Coagulation changes during management of fetal death with 15(s)-15-methylprostaglandin F2 alpha.
Changes in the coagulation mechanism were studied during and after 15(S)-15-methylprostaglandin F2 alpha (15-me-PGF2 alpha) administration for termination of pregnancy because of intrauterine fetal death after 20 wk pregnancy. 12 patients, of whom 2 were under and 6 over 28 wk, were studied. 2-Hourly intramuscular administration of 250 microgram 15-me-PGF2 alpha resulted in expulsion in a median time of 9 h (range: 2-24.3 h). Although the drug may have some inhibitory effect on platelet aggregation, its influence on coagulation and the hemostatic mechanism was negligible.
D000028:Abortion, Induced; D001777:Blood Coagulation / Q000187:drug effects*; D002260:Carboprost / Q000494:pharmacology*; D005260:Female; D005313:Fetal Death; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D011247:Pregnancy; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*
D011461:Prostaglandins F, Synthetic; D002260:Carboprost