[Effect of simultaneous administration of morphine and naloxone on the exploratory behavior of mice].
The authors, after going carefully over the specific bibliography on the matter, report their results relating to exploratory behaviour in mice after simultaneous administration with morphine (1 mg/kg i.p.) and naloxone (0,05 mg/kg i.p.). Exploratory behaviour was evaluated using an automatic recording hole-board, that simultaneously registered the locomotor activity. Morphine and naloxone simultaneously administered produced, at the used doses, a significant statistic decrease in exploratory behaviour, while locomotor activity was unchanged, in comparison with drug-naive subjects. At the end, some possible interpretations are proposed about obtained results.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004347:Drug Interactions; D005106:Exploratory Behavior / Q000187:drug effects*; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology*
D009270:Naloxone; D009020:Morphine
Effetto della contemporanea somministrazione di morfina e naloxone sul comportamento esplorativo di topi.