The effect of pinaverium bromide (LA 1717) on the lower oesophageal sphincter.
An acute, double-blind study was carried out in 8 healthy male volunteers to investigate any effect of a new antispasmodic, pinaverium bromide, compared with placebo on the lower oesophageal sphincter. Manometric measurements showed no significant differences in resting pressures either after placebo or a therapeutic dose (200 mg) of pinaverium bromide, suggesting that the active drug does not cause any impairment of function of the lower oesophageal sphincter.
D000328:Adult; D004311:Double-Blind Method; D004943:Esophagogastric Junction / Q000187:drug effects*; D006801:Humans; D008297:Male; D009025:Morpholines / Q000494:pharmacology*; D010276:Parasympatholytics
D009025:Morpholines; D010276:Parasympatholytics; C013199:pinaverium