Radical scavengers and the stability of 99mTc-radiopharmaceuticals.
It was found that compounds, such as ene-1,2-diols, diphenyl derivatives, and certain oxidants, are suited to prevent decomposition of 99mTc-radiopharmaceuticals. For effective stabilization of 99mTc(Sn)-DTPA different radioactive concentrations of 99mTcO-4 solution require different concentrations of stabilizers. As a possible reason for the decomposition of 99mTc-radiopharmaceuticals radicals are discussed. Superoxide anion or hydroperoxyl radicals are especially taken into consideration.
D004164:Diphosphonates; D004355:Drug Stability; D007553:Isotope Labeling / Q000379:methods; D004369:Pentetic Acid; D011933:Reagent Kits, Diagnostic; D013667:Technetium; D013669:Technetium Tc 99m Medronate; D016284:Technetium Tc 99m Pentetate / Q000031:analogs & derivatives*
D004164:Diphosphonates; D011933:Reagent Kits, Diagnostic; C034230:technetium Tc 99m-Sn-DTPA; C023568:technetium Tc 99m (Sn)methylenediphosphonate; D013667:Technetium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate; D013669:Technetium Tc 99m Medronate