Phagocyte chemotaxis in the perinatal period.
Cross-sectional and limited sequential studies of neutrophil and monocyte chemotaxis were done using cells isolated from cord blood and peripheral blood of 2- to 6-day-old neonates and infants at 4 and 6 months of age. These studies show that cord blood phagocyte chemotaxis is comparable to adult values, whereas phagocyte chemotaxis at 2-6 days of age is significantly lower than adult (P less than 0.01) or cord (P less 0.01) chemotaxis values. At 6 months of age, phagocyte chemotaxis is still low compared to adult values (P less than 0.01).
D000328:Adult; D000375:Aging; D002634:Chemotaxis, Leukocyte; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007958:Leukocyte Count; D009000:Monocytes; D009504:Neutrophils; D010586:Phagocytes