[Relations between disorders of lipid metabolism and the development of myocardial damage after stimulation of affective areas of the hypothalamus].
An experimental study in 24 rabbits showed the stimulation of ventromedian hypothalamic nuclei to increase the myocardial content of free fatty acids and lysophospholipids, and reduce that of phosphatidyl choline, phosphatidyl ethanolamine and cardiolipin. A direct correlation was established between increased myocardial content of free fatty acids, lysophosphatidyl choline, lysophosphatidyl ethanolamine and the accumulation of 99mTc-pyrophosphate. Enhanced catabolism of membrane phospholipids was shown to contribute considerably to the accumulation of 99mTc-pyrophosphate and the development of myocardial neurogenic lesions.
D000818:Animals; D004558:Electric Stimulation; D004644:Emotions / Q000502:physiology; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D007026:Hypothalamic Area, Lateral / Q000502:physiology*; D050356:Lipid Metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D011817:Rabbits; D011877:Radionuclide Imaging; D014280:Triglycerides / Q000378:metabolism; D014697:Ventromedial Hypothalamic Nucleus / Q000502:physiology*
D010743:Phospholipids; D014280:Triglycerides
O sviazi mezhdu narusheniem metabolizma lipidov i vozniknoveniem povrezhdeniia miokarda pri stimulatsii émotsiogennykh zon gipotalamusa.