The influence of age, sex and genotype on the subcellular distribution of hepatic aldehyde dehydrogenase activity in the mouse.
1. The influence of age on hepatic aldehyde dehydrogenase (AlDH) was studied in both sexes of two selectively bred lines of mice (Mus musculus). 2. Whole liver AlDH activity increased from the 60-day-old level linearly up to 200 days of age. The enzyme activity of the females remained at the 200-day-old level, but in males. AlDH continued to increase up to 400 days of age. Males had higher AlDH activity than females. 3. The AlDH activities of 3 subcellular fractions: cytosol, mitochondria and microsomes also increased with age, but were more dependent on sex and genotype than was the whole liver activity. 4. It was concluded that AlDH activity increases with age in mouse liver but it was influenced greatly by sex, genotype and subcellular fraction studied.
D000367:Age Factors; D000444:Aldehyde Dehydrogenase; D000445:Aldehyde Oxidoreductases / Q000378:metabolism*; D000818:Animals; D005260:Female; D005838:Genotype; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D012737:Sex Factors; D013347:Subcellular Fractions / Q000201:enzymology; D014018:Tissue Distribution
D000445:Aldehyde Oxidoreductases; D000444:Aldehyde Dehydrogenase