Effect of vitamin B2 on tumorigenesis of 3-methylcholanthrene in the mouse skin.
Local administration of riboflavin 2',3',4',5'-tetrabutyrate (B2-But4) suppressed the induction of skin tumors in mice by 3-methylcholanthrene. The latent period for the appearance of tumors was markedly delayed in the group treated with B2-But4. These findings suggest that riboflavin might retard the process of skin tumorigenesis.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D008748:Methylcholanthrene; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control*; D012256:Riboflavin / Q000031:analogs & derivatives* / Q000494:pharmacology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
D008748:Methylcholanthrene; C009175:riboflavin tetrabutyrate; D012256:Riboflavin