Colchicine delays the estrogen-induced copulatory response in the ovariectomized female rat.
A study was made of the effect of colchicine on the lordotic response to estradiol benzoate (EB) plus progesterone in ovariectomized rats. Colchicine (0.5 + 0.25 mg/kg s.c.) given in connection with the EB treatment inhibited the response elicited by progesterone 24 or 48 h after administration of EB. In contrast, significantly more colchicine-treated animals responded when progesterone was given at 118 h. This increase in lordotic response occurred at a time when normally the response has declined. The response was not enhanced by the protein synthesis inhibitors anisomycin (50 mg/kg s.c.) or cycloheximide (1 mg/kg s.c.). The results suggest that an impairment of axonal transport by colchicine may lead to storage of lordosis-promoting products, which are released when the colchicine effect has worn off.
D000818:Animals; D000841:Anisomycin / Q000494:pharmacology; D001921:Brain / Q000187:drug effects; D002369:Castration; D003078:Colchicine / Q000494:pharmacology*; D003307:Copulation; D003513:Cycloheximide / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008870:Microtubules / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012726:Sexual Behavior, Animal / Q000187:drug effects
D009419:Nerve Tissue Proteins; D011374:Progesterone; D004958:Estradiol; D000841:Anisomycin; D003513:Cycloheximide; D003078:Colchicine