The measurement of serum 5-fluorocytosine levels in the presence of miconazole.
Miconazole is effective against a wide variety of fungi, and may be of value when used in combination with 5-fluorocytosine in the treatment of life-threatening mycotic infections. Because the hematologic toxicity of 5-fluorocytosine is related to high serum levels, the effects of miconazole on the standard disc diffusion assay for 5-fluorocytosine were studied. When standards were made in either undiluted or 10% pooled human serum, no difference in zone size between 5-fluorocytosine alone and the combination of 5-fluorocytosine and miconazole was found. It is concluded that, in this assay system, miconazole does not affect the disc diffusion test for serum 5-fluorocytosine levels.
D003596:Cytosine / Q000031:analogs & derivatives*; D004359:Drug Therapy, Combination; D005437:Flucytosine / Q000008:administration & dosage / Q000097:blood*; D006801:Humans; D007093:Imidazoles / Q000097:blood*; D008825:Miconazole / Q000008:administration & dosage / Q000097:blood*; D009181:Mycoses / Q000188:drug therapy
D007093:Imidazoles; D008825:Miconazole; D003596:Cytosine; D005437:Flucytosine