Acid-labile resin linkage agents for use in solid phase peptide synthesis.
Details are given of the preparation of two acid-labile peptide-resin linkage agents for use in solid phase peptide synthesis, viz. 4-hydroxymethylphenoxy-acetic acid and 3-methoxy-4-hydroxymethylphenoxyacetic acid. The latter is suitable for the preparation of peptide fragments bearing t-butyl-based side chain protecting groups.
D006016:Glycolates; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D010446:Peptide Fragments / Q000138:chemical synthesis; D010455:Peptides / Q000138:chemical synthesis*
D006016:Glycolates; D007202:Indicators and Reagents; D010446:Peptide Fragments; D010455:Peptides; C036786:4-hydroxymethylphenoxyacetic acid; C036787:3-methoxy-4-hydroxymethylphenoxyacetic acid