Fatty acid patterns in iron-deficient maternal and neonatal rats.
To determine the effects of maternal iron deficiency on lipid composition and fatty acid patterns in offspring, rats were fed ad libitum diets containing 5 ppm iron (deficient) (n=8) or 320 ppm iron (control) (n=7) and deionized water from day-1 of gestation through day-18 of lactation. On day-2 of lactation, litters were standardized to three male and three female pups. On day-18, pups were fasted for 4 hr before tissue and blood collection. Significant changes in serum and liver lipid concentrations and fatty acid patterns were observed in deficient pups. Serum triglycerides, cholesterol and phospholipids and liver triglycerides, cholesterol, and cholesteryl esters were increased. In deficient pups, percentage total fatty acids of 14:0, 16:1, 18:1, 18:2 from serum lipids were increased; in liver, 14:0, 18:2, 18:3 were increased; 18:0 and 20:4 were decreased in both serum and liver. Dam serum lipid levels did not differ between groups. Lipid changes observed in iron-deficient pups did not consistently reflect the milk, serum or liver lipid patterns observed in dams. Altered lipid composition and fatty acid patterns of iron-deficient pups thus appear to be of endogenous origin.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D005227:Fatty Acids / Q000032:analysis* / Q000097:blood; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D000090463:Iron Deficiencies; D008099:Liver / Q000032:analysis; D008892:Milk / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D005227:Fatty Acids; D006454:Hemoglobins