Interaction of the B locus and the GVHR-selected lines in the graft-versus-host reaction in chickens.
Genetic differences affecting the degree of splenomegaly in the graft-versus-host reaction (GVHR) of chickens were studied. Two B genotypes, B9 B9 and B11 B11, and two GVHR-selected lines, H and L, were examined. The degree of splenomegaly of B9 B9 leads to B11 B11 was significantly higher than that of B11 B11 leads to B9 B9 for all line combinations. In contrast, the inoculation of H into L gave consistently higher splenomegaly than that of L into H. This suggested that the effects of B locus were higher in hosts than in donors, while those of the GVHR-selected lines were higher in donors than in hosts. The analysis of variance revealed that both the differences between the reciprocal combination of B genotypes and between the GVHR line combinations were statistically highly significant. Furthermore, the interaction of B genotypes and GVHR lines was also highly significant.
D000017:ABO Blood-Group System / Q000276:immunology; D000483:Alleles; D000818:Animals; D002642:Chick Embryo; D002645:Chickens / Q000276:immunology*; D005260:Female; D005838:Genotype; D006087:Graft vs Host Reaction; D008285:Major Histocompatibility Complex; D008297:Male; D012737:Sex Factors; D013163:Splenomegaly / Q000276:immunology
D000017:ABO Blood-Group System