Effect of increased fibrinolytic activity of rats blood on the action of some centrally acting drugs.
The action of some centrally acting drugs during high fibrinolytic activity of blood was studied. In these state the action of amphetamine increases and the action of thiopental and pentetrazol decreases. The observed changes may depend either on the altered pharmacokinetics of the compounds examined or on the neurohormonal background of the nervous tissue, changed under the influence of physical strain.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole / Q000494:pharmacology; D005082:Physical Exertion; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects; D013874:Thiopental / Q000494:pharmacology
D011619:Psychotropic Drugs; D005340:Fibrinogen; D000661:Amphetamine; D013874:Thiopental; D010433:Pentylenetetrazole