen am Jensen-Sarkom der Ratte.