Elevation of thermoregulatory vasodilatation threshold in the rat after capsaicin treatment.
In control and capsaicin-treated (300 mg/kg) rats tail skin vasodilatation was studied while the body temperature was raised to 38 degrees C, 39 degrees C or 40 degrees C and held at these levels. In the capsaicin-treated rats, at 38 degrees C vasodilatation was weaker than in the controls but at temperatures of 39 degrees C and 40 degrees C a delayed increase in tail vasodilatation occurred to the level observed in the controls. It is concluded that the threshold of vasodilatation response to heat is elevated after capsaicin treatment.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D002211:Capsaicin / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D006358:Hot Temperature; D008297:Male; D051381:Rats; D012881:Skin Temperature / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects*
D005231:Fatty Acids, Unsaturated; D002211:Capsaicin