Effect of virus antibody on infection of mouse brain by Mount Elgon bat virus.
Intranasal inoculation of mice aged 1-6 days with Mount Elgon but virus produced an acute brain infection and death of all the mice at 5-7 days after inoculation. Virus multiple in the olfactory bulbs and spread to the midbrain and then hindbrain, reaching titres of 10(9)-10(1)) plaque forming units/g of wet tissue. Fatal disease was prevented by administration of virus antibody after infection, which was then restricted to the olfactory bulbs. Antibody was about 99% in olfactory bulbs but by only a small fraction in midbrain and hindbrain. The findings may reflect differences in virus maturation and spread, and the accessibility of virus antibody to the olfactory bulbs, midbrain and hindbrain.
D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000008:administration & dosage / Q000276:immunology*; D001927:Brain Diseases / Q000276:immunology*; D005260:Female; D008636:Mesencephalon; D051379:Mice; D009830:Olfactory Bulb; D013997:Time Factors; D014777:Virus Diseases / Q000276:immunology*; D014779:Virus Replication
D000914:Antibodies, Viral