Gastrin release and gastric secretion induced by dimethylxanthine in man.
Gastrin release and gastric secretion in response to i.v. dimethylxanthine (2 mg/kg for 5 min followed by a 55-min infusion of 2.5 mg/kg) were studied in 25 normal subjects. Gastrin release was significantly stimulated, whereas gastric acid and pepsin secretion was inhibited. The adenylcyclase activation may, therefore, play a role in the mechanism of gastrin release. Moreover, dimethylxanthine seems to be a useful aid in studies on G-cell function in man.
D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism*; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D010431:Pentoxifylline; D013805:Theobromine / Q000031:analogs & derivatives*
D005755:Gastrins; D013805:Theobromine; D010431:Pentoxifylline