Properties of rotational behaviour produced by methylxanthine derivatives in mice with unilateral striatal 6-hydroxydopamine-induced lesions.
The present investigation was undertaken to study effects of methylxanthine derivatives on rotational behaviour produced by dopamine receptor stimulating drugs and properties of methylxanthine-induced rotation in mice with unilateral 6-hydroxydopamine (6-OHDA)-induced lesions of the striatum. L-Dopa 10mg/kg, i.p., produced contralateral turning which lasted for about 40 min. When L-dopa 10mg/kg was given to mice in combination with theophylline 25 mg/kg, total turns for 2 hr were significantly higher than those of L-dopa and theophylline alone. Caffeine and theophylline in doses of 25 and 50 mg/kg, i.p., respectively, produced marked increase in contralateral rotation in a dose-dependent manner in mice with lesions. Theobromine 100 mg/kg, i.p., also produced a moderate contralateral rotation. Total turns of ipsilateral rotation produced by methylxanthine derivatives were less than 10% of those of contralateral circling. Theophylline-induced contralateral rotation was reduced to nearly 30% of the control by alpha-methyl-p-tyrosine (alpha-MPT). It was also suppressed by spiroperidol, at a dose higher than that to apomorphine or methamphetamine. These results suggest that methylxanthine derivatives produce contralateral rotational behaviour due to not only phosphodiesterase inhibition but also dopamine receptor stimulation.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003342:Corpus Striatum / Q000502:physiology*; D006801:Humans; D006892:Hydroxydopamines / Q000494:pharmacology*; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D051379:Mice; D011954:Receptors, Dopamine / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects*; D013806:Theophylline / Q000494:pharmacology; D013997:Time Factors; D014970:Xanthines / Q000494:pharmacology*
D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D014970:Xanthines; D007980:Levodopa; D013806:Theophylline; D001058:Apomorphine