Placental transfer and metabolism of purines and nucleosides in the pregnant guinea pig.
The placental transfer and metabolism of several purines and nucleosides have been investigated using an artificially perfused guinea-pig placenta. A model describing transfer and metabolism in the uteroplacental unit is constructed and applied. Measurements of oxypurines and guanine have been performed in vivo in the blood of pregnant guinea pigs and their fetuses. It appears that only the oxypurines and, to a lesser extent, guanine are present in the maternal and fetal circulations. These purines could be involved in transfer from mother to fetus and used for salvage in the fetal tissues.
D000818:Animals; D001692:Biological Transport; D004912:Erythrocytes / Q000032:analysis; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006168:Guinea Pigs; D008954:Models, Biological; D009705:Nucleosides / Q000378:metabolism*; D010477:Perfusion; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal; D011687:Purines / Q000097:blood / Q000378:metabolism*
D009705:Nucleosides; D011687:Purines