title: Development of a protocol for photoradiation therapy of malignant brain tumors: part 1. Photosensitization of normal brain tissue with hematoporphyrin derivative.
abstract: The successful application of phototherapy to subcutaneous tumors has suggested that a similar procedure should be developed for treating gliomas. As a result, attempts are being made to determine a set of conditions that would optimize the destruction of tumor cells while minimizing injury to surrounding brain tissue. To initiate this task, we developed a novel assay method to assess the amount of phototoxicity induced in normal brain by light exposure of mice treated with hematoporphyrin derivative (HPD). The application of this procedure demonstrated that a sufficient amount of HPD was retained in brain tissue, even 72 hours after injection, to cause severe cerebral damage in light-treated mice.
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects*; D001932:Brain Neoplasms / Q000188:drug therapy; D005910:Glioma / Q000188:drug therapy; D006415:Hematoporphyrins / Q000009:adverse effects*; D008297:Male; D051379:Mice; D010789:Phototherapy; D013752:Tetracycline
chemical_list: D006415:Hematoporphyrins; D013752:Tetracycline