[Effect of phenothiazine derivatives on the development of experimental traumatic brain edema].
The effect of levomepromazin, propazin, diprazin and dyphenhydramine on the development of traumatic edema of the brain has been studied. Phenothiazine derivatives with an unbranched dialkylaminoalkyl side chain at the nitrogen atom (propazin) have been found to produce the most remarkable antiedematic action. The drugs that have a branched dialkylaminoalkyl chain (levomepromazin, diprazin) do not return brain water content to normal.
D000818:Animals; D001929:Brain Edema / Q000188:drug therapy*; D001930:Brain Injuries / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D010640:Phenothiazines / Q000627:therapeutic use*; D051381:Rats
D010640:Phenothiazines
Vliianie proizvodnykh fenotiazina na razvitie travmaticheskogo oteka golovnogo mozga v éksperimente.