[Stability of antilipidemic etofibrate and its metabolites towards gastrointestinal and blood hydrolases (author's transl)].
Etofibrate is preferentially cleaved in its clofibrinic acid ester group by the hydrolases of the blood. The formed nicotinic acid 2-hydroxyethyl ester is considerably more stable than the 2-(4-chlorophenoxy)-2-methylpropionic acid (2-hydroxyethyl)-ester. Against artificial gastric and intestinal juice (USP XIX), the nicotinic acid 2-hydroxyethyl ester is almost completely stable. Etofibrate is bound to plasma albumin substantially more tightly than is clofibrate.
D001711:Biotransformation; D002994:Clofibrate / Q000031:analogs & derivatives* / Q000494:pharmacology; D002995:Clofibric Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D004064:Digestive System / Q000201:enzymology*; D004355:Drug Stability; D004950:Esterases / Q000378:metabolism; D006801:Humans; D006867:Hydrolases / Q000097:blood / Q000378:metabolism*; D000960:Hypolipidemic Agents / Q000378:metabolism*; D007700:Kinetics
D000960:Hypolipidemic Agents; C009746:etofibrate; D002995:Clofibric Acid; D006867:Hydrolases; D004950:Esterases; D002994:Clofibrate
Zur Stabilität des Blutlipidsenkers Etofibrat und seiner Metabolite gegenüber Hydrolasen des Gastrointestinaltraktes und des Blutes.