Glucocorticoid action on protein synthesis and protein breakdown in isolated skeletal muscles.
The direct actions of glucocorticoid hormones on protein turnover were studied in isolated soleus muscles. These steroids were found to decrease the rates of both protein synthesis and protein breakdown within 3 h and 4 h respectively. Synthetic steroids (e.g. dexamethasone) were found to be more potent than naturally secreted hormones (e.g. cortisol) in inducing these changes, but only at concentrations in vitro less than 10nm.
D000818:Animals; D003345:Corticosterone / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006854:Hydrocortisone / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009124:Muscle Proteins / Q000378:metabolism*; D009132:Muscles / Q000187:drug effects; D051381:Rats; D013997:Time Factors; D014222:Triamcinolone Acetonide / Q000494:pharmacology
D009124:Muscle Proteins; D003907:Dexamethasone; D014222:Triamcinolone Acetonide; D003345:Corticosterone; D006854:Hydrocortisone