Glucocorticoid receptors in human tumors.
Glucocorticoid receptors were examined in a range of solid human tumors. In addition to breast carcinomas, subsets of other tumor types (notably renal cell carcinomas) contain concentrations of these receptors characteristic of glucocorticoid-responsive tissues. The physico-chemical properties of the single glucocorticoid receptor present in the human tumors resembled those of the glucocorticoid receptor in rat tumors and the predominant form found in normal target tissues of the rat.
D000818:Animals; D002277:Carcinoma / Q000032:analysis / Q000378:metabolism; D003110:Colonic Neoplasms / Q000032:analysis; D003907:Dexamethasone; D006801:Humans; D007680:Kidney Neoplasms / Q000032:analysis / Q000378:metabolism; D007700:Kinetics; D008114:Liver Neoplasms, Experimental / Q000032:analysis; D008175:Lung Neoplasms / Q000032:analysis; D009369:Neoplasms / Q000032:analysis*; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000032:analysis* / Q000378:metabolism; D011987:Receptors, Steroid / Q000032:analysis*; D012509:Sarcoma / Q000032:analysis
D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D003907:Dexamethasone