[Experimental studies in animals on the nephrotoxicity of some new cephalosporin antibiotics: cefamandole, EMD 29 645, and 29 946 (author's transl)].
The cephalosporins cefamandole, EMD 29 645, and EMD 29 946 were tested for their nephrotoxicity in female albino Wistar rats (n = 120). The antibiotics were administered i.m. over a course of 5 days; dosage interval 12 h, dosages 1000, 2000, 3000, and 5000 mg/kg per day, respectively. For comparative evaluation of nephrotoxicity, the urinary excretion of tubular cells and enzymes (MDH, GOT, LDH) were taken. Additionally serum urea and urine protein (qualitatively) were determined. Furthermore the kidneys were investigated histologically. These experiments revealed the following tubulotoxic threshold doses: cefamandole: 3000 mg/kg per day, EMD 29 645: 2000 mg/kg per day, and EMD 29 946: 5000 mg/kg per day. EMD 29 645 was also found to be glomerulotoxic at higher doses.
D000818:Animals; D001806:Blood Urea Nitrogen; D002435:Cefamandole / Q000633:toxicity; D002511:Cephalosporins / Q000633:toxicity*; D004798:Enzymes / Q000652:urine; D005260:Female; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D007684:Kidney Tubules / Q000187:drug effects; D011507:Proteinuria / Q000139:chemically induced; D051381:Rats; D013997:Time Factors
D002511:Cephalosporins; D004798:Enzymes; D002435:Cefamandole; C016870:EMD 29645; C016872:EMD 29946
Tierexperimentelle Untersuchungen zur Nephrotoxizität neuer Cephalosporin-Antibiotika: Cefamandol, EMD 29 645 und EMD 29 946.