In vitro effects of mercury-selenium compounds on enzymes.
In vitro effects of mercury-selenium compounds, as compared with mercurials, against glucose-6-phosphate dehydrogenase (G6PD), catalase and trypsin were studied. Inhibitory potencies of two mercury-selenium (Hg-Se) compounds, bis(methylmercuric) selenide (BMS), and a reaction product of HgCl2, Na2SeO3 and glutathione (GSH), were markedly weaker than those of their original mercurials, methylmercury and mercuric mercury, respectively.
D000818:Animals; D002374:Catalase / Q000037:antagonists & inhibitors; D002417:Cattle; D004791:Enzyme Inhibitors; D005954:Glucosephosphate Dehydrogenase / Q000037:antagonists & inhibitors; D005978:Glutathione / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008628:Mercury / Q000633:toxicity*; D012643:Selenium / Q000633:toxicity*; D014361:Trypsin Inhibitors
D004791:Enzyme Inhibitors; D014361:Trypsin Inhibitors; D005954:Glucosephosphate Dehydrogenase; D002374:Catalase; D008628:Mercury; D005978:Glutathione; D012643:Selenium