[Production of rabies vaccine in animal diploid cells].
Modalities for production of inactivated rabies vaccine derived from diploid hamster cell cultures are reported. The inactivated concentrated virus, purified by zonal centrifugation, is utilised for the preparation of vaccines destinated to carnivores, either in the form of monovalent vaccine or associated with distemper and canine contagious hepatitis vaccines. The inactivated concentrated virus is utilised for the preparation of bovine vaccine. The procedure is compatible with industrial production. The results concerning safety and potency tests of the experimental lots are presented.
D000818:Animals; D002417:Cattle; D002460:Cell Line; D006224:Cricetinae; D004171:Diploidy; D004355:Drug Stability; D007668:Kidney; D051379:Mice; D011819:Rabies Vaccines / Q000276:immunology / Q000302:isolation & purification*
D011819:Rabies Vaccines
Production d'un vaccin antirabique sur cellules diploides animales.