Metabolic oxidation of methaqualone in extensive and poor metabolisers of debrisoquine.
The metabolism of methaqualone to the glucuronides of 5 C-monohydroxy metabolites and to the N-oxide has been studied in 2 groups of healthy young adults phenotyped as extensive and poor metabolisers of debrisoquine. No significant interphenotype differences were observed with respect to the excretion of any of the 6 metabolites. It is probable that the genetic regulation of the pathways leading to these metabolites is at a locus other than that which is responsible for the regulation of the oxidation of debrisoquine, guanoxan, phenacetin, phenytoin and sparteine.
D000328:Adult; D001711:Biotransformation; D003647:Debrisoquin / Q000378:metabolism*; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000378:metabolism*; D008297:Male; D008702:Methaqualone / Q000378:metabolism*; D010084:Oxidation-Reduction; D010641:Phenotype
D007546:Isoquinolines; D008702:Methaqualone; D003647:Debrisoquin