Antitumor activity of a new antitumor antibiotic, stubomycin.
The antitumor activity of a new antibiotic, stubomycin, against various murine tumors was studied. Stubomycin showed antitumor activity against Sarcoma 180, IMC-carcinoma and Meth-A tumor. In particular, all of the mice inoculated i.p. with IMC-carcinoma were cured when they were given nine successive injections of stubomycin. Stubomycin also showed remarkable antitumor effects against Sarcoma 180 and Ehrlich ascites carcinoma when administered concomitantly with bleomycin.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D011090:Polyenes / Q000627:therapeutic use; D012510:Sarcoma 180 / Q000188:drug therapy
D000903:Antibiotics, Antineoplastic; D011090:Polyenes; C031780:stubomycin