Glucose-sensitive afferent nerve fibres in the hepatic branch of the vagus nerve in the guinea-pig.
1. Afferent discharges were recorded from nerve filaments dissected from the hepatic branch of the vagus nerve in the guinea-pig in situ. 2. A significant decrease in the discharge rate was observed following the administration of D-glucose into the portal vein but not after the administration of D-mannose, D-fructose, D-galactose, L-glucose, D-xylose or D-arabinose. 3. The mean discharge rate of these fibres was inversely related to the concentration of glucose in the portal blood. 4. These results suggest the existence of D-glucose 'sensors' in the liver which monitor the glucose concentration of portal blood.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002628:Chemoreceptor Cells / Q000502:physiology; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D006168:Guinea Pigs; D006601:Hexoses / Q000494:pharmacology; D008099:Liver / Q000294:innervation*; D008297:Male; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology*; D010429:Pentoses / Q000494:pharmacology; D014630:Vagus Nerve / Q000502:physiology*
D001786:Blood Glucose; D006601:Hexoses; D010429:Pentoses; D005947:Glucose