DNA content of pancreatic duct hyperplasia and carcinoma.
The DNA content of epithelial nuclei of hyperplastic and carcinomatous ducts of the pancreas was examined cytophotometrically. The materials were obtained from 2 cases of nonpapillary hyperplasia, 3 of papillary hyperplasia, 2 of atypical hyperplasia and 2 of tubular adenocarcinoma, which were selected by reviewing the pancreata of about 1,600 human autopsy cases. A gradual shift was observed in the DNA content from the normal level to a carcinomatous level through various stages of hyperplasia. Based on these findings, the hypothesis that pancreatic duct hyperplasia is a potent precursor of pancreatic carcinoma is discussed.
D000230:Adenocarcinoma / Q000032:analysis*; D002467:Cell Nucleus / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000032:analysis*; D004247:DNA / Q000032:analysis*; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D006965:Hyperplasia; D010183:Pancreatic Ducts / Q000032:analysis* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000032:analysis*
D004273:DNA, Neoplasm; D004247:DNA