Cyclocreatine phosphate, an analogue of creatine phosphate, does not improve hypoxic tolerance in mice.
Dietary cyclocreatine has been reported to increase brain high-energy stores in mice and to prolong the generation and utilization of these stores following decapitation. A possible cerebral protective action after 50 days of dietary cyclocreatine 0.5 and 1.0% was therefore examined in mice. Cyclocreatine 0.5% did not increase survival time during hypoxia (5% O2). Cyclocreatine 1.0% in the absence of hypoxia caused significant mortality and decreased weight in survivors despite prophylactic antibiotic treatment. Dietary cyclocreatine offers no cerebral protection against hypoxia in mice.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D003655:Decerebrate State; D000860:Hypoxia / Q000378:metabolism*; D048289:Imidazolidines; D008297:Male; D010725:Phosphocreatine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D048289:Imidazolidines; D010725:Phosphocreatine; C012487:phosphocyclocreatine