Tetraploid conceptus with three paternal contributions.
Cytogenetic and biochemical polymorphisms have been used to determine the origin of a tetraploid conceptus. Genetic polymorphisms were found in chromosomes 1, 6, 9, 15, 16, 22 and the sex chromosomes. The conceptus was found to have one maternal and three paternal contributions, indicating an origin other than a failure of cytokinesis at the first cleavage division of the zygote. The results presented are in favour of a trispermic origin of the conceptus.
D000328:Adult; D002900:Chromosomes, Human, 1-3 / Q000648:ultrastructure; D002901:Chromosomes, Human, 13-15 / Q000648:ultrastructure; D002902:Chromosomes, Human, 16-18 / Q000648:ultrastructure; D002904:Chromosomes, Human, 21-22 and Y / Q000648:ultrastructure; D002906:Chromosomes, Human, 6-12 and X / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007621:Karyotyping; D011110:Polymorphism, Genetic; D011123:Polyploidy; D011247:Pregnancy; D012730:Sex Chromosomes / Q000648:ultrastructure; D015053:Zygote / Q000648:ultrastructure*