Hepatic cirrhosis associated with long-term anticonvulsant drug therapy in dogs.
Advanced chronic hepatic disease was observed in 5 dogs that had received anticonvulsant drug therapy for 2 to 3 years. Clinical signs included anorexia, weakness, and restlessness, and 2 dogs also had ascites. There were remarkable increases in the serum activities of alanine aminotransferase, alkaline phosphatase, and gamma-glutamyl transferase. The total serum bile acid concentration was high in 3 of 4 dogs that were tested. Sulfobromophthalein excretion was delayed in all dogs. Histologic examination of liver specimens from 4 of the dogs demonstrated macronodular or micronodular cirrhosis.
D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects*; D004283:Dog Diseases / Q000139:chemically induced* / Q000473:pathology; D004285:Dogs; D005260:Female; D008099:Liver / Q000648:ultrastructure; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D008297:Male; D008854:Microscopy, Electron; D010634:Phenobarbital / Q000009:adverse effects; D010672:Phenytoin / Q000009:adverse effects; D011324:Primidone / Q000009:adverse effects
D000927:Anticonvulsants; D011324:Primidone; D010672:Phenytoin; D010634:Phenobarbital