HLA antigens in epileptic patients with drug-induced immunodeficiency.
Thirty-two patients with epilepsy were typed for 26 HLA-A, -B and -C antigens. Sixteen of the patients were treated with phenytoin. They all had serum IgA concentrations below 0.20 g/l. Another 16 patients received carbamazepine. This group had showed a marked decrease of IgA and IgM serum concentrations during their first month of carbamazepine monotherapy. Among those who showed an IgA deficiency during phenytoin treatment, 14 had the antigen HLA-A2. The frequency of HLA-A2 was similar between controls and patients who had reduced immunoglobulin levels after 1 month of carbamazepine treatment.
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects; D004406:Dysgammaglobulinemia / Q000139:chemically induced*; D004827:Epilepsy / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006680:HLA Antigens; D006801:Humans; D017098:IgA Deficiency; D007075:Immunoglobulin M / Q000172:deficiency; D008297:Male; D010672:Phenytoin / Q000009:adverse effects
D000927:Anticonvulsants; D006680:HLA Antigens; D007075:Immunoglobulin M; D002220:Carbamazepine; D010672:Phenytoin