Aluminum associated bone disease: clinico-pathologic correlation.
A chemical, aurine tricarboxylic acid was used to identify aluminum in bone in a group of chronic renal failure patients with severe osteomalacia. Thirteen out of 49 (26%) patients had a positive stain at the bone-osteoid junction. The presence of aluminum at the staining site was confirmed by electron dispersion x-ray analysis. The patients' biopsies staining negative with this clinical, although having high bone aluminum levels, had more significant features of hyperparathyroidism, both biochemically and histologically than those having a positive stain. The usefulness of this technique to diagnose presymptomatic aluminum related osteomalacia is emphasized.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000535:Aluminum / Q000009:adverse effects* / Q000032:analysis; D001842:Bone and Bones / Q000032:analysis; D002118:Calcium / Q000032:analysis; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010018:Osteomalacia / Q000139:chemically induced; D006435:Renal Dialysis / Q000009:adverse effects
D000535:Aluminum; D002118:Calcium