The use of meptazinol as a premedication for surgical patients.
The acceptability of a mixture of meptazinol and hyoscine as a surgical premedication was compared with that of an Omnopon-hyoscine combination in a randomized, double-blind trial involving 101 surgical patients. Blood pressure and respiratory rate were significantly reduced to a similar extent by both premedicant combinations, and this may be interpreted as evidence of a satisfactory alleviation of anxiety by both test mixtures. The two mixtures produced a similar degree of sedation, and both were associated with a useful inhibition of salivary secretion. Side-effects were reported in 25% patients in the meptazinol group, and in 28% of those receiving Omnopon, although a number of these effects may be attributable to hyoscine. There was no difference in the pattern of post-operative analgesic requirements between the two groups, and no unfavourable interaction was noted with any of the anaesthetic agents used.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001381:Azepines / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008621:Meptazinol / Q000008:administration & dosage*; D008875:Middle Aged; D009892:Opium / Q000008:administration & dosage; D011229:Preanesthetic Medication; D011897:Random Allocation; D012119:Respiration / Q000187:drug effects; D012601:Scopolamine / Q000008:administration & dosage; D013514:Surgical Procedures, Operative
D001381:Azepines; D008621:Meptazinol; D009892:Opium; D012601:Scopolamine