The effect of dominant hemimelia (Dh) genes on the number of mast cells in lymph nodes.
The total number of mast cells present in popliteal lymph nodes of hereditarily asplenic Dh/+ mice is lower than in their normal +/+ littermates. The lymph nodes are larger in Dh/+ mice than in normal +/+ littermates. It is postulated that the spleen in some way regulates the number of mast cells in the lymphoid cell population.
D000818:Animals; D002452:Cell Count; D003433:Crosses, Genetic; D005260:Female; D005799:Genes, Dominant; D006579:Heterozygote; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008407:Mast Cells / Q000166:cytology*; D051379:Mice; D008817:Mice, Mutant Strains; D013154:Spleen / Q000002:abnormalities*