The effect of beclomethasone diproprionate on bronchial hyperreactivity.
BDP is a useful treatment for asthma, but the mechanism of its action is unknown. Routine estimations of bronchial sensitivity to histamine aerosols showed that there was a decrease in bronchial hyperreactivity in 11 out of 14 cases given BDP as a routine treatment. The results are significant by Student's t-test (P less than .001) and reveal one mechanism by which BDP can act in the lungs.
D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000368:Aged; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy*; D001507:Beclomethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005541:Forced Expiratory Volume; D006632:Histamine; D006801:Humans; D008297:Male; D008875:Middle Aged; D012130:Respiratory Hypersensitivity / Q000188:drug therapy*
D000336:Aerosols; D006632:Histamine; D001507:Beclomethasone