Identification of metabolites of 9-beta-D-arabinofuranosyl-2-fluoroadenine, an antitumor and antiviral agent.
Analysis of blood from a dog given a 400 mg/m2 dose of 9-beta-D-arabinofuranosyl-2-fluoroadenine (2-F-araA) led to the identification of parent drug and a major metabolite, 9-beta-D-arabinofuranosyl-2-fluorohypoxanthine. 2-Fluoroadenine, a toxic derivative of 2-F-araA, was not detected in blood within the limits of detection, suggesting that parent drug was absorbed and distributed without systemic exposure to this toxic derivative. Parent drug, 2-fluoroadenine, and 9-beta-D-arabinofuranosyl-2-fluorohypoxanthine were identified in urine of dog, monkey, and mouse.
D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism*; D000998:Antiviral Agents / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D005260:Female; D007939:Leukemia L1210 / Q000188:drug therapy; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D014740:Vidarabine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D014740:Vidarabine; C024352:fludarabine