Danazol and oral anticoagulants.
A case report of overt bleeding in a young woman on warfarin given the anabolic steroid danazol for menorrhagia is reported. This interaction appears to be poorly recognised and we suggest that when commencing such a treatment the dose of anticoagulant should initially be halved and thereafter tailored to the thrombotest.
D000284:Administration, Oral; D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D001780:Blood Coagulation Tests; D003613:Danazol / Q000009:adverse effects*; D004347:Drug Interactions; D005260:Female; D006417:Hematuria / Q000139:chemically induced*; D006801:Humans; D008595:Menorrhagia / Q000188:drug therapy; D011245:Pregnadienes / Q000009:adverse effects*; D011655:Pulmonary Embolism / Q000188:drug therapy; D014859:Warfarin / Q000009:adverse effects
D000925:Anticoagulants; D011245:Pregnadienes; D014859:Warfarin; D003613:Danazol