A simple test for macromolecular heterogeneity in the analytical ultracentrifuge.
A simple check for the presence of heterogeneity in a macromolecular system is proposed, employing comparison of Rayleigh sedimentation-equilibrium patterns for two solutions of the same fringe concentration but differing absolute concentrations. The method is illustrated by application to a bronchial glycoprotein from a cystic-fibrosis patient.
D006023:Glycoproteins; D006801:Humans; D046911:Macromolecular Substances; D014461:Ultracentrifugation / Q000379:methods*
D006023:Glycoproteins; D046911:Macromolecular Substances