Localization of monoamine oxidases A and B in primate brains relative to neuron-specific and non-neuronal enolases.
Using serotonin and phenylethylamine deamination as measures of MAO A and MAO B activity respectively, positive correlations were observed between the activities of MAO A and MAO B in different areas of rhesus monkey and human brains. When the activities of MAO A and MAO B were compared with those of neuron-specific enolase and nonneuronal enolase (isozymes which are markers for neurons and glia), a slight but non-significant correlation was observed, suggesting that a simple distribution of MAO A in neurons and MAO B in glia is unlikely. This conclusion is supported by studies using synaptosomes, but contrasts with that from investigations of MAO from peripheral tissues, where experiments indicate that MAO A is predominantly localized in neurones.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002522:Chlorocebus aethiops; D006801:Humans; D008253:Macaca mulatta; D008995:Monoamine Oxidase / Q000378:metabolism*; D009474:Neurons / Q000201:enzymology*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*; D013045:Species Specificity; D014018:Tissue Distribution
D008995:Monoamine Oxidase; D010751:Phosphopyruvate Hydratase