Effects of cortisol administration on development of the thyroid and adrenal axes in rats.
Intraperitoneal (IP) injections of cortisol were administered to neonatal male rats on postnatal days 1 to 4. Plasma triiodothyronine (T3), thyroxine (T4) and corticosteroids were determined on days 5, 10, 13, 16, 20, 30 and 60 of age, and all animals were weighed weekly. Neonatal cortisol treatment resulted in depressed body weight gain and transient depression in plasma T4. These results indicate that while body weight is significantly affected by cortisol treatment ontogenic patterns of plasma T3, T4 and corticosteroids develop normally.
D000302:Adrenal Cortex / Q000254:growth & development*; D000305:Adrenal Cortex Hormones / Q000097:blood; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D003864:Depression, Chemical; D006854:Hydrocortisone / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000254:growth & development*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D000305:Adrenal Cortex Hormones; D014284:Triiodothyronine; D013974:Thyroxine; D006854:Hydrocortisone