[Comparative crossover double-blind study of profenid and indomethacin patients with rheumatoid arthritis].
38 patients with active rheumatoid arthritis, randomly divided into two groups, underwent a three weeks treatment with profenid (3 capsules + 1 suppositorium) alternatively with indomethacin (3 capsules + 1 suppositorium), which head lasted six weeks in case of each patient. The study was double-blind using a crossover technique. The results show that the efficacy of the applied doses of profenid is similar to that of indomethacin. Profenid is superior to indomethacin with regard to drug tolerance.
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000627:therapeutic use*; D007660:Ketoprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010666:Phenylpropionates / Q000627:therapeutic use*; D011897:Random Allocation
D010666:Phenylpropionates; D007660:Ketoprofen; D007213:Indomethacin
Vergleichende Crossover-Doppelblindstudie mit Profenid und Indometazin bei Patienten mit Rheumatoid-Arthritis.