[The intra-arterial infusion. II. Its use in the treatment of septic gangrene].
The local toxicity of Cefazolin was evaluated for the arterial endothelium. 37 patients with septic gangrena were treated by intraarterial infusions of standardized Cefazolin infusions into the arteries of the involved legs. In the average 11.6 infusions were applied for one leg. The bacteriology of the infected gangrenous legs is discussed as well as the sensitivity of antibiotics of the germs found. A progression of the gangrena could be prevented in 78% of the cases, only minor surgical measures, such as borderline amputations or plastic interventions were necessary. No side effects due to the local application of the drug were observed. The intraarterial continuous infusion of broad band antibiotics for septic gangrena is recommended.
D000818:Animals; D001018:Aortic Diseases / Q000150:complications; D001157:Arterial Occlusive Diseases / Q000150:complications; D001424:Bacterial Infections / Q000188:drug therapy*; D002437:Cefazolin / Q000008:administration & dosage*; D002481:Cellulitis / Q000188:drug therapy; D004727:Endothelium / Q000187:drug effects; D005260:Female; D005734:Gangrene; D006801:Humans; D007261:Infusions, Intra-Arterial; D007871:Leg Ulcer / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy; D051381:Rats; D013530:Surgical Wound Infection / Q000517:prevention & control
D002437:Cefazolin
Die intraarterielle Infusion. II. Ihre Anwendung bei der Behandlung der septischen Gangrän.