The effect of bezafibrate and clofibrate on microsomal ACAT and lysosomal cholesterol ester hydrolase activity in the cholesterol-fed rabbit aorta.
Bezafibrate markedly reduced the activity of fatty acyl CoA:cholesterol acyltransferase (ACAT) in the microsomal fraction of aortas from cholesterol-fed rabbits, while clofibrate was a less potent inhibitor. The activity of lysosomal cholesterol ester hydrolase (LCEH) was not significantly affected by either agent, indicating that inhibition of ACAT rather than stimulation of LCEH is a mechanism whereby these agents may decrease the cholesterol ester content of atherosclerotic aorta.
D000217:Acyltransferases / Q000037:antagonists & inhibitors*; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000201:enzymology*; D001629:Bezafibrate; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D002994:Clofibrate / Q000031:analogs & derivatives* / Q000494:pharmacology*; D002995:Clofibric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008247:Lysosomes / Q000201:enzymology*; D011817:Rabbits; D012044:Regression Analysis; D002787:Sterol Esterase / Q000097:blood*; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*
D000960:Hypolipidemic Agents; D002995:Clofibric Acid; D000217:Acyltransferases; D002785:Sterol O-Acyltransferase; D002265:Carboxylic Ester Hydrolases; D002787:Sterol Esterase; D002994:Clofibrate; D001629:Bezafibrate