title: [The influence of systemic digitalis application on intraocular pressure].
abstract: The intraocular pressure (IOP) of ten healthy subjects was measured before and after a 2-week systemic application of beta-methyldigoxin. The drug led to a highly significant decrease of IOP of on the average 2 mm Hg. The decrease was independent of the blood concentration of glycoside - at least within the therapeutic range. There was a positive correlation between IOP before digoxin application and the subsequent IOP decrease. The rate of outflow increased, but not significantly. Implications for the therapy of glaucoma are briefly discussed.
mesh_terms: D000328:Adult; D004070:Digitalis; D006027:Glycosides / Q000097:blood; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008520:Medigoxin / Q000494:pharmacology; D010946:Plants, Medicinal; D010947:Plants, Toxic
chemical_list: D006027:Glycosides; D008520:Medigoxin
vernacular_title: Zum Einfluss von systemischer Digitalis-Applikation auf den intraocularen Druck.