The effect of ethanol administration on renal and hepatic mixed-function oxidases in the Fischer 344 rat.
Administration of ethanol in the drinking water increases hepatic cytochrome P-450 content and xenobiotic metabolism. However, the effect on renal xenobiotic metabolism has not been investigated. Chronic consumption of ethanol (15% solution in the drinking water) increased hepatic cytochrome P-450 content as well as ethoxycoumarin-O-deethylase, aniline hydroxylase and benzphetamine-N-demethylase activities. No change in renal cytochrome P-450 was detected after chronic ethanol consumption whereas ethoxycoumarin-O-deethylase activity in renal microsomes was significantly increased.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D007668:Kidney / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344
D000431:Ethanol; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases