title: [Liver damage caused by drugs].
abstract: Drug injury of the liver presents as I. functional disorder without jaundice; 2. predominant cholostatic disease; 3. predominant hepatitic disease; 4. a combination of 2 und 3.--A predictable dose related direct toxic injury can be differentiated from an unpredictable dose independent indirect injury mostly of the hypersensitivity type. Special varieties are severe fatty liver, peliosis, Budd-Chiari-Syndrome, liver tumors and granulomas. The diagnosis can be proven by reexposition or better--by the in vitro lymphocyte stimulation test. --There is no specific treatment apart from stopping the responsible drug. Prognosis is good but in some cases a chronic course develops presenting as chronic aggressive hepatitis or cirrhosis.
mesh_terms: D006502:Budd-Chiari Syndrome / Q000139:chemically induced; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000139:chemically induced; D008107:Liver Diseases / Q000628:therapy; D008297:Male
vernacular_title: Leberschädigung durch Arzneimittel.