Chronic anicteric intrahepatic cholestasis associated with ankylosing spondylitis. Beneficial treatment by clofibrate.
A case of anicteric idiopathic intrahepatic cholestasis in association with ankylosing spondylitis is described. No primary cause for the cholestatic syndrome was found and the liver histology was repeatedly normal. Results of treatment with clofibrate (2 g daily) were very satisfactory, as the symptoms and signs of cholestasis had gradually subsided. Discontinuation of the treatment was followed rapidly by a recurrence of the cholestasis with a new improvement after restarting treatment. The beneficial mechanism of action of clofibrate on the intrahepatic cholestasis in the case described remains speculative.
D000328:Adult; D002780:Cholestasis, Intrahepatic / Q000150:complications* / Q000188:drug therapy; D002908:Chronic Disease; D002994:Clofibrate / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D013167:Spondylitis, Ankylosing / Q000150:complications*
D002994:Clofibrate