Raised endogenous monoamine oxidase inhibitor output in postwithdrawal alcoholics: effects of L-dopa and ethanol.
Urinary output of endogenous monoamine oxidase inhibitor was significantly greater in a group of postwithdrawal alcoholics than in controls. An oral dose of 0.5 g of L-dopa reduced output to control values in the alcoholics, but in the controls themselves output was unaffected. A similar excretion pattern to unextracted samples was observed in ethyl acetate extracts of these urine samples, acidified to pH 1. In a second group of postwithdrawal alcoholics, where the L-dopa effect was confirmed, ethanol administration brought about a small but not significant reduction in inhibitor output.
D000328:Adult; D000437:Alcoholism / Q000652:urine*; D001007:Anxiety / Q000187:drug effects; D003404:Creatinine / Q000652:urine; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000652:urine*
D008996:Monoamine Oxidase Inhibitors; D000431:Ethanol; D007980:Levodopa; D003404:Creatinine