Cardiopulmonary effects of intravenous xylazine, ketamine, and atropine in the dog.
Atropine (0.04 mg/kg of body weight) and the combination of xylazine (1.1 mg/kg) and ketamine (11 mg/kg) were administered IV to dogs, and cardiopulmonary variables were measured. The drug combination caused hypoventilation, as reflected by increased PaCO2 and a 30% decrease in cardiac index, whereas arterial pressure, left atrial pressure, and peripheral resistance were increased. These variables began returning toward base-line values during anesthesia and were not different from base-line values by 30 minutes.
D000758:Anesthesia / Q000662:veterinary*; D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology*; D001784:Blood Gas Analysis / Q000662:veterinary; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs / Q000097:blood / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous / Q000662:veterinary; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology*; D013843:Thiazines / Q000494:pharmacology*; D014991:Xylazine / Q000008:administration & dosage / Q000494:pharmacology*
D013843:Thiazines; D014991:Xylazine; D007649:Ketamine; D001285:Atropine