The impact of growth pattern on survival in non-Hodgkin's lymphomas classified according to Lukes and Collins.
203 cases of non-Hodgkin's lymphomas assigned as follicle centre cell (FCC) type according to the classification of Lukes and Collins (1975) were analyzed according to growth pattern. Nodular cases had a better prognosis than diffuse ones even within a certain cell type. The abundance of parafollicular lymphocytes was a better criterium of nodularity than prominence of venules. Degrees of nodularity was best scored according to distribution of diffuse and nodular areas. Prognosis was better with a higher degree of nodular growth even within a certain cytological cell type. Therefore it is proposed that scoring according to different degrees of nodularity has a high prognostic impact and could be an alternative to scoring according to cell type within the group of follicle centre cell lymphomas.
D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008223:Lymphoma / Q000401:mortality* / Q000473:pathology*; D014699:Venules / Q000473:pathology