Treatment of cutaneous malignant melanoma in Israel, 1960 to 1970.
A retrospective study was performed of 512 patients suffering from primary cutaneous malignant melanoma of the skin who had been treated in Israel between 1960 and 1970. The patients were randomly admitted to six hospitals and treated according to different protocols, based on the policy of each hospital. Our conclusions are that in stage I of the disease, radical prophylactic lymph-node dissection (RPLND) improved the prognosis in all three levels of tumor invasion into the skin; in stage II of the disease, RPLND did not improve the prognosis when compared to wide excision of the tumor and excision of the clinically involved nodes; and in stage I of the disease, there is no statistically significant difference in prognosis between excisional biopsy and wide excision of the tumor.
D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D012878:Skin Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*