N-Alkylated derivatives of 5-fluorouracil.
Some N-alkyl derivatives of 5-fluorouracil were designed to act as latent depot forms of 5-fluorouracil. A general and efficient method for the syntheses of the alkylated derivatives is described. As expected, the alkylated derivatives of 5-fluorouracil did not show any cytotoxicity in cell culture systems even up to 10(-4) M concentration. The synthesis of 1,3-dimethyl-5-fluoro-5,6-dihydrouracil is also described.
D000478:Alkylation; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D013056:Spectrophotometry, Ultraviolet
D000970:Antineoplastic Agents; D005472:Fluorouracil