Carcinogenesis of 4-(hydroxymethyl)benzenediazonium ion (tetrafluoroborate) of Agaricus bisporus.
4-(Hydroxymethyl)benzenediazonium tetrafluoroborate was administered as 26 weekly s.c. injections of 50 microgram/g body weight to randomly bred Swiss mice. In addition, as a solvent control, sodium tetrafluoroborate was given as 26 weekly s.c. injections at 25 microgram/g body weight in 0.9% NaCl solution to another group of mice. The 4-(hydroxymethyl)benzenediazonium tetrofluoroborate treatment induced tumors in the subcutis and skin in incidence of 20 and 12%, respectively; while in the solvent sodium tetrafluoroborate-injected mice, the corresponding tumor incidence were 6 and 0%, respectively. Histopathologically, the tumors were classified as a fibroma, fibrosarcomas, rhabdomyosarcomas, and an angiosarcoma in the subcutis and also as squamous cell papillomas and carcinomas of the skin. 4-(Hydroxymethyl)benzenediazonium ion is an ingredient of the cultivated mushroom of commerce Agaricus bisporus.
D000818:Animals; D001487:Basidiomycota; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology; D003979:Diazonium Compounds / Q000633:toxicity*; D005260:Female; D005350:Fibroma / Q000139:chemically induced / Q000473:pathology; D005354:Fibrosarcoma / Q000139:chemically induced / Q000473:pathology; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced / Q000473:pathology; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology; D013997:Time Factors
D002273:Carcinogens; D003979:Diazonium Compounds; C030835:4-(hydroxymethyl)benzenediazonium ion