Ion-pair high-performance liquid chromatography of terbutaline and catecholamines with aminophylline in intravenous solutions.
A stability-indicating ion-pair high-performance liquid chromatographic (HPLC) assay that is rapid and specific for epinephrine, isoproterenol, dopamine, norepinephrine, methyldopate, or terbutaline in intravenous solutions with aminophylline has been developed using a spectrofluorometric detector. A HPLC method for the analysis of terbutaline and methyldopate is introduced, and the superiority of fluorometric over UV detection of terbutaline and the catecholamines is illustrated.
D000628:Aminophylline / Q000032:analysis*; D002395:Catecholamines / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D007275:Injections, Intravenous; D012996:Solutions / Q000032:analysis; D013050:Spectrometry, Fluorescence / Q000379:methods; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013726:Terbutaline / Q000032:analysis*
D002395:Catecholamines; D012996:Solutions; D000628:Aminophylline; D013726:Terbutaline