Effects of Freund's complete adjuvant and ovalbumin sensitization on the pharmacological reactivity of isolated guinea-pig trachea.
Tracheal strips were obtained from guinea-pigs injected with ovalbumin alone, ovalbumin incorporated into Freund's complete adjuvant (FCA), or FCA alone. There was no difference (P greater than 0.05) in amplitude of ovalbumin-induced contractile responses in tracheas from antigen sensitized and antigen + FCA sensitized animals. Although partial contraction of the muscle with carbachol (ED50) was unaffected by the various treatments, the relaxation responses to isoprenaline, histamine (H2-stimulation) and theophylline were impaired in the group receiving the ovalbumin + FCA sensitization regimen. These results are suggestive of an abnormal response associated with a defective cAMP system in this group.
D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D005620:Freund's Adjuvant / Q000276:immunology*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D007114:Immunization; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D010047:Ovalbumin / Q000276:immunology*; D013806:Theophylline / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects / Q000276:immunology*
D006632:Histamine; D002217:Carbachol; D010047:Ovalbumin; D005620:Freund's Adjuvant; D013806:Theophylline; D007545:Isoproterenol