[Interrelations and characteristics of adrenergic and thyroid regulation of the enzymes of energy metabolism].
In experiments on albino male rats it was detected that noradrenaline and adrenoxyl intensify the triiodothyronine-125I binding in myocardial and hepatic nucleus mitochondria. Under the action of adrenaline, triiodothyronine the binding is activated in myocardial mitochondria and is diminished in the cardias and hepatic nuclea. Thyroxin and adrenoxyl enhance noradrenaline-3H uptake by the auricular, myocardial and hepatic sections. Noradrenaline lowers noradrenaline-3H uptake by the auricular and myocardial sections. Hyperthyroidization is accompanied by a decrease in noradrenaline-3H uptake. beta-Adrenoreceptor block does not alter the thyroxine effect on the myocardial and hepatic succinatedehydrogenase, as well as on the hepatic ATPase. alpha-adrenoreceptor block does not influence the thyroxin effect upon the myocardial ATPase, but abolishes its activating action on the hepatic succinatedehydrogenase and ATPase. Realization of several thyroxin effects is associated to some extent with a functional adrenergic state. Catecholamine action on some mitochondrial enzymes is significantly stipulated by the effects of their monoamine oxidase and quinoid transformation products. The quinoid oxidation products of catecholamine render a regulatory effect both during the catecholamine and thyroid hormone accumulation stage and on the level of mitochondrial enzyme reception.
D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D004734:Energy Metabolism; D006980:Hyperthyroidism / Q000201:enzymology; D007037:Hypothyroidism / Q000201:enzymology; D008297:Male; D008929:Mitochondria, Heart / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D051381:Rats; D011941:Receptors, Adrenergic / Q000378:metabolism*; D013961:Thyroid Gland / Q000201:enzymology*; D013963:Thyroid Hormones / Q000378:metabolism; D013965:Thyroidectomy
D002395:Catecholamines; D011941:Receptors, Adrenergic; D013963:Thyroid Hormones
Vzaimootnosheniia i osobennosti adrenergicheskoĭ i tireoidnoĭ reguliatsii fermentov énergeticheskogo obmena.