Enhancement of formylmethionyl-leucyl-phenylalanine-induced directional locomotion of human neutrophils by serum low-density lipoproteins.
Human low-density lipoproteins (LDL) significantly increased neutrophil locomotion in a gradient of the chemotactic peptide formyl-methionyl-leucyl-phenylalanine (FMLP), while LDL alone had no effect on either directional or random locomotion. The enhancing effect on directional locomotion was constantly observed at FMLP concentrations of 10(-8) M and 5 X 10(-8) M after addition of 50 microgram LDL/ml.
D002465:Cell Movement; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008560:Membrane Fluidity; D008565:Membrane Proteins / Q000502:physiology; D008715:Methionine / Q000031:analogs & derivatives*; D009239:N-Formylmethionine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009240:N-Formylmethionine Leucyl-Phenylalanine; D009504:Neutrophils / Q000502:physiology*; D009842:Oligopeptides / Q000494:pharmacology*
D008077:Lipoproteins, LDL; D008565:Membrane Proteins; D009842:Oligopeptides; D009239:N-Formylmethionine; D009240:N-Formylmethionine Leucyl-Phenylalanine; D008715:Methionine