Vaccination of seronegative high-risk populations with attenuated rubella vaccine.
A total of 590 young females were screened for rubella antibodies. About 10% were seronegative, the frequency being lowest in vaccinated school girls. No coincidence between rubella and mumps seronegativity was observed. Forty-nine seronegative persons were vaccinated and 67 seropositive persons were vaccinated as controls. Vaccination resulted in a clearcut, albeit slow, IgG-response, and IgM-response in most and no IgA-response. Side effects were observed in both groups but a rubella-like minor illness was seen in seronegatives only. Careful screening of rubella antibody status in high risk groups such as female medical and nursing students is emphasized.
D000293:Adolescent; D000328:Adult; D000917:Antibody Formation; D002648:Child; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D012409:Rubella / Q000175:diagnosis / Q000276:immunology / Q000517:prevention & control*; D012411:Rubella Vaccine / Q000009:adverse effects / Q000627:therapeutic use*; D012698:Serologic Tests; D014613:Vaccines, Attenuated / Q000627:therapeutic use*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012411:Rubella Vaccine; D014613:Vaccines, Attenuated