Bioadhesive and histotoxic properties of ethyl-2-cyanoacrylate.
Ethyl-2-cyanoacrylate was applied to the cortex of rabbits to evaluate its bioadhesive and histotoxic behavior. The animals were killed at 4 or 10 days. Half of the animals were pretreated with dexamethasone. Our results indicate that the application of ethyl-2-cyanoacrylate to brain tissue produced severe superficial cortical necrosis but not bioadhesion. Pretreatment with steroids did not provide a significant protective effect.
D000268:Adhesiveness; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000473:pathology; D055598:Chemical Phenomena; D002621:Chemistry; D003487:Cyanoacrylates / Q000633:toxicity*; D003907:Dexamethasone / Q000494:pharmacology; D009336:Necrosis; D011817:Rabbits
D003487:Cyanoacrylates; C029054:ethyl 2-cyanoacrylate; D003907:Dexamethasone