[Effect of different classes of psychotropic substances on 14C-glutamate uptake by crude synaptosomal fractions in the rat brain].
Effects of different psychotropic drugs on the reverse uptake of glutamate by rat brain synaptosomes were investigated. The KM values for glutamate transport by high affinity and low affinity systems were calculated (30 and 300 microM, respectively). It is shown that neuroleptics, antidepressants, tranquilizers, psychostimulants, and narcotic analgesics at a concentration of 50 microM had no influence on the high affinity glutamate uptake. Meanwhile neuroleptics and tricyclic antidepressants at a concentration of 500 microM partly inhibited this process. The anticonvulsant diphenylhydantoin at a concentration of 500 microM stimulated synaptosomal uptake of glutamate. It is concluded that there is no correlation between the effects of psychotropic drugs on glutamate uptake and their specific action on the central nervous system.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002250:Carbon Radioisotopes; D004305:Dose-Response Relationship, Drug; D005971:Glutamates / Q000378:metabolism*; D066298:In Vitro Techniques; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects* / Q000378:metabolism
D002250:Carbon Radioisotopes; D005971:Glutamates; D011619:Psychotropic Drugs
Vliianie psikhotropnykh veshchestv raznykn klassov na zakhvat 14C-glutamata gruboĭ sinaptosomal'noĭ fraktsieĭ mozga krys.