Cholinergic agonist-induced down regulation of neuronal alpha-bungarotoxin receptors.
The ability of cholinergic ligands to regulate neuronal alpha-bungarotoxin receptor number was studied in dissociated monolayer cultures of embryonic chick ciliary ganglion neurons. Carbamylcholine and nicotine, but not D-tubocurarine, caused a loss of 25% of the surface [125I]alpha-bungarotoxin receptors within 1 h at 37 degrees C. This receptor loss occurred without change in affinity for [125I]alpha-bungarotoxin, was temperature-sensitive and was prevented by co-incubation with D-tubocurarine.
D000818:Animals; D002038:Bungarotoxins / Q000378:metabolism; D002217:Carbachol / Q000494:pharmacology*; D002642:Chick Embryo; D005726:Ganglia, Parasympathetic / Q000187:drug effects* / Q000378:metabolism; D007700:Kinetics; D009538:Nicotine / Q000494:pharmacology*; D011950:Receptors, Cholinergic / Q000187:drug effects* / Q000378:metabolism; D011978:Receptors, Nicotinic; D014403:Tubocurarine / Q000494:pharmacology; D064569:alpha7 Nicotinic Acetylcholine Receptor
D002038:Bungarotoxins; D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic; D064569:alpha7 Nicotinic Acetylcholine Receptor; D009538:Nicotine; D002217:Carbachol; D014403:Tubocurarine