Decreased membrane fragility of mouse erythrocytes by small dose of methylmercury and its restoration by coadministered selenite.
Female IVCS mice were fed methylmercury at a low dose level (10 nmoles/g feed) with coadministration of selenite (0, 8, 20 or 50 nmoles/ml of drinking water) for one week or two weeks. Mice fed methylmercury alone showed the decreased fragility of erythrocytes membrane when compared with the non-treated control. Coadministration of selenite produced such a change to smaller extents than methylmercury treatment alone. Mercury levels in the blood varied according to the dose level of selenite (the highest level was found in methylmercury alone group.)
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000187:drug effects*; D004912:Erythrocytes / Q000032:analysis / Q000187:drug effects*; D005260:Female; D006461:Hemolysis / Q000187:drug effects*; D008628:Mercury / Q000097:blood; D008767:Methylmercury Compounds / Q000494:pharmacology*; D051379:Mice; D009996:Osmotic Fragility / Q000187:drug effects; D020887:Selenious Acid; D012643:Selenium / Q000494:pharmacology*
D008767:Methylmercury Compounds; D020887:Selenious Acid; D008628:Mercury; D012643:Selenium