title: Multivariate response surface optimization.
abstract: A search strategy is proposed to find the best compromise among several extremes obtained from structure-activity relationships. The global optimum is established by evaluating the functions at the relative optimum points and selecting the most extreme of all solutions obtained. The example deals with the activity of rifamycin derivatives against a rifamycin-MS-resistant mutant of Staphylococcus aureus.
mesh_terms: D012044:Regression Analysis; D012294:Rifamycins / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D012294:Rifamycins