The hydroperoxide-induced release of mitochondrial calcium occurs via a distinct pathway and leaves mitochondria intact.
The hydroperoxide-induced net release of Ca2+ from rat liver mitochondria is stimulated by the Ca2+ uptake inhibitor ruthenium red. At moderate Ca2+ loads the release takes place with preservation of a high mitochondrial membrane potential. During and after Ca2+ release mitochondria remain intact. The hydroperoxide-induced release of Ca2+ might therefore be of physiological relevance.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D007425:Intracellular Membranes / Q000187:drug effects / Q000502:physiology; D007700:Kinetics; D008564:Membrane Potentials / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010545:Peroxides / Q000494:pharmacology*; D051381:Rats; D020122:tert-Butylhydroperoxide
D010545:Peroxides; D020122:tert-Butylhydroperoxide; D002118:Calcium