Is the diurnal increase of fibrinolytic activity influenced by alpha- or beta-adrenergic blockade?
The diurnal increase of fibrinolytic activity in the forenoon was investigated after alpha- and beta-adrenergic blockade in 15 volunteers. Four milligrams propranolol was injected i. v. alone or in combination with 20 mg phentolamine. Neither the beta-blocking agent, propranolol, nor the combination with the alpha-blocker, phentolamine, had any significant effect on the diurnal increase of fibrinolytic activity.
D002940:Circadian Rhythm / Q000187:drug effects*; D004347:Drug Interactions; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D010646:Phentolamine / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*
D011433:Propranolol; D010646:Phentolamine