Iopamidol: a non-ionic contrast agent for peripheral arteriography.
Ten patients undergoing peripheral arteriography with iopamidol were evaluated in a carefully controlled Phase I study using a variety of objective and subjective tests of discomfort. There was minimal objective evidence of pain, and the patients reported that they perceived minor discomfort and a warm sensation during the contrast injections. Five patients who had previously undergone arteriography using 2 mg of lidocaine per ml of methylglucamine diatrizoate noted a marked decrease in discomfort when iopamidol was used. Opacification of peripheral arteries was excellent. Multiple physical examinations, chemical tests, electrocardiograms, and intra-arterial pressure recordings showed that iopamidol is safe.
D000328:Adult; D000368:Aged; D000792:Angiography / Q000009:adverse effects / Q000379:methods*; D001794:Blood Pressure; D003287:Contrast Media / Q000009:adverse effects; D004341:Drug Evaluation; D006801:Humans; D007479:Iopamidol; D007483:Iothalamic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged
D003287:Contrast Media; D007483:Iothalamic Acid; D007479:Iopamidol