title: [Combination therapy with indomethacin and sulindac in chronic polyarthritis].
abstract: A study of 20 patients with rheumatoid arthritis was undertaken, in which the patients were treated with the non-steroidal combination of Sulindac in the morning and Indometacin in the evening. The clinical efficacy of this combination was good to excellent in 19 patients (95%) during the 4 week treatment period. One patient discontinued treatment for reason of intolerance of Indometacin-suppositories. 3 more patients showed only minor side effects. Blood chemistry, performed before and after the study, did not show any significant changes, except for the blood uric acid, which was significantly reduced after 4 weeks. This is remarkable, because after monotherapy with Indometacin or Sulindac respectively an uricosuric effect of these substances is not reported.
mesh_terms: D000328:Adult; D000368:Aged; D001168:Arthritis / Q000097:blood / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007192:Indenes / Q000008:administration & dosage*; D007213:Indomethacin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D013467:Sulindac / Q000008:administration & dosage*
chemical_list: D007192:Indenes; D013467:Sulindac; D007213:Indomethacin
vernacular_title: Kombinationsbehandlung mit Indometacin und Sulindac bei chronischer Polyarthritis.