Reactivity of the central nervous system in the disseminated intravascular coagulation in rats.
The reactivity of the central nervous system in the disseminated intravascular coagulation was studied. In this state the action of pentylenetetrazol and thiopental were decreased. Also shortening of tonic phase of electric convulsions was observed. No changes were noted in the contents of noradrenaline and serotonin, whereas slight increase in dopamine level in some regions of brain was found. It seems that observed effects are connected with other mechanisms than interaction with central mediators.
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D001921:Brain / Q000503:physiopathology*; D001923:Brain Chemistry / Q000187:drug effects; D004211:Disseminated Intravascular Coagulation / Q000503:physiopathology*; D005340:Fibrinogen / Q000378:metabolism; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology; D010976:Platelet Count; D011517:Prothrombin Time; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced
D001679:Biogenic Amines; D005340:Fibrinogen; D010433:Pentylenetetrazole