title: Chemotherapy and chemoprophylaxis of Angiostrongylus malaysiensis infection in rats with levamisole and mebendazole.
abstract: The chemoprophylactic and chemotherapeutic effects of levamisole and mebendazole on Angiostrongylus malaysiensis infection in rats were studied. Both drugs were ineffective in preventing infection while the post-infection treatment showed 100% efficacy. Furthermore, levamisole and mebendazole when given in combination appeared to have an antagonistic effect.
mesh_terms: D000284:Administration, Oral; D000801:Angiostrongylus; D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D007978:Levamisole / Q000008:administration & dosage / Q000627:therapeutic use*; D008463:Mebendazole / Q000008:administration & dosage / Q000627:therapeutic use*; D009349:Nematode Infections / Q000188:drug therapy* / Q000517:prevention & control; D051381:Rats
chemical_list: D001562:Benzimidazoles; D007978:Levamisole; D008463:Mebendazole