Folic acid derivatives do not reproduce the neurotoxic effects of kainic acid on chicken retina.
Methyltetrahydrofolic acid, formyltetrahydrofolic acid, folic acid and dihydrofolic acid were injected intravitreally into the eyes of chickens. No short-term or long-term signs of neurotoxicity were observed, even when doses 100-200 times those at which kainic acid produces clear neurotoxic effects were injected. The folic acid derivatives neither inhibited nor potentiated the neurotoxic effects. Thus no support is given to the suggestion that folic acid and its derivatives may act as kainic acid agonists or antagonists, even though the receptors involved in kainic acid-induced neurotoxicity appear to be of the kainic acid rather than quisqualic acid or N-methyl-D-aspartic acid type.
D000818:Animals; D002645:Chickens; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005492:Folic Acid / Q000031:analogs & derivatives* / Q000633:toxicity*; D005575:Formyltetrahydrofolates / Q000633:toxicity; D007608:Kainic Acid / Q000633:toxicity*; D011759:Pyrrolidines / Q000633:toxicity*; D012160:Retina / Q000187:drug effects*; D013763:Tetrahydrofolates / Q000633:toxicity
D005575:Formyltetrahydrofolates; D011759:Pyrrolidines; D013763:Tetrahydrofolates; C010920:dihydrofolate; D005492:Folic Acid; D002795:Choline O-Acetyltransferase; D007608:Kainic Acid; C005984:5-methyltetrahydrofolate