Evidence for genetic correlation of hypnotic effects and cerebellar Purkinje neuron depression in response to ethanol in mice.
In the present study, we compared phenotypic differences in behavioral and neurophysiological responses to acute ethanol administration among eight inbred strains of mice. Genetic variation for behavioral sedation, as measured by loss of the righting reflex (sleep time) after a hypnotic dose of ethanol, was shown to be present among the inbred strain population. In addition, a large genetic component of variation in the depressant action of ethanol on the spontaneous discharge of cerebellar Purkinje neurons was found. Results from an analysis of covariance of the behavioral and electrophysiological phenotypes, measured on each mouse among the inbred strains, provided strong evidence for a high genetic correlation between sleep time and inhibition of cerebellar Purkinje neuron discharge in response to acute ethanol administration. Taken together with our previously reported data on ethanol-induced electrophysiological changes in selectively bred lines, the results described here strongly support the hypothesis that the cerebellar Purkinje neuron is one important locus for the acute soporific effects of alcohol.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003864:Depression, Chemical; D004594:Electrophysiology; D000431:Ethanol / Q000494:pharmacology*; D006993:Hypnotics and Sedatives; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D011689:Purkinje Cells / Q000187:drug effects*; D012890:Sleep / Q000187:drug effects; D013045:Species Specificity
D006993:Hypnotics and Sedatives; D000431:Ethanol