[Harmful interactions of amiodarone and class I anti-arrhythmia agents].
Six patients treated with a combination of amiodarone and class I antiarrhythmic agents for a minor arrhythmia developed atypical ventricular tachycardia "en torsades de pointe". All patients had QT-interval prolongation in the ECG. Combined administration of quinidine and amiodarone in a normal volunteer resulted in an increase in plasma quinidine concentration and in QT prolongation, thus confirming the clinical observation of a clinically relevant interaction between the two drugs.
D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000008:administration & dosage / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D001572:Benzofurans / Q000009:adverse effects*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011802:Quinidine / Q000008:administration & dosage / Q000009:adverse effects; D013610:Tachycardia / Q000139:chemically induced* / Q000209:etiology
D000889:Anti-Arrhythmia Agents; D001572:Benzofurans; D011802:Quinidine; D000638:Amiodarone
Gefährliche Interaktionen zwischen Amiodaron und Antiarrhythmika der Klasse I.