Linkage of the structural gene for uroporphyrinogen I synthase to markers on mouse chromosome 9 in a cross between feral and inbred mice.
The Ups locus has been mapped to mouse chromosome 9 in a three-point cross. The observed gene order is centromere-Ups-15-Mpi-1-22-Mod-1. Ups is unlinked to Lv, which encodes the previous enzyme in the heme biosynthesis pathway. Feral mice collected at Skive, Denmark, have been characterized at several biochemical loci; multiple differences from inbred strains make this a useful stock for linkage analysis.
D000483:Alleles; D000642:Ammonia-Lyases / Q000235:genetics*; D000818:Animals; D001797:Blood Protein Electrophoresis; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D011163:Hydroxymethylbilane Synthase / Q000235:genetics*; D008297:Male; D051379:Mice / Q000235:genetics*; D008810:Mice, Inbred C57BL / Q000235:genetics
D011163:Hydroxymethylbilane Synthase; D000642:Ammonia-Lyases