Effect of a scorpion (Leiurus quinquestriatus H and E) venom on blood gases and acid-base balance in the rat.
Leiurus quinquestriatus crude venom caused metabolic alkalosis which was partially compensated by respiratory acidosis. Fraction 1 of the venom caused metabolic and respiratory acidosis. The other fractions caused metabolic alkalosis with various degrees of compensation by respiratory acidosis. Fraction 1 caused a marked decrease in blood pH. Hypoxia seemed to be an important contributing factor for this change. Sodium levels decreased while potassium levels increased in the plasma.
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000818:Animals; D001784:Blood Gas Analysis; D006863:Hydrogen-Ion Concentration; D011188:Potassium / Q000097:blood; D051381:Rats; D012604:Scorpion Venoms / Q000494:pharmacology*; D012964:Sodium / Q000097:blood
D012604:Scorpion Venoms; D012964:Sodium; D011188:Potassium