Effect of antifibrinolysis treatment on human cancer in nude mice.
The effect of tranexamic acid on the growth of three human tumor cell lines (lung squamous cell carcinoma QG-56, lung adenocarcinoma PC-12 and ovarian carcinoma OC-1) was investigated in vitro and in vivo in nude mice. Tranexamic acid exhibited no direct cytotoxicity in vitro, but it inhibited the growth of all the three cell lines as tumors in nude mice. Prominent deposition of fibrin or fibrinogen around tumor cells at the advancing border were observed only in the tumors of treated animals.
D000818:Animals; D002460:Cell Line; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D005260:Female; D005337:Fibrin / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D008175:Lung Neoplasms / Q000032:analysis / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000032:analysis / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000032:analysis / Q000473:pathology; D014148:Tranexamic Acid / Q000494:pharmacology*; D014183:Transplantation, Heterologous
D003509:Cyclohexanecarboxylic Acids; D014148:Tranexamic Acid; D005337:Fibrin; D005340:Fibrinogen