title: Naloxone-induced epileptogenesis has brain-site specificity in rats.
abstract: Naloxone injected into the lateral septum caused intense electrocortical seizures which did not occur following callosal or periaqueductal gray (PAG) injections. Conversely, injections into periaqueductal gray caused a characteristic and pronounced backward circling with only moderate electrocortical changes. Intracerebral injection of naloxone had effects, including epileptogenesis, which appeared to be site-specific. These effects are in some ways similar to the effects of enkephalin and morphine.
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D003292:Convulsants / Q000494:pharmacology*; D004569:Electroencephalography; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced*
chemical_list: D003292:Convulsants; D009270:Naloxone