Implications from studies of the nucleus accumbens: toward a multi-factor theory of schizophrenia.
A model is propose of dopamine and histamine modulation of afferent hippocampal activity in the nucleus accumbens. It is suggested that increased dopamine action leads to an increase in the signal/noise ratio or a form of contrast enhancement. To the contrary, the effect of an increased histamine action would be to inhibit the most salient incoming hippocampal message; i.e., a form of contrast reduction.
D004298:Dopamine / Q000502:physiology; D006624:Hippocampus / Q000502:physiology; D006632:Histamine / Q000502:physiology; D006801:Humans; D008959:Models, Neurological; D009714:Nucleus Accumbens / Q000503:physiopathology*; D012559:Schizophrenia / Q000209:etiology* / Q000503:physiopathology; D012686:Septal Nuclei / Q000503:physiopathology*
D006632:Histamine; D004298:Dopamine