[Antimalarial 6-aminoquinolines. XIII. 5,8-Dialkoxyderivatives of 6-(4-diethylamino-1-methylbutylamino)-2-methyl- and 6-(4-diethylamino-1-methylbutylamino)-2,4-dimethylquinoline (author's transl)].
13 analogues 3c-p of 6-(4-diethylamino-1-methylbutylamino)-5,8-dimethoxy-2-methylquinoline (2a) and 6-(4-diethylamino-1-methylbutylamino)-5,8-dimethoxy-2,4-dimethylquinoline (2b) were synthesized with variations of alkoxysubstituents (-O-n-C4H9, -O-n-C8H17, -O CH(CH3)2, -O(CH2)2OCH3, -O(CH2-CH2O)2CH3, -O(CH2)2N(C2H5)2) in positions 5 and(or) 8 with the aim of studying the influence on antimalarial activity and toxicity. All derivatives were active against P, vinckei (mouse).
D000634:Aminoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D051379:Mice; D010961:Plasmodium / Q000187:drug effects
D000634:Aminoquinolines; D000962:Antimalarials
Gegen Malaria wirksame 6-Aminochinoline. XIII. 5,8-Dialkoxyderivate von 6-(4-Diäthylamino-1-methylbutylamino)-2-methyl- und 6-(4-Diäthylamino-1-methylbutylamino)-2,4-dimethylchinolin.