[Structural and functional status of the adrenergic innervation of the terminal portions of the vascular bed in experimental hypercholesterolemia].
The structural and functional status of adrenergic component of innervation of terminal microvessels was studied in total film preparations of the serous membranes (mesentery, pericardium) by the Falck-Owman fluorescent-histochemical method during simulation of experimental hypercholesterolemia in rabbits. It was revealed that in transitory hypercholesterolemia, the adrenergic structures primarily located along the course of the arteriolar part of the microcirculatory bed (MCB) manifested irreversible changes in their functional activity. In steady and constantly growing hypercholesterolemia, there occurred marked structural and functional changes in the adrenergic innervation of both the arteriolar and venular parts of the MCB, as well as in that of non-vascular areas of the serous membranes. This may evidence the damaging action of the blood risk factor, hypercholesterolemia, on the neuroreceptor endings of the terminal regions of the vascular bed.
D000818:Animals; D004036:Diet, Atherogenic; D006937:Hypercholesterolemia / Q000503:physiopathology*; D008297:Male; D008643:Mesentery / Q000294:innervation*; D008833:Microcirculation / Q000294:innervation / Q000503:physiopathology; D008856:Microscopy, Fluorescence; D010496:Pericardium / Q000294:innervation*; D011817:Rabbits; D011941:Receptors, Adrenergic / Q000502:physiology*; D013997:Time Factors
D011941:Receptors, Adrenergic
Strukturno-funktsional'noe sostoianie adrenergicheskoĭ innervatsii terminal'nykh otdelov sosudistogo rusla pri éksperimental'noĭ giperkholesterinemii.