Development of a method for study of the tendency of drug products to adhere to the esophagus.
A method to determine the adherence of drugs to the esophagus was developed using isolated swine esophagi. A number of types of tablets and capsules (e.g., of doxycycline) were tested. The results showed that the tendency of products to adhere to the esophagus can be regulated by pharmaceutical properties. It was concluded that the method described is simple, inexpensive, and accurate.
D000268:Adhesiveness; D000818:Animals; D002214:Capsules; D004318:Doxycycline / Q000008:administration & dosage; D004947:Esophagus / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D013499:Surface Properties; D013552:Swine; D013607:Tablets; D013997:Time Factors
D002214:Capsules; D004364:Pharmaceutical Preparations; D013607:Tablets; D004318:Doxycycline