Multisystem presentation of eosinophilic fasciitis.
A 20-year-old man experienced the onset of progressive scleroderma-like skin changes with eosinophilia and hypergammaglobulinaemia after strenuous military activity. A biopsy showed faciitis. Concomitant splenomegaly, polysynovitis, restrictive lung function, myositis, decrease hepatic clotting factors and proteinuria were documented. He responded well to corticosteroids, relapse upon their discontinuation and had a complete remission of both skin and systemic features while on penicillamine and azathioprine. He is new in good health and has received no medication for the past two years.
D000328:Adult; D000843:Ankle Joint / Q000473:pathology; D001379:Azathioprine / Q000627:therapeutic use; D001799:Blood Sedimentation; D001856:Bone Marrow Examination; D004551:Elbow Joint / Q000473:pathology; D004802:Eosinophilia / Q000150:complications / Q000276:immunology / Q000473:pathology*; D005208:Fasciitis / Q000150:complications / Q000276:immunology / Q000473:pathology*; D005384:Finger Joint / Q000473:pathology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000209:etiology; D007074:Immunoglobulin G; D008297:Male; D009220:Myositis / Q000209:etiology; D010396:Penicillamine / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D011507:Proteinuria / Q000209:etiology; D012867:Skin / Q000473:pathology; D013163:Splenomegaly / Q000209:etiology
D007074:Immunoglobulin G; D010396:Penicillamine; D001379:Azathioprine; D011241:Prednisone