Electrophoretic evidence that GLO2 is the ancestral allele at the glyoxalase-I locus in humans.
Glyoxalase-I (EC 4.4.1.5) is polymorphic in humans but not in the closely related hominoid species, Pan troglodytes (the common chimpanzee). The electrophoretic mobility of chimpanzee glyoxalase-I is identical to that of human GLO2, as is that of another Old World primate, Macaca fasicularis. These evidences suggest that GLO2 may be the ancestral allele at this locus in hominoids. The significance of the human GLO variation is discussed in the light of other recent findings showing balanced polymorphism at this locus.
D000483:Alleles; D000818:Animals; D005075:Biological Evolution; D004912:Erythrocytes / Q000201:enzymology; D005796:Genes; D006801:Humans; D007791:Lactoylglutathione Lyase / Q000097:blood / Q000235:genetics*; D008190:Lyases / Q000235:genetics*; D008252:Macaca fascicularis; D002679:Pan troglodytes; D011110:Polymorphism, Genetic; D013045:Species Specificity
D008190:Lyases; D007791:Lactoylglutathione Lyase