The effect of prostaglandins on climbing behavior induced by apomorphine in mice.
Prostaglandins E2, F2 alpha, D2 and I2 administered intracerebroventricularly in a dose of 1 microgram, inhibited the climbing behavior induced by apomorphine. The most active in this respect was PGE2, the least--PGD2. The results indicate the participation of prostaglandins in the regulation of central dopaminergic function.
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D011453:Prostaglandins / Q000494:pharmacology*; D013997:Time Factors
D011453:Prostaglandins; D001058:Apomorphine