Mania secondary to procyclidine ("Kemadrin") abuse.
A case of procyclidine abuse is described in which the clinical presentation was indistinguishable from mania. The patient was a long-standing poly-drug abuser and was obtaining the drugs from medical sources. Controlled exposure on the ward to drugs of abuse, including a double-blind comparison with placebo, confirmed that procyclidine caused a manic response in this patient.
D000328:Adult; D000341:Affective Disorders, Psychotic / Q000139:chemically induced*; D001714:Bipolar Disorder / Q000139:chemically induced*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D011352:Procyclidine; D011759:Pyrrolidines; D019966:Substance-Related Disorders
D011759:Pyrrolidines; D011352:Procyclidine