[Distribution of adriamycin in the gastric cancer, gastric wall and regional lymph nodes after a regional arterial infusion].
As a fundamental investigation to prevent from the postoperative recurrence of gastric cancer, the concentrations of adriamycin(ADM) in the gastric tumor, gastric wall and regional nodes were measured after an arterial infusion of 5 or 10 mg of ADM. The drug was infused through either left or right gastric artery or the right gastroepiploic artery at the beginning of operation. The ADM concentration in gastric tumor and gastric wall were moderately elevated after the infusion, especially in the tissue at the area of arterial supply used for the infusion. No significant correlation was found among ADM concentration in the tumor, its histological classification and its amount of interstitial connective tissue. However, the marked elevation of ADM level was confirmed in the perigastric nodes along the drug-infused artery. The moderate elevation was also observed in the 2nd or 3rd group of the regional lymph nodes. As for the drug concentration in the adjacent organs, ADM was detected in slight high level in the liver, less in the spleen and pancreas. From the results obtained, a possibility of prevention from the recurrence of gastric cancer was discussed.
D004317:Doxorubicin / Q000008:administration & dosage / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D007261:Infusions, Intra-Arterial; D007430:Intraoperative Care; D008198:Lymph Nodes / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D014018:Tissue Distribution
D004317:Doxorubicin