Deciduoma formation in uterus of genetically mast cell-deficient W/Wv mice.
The role of mast cells in deciduoma formation in the uterus of mice was investigated by using genetically mast cell-deficient (WB x C57BL/6)F1-W/Wv (hereafter called WBB6F1-W/Wv) mice. Deciduoma formation occurred in castrated WBB6F1-W/Wv mice after estradiol-progesterone injection and traumatization in spite of their deficiency of mast cells. Injection of diphenhydramine, which blocks histamine receptors, inhibited deciduoma formation in WBB6F1-W/Wv mice as well as in congenic +/+ mice. THe uterus of WBB6F1-W/Wv mice contained about 10% of the amount of histamine found in the uterus of +/+ mice. These results suggest that mast cells are not essential for formation of deciduomata and that histamine originating from sources other than mast cells may be important in deciduoma formation.
D000818:Animals; D002369:Castration; D003656:Decidua / Q000473:pathology*; D004155:Diphenhydramine / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D008407:Mast Cells / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology; D014599:Uterus / Q000187:drug effects
D011374:Progesterone; D004958:Estradiol; D004155:Diphenhydramine