title: "Nutritional insurance" supplementation and corticosteroid toxicity.
abstract: Specialized "nutritional insurance" supplementation may reduce the risk of many important complications of long-term corticosteroid treatment. Supplementation with calcium, fluoride, activated vitamin D metabolites, and GTF, should help prevent osteoporosis. GTF, vitamin C, zinc and fluoride might help offset the inhibitory effect of corticosteroids on fibroblast and osteoblast function. Diabetic, hyperlipidemic and protein-losing effects might be compensated with supplementary GTF. Antioxidant nutrients could support humoral immunity and neutrophil function, while complementing the anti-inflammatory actions of corticosteroids. Supplementary magnesium could reduce the risk of nephrocalcinosis and nephrolithiasis.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000596:Amino Acids / Q000008:administration & dosage; D001205:Ascorbic Acid / Q000008:administration & dosage; D002857:Chromium / Q000008:administration & dosage; D003920:Diabetes Mellitus / Q000139:chemically induced; D004311:Double-Blind Method; D005459:Fluorides / Q000008:administration & dosage; D005527:Food, Fortified; D006801:Humans; D006887:Hydroxycholecalciferols / Q000008:administration & dosage; D006949:Hyperlipidemias / Q000139:chemically induced; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced; D009397:Nephrocalcinosis / Q000139:chemically induced; D009539:Nicotinic Acids / Q000008:administration & dosage; D009751:Nutritional Requirements; D010024:Osteoporosis / Q000139:chemically induced / Q000517:prevention & control; D012643:Selenium / Q000008:administration & dosage; D012825:Silicon / Q000008:administration & dosage
chemical_list: D000305:Adrenal Cortex Hormones; D000596:Amino Acids; D006887:Hydroxycholecalciferols; D009539:Nicotinic Acids; C015240:glucose tolerance factor; D002857:Chromium; D012643:Selenium; D001205:Ascorbic Acid; D005459:Fluorides; D012825:Silicon