Effects of DDAVP, a vasopressin analog, on delayed matching behavior in the pigeon.
Five pigeons were tested in a delayed matching-to-sample task after receiving an acute injection of DDAVP (1-desamino-8-D-arginine), scopolamine or d-amphetamine. A feeding test also was used to document non-specific drug effects. Scopolamine produced a marked dose-related decrement in accuracy of matching, regardless of delay, indicating that scopolamine impairs both discrimination and short-term memory. Neither DDAVP nor d-amphetamine produced consistent changes in delayed matching. Thus, an experimental model of short-term memory with pigeons did not confirm the findings of others of a positive effect of DDAVP upon cognitive performance in humans.
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D003118:Color Perception / Q000187:drug effects; D010856:Columbidae; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology; D004193:Discrimination Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D012601:Scopolamine / Q000494:pharmacology
D001127:Arginine Vasopressin; D012601:Scopolamine; D003894:Deamino Arginine Vasopressin; D003913:Dextroamphetamine