Phencyclidine-induced decrease of methionine-enkephalin levels in mouse brain.
The effects of acute administration of phencyclidine (PCP) on the steady state levels of methionine-enkephalin in discrete brain areas were investigated in mice. The methionine-enkephalin levels in the medulla oblongata-pons and the midbrain were decreased by the administration of PCP. However, PCP induced no change of the methionine-enkephalin levels in other brain areas at the dose range of 5-20 mg/kg. These results suggest that the pharmacological effects of PCP may involve changes in enkephalinergic neuronal activity.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D003864:Depression, Chemical; D004744:Enkephalin, Methionine / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010622:Phencyclidine / Q000494:pharmacology*; D013997:Time Factors
D004744:Enkephalin, Methionine; D010622:Phencyclidine