[Manipulated selective inhibition of microcirculation in cancer tissues].
This paper confirms previous results that hyperglycemia (5 g/l) lasting 250 min, when combined with local hyperthermia (43 degrees C) for the last 100 min, strongly inhibits microcirculation in Yoshida sarcomas and DS-carcinosarcomas. This inhibition occurs independently of heparinization of the animals (700 IU/200 G body weight) so blood coagulation cannot be an important factor in the mechanism of microcirculation inhibition. After inhibition of microcirculation (detected by measuring tissue death after application of Evans' blue) the dye concentration in the tumor tissue increased unspecifically with a certain time delay and was then only slightly lower than in the untreated tumors. The causes of this observation area discussed. The blood volume of the tumors investigated amounted to about 4 vol.-%. The microcirculation of untreated tumors amounted to between 33 and 50% of the microcirculation of normal tissue (muscle). High doses of Evans' blue inhibited blood coagulation.
D000818:Animals; D002296:Carcinosarcoma / Q000098:blood supply*; D005070:Evans Blue; D005334:Fever / Q000503:physiopathology; D005947:Glucose / Q000494:pharmacology; D006943:Hyperglycemia / Q000139:chemically induced / Q000503:physiopathology; D008833:Microcirculation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012517:Sarcoma, Yoshida / Q000098:blood supply*
D005070:Evans Blue; D005947:Glucose
Die manipulierte selektive Hemmung der Mikrozirkulation im Krebsgewebe.