[Characteristics of the action of different doses of panangin and isoptin on the collateral blood supply to the heart in coronarogenic myocardial lesion].
The effects of isoptin and panangin on the collateral coronary blood flow have been examined in dogs during acute occlusion of the left coronary artery. It has been established that panangin (1 and 6 mg/kg) and isoptin (0.005 mg/kg) increase the collateral blood inflow to the ischemic zone, raise the cardiac output, and reduce the peripheral resistance. The raising of the isoptin dose up to 0.01 mg/kg inhibits the blood supply of the affected area, decreases the systolic and minute heart volumes.
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives*; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D003097:Collateral Circulation / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D011195:Potassium Magnesium Aspartate / Q000008:administration & dosage*; D014700:Verapamil / Q000008:administration & dosage*
D002121:Calcium Channel Blockers; D001224:Aspartic Acid; D011195:Potassium Magnesium Aspartate; D014700:Verapamil
Osobennosti deĭstviia razlichnykh doz panagina i izoptina na kollateral'noe krovosnabzhenie serdtsa pri koronarogennom porazhenii miokarda.