Prophylactic netilmicin in surgery.
Seventy-seven elective or emergency surgical patients were treated with a prophylactic course of netilmicin. Netilmicin (150 mg intramuscularly) was given 1 hour prior to operation and continued 12 hourly until the patient was free of risk of post-operative infection. There was no microbiological or clinical evidence of post-operative infection in general surgical or orthopaedic patients. Netilmicin seems to be less nephrotoxic than other aminoglycosides. Netilmicin serum levels were within expected values. Netilmicin was found to be an effective and well-tolerated antibiotic, and prophylactic treatment shortened the mean patient bed-stay and hence costs incurred.
D000328:Adult; D000368:Aged; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D007668:Kidney / Q000187:drug effects; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D008875:Middle Aged; D009428:Netilmicin / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control*; D014946:Wound Infection / Q000517:prevention & control*
D005839:Gentamicins; D009428:Netilmicin