Tricyclic antidepressant effects on the murine lymphocyte mitogen response.
Tricyclic antidepressant binding sites have recently been detected on the membranes of murine splenic lymphocytes (1). It is reported here that the mitogenic response of murine lymphocytes is altered in the presence of tricyclic antidepressants at concentrations of 10(-5) M or greater. The time-dependent effects of these drugs, when added to the cultures at various times up to 24 hours subsequent to addition of a mitogen (either concanavalin A or lipopolysaccharide B), are also reported.
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001665:Binding Sites / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D066298:In Vitro Techniques; D008070:Lipopolysaccharides / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects*; D051379:Mice; D008934:Mitogens / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology
D000929:Antidepressive Agents, Tricyclic; D008070:Lipopolysaccharides; D008934:Mitogens; C036757:lipopolysaccharide B; D003208:Concanavalin A