The neuromuscular blocking action of suxamethonium following intravenous and intramuscular administration.
In 35 anesthetized adult patients the neuromuscular blocking effect of suxamethonium (0.8-2.4 mg X kg-1) following i.v. or i.m. administration was studied by means of mechanomyograms of the hand muscles after electrical stimulation of the ulnar nerve (0.2 Hz, 100-120 volts, 0.2 ms). Compared with i.v. suxamethonium (= 1.0) the myoneural blocking activity of i.m. suxamethonium was less effective (0.128), the rate of onset slower (0.174), and the duration of action longer (1.4 to 1.7). According to the dose-response relationship, suxamethonium 3.0-4.0 mg X kg-1 should be administered i.m. to achieve complete neuromuscular blockade.
D000328:Adult; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents; D009469:Neuromuscular Junction / Q000187:drug effects; D013390:Succinylcholine / Q000008:administration & dosage* / Q000494:pharmacology; D013997:Time Factors
D009466:Neuromuscular Blocking Agents; D013390:Succinylcholine