[The quantities of main urinary metabolite of PGF, plasma PGF and plasma PGE in pulmonary diseases].
Radioimmunoassays of urinary 5 alpha-7 alpha-dihydroxyketotetranorprosta-1,16-dioic acid and its delta-lactone(main urinary metabolite of PGF, PGF-MUM) were performed for the patients with several pulmonary diseases. The quantities of PGE and PGF in plasma for the patients with pulmonary emphysema especially were also measured by radioimmunoassay. Following results were obtained. 1) Twenty-four hours secretions of PGF-MUM in normal subjects were 18.4 +/- 9.1 microgram/day (24.5 +/- 9.2 microgram/day in male, 12.2 +/- 2.6 microgram/day in female) on an average. The values of PGF-MUM in male were significantly higher than those in female (P less than 0.03). 2) Twenty-four hours secretions of PGF-MUM for the patients with pulmonary emphysema were significantly lower (P less than 0.01) than those in the normal controls (P less than 0.01), and the values of PGF-MUM were correlated significantly (r=0.451, P less than 0.05) with arterial oxygen partial pressure. 3) Twenty-four hours secretions of PGF-MUM in the patients with asthma bronchiale, chronic bronchitis, hypersensitivity pneumonitis, pulmonary fibrosis and lung cancer were not significantly different from those in the normal controls. But, higher values of PGF-MUM were contained in the pulmonary fibrosis group, and the values of PGF-MUM were correlated with the serum LDH levels (r= 0.652, P less than 0.01). 4) The plasma PGF quantities were 0.7 +/- 0.5 ng/ml and the plasma PGE quantities were 1.7 +/- 0.6 ng/ml in normal subjects on an average. 5) The plasma PGF and PGE quantities in the patients with pulmonary emphysema were not significantly different from those in the normal controls. 6) A significant inverse correlation was observed between the decrease changes of pulmonary arterial pressures and the changes of plasma PGE quantities after oxygen inhalation for the patients with pulmonary emphysema (r= -0.737, P 0.01).
D000328:Adult; D000368:Aged; D000542:Alveolitis, Extrinsic Allergic / Q000378:metabolism; D001991:Bronchitis / Q000378:metabolism; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000097:blood / Q000378:metabolism* / Q000652:urine; D008175:Lung Neoplasms / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy; D011458:Prostaglandins E / Q000097:blood*; D011460:Prostaglandins F / Q000097:blood / Q000378:metabolism* / Q000652:urine; D011656:Pulmonary Emphysema / Q000378:metabolism / Q000628:therapy; D011658:Pulmonary Fibrosis / Q000378:metabolism; D012737:Sex Factors
D011458:Prostaglandins E; D011460:Prostaglandins F