Pimozide-induced chronic hyperprolactinaemia and quantitative initiation of spermatogenesis in maturing rats.
When pimozide was given to maturing rats, a rise in the level of prolactin in the serum was accompanied by a fall in LH. There was also incomplete initiation of spermatogenesis as well as simultaneous adrenal hypertrophy. Bilateral adrenalectomy failed to prevent hyperprolactinaemia-induced antispermatogenic response, while a significant ameliorating effect was observed with LH, indicating that hyperprolactinaemia influenced the quantitative initiation of spermatogenesis by affecting the secretion of LH.
D000311:Adrenal Glands / Q000187:drug effects; D000315:Adrenalectomy; D000818:Animals; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010868:Pimozide / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D012741:Sexual Maturation / Q000187:drug effects*; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects
D010868:Pimozide; D011388:Prolactin; D007986:Luteinizing Hormone