Dispermic origin and clinical outcome of three complete hydatidiform moles with 46,XY karyotype.
Three new cases of complete, classic hydatidiform mole with a 46,XY karyotype are described. They originated by dispermy as demonstrated by chromosome and enzyme analyses. Levels of human chorionic gonadotropin decreased to normal spontaneously within a short time, indicating a benign course in these three cases. Of a total of 18 cases reported to data, postoperative clinical information was available for 10 patients. Two of these 10 patients had a malignant course with lung metastases. It is of theoretical and clinical importance to establish the magnitude of the risk of malignancy for hydatidiform mole with a 46,XY karyotype.
D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics* / Q000378:metabolism; D007621:Karyotyping; D008175:Lung Neoplasms / Q000556:secondary; D011247:Pregnancy; D012306:Risk; D014594:Uterine Neoplasms / Q000235:genetics* / Q000378:metabolism
D006063:Chorionic Gonadotropin