Airway function in sarcoidosis: smokers versus nonsmokers.
Pulmonary function was measured in 24 sarcoidosis patients, 17 nonsmokers and 7 smokers. 12 (4 smokers) had evidence of small airway disease and 6 patients (3 smokers) had evidence of large airway disease. A significantly greater proportion of smokers had an increased closing volume, and closing volume appears to be the most sensitive test for small airway disease in sarcoidosis. However, 3 patients with normal closing volumes had evidence of small airway disease by forced expiratory flow rates or frequency dependence of compliance. We conclude that there is a high incidence of small airway disease in patients with sarcoidosis. There also appears to be a synergism between sarcoidosis and smoking that leads to a significant degree of hyperinflation of the lung.
D000328:Adult; D000368:Aged; D000402:Airway Obstruction / Q000175:diagnosis / Q000209:etiology; D000403:Airway Resistance; D001158:Arteries; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000503:physiopathology*; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D012137:Respiratory System / Q000503:physiopathology*; D012507:Sarcoidosis / Q000150:complications / Q000503:physiopathology*; D012907:Smoking
D010100:Oxygen