Bilirubin-induced modulation of cerebral protein phosphorylation in neonate rabbits in vivo.
Protein phosphorylation in cerebral cell-free preparations from neonate rabbits was inhibited by bilirubin and promoted by aminophylline when these substances had been administered intravenously. In animals given both compounds, the bilirubin-induced inhibition of phosphorylation was partly reversed by aminophylline. Adenosine 3',5'-monophosphate added in vitro during the assays also increased protein phosphorylation. These data introduce new concepts in the pathogenesis of kernicterus.
D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D001663:Bilirubin / Q000378:metabolism / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D011817:Rabbits
D009419:Nerve Tissue Proteins; D000628:Aminophylline; D011494:Protein Kinases; D001663:Bilirubin