title: Effect of Corynebacterium parvum on bone marrow macrophage colony production, peripheral blood leukocytes, and histologic changes of tissues in calves.
abstract: An IV injection of formalin-killed Corynebacterium parvum in calves did not cause a marked increase in the number of bone marrow macrophage colonies or peripheral blood monocytes, granulocytes, or lymphocytes. In treated calves, the spleen increased in weight and there were macrophage infiltrations in liver, lungs, spleen, and lymph nodes. Lymphoid hyperplasia was observed in bronchial-associated lymphoid tissue, cortical areas of the thymus, and in primary and secondary follicles and the paracortical area of lymph nodes.
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D002417:Cattle / Q000276:immunology*; D003114:Colony-Forming Units Assay; D005557:Formaldehyde / Q000494:pharmacology; D007958:Leukocyte Count / Q000662:veterinary; D007962:Leukocytes / Q000166:cytology*; D008099:Liver / Q000166:cytology; D008168:Lung / Q000166:cytology; D008264:Macrophages / Q000166:cytology*; D008297:Male; D009928:Organ Specificity; D011425:Propionibacterium acnes / Q000187:drug effects / Q000276:immunology*; D013154:Spleen / Q000166:cytology; D013950:Thymus Gland / Q000166:cytology
chemical_list: D005557:Formaldehyde