Salvage chemotherapy for non-Hodgkin's lymphoma.
Nineteen patients with advanced non-Hodgkin's lymphoma resistant to previous chemotherapy were treated with combination chemotherapy consisting of lomustine (CCNU), cytarabine, and prednisone. Eight patients (42%) had complete remission and four (21%) had partial remission. The median survival time of the 19 patients was greater than 14 months. The eight patients who had complete remission were still alive as of May 1, 1982, with a median follow-up time of 632 days (range, 365-1247). We believe that this combination chemotherapy scheme warrants further investigation.
D000328:Adult; D000368:Aged; D003561:Cytarabine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008130:Lomustine / Q000008:administration & dosage* / Q000009:adverse effects; D008223:Lymphoma / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009607:Nitrosourea Compounds / Q000008:administration & dosage*; D011241:Prednisone / Q000008:administration & dosage*; D013921:Thrombocytopenia / Q000139:chemically induced
D009607:Nitrosourea Compounds; D003561:Cytarabine; D008130:Lomustine; D011241:Prednisone