Effect of alpha-monofluoromethyl histidine, an irreversible inhibitor of histidine decarboxylase, on gestation in mice.
Chronic administration of alpha-monofluoromethyl histidine, a specific inhibitor of histidine decarboxylase, to pregnant mice blocked histidine decarboxylase activity and markedly depleted histamine levels in 18-day-old foetuses and in newborn mice. Such treatment had no effect on implantation or embryonic development or parturition suggesting that de novo synthesis of histamine is not a significant factor in these processes in the mouse.
D000818:Animals; D001724:Birth Weight / Q000187:drug effects; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006632:Histamine / Q000378:metabolism; D006639:Histidine / Q000031:analogs & derivatives*; D006640:Histidine Decarboxylase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008762:Methylhistidines / Q000494:pharmacology*; D051379:Mice; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy
D008762:Methylhistidines; D006639:Histidine; C028309:alpha-fluoromethylhistidine; D006632:Histamine; D002262:Carboxy-Lyases; D006640:Histidine Decarboxylase