title: [Morphogenesis of experimental cancer of the large intestine (according to the results of scanning electron and light microscopy)].
abstract: Colon tumors induced by 1.2-dimethylhydrazine in mice were studied by scanning electron microscopy followed by light microscopy. The following morphological types of tumors were demonstrated: adenomatous polyps (82%) with folded and smooth patterns of the surface structure, hyperplastic polyps (13.8%), endophytic carcinoma (3.7%), and few villous tumors. In the majority of the cases carcinoma developed due to malignisation of morphologically benign adenomatous and more rarely hyperplastic polyps. Endophytic carcinoma developed without benign precursors. Villous tumors had a high potential for malignisation. All these kinds of tumors arose in diffuse hyperplastic colon mucosa.
mesh_terms: D019813:1,2-Dimethylhydrazine; D000230:Adenocarcinoma / Q000473:pathology*; D000236:Adenoma / Q000473:pathology*; D000818:Animals; D002273:Carcinogens; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000473:pathology*; D004127:Dimethylhydrazines; D005260:Female; D006824:Hybridization, Genetic; D006965:Hyperplasia; D007417:Intestinal Polyps / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008855:Microscopy, Electron, Scanning; D051381:Rats
chemical_list: D002273:Carcinogens; D004127:Dimethylhydrazines; D019813:1,2-Dimethylhydrazine
vernacular_title: Morfogenez éksperimental'nogo raka tolstoĭ kishki (po dannym rastrovoĭ élektronnoĭ i svetovoĭ mikroskopii).