[In vitro availability of a topical corticosteroid from various vehicles. Attempt at a correlation with an in vivo study].
The object of the study is to show the availability of a topical corticosteroïd (difluprednate) from pharmaceutical forms: the gel and cream forms in which the substance is solubilised, the greasy and emulsified forms in which the substance is dispersed. The bioavailability of these forms dosed to 0.025% was evaluated by a cutaneous vasoconstriction test. The results show that the cutaneous penetration of difluprednate is more favourable in the gel and cream forms. The "in vitro" availability of commercial dosage forms (0.05% of difluprednate) and the "in vivo" results are compared and commented.
D001682:Biological Availability; D005477:Fluprednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D009824:Ointments; D014677:Pharmaceutical Vehicles
D009824:Ointments; D014677:Pharmaceutical Vehicles; D005477:Fluprednisolone; C015808:difluprednate
Etude de la disponibilité "in vitro" d'un corticostéroïde à usage topique à partir de différents véhicules. Essai de corrélation avec une étude "in vivo".