Effect of tryptophan on the production of mucidin in cultures of basidiomycete Oudemansiella mucida.
Addition of L-tryptophan to cultures of the basidiomycete Oudemansiella mucida brought about a pronounced increase of production of the antibiotic mucidin. The highest increase was reached in the presence of 0.15-0.20% tryptophan and after its addition to a l-d culture. The methyl ester of tryptophan exhibited the same effect. Mycelium growing during the initial phases in the presence of tryptophan synthesized mucidin powerfully during later phases of the fermentation.
D000475:Alkenes / Q000096:biosynthesis; D000935:Antifungal Agents / Q000096:biosynthesis*; D001487:Basidiomycota / Q000187:drug effects / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated; D008689:Methacrylates; D000073739:Strobilurins; D014364:Tryptophan / Q000494:pharmacology*
D000475:Alkenes; D000935:Antifungal Agents; D005231:Fatty Acids, Unsaturated; D008689:Methacrylates; D000073739:Strobilurins; C008556:mucidin; D014364:Tryptophan