title: Genotoxicity induced in cultured Chinese hamster cells exposed to natural or synthetic crude oils and near ultraviolet light.
abstract: Cultured Chinese hamster ovary (CHO) cells were incubated with dilutions of natural or synthetic crude oils and subsequently exposed to near ultraviolet light (NUV). Although the magnitude of photo-induced cytotoxicity in CHO was essentially independent of the source of the oil (within a factor of two), two shale oils were exceptionally high in photo-induced mutagenic activity eliciting a response 10-12 times the observed natural background mutation frequency. Other shale oils, natural crude oils and a solvent refined coal medium distillate blend were weaker or negative in photo-induced mutagenic activity. Hydrotreatment of a photoactive shale oil, although eliminating the mutagenic potential, did not reduce the oil's cytotoxic potential.
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects* / Q000528:radiation effects; D002460:Cell Line; D003114:Colony-Forming Units Assay; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D009154:Mutation / Q000187:drug effects* / Q000528:radiation effects; D010053:Ovary; D010578:Petroleum / Q000633:toxicity*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D010578:Petroleum