Creatinine X--potential nonrenal elimination of endogenous creatinine in humans and its clinical significance.
From an analysis of the data in the literature for creatinine renal clearance and steady-state serum level and published equations, we estimated a wide range (1.4-76.3 ml/min) of nonrenal clearances of endogenous creatinine. Nonrenal clearance might contribute 0-34% of the total body clearance in patients with normal renal function. This paper discusses the clinical significance of the potential overestimation of renal function by using published nomograms or equations (derived from a direct inverse relationship between the creatinine clearance and steady-state level or the assumption of nonexistence of nonrenal elimination of creatinine) for indirect estimation of creatinine clearances from serum creatinine levels.
D003404:Creatinine / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000378:metabolism
D003404:Creatinine