Does hypothermia play a relevant role in the glycemic alterations induced by ethanol?
The potential of ethanol-induced hypothermia on the glycemic alterations induced by this drug were evaluated. In Experiment 1 ambient temperature was manipulated. After 4.0 g/kg of ethanol blood glucose levels and body temperature were assessed in fed or 48 hr starved rats at either 21 degrees C or 28 degrees C room temperature. Hyper or hypoglycemia was observed depending on both the feeding condition and the environmental temperature. In Experiment 2, this hypothesis was tested by determining if rats tolerant to the thermic effects of ethanol would show a decreased glycemic response. The results support this assumption.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001833:Body Temperature Regulation / Q000187:drug effects*; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D000431:Ethanol