Is sickle cell trait a health hazard? Medical problems: a brief review.
Investigators have statistically linked the occurrence of certain conditions to sickle cell trait (hemoglobin AS). Other associations between hemoglobin AS and morbid conditions have been reported with reliable documentation, although these reports have lacked a statistical base. The need for continued, careful, and clear documentation of such associations is emphasized because physicians caring for patients with sickle cell trait will continue to question such associations. An approach to counseling patients with sickle cell trait is suggested.
D000755:Anemia, Sickle Cell / Q000150:complications*; D001437:Bacteriuria / Q000209:etiology; D003376:Counseling; D004913:Erythrocytes, Abnormal / Q000378:metabolism; D005260:Female; D005817:Genetic Counseling; D006417:Hematuria / Q000209:etiology; D006451:Hemoglobin, Sickle / Q000378:metabolism; D006801:Humans; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000209:etiology; D011655:Pulmonary Embolism / Q000209:etiology; D012306:Risk; D012805:Sickle Cell Trait / Q000150:complications*; D013159:Splenic Infarction / Q000209:etiology
D006451:Hemoglobin, Sickle