Pharmacokinetics of cefadroxil and cefaclor during an eight-day dosage period.
The concentrations of cefadroxil and cefaclor in serum were studied in eight healthy volunteers receiving 1,000 mg of both substances three times per day for 8 days. Intraindividual comparisons showed an increase in peak serum levels of cefadroxil from days 1 to 8 in seven of eight volunteers. Cefaclor peak concentrations did not rise during the 8 days.
D000328:Adult; D002433:Cefaclor / Q000378:metabolism*; D002434:Cefadroxil; D002506:Cephalexin / Q000031:analogs & derivatives* / Q000378:metabolism; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D002434:Cefadroxil; D002433:Cefaclor; D002506:Cephalexin