[On the determination of chlorpropham, metobromuron and chlorbromuron residues in drugs of the 2. AB-DDR (author's transl)].
A method for analyzing drugs of the 2. AB-DDR for residues of chlorpropham, metobromuron and chlorbromuron is proposed. It is based on the detection of aniline derivatives resulting from alkaline hydrolysis. Herbicide concentrations greater than 0.25 mg/kg drug may be detected and semiquantitatively estimated by thin-layer chromatography. Smaller amounts of herbicide residues are detected gas chromatographically (using an electron attachment detector) after bromination of the hydrolysis products. The limits of detection are: chlorpropham, 0.006 mg/kg drug; chlorbromuron, 0.008 mg/kg drug; and metobromuron, 0.04 mg/kg drug. For impregnated drugs, the recovery rates lie between 82 and 102%. The herbicide residues are released to infusions at a varying extent, depending on the kinds of drugs used.
D002748:Chlorpropham / Q000032:analysis*; D002849:Chromatography, Gas / Q000379:methods; D004340:Drug Contamination / Q000032:analysis*; D005859:Germany, East; D006540:Herbicides / Q000032:analysis*; D008782:Methylurea Compounds / Q000032:analysis*; D010573:Pesticide Residues / Q000032:analysis*; D010602:Pharmacopoeias as Topic; D010671:Phenylurea Compounds / Q000032:analysis*
D006540:Herbicides; D008782:Methylurea Compounds; D010573:Pesticide Residues; D010671:Phenylurea Compounds; D002748:Chlorpropham; C014401:chlorbromuron; C008770:metobromuron
Zur Rückstandsanalytik von Chlorpropham, Metobromuron und Chlorbromuron in Drogen des Arzneibuches der DDR, 2. Ausgabe.