Effects of promethazine on hemorrhagic shock in the dog.
The effects of pre- and post-treatment with promethazine, an antihistamine, in hemorrhage-shocked dogs were investigated. Survival to 6 hours was enhanced in the dogs given (IM administration) the H1-receptor antagonist at 1 hour before hemorrhage was induced when compared with survivals of saline-treated control dogs (3 of 5 dogs vs 1 of 5 dogs). Furthermore, 4 of 5 dogs given (IV administration) promethazine at 30 minutes after the initial hemorrhage survived. Promethazine treatment by either route increased mean arterial pressure among surviving dogs throughout the 6-hour experimental period.
D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy* / Q000401:mortality; D004285:Dogs; D005260:Female; D007273:Injections, Intramuscular / Q000662:veterinary; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D011398:Promethazine / Q000008:administration & dosage / Q000627:therapeutic use*; D012771:Shock, Hemorrhagic / Q000188:drug therapy / Q000401:mortality / Q000662:veterinary*; D013997:Time Factors
D011398:Promethazine