title: [Morphological recovery in the polycystic ovaries of persistent-estrus rats induced by continuous illumination (author's transl)].
abstract: When mature female rats having been showing at least 2 consecutive 4-day estrous cycles were raised in a room with continuous lighting (LL), their vaginal smear pattern became irregular by 7 to 9 days. and a persistent-estrus (P-E) appeared around 25 to 75 days of exposure. Ovaries from LL-exposed rats showing irregular cycles or P-E had signs of cystic follicles and anovulatory polycystic follicles, respectively. When P-E rats were placed again under the light-dark cycling condition (14L: 10D; Lights on 05: 00 h), the regular 4-day cycles were recovered soon and ovarian structures became normal after about 5 cycles. In P-E rats injected i.v. with 10 microgram LH/day at 4-day intervals under the LL condition, the regular estrous cycle reappeared and ovarian structures became normal after 5 administrations. These results suggest that the polycystic ovary of P-E rat induced by LL is reversible with cyclic stimulation by LH.
mesh_terms: D000818:Animals; D004971:Estrus; D005260:Female; D008027:Light; D007986:Luteinizing Hormone / Q000494:pharmacology*; D010048:Ovarian Cysts / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D010053:Ovary / Q000473:pathology; D010507:Periodicity; D011247:Pregnancy; D051381:Rats / Q000502:physiology*; D011919:Rats, Inbred Strains; D012376:Rodent Diseases / Q000209:etiology / Q000473:pathology*; D013997:Time Factors
chemical_list: D007986:Luteinizing Hormone