The elimination, distribution, and metabolism of 14C-toxaphene in the pregnant rat.
Pregnant Sprague-Dawley rats were orally administered 14C-toxaphene in olive oil on day 15 of pregnancy and housed in glass metabolism cages. Urine, feces, and tissues were collected and assayed for radioactivity. The elimination was similar to that in virgin females with the majority of activity excreted in the feces (38.4%; five days) and less in the urine (23.7%; five days). The fetuses contained the lowest levels of radioactivity of all tissues tested (28 ppb; five days) and fat contained the highest levels (7476 ppb; five days). A comparison of the activity in the fetuses with that in the dam's fat showed slight differences, indicating the presence of more polar compounds (perhaps metabolites).
D000818:Animals; D002250:Carbon Radioisotopes; D002855:Chromatography, Thin Layer; D005260:Female; D005333:Fetus / Q000032:analysis; D007306:Insecticides / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014112:Toxaphene / Q000378:metabolism*
D002250:Carbon Radioisotopes; D007306:Insecticides; D014112:Toxaphene