[Effect of morphine and promedol on oxygen metabolism in the skeletal muscles in various functional states].
It has been demonstrated in experiments on rats that in the skeletal muscle, morphine and promedol cause, during disconnection of efferent innervation with pavulon, a dose-dependent reduction in oxygen tension (OT) and an increase in the oxygen consumption rate constant (OCRC). During disconnection of the central mechanisms of muscle tone control with sodium thiopental, morphine and, to a greater degree, promedol decreased OT. The OCRC was markedly decreased under the effect of morphine in a dose of 25 mg/kg.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004525:Efferent Pathways / Q000187:drug effects; D008614:Meperidine / Q000031:analogs & derivatives*; D009020:Morphine / Q000494:pharmacology*; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects*; D010197:Pancuronium / Q000494:pharmacology; D011396:Promedol / Q000494:pharmacology*; D051381:Rats; D013874:Thiopental / Q000494:pharmacology; D013997:Time Factors
D011396:Promedol; D009020:Morphine; D008614:Meperidine; D010197:Pancuronium; D013874:Thiopental
Vliianie morfina i promedola na kislorodnyĭ obmen v skeletnykh myshtsakh pri ikh razlichnom funktsional'nom sostoianii.