The effects of 2,5-hexane dione on remyelination in the peripheral nervous system of the mouse.
We compared the development and resolution of a demyelinating lesion (produced by the intraneural injection of lysophosphatidyl choline) in mice exposed to a known neurotoxic agent (2,5-hexane dione) with similar events in control animals. A prolongation of the pro-myelin stage was observed in the hexane dione-treated animals: the suppression of remyelination became progressively more marked with the length of exposure to hexane dione. Prolongation of the pro-myelin stage is an indication of a disturbance in some component of the complex interaction between Schwann cell and axon, and presumably reflects the neurotoxicity of 2,5-hexane dione.
D000818:Animals; D003711:Demyelinating Diseases / Q000139:chemically induced / Q000503:physiopathology; D005260:Female; D006588:Hexanones / Q000494:pharmacology*; D007659:Ketones / Q000494:pharmacology*; D008244:Lysophosphatidylcholines; D051379:Mice; D008815:Mice, Inbred Strains; D009186:Myelin Sheath / Q000187:drug effects* / Q000503:physiopathology; D009416:Nerve Regeneration; D012584:Sciatic Nerve / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D006588:Hexanones; D007659:Ketones; D008244:Lysophosphatidylcholines; D014316:Tritium; C011269:2,5-hexanedione; D013936:Thymidine