[Ultrastructural changes in the thyro- and somatotropes of hypothyroid rats as affected by exogenous somatotropin].
The state of somatotropic and thyrotropic adenohypophyseal functions of thyroidectomized rats after chronic injections of bovine somatotropin was studied. The adenohypophyseal somatotropin content increased by 22% per gland. The blood serum immunoreactive thyrotropin concentration was 0.925 +/- 0.063 microgram/ml in intact animals, 3.99 +/- 0.74 microgram/ml in thyroidectomized- and 1.27 +/- 0.19 microgram/ml in thyroidectomized rats, given somatotropin. According to electronic microscopy, hypothyrosis is characterized by an elevated functional somato- and thyrotrop activity, markedly decreased after somatotropin injection.
D000818:Animals; D013006:Growth Hormone / Q000494:pharmacology*; D007037:Hypothyroidism / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains; D013965:Thyroidectomy
D013006:Growth Hormone
Ul'trastrukturnye izmeneniia v tireo- i somatotrofakh gipotireoidnykh krys pod vliianiem ékzogennogo somatotropina.