Double-blind crossover study of nabumetone versus naproxen in the treatment of osteoarthritis of the knee and hip.
Twenty-five patients suffering from osteoarthritis (O.A.) of the hip or knee were treated with nabumetone (1 g at night) or naproxen (250 mg b.i.d.) during 4 weeks starting either with nabumetone (twelve patients) or with naproxen (thirteen patients). The results of the study were subjected to a statistical analysis which showed good efficacy for both drugs. Tolerance was better with nabumetone than with naproxen. Nabumetone (1 g at night) appeared, thus, to be a good and very well tolerated anti-inflammatory drug in the treatment of osteoarthritis.
D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002074:Butanones / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004361:Drug Tolerance; D006621:Hip Joint / Q000187:drug effects; D006801:Humans; D007719:Knee Joint / Q000187:drug effects; D008124:Locomotion / Q000187:drug effects; D000077430:Nabumetone; D009288:Naproxen / Q000009:adverse effects / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D002074:Butanones; D009288:Naproxen; D000077430:Nabumetone