Measurement of radioactive tracer microsphere blood flow with NaI (T1)-and Ge-well type detectors.
An intrinsic Ge-well type detector was applied for the detection of gamma rays from labeled tracer microspheres. The high energy resolution and the large peak-to-Compton ratio of this spectrometer ensures the application of all available differently labeled tracer microspheres in one experiment. The superior energy resolution of the Ge-detector was documented with the separated photopeak regions of 103-Ru and 85-Sr-labeled tracer microspheres, which result in a single photopeak when an NaI(T1) detector is used. The Ge-well type detector was compared with an NaI(T1) spectrometer by counting samples of cardiac muscle in either spectrometer systems. Regression analysis between both spectrometer systems demonstrate identical flow values in these samples for 5 differently labeled tracer microspheres which were administered in 5 dogs. The high sensitivity of the Ge-well-type detector together with a suitable technique for sampling of myocardial tissue accomplishes a high spatial resolution of myocardial perfusion for all available differently labeled tracer microspheres.
D000818:Animals; D001783:Blood Flow Velocity; D003326:Coronary Circulation; D003327:Coronary Disease / Q000503:physiopathology; D004285:Dogs; D006321:Heart / Q000503:physiopathology; D008863:Microspheres; D011849:Radioactive Tracers; D011868:Radioisotopes; D013051:Spectrometry, Gamma / Q000295:instrumentation*
D011849:Radioactive Tracers; D011868:Radioisotopes