Effect of N,N-dimethyl-p-methoxyphenylethylamine on blood pressure and brain catecholamines in DOCA-saline hypertensive rats.
Intraperitoneal and intraventricular injections of N,N-dimethyl-p-methoxyphenyl ethylamine (PMPEA) decreased blood pressure in conscious DOCA-saline hypertensive rats. Bilateral injection of this agent into the nucleus tractus solitarii (NTS) of anaesthetized normotensive rats also caused a decrease in blood pressure. The increased turnover of noradrenaline in the dorsal part of the caudal medulla oblongata in DOCA-saline hypertensive rats was found to be restored to normal following treatment with N,N-dimethyl PMPEA. The data indicate a central site of action for the antihypertensive effect of N,N-dimethyl PMPEA.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism*; D003900:Desoxycorticosterone; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride; D014439:Tyramine / Q000031:analogs & derivatives* / Q000494:pharmacology
D000959:Antihypertensive Agents; D002395:Catecholamines; D003900:Desoxycorticosterone; D012965:Sodium Chloride; C032141:N,N-dimethyl-4-methoxyphenylethylamine; D014439:Tyramine