[Epidemiological significance, clinico-morphological evaluation and behavior of pathogenetic factors, in asymptomatic chronic carriers of the HBsAg in the La Plata area. Study in voluntary blood donors].
Seric positivity for HBsAg (CIED) investigated on 100.000 volunteer blood donors of La Plata city was 0.239%. Humoral findings on 40 cases only revealed TGO-TGP seric levels over twice the normal in 15 and 10% respectively. On 27 biopsied patients, chronic active hepatitis in one case and chronic persistent hepatitis in another one were found. Non-specific chronic inflammatory changes were seen in 18.5%. Correlation between TGO-TGP levels and histologic damage was generally proved. HBeAg seric positivity in 3/29 cases (10.3%) was accompanied of both raised TGO-TGP levels and some kind of chronic inflammatory change. Statistic high risk was determined for both O-Rh negative blood group and HLA-Bw21 individuals. Diminished cutaneous PPD reactivity without significative alteration of linfocite population was established.
D000328:Adult; D001782:Blood Donors; D001789:Blood Group Antigens; D002353:Carrier State / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006509:Hepatitis B / Q000097:blood / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D007111:Immunity, Cellular; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012397:Rosette Formation; D012698:Serologic Tests; D000637:Transaminases / Q000097:blood
D001789:Blood Group Antigens; D006680:HLA Antigens; D006514:Hepatitis B Surface Antigens; D000637:Transaminases
Significación epidemiológica, valoración clínico-morfológica y comportamiento de factores patogenéticos, en portadores crónicos asintomáticos del HBsAg en el área de La Plata. Estudio en donantes voluntarios de sangre.