title: Delayed, relapsing experimental allergic encephalomyelitis in mice. Role of adjuvants and pertussis vaccine.
abstract: The effect was studied of varying the dosage of mycobacteria and pertussis vaccine in the immunization emulsion on the development of delayed, relapsing experimental allergic encephalomyelitis (DR-EAE) in SJL/J mice. DR-EAE could be induced with dosages of mycobacteria from 0.2 mg to 1.0 mg per mouse. Animals given pertussis vaccine from different batches and different sources all developed DR-EAE with similar percentages of animals sick, animals relapsing, and delay to onset. Mice immunized without pertussis vaccine also developed DR-EAE but had fewer relapses and a longer delay to onset. The role of antigens and adjuvants in relapsing EAE and analogies with multiple sclerosis are discussed.
mesh_terms: D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D005620:Freund's Adjuvant / Q000008:administration & dosage*; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D009103:Multiple Sclerosis / Q000276:immunology; D009161:Mycobacterium / Q000276:immunology; D010567:Pertussis Vaccine / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D012008:Recurrence; D013116:Spinal Cord / Q000276:immunology
chemical_list: D010567:Pertussis Vaccine; D005620:Freund's Adjuvant