Night-time indomethacin in rheumatoid arthritis.
Indomethacin is commonly prescribed at night to relieve morning stiffness in patients with rheumatoid arthritis. Pharmacokinetic and pharmacodynamic interactions are frequently described with non-steroidal anti-inflammatory drugs, and the rationale of using more than one of these agents at the same time is questionable. A randomized crossover trial was carried out in 14 patients to compare the effects of 100 mg indomethacin at night with those of placebo when added to a baseline regimen of stabilized salicylate therapy with a slow-release preparation. Each treatment was given for 2 weeks. The results suggest that the addition of indomethacin produced no significant benefit in terms of reduction in the duration of morning stiffness or on the overall daily pain score.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001241:Aspirin / Q000008:administration & dosage; D003692:Delayed-Action Preparations; D004359:Drug Therapy, Combination; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D008875:Middle Aged
D003692:Delayed-Action Preparations; D001241:Aspirin; D007213:Indomethacin