The effect of polyunsaturated phosphatidylcholine on liver phosphoglyceride synthesis.
Experimental evidence is reported that shows a noticeable stimulation of the rate of lecithin synthesis in vitro from phosphorylcholine in liver microsomes by the addition of a polyunsaturated soybean phospholipid material (EPL). When the synthesis of lecithin takes place from cytidine-diphosphate-choline no stimulation takes place. The synthesis of phosphatidylethanolamine from phosphorylethanolamine is not stimulated by this addition. Suggestion is made that lipid components of the EPL preparation exert a stimulatory effect at the level of the rate-limiting step of lecithin synthesis, catalyzed by cytidylyltransferase enzymes.
D000818:Animals; D005994:Glycerophosphates / Q000096:biosynthesis*; D008055:Lipids / Q000096:biosynthesis; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008566:Membranes / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D010713:Phosphatidylcholines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions / Q000378:metabolism
D005994:Glycerophosphates; D008055:Lipids; D010713:Phosphatidylcholines