Pharmacokinetics and metabolism of [35S]-Thiazolidine carboxylic acid in the rat. I. Elimination and distribution.
The localization and elimination of 35S-Thiazolidine carboxylic acid has been studied in rats following a single oral dose (100 mg/kg) and multiple oral doses (100 mg/kg/day) over 15 days. The compound was rapidly and completely absorbed as evaluated by the time of the maximum plasma 35S-concentration (140 micrograms eq/ml at 30 min) and the amount of radioactivity in the feces (less than 1% of the dose over 48 h). Urinary excretion seems to be the unique route of elimination. There was specific tissue accumulation of drug or metabolite, particularly in liver (29% of the dose at 3 h), pancreas (7% of the dose at 3 h), adrenals (320 micrograms eq/g at 3 h), pituitary and thyroid (230 micrograms eq/g at 3h). Fixation of radioactivity appears significantly higher after chronic treatment than after acute treatment.
D000818:Animals; D005243:Feces / Q000032:analysis; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013462:Sulfur Radioisotopes; D013844:Thiazoles / Q000378:metabolism*; D053778:Thiazolidines; D013997:Time Factors; D014018:Tissue Distribution
D013462:Sulfur Radioisotopes; D013844:Thiazoles; D053778:Thiazolidines; C003438:thiazolidine-4-carboxylic acid