[Effect of serotonin on the lysosomal apparatus of liver cells and on hydrolase activity in the blood in severe mechanical injury].
A study was made of the pattern of changes in overall and non-sedimented activity of lysosomal hydrolases of the liver of rats injected with serotonin under grave mechanical trauma. Lability of the lysosomal membranes was found to be twice as increased, with remarkable hyperfermentemia being seen starting from the 3rd hour of compression in the presence of an appreciable rise of overall enzymatic activity. The role of serotonin in the mechanism of exocytosis of lysosomal enzymes is discussed.
D000818:Animals; D003444:Crush Syndrome / Q000188:drug therapy* / Q000201:enzymology; D004353:Drug Evaluation, Preclinical; D006867:Hydrolases / Q000097:blood*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000627:therapeutic use*; D012774:Shock, Traumatic / Q000188:drug therapy*; D013997:Time Factors
D012701:Serotonin; D006867:Hydrolases
Vliianie serotonina na lizosomal'nyĭ apparat kletok pecheni i aktivnost' gidrolaz v krovi pri tiazheloĭ mekhanicheskoĭ travme.