Effect of indomethacin incorporation on the retention of silastic intrauterine devices in the rat.
In order to observe the effects of indomethacin upon the retention of silastic intrauterine contraceptive devices, rods containing indomethacin at various loadings were inserted unilaterally into adult rats. In other animals, an unmedicated rod was inserted into one uterine horn whilst an indomethacin-loaded rod was fitted to the other horn. Rods were not secured to the uterine wall and the retention of rods in both groups was determined at weekly intervals. The results show an increased retention for animals fitted with indomethacin-loaded rods over a 4-week period. All unmedicated rods, irrespective of whether a contralateral indomethacin rod was present or not, were expelled by 1 week after insertion.
D000818:Animals; D005260:Female; D007213:Indomethacin / Q000008:administration & dosage*; D007434:Intrauterine Devices; D051381:Rats; D011919:Rats, Inbred Strains; D012826:Silicone Elastomers
D012826:Silicone Elastomers; D007213:Indomethacin