Evidence for placing the Neu-1 locus within the mouse H-2 complex.
Congenic lines B10.KPA42, B10.KPA132, B10.SNA57, B10.DRB62, and B10.WOA105 carry H-2 haplotypes of wild mice on the genetic background of the strain C57BL/10Sn. Two of the lines (B10.DRB62 and B10.WOA105) have H-2 haplotypes indistinguishable from H-2v of B10.SM. The H-2 haplotype of one line (B10.SNA57) seems to have arisen from H-2v by recombination between the D and Qa-2 loci. The H-2 haplotypes of the remaining two lines probably arose from H-2v by recombination between the C4 and D loci. Since all six and no other lines carry the rare Neu-1a allele, the neuraminidase-1 locus is probably located proximal to the H-2D locus. Typing of H-2s recombinants for the enzyme acid phosphatase liver, the processing of which is controlled by the Neu-1 locus, suggests that the locus resides between the E alpha and D loci, that is in the S region.
D000135:Acid Phosphatase / Q000032:analysis / Q000235:genetics; D000483:Alleles; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004592:Electrophoresis, Starch Gel; D006183:H-2 Antigens / Q000235:genetics*; D008099:Liver / Q000201:enzymology; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D009439:Neuraminidase / Q000276:immunology / Q000494:pharmacology
D000911:Antibodies, Monoclonal; D006183:H-2 Antigens; D000135:Acid Phosphatase; D009439:Neuraminidase