2-Acetylaminofluorene induces forms of cytochrome P-450 active in its own metabolism.
The effect of short-term treatment of rats with 2-acetylaminofluorene on the metabolism of this same compound by liver microsomes has been investigated. This treatment was found to increase the formation of 7-, 9-, and N-hydroxy-2-acetylaminofluorene 3-4 fold. The largest effect was seen in the formation of 5- and 3-hydroxy-2-acetylaminofluorene, which increased 105- and 27.3-fold, respectively. There was no significant increase in the formation of 1-hydroxy-2-acetylaminofluorene.
D015073:2-Acetylaminofluorene / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004790:Enzyme Induction; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
D003577:Cytochrome P-450 Enzyme System; D015073:2-Acetylaminofluorene