Corticosteroid therapy in case of immunologic infertility--a preliminary report.
Six couples with immunologic infertility were treated with corticosteroids. In five patients prednisone 5 mg three times daily were used and in one patient methylprednisolone 96 mg daily for seven days. The duration of therapy varied from two to eleven months before any positive results occurred. In five patients the serum antibody titre declined significantly and three pregnancies resulted. In the two cases where the serum antibody titre declined, but the SCMC test did not improve, pregnancy did not result. The follow-up SCMC test after completion of therapy may have more prognostic value than the serum sperm antibody estimations.
D000906:Antibodies / Q000032:analysis; D002582:Cervix Mucus / Q000502:physiology; D005260:Female; D006801:Humans; D007246:Infertility / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use*; D013094:Spermatozoa / Q000276:immunology* / Q000502:physiology
D000906:Antibodies; D011241:Prednisone; D008775:Methylprednisolone