Evidence for beta-adrenergic activation of Na+-dependent efflux of Ca2+ from isolated liver mitochondria.
The existence of a Na(+)-dependent mechanism for Ca(2+) efflux from isolated rat liver mitochondria was confirmed. The activity of this system is decreased by 60% in mitochondria isolated from perfused livers. The Na(+)-dependent activity is fully restored by infusion of either 1mum-adrenaline or 1mum-isoprenaline, but the alpha-adrenergic agonist phenylephrine is ineffective.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D004837:Epinephrine / Q000494:pharmacology*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D012964:Sodium / Q000494:pharmacology*; D013268:Stimulation, Chemical
D010656:Phenylephrine; D012964:Sodium; D007545:Isoproterenol; D002118:Calcium; D004837:Epinephrine