[Hypoglycemic effect of excess thyroid hormones in insulin deficiency].
In experiments on rats with severe streptozotocin diabetes, administration of high doses of L-thyroxine reduces hyperglycemia and glucosuria. It is postulated that glucose utilization by extrahepatic tissues does not depend on direct insulin action and that the Randle cycle is ineffective in hypermetabolism.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006029:Glycosuria / Q000378:metabolism; D006943:Hyperglycemia / Q000378:metabolism; D006980:Hyperthyroidism / Q000378:metabolism*; D007003:Hypoglycemia / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013974:Thyroxine / Q000008:administration & dosage
D013974:Thyroxine
Gipoglikemicheskiĭ éffekt izbytka tireoidnykh gormonov v usloviiakh defitsita insulina v organizme.