Newer phenothiazines as anticonvulsants and monoamine oxidase inhibitors.
Eight new compounds have been synthesised in the series of 10-(alpha-aminoacylhydrazinoacetyl)phenothiazines. Their structures have been confirmed by elemental analysis and IR spectroscopic studies. The compounds have been found to possess the protection of mice against chemoshock- and electroshock-induced seizures and the monoamineoxidase (MAO) inhibitory activity. A good correlation between these two activities and the structure of the compounds has been found.
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis*; D010640:Phenothiazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000927:Anticonvulsants; D008996:Monoamine Oxidase Inhibitors; D010640:Phenothiazines