Stage-specific cross-resistance between Nippostrongylus brasiliensis and Strongyloides ratti (Nematoda) in rats.
Stage-specificity of cross-resistance between Nippostrongylus brasiliensis and Strongyloides ratti was investigated. Results showed that immunization with tissue-migrating larvae was sufficient to generate cross-resistance and that host defense mechanisms operating in the cross-resistance were directed against tissue-migrating larvae but not against intestinal adult worms. In addition, no significant potentiation of the cross-resistance was observed after multiple immunization. These observations suggest that host defense mechanisms against heterologous challenge infection were qualitatively and/or quantitatively different from those against homologous challenge infection.
D000818:Animals; D003429:Cross Reactions; D005260:Female; D006725:Hookworm Infections / Q000276:immunology / Q000469:parasitology; D007109:Immunity; D007114:Immunization; D009559:Nippostrongylus / Q000254:growth & development / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D013321:Strongyloides / Q000254:growth & development / Q000276:immunology*; D013322:Strongyloidiasis / Q000276:immunology / Q000469:parasitology