Lipid peroxidation during chronic inflammation induced in rats by Freund's adjuvant: effect of vitamin E as measured by expired pentane.
Expired pentane, a product of omega 6-unsaturated fatty acid hydroperoxide decomposition, and foot volume were measured following injection of Freund's adjuvant into the hind feet of vitamin E-deficient rats injected 1 wk previously with either 0 or 100 mg of dl-alpha-tocopherol acetate/100 g body weight. Vitamin E inhibited pentane production after 21 and 28 days. This is the first demonstration in vivo of increased lipid peroxidation and its inhibition by vitamin E during adjuvant-induced chronic inflammation. By 28 days, foot volume was significantly less in vitamin E-injected rats (162%) than in vitamin E-deficient rats (207%).
D000818:Animals; D005528:Foot / Q000473:pathology; D005620:Freund's Adjuvant / Q000494:pharmacology; D007249:Inflammation / Q000378:metabolism* / Q000473:pathology; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D010420:Pentanes / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013185:Squalene / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology*; D014811:Vitamin E Deficiency / Q000378:metabolism
D008054:Lipid Peroxides; D010420:Pentanes; D014810:Vitamin E; D013185:Squalene; D005620:Freund's Adjuvant