Suppression of postganglionic sympathetic discharges by pentobarbital in endotoxic cats.
Pentobarbital (7-9 mg/kg) profoundly suppressed the sympathetic postganglionic cardiac and splenic discharges in endotoxic cats under chloralose anesthesia. Concurrently, the pre-existent tachycardia was replaced by bradycardia, and the blood pressure fell further. The findings are interpreted to imply a pentobarbital-induced sympatholysis.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D004525:Efferent Pathways / Q000187:drug effects*; D004731:Endotoxins / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000294:innervation; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D013154:Spleen / Q000294:innervation; D013564:Sympathetic Nervous System / Q000187:drug effects*
D004731:Endotoxins; D010424:Pentobarbital