Testicular relapse in acute childhood leukemia.
The successful induction and maintenance of hematologic remission in childhood acute leukemia has led to the recognition of extramedullary leukemia as a major clinical problem [1-6]. The central nervous system is the most common site of extramedullary relapse [1,7-12]. A more recently recognized form of extramedullary relapse is the testis [13-22]. This paper will review a series of patients with childhood acute leukemia who suffered testicular relapse. Modes of therapy for testicular relapse and research conducted into the etiology of testicular relapse will be discussed.
D000208:Acute Disease; D000293:Adolescent; D002369:Castration; D002648:Child; D005260:Female; D006801:Humans; D007938:Leukemia; D008297:Male; D011879:Radiotherapy Dosage; D012306:Risk; D013736:Testicular Neoplasms / Q000209:etiology / Q000628:therapy*