[Experimental evaluation of toxicity of selected mixtures used in metallurgy].
The investigation is aimed at evaluation of the effects of copper-coating and bonderizing solutions and oil--emulsion used in technological processes in the metallurgic industry upon hematological and biochemical changes in rats' peripheral blood. The studies were performed on male Wistar rats. The solutions were carried onto hairy and depilated skin. Acute toxicity was evaluated in two-weeks' experiment and chronic toxicity in three--months' experiment. The copper-coating solution was found to be most hazardous, whereas the oil emulsion-the least hazardous. The copper-coating and bonderizing solutions, when chronically applied, result in anaemia and changes in the percentage picture of leucocytes, and also increased blood concentration of uric acid, creatinine and hydroxyproline. No significant changes in concentrations of the remaining biochemical indices were found. The results point to synergistic effects of oil-emulsion and copper-coating solution.
D000818:Animals; D001772:Blood Cell Count; D001773:Blood Cells / Q000473:pathology; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D004655:Emulsions; D006454:Hemoglobins / Q000032:analysis; D006909:Hydroxyproline / Q000378:metabolism; D007668:Kidney / Q000503:physiopathology; D007677:Kidney Function Tests; D008297:Male; D008669:Metallurgy; D009821:Oils / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D014116:Toxicology; D014675:Vegetables
D004338:Drug Combinations; D004655:Emulsions; D006454:Hemoglobins; D009821:Oils; D006909:Hydroxyproline
Doświadczalna ocena toksyczności wybranych mieszanin uzywanych w przemyśle hutniczym.