The acute effects of ethanol on acetanilide disposition in normal subjects, and in patients with liver disease.
1 The effects of single doses (25 g and 50 g) oral ethanol on the disposition of acetanilide (50 mg/kg metabolic active mass) has been studied in normal subjects, and in patients with chronic non-alcoholic liver disease. 2 In normal subjects, ethanol produced a dose-dependent increase in acetanilide half-life, and a decrease in acetenilide clearance. There was a significant correlation (rs = 0.71, P less than 0.01) between the 90 min blood ethanol concentration and the reduction in acetanilide clearance. 3 In patients with liver disease, ethanol produced a similar proportional change in acetanilide half-life and clearance, but these were less consistent. Moreover, liver disease itself was associated with an increase in acetenilide half-life, and a reduction in clearance. 4 It is concluded that single oral doses of ethanol, comparable to those consumed during social drinking, may inhibit some forms of microsomal oxidation and thus have important clinical implications.
D000083:Acetanilides / Q000378:metabolism*; D000328:Adult; D000431:Ethanol / Q000378:metabolism / Q000494:pharmacology*; D006207:Half-Life; D006801:Humans; D008107:Liver Diseases / Q000378:metabolism*; D008875:Middle Aged; D010084:Oxidation-Reduction
D000083:Acetanilides; D000431:Ethanol