title: Pharmacokinetic studies of amoxicillin, potassium clavulanate and their combination.
abstract: Pharmacokinetic parameters after oral administration of 500 mg amoxicillin, 125 mg potassium clavulanate and 625 mg of their combination (augmentin) were determined in a randomized crossover study in ten healthy volunteers. The absolute bioavailability of amoxicillin (AUCoral/AUCi.v.) was 0.70 +/- 0.12. The mean maximum serum concentration of amoxicillin was 6.5 +/- 1.6 mg/l after administration alone and 6.5 +/- 1.4 mg/l after administration in combination. The respective values for potassium clavulanate were 3.4 +/- 1.4 mg/l and 2.8 +/- 1.1 mg/l. With both substances there was no significant difference between the pharmacokinetic parameters after administration alone and in combination. The AUC for amoxicillin was 19.5 +/- 5.4 h x mg/l after administration alone and 23.2 +/- 10.6 h x mg/l after administration in combination. The respective value for potassium clavulanate were 7.8 +/- 3.2 h x mg/l and 7.3 +/- 2.0 h x mg/l.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage / Q000378:metabolism*; D019980:Amoxicillin-Potassium Clavulanate Combination; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D002969:Clavulanic Acids / Q000008:administration & dosage / Q000378:metabolism*; D004338:Drug Combinations / Q000008:administration & dosage / Q000378:metabolism; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D004338:Drug Combinations; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin