Selective reduction of one class of dopamine receptor binding sites in the corpus striatum of aged rats.
In aged rats (21-23 vs 3 month) the neuroleptic receptor number was reduced in the striatum (--53%), in the limbic area (--36%), and not changed in the cortex. The in vitro pharmacological profile of the remaining [3H]spiroperidol receptors in each area was not modified in aged animals. The binding of [3H]ADTN (2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronapthalene) in the striatum and of [3H]serotonin ([3H]-5 HT) in the cortex was also the same in both age groups.
D000375:Aging; D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000254:growth & development / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D003342:Corpus Striatum / Q000254:growth & development* / Q000378:metabolism; D005456:Fluorescent Dyes / Q000378:metabolism; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D013134:Spiperone / Q000378:metabolism; D013764:Tetrahydronaphthalenes / Q000378:metabolism; D014018:Tissue Distribution
D005456:Fluorescent Dyes; D011954:Receptors, Dopamine; D013764:Tetrahydronaphthalenes; D012701:Serotonin; D013134:Spiperone; C011639:ADTN