[Muscle irritation study on T-1982].
The local irritation effect of T-1982 after the intramuscular injection into the musculus vastus lateralis was examined in rabbits. T-1982 was dissolved by the way of clinical use and was injected singly into the musculus vastus lateralis. Then the degree of muscular injury at the time of 2 days and 7 days after the injection was judged from muscle weight ratio, gross local observation and histological observation. The degree of muscular injury caused by T-1982 was compared with that of saline, 0.75% acetic acid and 6% acetic acid. On the degree of muscular injury of T-1982 was almost equal to that of 0.75% acetic acid, but milder than 6% acetic acid. From these, it was concluded that the local irritation effect of T-1982 was grade 3.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity; D002511:Cephalosporins / Q000633:toxicity*; D002513:Cephamycins / Q000008:administration & dosage / Q000633:toxicity*; D007273:Injections, Intramuscular; D008297:Male; D009132:Muscles / Q000033:anatomy & histology / Q000473:pathology; D009220:Myositis / Q000139:chemically induced; D009929:Organ Size; D011817:Rabbits
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002513:Cephamycins; C035978:cefbuperazone