Dobutamine and cardiac oxygen balance in patients following myocardial revascularization.
Dobutamine is frequently used in the early postoperative period following myocardial revascularization to improve cardiac output. Seven postoperative adult patients with low output syndrome were studied before and during intravenous dobutamine (mean +/- SD: 5.1 +/- 2.5 micrograms/kg/min) infusion. The metabolic effects were evaluated and related to hemodynamic changes. Cardiac index increased 40% (p less than 0.05) with an increase in heart rate (p less than 0.05) and decreases in systemic vascular resistance and right atrial pressure (p less than 0.05). No significant changes occurred in arterial or pulmonary capillary wedge pressures or in stroke volume index. Dobutamine produced a 29% increased in myocardial oxygen consumption which, in these revascularized patients, was accompanied by a 35% increase in coronary blood flow. No significant alteration was observed in coronary sinus oxygen content or in global myocardial lactate extraction. Thus, despite the increased metabolic cost of dobutamine, global myocardial ischemia was not observed.
D001794:Blood Pressure / Q000187:drug effects; D006348:Cardiac Surgical Procedures; D002395:Catecholamines / Q000627:therapeutic use*; D003331:Coronary Vessels / Q000601:surgery*; D004280:Dobutamine / Q000627:therapeutic use*; D005260:Female; D006321:Heart / Q000187:drug effects / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D002395:Catecholamines; D004280:Dobutamine