[Inhibition of respiration of mitochondria by o-phenanthroline in a constant magnetic field].
Preincubation of mitochondria treated with chelator of non-heme ferrum o-phenanthroline (0,067-0,267) for 20 min at 18 degrees C in the constant magnetic field of 330 mT brings about a decrease of the intensity of their uncoupled respiration with NAD-dependent substrates by 15-20% as compared to similar mitochondria preparations without the magnetic field effect. The latter is not realized during conjugated respiration with NAD-dependent substrates at uncoupled respiration with succinate, and in the absence of o-phenanthroline as well.
D000818:Animals; D007700:Kinetics; D008280:Magnetics; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D010618:Phenanthrolines / Q000494:pharmacology*; D051381:Rats
D010618:Phenanthrolines; C025205:1,10-phenanthroline
Ingibirovanie dykhaniia mitokhondriĭ o-fenantrolinom v postoiannom magnitnom pole.