title: Virulence of Bordetella bronchiseptica from pigs with or without atrophic rhinitis.
abstract: The virulence of 17 isolates of Bordetella bronchiseptica from 13 pig herds was compared by intranasal infection of gnotobiotic piglets and LD50 tests on mice. Of 59 piglets given 8.1-10-5 log 10 colony-forming units (cfu) of isolates from two herds with atrophic rhinitis (AR isolates) or isolates from six unaffected herds (non-AR isolates), 16 died of acute pneumonia; the survivors developed non-progressive turbinate hypoplasia and chronic pneumonia. Infection of 11 piglets with c. 3.0 log to cfu of three AR isolates or three non-AR isolates caused turbinate hypoplasia, but only slight pneumonia and no deaths. There were no significant differences between the virulence of AR and non-AR isolates in piglets. In LD50 tests in mice, there were no significant differences between the results from six AR isolates and six non-AR isolates, or from toxin prepared from two AR isolates and one non-AR isolates was fairly uniform, and that other factors must be responsible for the occurrence of progressive lesions of atrophic rhinitis in some but not all infected herds.
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000633:toxicity; D001884:Bordetella / Q000472:pathogenicity*; D001885:Bordetella Infections / Q000662:veterinary*; D007928:Lethal Dose 50; D051379:Mice; D009296:Nasal Cavity / Q000382:microbiology; D012222:Rhinitis, Atrophic / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology*; D014420:Turbinates / Q000473:pathology
chemical_list: D001427:Bacterial Toxins