Involvement of cytochrome b-245 in the respiratory burst of human neutrophils.
The cytochrome b 245 of human neutrophils was reduced when the neutrophils under anaerobic conditions were stimulated by serum-treated zymosan, immune complexes, or phorbol myristate acetate. Reintroduction of oxygen rapidly reoxidized the cytochrome; azide was without effect on any of these reactions. This indicates that cytochrome b 245 participates in the respiratory burst of neutrophils.
D000328:Adult; D000693:Anaerobiosis; D000936:Antigen-Antibody Complex; D001386:Azides / Q000494:pharmacology; D003573:Cytochrome b Group / Q000378:metabolism*; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D015054:Zymosan / Q000494:pharmacology
D000936:Antigen-Antibody Complex; D001386:Azides; D003573:Cytochrome b Group; D015054:Zymosan; D013755:Tetradecanoylphorbol Acetate