The effect of leukotriene C4 and D4 on cutaneous blood flow in humans.
Using a laser-Doppler-flowmeter the microvascular response to LTC4 and LTD4 was measured. Intradermal injection of 1 microgram LTC4 and LTD4 caused an increase in the microvascular cutaneous bloodflow. The increase in flow was equal to that caused by histamine in equimolar amounts. Blocking the triple-response did not change the response. The values measured after injection of histamine and leucotrienes were about 10-15 times the values found in undisturbed skin and represents probably a maximally dilated vascular bed. Injection of the leucotrienes caused a slight sensation of pain.
D000328:Adult; D006801:Humans; D007271:Injections, Intradermal; D007834:Lasers; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D012039:Regional Blood Flow / Q000187:drug effects; D013189:SRS-A / Q000008:administration & dosage / Q000494:pharmacology*; D012867:Skin / Q000098:blood supply*
D013189:SRS-A