Ganglioside changes during cell aging in human diploid fibroblast TIG-1.
Gangliosides of human diploid fibroblast, TIG-1, derived from fetal lung were analyzed during cell aging. The major gangliosides of TIG-1 cells were GM3 and GD3. During cell aging, GM3 and other gangliosides were decreased or below detection level. Lipid-bound sialic acid per mg protein was 2 micrograms at the early, middle and late passages, but between the middle and late passage it was twofold higher than the other passages.
D002452:Cell Count; D002460:Cell Line; D002470:Cell Survival; D004171:Diploidy; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000378:metabolism*; D005677:G(M1) Ganglioside / Q000378:metabolism; D005679:G(M3) Ganglioside / Q000378:metabolism; D005732:Gangliosides / Q000378:metabolism*; D006801:Humans; D008168:Lung
D005679:G(M3) Ganglioside; D005732:Gangliosides; D005677:G(M1) Ganglioside; C026226:ganglioside, GD3