[Isolation and identification of the antibiotics amicetin and nebramycin formed by a Streptomyces coeruleoaurantiacus 4009 culture].
It was found that Str. coeruleoaurantiacus, strain 4009 produced antibiotics 4009-A and 4009-B belonging to different groups. Antibiotic 4009-A was identified as amicetin belonging to the group of pyrimidine bases and antibiotic 4009-B as the nebramycin complex belonging to the group of aminoglycosides. The identity of the antibiotics was confirmed by the physico-chemical constants, spectral and chromatographic characteristics and their chemotherapeutic activity.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D001424:Bacterial Infections / Q000188:drug therapy; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004353:Drug Evaluation, Preclinical; D051379:Mice; D008970:Molecular Weight; D009328:Nebramycin / Q000032:analysis / Q000302:isolation & purification* / Q000627:therapeutic use; D011741:Pyrimidine Nucleosides / Q000032:analysis / Q000302:isolation & purification* / Q000627:therapeutic use; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D011741:Pyrimidine Nucleosides; C004413:amicetin; D009328:Nebramycin
Vydelenie i identifikatsiia antibiotikov amitsetina i nebramitsina, obrazuemykh kul'turoĭ Streptomyces coeruleoaurantiacus 4009.