The pharmacokinetics of azlocillin in the perilymph of guinea pigs and otitis media.
The results of studies on the pharmacokinetics of azlocillin in the perilymph of the guinea pig following the intramuscular administration of 200 mg per kg body weight are shown graphically. Similar to mezlocillin and the aminoglycoside antibiotics, this new acylureido penicillin is retained in the inner ear. The results of our studies, together with the data on the in vitro and in vivo activity of azlocillin and gentamicin and the applicable dosage for clinical purposes, indicate that the azlocillin levels in the perilymph are considerably more effective against Pseudomonas aeruginosa and many times more effective against the other microorganisms usually involved in acute otitis media than those of the aminoglycosides.
D000818:Animals; D001390:Azlocillin; D006168:Guinea Pigs; D007700:Kinetics; D007761:Labyrinthine Fluids / Q000378:metabolism*; D010033:Otitis Media / Q000188:drug therapy*; D010406:Penicillins / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D010498:Perilymph / Q000032:analysis / Q000378:metabolism*
D010406:Penicillins; D001390:Azlocillin