[KCl-tumor extracts in the electrophoretic mobility test [EMT]. - Clinical relevance to diagnosis of gastric cancer (author's transl)].
Using KCl-tumor extracts from various human carcinomas we tried to improve the reliability of the electrophoretic mobility test (EMT). 25 of 26 patients with histologically proven gastric cancer showed a correct positive reaction if tested with gastric cancer tumor extracts. 44 of 50 healthy controls showed negative test results when tested with the same tumor extracts. Migration inhibition in the tumor patients differed significantly from that of the healthy controls (p less than or equal to 0,05). Specificity was verified by testing gastric cancer patients with extracts from tumors of the same organ as well as different carcinomas: the most pronounced migration inhibition was observed, when gastric carcinoma extracts were used. Tumor extracts of different histogenesis showed weaker or negative reactions. Inflammatory lesions reduce the reliability of the test system: of 17 patients with ulcers or erosive gastritis 9 had false positive reactions.
D000328:Adult; D000368:Aged; D002464:Cell Migration Inhibition; D005189:False Positive Reactions; D006801:Humans; D007249:Inflammation / Q000175:diagnosis; D008214:Lymphocytes / Q000276:immunology; D008875:Middle Aged; D009928:Organ Specificity; D011189:Potassium Chloride; D013274:Stomach Neoplasms / Q000175:diagnosis*; D014020:Tissue Extracts
D014020:Tissue Extracts; D011189:Potassium Chloride
KCl-Tumorextrakte im Elektrophorese-Mobilitätstest (EMT). - Klinische Wertigkeit in der Diagnostik des Magenkarzinoms.