Trimethoprim, metioprim, tetroxoprim, and RO 10-5970 in canine bone.
The penetration of trimethoprim and three derivatives into bone tissue was investigated in a dog model. Our data demonstrated that the trimethoprim derivative RO 10-5970 concentrates well in bone tissue with median tissue-to-serum concentration ratios of 0.23 in cortical bone and 0.81 in both medulla and cancellous bone. The use of RO 10-5970 in osseous infections is appealing because oral administration is possible; therefore, clinical trials appear warranted.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D004285:Dogs; D008297:Male; D011743:Pyrimidines / Q000378:metabolism*; D014295:Trimethoprim / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism*
D011743:Pyrimidines; C023507:tetroxoprim; D014295:Trimethoprim; C036263:metioprim; C037079:brodimoprim