Sister-chromatid exchange and chromosomal aberration induction in cultured Chinese hamster cells by the monomethylbenz[a]anthracenes.
The ability of the 12 monomethylbenz[a]anthracene isomers, following their metabolism by using the cell-mediated activation system, to induce 8-azaguanine-resistant mutants, sister-chromatid exchanges (SCEs) and chromosomal aberrations has been measured. Both the mutagenic potency and the ability of the monomethylbenz[a]anthracenes to induce SCEs correlated with their carcinogenic activity. None of the monomethylbenz[a]anthracenes were particularly clastogenic.
D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D003434:Crossing Over, Genetic / Q000187:drug effects*; D007668:Kidney; D008647:Mesocricetus; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D001551:Benz(a)Anthracenes; D009153:Mutagens