Kinetics of lead storage in teeth and bones: an epidemiologic approach.
Lead content in teeth of three Belgian populations with different exposures are considered in the framework of a three-compartment model describing lead exchanges in the body. The value of the first-order kinetic constant governing the transfer of lead from blood to teeth is shown to be approximately 1.85 yr-1, which is in good agreement with other studies using stable isotope tracers on a few subjects. Application of these findings to bones, where, contrary to teeth, remobilization processes cannot be neglected, leads to a tentative estimation of the rates of lead output from various kinds of bones, on the basis of epidemiologic data on their lead contents reported in the literature.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001530:Belgium; D001842:Bone and Bones / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D004781:Environmental Exposure; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007223:Infant; D007700:Kinetics; D007854:Lead / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D014070:Tooth / Q000032:analysis*
D007854:Lead