Gyromitrin as a tumor inducer.
Acetaldehyde methylformylhydrazone (gyromitrin) was administered in propylene glycol as 12 weekly subcutaneous injections of 50 micrograms/g weight to randomly bred Swiss mice. The treatment induced lung and preputial gland tumors in incidences of 51 and 0% in females and 46 and 28% in males, respectively. In the propylene glycol injected control groups, the corresponding tumor incidences were 28 and 0% in females and 32 and 0% in males. Histopathologically, the tumors were classified as adenomas and adenocarcinomas of the lungs and squamous cell papillomas and carcinomas and adenocarcinomas of preputial glands. Gyromitrin is an ingredient of the wild edible false morel mushroom Gyromitrin esculenta. The environmental significance of the findings is discussed.
D000079:Acetaldehyde / Q000031:analogs & derivatives* / Q000633:toxicity; D000230:Adenocarcinoma / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D001487:Basidiomycota; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D051379:Mice; D009183:Mycotoxins; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced; D010412:Penile Neoplasms / Q000139:chemically induced*; D011409:Propylene Glycols / Q000633:toxicity
D002273:Carcinogens; D009183:Mycotoxins; D011409:Propylene Glycols; D000079:Acetaldehyde; C005666:gyromitrin