Estimating the fraction reabsorbed in drugs undergoing enterohepatic circulation.
A simple method of estimating the extent of biliary recycling using blood level and cumulative biliary excretion data from control and bile duct-cannulated animals is described. The method was tested in rats following an intravenous dose of [14C] temazepam. It was shown that 62% of the drug excreted in the bile of control rats was reabsorbed during each enterohepatic cycle, contributing to the secondary peak blood concentrations and a prolonged elimination half-life.
D000042:Absorption; D000818:Animals; D001646:Bile / Q000378:metabolism; D004764:Enterohepatic Circulation; D006207:Half-Life; D007700:Kinetics; D008297:Male; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013693:Temazepam / Q000378:metabolism
D004364:Pharmaceutical Preparations; D013693:Temazepam