Evaluation of spasmolytic activity of clausmarin-A. a novel coumarin from Clausena pentaphylla (Roxb.) DC.
Crude ethanolic (50%) extracts of five species of Clausena exhibited varying degrees of spasmolytic activity on the isolated guinea-pig ileum preparation. The aerial parts of Clausena pentaphylla had maximum activity. Its active principle clausmarin-A, a novel coumarin terpenoid, was evaluated in detail for spasmolytic activity in various in vivo and in vitro test models. The activity of clausmarin A compared favourably with that of papaverine.
D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D001980:Bronchi / Q000187:drug effects; D002415:Cats; D003374:Coumarins / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D005769:Gastrointestinal Motility; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007583:Jejunum / Q000187:drug effects; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics; D010936:Plant Extracts / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D014599:Uterus / Q000187:drug effects
D000779:Anesthetics, Local; D003374:Coumarins; D010276:Parasympatholytics; D010936:Plant Extracts; C035875:clausmarin