Effect of tobramycin on serum pseudocholinesterase levels.
Tobramycin given in a single dose of 1 mg.Kg-1 intramuscularly, in healthy male volunteers, did not produce any significant change in serum pseudocholinesterase levels. The above antibiotic given in a single dose of 2 mg.Kg-1 intramuscularly produced a statistically significant increase (p less than 0.05) of serum pseudocholinesterase levels 2 and 4 hours after its administration. However, this increase is very small to have any clinical significance. For the anaesthesiologist, a decrease, rather than an increase, of the serum pseudocholinesterase level should be of clinical significance.
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002091:Butyrylcholinesterase / Q000097:blood*; D002802:Cholinesterases / Q000097:blood*; D006801:Humans; D008297:Male; D013997:Time Factors; D014031:Tobramycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D002091:Butyrylcholinesterase; D002802:Cholinesterases; D014031:Tobramycin