Biological properties of 16 alpha-hydroxyestrone: implications in estrogen physiology and pathophysiology.
Metabolism of estradiol in men with cirrhosis and subjects with systemic lupus erythematosus results in an excessive formation of 16 alpha-hydroxyestrone. Examination of the biological activity of this metabolite showed that it is a potent uterotropic agent and that it exhibits minimal affinity for the human sex hormone-binding globulin. These biological characteristics are consistent with a hyperestrongenic response to the substance, which may be reflected in the pathology and etiology of these diseases.
D000818:Animals; D002369:Castration; D004958:Estradiol / Q000378:metabolism; D004964:Estriol / Q000378:metabolism; D004967:Estrogens / Q000494:pharmacology / Q000502:physiology*; D004970:Estrone / Q000031:analogs & derivatives*; D005260:Female; D006894:Hydroxyestrones / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood; D051381:Rats; D011960:Receptors, Estrogen / Q000378:metabolism; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D014599:Uterus / Q000187:drug effects / Q000378:metabolism
D004967:Estrogens; D006894:Hydroxyestrones; D011960:Receptors, Estrogen; D012738:Sex Hormone-Binding Globulin; C026702:16-hydroxyestrone; D004970:Estrone; D004958:Estradiol; D007986:Luteinizing Hormone; D004964:Estriol