Genetic counselling in holoprosencephaly.
According to the etiological factors the various possibilities of genetic counselling in holoprosencephaly are discussed. In each type of holoprosencephaly a chromosomal analysis is indispensable. Prenatal chromosomal examination of subsequent pregnancies is indicated when dealing with a chromosomal aberration. Fetoscopy is useful under certain conditions. In addition, because of possibly associated neural tube defects, alpha 1-fetoprotein should be determined.
D000015:Abnormalities, Multiple / Q000235:genetics; D001921:Brain / Q000002:abnormalities*; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002901:Chromosomes, Human, 13-15; D004200:Diseases in Twins; D005260:Female; D005799:Genes, Dominant; D005817:Genetic Counseling; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014314:Trisomy