Circling produced by serotonin and dopamine agonists in raphe lesioned rats: a serotonin model.
The serotonin (5-HT) receptor agonists quipazine and 5-methoxy-N,N-dimethyltryptamine caused slow, contralateral circling, which was not dose-related, when given to rats with an asymmetric electrolytic lesion of the midbrain medial raphe nucleus. No circling was recorded after administration of fenfluramine, a compound that releases 5-HT. The dopamine drugs apomorphine and d-amphetamine caused vigorous circling in raphe lesioned rats which was increased further by quipazine but antagonized by fenfluramine. The effects of the 5-HT drugs on d-amphetamine circling were closely dose-related. The results suggest that modulation of d-amphetamine circling by 5-HT agonists in rats with a specific, asymmetric 5-HT lesion could provide the basis for a 5-HT rotation model.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001933:Brain Stem / Q000502:physiology*; D003913:Dextroamphetamine / Q000494:pharmacology; D018492:Dopamine Antagonists; D005260:Female; D005277:Fenfluramine / Q000494:pharmacology; D006801:Humans; D008732:Methoxydimethyltryptamines / Q000494:pharmacology*; D011804:Quinolines / Q000494:pharmacology*; D011814:Quipazine / Q000494:pharmacology*; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D012701:Serotonin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects*
D018492:Dopamine Antagonists; D008732:Methoxydimethyltryptamines; D011804:Quinolines; D005277:Fenfluramine; D012701:Serotonin; D011814:Quipazine; D001058:Apomorphine; D003913:Dextroamphetamine