title: Effect of serum caffeine level on pneumocardiogram of premature infants treated for apnea with theophylline.
abstract: It is speculated that measurement of serum theophylline concentration alone, without concomitant caffeine level determination, may lead to a false negative (normal) pneumocardiogram due to possible existence of therapeutic caffeine level resulting from the methylation of theophylline. Treatment of neonatal apnea with theophylline as documented by a normal follow-up pneumocardiogram should be considered successful only when the levels of both theophylline and caffeine have been documented subtherapeutic at time of re-test.
mesh_terms: D001049:Apnea / Q000188:drug therapy*; D002110:Caffeine / Q000097:blood*; D004562:Electrocardiography; D005188:False Negative Reactions; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy*; D007234:Infant, Premature; D012119:Respiration; D013806:Theophylline / Q000097:blood / Q000627:therapeutic use*
chemical_list: D002110:Caffeine; D013806:Theophylline