Inhibition of gastric acid secretion by intestinal and parenteral administration of a mixture of L-amino acids in the Atlantic cod, Gadus morhua.
The effect on basal gastric acid secretion in the cod of a mixture of L-amino acids (AA) was studied. Acid secretion was measured during a 5 h treatment period when the AA was administered intestinally, i.m. or i.v., and plasma alpha-amino nitrogen following the treatment period. Acid secretion was inhibited, the depression related to the plasma level of AA but unrelated to the administration route. It is suggested that acid secretion is inhibited by absorbed AA acting from the blood side, without involvement of an intestinal mechanism.
D000596:Amino Acids / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D005260:Female; D005399:Fishes / Q000502:physiology*; D005744:Gastric Acid / Q000378:metabolism*; D007263:Infusions, Parenteral; D007267:Injections; D007273:Injections, Intramuscular; D007422:Intestines; D008297:Male
D000596:Amino Acids