Biochemical and hematologic correlates of alcoholism and liver disease.
Quadratic multiple discriminant analysis of 25 commonly ordered laboratory tests resulted in correct classification of 100% of nonalcoholics without overt liver disease, 98% of alcoholism treatment program patients with presumed mild liver involvement, 96% of alcoholics with liver disease, and 89% of nonalcoholics with liver disease. Direct comparison of the biopsy-verified alcoholic and nonalcoholic liver disease groups resulted in 100% discrimination, and removal of traditionally evaluated liver tests from the battery of 25 tests did not substantially alter the original classification accuracy. Alcoholic and nonalcoholic liver disease was still 100% differentiable when equated for number of patients with cirrhosis, hepatitis, and hepatitis combined with cirrhosis or fibrosis. Additional utility of the quadratic discriminant approach was demonstrated when 83% alcoholic and 83% nonalcoholic liver disease cases were diagnosed correctly in a prospective manner. In contrast, use of aspartate aminotransferase to alanine aminotransferase ratios (ie, SGOT to SGPT) identified correctly 75% and 33% of patients, respectively.
D000428:Alcohol Drinking; D000437:Alcoholism / Q000097:blood / Q000175:diagnosis* / Q000628:therapy; D004796:Clinical Enzyme Tests; D003937:Diagnosis, Differential; D004909:Erythrocyte Indices; D006400:Hematocrit; D006801:Humans; D008099:Liver / Q000503:physiopathology; D008107:Liver Diseases / Q000097:blood / Q000175:diagnosis*; D008108:Liver Diseases, Alcoholic / Q000097:blood / Q000175:diagnosis*; D008111:Liver Function Tests; D008297:Male; D000637:Transaminases / Q000097:blood
D000637:Transaminases