title: Double enkephalins.
abstract: Basing on the conclusions drawn from the biological activities of previously synthesized enkephalin analogues, a new class of enkephalin analogues named double-enkephalins have been proposed, in which C-terminal amino acid residue is replaced by a second active fragment of enkephalin analogue connected by diamine bridge. Guinea-pig ileum test showed high biological activity of proposed analogues but depending on the size of diamine bridges.
mesh_terms: D000818:Animals; D001665:Binding Sites; D004745:Enkephalins / Q000138:chemical synthesis / Q000494:pharmacology*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D004745:Enkephalins