[Study of the biological activity of spleen extracts containing inhibitor of DNA-ase I].
Fractions of calf spleen extracts possessing the increased potency to inhibit the activity of DNase 1 were obtained by chromatography on columns with Sephadex G-200 and CM-cellulose. The fractions containing the most powerful inhibitor of DNase 1 increased the survival rate of sublethally irradiated mice and hamsters. A possible role of the DNase 1 inhibitor in cure effects is discussed.
D000818:Animals; D002417:Cattle; D005591:Chemical Fractionation; D006224:Cricetinae; D003851:Deoxyribonucleases / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents; D013154:Spleen / Q000032:analysis / Q000201:enzymology*; D014020:Tissue Extracts / Q000627:therapeutic use
D011837:Radiation-Protective Agents; D014020:Tissue Extracts; D003851:Deoxyribonucleases
Izuchenie biologicheskoĭ aktivnosti selezenochnykh ékstraktov, soderzhashchikh ingibitor DNK-azy I.