title: Metabolism of methyl methacrylate: evidence for metabolism by the valine pathway of catabolism in rat and in man.
abstract: 1. Evidence to support the suggestion that methyl methacrylate is metabolized by the normal pathway of valine catabolism has been obtained by the administration of methyl [Me-14C]methacrylate to rats. 2. Of the administered dose, 80% was respired as 14CO2 as predicted, and methylmalonic acid, specifically labelled with 14C in a manner consistent with the proposed pathway of metabolism, was excreted (0.22%) dose). 3. Following administration of sodium [Me-2H3]methacrylate to a human subject, [Me-2H3]methylmalonic acid was detected in the urine by g.l.c.-mass spectrometry.
mesh_terms: D000818:Animals; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008764:Methylmalonic Acid / Q000652:urine; D020366:Methylmethacrylate; D008768:Methylmethacrylates / Q000378:metabolism*; D051381:Rats; D013045:Species Specificity; D014633:Valine / Q000378:metabolism*
chemical_list: D008768:Methylmethacrylates; D020366:Methylmethacrylate; D008764:Methylmalonic Acid; D014633:Valine