[Triamterene and renal calculi].
The authors report the detailed analysis of 4 calculi containing triamterene observed between 1979 and 1981. The composition of drug layers is almost the same in the 4 calculi and shows a mixture of triamterene (estimated at 35% of iatrogenic components) and 7 metabolites among them p-hydroxy-triamterene (5-10%) and mainly p-hydroxytriamterene estersulfate (40-55%). The authors hypothesize a metabolic or physicochemical relation between triamterene and uric acid which are frequently associated in these calculi that represent 0.4% of all lithiasis. An estimated 150 to 200 calculi with triamterene are probably eliminated though not detected every year in France. The interest of a fine analysis of calculi by appropriate physical methods, such as infrared spectrometry, is emphasized.
D000328:Adult; D000368:Aged; D002855:Chromatography, Thin Layer; D006801:Humans; D007669:Kidney Calculi / Q000139:chemically induced* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013055:Spectrophotometry, Infrared; D014223:Triamterene / Q000009:adverse effects* / Q000032:analysis
D014223:Triamterene
Triamtérène et lithiases rénales.