title: [Sensitivity of 1041 strains of bacteria obtained from an intensive care unit with regard to aminoglycosides].
abstract: Antibiotic treatment of infections due to opportunistic organisms often involves an aminoglycoside/bêta lactamine combination. In order to help in the selection of the aminoglycoside used, a statistical study was made of 1041 strains of organisms obtained from an intensive care unit to 4 aminoglycosides: gentamicin, amikacin, tobramycin and dibekacin. These included Gram negative bacilli (enterobacteria, pseudomonas, acinetobacter) and staphylococci. The study showed amikacin to be the most suitable aminoglycoside for prescription in an infection threatening the vital prognosis in the short term and where the organism has not been identified. In non-threatening infections when the organism has not been identified, gentamicin, tobramycin or dibekacin should be used in preference to amikacin. For any type of infection, once the organism has been identified, amikacin should only be used if it is the only effective agent. When the organism is equally sensitive to gentamicin, tobramycin and dibekacin the choice of drug should take into account the known potential toxicities of each drug.
mesh_terms: D000583:Amikacin / Q000494:pharmacology; D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D003982:Dibekacin / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D007362:Intensive Care Units; D008826:Microbial Sensitivity Tests; D014031:Tobramycin / Q000494:pharmacology
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D003982:Dibekacin; D000583:Amikacin; D014031:Tobramycin
vernacular_title: Sensibilité de 1041 souches de germes provenant d'un service de réanimation à l'égard des aminosides.