Manometric assessment of oesophageal involvement in progressive systemic sclerosis, morphoea and Raynaud's disease.
Oesophageal function was studied by radiography and manometry in fifty-one patients with progressive system sclerosis (PSS), fourteen patients with morphoea, twelve patients with Raynaud's disease and twenty-one normal subjects. Upper oesophageal sphincter pressure was not affected. Peristaltic contractions of the upper third of the oesophagus were significantly decreased in PSS and morphoea, but the lower two-thirds were affected only in PSS. Lower oesophageal sphincter pressure was significantly decreased in PSS but was normal in morphoea and Raynaud's disease. There was a significant correlation between oesophageal dysfunction and the duration of PSS. Manometry was better than radiography at detecting motor abnormalities, with a positivity of 86% compared with 66% for radiography. Oesophageal manometry should be employed routinely in the investigation of patients with suspected PSS or morphoea.
D000293:Adolescent; D000328:Adult; D000368:Aged; D004947:Esophagus / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011312:Pressure; D011859:Radiography; D011928:Raynaud Disease / Q000503:physiopathology*; D012594:Scleroderma, Localized / Q000503:physiopathology*; D012595:Scleroderma, Systemic / Q000503:physiopathology*; D012871:Skin Diseases / Q000209:etiology; D013997:Time Factors