The effect of controlled release copper sulfate and tributyltin fluoride on the mortality and infectivity of Schistosoma mansoni miracidia.
The experiments were conducted to assess the effect of sublethal concentration of controlled release copper sulfate (EC-8) and tribultyltin fluoride (CBL-9B) on the mortality and infectivity of Schistosoma mansoni miracidia. It was found that LC50 and LC90 of EC-8 to the miracidia were 8.5 mg/l per hr and 15.75 mg/l per hr respectively. For CBL-9B, LC50 was 19.75 microgram/l per hr and LC90 was 32.0 microgram/l per hr. Exposing of the miracidia to 0.5 mg/l of EC-8 or 4.0 microgram/l of CBL-9B respectively, for only one hour can prevent their transmission to the snail host. The results indicate that immobilization of the free living stages of the schistosome parasite was not required to interrupt their transmission to the next hosts.
D000818:Animals; D001700:Biomphalaria / Q000187:drug effects; D003300:Copper / Q000633:toxicity*; D019327:Copper Sulfate; D003692:Delayed-Action Preparations; D007928:Lethal Dose 50; D012550:Schistosoma mansoni / Q000187:drug effects* / Q000254:growth & development; D014220:Trialkyltin Compounds / Q000633:toxicity*
D003692:Delayed-Action Preparations; D014220:Trialkyltin Compounds; C011559:tributyltin; D003300:Copper; D019327:Copper Sulfate