title: Regenerated middle ear mucosa after tympanoplasty.
abstract: The surgeon's attitude towards the diseased middle ear mucosa during intact canal wall tympanoplasty has remained a controversial problem. Our approach consists of the complete removal of the irreversibly diseased mucosal lining. A planned staged operation has been carried out in most cases of tympanoplasty with the use of Silastic sheeting. At the time of the second operation, the middle ear and mastoid process appear to be lined by the regenerated mucosa and pneumatized. 54 mucosal biopsies taken during the second stage of the operation showed a normal flat, cuboidal and pseudostratified ciliated epithelium with functional features (secretory granules, microvilli and cilia). It is concluded that the diseased middle ear mucosa can be removed whenever necessary during staged closed-tympanoplasty operations because under the Silastic sheeting the mucosa will be regenerated within 12 months.
mesh_terms: D001706:Biopsy; D002781:Cholesteatoma / Q000473:pathology; D003238:Connective Tissue / Q000473:pathology; D004432:Ear, Middle / Q000473:pathology / Q000502:physiology*; D004848:Epithelium / Q000473:pathology; D006801:Humans; D009092:Mucous Membrane / Q000473:pathology / Q000502:physiology; D010033:Otitis Media / Q000473:pathology; D012038:Regeneration; D014433:Tympanoplasty; D014945:Wound Healing