title: Effect of dietary protein and lipid on the activity of hepatic mixed-function oxidase system in young and adult rats.
abstract: Effects of marginal or normal casein diets with different sunflower oil contents were tested on the hepatic mixed-function oxidase system in young and adult male rats. The weight gain and the activity of aminopyrine demethylase, aniline hydroxylase and the content of cytochrome P-450 was decreased only in young rats fed 10% casein and 10% oil containing diets. Both in young and adult animals, independently of casein consumption, the activity of MFO with the exception of cytochrome P-450 in adult rats fed 20% casein was significantly higher when the level of dietary sunflower oil was shifted from 10 to 30%.
mesh_terms: D000375:Aging; D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D002364:Caseins / Q000008:administration & dosage*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage*; D008099:Liver / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013367:Submitochondrial Particles / Q000201:enzymology
chemical_list: D002364:Caseins; D004041:Dietary Fats; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D000815:Aniline Hydroxylase; D000633:Aminopyrine N-Demethylase