[Induction of DNA reparative synthesis and the toxic effects of carcinogens in embryonic cell cultures].
The carcinogens used in this work were divided into two groups according to their ability to induce DNA repair synthesis in embryonic cell cultures: powerful inducers (UV-light; N-methyl-N'-nitro-N-nitrosoguanidine; 4-nitroquinoline-1-oxide) and weak inducers (aflatoxin B1; 7,12-dimethylbenz(a)anthracene). In contrast to the latter, the former were found to be strong inhibitors of DNA replicative synthesis. To induce the active DNA repair synthesis, it is necessary to use toxic concentrations of the carcinogens examined.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis* / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects* / Q000528:radiation effects; D005347:Fibroblasts / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D009152:Mutagenicity Tests; D014466:Ultraviolet Rays
D002273:Carcinogens; D004247:DNA
Induktsiia reparativnogo sinteza DNK i toksicheskie éffekty kantserogenov v kul'turakh émbrional'nykh kletok.