title: Dna synthesis in the urinary-tract epithelium of the rat induced by laparotomy and by intraperitoneal injection of distilled water, physiological saline and lycopodium spores.
abstract: The tritiated thymidine labelling index (LI) of the epithelium of the ureters and urinary bladder of young male Wistar rats is substantially increased 18 h after a simple laparotomy incision. A similar highly significant increase (P less than 0.001) has been observed after a single i.p. injection of various materials, including (a) distilled water, (b) 0.5% glycogen in physiological saline, and (c) 1% suspension of lycopodium spores in physiological saline. In each instance an aseptic inflammatory response develops in the peritoneal cavity. Reasons are given supporting the concept that a mitogen is produced from a constituent of the inflammatory exudate in the peritoneal cavity and that the factor reaches the affected epithelium by direct diffusion.
mesh_terms: D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D004848:Epithelium / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007813:Laparotomy; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000008:administration & dosage; D013171:Spores, Bacterial; D013936:Thymidine / Q000378:metabolism; D014513:Ureter / Q000378:metabolism*; D001743:Urinary Bladder / Q000378:metabolism*; D014867:Water / Q000494:pharmacology
chemical_list: D014867:Water; D012965:Sodium Chloride; D004247:DNA; D013936:Thymidine