Glutathione S-transferase activities in placentas from smoking and non-smoking women.
1. Microsomal mono-oxygenase activity toward 7-ethoxyresoryfin, and cytosolic glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene were determined in 53 placentas obtained at delivery from smoking and non-smoking women. 2. Whereas mono-oxygenase activity was clearly stimulated in placentas from women who smoked, no parallel enhancement of glutathione S-transferase activity was evident. 3. This disparity in response could result in imbalance among placental detoxication systems following exposure to certain compounds.
D019363:Cytochrome P-450 CYP1A1; D003600:Cytosol / Q000201:enzymology; D005260:Female; D005982:Glutathione Transferase / Q000302:isolation & purification*; D006801:Humans; D008861:Microsomes / Q000201:enzymology; D010088:Oxidoreductases / Q000302:isolation & purification; D010920:Placenta / Q000201:enzymology*; D011247:Pregnancy; D012907:Smoking
D010088:Oxidoreductases; D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase