title: Degeneration activity of the pineal gland after sympathetic denervation.
abstract: After removal of the superior cervical ganglia the pineal gland of the rat showed a period of transient increase in activity of serotonin-N-acetyltransferase. This degeneration activity was preceded by a decline of the levels of endogenous noradrenaline and an impairment of the 3H-metaraminol uptake. Twenty-seven hours after sympathetic denervation the levels of the endogenous neurotransmitter were almost completely depleted, while either 24 h or 21 days after denervation total uptake of the tritiated amine decreased to only about 50% of the control values. Previous chronic sympathetic decentralization elicited in the pineal gland post-junctional supersensitivity, as judged by the enhanced degeneration activity observed in decentralized glands after sympathetic denervation. The present findings confirm that, in endocrine glands and similarly to other autonomically innervated organs, acute denervation induces degeneration activity.
mesh_terms: D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000032:analysis; D005728:Ganglia, Sympathetic / Q000601:surgery; D008297:Male; D008680:Metaraminol / Q000378:metabolism; D009638:Norepinephrine / Q000032:analysis; D010870:Pineal Gland / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013562:Sympathectomy
chemical_list: D008680:Metaraminol; D001191:Arylamine N-Acetyltransferase; D009638:Norepinephrine