Multiple neonatal screening for aminoacidopathies by ion exchange chromatography.
The experience gained in a pilot programme for multiple screening for amino acid disorders is reported. Over 222,000 newborn infants were screened by ion-exchange chromatography using dried blood spots. The acceptability, reliability and validity of the method are reported, and an outline is given, of the field evaluation of the method over 4 years, together with a short cost analysis. Incidences of the screened diseases and their differences from other reports are also discussed.
D000592:Amino Acid Metabolism, Inborn Errors / Q000175:diagnosis*; D000596:Amino Acids / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis*; D008403:Mass Screening
D000596:Amino Acids