Effect of fibrinolysis inhibitor and chemotherapeutics on the growth of human cancers transplanted into nude mice and in tissue culture.
Effects of tranexamic acid (AMCHA) alone or together with anticancer drug on the growth of human cancers transplanted into nude mice and in tissue culture were investigated. AMCHA showed no effects on cancer cells in vitro. Fibrin deposition and host stromal reaction at the advancing border of the tumor tended to increase after AMCHA administration. These seem to contribute to the significant reduction of tumor growth rate by AMCHA in combination with an anticancer drug compared to control.
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D046508:Culture Techniques; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D005337:Fibrin / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014148:Tranexamic Acid / Q000378:metabolism / Q000627:therapeutic use*
D003509:Cyclohexanecarboxylic Acids; D014148:Tranexamic Acid; D005337:Fibrin