title: Pharmacokinetic properties of carprofen in humans.
abstract: In this overview the pharmacokinetic behaviour of carprofen in healthy subjects is described. Carprofen is rapidly and completely absorbed. The maximum concentration in plasma is reached after 1 hour and the absolute bioavailability of the oral forms reaches values of over 90%. The elimination half-life is 10 hours. The multiple-dose kinetics could be predicted adequately, using pharmacokinetic parameters of the single-dose kinetics. A clear accumulation of carprofen in plasma was not observed. In clinical-therapeutic use the kinetics are not significantly influenced by food intake or by age.
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000097:blood / Q000378:metabolism*; D002227:Carbazoles / Q000097:blood / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004435:Eating; D006801:Humans; D007700:Kinetics; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D002227:Carbazoles; C007005:carprofen