[Metabolic study of sarcoma 45 and Walker carcinosarcoma cells during growth and anticoagulant exposure. An autoradiographic study].
Intensity of DNA, RNA and protein synthesis was estimated autoradiographically in rat tumour cells of sarcoma 45 (S. 45) and Walker carcinosarcoma (WCS). It is shown that the DNA synthesis reduces with tumour growth, the RNA synthesis in growing S.45 increases. The level of nucleic acid synthesis is higher in metastatic cells of WCS than in the initial transplant. DNA, RNA and protein synthesis in neoplastic cells decreases under anticoagulant treatment.
D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use*; D001345:Autoradiography; D002279:Carcinoma 256, Walker / Q000188:drug therapy / Q000378:metabolism*; D004273:DNA, Neoplasm / Q000378:metabolism; D006487:Hemostasis / Q000187:drug effects; D008297:Male; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000378:metabolism; D009368:Neoplasm Transplantation; D012334:RNA, Neoplasm / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000378:metabolism*; D013997:Time Factors
D000925:Anticoagulants; D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm
Issledovanie metabolizma kletok sarkomy 45 i kartsinosarkomy Uoker v protsesse ikh rosta i pri antikoaguliantnom vozdeĭstvii. Avtoradiograficheskoe issledovanie.