title: [Pharmacokinetics of dibekacin in subjects with normal renal function].
abstract: The principal pharmacokinetic parameters of dibekacin were studied in five adult subjects with normal renal function after IM and IV injection of a single dose of 1 mg/kg. The results obtained showed that the pharmacokinetics of dibekacine were independent of the dose (T1/2: 2.1 h; distribution volume: 14-161; renal clearance: congruent to 70 ml/min; urinary excretion in 24 hours congruent to 80%) and very similar to those of other aminoglycosides of the deoxystreptamine group.
mesh_terms: D000328:Adult; D003982:Dibekacin / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007612:Kanamycin / Q000031:analogs & derivatives*; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008297:Male
chemical_list: D003982:Dibekacin; D007612:Kanamycin
vernacular_title: Pharmacocinétique de la dibékacine chez le sujet à fonction rénale normale.