Liver pathology in fatal drug addiction.
Liver sections from 273 drug addicts submitted to medicolegal autopsy at the Institute of Forensic Medicine in Copenhagen in the period 1975-1979 were studied. In 65% of the cases non-specific portal inflammation only was found. Birefringent material--identified as the mineral talc (magnesium silicate) was observed in 38% of the cases; in these cases non-specific portal inflammation was always present. Changes compatible with acute or chronic persistent hepatitis or hepatitis sequelae were observed in 8% of the cases; cirrhosis in 3%. HBs-antigens were detected in 4%. In 22% fatty infiltration was present; in 4% as the only abnormal finding. Finally no pathological changes were found in 6%. The results were related to anamnestic information of kind and duration of drug abuse and to the cause of death. Furthermore a comparison was performed between the groups with and without birefringent material. The data suggest that the birefringent material may be of importance to the pathogenesis of the non-specific portal inflammation.
D000293:Adolescent; D000328:Adult; D001718:Birefringence; D004577:Electron Probe Microanalysis; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000209:etiology / Q000473:pathology; D008297:Male; D011168:Portal System / Q000473:pathology; D019966:Substance-Related Disorders / Q000150:complications / Q000473:pathology*; D013627:Talc / Q000032:analysis
D013627:Talc