The effects of pyronin on sprouting and regeneration of mouse motor nerves.
Administration to mice of a 0.1% solution of pyronin G in their drinking water caused an acceleration both of axonal sprouting from nodes of Ranvier in partly denervated gluteus maximus muscles, and of motor nerve regeneration following a crush to the soleus nerve. Sprouting from soleus motor nerve terminals in response to botulinum toxin-induced paralysis was, however, unaffected. Removal of degenerating axons following nerve section was also accelerated by pyronin treatment. Pyronin is therefore likely to act upon the process of Wallerian degeneration, rather than upon intact motor nerves directly.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001369:Axons / Q000187:drug effects*; D001905:Botulinum Toxins / Q000494:pharmacology; D005260:Female; D006614:Hindlimb / Q000294:innervation; D009046:Motor Neurons / Q000187:drug effects*; D009115:Muridae; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000294:innervation; D009409:Nerve Crush; D009410:Nerve Degeneration / Q000187:drug effects; D009416:Nerve Regeneration / Q000187:drug effects*; D009431:Neural Conduction / Q000187:drug effects; D011754:Pyronine / Q000494:pharmacology*; D011901:Ranvier's Nodes / Q000187:drug effects; D014966:Xanthenes / Q000494:pharmacology*
D014966:Xanthenes; D001905:Botulinum Toxins; D000109:Acetylcholine; D011754:Pyronine