title: Prospective comparison of the fluorescein-dilaurate test with the secretin-cholecystokinin test for pancreatic exocrine function.
abstract: In a prospective study of 60 patients undergoing investigation for possible exocrine pancreatic disease the fluorescein-dilaurate test was compared with the secretin-cholecystokinin (CCK) test. Forty one patients had a normal response to secretin-CCK, 14 patients had abnormal responses and in five patients the results were equivocal. Taking the secretin-CCK test as the diagnostic criterion, the fluorescein-dilaurate test had a sensitivity of 100% and a negative predictive value of 100%. There was a 54% false-positive rate. The fluorescein-dilaurate test is easy to perform and is a useful screening test for pancreatic exocrine insufficiency.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002766:Cholecystokinin; D005260:Female; D005452:Fluoresceins; D006801:Humans; D008297:Male; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000175:diagnosis; D010186:Pancreatic Function Tests / Q000379:methods*; D011446:Prospective Studies; D012633:Secretin
chemical_list: D005452:Fluoresceins; D012633:Secretin; D002766:Cholecystokinin; C034833:fluorescein dilaurate