Effect of L-thyroxine on metabolism in Japanese quails (Cotournix cotournix japonica)--II. Activity of GOT and GPT in liver, LDH and ICDH in heart and kidney after multiple injections of L-thyroxine.
1. Quails hatched from eggs incubated at physiological temperature (37.5 degrees C--normal quails) and elevated (39.3 degrees C--warm quails) were injected with L-thyroxine (T4) at the dose of 600 micrograms/kg of body weight, every 48 hr for 17 days. 2. Twenty-four hours after the last injection activity of aspartate aminotransferase (GOT), alanine aminotransferase (GPT) was determined in liver homogenates and lactate dehydrogenase and isocitrate dehydrogenase in homogenates of heart and kidney. 3. Significant increase of the activity of GPT in liver homogenates was observed in normal and warm quails up to 252.9 and 186.8% of control, respectively). 4. The activity of aspartate aminotransferase increased significantly in liver homogenates of T4-treated normal quails, while such changes in the warm quails were not observed. 5. Activities of lactate dehydrogenase (LDH) and isocitrate dehydrogenase (ICDH) in heart and kidney homogenates in both T4-treated groups of birds did not change.
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D003370:Coturnix / Q000378:metabolism*; D006358:Hot Temperature; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D007668:Kidney / Q000201:enzymology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*; D011784:Quail / Q000378:metabolism*; D013974:Thyroxine / Q000494:pharmacology*
D007770:L-Lactate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D013974:Thyroxine