[Feasibility of the in vitro evaluation of bioavailability. 3: Method of operation of a newly-developed absorption model and results obtained with it].
In connection with the function of a newly constructed absorption model the problem of interpretation of values obtained by models in regard of bioavailability is discussed. Wrong interpretations can be obtained if nonanalogous values are compared. An interpretation is proposed to calculate a value which is analogous to the relative bioavailability (calculated bioavailability). The efficiency of the absorption model and of the interpretation method is demonstrated by three examples of preparations of phenytoin, digoxin and chloramphenicol. We compared these results with the bioavailability of these preparations and we found a good correspondence.
D000042:Absorption; D001682:Biological Availability; D002701:Chloramphenicol / Q000378:metabolism; D004077:Digoxin / Q000378:metabolism; D006207:Half-Life; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010672:Phenytoin / Q000378:metabolism
D004364:Pharmaceutical Preparations; D010672:Phenytoin; D002701:Chloramphenicol; D004077:Digoxin
Möglichkeiten zur in-vitro-Beurteilung der Bioverfügbarkeit. 3: Mitteilung: Funktionsweise eines neu konstruierten Resorptionsmodells und damit erhaltene Ergebnisse.