Rapid restoration of injured kidney after immediate removal of opposite normal kidney. In comparison with delayed contralateral nephrectomy.
The difference in restoration of injured kidneys according to the time of contralateral nephrectomy was investigated in rats. When the opposite normal kidney was removed immediately or when both kidneys were rendered ischemic totally, the function of the injured kidney or kidneys was rapidly restored and showed almost normal level of blood urea nitrogen as well as normal histology one week after the ischemic damage. But delayed contralateral nephrectomy slowed down the speed of recovery, and the injured kidney did not function completely and showed severe inflammatory reaction in histology four weeks after the injury. It was discussed that retention of some factors like renal hypertrophy factor would cause rapid restoration of the damaged kidney.
D000818:Animals; D001806:Blood Urea Nitrogen; D005260:Female; D007511:Ischemia / Q000473:pathology / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply / Q000473:pathology / Q000502:physiology*; D008297:Male; D009392:Nephrectomy / Q000379:methods*; D009395:Nephritis, Interstitial / Q000209:etiology / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors