Recurrence of respiratory depression following neurolept analgesia.
Fentanyl, though generally regarded as a short-acting narcotic analgesic, can give unexpected respiratory depression several hours after the last dose. This potentially very dangerous effect is explained in pharmacokinetic studies by a mobilisation of fentanyl from tissue stores. In this report we describe a patient who, following a Harrington correction for scoliosis done with neurolept analgesia, developed a severe respiratory depression 5 h after the last dose of fentanyl.
D000328:Adult; D001285:Atropine; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005283:Fentanyl / Q000009:adverse effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007442:Intubation, Intratracheal; D007700:Kinetics; D009458:Neuroleptanalgesia / Q000009:adverse effects*; D012120:Respiration Disorders / Q000139:chemically induced*
D001285:Atropine; D005283:Fentanyl