[Sulfalene kinetics in the blood and cerebrospinal fluid in arachnoiditis].
The kinetics of free sulfalene in the blood and cerebrospinal fluid was studied in patients suffering from chronic arachnoiditis without marked inflammation signs on the part of arachnoid after a single intake of 2 g of the drug. It was found that administration of the drug in this dose once a week is quite justified and that sulfalene penetrates well in the cerebrospinal fluid. Upon administering large doses of the drug its absorption from the gastrointestinal tract declines. Sulfalene is eliminated from the cerebrospinal fluid more slowly than from the blood. High enough drug concentration is maintained in the cerebrospinal fluid for 7 days.
D000293:Adolescent; D000328:Adult; D001100:Arachnoiditis / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D005609:Free Radicals; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D013415:Sulfalene / Q000378:metabolism*; D013424:Sulfanilamides / Q000378:metabolism*; D013997:Time Factors
D005609:Free Radicals; D013424:Sulfanilamides; D013415:Sulfalene
Kinetika sul'falena v krovi i spinnomozgovoĭ zhidkosti bol'nykh arakhnoiditom.