Proximal motor neuropathy in the BB-Wistar rat.
Proximal motor neuropathy is a well-recognized neuropathic complication in human diabetes mellitus, due to microvasculopathic changes. Spontaneously diabetic BB-Wistar rats maintained at a moderate severity of diabetes developed structural proximal motor neuropathy after long-standing diabetes. This was caused by multiple infarcts in the spinal ventral roots. Endoneurial vessels showed occlusions by platelet aggregates and unstriated fibrin, indicative of a hypercoagulability.
D000818:Animals; D003925:Diabetic Angiopathies / Q000473:pathology; D003929:Diabetic Neuropathies / Q000473:pathology*; D007238:Infarction / Q000473:pathology; D008297:Male; D009046:Motor Neurons / Q000648:ultrastructure*; D009468:Neuromuscular Diseases / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013126:Spinal Nerve Roots / Q000098:blood supply / Q000648:ultrastructure