Lymphocyte activation by low doses of cyclosporin A.
Supernatants of human lymphocyte cultures incubated with cyclosporin A (CS-A) for 90 min reveal an inhibitory effect on the electrophoretic mobility of guinea-pig macrophages. This effect is distinctly demonstrable already at CS-A concentrations from 10-7 micrograms/ml on with a maximum at 10-3 micrograms/ml. An inhibitory action of CS-A on PHA-induced lymphocyte proliferation is detectable only beyond 10-2 micrograms/ml CS-A. The CS-A induced lymphokine is comparable to that stimulated by other ways (PHA, ConA).
D000818:Animals; D003524:Cyclosporins / Q000494:pharmacology*; D006168:Guinea Pigs; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008222:Lymphokines / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects
D003524:Cyclosporins; D008222:Lymphokines