[Granulocyte migration in vitro in psoriasis patients induced by aromatic retinoid].
The influence of the aromatic retinoid Ro 10-9359 on the migration of neutrophilic granulocytes was examined in standardized supravital preparation. For this purpose, leukocytes were taken from 5 psoriasis patients who had been treated with 75 mg of aromatic retinoid for 3 weeks. The examinations showed that the course of granulocyte migration was disturbed: the dormant stage was prolonged up to several hours. Maximum cell motility was already reached in that stage of motion in which the granulocytes maintained a constantly changing and bizarre cell pattern. The migration stage, which is characterized by a directed linear cell movement, was absent. Leukocyte survival time was shortened by 50%, and cell degeneration was abnormal under the influence of the aromatic retinoid.
D002464:Cell Migration Inhibition; D005050:Etretinate / Q000627:therapeutic use*; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology; D014212:Tretinoin / Q000031:analogs & derivatives*
D014212:Tretinoin; D005050:Etretinate
Granulozyten-Migration in Vitro bei Psoriasis-Patienten unter aromatischem Retinoid.