title: Effects of tiapamil on haemodynamics and myocardial salvage during myocardial infarction in the baboon.
abstract: We studied the effects of tiapamil during myocardial infarction in the anaesthetized baboon. 10 animals received placebo and 8 animals the drug. After basal measurements the left anterior descending coronary artery was ligated. Measurements were repeated at 15 min and 2-hourly until the 12th h after occlusion. Placebo or drug (1 mg X kg-1 and 50 micrograms X kg-1 X min-1) was administered 20 min after occlusion. Tiapamil decreased afterload by reducing peripheral resistance. Blood flow to the peripheral ischaemic zone was increased. These effects resulted in myocardial salvage manifest as a reduction in serum creatine kinase (MB) isoenzyme levels and less myocardial damage at 12 h than that predicted for the placebo group by S-T segment mapping 15 min after occlusion.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003402:Creatine Kinase / Q000097:blood; D006439:Hemodynamics / Q000187:drug effects*; D007527:Isoenzymes; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism; D010215:Papio; D011437:Propylamines / Q000494:pharmacology*; D013976:Tiapamil Hydrochloride; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D002121:Calcium Channel Blockers; D007527:Isoenzymes; D011437:Propylamines; D003402:Creatine Kinase; D013976:Tiapamil Hydrochloride