The effects of salbutamol, theophylline and FPL55712 on leukotriene contraction of guinea pig trachea.
Contraction of guinea pig tracheal smooth muscle was induced by leukotriene C4 or leukotriene D4. The inhibition of the smooth muscle contraction by salbutamol and theophylline was compared with the inhibition by FPL 55712. Salbutamol (5 X 10(-8) - 5 X 10(-7) M) significantly inhibited the leukotriene-induced contraction. The degree of inhibition was greater than that observed with FPL55712 (10(-6) - 10(-4) M). Theophylline (10(-6) - 10(-4) M) did not affect the leukotriene-induced contraction, but enhanced the effect of salbutamol when these agents were combined.
D000403:Airway Resistance / Q000187:drug effects*; D000420:Albuterol / Q000494:pharmacology*; D000818:Animals; D002867:Chromones / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D013189:SRS-A / Q000494:pharmacology*; D013806:Theophylline / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects
D002867:Chromones; D013189:SRS-A; C006312:FPL 55712; D013806:Theophylline; D000420:Albuterol