Some new data to the toxicological effects of paraquat and the therapy.
1. Substances previously tested therapeutically were studied to obtain evidence on the pathomechanism in mice of paraquat, the active ingredient of Gramoxon, connected with the radicals formed from molecular oxygen, and also to extend the therapeutic possibilities. 2. The effects of these substances were assessed on the basis of the 72-hr survival rate and the percentage ratio of the wet lung weight to the overall body weight. 3. Other toxicological parameters too were followed. 4. Our present investigations indicate that, in agreement with our earlier results, besides reduced glutathione and ascorbic acid, vitamin E and C-ase are of the greatest importance from the aspect of the protection against paraquat toxicity. 5. In addition to those listed, other materials too, e.g. antifibrotic substances, naturally possess considerable detoxicating properties too.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D005260:Female; D005978:Glutathione / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010269:Paraquat / Q000633:toxicity*; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors
D000975:Antioxidants; D013482:Superoxide Dismutase; D005978:Glutathione; D010269:Paraquat