title: [Personal experiences in the long-term treatment of cystine lithiasis with high-dose ascorbic acid].
abstract: We report on our experience with 9 cystine-lithiasis patients who were treated with large doses of ascorbic acid (5 g/day) for periods ranging from 6-27 months. We observed recidive lithogenesis in only 3 patients during this time. The influence of ascorbic acid on the excretion of cystine and oxalate in the urine is discussed. A lack of side effects and the significantly lower frequency of recidivation justify the further use of ascorbic as an alternative medication in cystine lithiasis.
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000627:therapeutic use*; D003553:Cystine; D003555:Cystinuria / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010070:Oxalates / Q000652:urine; D019815:Oxalic Acid; D012008:Recurrence; D001744:Urinary Bladder Calculi / Q000188:drug therapy; D014545:Urinary Calculi / Q000188:drug therapy* / Q000652:urine
chemical_list: D010070:Oxalates; D003553:Cystine; D019815:Oxalic Acid; D001205:Ascorbic Acid
vernacular_title: Unsere Erfahrungen bei der Langzeitbehandlung des Zystinsteinleidens mit hochdosierter Askorbinsäure.