Build-up maintenance of IgG serum concentrations with intravenous immunoglobulin in patients with primary humoral immunodeficiency.
6 patients with antibody deficiency disease had intravenous immunoglobulin substitution and their serum IgG levels were monitored for at least 6 months. After three IgG infusions of 6-12 g each at intervals of 3 or 4 weeks, the IgG serum concentrations were between 300 and 500 mg/dl in 3 patients. In the 3 other patients, higher serum levels were obtained after considerably more IgG infusions given at intervals of 8 days or less. Maintenance of subnormal levels was achieved by replacement of approximately 10 mg/kg body weight/day. In 1 patient, the serum IgG was kept at about 1,000 mg/dl by replacement of 54 mg/kg/day, i.e. by infusions of 9 g every 3-4 days.
D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000276:immunology / Q000628:therapy*; D001835:Body Weight; D004306:Dose-Response Relationship, Immunologic; D006207:Half-Life; D006801:Humans; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000032:analysis* / Q000378:metabolism; D007136:Immunoglobulins / Q000008:administration & dosage*; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010953:Plasma Volume
D007074:Immunoglobulin G; D007136:Immunoglobulins