Endorphin mediation of post-ictal effects of kindled seizures in rats.
Brief electrical stimulation of the enkephalin-rich globus pallidus at 1-h intervals produced kindled, clonic seizures in rats as rapidly as similar stimulation of the amygdala. Massing the kindling trials at 10-min intervals inhibited the occurrence of subsequent seizures, especially following globus pallidus stimulation. Naloxone (20 mg/kg), an opiate receptor antagonist, reversed this post-ictal inhibition of seizures following massed trials, but had no effect on seizures kindled at 1-h intervals. Thus, endorphin-released during seizures do not appear to mediate the production of kindled seizures, but do appear to mediate the transient posts ictal inhibition of seizures.
D000679:Amygdala / Q000502:physiology; D000818:Animals; D004745:Enkephalins / Q000502:physiology*; D005917:Globus Pallidus / Q000502:physiology; D007696:Kindling, Neurologic / Q000187:drug effects; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000502:physiology; D012640:Seizures / Q000378:metabolism*
D004745:Enkephalins; D009270:Naloxone