Dissociation of the enhancing effects of lead acetate on lethal and body-weight-decreasing activities of endotoxin by the administration route.
The enhancing effects of lead acetate on the lethal and the body-weight-decreasing activities of endotoxin in mice with different combinations of the administration routes. The effect of lead acetate on the lethality was shown by iv administration, but not by ip administration. The body-weight-decreasing activity of endotoxin was enhanced by ip administration of lead acetate but not by iv administration. In any case, the route of administration of endotoxin was not concerned with the enhancement by lead acetate.
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004357:Drug Synergism; D004731:Endotoxins / Q000633:toxicity*; D007854:Lead / Q000008:administration & dosage*; D051379:Mice; D009942:Organometallic Compounds
D004731:Endotoxins; D009942:Organometallic Compounds; D007854:Lead; C008261:lead acetate