title: [Ultrastructure of hypophyseal adenomas induced by internal irradiation in female rats].
abstract: Following single administration of 75Se-methionine to female rats, adenomas of hypophysis were revealed in these, after some delayed periods of time. The tumors developed on the background of a high level of estradiole in the rat's blood. With the electron microscope these tumors were differentiated as prolactionomas. It has been shown that the increase in the number of prolactin-producing cells is due mainly to chromophobic cell differentiation, in addition to the stomatotrophocyte transformation under a long-term hyperestrogenization of the organism.
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000648:ultrastructure*; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000648:ultrastructure; D005260:Female; D007275:Injections, Intravenous; D009381:Neoplasms, Radiation-Induced / Q000378:metabolism / Q000648:ultrastructure*; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000648:ultrastructure*; D011388:Prolactin / Q000378:metabolism; D051381:Rats; D012645:Selenomethionine / Q000008:administration & dosage; D013997:Time Factors
chemical_list: D011388:Prolactin; D012645:Selenomethionine
vernacular_title: Ul'trastruktura adenom gipofiza, indutsirovannykh vnutrennim oblucheniem, u samok krys.