[Lipid electrophoresis in the alcoholic. Features and usefulness in the diagnosis of various degrees of alcoholic liver diseases].
Reference is made to the importance of assessing serum lipoproteins by conventional agarose gel electrophoresis in the preliminary diagnosis of the degree of severity of a liver disease. A comparison is made between lipidogram changes in 48 alcoholic patients with the liver histologies following needle biopsy according to Menghini. The conclusion is drawn that in acute and chronic alcoholic liver disease there is a characteristic lipidogram profile, marked by a double "camel's hump" in the bands due to predominance of the beta and prebeta-lipoprotein fractions. This, in turn, is related to the liver steatosis observed bioptically. In macro and micronodular cirrhosis, however, examination of the electrophoretic lipid fractions is frequently unhelpful. Attention is drawn to the appearance of the alpha fraction as a presumably pointer to the condition in question. It is felt that this conventional, simple evaluation of lipoproteins is a valuable diagnostic test in assessing the seriousness of alcoholic liver disease.
D000328:Adult; D000437:Alcoholism / Q000097:blood*; D001569:Benzodiazepines / Q000627:therapeutic use; D001707:Biopsy, Needle; D004587:Electrophoresis, Agar Gel; D006801:Humans; D008055:Lipids / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008099:Liver / Q000473:pathology; D008108:Liver Diseases, Alcoholic / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged
D008055:Lipids; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D001569:Benzodiazepines
L'elettroforesi lipidica nell'etilista. Aspetti ed utilità nella diagnostica dei vari gradi dell'epatopatia alcoolica.