[Selective inhibition of microcirculation in tumor tissue by manipulated blood pressure reduction].
It was shown on the DS-carcinosarcoma of rat that NAD-induced blood pressure reduction to 50% of the initial value is followed by a selective compression ischemia in the tumor tissue. In this period that can be prolonged to at least 10 min by infusion of NAD the microcirculation in the tumor tissue is almost completely inhibited. Determinations of the blood volume confirm the results obtained bei O. D. measurements. The significance of this finding and its eventual utilization (cancer therapy) are discussed.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D007700:Kinetics; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D009243:NAD / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000098:blood supply* / Q000503:physiopathology
D009243:NAD
Selektive Hemmung der Mikrozirkulation im Krebsgewebe bei manipulierter Blutdrucksenkung.