title: Reduced level of cellular glucocorticoid receptors in patients with anorexia nervosa.
abstract: Specific glucocorticoid receptors were measured in circulating mononuclear leukocytes from 12 patients with anorexia nervosa and 21 healthy control subjects. Cells from patients were found to contain a significantly (p less than 0.01) lower level of glucocorticoid receptor (3830 +/- 210 sites/cell, mean +/- SE) than those from controls (4930 +/- 250 sites/cell). A partial glucocorticoid receptor defect may well explain the abnormal cortisol metabolism and glucocorticoid resistance commonly found in patients with anorexia nervosa.
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000378:metabolism*; D002648:Child; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007962:Leukocytes / Q000032:analysis; D008297:Male; D011965:Receptors, Glucocorticoid / Q000032:analysis*; D011987:Receptors, Steroid / Q000032:analysis*
chemical_list: D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D006854:Hydrocortisone