title: Non-ossifying fibroma or benign lipoblastoma of bone--an electron-microscopic and histochemical study.
abstract: An ultrastructural and histochemical analysis was made of a lesion identified by light microscopy as a non-ossifying fibroma of bone. A histogenetic sequence was traced from spindle-shaped fibroblast-like cells to multivacuolated lipoblasts with abundant glycogen. These lipid-laden cells showed remarkable similarity to some cells of a well differentiated liposarcoma. Others have interpreted the lipid-containing cells of non-ossifying fibroma as representing fibroblasts which have imbibed or synthesized lipid or lipid-laden macrophages. Our studies demonstrate that this tumour consists of primitive mesenchymal cells with partial maturation to early lipoblasts, suggesting its classification as a benign lipoblastoma of bone.
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D005260:Female; D005350:Fibroma / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D006801:Humans; D008067:Lipoma / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D008080:Liposarcoma / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure