Formation of estradiol-17 beta fatty acyl 17-esters in mammary tumors.
Incubations of estradiol with human and MT/W9a-B rat mammary tumors showed the formation of a non-polar metabolite of estradiol linked with a fatty acid at the 17-position. Studies involving incubations of 3H-estradiol and 14C-stearic acid and 14C-oleic acid showed that these tumors formed both the oleoyl and stearyl esters of estradiol and that the percent of oleoyl ester present in the non-polar metabolite fraction ranged between 19% to 25% while that of stearyl ranged from 10% to 16%. The physiological significance of these results are discussed.
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism*; D004951:Esterification; D004958:Estradiol / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism*; D051381:Rats
D005227:Fatty Acids; D004958:Estradiol