Effect of coronary blood flow on uptake and washout of Tc-99m DMPE and Tl-201.
After intravenous administration of Tc-99m DMPE the flow-dependent kinetics were studied in dogs during induced ischemia and during induced maximal reactive hyperemia. A control group was also studied. Mean time-activity curves obtained from the myocardial wall were compared within the same intervention group and also with other groups. During reactive hyperemia, there was a rapid and absolute increase in uptake followed by a rapid washout, whereas during ischemia there was a slow and decreased uptake followed by a slow washout. The magnitude of Tc-99m DMPE uptake during reactive hyperemia was slightly less than that of Tl-201, but the decreased uptake with ischemia was about equal for the two agents. Following maximal uptake in the myocardium the effective half-life of Tc-99m DMPE was one-third to one-fourth that of Tl-201. The similar kinetics of Tc-99m DMPE compared to Tl-201 suggests its usefulness in the evaluation of ischemic heart disease.
D000818:Animals; D003326:Coronary Circulation; D003327:Coronary Disease / Q000000981:diagnostic imaging; D004285:Dogs; D006940:Hyperemia / Q000000981:diagnostic imaging; D007700:Kinetics; D009206:Myocardium / Q000378:metabolism*; D015609:Organotechnetium Compounds; D010720:Phosphines / Q000378:metabolism*; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013667:Technetium / Q000378:metabolism*; D013793:Thallium / Q000378:metabolism*
D015609:Organotechnetium Compounds; D010720:Phosphines; D011868:Radioisotopes; D013667:Technetium; C031898:technetium Tc 99m bis(1,2-dimethylphosphino)ethane; D013793:Thallium