Comparative effects of 5'-amino-5'-deoxythymidine, a new antiviral agent, and 5-iodo-2'-deoxyuridine on the immune response of mice. No immunosuppression with 5'-amino-5'-deoxythymidine.
Immunological function was analyzed in mice that received daily inoculations of 5'-amino-5'-deoxythymidine (1000 mg/kg/day, i.p.) or 5-iodo-2'-deoxyuridine (100 mg/kg/day, i.p.) following antigenic stimulation. 5' Amino-5'-deoxythymidine did not suppress the development of: (1) delayed type hypersensitivity response to sheep red blood cells, (2) cell-mediated cytotoxicity response to allogeneic tumor cells, and (3) IgM and IgG antibody response to sheep red blood cells. In contrast 5-iodo-2'-deoxyuridine suppressed the development of all of these responses.
D000818:Animals; D000998:Antiviral Agents / Q000633:toxicity*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D015224:Dideoxynucleosides; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006968:Hypersensitivity, Delayed; D007065:Idoxuridine / Q000633:toxicity*; D007109:Immunity / Q000187:drug effects*; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007166:Immunosuppressive Agents; D051379:Mice; D008810:Mice, Inbred C57BL; D013936:Thymidine / Q000031:analogs & derivatives* / Q000633:toxicity
D000998:Antiviral Agents; D015224:Dideoxynucleosides; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007166:Immunosuppressive Agents; C024082:5'-amino-5'-deoxythymidine; D007065:Idoxuridine; D013936:Thymidine