The polymorphism of acetylcholinesterase in different animal species and motor innervation.
Acetylcholinesterase in the muscles of birds and mammals has several molecular forms with the same catalytic activity; these forms can be distinguished by their macromolecular properties. The presence of such asymmetric forms as A12 (triple tetramer with a collagen-like tail) is related to motor nerve functioning. Although, contrary to rat, they are always detected in nerve-free samples of chicken muscle, these asymmetric forms disappeared after various muscles of adult chicken and rabbit were denervated in our experiments. They appear in bird embryos at the time when the neuromuscular contacts are formed. The existence of asymmetric forms may depend on the contractile activity of muscle fibers and thus on the functioning of motor innervation. They could be good indicators of neuromuscular interactions.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D002642:Chick Embryo / Q000378:metabolism* / Q000502:physiology; D002645:Chickens / Q000378:metabolism* / Q000502:physiology; D005260:Female; D007527:Isoenzymes / Q000378:metabolism*; D009046:Motor Neurons / Q000502:physiology*; D009121:Muscle Denervation; D009132:Muscles / Q000201:enzymology* / Q000294:innervation; D011110:Polymorphism, Genetic; D011817:Rabbits / Q000378:metabolism* / Q000502:physiology; D013045:Species Specificity
D007527:Isoenzymes; D000110:Acetylcholinesterase