Degradation studies on sulphacetamide eye-drops. Part 2: Spectrophotometric evaluation of decomposition products of UV-irradiated solutions of sulphacetamide.
Multicomponent spectrophotometric assay methods have been used for quantitative determination of major photodecomposition products of sulphacetamide solutions. The reproducibility of the assay method lie within 4% of error. The hydrolysis of sulphacetamide to sulphanilamide and the oxidation of sulphanilamide to a blue product is a first-order reaction while the formation of azo dye from sulphanilamide is found to be a second-order reaction. A general scheme of photodegration pathways for sulphacetamide and sulphanilamide is presented.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D009883:Ophthalmic Solutions / Q000032:analysis; D010782:Photolysis; D013409:Sulfacetamide / Q000032:analysis* / Q000528:radiation effects; D014466:Ultraviolet Rays
D009883:Ophthalmic Solutions; D013409:Sulfacetamide