Effect of estradiol and progesterone on glucosamine 6-phosphate synthase in the uterus of rat.
Injection of estradiol to ovariectomised rats caused significant increase in the activity of glucosamine 6-phosphate synthase of uterus. Progesterone did not cause any increase in the activity of the enzyme; however, it antagonised the effect of estradiol. It was observed that the enzyme is predominantly localised in the endometrium of uterus.
D000818:Animals; D002238:Carbohydrate Epimerases / Q000378:metabolism*; D002369:Castration; D004054:Diethylstilbestrol / Q000494:pharmacology; D004717:Endometrium / Q000201:enzymology; D004958:Estradiol / Q000494:pharmacology*; D004965:Estrogen Antagonists / Q000494:pharmacology; D005260:Female; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / Q000378:metabolism*; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D013739:Testosterone / Q000494:pharmacology; D014599:Uterus / Q000187:drug effects / Q000201:enzymology*
D004965:Estrogen Antagonists; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D004054:Diethylstilbestrol; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); D002238:Carbohydrate Epimerases