Leprosy downgrading reaction associated with griseofulvin.
A dramatic alteration from clinically subpolar tuberculoid leprosy toward subpolar lepromatous leprosy was observed during griseofulvin therapy in a 29-year-old man, despite apparently normal cell-mediated immunity. To our knowledge, this is the first reported case of a downgrading reaction associated with griseofulvin. It is possible that this reaction was due to inhibition of polymorphonuclear leukocyte chemotaxis by griseofulvin.
D000328:Adult; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D006118:Griseofulvin / Q000009:adverse effects*; D006801:Humans; D007918:Leprosy / Q000209:etiology* / Q000276:immunology; D008297:Male
D006118:Griseofulvin