Inhibition of thrombin cleavage of fibrinogen by polyestradiol phosphate; interaction with the crucial arginine residues in fibrinogen required for enzymic cleavage.
1. Polyestradiol phosphate (PEP) has been demonstrated to have inhibitory activity against hyaluronidase, acid phosphatase and alkaline phosphatase (Fernö et al., 1958). 2. PEP has a marked inhibitory action against thrombin in the blood clotting reaction in which thrombin cleaves four fibrinopeptides from fibrinogen resulting first in the formation of monomeric fibrin and then polymeric fibrin fibrils (Baughman, 1970; Magnusson, 1970).
D001120:Arginine / Q000378:metabolism; D004958:Estradiol / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D005340:Fibrinogen / Q000378:metabolism*; D007700:Kinetics; D013917:Thrombin / Q000037:antagonists & inhibitors*
D004958:Estradiol; D005340:Fibrinogen; D001120:Arginine; D013917:Thrombin; C008958:polyestradiol phosphate