Central effect of ergometrine on gastric acid secretion in rats.
1. The ergot alkaloid ergometrine administered by rapid intravenous injection (0.5--4 mg/kg) or by continuous intravenous infusion (0.5--2 mg/kg per hr) stimulated gastric acid secretion in rats and its effect was antagonized by cimetidine (2 mg/kg per hr). 2. The gastric stimulant action can be elicited also by intracerebro-ventricular administration (25--100 micrograms) suggesting a central mechanism of action of ergometrine.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D004874:Ergonovine / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D051381:Rats
D006632:Histamine; D004874:Ergonovine