Corneal and lenticular opacities in mentally retarded young adults treated with thioridazine and chlorpromazine.
Of 18 mentally retarded institutionalized subjects who had received long-term, high-dose treatment primarily with thioridazine or chlorpromazine, 2 developed definite corneal and lenticular opacities and 2 had equivocal ocular changes. In view of this finding, the authors suggest that alternative treatment, including different neuroleptics, be considered with mentally retarded institutionalized subjects; when that is not possible, subjects should be given periodic evaluation, including annual slit-lamp examination.
D000293:Adolescent; D000328:Adult; D002386:Cataract / Q000139:chemically induced*; D002648:Child; D002746:Chlorpromazine / Q000009:adverse effects*; D003318:Corneal Opacity / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007326:Institutionalization; D008607:Intellectual Disability / Q000188:drug therapy*; D008297:Male; D013881:Thioridazine / Q000009:adverse effects*
D013881:Thioridazine; D002746:Chlorpromazine