Effect of trimethyltin on chemically-induced seizures.
The effect of trimethyltin (TMT; 4.26 mg/kg i.p.), at 1 and 14 h following administration, on chemically-induced seizures in mice is reported. At 1 h following administration, TMT decreased seizure responsiveness and protected animals from bicuculline, isonicotinic acid hydrazide (INH) and pentylenetetrazol (PTZ) induced seizures. At 14 h following administration, TMT provided little protection against bicuculline, INH or PTZ induced seizures. Only slight decreases in seizure responsiveness were observed with strychnine induced seizures at either 1 or 14 h. By 16 h following administration, animals exhibited spontaneous tremors and convulsions. The results indicate that TMT exerts a biphasic effect on central nervous system excitability.
D000818:Animals; D000927:Anticonvulsants; D001640:Bicuculline / Q000494:pharmacology; D007538:Isoniazid / Q000494:pharmacology; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D013331:Strychnine / Q000494:pharmacology; D013997:Time Factors; D014220:Trialkyltin Compounds / Q000494:pharmacology*; D014298:Trimethyltin Compounds / Q000494:pharmacology*
D000927:Anticonvulsants; D014220:Trialkyltin Compounds; D014298:Trimethyltin Compounds; D013331:Strychnine; D007538:Isoniazid; D010433:Pentylenetetrazole; D001640:Bicuculline