[Properties and mechanism of hyperlipidemia induced in rabbits by tributyltin fluoride].
Male Japanese white rabbits were given tributyltin fluoride (TBTF) by gastric intubation with a single dose of 100 mg/kg body weight and their lipid and glucose metabolisms were investigated. After administration of TBTF, a reversible, but remarkable increase of lipids in plasma, particularly of triglycerides and total cholesterol, was observed. Ultracentrifugation of plasma lipoproteins revealed a marked increase in chylomicron+VLDL (very low density lipoprotein) fraction. Lipoprotein lipase (LPL) activity in postheparin plasma reduced significantly (p less than 0.02) to the levels of about 50% of the control. Fasting blood glucose level was elevated and a significant inhibition of insulin (IRI) release in response to the intravenous glucose infusion was observed in TBTF treated rabbits, but the level of blood glucose and the degree of inhibition of IRI release were low compared with those of triphenyltin fluoride treated rabbits, in which much greater fasting hyperglycemia was observed. Microscopic examination of pancreas, kidneys and thyroid gland did not reveal histological alterations contributing to the hyperlipidemia. These results suggest that hyperlipidemia induced in rabbits by tributyltin fluoride is due to decreased LPL activity. The decrease in LPL activity seems to be related to the inhibition of insulin release from islets by TBTF.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D006949:Hyperlipidemias / Q000097:blood / Q000139:chemically induced*; D008049:Lipase / Q000097:blood; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D011817:Rabbits; D014220:Trialkyltin Compounds / Q000633:toxicity*; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D008055:Lipids; D008074:Lipoproteins; D014220:Trialkyltin Compounds; D014280:Triglycerides; C011559:tributyltin; D008049:Lipase