[Relation between the density and maturity of red blood cells in the perinatal period in the rat].
Relations between 59Fe incorporation into red blood cells (rbc) and their density was examined in rats during ontogenesis (20th, 21st, 22nd gestational day, 1st, 21st day of life, adults). The incorporation of 59Fe in rbc of different density was measured 24 or 96 h after application. The density separation was carried out by centrifugation of rbc in phthalate esters of known density. The density of rbc increased during ontogenesis (median density 1.093 kg/l on the 20th gestational day and 1.102 kg/l in adult rats). The erythropoietic activity, in terms of 59Fe-incorporation into peripheral rbc, is higher in newborn rats (60-70%) than in adults (30-50%). 59Fe incorporation into pregnant rats and their fetuses is similar to adult nonpregnant rats. In fetuses a relatively high incorporation of 59Fe was found in comparison to their mother. The relationship between density and maturity of rbc is postnatally more evident than in the prenatal period. (59Fe enrichment in cells of low density prenatally: 2.6 +/- 0.5, postnatally: 8.4 +/- 0.5 (1st day of life), 5.8 +/- 0.8 (21st day of life) 28.5 +/- 5.6 (adult male rats). These findings may reflect a simultaneous formation of rbc at different sites or different clonal origin during prenatal period of ontogenesis.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001799:Blood Sedimentation; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D008297:Male; D011247:Pregnancy; D051381:Rats
D007501:Iron
Beziehungen zwischen Dichte und Jugendlichkeit von roten Blutzellen in der Perinatalperiode der Ratte.