title: Interaction of chlorpromazine with the transport system of glucose in human erythrocytes.
abstract: The characteristics of inhibition of the glucose uptake in human erythrocytes by chlorpromazine (CPZ) was investigated. It was found that CPZ is a strong inhibitor. The inhibition kinetics indicates that also two molecules of CPZ can bind to the transport system and so from two different CPZ-complexes. The dissociation constants of both the CPZ-complexes and the pH- and temperature-dependence of the inhibition were estimated.
mesh_terms: D001692:Biological Transport / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism*; D002746:Chlorpromazine / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007700:Kinetics; D013696:Temperature
chemical_list: D001786:Blood Glucose; D002746:Chlorpromazine