[Role of Kupffer cells and hepatocytes in fibrinogen catabolism].
Products of fibrinogen degradation were studied after incubation of the protein with Kupffer's cells and hepatocytes, isolated from rabbit liver tissue, using immunochemical procedures and polyacrylamide gel electrophoresis in presence of sodium dodecylsulfate. The fibrinogenolysis was accompanied by a decrease in molecular mass of the protein and appearance of low molecular products of degradation, which were similar to those obtained after plasmin proteolysis of fibrinogen. An activator of plasminogen appears to be present in Kupffer's cells and hepatocytes; catabolism of fibrinogen may occur in liver tissue.
D000818:Animals; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism*; D007114:Immunization; D007120:Immunochemistry; D066298:In Vitro Techniques; D007728:Kupffer Cells / Q000276:immunology / Q000378:metabolism*; D008099:Liver / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D011817:Rabbits; D013917:Thrombin / Q000378:metabolism; D013997:Time Factors
D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen; D013917:Thrombin
Rol' kletok Kupfera i gepatotsitov v katabolizme fibrinogena.