Impact of the anticoagulant-preservative citrate-phosphate-adenine (CPDA-1) on blood services.
The introduction of CPDA-1, as opposed to CPD, has allowed blood banks to store red blood cells for up to 35 days. The Missouri-Illinois Regional Blood Services studied the impact of CPDA-1 in three areas: reduction in blood outdating, change in distribution pattern, and the potential increase in the age of the products transfused. Our eighteen month study showed a reduction in blood outdating from 7.9 per cent to 3.9 per cent. Additionally, each unit of blood was distributed less frequently (from an average of 1.21 to 1.08 times from collection to transfusion). At the same time there was only a small increase in the mean age of the products transfused. It is our conclusion that the benefits of CPDA-1 can be attained with limited impact on the age of the products transfused.
D000225:Adenine / Q000494:pharmacology*; D000925:Anticoagulants / Q000378:metabolism*; D001771:Blood Banks / Q000458:organization & administration*; D001793:Blood Preservation; D002951:Citrates / Q000494:pharmacology*; D003451:Cryoprotective Agents / Q000378:metabolism*; D004905:Erythrocyte Aging / Q000187:drug effects; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D010710:Phosphates / Q000494:pharmacology*
D000925:Anticoagulants; C034876:CPDA solutions; D002951:Citrates; D003451:Cryoprotective Agents; D010710:Phosphates; D005947:Glucose; D000225:Adenine