Vitamin B6 reduces cortisone-induced cleft palate in the mouse.
Administration of Vitamin B6 during gestation to mice on a Vitamin B6-containing diet resulted in a substantial reduction in cortisone-induced cleft palate. Mice maintained on a Vitamin B6-deficient diet demonstrated an increase in the frequency of cortisone-induced cleft palate; this effect was prevented by administration of Vitamin B6. Vitamin B6 inhibited the specific binding of a labeled glucocorticoid to cytosolic receptors from cultured palatal mesenchyme cells. These results indicate that Vitamin B6 reduces the incidence of cortisone-induced cleft palate by altering the binding of glucocorticoids to their cytoplasmic receptors and subsequently nuclear acceptors.
D000014:Abnormalities, Drug-Induced / Q000517:prevention & control; D000818:Animals; D002478:Cells, Cultured; D002972:Cleft Palate / Q000139:chemically induced / Q000517:prevention & control*; D003348:Cortisone / Q000037:antagonists & inhibitors* / Q000633:toxicity; D005260:Female; D007700:Kinetics; D008297:Male; D051379:Mice; D011247:Pregnancy; D011736:Pyridoxine / Q000494:pharmacology*; D011965:Receptors, Glucocorticoid / Q000187:drug effects
D011965:Receptors, Glucocorticoid; D011736:Pyridoxine; D003348:Cortisone