[Synthesis and antibacterial and antitumoral activity of some methylhydrazonium salts of pyrimidine bases and their analogues (author's transl)].
On reacting pyrimidine metabolites containing a carboxyl or sulfhydryl group with methylhydrazine or N-benzyl-N'-methylhydrazine, various methylhydrazonium salts of these metabolites were synthetized, e.g., the salts of 5-fluororotic acid, 5-azaorotic acid, 2-thiouracil-5-carboxylic acid and 2-thio-6-azathymine. Some of these salts exhibited a more marked antibacterial activity against St. aureus and several of its mutants as well as a greater antitumoral activity against different transplantable tumours than their single components.
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D011743:Pyrimidines
Synthese, antibakterielle und geschwulsthemmende Wirkung einiger Methylhydrazoniumsalze von Pyrimidinbasen und deren Analoga.