Effect of linoleic acid on digitalis cardiotoxicity.
Adult male guinea pigs were anesthetized, catheterized and i.v. infused with either saline and then ouabain or with linoleic acid salt and then ouabain. The linoleic acid pretreatment produced a significant delay until the onset of digitalis induced cardiac arrhythmias.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D002301:Cardiac Glycosides / Q000633:toxicity*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D008041:Linoleic Acids / Q000494:pharmacology*; D008297:Male; D010042:Ouabain / Q000633:toxicity
D002301:Cardiac Glycosides; D008041:Linoleic Acids; D010042:Ouabain