Neutropenia fails to prevent the acute phase stimulation of fibrinogen synthesis.
This study evaluates the role of neutrophil granulocytes in mediating acute phase stimulation of fibrinogen synthesis. Turpentine was administered to neutropenic and non-neutropenic rats and fibrinogen synthetic rates measured in an isolated liver perfusion system. Using the (14C) carbonate technique for the measurement of the absolute synthetic rates of liver produced plasma proteins it was observed that the rates of fibrinogen synthesis of the neutropenic and non-neutropenic rats were significantly greater (p less than 0.01) than those of normal control animals, but were not significantly different from each other. These results suggest that the neutrophil granulocyte may not be of major importance in mediating acute phase stimulation of fibrinogen synthesis.
D000380:Agranulocytosis / Q000378:metabolism*; D000818:Animals; D002250:Carbon Radioisotopes; D005340:Fibrinogen / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism; D008297:Male; D008466:Mechlorethamine; D009503:Neutropenia / Q000139:chemically induced / Q000378:metabolism*; D009504:Neutrophils / Q000502:physiology*; D051381:Rats; D012709:Serum Albumin / Q000096:biosynthesis; D013997:Time Factors; D014425:Turpentine
D002250:Carbon Radioisotopes; D012709:Serum Albumin; D008466:Mechlorethamine; D005340:Fibrinogen; D014425:Turpentine