Effects of chronic lithium, clorgyline, imipramine, fluphenazine and constant darkness on the alpha-melanotropin content and circadian rhythm in rat brain.
The effects of constant darkness, chronic lithium, clorgyline, imipramine and fluphenazine treatment on the content and diurnal rhythm of alpha-MSH in rat forebrain were investigated. The persistence of the alpha-MSH rhythm in constant darkness demonstrated that the rhythm was circadian in nature. Constant darkness increased the 24 h mean alpha-MSH concentration in brain while lithium, fluphenazine and imipramine decreased it. In addition, imipramine and clorgyline delayed the phase of the alpha-MSH circadian rhythm while lithium advanced it.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002940:Circadian Rhythm / Q000187:drug effects*; D003010:Clorgyline / Q000494:pharmacology; D003624:Darkness; D005476:Fluphenazine / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D008094:Lithium / Q000494:pharmacology; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011619:Psychotropic Drugs; D009074:Melanocyte-Stimulating Hormones; D008094:Lithium; D003010:Clorgyline; D007099:Imipramine; D005476:Fluphenazine