[Biological action of nitrosodimethylamine studied in different in vivo and in vitro experimental models].
The biological effects of nitrosodimethylamine were studied and compared with the use of biochemical and cytological research methods in different laboratory models. Experiments were made with male and pregnant rats exposed to nitrosodimethylamine in vivo whereupon use was made of embryonic musculocutaneous tissue cell culture in vitro. The same line of changes seen in the activity of lysosomal hydrolases in conjunction with cytochromes P450 and b5 induction in liver chromosomes attests to the existence of common regularities in the biochemical mechanisms of nitrosodimethylamine detoxication in which there participate the endoplasmatic network and lysosomes.
D000818:Animals; D002478:Cells, Cultured; D004128:Dimethylnitrosamine / Q000633:toxicity*; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D011247:Pregnancy; D051381:Rats; D013997:Time Factors
D004128:Dimethylnitrosamine
Izuchenie biologicheskogo deĭstviia nitrozodimetilamina na razlichnykh éksperimental'nykh modeliakh in vivo i in vitro.