Bone resorption under the influence of parathyroid hormone in vitro.
Parathyroid-induced bone resorption in vitro was observed by phase contrast microscope, 16 mm time-lapse cinemicrograph, light- and electron microscope. These findings led us to the following conclusions. That is, the macrophages seem to be capable of resorbing the bone tissue, and perhaps they may degrade and digest the collagen fibers, while the osteoclasts may resorb the bone minerals. The osteoclasts are destined to extinction after about two to three weeks of life span.
D000818:Animals; D001862:Bone Resorption / Q000187:drug effects*; D002478:Cells, Cultured; D008264:Macrophages / Q000166:cytology / Q000502:physiology*; D008853:Microscopy; D010010:Osteoclasts / Q000166:cytology / Q000502:physiology*; D010281:Parathyroid Hormone / Q000494:pharmacology*; D051381:Rats
D010281:Parathyroid Hormone