Peritoneal transport of vancomycin in 4 patients undergoing continuous ambulatory peritoneal dialysis.
The pharmacokinetics of vancomycin have been studied in 4 chronic renal failure patients undergoing continuous ambulatory peritoneal dialysis. Patients received 1 g of vancomycin in 2 liters of dialysate during an initial phase, and serum and dialysate samples were collected for vancomycin determination. 54% of the amount introduced into the peritoneal cavity were absorbed systemically during a 6-hour cycle. Peak serum concentrations averaged 23.7 microgram/ml. Mean elimination half-life was calculated to be 66.9 h, and dialysis clearance averaged 2.4 ml/min.
D000328:Adult; D001202:Ascitic Fluid / Q000032:analysis; D005260:Female; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010537:Peritoneum / Q000378:metabolism; D014640:Vancomycin / Q000032:analysis / Q000097:blood / Q000378:metabolism*
D014640:Vancomycin