Sinus histiocytosis with massive lymphadenopathy: a case with unusual skin involvement and a therapeutic response to vinblastine-loaded platelets.
A patient with sinus histiocytosis with massive lymphadenopathy had unusual skin lesions and progressive internal involvement. Both aspects responded dramatically to the administration of vinblastine-loaded platelets. Vinblastine-loaded, idiopathic thrombocytopenic purpura antibody-coated platelets are a rationale therapy for a disease characterized by the presence of actively phagocytosing histiocytes.
D000906:Antibodies / Q000008:administration & dosage; D001792:Blood Platelets; D001803:Blood Transfusion; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008206:Lymphatic Diseases / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008231:Lymphopenia; D008297:Male; D008875:Middle Aged; D010587:Phagocytosis; D011379:Prognosis; D011696:Purpura, Thrombocytopenic / Q000276:immunology; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D014747:Vinblastine / Q000008:administration & dosage*
D000906:Antibodies; D014747:Vinblastine