Inhibition of prolactin release by stimulation of presynaptic serotonin autoreceptors.
The effects of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), a serotonin agonist with a preferential action on presynaptic autoreceptors, on prolactin release in male rats was determined. Basal serum prolactin levels were not altered after administration of 1.0, 2.0, 5.0, 10.0 or 20.0 mg/kg of 5-MeODMT. Pretreatment with 5-MeODMT reduced prolactin release by agents that depend on serotonergic neurotransmission for part of their prolactin release stimulation. Prolactin release in response to L-5-hydroxytryptophan (5-HTP) or morphine was significantly reduced by pretreatment of the rats with 5-MeODMT. The results of this experiment indicate that 5-MeODMT acts as a presynaptic serotonin autoreceptor stimulant and not as a post-synaptic serotonin agonist on the neuronal systems that control prolactin release.
D000818:Animals; D001933:Brain Stem / Q000378:metabolism*; D003864:Depression, Chemical; D008297:Male; D008732:Methoxydimethyltryptamines / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D011388:Prolactin / Q000097:blood*; D011814:Quipazine / Q000494:pharmacology; D011903:Raphe Nuclei / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*
D008732:Methoxydimethyltryptamines; D010879:Piperazines; D011985:Receptors, Serotonin; C018406:1-(3-trifluoromethylphenyl)piperazine; D011814:Quipazine; D011388:Prolactin; C015068:1-(3-chlorophenyl)piperazine