[Noncholinesterase component in the molecular mechanism of action of the cholinesterase reactivator dipyroxime].
While changing the structure of the superficial layers of the serum albumin molecule, the cholinesterase reactivator dipyroxime increases the protein binding capacity as regards the organophosphorus poison dimethyldichlorovinyl phosphate. This may be conductive to the reduction of the latter's acute toxicity.
D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001798:Blood Proteins / Q000378:metabolism; D002801:Cholinesterase Reactivators / Q000494:pharmacology*; D004006:Dichlorvos / Q000633:toxicity; D006801:Humans; D010091:Oximes / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000378:metabolism; D013412:Sulfadimethoxine / Q000494:pharmacology; D014289:Trimedoxime / Q000494:pharmacology*
D001798:Blood Proteins; D002801:Cholinesterase Reactivators; D010091:Oximes; D012709:Serum Albumin; D013412:Sulfadimethoxine; D014289:Trimedoxime; D004006:Dichlorvos
Nekholinésteraznyĭ komponent v molekuliarnom mekhanizme deĭstviia reaktivatora kholinésterazy dipiroksima.