Niridazole and fertility in bilharzial men.
The antispermatogenic effect of niridazole was studied in 20 bilharzialmale patients. Niridazole was found to induce defective spermatogenesis in the form of focal spermatocyte arrest and or germinal cell hypoplasia. The effect was transient, with active recovery occurring 3 months after therapy. Niridazole therapy must be postponed or changed for those subjects whose semen parameters prove to be subfertile.
D001706:Biopsy; D005298:Fertility / Q000187:drug effects*; D006801:Humans; D008297:Male; D009560:Niridazole / Q000627:therapeutic use*; D012552:Schistosomiasis / Q000188:drug therapy*; D013091:Spermatogenesis / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects / Q000473:pathology; D013737:Testis / Q000187:drug effects / Q000473:pathology
D009560:Niridazole