Pharmacokinetic evaluation of norendimide in rats.
Norendimide, the endo-isomer of the new psychoactive compound noreximide, was studied in rats upon I.V., P.O., and I.P. administration, and the pharmacokinetic parameters were determined from the concentration-time data. The one-compartment model was most appropriate for curve-fitting of all data. The elimination half-life is approximately 11 hours, and hence about 30% longer than that of the parent compound. The volume of distribution is about 85% of the body weight. Upon P.O. and I.P. administration the fraction of drug absorbed is 80% and 94%, respectively. A comparison with the previously reported pharmacokinetic data on noreximide indicates that both compounds, the parent drug and the analog, are completely absorbed and show some first-pass effect.
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D009636:Norbornanes / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism
D009636:Norbornanes; C032550:noreximide