Histidyl-proline diketopiperazine decreases food intake in rats.
Histidyl-proline diketopiperazine was found to suppress food intake during stress-induced eating (10(-6)--10(-8) mol), starvation-induced eating (10(-8) mol) and over an 8 h period of spontaneous eating (10(-8) mol). In contrast, other cyclic piperazines failed to alter food ingestion. The suppressive effect of histidyl-proline diketopiperazine was antagonized by the enkephalin analogue, D-Ala-Met-enkephalin, in equimolar concentrations.
D000818:Animals; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives*; D004745:Enkephalins / Q000494:pharmacology; D005247:Feeding Behavior / Q000187:drug effects*; D006801:Humans; D008297:Male; D010456:Peptides, Cyclic / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D013217:Starvation; D013315:Stress, Psychological; D013329:Structure-Activity Relationship
D004745:Enkephalins; D010456:Peptides, Cyclic; D010879:Piperazines; D004744:Enkephalin, Methionine; C013801:enkephalin-Met, Ala(2)-; C015924:histidyl-proline diketopiperazine