[Pharmacokinetics of ampicillin in children with respiratory infections].
The pharmacokinetics of ampicillin was studied in 30 children with diseases of the upper respiratory tracts. The data obtained with a single administration of anhydrous ampicillin in a dose of 25 mg/kg were estimated on one-compartment model. It was shown that the maximum antibiotic levels in the serum were attained in 1.52 hours and averaged to 4.56 micrograms/ml. The antibiotic half-life was 1.24 hours. The period of half-absorption of the antibiotic was 0.66 hours. Comparison of the experimental results with the literature data showed that the pharmacokinetic properties of anhydrous ampicillin and ampicillin trihydrate were close.
D000667:Ampicillin / Q000378:metabolism* / Q000627:therapeutic use; D001682:Biological Availability; D002648:Child; D002675:Child, Preschool; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D013997:Time Factors
D000667:Ampicillin
Farmakokinetika ampitsillina u deteĭ s respiratornymi infektsiiami.