Application of loop diuretics for treatment of sensorineural hearing impairment. Experimental and clinical study.
In a series of animal experiments on guinea pigs and rats, conducted in an attempt to find a better solution for the treatment of sensorineural hearing impairment and tinnitus-known as diseases almost impossible to heal-it was revealed electrophysiologically, biochemically and electronmicroscopically that loop diuretics, referred to as ototoxic drugs, cause an increased amount of the therapeutic preparation to transfer to the inner ear fluid. It is concluded, on the basis of the encouraging results of these experiments, that combined medication with metabolic activator, steroid hormone and loop diuretics is significantly more effective in improving the symptoms of patients with inner ear deafness and tinnitus.
D000818:Animals; D005665:Furosemide / Q000627:therapeutic use*; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced / Q000188:drug therapy*; D007612:Kanamycin; D007761:Labyrinthine Fluids; D051381:Rats; D011919:Rats, Inbred Strains
D007612:Kanamycin; D005665:Furosemide