[Isoniazid and rifampicin in the rabbit. Effect on hepatic microsomal enzyme activity].
1. Enzymatic induction or inhibition induced by isoniazid (10 mg/kg) and/or rifampicin (13 mg/kg) oral treatment of 13 days in the rabbit, is evaluated with the following parameters: --variation of antipyrine half-life measured before treatment and 24 h after the end of treatment, --cytochrome P450 content, aniline hydroxylase and aminopyrine N-demethylase activities in hepatic microsomes. Isoniazid half-life is evaluated before treatment, in order to obtain an homogeneous repartition of animals in each group: isoniazid, rifampicin, isoniazid + rifampicin and control. 2. Rifampicin treatment gives a variable enzyme induction of antipyrine metabolism, cytochrome P450 and aniline hydroxylase activity; aminopyrine N-demethylase activity is significantly inhibited. Isoniazid treatment inhibits antipyrine metabolism and increases the cytochrome P450 content.
D000818:Animals; D000983:Antipyrine / Q000378:metabolism; D004347:Drug Interactions; D006207:Half-Life; D007538:Isoniazid / Q000494:pharmacology*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D011817:Rabbits; D012293:Rifampin / Q000494:pharmacology*
D006899:Mixed Function Oxygenases; D000983:Antipyrine; D007538:Isoniazid; D012293:Rifampin
Isoniazide et rifampicine chez le lapin. Influence sur l'activté enzymatique des microsomes hépatiques.