[Effect of 1,2,4-triaminotriazole on Candida mycoderma catalase in substrate oxidation].
The effect of 1,2,4-triaminotriazole on the activity of catalase was studied in the resting cells of Candida mycoderma when they oxidized glucose, ethanol and other alcohols. The compound was shown to inhibit the activity of catalase in the cells when the endogenous substrate and glucose were oxidized, but it had no effect on its activity during the oxidation of alcohols (C1-C4). Catalase is supposed to be involved in the oxidation of lower alcohols forming a complex with them and thus preventing the inhibiting action of 1,2,4-triaminotriazole.
D000640:Amitrole / Q000031:analogs & derivatives / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000201:enzymology; D002374:Catalase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D000431:Ethanol / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D014230:Triazoles / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D014230:Triazoles; D000431:Ethanol; C035141:guanazine; D002374:Catalase; D005947:Glucose; D000640:Amitrole
Vliianie 1,2,4-triaminotriazola na katalazu Candida mycoderma pri okislenii nekotorykh substratov.