Inhibition of lymphocytes by seminal plasma fractions from azo-, oligo- and normozoospermic men.
Human seminal plasma specimens from 62 patients were collected and divided into three groups according to their fertility state. Five protein peaks, obtained by column chromatography, were used in lymphocyte transformation studies to measure their effect on blast transformation rates. The results expressed as percentage inhibition showed that the immunosuppressive activity of isolated seminal plasma fractions were more marked than whole seminal plasma. There was no statistical correlation between inhibition caused by each fraction and the fertility state of the patient groups. Inhibitory components do not seem to relate to the amount of sperm cells in the ejaculate.
D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D009845:Oligospermia / Q000503:physiopathology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D012661:Semen / Q000378:metabolism*
D010835:Phytohemagglutinins