[Ultrastructural and histochemical characteristics of embryonic hepatocytes exposed to ethanol].
The induction of ethanol (10 and 40% concentration) to pregnant female rats causes embryolethal effect, inhibition of fetus development, breaks morphofunctional state of embryo liver, causes hydropathic vacuolization of hepatic cells, lowering of DNA and RNA level in them, breaks penetrability of vascular walls. Ethanol causes antimitotic effect which depends on concentration and induces changes in hepatic cells ultrastructure (vacuolization of cytoplasm, appearance of megalomitochondria and others).
D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005865:Gestational Age; D006651:Histocytochemistry; D008099:Liver / Q000187:drug effects / Q000196:embryology / Q000648:ultrastructure*; D008112:Liver Glycogen / Q000378:metabolism; D008854:Microscopy, Electron; D008938:Mitosis / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D008112:Liver Glycogen; D000431:Ethanol
Ul'trastrukturnaia i gistokhimicheskaia kharakteristika émbrional'nykh gepatotsitov pri deĭstvii étanola.