A new antithrombogenic material with long polyethyleneoxide chains.
The PVC-g-MnG polymers were synthesized by photo-induced graft copolymerization of methoxypoly (ethyleneoxide)monomethacrylate (MnG) with various chain lengths (n) of polyethyleneoxide (PEO) (n = 4, 9, 15, 23, 50, 100) as side chains to polyvinylchloride (PVC) with photo-sensitive dithiocarbamate groups. Antithrombogenicity has been evaluated in vitro and in vivo. The in vitro and in vivo results indicated that the adsorption of blood elements to the PVC-g-MnG significantly decreased with the increasing PEO chain length (n). From these findings it is suggested that the volume restriction effect resulted from the formation of long-chain PEO on the surface and which effectively suppresses the adsorption of blood elements and prevents the denaturation of blood elements.
D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011109:Polymethacrylic Acids / Q000494:pharmacology*; D011143:Polyvinyl Chloride; D011817:Rabbits; D013329:Structure-Activity Relationship
D001672:Biocompatible Materials; D005343:Fibrinolytic Agents; D011109:Polymethacrylic Acids; C036663:polyvinyl chloride-methoxypoly(ethyleneglycol)monomethacrylate; D011092:Polyethylene Glycols; D011143:Polyvinyl Chloride