The effect of hemoperfusion over uncoated and polymer-coated charcoal on hematological levels in the conscious rat.
An investigation has been made of the suitability of a rat hemoperfusion system for the evaluation of hematological changes induced by charcoal hemoperfusion. The investigation studied the influence on erythrocyte, leucocyte and thrombocyte levels of repeated hemoperfusion over Norit RBX1 charcoal, hemoperfusion over polymer-coated Norit RBX1 and hemoperfusion over uncoated spherical charcoal. Controls included animals subjected to hemoperfusion through empty columns and animals cannulated only. The results indicate that changes in erythrocyte and leucocyte levels are due principally to passage of blood through the extracorporeal circuit rather than contact with the adsorbent but that changes in thrombocyte levels are dependent on the type of charcoal and the nature and extent of polymer coating. The investigation suggests that the rat hemoperfusion system is a suitable procedure for the assessment of the compatibility of adsorbents to be used in hemoperfusion.
D000181:Acrylonitrile / Q000031:analogs & derivatives; D000818:Animals; D001772:Blood Cell Count; D002606:Charcoal; D003243:Consciousness; D006464:Hemoperfusion; D008297:Male; D008768:Methylmethacrylates; D011108:Polymers; D011109:Polymethacrylic Acids; D051381:Rats; D011919:Rats, Inbred Strains
D008768:Methylmethacrylates; D011108:Polymers; D011109:Polymethacrylic Acids; D002606:Charcoal; C035600:dimethylaminoethyl methacrylate-methylmethacrylate copolymer; C012697:acrylonitriledimethylaminoethyl methacrylate copolymer; D000181:Acrylonitrile