[Effect of excess phosphorus consumption on a phosphorus-calcium metabolism and bone tissue of rats under hypokinesia].
The exposure of rats fed with the diet containing Ca : P = 1 : 0.5 - 1 : 3 to hypokinesia produced hypocalcemia, osteoporosis and increased renal calcinosis. The reduced phosphorus consumption (Ca : P = 1 : 0.5 - 1 : 1) prevented these disorders in the intact animals and increased bone density in the hypokinetic rats. The excessive phosphorus consumption caused hypocalcemia, hyperphosphatemia and slight osteoporosis in both intact and hypokinetic rats, with the changes being more pronounced in those latter. It is concluded that the diet with Ca : P = = 1 : 0,5-1 : 1 is optimal for hypokinetic rats.
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D004032:Diet; D005269:Femur / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008297:Male; D010758:Phosphorus / Q000008:administration & dosage* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical
D010758:Phosphorus; D000469:Alkaline Phosphatase; D002118:Calcium
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