Effects of hypertension on cardiac performance in rats with myocardial infarction.
To determine the effects of hypertension and myocardial infarction on cardiac performance, hemodynamic studies were performed on ether-anesthetized, female spontaneously hypertensive rats and on two strains of normotensive rats, Wistar-Kyoto and American Wistar, 26 days after coronary arterial ligation. Baseline measurements of ventricular and arterial pressures and cardiac output (electromagnetic flowmeter) were obtained. Peak cardiac pumping and pressure-generating capacities were determined during a volume load and aortic occlusion, respectively. Infarct size was determined by planimetry. There was a progressive reduction in mean arterial pressure in relation to infarct size in both hypertensive and normotensive rats, but this reduction was twice as great in spontaneously hypertensive rats as in the normotensive rats, such that the arterial pressure of hypertensive rats with a moderate or large infarction decreased to within the "normotensive range." However, spontaneously hypertensive rats still maintained significantly higher arterial pressures than did normotensive rats at comparable infarct sizes. There was also a progressive reduction in the peak pressure developed during an afterload stress, and this reduction was greater in hypertensive rats than in normotensive rats with a large infarct. Maximal flow-generating capacity was similarly altered in rats with infarction: Peak stroke volume index varied inversely with infarct size and the reduction in this index was significantly greater in spontaneously hypertensive rats than in normotensive rats with a large infarct. Moreover, peak stroke work index was reduced to a greater extent in spontaneously hypertensive rats than in both normotensive strains of rats at any infarct size. Thus, after myocardial infarction, greater reductions in both pressure and flow-generating capacities occurred in hypertensive rats than in normotensive rats.
D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume; D001835:Body Weight; D003331:Coronary Vessels / Q000503:physiopathology; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006439:Hemodynamics; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology*; D009929:Organ Size; D010316:Particle Size; D051381:Rats; D011919:Rats, Inbred Strains; D013318:Stroke Volume