[Genetic activity of 1,2-dichloroethylene. B). In vivo studies: effect on microsomal enzymes].
Mutagenicity study "in vivo" (Intravenous host mediated assay) confirms suspension test results with cis- and trans -1,2-dichloroethylene: no genetic effects could be detected. Single and repeated doses of trans-1,2-DCE induced liver aminopyrine demethylase and cytochrome P-450 whereas the cis- isomer decreased them. Similar results were obtained after induction with phenobarbital + beta-Naphthoflavone.
D000633:Aminopyrine N-Demethylase / Q000096:biosynthesis; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004000:Dichloroethylenes / Q000633:toxicity*; D004790:Enzyme Induction; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D007536:Isomerism; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D051379:Mice; D008861:Microsomes / Q000201:enzymology*; D009152:Mutagenicity Tests
D004000:Dichloroethylenes; D006843:Hydrocarbons, Chlorinated; D003577:Cytochrome P-450 Enzyme System; D000633:Aminopyrine N-Demethylase; C035384:1,2-dichloroethylene
Attivita' genetica dell'1,2-dicloroetilene. B) Studio in vivo: effetto sugli enzimi microsomiali.