Phencyclidine raises kindled seizure thresholds.
Phencyclidine (PCP) has been reported to have both anesthetic and seizure-inducing properties. In the present experiment the effect of PCP on previously established seizures, kindled in the amygdala, was examined, using rats as subjects. In a repeated measures design three doses of PCP (1, 2 and 5 mg/kg) were compared with a saline control condition. The high dose of PCP was found to significantly increase seizural afterdischarge thresholds, while not affecting seizure durations.
D000679:Amygdala / Q000187:drug effects; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007696:Kindling, Neurologic / Q000187:drug effects*; D009115:Muridae; D010622:Phencyclidine / Q000494:pharmacology*; D012640:Seizures / Q000139:chemically induced*; D012684:Sensory Thresholds
D010622:Phencyclidine