Influence of dietary restriction and protein deficiency on plasma half-life and tissue distribution of tetracycline in rats.
1. The effects of dietary restriction and protein deficiency on plasma half-life and tissue distribution of tetracycline were studied in rats by feeding either a 20% protein diet in restricted quantity or a 9% protein diet ad lib and compared with rats given a 20% protein diet ad lib (control group). 2. It was observed that half-life of tetracycline was shortened and that plasma and tissue Cmin levels at steady-state were lower in undernourished rats. Tissue concentrations in liver, kidney, muscle and bone correlated well with plasma levels. A high degree of correlation was also observed between plasma and tonsillar concentrations of tetracycline in human subjects. 3. These studies indicate that undernourished subjects may require an altered dosage regimen of tetracycline to maintain effective steady-state concentrations of the drug.
D000293:Adolescent; D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism; D001835:Body Weight; D004044:Dietary Proteins / Q000008:administration & dosage; D005508:Food Deprivation / Q000502:physiology*; D006207:Half-Life; D006801:Humans; D008099:Liver / Q000032:analysis / Q000378:metabolism; D008297:Male; D014066:Palatine Tonsil / Q000032:analysis; D011488:Protein Deficiency / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013752:Tetracycline / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D014018:Tissue Distribution
D000900:Anti-Bacterial Agents; D004044:Dietary Proteins; D013752:Tetracycline