title: [Organ and species factor in the phenomenon of tetracycline interaction with animal subcellular fractions].
abstract: Binding of the tetracyclines by the cell components of various organs of rats was studied comparatively. It was shown that binding of the tetracyclines by the subcellular fractions was decreasing as follows: the liver, the heart, the kidneys. The mitochondria were the fraction most actively binding the antibiotics. For determination of the features of this process the characteristics of tetracycline binding by the liver organoids of the rats and rabbits were compared. The quantitative indices of binding of the tetracyclines by the cell components of the rats and rabbits were rather similar.
mesh_terms: D000818:Animals; D005260:Female; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013347:Subcellular Fractions / Q000378:metabolism; D013754:Tetracyclines / Q000378:metabolism*
chemical_list: D013754:Tetracyclines
vernacular_title: Organnyĭ i vidovoĭ faktor v fenomene vzaimodeĭstviia tetratsiklinov s subkletochnymi fraktsiiami zhivotnykh.