Antispermatogenic/antiandrogenic properties of solasodine (C27H43O2N) obtained from solanum xanthocarpum berries on the male genital tract of dog (Canis-familiaris). A histophysiological approach.
Chronic administration of solasodine (20 mg/kg alt. day for 30 days) caused testicular lesions resulting in a severe impairment of spermatogenic elements. The epididymides were devoid of spermatozoa. Total protein, sialic acid and glycogen contents of the testis and epididymis were reduced significantly whereas the testicular cholesterol was elevated. Acid Phosphatase enzyme activity of the testes was low after solasodine treatment. Serum enzymes (SGPT, alkaline phosphatase) serum protein, triglycerides, non esterified fatty acid levels were in normal range when compared with their own controls. Cholesterol and phospholipid levels were elevated after solasodine treatment to intact dogs. Reduced androgen production was reflected in low levels of sialic acid in the testes and epididymides and reduced Leydig cell nuclei. Castration alone brought about reduction in size of the epididymis. Castration followed by solasodine treatment caused epididymal degeneration. Simultaneous administration of TP to solasodine treated castrated dogs failed to stimulate the epididymal growth. Antispermatogenic/antiandrogenic activity of the compound solasodine is discussed. Solasodine administration in dogs definitely rendered the male infertile as evidenced by the absence of sperms in the cauda epididymis and ductus deferens.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002369:Castration; D004285:Dogs; D004822:Epididymis / Q000473:pathology; D007985:Leydig Cells / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D012671:Seminiferous Tubules / Q000473:pathology; D012991:Solanaceous Alkaloids / Q000494:pharmacology*; D013737:Testis / Q000473:pathology*; D013739:Testosterone / Q000494:pharmacology; D014649:Vas Deferens / Q000473:pathology
D012991:Solanaceous Alkaloids; D013739:Testosterone; C012037:solasodine