Mechanical properties of traumatized rat tendo-achilles and the effect of an anti-inflammatory drug on the repair properties.
This paper reports on the effect of orally administered flurbiprofen, a potent inhibitor of prostaglandin synthesis (cyclo oxygenase inhibitor), on the mechanical properties of traumatized rat tendo-achilles to see if the F2 alpha prostaglandin was affected and hence the repair process. The drug (1 mg) was administered daily for 7 days to 18 rats whose tendo-achilles were traumatized by crimping using a predetermined force (50 N) applied for 10s. Eighteen sham control rats were identically traumatized and given daily the same volume of liquid (water) not containing the drug. Forty non-traumatized, untreated rats were examined as controls. In vitro studies showed that there was no significant difference in the stress--strain and relaxation characteristics between the three groups and no histological differences were observed.
D000125:Achilles Tendon / Q000187:drug effects / Q000293:injuries*; D000818:Animals; D005480:Flurbiprofen / Q000494:pharmacology*; D008297:Male; D011422:Propionates / Q000494:pharmacology*; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013314:Stress, Mechanical; D013718:Tensile Strength; D014945:Wound Healing / Q000187:drug effects
D011422:Propionates; D011448:Prostaglandin Antagonists; D005480:Flurbiprofen