The kinetics of phagocytosis of colloidal substances in experimental insulinopenic diabetes.
Because of a reduction in the rate of phagocytosis by the reticuloendothelial system, the removal of large doses of colloids from the blood is much slower in rats with experimentally induced insulinopenic diabetes than in controls having a normal metabolism. This kinetics corresponds to the exponential response reported in the literature for an injected dose exceeding the "critical dose", with phagocytosis being a crucial parameter. In the case of smaller doses of colloids, however, clearance follows a different kinetic pattern which is here formulated mathematically. It is determined largely by the rate of liver blood flow. In this case, it is not possible to obtain statistical evidence of differences between diabetic and normal rats on administration of gold. Colloidal gold and so-called biological ink proved themselves extremely useful for quantitative studies of phagocytosis, whereas indium proved to be unsuitable under the experimental conditions used in these studies.
D000818:Animals; D002244:Carbon; D003102:Colloids; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000175:diagnosis; D006050:Gold Radioisotopes; D007204:Indium; D007700:Kinetics; D008297:Male; D012157:Mononuclear Phagocyte System / Q000378:metabolism; D010587:Phagocytosis; D011868:Radioisotopes; D051381:Rats; D011919:Rats, Inbred Strains
D003102:Colloids; D006050:Gold Radioisotopes; D011868:Radioisotopes; D007204:Indium; D002244:Carbon