Thrombin-induced platelet malondialdehyde (MDA) formation in normal subjects and in women taking oral contraceptives.
Thrombin-induced platelet malondialdehyde (MDA) production and platelet count were studied in 82 male and 74 female healthy blood donors. 37 women on oral contraceptives (OC) had significantly lower values of MDA production than women who were not using the pill. There were no statistically significant differences of MDA production in women on a low dose estrogen, a medium dose, and a relatively high dose. Males had significantly higher values than females. In 15 further subjects (5 males, 5 OC-users, 5 OC-nonusers) the kinetics of MDA formation was determined by using increasing doses of thrombin. No significant differences could be found. Platelet count in women on OCs was lightly increased, but the difference was not significant.
D001792:Blood Platelets / Q000187:drug effects*; D003276:Contraceptives, Oral / Q000008:administration & dosage*; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008314:Malonates / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood*; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count; D013917:Thrombin / Q000008:administration & dosage*
D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D008314:Malonates; D008315:Malondialdehyde; D013917:Thrombin