Noradrenaline and dopamine contents in rat heart and adrenals in spontaneous, renovascular and stress-induced hypertension.
The noradrenaline and dopamine contents of heart and adrenal gland were estimated in rats with spontaneous, renal and stress-induced hypertension. Systolic blood pressure was also measured before sacrificing the animals. Both the noradrenaline (NA) and dopamine (DA) contents were increased in the adrenals and decreased in the heart. Adrenal gland weight and the ratio of the ventricular weight to body weight of hypertensive rats were significantly higher than those of normal rats. The possibility is that dopamine along with noradrenaline may be playing an important role in peripheral organs, such as adrenal gland and heart, in the pathogenesis of hypertension.
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D004298:Dopamine / Q000378:metabolism*; D006973:Hypertension / Q000378:metabolism* / Q000503:physiopathology; D006977:Hypertension, Renal / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D009929:Organ Size; D051381:Rats
D004298:Dopamine; D009638:Norepinephrine