Evidence for an unusual multifunctional protoreceptor in hormone action.
Contrary to the techniques of mere association, column chromatography has revealed a 'protoreceptor' that accepts aldosterone agonists and antagonists only in the physiological target, the kidney, and is absent in non-targets, liver and serum; it is furthermore different from the aldosterone specific receptor in renal cytosol.
D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D002848:Chromatography, DEAE-Cellulose; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D000451:Mineralocorticoid Receptor Antagonists / Q000378:metabolism*; D009649:Norpregnadienes / Q000378:metabolism*; D011374:Progesterone / Q000378:metabolism*; D011397:Promegestone / Q000378:metabolism*; D051381:Rats; D011987:Receptors, Steroid / Q000378:metabolism*
D000451:Mineralocorticoid Receptor Antagonists; D009649:Norpregnadienes; D011987:Receptors, Steroid; D000450:Aldosterone; D011374:Progesterone; D011397:Promegestone