title: [Determination of p-aminoacetophenone and changes in its levels in a levorin producer depending on culture conditions].
abstract: A method for spectrophotometric determination of p-aminoacetophenone (p-AAP) in the mycelium and fermentation broth filtrates of organisms producing polyenic macrolide antibiotics is described. The level of p-AAP accumulation was studied as applicable to the biosynthesis of levorin, a polyenic antibiotic of the heptaen series. The levels of p-AAP under usual conditions of the levorin-producing organism cultivation and under conditions of its stimulation with the products of the vital activity of yeast-like fungi were compared. Higher levels of p-AAP in the cultures grown with stimulation of the antibiotic biosynthesis were noted. Inadequacy of the correlation between production of levorin and p-AAP is discussed.
mesh_terms: D000098:Acetophenones / Q000032:analysis* / Q000378:metabolism; D000935:Antifungal Agents / Q000096:biosynthesis*; D002174:Candicidin / Q000096:biosynthesis*; D002175:Candida / Q000254:growth & development; D003470:Culture Media; D005609:Free Radicals; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000032:analysis* / Q000378:metabolism
chemical_list: D000098:Acetophenones; D000935:Antifungal Agents; D003470:Culture Media; D005609:Free Radicals; D002174:Candicidin; C032065:4-aminoacetophenone
vernacular_title: Opredelenie p-aminoatsetofenona i izmenenie ego urovnia u produtsenta levorina v zavisimosti ot usloviĭ kul'tivirovaniia.