Effects of N-demethylated carbachol on intraocular pressure and pupil in ocular hypertensive patients.
The effects of N-demethylated carbachol on intraocular pressure and pupil size were studied in 18 ocular hypertensive patients. Topical administration of N-demethylated carbachol in 9%, 15% and 30% solutions has been demonstrated to bring about miosis which was found to be dose-dependent. No significant change of intraocular pressure clearly attributable to this drug has been demonstrated.
D000287:Administration, Topical; D002217:Carbachol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008916:Miotics / Q000494:pharmacology; D009798:Ocular Hypertension / Q000188:drug therapy*; D010277:Parasympathomimetics / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects*
D008916:Miotics; D010277:Parasympathomimetics; D002217:Carbachol; C016348:N-demethylcarbachol