Phosphate treatment of recurrent calcium stone disease.
A group of 38 male recurrent idiopathic calcium stone formers were treated with oral supplements of orthophosphate (1 g phosphorus extra in the diet per day) and followed at intervals up to 4 years. The urinary excretion of calcium decreased (p less than 0.001) and that of inorganic phosphate increased (p less than 0.001) during treatment. These changes resulted in a small decrease in the supersaturation of urine with respect to calcium oxalate, sufficient to reduce the percentage of urines which exceeded the upper limit of solubility of that salt, and a small increase in the supersaturation of urine with respect to calcium phosphate. The stone episode rate on treatment fell in 35 of the 38 patients from a mean pretreatment value of 0.66 episodes/year to 0.22 episodes/year. The 3 initially most prolific stone formers increased their rate of stone formation during treatment. Plasma biochemistry showed no evidence of parathyroid stimulation.
D002129:Calcium Oxalate / Q000652:urine*; D002130:Calcium Phosphates / Q000652:urine*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010710:Phosphates / Q000627:therapeutic use*; D012008:Recurrence; D013997:Time Factors; D014545:Urinary Calculi / Q000517:prevention & control* / Q000652:urine
D002130:Calcium Phosphates; D010710:Phosphates; D002129:Calcium Oxalate