Chelation in metal intoxication. XII. Antidotal efficacy of chelating agents on acute toxicity of manganese.
Several structurally different metal chelating agents were screened for their relative efficacy in counteracting acute manganese intoxication in mice. Polyaminocarboxylic acids with nitrogen and oxygen as metal binding sites were more effective than certain sulfhydryl chelating agents and common drugs in preventing mortality due to a lethal dose of manganese chloride. However, a few common drugs which could be used in high dosage or for longer duration in manganese intoxication without serious side effects, appear promising.
D000818:Animals; D000931:Antidotes; D002614:Chelating Agents / Q000494:pharmacology*; D005260:Female; D008345:Manganese / Q000037:antagonists & inhibitors*; D020149:Manganese Poisoning; D051379:Mice; D013438:Sulfhydryl Compounds / Q000494:pharmacology
D000931:Antidotes; D002614:Chelating Agents; D013438:Sulfhydryl Compounds; D008345:Manganese