title: Serum oestrone, oestradiol and oestriol levels in ovariectomized women receiving a high dose of oestradiol valerate.
abstract: Fourteen recently ovariectomized women received 4 mg of oestradiol valerate therapy daily for 6 mth. Serum oestrogens were measured by radioimmunoassay at monthly intervals. The results of therapy produced a 25-fold increase in serum oestrone (E1) concentration. Circulating oestradiol (E2) increased 5-to 6-fold. No accumulation of oestrogens was observed as a consequence of treatment. Serum concentration of oestriol (E3) showed no elevation. One month after the completion of therapy the E1 and E2 concentrations had returned to pre-treatment levels. Although therapy of high-dose oestradiol valerate was well-tolerated, it is not recommended because of the non-physiological high serum concentrations of oestrone and high serum level of oestradiol.
mesh_terms: D002369:Castration; D004958:Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood* / Q000494:pharmacology; D004964:Estriol / Q000097:blood*; D004970:Estrone / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged
chemical_list: D004970:Estrone; D004958:Estradiol; D004964:Estriol