Long-term study on the effect of caffeine in Wistar rats.
Wistar rats of both sexes were given synthetic caffeine in their drinking water for 78 weeks. Three hundred Wistar rats were divided into three groups of 50 males and 50 females each. Group 1 was given normal tap water without caffeine as a control. Group 2 was given 0.1% caffeine solution and group 3 was given 0.2% caffeine solution for 78 weeks. All the animals were killed after 104 experimental weeks. Various tumors were found in both experimental and control groups, but their incidences were not higher in the experimental groups. Thus, there was no evidence that caffeine was carcinogenic to Wistar rats when given continuously in the drinking water for 78 weeks.
D000818:Animals; D002110:Caffeine / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002110:Caffeine