Lack of effect of methylprednisolone on cardiac neural discharge associated with coronary occlusion-induced arrhythmia and death.
Methylprednisolone (30 or 50 mg/kg i.v.) was given 30 min prior to acute coronary occlusion of the left anterior descending artery. Neither dose of methylprednisolone exerted any effect on the mean postganglionic cardiac sympathetic nerve discharge prior to coronary occlusion and did not eliminate the nonuniform i.e., increased and/or decreased, neural discharge associated with occlusion-induced arrhythmia. Pretreatment with methylprednisolone did not increase the time to arrhythmia or death and did not decrease the number of cats dying after acute coronary occlusion.
D000704:Analysis of Variance; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000517:prevention & control*; D001794:Blood Pressure; D002415:Cats; D003327:Coronary Disease / Q000150:complications* / Q000503:physiopathology; D006321:Heart / Q000294:innervation*; D006339:Heart Rate; D008775:Methylprednisolone / Q000627:therapeutic use*; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D008775:Methylprednisolone