Characterization of a nonvirulent variant of lymphocytic choriomeningitis virus.
A cold-adapted, nonvirulent variant of the Armstrong strain of lymphocytic choriomeningitis virus was isolated from infected L929 cells maintained at 25 degrees C. This variant, designated P17, was capable of replicating in the central nervous system of mice without causing disease and conferring immunity to back challenge with the parental strain.
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D001921:Brain / Q000382:microbiology; D002478:Cells, Cultured; D004285:Dogs; D007700:Kinetics; D007739:L Cells; D008217:Lymphocytic choriomeningitis virus / Q000235:genetics* / Q000254:growth & development / Q000276:immunology; D051379:Mice; D009500:Neutralization Tests; D014779:Virus Replication
D000914:Antibodies, Viral