Stimulatory effects of dexamethasone and indomethacin on growth of androgen-dependent Shionogi carcinoma 115 in the mouse.
The effects of dexamethasone and indomethacin on the growth of androgen-dependent Shionogi carcinoma 115 were studied. When castrated male DS mice were treated with dexamethasone for 2 weeks at daily doses of 1-5 mg/kg starting from 3 days before tumor inoculation, the tumor weight as well as the transplantability was significantly increased. The tumor grown in dexamethasone-treated mice had morphological, biochemical and biological characteristics similar to those of the original Shionogi carcinoma 115. Indomethacin at daily doses of 2-10 mg/kg also stimulated the tumor growth in castrated DS mice, but the effect was less pronounced than that of dexamethasone. In allogeneic male ICR mice, dexamethasone promoted tumor growth, but indomethacin had no effect. These results suggest that tumor growth in the mouse is stimulated not only by androgens but also by glucocorticoids through the suppression of immune responses of the host and direct action on the tumor cells.
D000728:Androgens / Q000502:physiology*; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology / Q000473:pathology*; D009376:Neoplasms, Hormone-Dependent / Q000276:immunology / Q000473:pathology*
D000728:Androgens; D003907:Dexamethasone; D007213:Indomethacin