[The intraneural endocrine cell--the starting point of the origin of carcinoid tumors?].
Endocrine cells are demonstrable by electron microscopy in the lamina propria of the appendix mucosa. They are always in direct contact with a nerve fibre. The endocrine cell (types EC1, and EC2) and the polyaxonal non-myelinated nerve fibres are separated from the interstitial connective tissue by a common continuous basal lamina. The term "ECZ-NF complex" is suggested by the author to describe this morphological and functional unit. The intraneural endocrine cells may be derived from neuroendocrine-programmed ectoblasts according to Pearse (1977). These intraneural endocrine cells may comprise an additional extraepithelial cellular part of the "diffuse neuroendocrine system". The electron microscopic demonstration of similarly structured "eZ-NF complexes" (polypeptide-producing endocrine cell and nerve fibre) in connection with the demonstration of small nerve fibres within carcinoids of appendix, caecum and rectum allows us to propose a hypothetical pathogenesis of gastrointestinal carcinoids from these intraneural endocrine cells.
D001065:Appendix / Q000648:ultrastructure; D002276:Carcinoid Tumor / Q000473:pathology*; D002432:Cecum / Q000648:ultrastructure; D002838:Chromaffin System / Q000648:ultrastructure*; D004759:Enterochromaffin Cells / Q000648:ultrastructure*; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology*; D009412:Nerve Fibers / Q000648:ultrastructure*; D012007:Rectum / Q000648:ultrastructure
Intraneurale endokrine Zelle--Ausgangspunkt der Karzinoidentstehung?