[Drug modification of contractions of fetoplacental vessels of bilaterally in vitro perfused human placentas].
Studies were conducted into the effects of 20 medicaments on contraction of fetoplacental vessels in human placenta with bilateral in vitro perfusion. The presence of alpha receptors in the foetal vessels was concluded from the latter's response to alpha mimetics and alpha blockers, whereas beta receptors and muscarinergic receptors were not recordable from blood vessels of the full-term placenta. Medicaments with established vasodilatating action caused vasodilatation also in fetoplacental vessels, with most intensive effects being recorded from application of aminophylline and nitrangin. Strong vascular contraction was recorded in response to prostaglandin F2 alpha. The same type of studies was applied to other medicaments of common use in obstetrics. The method may be an experimental contribution to therapeutic medication of patients with acute or chronic impairment of fetoplacental blood supply.
D001808:Blood Vessels / Q000187:drug effects; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D010477:Perfusion / Q000379:methods; D010920:Placenta / Q000098:blood supply / Q000187:drug effects*; D011247:Pregnancy; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents
Untersuchungen zur medikamentösen Beeinflussung des Kontraktionszustandes der fetalen Plazentagefässe an der in vitro beidseitig perfundierten menschlichen Plazenta.