[Corticosteroid mechanism as a leading element of the thymotropic effect of oxythiamine in the rat].
Oxythiamine B1-hypovitaminosis in adrenalectomized male rats is not accompanied by acute thymus involution. This is not so much related to hypocorticoidism per se, as to a decrease in metabolic potencies of the antivitamin, particularly to a negligible depression of thymocyte tolerance to hydrocortisone. Sex differences in morphological parameters of thymus lymphopoiesis have been found after adrenalectomy.
D000315:Adrenalectomy; D000818:Animals; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology / Q000502:physiology*; D008297:Male; D010119:Oxythiamine / Q000494:pharmacology*; D051381:Rats; D013832:Thiamine Deficiency / Q000473:pathology / Q000503:physiopathology*; D013844:Thiazoles / Q000494:pharmacology*; D013950:Thymus Gland / Q000187:drug effects* / Q000473:pathology
D013844:Thiazoles; D010119:Oxythiamine; D006854:Hydrocortisone
Kortikosteroidnyĭ mekhanizm--vedushchee zveno timotropnogo éffekta oksitiamina u krys.