Apomorphine and glycoprotein synthesis during consolidation.
The dopamine agonist, apomorphine, was injected intrahippocampally immediately after acquisition of a brightness discrimination task, which was motivated by footshock in rats. This led to an increase in the incorporation of L-fucose into total proteins which were measured in the hippocampus 7-9 hours later. In behavioral experiments, the same application improved the retention of a learned task. A possible linkage between increased glycoprotein synthesis and improvement of the retention of a new learned behavior due to the action of apomorphine is discussed.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D004193:Discrimination Learning / Q000502:physiology; D005643:Fucose / Q000378:metabolism; D006023:Glycoproteins / Q000096:biosynthesis*; D006624:Hippocampus / Q000378:metabolism*; D007858:Learning / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D006023:Glycoproteins; D009419:Nerve Tissue Proteins; D005643:Fucose; D001058:Apomorphine; D001205:Ascorbic Acid