A generalized allergic reaction with acute interstitial nephritis following trimethoprim-sulfamethoxazole use.
A severe generalized multisystem allergic reaction occurred in a 16-month-old infant following the use of trimethoprim-sulfamethoxazole. Acute interstitial nephritis developed three weeks following the onset of this reaction and resolved after three months. This is the first description of this renal toxicity with TMP-SMX in a child.
D058186:Acute Kidney Injury / Q000139:chemically induced; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology*; D007223:Infant; D009395:Nephritis, Interstitial; D010031:Otitis / Q000188:drug therapy; D013420:Sulfamethoxazole / Q000009:adverse effects*; D014295:Trimethoprim / Q000009:adverse effects*
D014295:Trimethoprim; D013420:Sulfamethoxazole