Cerebral vascular responses to ketamine and thiopentone during foetal acidosis.
Using a chronic sheep preparation, with induced foetal acidosis, the effects of low and high dose thiopentone and ketamine on maternal and foetal cardiovascular dynamics were studied. Ketamine 4 mg . kg-1 and thiopentone 10 mg . kg-1 were both associated with marked reductions in foetal cerebral blood flow and cerebral oxygen delivery. Blood pressure and cerebral blood flow in the acidotic foetus was better preserved, however, following the lower dose of ketamine 2 mg . kg-1 than following thiopentone 6 mg . kg-1.
D000138:Acidosis / Q000503:physiopathology*; D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D005315:Fetal Diseases / Q000503:physiopathology*; D005333:Fetus / Q000187:drug effects*; D007649:Ketamine / Q000009:adverse effects*; D011247:Pregnancy; D012756:Sheep; D013874:Thiopental / Q000009:adverse effects*
D007649:Ketamine; D013874:Thiopental