Changes in the lysosomes and mitochondria isolated from the liver, kidney and heart of rats treated with perhexiline maleate.
A seven-days treatment, with Perhexilline Maleate induces changes in the structural latency of lysosomes isolated from liver or kidney and of the respiratory activity of mitochondria isolated from liver, kidney or heart. While the effect on lysosomal structural latency appears very similar in the liver and kidney lysosomes, the oxidative properties of liver mitochondria appears clearly more disturbed than those of the heart or kidney. It is concluded that liver mitochondria might be strongly involved in the mechanism of Perhexiline Maleate hepatotoxicity.
D000118:Acetylglucosaminidase / Q000378:metabolism; D000818:Animals; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects* / Q000648:ultrastructure; D008099:Liver / Q000187:drug effects*; D008247:Lysosomes / Q000187:drug effects*; D008297:Male; D008928:Mitochondria / Q000187:drug effects*; D008929:Mitochondria, Heart / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects; D010480:Perhexiline / Q000031:analogs & derivatives / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D010880:Piperidines; D000118:Acetylglucosaminidase; C023470:perhexiline maleate; D010480:Perhexiline