[Experimental study of the intrauterine ototoxicity of dibekacin].
Previous works have demonstrated that mammals are more susceptible to aminoside ototoxicity during the period of auditory development. In order to test the intrauterine ototoxicity of dibekacin, an experiment was designated in pregnant guinea pigs intoxicated during the last three weeks of gestation (100, 60 and 30 mg/kg for 8 days). Newborn guinea pigs were tested electrophysiologically by recording cochlear potentials from the round window in response to filtered clicks of various frequency. No fetal ototoxicity due to dibekacin could be detected in the 36 animals tested. This study indicates that dibekacin has a very low ototoxic effect, even during the period of increased sensitivity to antibiotics. Comparatively, kanamycin has a major ototoxic effect when it is administrated at the same dosage during the same period of time.
D000818:Animals; D000831:Animals, Newborn; D003055:Cochlear Microphonic Potentials; D003982:Dibekacin / Q000009:adverse effects*; D005260:Female; D006168:Guinea Pigs; D007612:Kanamycin / Q000031:analogs & derivatives*; D007759:Labyrinth Diseases / Q000139:chemically induced* / Q000196:embryology; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*
D003982:Dibekacin; D007612:Kanamycin
Etude expérimentale de l'ototoxicité in utero de la dibékacine.