[Treatment of amibiasis with short-term secnidazole therapy].
The authors have treated: a) 48 cases of E. histolytica histolytica intestinal amoebiasis by a single dose of 35 mg/kg of secnidazole with 98 p. 100 of parasitological success; b) 122 cases of E. histolytica minuta with several procedures: a unique dose of 25 mg/kg gives no success in 16.6 p. 100 of the cases, but the same single dose during three days gets only 2 p. 100 of failure; c) 22 cases of hepatic amoebiasis by a daily dose of 25 to 33 mg/kg during 5 days with success in every cases. Tolerance has been excellent. These short cures, facilitated by the long half-life of secnidazole are particularly easy to apply in developing countries.
D000328:Adult; D000562:Amebiasis / Q000188:drug therapy*; D002648:Child; D004334:Drug Administration Schedule; D004404:Dysentery, Amebic / Q000188:drug therapy; D004749:Entamoebiasis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008101:Liver Abscess, Amebic / Q000188:drug therapy; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
D008795:Metronidazole; C016724:secnidazole
Le traitement de l'amibiase par le secnidazole en cure courte.