In vitro and in vivo studies of the molecular pathogenesis of n-Hexane neuropathy.
In vivo intoxication of rats with 2,5-hexanedione and 3,4-dimethyl-2,5-hexanedione, which results in axonal swellings filled with neurofilaments, has been combined with in vitro exposure of proteins and model amines to the gamma-diketones in attempts to explain the molecular pathogenesis of n-hexane neuropathy and related neurofilament neuropathies. The heretofore untested gamma-diketone, 3,4-dimethyl-2,5-hexanedione is proposed as a "missing link" between beta, beta'-iminodipropionitrile, which produces proximal aggregates of neurofilaments, and 2,5-hexanedione, acrylamide, and carbon disulfide, which result in neurofilament-filled swellings in the distal axon.
D000818:Animals; D001369:Axons / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004591:Electrophoresis, Polyacrylamide Gel; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism; D006586:Hexanes / Q000633:toxicity*; D009422:Nervous System Diseases / Q000139:chemically induced*; D009474:Neurons / Q000187:drug effects; D011758:Pyrroles / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013439:Sulfhydryl Reagents / Q000494:pharmacology
D006586:Hexanes; D011758:Pyrroles; D013439:Sulfhydryl Reagents; C026385:n-hexane; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases