Multiple endocrine neoplasia. Pituitary adenoma, multicentric papillary thyroid carcinoma, bilateral carotid body paraganglioma, parathyroid hyperplasia, gastric leiomyoma, and systemic amyloidosis.
Multiple endocrine neoplasia in a 70-year-old woman are described. The findings include a nonfunctioning pituitary adenoma, a multicentric papillary thyroid carcinoma, bilateral carotid body paragangliomas, parathyroid hyperplasia, gastric leiomyoma and systemic amyloidosis. A study of the kindred revealed that two family members, a daughter and a granddaughter, have clinical and radiographic evidence of pituitary tumors and bilateral carotid body paragangliomas, suggesting that this may represent a genetically determined syndrome inherited as an autosomal dominant.
D000236:Adenoma / Q000175:diagnosis / Q000235:genetics; D000328:Adult; D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis / Q000235:genetics; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000235:genetics; D002345:Carotid Body Tumor / Q000175:diagnosis / Q000235:genetics; D004700:Endocrine System Diseases / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007889:Leiomyoma / Q000175:diagnosis / Q000235:genetics; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics; D010235:Paraganglioma / Q000175:diagnosis / Q000235:genetics; D010279:Parathyroid Diseases / Q000175:diagnosis / Q000235:genetics; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000235:genetics; D012658:Sella Turcica / Q000473:pathology; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics; D013577:Syndrome; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000235:genetics