[Gangliosides of neural and extraneural tissues of various species of mammals].
The ganglioside patterns of the forebrain, cerebellum and brain stem from horse, donkey, mule and goat have been determined by thin-layer chromatography. GM1, GD1a, GD1b and GT1b are the four major brain gangliosides. N-acetylneuraminic acid as the predominant sialic acid (congruent to 97%) and traces of N-glycolyneuraminic acid were found. The four above mentioned major gangliosides were also found in the forebrain, cerebellum and brain stem of adult rats. This pattern is not modified in rats under stress situation (at 4 degrees C for 3 months). In other extraneural organs from rats such as liver and kidney the patterns differ from those of the neural organs. Pig spleen lymphocyte gangliosides were studied by thin-layer chromatography. Their patterns show remarkable differences in comparison to those of neural organs. These gangliosides were also separated by DEAE Sephadex chromatography into two peaks, I and II. Peak I contains mainly monosialogangliosides and peak II contains disialogangliosides. No trisialogangliosides were practically detected in the material. Sheep platelets contain GM3 as predominant ganglioside.
D000818:Animals; D001188:Artiodactyla / Q000378:metabolism; D001923:Brain Chemistry; D002855:Chromatography, Thin Layer; D005732:Gangliosides / Q000032:analysis* / Q000302:isolation & purification; D006736:Horses / Q000378:metabolism; D051381:Rats / Q000378:metabolism; D011919:Rats, Inbred Strains / Q000378:metabolism; D013045:Species Specificity; D014018:Tissue Distribution
D005732:Gangliosides
Estudios sobre gangliósidos de tejidos neurales y extraneurales de varias especies de mamíferos.