Hepatocellular ligandin during N-2-fluorenylacetamide carcinogenesis.
Ligandin was decreased by 75% as determined immunologically and by glutathione-S-transferase or steroid isomerase activities in rat hepatocellular carcinomas induced by exposure to N-2-fluorenylacetamide. Minor variable differences in ligandin levels were noted between the putative, premalignant nodules induced by this regimen and normal liver.
D015073:2-Acetylaminofluorene / Q000009:adverse effects*; D000818:Animals; D005982:Glutathione Transferase / Q000032:analysis*; D008099:Liver / Q000032:analysis; D008113:Liver Neoplasms / Q000032:analysis* / Q000139:chemically induced*; D008297:Male; D009374:Neoplasms, Experimental / Q000032:analysis / Q000139:chemically induced; D011230:Precancerous Conditions / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D013251:Steroid Isomerases / Q000378:metabolism
D015073:2-Acetylaminofluorene; D005982:Glutathione Transferase; D013251:Steroid Isomerases