[Mechanism of the species characteristics of the sensitivity of monkeys and dogs to the emetic action of various pharmacological agents].
Monkey and dog sensitivity to the emetics that stimulate catecholamino- and serotoninoreactive structures of the chemoreceptor trigger zone (CTZ) of the vomiting center has been studied. It has been found that the monkeys are sensitive to the vomiting effect of serotonin agonists, while the dogs to the stimulants of the dopamino- and adrenoreceptors of the CTZ. At the same time both the monkeys and dogs are equally sensitive to the emetic action of sodium salicylate. The latter's effect has been shown to be realized via the serotoninergic structures of the CTZ in the monkeys, and via the adrenergic structures in the dogs. It is suggested that specific features of the monkey and dog responses to administration of central emetics are determined by the differences in the neurochemical structure of the CTZ, particularly by the prevalence of the serotonin- or catecholamine-containing neurons.
D000818:Animals; D004285:Dogs; D004639:Emetics / Q000494:pharmacology*; D005260:Female; D008253:Macaca mulatta; D008297:Male; D011941:Receptors, Adrenergic / Q000187:drug effects; D011954:Receptors, Dopamine / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D012980:Sodium Salicylate / Q000037:antagonists & inhibitors / Q000494:pharmacology; D013045:Species Specificity
D004639:Emetics; D011941:Receptors, Adrenergic; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012980:Sodium Salicylate
K mekhanizmu vidovykh osobennosteĭ chuvstvitel'nosti obez'ian i sobak k émeticheskomu deĭstviiu razlichnykh farmakologicheskikh sredstv.