Experimental cryptosporidiosis in laboratory mice.
Eight strains of laboratory mice were susceptible to subclinical infections with Cryptosporidium sp. at 1 to 4 days of age, but only a transient infection could be established at 21 days of age or older. Immunosuppression of 21-day-old mice failed to render them more susceptible to infection. Laboratory storage conditions for Cryptosporidium sp. were investigated by titration in 1- to 4-day-old mice. Storage by freezing with a variety of cryoprotectants was unsuccessful, but storage at 4 degrees C in phosphate-buffered saline or 2.5% potassium dichromate was possible for 4 to 6 months.
D000375:Aging; D000818:Animals; D003044:Coccidia / Q000472:pathogenicity; D003048:Coccidiosis / Q000276:immunology / Q000469:parasitology; D003520:Cyclophosphamide / Q000494:pharmacology; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D005615:Freezing; D007165:Immunosuppression Therapy; D007421:Intestine, Small / Q000469:parasitology; D051379:Mice; D008815:Mice, Inbred Strains; D011309:Preservation, Biological
D003520:Cyclophosphamide