title: Stimulation of NK-like CMC by skin test antigens in vitro is depressed in patients with SLE.
abstract: Peripheral blood mononuclear cells isolated from patients with systemic lupus erythematosus (SLE) developed lower levels of skin test antigen stimulated natural killer cell like cell-mediated cytolysis (NK-like CMC) than did similar cells from age and sex matched non-SLE volunteers. When the subjects were grouped according to disease activity the cells from the patients with mild disease activity developed lower levels of NK-like CMC than did those from the non-SLE control subjects. The cells isolated from SLE patients who had moderate to severely active disease developed little if any NK-like CMC after exposure to various skin test antigens. Greatly decreased skin test antigen stimulation of NK-like CMC in the cells from the SLE patients with more active disease did not appear to be due to therapy with corticosteroids or to a suppressor effect on this response by monocytes present in the peripheral blood mononuclear cell populations.
mesh_terms: D000328:Adult; D000368:Aged; D000941:Antigens / Q000276:immunology*; D002175:Candida / Q000276:immunology; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D012882:Skin Tests; D013299:Streptodornase and Streptokinase / Q000276:immunology
chemical_list: D000941:Antigens; D013299:Streptodornase and Streptokinase