Cutaneous penetration of some hairdyes in the hairless rat.
The cutaneous penetration of certain number of oxidation dyestuffs for hair [p-aminophenol, 2,4-diaminoanisole, 2,4-diaminophenoxyethanol, resorcinol, 3-acetylamino-2,6-dimethylphenol and the indamine: N-(4'-hydroxyphenyl)-3-amino-6-methylbenzoquinoneimine], either alone or when formulated with other dyestuffs, and under various experimental conditions, has been evaluated in the hairless rat using C14 labeled molecules. It has been found that: Dyestuffs having indamine structures, formed by oxidation of their precursors (bases, couplers), for all practical purposes do not cross the cutaneous barrier. No fixation of those dyestuffs investigated (resorcinol, 2,4-diaminoanisole, 2,4-diaminophenoxyethanol) which do pass through the cutaneous barrier is found in either liver or thyroid of the experimental animals, 4 days after their topical application. The amount of the hairdye 3-acetylamino-2,6-dimethylphenol which penetrates the cutaneous barrier is constant for quantities of hairdye solution greater than or equal to 20 mg/cm2 of skin. The type and composition of the excipient used in the formulation of hairdyes plays an important role in their penetration.
D000627:Aminophenols / Q000378:metabolism; D000818:Animals; D003959:Diamines / Q000378:metabolism; D005260:Female; D006202:Hair Dyes / Q000378:metabolism*; D006203:Hair Preparations / Q000378:metabolism*; D007215:Indophenol / Q000031:analogs & derivatives / Q000378:metabolism; D010655:Phenylenediamines / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012118:Resorcinols / Q000378:metabolism; D012869:Skin Absorption; D014992:Xylenes / Q000378:metabolism
D000627:Aminophenols; D003959:Diamines; D006202:Hair Dyes; D006203:Hair Preparations; D010655:Phenylenediamines; D012118:Resorcinols; D014992:Xylenes; C036170:3-acetylamino-2,6-dimethylphenol; C036169:(4'-hydroxyphenyl)-3-amino-6-methylbenzoquinoneimine; D007215:Indophenol; C007294:4-methoxy-3-phenylenediamine; C032556:2-(2',4'-diaminophenoxy)ethanol; C026729:4-aminophenol; C031389:resorcinol