Effect of orally administered hydrocortisone on the rate of aqueous flow in man.
We studied the possible influence on the rate of aqueous flow of peroral hydrocortisone in 8 normal eyes of 8 normal subjects by means of fluorophotometry. In the control period, the mean value of ko obtained was 0.011 +/- 0.0023 min, where ko was the loss coefficient from the anterior chamber. On another day (hydrocortisone trial period), fluorophotometry was again performed after giving a dose of oral hydrocortisone (80 mg) and the mean value of ko obtained was 0.020 +/- 0.0027/min. The mean difference in ko values between the control period and the hydrocortisone trial period was significant (P less than 0.001). An increased rate of aqueous flow after giving a dose of oral hydrocortisone was demonstrated.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D001082:Aqueous Humor / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005470:Fluorometry; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010783:Photometry
D006854:Hydrocortisone