Binding of homologous versus heterologous low density lipoproteins by different tissues of the rat.
1. The ability of five different tissues of the rat to bind homologous and heterologous (human) low density lipoprotein (LDL) was compared. 2. Human LDL was as effective as rat LDL in displacing rat [125I]LDL from the plasma membrane fraction of rat skeletal muscle. 3. Membranes from rat liver appeared to have no affinity for homologous LDL, while human LDL was slightly more effective in displacing labeled rat LDL from this tissue. 4. A similar pattern of displacement was observed in membranes derived from rat heart. 5. In contrast, membranes from both the aorta and adrenal glands of the rat displayed a significantly greater affinity for binding LDL of homologous origin. 6. These results suggest that lipoprotein receptors analogous to those described for cultured human cells may exist in the rat and that individual tissues exhibit distinctly different affinities for binding LDL of both homologous and human origin.
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D066298:In Vitro Techniques; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008566:Membranes / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D011919:Rats, Inbred Strains
D008077:Lipoproteins, LDL