[Erythrocyte changes from the administration of excess doses of retinoids].
It has been shown that all-trans-methylretinoate, 13-cis-methyl retinoate and retinoid C15 administered intraperitoneally in the form of 0.05% solutions in excess doses reduce the red cell count, hemoglobin content, and osmotic resistance of red cells in C57Bl/6 mice. Administration of 13-cis-methylretinoate and retinoid C15 resulted in the increase of the number of cells uncapable to stain with paraldehyde fuchsin. Anemia induced by all-trans-methylretinoate in AKR mice was accompanied by erythropoiesis enhancement in the bone marrow.
D000740:Anemia / Q000139:chemically induced; D000818:Animals; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000187:drug effects*; D006454:Hemoglobins / Q000032:analysis; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D013997:Time Factors; D014212:Tretinoin / Q000008:administration & dosage / Q000031:analogs & derivatives; D014801:Vitamin A / Q000008:administration & dosage / Q000031:analogs & derivatives*
D006454:Hemoglobins; D014801:Vitamin A; D014212:Tretinoin; C026296:methyl retinoate
Izmeneniia éritrotsitov pri vvedenii izbytochnykh doz retinoidov.