[Effectiveness of heparin in patients with acute myocardial infarction].
Clinical pattern and complications of the disease were studied in 62 heparin-treated patients with large-focal myocardial infarction as compared to a control group of 59 patients treated with a polarizing mixture of glucose, insulin, potassium, analgetics and tranquilizers. The changes of the necrotic area and lesion were assessed on the basis of precardiac charting. The results obtained were correlated to the data on central hemodynamics, heart contractility and pumping function, gaseous exchange and acid-base balance. Heparin-treated patients showed a smaller rate of fatal outcomes, although primary ventricular fibrillation and heart failure prevailed in the mortality pattern in both groups. Heparin treatment improved central hemodynamics, contractility and pumping function of the heart, and gaseous exchange, while prestress decreased simultaneously, which is the optimum effect for patients with acute myocardial infarction. Precardiac charting data showed heparin treatment to be associated with a more rapid reduction in the depth of the ischemic lesion. The advantages of continuous intravenous heparin infusion are demonstrated.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics / Q000187:drug effects; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D010100:Oxygen / Q000097:blood
D006493:Heparin; D010100:Oxygen
Ob effektivnosti geparina u bol'nykh ostrym infarktom miokarda.