Testing for drugs inhibiting the formation of gastric ulcers.
Copper salicylate has been shown to be an inhibitor of gastric lesions in rats induced by aspirin, indomethacin and cold stress whereas cimetidine was only effective against those produced by cold stress. The results are in line with those reported earlier for the anti-ulcer activity of sodium salicylate and metiamide respectively. On this basis, it appears that the animal model of stress-induced gastric lesions in the rat is the most suitable for testing the activity of new-antiulcer drugs.
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001241:Aspirin; D002927:Cimetidine / Q000494:pharmacology; D003080:Cold Temperature; D003300:Copper / Q000494:pharmacology; D007213:Indomethacin; D009093:Mucus / Q000502:physiology; D009942:Organometallic Compounds; D051381:Rats; D011919:Rats, Inbred Strains; D011970:Receptors, Histamine H2 / Q000502:physiology; D012459:Salicylates / Q000494:pharmacology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control; D013312:Stress, Physiological / Q000503:physiopathology
D000897:Anti-Ulcer Agents; D009942:Organometallic Compounds; D011970:Receptors, Histamine H2; D012459:Salicylates; C025564:copper salicylate complex; D003300:Copper; D002927:Cimetidine; D001241:Aspirin; D007213:Indomethacin