[Biochemical shifts in the blood plasma of dogs in multiple G-load exposure].
For 3 months experimental dogs were exposed to +Gz acceleration applied 3 times a day for 3 days a week. The initial acceleration value was 8-9 G, then the parameter varied, depending on the tolerance limit which was evaluated with respect to heart rate disorders. Biochemical measurements showed the largest changes (decrease in total protein, increase in sugar, bilirubin, cholesterol, alkaline phosphatase and transaminases) after the first day of the repeated exposure to +Gz. Following 1-3 months of the exposure, the changes decreased significantly; however, the K+ concentration continued to decline and that of alkaline phosphatase continued to increase. The results obtained indicate the development of adaptation to repeated +Gz exposures which differs from that to short-term exposures.
D000054:Acceleration / Q000009:adverse effects; D000222:Adaptation, Physiological; D000818:Animals; D001769:Blood / Q000378:metabolism*; D004285:Dogs; D006112:Gravitation; D008297:Male; D013997:Time Factors
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