title: [Tridoxin toxicity and tolerance in agricultural animals].
abstract: It was found that LD50 of tridoxin (sulfadoxin-trimetoprim-5 + 1--State Economic Corporation Pharmachim) at i/m application to albino mica was 950 mg/kg, and of borgal (Hochst)--920 mg/kg. At oral application these values were 2650 and 2660 mg/kg, respectively. LD50 of tridoxin at i/m application to albino rats was 1075 mg/kg, and of borgal--1320 mg/kg; orally, these values were 3000 and 3260 mg/kg, respectively. When introduced into the crop of week-old broilers the LD50 values of fridoxin and borgal were 942 and 1670 mg/kg, respectively. The oral administration of tridoxin with the feed in 3 to 5 times higher amounts than was the therapeutic muscular dose to albino rats in the course of 30 days did not lead to clinical, clinical-and-biochemical, and histopathologic changes. The tolerance of tridoxin at a single i/m injection of a 5- times higher dose than the therapeutic one (0.075 g/kg) in the case of calves was good, with the exception of transient pain at the time of injection and shortly after that and the slight, transient slowing down of forestomach movements. The injection of amounts 3 and 5 times as high as the doses for pigs, sheep, and weaned lambs was tolerated well. The application to sheep was found to be more painful than in the case of calves and pigs.
mesh_terms: D000818:Animals; D002417:Cattle; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004361:Drug Tolerance; D007928:Lethal Dose 50; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D012756:Sheep; D013413:Sulfadoxine / Q000633:toxicity*; D013424:Sulfanilamides / Q000633:toxicity*; D013552:Swine; D013997:Time Factors; D014295:Trimethoprim / Q000633:toxicity*
chemical_list: D004338:Drug Combinations; D013424:Sulfanilamides; D013413:Sulfadoxine; D014295:Trimethoprim
vernacular_title: Izsledvane vŭrkhu toksichnostta i ponosimostta ot selskostopanskite zhivotni na tridoksina.