Effect of diethyl maleate on the biliary excretion rate of infused sulfobromophthalein-glutathione.
Diethyl maleate (DEM) was given intraperitoneally to rats in a dose (4.3 mmoles/kg) known to markedly decrease glutathione levels in liver. DEM induced a choleresis previously shown to be due to the osmotic activity of DEM conjugates (DEM-glutathione and subsequent metabolic products) excreted into bile. Coincident with the choleresis, the biliary excretory Tm for the infused glutathione conjugate of sulfobromophthalein (BSP-GSH) was depressed significantly. The data are interpreted as indicating that DEM-GSH conjugates compete with BSP-GSH conjugates for a canalicular carrier mechanism.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D004573:Electrolytes / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D008297:Male; D008298:Maleates / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013448:Sulfobromophthalein / Q000378:metabolism*; D013997:Time Factors
D004573:Electrolytes; D008298:Maleates; D013448:Sulfobromophthalein; C035816:(sulfobromophthalein)glutathione conjugate; C014476:diethyl maleate; D005978:Glutathione