title: Patent ductus arteriosus in premature infants: a review of current management.
abstract: Problems related to the ductus arteriosus confront the pediatrician more than any other isolated cardiac defect. Due to increased awareness of the problems of prematurity, the reported frequency of patent ductus arteriosus increased threefold between 1970 and 1975. Aggressive therapy directed toward closure of the ductus is indicated within the first week of life in the very immature infant. Pharmacologic closure of the PDA with indomethacin is effective about half the time.
mesh_terms: D004374:Ductus Arteriosus, Patent / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000628:therapy*; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000628:therapy*
chemical_list: D007213:Indomethacin