Enflurane blood-gas solubility: influence of weight and hemoglobin.
The blood-gas partition coefficient of enflurane was measured in nine nonobese and eight morbidity obese patients and correlated with weight, body mass index, and blood hemoglobin. The enflurane blood-gas partition coefficient was lower in the obese patients than in nonobese patients (mean +/- SEM: 2.03 +/- 0.02 versus 1.76 +/- 0.03, respectively, p less than 0.025). There was a negative correlation between enflurane blood solubility and both body mass index and weight (r = 0.59 and -0.55, respectively, p less than 0.01). A positive correlation was found between hemoglobin and the enflurane blood-gas partition coefficient (r = 0.69, p less than 0.01). Equilibrium between inspired and alveolar enflurane concentration should be faster in morbidity obese and anemic patients than in healthy, nonobese patients.
D000328:Adult; D001835:Body Weight; D004737:Enflurane / Q000097:blood*; D005740:Gases / Q000097:blood*; D006221:Halothane / Q000097:blood; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D009765:Obesity / Q000097:blood; D012995:Solubility
D005740:Gases; D006454:Hemoglobins; D004737:Enflurane; D006221:Halothane