Acetaldehyde acutely impairs canine testicular testosterone secretion.
Utilizing a method for perfusion of the in vivo isolated canine testis we have examined basal and human chorionic gonadotropin (hGC)-stimulated testosterone production of testes acutely exposed to ethanol and acetaldehyde. Ethanol infused at concentrations of 0.2 g/dl to 0.6 g/dl did not alter basal of hCG-stimulated testicular testosterone production of one testis when compared to the saline-infused control testis of the same animal. However, acetaldehyde infused at a concentration of 0.2 mg/dkl, a level similar to that found in humans drinking moderate amounts of ethanol, significantly impaired hCG-stimulated testicular testosterone production. It is concluded that acetaldehyde acutely impairs hCG-stimulated testicular testosterone secretion by a direct effect on the testis, but ethanol does not.
D000079:Acetaldehyde / Q000494:pharmacology*; D000437:Alcoholism / Q000503:physiopathology; D000818:Animals; D006063:Chorionic Gonadotropin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004195:Disease Models, Animal; D004285:Dogs; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D012636:Secretory Rate / Q000187:drug effects; D013737:Testis / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
D006063:Chorionic Gonadotropin; D000431:Ethanol; D013739:Testosterone; D000079:Acetaldehyde