Syngeneic tumor immunizations produce Qa antibodies. Discovery of a new Qa antigen, Qa-6.
BALB/cBy (Qa-2-) mice injected with the syngeneic tumor, ORA I-a (Qa-2+), produced antibodies to Qa-2 and a newly discovered antigen, Qa-6. Specific antisera against Qa-6, in the presence of complement, lyses approximately 40% of lymph-node lymphocytes and splenocytes. Strain distribution analyses indicate that Qa-6 is specified by a gene within the TL subregion of the major histocompatibility complex. Thus, Qa-6 is the third member of the Qa/TL subset of cell surface antigens which is anomalously expressed on certain tumor cells. This finding suggests that the Qa and TL molecules may have a unique, functional role on the cell surface.
D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics*; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology*; D002874:Chromosome Mapping; D005796:Genes; D008040:Genetic Linkage; D006084:Graft Rejection; D015395:Histocompatibility Antigens Class I; D007518:Isoantibodies / Q000096:biosynthesis; D051379:Mice; D009368:Neoplasm Transplantation
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D015395:Histocompatibility Antigens Class I; D007518:Isoantibodies; C032907:Q surface antigens