The effect of T-2 toxin on the bovine immune system: cellular factors.
The effect of T-2 toxin, a Fusarium metabolite, on the bovine cellular defense (immune) system was evaluated during high levels, chronic administration. The administration of T-2 toxin to calves at the rate of 0.6 mg/kg/day was associated with significant depression of lymphocyte responses to mitogens and significant decreases in chemotaxic migration of neutrophils.
D000818:Animals; D002417:Cattle; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000502:physiology; D009504:Neutrophils / Q000502:physiology; D012717:Sesquiterpenes / Q000494:pharmacology*; D013605:T-2 Toxin / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism
D012717:Sesquiterpenes; D013605:T-2 Toxin; D013936:Thymidine