Inhibition of [3H]adenosine binding by stereoisomers of oxazepam hemisuccinate in guinea-pig brain synaptosomes.
1. The stereoisomers of oxazepam sodium hemisuccinate have been tested for their ability to inhibit the [3H]adenosine binding in guinea-pig brain synaptosomes. 2. All three stereoisomers were able to inhibit the [3H]adenosine binding in a dose-dependent fashion. 3. The IC20 values of the D-, DL- and L-stereoisomers were approximately 5 X 10(-5) M, 7.5 X 10(-5) M and 10(-4) M respectively. 4. The results are consistent with hypothesis that adenosine may be the endogenous substrata mediating some actions of the benzodiazepines.
D000241:Adenosine / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D010076:Oxazepam / Q000031:analogs & derivatives* / Q000494:pharmacology; D013237:Stereoisomerism; D013574:Synaptosomes / Q000378:metabolism*; D014316:Tritium
D014316:Tritium; D010076:Oxazepam; C023857:oxazepam hemisuccinate; D000241:Adenosine