[In vitro effect of culture fluids from neoplastic tissues on platelet aggregation. II. Experimental tumors].
We have investigated the effects on platelet function of culture media from 2 sublines of a benzopyrene-induced murine sarcoma (mFS6). Platelet aggregation was investigated according to Born's method. The cell line with greater "in vivo" invasiveness showed higher aggregating activity and higher increase on ADP-induced aggregation; these effects were inhibited by the preincubation of platelets with Aspirin (0,1 mM). These results suggest the role of platelets in metastasis formation; the possibility to inhibit pharmacologically the interactions between platelets and tumour cells could have important implications from both speculative and practical viewpoints.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D003470:Culture Media / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D010974:Platelet Aggregation / Q000187:drug effects*; D012513:Sarcoma, Experimental / Q000032:analysis*
D003470:Culture Media; D000244:Adenosine Diphosphate; D001241:Aspirin
Azione in vitro sull'aggregazione piastrinica dei liquidi di coltura di tessuti neoplastici. II) Tumori sperimentali.