[Glutaraldehyde - fixed human umbilical cord vein as a small diameter arterial substitute. Experimentation on the monkey].
Autologous saphenous veins, the preferred substitute material for aorto-coronary, femoro-popliteal and femoro-tibial by-pass, are usable in only 70% of individuals in need of such procedures. The development of small diameter substitute arteries is therefore essential to broaden the pool of patients who could benefit from this class of cardiovascular surgery. Existing substitutes, however, present major difficulties and have had limited success. In this laboratory, an attempt has been made to develop a vessel of 3 millimetres or less in diameter derived from human umbilical cord processed in glutaraldehyde. This substitute can be stored in 45% ethanol or dessicated by critical point drying. This device had been implanted as a segment of abdominal aorta in eight primates (Macaca fascicularis). Preliminary results are disappointing. The indicate that retention of a patency for more than a year post-implantation is difficultly achievable and that connective tissue hyperplasia leading to occlusion at the anastomoses is a major problem. Similar but larger diameter by-passes in the order of 6-8 millimetres should be investigated in greater detail, in order to better establish the "in-vivo" behavior of this class of tissue prosthesis. This would address the more fundamental issues pertaining to the clinical usefulness of fixed biological tissue by-pass devices.
D000818:Animals; D001158:Arteries / Q000601:surgery*; D001705:Bioprosthesis; D005260:Female; D006801:Humans; D008252:Macaca fascicularis; D008297:Male; D008875:Middle Aged; D014471:Umbilical Veins / Q000637:transplantation*
La veine ombilicale humaine traitée au glutaraldéhyde comme substitut artériel de petit diamètre. Expërimentation sur le singe.