State-related cyclical dyskinesias in manic-depressive illness.
Cyclical dyskinesias in two rapidly cycling manic-depressive patients recurred during depression and disappeared during mania. One case is reviewed in detail including findings of a 2-year follow-up. Spinal fluid biochemical data are presented and discussed. The finding of a reversible neurological alteration associated with changes in clinical state is of interest in relationship to the mechanisms underlying tardive dyskinesia and also provides evidence of a biological dysfunction in manic-depressive illness.
D000328:Adult; D001714:Bipolar Disorder / Q000503:physiopathology*; D004409:Dyskinesia, Drug-Induced / Q000209:etiology* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000134:cerebrospinal fluid; D011339:Probenecid / Q000494:pharmacology; D011569:Psychiatric Status Rating Scales; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000134:cerebrospinal fluid
D005680:gamma-Aminobutyric Acid; D011339:Probenecid; D009638:Norepinephrine