Cerebrospinal fluid oestrone in pseudotumour cerebri.
The concentration of oestrone in the cerebrospinal fluid (CSF) from obese young women with pseudotumour cerebri was much greater than predicted and found in normal subjects. Each woman with pseudotumour cerebri, and a high level of CSF oestrone and a CSF protein less than 0·2 g/l, had clinical improvement when treated with an 800 calorie/day diet and dexamethasone 2 mg/day.
D000328:Adult; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D003907:Dexamethasone / Q000627:therapeutic use; D004038:Diet, Reducing; D004958:Estradiol / Q000134:cerebrospinal fluid; D004964:Estriol / Q000134:cerebrospinal fluid; D004970:Estrone / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects; D008599:Menstruation Disturbances / Q000134:cerebrospinal fluid; D009765:Obesity / Q000134:cerebrospinal fluid; D011559:Pseudotumor Cerebri / Q000134:cerebrospinal fluid*; D014424:Turner Syndrome / Q000134:cerebrospinal fluid
D002556:Cerebrospinal Fluid Proteins; D004970:Estrone; D004958:Estradiol; D003907:Dexamethasone; D004964:Estriol