Opiate and norepinephrine-induced feeding from the paraventricular nucleus of the hypothalamus are dissociable.
Microinjection of d-ala-met-enkephalinamide (DALA) or norepinephrine (NE) into the paraventricular nucleus of the hypothalamus (PVN) elicits feeding. Manipulation of the pituitary-adrenal axis by dexamethasone or adrenalectomy is shown to alter NE- but not DALA-induced feeding. DALA-induced feeding is probably not due to activation of the glucocorticoid sensitive NE feeding system nor due to glucocorticoid-sensitive beta-endorphin release from the anterior pituitary.
D000315:Adrenalectomy; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C030279:enkephalinamide-Leu, Ala(2)-; D003907:Dexamethasone; D009638:Norepinephrine