[In vitro effect of polyestradiol on lecithin: cholesterol acyltransferase in rat blood].
The in vitro effect of increasing amounts of polyestradiol on LCAT activity was measured in plasma of male and female rats. The results showed that the hormone decreased the enzyme activity in both sexes. The concentration of polyestradiol required for this inhibitory effect was greater in male than in female plasma. No correlation was found between LCAT activity and polyestradiol concentration.
D000818:Animals; D002788:Cholesterol Esters / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008297:Male; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000037:antagonists & inhibitors / Q000097:blood*; D011108:Polymers / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D002788:Cholesterol Esters; D011108:Polymers; D004958:Estradiol; C022271:polyestradiol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase
Efecto in vitro del poliestradiol sobre la actividad lecitina: colesterol aciltransferasa en plasma de rata.