[Tissue distribution of fortimicin used in the field of obstetrics].
A new aminoglycoside antibiotic, fortimicin, was administered intramuscularly at a dose of 200 mg, and the tissue distribution of the drug was investigated with time-course in the uterine fundus, uterine cervix, oviduct, endometrium and ovary. Patients who required total hysterectomy or uterine appendices resection due to uterine myoma, etc. were studied. The uterus levels of fortimicin were about 2 mcg/g at 2 hours after intramuscular administration in the uterine fundus and uterine cervix and reduced to trace after 8 approximately 9 hours. The genital organs levels of fortimicin were ranged from 0.71 to 4.6 mcg/g at 1 approximately 3 hours after intramuscular administration and then reduced to the levels of 0.79 mcg/g in the oviduct, of 0.25 mcg/g in the endometrium and of 0.45 mcg/g in the ovary after 5 hours.
D000617:Aminoglycosides / Q000008:administration & dosage / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D005836:Genitalia, Female / Q000378:metabolism*; D006801:Humans; D007273:Injections, Intramuscular; D013997:Time Factors; D014018:Tissue Distribution
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C023521:fortimicins