[Effect of the water-soluble antioxidant hydroxypyridine-6 on the intensity of lipid peroxidation in eye tissues in experimental ophthalmic herpes].
Lipid peroxidation (LPO) in eye tissues of rabbits with experimental herpetic keratitis was evaluated from the malonic dialdehyde content and chemiluminescence intensity. It appeared that during the critical phase LPO sharply increased in all the tissues under study and in anterior chamber humor. After administration of the synthetic water-soluble antioxidant, hydroxypyridine-6 the subconjunctival content of malonic dialdehyde and chemiluminescence intensity approached normal values accompanied by positive therapeutic effect.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005123:Eye / Q000187:drug effects* / Q000378:metabolism; D007635:Keratitis, Dendritic / Q000188:drug therapy* / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D011725:Pyridines / Q000627:therapeutic use*; D011817:Rabbits; D012995:Solubility
D000975:Antioxidants; D008054:Lipid Peroxides; D011725:Pyridines; C014047:hydroxypyridines
Vliianie vodorastvorimogo antioksidanta oksipiridina-6 na intensivnost' perekisnogo okisleniia lipidov v tkaniakh glaza pri éksperimental'nom oftal'mogerpese.