Effects of compounds structurally related to 5,6-dihydroxytryptamine on behavior and brain biogenic amines in the rat.
A variety of analogues of the serotonin neurotoxin, 5,6-dihydroxytryptamine were administered to rats by injection into the lateral ventricle of the brain. Each compound evoked a unique pattern of behavioral effects. Only 5,6-dihydroxytryptamine lowered brain 5HT levels, while both 5,6-dihydroxytryptamine and its benzo[b]thiophene analogue caused a transient lowering of brain NE.
D015115:5,6-Dihydroxytryptamine / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001679:Biogenic Amines / Q000032:analysis*; D001923:Brain Chemistry / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis; D013329:Structure-Activity Relationship
D001679:Biogenic Amines; D012701:Serotonin; D015115:5,6-Dihydroxytryptamine