title: [Activating effect of cyclophosphane at late stages of persistence of the tick-borne encephalitis virus].
abstract: Conditions of activation of persistent infection caused by subcutaneous inoculation of Syrian hamsters with the B-383 and Vasilchenko strains of tick-borne encephalitis virus (TBE) were studied. After 2 administrations of cyclophosphane (CP) on day 170 of infection clinically manifest disease developed in some animals with increasingly severe pathomorphological lesions in the CNS. Several variants of activated TBE virus were isolated from brains and spleens of CP-treated hamsters. The activation of persistent infection was observed in the presence of marked decreased of humoral immunity level, weight of the thymus, and values of spontaneous rosette-formation.
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D006224:Cricetinae; D003520:Cyclophosphamide / Q000494:pharmacology*; D004669:Encephalitis Viruses, Tick-Borne / Q000254:growth & development*; D004675:Encephalitis, Tick-Borne / Q000276:immunology; D008647:Mesocricetus; D009929:Organ Size; D012397:Rosette Formation; D013950:Thymus Gland / Q000187:drug effects; D014775:Virus Activation / Q000187:drug effects*
chemical_list: D000956:Antigens, Viral; D003520:Cyclophosphamide
vernacular_title: Aktiviruiushchiĭ éffekt tsiklofosfana na pozdnikh étapakh persistentsii virusa kleshchevogo éntsefalita.