Properties of dihydrofolate reductase from a methotrexate-resistant subline of human KB cells and comparison with enzyme from KB parent cells and mouse S180 AT/3000 cells.
D000818:Animals; D002460:Cell Line; D004351:Drug Resistance; D004591:Electrophoresis, Polyacrylamide Gel; D005493:Folic Acid Antagonists; D006801:Humans; D007525:Isoelectric Focusing; D007700:Kinetics; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice; D008970:Molecular Weight; D009374:Neoplasms, Experimental / Q000201:enzymology*; D012510:Sarcoma 180 / Q000201:enzymology*; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*
D005493:Folic Acid Antagonists; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate