title: Accessory function of aging Kupffer cells with different lymphocyte populations.
abstract: The present studies show that rat Kupffer cells are capable of both suppression and enhancement of mitogen responses. Studies were conducted using the T-cell mitogens concanavalin A and phytohemmaglutinin, as well as the rat B-cell mitogen Mycoplasma neurolyticum. Whereas Kupffer cell concentrations of 1 X 10(5)/well significantly suppressed the T- and B-mitogen response of both spleen nonadherent and peripheral blood lymphocytes, enhancement was restricted to the T-cell mitogen responses. No tissue-related differences were found in the suppression. However, both tissue differences and age-related changes were observed with enhancement. Age-related changes in the Kupffer cell resulted in a decreased enhancement of the proliferative response of spleen to concanavalin A and an increased response of peripheral blood lymphocytes.
mesh_terms: D000818:Animals; D002469:Cell Separation; D002470:Cell Survival; D003208:Concanavalin A / Q000494:pharmacology; D007108:Immune Tolerance; D007728:Kupffer Cells / Q000276:immunology* / Q000502:physiology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000145:classification / Q000276:immunology*; D008297:Male; D009174:Mycoplasma / Q000276:immunology; D010835:Phytohemagglutinins / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D010835:Phytohemagglutinins; D003208:Concanavalin A