A simple radiobiological model for fractionated radiation therapy.
A new cell tissue kinetic model has been tested against rat skin data. A two parameter survival curve formula was used for cellular lethality and two or three further parameters correspond to simple relations for repopulation. The model does not depend on the level of tissue reaction, thus enabling us to predict the degree of reaction. Further improvements can be made by including changes in cell survival curve during irradiation, because of cell cycle effects. The model describes rat skin data much better than other methods having been proposed by various authors.
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D008433:Mathematics; D008954:Models, Biological; D011879:Radiotherapy Dosage; D051381:Rats; D012867:Skin / Q000528:radiation effects*