PHA induced blastoid transformation of lymphocytes in leprosy contacts.
PHA-induced blastoid transformation of lymphocytes was studied in 29 contacts of leprosy patients. 21 contacts taking DDS as prophylaxis showed significant depression of lymphocyte transformation while 8 contacts not taking DDS showed no depression as compared to controls. DDS thus has an inhibitory effect on cell mediated immune response.
D003622:Dapsone / Q000627:therapeutic use*; D006801:Humans; D007918:Leprosy / Q000188:drug therapy / Q000276:immunology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D010835:Phytohemagglutinins / Q000494:pharmacology*
D010835:Phytohemagglutinins; D003622:Dapsone