Toxicology of 85Kr: tissue distribution and retention in the rat.
Wistar rats were exposed to 85Kr gas atmospheres to determine saturation/desaturation kinetics in major tissues. Tissue partition coefficients [concentration 85Kr in tissue (muCi/g)/concentration of 85Kr in the atmosphere (muCi/cc)] were determined following equilibration with 85Kr gas. Tissue partition coefficients were highest for adrenals and fat; lowest for bone, heart and brain. Tissue partition coefficients for immature rats, 1-12 days of age, and for adults, were not significantly different. The highest concentrations of 85Kr were found in fatty tissues and in gas pockets in the intestinal lumen.
D000375:Aging; D000818:Animals; D001921:Brain / Q000378:metabolism; D005260:Female; D007413:Intestinal Mucosa / Q000378:metabolism; D007726:Krypton / Q000378:metabolism*; D008168:Lung / Q000378:metabolism; D008297:Male; D011829:Radiation Dosage; D011868:Radioisotopes / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D011868:Radioisotopes; D007726:Krypton