The metabolism of 4-(4-hydroxyphenyl)butan-2-one (raspberry ketone) in rats, guinea-pigs and rabbits.
1. The metabolism of 4-(4-hydroxyphenyl)butan-2-one(raspberry ketone) was studied in rats, guinea-pigs and rabbits. 2. Following intragastric dosage (1 mmol/kg) urinary metabolite excretion was nearly complete within 24 h, amounting to roughly 90% of the dose in all species. 3. The most prominent urinary metabolites were raspberry ketone and its corresponding carbinol, both largely conjugated with glucuronic acid and/or sulphate. The extent of ketone reduction was greatest in rabbits. 4. Oxidative metabolism included ring hydroxylation and side-chain oxidation. The latter pathway led to 1,2- and 2,3-diol derivatives. It is proposed that the latter undergo cleavage to furnish the C6-C3 and C6-C2 derivatives detected.
D000818:Animals; D001646:Bile / Q000378:metabolism; D002074:Butanones / Q000378:metabolism* / Q000652:urine; D002432:Cecum / Q000378:metabolism / Q000382:microbiology; D005421:Flavoring Agents / Q000378:metabolism* / Q000652:urine; D006168:Guinea Pigs; D008297:Male; D010084:Oxidation-Reduction; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D002074:Butanones; D005421:Flavoring Agents; C035522:raspberry ketone