Genetic polymorphism of coagulation factor XIIIB subunit in Japanese.
Genetic polymorphism of coagulation factor XIIIB subunit in Japanese has been described, using a thin-layer agarose gel isoelectric focusing followed by immunofixation. Phenotypes of factor XIIIB subunit were essentially classified into three common patterns A, B and AB. It is estimated that the phenotypes are determined by two codominant alleles. A new rare variant B' has been detected in Japanese. Gene frequencies calculated from 304 individuals showed FXIII-BA = 0.735, FXIII-BB = 0.252 and FXIII-BB' = 0.013, respectively. The distribution of phenotypes fitted the Hardy-Weinberg equilibrium.
D002648:Child; D005176:Factor XIII / Q000032:analysis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007525:Isoelectric Focusing; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic
D005176:Factor XIII