Effect of niludipine on ischemic myocardial metabolism in the dog.
The effect of pretreatment with 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine carbonic acid-bis(2-propoxyethyl) ester (niludipine, Bay a 7168) (10 microgram/kg i.v.) on myocardial metabolic response to coronary artery ligation was studied in dogs anesthetized with pentobarbital. The results are summarized as follows: 1. Bay a 7168 lowered systolic and diastolic blood pressures markedly, and decreased heart rate slightly. 2. Bay a 7168 increased the endo- and epicardial phosphorylase activity significantly. 3. Bay a 7168 increased the endo- and epicardial ATP levels significantly. 4. Coronary artery ligation increased the endo- and epicardial activity of phosphorylase and decreased the endo- and epicardial glycogen levels. 5. In the presence of Bay a 7168, acceleration of glycogenolysis being caused by coronary artery ligation, was not detected. 6. Changes in the levels of myocardial carbohydrate intermediates being caused by coronary artery ligation, were not modified by pretreatment with Bay a 7168.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000378:metabolism*; D003331:Coronary Vessels / Q000502:physiology; D004285:Dogs; D005260:Female; D005636:Fructosephosphates / Q000378:metabolism; D005958:Glucosephosphates / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D009543:Nifedipine / Q000031:analogs & derivatives / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D013997:Time Factors
D005636:Fructosephosphates; D005958:Glucosephosphates; D011725:Pyridines; D000255:Adenosine Triphosphate; D006003:Glycogen; C019497:niludipin; D009543:Nifedipine