Effects of pentoxifylline on cell shape, ATP content and deformability in rabbit erythrocytes under hyperosmolar conditions.
1. Pentoxifylline (I) [3,7-dimethyl-1-(5-oxo-hexyl)-xanthine] (0-10(-3) M) inhibited the discocyte echinocyte transformation caused by hyperosmolarity and improved the impaired filtrability of erythrocytes due to hyperosmolarity. 2. The ATP content of erythrocytes was increased at low concentrations (0-3 x 10(-5) M) of I, but decreased at high concentrations (3 x 10(-5) M or above) of I.
D000255:Adenosine Triphosphate / Q000097:blood*; D000818:Animals; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects*; D008855:Microscopy, Electron, Scanning; D009994:Osmolar Concentration; D010431:Pentoxifylline / Q000494:pharmacology*; D011817:Rabbits; D013805:Theobromine / Q000031:analogs & derivatives*
D000255:Adenosine Triphosphate; D013805:Theobromine; D010431:Pentoxifylline