Small accessory chromosomes (SAC) and their genotype--phenotype correlation.
A total of 39 carriers of small accessory chromosomes (SAC) was found among 32,930 patients karyotyped in Division of Human Genetics, Catholic University, Leuven, Belgium, in the years 1966-1981. In majority of SAC carriers the origin of extra-chromosome material remained unknown (21 out of 29 index patients), even when applying different banding techniques. The only common feature of all described SAC seems to be the presence of C-banded heterochromatin. The genotype-phenotype correlation in SAC carriers has been discussed.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000235:genetics* / Q000473:pathology; D002871:Chromosome Banding; D025063:Chromosome Disorders; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D010641:Phenotype