Chemotherapy and chemoprophylaxis of Angiostrongylus malaysiensis infection in rats with levamisole and mebendazole.
The chemoprophylactic and chemotherapeutic effects of levamisole and mebendazole on Angiostrongylus malaysiensis infection in rats were studied. Both drugs were ineffective in preventing infection while the post-infection treatment showed 100% efficacy. Furthermore, levamisole and mebendazole when given in combination appeared to have an antagonistic effect.
D000284:Administration, Oral; D000801:Angiostrongylus; D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D007978:Levamisole / Q000008:administration & dosage / Q000627:therapeutic use*; D008463:Mebendazole / Q000008:administration & dosage / Q000627:therapeutic use*; D009349:Nematode Infections / Q000188:drug therapy* / Q000517:prevention & control; D051381:Rats
D001562:Benzimidazoles; D007978:Levamisole; D008463:Mebendazole