title: [Melanogenesis, an expression of the differentiation of cancer cells in culture].
abstract: In B 16 mouse melanoma in culture, differentiated cells actively synthesize melanin. They are analysed by cytological and cytochemical methods. When cultured for long periods (several months), melanogenesis is expressed according to a cyclic way, even when maintained in a culture medium of constant composition and without adding any chemical agent eventually able to influence this phenomenon. This spontaneous cyclic activity is analysed and an explanation is given as an hypothesis.
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D006801:Humans; D008543:Melanins / Q000096:biosynthesis*; D008545:Melanoma / Q000503:physiopathology* / Q000648:ultrastructure; D051379:Mice; D008810:Mice, Inbred C57BL; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009374:Neoplasms, Experimental / Q000503:physiopathology / Q000648:ultrastructure
chemical_list: D008543:Melanins
vernacular_title: La mélanogénèse, expression de la différenciation de cellules cancéreuses en culture.