[Studies on the correlation of toxoplasma antibody between mothers and their infants in toxoplasmosis in pregnancy].
The author examined immunoglobulin and toxoplasma antibody titer using a routine serologic test in 55 pregnant women with positive antibody titer and their infants (including one twin). After evaluation of the immunological correlationship between mothers and infants, the toxoplasma antibody titer half life in infants and its decay curve were derived from IgG toxoplasma antibody titer in infants. The IgG toxoplasma antibody titer at delivery well correlated with the titer transition in infants thereafter, and the infants were divided into the following three groups for comparison with mothers' titer at delivery. Group A (mothers' titer = infants' titer), group B (mothers' titer greater than infants' titer), group C (mothers' titer less than infants' titer). The antibody titer in group A and C decreased to negative at one year of age, the value in group B, however, at 6 months after delivery. Toxoplasma antibody titer (X) and antibody half life (T) from delivery to one month, from one month to 3 months and from 3 months to 6 months respectively, were derived as follows: (formula; see text) When the antibody titer of an infant is higher than the decay curve, toxoplasma infection is strongly indicated.
D000906:Antibodies / Q000032:analysis*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology*; D014122:Toxoplasma / Q000276:immunology*; D014123:Toxoplasmosis / Q000276:immunology*; D014125:Toxoplasmosis, Congenital / Q000276:immunology
D000906:Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M