[Dehydration therapy in human exposure to simulated space flight factors].
The effect of intravenous injections of 20% mannitol in a dose of 1 g per kg of body weight at a rate of 5 ml/min on the central circulation and cardiac contractile function was investigated. The infusions were performed to 18 healthy male volunteers, who participated in a head-down tilt test at -8 degrees, during the control period, on days 3, 7 and 14 of bed rest, and during the recovery. It was found that the prolonged osmo-therapy produced a clinically distinct dehydration effect without influencing central circulation. The therapy also led to positive cardiodynamics which was indicative of a decrease of the heart unproductive work and an improvement of left ventricle contractile function.
D000328:Adult; D001510:Bed Rest; D001929:Brain Edema / Q000503:physiopathology / Q000628:therapy; D003890:Desiccation / Q000379:methods*; D006439:Hemodynamics; D006801:Humans; D006982:Hypertonic Solutions; D008297:Male; D009200:Myocardial Contraction; D011187:Posture; D012171:Retinal Vessels / Q000503:physiopathology; D013026:Space Flight; D013997:Time Factors; D014893:Weightlessness / Q000009:adverse effects
D006982:Hypertonic Solutions
Degidratatsionnaia terapiia v usloviiakh vozdeĭstviia na organizm cheloveka modelirovannykh faktorov kosmicheskogo poleta.