Regulation of 3-hydroxybutyrate formation and secretion of very-low-density-lipoprotein triacylglycerol by perfused livers from fed and starved rats.
Acetoacetate was the sole ketone body formed when livers from starved rats were perfused with minimal concentrations of non-esterified fatty acid. Absence of 3-hydroxybutyrate was related to a low substrate potential, which caused a more oxidized redox state and a decreased [ATP]/[ADP] ratio. Only under conditions of comparable non-esterified fatty acid uptake was lipoprotein triacylglycerol production inversely related to ketogenesis.
D020155:3-Hydroxybutyric Acid; D000090:Acetoacetates; D000818:Animals; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006885:Hydroxybutyrates / Q000096:biosynthesis*; D066298:In Vitro Techniques; D007651:Keto Acids / Q000378:metabolism; D007657:Ketone Bodies / Q000096:biosynthesis; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation; D014280:Triglycerides / Q000378:metabolism*
D000090:Acetoacetates; D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D007651:Keto Acids; D007657:Ketone Bodies; D008079:Lipoproteins, VLDL; D014280:Triglycerides; C030106:very low density lipoprotein triglyceride; C016635:acetoacetic acid; D020155:3-Hydroxybutyric Acid