Polyvinylpyrrolidone (povidone) storage in RX-damaged skin following procaine-povidone intramuscular injections.
A man, aged 67, has been treated in 1968 by X-rays for a basal-cell carcinoma of the back. The treatment was followed by an ulcerative radiodermatitis. 3 years later, the patient was treated by ten intramuscular injections of procaine-polyvinylpyrrolidone (or procaine-povidone) for sciatic neuralgia. An orange infiltration appeared progressively around the radiodermatitis. The area was excised in 1979 and polyvinylpyrrolidone (povidone) storage, responsible for the ring-shaped orange hue, could be demonstrated in the dermis and subcutaneous fat. Special stainings confirmed the presumed chemical nature of the deposits. 3 cases of povidone pseudotumours following procaine-povidone injections had been described previously. The preferential deposit of povidone in RX-damaged skin is discussed.
D000368:Aged; D002280:Basal Cell Carcinoma / Q000532:radiotherapy; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D011205:Povidone / Q000008:administration & dosage / Q000378:metabolism*; D011343:Procaine / Q000008:administration & dosage*; D011855:Radiodermatitis / Q000209:etiology / Q000378:metabolism*; D011878:Radiotherapy / Q000009:adverse effects*; D012867:Skin / Q000378:metabolism*; D012878:Skin Neoplasms / Q000532:radiotherapy; D012883:Skin Ulcer / Q000209:etiology / Q000378:metabolism*; D014964:X-Ray Therapy / Q000009:adverse effects*
D011343:Procaine; D011205:Povidone