Triethyl lead toxicity in relation to brain glutathione and glutathione S-transferase.
A dose-dependent decrease in the content of reduced glutathione (GSH) was found in the brain of rats following treatment with Pb(Et)3 for varying time intervals. Maximum inhibition of 19% was observed 3 h after the last dose of Pb(Et)3 (8 mg/kg) daily for 3 days. Glutathione S-transferase activity did not change significantly. In vitro, there was no conjugation of GSH with PbEt3 and the addition of brain cytosol did not catalyse the conjugation.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D007854:Lead / Q000633:toxicity*; D009942:Organometallic Compounds / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D009942:Organometallic Compounds; D007854:Lead; C010360:triethyllead; D005982:Glutathione Transferase; D005978:Glutathione