[Age-specific peculiarities of the acid base balance and the influence of various diets].
The acid-base balance was studied in animals (486 male white rats) belonging to two age groups, one young (4 to 5 months) and the other old (24 to 28 months), as was the influence exercised by various diets. With growing age we found a rising trend towards a decrease in blood pH and a statistically significant increase in PCO2 in association with an insignificant decrease in the parameters for the system's metabolic element. Functional tests carried out by adding acidifying or alkalizing substances showed a declining reliability of the organism's puffer systems and a deminished reserve capacity of the regulatory mechanisms of the acid-base balance with growing age. We found that various nutrients (fats, proteins and carbohydrates) have a different impact on the acid-base balance in animals of various ages. While animals fats and proteins produce metabolic acidosis, carbohydrates produce metabolic alkalosis. We discovered some of the mechanisms responsible for the changes observed in the acid-base balance of both young and old animals. Our experiments showed light on the close relationship existing between the acid-base balance and the character and the nature of nutrients, thus convincingly demonstrating the possibility of active alimentary control of the organism's internal state.
D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000209:etiology; D000367:Age Factors; D000471:Alkalosis / Q000209:etiology; D000818:Animals; D004032:Diet / Q000009:adverse effects*; D004040:Dietary Carbohydrates / Q000009:adverse effects; D004041:Dietary Fats / Q000009:adverse effects; D008297:Male; D051381:Rats
D004040:Dietary Carbohydrates; D004041:Dietary Fats
Alternsspezifische Besonderheiten des Säuren-Basen-Gleichgewichts und seine Beeinflussung durch verschiedene alimentäre Einwirkungen.