Urinary retention during i.m. and extradural morphine analgesia.
In the postoperative period fifty-six healthy patients undergoing cholecystectomy or operations for duodenal ulcer, received, in a randomized order, i.m., "high-level" or "low-level" extradural morphine. Thirty-five per cent in the i.m. group, 33% in the high-level group and 50% in the low-level group suffered urinary retention, in all cases within the first 24 h. The mean cumulative dose of morphine necessary for pain relief was in the same range (13.4-16.5 mg) during the first 2 h of therapy for all groups, while the amounts after 24 and 48 h were twice to four times with the i.m. route compared with the extradural route. A peripheral effect of morphine on the urinary bladder is possible and the mechanism of action is discussed.
D000328:Adult; D002763:Cholecystectomy; D004381:Duodenal Ulcer / Q000601:surgery; D004824:Epidural Space; D006801:Humans; D007267:Injections; D007273:Injections, Intramuscular; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy*; D014555:Urination Disorders / Q000139:chemically induced*
D009020:Morphine