Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro.
Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma cells but had little effect on nontumorigenic epithelial cells in vitro. This selective inhibitory effect of Rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.
D000818:Animals; D002277:Carcinoma / Q000188:drug therapy*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000188:drug therapy; D020112:Rhodamine 123; D012235:Rhodamines / Q000378:metabolism / Q000627:therapeutic use; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy
D012235:Rhodamines; D020112:Rhodamine 123