Partial ileal bypass in treatment of familial hypercholesterolaemia.
The effects of partial ileal bypass have been studied in 7 patients with heterozygous familial hypercholesterolaemia. By the seventh to ninth postoperative day there was a significant fall in plasma cholesterol of 42.8% compared with levels at initial presentation. Thereafter, plasma levels of cholesterol rose by varying degrees, but had stabilized by 3 months with average values 29.5% lower than pretreatment. Debilitating diarrhoea or severe weight loss were not troublesome features of the operation in most patients.
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000628:therapy*; D007082:Ileum / Q000601:surgery*; D008297:Male; D008722:Methods; D008875:Middle Aged; D011183:Postoperative Complications