[A Lead-containing lipomelanosis of the human nucleus dentatus cerebelli].
A case of a rare pigmentation of nucleus dentatus and stratum granulare cerebelli was investigated with microscopical and histochemical methods such as atom absorption and neutron activation analysis. The histochemical results of the analysis suggest that the pigment may belong to the group of melanin. The prepigments are rich in chromolipoids. The concentration of copper, zinc, iron and lead is increased. The larger content of lead has to be regarded as the very pathological symptom in the human cerebellum.
D000368:Aged; D002526:Cerebellar Diseases / Q000473:pathology*; D002531:Cerebellum / Q000648:ultrastructure; D003300:Copper / Q000032:analysis; D005260:Female; D006801:Humans; D007501:Iron / Q000032:analysis; D007854:Lead / Q000032:analysis; D008055:Lipids / Q000032:analysis; D008548:Melanosis / Q000473:pathology*; D008854:Microscopy, Electron; D015032:Zinc / Q000032:analysis
D008055:Lipids; D007854:Lead; D003300:Copper; D007501:Iron; D015032:Zinc
Die Metallolipomelanose des Nucleus dentatus cerebelli des Menschen. Licht- und elektronenmikroskopische, histochemische, atomabsorptions-spectrometrische und neutronenaktivierungsanalytische Untersuchungen sowie Elektronenstrahl-Mikroanalyse.