[On the polymorphism of barbiturates in powders and tablets. 6: Properties and behaviour of a spray-dried barbital preparation].
The manufacture of a spray-dried barbital preparation is described, the properties, tabletting behaviour and release of which were studied in comparison to the initial substance. Spray-drying led to a compression-resistant mixture of amorphous and crystalline particles. As most of these particles have a spherical shape, the tablets obtained from this mixture were of great compactness, which inhibited the penetration of the medium and, consequently, delayed the release of the drug, too.
D001462:Barbital / Q000032:analysis*; D001463:Barbiturates / Q000032:analysis*; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D010316:Particle Size; D011208:Powders / Q000032:analysis; D013607:Tablets / Q000032:analysis; D013816:Thermodynamics
D001463:Barbiturates; D011208:Powders; D013607:Tablets; D001462:Barbital
Zur Polymorphie der Barbiturate in Pulvern und Tabletten. 6. Mitteilung: Eigenschaften und Verhalten eines sprühgetrockneten Produktes von Barbital.