[Elevation of the threshold in the rabbit dental pulp test with coumarin: unspecified (local) effect rather than analgesic activity?].
The antinociceptive efficacy of Coumarin was tested in mice, rats, and rabbits. No increase in threshold for the antinociceptive reaction was observed in the hot plate test and tail flick response in mice and rats. Using the tooth pulp test in rabbits, the threshold for the licking reaction was increased. This effect was dose dependent and could, at least partially, be antagonized by Naloxone. Because there is no direct opiate-like activity of Coumarin, these results suggest that the effect may be mediated by the release of endogeneous opiate-like peptides. It remains totally unclear why this effect could only be demonstrated in one particular test in one species.
D000700:Analgesics; D000818:Animals; D003374:Coumarins / Q000494:pharmacology*; D003791:Dental Pulp Test; D004305:Dose-Response Relationship, Drug; D010146:Pain / Q000503:physiopathology*; D011817:Rabbits; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
D000700:Analgesics; D003374:Coumarins; C030123:coumarin
Reizschwellenerhöhung im Zahnpulpatest an Kaninchen durch Cumarin: Unspezifischer (lokaler) Effekt oder analgetische Wirkung?