title: [Tumor prevention in xeroderma pigmentosum using aromatic retinoid (Ro 10-9359)].
abstract: Aromatic retinoid Ro 10-9359 1 mg/kg body weight was given to an 11-year-old girl with xeroderma pigmentosum. Therapy resulted in disappearance of actinic keratoses and basal cell carcinomas. The occurrence of new tumors could be prevented in this patient while she participated in this preventive therapy for 7 months. The reduction of the aromatic retinoid to 0.4 mg/kg body weight every other day resulted in the reappearance of four basal cell carcinomas an one keratoacanthoma within 6 weeks.
mesh_terms: D002648:Child; D005050:Etretinate / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D012878:Skin Neoplasms / Q000517:prevention & control*; D014212:Tretinoin / Q000031:analogs & derivatives*; D014983:Xeroderma Pigmentosum / Q000188:drug therapy* / Q000473:pathology
chemical_list: D014212:Tretinoin; D005050:Etretinate
vernacular_title: Tumorprophylaxe bei Xeroderma pigmentosum mit aromatischem Retinoid (Ro 10-9359).