Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy.
A boy was born with a short sloping forehead, wide metopic suture, persistent metopic fontanelle, telecanthus, ocular hypertelorism, nystagmoid eye movements, bilateral cleft lip and palate, imperforate anus, rectourethral fistula, bifid scrotum and an unusual penis with hypospadias. The neutrophil polymorphs had numerous nuclear projections. The pregnancy was complicated by chronic maternal schizophrenia, severe toxaemia and maternal use of fluphenazine enanthate, dicyclomine hydrochloride, doxylamine succinate, pyridoxine hydrochloride and other drugs. Details of mother's illness, pregnancy and drug usage are presented with the clinical findings and investigations.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D002971:Cleft Lip / Q000139:chemically induced; D002972:Cleft Palate / Q000139:chemically induced; D004025:Dicyclomine / Q000009:adverse effects; D004319:Doxylamine / Q000009:adverse effects; D005260:Female; D005476:Fluphenazine / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D006972:Hypertelorism / Q000139:chemically induced; D007231:Infant, Newborn; D008297:Male; D010502:Perineum / Q000002:abnormalities; D011225:Pre-Eclampsia / Q000188:drug therapy; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D011736:Pyridoxine / Q000009:adverse effects; D012562:Schizophrenia, Disorganized / Q000188:drug therapy
D004025:Dicyclomine; D004319:Doxylamine; D011736:Pyridoxine; C017610:fluphenazine enanthate; D005476:Fluphenazine