Aqueous immune complexes in immunogenic uveitis.
A primary immunogenic uveitis was produced in rabbits by the intravitreal injection of bovine plasma albumin or ovalbumin. A secondary or recurrent uveitis was induced by intravenous injection of the specific soluble antigen several months after the cessation of primary inflammation. Aqueous antigen-antibody complexes were studied at times of maximal clinical response in both primary and recurrent forms during resolution of primary immunogenic uveitis, and in a nonspecific protein extravasation induced by aqueous paracentesis. Immune complexes could be demonstrated only during times of clinically evident inflammation in immunogenic uveitis. The results indicate the importance of antigen-antibody complex formation in the pathogenesis of this form of experimental ocular inflammatory disease.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis*; D001082:Aqueous Humor / Q000276:immunology*; D004195:Disease Models, Animal; D007111:Immunity, Cellular; D011817:Rabbits; D014605:Uveitis / Q000209:etiology / Q000276:immunology*
D000936:Antigen-Antibody Complex