Synthesis of [3H]- and -[14C]-labeled sulprostone.
The synthesis of N-methanesulfonyl 16-phenoxy-omega-tetranor PGE2 carboxamide (sulprostone--CP-34,089/ZK-57,671) labeled with tritium and carbon-14 is described. Sulprostone labeled with tritium in the phenoxy moiety by means of catalytic hydrogenolysis was obtained in a 17% radiochemical yield with a specific activity of 1.0 Ci/mmol. The methanesulfonamide-14C derivative of sulprostone was prepared from methyl-14C iodide in an 11.8% radiochemical yield having a specific activity of 18.8 mCi/mmol.
D002250:Carbon Radioisotopes; D055598:Chemical Phenomena; D002621:Chemistry; D015232:Dinoprostone / Q000031:analogs & derivatives*; D007553:Isotope Labeling / Q000379:methods*; D011459:Prostaglandins E, Synthetic / Q000138:chemical synthesis*; D014316:Tritium
D002250:Carbon Radioisotopes; D011459:Prostaglandins E, Synthetic; D014316:Tritium; C016767:sulprostone; D015232:Dinoprostone