Electrophysiology of the normal-to-hypoxic transition zone.
The "normal-to-hypoxic" transition zone was modeled after the chamber technique for perpendicular and parallel orientation with respect to the direction of fiber axis. The evidence obtained from the recording of the transmembrane action potentials suggests the presence of a preservation phenomenon in the hypoxic area, based on the utilization of energy stores of the normoxic area. Better intercellular coupling in longitudinal than in transverse fiber direction results in the anisotropic properties of the preservation phenomenon. The preservation phenomenon provides a basis for the existence of critical size of the viable hypoxic area compared to the size of the transitional zone. The crucial role of electrotonic coupling was demonstrated, as well as the possible contribution to the preservation phenomenon mechanism of the cell-to-cell diffusion of metabolites.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002450:Cell Communication / Q000187:drug effects; D004195:Disease Models, Animal; D004594:Electrophysiology / Q000379:methods; D006325:Heart Atria / Q000503:physiopathology; D006835:Hydrazones / Q000494:pharmacology; D000860:Hypoxia / Q000503:physiopathology*; D008954:Models, Biological; D011817:Rabbits
D006835:Hydrazones; C012483:phenylhydrazone