High performance liquid chromatographic determination of primidone in tablets.
A high performance liquid chromatographic (HPLC) method is described for the quantitative determination of primidone in tablets. A ground tablet sample is diluted directly in the mobile phase, at a concentration of about 1 mg/mL of primidone, mixed and deaerated, and filtered. The resulting solution is then quantitated by HPLC. The average spike recoveries for the 50 mg and 250 mg tablets were 101.2% and 99.0%, respectively. The average recovery for an authentic mixture formulated at the 250 mg level was 100.1% with a relative standard deviation of 0.45%.
D002851:Chromatography, High Pressure Liquid; D011324:Primidone / Q000032:analysis*; D013607:Tablets / Q000032:analysis
D013607:Tablets; D011324:Primidone