[Stability of cyclodrin hydrochloride. 3: Stability of cyclodrin hydrochloride as a substance and in ophthalmologic solutions. 51: Contributions to problems concerning the use of plastic receptacles for liquid pharmaceuticals].
The authors deal with the stability of cyclodrin hydrochloride. A reference sample of solid cyclodrin hydrochloride stored for four and a half years showed 0.4-0.6% degradation. A storage stability of five years is considered justifiable. In eye-drops the stability of this active agent is determined by the pH value. Unbuffered eye-drops (optimized formula) are considerably more stable than the buffered solutions hitherto used. Unbuffered eye-drops contained in glass bottles as well as in plastic bottles should be stable for 2-3 years.
D004349:Drug Packaging; D004355:Drug Stability; D005898:Glass; D006863:Hydrogen-Ion Concentration; D009883:Ophthalmic Solutions / Q000032:analysis; D010648:Phenylacetates / Q000032:analysis*; D010969:Plastics; D013997:Time Factors
D009883:Ophthalmic Solutions; D010648:Phenylacetates; D010969:Plastics; C002864:cyclodrine
Beitrag zur Stabilität des Cyclodrinhydrochlorids. Teil 3: Stabilität des Cyclodrinhydrochlorids als Substanz und in ophthalmologischen Lösungen. 51. Mitteilung: Beiträge zur Problematik des Einsatzes von Kunststoffbehältern für flüssige Arzneizubereitungen.