The sunburn cell in hairless mouse epidermis: quantitative studies with UV-A radiation and mono- and bifunctional psoralens.
The production of the sunburn cell by UV-A radiation and topical psoralens in hairless mouse epidermis has been studied. It has been shown that the appearance of this cell is dependent on the dose of both UV-A radiation and of the psoralen. The time-course with 8-methoxypsoralen has peak sunburn cell numbers at 28 hr postirradiation. A comparison of 2 bifunctional (8-methoxypsoralen and 5-methoxypsoralen) and 2 monofunctional (angelicin and 3-carbethoxypsoralen) psoralens showed the former are more potent. This suggests that DNA crosslink lesions may play a rle in sunburn cell production.
D000818:Animals; D004247:DNA / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D000078404:Epidermal Cells; D004817:Epidermis / Q000528:radiation effects*; D011564:Furocoumarins / Q000494:pharmacology*; D008297:Male; D008730:Methoxsalen / Q000494:pharmacology; D051379:Mice; D008812:Mice, Hairless; D012878:Skin Neoplasms / Q000209:etiology; D013471:Sunburn / Q000503:physiopathology; D013997:Time Factors; D014466:Ultraviolet Rays
D011564:Furocoumarins; D004247:DNA; D008730:Methoxsalen