Analysis of haloperidol tablets by high-performance liquid chromatography--an inter-laboratory study.
A high-performance liquid-chromatographic (HPLC) method for the determination of haloperidol in tablets was developed and evaluated by an inter-laboratory study. The spectrophotometric method of the British Pharmacopoeia 1973 was evaluated concurrently, and the accuracy and precision of the methods were compared. Two samples of a commercially available haloperidol tablet formulation were analysed by thirteen laboratories with satisfactory results for column performance and precision of assay. The total error standard deviations, SD, for the HPLC method and the spectrophotometric method were 3.92 and 2.58%, respectively. The HPLC method is considered suitable for official testing purposes.
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005069:Evaluation Studies as Topic; D006220:Haloperidol / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets / Q000032:analysis
D013607:Tablets; D006220:Haloperidol