Some new 2-aryloxymethyl-3-alpha-substituted carboxymethyl-6,8-substituted-4-quinazolones as possible anticonvulsants.
In view of their expected MAO inhibitory, CNS depressant and anticonvulsant properties, thirty new 2-aryloxymethyl-3-alpha-substituted carboxymethyl-6,8-substituted-4-quinazolones were synthesized by the reaction of substituted anthranil with various amino acids in pyridine. Some of these compounds at a concentration of 1 X 10(-3) mol/l inhibited rat brain monamine oxidase (MAO) in vitro and provided protection against pentylenetetrazole induced convulsions in mice.
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D001522:Behavior, Animal / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology
D000927:Anticonvulsants; D008996:Monoamine Oxidase Inhibitors; D011799:Quinazolines