Biochemical effects of the plant Lantana camara on guinea pig liver mitochondria.
Lantana camara caused, in guinea pigs, a decrease in hepatic mitochondrial protein content. The phospholipid to protein ratio did not change but there was a marked increase in the cholesterol to protein ratio and the cholesterol to phospholipid ratio. Enzyme activities of succinic dehydrogenase, glutamate dehydrogenase, cytochrome oxidase and Mg2+-ATPase increased, while the activity of NADH-ferricyanide reductase remained unaffected. Mitochondrial swelling, in the absence or presence of ascorbic acid, decreased in hepatic mitochondria from lantana-intoxicated guinea pigs.
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D010947:Plants, Toxic; D011506:Proteins / Q000378:metabolism
D010743:Phospholipids; D010936:Plant Extracts; D011506:Proteins; D002784:Cholesterol