Genetics of complement C4. Two homoduplication haplotypes C4S C4S and C4F C4F in a family.
A family in which two homoduplicated C4 haplotypes (or supergenes) segregate is described. One haplotype C4F*3 C4F*2.2 is composed of two C4F alleles and the other C4S*5.1 C4S*1 of two C4S alleles. The C4F duplication haplotype is a partial inhibitor of the Rodgers antigen, and judged from our family and population material, it seems to be rather frequent and associated with HLAB*35, Bf*F, and HLAD/DR*1. The C4S duplication haplotype is Rg(a-) and is not identified in individuals without another S, Ch(A+) variant.
D000328:Adult; D002648:Child; D003181:Complement C4 / Q000235:genetics*; D004586:Electrophoresis; D005260:Female; D005796:Genes; D006801:Humans; D008297:Male; D010375:Pedigree; D010641:Phenotype
D003181:Complement C4