title: Response of plasma catecholamines and blood pressure to clonidine and to sudden withdrawal of the drug in subjects with essential hypertension.
abstract: In this retrospective study in ten patients with essential hypertension a short-time treatment of 3 days with 0.15 mg clonidine 2 times/day orally, as well as a second short-term treatment period with the slow-release oral preparation (.025 mg clonidine once/day) significantly lowered blood pressure, heart rate, and plasma concentration of norepinephrine in the supine and standing subject. After sudden withdrawal of clonidine all these parameters returned to pretreatment levels within 2-3 days. No rebound or overshoot phenomenon was observed.
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002395:Catecholamines / Q000097:blood*; D003000:Clonidine / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000097:blood; D013375:Substance Withdrawal Syndrome / Q000097:blood / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D002395:Catecholamines; D003000:Clonidine; D009638:Norepinephrine