title: [Adjuvant chemotherapy in the treatment of infiltrating cancers of the bladder. Preliminary results in 25 cases].
abstract: Twenty-five cases of invasive carcinoma of the bladder treated by surgery, radiotherapy and chemotherapy are discussed. Cis-diammine dichloroplatinum (CDDP) was used in 8 cases, bleomycin in perfusion in 6 cases and a combination of CDDP and adriamycin in 11 cases. Of 8 cases with lymph node invasion, 4 are alive 5 to 21 months after the start of treatment. Of 12 who were followed up and has no nodal involvement, 9 are alive 5 to 52 months from the start of treatment. The tolerance to treatment is poor, but the results are encouraging. Therefore, we suggest a program of treatment consisting of intense preoperative radiotherapy, partial or radical cystectomy, followed by an combination of 100 mg of CDDP and 60 mg of adriamycin monthly for 9 months.
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Chimiothérapie adjuvante dans le traitement des cancers infiltrants de la vessie. Résultats préliminaires sur 25 cas.