The plasma cation pattern in fever and sodium salicylate antipyresis.
The effect of sodium salicylate at a dose of 200 and 1000 mg/kg, per os, on body temperature and plasma cation pattern was investigated in healthy rabbits and those infected with 1 microgram/kg iv of lipopolysaccharide Escherichia coli (LPS). An increase in plasma Cu2+ and decrease in Fe2+ and Mg2+ concentration appeared to be the most important effect in LPS treated animals. Sodium salicylate in a dose-dependent manner attenuated the febrile response to LPS. Furthermore, this antipyretic antagonized the rise of Cu2+ concentration induced by pyrogen. Smaller increases of K+ and Mg2+ were observed during antipyresis than in the group of rabbits treated with sodium salicylate alone.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002412:Cations / Q000097:blood*; D005260:Female; D005334:Fever / Q000097:blood*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D011817:Rabbits; D012980:Sodium Salicylate / Q000494:pharmacology*; D013997:Time Factors
D002412:Cations; D008070:Lipopolysaccharides; D012980:Sodium Salicylate