Effect of chlorpromazine on contact hypersensitivity to DNCB in the guinea-pig.
Chlorpromazine, a phenothiazine derivative useful in the treatment of various mental disorders, was found to depress contact hypersensitivity to dinitrochlorobenzene in guinea-pigs. This drug proved equipotent on the various phases of this delayed-type immune response. The observed immunodepression is consistent with previously reported untoward reactions to chlorpromazine and might have consequences which deserve further evaluation in the management of psychiatric patients.
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D003877:Dermatitis, Contact / Q000188:drug therapy*; D004137:Dinitrochlorobenzene; D005260:Female; D006168:Guinea Pigs; D007111:Immunity, Cellular / Q000187:drug effects*; D009578:Nitrobenzenes
D004137:Dinitrochlorobenzene; D009578:Nitrobenzenes; D002746:Chlorpromazine