Maternal serum hormone changes during abortion induced with 9-deoxo-16, 16-dimethyl-9-methylene prostaglandin E2.
Serum hormone levels in women undergoing successful first and second trimester abortions induced by 9-deoxo-16, 16-dimethyl-9-methylene prostaglandin E2 vagitories have been measured. Significantly decreased levels of prolactin (p less than 0.01) and TSH (p less than 0.05) were seen in both groups of women but the drop appeared sooner, within two hours, in first trimester abortions. Regardless of gestational length there was a significant decrease in serum human chorionic gonadotropin (hCG) (p less than 0.01) concentrations in maternal serum six hours into treatment. In the second trimester abortions total estriol, alpha-fetoprotein and lactoplacental hormone hPL were analysed in maternal serum but the levels did not change over the eight hour investigation period. It is speculated that the PGE2-derivative most likely affects the maternal pituitary secretion of prolactin and TSH, possibly via direct or indirect interference with TRH mechanism(s).
D015064:16,16-Dimethylprostaglandin E2 / Q000031:analogs & derivatives / Q000627:therapeutic use*; D000028:Abortion, Induced; D000293:Adolescent; D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011388:Prolactin / Q000097:blood; D011459:Prostaglandins E, Synthetic / Q000627:therapeutic use*; D013972:Thyrotropin / Q000097:blood; D013997:Time Factors
D006063:Chorionic Gonadotropin; D006728:Hormones; D011459:Prostaglandins E, Synthetic; C025505:meteneprost; D011388:Prolactin; D013972:Thyrotropin; D015064:16,16-Dimethylprostaglandin E2