[Glutamate decarboxylase activity in subcellular fractions of tissues of brain visual analyzer in dogs during postnatal ontogenesis].
Fractions of mitochondria, synaptosomes and fragments of membranes isolated from structures of dog brain visual analyzer in the postnatal ontogenesis period differs in the glutamate decarboxylase activity. Till the 45th day of development it rises, as a rule, in all the fractions under study and then it lowers. An increase in the activity in most cases is more pronounced in subfractions of heavy synaptosomes and fragments membrane. The enzyme activity in the visual cortex (field 17), anterior corpora bigemina and external geniculate body rises differently. In one-day animals GABA is formed in the fraction of heavy synaptosomes of anterior corpora bigemina and external geniculate body with a higher intensity than in the visual cortex area (field 17) that may be associated with earlier GABA accumulation in GABA-ergic neurons of subcortical structures of the visual analyzer than in its cortical structures.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000201:enzymology / Q000254:growth & development*; D002262:Carboxy-Lyases / Q000378:metabolism*; D004285:Dogs; D005829:Geniculate Bodies / Q000254:growth & development; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D008928:Mitochondria / Q000201:enzymology*; D009474:Neurons / Q000201:enzymology; D009928:Organ Specificity; D013347:Subcellular Fractions / Q000201:enzymology; D013574:Synaptosomes / Q000201:enzymology*; D014793:Visual Cortex / Q000254:growth & development; D014796:Visual Perception
D002262:Carboxy-Lyases; D005968:Glutamate Decarboxylase
Aktivnost' glutamatdekarboksilazy v subkletochnykh fraktsiiakh tkaneĭ ritel'nogo analizatora mozga sobak v postnatal'nom ontogeneze.