G gamma and a gamma globin chain synthesis in bone marrow and peripheral blood of beta-thalassaemia homozygotes.
G gamma, A gamma and beta globin chain synthesis has been investigated in the peripheral blood and bone marrow from eight beta-thalassaemia homozygotes. In five out of eight cases total gamma chain synthesis was higher in the peripheral blood than in the bone marrow; in seven out of eight cases A gamma chain synthesis was markedly higher in the marrow than in the peripheral blood. These data suggest that ineffective erythropoiesis selects F-cells synthesizing the largest amounts of G gamma chains, while A gamma producing cells are preferentially destroyed in the marrow.
D000293:Adolescent; D000328:Adult; D000409:Alanine / Q000378:metabolism; D001773:Blood Cells / Q000378:metabolism; D001853:Bone Marrow / Q000378:metabolism*; D002478:Cells, Cultured; D005260:Female; D005914:Globins / Q000096:biosynthesis*; D005998:Glycine / Q000378:metabolism; D006720:Homozygote; D006801:Humans; D007525:Isoelectric Focusing; D008297:Male; D013789:Thalassemia / Q000378:metabolism*
D005914:Globins; D000409:Alanine; D005998:Glycine