Ionic and non-ionic contrast media interaction with anticoagulant drugs.
Normal and pathologic human plasmas were incubated with radiographic contrast media, heparin, Dextran-40 and saline. Renografin-60 produced a strong anticoagulant effect and the clotting times were significantly prolonged; the addition of heparin resulted in greatly elevated thrombin time. No such prolongation was noted with Dextran-40. P-297, ioxaglic and ioxithalamic acids also showed similar anticoagulant properties. When dogs were injected with contrast media and heparin, the overall anticoagulant effect lasted for more than 6 hours, while contrast media or heparin effect remained for a short period of time. Clinical significance of contrast media interactions with anticoagulant drugs is discussed.
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D003287:Contrast Media / Q000494:pharmacology*; D004285:Dogs; D004347:Drug Interactions; D005260:Female; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010314:Partial Thromboplastin Time; D014914:Whole Blood Coagulation Time
D000925:Anticoagulants; D003287:Contrast Media; D006493:Heparin