[Effect of nalorphine and naloxone on the course of electric pain shock in rabbits].
Electrical stimulation of the rabbit sciatic nerve resulted in the development of shock. Injection of physiological saline (1 ml, i. v.) did not change the progressive fall of the blood pressure or depression of palpitation and respiration. The animals died 135--191 min after discontinuance of the stimulation. Injection of nalorphine (0.4 mg/kg, i. v.) or naloxone (0.1 mg/kg i. v.) greatly improved the animals' condition. The blood pressure, palpitation and respiration returned to normal in 90--120 min after the injections. No lethal cases were recorded in this group of animals. It was shown in a supplementary group of animals that naloxone did not change the reserpine-produced hypotension.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004597:Electroshock / Q000401:mortality; D009269:Nalorphine / Q000627:therapeutic use*; D009270:Naloxone / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy* / Q000401:mortality; D011817:Rabbits; D012769:Shock / Q000188:drug therapy* / Q000401:mortality; D013997:Time Factors
D009270:Naloxone; D009269:Nalorphine
Vliianie nalorfina i naloksina na techenie élektrobolevogo shoka u krolikov.