Effect of oxygen radicals on heart mitochondrial function in alpha-tocopherol deficient rabbits.
The mitochondria extracted from hearts of alpha-tocopherol deficient rabbits showed a decreased mitochondrial function and an increased formation of oxygen radicals associated with a decreased superoxide dismutase activity. The exposure of the alpha-tocopherol deficient mitochondria to exogeneous oxygen radicals caused a marked decrease in the mitochondrial function with respect to control mitochondria, which was partially reversed by the addition in vitro of alpha-tocopherol.
D000818:Animals; D005609:Free Radicals; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects; D011817:Rabbits; D013482:Superoxide Dismutase / Q000378:metabolism*; D014811:Vitamin E Deficiency / Q000378:metabolism*
D005609:Free Radicals; D013482:Superoxide Dismutase; D010100:Oxygen