Two cases of lymphoma of the parotid gland following ablative radioiodine therapy for thyroid carcinoma.
Two adult patients are described in whom 131I therapy thyroid carcinoma was followed by the development of non-Hodgkin's lymphoma in salivary glands. Histologically one was lymphocytic and the other histiocytic. The total doses of 131I given were 27 GBq (675 mCi) and 14GBq (350 mCi), lymphoma presenting 10 and 3 years respectively after the initial therapeutic dose of 131I. We suggest that the relationship is a causal one, because of the rarity of salivary gland lymphoma and the high dose or radiation to the salivary glands with this mode of therapy.
D000328:Adult; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects* / Q000627:therapeutic use; D008223:Lymphoma / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D010307:Parotid Neoplasms / Q000209:etiology*; D013964:Thyroid Neoplasms / Q000532:radiotherapy
D007457:Iodine Radioisotopes