Relationship between neuron density and oxygen consumption in the guinea pig paramedian cortex during development.
Development-related changes in cortical consumption in the guniea pig were studied with respect to changes in neuronal density. Total oxygen consumption was directly related to neuron density, with 5-day-old cortex tissue possessing significantly more neurons per unit area than mature cortical blocks. In contrast, mature cortical neurons utilized more oxygen than did 5-day-old cortical neurons. The results indicate that developmental changes in both cortical neuron density and cellular metabolic rates affect oxygen consumption patterns in developing guinea pig brain tissue.U
D000375:Aging; D000818:Animals; D002452:Cell Count; D002540:Cerebral Cortex / Q000166:cytology* / Q000378:metabolism; D004734:Energy Metabolism; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D010101:Oxygen Consumption