In vitro antibacterial activity of different clotrimazole formulations.
The antibacterial activity of two different clotrimazole formulations was tested in vitro. A neutral vaginal tablet with 100 mg active ingredient has a partial bactericidal effect on gram-positive bacteria. A new formula containing 500 mg clotrimazole and lactic acid, designed for a one-dose therapy of vulvovaginal mycoses, shows an improved bactericidal activity against gram-positive bacteria and, owing to the lactic acid content, a broad bactericidal effect on gram-negative species.
D001419:Bacteria / Q000187:drug effects*; D002951:Citrates / Q000494:pharmacology; D003022:Clotrimazole / Q000008:administration & dosage / Q000494:pharmacology*; D004338:Drug Combinations; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000494:pharmacology*; D066298:In Vitro Techniques; D007773:Lactates / Q000008:administration & dosage / Q000494:pharmacology; D019344:Lactic Acid
D002951:Citrates; D004338:Drug Combinations; D007093:Imidazoles; D007773:Lactates; D019344:Lactic Acid; D003022:Clotrimazole