Effect of vasopressin on rat urinary prostaglandin excretion.
We studied the influence of rat renal prostaglandin on the effect of vasopressin, in vivo. In water-loaded rats, vasopressin induced a dose-related increase in total urinary prostaglandin E and prostaglandin F excretion and a decrease in total urine output. Urine excretion, which peaked in water-loaded controls during the first 2 h after loading, was suppressed in vasopressin-treated rats, however, their urinary prostaglandin E excretion was markedly enhanced. This increase in urinary prostaglandin E was suppressed by the simultaneous administration of indomethacin, and the 3-6 h post-administration peak in urine output of vasopressin-treated rats was inhibited. In hypophysectomized rats, urine excretion increased gradually after surgery, however, urinary prostaglandin E excretion decreased. Based on our present findings, we suggest that prostaglandin E produced in the rat kidney modulate the renal response to vasopressin.
D000818:Animals; D007016:Hypophysectomy; D007213:Indomethacin / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011188:Potassium / Q000378:metabolism; D011453:Prostaglandins / Q000652:urine*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism; D014667:Vasopressins / Q000494:pharmacology*
D011453:Prostaglandins; D014667:Vasopressins; D012964:Sodium; D011188:Potassium; D007213:Indomethacin