[In vivo formation from rat milk proteins of a peptide inhibitor of gastric secretion].
A peptide fraction was isolated from the gastric content of 10-day-old suckling rats by Sephadex G-25 and G-10 chromatography. Intravenous injection of peptide (15 mg) had a powerful inhibitory action on gastric secretion of dogs with Pavlov pouches. It is assumed that this fraction is formed from rat casein and inhibits gastric secretion in the newborn, reducing rat milk proteolysis.
D000818:Animals; D000833:Animals, Suckling; D004285:Dogs; D005260:Female; D005749:Gastric Inhibitory Polypeptide / Q000096:biosynthesis* / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000096:biosynthesis*; D008894:Milk Proteins / Q000378:metabolism*; D051381:Rats
D005768:Gastrointestinal Hormones; D008894:Milk Proteins; D005749:Gastric Inhibitory Polypeptide
Obrazovanie in vivo iz belkov krysinogo moloka peptida--ingibitora zheludochnoĭ sekretsii.