Interstrain variation of esterase-22, a new isozyme of the house mouse.
1. A new liver esterase in the house mouse, ES-22, is described, using different staining methods after dose electrophoretic separation on polyacrylamide gels. 2. Five different phenotypes, ES-22A to ES-22E, could be distinguished in various mouse strains. ES-22 is genetically closely linked to ES-6, ES-9 and ES-20 on chromosome 8, but its distribution among different strains appears to be independent from these isozymes. 3. ES-22 is clearly different from other chromosome 8-controlled esterases, with respect to its organ expression and its catalytic properties. 4. A gene locus Es-22 with five alleles is suggested. 5. It is proposed that the genes coding for the carboxylesterase isozyme system on chromosome 8 constitute a multigene family as defined by Hood et al. (1975).
D000375:Aging; D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D004950:Esterases / Q000235:genetics* / Q000378:metabolism; D005260:Female; D007527:Isoenzymes / Q000235:genetics* / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains / Q000378:metabolism*; D010641:Phenotype; D013045:Species Specificity; D014018:Tissue Distribution
D007527:Isoenzymes; D004950:Esterases