Inhibition by early treatment with bromocriptine of spontaneous mammary tumour development in rats with no side-effects.
Temporary inhibition by CB-154 (bromocriptine) of pituitary prolactin secretion, which induced a decline in mammary gland DNA synthesis for 4-11 weeks of age, resulted in a marked suppression of spontaneous mammary tumour development in rats after one year of age. The treatment had no effect on reproduction and subsequent lactation immediately after the CB-154 injection or growth and function of the mammary glands and pituitary prolactin secretion in later life.
D000367:Age Factors; D000818:Animals; D001971:Bromocriptine / Q000009:adverse effects / Q000627:therapeutic use*; D004247:DNA / Q000096:biosynthesis; D005260:Female; D007774:Lactation / Q000187:drug effects; D008321:Mammary Glands, Animal / Q000378:metabolism; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy*; D009929:Organ Size; D011247:Pregnancy; D011270:Pregnancy, Animal; D011388:Prolactin / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction
D001971:Bromocriptine; D011388:Prolactin; D004247:DNA