Treating geriatric depression: a 26-week interim analysis.
Two concurrent studies of geriatric outpatients who received diagnoses of depression were conducted. In the first, patients were treated with one of two tricyclic antidepressants or with a placebo. In the second, patients were assigned to groups receiving either psychodynamic group therapy or cognitive-behavioral group therapy. Patients in the placebo group showed the least improvement; most patients receiving group psychotherapy showed some improvement, but only 12% had full remissions; by contrast, 45% of patients receiving imipramine or doxepin had full remissions, while 36% of them experienced little or no benefit. An early response to tricyclic antidepressant drugs was a reliable predictor of continued improvement.
D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D001521:Behavior Therapy; D003071:Cognition; D003866:Depressive Disorder / Q000188:drug therapy / Q000628:therapy*; D004311:Double-Blind Method; D004316:Doxepin / Q000627:therapeutic use; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D008875:Middle Aged; D011615:Psychotherapy, Group
D000929:Antidepressive Agents, Tricyclic; D004316:Doxepin; D007099:Imipramine