Chemistry of carbamoyl disulfide protected derivatives of proline.
High-yield methods have been devised for the synthesis of a series of alkyl and aryldithiocarbonyl derivatives of the alpha-imino acid proline. The carbamoyl disulfide protecting groups were rapidly and quantitatively removed under a variety of reductive conditions, suggesting their potential value for orthogonal schemes of peptide synthesis.
D002219:Carbamates; D055598:Chemical Phenomena; D002621:Chemistry; D004220:Disulfides; D007202:Indicators and Reagents; D011392:Proline / Q000031:analogs & derivatives*; D013329:Structure-Activity Relationship
D002219:Carbamates; D004220:Disulfides; D007202:Indicators and Reagents; D011392:Proline