Cell-mediated immunity in normal pregnancy and pre-eclampsia.
The in vitro responses of maternal lymphocytes to phytohaemagglutinin (PHA), concanavalin A (Con A) and purified protein derivative of tuberculin (PPD) were determined in uncomplicated and pre-eclamptic pregnancies and nongravid female controls. PHA, Con A and PPD responses were significantly lower in both pregnant groups compared to nongravid controls. No difference was observed in lymphocyte reactivity between women with pre-eclampsia or uncomplicated pregnancy. Both pregnant groups exhibited normal numbers of circulating T and B lymphocytes. The number of active E rosette-forming cells was significantly higher in peripheral blood of pre-eclamptic patients.
D000293:Adolescent; D000328:Adult; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008214:Lymphocytes; D010835:Phytohemagglutinins / Q000494:pharmacology; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy; D012397:Rosette Formation; D014373:Tuberculin / Q000276:immunology
D010835:Phytohemagglutinins; D014373:Tuberculin; D003208:Concanavalin A