Pharmacokinetics of amoxicillin and clavulanic acid administered alone and in combination.
The pharmacokinetics of amoxicillin and clavulanic acid, administered alone and in combination, were studied in six male and six female normal human volunteers. Each ingested 500 mg of amoxicillin or 125 mg of clavulanic acid or the above agents in combination in randomized sequences. The results indicate that most of the parameters tested for either substance are essentially independent of the presence of the other one.
D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage / Q000378:metabolism*; D002969:Clavulanic Acids / Q000008:administration & dosage / Q000378:metabolism*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male
D002969:Clavulanic Acids; D000658:Amoxicillin