Stimulation of prostaglandin E production by rat synovium induced by intraarticular injection of measles virus.
Measles virus was injected into the joints of rats. Prostaglandin E in organ cultures of synovial tissue removed from injected joints was evaluated. A 9-fold increase of prostaglandin E concentration was found in cultures of synovial membranes from joints injected with measles virus as compared to controls. Histologic examination revealed inflammation in the synovial membranes of joints injected with virus. We suggest that prostaglandin E may mediate joint inflammation induced by measles virus.
D000818:Animals; D001170:Arthritis, Infectious / Q000378:metabolism* / Q000473:pathology; D007270:Injections, Intra-Articular; D008297:Male; D008457:Measles / Q000378:metabolism* / Q000473:pathology; D008458:Measles Vaccine / Q000008:administration & dosage*; D011458:Prostaglandins E / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013583:Synovial Membrane / Q000378:metabolism*; D013585:Synovitis / Q000473:pathology
D008458:Measles Vaccine; D011458:Prostaglandins E