Effect of 5 alpha-reduced androgens on prolactin secretion.
The effects of a 6-day treatment with 2 mg/day of testosterone, dihydrotestosterone (DHT), 5 alpha-androstan-3 alpha, 17 beta-diol (3 alpha-diol) and 5 alpha-androstan-3 beta, 17 beta-diol (3 beta-diol) on serum prolactin levels have been evaluated in long-term castrated male and female rats. The steroids were administered either in the free alcohol or in the propionated form (mono and dipropionates for the 3 alpha- and 3 beta-diols). Practically no effect of any steroid was evident in the treated male animals. DHT and 3 alpha-diol inhibited prolactin secretion in the female animals, while testosterone and 3 beta-diol remained ineffective. The data suggest a possible role of 5 alpha-reduced compounds, DHT and 3 alpha-diol in the control of prolactin secretion in females.
D000728:Androgens / Q000494:pharmacology*; D015113:Androstane-3,17-diol / Q000494:pharmacology; D000818:Animals; D013196:Dihydrotestosterone / Q000494:pharmacology; D005260:Female; D008297:Male; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000728:Androgens; D013196:Dihydrotestosterone; D015113:Androstane-3,17-diol; D011388:Prolactin