AM-2604 A, a new antiviral antibiotic produced by a strain of Streptomyces.
A novel antibiotic, AM-2604 A was isolated from the fermentation broth of Streptomyces sp. AM-2604 by solvent extraction and silica gel column chromatography. The antibiotic is pale yellow needles possessing UV absorption maxima at 280 nm and 330 nm (sh). The antibiotic possesses weak activity against fungi and trichomonad and potent inhibitory activity against various RNA and DNA viruses in vitro.
D000818:Animals; D000900:Anti-Bacterial Agents; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology; D018942:Macrolides; D051379:Mice; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*; D014780:Viruses / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D007783:Lactones; D018942:Macrolides; C037255:virustomycin A