title: [Characteristics of the reproductive and immunogenic activity of influenza A viruses isolated in the 1977-1980 epidemic].
abstract: Regular studies of the biological properties of influenza A viruses on the model of little-passaged variants revealed some features of reproductive and immunogenic activity of this virus in the period of successive epidemics of 1969-1980. Unlike influenza A viruses of 1968-1976 with high immunogenic and reproductive activities, influenza A viruses isolated in the USSR during epidemics of 1977-1978, 1979, and 1980 were either poorly immunogenic and unable for reproduction in the throat after oral administration, or, like variants of 1979, intensively multiplied in the throat but did not spread actively into the nasal epithelium and produced no immunological protection in orally vaccinated humans. The possibility of using the model of little-passaged viruses for the study of changes in the biological properties of human influenza virus in the time course of its development is discussed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001831:Body Temperature; D002642:Chick Embryo; D004196:Disease Outbreaks; D006801:Humans; D007114:Immunization; D009980:Influenza A virus / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology*; D007252:Influenza Vaccines / Q000276:immunology; D007251:Influenza, Human / Q000382:microbiology*; D012137:Respiratory System / Q000382:microbiology; D013997:Time Factors; D014779:Virus Replication
chemical_list: D007252:Influenza Vaccines
vernacular_title: Kharakteristika reproduktsionnoĭ i immunogennoĭ aktivnosti virusov grippa A, vydelennykh v period épidemii 1977-1980 gg.