The effects of cimetidine on serum calcium and parathyroid hormone levels in primary hyperparathyroidism.
1 Cimetidine has been reported to reduce serum calcium and parathyroid hormone (PTH) levels in primary hyperparathyroidism, but some studies have reported negative findings. 2 A double-blind, controlled trial of cimetidine in this condition was, therefore, conducted. Eight patients were given cimetidine and placebo for 2 months each, in random order. Only one patient showed a significant fall in serum calcium on cimetidine and no patient showed a fall in PTH levels. 3 In addition, eight patients were studied during a 48 h continuous intravenous infusion of cimetidine. The first five patients exhibited no effect of the drug on either calcium of PTH levels, but in the sixth there appeared to be a dose-dependent suppression of PTH. The seventh and eighth patients were, therefore, given a higher dose of the drug but it failed to suppress calcium or PTH values. 4 It is concluded that cimetidine is not of value in primary hyperparathyroidism.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D002118:Calcium / Q000097:blood*; D002927:Cimetidine / Q000627:therapeutic use*; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood / Q000188:drug therapy*; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*
D006146:Guanidines; D010281:Parathyroid Hormone; D002927:Cimetidine; D002118:Calcium