[Coronary perfusion rate as a factor determining the degree of heart contractile function decrease in an energy formation disorder].
Experiments on the isolated hearts of guinea pigs have shown that administration of dinitrophenol in the concentrations of 0.01-0.10 mmol elicited, depending on the dose given, a decrease in pressure of a latex balloon, placed into the cavity of the left ventricle and an increase in the displacement of the SI segment on the ECG, recorded from the subendocardial layer of the apex. It is established that the rate of the coronary flow, limiting washing out of K+ and other metabolites determines the degree of depression of the contractile function with energy formation disorders and also its restoration during reoxygenation.
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D004140:Dinitrophenols / Q000494:pharmacology; D004562:Electrocardiography; D004734:Energy Metabolism / Q000187:drug effects; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D000860:Hypoxia / Q000378:metabolism; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D051381:Rats
D004140:Dinitrophenols; D011188:Potassium
Skorost' koronarnoĭ perfuzii kak faktor, opredeliaiushchiĭ stepen' umen'sheniia sokratitel'noĭ funktsii serdtsa pri narushenii énergoobrazovaniia.