Effects of 15-hydroperoxyeicosatetraenoic acid on human lymphocyte sheep erythrocyte rosette formation and response to concanavalin A associated with HLA system.
The lipoxygenase product hydroperoxyeicosatetraenoic acid (HPETE) has immunosuppressive properties in vitro and in vivo. It was observed that 15-HPETE inhibit the sheep red blood cell rosette formation and the concanavalin A-induced blast transformation of human lymphocytes. This inhibition was HLA-linked. HLA-B12 subjects were less sensitive than non-B12 subjects. It is likely that HPETE acids are macrophage mediators which inhibit some lymphocyte functions.
D000293:Adolescent; D000328:Adult; D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D003208:Concanavalin A / Q000494:pharmacology; D004912:Erythrocytes / Q000276:immunology; D006680:HLA Antigens; D006801:Humans; D007166:Immunosuppressive Agents; D066298:In Vitro Techniques; D015289:Leukotrienes; D008054:Lipid Peroxides; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D012397:Rosette Formation; D012756:Sheep
D001095:Arachidonic Acids; D006680:HLA Antigens; D007166:Immunosuppressive Agents; D015289:Leukotrienes; D008054:Lipid Peroxides; D003208:Concanavalin A; C025086:15-hydroperoxy-5,8,11,13-eicosatetraenoic acid