Possible defect in xenobiotic activation before glycine conjugation in protein-energy malnutrition.
1. [14C]Benzoic acid administered to rats fed a normal diet was excreted mainly (99% of 24h excretion) as hippuric acid. 2. In protein-energy malnourished rats, only about 74% of [14C]benzoic acid administered was excreted as hippuric acid. The remainder was excreted as the glucuronide conjugate. 3. The oxidative phosphorylation capacity of liver mitochondria of malnourished rats was 30% less than that of normal rat liver mitochondria. 4. The decreased rate in oxidative phosphorylation is discussed in relationship to the observed decrease in glycine conjugation.
D000818:Animals; D001565:Benzoates / Q000378:metabolism / Q000652:urine; D019817:Benzoic Acid; D005965:Glucuronates / Q000652:urine; D005998:Glycine / Q000378:metabolism*; D006626:Hippurates / Q000652:urine; D007732:Kwashiorkor / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D010101:Oxygen Consumption; D051381:Rats; D011919:Rats, Inbred Strains
D001565:Benzoates; D005965:Glucuronates; D006626:Hippurates; C037620:benzoyl glucuronide; D019817:Benzoic Acid; C030514:hippuric acid; D005998:Glycine