Modified megathrombocyte index in the diagnosis of thrombopoiesis injury produced by cancer chemotherapy.
The border-line separating the normal platelet from the megathrombocyte was lowered from 2.5 microns, classically used, to 2 microns. This modification allowed more precise definition of normal frequency of megathrombocytes among platelets (megathrombocyte index--MI) which was 10-35%. The modified MI determination demonstrated the same kinetics of changes following the intensive cancer chemotherapy as the classical one and, moreover, enabled individual diagnosis of thrombopoiesis perturbation induced by chemotherapy which was not possible with the classical MI.
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001792:Blood Platelets / Q000187:drug effects*; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count
D000970:Antineoplastic Agents