title: Acetylcholinesterase (AchE) activity of lymphocytes in chronic lymphoid leukemia (CLL).
abstract: The specific AchE (EC 3.1.1.7) activity of lymphocytes from the peripheral blood of normal donors was determined. On Leukopak filter the isolated T lymphocytes showed activity, whereas in stepwise Percoll gradient, population TLD displayed enzyme activity. The THD and B cells were inactive. [Szelényi J. G., Bartha E. & Hollán S. R. (1982) Br. J. Haemat. 50, 241]. A mixed cell population derived from CLL patients had significantly lower enzyme activity than normal. With the progress of B-cell proliferation AchE activity decreased in parallel with the number of T cells. The sp. act. of TLD population isolated from CLL patients was the same as that of normal donors whereas their B cells were inactive.
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood / Q000201:enzymology*; D007958:Leukocyte Count; D008214:Lymphocytes / Q000201:enzymology*
chemical_list: D000110:Acetylcholinesterase