[Morphological and functional changes in the reticuloendothelial system in psoriatics].
99mTc-HSA-MM proved to be a valuable agent for both bone marrow visualisation and exploration of the phagocytic and proteolytic function of the RES-macrophages in psoriatic patients. 24 psoriatics and 24 normal healthy adults were examined. 18 (75%) of the psoriatics studied demonstrated peripheral extension of the bone marrow space, whereas this phenomenon could not be observed in normal subjects. The phagocytic and proteolytic turnover of 99mTc HSA-MM in liver, spleen and bone marrow was found to be accelerated in 66% (n = 12) of the systemically untreated persons. Six psoriatics treated systemically with aromatic retinoid for a longer period showed 2x a delayed and 4x a normal turnover; three patients with cirrhosis of liver showed in each case a delayed turnover of HSA-MM - Human Serum Albumin-Millimicrospheres.
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012157:Mononuclear Phagocyte System / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011565:Psoriasis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011877:Radionuclide Imaging
Morphologische und funktionelle Untersuchungsbefunde am Retikulo-endothelialen System bei Psoriatikern.