Effects of naftidrofuryl on cerebral hemodynamics, metabolism and function after a retracted ischaemia.
Unilateral microemboli were formed in the brains of Long Evans rats by means of an intracarotid injection of microspheres (50 mu). This embolization resulted in a decrease in blood flow, severe cerebral oedema and a modification of glucose uptake. Furthermore, these microemboli affected a conditioned avoidance response. Naftidrofuryl enabled a better recovery of the processes involved in the expression of acquisition. This has been related to a decrease in the development of oedema on one side and to a better glucose uptake on the other. These data demonstrated that naftidrofuryl influences the sequelae of rapidly regressive ischaemia.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002545:Brain Ischemia / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D003847:Deoxyglucose / Q000378:metabolism; D005260:Female; D005663:Furans / Q000494:pharmacology*; D008297:Male; D009257:Nafronyl / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D005663:Furans; D009257:Nafronyl; D003847:Deoxyglucose