Analog computer simulation of maternal - fetal transfer of cefazolin.
Cefazolin concentration-time data after normal vaginal delivery were obtained for maternal serum, placenta, umbilical cord blood, and amniotic fluid. After normalizing of the data, concentration-time profiles were generated for each sampling compartment. A pharmacokinetic model for analog computer simulation was developed. Multiple dosing simulation suggests a higher accumulation of cefazolin in fetal than in maternal blood, and a slow accumulation in amniotic fluid, which acts as a depot or storage. The drug is transferred diaplacentally; paraplacental transfer seems to be absent for cefazolin.
D000653:Amniotic Fluid / Q000032:analysis; D002437:Cefazolin / Q000097:blood / Q000378:metabolism*; D003202:Computers, Analog; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D007700:Kinetics; D008431:Maternal-Fetal Exchange; D008954:Models, Biological; D011247:Pregnancy; D013997:Time Factors
D002437:Cefazolin