QSAR in a series of muscarinic agents. Note IV. - New pyridine and furan derivatives.
Two new series of picolyl- and furfuryltrimethylammonium salts have been prepared and studied in order to support some hypotheses previously formulated in the study of the topology of the muscarinic receptor. The general picture of ligand interactions with receptor as seen with correlation analysis is discussed. The new quantitative structure-activity relationship is compared with those previously formulated and it is shown that biological data for new congeners are well predicted by a correlation equation published earlier.
D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010277:Parasympathomimetics / Q000138:chemical synthesis*; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D005663:Furans; D010277:Parasympathomimetics; D011725:Pyridines