Carbohydrate patterns of endoscopic mucosal biopsies in cancer of the stomach and chronic gastritis.
The monosaccharide composition of the soluble glycoproteins of endoscopic gastric biopsies was studied with gas-liquid chromatography in patients with carcinoma of the stomach and in patients with chronic gastritis (controls). The analyses showed (1) that monosaccharide patterns were similar in the antrum and corpus of patients with chronic gastritis, (2) that the mannose content relative to the galactose content was increased in the tumor as compared with the antrum of the same stomach (p less than 0.05) and with the antrum (p less than 0.05) and corpus (p less than 0.02) of the control stomachs, and (3) that the N-acetylgalactosamine and N-acetylglucosamine content tended to be decreased in the tumor area as compared with the antrum and corpus of control stomachs. The changes in the histologically tumor-free part of the corpus of the cancer stomachs tended to be similar in direction to those in the tumor itself.
D000116:Acetylgalactosamine / Q000378:metabolism; D000117:Acetylglucosamine / Q000378:metabolism; D000328:Adult; D000368:Aged; D001706:Biopsy; D002908:Chronic Disease; D005260:Female; D005690:Galactose / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D005756:Gastritis / Q000378:metabolism*; D006801:Humans; D008297:Male; D008358:Mannose / Q000378:metabolism; D008875:Middle Aged; D009005:Monosaccharides / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism*
D009005:Monosaccharides; D000116:Acetylgalactosamine; D008358:Mannose; D000117:Acetylglucosamine; D005690:Galactose