Pharmacokinetics of bromhexine in the dog.
Bromhexine hydrochloride was administered to dogs i.v. and p.o. Plasma determinations of the unchanged drug were carried out by gas-liquid chromatography with electron-capture detection. The plasma levels obtained after i.v. administration were consistent with a two-compartment open model. Comparison of the results of i.v. and oral administration show a low bioavailability, probably due to a first pass effect.
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D001964:Bromhexine / Q000008:administration & dosage / Q000378:metabolism*; D004285:Dogs; D007275:Injections, Intravenous; D007700:Kinetics
D001964:Bromhexine