The selectivity of the anorectic effect of satietin. I. The ineffectiveness of satietin on behavioral tests.
Satietin, a potent endogenous anorectic substance separated from human serum, plays a role of a rate limiting satiety signal in the negative feed back of food intake. The selectivity of satietin on some behavioral tests (unconditioned avoidance reaction, one-way as well as two-way conditioning, open field, consolidated conditioned reflex) was checked and compared to calcitonin. TRH and Glp-Leu-Pro-OH. Satietin seemed to be ineffective on all but one (open field) behavioral tests. Calcitonin and Glp-Leu-Pro-OH increased open field activity. Results indicate that satietin is an endogenous anorectic substance with a peculiar selectivity.
D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D002116:Calcitonin / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects; D005260:Female; D006020:Glycopeptides / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001067:Appetite Depressants; D006020:Glycopeptides; C035102:satietin; D002116:Calcitonin