Ruptured intracranial aneurysms: has the incidence of early rebleeding been over-estimated?
Of 110 consecutive patients with ruptured intracranial aneurysms, 49 underwent delayed neurological deterioration, involving 57 episodes in all. During the first three weeks after the presenting haemorrhage less than a third of these episodes were due to confirmed rebleeding. Rebleeding episodes were found to have a "flat" distribution in time during this period, but episodes of non-haemorrhagic deterioration "peaked" between days 4-12. This peak coincides with the peak for rebleeding which was described in earlier studies on aneurysms, and it is suggested that confusion between non-haemorrhagic deterioration and rebleeding may have led to a significant over-estimate of the incidence of early rebleeding with important implications for the optimum timing of surgical intervention.
D002533:Cerebral Angiography; D006801:Humans; D002532:Intracranial Aneurysm / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery; D002546:Ischemic Attack, Transient / Q000175:diagnosis; D008875:Middle Aged; D012008:Recurrence; D012422:Rupture, Spontaneous; D013345:Subarachnoid Hemorrhage / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014148:Tranexamic Acid / Q000627:therapeutic use
D014148:Tranexamic Acid