[Effects on the process of DNA transcription in vitro of formaldehyde and the products of its reaction with amines].
When transcription of DNA treated with aminomethylol compounds (products of formaldehyde reaction with amines) was studied, aminomethylol produced a marked inhibition of the template activity of double-stranded DNA (up to 85%). Formaldehyde suppressed the transcription of native DNA as well, however, only when taken at concentrations exceeding those of the aminomethylol compounds 20-fold.
D000588:Amines / Q000494:pharmacology*; D000605:Amino Alcohols / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D004247:DNA; D004269:DNA, Bacterial; D005557:Formaldehyde / Q000494:pharmacology*; D007700:Kinetics; D013329:Structure-Activity Relationship; D013698:Templates, Genetic; D013950:Thymus Gland; D014158:Transcription, Genetic / Q000187:drug effects*
D000588:Amines; D000605:Amino Alcohols; D004269:DNA, Bacterial; D005557:Formaldehyde; D004247:DNA
Vliianie na protsessy transkriptsii DNK in vitro formal'degida i produktov ego vzaimodeĭstviia s aminami.