[Effect of chlorpromazine on adrenal secretion of corticosterone and pituitary secretion of prolactin].
1. The authors studied, in adult male and female rats the effect of one or repeated injections of chlorpromazine on adrenal secretion of corticosterone and pituitary secretion of prolactin. 2. Injections of chlorpromazine increased plasma corticosterone, plasma and pituitary prolactin. 3. The discussion of the results was correlated to the brain catecholamines postulated to be neurotransmitters involved in the control of corticotropin and prolactin pituitary secretion.
D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism; D002746:Chlorpromazine / Q000494:pharmacology*; D003345:Corticosterone / Q000378:metabolism*; D005260:Female; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002395:Catecholamines; D011388:Prolactin; D002746:Chlorpromazine; D003345:Corticosterone
Action de la chlorpromazine sur les sécrétions surrénalienne de corticostérone et hypophysaire de prolactine.