Surgically induced acute hepatic failure in the rat.
Several surgical procedures were tested in the rat in order to create a spontaneously lethal but potentially reversible acute hepatic failure. Two combined surgical procedures fulfill these conditions: '75% hepatectomy' plus portacaval shunt and '85% hepatectomy' plus 30-min clamping of the celiac and superior mesenteric arteries. These two procedures should constitute useful tools for the evaluation of new methods of hepatic support.
D000818:Animals; D002445:Celiac Artery / Q000601:surgery; D004195:Disease Models, Animal; D006498:Hepatectomy; D008099:Liver / Q000601:surgery; D008107:Liver Diseases / Q000601:surgery*; D008297:Male; D008638:Mesenteric Arteries / Q000601:surgery; D011167:Portacaval Shunt, Surgical; D051381:Rats; D011919:Rats, Inbred Strains