title: [Binding of a series of estrogens to the estrogen receptor system of guinea pig hypothalamo-hypophyseal structures].
abstract: The specificity of estrogen-receptor (ER) interaction was studied in cytosols of the adenohypophysis and anterior hypothalamus of guinea-pigs. The fundamental condition of active ER binding was shown to be the integrity of 17 beta- and C3-positions of the estradiol molecule excepting compounds with the combination of 17 beta-OH and 17 alpha-ethinyl groups. Significant differences were demonstrated in the affinity of the test compounds to ER systems of hypophyseal and hypothalamic cytosols.
mesh_terms: D000818:Animals; D003600:Cytosol / Q000378:metabolism; D004054:Diethylstilbestrol / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism*; D006168:Guinea Pigs; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D004967:Estrogens; D011960:Receptors, Estrogen; D004958:Estradiol; D004054:Diethylstilbestrol
vernacular_title: Izuchenie osobennosteĭ sviazyvaniia riada éstrogenov s éstrogen-retseptornymi sistemami gipotalamo-gipofizarnykh struktur morskikh svinok.