[Experimental studies on metastasis of carcinomas. Preliminary report].
By elimination of immune defenses, high doses of cortisone may cause precancerosis to degenerate into cancer. If cancer is already in existence, elimination of the immune defenses leads to a massive activation of the carcinoma, to anaplastic modification of the cancer cells, and to the most alarming development, the forming of metastases. These findings from the experiments performed show very clearly that the fate of cancer patients largely depends upon the reaction of local and general defenses. Further considerations demonstrate the importance of defense reactions in the pathogenesis of carcinomas and other malignant growths. It is concluded that research can only grasp the pathogenesis of carcinomas and other malignomas if--in a differentiated way--it concerns itself with the gradual diminution of the defense factors during the time of latency in the development of the malignant disease. It is in this context that we may find the possibility of therapeutic influence upon the development of cancer.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D003348:Cortisone / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D009362:Neoplasm Metastasis / Q000473:pathology*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D011230:Precancerous Conditions / Q000139:chemically induced; D011817:Rabbits; D012878:Skin Neoplasms / Q000473:pathology*
D003348:Cortisone
Experimentelle Untersuchungen zur Metastasierung von Karzinomen.