[Studies on the analysis of propafenone by means of internal analogue standardization (author's transl)].
A high-pressure liquid chromatographic method with internal analogue standardization is described for the determination of 2'-(2-hydroxy-3-propylamino-propoxy)-3-phenylpropiophenone hydrochloride (propafenone, Rytmonorm) in plasma. The requirement of selectivity is met: there is no interference of plasma components and propafenone metabolites found in plasma extracts. When using a 2-ml sample the lower limit of detection is approximately 1 ng/ml, the lower limit of determination about 5 ng/ml. In the concentration range up to 250 ng/ml a mean weighted relative error of about 3% has to be expected.
D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D011405:Propafenone; D011427:Propiophenones / Q000097:blood*
D011427:Propiophenones; D011405:Propafenone
Untersuchungen zur Analytik von Propafenon mittels interner Analogstandardisierung.