[Some theoretical principles of aging research and its use in the aging of arteries. B. The aging of the arterial wall].
Processes of ageing on blood vessels can be made understandable only when special characteristics of structure and function of the artery are known and when a methodology is used which corresponds to these features. In these cases not only a reduction of structural elements are the results, but also qualitative alterations in the composition of fibres and of the basic substance as well as a cell proliferation of the area of the intima. The process of ageing in the arterial wall proceeds discontinuously and with local accentuation. Particularly weighty is the changing of the collagen and glycosaminoglycan synthesis which is dealt with in detail. In cooperation of cells, fibres and basic substance in the arterial wall exists a "micromilieu", the condition of which intensely influences the process of ageing. Influences of ageing on the side of the entire organism are, of course, mentioned in the present paper, but not treated in detail.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D000818:Animals; D001158:Arteries / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003094:Collagen / Q000378:metabolism; D004547:Elastic Tissue / Q000473:pathology; D004549:Elastin / Q000378:metabolism; D004727:Endothelium / Q000473:pathology; D006025:Glycosaminoglycans / Q000378:metabolism; D006801:Humans; D007223:Infant; D008854:Microscopy, Electron; D008875:Middle Aged; D009119:Muscle Contraction; D009124:Muscle Proteins / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000473:pathology*; D010446:Peptide Fragments / Q000378:metabolism
D006025:Glycosaminoglycans; D009124:Muscle Proteins; D010446:Peptide Fragments; D003094:Collagen; D004549:Elastin
Uber einige theoretische Grundlagen der Alternsforschung und ihre Anwendung auf das Altern der Arterien. B. Das Altern der Arterienwand.