Production of N-acetylisopenicillin N and isopenicillin N from Streptomyces tokunonensis sp. nov.
N-Acetylisopenicillin N was isolated from the culture broth of Streptomyces tokunonensis sp. nov., and identified from 1H NMR spectroscopy and release of L-alpha-aminoadipic acid by acid hydrolysis. In the course of this study, the specimen of penicillin N isolated from this strain was proved to contain a small amount of isopenicillin N by HPLC.
D000107:Acetylation; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D010406:Penicillins / Q000096:biosynthesis*; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D010406:Penicillins; C037257:N-acetylisopenicillin; C006414:penicillin N