Pharmacokinetic study of torasemide in humans: an overview of its diuretic effect.
A new diuretic drug, torasemide, after oral or i. v. administration of 20 mg to six normal volunteers showed good bioavailability (greater than 91%). Its biologic half-life is about 2.5 h with a distribution volume of 180 ml/kg and a body clearance of 0.8 ml/min kg. The renal excretion represents only 25% of the total drug elimination. The excretion of water, sodium, potassium, and chloride parallels the renal excretion of torasemide. The diuretic action has a duration of 6 h, reaching its maxima during the 1st h after i. v. administration an during the 2nd h after oral administration.
D000284:Administration, Oral; D000328:Adult; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000378:metabolism*; D004573:Electrolytes / Q000097:blood; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D012965:Sodium Chloride / Q000378:metabolism; D013449:Sulfonamides / Q000378:metabolism* / Q000494:pharmacology; D013997:Time Factors; D000077786:Torsemide
D004232:Diuretics; D004573:Electrolytes; D013449:Sulfonamides; D012965:Sodium Chloride; D000077786:Torsemide