Ulcerating enteritis associated with flucytosine therapy.
Flucytosine-associated diarrhea has been previously described in 6%-10% of patients receiving the drug. A potentially fatal ulcerating enterocolitis has been reported in 4 patients. In none of these reports has radiologic or pathologic data been presented. This report describes a case of flucytosine-associated ulcerating enteritis in which the small bowel x-ray demonstrated severe luminal narrowing, ulceration, and marked separation of loops of bowel. Ileal biopsy revealed an erosive enteritis with mucosal inflammatory infiltrate and disruption of the surface epithelium. Discontinuation of the drug resulted in total resolution of the clinical and radiologic abnormalities.
D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D001706:Biopsy; D003453:Cryptococcosis / Q000188:drug therapy; D003596:Cytosine / Q000031:analogs & derivatives*; D003967:Diarrhea / Q000139:chemically induced; D005437:Flucytosine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007079:Ileitis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D007082:Ileum / Q000473:pathology; D008297:Male; D011859:Radiography; D014456:Ulcer / Q000139:chemically induced
D000666:Amphotericin B; D003596:Cytosine; D005437:Flucytosine