[Transport of calcium and distribution of calmodulin in the erythrocytes in primary arterial hypertension].
Calcium transport to inside-out vesicles and calmodulin erythrocytic distribution were examined in primary hypertension, using the isotope exchange method and phosphodiesterase activity measurement. No differences in total erythrocyte calmodulin content and its cytoplasmic and membrane concentrations were detected in either hypertensive patients, or rats with spontaneous hypertension. Differences in the rates of calcium transport through EGTA-treated membranes were only detectable in the presence of exogenous calmodulin. The erythrocytes of hypertensive patients showed a four-fold reduction in the maximum calcium transport rate increment under the effect of calmodulin, as compared to normotensive subjects. These differences are attributed to a possible disruption of calmodulin interaction with Mg, Ca-ATPase.
D000328:Adult; D000368:Aged; D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000097:blood*; D002135:Calcium-Binding Proteins / Q000097:blood*; D002147:Calmodulin / Q000097:blood*; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D051381:Rats; D011919:Rats, Inbred Strains
D002135:Calcium-Binding Proteins; D002147:Calmodulin; D002118:Calcium
Transport kal'tsiia i raspredelenie kal'modulina v éritrotsitakh pri pervichnoĭ arterial'noĭ gipertenzii.