Effect of dextro-amphetamine on reticulo-preoptic interactions in "encéphale isolé" cats.
Intravenous administration of a single dose of dextro-amphetamine (1 mg/kg) in the "encéphale isolé" cat significantly increased amplitude of the P50 and N110 components of the preoptic potential evoked by the stimulation of the mesencephalic reticular formation and decreased all components of the mesencephalic reticular formation potential evoked by preoptic stimulation. Concomitantly, a state of increased and persistent arousal response was found. These findings support the idea that during wakefulness there is a reticular facilitation and a preoptic inhibition.
D000818:Animals; D001143:Arousal / Q000187:drug effects; D002415:Cats; D003655:Decerebrate State; D003913:Dextroamphetamine / Q000494:pharmacology*; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D008297:Male; D008636:Mesencephalon / Q000187:drug effects*; D009433:Neural Inhibition / Q000187:drug effects*; D009434:Neural Pathways / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D011301:Preoptic Area / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D012154:Reticular Formation / Q000187:drug effects*
D003913:Dextroamphetamine