Personality traits and theophylline metabolism.
The objectives of this study were to investigate the relationship between personality trait variables and theophylline disposition in asthmatic patients. Twenty-five patients admitted to a hospital who required intravenous theophylline for bronchodilation were studied. Data on theophylline half-life, and the patients' histories on congestive heart failure, liver disease, and smoking behaviour were abstracted. Eysenck's personality inventory was administered to obtain a score on the two personality traits: neuroticism and extraversion. High neurotic patients showed a significantly (p less than 0.005) lower theophylline half-life. Neuroticism appeared to be, in this patient population, a more important determinant of theophylline half-life than variables such as congestive heart failure, liver disease, or smoking behaviour.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000378:metabolism* / Q000523:psychology; D002648:Child; D005260:Female; D006207:Half-Life; D006333:Heart Failure / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008107:Liver Diseases / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010551:Personality; D012907:Smoking; D013806:Theophylline / Q000378:metabolism*
D013806:Theophylline