Metabolic fate of hexabromobenzene in rats.
To study the metabolic fate of hexabromobenzene (HBB) in female rats, the substance was administered in oral doses of 16.6 mg/kg body weight every other day for 2 weeks and the animals' excreta were examined for metabolites. Unchanged HBB, pentabromobenzene, oxygen- and sulphur-containing metabolites were detected in feces and urine. The sulphur-containing substances contained free mercapto groups except for the presence in feces of a methylmercapto derivative. The amount of sulphur-containing metabolites was estimated to be 15 times greater than that of oxygen-containing compounds. The relative proportions of the unchanged compound and its metabolites in the excreta were about 1:4.
D000818:Animals; D001711:Biotransformation; D001969:Bromobenzenes / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D005978:Glutathione / Q000378:metabolism; D008970:Molecular Weight; D051381:Rats; D011919:Rats, Inbred Strains
D001969:Bromobenzenes; D005978:Glutathione; C017363:hexabromobenzene