[Experimental intramural myocardial infarction in the rat. A morphometrical method for a quantitative evaluation of the drug's influence].
Arteria coronaris sinistra of female rats, Wistar strain, was ligated for 10 min. All successfully operated animals were decapitated at 96th h after the intervention. The serial histological heart slices to full coverage of the myocardial lesion revealed intramural infarctions in both the control and experimental rats, the former having been subjected to only a 10 min occlusion of the coronary artery and the latter having been treated with Propranolol or Dipyridamole. The myocardial lesions were invisible to the naked eye. They consisted of a necrotic center and a large reactive zone of mononuclear cells. The severity of the experimental disease was expressed by indices of myocardial lesions, based on the objective estimation of the infarct dimension. Propranolol (20 mg/kg, ip) or Dipyridamol (20 mg/kg, ip) applied to rats with induced myocardial infarction minished significantly the indice, of myocardial lesion. The high correlation coefficients of this indication, calculated at intervals between the slices of 0.1 to 0.4 mm, allowed the indices to be determined by a smaller number of slices-thus the work is being simplified. Graphic illustration of the transversal infarct areas along the longitudinal axis of the heart permitted to trace the topography of the drug's pharmacological action.
D000818:Animals; D003331:Coronary Vessels; D004176:Dipyridamole / Q000627:therapeutic use; D005260:Female; D008026:Ligation; D009203:Myocardial Infarction / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D011433:Propranolol / Q000627:therapeutic use; D051381:Rats; D013997:Time Factors
D004176:Dipyridamole; D011433:Propranolol
Experimenteller intramuraler Myokardinfarkt bei Ratten. Eine morphometrische Method zur quantitativen Auswertung der Arzneimittelwirkung.