[Model of mediator secretion at a neuromuscular synapse based on the spatial heterogeneity of the probability of acetylcholine quantum release].
A spatial heterogeneity of the probability of the mediator quantum release (pt) along the nerve terminal was found in experiments on frog sartorius muscle with extracellular recording of end-plate potentials. The expression of Ca2+ ions effect depended upon the initial pt. With intracellular recording the increase of Ca2+ concentration from 0.2 to 1.8 mM was accompanied by increase of n and p binomial parameters. On the basis of the obtained data a model of mediator release at neuromuscular synapsis is proposed, which allows the estimation of the coefficients of pt distribution along the nerve terminal and the number of acting release sites. For estimation of these parameters it is necessary to calculate the n and p at two different Ca2+ ion concentrations.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D003201:Computers; D008433:Mathematics; D008564:Membrane Potentials; D008959:Models, Neurological; D009469:Neuromuscular Junction / Q000378:metabolism*; D011898:Ranidae
D000109:Acetylcholine; D002118:Calcium
Model' sekretsii mediatora v nervno-myshechnom sinapse, osnovannaia na prostranstvennoĭ neodonorodnosti veroiatnosti osvobozhdeniia kvanta atsetilkholina.