Acute oral toxicity of 4-dimethylaminophenol to the gastrointestinal tract, liver and kidney of the rat.
Single oral doses up to 25 mg/kg body weight of methaemoglobin-inducing cyanide antidote, 4-dimethylaminophenol (DMAP) did not result in any gross or histological abnormality in the gastrointestinal tract, liver and kidneys of rats killed up to 24 h after the dose. In animals kept for 7 days after the dose to abnormality was observed in the organs examined or in blood samples taken during the course of the experiment.
D000627:Aminophenols / Q000633:toxicity*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced*; D006366:Heinz Bodies / Q000187:drug effects; D007674:Kidney Diseases / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000627:Aminophenols; C020292:4-dimethylaminophenol