Bioavailability of methotrexate tablets.
The bioavailability of methotrexate 10 mg tablets has been determined to be 62 +/- 16%. After administration of a dose of 30 mg/m2 a maximum plasma concentration of ca. 20.10(-7) mole/l was found after ca. 1.7 h. The methotrexate plasma half-life was 2.4 h. It was concluded that the 10 mg tablet formulation at the dosage investigated is a suitable clinical methotrexate preparation.
D000284:Administration, Oral; D000368:Aged; D001682:Biological Availability; D001943:Breast Neoplasms / Q000188:drug therapy; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008727:Methotrexate / Q000008:administration & dosage* / Q000378:metabolism; D008875:Middle Aged; D013607:Tablets
D013607:Tablets; D008727:Methotrexate