Regulation of glucose metabolism in the lung: hexokinase-catalyzed phosphorylation, a rate-limiting step.
A measurement of uptake and phosphorylation of 2-deoxyglucose in rat lung slices under appropriately designed conditions showed that glucose metabolism in lung at the physiological concentration of the sugar will be limited by the rate of its phosphorylation and not by its transport into the cells.
D000818:Animals; D001692:Biological Transport; D005947:Glucose / Q000378:metabolism*; D006593:Hexokinase / Q000378:metabolism*; D066298:In Vitro Techniques; D008168:Lung / Q000378:metabolism*; D008297:Male; D010766:Phosphorylation; D051381:Rats; D011919:Rats, Inbred Strains
D006593:Hexokinase; D005947:Glucose