The effect of lactose on the intestinal absorption of calcium and zinc in the rat during maturation.
Lactose facilitates the intestinal absorption of several minerals and trace elements in postweanling rats. There is no information in the literature on the effect of lactose on the process of absorption in suckling rats. Because soy and elemental formulas are nonlactose-containing diets, the role of lactose in facilitating the intestinal absorption of minerals is of considerable nutritional importance. We studied therefore, the effect of water (control), lactose, sucrose, and glucose on the intestinal absorption and tissue uptake of calcium and zinc in the suckling (14-15 day old) and adolescent (42-43 day old) rats. Our results indicate that absorption of calcium and zinc was significantly greater in the suckling than in adolescent rats (P less than 0.01). Lactose enhanced significantly the absorption and tissue uptake of calcium and zinc in the adolescent rats compared to control and other sugars. In the suckling rats lactose had no effect on the intestinal absorption or tissue uptake of calcium and zinc compared to control and other sugars. The possible mechanism(s) responsible for our findings are discussed.
D000367:Age Factors; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology; D007408:Intestinal Absorption / Q000187:drug effects*; D007785:Lactose / Q000494:pharmacology*; D051381:Rats; D013395:Sucrose / Q000494:pharmacology; D015032:Zinc / Q000378:metabolism*
D013395:Sucrose; D005947:Glucose; D007785:Lactose; D015032:Zinc; D002118:Calcium