The pharmacokinetics and pharmacodynamics of bumetanide in normal subjects.
The pharmacokinetics and pharmacodynamics of bumetanide (1 mg) administered either orally or intravenously were studied in a group of normal subjects using high-pressure liquid chromatography. A two-compartment model adequately fitted the intravenous data. Renal clearance (85 ml min-1) contributed 65% to the total elimination of bumetanide irrespective of whether a model-dependent or model-independent method was used. Oral administration of bumetanide elicited a greater and a more prolonged pharmacological response than did intravenous bumetanide. An attempt is made to relate the pharmacokinetics of the drug to its pharmacodynamics.
D000284:Administration, Oral; D000328:Adult; D001834:Body Water / Q000378:metabolism; D002034:Bumetanide / Q000378:metabolism* / Q000494:pharmacology; D003404:Creatinine / Q000378:metabolism / Q000652:urine; D004232:Diuretics / Q000378:metabolism*; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D009318:Natriuresis / Q000187:drug effects; D011188:Potassium / Q000652:urine
D004232:Diuretics; D002034:Bumetanide; D003404:Creatinine; D011188:Potassium