Inhibitory effect of cytochalasin E on galactose absorption in the mouse in vitro.
The inhibitory effect of cytochalasin E on galactose absorption in everted sacs of mouse jejunum was studied. Cytochalasin B had highest potency on the inhibition of galactose absorption when it was added in the mucosal solution followed by cytochalasins E, A, C and D respectively. Cytochalasin E at a concentration as low as 2.5 micrograms/ml could inhibit galactose absorption by 17.1% within 60 min incubation and its maximum inhibition was obtained at a concentration of 10.0 micrograms/ml. At this concentration, it inhibited both Na+-dependent and independent galactose absorption. Our results in the present study and previously reported indicate that cytochalasin E inhibits the active intestinal absorption of galactose as well as glucose in the mouse.
D000818:Animals; D003572:Cytochalasins / Q000633:toxicity*; D005260:Female; D005690:Galactose / Q000378:metabolism*; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000378:metabolism; D051379:Mice; D009183:Mycotoxins / Q000633:toxicity*; D012964:Sodium / Q000494:pharmacology
D003572:Cytochalasins; D009183:Mycotoxins; C007215:cytochalasin E; D012964:Sodium; D005690:Galactose