[Respiration of multi-injured patients with He-O2 and N2-O2 mixtures. I. Ventilatory effects and pulmonary gas exchange].
Polytraumatic patients (n = 19), requiring for ventilatory support [8, 23, 24], were alternatively normoventilated (PaCO2 approximately equal to 40 mm Hg) with either He-O2 or N2-O2 (FIO2 = 0,3) using positive endexspiratory pressures of 0, 5, 10 and 15 cm H2O. The results demonstrated that the tidal volume decreased by 17% during the ventilation with He-O2 as compared with N2-O2. At the same time the inspiratory resistance and the inspiratory peak-pressure decreased by 20%. These results can be explained by the physical properties of helium, since helium guarantees a laminar flow during respiration in contrast to N2 even in obstructive airways. In conclusion it can be said that polytrauma patients have a inhomogeneous distribution of ventilation starting at the day of accident, that leads to a rise in deadspace ventilation. Because of having lower respiration pressures by using He-O2 mixtures, pulmonary barotrauma could be reduced.
D000328:Adult; D000399:Air Pressure; D000403:Airway Resistance; D001784:Blood Gas Analysis; D005260:Female; D006371:Helium; D006801:Humans; D008297:Male; D009584:Nitrogen; D010100:Oxygen; D012121:Respiration, Artificial / Q000379:methods*; D012129:Respiratory Function Tests; D014947:Wounds and Injuries / Q000503:physiopathology / Q000628:therapy*
D006371:Helium; D009584:Nitrogen; D010100:Oxygen
Die Beatmung polytraumatisierter Patienten mit He-O2-und N2-O2-Gemischen. I. Atemmechanik und pulmonaler Gasaustausch.