Effect of arginine thiazolidinecarboxylate on allyl alcohol hepatotoxicity in the rat.
The effect of arginine thiazolidinecarboxylate on allyl alcohol hepatotoxicity in the rat was studied. Serum glutamic oxalacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and serum alkaline phosphatase (SAP) levels were estimated and gross and microscopic studies of the liver were performed. Plasma and liver concentrations of thiazolidinecarboxylic acid were determined after arginine thiazolidinecarboxylate oral treatment in rats. The compound rapidly absorbed and taken up by the liver was very effective in protecting against allyl alcohol hepatotoxicity, as it reduced extensive liver necrosis and high serum enzyme levels.
D000433:1-Propanol / Q000037:antagonists & inhibitors / Q000633:toxicity; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001120:Arginine / Q000378:metabolism / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000517:prevention & control*; D007700:Kinetics; D020005:Propanols; D051381:Rats; D013844:Thiazoles / Q000378:metabolism / Q000494:pharmacology*; D053778:Thiazolidines
D020005:Propanols; D013844:Thiazoles; D053778:Thiazolidines; C006463:allyl alcohol; C020213:arginine thiazolidinecarboxylate; D001120:Arginine; D000433:1-Propanol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase