Exchange mechanism of tyrosine between plasma and red blood cells in normal subjects and psychiatric patients.
The saturable mechanism of tyrosine (TYR) uptake by the membrane of red blood cells incubated at 37 degrees C has been studied in normal subjects and psychiatric patients. This uptake is markedly inhibited by incubation at 0 degree C, and weakly inhibited by iodoacetic acid and ouabain. The uptake of TYR is significantly lower in unipolar- and bipolar-depressed patients, and significantly higher in schizophrenics compared to normal controls. These results indicate a possible disturbance of functional capacity of membrane transport in some psychiatric diseases.
D001692:Biological Transport; D001714:Bipolar Disorder / Q000097:blood; D002462:Cell Membrane / Q000378:metabolism; D003080:Cold Temperature; D003866:Depressive Disorder / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D007461:Iodoacetates / Q000494:pharmacology; D010042:Ouabain / Q000494:pharmacology; D010949:Plasma / Q000378:metabolism*; D011618:Psychotic Disorders / Q000097:blood*; D012559:Schizophrenia / Q000097:blood; D014443:Tyrosine / Q000097:blood*
D007461:Iodoacetates; D014443:Tyrosine; D010042:Ouabain