Changes in the rosette forming capacity of lymphocytes after surgery or surgery and immunochemotherapy of malignant melanoma in man.
The E-rosette forming capacity of lymphocytes was measured in 39 melanoma patients, performing the test at 4 degrees C and at 20 degrees C, prior to treatment, following surgery, and in 11 patients was carried out at three points: before and after surgery as well as after immunochemotherapy with DTIC and BCG. The results have shown a marked depression in E-rosettes at 4 degrees C and at 20 degrees C, whereas more expressed inhibition was registered at 4 degrees C. Following surgical removal there were no significant changes in the E-rosettes. After immunochemotherapy an increase of the E-rosettes was observed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001500:BCG Vaccine / Q000627:therapeutic use*; D003606:Dacarbazine / Q000627:therapeutic use*; D006801:Humans; D008214:Lymphocytes / Q000502:physiology*; D008545:Melanoma / Q000188:drug therapy / Q000276:immunology* / Q000601:surgery; D008875:Middle Aged; D012397:Rosette Formation
D001500:BCG Vaccine; D003606:Dacarbazine