[Characteristics of the antigenic composition of the cells of intra- and interspecific hybrids of murine hepatoma XXIIa].
Hybrids of cultivated mouse hepatoma XXIIA cells were studied for the presence of species-specificity antigens. Forssman antigen, and antigen similar to human B-isoantigen. The cells of MGXXIIA hepatoma, clone culture of L mouse fibroblasters and RJK hamster cells were used as parental cells. To obtain hybrids, use was made of whole hepatoma cells. Subject to study were 1 clone of microcellular intra-species, 2 whole cell clones and 2 clones of microcellular interspecies hepatoma hybrids. Antigens in hybrid cells were studied with the rapid cytotoxic test, cell agglutination and antibody absorption tests. Unlike cultivated mouse cells, only Forssman antigen was detected in cultivated hamster cells. Species-specificity antigens, Forssman antigen and antigen similar to human B-isoantigen were revealed in the cells of both the intraspecies and all interspecies hepatoma hybrids.
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis*; D002459:Cell Fusion; D002460:Cell Line; D002478:Cells, Cultured; D006224:Cricetinae; D005577:Forssman Antigen / Q000032:analysis; D006822:Hybrid Cells / Q000276:immunology*; D008114:Liver Neoplasms, Experimental / Q000276:immunology*; D051379:Mice; D009368:Neoplasm Transplantation; D013045:Species Specificity
D000951:Antigens, Neoplasm; D005577:Forssman Antigen
Kharakteristika antigennogo sostava kletok vnutri- i mezhvidovykh gibridov myshinoĭ gepatomy XXIIa.