[Coronary artery dilatation induced by isosorbide dinitrate injection (author's transl)].
Twenty-six patients were given 3 mg isosorbide dinitrate either by direct intra-coronary injection (17 patients) or by intravenous injection ( patients), 5 minutes after an injection of 0.4 mg methylergometrine. In all 26 patients isosorbide dinitrate dilated the coronary arteries to a diameter that was 26% greater than the smallest diameter observed with methylergometrine and 14.8% greater than the basal diameter. The response was highly significant at 30 seconds, maximal at 2 minutes and lasted more than 10 minutes. At the dosage level used in this study, there was no significant difference between the two groups of patients. However, a rapid fall in systemic arterial pressure was noted after peripheral intravenous injection.
D003331:Coronary Vessels / Q000187:drug effects*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D014664:Vasodilation / Q000187:drug effects*
D007548:Isosorbide Dinitrate
Action coronarodilatatrice de l'isosorbide dinitrate injectable.