Toxicity study of oxfendazole in pregnant sows.
The safety of oxfendazole when administered to pregnant sows was assessed. Thirty-six pregnant sows were dosed orally on repeated occasions at dose rates of 4.5 mg/kg bodyweight and 13.5 mg/kg during the critical period of embryo organogenesis and implantation. Twelve sows were observed as untreated controls. Oxfendazole was administered as 6.48 per cent medicated pellets. Records were kept of the reproductive performance of all 48 sows. There were no obviously drug-related clinical signs of toxicity in the sows after treatment with oxfendazole, neither were drug-related anatomical or behavioural abnormalities detected in the newborn pigs.
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology / Q000662:veterinary; D000818:Animals; D000871:Anthelmintics / Q000633:toxicity*; D001562:Benzimidazoles / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects*; D013552:Swine / Q000502:physiology*; D013553:Swine Diseases / Q000453:epidemiology
D000871:Anthelmintics; D001562:Benzimidazoles; C011030:oxfendazole