Posttraumatic splenic replantation in children.
Previous work in our laboratories showed that canine omental replantation of splenic wafers leads to reproducible viability, restoration of filtrative function, bacterial clearance, and normal antibody formation. An identical technique has been employed in children whose spleen could not be repaired since 1979. During a 3-yr follow-up viability of the replanted segments was documented with return of filtrative function, normal immunoglobulin, and antibody response. Splenic preservation through operative repair or selective nonoperative observation should remain the primary goal after splenic trauma. If this is not possible, splenic replantation represents an alternative approach in the treatment of splenic trauma.
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D001428:Bacterial Vaccines / Q000627:therapeutic use; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D011008:Pneumococcal Infections / Q000517:prevention & control; D011182:Postoperative Care; D011183:Postoperative Complications / Q000517:prevention & control; D012092:Replantation / Q000379:methods*; D013154:Spleen / Q000276:immunology / Q000293:injuries*; D013156:Splenectomy; D013296:Streptococcus pneumoniae / Q000276:immunology; D014949:Wounds, Nonpenetrating / Q000601:surgery*
D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines