[Effectiveness of a combination of remantadine and ribamide administered by aerosol in experimental influenzal infection in white mice].
The effectiveness of remantadine, ribamide, and combination there of administered in aerosol on experimental influenza A/Aichi/2/68 virus infection in white mice was studied. Each of the drugs used alone was found to produce significant reduction in the mortality rate. Use of the drugs in combination both for therapeutic-prophylactic and for therapeutic purposes is of the additive nature, reducing the mortality of the animals by 50% as compared with the control group.
D000218:Adamantane / Q000031:analogs & derivatives*; D000336:Aerosols; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D012254:Ribavirin / Q000008:administration & dosage*; D012263:Ribonucleosides / Q000008:administration & dosage*; D012299:Rimantadine / Q000008:administration & dosage*; D013997:Time Factors
D000336:Aerosols; D012263:Ribonucleosides; D012299:Rimantadine; D012254:Ribavirin; D000218:Adamantane
Izuchenie éffektivnosti kombinatsii remantadina i ribamida pri ikh aérozol'nom vvedenii na éksperimental'nuiu grippoznuiu infektsiiu belykh mysheĭ.