title: Induction of chromosome aberrations by phenobarbitone in the germ cells of Swiss male mice.
abstract: The cytogenetic effects of phenobarbitone were studied in the male germ cells of Swiss mice. The drug was orally administered at 42, 84 and 126 mg/kg body weight dose levels by sub-acute and chronic modes of treatment. In the treated series, the incidence of chromosome aberrations was significant at all dose levels. However, there were no significant differences between sub-acute and chronic treatments in the incidence of chromosome aberrations. The results clearly demonstrate the ability of phenobarbitone to induce chromosome damage in the germ cells of male mice.
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D008297:Male; D051379:Mice; D010634:Phenobarbital / Q000633:toxicity*; D012730:Sex Chromosomes / Q000187:drug effects; D013090:Spermatocytes / Q000166:cytology / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects*
chemical_list: D010634:Phenobarbital