title: [Research on the central activity and analgesia of N-substituted analogs of the amphetamine derivative 3,4-methylenedioxyphenylisopropylamine].
abstract: N-substituted analogs of 3,4-methylenedioxyphenylisopropylamine (MDA) were tested ror analgesic potency and influence on motor activity in mice following potency and influence on motor activity in mice following oral administration. These compounds also were tested for thei psychotomimetic potency in man. Unsubstituted MDA and its monoalkyl-homologs with a low number of C-atoms (N-methyl-, N-methyl-, N-ethyl-MDA) showed both enhancement of motor-activity in mice and psychotomimetic effects in man. MDA and N-methyl-MDA also showed an analgesic effec wthich was enhanced by the inclusion of a weakly labis group (N-mallyl, N-hydroxyethyl). These latter two compounds, however, did not influence motor-activity, which makes them more recommendable as possible analgesic compounds. Structural parallels between these compounds, morphine, endorphins and enkephalins, may explain their similar spectrum of pharmacological effects.
mesh_terms: D015104:3,4-Methylenedioxyamphetamine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000662:Amphetamines / Q000494:pharmacology*; D000700:Analgesics; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002491:Central Nervous System Agents; D055598:Chemical Phenomena; D002621:Chemistry; D006213:Hallucinogens; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
chemical_list: D000662:Amphetamines; D000700:Analgesics; D002491:Central Nervous System Agents; D006213:Hallucinogens; C008534:MMDA; D015104:3,4-Methylenedioxyamphetamine
vernacular_title: Prüfung auf zentrale Aktivität und Analgesie von N-substituierten Analogen des Amphetamin-Derivates 3,4-Methylendioxyphenylisopropylamin.