[Quantitative evaluation of the blood-depressing action of alkylating agents].
It has been found that paphencyl, preparations II-72 and II-119 decrease to an equal measure the leukocyte count in the peripheral blood and the myelokaryocyte count in animals immunized with sheep red blood cells and in intact CBA mice. The maximal action develops by the 2nd-3rd day after cytostatic administration. Immune reactions of mice were shown to be more susceptible to the action of the drugs under study as compared to hemopoiesis.
D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D001772:Blood Cell Count; D001773:Blood Cells / Q000187:drug effects*; D001853:Bone Marrow / Q000187:drug effects; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D051379:Mice; D008808:Mice, Inbred CBA; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology
D000477:Alkylating Agents; D003509:Cyclohexanecarboxylic Acids; D009588:Nitrogen Mustard Compounds; C031372:pafencil; C032967:Ts-119; C032966:Ts-72
Kolichestvennaia otsenka gemodepressivnogo deĭstviia nekotorykh alkiliruiushchikh agentov.