Effect of age and cholestyramine feeding on rat liver 3-hydroxy-3-methyl glutaryl CoA reductase, sterol carrier protein 1 and sterol carrier protein 2 activities.
The rate of formation of sterol from squalene in livers from suckling rats was less than one-third that of adults. This difference was due to a lesser activity of microsomal enzymes in the suckling rat livers, and not to any difference in cytosolic sterol carrier protein 1. The microsomal enzymes and sterol carrier protein 2 of the cytosol required for the conversion 7-dehydrocholesterol to cholesterol were both lower in suckling rats compared to adults. Both those activities paralleled the differences in HMG-CoA reductase activities between suckling and adult rats. Feeding of cholestryamine to adult rats increased the activities of the microsomal enzymes, sterol carrier protein 1 and sterol carrier protein 2 involved in the conversion of squalene to cholesterol.
D000284:Administration, Oral; D000375:Aging; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002792:Cholestyramine Resin / Q000008:administration & dosage / Q000494:pharmacology*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D010940:Plant Proteins; D051381:Rats; D011919:Rats, Inbred Strains; D013185:Squalene / Q000378:metabolism
D002352:Carrier Proteins; D010940:Plant Proteins; C072087:sterol carrier proteins; D002792:Cholestyramine Resin; D013185:Squalene; D006903:Hydroxymethylglutaryl CoA Reductases