[Clometacin--1. Metabolism and bioavailability of clometacin and its metabolites in the rat].
The metabolism and bioavailability of 14C clometacin was studied in the rat. The drug is rapidly excreted in the urine and in the feces. It is not detected in any tissues of the treated animals 48 hours after administration. The metabolism of clometacin is very limited under the experimental conditions used in our study. More than 85% of the drug is excreted in an unchanged from. One metabolite, representing 4 to 10% of the excreted radioactivity, was found in the urine and identified as 1-(2-methyl-3-p-chloro phenylcarbinol-6-hydroxy) indol acetic acid. This metabolite was not detected in the feces, nor in the different tissues 4 or 48 hours after i.v. or oral administration of the drug.
D000818:Animals; D001682:Biological Availability; D005243:Feces / Q000032:analysis; D007210:Indoleacetic Acids / Q000378:metabolism* / Q000652:urine; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D007210:Indoleacetic Acids; C017136:clometacin
Travaux sur la clométacine--1re partie. Métabolisme et biodisponibilité de la clométacine et de ses métabolites chez le rat.