title: Aluminum absorption in the rat everted gut sac.
abstract: Intestinal absorption of aluminum was studied in rat everted gut sacs. Aluminum transport and aluminum uptake in the jejunum initially rose with increasing bath aluminum concentration, but reached a plateau with high bath aluminum concentrations. The aluminum transport was inhibited by dinitrophenol, absence of glucose, and a temperature of 4 degrees C. There was no change with acute renal failure, chronic renal failure, parathyroidectomy, or parathyroid hormone injection. The aluminum absorption from the rat jejunum appears to involve an energy-dependent, carrier-mediated mechanism.
mesh_terms: D000535:Aluminum / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000494:pharmacology; D004140:Dinitrophenols / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000494:pharmacology; D007408:Intestinal Absorption / Q000187:drug effects; D007583:Jejunum / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004140:Dinitrophenols; D000535:Aluminum; D005947:Glucose; D002118:Calcium