Vascularization and radiocurability in cancer of the uterine cervix. A retrospective study.
The proportion of vascular elements in relation to the parenchymal and stromal components was determined by morphometric analysis of the histologic preparations from biopsies of uterine cervix cancers. In all cases, the material was obtained from tumors in Stages Ib and IIa before any therapy was initiated. In the 23 cases in which radiation treatment of the lesions resulted in a survival longer than 5 years, the proportion of blood vessels in the neoplastic tissue was found to be larger, and especially the stromal components were richer in vascular elements than in the 22 cases in which survival was shorter than 5 years. It was concluded that vascular density at least in cervical cancers of the stages studied can be a diagnostic parameter of a prognostic value as well as of a therapeutic usefulness.
D001706:Biopsy; D001918:Brachytherapy; D002294:Carcinoma, Squamous Cell / Q000098:blood supply* / Q000532:radiotherapy; D002584:Cervix Uteri / Q000473:pathology; D003037:Cobalt Radioisotopes / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D000860:Hypoxia; D011883:Radium / Q000627:therapeutic use*; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000098:blood supply* / Q000532:radiotherapy
D003037:Cobalt Radioisotopes; D011883:Radium