Cimetidine does not alter morphine disposition in man.
1 The pharmacokinetic parameters of morphine were determined in a crossover fashion following 4 days pretreatment with cimetidine, 300 mg every 6 h, or placebo. 2 Cimetidine had no apparent effect on the mean morphine plasma clearance, volume of distribution, AUC or half-life (P greater than 0.05; power greater than 0.80). 3 Cimetidine had no apparent effect on the magnitude or duration of morphine induced miosis. 4 The absence of a demonstrable effect on the pharmacokinetics of a drug with a high extraction ratio such as morphine suggests that cimetidine did not significantly reduce hepatic blood flow in ambulant normal volunteers.
D000328:Adult; D002927:Cimetidine / Q000494:pharmacology*; D004347:Drug Interactions; D006146:Guanidines / Q000494:pharmacology*; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008102:Liver Circulation / Q000187:drug effects; D008297:Male; D009020:Morphine / Q000097:blood / Q000378:metabolism*; D011680:Pupil / Q000187:drug effects
D006146:Guanidines; D009020:Morphine; D002927:Cimetidine