Pharmacokinetics of resorcinol in the rat.
Pharmacokinetic data on resorcinol were obtained from studies in the rat. The drug, administered subcutaneously in an aqueous solution, rapidly cleared plasma vir urine and did not accumulate in tissues. In the urine, the major metabolite of resorcinol was the glucuronide. Repeated dosing for 30 days with maximum tolerated daily doses of 100 mg/kg did not alter pharmacokinetic parameters, nor did it cause overt toxic signs or adverse reactions. The animals' body weight, blood values, levels of serum T3 and T4' and the gross and microscopic appearance of the thyroid gland and spinal cord remained within normal limits throughout the study.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012118:Resorcinols / Q000378:metabolism* / Q000633:toxicity; D013961:Thyroid Gland / Q000187:drug effects; D014018:Tissue Distribution
D012118:Resorcinols; C031389:resorcinol