Effect of Liv-52 on carbon tetrachloride-induced changes in hepatic microsomal drug-metabolizing enzymes of the rat.
The effects of the hepatotonic Liv-52 on carbon tetrachloride (CCl4)-induced changes in the activities of the microsomal enzymes, aniline hydroxylase, p-aminopyrine N-demethylase and aryl hydrocarbon hydroxylase (AHH), have been investigated. Treatment with Liv-52 (before or after CCl4 administration) markedly decreased, the CCl4-mediated reduction in aniline hydrochloride and p-aminopyrine N-demethylase activities, although the decrease in AHH activity could not be prevented. Kinetic studies showed that the effect of Liv-52 was not due to an alteration in the Km values of the enzymes. The possible mechanism by which Liv-52 moderated the CCl4-induced changes in the microsomal drug-metabolizing enzymes is discussed.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology* / Q000473:pathology; D004338:Drug Combinations / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D004338:Drug Combinations; D010936:Plant Extracts; C002614:Liv 52; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases