[Dynamic action of nebulizers and the influence of breathing technic on the deposition of aerosolized drugs].
Ultrasonic Nebulizers show a variation of aerosol density during the breathing cycle that affects deposition. First there is a relatively dense fraction of aerosol that penetrates deeply into the lung, while the subsequently delivered aerosol reaches only the upper parts of the airways. Calculations show that the effect has a pronounced influence on deposition. The percentage of medicament deposited in the lower airways is significantly increased, although the total amount of medicament is lower than with an aerosol of uniform density.
D000336:Aerosols; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D010316:Particle Size; D012119:Respiration; D012138:Respiratory Therapy / Q000295:instrumentation*; D014464:Ultrasonic Therapy / Q000295:instrumentation
D000336:Aerosols; D001993:Bronchodilator Agents
Dynamisches Verhalten von Verneblern und der Einfluss der Atemtechnik auf die Deposition medizinischer Aerosole.