Possible prevention from the progression of cardiotoxicity in adriamycin-treated rabbits by coenzyme Q10.
The cumulative dose-dependent cardiotoxicity induced by doxorubicin (adriamycin, ADR) and its possible prevention by coenzyme Q10 (CoQ10) were studied in rabbits. In the group that received ADR alone, ADR dose-dependent electrocardiography (ECG) abnormalities and severe myocardial damage on electron microscopic examination were observed. In the group that received ADR + CoQ10, these alterations occurred in lesser degree, and ECG changes seemed to be improved. The results indicated that CoQ10 might prevent the progression of cardiotoxicity in ADR treated rabbits.
D000818:Animals; D004317:Doxorubicin / Q000633:toxicity*; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D009206:Myocardium / Q000648:ultrastructure; D011817:Rabbits; D014451:Ubiquinone / Q000494:pharmacology*
D014451:Ubiquinone; D004317:Doxorubicin