The response of kidney to ionizing radiation combined with hyperthermia induced by ultrasound.
Mouse kidneys were made hyperthermic (42.5 degrees C for 30 min) one hour before, during, or one hour after local irradiation to determine the effect of hyperthermia on radiation damage. An ultrasound beam was used to induce hyperthermia. The urinary concentrations of total protein and albumin were used as criteria of kidney injury. Hyperthermia alone did not induce proteinuria. Radiation alone produced proteinuria that was not correlated with dose. Hyperthermia induced during or after irradiation resulted in a thermal enhancement factor of 1.29 +/- .33. Hyperthermia induced one hour before irradiation resulted in a thermal enhancement factor of 0.88 +/- .05, indicating a radioprotective effect. To the authors' knowledge, this is the first time such an effect has been shown.
D000419:Albuminuria / Q000209:etiology; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006358:Hot Temperature; D007668:Kidney / Q000528:radiation effects*; D051379:Mice; D008809:Mice, Inbred C3H; D011507:Proteinuria / Q000209:etiology; D011833:Radiation Injuries, Experimental; D011835:Radiation Protection; D013997:Time Factors; D014465:Ultrasonics