title: [Clometacin--2. Metabolism and bioavailability in the monkey and in man].
abstract: Contrarily to the rat (see part I), clometacin is not metabolized in the monkey and in man. Urinary elimination is greater in the monkey (80 to 90% of the administered drug) than in humans (14 to 33%). Urinary excretion is rapid, i.e. more than 80% within the 24 first hours. Retention of the drug by any organ was not detected in the monkey.
mesh_terms: D000328:Adult; D000818:Animals; D001682:Biological Availability; D005260:Female; D006801:Humans; D007210:Indoleacetic Acids / Q000378:metabolism* / Q000652:urine; D008251:Macaca; D008297:Male; D014018:Tissue Distribution
chemical_list: D007210:Indoleacetic Acids; C017136:clometacin
vernacular_title: Travaux sur la clométacine--2e partie. Métabolisme et biodisponibilité chez le singe et chez l'homme.