Chemotherapy for advanced recurrent carcinoma of the cervix. A report on the treatment of 22 patients.
In 22 patients with advanced squamous-cell carcinoma of the cervix, chemotherapy with adriamycin and methotrexate was attempted. Remission occurred in five patients, being complete in two of these. The median duration of remission was 8 months. In eight patients, the course of the disease was stabilized for at least 3 months. The median survival time was 3 months for the group of "failures', 11.5 months for those with stable disease, and 21 months for patients in remission. The most favourable course of the disease was observed in the two patients with complete remission; they survived for 31 and 32 months, respectively, after the start of chemotherapy.
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D013534:Survival; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
D004317:Doxorubicin; D008727:Methotrexate