[Role of age in the interaction of tetracycline with the subcellular fractions of rat liver homogenate].
The effect of the rat age on the binding of tetracyclines to the subcellular fractions of liver homogenates was studied. The tetracyclines significantly lost their activity after the contact with the cell organoids. The level of the binding was lower in the newborn and old rats, the complex of tetracycline with mitochondria being less stable. The greater part of the antibiotic reduced its activity after washing of the organoids. The deposition of the antibiotics in the cells was the most pronounced in the pubertal animals.
D000375:Aging / Q000187:drug effects*; D000818:Animals; D000831:Animals, Newborn; D004347:Drug Interactions; D005260:Female; D008099:Liver / Q000187:drug effects*; D008297:Male; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D013347:Subcellular Fractions / Q000187:drug effects; D013754:Tetracyclines / Q000378:metabolism*
D013754:Tetracyclines
Vozrastnoĭ aspekt vo vzaimodeĭstvii tetratsiklinov s subkletochnymi fraktsiiami gomogenata pecheni krys.