A new specific inhibitor of monoamine oxidase A.
A new propynylamine has been tested as an inhibitor of MAO. Loosely based upon the structure of clorgyline, it is an irreversible inhibitor of MAO A but is apparently indifferent towards MAO B. This compound, N1-(2,4-dinitrophenyl)-N2-prop-2-ynyl 1,3-diaminopropane, may be useful as a model for the design of more potent but equally specific inhibitors of MAO A.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003959:Diamines / Q000494:pharmacology*; D066298:In Vitro Techniques; D008930:Mitochondria, Liver / Q000201:enzymology; D008996:Monoamine Oxidase Inhibitors; D051381:Rats
D003959:Diamines; D008996:Monoamine Oxidase Inhibitors; C035487:dinitranyl