A simple method for obtaining chronic cerebrospinal fluid samples from awake rats.
A simple technique is described for taking repeated cerebrospinal fluid (CSF) samples from the cisterna magna of unanesthetized rats. The technique has the advantages that inexpensive, readily available materials are used, the cannulas remain patent for extended periods of time, and large volumes of CSF can be obtained.
D000818:Animals; D002404:Catheterization / Q000379:methods*; D002555:Cerebrospinal Fluid; D051381:Rats; D014851:Wakefulness