[Experimental model of the early stages of alimentary obesity in the rat].
Male rats have been fed a diet containing 50% butter by energy value and 1% cholesterol for 7 months to obtain an experimental obesity. Histological studies of different organs have revealed pronounced degenerative changes in the liver and adipose tissue, disturbed elasticity of the aorta and coronary, kidney and spleen arteries. Parallel biochemical investigations detected a rise in the activity of lysosomal phospholipases A in adipose tissue, in the liver, kidneys, and spleen. The most remarkable morphological and biochemical changes occurred in hepatocytes and adipocytes, which might be relatively regarded as target cells, the most sensitive to unbalanced fatty component of the diet.
D000273:Adipose Tissue / Q000201:enzymology / Q000473:pathology*; D000818:Animals; D001011:Aorta / Q000473:pathology; D004032:Diet; D004195:Disease Models, Animal; D007668:Kidney / Q000201:enzymology / Q000473:pathology; D008099:Liver / Q000201:enzymology / Q000473:pathology*; D008297:Male; D009765:Obesity / Q000201:enzymology / Q000473:pathology*; D010740:Phospholipases / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000201:enzymology / Q000473:pathology; D013997:Time Factors
D010740:Phospholipases; D010741:Phospholipases A
Eksperimental'naia model' nachal'nykh stadiĭ alimentarnogo ozireniia u krys.