Cerebrovascular permeability and cerebral blood flow in hypertension induced by gammahydroxybutyric acid. An experimental study in the rat.
A sustained increase in blood pressure was obtained by intraperitoneal (i.p.) or intravenous (i.v.) administration of gammahydroxybutyric acid (GHBA, 1 g/kg) in rats under nitrous oxide anesthesia and in conscious rats with indwelling catheters in the aorta and a jugular vein. Evans blue-albumin and 125I-labeled serum albumin, given i.v. before GHBA, were used to study the function of the blood-barrier in rats killed 60 min after the injection of the drug. Brains from rats subjected to acute hypertension while awake showed less extravasation of albumin than did brains from anesthetized rats. Sectioning of the cervical symphatetic nerves did not increase extravasation in conscious rats. The cerebral blood flow, determined with the 14C-ethanol technique, did not significantly differ in GHBA-treated rats and controls. Because of the sustained increase in blood pressure, GHBA-induced hypertension might be a useful model for the study of long-term effects on the brain of hypertensive opening of the blood-brain barrier.
D000768:Anesthesia, General; D000818:Animals; D001794:Blood Pressure; D002199:Capillary Permeability; D002560:Cerebrovascular Circulation; D003243:Consciousness; D006885:Hydroxybutyrates; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012978:Sodium Oxybate
D006885:Hydroxybutyrates; D012978:Sodium Oxybate