Cytotoxicity of chloropeptide in isolated hepatocytes and its inactivation by microsomes.
Chloropeptide, a hepatotoxic mycotoxin of Penicillium islandicum Sopp, induces gross changes in cell morphology including blebbing and ballooning of the cytoplasmic membrane in the isolated hepatocytes, and this hepatotoxic potential of chloropeptide is abolished by microsomal cytochrome P-450 system.
D000818:Animals; D001219:Aspartate Aminotransferases / Q000032:analysis; D002470:Cell Survival / Q000187:drug effects; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology; D066298:In Vitro Techniques; D008658:Inactivation, Metabolic; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D009183:Mycotoxins / Q000633:toxicity*; D010456:Peptides, Cyclic / Q000378:metabolism / Q000633:toxicity*; D051381:Rats
D009183:Mycotoxins; D010456:Peptides, Cyclic; C018925:chloropeptide; D003577:Cytochrome P-450 Enzyme System; D001219:Aspartate Aminotransferases