Anthracyclic products from Streptomyces erythromogenes nov. sp. Biotransformation of daunomycin (Dn) by an acellular preparation and synergism between Dn and some known antibiotics.
The filtrate broth as well as mycelium of the new strain Streptomyces erythrochromogenes nov. sp. isolated from Saudi Arabian soil, produce the antitumor antibiotic daunomycin 1 and two anthracyclic derivatives: 7-deoxy 13-dihydrodaunomycinone 2 and 7-deoxy daunomycinone 4. The biotransformation of 1 to 2 and 4 by an acellular enzyme preparation from the strain was found to be NADPH and/or NADH dependent. Mixtures of daunomycin 1 with chloramphenicol or penicillin showed superior antimicrobial activities against Bacillus subtilis ICC strain, than the individual antibiotics.
D001407:Bacillus / Q000187:drug effects; D001711:Biotransformation; D002701:Chloramphenicol / Q000494:pharmacology; D003630:Daunorubicin / Q000378:metabolism* / Q000494:pharmacology / Q000031:analogs & derivatives; D004357:Drug Synergism; D009243:NAD / Q000378:metabolism; D009279:Naphthacenes / Q000378:metabolism*; D010400:Penicillin G / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*; D013752:Tetracycline / Q000494:pharmacology
D009279:Naphthacenes; D009243:NAD; C035451:7-deoxy-13-dihydrodaunorubicinone; C035452:7-deoxydaunomycinone; D002701:Chloramphenicol; D013752:Tetracycline; D010400:Penicillin G; D003630:Daunorubicin