Some observations and speculations on the factors influencing the concentration of phenylbutazone in synovial fluid.
Simultaneous plasma and synovial fluid samples have been obtained from patients, having reached a steady state on phenylbutazone, as a means of investigating factors influencing drug penetration into synovial fluid. Synovial fluid levels are lower than, but related to, plasma levels and are higher in rheumatoid disease (55-100% plasma levels) than in osteoarthritis (less than 50%). Patients with a more active form of the disease have higher synovial fluid drug concentrations. Results are discussed in the light of present knowledge and areas for further study are proposed.
D000418:Albumins / Q000378:metabolism; D001172:Arthritis, Rheumatoid / Q000378:metabolism; D006801:Humans; D010003:Osteoarthritis / Q000378:metabolism; D010653:Phenylbutazone / Q000097:blood / Q000378:metabolism*; D013582:Synovial Fluid / Q000378:metabolism*
D000418:Albumins; D010653:Phenylbutazone