[Studies in mice on diminishing acute toxicity of violamycin BI by combined therapy (author's transl)].
In mice the effect of L-ascorbic acid (i.p., drink. wat.), DL-carnitine (i.p., drink. wat.), L-cysteine (i.p., drink. wat.), DL-methionine (i.p., drink. wat.), folic acid plus ascorbic acid (i.v.), and alpha-tocopherol (i.p.), respectively, on sublethal and lethal i.v. doses of the anthracycline antibiotic violamycin BI (VBI) was tested. The VBI induced lethality (%) of the animals was found to be unaffected by combined treatment with the drugs used. Only a delayed toxicity following alpha-tocopherol administration was observed.
D000617:Aminoglycosides / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents; D001205:Ascorbic Acid / Q000494:pharmacology; D002331:Carnitine / Q000494:pharmacology; D003545:Cysteine / Q000494:pharmacology; D004285:Dogs; D004347:Drug Interactions; D005260:Female; D005492:Folic Acid / Q000494:pharmacology; D008297:Male; D008715:Methionine / Q000494:pharmacology; D051379:Mice; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013552:Swine; D014810:Vitamin E / Q000494:pharmacology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D014810:Vitamin E; C022171:violamycin BI; D005492:Folic Acid; D008715:Methionine; D003545:Cysteine; D001205:Ascorbic Acid; D002331:Carnitine
Untersuchungen an der Maus zur Herabsetzung der akuten Toxizität von Violamycin BI durch Kombinationsbehandlung.