The effects of nifedipine and verapamil on spontaneous and carbachol-stimulated contractions of rat urinary bladder "in vivo".
The effects of nifedipine and verapamil on spontaneous and carbachol-induced contractions of rat urinary bladder have been studied after intravenous administration. Both nifedipine and verapamil delayed the onset of spontaneous contractions in a dose-dependent manner, but nifedipine on the contrary of verapamil only slightly antagonized the intensity of spontaneous contractions and of carbachol contracture. These results suggest that the effects of verapamil on rat urinary bladder "in vivo" are different from those of nifedipine.
D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009543:Nifedipine / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D001743:Urinary Bladder / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology*
D011725:Pyridines; D002217:Carbachol; D014700:Verapamil; D009543:Nifedipine