title: [Metabolism-embryotoxicity relationship of febantel in the rat and the sheep].
abstract: The metabolism of febantel has been investigated in the rat and the sheep. The general pathway seems to be similar in both species: ten urinary metabolites are the result of cyclisation, oxidation and/or hydrolysis process. Using synthetic samples, the embryotoxic study of all individual metabolites has been performed in the rat. Unchanged febantel and two other metabolites are responsible for teratogenic effects. A four steps toxogenic pathway is described which finally leads to the ultimate known teratogen: methyl (5-(phenylsulfinyl)-1H-benzimidazole-2-yl) carbamate. Metabolic similarities with other anthelmintics and residual consequences are discussed.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology / Q000662:veterinary; D000818:Animals; D000871:Anthelmintics / Q000378:metabolism* / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D005313:Fetal Death / Q000139:chemically induced / Q000662:veterinary; D006146:Guanidines / Q000378:metabolism* / Q000633:toxicity; D011247:Pregnancy; D051381:Rats / Q000378:metabolism*; D011919:Rats, Inbred Strains; D012376:Rodent Diseases / Q000139:chemically induced; D012756:Sheep / Q000378:metabolism*
chemical_list: D000871:Anthelmintics; D006146:Guanidines; C017309:febantel
vernacular_title: Relation métabolisme-embryotoxicité du fébantel chez le rat et le mouton.