Diagnostic application of nuclear DNA measurements on bronchial secretions.
Bronchial washings from 254 patients with suspected pulmonary malignancy were investigated independently by two methods: bronchial cytologic examination and DNA measurements. For the latter, aneuploidy was used as a criterion of malignancy. At the time of the clinical follow-up, pulmonary malignancy had been verified by histopathologic examination in 91 of these 254 patients. For bronchial cytology the sensitivity was 40% and the specificity was 98%; for the DNA measurements the sensitivity was 37% and the specificity was 99%. Used in combination, the two methods showed a sensitivity of 46% and a specificity of 98%.
D000328:Adult; D000368:Aged; D000782:Aneuploidy; D001980:Bronchi / Q000378:metabolism*; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000032:analysis / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013050:Spectrometry, Fluorescence
D004273:DNA, Neoplasm