The apoprotein B-independent hepatic uptake of chylomicron remnants.
Rat lymph chylomicrons were treated with Pronase resulting in particles completely devoid of surface apoproteins. On re-incubation with serum, the Pronase-treated chylomicrons re-acquired, by transfer from other lipoproteins, all apoproteins except apoprotein B, which is water-insoluble and non-transferable. When two groups of rats were injected with [3H]cholesterol-labelled control or Pronase-treated chylomicrons, radioactivity was incorporated into the liver of both groups at similar rates. It is concluded that the remnants of the control and Pronase-treated chylomicrons formed in the vascular space were recognized and taken up by liver cells by a process that does not require apoprotein B.
D000818:Animals; D001053:Apolipoproteins / Q000494:pharmacology*; D001055:Apolipoproteins B; D002914:Chylomicrons / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011402:Pronase / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D001053:Apolipoproteins; D001055:Apolipoproteins B; D002914:Chylomicrons; D011402:Pronase