Consequences of the chronic cutaneous application of iodinated antiseptics on the thyroid function in the guinea-pig.
The effect of the chronic cutaneous application of iodine-containing substances on the thyroid function was studied in the guinea-pig. Six iodinated products were daily applied at the rate of 2 g/kg/day for 90 days. We find a quasi-abolition in the thyroid 131I-uptake (reflecting the transcutaneous absorption of free iodine) and an important transient thyroidal hyperproduction during the first month. Then, this primary hyperthyroidism induces a strong pituitary negative feed-back so that the levels of the circulating hormones T3 and T4 are normalized at the end of the experiment; a new hormonal balance is reached with a TSH level reduced by half compared to its normal value.
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D007455:Iodine / Q000008:administration & dosage / Q000494:pharmacology*; D007457:Iodine Radioisotopes / Q000378:metabolism; D010902:Pituitary Gland / Q000033:anatomy & histology; D013961:Thyroid Gland / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014285:Triiodothyronine, Reverse / Q000097:blood
D000891:Anti-Infective Agents, Local; D007457:Iodine Radioisotopes; D014284:Triiodothyronine; D014285:Triiodothyronine, Reverse; D013972:Thyrotropin; D007455:Iodine; D013974:Thyroxine