The effect of cadmium and manganese on the distribution of iron-59 in partially-hepatectomized rats.
The distribution of iron-59 in blood at various time intervals was studied in sham and partially-hepatectomized rats after a single intravenous injection of 59Fe (III) citrate. A significant difference was observed in the rate of disappearance and reappearance of iron-59 in circulation. Administration of cadmium and manganese at a concentration of 0.5 and 2 mg/kg b.wt., respectively, did not cause any significant change in this pattern. A significant decrease in iron-59 incorporation in the liver of hepatectomized rat was produced by cadmium while manganese had no effect.
D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D006498:Hepatectomy; D007501:Iron / Q000097:blood* / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008115:Liver Regeneration; D008297:Male; D020149:Manganese Poisoning; D051381:Rats
D002104:Cadmium; D007501:Iron