Unscheduled DNA synthesis in rat liver after gastric administration of halothane.
Unscheduled DNA replication occurred in response to halothane administered to rats by stomach tube. This response was observed under a narrow range of experimental conditions that included pretreatment with phenobarbital and a short interval between barbiturate and anesthetic administration. Under the conditions of the experiment, hepatic necrosis was not demonstrable.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis*; D006221:Halothane / Q000008:administration & dosage / Q000633:toxicity*; D006918:Hydroxyurea / Q000494:pharmacology; D007441:Intubation, Gastrointestinal; D008099:Liver / Q000378:metabolism*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013936:Thymidine / Q000378:metabolism
D004247:DNA; D006221:Halothane; D013936:Thymidine; D006918:Hydroxyurea; D010634:Phenobarbital