[Dispersion analysis used for assessing the anticonvulsant activity of 1,4-benzodiazepines].
A study was made of the time course of alterations in the convulsant activity of corazol after injection to mice of 1,4-benzodiazepine derivatives with different chemical structure. Significant anticonvulsant effect of benzodiazepines was observed for 5--120 minutes and was regarded a dynamic index. The maximal action of the drugs was observed within 15--30 minutes. The most pronounced anticonvulsant action was recorded after administering phenazepam and its 3-hydroxyderivative. The dependence of the anticonvulsant effect on the time of experiment and structure of the test compounds was examined by single-factor analysis of variance. The results demonstrate the relationship of differences in the anticonvulsant effects to the time factor and differences in the structure of the test compounds.
D000704:Analysis of Variance; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use*; D003292:Convulsants / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010433:Pentylenetetrazole / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D013997:Time Factors
D000927:Anticonvulsants; D003292:Convulsants; D001569:Benzodiazepines; D010433:Pentylenetetrazole
Ispol'zovanie dispersionnogo analiza dlia otsenki protivosudorozhnoĭ aktivnosti 1,4-benzodiazepinov.