Decrease in the activity of hepatic microsomal drug-metabolizing enzymes in tumor-bearing nude mice.
The activities of hepatic microsomal drug-metabolizing enzymes in nude mice (BALB/c-nu/nu) bearing tumors of human or nude mouse origin were studied. The content of cytochrome P-450 and the activities of cyclophosphamide oxidase, benzo[a]pyrene hydroxylase, aniline hydroxylase and benzphetamine N-demethylase were markedly decreased in tumor-bearing nude mice in accordance with previous observations in tumor-bearing rats and mice. These results indicate that decreases in the activities of hepatic microsomal drug-metabolizing enzymes are not the consequence of an immunoreactive process or cachexia.
D000818:Animals; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008862:Microsomes, Liver / Q000201:enzymology*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000201:enzymology*; D010088:Oxidoreductases / Q000378:metabolism*
D010088:Oxidoreductases