title: N-nitrosation of secondary amines by nitric oxide via the 'Drago complex'.
abstract: Diethylamine (DEA) and nitric oxide (NO) form a stable 1:1 complex (DEA/NO) which can be oxidized to N-nitrosodiethylamine (NDEA). Spectroscopic data for the complex are consistent with the ionic structure originally proposed by Drago & Paulik (1960). Attempts to confirm this structure by X-ray crystallography are continuing. Oxidation of DEA/NO to NDEA appears to be effected by an acid-catalysed dissociation to DEA and NO, followed by autoxidation of NO to an N-nitrosating higher oxide of nitrogen.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D004048:Diethylamines; D004052:Diethylnitrosamine / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D009569:Nitric Oxide; D009602:Nitrosamines / Q000138:chemical synthesis*; D010084:Oxidation-Reduction
chemical_list: D004048:Diethylamines; D009602:Nitrosamines; D009569:Nitric Oxide; D004052:Diethylnitrosamine