[Effect of contactin from the lung on the cellular proliferative activity of the alveolar wall].
The influence of contactine from rat lung on DNA synthesis in pulmonary alveolar tissue of A mice was studied in vivo. Two-fold decrease in the total index of pulmonary tissue cells labeled with 3H-thymidine was observed 7-24 hours following the contactine injection. The inhibition of DNA syntheses was observed at the same concentrations at which a cell cohesion increases. The results presented indicate that the effect of contactine on proliferative activity in vivo may be realized through its influence on cell cohesion.
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D008168:Lung; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D011650:Pulmonary Alveoli / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000494:pharmacology; D013997:Time Factors; D014020:Tissue Extracts / Q000494:pharmacology*; D014520:Urethane / Q000494:pharmacology
D012709:Serum Albumin; D014020:Tissue Extracts; D014520:Urethane
Vliianie kontaktina iz legkogo na proliferativnuiu aktivnost' kletok stenki al'veoly.