title: HLA and ophthalmic disease associations: a critical review and improved method for statistical analysis.
abstract: A critical review of published ophthalmic histocompatibility antigen association studies found numerous conflicting or ambiguous reports. Methodologic errors that could account for these discrepancies were categorized into 3 groups (1) arbitrary application of statistical methods to determine significance, (2) poor sampling design, and (3) variable disease definition. Multivariate analysis, not previously applied in this area provides a more powerful tool for assessing statistical significance. A computer program using this methodology for large studies is now available.
mesh_terms: D003201:Computers; D005128:Eye Diseases / Q000209:etiology / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D008722:Methods; D012306:Risk; D013223:Statistics as Topic
chemical_list: D006680:HLA Antigens