The mineralocorticoid hormone pathways in hypertension with hyperaldosteronism.
Simultaneous measurement of the 0800-hr plasma concentrations of deoxycorticosterone (DOC), corticosterone (B), 18-hydroxycorticosterone (18-OHB), aldosterone, 18-hydroxydeoxycorticosterone (18-OHDOC) and cortisol (F) in four types of primary aldosteronism provides evidence for primary adrenal disease. Elevated DOC with normal F concentrations in the presence of elevated 18-OHB and aldosterone, and suppressed renin concentration suggests a primary adrenal abnormality of the zona glomerulosa (ZG). Steroid production by the zona fasciculata (ZF), F, 18-OHDOC, and most often B, is normal. These patterns exist only for primary adrenal hyperplasia, aldosterone-producing adenoma (APA), and aldosterone-producing adrenocortical carcinoma (AP-Ca). Elevated DOC levels are rarely found in patients with idiopathic hyperaldosteronism (IHA or adrenal hyperplasia) and suggest that IHA is not a primary adrenal disorder and should be excluded from the syndrome of primary aldosteronism as they have been heretofore.
D015070:18-Hydroxydesoxycorticosterone / Q000097:blood; D000236:Adenoma / Q000150:complications / Q000175:diagnosis; D000450:Aldosterone / Q000097:blood; D003345:Corticosterone / Q000097:blood; D003900:Desoxycorticosterone / Q000097:blood; D006854:Hydrocortisone / Q000097:blood; D006929:Hyperaldosteronism / Q000097:blood* / Q000150:complications; D006973:Hypertension / Q000097:blood* / Q000150:complications; D008901:Mineralocorticoids / Q000097:blood*
D015070:18-Hydroxydesoxycorticosterone; D008901:Mineralocorticoids; D003900:Desoxycorticosterone; D000450:Aldosterone; D003345:Corticosterone; D006854:Hydrocortisone