Increased blood-brain barrier dysfunction around cerebral stab wounds in rats immunized to brain antigens. A quantitative study on endogenous albumin and globulin.
The extravasation of serum albumin and immunoglobulin G (IgG) was assayed by electroimmunoassay in cerebral cortex homogenates of rats subjected to stab wound injury either 2 weeks after immunisation to brain antigens or without prior immunisation. The amount of IgG in the brain was significantly higher in immunised than in non-immunised rats 3 and 24 h after injury. A significantly enhanced extravasation of albumin in immunised rats was found only after 24 h. It is concluded that immunisation to brain antigens enhances the vulnerability of the blood-brain barrier in rats subjected to stab wound injury.
D000818:Animals; D000941:Antigens / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D001812:Blood-Brain Barrier; D001921:Brain / Q000276:immunology*; D001930:Brain Injuries / Q000276:immunology*; D005625:Frontal Lobe / Q000276:immunology / Q000293:injuries; D007074:Immunoglobulin G / Q000378:metabolism; D008297:Male; D008856:Microscopy, Fluorescence; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000378:metabolism; D014951:Wounds, Stab / Q000276:immunology*
D000941:Antigens; D001324:Autoantigens; D007074:Immunoglobulin G; D012709:Serum Albumin