Physiological and behavioral correlates of lifespan in aged C57BL/6J mice.
Physiological and behavioral measurements were made in a cohort of 29-month-old male C57BL/6J mice to determine whether any correlated significantly with lifespan. Significant linear relationships with lifespan were found among the physiological measures, including hematocrit and hemoglobin levels and collagen denaturation rate; however, body weight failed to be a significant predictor of survival. Among the behavioral variables studied, significant quadratic relationships with lifespan were found for exploratory activity and passive avoidance learning, while performance on a rotorod and a tightwire showed no significant relationships with lifespan. Through the use of multiple regression techniques, about one-third of the variance in lifespan could be explained by a combination of physiological variables, and about two-fifths could be explained by a combination of behavioral variables.
D000375:Aging; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology*; D003094:Collagen / Q000378:metabolism; D005106:Exploratory Behavior; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D008136:Longevity; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000502:physiology*; D011489:Protein Denaturation; D012044:Regression Analysis
D006454:Hemoglobins; D003094:Collagen