[Role of ATP in regulating the oxoglutarate dehydrogenase complex of the adrenal cortex].
At unsaturating concentration of 2-oxoglutarate, ATP markedly inhibited the adrenal oxoglutarate dehydrogenase complex activity due to chelation of magnesium ions required for activity of the enzyme. At the same time, ATP opposed competitively the activating influence of a positive effector ADP.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000302:Adrenal Cortex / Q000201:enzymology*; D000818:Animals; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D007655:Ketoglutarate Dehydrogenase Complex / Q000037:antagonists & inhibitors*; D007658:Ketone Oxidoreductases / Q000037:antagonists & inhibitors*; D007700:Kinetics; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D008928:Mitochondria / Q000201:enzymology
D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D007658:Ketone Oxidoreductases; D007655:Ketoglutarate Dehydrogenase Complex; D008274:Magnesium
O roli ATF v reguliatsii oksoglutaratdegidrogenaznogo kompleksa kory nadpochechnikov.