Upg-2: a urinary pepsinogen variant located on chromosome 1 of the mouse.
Acrylamide gel electrophoresis of mouse urine distinguishes two groups of pepsinogens, the fast-migrating group A and the slow-migrating group B. Inbred mouse strains fall into two categories with respect to group B pepsinogens, one expressing a single-banded and the other a double-banded phenotype. This variation is controlled by a single locus, urinary pepsinogen-2 or Upg-2, which has at least two alleles, Upg-2s and Upg-2d. Typing of recombinant inbred strains suggests that the location of the Upg-2 locus is on chromosome 1, in the vicinity of loci coding for other peptidases, namely, Pep-2 and Rnr, and of the Acf-1 locus.
D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D004591:Electrophoresis, Polyacrylamide Gel; D008040:Genetic Linkage; D014644:Genetic Variation; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics* / Q000652:urine; D020116:Pepsinogen A; D010435:Pepsinogens
D010435:Pepsinogens; D020116:Pepsinogen A