Hereditary lethal arthrogryposis ("muscle contracture") in horses.
In 4 female foals of the Norwegian horse breed, "Fjord Horse", congenital arthrogryposis of the limbs are described. The disorder was mainly limited to the hind limbs and associated with polydactylia and partly with brachygnathia superior and cleft palate. The defective foals were paternal halfsisters of 4 normal foals (1 female + 3 males), sired by the stallion "Bingo" 1804, which was phenotypically quite normal. The disorder being lethal, is possibly caused by a sex-limited or a strongly sex-influenced dominant gene.
D000015:Abnormalities, Multiple / Q000662:veterinary; D000818:Animals; D001176:Arthrogryposis / Q000150:complications / Q000235:genetics / Q000662:veterinary*; D002869:Chromosome Aberrations / Q000662:veterinary*; D025063:Chromosome Disorders; D005260:Female; D005799:Genes, Dominant; D006580:Genetic Carrier Screening; D006734:Horse Diseases / Q000235:genetics*; D006736:Horses; D008297:Male; D010375:Pedigree