Tolerance of young turkey poults to various combinations of dietary furazolidone and salt.
Three feeding trials were conducted to study the tolerance of young turkey poults to furazolidone and to various combinations of salt and furazolidone in the diet. Poults of mixed sexes tolerated up to 0.03% dietary furazolidone from hatch to six weeks of age without harmful effects as judged from the data on mortality rate, feed intake, body weight and plasma composition. High mortality with cardiac dilation and ascites occurred in poults fed the same basal diet containing 0.05 or 0.07% furazolidone. Mortality was positively related to levels of dietary furazolidone, and occurred mainly between two and four weeks of age. The cumulative feed intake and body weight of these poults were significantly lower than those of the control poults at six weeks of age. There was indication of decreased renal function in poults on high furazolidone intake and the mechanism of furazolidone-induced cardiac dilation is discussed. Mortality rate, incidence of cardiac dilation with ascites and heart, liver and body weights and feed efficiency were similar in poults fed diets containing 0.022% furazolidone and varying levels of salts (0.5, 1.0 or 1.5%) compared with the control fed the same basal diet containing 0.5% salt from hatch to eight weeks of age. It is concluded that a starter diet containing 0.022% furazolidone and up to 1.5% salt does not affect the performance of poults from hatch to eight weeks of age.
D000367:Age Factors; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004338:Drug Combinations; D004361:Drug Tolerance; D004435:Eating / Q000187:drug effects; D005260:Female; D005503:Food Additives / Q000494:pharmacology*; D005664:Furazolidone / Q000494:pharmacology*; D008297:Male; D009026:Mortality; D012965:Sodium Chloride / Q000494:pharmacology*; D014422:Turkeys / Q000097:blood / Q000502:physiology*
D004338:Drug Combinations; D005503:Food Additives; D012965:Sodium Chloride; D005664:Furazolidone