Dioxychlorane: a challenge to the correlation of anesthetic potency and lipid solubility.
Dioxychlorane is a five-membered cyclic halogenated diether which has been reported to be anesthetic at an inspired concentration of 0.3% atm and to have an oil/gas partition coefficient to 260 to 275. These values suggested that dioxychlorane might represent a significant deviation from the correlation of anesthetic potency with lipid solubility. However, the results of this study did not confirm the above data: MAC in four dogs was 0.11 +/- 0.02 (SE) % atm, and the oil/gas partition coefficient was 1,286 +/- 44. Dioxychlorane appears not to be an exception to the correlation of anesthetic potency with lipid solubility.
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004148:Dioxolanes / Q000494:pharmacology*; D004149:Dioxoles / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D008055:Lipids; D012995:Solubility
D000777:Anesthetics; D004148:Dioxolanes; D004149:Dioxoles; D008055:Lipids; C022935:dioxychlorane