The formation of N-alkylprotoporphyrin IX and destruction of cytochrome P-450 in the liver of rats after treatment with 3,5-diethoxycarbonyl-1,4-dihydrocollidine and its 4-ethyl analog.
D000478:Alkylation; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003997:Dicarbethoxydihydrocollidine / Q000031:analogs & derivatives / Q000494:pharmacology*; D005294:Ferrochelatase / Q000037:antagonists & inhibitors; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D011166:Porphyrins / Q000378:metabolism*; D011524:Protoporphyrins / Q000378:metabolism*; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011166:Porphyrins; D011524:Protoporphyrins; D011725:Pyridines; C030826:3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine; D003997:Dicarbethoxydihydrocollidine; D003577:Cytochrome P-450 Enzyme System; C028025:protoporphyrin IX; D005294:Ferrochelatase