Comparative effects of ionic anc nonionic contrast materials on coronary and peripheral blood flow.
Contrast materials may alter coronary blood flow (CBF) by a direct vasodilating action or indirectly by changing determinants of myocardial oxygen requirements (MVO2). The current study compared the vasodilatory actions of ionic (Renografin 76, R76) and nonionic contrast materials (iohexol and metrizamide) after direct injection into the coronary and femoral circulation of anesthetized dogs. R76 did not cause a significantly greater increase in CBF compared with nonionic materials in spite of causing significantly greater increases in osmolality of blood in the coronary sinus. Concomitant with the peak increase in CBF, the ionic materials caused sharp decrease in peak left ventricular (LV) systolic pressure and dp/dt, while the nonionic materials increased these major determinants of MVO2. In contradistinction to the effects on CBF, ionic contrast material caused substantially and significantly greater increase in femoral blood flow, compared with the nonionic materials. In conclusion, these studies infer that the increase in CBF with contrast materials involves both indirect vascular and metabolic actions, while the increase in FBF is due to a direct vascular action.
D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D003287:Contrast Media / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects*; D003973:Diatrizoate / Q000494:pharmacology; D003974:Diatrizoate Meglumine / Q000494:pharmacology; D004285:Dogs; D004338:Drug Combinations / Q000494:pharmacology; D005263:Femoral Artery / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics; D007472:Iohexol; D008793:Metrizamide / Q000494:pharmacology; D009994:Osmolar Concentration; D012039:Regional Blood Flow / Q000187:drug effects; D014283:Triiodobenzoic Acids / Q000494:pharmacology
D003287:Contrast Media; D004338:Drug Combinations; D014283:Triiodobenzoic Acids; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D007472:Iohexol; C027278:urovision; D008793:Metrizamide