[Mutagenic effect of polycyclic aromatic hydrocarbons (PAH) and polar organic compounds (POC) in urban aerosols].
The concentrations of the polycyclic aromatic hydrocarbons (PAH) and the polar organic fraction (polar organic compounds = POC) as part of the aerosol particles, collected on fiberglass filters with a six-stage high volume cascade impactor from 17.7. to 9.10. 1981 from Berlin (West) air, were determined.--The two fractions were tested for their mutagenicity by using the Salmonella typhimurium bioassay (Ames-test). According to their site of deposition in the human respiratory system the aerosol particles were fractioned into two classes: "A" (Dae = 1.3-10.2 microns) and "B" (Dae = 0.4-1.3 microns). The following data were obtained: 1. The ether extractable organic matter (EEOM) contains 8.9-12.0% PAH and 40.1-65.8% POC. 2. PAH and POC extracted from particles with a Dae:1.3-10.2 microns exhibit nearly the same mutagenic activity after metabolic activation whereas the POC derived from particles with a Dae:0.4-1.3 microns (lung penetrating fraction) result in a higher mutagenicity than the PAH. 3. The POC show a higher mutagenic activity without metabolic activation than the PAH. 4. Generally extracts derived from particles with a Dae:0.4-1.3 microns exhibit higher mutagenic effects than those derived from particles with a Dae:1.3-10.2 microns.
D000336:Aerosols; D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D001604:Berlin; D001711:Biotransformation; D009152:Mutagenicity Tests; D009153:Mutagens; D011083:Polycyclic Compounds / Q000494:pharmacology*; D051381:Rats
D000336:Aerosols; D000393:Air Pollutants; D009153:Mutagens; D011083:Polycyclic Compounds
Untersuchungen zur mutagenen Wirksamkeit von polycyclischen aromatischen Kohlenwasserstoffen (PAH) und polaren organischen Verbindungen (POC) im Stadtaerosol.