The use of N,N-diethyl-m-toluamide to enhance dermal and transdermal delivery of drugs.
A dermal penetration enhancer has been found which improves the dermal delivery of a wide variety of drugs and at the same time has a history of low toxicity for human dermal application. N,N-Diethyl-m-toluamide (I) has been shown to improve the delivery of many drugs through hairless mouse skin in an in vitro diffusion cell model. A topically applied steroid, hydrocortisone, has been used to demonstrate the in vivo effectiveness of I on human skin. The degree of pallor produced on human skin by the corticosteroids was used as a measure of the relative delivery of hydrocortisone from formulations with and without I.
D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003671:DEET / Q000494:pharmacology*; D004058:Diffusion; D005079:Excipients; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D051379:Mice; D008812:Mice, Hairless; D009824:Ointments; D012869:Skin Absorption / Q000187:drug effects*; D013997:Time Factors
D001549:Benzamides; D005079:Excipients; D009824:Ointments; D003671:DEET; D006854:Hydrocortisone