A new radioactive drug selectively accumulating in Melanoma cells.
The biological effects brought about by the selective accumulation of 35S-labelled methylthionine bromide (MTB) in pigmented hamster melanoma cells were examined in vitro and vivo. In vitro incubation of melanoma cells 35S-carrier-containing medium was found to suppress mitotic activity within 150 h whereas the same concentration before reimplantation into the skin, a clear-out correlation between 35S radioactivity and the capacity of growth initiation could be found. The growth of melanoma in situ could also be delayed by injecting the 35S-carrier to tumour-bearing animals.
D000818:Animals; D001965:Bromides / Q000378:metabolism; D002478:Cells, Cultured; D006224:Cricetinae; D003470:Culture Media; D007700:Kinetics; D008545:Melanoma / Q000378:metabolism* / Q000473:pathology; D008647:Mesocricetus; D013997:Time Factors; D014814:Vitamin U / Q000378:metabolism*; D014815:Vitamins / Q000378:metabolism*
D001965:Bromides; D003470:Culture Media; D014815:Vitamins; D014814:Vitamin U