Effect of 5-thio-D-glucose on testicular lipids of mice.
Spermatogenesis is reported to be completely inhibited by 5-thio-D-glucose in mice. In an investigation of this inhibition, testicular lipid constituents, namely, total lipids, phospholipids, triacylglycerol, free and total cholesterol, 3-hydroxy-3-methylglutaryl-coenzyme A reductase and NADPH generators like glucose-6-phosphate dehydrogenase, isocitrate dehyrogenase and malic enzyme were estimated in mice fed with 5-thio-D-glucose (33 mg/kg) by gastric intubation for 21 days. Significant increase in cholesteryl ester, glucose-6-phosphate dehydrogenase activity and malic enzyme and a decrease in free cholesterol and phospholipids were observed.
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D005947:Glucose / Q000031:analogs & derivatives* / Q000494:pharmacology; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D050356:Lipid Metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D051379:Mice; D010743:Phospholipids / Q000378:metabolism; D013737:Testis / Q000187:drug effects / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism
D010743:Phospholipids; D014280:Triglycerides; C003002:5-thio-D-glucose; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D005947:Glucose