[Glutamate decarboxylase activity in subcellular fractions of tissue of brain visual analyzer of dogs subjected to visual deprivation].
Glutamate decarboxylase activity in fractions of mitochondria, synaptosomes and membranes fragments of tissues brain visual analyzer central structures of the dog was found to decrease during visual deprivation. A degree of the decrease is different and depends on the deprivation duration. During a 45-day deprivation the specific activity of the enzyme lowers significantly in all subfractions, decrease is especially sharp in subfractions of heavy synaptosome and membranes (by 71-85%). The decrease in the activity is more pronounced in the anterior corpora bigemina and in external geniculate body than in the cortex visual area (field 17). During a 90-day deprivation the activity lowers in all the structures but to a less extent than during the 45-day deprivation. The specific activity in subfractions of heavy and light synaptosomes is 40-67% lower than normal and in the membrane and mitochondrial subfractions differs slightly. In the visual deprived dogs the intensity of GABA formation reduces in all the subfractions, the decrease being higher during the 45-day deprivation.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002262:Carboxy-Lyases / Q000378:metabolism*; D004285:Dogs; D005829:Geniculate Bodies / Q000201:enzymology; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D008928:Mitochondria / Q000201:enzymology*; D009928:Organ Specificity; D012683:Sensory Deprivation; D013347:Subcellular Fractions / Q000201:enzymology; D013574:Synaptosomes / Q000201:enzymology*; D014793:Visual Cortex / Q000201:enzymology; D014796:Visual Perception
D002262:Carboxy-Lyases; D005968:Glutamate Decarboxylase
Aktivnost' glutamatdekarboksilazy v subkletochnykh fraktsiiakh tkaneĭ ritel'nogo analizatora mozga sobak pri zritel'noi depreivatsii.