[Measuring the potential difference of gastric mucosa as a means of quantifying the protective effect of Al-acetylglycyrrhetinate after a dose of acetylsalicylic acid (author's transl)].
A clinical pharmacological model to measure the potential difference of the gastric mucosa is reported. The model partially from literature derived has been further developed mathematically. An irritation index is reliable to quantify the protective function of chemical agents. In the reported study Al-acetylsalicylic acid (ASA): The measured parameters (Pdmax, AUB) show that the irritation of the gastric mucosa induced by ASA can be reduced if 100 mg Al-acetylglycyrrhetinate has been predosed. After the instillation of 1000 mg ASA the mean Pdmax amounts to 27.20 [mV] (s = 9.63), the AUB to 930.60 [mV . mins] (s = 311.10). After pre-treatment with Al-acetylglycyrrhetinate the irritation of ASA only produces a Pdmax of 17.80 [mV] (s = 986) and and AUB of 678.60 [mV . min] (s = 374.11). The differences of Pdmax and AUB are significant on the 5% level. The irritation index for 1000 mg ASA amounts to 27.5 [mV2 . min], after pre-treatment with 100 mg Al-acetylglycyrrhetinate it decrease to 14.9 [mV2 . min].
D000328:Adult; D001241:Aspirin / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D011292:Premedication
C013384:acetylglycyrrhetinic acid; D006034:Glycyrrhetinic Acid; D001241:Aspirin
Messung der Potentialdifferenz der Magenmucosa als Möglichkeit zur Quantifizierung des Schutzeffektes von Al-Acetylglycyrrhetinat nach Gabe von Acetylsalicylsäure.