Vitamin status in patients on chronic anticonvulsant therapy.
Vitamin levels in blood were estimated in 146 epileptics, aged 20-40 years. Compared to healthy subjects, no higher risk rates of a vitamin deficiency were found in epileptics for vitamins B1, B12, A, C, E and beta-carotene. alpha EGR was elevated only in epileptic females, alpha EGOT in epileptic males, indicating a higher risk of a vitamin B2 and B6 deficiency in these groups. Markedly reduced levels of folate, 25-hydroxy-cholecalciferol, and biotin were found in the epileptics; folate and biotin levels showed a significant negative correlation with the total amount and the average daily dose of anticonvulsants administered.
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D001710:Biotin / Q000172:deficiency; D002112:Calcifediol / Q000172:deficiency; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005494:Folic Acid Deficiency / Q000139:chemically induced; D006801:Humans; D008297:Male; D012257:Riboflavin Deficiency / Q000139:chemically induced; D012737:Sex Factors; D026681:Vitamin B 6 Deficiency / Q000139:chemically induced; D014815:Vitamins / Q000097:blood*
D000927:Anticonvulsants; D014815:Vitamins; D001710:Biotin; D002112:Calcifediol