title: [Role of cholinergic mechanisms in the action of sodium oxybutyrate on the structures of the hippocampus-reticular complex and of the neocortex].
abstract: It has been established in chronic experiments on rabbits that accumulation of endogenous acetylcholine (galanthamine--1 mg/kg) prevents the development of sodium hydroxybutyrate (500 mg/kg) ability to increase the excitability of the mesencephalic reticular formation and to reduce the level of frontal cortex excitability. Inhibition of the central muscarinic (metamizyl--2 mg/kg) or nicotinic (eterofen--10 mg/kg) cholinoreceptors prevents the stimulant action or sodium hydroxybutyrate on the excitability of the dorsal hippocamp and mesencephalic reticular formation. Blockade of the central N-cholinoreceptors changes the marked effect of sodium hydroxybutyrate on the blood content of the test brain structures. This may attest to the participation of N-cholinoreceptors in the effects of sodium hydroxybutyrate.
mesh_terms: D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D004558:Electric Stimulation; D005625:Frontal Lobe / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects*; D006885:Hydroxybutyrates / Q000494:pharmacology*; D011817:Rabbits; D011950:Receptors, Cholinergic / Q000187:drug effects*; D012154:Reticular Formation / Q000187:drug effects*; D012978:Sodium Oxybate / Q000494:pharmacology*
chemical_list: D006885:Hydroxybutyrates; D011950:Receptors, Cholinergic; D012978:Sodium Oxybate; D000109:Acetylcholine
vernacular_title: Rol'kholinergicheskikh mekhanizmov v deĭstvii natriia oksibutirata na struktury gippokamp-retikuliarnogo kompleksa i novoĭ kory mozga.