[Metabolic study of sarcoma 45 and Walker carcinosarcoma cells during the process of growth and exposure to anticoagulants (an enzyme cytochemical analysis)].
The enzyme activities of lactate dehydrogenase (LDH), succinate dehydrogenase (SDH) and acid phosphatase (AP) in the rat sarcoma 45 (S. 45) cells and Walker carcinosarcoma (WCS) cells were estimated from the histochemical study. No significant changes were found in the histochemical reaction intensity during the tumour growth but at the late stage of WCS growth the LDH activity increased. WCS metastases were distinguished by the elevated enzyme activity of LDH as compared with the tumour. During the anticoagulant treatment the LDH and SDH activity in S. 45 and WCS cells falls, but the AP activity increases.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects; D002279:Carcinoma 256, Walker / Q000188:drug therapy / Q000201:enzymology*; D006651:Histocytochemistry; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000201:enzymology*; D013385:Succinate Dehydrogenase / Q000378:metabolism
D000925:Anticoagulants; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D000135:Acid Phosphatase
Issledovanie metabolizma kletok sarkomy 45 i kartsinosarkomy Uoker v protsesse ikh rosta i pri antikoaguliantnom vozdeĭstvii (énzimotsitokhimicheskiĭ analiz).