[Effect of sombrevin and sodium oxybutyrate on the excitable membranes of a frog neuromuscular preparation].
Comparative evaluation of the effect of sombrevine and sodium hydroxybutyrate on the frog neuromuscular preparation with the use of intra- and exocellular recording of the drug-induced electrophysiological effects has shown that sombrevine inhibits the function of the excitable cell membranes whatever their functional specificity at the expense of interaction with lipid matrix of the membranes. The action of sodium hydroxybutyrate is determined by diminution of anion conduction of the excitable membranes and by an increase in their electrical resistance, which determines the hyperpolarizing action and stimulation of neuromuscular transmission in the frog skeletal muscle.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D004558:Electric Stimulation; D006885:Hydroxybutyrates / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009412:Nerve Fibers / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D011410:Propanidid / Q000494:pharmacology*; D011895:Rana ridibunda; D012978:Sodium Oxybate / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects
D006885:Hydroxybutyrates; D012978:Sodium Oxybate; D011410:Propanidid
Deistvie sombrevina i natriia oksibutirata na vozbudimye membrany nervno-myshechnogo preparata liagushki.