Studies on the pulmonary capillary permeability after induced microembolism.
Pulmonary microembolization was induced by infusion of thrombin during inhibition of the fibrinolytic system. After embolization cardiac output decreased, pulmonary vascular resistance and pulmonary arterial pressure increased. There was a transient decrease in PaO2. Immediately after embolization there was an increased permeability indicated by tremendous increase in lymph flow with a constant lymph/plasma protein ratio. The lymph/plasma ratio for hemoglobin and for FITC-Dextran (mw 150 000) also increased indicating leakage of large molecules. The increased permeability was accompanied by a significant increase in extra-vascular lung-water as measured both with the thermal conductivity and the dry/wet weight method.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001834:Body Water; D002199:Capillary Permeability / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D005260:Female; D008168:Lung / Q000502:physiology*; D008196:Lymph / Q000187:drug effects; D008297:Male; D010313:Partial Pressure; D011652:Pulmonary Circulation / Q000187:drug effects; D011655:Pulmonary Embolism / Q000503:physiopathology*; D012119:Respiration / Q000187:drug effects; D013917:Thrombin / Q000494:pharmacology; D014655:Vascular Resistance / Q000187:drug effects
D013917:Thrombin