[Effects of strict control of blood sugar by an artificial pancreas on nerve conduction velocity in diabetics].
This study concerned 13 patients with diabetes mellitus who, although under insulin therapy treatment, had poor control of their diabetes. Motor conduction velocity (MCV) in the peroneal, ulnar and median nerves, sensory conduction velocity (SVC) of the median nerve and sensory potential amplitude (SPA) of the median nerve were determined immediately before and after 24 h of strict control of blood glucose by an artificial pancreas. A significant increase in the MCV of the ulnar nerve (P less than 0.01) and in the SCV of the median nerve (P less than 0.05) was found. This acute improvement led us to presume that repair of anatomic lesions would be extremely unlikely. Only a metabolic disturbance due to hyperglycemia can be rapidly corrected. This metabolite alteration may be held partly responsible for the slowing of nerve conduction in diabetes. No significant difference was noted in the MCV of the peroneal nerve and of the median nerve and the SPA of the median nerve. This suggests that advanced degenerative lesions are present in these nerves particularly in the lower limbs. Such lesions cannot be rapidly reversed by metabolic control.
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007332:Insulin Infusion Systems; D008297:Male; D008475:Median Nerve / Q000503:physiopathology; D008875:Middle Aged; D009431:Neural Conduction; D010543:Peroneal Nerve / Q000503:physiopathology; D013127:Spinal Nerves / Q000503:physiopathology*; D014459:Ulnar Nerve / Q000503:physiopathology
D001786:Blood Glucose
Effets du contrôle strict de la glycémie pra pancréas artificiel sur les vitesses de conduction nerveuse chez le diabétique.