The effect of clemastine and hydroxyzine on cutaneous histamine response in man.
Histamine-induced cutaneous wheals were measured in five healthy volunteers 2, 4, 8 and 24 hours after per os administration of a single dose of clemastine 1 mg and hydroxyzine 25 mg. Clemastine produced a mean wheal suppression of 9%, 18% and 6%, while hydroxyzine produced a mean wheal suppression of 49%, 73%, 82% and 77%. This experiment demonstrates the potent and long-lasting anti-H1 effect of hydroxyzine.
D000328:Adult; D002974:Clemastine / Q000627:therapeutic use*; D003876:Dermatitis, Atopic / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D006632:Histamine; D006801:Humans; D006919:Hydroxyzine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011759:Pyrrolidines / Q000627:therapeutic use*
D011759:Pyrrolidines; D006919:Hydroxyzine; D006632:Histamine; D002974:Clemastine