[Effect of stimulation and destruction of the substantia nigra on phenamine- and apomorphine-induced stereotypy in cats].
Electrical stimulation of substantia nigra enhances the behavioral and electroencephalographic parameters of the stereotypy induced by threshold doses of amphetamine (0.5 and 1 mg/kg) but does not produce any effect on apomorphine action (2 and 5 mg/kg). Bilateral electrolytic destruction of the brain structure, on the contrary, reduces the action of amphetamine, especially in the early postoperative period. At the same time the intensity of the apomorphine-induced stereotypy rises. It is concluded that the increased activity of substantia nigra is of crucial significance in the genesis of the amphetamine-induced stereotypy. Meanwhile the effect of apomorphine may be realized without direct participation of the brain structure under consideration.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D002415:Cats; D005260:Female; D006801:Humans; D008297:Male; D013239:Stereotyped Behavior / Q000187:drug effects / Q000502:physiology*; D013378:Substantia Nigra / Q000502:physiology*
D000661:Amphetamine; D001058:Apomorphine
Vliianie stimuliatsii i razrusheniia chernoĭ substantsii na fenaminovuiu i apomorfinovuiu sterotipiiu u koshek.