title: Dietary factors in relation to the etiology of colorectal cancer.
abstract: A case control study of 542 cases of colorectal cancer, 542 neighborhood controls, and 535 hospital controls has been conducted in two areas of Canada. The consumption of 13 nutrients has been estimated individually for all study members using an extensive diet history questionnaire. Highly significant dose-response relationships are observed between saturated fat intake and increased risk of both colon and rectal cancer for both sexes. In contrast no increase in risk was observed for intake of any level of polyunsaturated fat. The data are thus supportive of the hypothesis that dietary saturated fats may be of etiologic significance in cancers of the large bowel.
mesh_terms: D003110:Colonic Neoplasms / Q000139:chemically induced*; D004041:Dietary Fats / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D009749:Nutrition Surveys; D012004:Rectal Neoplasms / Q000139:chemically induced*; D012306:Risk
chemical_list: D004041:Dietary Fats