Psoralen--long-wave ultraviolet therapy and human cataractogenesis.
Cataract formation associated with psoralen--long-wave ultraviolet (P-UVA) therapy has been documented in experimental animals. Presumptive P-UVA cataracts in humans have also been reported recently. Cataracts from two patients on P-UVA therapy were subjected to high-resolution phosphorescence spectroscopy. The lens homogenates from these two patients showed phosphorescence peaks identical (in shape and lifetime) with the previously reported 8-methoxypsoralen lens protein photoproduct seen in P-UVA-treated cataractous rat lenses. The data provide objective proof that these phototherapeutic drugs can generate specific P-UVA photoproducts in human lenses. Similar photoproducts have previously been demonstrated in experimental (rat) P-UVA cataracts.
D000328:Adult; D000818:Animals; D002386:Cataract / Q000209:etiology*; D004247:DNA / Q000032:analysis; D005136:Eye Proteins / Q000032:analysis; D006801:Humans; D008730:Methoxsalen / Q000032:analysis; D011701:PUVA Therapy / Q000009:adverse effects*; D010778:Photochemotherapy / Q000009:adverse effects*; D011835:Radiation Protection / Q000295:instrumentation; D051381:Rats; D012160:Retina / Q000032:analysis
D005136:Eye Proteins; D004247:DNA; D008730:Methoxsalen