Actions of D 600 on isolated rabbit aorta.
1. The actions of D 600 (10(-9)-10(-4) M) on various phases of NE- or Ca2+-induced contractions of rabbit isolated aorta were determined in Ca2+-free medium. 2. D 600 inhibited the slow phase of contraction with EC50 approximately equal to 3 X 30(-8) M, but affected the rapid phase of contraction only at 10(-4) M. 3. D 600 increased the relaxation that followed the rapid phase of NE-induced contraction in Ca2+-free medium with EC50 approximately equal to 1.5 X 10(-5) M. 4. The method described might be useful for further studies on Ca2+-antagonists.
D000818:Animals; D001011:Aorta / Q000187:drug effects*; D002118:Calcium / Q000494:pharmacology; D005711:Gallopamil / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D011817:Rabbits; D014700:Verapamil / Q000031:analogs & derivatives*
D005711:Gallopamil; D014700:Verapamil; D002118:Calcium