Antitumor effect of palmitoleic acid on Ehrlich ascites tumor.
Palmitoleic acid (PLOA) markedly prolonged the survival time of mice bearing Ehrlich ascites tumor at doses of 37.5-150 mg/kg/day X 10, but the antitumor activity of oleic acid (OA) was weaker than that of PLOA. The total lipid and phospholipid contents in the tumor cells treated with PLOA were significantly decreased. In addition, the fatty acid pattern of phosphatidyl choline, cholesterol esters and triglycerides from the PLOA-treated Ehrlich tumor cells differed markedly from that of the corresponding lipids from the control tumor cells.
D000818:Animals; D000970:Antineoplastic Agents; D002286:Carcinoma, Ehrlich Tumor / Q000032:analysis / Q000188:drug therapy*; D005229:Fatty Acids, Monounsaturated; D005260:Female; D008055:Lipids / Q000032:analysis; D051379:Mice; D008813:Mice, Inbred ICR; D019301:Oleic Acid; D009829:Oleic Acids / Q000627:therapeutic use; D010169:Palmitic Acids / Q000627:therapeutic use*; D010743:Phospholipids / Q000032:analysis; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D005229:Fatty Acids, Monounsaturated; D008055:Lipids; D009829:Oleic Acids; D010169:Palmitic Acids; D010743:Phospholipids; C008757:palmitoleic acid; D019301:Oleic Acid