Antitumor activity of 13-methyl-berberrubine derivatives.
The antitumor activity of several 13-alkyl-berberrubine and newly synthesized ester derivatives, using experimental tumors (S-180, NF sarcoma, Ehrlich carcinoma and L-1210) in mice was tested. For chemotherapeutic evaluation, the therapeutic indices and ratios were determined. Our present findings confirmed that in berberrubine derivatives, the 9-demethyl structure was essential for the manifestation of antitumor activity and demonstrated tht ester derivatives also exhibit a remarkable antitumor activity, and the 13-methyl derivatives of both berberrubine and palmatrubine alkaloids showed high antitumor activity.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use* / Q000633:toxicity; D001599:Berberine / Q000031:analogs & derivatives / Q000627:therapeutic use* / Q000633:toxicity; D001600:Berberine Alkaloids / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D005260:Female; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D012510:Sarcoma 180 / Q000188:drug therapy; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D001600:Berberine Alkaloids; D001599:Berberine; C036111:13-methylberberrubine