Effect of aminoglycoside antibiotics on the contractility of the uterus.
In the present study the inhibitory effect of five aminoglycoside antibiotics on the contractility of rat uterus was investigated. We found that all the antibiotics tested inhibited the contractility of the isolated rat uterus and only quantitative differences existed among them. The inhibitory potency of the aminoglycoside antibiotics appears to be as follows: sisomicin greater than gentamicin greater than tobramycin greater than dibekacin greater than amikacin. Calcium not only has the ability to restore the normal contractility of the uterus but also to exert protective action against the inhibitory effect of aminoglycoside antibiotics on the uterus contractility.
D000617:Aminoglycosides / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002122:Calcium Chloride / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014590:Uterine Contraction / Q000187:drug effects*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002122:Calcium Chloride