Time-dependency of neurohypophyseal peptide attenuation of puromycin amnesia in mice.
[Ile3, Arg8]vasopressin (arginine-vasotocin), as well as the C-terminal tripeptides of the neurohypophyseal hormones arginine and lysine vasopressin, Pro-Arg-Gly-NH2 and Pro-Lys-Gly-NH2, were protective against puromycin-induced amnesia in mice when administered 24h before training. The N-protected tripeptide derivative, Z-Pro-Lys-Gly-NH2, was effective when given 5 days before training. The effectiveness of all peptides to attenuate puromycin-induced amnesia decreased as the interval between training and peptide treatment increased, indicating that the peptides influence memory processes, rather than general arousal. Z-Pro-Lys-Gly-NH2 was active at 24h after training, when the other peptides were no longer effective. Although it seems clear that neurohypophyseal hormones per se can attenuate puromycin-induced amnesia, these results are in line with the possibility that some portion of hormone action may be mediated via formation of longer-lived hormone fragments in the CNS.
D000647:Amnesia / Q000139:chemically induced*; D000818:Animals; D001120:Arginine / Q000494:pharmacology; D001127:Arginine Vasopressin / Q000494:pharmacology; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D008568:Memory / Q000187:drug effects*; D051379:Mice; D009481:Neurophysins / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology; D011691:Puromycin; D013997:Time Factors; D014667:Vasopressins / Q000494:pharmacology
D009481:Neurophysins; D009842:Oligopeptides; D014667:Vasopressins; D001127:Arginine Vasopressin; C029464:prolyl-arginyl-glycinamide; D011691:Puromycin; C029463:prolyl-lysyl-glycinamide; D001120:Arginine