Bacteriuria during follow-up in patients with spinal cord injury: II Efficacy of antimicrobial suppressants.
Data from serial follow-up evaluations of 103 patients with traumatic or atraumatic myelopathy were recorded to determine rates significant bacteriuria in groups using different antimicrobial suppressive regimens or no pharmacologic agents. Rates of urinary tract infection were compared in patient taking methenamine salts with urinary acidifiers, co-trimoxazole, or no drug. At all follow-up period rates of infection were consistently lower in the groups taking methenamine and co-trimoxazole than in the group not taking a drug, the group taking co-trimoxazole having the lowest rates. These results suggest that the long-term use of antimicrobial suppressants can help reduce rates of urinary tract infection in bladder-retrained patients and in patients emptying by intermittent self-catheterization.
D000892:Anti-Infective Agents, Urinary / Q000627:therapeutic use*; D001437:Bacteriuria / Q000209:etiology / Q000517:prevention & control*; D005500:Follow-Up Studies; D006801:Humans; D008709:Methenamine / Q000627:therapeutic use; D013119:Spinal Cord Injuries / Q000150:complications*; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use
D000892:Anti-Infective Agents, Urinary; D014295:Trimethoprim; D008709:Methenamine; D013420:Sulfamethoxazole