[Clinical heterogeneity in fructose intolerance].
We observed eight infants with hereditary fructose intolerance which had been diagnosed by the fructose tolerance test and an aldolase assay on biopsied liver. None of these had been diagnosed before their admission to our department. The most frequent symptoms were vomiting and failure to thrive. All the patients had hepatomegaly. Laboratory findings were indicative of disturbed hepatic function. Hypoglycemia was found in only 3 out of 8 patients. The course was lethal in 2 patients; the 6 survivors are doing well following a fructose-free diet. The importance of practising paediatricians having the detailed nutritional history of the patient and precise knowledge of infant food formulae is stressed. The danger of using fructose continuing solutions for infusion therapy is pointed out. We also report a case of F-1,6-diphosphatase deficiency.
D002239:Carbohydrate Metabolism, Inborn Errors / Q000175:diagnosis*; D005260:Female; D005631:Fructokinases / Q000172:deficiency; D005632:Fructose / Q000378:metabolism; D005633:Fructose Intolerance / Q000175:diagnosis* / Q000201:enzymology / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male
D005632:Fructose; D005631:Fructokinases
Eterogeneità clinica nell'intolleranza al fruttosio.