Advanced carcinoma of the cervix treated by continuous pelvic arterial infusion with cytostatics and radiation therapy.
Regional chemotherapy by infusion of cytostatic drugs (methotrexate and adriamycin) into the hypogastric arteries has been used in 25 cases of advanced carcinoma of the cervix (IIIB and IV stage). A method for the percutaneous introduction of catheters into these arteries and their permanence for a period of time of 8-12 days is described. After chemotherapy there was such a satisfactory reduction in size of the tumour that patients could then be treated with radiotherapy and/or surgery.
D004317:Doxorubicin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008727:Methotrexate / Q000008:administration & dosage*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy
D004317:Doxorubicin; D008727:Methotrexate