Levels of trimethoprim and sulfamethoxazole in human oviduct mucosa and plasma.
The oviductal and plasma levels of trimethoprim (TMP) and sulfamethoxazole (SMZ) were studied in 9 women after oral and i.v. administration of a drug combination (Eusaprim R, Wellcome Foundation Ltd). The concentration of TMP in a healthy endosalpinx was found to be twice as high (4.7 microgram/g, range 2.8-8.3) as in plasma (2.6 microgram/ml, range 2.1-3.6). Conversely, the endosalpingeal level of SMZ (38 microgram/g, range 12-65) was about half that in plasma (77 microgram/ml, range 58-95). The agar well diffusion method was used for the concentration determinations. The specimens were collected during surgery for non-infectious genital diseases. The implication of treatment by the given drugs is discussed.
D004338:Drug Combinations; D005187:Fallopian Tubes / Q000378:metabolism*; D005260:Female; D006801:Humans; D009092:Mucous Membrane / Q000378:metabolism; D013420:Sulfamethoxazole / Q000097:blood / Q000378:metabolism*; D014295:Trimethoprim / Q000097:blood / Q000378:metabolism*
D004338:Drug Combinations; D014295:Trimethoprim; D013420:Sulfamethoxazole