Interaction of chlorpromazine with the transport system of glucose in human erythrocytes.
The characteristics of inhibition of the glucose uptake in human erythrocytes by chlorpromazine (CPZ) was investigated. It was found that CPZ is a strong inhibitor. The inhibition kinetics indicates that also two molecules of CPZ can bind to the transport system and so from two different CPZ-complexes. The dissociation constants of both the CPZ-complexes and the pH- and temperature-dependence of the inhibition were estimated.
D001692:Biological Transport / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism*; D002746:Chlorpromazine / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007700:Kinetics; D013696:Temperature
D001786:Blood Glucose; D002746:Chlorpromazine