Cortisol suppression index: a new approach to interpreting the DST in depression.
The cortisol suppression index (CSI) is a ratio of pre- to postdexamethasone plasma cortisol concentrations. In a sample of 24 psychiatric inpatients, an 8 a.m. CSI detected 66% of patients with major depression. Further studies with larger samples and additional controls, including normal subjects, are suggested to validate these prospective findings. This index may serve as a useful and more practical way of detecting major depression in outpatients.
D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D001714:Bipolar Disorder / Q000097:blood / Q000175:diagnosis; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis*; D003907:Dexamethasone; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D001523:Mental Disorders / Q000097:blood / Q000175:diagnosis; D008875:Middle Aged; D011446:Prospective Studies
D003907:Dexamethasone; D006854:Hydrocortisone