The study of X-rays and TCDD effects on satellite associations may suggest a simple model for application in environmental mutagenesis.
Satellite associations were used as parameters to test nucleolar organizer activity. Assuming that toxic and/or mutagenic agents may affect the ribosomal genes, satellite associations in human lymphocytes were analysed following exposure to X-rays and compared with the satellite association pattern of subjects exposed to TCDD. A significant decrease in the satellite association frequency in D group chromosomes was found both in irradiated lymphocytes and in subjects exposed to Dioxin. The findings seem to be in accordance with the hypothesis based on random damage of functional nucleolar organizing regions.
D002478:Cells, Cultured; D002877:Chromosomes, Human / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure; D004276:DNA, Satellite / Q000528:radiation effects*; D004147:Dioxins / Q000494:pharmacology*; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000648:ultrastructure; D009697:Nucleolus Organizer Region / Q000187:drug effects / Q000528:radiation effects*; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology*; D014965:X-Rays
D004276:DNA, Satellite; D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins