Acute hemodynamic effects of intravenous tiapamil in patients with coronary artery disease.
The acute hemodynamic effects of intravenous tiapamil were studied during heart catheterization in 19 patients with coronary artery disease (age range 41-66 years, mean 52.4 years). 10 subjects received an initial intravenous loading dose of 1 mg/kg followed by intravenous infusion of 50 micrograms/kg/min for 15 min. The other 9 patients received an initial intravenous dose of 1.5 mg/kg which was followed by an intravenous infusion of 75 micrograms/kg/min for 15 min. Tiapamil had little effect on heart rate, intracardiac pressures and left ventricular dp/dtmax. The ejection fraction increased, but not significantly. The most striking findings were an increase in cardiac output and a decrease in systemic vascular resistance. The overall results are consistent with the drug's propensity to produce peripheral vasodilatation which outweighs its intrinsic negative inotropic property due to calcium antagonism in myocardial tissues.
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy / Q000503:physiopathology; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D006328:Cardiac Catheterization; D002302:Cardiac Output / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology; D011437:Propylamines / Q000494:pharmacology*; D013318:Stroke Volume / Q000187:drug effects; D013976:Tiapamil Hydrochloride; D014655:Vascular Resistance / Q000187:drug effects
D000889:Anti-Arrhythmia Agents; D011437:Propylamines; D013976:Tiapamil Hydrochloride