title: Effects of cortical spreading depression on hypothalamic thermosensitive neurons in the rat.
abstract: Effects of unilateral cortical spreading depression (CSD) on the activities of thermosensitive neurons in the ipsilateral preoptic area and anterior hypothalamus (PO/AH) were studied in urethane-anesthetized rats. When a single wave of CSD invaded the frontal cortex, 22 of 25 warm-units were inhibited and all the 13 cold-units were facilitated for 1.2 - 14.2 min. These altered activities of PO/AH thermosensitive neurons may explain, at least in part, the changes of thermoregulatory behaviors and metabolic heat production in the rat with a unilateral PO/AH lesion during CSD of contralateral frontal cortex.
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology; D013181:Cortical Spreading Depression; D007839:Functional Laterality; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000502:physiology*; D011301:Preoptic Area / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013696:Temperature