Effect of sulfur dioxide-sulfate exposure on rat respiratory tract clearance.
The effects of a 4 hour exposure to a model sulfur pollutant atmosphere on the clearance of inhaled insoluble tracer particles from the lungs of rats has been studied. The pollutant combination consisted of 5 ppm of sulfur dioxide gas and 1.5 mg/m3 of sulfate aerosol at 80-85% relative humidity. The exposure atmosphere was aged for 30 minutes upstream of the exposure chamber in an aging line in order to provide for gas/ particle interactions such as those occurring in industrial and environmental atmosphere. Results indicate that the sulfur pollutant atmosphere did not produce a statistically significant alteration in early (nasopharyngeal and tracheobronchial) or late (parenchymal) clearance rates such as those which have been identified in this laboratory following exposure to ozone-containing atmospheres.
D000336:Aerosols; D000393:Air Pollutants; D000818:Animals; D001273:Atmosphere Exposure Chambers; D004781:Environmental Exposure; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012137:Respiratory System / Q000378:metabolism*; D013431:Sulfates / Q000378:metabolism*; D013458:Sulfur Dioxide / Q000378:metabolism*
D000336:Aerosols; D000393:Air Pollutants; D013431:Sulfates; D013458:Sulfur Dioxide