Prenatal and neonatal exposure to cimetidine results in gonadal and sexual dysfunction in adult males.
Exposure of rats to cimetidine during intrauterine life and the immediate neonatal period results in hypoandrogenization in adult life with decreased weights of androgen-dependent tissues and decreased concentrations of testosterone. Moreover, sexual behavior patterns in adult life are disturbed as shown by a lack of sexual motivation and decreased performance.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D000833:Animals, Suckling; D002927:Cimetidine / Q000378:metabolism / Q000633:toxicity*; D005260:Female; D006146:Guanidines / Q000633:toxicity*; D008297:Male; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects; D051381:Rats; D012733:Sex Differentiation / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects
D006146:Guanidines; D002927:Cimetidine