Predictors of the outcome of transsphenoidal surgery for prolactin-secreting pituitary adenomas.
Sixty-seven women who underwent transsphenoidal resection of PRL-secreting pituitary adenomas between 1976 and 1979 were separated into categories according to the manner of their clinical presentation. Forty-one had oral contraceptive-related onset of amenorrhea-galactorrhea, 5 had pregnancy-related onset of amenorrhea-galactorrhea, 5 had primary amenorrhea, and 16 had the spontaneous onset of amenorrhea-galactorrhea unrelated to estrogen use. Surgical success, defined as the resumption of regular menses and normalization of serum PRL concentration, was achieved in 54% of those with estrogen-related onset of amenorrhea-galactorrhea compared with 19% in the other group. The analysis of multiple preoperative features, including clinical classification, age, preoperative PRL concentration, and duration of amenorrhea-galactorrhea by logistic regression, demonstrated that the clinical classification was the most important factor in predicting the outcome of transsphenoidal surgery. It should be a prime consideration in the selection of therapy for PRL-secreting adenomas.
D000236:Adenoma / Q000378:metabolism / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D005687:Galactorrhea / Q000209:etiology; D006801:Humans; D008598:Menstruation; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000601:surgery*; D011247:Pregnancy; D011379:Prognosis; D011388:Prolactin / Q000097:blood / Q000378:metabolism*
D011388:Prolactin