Comparison of the bronchodilator effect of oral fenoterol and ephedrine in asthmatic children.
Sixteen children with asthma took part in a double-blind, crossover comparison study of single doses of fenoterol (2.5, 5.0 and 7.5 mg), ephedrine (24 mg) and placebo. Spirometry was performed before drug administration and then hourly for six hours thereafter. Mean values were plotted for six hours after dur administration. All active drugs were superior to placebo. The greatest differences were in FEF25-75 spirometry levels although the differences for FEV1 did reach statistical significance. The 7.5 mg dose of fenoterol was superior to all other active drug categories. Although effects of tremor and nausea were minimal, significant tachycardia and palpitations were noted with the 5.0 mg and 7.5 mg doses of fenoterol.
D000284:Administration, Oral; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D002648:Child; D004809:Ephedrine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004983:Ethanolamines / Q000008:administration & dosage*; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008450:Maximal Midexpiratory Flow Rate; D010919:Placebos; D011674:Pulse / Q000187:drug effects; D013147:Spirometry; D014797:Vital Capacity / Q000187:drug effects
D001993:Bronchodilator Agents; D004983:Ethanolamines; D010919:Placebos; D005280:Fenoterol; D004809:Ephedrine