[Role of cell-surface protein screening and the determinant of the other sensitin in polyvalent sensitization of tannin-treated erythrocytes].
On the strength of the data obtained in the study of the successive loading of tannin-treated red cells with two protein antigens (with the use of 12 different models) the limiting role of two factors in comparison with monovalent sensitization has been revealed. When a red blood cell is previously loaded with one protein, the possibilities of binding the second protein decrease due to the reduction of the available cells surface. Besides, both these proteins bound to the red blood cell screen each other by creating steric obstacles to the interaction of the protein determinants with antibodies. Such steric obstacles suppress, to a lesser extent, the association of the bound proteins with antibodies and, to a greater extent, the agglutination of antibodies with sensitized red blood cells.
D000818:Animals; D000941:Antigens / Q000276:immunology*; D001667:Binding, Competitive; D001798:Blood Proteins / Q000276:immunology*; D004168:Diphtheria Toxoid / Q000276:immunology; D004912:Erythrocytes / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D007114:Immunization; D008297:Male; D008565:Membrane Proteins / Q000276:immunology*; D012756:Sheep / Q000276:immunology; D013499:Surface Properties; D013634:Tannins / Q000276:immunology*
D000941:Antigens; D001798:Blood Proteins; D004168:Diphtheria Toxoid; D008565:Membrane Proteins; D013634:Tannins; C012031:sensitin
Rol' ékranirovaniia belkami kletochnoĭ poverkhnosti i determinant drugogo sensitina v polivalentnoĭ sensibilizatsii tanizirovannykh éritrotsitov.