In vivo pharmacokinetics of triazinate in L-1210 and W-256 cells.
A pharmacokinetic model for triazinate uptake in L-1210 cells in mice and W-256 cells in rats was developed to describe the observed concentration profiles with time in these cells following a 36 mg/m2 ip injection. The L-1210 cell permeability to triazinate was found to the approximately or 15 times smaller compared with W-256 cells. Similarly, the partition coefficient for L-1210 cells was calculated to be approximately or 175 times smaller than for W-256 cells. Cell membrane permeability appears to be the key parameter determining the drug transport at a short time after injection.
D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism*; D002279:Carcinoma 256, Walker / Q000378:metabolism*; D002463:Cell Membrane Permeability; D002478:Cells, Cultured; D007700:Kinetics; D007939:Leukemia L1210 / Q000378:metabolism*; D008297:Male; D008954:Models, Biological; D051381:Rats; D013997:Time Factors; D014227:Triazines / Q000378:metabolism*
D000970:Antineoplastic Agents; D014227:Triazines; C012071:triazinate