[Acute nadoxolol poisoning. A multicentric study of 35 cases].
Between 1976 and 1980, 35 cases of nadoxolol poisoning were collected from french antipoison centers. Acute intoxication was voluntary (50%) or accidental (50%). The ingested dose ranged between 0,25 and 22,5 g. Clinical symptoms appeared three hours after ingestion and consisted of cardio-vascular disorders which were present in 10 patients: bradycardia (7 cases), cardiogenic shock (6 cases), intraventricular block (5 cases), increase of P.R. interval (4 cases) and Q.T. interval (3 cases). The toxic dose in otherwise healthy adults was 5 g. The treatment consisted of gastric lavage and correction of cardiovascular disorders with sodium lactate (4 cases) or dopamine (1 case). All the patients recovered.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000139:chemically induced; D002675:Child, Preschool; D004298:Dopamine / Q000627:therapeutic use; D004562:Electrocardiography; D006801:Humans; D007223:Infant; D007773:Lactates / Q000627:therapeutic use; D019344:Lactic Acid; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced; D010091:Oximes / Q000506:poisoning*; D007507:Therapeutic Irrigation
D007773:Lactates; D010091:Oximes; D019344:Lactic Acid; C006154:nadoxolol; D004298:Dopamine
Les intoxications aiguës par le nadoxolol. Etude multicentrique de 35 observations.