[Pharmacokinetics of hydrazine sulfate in intact and tumor-bearing rats].
The pharmacokinetics of hydrazine sulfate was studied in intact and tumor-bearing (sarcoma 45) random-bred rats after intraventricular administration of the drug. To determine hydrazine in biosubstrates, a method was devised, which is based on spectrophotometry of the coloured product formed as a result of interaction with p-dimethylaminobenzaldehyde. Analysis of the pharmacokinetic data with the use of a 4-compartmental model showed appreciable differences in some of the pharmacokinetic parameters of hydrazine sulfate as regards intact and tumor-bearing animals.
D000818:Animals; D006834:Hydrazines / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D012513:Sarcoma, Experimental / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution
D006834:Hydrazines; C029424:hydrazine
Farmakokinetika gidrazinsul'fata u intaktnykh i opukholevykh krys.