Hypothalamic and pituitary cytosol receptors to 5 alpha-dihydrotestosterone and oestradiol-17 beta during the prepubertal period in the male lamb.
Hypothalamic and pituitary cytosol receptors to 5 alpha-dihydrotestosterone (DHT) and oestradiol-17 beta (E2) were measured in the male lamb from 9 to 120 days of age, 24 h after castration. Concentrations of pituitary receptors did not change with age, but the total number of receptors and the pituitary weight showed a parallel increase (P less than 0.001). Conversely, there were no marked changes in the total number of hypothalamic receptors but this number was high as early as 9 days of age, 42.4 and 80.0 fmol/hypothalamus for DHT and E2, respectively. These data suggest that the number of hypothalamic and pituitary cytosol receptors to DHT and E2, is not a critical parameter in the succession of events which precedes puberty.
D000367:Age Factors; D000818:Animals; D002369:Castration; D003600:Cytosol / Q000378:metabolism*; D013196:Dihydrotestosterone / Q000378:metabolism*; D004958:Estradiol / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D010902:Pituitary Gland / Q000033:anatomy & histology*; D011987:Receptors, Steroid / Q000378:metabolism*; D012741:Sexual Maturation; D012756:Sheep; D013737:Testis / Q000033:anatomy & histology
D011987:Receptors, Steroid; D013196:Dihydrotestosterone; D004958:Estradiol