title: Effects of tension and transmural stimulation on prostaglandin production by estrous rabbit oviductal isthmus.
abstract: The effect of longitudinal and circular stretch on the amounts of Prostaglandin F (PGF) and Prostaglandin E (PGE) found in the fluid bathing rabbit oviductal isthmus has been investigated. It was found that the amounts of PGE and PGF measured in the bathing fluid of longitudinally or circularly stretched tissues were negatively correlated to the maturity of the animal. Prostaglandin E increased with time in the tissues under longitudinal and circular tension. Prostaglandin F also increased with time under longitudinal tension but remained fairly constant under circular tension. Increasing the load from 0.5 to 2.0 g had no significant effect on PGE found under longitudinal or circular tension or on PGF found under longitudinal tension. Under circular tension, PGF found increased. Transmural stimulation at 20 Hz increased PGE 8-fold over control values while PGF increased only 1 to 3-fold. It is suggested that distension of the rabbit oviductal isthmus results in increased PGF production, which could be important in ovum transport.
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D004971:Estrus; D005187:Fallopian Tubes / Q000378:metabolism* / Q000502:physiology; D005260:Female; D066298:In Vitro Techniques; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000502:physiology; D011247:Pregnancy; D011453:Prostaglandins / Q000096:biosynthesis*; D011458:Prostaglandins E / Q000096:biosynthesis; D011460:Prostaglandins F / Q000096:biosynthesis; D011817:Rabbits
chemical_list: D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F