Suppression of humoral and cellular immunity in normal mice by diazepam.
Diazepam, a benzodiazepine derivative useful in the treatment of anxiety disorders, was found to depress both primary antibody to sheep red blood cells and delayed-type hypersensitivity responses in normal mice. This immunodepressant activity warrants further investigation owing to its potential consequences on human health and the putative involvement of specific receptors on immunocompetent cells.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology*; D006384:Hemagglutination / Q000187:drug effects; D006388:Hemagglutinins / Q000032:analysis; D006968:Hypersensitivity, Delayed / Q000188:drug therapy; D007111:Immunity, Cellular / Q000187:drug effects*; D007166:Immunosuppressive Agents; D051379:Mice
D006388:Hemagglutinins; D007166:Immunosuppressive Agents; D003975:Diazepam