UV-induced chromosome aberrations, sister-chromatid exchanges and cell survival in cultured lymphocytes from malnourished children.
Cultured lymphocytes from children with kwashiorkor and from normal children were examined for their susceptibility to ultraviolet (UV)-induced chromosome aberrations, sister-chromatid exchanges and cell survival. Cells from kwashiorkor exhibited increased chromosome aberrations, but not sister-chromatid exchanges, when exposed to higher doses of UV. Furthermore, when cells from these patients were exposed to higher doses of UV, there was a significant reduction in viability. These results indicate that, as compared to normals, cells from kwashiorkor were more sensitive to the lethal effects of UV.
D002470:Cell Survival / Q000528:radiation effects; D002478:Cells, Cultured; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects; D003434:Crossing Over, Genetic; D005260:Female; D006801:Humans; D007223:Infant; D007732:Kwashiorkor / Q000235:genetics*; D008214:Lymphocytes / Q000528:radiation effects; D008297:Male; D011829:Radiation Dosage; D012854:Sister Chromatid Exchange; D014466:Ultraviolet Rays / Q000009:adverse effects*