Pharmacokinetics of 14C-DMPS (sodium-1,3 14C-2,3-dimercaptopropane-1-sulphonate) in beagle dogs.
The pharmacokinetics of labelled DMPS (sodium-1,3 14C-2,3-dimercaptopropane-1-sulphonate) have been studied in four beagle dogs following bolus intravenous injection (65.7 mumol kg-1) and oral administration (197 mumol kg-1). Following intravenous injection the main kinetic parameters were t 1/2 = 43 min, V beta = 160 ml kg-1, and plasma clearance Clp = 2.6 ml min-1 kg-1. Following oral administration 14C-DMPS is rapidly absorbed with peak concentrations (478 +/- 25 mumol l-1) measured after 30-45 min. About 60 per cent of the oral dose was absorbed. Estimates of t 1/2, V beta, and Clp after oral administration were in close agreement with the values obtained in the intravenous study. 14C-DMPS is eliminated from the body by the kidneys. About 70 per cent of 14C-DMPS in dog plasma are bound to proteins. Binding is even higher in plasma from rat and man.
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D001798:Blood Proteins / Q000378:metabolism; D004112:Dimercaprol / Q000031:analogs & derivatives*; D004285:Dogs; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D011485:Protein Binding; D014494:Unithiol / Q000378:metabolism*
D001798:Blood Proteins; D004112:Dimercaprol; D014494:Unithiol