Bioavailability study on a new slow-release formulation of ketoprofen.
Four healthy subjects volunteered for a crossover bioavailability study to compare the rate and extent of absorption of plain capsules and new slow-release capsules of ketoprofen. The formulations were administered in two consecutive 4-day periods at the following dose schedules: 2 x 50 mg plain capsules t.i.d. and 150 mg slow-release capsules b.i.d. The plasma levels profile of unchanged ketoprofen was assessed by GLC during the 4th day of treatment with each formulation. The absorption from slow-release capsules was slower and more sustained than from plain capsules but almost complete. The bioavailability properties of new slow-release capsules of ketoprofen appear suitable for clinical use with reduced frequency of daily dosing.
D000328:Adult; D001682:Biological Availability; D003692:Delayed-Action Preparations; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D010666:Phenylpropionates / Q000378:metabolism*
D003692:Delayed-Action Preparations; D010666:Phenylpropionates; D007660:Ketoprofen