Synthesis of carbon-bridged pyrimidine cyclonucleosides.
6,5'-Cyclo-5'-deoxyuridine 2',3'-cyclic phosphate and its derivatives were prepared as the conformationally fixed substrates of pancreatic ribonuclease. 6,6'-Cyclouridine, 6,3'-methylene-cyclo-2', 3'-dideoxyuridine, and 6,2'-ethylene-cyclo-2'-dexoyuridine were prepared as the new types of C-cyclopyrimidine nucleosides fixed in the anti conformation. The relationship between the sign and magnitude of CD Cotton bands and glycosylic torsion angles is discussed.
D000818:Animals; D007202:Indicators and Reagents; D009712:Nucleotides, Cyclic / Q000138:chemical synthesis*; D010179:Pancreas / Q000201:enzymology; D011742:Pyrimidine Nucleotides / Q000138:chemical synthesis*; D012260:Ribonucleases; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; D009712:Nucleotides, Cyclic; D011742:Pyrimidine Nucleotides; D012260:Ribonucleases