Inotropic and electrophysiological effects of tolbutamide in normal subjects.
The acute cardiac effects of tolbutamide on myocardial contractility, evaluated with systolic time intervals (ST), and on the atrio-ventricular conduction system have been studied in a group of five volunteer normal subjects. The intravenous administration of 1 g of tolbutamide showed no considerable changes of STI and of electrophysiologic parameters. Glycemia decreased whereas there was a statistically significant increase in plasmatic levels of catecholamines at the 10th and 20th min. Our findings suggest that the intravenous administration of tolbutamide has no effect either on the atrio-ventricular conduction system or on myocardial contractility in normal men.
D000328:Adult; D005260:Female; D006321:Heart / Q000187:drug effects*; D006329:Heart Conduction System / Q000187:drug effects; D006801:Humans; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D013599:Systole / Q000187:drug effects; D014044:Tolbutamide / Q000494:pharmacology*
D014044:Tolbutamide