Activation of Trp-P-1 and Trp-P-2 in vitro and in vivo.
Isolated perfused livers were not able to activate the promutagens Trp-P-1 and Trp-P-2 to their genotoxic metabolites. On the contrary, inherently active mutagenic compounds were detected in the bile of living rats to which Trp-P-1 and Trp-P-2 had been administered intravenously. The excretion of active mutagens through the bile may explain the tumorigenic effect that these compounds exert on the liver during chronic feeding experiments.
D000201:Activation Analysis; D000818:Animals; D001646:Bile / Q000032:analysis / Q000378:metabolism*; D002243:Carbolines / Q000378:metabolism*; D066298:In Vitro Techniques; D007211:Indoles / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D009153:Mutagens / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D002243:Carbolines; D007211:Indoles; D009153:Mutagens; C019133:3-amino-1-methyl-5H-pyrido(4,3-b)indole; C019132:3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole