Hypophysectomy reduces the haloperidol-induced changes in striatal dopamine receptor density.
The ability of haloperidol (HAL) at doses of 1, 2 and 4 mg/kg to increase the density of the striatal dopamine (DA) receptors was measured in normal and hypophysectomized (Hypox) male rats. In intact rats HAL significantly increased the receptor density at all three doses. In Hypox rats HAL produced significantly less of an increase, with only the 4 mg/kg dose producing a statistically significant increase. Therefore, Hypox appears to reduce the ability of HAL to increase striatal DA receptor density.
D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight; D003342:Corpus Striatum / Q000032:analysis*; D006220:Haloperidol / Q000494:pharmacology*; D007016:Hypophysectomy; D008297:Male; D011388:Prolactin / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000032:analysis* / Q000187:drug effects
D011954:Receptors, Dopamine; D011388:Prolactin; D006220:Haloperidol