title: Antidepressant drugs: side effects and compliance.
abstract: Despite controversy about the significance of compliance, the difficulty of studying the issue, and the poor quality of research in this area, there is a consensus from the literature and patient self-reports that side effects reduce compliance. About a fifth of depressed patients refuse drugs, and half of those in treatment drop out because of specific side effects and/or general attitudes toward treatment. Strategies to decrease side effects and improve compliance include plasma monitoring, once-a-day regimens, educational techniques, and basing the choice of tricyclic compounds or second generation drugs on individual patient needs.
mesh_terms: D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects / Q000627:therapeutic use; D001294:Attitude to Health; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D010349:Patient Compliance; D010353:Patient Education as Topic
chemical_list: D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic