title: A non-steroidal gametic factor linked to DNA modulates delta-aminolevulinic acid synthase inducibility acting on liver transcriptional and translational processes.
abstract: The effect of an acidic factor of low molecular weight (about 1,000 daltons), extracted from bovine spermatozoan DNA, on the inducibility of delta-aminolevulinic acid synthase by ethanol during aging in rat has been examined. The increased enzyme inducibility in 600-day old rats is supported by stimulation of transcriptional and translational processes; on the contrary, in 30-day old rats, the higher enzyme values induced by ethanol are significantly decreased after factor treatment. The active factor is strongly DNA-bound in the native spermatozoan DNA. This would imply a possible role in regulating gene expression in vivo.
mesh_terms: D000624:5-Aminolevulinate Synthetase / Q000096:biosynthesis*; D000375:Aging; D000818:Animals; D002417:Cattle; D004247:DNA / Q000502:physiology*; D004790:Enzyme Induction / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D008297:Male; D014176:Protein Biosynthesis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013094:Spermatozoa / Q000502:physiology*; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D000431:Ethanol; D004247:DNA; D000624:5-Aminolevulinate Synthetase