[Mutagenic activity of synthetic interferon inducers in laboratory mice].
The mutagenic activity of poly(I) . poly(C) and poly(G) . poly(C) complexes in somatic and generative cells of mice was tested. Both preparations exhibited mutagenic activity in both test-systems. The poly(I) . poly(C) complex in the three doses tested was found to be more active both in bone marrow cells and in sex cells of male mice. The maximum effectiveness of this complex was demonstrated upon treatment of postmeiotic cells of males in an intermediate dose of 2.5 mg/kg bw. The rate of induced dominant lethals was 19.1%. In bone marrow metaphases the subtoxic dose of this complex increased 10-fold the control value of structural aberrations. The activity of poly(G) . poly(C) was found to be slightly lower.
D000818:Animals; D002869:Chromosome Aberrations; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D007369:Interferon Inducers / Q000633:toxicity*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009153:Mutagens; D011066:Poly C / Q000633:toxicity*; D011068:Poly G / Q000633:toxicity*; D011070:Poly I-C / Q000633:toxicity*; D011131:Polyribonucleotides / Q000633:toxicity*; D011247:Pregnancy
D007369:Interferon Inducers; D009153:Mutagens; D011131:Polyribonucleotides; D011068:Poly G; C008961:poly G-poly C; D011066:Poly C; D011070:Poly I-C
Issledovanie mutagennoĭ aktivnosti sinteticheskikh induktorov interferona na laboratornykh myshakh.