[Protective effect of the psychotropic preparations diazepam, sodium oxybutyrate and mebikar in experimental arrhythmias].
It was shown that the psychotropic agents diazepam (1-2 mg/kg), sodium hydroxybutyrate (50-100 mg/kg) and mebicar (250-500 mg/kg) exert a protective action in experimental arrhythmias. This effect is determined by the ability of the drugs to reduce intoxication phenomena, as well as by their antihypoxic and stress-protective properties. On the other hand, the drugs exert an antiarrhythmic effect proper, interfering with potassium ion balance. The protective effects of diazepam, sodium hydroxybutyrate and mebicar enable their application in combined therapy of arrhythmias of varying genesis.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D001736:Biureas / Q000627:therapeutic use*; D002122:Calcium Chloride; D002415:Cats; D003975:Diazepam / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D051381:Rats; D012978:Sodium Oxybate / Q000627:therapeutic use*; D013328:Strophanthins; D014149:Tranquilizing Agents / Q000627:therapeutic use*; D014882:Water-Electrolyte Balance / Q000187:drug effects
D001736:Biureas; D006885:Hydroxybutyrates; D013328:Strophanthins; D014149:Tranquilizing Agents; C015979:mebikar; D012978:Sodium Oxybate; D002122:Calcium Chloride; C029082:strophanthin K; D003975:Diazepam
O zashchitnom éffekte psikhotropnykh preparatov diazepama, natriia oksibutirata i mebikara pri éksperimental'nykh aritmiiakh.