Mechanism of inhibition of microsomal drug metabolism by imidazole.
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000037:antagonists & inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D007093:Imidazoles / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors*; D009575:Nitroanisole O-Demethylase / Q000037:antagonists & inhibitors; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D010089:Oxidoreductases, N-Demethylating / Q000037:antagonists & inhibitors; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011817:Rabbits; D013053:Spectrophotometry
D007093:Imidazoles; D004364:Pharmaceutical Preparations; C029899:imidazole; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D009575:Nitroanisole O-Demethylase; D010088:Oxidoreductases; D001189:Aryl Hydrocarbon Hydroxylases; C023738:acetanilide hydroxylase; C020065:N,N-dimethylaniline demethylase; D010089:Oxidoreductases, N-Demethylating