Transmethylation of phosphatidylethanolamine: an initial event in embryonic chicken lens fiber cell differentiation.
Agents that induce differentiation of lens epithelial cells into lens fiber cells in vitro transiently stimulate the transmethylation of phosphatidylethanolamine. Inhibition of transmethylation by 3-deazaadenosine results in a corresponding inhibition of the cell elongation that characterizes lens fiber formation, suggesting that phospholipid methylation plays an essential role in the differentiation of these cells.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002642:Chick Embryo; D007908:Lens, Crystalline / Q000166:cytology* / Q000378:metabolism; D008745:Methylation; D010713:Phosphatidylcholines / Q000096:biosynthesis*; D010714:Phosphatidylethanolamines / Q000378:metabolism*; D014372:Tubercidin / Q000494:pharmacology
D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; C018258:3-deazaadenosine; D014372:Tubercidin