Amoxapine-associated rhabdomyolysis and acute renal failure: case report.
Amoxapine, a new tricyclic antidepressant, has been recently released in the United States and Europe. There has been limited experience with amoxapine overdose, and no serious reactions or sequelae were observed in the reported cases. A case of amoxapine overdose associated with rhabdomyolysis and acute renal failure is reported. Amoxapine overdose could cause convulsions or prolonged coma leading to atraumatic rhabdomyolysis and myoglobinuric renal failure. Direct muscle or renal toxicity from this drug and its metabolites should not be excluded until evidence to the contrary is available. Acute renal failure should be looked for in cases of amoxapine overdose.
D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced*; D000328:Adult; D000657:Amoxapine / Q000506:poisoning*; D003128:Coma / Q000139:chemically induced; D003402:Creatine Kinase / Q000097:blood; D003404:Creatinine / Q000097:blood; D003989:Dibenzoxazepines / Q000506:poisoning*; D005260:Female; D006801:Humans; D009212:Myoglobinuria / Q000139:chemically induced*; D012640:Seizures / Q000139:chemically induced
D003989:Dibenzoxazepines; D003404:Creatinine; D003402:Creatine Kinase; D000657:Amoxapine