Induction of metallothionein in the rat brain by copper implantation but not by cobalt implantation.
Following gel-filtration of cytosol prepared from copper-implanted rat brain there was a pronounced copper-containing, cadmium-binding peak with a relative elution volume similar to that of hepatic metallothionein (MT). No such peak was apparent in cytosol derived from cobalt- or glass-implanted brains. Spectral analysis of a purified protein from copper-implanted brain reveal a UV absorption spectrum characteristic of MT.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003035:Cobalt / Q000008:administration & dosage / Q000494:pharmacology*; D003300:Copper / Q000008:administration & dosage / Q000494:pharmacology*; D004343:Drug Implants; D008297:Male; D008667:Metalloproteins / Q000096:biosynthesis*; D008668:Metallothionein / Q000096:biosynthesis*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D004343:Drug Implants; D008667:Metalloproteins; D009419:Nerve Tissue Proteins; D003035:Cobalt; D003300:Copper; D008668:Metallothionein