Steroid hormone receptors in female breast angiosarcomas.
Breast angiosarcoma is an extremely rare neoplasm usually affecting premenopausal women. Previous reports suggest that it is hormone-dependent. A case of primary breast angiosarcoma in a 16-year-old patient is presented in which the presence of estradiol, progesterone, and testosterone receptors was investigated. The histological findings initially revealed a simple angioma, but four months later the histological picture had completely changed, showing an angiosarcoma. Our data indicate a lack of receptors for steroid hormones in this tumor, which argues against the hypothesis presented in the literature.
D000293:Adolescent; D001943:Breast Neoplasms / Q000032:analysis*; D004958:Estradiol / Q000032:analysis; D005260:Female; D006390:Hemangioendothelioma / Q000032:analysis*; D006801:Humans; D009376:Neoplasms, Hormone-Dependent / Q000032:analysis*; D011944:Receptors, Androgen; D011959:Receptors, Estradiol; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D011987:Receptors, Steroid / Q000032:analysis*; D013739:Testosterone / Q000032:analysis
D011944:Receptors, Androgen; D011959:Receptors, Estradiol; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011987:Receptors, Steroid; D013739:Testosterone; D004958:Estradiol