Human leukocyte interferon does not induce sister-chromatid exchanges in human blood lymphocytes.
The effect of human leukocyte interferon on sister-chromatid exchanges (SCE) and chromosomal aberratins was studied in the peripheral blood lymphocytes of 4 healthy male donors. No significant differences were found in the incidence of SCE and aberrations. Also the response to PHA stimulation and the rate of cell multiplication was not altered when the lymphocytes are exposed to human leukocyte interferon.
D002869:Chromosome Aberrations; D003434:Crossing Over, Genetic / Q000187:drug effects*; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008937:Mitomycins / Q000494:pharmacology; D008938:Mitosis / Q000187:drug effects; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D007370:Interferon Type I; D008937:Mitomycins