High-density lipoproteins and hepatic microsomal enzyme induction in alcohol consumers.
Plasma HDL cholesterol (HDL-C) and major apolipoproteins, A-I (A-I) and A-II (A-II), and indices of hepatic microsomal function, liver cytochrome P-450 (P-450) and plasma antipyrine clearance rate (AP-CL), in eight alcohol consumers and eight non-drinkers were compared. Alcohol consumers had increased P-450 and AP-CL showing an induction of hepatic microsomal function, and elevated HDL-C, A-I and A-II as compared with values in non-drinkers. Liver cytochrome P-450 concentrations were directly proportional to plasma HDL-C (r = 0.732, p less than 0.01) and A-I (r = 0.564, p less than 0.05) levels. These data suggest that alcohol by inducing liver microsomal function increases plasma HDL and thus favorably alters one of the risk factors of coronary heart disease.
D000428:Alcohol Drinking; D001053:Apolipoproteins / Q000097:blood; D001054:Apolipoproteins A; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008862:Microsomes, Liver / Q000201:enzymology*
D001053:Apolipoproteins; D001054:Apolipoproteins A; D008075:Lipoproteins, HDL; D003577:Cytochrome P-450 Enzyme System