Hemoglobin Parchman: double crossover within a single human gene.
Structural analysis of a new variant hemoglobin revealed tryptic peptides with the amino acid composition of normal delta-globin, except for two internal peptides, which had the compositions of normal beta-globin. The most likely explanation for these findings is that a double, nonhomologous crossover between the delta-and beta-globin genes had occurred.
D000595:Amino Acid Sequence; D003434:Crossing Over, Genetic; D005914:Globins / Q000235:genetics; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans
D006455:Hemoglobins, Abnormal; D005914:Globins