title: The acute toxicity of nonachloropredioxin and 3- and 4-hydroxynonachlorodiphenyl ether in mice.
abstract: The acute intraperitoneal LD50 values of hydroxynonachlorodiphenyl ethers (HO-Cl9-DPEs) in mice have been determined. The acute toxicity of each of these compounds is compared with that of pentachlorophenol (PCP) and 2-hydroxy-2',4,4'-trichlorodiphenyl ether (2-HO-Cl3-DPE; Irgasan DP-300; Triclosan), a commonly used bactericide. The order of acute toxicity observed was: 2-HO-Cl9-DPE greater than technical PCP approximately equal to pure PCP greater than 3-HO-Cl9-DPE greater than 4-HO-Cl9-DPE greater than 2-HO-Cl3-DPE. Symptomatology following exposure to the HO-Cl9-DPEs was similar to that observed for PCP, a known uncoupler of oxidative phosphorylation. 2-HO-Cl3-DPE, however, produced clinical signs suggestive of a suppressive effect on the central nervous system. Data on time response following a lethal dose of each of these compounds was also obtained.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D001419:Bacteria / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D055768:Halogenated Diphenyl Ethers; D007928:Lethal Dose 50; D051379:Mice; D008815:Mice, Inbred Strains; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010416:Pentachlorophenol / Q000633:toxicity; D010647:Phenyl Ethers / Q000633:toxicity*; D014260:Triclosan / Q000633:toxicity*
chemical_list: D000900:Anti-Bacterial Agents; D004785:Environmental Pollutants; D055768:Halogenated Diphenyl Ethers; D010647:Phenyl Ethers; C036958:4-hydroxynonachlorodiphenyl ether; C024879:nonachloropredioxin; C036957:3-hydroxynonachlorodiphenyl ether; D014260:Triclosan; D010416:Pentachlorophenol