Microencapsulation of erythrocytes.
Human erythrocytes have been encapsulated in a polyacrylate membrane by a simple precipitation process. The encapsulated cells appeared to remain functional after encapsulation: the consumption of glucose and the ability to reversibly bind oxygen was unimpaired. Furthermore, storage at 4 degrees C for almost 6 months had no effect on the P50 and n50 values. This is the first time to our knowledge that live mammalian cells have been encapsulated in a polymer other than alginate.
D000180:Acrylic Resins; D004912:Erythrocytes / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008567:Membranes, Artificial; D010101:Oxygen Consumption; D010539:Permeability; D011109:Polymethacrylic Acids; D014021:Tissue Preservation
D000180:Acrylic Resins; D008567:Membranes, Artificial; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; D005947:Glucose