[Effect of histone H5 on the development of virus-induced leukemia and RNA synthesis in leukemic cells].
Development of virus-induced Rauscher leukosis was studied after administration into mice of histone H5 isolated from chicken erythrocyte nuclei by means of gel filtration through Sephadex G-75. Histone H5, administered intraperitoneally at a dose of 100 mg/kg into mice treated with Rauscher virus, inhibited the leukosis development (T = 29.7%). Inhibitory effect of histone H5 on synthesis of 35S RNA, characteristic for leukemic cells, was found. The most distinct efficiency of the histone was exhibited within early periods of the infection in experimental animals.
D000818:Animals; D002645:Chickens; D004589:Electrophoresis, Disc; D004912:Erythrocytes / Q000032:analysis; D006657:Histones / Q000302:isolation & purification / Q000494:pharmacology*; D007942:Leukemia, Experimental / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D012334:RNA, Neoplasm / Q000096:biosynthesis*; D011925:Rauscher Virus; D013154:Spleen / Q000378:metabolism
D006657:Histones; D012334:RNA, Neoplasm
Vliianie gistona H5 na razvitie virusindutsirovannogo leĭkoza i sintez RNK leĭkoznykh kletok.