title: Concurrent measurement of solvent vapor concentrations and effects on operant behavior using a dynamic exposure system.
abstract: A method is described for exposing mice, lever-pressing on an operant schedule for water reinforcement, to continuously-generated solvent vapors. Concurrent monitoring of chamber concentration and schedule-controlled behavior allows a correlation of the magnitude and time course for behavioral effects with changes in the levels of solvent exposure. Data are presented showing the acute effects of 1,1,1-trichloroethane over the range of 1000-8000 ppm on behavior maintained by a fixed-ratio 100 schedule of water presentation. Concentration-dependent decreases in response rates with a rapid onset and recovery were obtained.
mesh_terms: D000818:Animals; D001273:Atmosphere Exposure Chambers; D003216:Conditioning, Operant / Q000187:drug effects*; D008297:Male; D051379:Mice; D012997:Solvents / Q000032:analysis / Q000494:pharmacology*; D013997:Time Factors; D014240:Trichloroethanes / Q000494:pharmacology
chemical_list: D012997:Solvents; D014240:Trichloroethanes; C024566:1,1,1-trichloroethane