[Effect of alcohol consumption for a year on isovolumetric and auxotonic parameters in the rat heart].
Ethanol (20%) was given to wistar rats for 12 months, water to controls. In the intact heart in-situ parameters of pressure, volume, blood flow and contractility were recorded under control conditions as well as after dopamine given intravenously. Body weight of the ethanol-treated rats was diminished by 12.2%, heart weight by 12.7%, as compared with controls. A significant difference between controls and ethanol-treated rats was only found for isovolumetric left ventricular pressure. The increase in heart rate due to dopamine is less in the ethanol-treated rats. In all other parameters, no significant differences between both groups were observed.
D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002310:Cardiomyopathy, Alcoholic / Q000209:etiology* / Q000503:physiopathology*; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology; D000431:Ethanol; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol; D004298:Dopamine
Der Einfluss einer einjährigen Alkoholfütterung auf isovolumetrische und auxotonische Parameter des Rattenherzens.