[Changes, in the course of 24 hours, in the duration of the mitotic cycle S and G2 periods in mono- and binuclear hepatocytes of normal and thyroxinized rats].
The authors studied diurnal changes of ts and tG2 in the live of intact rats and of those given thyroxine during 6 days. Duration of S-phase changes from 8.0 to 9.8 h in mononuclear cells and from 7.0 to 9.1 h in binuclear cells of control animals. tG2 alters from 3.3 to 4.4 and from 3.0 to 4.6, respectively. Prolonged administration of thyroxine induced decrease of tG2 in both populations of hepatocytes. It has been established for both groups of cells that the length of S-phase is shortened or prolonged during 24 hours. The alterations in the thyroxine-treated animals are 7.0--11.4 and 5.4--9.6 hours in mono- and binuclear cells, respectively. The prolonged administration of the hormone induced more synchronous changes in S-phase during 24 hours in both populations of hepatocytes.
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects; D007399:Interphase / Q000187:drug effects; D008099:Liver / Q000166:cytology* / Q000187:drug effects; D008297:Male; D008938:Mitosis / Q000187:drug effects; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology*
C000717609:Tgm2 protein, rat; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D013974:Thyroxine
Izmeneniia v techenie sutok dlitel'nosti s i G2-periodov mitoticheskogo tsikla v odno- i dvuiadernykh gepatotsitakh u normal'nykh i tiroksinizirovannykh krys.