[Method of assessing the effect of preparations on the ulcerogenic action of reserpine in mice].
A method for intraperitoneal (2.5 mg/kg) or enteral (10 mg/kg) administration of reserpine to mice with subsequent keeping for 2 hours at a temperature of 7 degrees C and for 16 hours at a temperature maintained at the animal house has been suggested to induce lesions of the glandular part of the stomach. The lesions have been subjected to histological study. The influence of cooling, fasting and the animals' sex on the formation of lesions has been examined. It has been established by the method suggested that iproniazid almost completely prevents ulcerogenous action of reserpine, while atropine and ephedrine have pronounced protective properties. Of the flavonoids, quercetin has been found to manifest marked protective activity. It was more effective than hyperoxide or quercetin 3'-glucoside. Rutin has not averted lesions in the stomach. The method deserves attention since it enables one to evaluate antialterative activity of the minimal doses of the drugs with the different mechanism of action.
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012110:Reserpine / Q000494:pharmacology*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology
D000897:Anti-Ulcer Agents; D012110:Reserpine
Metod otsenki vliianiia preparatov na ul'tserogennoe deĭstvie rezerpina u mysheĭ.