Cellular aspects of the action of cytosine arabinoside.
The cellular effects of Ara-C are reviewed including its S-phase sensitivity, its proliferative-dependent cytotoxicity and progression delay effects which result in unbalance growth. Both direct and indirect cytotoxic mechanisms are discussed. The impact of such cellular information on the scheduling of Ara-C is presented with regard to normal and tumor cell population cytotoxicity. Based on these data a therapeutic rationale is presented.
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D004261:DNA Replication / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy
D003561:Cytarabine