title: Induction of ovulation by combined clomiphene citrate and dexamethasone treatment in clomiphene citrate nonresponders.
abstract: Fifteen anovulatory, oligomenorrheic, hyperandrogenic and normoprolactinemic women who failed to respond to prolonged clomiphene citrate (CC) treatment, were subsequently treated with CC and small doses of dexamethasone (Dex). Twelve (80%) of the patients ovulated according to BBT and progesterone values, and 7 (49%) conceived during 3--6 treatment cycles. Five of these pregnancies terminated in live, single, full term deliveries, one set of twins and one first trimester abortion. It is concluded that a regimen of combined CC and a small dose of Dex may be offered to CC nonresponders as an effective alternative to Menotropins--HCG treatment.
mesh_terms: D000328:Adult; D000728:Androgens / Q000502:physiology; D000858:Anovulation / Q000188:drug therapy; D002996:Clomiphene / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use*; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D045166:Estradiol Congeners / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy; D009839:Oligomenorrhea / Q000188:drug therapy; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy
chemical_list: D000728:Androgens; D045166:Estradiol Congeners; D002996:Clomiphene; D003907:Dexamethasone