Membrane stabilization and inhibition of lipid peroxidation by anti-inflammatory indoles.
Nine 2-aryl-3-[4-(substituted phenyl)-3-thiosemicarbazone] indoles were evaluated for their ability to protect the human erythrocyte membrane against hypo-osmotic hemolysis and inhibit lipid peroxidation in rat liver homogenate in vitro. All compounds caused membrane stabilization and inhibition of lipid peroxidation when tested at final concentrations of 5 X 10(-4) and 2.5 X 10(-5) mol/l, respectively. These biochemical effects were not related to the anti-inflammatory property exhibited by the compounds.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D007211:Indoles; D008054:Lipid Peroxides