The influence of intraruminal and intraduodenal infusion of picolinic acid on metabolism of 65Zn in sheep.
Two experiments with sheep were carried out to study the influence of picolinic acid on zinc metabolism. In the first experiment, sheep were infused with water into the duodenum and with picolinic acid into the rumen or duodenum. All the sheep were then intraduodenally dosed with 65Zn. In the second experiment, sheep were intraduodenally infused with water or picolinic acid and then intravenously dosed with 65Zn. Necessary sampling of urine, faeces, blood or digesta were carried out in both experiments. The infusion with picolinic acid did not affect the faecal excretion or endogenous secretion of 65Zn but increased the urinary excretion of the radioisotope and ruminal solubility of zinc. However, te duodenal and ileal solubilities of zinc were not affected by the treatment. It was concluded that an exogenous supplement of picolinic acid is not effective in promoting higher absorption of zinc in ruminant animals.
D000818:Animals; D002404:Catheterization / Q000662:veterinary; D004386:Duodenum; D005243:Feces / Q000032:analysis; D006400:Hematocrit; D008297:Male; D010848:Picolinic Acids / Q000008:administration & dosage* / Q000378:metabolism; D012417:Rumen; D012756:Sheep / Q000378:metabolism*; D015032:Zinc / Q000097:blood / Q000378:metabolism*
D010848:Picolinic Acids; D015032:Zinc