Towards higher resolution in biomolecular electron microscopy.
Technical advances in electron microscopy have opened up exciting prospects to peer into the finest details of biomolecular organisation. Unfortunately, the potential of today's instruments cannot be fully exploited due to the intrinsic susceptibility of biological specimens to dehydration and electron irradiation. A survey is given of recent activities and trends aimed at overcoming these limitations.
D000818:Animals; D001704:Biopolymers; D002918:Chymotrypsin; D003208:Concanavalin A; D003890:Desiccation; D006454:Hemoglobins; D006801:Humans; D007782:Lactoglobulins; D046911:Macromolecular Substances; D008854:Microscopy, Electron / Q000379:methods; D008968:Molecular Conformation; D009211:Myoglobin
D001704:Biopolymers; D006454:Hemoglobins; D007782:Lactoglobulins; D046911:Macromolecular Substances; D009211:Myoglobin; D003208:Concanavalin A; D002918:Chymotrypsin