[Levels of xenobiotic metabolizing enzyme activities of xenobiotic tissue in different animal species].
Aminopyrine-N-demethylase, p-nitroanisole-O-demethylase and lipid peroxidation were determined in liver postmitochondrial fractions (S-9) of mice in the basal state and after induction with beta-naphtoflavone, sodium phenobarbital, or both the inducers. The two activities were similar in their response to all inductions: meanly, 1,2 times with beta-NF, 2,0 times with Na-PB, 5,8 times with Na-PB+ beta-NF. Lipid peroxidation was sensibly more active in basal animals with respect to that with induction. The results are discussed in a partial review of the sector literature, which deserves still much work to be completed.
D000633:Aminopyrine N-Demethylase / Q000032:analysis*; D000818:Animals; D001571:Benzoflavones / Q000494:pharmacology; D005260:Female; D008054:Lipid Peroxides / Q000032:analysis; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D009575:Nitroanisole O-Demethylase / Q000032:analysis*; D010088:Oxidoreductases / Q000032:analysis*; D010634:Phenobarbital / Q000494:pharmacology; D013045:Species Specificity; D019324:beta-Naphthoflavone
D001571:Benzoflavones; D008054:Lipid Peroxides; D019324:beta-Naphthoflavone; D009575:Nitroanisole O-Demethylase; D010088:Oxidoreductases; D000633:Aminopyrine N-Demethylase; D010634:Phenobarbital
Livelli di attività enzimatiche metabolizzanti gli xenobiotici in differenti specie animali.