Inhibition of mouse skin tumor promotion by several inhibitors of arachidonic acid metabolism.
12-O-Tetradecanoylphorbol-13-acetate promotion of skin tumors in mice can be inhibited by topical application of either the phospholipase A2 inhibitor dibromoacetophenone or the cyclooxygenase-lipoxygenase inhibitors 5,8,11,14-eicosatetrayonic acid or 1-phenyl-3-pyrazolidinone. The phospholipase A2 inhibitors in particular appear to be among the most potent inhibitors of skin tumor promotion known. These results support the hypothesis that at least some of the products of arachidonic acid transformation are essential for tumor promotion.
D015117:5,8,11,14-Eicosatetraynoic Acid / Q000494:pharmacology; D000098:Acetophenones / Q000494:pharmacology; D000818:Animals; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors / Q000378:metabolism*; D001711:Biotransformation; D005260:Female; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism; D010105:Oxygenases / Q000037:antagonists & inhibitors; D010212:Papilloma / Q000139:chemically induced; D010704:Phorbols / Q000037:antagonists & inhibitors*; D010740:Phospholipases / Q000037:antagonists & inhibitors*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors*
D000098:Acetophenones; D001095:Arachidonic Acids; D010704:Phorbols; D011448:Prostaglandin Antagonists; D011720:Pyrazoles; D015117:5,8,11,14-Eicosatetraynoic Acid; D010105:Oxygenases; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2; C015429:phenidone; D013755:Tetradecanoylphorbol Acetate