[Implantable repository adrenaline tablets for long-term studies on rats].
Implantable coated Eudragit matrix tablets containing adrenaline in various concentrations should overcome the problem of additional handling stress during long term infusions. The efficiency of those tablets was tested in vitro, as well as in vivo using labeled adrenaline. Both in vitro and in vivo testing yielded satisfactorily output rates up to 20 h whereby the liver and serum content of 14C-fragments served as an additional prove for the postulated mode of action. Good correlation has been found between the mentioned out-put rates and adrenaline serum levels (measured according to Da Prada).
D000818:Animals; D004343:Drug Implants; D004837:Epinephrine / Q000008:administration & dosage* / Q000097:blood; D008099:Liver / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004343:Drug Implants; D004837:Epinephrine
Implantierbare Adrenalin-retard-Tabletten zur Langzeituntersuchung in Ratten.