Studies on hemoglobinuria produced by venom from the Australian snake Tropidechis carinatus (rough-scaled snake).
Hemoglobinuria occurs in rats, but not in mice, after i.p. application of Tropidechis carinatus venom. By gel filtration on Sephadex G-75 and G-50 and chromatography on SP-Sephadex C-25 and DEAE-cellulose, a coagulant factor and a phospholipase A were isolated from the venom which in combination only, produced hemoglobinuria.
D000818:Animals; D002850:Chromatography, Gel; D003029:Coagulants / Q000032:analysis; D004546:Elapid Venoms / Q000032:analysis / Q000633:toxicity*; D006456:Hemoglobinuria / Q000139:chemically induced*; D010741:Phospholipases A / Q000032:analysis; D051381:Rats
D003029:Coagulants; D004546:Elapid Venoms; D010741:Phospholipases A