Short term effects of timolol in chronic glaucoma. A double blind study using computerized perimetry.
15 patients with glaucomatous field defects in at least one eye were subjected to computerized perimetry and IOP, systemic blood pressure and pulse rate measurements before and after timolol or placebo instillation in both eyes. A significant decrease of IOP and pulse rate was found 2 h after timolol. The visual fields were not improved, the correlation between IOP and visual field performance being (though not significantly) positive. The lack of improvement could not be attributed to the decrease in pulse rate.
D000368:Aged; D002908:Chronic Disease; D004311:Double-Blind Method; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000627:therapeutic use*; D013999:Timolol / Q000494:pharmacology / Q000627:therapeutic use*; D014065:Tonometry, Ocular; D058609:Visual Field Tests / Q000295:instrumentation / Q000379:methods; D014794:Visual Fields
D011412:Propanolamines; D013999:Timolol