title: Chloride removal selectively inhibits phasic contractions of guinea pig ileal longitudinal smooth muscle.
abstract: Removal of external chloride selectively and reversibly inhibits the phasic responses of the guinea pig ileal longitudinal muscle to high potassium and cholinergic stimulation. The binding of calcium to a relatively superficial pool is affected by chloride removal. Alterations in anionic composition of bathing solution affects the availability of calcium for excitation--contraction (E--C) coupling in smooth muscle.
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002712:Chlorides / Q000502:physiology*; D006168:Guinea Pigs; D007082:Ileum / Q000502:physiology; D066298:In Vitro Techniques; D008623:Mercaptoethanol / Q000031:analogs & derivatives / Q000494:pharmacology; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000502:physiology*; D010277:Parasympathomimetics / Q000494:pharmacology
chemical_list: D002712:Chlorides; D010277:Parasympathomimetics; D008623:Mercaptoethanol; C018325:isethinic acid; D002118:Calcium