[On the metabolism of eprazinone (author's transl)].
After oral application of 3-[4-(beta-ethoxyphenethyl)-1-piperazinyl]-2-methylpropiophenone dihydrochloride (eprazinone, Eftapan) together with the unchanged drug, five degradation products were detected and subsequently identified by gas liquid chromatography/mass spectrometry in human urine. With respect to the presented results, eprazinone is degraded by various routes in man: 1. hydrolysis which leads to metabolites M1 and M4, and  2.  cleavage of alpha-binding to the nitrogen atom and successive dealkylation reactions resulting in M2, M3 and M5, respectively.
D000996:Antitussive Agents / Q000378:metabolism*; D001711:Biotransformation; D002854:Chromatography, Paper; D002855:Chromatography, Thin Layer; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D010879:Piperazines / Q000378:metabolism*; D011427:Propiophenones / Q000378:metabolism*
D000996:Antitussive Agents; D010879:Piperazines; D011427:Propiophenones; C007608:eprazinone
Zum Metabolismus von Eprazinon.