title: [Anomalous relationships between oocyte growth and the proliferative activity of the follicular epithelium in the ovaries of LT/Sv strain mutant mice].
abstract: A comparison of the number of follicular epithelium cells and its proliferative activity with the oocyte diameter upon normal (ICR mice) and abnormal (LT/Sv mice) oogenesis was carried out. Two populations of monolayered follicles were found in the LT/Sv mice. The population of normal follicles providing for reproductive function is characterized by a distinct correlation between the follicle size, number of DNA-synthesizing follicular cells and oocyte diameter. The group of abnormal follicles contains large oocytes the growth of which is ahead of the development of granulosa cells. The number of DNA-synthesizing cells of monolayered follicular epithelium is 6 times less than in the normal follicles. 96% of parthenogenetically cleaving eggs were found in such abnormal monolayered follicles as well, the number of DNA-synthesizing cells being 14 to 17 times less than that in the normal follicles. Possible mechanism of this phenomenon are discussed.
mesh_terms: D000818:Animals; D002455:Cell Division; D004247:DNA / Q000096:biosynthesis; D004847:Epithelial Cells; D005260:Female; D006107:Granulosa Cells / Q000166:cytology; D051379:Mice; D008813:Mice, Inbred ICR; D008817:Mice, Mutant Strains / Q000502:physiology*; D009865:Oocytes / Q000254:growth & development*; D006080:Ovarian Follicle / Q000166:cytology*; D010063:Ovum / Q000254:growth & development*; D010312:Parthenogenesis
chemical_list: D004247:DNA
vernacular_title: Anomal'nye vzaimootnosheniia mezhdu rostom ootsitov i proliferativnoĭ aktivnost'iu follikuliarnogo épiteliia v iaichnikakh mysheĭ linii LT/Sv.