Radioresistance secondary to low pH in human glial cells and Chinese hamster ovary cells.
The influence of the extracellular pH on the radiosensitivity of human glial cells and Chinese hamster ovary cells was examined. The period of low pH varied from 0 to 96 hours in glial cells and from 0 to 48 hours in Chinese hamster cells. Maintenance of low pH after a dose of 10 Gy for at least 24 hours for glial cells and at least 6 hours for Chinese hamster cells improved survival by more than one order of magnitude at pH 6.4. Cellular inactivation by irradiation may be impaired by an extracellular pH at or below pH 6.7.
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009457:Neuroglia / Q000528:radiation effects*; D010053:Ovary / Q000166:cytology; D011836:Radiation Tolerance