[Effect of S-carboxymethylcysteine on blood levels of amoxycillin and its diffusion through lung parenchyma and pleural exudate in the rat].
The fixed combination (10 : 3) of amoxycillin and S-carboxymethylcysteine, which is indicated in the therapy of the respiratory tract infections, was given to rats by oral route to determine the blood levels and the concentrations in the pulmonary parenchyma and pleural exudate. In comparison with the antibiotic alone the combination determined higher levels of amoxycillin in the blood (0.5, 1.2 hours after administration) in the homogenized lung tissue (2 hours after administration) and in pleural inflammatory exudate (0.5, 1, 2 hours after administration) caused by intrapleural injection of carrageenan. The enhanced distribution of the antibiotic in the target tissues further supports the clinical usefulness of this combination.
D000284:Administration, Oral; D000658:Amoxicillin / Q000008:administration & dosage / Q000097:blood*; D000818:Animals; D002233:Carbocysteine / Q000008:administration & dosage / Q000494:pharmacology*; D003545:Cysteine / Q000031:analogs & derivatives*; D004058:Diffusion; D004347:Drug Interactions; D008168:Lung / Q000378:metabolism*; D008297:Male; D010996:Pleural Effusion / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D002233:Carbocysteine; D000658:Amoxicillin; D003545:Cysteine
Influenza della S-carbossimetilcisteina sui livelli ematici di amoxicillina e sulla sua diffusibilità nel parenchyma polmonare ed essudato pleurico nel ratto.