[Effect of prolonged beta-adrenergic blockade on myocardial energy metabolism in coronary occlusion].
It has been shown that a single intravenous injection of obsidan (0.1 mg/kg) to dogs during acute coronary occlusion results in a decrease in the activities of "a" phosphorylase, Mg-dependent ATPase, creatine phosphokinase, succinate dehydrogenase and cytochrome-c-oxidase, in a slight lowering of the ATP content accompanied by the increased content of AMP and unchanged concentration of creatine phosphate. Repeated injections of the drug in the same dose raise the activities of the enzymes up to the control level and produce activation of glycogenolysis and succinate dehydrogenase during the reparative period. The drug favours the preservation of "b" phosphorylase activity in the infarcted tissue and does not change the content of adenine nucleotides and creatine phosphate upon prolonged application.
D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy / Q000378:metabolism*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011433:Propranolol / Q000627:therapeutic use*; D013997:Time Factors
D011433:Propranolol
Vliianie dlitel'noĭ beta-adrenoblokady na énergeticheskiĭ metabolizm miokarda pri koronarookkliuzii.