Nasal airway resistance in perennial non-allergic rhinitis. Postural variations and effects of topical application of terbutaline.
The nasal airway resistance in various positions of the body was investigated in 24 patients with perennial non-allergic rhinitis and in 10 normal subjects. No difference in nasal airway resistance between inspiration and expiration was found. the patients had higher resistance than the controls, a difference providing an anatomical explanation of their complaint of nasal obstruction. When the patients changed from the recumbent to the sitting position, the resistance did not decrease until after about one hour. The corresponding time for the controls was 10 minutes. This difference suggests that oedema is a more important cause of nasal swelling in the patients than in normal subjects. Local treatment of the patients' nasal mucosa with terbutaline revealed no clear oedema-reducing effect to the drug.
D000328:Adult; D000368:Aged; D000403:Airway Resistance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000187:drug effects; D009666:Nose / Q000503:physiopathology*; D011187:Posture; D012220:Rhinitis / Q000503:physiopathology*; D013726:Terbutaline / Q000494:pharmacology; D013997:Time Factors
D013726:Terbutaline