Amiodarone-induced cornea verticillata.
Among 37 patients treated with amiodarone, an antiarrhythmic drug, a typical keratopathy developed in 35, none of whom had ocular complaints. The keratopathy resembled that seen with Fabry's disease and chloroquine use, as did the membrane-bound lamellar bodies detected by electron microscopy in all layers of the corneal epithelium in the one patient with marked keratopathy in whom a corneal biopsy was performed; membrane-bound bodies, mostly granular, were also noted within this patient's stromal keratocytes. The possible pathogenesis of the keratopathy as a type of drug-induced lipidosis is discussed.
D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D001572:Benzofurans / Q000009:adverse effects*; D003315:Cornea / Q000473:pathology* / Q000648:ultrastructure; D003316:Corneal Diseases / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008064:Lipidoses / Q000139:chemically induced; D008854:Microscopy, Electron; D008875:Middle Aged
D001572:Benzofurans; D000638:Amiodarone