[Influence of steroid hormones on drug disposition? Experiments with acetylruthenocene in mice and rats].
After injection of acetyl-[103Ru]-ruthenocene, high 103Ru concentration are found in adrenals of female mice. This was also found with acetyl-[3H]ruthenocene. On autoradiography only the adrenal cortex, not the medulla, was labelled. High 103Ru accumulations did not occur in the adrenals of male mice or rats, but male rats exhibited a very high 103Ru concentration in the kidney, with concentration kidney/muscle ratios up to 780:1. The 103Ru-concentration in the kidney of female rats was only 1/20 that of male rats. After application of testosterone propionate to female mice or estradiol to male rats a drastic change in organ distribution was observed: the 103Ru radioactivity in adrenals and kidneys decreased by a factor of 15. Similar to these results obtained with acetylruthenocen, a sex-specific distribution, but to a lesser extent, was found with dihydroacetylruthenocens.
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D005260:Female; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008297:Male; D051379:Mice; D009132:Muscles / Q000378:metabolism; D009942:Organometallic Compounds / Q000378:metabolism*; D011868:Radioisotopes; D051381:Rats; D011919:Rats, Inbred Strains; D012428:Ruthenium / Q000378:metabolism*; D012737:Sex Factors; D013045:Species Specificity; D014018:Tissue Distribution; D014316:Tritium
D009942:Organometallic Compounds; D011868:Radioisotopes; D014316:Tritium; C016199:acetylruthenocene; D012428:Ruthenium
Einfluss von Sexualhormonen auf die Pharmakaverteilung? Versuche mit Acetylruthenocen bei Ratten und Mäusen.