Altered peroxide metabolism in erythrocytes from children with cystic fibrosis.
The superoxide dismutase and catalase activities and the lipid peroxidation values in the blood of healthy volunteers were compared with those of children of various ages and of both sexes with cystic fibrosis and with those of the heterozygous parents of these children. The red blood cell superoxide dismutase and catalase activities in children with cystic fibrosis and in their parents are significantly increased. At the same time, the lipid peroxidation of the red blood cells (the quantity of thiobarbituric acid reactive substance) is significantly reduced.
D000328:Adult; D002374:Catalase / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000097:blood* / Q000201:enzymology; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D010545:Peroxides / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood
D008054:Lipid Peroxides; D010545:Peroxides; D002374:Catalase; D013482:Superoxide Dismutase