[Hyperthyroidism and the transmembrane potential of rat liver mitochondria].
Transmembrane potential of liver mitochondria in hyperthyroid rats was higher than that in euthyroid animals. Besides, a lower resistance to Ca2+ of the system responsible for the maintenance of the transmembrane potential was observed in the preparations from hyperthyroid rats. This was manifested in a decrease of the calcium dose required for the decay of the transmembrane potential and in a shorter period of Ca2+ retention by mitochondria. The observed decrease in the resistance to Ca2+ ions of the potential-maintaining system in hyperthyroid mitochondria is supposed to be determined by the increased activity of mitochondrial endogenous phospholipase.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002413:Cations, Divalent / Q000494:pharmacology; D005453:Fluorescence; D006980:Hyperthyroidism / Q000503:physiopathology*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D002413:Cations, Divalent; D002118:Calcium
Gipertireoz i transmembrannyĭ potentsial mitokhondriĭ pecheni krys.