Intravesical single and combination therapy in superficial bladder cancer. An experimental study.
In this animal experiment it was investigated if intravesical combination therapy is superior to single drug therapy to reduce the growth of N-butyl-N(4-hydroxybutyl)-nitrosamine (BBN)-induced bladder carcinomas in the rat. The evaluation of the histological data gave the following results: intravesical instillation of cytostatic drugs in concentrations similar to that used in man reduce the growth of BBN-induced tumors. The effectiveness of mitomycin C or adriamycin alone is similar to that of alternative administration of mitomycin C and adriamycin.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002085:Butylhydroxybutylnitrosamine; D004317:Doxorubicin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D008937:Mitomycins / Q000008:administration & dosage; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D001743:Urinary Bladder / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology
D000970:Antineoplastic Agents; D008937:Mitomycins; D002085:Butylhydroxybutylnitrosamine; D004317:Doxorubicin