[Role of determination of creatine kinase isoenzyme MB in the diagnosis of myocardial lesions after surgery of the major vessels].
A considerable increase in CPK activity is usually noted after reconstructive surgery on thoracic and abdominal aorta and its branches (75 patients), MB-CPK activity being increased in 48.0% of the cases. Increased cumulative MB-CPK activity, pointing to the isoenzyme's withdrawal from the myocardium (3.2 to 5.6 Eq), was established in 8 patients. It was only in one case (1.3%) that a typical curve and a high cumulative activity of the isoenzyme (29.14 Eq) suggested the diagnosis of acute myocardial infarction. Therefore, increased MB-CPK activity alone cannot signal focal myocardial necrosis. Although the increase in cumulative MB-CPK activity correlates, to some degree, with negative ECG developments in the patients with basic coronary disease, it is only the typical curve and high MB-CPK activity that can be used as specific criteria in the enzymatic diagnosis of myocardial infarction after reconstructive surgery on main vessels.
D000328:Adult; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000601:surgery*; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000209:etiology; D011183:Postoperative Complications; D012306:Risk
D007527:Isoenzymes; D003402:Creatine Kinase
Znachenie opredeleniia izofermenta kreatinfosfokinazy MB v vyiavlenii povrezhdeniĭ miokarda posle operatsiĭ na magistral'nykh sosudakh.