The effect of adrenalectomy on GDP binding to brown-adipose-tissue mitochondria of obese rat.
GDP binding to brown-adipose-tissue mitochondria of young obese Zucker rats (fa/fa) was significantly lower than in lean control rats, as a result of a decrease in the number of binding sites. Adrenalectomy of fa/fa rats restored GDP binding to control values. Corticosterone replacement suppressed GDP binding in adrenalectomized obese rats.
D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000315:Adrenalectomy; D000818:Animals; D001665:Binding Sites; D006150:Guanine Nucleotides / Q000378:metabolism*; D006153:Guanosine Diphosphate / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D009765:Obesity / Q000378:metabolism*; D051381:Rats; D011924:Rats, Zucker
D006150:Guanine Nucleotides; D006153:Guanosine Diphosphate