A repeated dose study of the toxicity of CR applied to the skin of mice.
Dibenz (b,f)-1-4 oxazepine (CR) was applied to the skin of C3H and Porton-strain mice, daily for 12 weeks. After a further 80 weeks the animals were sacrificed and examined grossly and histologically. The results were compared with appropriate solvent and untreated controls. No abnormalities were found that could be ascribed to CR, but a high incidence of fatty infiltration of the liver in 1 strain of mice might have been due to the solvent in which CR was dissolved, namely acetone. There were marked differences in the incidence of several lesions in the 2 strains of mice, alveologenic carcinoma being much more common in the Porton mice. CR appeared to have little effect on the skin but both the test and solvent groups of male Porton mice shared an increased incidence of acanthosis.
D000818:Animals; D002273:Carcinogens; D003989:Dibenzoxazepines / Q000633:toxicity*; D005234:Fatty Liver / Q000139:chemically induced; D005260:Female; D007509:Irritants; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D012737:Sex Factors; D012882:Skin Tests
D002273:Carcinogens; D003989:Dibenzoxazepines; D007509:Irritants; C036433:dibenz(b,f)(1,4)oxazepine