[The behavior of antidiarrheal drugs in experiments].
Four antidiarrheal drugs (China clay, bentonite, pectin, Kaoprompt H) are fed to mice by a gastric probe. Eight hours later, samples are taken from small intestine and colon to study the behaviour of the drugs in the gut. Any interactions with the brushborder of the villi at best are possible in the case of pectin. The viscosities of the suspended drugs depending on selected steps of pH are tested. The results are supporting the histological findings. The mechanical effects which may be put on the gut by the drugs are discussed.
D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology*; D001546:Bentonite / Q000494:pharmacology; D003106:Colon / Q000187:drug effects*; D004338:Drug Combinations / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000648:ultrastructure; D007421:Intestine, Small / Q000187:drug effects*; D007616:Kaolin / Q000494:pharmacology; D051379:Mice; D008871:Microvilli / Q000187:drug effects; D010368:Pectins / Q000494:pharmacology; D014783:Viscosity
D000930:Antidiarrheals; D004338:Drug Combinations; D001546:Bentonite; D007616:Kaolin; C035989:Kaoprompt H; D010368:Pectins
Das Verhalten antidiarrhoisch wirkender Substanzen im Experiment.