Pharmacological evacuation of the stomach with metoclopramide.
Children admitted for emergency operations because of trauma run a high risk of chemical aspiration pneumonitis syndrome. Fifty-eight children admitted for closed reduction of fractures and suturing of wounds were studied in a double-blind manner in order to see if metoclopramide could be of value in decreasing the risk of aspiration during anaesthesia. Metoclopramide given before anaesthesia proved to enhance gastric evacuation and could thus be of value in these situations. In addition, the study showed that the time from last oral intake until start of anaesthesia is of less importance then the type of trauma in prolonging the gastric emptying time and thus increasing the risk of vomiting and aspiration of vomitus into the lungs during anaesthesia.
D000758:Anesthesia / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D050723:Fractures, Bone / Q000601:surgery; D005745:Gastric Acidity Determination; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use*; D011015:Pneumonia, Aspiration / Q000517:prevention & control*; D011229:Preanesthetic Medication
D008787:Metoclopramide