Transplacental passage of dichloromethane and carbon monoxide.
Maternal blood dichloromethane concentrations were higher than fetal blood dichloromethane concentrations and maternal and fetal blood carbon monoxide concentrations were the same in pregnant rats exposed to 500 ppm of dichloromethane. Fetal blood carbon monoxide concentrations were higher than maternal blood carbon monoxide concentrations in pregnant rats exposed to 20 ppm of carbon monoxide. These results show that maternal exposure to dichloromethane is accompanied by fetal exposure to both dichloromethane and carbon monoxide.
D000818:Animals; D002248:Carbon Monoxide / Q000378:metabolism*; D005260:Female; D006843:Hydrocarbons, Chlorinated / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D008752:Methylene Chloride / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D006843:Hydrocarbons, Chlorinated; D008752:Methylene Chloride; D002248:Carbon Monoxide