Increased noise trauma in guinea pigs through magnesium deficiency.
Mg-deficient guinea pigs developed significantly increased hearing loss during 4 weeks of noise exposure [95 dB(A)] as compared to animals fed a Mg-rich diet. The hearing loss was negatively correlated to the Mg content of the perilymph (r = -0.86). Besides this auditory effect, there was a decrease of intracellular Mg and an increase of collagen in the myocardium, both of which were correlated to the hearing loss and caused by Mg deficiency and noise stress.
D000818:Animals; D001309:Auditory Threshold; D004781:Environmental Exposure; D006168:Guinea Pigs; D006317:Hearing Loss, Noise-Induced / Q000209:etiology* / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D008274:Magnesium / Q000097:blood / Q000378:metabolism; D008275:Magnesium Deficiency / Q000150:complications* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010498:Perilymph / Q000378:metabolism
D008274:Magnesium; D006909:Hydroxyproline