[Protective effect of vinpocetine on experimental brain ischemia].
The protective effect of vinpocetine on experimental brain ischemia was studied in stroke-prone spontaneously hypertensive rats (SHRSP) with bilateral carotid artery occlusion (BCAO) and in Wistar-Kyoto rats (WKY) subjected to BCAO and hemorrhage (1% of body weight). In SHRSP with BCAO, intraperitoneal (i.p.) injection of vinpocetine (1 mg/kg) 10 min before BCAO significantly prolonged the time required for the onset of ischemic seizure from 65 +/- 13 min (mean +/- SEM) to 117 +/- 19 min. In WKY with BCAO and hemorrhage, vinpocetine (5 mg/kg, i.p.) reduced the lactate level in the cerebral cortex from 11.6 +/- 2.7 mmol/g to 5.9 +/- 1.2 mmol/g and elevated the concentration of ATP from 2.05 +/- 0.09 mmol/g to 2.25 +/- 0.03 mmol/g. These results suggest a protective effect of vinpocetine against brain ischemia.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002545:Brain Ischemia / Q000517:prevention & control*; D002540:Cerebral Cortex / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*; D014748:Vinca Alkaloids / Q000008:administration & dosage / Q000494:pharmacology*
D007773:Lactates; D014665:Vasodilator Agents; D014748:Vinca Alkaloids; D019344:Lactic Acid; C013983:vinpocetine; D000255:Adenosine Triphosphate