title: Biological properties of 3-benzyl-1,2-benzisothiazole compounds.
abstract: By reaction of 3-chloro-1,2-benzisothiazole with phenylacetonitrile, 3-benzyl-1,2-benzisothiazole derivatives can be obtained. These compounds seem to mimic the benzylisoquinoline structure so they can exhibit spasmolytic activities. Both antimuscarinic and direct muscle-relaxant properties have been found with N,N-dimethyl-3-phenyl-3-(1,2-benzisothiazol-3-yl) propylamine hydrochloride.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D010276:Parasympatholytics / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D009125:Muscle Relaxants, Central; D010276:Parasympatholytics; D013844:Thiazoles; D006632:Histamine; D000109:Acetylcholine