Behavioral and electrophysiological analyses of the effects of 2-o-chlorobenzoyl-4-chloro-n-methyl-n alpha-glycylglycinanilide hydrate (45-0088-S) in the CNS in cats and monkeys.
Behavioral and electrophysiological comparative analyses of the effects of 2-o-chlorobenzoyl-4-chloro-N-methyl-N alpha-glycylglycinanilide hydrate (45-0088-S) and diazepam on the CNS were performed with cats and monkeys. No essential difference between 45-0088-S and diazepam on the effects in the CNS was observed, although the "taming" effect in wild cats and the hypnotic effect in monkeys caused by 45-0088-S were stronger than those of diazepam. The sleep-wakefulness cycles in both cats and monkeys were modified by 45-0088-S. The activity of the reticular formation, hypothalamus and amygdala in cats was inhibited by 45-0088-S and by diazepam.
D000679:Amygdala / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000502:physiology; D002415:Cats; D002490:Central Nervous System / Q000502:physiology*; D003975:Diazepam / Q000494:pharmacology; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004569:Electroencephalography; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007031:Hypothalamus / Q000502:physiology; D008253:Macaca mulatta / Q000502:physiology; D008297:Male; D012890:Sleep / Q000187:drug effects
C026735:2-(2-chlorobenzoyl)-4-chloro-N-methyl-N'-glycylglycinanilide; D003975:Diazepam; D005998:Glycine