Metabolic oxidation of desmethylchlorimipramine in vitro by 9000 g rabbit-liver preparations.
1. The metabolism of desmethylchlorimipramine (I) has been investigated in vitro using fortified 9000 g liver homogenates of male rabbits. 2. Four metabolic products: N-hydroxydesmethylchlorimipramine (II), 3-(3-chloro-10, 11-dihydro-5H-dibenz[b,f]azepin-5-yl)propanoic acid (III), 10/11-hydroxydesmethylchlorimipramine (IV) and 2/8-hydroxydesmethylchlorimipramine (V) were isolated and identified by electron-impact mass spectrometry and n.m.r. spectroscopy. 3. Desmethylchlorimipramine (I) undergoes both N- and alpha-carbon oxidation in addition to aromatic and alicyclic carbon oxidation.
D000818:Animals; D002855:Chromatography, Thin Layer; D002997:Clomipramine / Q000031:analogs & derivatives* / Q000378:metabolism; D008401:Gas Chromatography-Mass Spectrometry; D006900:Hydroxylation; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D011817:Rabbits
C012273:desmethylclomipramine; D002997:Clomipramine