Endogenous synthesis of volatile nitrosamines: model calculations and risk assessment.
A kinetic model for estimating the gastric synthesis of N-nitroso compounds and a method for estimating the risk from exposure to volatile nitrosamines are described. A tentative calculation of the possible risks for human gastric cancer, based on extrapolating from literature data on the induction of tumours in rats, suggests that the endogenous formation of non-volatile N-nitroso compounds is more important than that of volatile nitrosamines.
D005504:Food Analysis; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008019:Life Style; D008954:Models, Biological; D009566:Nitrates / Q000032:analysis / Q000378:metabolism; D009573:Nitrites / Q000032:analysis / Q000378:metabolism; D009602:Nitrosamines / Q000378:metabolism* / Q000633:toxicity; D012306:Risk; D013274:Stomach Neoplasms / Q000139:chemically induced*; D013997:Time Factors
D009566:Nitrates; D009573:Nitrites; D009602:Nitrosamines