title: Digital and sampled-data control of arterial blood pressure during halothane anesthesia.
abstract: A control system that maintains mean arterial pressure (MAP) at a desired level by automatically controlling halothane input has been developed. The control system is a discrete, digital type and is implemented with a small desk-top programmable calculator. Essentially, if MAP decreases, the inspired concentration of halothane will decrease; if MAP increases, the system will compensate by increasing inspired halothane concentration. The control system was tested in two ways: with a hybrid computer model of uptake and distribution of halothane and with dog experiments. The results indicate that (a) the model can be used to predict the response of the animal-anesthesia machine control system, and (b) the proposed algorithm is successful in controlling one anesthetic agent with one physiologic variable.
mesh_terms: D000776:Anesthesiology / Q000295:instrumentation*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination / Q000295:instrumentation*; D003201:Computers; D004285:Dogs; D006221:Halothane / Q000008:administration & dosage* / Q000378:metabolism; D008954:Models, Biological; D008991:Monitoring, Physiologic / Q000295:instrumentation
chemical_list: D006221:Halothane