Changes in plasma volume and protein concentration induced by cytochalasin E in the rat: a time-course study.
Cytochalasin E produced a reduction of plasma volume and protein concentration paralleled to biphasic accumulation of peritoneal fluid at 3.0 and 6.75 h after i.p. administration to rats. At the same time, there was an accumulation of fluid in the thoracic cavity following a disappearance of peritoneal fluid in the first peak. Neither a sublethal nor a lethal dose given i.v. induced a similar response. This indicates that such changes caused by cytochalasin E given i.p. may possibly be due to adjustment of the cardiovascular system.
D000818:Animals; D001202:Ascitic Fluid / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001798:Blood Proteins / Q000378:metabolism*; D003572:Cytochalasins / Q000494:pharmacology*; D005260:Female; D006400:Hematocrit; D009183:Mycotoxins / Q000494:pharmacology*; D010953:Plasma Volume / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D001798:Blood Proteins; D003572:Cytochalasins; D009183:Mycotoxins; C007215:cytochalasin E