[GABA-ergic system components and lipid peroxidation in acute exogenous acrylonitrile poisoning].
A study was made of the content of biogenic amines as of a number of functions of the plasma membrane of hepatocytes and activity of lipid peroxidation during acute acrylonitrile poisoning. This industrial monomer stimulated all the parts of the sympatho-adrenal system and caused a reduction of the GABA level that is likely to be a consequence of inhibition of glutamate decarboxylase biosynthesis. Moreover, it was found that barrier and regulatory functions of the hepatocyte membrane were impaired. Accumulation of diene conjugates and protective action of alpha-tocopherol that prevented the development of the discovered stressor alterations point to a possible pathogenetic relationship between the disorders seen and poison-induced lipid peroxidation.
D000181:Acrylonitrile / Q000506:poisoning*; D000208:Acute Disease; D000818:Animals; D004837:Epinephrine / Q000378:metabolism; D005260:Female; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D009570:Nitriles / Q000506:poisoning*; D009638:Norepinephrine / Q000378:metabolism / Q000494:pharmacology; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D008054:Lipid Peroxides; D009570:Nitriles; D014810:Vitamin E; D005680:gamma-Aminobutyric Acid; D000181:Acrylonitrile; D009638:Norepinephrine; D004837:Epinephrine
Komponenty GAMK-ergicheskoĭ sistemy i perekisnoe okislenie lipidov pri ostroĭ ékzogennoĭ intoksikatsii akrilonitrilom.