[Action of tamoxifen on the sex organs of guinea pigs].
Long-term administration of tamoxifen (3-5 months) in a dose of 0.4 mg/kg to guinea-pigs with estrogen-induced benign uterine tumors had no toxic effects on the animals. Tamoxifen caused no noticeable changes in the ovarian mass, however, 40% of the guinea-pigs manifested ovulation suppression. Analysis of vaginal smears showed that most animals were in the stage of unestrus. Long-term administration of tamoxifen alone did not lead to the development of uterine polyps or tumors. Tamoxifen alone or combined with synestrol provoked a marked decrease in the level of free cytoplasmic estrogen and glucocorticoid receptors in the uterines of the guinea-pigs. In the course of long-term administration of tamoxifen alone, a tendency towards progesterone receptor decrease in the uterus was demonstrated.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004028:Dienestrol / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D006168:Guinea Pigs; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects*; D011987:Receptors, Steroid / Q000187:drug effects; D013629:Tamoxifen / Q000627:therapeutic use*; D013997:Time Factors; D014594:Uterine Neoplasms / Q000188:drug therapy; D014599:Uterus / Q000187:drug effects*
D011987:Receptors, Steroid; D013629:Tamoxifen; D004028:Dienestrol
Deĭstvie tamoksifena na polovye organy morskikh svinok.