Some new 1-(2'-methyl-6'-methoxy-quinoline-4'-yl amino)-2-methyl-4-arylidene-imidazolin-5-ones as anticonvulsant and analgesic agents.
Seventeen new 1-(2'-methyl-6'-methoxyquinoline-4'-yl-amino)-2-methyl-4-arylideneimidazol-5-ones have been synthesized by the condensation between the respective azlactones (prepared by the well known Erlenmeyer azlactone synthesis) and 2-methyl-4 hydrazino-6-methoxy-quinolines. The compounds have been found to possess anticonvulsant activity against maximal electroshock seizures and chemoshock induced seizures and the analgesic activity. Some qualitative structure activity relationship has been established.
D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D004597:Electroshock; D005260:Female; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011930:Reaction Time / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced; D013329:Structure-Activity Relationship
D000700:Analgesics; D000927:Anticonvulsants; D007093:Imidazoles