Platelet function and fibrinolytic activity following distance running.
6 long distance runners from the Danish marathon elite and 6 non-runners completed test runs of 28 and 12 km, respectively. Distance runners and non-runners showed the same responses in platelet function. We found a significant decrease in ADP induced platelet aggregability, a decreased serotonin release induced by ADP and collagen and an increase in platelet factor 4 immediately following the run. The antithrombin III levels remained constant. Euglobulin lysis time was shortened (by approximately 50%) and the plasminogen levels significantly increased. The last 2 findings indicate an equal increase in fibrinolytic activity during distance running in both groups. While short term, strenuous exercise induces platelet hyperaggregation, long term distance running induces a state of exhaustion of platelet aggregation capacity.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D010978:Platelet Factor 4 / Q000032:analysis; D010979:Platelet Function Tests; D012420:Running; D012701:Serotonin / Q000097:blood; D013997:Time Factors
D012701:Serotonin; D010978:Platelet Factor 4; D000244:Adenosine Diphosphate