Selective affinity of dimethyl sulphoxide (DMSO) and 2-amino-4-phenylsulphonylbenzenesulphonamide (NSD 3004) for the large intestinal mucosa of mice.
Whole-body autoradiography of 14C-labelled dimethyl sulphoxide and 35S-labelled 2-amino-4-phenylsulphonylbenzenesulphonamide revealed a selective accumulation of labelled substance in the large intestinal mucosa of mice. The mechanism of accumulation is discussed with regard to previous results on sulphone-containing compounds with tissue-specific distribution patterns.
D000818:Animals; D000927:Anticonvulsants / Q000378:metabolism*; D004121:Dimethyl Sulfoxide / Q000378:metabolism*; D005260:Female; D007413:Intestinal Mucosa / Q000378:metabolism; D007420:Intestine, Large / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D013424:Sulfanilamides / Q000378:metabolism*; D000096926:Benzenesulfonamides
D000927:Anticonvulsants; D004121:Dimethyl Sulfoxide; D013424:Sulfanilamides; C000210:2-amino-4-phenylsulfonylbenzenesulfonamide; D000096926:Benzenesulfonamides