The effect of oral contraceptives on coagulation and fibrinolytic parameters in the Chinese--a prospective study.
Thirty-two Chinese and 7 Caucasians were studied prospectively for 12 months for the effects of oral contraceptives (OC) on certain coagulation and fibrinolytic parameters. In both ethnic groups there was an increase in alpha 1 antitrypsin level. There was no significant change in antithrombin III concentration measured either by radioimmunoassay (At-III-RIA) or chromogenic assay (anti Xa-chromogenic) in the Chinese, but a significant decrease in anti Xa-chromogenic at 7 months and At-III-RIA at 12 months in the Caucasians. Also, alpha 2 plasmin inhibitor (alpha 2 PI) levels were unchanged in the Chinese but a significant increase occurred in the Caucasians at 12 months. Enhanced fibrinolytic response to venous occlusion was demonstrated in the Chinese at 12 months but not in the Caucasians.
D000328:Adult; D000990:Antithrombin III / Q000378:metabolism; D001777:Blood Coagulation / Q000187:drug effects*; D002681:China; D004997:Ethinyl Estradiol / Q000008:administration & dosage*; D005006:Ethnicity; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D009644:Norgestrel / Q000008:administration & dosage*; D000979:alpha-2-Antiplasmin / Q000378:metabolism
D000979:alpha-2-Antiplasmin; D009644:Norgestrel; D004997:Ethinyl Estradiol; D000990:Antithrombin III