Response of mature mice to challenge with neuroblastoma after inoculation with neuroblastoma cells as neonates.
Injection (s.c.) of 2 X 10(5) S20Y neuroblastoma cells into adult A/J strain mice regularly produced a higher incidence of progressive, lethal tumor growth. In contrast, successful tumor growth was significantly less frequent (P less than 0.001) when the same number of tumor cells were injected into neonatal A/J mice. A significant number (P less than 0.001) of matured mice that had rejected the initial S20Y cell inoculum as neonates were able to reject 2 subsequent challenges with S20Y cells.
D000818:Animals; D000831:Animals, Newborn; D002460:Cell Line; D002999:Clone Cells; D007114:Immunization; D051379:Mice; D008805:Mice, Inbred A; D009374:Neoplasms, Experimental / Q000276:immunology; D009439:Neuraminidase / Q000494:pharmacology; D009447:Neuroblastoma / Q000276:immunology*
D009439:Neuraminidase