Cholestyramine plus pectin in treatment of patients with familial hypercholesterolemia.
The effects of a combined therapy, composed of a cholesterol-lowering diet, cholestyramine (16 g/day) and apple pectin (12 g/day), were studied on serum lipoproteins in 6 men with familial hypercholesterolemia. All subjects were treated with diet alone, diet plus cholestyramine and diet plus cholestyramine and pectin for at least 8 weeks on each regimen. In these severely hypercholesterolemic subjects the combined treatment with diet plus cholestyramine and pectin lowered serum cholesterol by 31% and LDL-cholesterol by 35% corresponding to a 19% and 22% further decrease respectively relative to diet plus cholestyramine. We conclude that the addition of the well-tolerated natural cholesterol-lowering product is valuable in the treatment of familial hypercholesterolemia.
D000328:Adult; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D002792:Cholestyramine Resin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000178:diet therapy / Q000188:drug therapy*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D010368:Pectins / Q000627:therapeutic use*
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D002792:Cholestyramine Resin; D010368:Pectins; D002784:Cholesterol