Clinical trial of met-enkephalin analogue (DAMME, FK 33-824) on heroin abusers.
Twenty cases of hard-core heroin abusers were treated by detoxification with DAMME (Sandoz FK 33-824). It was found that 55% (n = 11) were detoxified in seven days and were satisfied with analogue. The abstinence period, during post-treatment follow-up, varied from two days to six months. The withdrawal syndrome scoring was significant in this group but not in the failure group (45% (n = 9)). No sign of tolerance to DAMME was noted in this series.
D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006556:Heroin Dependence / Q000534:rehabilitation*; D006801:Humans; D008297:Male
D004744:Enkephalin, Methionine; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin