[Oxidative phosphorylation and the activity of the polyenzyme systems of rat liver mitochondrial membranes in starvation].
The rate of mitochondrial phosphorylation, evaluation by coefficient of respiratory control and the ratio ADP/O, was decreased as a result of lowering in the rate of phosphorylation and DNP-stimulated oxidation, occurred in rat liver tissue under conditions of long-term starvation (5 days) as compared with control animals. In starvation rat liver mitochondria were most distinctly impaired by high temperature, phospholipase A2 and trypsin. Latent destructions, formed in mitochondrial membranes, were responsible for high lability of the organelles in starvation. In long-term starvation incorporation of exogenous cytochrome c into mitochondrial membrane was impaired also due to deterioration in structural relationship between phospholipids and protein of the membrane.
D000818:Animals; D007425:Intracellular Membranes / Q000201:enzymology; D007656:Ketoglutaric Acids / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010741:Phospholipases A / Q000494:pharmacology; D054467:Phospholipases A2; D051381:Rats; D013217:Starvation / Q000201:enzymology*; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid; D013997:Time Factors; D014357:Trypsin / Q000494:pharmacology
D007656:Ketoglutaric Acids; D013386:Succinates; D019802:Succinic Acid; D009247:NADH, NADPH Oxidoreductases; D010741:Phospholipases A; D054467:Phospholipases A2; D014357:Trypsin
Okislitel'noe fosforilirovanie i aktivnost' polifermentnykh sistem membran mitokhondriĭ pecheni krys pri golodanii.