title: Circadian rhythmicity and sleep: effects of aging in laboratory animals.
abstract: This literature review of research on age-related differences in sleep and rhythmic phenomena in laboratory animals covers three general areas: (1) age-related differences in biorhythms in general; (2) age-related differences in sleep patterns as assessed by psychophysiological measures; and (3) neurobiological correlates of biorhythms and sleep, including consideration of possible morphological, chemical, and endocrine bases of age-related defects in animal models. It is concluded that systematic research bridging these areas is lacking although several promising areas have been explored.
mesh_terms: D000375:Aging; D000818:Animals; D002415:Cats / Q000502:physiology*; D002940:Circadian Rhythm; D006728:Hormones / Q000502:physiology; D008125:Locus Coeruleus / Q000502:physiology; D008550:Melatonin / Q000502:physiology; D051379:Mice / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology; D010870:Pineal Gland / Q000502:physiology; D011149:Pons / Q000502:physiology; D051381:Rats / Q000502:physiology*; D012160:Retina / Q000502:physiology; D012701:Serotonin / Q000502:physiology; D012890:Sleep / Q000502:physiology*; D013493:Suprachiasmatic Nucleus / Q000502:physiology
chemical_list: D006728:Hormones; D012701:Serotonin; D008550:Melatonin; D009638:Norepinephrine