Electroencephalographic changes in the lateral septum complex following systemic administration of des-Tyr1 -alpha-endorphin, des-Tyr1-gamma-endorphin and haloperidol in rats.
The influence of systemically administered Des-Tyr1-alpha-endorphin (DT alpha E), Des-Tyr1-gamma-endorphin (DT gamma E) and haloperidol on electroencephalographic (EEG) activity of the lateral septum complex (LSC) and the frontal cortex was studied in male rats. DT alpha E (2 micrograms) significantly increased whereas DT gamma E (10 micrograms) significantly decreased the amounts of activity in the 5 Hz band. In addition, DT alpha E promoted production of 15-20 Hz activity, while DT gamma E decreased the amount of 20-30 Hz activity. EEG activity exhibited a marked variability which persisted throughout the recording session following administration of the peptides. Haloperidol markedly decreased the proportion of 10-15 Hz activity. The alterations in EEG of the frontal cortex were similar to those in LSC but less pronounced. The differences in the time course and frequency bands affected suggest that the effects of peptides and haloperidol on EEG activity of LSC are not mediated by the same mechanisms.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D004569:Electroencephalography; D004723:Endorphins / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D004723:Endorphins; D010446:Peptide Fragments; C018903:gamma-endorphin, des-Tyr(1)-; C024770:alpha-endorphin, des-Tyr(1)-; D006220:Haloperidol