title: Arylazido aminopropionyl atp (ANAPP3) antagonism of cat urinary bladder contractions.
abstract: ANAPP3 produces a transient contraction of the urinary bladder of the cat similar to that produced by ATP and hypogastric nerve stimulation. 2 ANAPP3 partially antagonizes the inhibition of pelvic nerve-evoked bladder contractions induced by adenosine, possibly by blocking P1 receptors. 3 ANAPP3 antagonizes contractions of the cat urinary bladder induced by ATP, beta, gamma-methylene ATP, pelvic nerve stimulation and hypogastric nerve stimulation. 4 ANAPP3 produces no antagonism of either noradrenaline-induced inhibition of pelvic nerve-evoked bladder contractions or acetylcholine-induced bladder contractions, thereby substantiating the specificity of the effect of ANAPP3 against purines.
mesh_terms: D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000494:pharmacology; D000345:Affinity Labels / Q000494:pharmacology*; D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology*; D001386:Azides; D002415:Cats; D005260:Female; D007001:Hypogastric Plexus / Q000502:physiology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D001743:Urinary Bladder / Q000187:drug effects / Q000294:innervation / Q000502:physiology*
chemical_list: C012761:3'-O-(3-(N-(4-azido-2-nitrophenyl)amino)propionyl)adenosine-5'-triphosphate; D000345:Affinity Labels; D001386:Azides; D000255:Adenosine Triphosphate