Immunogenicity in chimpanzees of experimental hepatitis B vaccines prepared from intact hepatitis B virus, purified polypeptides, or polypeptide micelles.
The immunogenicity of three experimental hepatitis B vaccines was evaluated in chimpanzees. Although no antibody to hepatitis B surface antigen (anti-HBs) was detected in two chimpanzees that received an aqueous polypeptide vaccine subcutaneously, a strong anti-HBs response was observed two and ten weeks, respectively, following challenge with hepatitis B virus. Inoculation of two additional chimpanzees with a micellar preparation of these polypeptides by the intravenous route resulted in anti-HBs production in one of the chimpanzees. Two chimpanzees inoculated subcutaneously with an aqueous vaccine of formalin-inactivated intact hepatitis B virus developed anti-HBs in low titers, but the development of antibody to the hepatitis B core antigen following challenge inoculations suggested that subclinical HBV infections may have occurred despite prior vaccination.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D005260:Female; D006510:Hepatitis B Antibodies / Q000096:biosynthesis*; D006515:Hepatitis B virus / Q000276:immunology*; D008297:Male; D008823:Micelles; D002679:Pan troglodytes; D010455:Peptides / Q000276:immunology; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D006510:Hepatitis B Antibodies; D008823:Micelles; D010455:Peptides; D014613:Vaccines, Attenuated; D014764:Viral Proteins; D014765:Viral Vaccines