Acquired Gaucher's cells in Hodgkin's disease.
A patient with Hodgkin's disease associated with low glucocerebrosidase levels in the peripheral leukocytes, and Gaucher's cells in the bone marrow and lymph nodes, is described. After MOPP therapy, complete remission of Hodgkin's disease was accompanied by normalization of the glucocerebrosidase level and disappearance of Gaucher's cells. This observation appears unique when compared with the four cases of combined Hodgkin's and Gaucher's disease reported in earlier literature in which Gaucher's disease remained unchanged after chemotherapy. We conclude that our patient had Hodgkin's disease and acquired Gaucher's cells with diminished glucocerebrosidase levels, rather than a combination of Hodgkin's disease and Gaucher's disease.
D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D005776:Gaucher Disease / Q000150:complications / Q000473:pathology*; D005959:Glucosidases / Q000378:metabolism*; D005962:Glucosylceramidase / Q000378:metabolism*; D006689:Hodgkin Disease / Q000150:complications / Q000201:enzymology / Q000473:pathology*; D006801:Humans; D007962:Leukocytes / Q000201:enzymology; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008875:Middle Aged
D005959:Glucosidases; D005962:Glucosylceramidase