[Modification of extrapyramidal signs by apomorphine associated with various dopaminergic antagonists].
An acute administration of various doses of apomorphine, a dopaminergic agonist, and of dopaminergic receptor blockers (domperidone, sulpiride, haloperidol), was double-blindly achieved in a parkinsonian patient also suffering from dyskinesia. Apomorphine improved tremor and dyskinesia proportionnally to the dose. Domperidone did not prevent from this beneficial effect whereas sulpiride or haloperidol revealed a competitive antagonism versus apomorphine.
D000368:Aged; D001058:Apomorphine / Q000627:therapeutic use*; D001480:Basal Ganglia Diseases / Q000188:drug therapy*; D018492:Dopamine Antagonists; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D009069:Movement Disorders / Q000188:drug therapy*; D011954:Receptors, Dopamine / Q000187:drug effects*
D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D001058:Apomorphine
Modifications de signes extra-pyramidaux par l'apomorphine associée à différents antagonistes dopaminergiques.