Ocular toxicity of 2,2,2-trifluoroethanol in rabbits.
Three commercial formulations of 2,2,2-trifluoroethanol (TFE) were applied to eyes of rabbits and evaluated for their potential to cause ocular damage. All three products were severe eye irritants and water irrigation shortly after exposure was not effective in reducing ocular damage. Gross and histological observations revealed marked conjunctivitis, moderate to severe ulcerative keratitis, and hyperemia and edema of the iris, all of which showed evidence of resolution over the three-week course of investigation. However, complete reversal of all effects was not attained. TFE and its commercial formulations should be viewed as potentially severe human ocular irritants.
D000818:Animals; D003315:Cornea / Q000473:pathology; D000431:Ethanol / Q000031:analogs & derivatives*; D005123:Eye / Q000187:drug effects* / Q000473:pathology; D006863:Hydrogen-Ion Concentration; D007509:Irritants / Q000633:toxicity; D009336:Necrosis; D011817:Rabbits; D014270:Trifluoroethanol / Q000633:toxicity*
D007509:Irritants; D000431:Ethanol; D014270:Trifluoroethanol