Effect of microphase separated structure of polystyrene/polyamine graft copolymer on adhering rat platelets in vitro.
Rat platelet adhesion on microphase separated surface of polystyrene/polyamine graft copolymers (SA copolymers) was investigated. Shapes of adhering platelet were very much changeable in response to the mode of microphase separation of SA copolymer surfaces. We assume that the microphase separated structure of SA copolyer may regulate the shape change of platelet through its effect on a redistribution of proteins and/or lipids present at the plasma membrane of platelets.
D000818:Animals; D001672:Biocompatible Materials; D001792:Blood Platelets / Q000648:ultrastructure; D002462:Cell Membrane / Q000648:ultrastructure; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D008297:Male; D008855:Microscopy, Electron, Scanning; D010973:Platelet Adhesiveness; D011137:Polystyrenes; D019736:Prostheses and Implants; D051381:Rats; D011919:Rats, Inbred Strains
D001672:Biocompatible Materials; D011137:Polystyrenes; C036557:poly(4-diethylaminoethylstyrene); C036556:polystyrene polyamine copolymer