Beneficial effect of ethamsylate on the relative blood flow of the pancreas in acute canine necrotizing pancreatitis.
The beneficial effect of ethamsylate in maintaining the relative pancreatic blood flow in acute canine necrotizing pancreatitis has been demonstrated. This beneficial effect is a function of the action of the drug in tending to maintain pancreatic blood flow, thereby minimizing the significant decrease which normally occurs in this parameter in acute necrotizing pancreatitis. The exact mechanism of action of the drug is unclear. Concurrent measurements of oxygen consumption by the pancreas show an apparent beneficial trend in the ethamsylate-treated group, although this was not proved to be statistically significant.
D000208:Acute Disease; D000818:Animals; D001557:Benzenesulfonates / Q000627:therapeutic use*; D002302:Cardiac Output; D004285:Dogs; D004979:Ethamsylate / Q000627:therapeutic use*; D009336:Necrosis; D010101:Oxygen Consumption; D010179:Pancreas / Q000098:blood supply* / Q000378:metabolism; D010195:Pancreatitis / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D012039:Regional Blood Flow
D001557:Benzenesulfonates; D004979:Ethamsylate