The pathologic effect of ureteral ligation, with clinical implications.
Inadvertent, ureteral ligation is a frequent occurrence with pelvic surgery. We determined the effect of the ureteral ligation of varying lengths of time in an animal model in order to provide a rational basis for the clinical management of such injuries in humans. In the rat, simple deligation of a ureter that has been ligated for as long as 24 hours results in complete resolution of the injury with no gross or microscopic evidence of the trauma. After 48 and 72 hours of ligation, hydroureter was apparent.
D000818:Animals; D003250:Constriction; D006801:Humans; D007431:Intraoperative Complications; D008297:Male; D009130:Muscle, Smooth / Q000502:physiology; D009336:Necrosis; D051381:Rats; D012038:Regeneration; D013997:Time Factors; D014513:Ureter / Q000293:injuries / Q000473:pathology* / Q000502:physiology