[Effects of therapy with a association of nifedipine and atenolol in patients with systemic arterial hypertension and angina pectoris].
16 patients suffering from hypertension and angina pectoris (class II according to the NYHA) are treated with 100 mg atenolol once daily for three weeks. A good decrease of the blood-pressure values and a clinical improvement of the anginous symptomatology are observed. The bicycle ergometer exercise test showed an increase of the effort tolerance. The addition of 30 mg nifedipine for other three weeks, decreased further on the values of the blood-pressure and of the double product. The ergometric exercise showed an increase of total work and of the maximum working capacity reached by patients. This association (atenolol + nifedipine) was particularly useful in patients who presented symptoms of intolerance toward other drugs (nitroderivate f. es.), because of less collateral effects and easy administration.
D000328:Adult; D000787:Angina Pectoris / Q000150:complications / Q000188:drug therapy*; D001262:Atenolol / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D011412:Propanolamines / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*
D011412:Propanolamines; D011725:Pyridines; D001262:Atenolol; D009543:Nifedipine
Effetti della terapia con l'associazione nifedipina-atenololo in soggetti con ipertensione arteriosa sistemica ed angina da sforzo.