[Toxicological and pharmacological properties of ubiquinone-9 and hexahydroubiquinone-4].
Experiments were made on random-bred and linear mice, Wistar rats, rabbits and dogs to examine pharmacological properties of ubiquinone-9 and hexahydroubiquinone-4. Both compounds (oily solutions) administered intraperitoneally, intragastrically and subcutaneously in single and multiple doses produced no changes in the behavior or status of the animals, which might have attested to their toxicity. They were found to exert a regulatory action on the central nervous system, decreasing its sensitivity to numerous narcotic and convulsant substances without appreciable effects on the blood, arterial pressure, ECG and diuresis. The main obstacle for comprehensive experimental study and application of these substances in medical practice lies in the absence of a perfect medicinal form.
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity*
D014451:Ubiquinone; C001341:hexahydroubiquinone-4
Toksikologicheskie i nekotorye farmakologicheskie svoĭstva ubikhinona-9 i geksagidroubikhinona-4.