Histological classification of resorbed bone.
A histological classification of resorbed bone is reported in this paper. The materials used were 426 human bones in autopsy and surgical cases, ranging from 3-month-od fetus to 95-year-old. The resorbed bones were divided into osteoclasis (osteoclastic resorption) and osteolysis (non-osteoclastic resorption). Osteoclasis was observed in the cases of development, growth, active stage of granulation tissue, and inflammation, and some cases of malignant tumor invasion. Osteolysis was observed in the cases of senile atrophy, osteoporosis, ischemia, radiation damage, hormonal and chemical effects, non-active stage of granulation tissue and inflammation, and some cases of malignant tumor invasion. Based on these findings, human resorbed bones can be classified into three histological types: rapid, slow, and static. Such a classification could be certified through the results of animal experiments. A possibility exists that osteoclasis occurs in rapid resorption and osteolysis is in slow and static resorption. Furthermore, it is suggested that osteoclasis is passive resorption and osteolysis is autolysis.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D000539:Alveolar Process / Q000473:pathology; D000818:Animals; D001847:Bone Diseases / Q000473:pathology; D001862:Bone Resorption / Q000145:classification / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008252:Macaca fascicularis; D008297:Male; D008875:Middle Aged; D010010:Osteoclasts / Q000473:pathology; D010014:Osteolysis / Q000473:pathology; D011247:Pregnancy