title: Atropine and glycopyrrolate: changes in cardiac rate and rhythm in conscious and anaesthetised children.
abstract: Heart rate and rhythm were studied in conscious children and children under nitrous oxide and halothane anaesthesia following intravenous administration of atropine or glycopyrrolate. Both drugs produced a similar increase in heart rate when the potency of glycopyrrolate is considered twice that of atropine. There is no difference in the response of anaesthetised and awake children. Junctional rhythm is the main dysrhythmia observed which appears to occur more frequently in anaesthetised children. The administration of both drugs is safe in paediatric patients.
mesh_terms: D000293:Adolescent; D000375:Aging; D000768:Anesthesia, General; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D001285:Atropine / Q000009:adverse effects*; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D006024:Glycopyrrolate / Q000009:adverse effects*; D006221:Halothane; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007223:Infant; D011229:Preanesthetic Medication; D011759:Pyrrolidines / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D011759:Pyrrolidines; D001285:Atropine; D006221:Halothane; D006024:Glycopyrrolate