[New data on the mechanisms of glucose transport in the small intestine based on an analysis of the role of serous-mucous flows].
The transport of glucose, other monosaccharides and disaccharides in the rat small intestine has been studied under the condition of a predominance of serosal-to-mucosal (SM) flows over mucosal-to-serosal (MS) ones. A dependence has been found of the efflux of glucose into the serosal solution on the duration of incubation, starting glucose concentration in the serosal solution, intestinal segment under study (proximal-distal gradient), action of glucose transport inhibitors (phlorizin, absence of Na+ in the incubation medium, anoxia) and temperature. In this paper, the hypothesis on entero-hematic circulation has been proposed, according to which recycling of glucose is one of the important manifestations of processes of microcirculation of substances between blood and the intestine.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000378:metabolism*; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012704:Serous Membrane / Q000378:metabolism; D013696:Temperature
D005947:Glucose
Novye dannye o mekhanizmakh transporta gliukozy v tonkoĭ kishke, osnovannye na analize roli serozno-mukoznykh potokov.