Viscometric analysis of effects of cytochalasins on in vitro polymerization and depolymerization of microtubules.
Nineteen cytochalasins including 6 natural cytochalasins, 2 natural aspochalasins, 7 natural chaetoglobosins and 4 their acetates were investigated by viscometry to examine their effects on in vitro polymerization and depolymerization of microtubules. Cytochalasin A was proved as an only active cytochalasin, confirming the studies of Himes et al., and others showed very weak or no noticeable effects. This results indicate that a wide range of effects of cytochalasins are not related to interactions with microtubules.
D000818:Animals; D001704:Biopolymers / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D003572:Cytochalasins / Q000494:pharmacology*; D066298:In Vitro Techniques; D008870:Microtubules / Q000378:metabolism*; D013552:Swine; D013997:Time Factors; D014404:Tubulin / Q000378:metabolism; D014783:Viscosity
D001704:Biopolymers; D003572:Cytochalasins; D014404:Tubulin