Effect of peripheral blood lymphocytes from systemic lupus erythematosus patients on human bone marrow granulocyte precursor cells (colony-forming units in culture).
Because of the possibility that immunological mechanisms might be involved in the pathogenesis of leukopenia accompanying systemic lupus erythematosus (SLE), the effect of lymphocytes on colony-forming units in culture (CFU-C) was compared. The colony formation of the bone marrow CFU-C of SLE patients was less than that of the healthy subjects. Lymphocytes of SLE patients and serum of some of the SLE patients remarkably inhibited colony formation by human bone marrow CFU-C. The results shown above suggest the possibility that immunocompetent cells of the patients are involved in the pathogenesis of leukopenia in SLE.
D000293:Adolescent; D000328:Adult; D001769:Blood; D001854:Bone Marrow Cells; D003114:Colony-Forming Units Assay; D005260:Female; D006098:Granulocytes / Q000166:cytology*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D007958:Leukocyte Count; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D008214:Lymphocytes; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use
D011239:Prednisolone