title: The metabolism of 1-phenyl-2-(N-methyl-N-benzylamino)propane (benzphetamine) in vivo in the rat.
abstract: 1. The metabolism of 1-phenyl-2-(N-methyl-N-benzylamino)propane (benzphetamine) was studied in vivo in the rat. 2. Nine metabolites were obtained from urine after oral administration of benzphetamine to rats. The major metabolite, identified as 1-(p-hydroxyphenyl)-2-(N-benzylamino)propane, was formed by aromatic hydroxylation and N-demethylation. One of the minor metabolites was methamphetamine, formed by N-debenzylation. 3. Metabolites excreted in three days after administration of the drug amounted to about 40% of the dose.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001589:Benzphetamine / Q000652:urine*; D001711:Biotransformation; D002849:Chromatography, Gas / Q000379:methods; D002855:Chromatography, Thin Layer; D008297:Male; D013058:Mass Spectrometry; D010627:Phenethylamines / Q000652:urine*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010627:Phenethylamines; D001589:Benzphetamine