Dichloroacetate tissue concentrations and its relationship to hypolactatemia and pyruvate dehydrogenase activation.
Following a single oral dose of DCA to laboratory rats, peak hepatic tissue DCA concentration occurred at 3 hr. When given chronically for 7 days, DCA caused activation of the pyruvate dehydrogenase complex which returned to basal activity 24 hr following the final dose. Hepatic tissue DCA concentrations were maximally increased at 3 hr following the final dose, and the drug was eliminated slowly over 72 hr with a half-life of 9.74 hr. Liver and muscle showed similar DCA tissue concentrations following chronic administration.
D000085:Acetates / Q000378:metabolism*; D000818:Animals; D003999:Dichloroacetic Acid / Q000378:metabolism* / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D007773:Lactates / Q000097:blood*; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000085:Acetates; D007773:Lactates; D011768:Pyruvate Dehydrogenase Complex; D003999:Dichloroacetic Acid