Possible modulatory role of dynorphin on the excitation by neurotensin on the guinea pig myenteric plexus.
Dynorphin 1-13 antagonized in a concentration-dependent fashion the contractile effect of neurotensin on the isolated preparation of the guinea pig ileum myenteric plexus. The inhibitory action of dynorphin was reduced in the presence of naloxone indicating the opioid nature of this interaction. Atropine also reduced the excitatory component of the neurotensin-induced contractile response; the joint application of atropine plus dynorphin did not cause additional inhibition of the contractile effect of neurotensin.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004399:Dynorphins; D004723:Endorphins / Q000494:pharmacology*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009197:Myenteric Plexus / Q000187:drug effects / Q000502:physiology*; D009270:Naloxone / Q000494:pharmacology; D009294:Narcotics / Q000494:pharmacology*; D009496:Neurotensin / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*
D004723:Endorphins; D009294:Narcotics; D010446:Peptide Fragments; D009270:Naloxone; D009496:Neurotensin; C026843:dynorphin (1-13); D004399:Dynorphins; D001285:Atropine