[Optical tactics of antibacterial therapy for the trigger model of the infection process].
A problem is considered on optimal concentration of an antibacterial drug for the model of illness, in which the illness and health states of the host organism are identified with alternative stationary states of pathogenic microbe population. The total toxic effect of the drug and pathogenic microbes is minimized. The optical tactics is shown to depend first of all on the growth pattern of the drug toxic effect with the increase of its concentration. If the function approximating this relationship is arched upwards (small rise of the toxic effect) the maximal tolerable concentration of the drug is the optimal one. In other cases the "typical" optimal tactics is that under which the concentration of the drug in the beginning of treatment rapidly increases up to the maximal tolerable one, is maintained at this level for some time and then monotonously decreases to the end of treatment for a long time.
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D004334:Drug Administration Schedule; D006801:Humans; D008433:Mathematics; D008954:Models, Biological
D000900:Anti-Bacterial Agents
Ob optimal'noĭ taktike antibakterial'noĭ terapii dlia triggernoĭ modeli infektsionnogo protsessa.