[DNA molecule interaction in the contact mechanism of chromosome aberration formation].
The scheme of the formation of structural chromosome mutations, based on hydrogen binding of double-stranded DNA in the sites of palindrome sequencies is proposed. According to this scheme the mutagen damage in palindromes, forming chromosome loops, leads to the formation of structural mutations. In lack of contact between double-stranded regions of chromosomes the restoration of its structure occurs. The molecular mechanism of the formation of structural chromosome mutation is considered from the point of view of repair hypothesis and explains the gene position effect.
D000818:Animals; D001483:Base Sequence; D055598:Chemical Phenomena; D002621:Chemistry; D002869:Chromosome Aberrations; D007446:Chromosome Inversion; D002875:Chromosomes / Q000528:radiation effects / Q000648:ultrastructure; D003434:Crossing Over, Genetic; D004247:DNA; D006860:Hydrogen Bonding; D008957:Models, Genetic; D009153:Mutagens / Q000494:pharmacology; D009154:Mutation; D014178:Translocation, Genetic
D009153:Mutagens; D004247:DNA
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