In vitro activity of the two principal oxidative metabolites of metronidazole against Bacteroides fragilis and related species.
Metronidazole and its two principal oxidative metabolites were tested in vitro against 20 clinical isolates of the Bacteroides fragilis group. Both metabolites were bactericidal, and the exhibited 65 and 5%, respectively, of the inhibitory effect of metronidazole. Additive or weak synergistic effects resulted in combination with the parent compound.
D001441:Bacteroides fragilis / Q000187:drug effects*; D004347:Drug Interactions; D007700:Kinetics; D008795:Metronidazole / Q000378:metabolism / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010084:Oxidation-Reduction
D008795:Metronidazole