[Malignant hyperthermia. Current aspects of dantrolene treatment of 2 cases of hyperthermia maligna incipiens].
During induction with volatile anaesthetic agents and succinylcholine (suxamethonium) both children showed a singular clinical symptom: trismus. In the first case(1) narcosis had been interrupted followed by clinically controlled recovery. One week later, after treatment with oral dantrolen (Dantamacrin), anaesthesia with triggerfree agents was performed without complications. In the second case (2) anaesthesia has been continued by using triggerfree agents. Both children showed significant increases of Creatin-Kinase-activities over 5000 U/l after the interrupted narcosis (1) and postoperatively as being typical biochemical parameters for incipient hyperthermia maligna. All other parameters were normal. A review is given on the use of dantrolene-sodium, its development and its use in our department as lifesaving agent in malignant hyperthermia.
D002648:Child; D003620:Dantrolene / Q000627:therapeutic use*; D006801:Humans; D007021:Hypospadias / Q000601:surgery; D008297:Male; D008305:Malignant Hyperthermia / Q000175:diagnosis / Q000188:drug therapy*; D013737:Testis / Q000601:surgery
D003620:Dantrolene
Maligne Hyperthermie (MH). Aktuelles über die Dantrolenbehandlung anhand von 2 Fällen von Hyperthermia maligna incipiens.