[Effect of cortisol, malnutrition and orchiectomy on the concentration of proteins and nucleic acids in rat liver].
Cortisol action on some hepatic parameters related to protein synthesis has been studied in normal and orchidectomized male rats. Since cortisol causes an intake reduction, pair-feeding runs were conducted to achieve results of the hormone action unbiased by the effects derived from the intake restriction. Administration of cortisol in doses of 0.8 mg/100 g of body weight/day to rats from weaning up to 30 days produced a significant increase in DNA and cell liver numbers and a decrease in proteins/DNA, cellular weight and RNA/DNA in unorchidectomized rats. While in orchidectomized rats these parameters do not vary. The intake restriction that cortisol provokes, produced a significant reduction in protein content, proteins/DNA, cellular weight and RNA/DNA. An increase in DNA and cell numbers in unorchidectomized rats, while in orchidectomized rats produced a reduction greater in DNA and cell numbers and an increase in RNA/DNA. Orchidectomy in control rats determined a decrease in protein liver content, DNA, proteins/DNA, cell numbers and cellular weight.
D000818:Animals; D002369:Castration; D006854:Hydrocortisone / Q000494:pharmacology*; D008099:Liver / Q000032:analysis* / Q000166:cytology / Q000473:pathology; D008297:Male; D009696:Nucleic Acids / Q000032:analysis*; D009748:Nutrition Disorders / Q000378:metabolism*; D009929:Organ Size; D011506:Proteins / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D009696:Nucleic Acids; D011506:Proteins; D006854:Hydrocortisone
Efectos del cortisol, malnutrición y orquidectomía en la concentración de proteínas y ácidos nucleicos en hígado de rata.