Action of clofoctol on bacterial cell wall synthesis.
Clofoctol inhibits in vivo cell wall synthesis of B. subtilis and gives rise to an accumulation of UDP-N-acetyl-muramyl pentapeptide. However, in vitro peptidoglycan synthesis using a particulate membrane preparation is not inhibited by clofoctol. These results suggest that clofoctol does not inhibit a specific enzyme of the cell wall synthesis, and that the inhibition of the cell wall synthesis might be a secondary effect due to a disturbance of the cytoplasmic membrane.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000378:metabolism; D002473:Cell Wall / Q000187:drug effects* / Q000378:metabolism; D002722:Chlorobenzenes; D003408:Cresols / Q000494:pharmacology; D010457:Peptidoglycan / Q000378:metabolism; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D002722:Chlorobenzenes; D003408:Cresols; D010457:Peptidoglycan; D014640:Vancomycin; C018874:clofoctol