[Retinal detachment and retraction. Effect of steroidal and nonsteroidal anti-inflammatory agents on the autoimmune reaction against the retina in idiopathic retinal detachment with signs of retraction].
The leukocyte adherence was employed to detect patients with auto-immunity against the retina, in three series of retinal detachments associated with peripheral vitreo-retinal retraction. The first serie of 14 patients received no medical treatment; the second serie of 19 patients was submitted an antiprostaglandins drug (tiaprofenic acid); the third serie of 16 patients received systemic corticoids. The leukocyte adherence test was performed before surgery and 10 days after surgery in all patients. It showed that auto-immunity against the retina after surgery was half as frequent in those patients submitted to anti-inflammatory drugs than in those patients who received no medical treatment. Moreover, the results of the present study suggest that: 1) Auto-immunity against the retina after surgery is twice as frequent in retinal detachments with associated massive vitreo-retinal retraction than in those which are surgical successes with good visual results (no macular pucker). 2) Auto-immunity against the retina 10 days after surgery is more frequent in those retinal detachments needing more than 20 cryo-applications than in those needing less than 20 cryo-applications.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007957:Leukocyte Adherence Inhibition Test; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011422:Propionates / Q000627:therapeutic use; D012160:Retina / Q000276:immunology* / Q000473:pathology; D012163:Retinal Detachment / Q000276:immunology* / Q000473:pathology / Q000601:surgery / Q000628:therapy
D000893:Anti-Inflammatory Agents; D001323:Autoantibodies; D005938:Glucocorticoids; D011422:Propionates; C021270:tiaprofenic acid
Décollement de rétine et rétraction rétinienne. Effet des anti-inflammatoires stéroïdiens et non stéroïdiens sur la réaction auto-immune contre la rétine dans les décollements de rétine idiopathiques avec signes de rétraction.