Effects of methylmercury and selenite on osmolarity and electrolytes in blood of mice.
Female IVCS mice were fed methylmercury at a low dose (10 nmol/g feed) with each of the doses of selenite (0, 8, 20 and 50 nmol/ml of drinking water) for 2 weeks. Mice fed methylmercury alone showed increased osmolarity of plasma: coadministration of selenite produced no change even at the lowest dose. Selenite alone did not change the osmolarity. Both concentrations of Na+ and total protein in plasma increased due to administration of methylmercury alone without change of K+ and Cl- levels. Coadministered selenite abolished this effect of methylmercury on the electrolytes and total protein of plasma.
D000818:Animals; D001769:Blood / Q000187:drug effects*; D001798:Blood Proteins / Q000378:metabolism; D002712:Chlorides / Q000097:blood; D004573:Electrolytes / Q000097:blood*; D005260:Female; D008767:Methylmercury Compounds / Q000494:pharmacology*; D051379:Mice; D009994:Osmolar Concentration; D011188:Potassium / Q000097:blood; D020887:Selenious Acid; D012643:Selenium / Q000494:pharmacology*; D012964:Sodium / Q000097:blood
D001798:Blood Proteins; D002712:Chlorides; D004573:Electrolytes; D008767:Methylmercury Compounds; D012964:Sodium; D020887:Selenious Acid; D012643:Selenium; D011188:Potassium