[Effect of calcium and magnesium on parathyroid hormone release from human parathyroid tissue in vitro].
The effects of calcium and magnesium on parathyroid hormone release from eight adenomas causing primary hyperparathyroidism and six hyperplastic glands causing hypercalcemic secondary hyperparathyroidism were investigated in vitro using single cell suspensions from the respective tissue. We observed suppression of parathyroid hormone release with increasing concentrations of either cation. The quantitative hormone secretions of both adenomatous and hyperplastic glands was identical.
D000236:Adenoma / Q000378:metabolism; D002118:Calcium / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006961:Hyperparathyroidism / Q000209:etiology / Q000378:metabolism*; D006962:Hyperparathyroidism, Secondary / Q000378:metabolism; D006965:Hyperplasia; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology*; D010280:Parathyroid Glands / Q000378:metabolism* / Q000473:pathology; D010281:Parathyroid Hormone / Q000378:metabolism*; D010282:Parathyroid Neoplasms / Q000378:metabolism
D010281:Parathyroid Hormone; D008274:Magnesium; D002118:Calcium
Effekt von Calcium und Magnesium auf die Parathormonfreisetzung aus humanem Parathyreoidea-Gewebe in vitro.