[Hypolipemic action of various drugs in rats poisoned with Triton WR 1339].
We have tested the hypolipaemic activity of some drugs (Chlofibrate, Procetofene, Niadenate. Phenofibrate and Piridinol Carbamate), in rats with Triton-induced hyperlipaemia. At two dose levels (200 mg/kg b. wt and 400 mg/kg b. wt). Niadenate is the most active in both cases. Piridinol carbamate and phenofibrate show a similar activity, being able to decrease lipid levels nearly half as much as Niadenate in equal concentration of Triton 400 mg/kg b. wt. Procetofene is less active than Chlofibrate and Niadenate when Triton is used at 200 mg/kg b. wt.
D000818:Animals; D002784:Cholesterol / Q000097:blood; D002994:Clofibrate / Q000494:pharmacology; D011345:Fenofibrate / Q000031:analogs & derivatives / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008297:Male; D009539:Nicotinic Acids; D011092:Polyethylene Glycols / Q000037:antagonists & inhibitors / Q000633:toxicity*; D011727:Pyridinolcarbamate / Q000494:pharmacology; D051381:Rats
D000960:Hypolipidemic Agents; D008055:Lipids; D009539:Nicotinic Acids; D011092:Polyethylene Glycols; D011727:Pyridinolcarbamate; C036558:niadenate; D002784:Cholesterol; C006012:fenofibric acid; D002994:Clofibrate; D011345:Fenofibrate; C016811:tyloxapol
Acción hipolipemiante de diferentes fármacos en ratas intoxicadas con Tritón WR 1339.