Effect of antioxidants and antitoxicants of isoniazid on the formation of lung tumours in mice by isoniazid and hydrazine sulphate.
The present study reports the effects of antioxidants and antitoxicants on the formation of lung tumours in Swiss mice induced by isoniazid (INH) and hydrazine sulphate (HS). Dietary administration of butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) or simultaneous oral administration of antitoxicants (L-arginine, L-sodium glutamate and pyridoxine hydrochloride) failed to prevent HS-induced lung tumours. On the other hand BHA and BHT inhibited the formation of lung tumours in groups of mice receiving INH. Folic acid supplementation had marginal effect on the formation of lung tumours in groups receiving HS (P less than 0.1). Higher lung tumour incidence was observed in groups maintained only on BHT diet as compared to animals maintained on standard diet.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001120:Arginine / Q000494:pharmacology; D002083:Butylated Hydroxyanisole / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D005492:Folic Acid / Q000494:pharmacology; D006834:Hydrazines / Q000633:toxicity*; D007538:Isoniazid / Q000633:toxicity*; D008175:Lung Neoplasms / Q000139:chemically induced*; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D011736:Pyridoxine / Q000494:pharmacology; D012970:Sodium Glutamate / Q000494:pharmacology
D000975:Antioxidants; D006834:Hydrazines; D002084:Butylated Hydroxytoluene; D002083:Butylated Hydroxyanisole; C029424:hydrazine; D005492:Folic Acid; D001120:Arginine; D011736:Pyridoxine; D007538:Isoniazid; D012970:Sodium Glutamate