[Studies on fortimicin in the field of ophthalmology].
Bacteriological and clinical studies of fortimicin in the field of ophthalmology were performed and the results obtained were as follows. 1. The concentration of fortimicin in serum, primary aqueous humor and secondary aqueous humor after intramuscular injection of 30 mg/kg to rabbit reached the peak value of 23.36 microgram/ml after 1/2 hour, 6.07 microgram/ml after 1 hour and 60.6 microgram/ml after 1 hour, respectively. 2. The concentration of fortimicin in primary aqueous humor after subconjunctival injection of 10 mg (0.5 ml) in the rabbit eye reached the peak value of 8.06 microgram/ml after 1/2 hour. 3. The concentration of fortimicin in plasma and primary aqueous humor after intramuscular injection of 200 mg in patients of cataract before operation reached the value of 8.85 microgram/ml and 0.74 microgram/ml after 1 hour. 4. Fortimicin was administered to 5 cases of internal hordeolum and 2 cases of corneal ulcer. Clinical effects were excellent in 3 cases, good in 2 cases and fair in 2 cases. Side effect was observed diarrhea, but the causal relationship with fortimicin was unknown.
D000328:Adult; D000368:Aged; D000617:Aminoglycosides / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000627:therapeutic use*; D001082:Aqueous Humor / Q000378:metabolism; D003320:Corneal Ulcer / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D006726:Hordeolum / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011817:Rabbits
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C023521:fortimicins