title: Studies on uterine tract infections and the IUCD with special reference to actinomycetes.
abstract: Since the advent of the plastic IUCD, an increasing number of patients with clinical pelvic actinomycosis have been reported in the literature and in a very much larger number of women, actinomycetes have been identified in cervical smears, either by Papanicolaou stain or specific immunofluorescence. After a 3-year study, we have concluded that actinomycetes can readily be cultured when the growth of more rapidly growing anaerobes is inhibited by metronidazole and anaerobic culture is continued for up to 14 days. We consider that actinomycetes form part of a polymicrobial anaerobic infestation developing in the presence of a foreign body. The organisms are found almost exclusively in women who have used all-plastic IUCDs for a long term and, from a continuing study, it is apparent that most disappear rapidly when the plastic device is removed or replaced by a copper device. Significant symptomatic evidence of infection is found in a small proportion of patients who are actinomycete-positive.
mesh_terms: D000192:Actinomycetales / Q000302:isolation & purification; D000193:Actinomycetales Infections / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D002584:Cervix Uteri / Q000382:microbiology; D005260:Female; D005547:Foreign Bodies / Q000150:complications; D006801:Humans; D007435:Intrauterine Devices, Copper / Q000009:adverse effects*; D010969:Plastics / Q000009:adverse effects; D012189:Retrospective Studies; D014591:Uterine Diseases / Q000382:microbiology*
chemical_list: D010969:Plastics