[Acetylation phenotype of isoniazid in Morocco. Preliminary study of 100 cases].
A preliminary study to determine the acetylator phenotype for Isoniazid was carried out for the first time on 100 patients. A correlation was shown between the blood and urinary methods; 59% were rapid acetylators and 41% slow acetylators, which were similar levels to those found in Black Africa. The predominance of rapid acetylators certainly explains the excellent tolerance of the high dose of INH (10 mg/kg) used in Morocco. If the determination of the acetylator phenotype could not be used systematically in our country, in view of the individual adaptation to the dosage--the dosage might, on the other hand be worked out in a prompt way before toxic signs appear at a dose of 10 mg/kg or under, of INH--thanks to the calculation of the index of inactivation estimated from a single sample.
D000107:Acetylation; D004361:Drug Tolerance; D006801:Humans; D007538:Isoniazid / Q000097:blood* / Q000652:urine; D009018:Morocco; D010641:Phenotype; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
D007538:Isoniazid
Phénotype d'acétylation de l'isoniazide au Maroc. Etude préliminaire sur 100 cas.