[PDGF (platelet derived growth factor): a regulator of connective tissue proliferation or an artefact?].
Platelets carry, and release after stimulation, mitotic activities for connective tissue cells in culture. One of these activities has been studied carefully: the PDGF, it is a peptide, molecular weight 30,000, pHi 9.8-10, heat stable. Beside this mitotic activity, PDGF bears migrative, chemotactic and metabolic functions. Hypothetical theories have implicated PDGF in different pathological conditions (atherosclerosis, myelofibrosis, ...) but there is no direct proof that PDGF is active in vivo. Recently there has been experimental data suggesting that the mitotic activity of PDGF in vitro could be a technical artefact.
D001792:Blood Platelets / Q000378:metabolism*; D002478:Cells, Cultured; D002633:Chemotaxis; D003239:Connective Tissue Cells; D006133:Growth Substances / Q000097:blood* / Q000302:isolation & purification / Q000502:physiology; D006801:Humans; D008938:Mitosis; D008970:Molecular Weight; D010455:Peptides / Q000097:blood* / Q000302:isolation & purification / Q000502:physiology; D010982:Platelet-Derived Growth Factor
D006133:Growth Substances; D010455:Peptides; D010982:Platelet-Derived Growth Factor
Le PDGF (facteur mitogénique d'origine plaquettaire): un régulateur de prolifération des tissus conjonctifs ou un artéfact?