Mechanical hyperventilation: effect on specialized atrioventricular conduction, supraventricular refractoriness, and experimental atrial arrhythmias in dogs anesthetized with pentobarbital or pentobarbital-halothane.
The effect of hypocapnia (PCO2ET 25 vs 40 torr) on specialized atrioventricular (AV) conduction, supraventricular refractory periods, and experimental atrial arrhythmias provoked by premature atrial stimulation (atrial echoes-echoes, repetitive atrial firing (RAF)) was assessed in dogs anesthetized with pentobarbital or pentobarbital-halothane (1.0% end-tidal). Catheter His bundle electrocardiography was used. Both hypocapnia and halothane prolonged AV nodal conduction, but the effect of halothane was more pronounced. Halothane prolonged the atrial functional (AtFRP), atrial effective (AtERP), and AV nodal functional refractory (AVFRP) periods. These effects of halothane were linked to an increased incidence of RAF but not to echoes. Hypocapnia prolonged the AVFRP (less than halothane), had no effect on the AtFRP and shortened the AtERP. These effects of hypocapnia were associated with an increased incidence of echoes, but not with RAF. Echoes and RAF are thought to be caused by reentry within the sinus node, atria, and AV node. The differing effects of halothane and hypocapnia on the incidence of these arrhythmias may be due to differning effects on supraventricular refractoriness.
D000758:Anesthesia / Q000009:adverse effects*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D004285:Dogs; D006221:Halothane / Q000009:adverse effects; D006329:Heart Conduction System / Q000187:drug effects / Q000503:physiopathology*; D006985:Hyperventilation / Q000150:complications* / Q000503:physiopathology; D009431:Neural Conduction / Q000187:drug effects; D010424:Pentobarbital / Q000009:adverse effects; D012032:Refractory Period, Electrophysiological / Q000187:drug effects
D010424:Pentobarbital; D006221:Halothane