Effects of synthetic pyrethroids on mammalian chromosomes. I. Sumicidin.
Sumicidin, a fenvalerate type of synthetic pyrethroid, is used as an alternative for classical insecticides. When force-fed in low doses daily over a long period (21 days) to Rattus norvegicus, in vivo, chromosomal aberrations and alterations in the mitotic index were induced. Its cumulative effect in vivo is both dose- and time-dependent and is more drastic on the spindle mechanism, possibly owing to progressive detoxication into more active compounds.
D000818:Animals; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects* / Q000502:physiology; D005260:Female; D007306:Insecticides / Q000494:pharmacology*; D008297:Male; D008940:Mitotic Index / Q000187:drug effects; D009153:Mutagens; D009154:Mutation; D009570:Nitriles; D011722:Pyrethrins / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats
D007306:Insecticides; D009153:Mutagens; D009570:Nitriles; D011722:Pyrethrins; C017690:fenvalerate