title: [Changes in lymphocytes caused by aldosterone and a spironolactone derivative. Animal experiments and clinical studies].
abstract: In animal experiments marked and characteristic changes of lymphocytes could be observed with electronmicroscopic methods due to aldosterone and potassium canrenoate. These results may be a further reference to an immunosuppressive effect of aldosterone and spirolactone derivates. The electronmicroscopic study of thoracic duct cells of a patient suffering from multiple sclerosis and treated with aldosterone and potassium canrenoate showed changes of the morphological structure of small lymphocytes, which was interpreted with a lymphoclastic effect of this substances on lymphocytes.
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000494:pharmacology*; D000818:Animals; D002191:Canrenoic Acid / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D008854:Microscopy, Electron; D011245:Pregnadienes / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013148:Spironolactone / Q000031:analogs & derivatives*
chemical_list: D011245:Pregnadienes; D013148:Spironolactone; D000450:Aldosterone; D002191:Canrenoic Acid
vernacular_title: Veränderungen der Lymphozyten durch Aldosteron und ein Spironolacton-Derivat.