[Investigations of the efficacy and bio-availability of different pilocarpine eye drops].
The efficacy of three pilocarpine preparations in different concentrations (pilocarpine borate 0.5%, 1%, 2%; pilocarpine hydrochloride 0.5%, 1%, 2%; pilocarpine nitrate 1%, 2%) was investigated in 57 glaucomatous patients. Pilocarpine borate reduced intraocular pressure more effectively than either of the other pilocarpine solutions. The 2% concentration had a particularly prolonged effect. This finding corresponded well with pilocarpine levels in the aqueous humour of rabbits, as determined by spectrophotometric analysis. Pilocarpine borate 2% revealed an almost two-fold amount of drug compared to the 2% hydrochloride and nitrate solutions, and a detectable pilocarpine level was present for a longer period as well.
D000328:Adult; D000368:Aged; D000818:Animals; D001682:Biological Availability; D005260:Female; D005901:Glaucoma / Q000188:drug therapy; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D010862:Pilocarpine / Q000378:metabolism / Q000494:pharmacology*; D011817:Rabbits
D009883:Ophthalmic Solutions; D010862:Pilocarpine
Untersuchungen über die Wirksamkeit und die Bioverfügbarkeit von verschiedenen Pilocarpin-Augentropfen.