Naloxone decreases consumption of liquid and solid sucrose in vagotomized rats.
Intraperitoneal injections of the opiate antagonist naloxone decreased food intake in both vagotomized and sham-vagotomized rats. Consumption of liquid and solid sucrose, which were used in order to equate baseline intake, was equally suppressed in both groups under food-deprivation and appetitively-motivated conditions at all doses of naloxone (1, 2, 4, and 8 mg/kg). It is concluded that, in contrast to previous findings, the vagus nerve does not mediate the suppressive effects of naloxone on feeding behavior.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D005508:Food Deprivation; D008297:Male; D009042:Motivation / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D013395:Sucrose / Q000008:administration & dosage*; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*
D009270:Naloxone; D013395:Sucrose