[Evaluation of the ototoxicity of aminoglycosides. Comparative study of dibekacin, gentamicin and tobramycin].
Various techniques useful for the precise functional and morphological evaluation of the auditory and vestibular systems in the guinea pig are described. Their application in the comparative study of the ototoxicity of three aminoglycosidic antibiotics (gentamicin, tobramycin and dibekacin) administered at doses of 90 mg/kg/day for 20 consecutive days is presented. In these conditions a severe cochlear impairment was observed with gentamicin and tobramycin while it was minimal with dibekacin. Vestibular impairment was also severe with gentamicin and definite, although less important, with dibekacin and tobramycin.
D000617:Aminoglycosides / Q000009:adverse effects; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D003982:Dibekacin / Q000009:adverse effects; D005069:Evaluation Studies as Topic; D005839:Gentamicins / Q000009:adverse effects; D006168:Guinea Pigs; D006801:Humans; D007759:Labyrinth Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D014031:Tobramycin / Q000009:adverse effects
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D003982:Dibekacin; D014031:Tobramycin
L'évaluation de l'ototoxicité des aminoglycosides. Comparaison de la dibékacine avec la gentamicine et la tobramycine.