Piretanide (HOE 118) in dogs.
Piretanide, a "loop" diuretic, was administered orally and IV at 3 dose levels to healthy Beagles. The effects were measured over an 8-hour period. A marked diuresis occurred with both methods of administration at all dose levels. It was characterized by increased excretion of Na+, Cl-, and, to a lesser extent, K+. Urine osmolality and specific gravity decreased significantly, while urine Na+ and K+ concentrations decreased concurrently. Changes from base lines were not detected in hematologic values, except for serum K+ which reached below base line with larger doses. Piretanide is a potent diuretic and treated patients should be monitored for hypokalemia.
D000284:Administration, Oral; D000818:Animals; D002712:Chlorides / Q000097:blood; D004231:Diuresis; D004232:Diuretics / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D008297:Male; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D013449:Sulfonamides / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D002712:Chlorides; D004232:Diuretics; D013449:Sulfonamides; D012964:Sodium; C015451:piretanide; D011188:Potassium