Studies on Dipetalonema viteae (Filarioidea). 5. Ultrastructural aspects of the antibody-dependent cell-mediated destruction of microfilariae.
The antibody-dependent cell-mediated destruction of Dipetalonema viteae microfilariae was followed by electron microscopy both in vitro and within micropore chambers in vivo. There was a correlation between the degree of adherence (1% mf with adhered cells) and the degree of microfilarial damage. Polymorphonuclear leukocytes, predominantly neutrophils, seemed to be responsible for the destruction of microfilariae in vivo. An in vitro assay indicated that eosinophils also have a role as potent effectors against microfilariae. The first sign of microfilarial damage is the disintegration of cuticular layers. In a later stage of destruction, lysis of the hypodermis or even of the whole microfilarial tissues was observed.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D006224:Cricetinae; D004153:Dipetalonema / Q000276:immunology / Q000648:ultrastructure*; D004804:Eosinophils / Q000502:physiology; D005260:Female; D007962:Leukocytes / Q000502:physiology; D008647:Mesocricetus; D051379:Mice; D008813:Mice, Inbred ICR; D008842:Microfilariae / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure; D008854:Microscopy, Electron