Effects of Loxosceles laeta spider venom on blood coagulation.
The hematologic effects of intradermal injection of Loxosceles laeta venom in rabbits were studied with special reference to partial thromboplastin time, prothrombin time, platelet count and fibrinogen-fibrin degradation products. The in vitro effect of Loxesceles laeta venom on human platelet aggregation was also studied. Fibrinogen and platelet count decreased and fibrinogen-fibrin degradation products increased at 12 hr.
D000818:Animals; D001180:Arthropod Venoms / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D008297:Male; D010976:Platelet Count; D011817:Rabbits; D013111:Spider Venoms / Q000494:pharmacology*
D001180:Arthropod Venoms; D005338:Fibrin Fibrinogen Degradation Products; D013111:Spider Venoms; D005340:Fibrinogen