[Nicergoline and steal effect in favor of zones of hypoperfusion in cerebral ischemic accidents].
Hemispheric and regional variations of cerebral blood flow (CBF) were studied with the Xenon inhalation technique on 19 patients suffering from cerebral infarcts before and at the end of a 10 mg 'alpha-blocking' Nicergoline perfusion. CBF dynamic images and calculations were performed with a gamma computerized camera. No significant hemispheric CBF modification has been noted after Nicergoline perfusion (30.2 +/- 4.5 ml/min/100 g before perfusion and 31 +/- 5.6 ml/min/100 g at the end of perfusion) but, at the end of perfusion, we noticed a CBF increase on the more ischemic areas (25.7 +/- 5.6 ml/min/100 g before and 29.9 +/- 6.8 ml/min/100 g after). This variation depends on the patients (from +67% to -22%). The more ischemic areas are those with the more important CBF increase. This 'inverse steel effect' is comparable to the effect described by other authors for Vincamine or Piracetam.
D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004292:Dominance, Cerebral / Q000187:drug effects; D004873:Ergolines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009530:Nicergoline / Q000627:therapeutic use*; D011877:Radionuclide Imaging; D012039:Regional Blood Flow / Q000187:drug effects; D014980:Xenon Radioisotopes
D004873:Ergolines; D014980:Xenon Radioisotopes; D009530:Nicergoline
Nicergoline et hémodétournement en faveur des zones d'hypodébit dans les accidents ischémiques cérébraux.