[Effect of different doses of dexamethasone on the course of brain injuries in animals sensitized to nerve tissue antigens].
The effect of different dexamethasone doses on the development of edema of the brain in its injury was studied on 79 rabbits, controls and those sensitized with the brain antigen. The local cerebral circulation and the total tissue fluid in the perifocal region of the injured grey and white matter of the rabbit's cerebral hemispheres were studied; EEG was recorded and ultrastructural study of the nervous tissue in the zone of the trauma at the level of the ultrastructures was conducted. The examination showed that dexamethasone had a favourable therapeutic effect on the course of the brain trauma in the early periods after it was inflicted; the agent reduced edema of the brain tissue, which was especially manifest in animals with altered immunological reactivity of the organism. The best effect in these animals was caused by large doses of dexamethasone.
D000818:Animals; D001921:Brain / Q000276:immunology* / Q000648:ultrastructure; D001929:Brain Edema / Q000517:prevention & control*; D001930:Brain Injuries / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D002560:Cerebrovascular Circulation; D002682:Chinchilla; D003907:Dexamethasone / Q000008:administration & dosage*; D006967:Hypersensitivity / Q000150:complications; D008854:Microscopy, Electron
D003907:Dexamethasone
Vliianie razlichnykh doz deksametazona na techenie travmy mozga u zhivotnykh, sensibilizirovannykh k antigenam nervnoĭ tkani.