title: [Respiratory-tract-directed immunostimulation by a vaccine administered by the oral route].
abstract: For testing the respiratory immunizing efficacy of an oral vaccine, 61 volunteer subjects were vaccinated with a double blind ribosomal vaccine. Although no clinical progress was observed in the treated group, there was however a significant rise in specific antibodies against each bacteria. In contrast, no rise in total seric immunoglobulins could be observed. The study of 115 salivary and bronchial IgA showed a significant rise in bronchial 11s IgA in the treated children's group. This data suggested the hypothesis of a stimulation of the whole immunosecretory system (mucous) by the vaccinotherapy alone by the oral route.
mesh_terms: D000284:Administration, Oral; D000907:Antibodies, Bacterial / Q000032:analysis*; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D001980:Bronchi / Q000276:immunology*; D002648:Child; D005260:Female; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000276:immunology; D012270:Ribosomes / Q000276:immunology; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007071:Immunoglobulin A, Secretory
vernacular_title: Immunostimulation à visée respiratoire par un vaccin administré par voie orale.