Disturbances of sleep and cognitive functioning in patients with dementia.
The relationship of sleep, circadian rhythms, and cognitive impairment in dementia patients is briefly reviewed. All-night sleep EEG data were collected in relatively young and relatively unimpaired patients with presumptive Alzheimer's disease and eight age-matched controls. Delta sleep time and Delta sleep % (Stages 3 and 4)--but not REM sleep measures--were significantly reduced in the patients. Implications of these findings are discussed.
D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology*; D002940:Circadian Rhythm; D003072:Cognition Disorders / Q000209:etiology* / Q000503:physiopathology; D003704:Dementia / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012890:Sleep / Q000502:physiology; D012894:Sleep Stages / Q000502:physiology; D012893:Sleep Wake Disorders / Q000209:etiology* / Q000503:physiopathology; D012895:Sleep, REM / Q000502:physiology