[Supportive testosterone treatment in surgical repair of hypospadias].
Hypoplastic development of the phallus renders repair of hypospadias more difficult and very often limits functional and cosmetic results. We therefore tried to simplify surgery and to improve results by perioperative low-dose intramuscular testosterone treatment. 9 children with hypospadias of varying degree were treated with testosterone enantate 25-250 mg x 3 (2 injections at 3 weeks intervals preop. and 1 injection postop). Bone age, growth and phallic development were followed up to 2 years. While there was a reliable degree of phallic growth in most of the boys, in only 3 of the children we observed a slight transitory acceleration of skeletal development, in 7 a transitory increase of growth rate. No signs of virilisation were noted. We believe that in selected cases of hypospadias a short-term low-dose testosterone treatment may be an acceptable means to simplify and improve repair.
D000293:Adolescent; D002648:Child; D006801:Humans; D007021:Hypospadias / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D007223:Infant; D008297:Male; D010413:Penis / Q000002:abnormalities / Q000187:drug effects; D013739:Testosterone / Q000031:analogs & derivatives* / Q000627:therapeutic use
D013739:Testosterone; C004648:testosterone enanthate
Unterstützende Testosteronbehandlung bei der operativen Korrektur von Hypospadien.