Model system oxidations supporting the crystal growth model of ferritin iron uptake.
Fe2+ is oxidized and taken up by ferritin or ápoferritin in the presence of dioxygen. Iodate causes Fe2+ oxidation and uptake by ferritin, but not by apoferritin. Synthetic iron polymer facilitates Fe2+ oxidation by either dioxygen or iodate. Nitrilotriacetic acid or iminodiacetic acid facilitate oxidation of Fe2+ by oxygen but not by iodate. These results support the crystal growth model of ferritin iron uptake, with iron polymer serving as a model for the ferritin core and aminocarboxylic acids mimicking the metal-binding sites of apoferritin.
D001052:Apoferritins / Q000378:metabolism; D003460:Crystallization; D005293:Ferritins / Q000378:metabolism*; D007452:Iodates; D007501:Iron / Q000378:metabolism*; D007700:Kinetics; D008961:Models, Structural; D009571:Nitrilotriacetic Acid; D010084:Oxidation-Reduction
D007452:Iodates; D005293:Ferritins; D001052:Apoferritins; D007501:Iron; D009571:Nitrilotriacetic Acid