Induction of bladder cancer in mice by implanting pellets containing tryptophan pyrolysis products.
A high incidence of transitional cell carcinomas were induced in the bladder of mice by bladder implantation of pellets containing crude tryptophan pyrolysate and the pyrolysis products, 3-amino-1,4-dimethyl-5H-pyrido-[4,3-b]indole (Trp-P-1) and 3-amino-methyl-5H-pyrido[4,3-b]indole (Trp-P-2), which are highly mutagenic substances.
D000818:Animals; D002243:Carbolines / Q000494:pharmacology*; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced*; D005260:Female; D007211:Indoles / Q000494:pharmacology*; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D019736:Prostheses and Implants; D014364:Tryptophan / Q000378:metabolism / Q000494:pharmacology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
D002243:Carbolines; D007211:Indoles; C019133:3-amino-1-methyl-5H-pyrido(4,3-b)indole; D014364:Tryptophan; C019132:3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole