Epsilon-aminocaproic acid myopathy. Report of a case and literature review.
A case of acute necrotic myopathy due to epsilon-aminocaproic acid (EACA) is described and compared with similar cases in the literature. This myopathy has only been noted after prolonged administration of the drug. The pathogenesis of this necrotic myopathy remains unclear, but our finds did not support a muscular vasculitis or an autoimmune reaction. Systematic preventive measures in patients with prolonged EACA therapy are proposed.
D000328:Adult; D000614:Aminocaproates / Q000009:adverse effects*; D015119:Aminocaproic Acid / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D004576:Electromyography; D006801:Humans; D008297:Male; D009132:Muscles / Q000473:pathology; D009212:Myoglobinuria / Q000139:chemically induced; D009336:Necrosis; D009468:Neuromuscular Diseases / Q000139:chemically induced*; D013345:Subarachnoid Hemorrhage / Q000188:drug therapy
D000614:Aminocaproates; D015119:Aminocaproic Acid