title: Renal metabolism of corticosteroid hormones.
abstract: IK and STF from male and female rats have been used to study in vitro the renal metabolism of B. in male rat tissue four lipid soluble metabolites (I-IV) have been found, I + II being more polar and III + IV being less polar than B. I and II have been identified as 11-dehydro-20-hydroxy-B and 20-hydroxy-B. The structure of III and IV remains to be determined. Renal tissue from female rats produced predominantly III indicating sexual variations of steroid metabolism in kidneys.--The literature has been reviewed which documents that the kidneys in addition to B metabolize A, cortisol, progesterone and other corticosteroids.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000096:biosynthesis / Q000378:metabolism*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008297:Male; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
chemical_list: D000305:Adrenal Cortex Hormones