title: Fulminating pneumococcal septicaemia and meningitis in an adult twenty years after splenectomy for a ruptured spleen.
abstract: A nearly fatal course of pneumococcal septicaemia and meningitis in a previously healthy adult, 20 years after splenectomy for a ruptured spleen, is described. This underlines the important role of the spleen in the defence mechanism of the body against pathogenic micro-organisms. Awareness of the existence of this syndrome of overwhelming post-splenectomy infection (OPSI) is clinically important. Several aspects of prevention and treatment are discussed in a review of the literature.
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D008586:Meningitis, Pneumococcal / Q000209:etiology*; D009336:Necrosis / Q000209:etiology; D018805:Sepsis / Q000209:etiology*; D013156:Splenectomy / Q000009:adverse effects*; D013161:Splenic Rupture / Q000601:surgery