Structure-activity relationships of some technetium-99m labeled [(thioethyl)amino] carboxylates.
The synthesis, NMR studies, radiochemical labeling with technetium-99m, and tissue-distribution characteristics of some [(thioethyl)amino] carboxylates are described. The 99mTc agents prepared were eliminated either by the urinary of the hepatobiliary system of mice. The excretion route of the 99mTc complexes was influenced by the structure and total charge of the ligands.
D000603:Amino Acids, Sulfur / Q000138:chemical synthesis* / Q000378:metabolism; D000818:Animals; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D013329:Structure-Activity Relationship; D013667:Technetium / Q000138:chemical synthesis* / Q000378:metabolism; D014018:Tissue Distribution
D000603:Amino Acids, Sulfur; D013667:Technetium