[Study of Urinary excretion of total, free, and non-dialysable conjugated hydroxyproline in paraplegics].
Eighteen paraplegics with or without neurogenic osteo-arthropathy (POAN) were evaluated for variations in their urinary excretion levels of total (T), and free (L) hydroxyproline and its non-dialysable (ND) and dialysable (D) peptide fractions. Increases in urinary hydroxyproline, moderate rises in free hydroxyproline and more substantial increases in dialysable and non-dialysable peptide fractions could be observed in these patients who all were affected with osteoporosis of disuse. Only variations in dialysable hydroxyproline could be used to differentiate between POAN + and POAN - patients. Of the various ratios which were analyzed (ND/T, L/ND, and D/ND), the D/ND ratio appears to be the most useful for diagnosis and monitoring of patients with POAN.
D000293:Adolescent; D000328:Adult; D003956:Dialysis; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D008297:Male; D008875:Middle Aged; D010264:Paraplegia / Q000652:urine*
D006909:Hydroxyproline
Etude de l'excrétion urinaire de l'hydroxyproline totale libre et conjuguée non dialysable chez les sujets paraplégiques.