Lack of suppression of increased circulating prolactin by 2-hydroxyestrone.
To study the effect of 2-hydroxyestrone (2-OHE1) on circulating prolactin (PRL) in a hyperprolactinaemic state, seven anovulatory women with hyperprolactinaemia were given a 2-OHE1 infusion at a rate of 80 microgram/h for 3 h following a control infusion. Plasma samples for PRL determination were obtained at 30-minute intervals for 6h. No changes in PRL levels were observed during the 2-OHE1 infusion as compared with the control period. It was concluded under conditions of the present experiment that 2-OHE1 does not suppress circulating PRL in hyperprolactinaemic anovulatory women.
D000328:Adult; D000858:Anovulation / Q000097:blood* / Q000188:drug therapy; D004970:Estrone / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D006894:Hydroxyestrones / Q000494:pharmacology* / Q000627:therapeutic use; D011388:Prolactin / Q000097:blood / Q000378:metabolism*
D006894:Hydroxyestrones; D004970:Estrone; D011388:Prolactin; C024980:2-hydroxyestrone