The effects of intracerebroventricular administration of 5,6-dihydroxytryptamine to neonatal rats.
5,6-Dihydroxytryptamine was administered intracerebroventricularly to neonatal rats on days 3 and 6 (25, 50, 75 or 100 micrograms) or on day 12 (50, 75 or 100 micrograms) after birth. Administration on days 3 and 6 increased serotonin (5-HT) in the diencephalon, decreased it in the telencephalon and produced variable results in the brainstem. The dose of 100 micrograms eliminated the peak in locomotor activity that normally occurs at day 15. Administration on day 12 produced increased 5-HT levels in the diencephalon and the brainstem. The dose of 100 micrograms delayed the decrease in activity after the peak. Administration on days 3 and 6 or on day 12 produced non-specific damage throughout the brain, although dopamine levels were normal. The behavioral effects did not correspond with the neurochemical effects and probably were due to the pronounced non-specific effects of the treatment.
D015115:5,6-Dihydroxytryptamine / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects*; D001933:Brain Stem / Q000032:analysis; D002421:Caudate Nucleus / Q000032:analysis; D004027:Diencephalon / Q000032:analysis; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D012701:Serotonin / Q000032:analysis*; D013687:Telencephalon / Q000032:analysis
D012701:Serotonin; D015115:5,6-Dihydroxytryptamine