Haloperidol teratogenicity in the fetal hamster.
Haloperidol, administered as a single intraperitoneal injection on day 8 of gestation, produced a variety of fetal malformations in hamsters. Fetal defects included exencephaly, cranioschisis, microphthalmia, anophthalmia, lower body hypodevelopment, and total body hypodevelopment. A dose-response relationship was evident as 80-245 mg/kg produced from 3 to 70% fetal anomalies.
D000014:Abnormalities, Drug-Induced / Q000473:pathology; D000818:Animals; D006224:Cricetinae; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D005508:Food Deprivation; D006220:Haloperidol / Q000633:toxicity*; D008647:Mesocricetus; D011247:Pregnancy; D013723:Teratogens; D014868:Water Deprivation
D013723:Teratogens; D006220:Haloperidol