Metabolic events in infants of diabetic mothers during first 24 hours after birth. III. Changes in plasma amino acids.
Plasma amino acid concentration (AAC) were studied in 31 diabetic mothers (10 of White class A, 10 of B-C and 11 of D-F) and their 32 infants during the first 24 hours after birth. Only minor differences between the 3 groups were found at birth and 2 hours, and none at 12 and 24 hours after birth. The individual AAC in umbilical vein plasma did not correlate with birthweight. All AAC except aspartic acid, asparagine, cystine and glutamic acid were higher in umbilical venous plasma than in maternal plasma. Umbilical venous-arterial differences of amino acids did not correlate with maternal or umbilical vein insulin concentrations except for threonine and valine. In general essential amino acids decreased after birth. In 8 infants with hypoglycemia and hyperinsulinism at 2 hours of age several plasma amino acids were lower than in the normoglycemic infants.
D000328:Adult; D000596:Amino Acids / Q000097:blood*; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000097:blood*; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood; D013997:Time Factors
D000596:Amino Acids