Effectiveness of clonidine in patients with angina pectoris in relation to the initial level of catecholamines in urine.
32 patients with chronic angina pectoris were given clonidine in a dose 150 microgram/day parallelly with routine coronary drugs. The aim of the study was to select the best candidates for this kind of treatment which is known to reduce sympathetic tone and consequently alleviates the severity of the disease. It has been found that clonidine produced clinical improvement predominantly in patients characterized by high initial excretion of catecholamines in urine. The beneficial effect of such treatment was parallelled by a decrease of adrenaline and noradrenaline content in urine. The results obtained have confirmed the supposition that the best candidates for clonidine therapy are individuals with highly augmented adrenergic strain.
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy* / Q000652:urine; D003000:Clonidine / Q000627:therapeutic use*; D004341:Drug Evaluation; D004837:Epinephrine / Q000652:urine*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D009638:Norepinephrine / Q000652:urine*
D003000:Clonidine; D009638:Norepinephrine; D004837:Epinephrine