Platelet serotonin uptake and migraine.
Platelet serotonin uptake characteristics (Km, Vmax, y) were determined in platelet-rich plasma for 11 common migraineurs and 15 health volunteers. All three parameters were decreased only for the three patients having a migraine attack during blood collection, Migrainous platelets isolated on dextran or resuspended in control plasma exhibited normal serotonin uptake. This finding suggests that plasmatic factor(s) may be responsible for the decrease of platelet serotonin uptake observed during migraine attacks.
D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000097:blood*; D012701:Serotonin / Q000097:blood*
D012701:Serotonin