Effect of intravenous epinephrine on cerebral cortical blood flow, oxygen tension, and high-energy phosphate metabolism after hypoxic hypotension.
An experimental model was examined in which rats were subjected to 30 minutes of hemorrhagic hypotension and hypoxia. In addition to resuscitation by infusion of blood and saline and increasing the fraction of inspired oxygen (FIO2), the possible beneficial effects of including intravenous epinephrine as part of the resuscitative regimen were studied. Mean arterial pressure, cortical microflow, and brain tissue oxygen tension were increased after epinephrine (P less than 0.05). Cortical ATP concentration was decreased after hypoxic hypotension and failed to improve after epinephrine.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002540:Cerebral Cortex / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology / Q000627:therapeutic use*; D006863:Hydrogen-Ion Concentration; D007022:Hypotension / Q000188:drug therapy*; D000860:Hypoxia / Q000188:drug therapy*; D007773:Lactates / Q000378:metabolism; D008297:Male; D010100:Oxygen / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains
D007773:Lactates; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D010100:Oxygen; D004837:Epinephrine