The distribution of erythropoiesis over the various anatomical regions of the erythropoietic system in some inbred strains of mice.
The extraction of 59Fe bound to the heme in the erythropoietic organs by means of acid ethylacetate was used to establish the proportion of erythropoiesis for which individual bones and the spleens of some inbred mouse strains are responsible. The proportion of splenic erythropoiesis differs from strain to strain, being in the range 9-42% of total erythropoiesis. In the strain BALB/c erythropoiesis is shifted in comparison with C57B1/10 strain towards the spine and away from the bones of the skull, the long bones of the limbs and the pelvis. Calculations of the erythroid cellularity and/or the intensity of erythropoiesis of the total bone marrow on the basis of a single bone should take into account both these interstrain differences in the participation of different regions and the possibility of various proportions of red and white blood cells and cells containing non-heme iron existing in different regions (bones).
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism / Q000502:physiology*; D001854:Bone Marrow Cells; D004920:Erythropoiesis; D005260:Female; D006418:Heme / Q000378:metabolism; D007504:Iron Radioisotopes; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010384:Pelvic Bones / Q000502:physiology; D012886:Skull / Q000502:physiology; D013045:Species Specificity; D013131:Spine / Q000502:physiology; D013154:Spleen / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D013997:Time Factors
D007504:Iron Radioisotopes; D006418:Heme