title: Influence of carbocromen on some metabolic parameters of isolated working guinea pig hearts.
abstract: The influence of carbocromen (chromonar) on both functional and some metabolic parameters of isolated guinea pig hearts was tested over a broad concentration range and with different exogenous substrates. As revealed from a shift of the myocardial respiratory quotient, carbocromen (in the upper coronary active concentration range) induced an increased glucose utilization at the expense of FFA oxidation. Theoretically, this may indicate a relative reduction of myocardial oxygen demand, but the therapeutic relevance of this observation still remains obscure, as an additional exogenous FFA supply may override this biochemical carbocromen effect.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002866:Chromonar / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects; D003374:Coumarins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism / Q000187:drug effects*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006168:Guinea Pigs; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D003374:Coumarins; D005230:Fatty Acids, Nonesterified; D002866:Chromonar