Leukapheresis and granulocyte transfusion.
Newer cell separators can collect more PMN, especially using macromolecular agents and steroid stimulation of donors. Proper indications for PMN transfusion are severe neutropenia and sepsis, or certain localized infections, when prolonged marrow aplasia is expected. Optimal dosage is at least 2 x 10(10) PMN per day, probably more. There is a need for more accurate definition of clinical indications for PMN support, for still greater PMN yields from leukapheresis, and for better PMN storage capability.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000818:Animals; D000925:Anticoagulants / Q000097:blood; D001424:Bacterial Infections / Q000628:therapy; D001782:Blood Donors; D001787:Blood Group Incompatibility / Q000097:blood; D001793:Blood Preservation; D001800:Blood Specimen Collection / Q000295:instrumentation / Q000379:methods; D001803:Blood Transfusion / Q000379:methods*; D002983:Clinical Competence; D004285:Dogs; D006098:Granulocytes / Q000187:drug effects / Q000637:transplantation*; D006650:Histocompatibility Testing; D006801:Humans; D007937:Leukapheresis / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D007958:Leukocyte Count; D046911:Macromolecular Substances; D009503:Neutropenia / Q000188:drug therapy / Q000628:therapy; D065227:Transfusion Reaction
D000305:Adrenal Cortex Hormones; D000925:Anticoagulants; D046911:Macromolecular Substances