Effects of four restricted liquid diet regimens and one nonrestricted solid diet regimen on enzyme activities associated with hepatic drug metabolism.
Two different nutritionally adequate liquid diets containing either 18% protein, 47% carbohydrate and 35% lipid, or 18% protein, 12% carbohydrate and 70% lipid were given to rats once daily or in four divided doses for 3 weeks. The liquid diets decreased hepatic protein content and concentration and the activities of hepatic gamma-glutamyl transferase and NADPH cytochrome c reductase, compared to a zero time group fed chow and water. There were no important differences between the treatment groups. Aniline hydroxylase activity was also decreased by the liquid diets, but the high-lipid diet decreased the activity significantly less than the high-carbohydrate diet. Rats fed chow and water ad libitum for 3 weeks were less different from the zero time value than rats in any of the liquid diet groups. The effects of liquid diets may be important in alcohol research, where a high-carbohydrate liquid diet in restricted amounts is being widely used for feeding the control animals.
D000818:Animals; D001835:Body Weight; D004032:Diet; D004040:Dietary Carbohydrates / Q000494:pharmacology; D004041:Dietary Fats / Q000494:pharmacology; D005526:Food, Formulated; D008099:Liver / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D011506:Proteins; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases