A new subcutaneously-implantable reservoir for sustained release of nicotine in the rat.
A subcutaneously-implantable reservoir for the sustained release of nicotine is described. The device, dubbed INR for Implantable Nicotine Reservoir, is a small glass cup sealed with Silastic polymer. It releases 3.4 mg of nicotine per 24 hours. When implanted into moderately-sized female Sprague-Dawley rats it produces blood nicotine levels of 400-500 ng/ml which remain relatively stable over at least 18 days. INRs are nontoxic, reproducible, inexpensive, and adaptable for pharmacological and toxicological studies in rats and other small animals.
D000818:Animals; D004343:Drug Implants; D005260:Female; D009538:Nicotine / Q000008:administration & dosage* / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains
D004343:Drug Implants; D009538:Nicotine