Niridazole-induced biochemical changes in the rat testis.
A high dose of niridazole administered intraperitoneally (i.p.) to male rats over a period of 9 weeks induced alterations in the concentrations and activities of some important testicular constituents and enzymes, respectively. The concentrations of total and free cholesterol were higher than those of control animals but the concentration of esterified cholesterol was significantly lower than that of the control rats. Zinc concentration in the testis and prostate gland of niridazole-treated animals was significantly lower than in the control animals. Decreases in the activities of the following enzymes occurred in the testes of niridazole-treated rats: lactate and sorbitol dehydrogenases, aspartate and alanine aminotransferases and alkaline phosphatase. By contrast, there were increases in the activities of testicular malate dehydrogenase and prostate acid phosphatase of rats given niridazole.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism; D008297:Male; D009560:Niridazole / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000187:drug effects* / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
D002784:Cholesterol; D000469:Alkaline Phosphatase; D015032:Zinc; D009560:Niridazole