title: Prostatic glutathione S-transferase in rat, guinea pig and rabbit.
abstract: The occurrence of soluble glutathione S-transferase (GST) in the prostate of rat, guinea pig and rabbit is reported. With 1-chloro-2,4-dinitrobenzene (CDNB) as the second substrate a specific activity of 59 nmol product/min/mg protein was found in the rat. A value of approx. 2 x and 25 x higher was found for guinea-pig and rabbit respectively. GST activity was also demonstrated with 3 other substrates. GST C was the most abundant CDNB-GST isoenzyme (76%) in rat prostate, followed by GST A (17%) and GST AA (7%), significant amounts of other isoenzymes not being found. The presence of GST in the prostate suggests that these enzymes may play a role in the metabolism and detoxification of electrophilic xenobiotics.
mesh_terms: D000818:Animals; D005982:Glutathione Transferase / Q000378:metabolism*; D006168:Guinea Pigs; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D011467:Prostate / Q000201:enzymology*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013379:Substrate Specificity
chemical_list: D007527:Isoenzymes; D005982:Glutathione Transferase