Methods for evaluating optimal dosage regimens and their application to theophylline.
For a certain class of drugs blood levels can be used to monitor therapy. Based on the concept of a target concentration strategy criteria for optimal treatment schemes are given. The goal of these criteria is to define dose regimens that lead to concentrations within the target concentration range. The performance indices of these criteria are evaluated and applied to the dose regimen assessment for theophylline.
D000284:Administration, Oral; D004334:Drug Administration Schedule; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008954:Models, Biological; D013806:Theophylline / Q000008:administration & dosage* / Q000378:metabolism
D013806:Theophylline