Induction of a slowly growing transplantable adenocarcinoma metastasizing into the lungs.
In male Long Evans rats Dibutylnitrosamin induces adenocarcinomas of the lung. Transplantation of a tumor cell suspension prepared from the tumor leads in 100% of cases to death by metastases from adenocarcinoma of the lung after an average of 24 weeks when applied i.m. in a syngeneic system.
D000230:Adenocarcinoma / Q000401:mortality / Q000556:secondary*; D000818:Animals; D005260:Female; D006258:Head and Neck Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary*; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010997:Pleural Neoplasms / Q000556:secondary; D051381:Rats