[Influence of the coagulase reaction on the leukotactic effect of Staphylococcus aureus in artificial body cavities of rabbits].
It was attempted, to determine the influence of coagulase-induced coagula on the leukotactic effects of Staphylococcus aureus in experimental subcutaneous body-cavities (KK) of rabbits. Purified staphylococcal coagulase mediated a partial coagulation in the KK when fibrinogen had been added. The coagula delayed the leukotaxis into the KK after the injection of (killed) encapsulated and non-encapsulated S. aureus extracted with 6 M guanidiniumchloride (Fig. 1), as well as after the injection of the untreated (viable) staphylococci (Fig. 2). The coagula also delayed phagocytosis, at least during the first hours of the experiments (Fig. 3).
D000818:Animals; D002634:Chemotaxis, Leukocyte; D003030:Coagulase / Q000378:metabolism*; D005340:Fibrinogen / Q000494:pharmacology; D010587:Phagocytosis; D011817:Rabbits; D013211:Staphylococcus aureus / Q000201:enzymology / Q000502:physiology*
D003030:Coagulase; D005340:Fibrinogen
Einfluss der Koagulasereaktion auf die leukotaktische Wirkung von Staphylococcus aureus in "künstlichen Körperhöhlen" von Kaninchen.