Buccal uptake, urinary excretion, and physicochemical properties of zipeprol and its N-dealkylated products.
Buccal uptake, partition characteristics, ionization constants, and urinary excretion were studied for zipeprol and two of its metabolites. Buccal uptake, measured in a single subject, was found to be correlated with n-heptane/water (ph 7.4) partition values of the compounds, and with proportional excretion of the unchanged drug. The importance of the shape of buccal uptake-pH curves in the prediction of absorption and excretion of these compounds is discussed.
D002610:Cheek; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002849:Chromatography, Gas; D003640:Dealkylation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009061:Mouth Mucosa / Q000378:metabolism*; D010879:Piperazines / Q000378:metabolism* / Q000652:urine; D013055:Spectrophotometry, Infrared
D010879:Piperazines; C013341:zipeprol