[Lipid dependence of the activity of cytochrome P-450 from microsomes of rat liver by the phosphatidylcholine transfer protein from bovine liver].
The lipid dependence of hydroxylase and demethylase activities of microsomal cytochrome P-450 was studied, using purified phosphatidylcholine transfer protein from bovine liver. In the presence of this protein exogeneous phosphatidylcholine was shown to reactivate cytochrome P-450 inactivated earlier with lysophosphatidylcholine.
D000727:Androgen-Binding Protein; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002417:Cattle; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008244:Lysophosphatidylcholines / Q000494:pharmacology; D008862:Microsomes, Liver / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000494:pharmacology*; D049294:Phospholipid Transfer Proteins; D060789:Prostatein; D051381:Rats; D060765:Secretoglobins; D014598:Uteroglobin; D060788:Mammaglobin B
D000727:Androgen-Binding Protein; D002352:Carrier Proteins; D003577:Cytochrome P-450 Enzyme System; D008244:Lysophosphatidylcholines; D010713:Phosphatidylcholines; D049294:Phospholipid Transfer Proteins; D060789:Prostatein; D060765:Secretoglobins; D014598:Uteroglobin; C511484:Scgb1d2 protein, rat; C511483:Scgb1d4 protein, rat; C556468:Scgb2a1 protein, rat; D060788:Mammaglobin B
Izuchenie lipidnoĭ zavisimosti aktivnosti tsitokhroma P-450 mikrosom pecheni krys s pomoshch'iu fosfatidilkholinperenosiashchego belka pecheni krupnogo rogatogo skota.