A comparative longitudinal study on sex hormone binding globulin capacity during estrogen replacement therapy.
An aqueous two-phase equilibrium partition system was used to assay SHBG-binding capacity. Sera from groups of postmenopausal women before and during unopposed estrogen replacement therapy were analyzed. The induction of SHBG showed considerable differences between different estrogens. Ethinyl-estradiol in a daily dose of 0.05 mg gave a 70% increase in the serum concentration of this liver derived protein. Estradiol-17 beta, 2 mg daily and estrone sulphate 1.25 mg gave moderate changes, whereas estriol in different doses had no effect. SHBG induction may reflect estrogen overtreatment.
D004958:Estradiol / Q000378:metabolism; D004964:Estriol / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism* / Q000627:therapeutic use; D004970:Estrone / Q000031:analogs & derivatives / Q000378:metabolism; D004997:Ethinyl Estradiol / Q000378:metabolism; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008593:Menopause / Q000187:drug effects; D008875:Middle Aged; D012712:Serum Globulins / Q000378:metabolism*
D004967:Estrogens; D012712:Serum Globulins; D004970:Estrone; D004997:Ethinyl Estradiol; D004958:Estradiol; D004964:Estriol; C017296:estrone sulfate