Pharmacological properties and monoaminergic mediation of the slow IPSP, in mammalian sympathetic ganglion.
Phenoxybenzamine can selectively eliminate the s-IPSP, in the presence of anti-cholinesterases that enhance s-IPSP and s-EPSP; and the alpha 2-antagonist, yohimbine, can partially but consistently depress s-IPSP selectively. The results provide positive pharmacological support for the monoaminergic nature of the transmitter for s-IPSP in mammalian sympathetic ganglia and argue against suggestions that the s-IPSP is a direct hyperpolarizing response to acetylcholine.
D000818:Animals; D004553:Electric Conductivity; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000502:physiology*; D010643:Phenoxybenzamine / Q000494:pharmacology*; D011817:Rabbits; D014403:Tubocurarine / Q000494:pharmacology; D015016:Yohimbine / Q000494:pharmacology
D010643:Phenoxybenzamine; D015016:Yohimbine; D014403:Tubocurarine