Intensive treatment with haloperidol of treatment-resistant chronic schizophrenic patients.
The authors treated 11 treatment-resistant schizophrenic patients with steadily increasing doses of haloperidol to determine the therapeutic range of plasma concentrations in such patients. Six patients responded, usually within a few weeks of treatment and at doses of 50 mg/day or less; plasma concentrations ranged between 17 and 42 ng/ml. Five patients were unresponsive, despite treatment for 13-22 weeks, doses of haloperidol of 180-270 mg/day, and plasma concentrations of 51-225 ng/ml. Doses greater than 150 mg/day appear unnecessary, because lesser doses generally provide plasma concentrations of 20-50 ng/ml. Failure to respond within 2 months of reaching such doses or plasma concentrations augurs for continued lack of response.
D000328:Adult; D002908:Chronic Disease; D004334:Drug Administration Schedule; D006220:Haloperidol / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D012565:Schizophrenic Psychology
D006220:Haloperidol