Familial intra-areolar polythelia with mammary hypoplasia.
Dysplastic divided nipples (intra-areolar polythelia) have been found bilaterally in a mother, her two daughters and one son. Two of the patients had mammary hypoplasia, one had unilateral hypoplasia of the pectoral muscle and duplication of the renal pelvis and ureter. The mammary findings are consistent with autosomal dominant inheritance. Whether they represent a new mammo-renal syndrome is uncertain. Reconstructive surgery was performed on two patients. Due to the deformity the mother was unable to nurse her children; following reconstructive surgery the daughter was able to feed her baby normally.
D000328:Adult; D001940:Breast / Q000002:abnormalities*; D001941:Breast Diseases / Q000235:genetics* / Q000601:surgery; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D008297:Male; D009558:Nipples / Q000002:abnormalities* / Q000601:surgery; D010375:Pedigree; D013518:Surgery, Plastic