title: Studies on the pulmonary capillary permeability after induced microembolism.
abstract: Pulmonary microembolization was induced by infusion of thrombin during inhibition of the fibrinolytic system. After embolization cardiac output decreased, pulmonary vascular resistance and pulmonary arterial pressure increased. There was a transient decrease in PaO2. Immediately after embolization there was an increased permeability indicated by tremendous increase in lymph flow with a constant lymph/plasma protein ratio. The lymph/plasma ratio for hemoglobin and for FITC-Dextran (mw 150 000) also increased indicating leakage of large molecules. The increased permeability was accompanied by a significant increase in extra-vascular lung-water as measured both with the thermal conductivity and the dry/wet weight method.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001834:Body Water; D002199:Capillary Permeability / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D005260:Female; D008168:Lung / Q000502:physiology*; D008196:Lymph / Q000187:drug effects; D008297:Male; D010313:Partial Pressure; D011652:Pulmonary Circulation / Q000187:drug effects; D011655:Pulmonary Embolism / Q000503:physiopathology*; D012119:Respiration / Q000187:drug effects; D013917:Thrombin / Q000494:pharmacology; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D013917:Thrombin