[Synthesis of influenza virus protein in the inhibition of cellular DNA transcription].
After preliminary UV-irradiation of cells as well as in the presence of actinomycin D the doses of both agents inhibiting influenza virus production are slightly lower than those inhibiting formation of viral proteins and considerably lower than those producing complete blocking of viral genome expression. These data demonstrate the existence of a cellular DNA-dependent factor the blocking of which prevents the formation of virus progeny without preventing primary transcription and formation of virion proteins. It is assumed that, apart from relatively small genes of cellular DNA participating in primary transcription of viral genome, some larger genes of the cell take part in some process of influenza virus reproduction.
D003609:Dactinomycin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005786:Gene Expression Regulation / Q000187:drug effects / Q000528:radiation effects; D009980:Influenza A virus / Q000235:genetics / Q000378:metabolism*; D012367:RNA, Viral / Q000096:biosynthesis / Q000528:radiation effects; D014158:Transcription, Genetic / Q000187:drug effects / Q000528:radiation effects*; D014466:Ultraviolet Rays; D014764:Viral Proteins / Q000096:biosynthesis* / Q000528:radiation effects; D014776:Virus Cultivation
D012367:RNA, Viral; D014764:Viral Proteins; D003609:Dactinomycin
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