title: [Effects of intravenous infusion of amikacin. Intraperitoneal administration to rats before and in the early stage of pregnancy. Segment 1].
abstract: Fertility study on amikacin sulfate (AMK) was carried out in Wistar rats. AMK was administered intraperitoneally at the doses of 0, 25, 100 mg/kg/day and 200 mg/kg/day in males for 60 days prior to mating and mating period and in females for 14 days prior to mating, mating period and day 0-7 of gestation. The drug induced no significant changes or signs in parent animals, except that soft feces was occasionally found at the 100 mg/kg/day and 200 mg/kg/day and the impairment in kidneys was recognized only at the 200 mg/kg/day. There were no adverse effects on mating, fertility or reproduction indices in males and females. And there were no evidences of teratogenic or embryotoxic effects in at any doses of AMK.
mesh_terms: D000583:Amikacin / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005333:Fetus / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007612:Kanamycin / Q000031:analogs & derivatives*; D007668:Kidney / Q000473:pathology; D008297:Male; D011247:Pregnancy; D051381:Rats
chemical_list: D007612:Kanamycin; D000583:Amikacin