An analysis of piroxicam in rodent models of arthritis.
Piroxicam, a potent, long acting non-steroidal anti-inflammatory drug, was tested in several rodent models of arthritis to assess further the possible mechanisms underlying its anti-inflammatory action. Piroxicam inhibited rat adjuvant disease and its associated manifestations, which include erosion of bone and cartilage (as evidenced by X-ray examination), soft tissue swelling and disease-induced weight loss. Piroxicam also inhibited the edema, the total leukocyte infiltration and the mononuclear cell infiltration into the carrageenan-injected pleural cavity of the rat. The possible relationship of these effects to the clinical activity of piroxicam is discussed.
D000818:Animals; D000893:Anti-Inflammatory Agents; D001169:Arthritis, Experimental / Q000188:drug therapy; D001847:Bone Diseases / Q000188:drug therapy; D002465:Cell Movement / Q000187:drug effects; D005122:Exudates and Transudates / Q000166:cytology; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D010894:Piroxicam; D010994:Pleura / Q000166:cytology; D011833:Radiation Injuries, Experimental / Q000188:drug therapy; D051381:Rats; D013843:Thiazines / Q000494:pharmacology*; D013997:Time Factors; D014965:X-Rays
D000893:Anti-Inflammatory Agents; D013843:Thiazines; D010894:Piroxicam