Lipid abnormalities in chronic renal failure associated with spinal cord injury.
Serum lipid fractions were studied in ten patients with chronic renal failure (CRF) associated with long-standing spinal cord injury (SCI). A group of age-and-sex-matched patients with long-standing SCI but normal renal function were included for comparison. Serum triglycerides were markedly elevated in SCI-CRF patients. Both SCI groups exhibited moderate hypocholesterolemia. High density lipoprotein (HDL) cholesterol was severely reduced in the SCI-CRF group and moderately reduced in the SCI-control group. Chronic renal failure, reduced physical activity and several other factors may be operative in the genesis of hypertriglyceridemia and reduced HDL-cholesterol levels in this condition. Further investigations are necessary to examine the possible effect of these lipid abnormalities on the cardiovascular system in these patients.
D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D013119:Spinal Cord Injuries / Q000150:complications*; D014280:Triglycerides / Q000097:blood*
D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D014280:Triglycerides; D002784:Cholesterol