Effects of intraduodenal feeding of a branched-chain amino acid-rich solution on ammonia-induced encephalopathy in liver-injured rats.
A preventive effect of intraduodenal prefeeding of a branched-chain amino acid (BCAA)-rich solution on ammonia-induced encephalopathy was investigated with carbon tetrachloride CC14-injured rats with the elevated levels of blood ammonia. Five out of six cirrhotic rats, to which an electrolyte solution alone was preinfused for 24 hours, fell into coma following ammonia acetate injection and two comatose rats died. However, no cirrhotic rats preinfused with a BCAA-rich solution died and only two out of the six showed coma with complete recovery. The similar preventive effect could not be observed in rats with acute liver injury.
D000085:Acetates / Q000009:adverse effects; D000208:Acute Disease; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced* / Q000150:complications; D002252:Carbon Tetrachloride Poisoning / Q000150:complications; D004386:Duodenum; D006501:Hepatic Encephalopathy / Q000517:prevention & control*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced* / Q000150:complications; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000085:Acetates; D000597:Amino Acids, Branched-Chain; C018824:ammonium acetate