[Effect of enkephalin and cimetidine on the occurrence and course of duodenal ulcers in rats].
A study was made of the effect of a synthetic enkephalin analog and cimetidinee on experimental duodenal ulcer in rats induced by cysteamine administration. The ulcers were demonstrated to heal within 4 weeks. It was noted that ulcer occurrence was preceded by the increased serum gastrin level. Administration to rats of the enkephalin analog accelerated ulcer healing to a greater extent than that of cimetidin. It is suggested that one of the mechanisms of enkephalin analog protective action might involve the prevention of the gastrin increased level.
D000818:Animals; D002927:Cimetidine / Q000627:therapeutic use*; D003543:Cysteamine / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D004723:Endorphins / Q000627:therapeutic use*; D004745:Enkephalins / Q000627:therapeutic use*; D005755:Gastrins / Q000097:blood; D006146:Guanidines / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004723:Endorphins; D004745:Enkephalins; D005755:Gastrins; D006146:Guanidines; D003543:Cysteamine; D002927:Cimetidine
Vliianie énkefalina i tsimetidina na vozniknovenie i techenie duodenal'nykh iazv u krys.