[Hydrazide derivatives of fluorobenzoic acids and their antimicrobial activity].
The compounds of formula (A) were prepared by reaction between Rn-substituted benzoyl hydrazides and R-substituted benzoyl chlorides; the compounds of formula (B) were obtained by condensing R-substituted benzoyl chlorides with isonicotinic hydrazide. All the compounds were tested for in vitro activity against five Gram+ bacteria (S. aureus, S. epidermidis, B. subtilis, B. anthracis, M. paratuberculosis ATCC 607), seven Gram-bacteria (S. paratyphi A, S. paratyphi B, E. coli, B. abortus, B. melitensis, P. aeruginosa, P. mirabilis) and three fungi (C. albicans, A. niger, S. cerevisiae), by agar-diffusion method (Kirby-Bauer modified). The prepared compounds generally showed inhibitory activity against Gram+ bacteria. The greatest activity was observed in the compounds of general formula (B); they were especially inhibitory toward M. paratuberculosis ATCC 607.
D001419:Bacteria / Q000187:drug effects*; D001565:Benzoates / Q000494:pharmacology; D005464:Fluorobenzenes / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D006834:Hydrazines / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D001565:Benzoates; D005464:Fluorobenzenes; D006834:Hydrazines
Derivati idrazidici di acidi fluorobenzoici ad attivita' anti microbica.