title: Preliminary therapeutic and localization studies with human chorionic gonadotrophin.
abstract: Studies in both patients and mice have been carried out using heterologous antibody directed at secreted products of tumors. In preliminary therapeutic studies in patients with drug-resistant choriocarcinoma and malignant teratoma, heterologous anti-human chorionic gonadotrophin (HCG) and anti-alpha-fetoprotein have been combined with continued cytotoxic chemotherapy. The results to date, although interesting, are inconclusive. In nude mice, anti-HCG administration at the time of inoculation with choriocarcinoma cells failed to inhibit tumor growth. 131I-Labeled anti-HCG and anti-carcinoembryonic antigen have been used in localization studies. Specific:nonspecific ratios of up to 2:1 were obtained in human and murine studies with HCG- and carcinoembryonic antigen-producing tumors.
mesh_terms: D000818:Animals; D000906:Antibodies / Q000008:administration & dosage*; D000918:Antibody Specificity; D002272:Carcinoembryonic Antigen / Q000276:immunology; D002822:Choriocarcinoma / Q000276:immunology / Q000628:therapy*; D006063:Chorionic Gonadotropin / Q000276:immunology*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007553:Isotope Labeling; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000276:immunology / Q000628:therapy; D011247:Pregnancy
chemical_list: D000906:Antibodies; D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin