title: [Regulation of PEP-carboxylase of the facultative methylotrop Acetobacter sp. MB 58].
abstract: Acetobacter sp. MB 58 assimilates methanol via the fructose-1,6-bisphosphate variant of the hexulose phosphate pathway. Glyceraldehyde-3-phosphate originates as net product of an assimilation loop involving the regeneration of the C1-acceptor ribulose-5-phosphate and must be available for the de novo synthesis of the C1-acceptor as well as for the oxidative glycolysis. It is made probable in a regulatory model that this is accomplished via alternating anabolic and catabolic phases which are controlled by concerted action of PEP-carboxylase and pyruvate kinase. Whereas Ac-CoA is a crucial effector and alpha-ketoglutarate and aspartate are inhibitors for the PEP-carboxylase, the pyruvate kinase is assumed to be regulated by energy charge.
mesh_terms: D000091:Acetobacter / Q000201:enzymology*; D000105:Acetyl Coenzyme A / Q000378:metabolism; D000227:Adenine Nucleotides / Q000494:pharmacology; D001224:Aspartic Acid / Q000494:pharmacology; D002262:Carboxy-Lyases / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007656:Ketoglutaric Acids / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D000432:Methanol / Q000378:metabolism*; D008954:Models, Biological; D010730:Phosphoenolpyruvate Carboxylase / Q000378:metabolism*; D011770:Pyruvate Kinase / Q000378:metabolism
chemical_list: D000227:Adenine Nucleotides; D007656:Ketoglutaric Acids; D001224:Aspartic Acid; D000105:Acetyl Coenzyme A; D011770:Pyruvate Kinase; D002262:Carboxy-Lyases; D010730:Phosphoenolpyruvate Carboxylase; D008274:Magnesium; D000432:Methanol
vernacular_title: Regulation der PEP-Carboxylase des fakultativ methylotrophen Acetobacter sp. MB 58.