A new genetic variation of the malate dehydrogenase-like enzyme (MDL-1) in inbred rats and its possible linkage.
A new polymorphism in the mitochondrial fraction of kidney homogenates was found by using discontinuous polyacrylamide gel electrophoresis. The polymorphism is tentatively designated MDL-1, since the enzyme was visualized with the staining solution for NADP-malate dehydrogenase (MOD) but differs from MOD. MDL-1 expresses three phenotypes: MDL-1A (fast), MDL-1AB (intermediate), and MDL-1B (slow). Progeny testing from genetic crosses indicates that its expression is determined by two codominant alleles, Mdl-1a and Mdl-1b, which segregate in a simple Mendelian fashion. Preliminary linkage data suggest that the locus for MDL-1 is probably linked to the nonagouti-agouti locus in rat linkage group IV.
D000483:Alleles; D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D014644:Genetic Variation; D005838:Genotype; D007668:Kidney / Q000201:enzymology*; D008291:Malate Dehydrogenase / Q000235:genetics*; D008297:Male; D008928:Mitochondria / Q000201:enzymology*; D011110:Polymorphism, Genetic; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D008291:Malate Dehydrogenase