The third class of new tumor promoters, polyacetates (debromoaplysiatoxin and aplysiatoxin), can differentiate biological actions relevant to tumor promoters.
Aplysiatoxin is a new class of potent tumor promoter and debromoaplysiatoxin may be a weak promoter. Aplysiatoxin and debromoaplysiatoxin showed the same potency on irritation of mouse ear and induction of ornithine decarboxylase activity on mouse skin, but debromoaplysiatoxin was much weaker than aplysiatoxin in induction of adhesion of HL-60 cells.
D000818:Animals; D002273:Carcinogens; D002448:Cell Adhesion / Q000187:drug effects; D002449:Cell Aggregation / Q000187:drug effects; D002460:Cell Line; D004790:Enzyme Induction; D007783:Lactones / Q000494:pharmacology; D008235:Lyngbya Toxins; D008387:Marine Toxins / Q000494:pharmacology; D051379:Mice; D008978:Mollusk Venoms / Q000494:pharmacology; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009955:Ornithine Decarboxylase / Q000378:metabolism; D012867:Skin / Q000201:enzymology; D013329:Structure-Activity Relationship
D002273:Carcinogens; D007783:Lactones; D008235:Lyngbya Toxins; D008387:Marine Toxins; D008978:Mollusk Venoms; C017179:debromoaplysiatoxin; C006610:aplysiatoxin; D009955:Ornithine Decarboxylase