Effects of 5-thioglucose on feeding and glycemia in the hamster.
Adult male hamsters (Mesocricetus auratus) did not increase their food consumption in a 5 hr feeding test when injected with doses of 5-thioglucose (5-TG) ranging up to 500 mg/kg, although insulin (50 U/kg) did produce hyperphagia. However, 5-TG did produce significant increases in both plasma glucose and plasma free fatty acids. Thus the hamster's failure to eat in response to 5-TG administration cannot be ascribed to a simple failure to detect the metabolic consequences of 5-TG. Hypotheses are proposed which may account not only for the hamster's failure to eat in response to 5-TG, but also for other well-established peculiarities in the feeding behavior of hamsters.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005947:Glucose / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008647:Mesocricetus
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; C003002:5-thio-D-glucose; D005947:Glucose