Anti-metrazol effects of nitrazepam during ontogenesis in the rat.
Anti-metrazol effect of nitrazepam was studied in male rats aged 7, 12, 18 and 90 days. Nitrazepam protected all age groups against seizures elicited by metrazol (80 mg/kg s.c.); the 50%-protective dose decreased from 165.7 micrograms/kg in adult rats to 70.2 micrograms/kg in 7-day-old animals. The sensitivity of 7-day-old and adult rats to metrazol is nearly the same, so that we may conclude that nitrazepam exhibits higher anti-metrazol potency in 7-day-old rats than in adult ones.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D008297:Male; D009567:Nitrazepam / Q000494:pharmacology*; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced*
D009567:Nitrazepam; D010433:Pentylenetetrazole