title: [Treatment of mania by a calcium inhibitor. Preliminary study].
abstract: The authors are studying the effects on pure manic syndromes of reduction of intracytoplasmic ionised calcium through administration of a calcic inhibitor. Three wellknown bipolar patients (manic type) were significantly improved. One patient was quickly cured, but in this case (first access in a young man) spontaneous remission cannot be excluded. One patient was not improved, and presented a secondary manic state, related to a beginning cerebrary involution. These results, if confirmed, would orient future research in primary manic syndromes and in mode of action of lithium on calcic metabolism.
mesh_terms: D000328:Adult; D000341:Affective Disorders, Psychotic / Q000188:drug therapy*; D001552:Benzazepines / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy*; D004110:Diltiazem / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013577:Syndrome
chemical_list: D001552:Benzazepines; D004110:Diltiazem
vernacular_title: Traitement de la manie par un inhibiteur calcique. Etude préliminaire.