Teratogenesis and low copper status resulting from D-penicillamine in rats.
The teratogenicity of D-penicillamine was studied using the Sprague-Dawley rat. Fetuses from rats fed diets containing 0.83% D-penicillamine during pregnancy had a high incidence of malformations. Maternal and fetal tissue copper levels were significantly lower in the D-penicillamine group than in controls, suggesting that the teratogenicity of the drug may be due in part to the induction of copper deficiency by its chelating properties.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D003300:Copper / Q000172:deficiency*; D005260:Female; D010396:Penicillamine / Q000009:adverse effects*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D003300:Copper; D010396:Penicillamine