[Effect of polyene antibiotics on the development of alcoholic-dietary fatty degeneration of the liver in rats].
The effect of the sodium salts of levorin, isolevorin, nystatin and amphotericin B prepared with the use of sodium desoxycholate and amphoglucamine on the development of fatty degeneration of the liver was studied in rats. Fatty degeneration of the liver was induced in the animals by the diet deficient in choline and administration of alcohol (10 g/kg). Most of the studied antibiotics inhibited the development of the liver fatty degeneration. The only exclusion was amphotericin B prepared with the use of sodium desoxycholate which did not influence the level of the liver fatty degeneration. Sodium levorin (10 mg/kg) produced the most pronounced normalizing effect on the lipid metabolism in the liver. Complication of mycoses with fatty degeneration of the liver should not be considered as a contraindication to their treatment with polyenic antibiotics.
D000666:Amphotericin B / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002174:Candicidin / Q000627:therapeutic use; D002796:Choline Deficiency / Q000150:complications; D004353:Drug Evaluation, Preclinical; D005234:Fatty Liver / Q000188:drug therapy* / Q000209:etiology; D005235:Fatty Liver, Alcoholic / Q000188:drug therapy; D008297:Male; D009761:Nystatin / Q000627:therapeutic use; D051381:Rats
D000900:Anti-Bacterial Agents; D009761:Nystatin; D002174:Candicidin; C023999:amphoglucamine; D000666:Amphotericin B
Vliianie polienovykh antibiotikov na razvitie alkogol'no-alimentarnoĭ zhirovoĭ distrofii pecheni u krys.