Time course of the effect of flunarizine on rabbit isolated vascular muscle.
Flunarizine inhibited KCl contractions of the rabbit aorta, mesenteric artery and portal vein progressively over 3-4 h. The rate of development of block was approximately linear on a logarithmic scale and was similar for equieffective concentrations (aorta = 2.1 microM, mesenteric artery and portal vein = 0.21 microM). It is concluded that flunarizine can discriminate between calcium ion channels opened during the spike and those opened during sustained depolarization.
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002936:Cinnarizine / Q000031:analogs & derivatives / Q000494:pharmacology*; D005444:Flunarizine; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010879:Piperazines / Q000494:pharmacology*; D011817:Rabbits
D002121:Calcium Channel Blockers; D010879:Piperazines; D002936:Cinnarizine; D005444:Flunarizine