The role of the randomized clinical trial in the evaluation of new operations.
Randomized trials that compare new operations with old ones or new regimens of invasive therapy with standard operations can make a substantial contribution to medical knowledge if the stipulations outlined in this article are followed. However, randomized trials that compare medical with surgical therapy have a number of additional problems and as a result rarely have a major impact on the practice of medicine.
D002986:Clinical Trials as Topic / Q000379:methods*; D006040:Goals; D006801:Humans; D010361:Patients; D011897:Random Allocation; D012107:Research Design; D013514:Surgical Procedures, Operative