Effect of chronic phencyclidine or d-amphetamine treatment on [3H]spiroperidol binding in rat caudate-putamen and nucleus accumbens.
Chronic treatment (20 days) of rats with d-amphetamine decreased the density, but had no effect on the apparent affinity of [3H]spiroperidol binding sites in caudate-putamen and nucleus accumbens. In contrast, chronic phencyclidine treatment had no effect either on the number or on the affinity of [3H]spiroperidol binding sites in these two brain regions.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002090:Butyrophenones / Q000378:metabolism*; D002421:Caudate Nucleus / Q000378:metabolism; D003913:Dextroamphetamine / Q000494:pharmacology*; D008297:Male; D009714:Nucleus Accumbens / Q000378:metabolism; D010622:Phencyclidine / Q000494:pharmacology*; D011699:Putamen / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013134:Spiperone / Q000378:metabolism*; D014316:Tritium
D002090:Butyrophenones; D014316:Tritium; D013134:Spiperone; D010622:Phencyclidine; D003913:Dextroamphetamine