Massive hyperstimulation and borderline carcinoma of the ovary. A possible association.
A patient with persistent ovarian cysts subsequent to clomiphene-induced severe hyperstimulation was found to have borderline ovarian carcinoma. Since several endocrine and epidemiological studies implicate hormonal factors in the genesis of ovarian tumors, a possible association between ovarian hyperstimulation and neoplasia is suggested.
D000328:Adult; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D002996:Clomiphene / Q000494:pharmacology*; D003537:Cystadenoma / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy; D010048:Ovarian Cysts / Q000150:complications*; D010051:Ovarian Neoplasms / Q000209:etiology* / Q000473:pathology; D010053:Ovary / Q000187:drug effects* / Q000473:pathology
D006063:Chorionic Gonadotropin; D002996:Clomiphene