Metastatic retinoblastoma and L-phenylalanine mustard-dianhydrogalactitol.
Retinoblastomas heterotransplanted to nude mice were shown to be sensitive to a combination of phenylalanine mustard and dianhydrogalactitol. A patient with metastatic retinoblastoma was treated with this combination and had a significant response with complete clinical clearance of her bone marrow and metastatic tumors. However, the patient's response was similar to that observed in nude mice; recurrences of tumors developed after complete clinical remission.
D000818:Animals; D002675:Child, Preschool; D003961:Dianhydrogalactitol / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005134:Eye Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008558:Melphalan / Q000008:administration & dosage*; D051379:Mice; D008819:Mice, Nude; D009364:Neoplasm Recurrence, Local; D012175:Retinoblastoma / Q000188:drug therapy* / Q000556:secondary; D013402:Sugar Alcohols / Q000008:administration & dosage*
D013402:Sugar Alcohols; D003961:Dianhydrogalactitol; D008558:Melphalan