Uterotropic effect of clofibrate and phenylbutazone in immature female rats.
The uterotropic effect of clofibrate and phenylbutazone was studied in immature female rats. A significant increase in the uterine wet weight was observed following clofibrate and phenylbutazone administration. Clofibrate but not phenylbutazone synergized with the uterotropic effect of ethinyl-oestradiol. Phenylbutazone pretreatment significantly decreased the pentobarbitone sleeping time. The uterotropic effect of clofibrate and phenylbutazone might involve displacement of 17-beta oestradiol (or ethinyl oestradiol) from plasma albumin binding sites in rats.
D000818:Animals; D002994:Clofibrate / Q000494:pharmacology*; D004357:Drug Synergism; D004967:Estrogens; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D009929:Organ Size / Q000187:drug effects; D010424:Pentobarbital / Q000037:antagonists & inhibitors; D010653:Phenylbutazone / Q000494:pharmacology*; D051381:Rats; D012890:Sleep / Q000187:drug effects; D014599:Uterus / Q000187:drug effects*
D004967:Estrogens; D004997:Ethinyl Estradiol; D010653:Phenylbutazone; D002994:Clofibrate; D010424:Pentobarbital