[Can silicon diffusion from silicone rubber catheters cause urethral stricture?].
Silicon-leakage out of alloplastic Silicon containing implants induces myofibroblast proliferation and constricting scar tissue. Therefore the possible Silicon-leakage out of Silicon rubber Foley-Catheters was of major interest. This cathaters were often used after internal urethrotomies of recurrent urethral strictures. Pieces of Silicon rubber Foley-Catheters of 18 F, 2 cm in length, were implanted subcutaneously and intraperitoneally in rats. Using Scanning electron microscopy and EDXA (energy dispersiv x-ray microanalysis) Silicon could not be identified in tissues around the implants 6 and 12 weeks after implantation. Therefore Silicon-leakage out of Silicon rubber Foley-Catheters is not responsible for recurrent urethral strictures.
D000818:Animals; D004058:Diffusion; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D012826:Silicone Elastomers / Q000009:adverse effects*; D014521:Urethra / Q000473:pathology; D014525:Urethral Stricture / Q000139:chemically induced* / Q000473:pathology; D014546:Urinary Catheterization / Q000009:adverse effects*
D012826:Silicone Elastomers
Kann eine Siliziumdiffusion aus Silikonkautschukkathetern Harnröhren-strikturen verursachen?