Nonimmunological production of leukotrienes induced by platelet-activating factor.
Platelet-activating factor caused rapid pulmonary vasoconstriction and edema in isolated lungs perfused  with albumin-free salt solution devoid of formed blood elements. These effects may be due in part to the action of leukotrienes D4 and C4, which were identified by bioassay and high-pressure liquid chromatography in the lung effluent after stimulation by platelet-activating factor. These findings help illuminate some of the deleterious effects that platelet-activating factor elicits in anaphylactic reactions and possibly in other forms of lung injury.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D007213:Indomethacin / Q000494:pharmacology; D008168:Lung / Q000378:metabolism*; D008297:Male; D010972:Platelet Activating Factor / Q000494:pharmacology*; D051381:Rats; D013189:SRS-A / Q000096:biosynthesis* / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects
D010972:Platelet Activating Factor; D013189:SRS-A; D007213:Indomethacin