The role of antibodies and serum complement in the interaction between macrophages and leptospires.
Guinea-pig macrophages exerted bactericidal activity against both a virulent and a saprophytic strain of leptospira in the presence of the homologous IgG. Serum complement alone rendered the saprophytic strain susceptible to phagocytosis by the same macrophages.
D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology*; D001433:Bacteriolysis; D003165:Complement System Proteins / Q000276:immunology*; D006168:Guinea Pigs; D007074:Immunoglobulin G / Q000276:immunology*; D007919:Leptospira / Q000276:immunology* / Q000648:ultrastructure; D008264:Macrophages / Q000276:immunology*; D008854:Microscopy, Electron; D009895:Opsonin Proteins; D010587:Phagocytosis
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D009895:Opsonin Proteins; D003165:Complement System Proteins