The effect of leukotriene C4 on mucin release into the cat trachea in vivo and in vitro.
We have tested the effect of leukotriene C4 (LTC4, 6 X 10(-8) to 6 X 10(-5) M) on the output of radiolabelled mucins from the trachea of the anaesthetized cat. Doses between 6 X 10(-7) M and 6 X 10(-5) M stimulated mucin release. FPL 55712 (9.5 X 10(-6) M) partially antagonized the effect of the highest dose of LTC4. Tests of LTC4 (6 X 10(-8) to 6 X 10(-6) M) on cat trachea in vitro failed to show any effect on mucin secretion. We conclude that leukotrienes may be one of the mediators of mucus secretion into the inflamed airway.
D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D009077:Mucins / Q000378:metabolism*; D013189:SRS-A / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects / Q000378:metabolism*
D009077:Mucins; D013189:SRS-A