Ontogenesis of glucose sensitivity in the rat lateral hypothalamus: a brain slice study.
The development of glucose-sensitive neurons in the lateral hypothalamus (LHA) brain slices was examined. In 60-100-day-old rats, 20% of LHA neurons were sensitive, that is, their firing rates decreased upon increase in the glucose concentration in the perfusate and increased upon decrease in glucose concentration. In 2-, 3- and 7-day-old rats, 16% of the neurons were glucose sensitive. Results confirm glucose-sensitivity in the LHA at a very early stage of ontogeny.
D000818:Animals; D000831:Animals, Newborn; D001786:Blood Glucose / Q000378:metabolism*; D002454:Cell Differentiation; D002628:Chemoreceptor Cells / Q000166:cytology*; D046508:Culture Techniques; D005071:Evoked Potentials; D005260:Female; D007026:Hypothalamic Area, Lateral / Q000166:cytology*; D008297:Male; D009474:Neurons / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose