title: Flow cytometry of human testicular tissue.
abstract: Flow cytometry of testicular tissue from autopsies showed differences in the proportion of substained spermatozoa (1 CA), spermatids (1 CB), diploid 2C nuclei and premeiotic spermatozoa in the 4 C class. The evaluation of the histograms was performed with computer assistance. Healthy accident cases or those delivered in forensic medicine furnished the control values. Patients with hepatic cirrhosis showed a nearly complete loss of the haploid class, while cases with fatty degeneration of the liver demonstrated a reduction. Circulatory insufficiency in cases of acute shock resulted in an increase in the 4C values of meiotic prophase I and a decrease of spermatids. Spermatozoa were normal in these cases. After prolonged shock a nearly complete breakdown of spermatogenesis was observed. In cases of atherosclerosis an irregular degree of reduction was seen. Cancer patients showed a reduction of spermatogenesis in correlation to therapy.
mesh_terms: D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000473:pathology; D004247:DNA / Q000032:analysis*; D005434:Flow Cytometry; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000473:pathology; D012769:Shock / Q000473:pathology; D013091:Spermatogenesis; D013737:Testis / Q000032:analysis / Q000473:pathology*
chemical_list: D004247:DNA