Progesterone in high doses may overcome progesterone's desensitization effect on lordosis by translocation of hypothalamic progestin receptors.
D000818:Animals; D002369:Castration; D002467:Cell Nucleus / Q000187:drug effects; D003600:Cytosol / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D007031:Hypothalamus / Q000187:drug effects*; D011374:Progesterone / Q000494:pharmacology*; D011980:Receptors, Progesterone / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D014178:Translocation, Genetic / Q000187:drug effects*
D011980:Receptors, Progesterone; D011374:Progesterone; D004958:Estradiol