Liver-protective actions of desoxypodophyllotoxin and its analogs.
Effects on CCl(4)-induced liver lesion in mice and on D-galactosamine-induced liver lesion in rats of desoxypodophyllotoxin (1) and its analogs, podophyllotoxin (2), podophyllotoxon (3), beta-peltatin (4), alpha-peltatin (5), 4'-demethylpodophyllotoxin (6) and picropodophyllin (7), were investigated. 1 and 7 in CCl(4)-induced liver lesion and 1,4,5, and 6 in D-galactosamine-induced liver lesion have shown marked protective actions. These results suggest that these analogs have liver-protective actions in general and the substituents at C-4 in ring C, C-5 in ring B and C-4' in ring E, and the configuration at C-2 in ring C are important for the revelation of the activity.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002252:Carbon Tetrachloride Poisoning / Q000150:complications; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal; D005688:Galactosamine / Q000494:pharmacology; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D004365:Drugs, Chinese Herbal; C014451:deoxypodophyllotoxin; D005688:Galactosamine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D011034:Podophyllotoxin