[Adenine arabinoside treatment of varicella and generalized herpes zoster in 43 immunosuppressed patients].
Forty-three immunosuppressed patients presenting with varicella or generalized herpes zoster were treated with adenine arabinoside (as monophosphate in 10 patients). All those who received the recommended 5-day course were rapidly cured without relapse; the skin lesions were virus-free after the 5th days of treatment. Five patients with malignant varicella involving several organs and who had only been treated for a few hours died. It is concluded that adenine arabinoside is a useful drug in VZ virus infections, although it has no immediate action. The monophosphate presentation, more soluble and requiring lesser amounts of solvent, is easier to administer and as effective as the ordinary presentation.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002644:Chickenpox / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006562:Herpes Zoster / Q000188:drug therapy*; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy; D013997:Time Factors; D014740:Vidarabine / Q000009:adverse effects / Q000627:therapeutic use*
D014740:Vidarabine
Traitement par l'adénine-arabinoside des varicelles et zonas généralisés chez 43 malades immunodéprimés.