Vitiligo with an inflammatory erythema in Vogt-Koyanagi-Harada disease: demonstration of filamentous masses and amyloid deposits.
A 35-year-old Japanese woman developed vitiligo with an inflammatory erythema on the face two years after the onset of bilateral uveitis and dysacusis. Histological studies of the lesions revealed the loss of pigment and dense mononuclear cell infiltration around the blood vessels. At the dermo-epidermal junction area, a few eosinophilic masses were found. Electron microscopy disclosed that the masses were filamentous masses (colloid bodies) and amyloid. After the oral administration of prednisolone, the erythema subsided, and the vitiligo showed some repigmentation.
D000328:Adult; D000682:Amyloid; D003102:Colloids; D004890:Erythema / Q000473:pathology*; D005148:Facial Dermatoses / Q000473:pathology*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000150:complications*; D006801:Humans; D008544:Melanocytes / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D012867:Skin / Q000648:ultrastructure; D013577:Syndrome; D014605:Uveitis / Q000150:complications*; D014820:Vitiligo / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*
D000682:Amyloid; D003102:Colloids; D011239:Prednisolone