Ovarian Sertoli-Leydig cell tumor with rhabdomyosarcoma: an ultrastructural study.
The clinical and light and electron microscopic findings of a moderately differentiated, virilizing, Sertoli-Leydig cell tumor (SLT) with pleomorphic rhabdomyosarcoma of the ovary are presented. The tumor recapitulates the primitive embryonal testis and rhabdomyogenesis, respectively. The natural history, including pathogenesis, of this peculiar and rare tumor is discussed in the light of the pertinent literature on SLT and ovarian rhabdomyosarcoma. It seems that when rhabdomyosarcoma is a significant or predominant component of SLT, as occurred in this case, the prognosis is poor and is that of rhabdomyosarcoma in general.
D000293:Adolescent; D005260:Female; D006801:Humans; D007984:Leydig Cell Tumor / Q000473:pathology / Q000648:ultrastructure*; D008854:Microscopy, Electron; D009378:Neoplasms, Multiple Primary / Q000648:ultrastructure*; D010051:Ovarian Neoplasms / Q000473:pathology / Q000648:ultrastructure*; D012208:Rhabdomyosarcoma / Q000473:pathology / Q000648:ultrastructure*; D012707:Sertoli Cell Tumor / Q000473:pathology / Q000648:ultrastructure*