Influences of operative stress on cell-mediated immunity and on tumor metastasis and their prevention by nonspecific immunotherapy: experimental studies in rats.
Influences of operative stress on nonspecific cell-mediated immunity and on liability to tumor metastasis and preventive effects thereon of a nonspecific immunopotentiator OK-432 were examined. Syngeneic female SD rats were inoculated SC with 200 mg of a transplantable mammary carcinoma MRMT-1 at the dorsal flank. After 2 weeks the tumor was surgically excised simply or combined with 30-min laparotomy. It was revealed by follow-up examination that the laparotomy stress significantly increased incidence of postoperative lung metastasis. It was found that PHA-induced blastogenesis of peripheral lymphocytes was markedly reduced in the early period following laparotomy. Preoperative or post-operative (especially the former) administration of OK-432 was effective for preventing both the postlaparotomy facilitation of lung metastasis and the postlaparotomy reduction in PHA lymphoblastogenesis.
D000818:Animals; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D001688:Biological Products / Q000627:therapeutic use*; D005260:Female; D007111:Immunity, Cellular; D007167:Immunotherapy; D007813:Laparotomy / Q000009:adverse effects; D008175:Lung Neoplasms / Q000401:mortality / Q000517:prevention & control / Q000556:secondary*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008325:Mammary Neoplasms, Experimental / Q000601:surgery*; D009368:Neoplasm Transplantation; D010835:Phytohemagglutinins / Q000494:pharmacology; D010844:Picibanil / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000276:immunology*; D013997:Time Factors
D001428:Bacterial Vaccines; D001688:Biological Products; D010835:Phytohemagglutinins; D010844:Picibanil