Further observations on a 13qXp translocation associated with retinoblastoma.
In a patient with a 13qXp translocation and retinoblastoma the band associated with retinoblastoma (13q14) was clearly translocated intact to the X chromosome rather than being the breakpoint of the translocation. Genetic inactivation of the derivative X chromosome shown by late labeling and cell hybridization techniques in the predominance of cells indicated a functional monosomy for this segment as the most likely predisposing factor in producing retinoblastoma.
D002901:Chromosomes, Human, 13-15; D005134:Eye Neoplasms / Q000235:genetics*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D012175:Retinoblastoma / Q000235:genetics*; D012730:Sex Chromosomes; D014178:Translocation, Genetic; D014960:X Chromosome
D005954:Glucosephosphate Dehydrogenase