3-thiomethylparacetamol sulphate and glucuronide: metabolites of paracetamol and N-hydroxyparacetamol.
1. Two new metabolites of paracetamol, 3-thiomethylparacetamol sulphate and glucuronide, have been isolated and identified. 2. The metabolites occurred in both rat and mouse urine after administration of either paracetamol of N-hydroxyparacetamol. The amount excreted increased proportionally with the dose.
D000082:Acetaminophen / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000652:urine; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains
D000082:Acetaminophen; C035718:3-thiomethylparacetamol; C017372:N-hydroxyacetaminophen; C035716:3-thiomethylparacetamol glucuronide