Tetrocarcins E1, E2, F and F-1, new antibiotics. Fermentation, isolation and characterization.
New components of tetrocarcins (E1, E2, F and F-1) were found in the culture broth of Micromonospora chalcea KY 11091 that was known to produce tetrocarcins A, B and C. Tetrocarcin F-1 consisted of tetronolide and nitro sugar (tetronitrose). Tetrocarcins E1 and E2 consisted of F-1 and deoxy sugar (L-digitoxose). Tetrocarcin F consisted of F-1 and two deoxy sugars (their structures were not yet determined). They all showed antibacterial activities against Gram-positive bacteria and the specific activity decreased with decrease in the numbers of deoxy sugars attached to the aglycone.
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology; D008847:Micromonospora / Q000378:metabolism*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D006027:Glycosides; C035943:tetrocarcin F-1; C035942:tetrocarcin F; C035940:tetrocarcin E(1); C035941:tetrocarcin E(2)