Do cytoprotective prostaglandins act as mild irritants?
Of the various mechanisms proposed to explain the cytoprotective properties of prostaglandins, mucus discharge seems the most probable. Mild irritants capable of eliciting mucus release have also been shown to exert cytoprotection. It is suggested that prostaglandins act as mild irritants of the mucosa and that cytoprotection is a mucosal reaction to mild irritation, through stimulation of mucus discharge.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004789:Enzyme Activation / Q000187:drug effects; D005753:Gastric Mucosa / Q000098:blood supply / Q000378:metabolism; D007477:Ions / Q000378:metabolism; D007509:Irritants; D009093:Mucus / Q000378:metabolism; D011453:Prostaglandins / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects
D007477:Ions; D007509:Irritants; D011453:Prostaglandins; D000262:Adenylyl Cyclases