Effect of diatrizoate meglumine (Hypaque) on the perilymphatic oxygen tension.
The effect of diatrizoate meglumine (Hypaque) upon the perilymphatic oxygenation has been investigated using the polarographic method in cats submitted to various conditions such as normoxia, apnea, hypercapnia and chronically reduced vascularization. The minimal changes of the perilymphatic PO2 recorded after the injection of Hypaque permit to conclude that this drug has no practical effect upon the oxygenation of the perilymph.
D000818:Animals; D002415:Cats; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000494:pharmacology*; D007761:Labyrinthine Fluids / Q000187:drug effects*; D010100:Oxygen / Q000032:analysis*; D010313:Partial Pressure; D010498:Perilymph / Q000187:drug effects*
D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D010100:Oxygen