[Use of inbred mice for assessing the neurovirulence of strains of the tick-borne encephalitis virus complex and the immunogenicity of a concentrated tick-borne encephalitis vaccine].
The sensitivity of different lines of inbred mice to strains of the tick-borne encephalitis complex viruses differing in their biological properties and the degree of attenuation was compared. The mice differing in their genetic characteristics and susceptibility to extraneurally inoculated virus were shown to have different immunological responsiveness to inoculation of an inactivated vaccine antigen.
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D004195:Disease Models, Animal; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology / Q000472:pathogenicity*; D004675:Encephalitis, Tick-Borne / Q000276:immunology / Q000382:microbiology*; D051379:Mice; D008815:Mice, Inbred Strains; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*; D014774:Virulence
D000956:Antigens, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines
Ispol'zovanie inbrednykh mysheĭ dlia otsenki neĭrovirulentnosti shtammov virusov kompleksa kleshchevogo éntsefalita i immunogennosti kontsentrirovannoĭ vaktsiny kleshchevogo éntsefalita.