Mechanism of protection against carbon tetrachloride toxicity. I. Prevention of lethal effects by partial surgical hepatectomy.
Both partial surgical hepatectomy and a challenge with a small dose of CCl4 depress the metabolism of xenobiotics in the liver. In fact, hepatocytes become provided with metabolic activity rates which are peculiar of either embryo or newborn rat liver. These experiments have shown that partial surgical hepatectomy prevents rats from death caused by otherwise lethal doses of CCl4. At the same time, sham-operated animals survive to a limited extent after a large dose of the halogen compound. Investigations carried out on the metabolic efficiency of liver microsomes, both in vito and in vivo, clearly demonstrate that the preventive effect against CCl4 depends mainly on the impaired metabolic activity of endoplasmic reticulum.
D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D002251:Carbon Tetrachloride / Q000378:metabolism; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control*; D006498:Hepatectomy; D006591:Hexobarbital / Q000633:toxicity; D050356:Lipid Metabolism; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects; D013056:Spectrophotometry, Ultraviolet
D006591:Hexobarbital; D002251:Carbon Tetrachloride; D000633:Aminopyrine N-Demethylase