title: [Clinical significance of time dose distribution in radiotherapy].
abstract: A survey is given of the mathematical and empirical methods allowing to compare different chronological dose distributions; their possibilities and limits are described. The experimental bases of hyper- and superfractionation and the clinical experiences gained hitherto with multiple daily irradiations are communicated; radiotherapy with high individual fractions and long term irradiation are shortly explained. Finally some hints are given for the further development and the practical use of not typical fractionation schemes.
mesh_terms: D006801:Humans; D008433:Mathematics; D011878:Radiotherapy; D011879:Radiotherapy Dosage; D013997:Time Factors
vernacular_title: Die klinische Bedeutung der zeitlichen Dosisverteilung in der Radiotherapie.