Iron deficiency-induced circadian rhythm reversal of dopaminergic-mediated behaviours and thermoregulation in rats.
An iron-free diet for 28 days caused a reduced level of iron in the blood. Iron deficient rats exhibited a lower level of motor activity and reversed circadian rhythms of thermoregulation and motor activity. The hypothermic effect of d-amphetamine was significantly reduced in iron deficient rats, and the magnitude of this effect was correlated with the decrease in the blood and brain. The hypermotility effect of d-amphetamine was also significantly reduced. Apomorphine-induced stereotyped behaviour was greater during the light period in contrast to that of control rats. The results of this study indicate that iron plays a major role in the normal function of the monoaminergic system in the brain, particularly in the dopaminergic system, via modification of dopaminergic receptors.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000502:physiology*; D001833:Body Temperature Regulation; D002940:Circadian Rhythm; D003913:Dextroamphetamine / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D006801:Humans; D000090463:Iron Deficiencies; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009638:Norepinephrine / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects
D001058:Apomorphine; D003913:Dextroamphetamine; D004298:Dopamine; D009638:Norepinephrine