Dopaminergic activity of quipazine.
Rats were trained to discriminate between the stimulus properties of intraperitoneal 0.16 mg/kg apomorphine and saline in a two-lever, food-motivated operant task. Administration of 1.0 mg/kg quipazine, a putative serotonin agonist, produced apomorphine-appropriate responding with a maximal effect occurring at 45 min post-injection. Pretreatment with either 2.0 mg/kg methysergide or 0.4 mg/kg haloperidol reduced quipazine-induced responding upon the apomorphine-appropriate lever to levels observed with methysergide or haloperidol administered alone. These results evidence a dopaminergic action for quipazine and suggest that central serotonergic and dopaminergic pathways may interact cooperatively to control behavior.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D004192:Discrimination, Psychological / Q000187:drug effects; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology*; D011814:Quipazine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D013997:Time Factors
D011804:Quinolines; D011954:Receptors, Dopamine; D011814:Quipazine; D006220:Haloperidol; D001058:Apomorphine; D008784:Methysergide