[Effect of heparin on postradiation thymus recovery in mice with various degrees of radiosensitivity].
BALB/c, random-bred and hybrid (CBA x C57Bl) F1 mice were exposed to a total single irradiation with CO60 gamma-rays (0.2 Gy/min) in doses of 4--6 Gy. Upon sublethal irradiation changes in the thymus mass were biphasic in nature. At the same time the degree of a secondary decrease in the thymus mass depended on radioresistance of the mice. On the 20th day after the irradiation the thymus mass in BALB/c mice (LD50/30 -- 6 Gy) reduced 3-fold, while that in mouse hybrids (LD50/30 -- 7 Gy) 2-fold. Upon heparin injection from day 5 to day 9 after the irradiation (250 units/kg once a day) the postradiation pattern of thymus mass recovery in radiosensitive BALB/c mice was similar to that seen in more resistant F1 hybrids.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D005720:Gamma Rays; D006493:Heparin / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009929:Organ Size / Q000187:drug effects / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D011836:Radiation Tolerance; D013950:Thymus Gland / Q000187:drug effects* / Q000528:radiation effects
D006493:Heparin
Vliianie geparina na postluchevoe vosstanovlenie timusa u mysheĭ s razlichnoĭ radiochuvstvitel'nost'iu.