Assessment of drugs for activity in established type II collagen arthritis.
Arthritis was induced in a proportion of rats sensitized with type II collagen and Freund's incomplete adjuvant. Rats which developed arthritis had significantly higher antibody titres and significantly greater delayed hypersensitivity responses to type II collagen than rats which did not develop arthritis. Anti-inflammatory and anti-rheumatic drugs were evaluated against type II collagen arthritis. Dexamethasone reduced inflammatory swelling, reduced both the antibody titre and delayed hypersensitivity to type II collagen and exerted joint protection. Indomethacin reduced inflammatory swelling. Azathioprine, Clozic, Levamisole, D-Penicilamine and Sulphapyridine did not exert significant beneficial activity in this test.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000917:Antibody Formation; D001168:Arthritis / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000276:immunology; D003094:Collagen / Q000276:immunology*; D003907:Dexamethasone / Q000627:therapeutic use; D004195:Disease Models, Animal; D004341:Drug Evaluation; D005260:Female; D006968:Hypersensitivity, Delayed; D010396:Penicillamine / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone; D003094:Collagen; D010396:Penicillamine