Elevated levels of phospholipase B in mice infected and challenged with Plasmodium yoelii.
Marked increases in phospholipase B activity were measured in spleen homogenates and sera of CD-1 mice given a primary infection of Plasmodium yoelii. The rise in enzyme activity paralleled parasitemia and splenomegaly, all reaching maximum values 14 days after infection. Maximum enzyme activity and splenomegaly were noted 5 days after challenge in mice given a secondary infection indicating an anamnesticlike response following a subsequent contact with the infecting parasite. These observations represent a new finding of this enzyme activity in a protozoan infection.
D000818:Animals; D005260:Female; D007109:Immunity; D008245:Lysophospholipase / Q000097:blood / Q000378:metabolism*; D008288:Malaria / Q000201:enzymology* / Q000276:immunology / Q000469:parasitology; D051379:Mice; D010740:Phospholipases / Q000378:metabolism*; D010961:Plasmodium / Q000276:immunology / Q000302:isolation & purification; D013154:Spleen / Q000201:enzymology
D010740:Phospholipases; D008245:Lysophospholipase