Low frequency amplitude modulated microwave fields change calcium efflux rates from synaptosomes.
Calcium (45Ca2+) efflux from preloaded synaptosomes was studied with a continuous perfusion technique and the rate constants of a two-phase efflux process calculated. When 16-Hz sinusoidally amplitude modulated 450-MHz microwave field (maximal incident intensity 0.5 mW/cm2, modulation depth 75%) was applied during the second phase, the rate constant increased by 38%. Unmodulated or 60-Hz modulated signals were not effective. This microwave field-induced change can be distinguished from CaCl2-stimulated 45Ca2+ efflux which is most probably derived intracellularly. These data suggest that the microwave-field induced change in calcium efflux probably did not involve intracellular calcium. Also, this change in the dynamic property of synaptosomes did not require gross anatomically intact tissue as a substrate for field-tissue interaction.
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000528:radiation effects; D002118:Calcium / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008854:Microscopy, Electron; D008872:Microwaves; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D013574:Synaptosomes / Q000378:metabolism* / Q000528:radiation effects / Q000648:ultrastructure
D002118:Calcium