title: Mechanically induced tube damage in the artificial hydrosalpinx.
abstract: One-sided artificial hydrosalpinx was caused in mature New Zealand rabbits by proximal and distal ligature. After 2 weeks the average secretion accumulation was 2.1 ml, after 8 weeks 6.3 ml. A fold relief could no longer be detected after 8 weeks. The light-microscopical study of the epithelium showed signs of cell degeneration with cell dedifferentiation, pyknosis of the nucleus, and perinuclear aerolae. The ciliation of 66% ciliated cells for the normal oviduct (pars ampullaris) was reduced to 15% after 8 weeks of artificial hydrosalpinx. Based on the hypertrophy of the muscularis the percentage loss of E2 receptors within 4 weeks was smaller in comparison with the percentage reduction of the ciliation during the same time. Finally, after 8 weeks an amount of 15% for the estrogen receptors as well as for the ciliation was achieved--both compared to the untreated oviduct. It is possible that the oviduct damage, caused only by the mechanical influence of the secretion congestion, is the reason for the unfavorable pregnancy rate after salpingoneostomy of a chronic atrophied hydrosalpinx.
mesh_terms: D000818:Animals; D005184:Fallopian Tube Diseases / Q000473:pathology*; D005187:Fallopian Tubes / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D011183:Postoperative Complications; D011247:Pregnancy; D011817:Rabbits; D011960:Receptors, Estrogen / Q000032:analysis; D012488:Salpingitis / Q000601:surgery
chemical_list: D011960:Receptors, Estrogen