The effect of oral hydralazine on the pulmonary hemodynamics of patients with pulmonary foreign body granulomatosis.
Six patients, age 32 +/- 5 yr, had biopsy-proven foreign body granulomatosis secondary to the chronic injection of crushed, suspended pentazocine tablets. All patients complained of exercise-induced dyspnea. Measurements were made of mean pulmonary artery pressures (PAP), cardiac outputs (CO), pulmonary vascular resistance (PVR), and systemic vascular resistance (SVR) at rest and following 9 minutes of steady-state upright exercise. Following this, 50 mg of hydralazine was administered orally. The exercise PAP increased, and exercise PVR following hydralazine rose also. Exercise-induced dyspnea improved in all patients. In patients with foreign body granulomatosis, exercise-induced increases in PAP and PVR are common. This increase in PAP and PVR can be ameliorated somewhat by the acute oral administration of hydralazine. Exercise-induced dyspnea also improves.
D000284:Administration, Oral; D000328:Adult; D004417:Dyspnea / Q000188:drug therapy; D006099:Granuloma / Q000150:complications* / Q000209:etiology; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006830:Hydralazine / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D006976:Hypertension, Pulmonary / Q000188:drug therapy*; D008297:Male; D005082:Physical Exertion; D012146:Rest; D013627:Talc / Q000009:adverse effects
D013627:Talc; D006830:Hydralazine