title: Lung cancer excess in an abandoned lead-zinc mining and smelting area.
abstract: Analysis of cancer mortality in whites has revealed a significant excess in both males and females in an old lead/zinc mining and smelting area. This area consists of three rural contiguous counties: Cherokee County, Kansas, Jasper County, Missouri, and Ottawa County, Oklahoma. The lung cancer excess has persisted for at least 28 years for males and 5 years for females. A pilot case/control study is underway in Cherokee County to assess the influence of cigarette smoking, occupation, and residence on the lung cancer excess. Analysis will incorporate the histologic findings. From an environmental perspective, there are numerous mine tailings containing lead, zinc, cadmium, sulfur, germanium, and other chemicals. Considerable dust is airborne. Numerous openings (sink holes and bore holes) connect the old mines with the surface. Radium 226 has been detected in the untreated groundwater.
mesh_terms: D002274:Carcinogens, Environmental / Q000633:toxicity*; D004785:Environmental Pollutants / Q000633:toxicity*; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007854:Lead; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008906:Mining; D012737:Sex Factors; D015032:Zinc
chemical_list: D002274:Carcinogens, Environmental; D004785:Environmental Pollutants; D007854:Lead; D015032:Zinc