Malignant hyperthermia in a myopathic child. Prolonged postoperative course requiring dantrolene.
An 18-month-old boy with congenital muscular dystrophy began to develop clear signs of the malignant hyperthermia syndrome after 85 min of halothane/nitrous oxide anaesthesia. Dantrolene, 2 mg/kg i.v., was immediately effective, but temperature, heart rate and carbon dioxide production were all increased for 2 days postoperatively in spite of repeated dantrolene administration.
D003620:Dantrolene / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008305:Malignant Hyperthermia / Q000188:drug therapy / Q000209:etiology*; D009136:Muscular Dystrophies / Q000150:complications* / Q000151:congenital / Q000601:surgery; D011183:Postoperative Complications
D003620:Dantrolene