Influence of pretreatment with disulfiram (DSF) on the acute toxicity of cyclophosphamide (CP) in male Sprague-Dawley rats.
Treatment with disulfiram (DSF, 1000 mg/kg p.o.) 2 or 6 h prior to s.c. injection of cyclophosphamide (CP) raised the acute toxicity of CP in male Sprague-Dawley rats by 60%. The acute LD50 was reduced from 236 mg/kg after application of CP alone to 90 mg/kg and 95 mg/kg after pretreatment with DSF 2 and 6 h prior to CP administration, respectively.
D000818:Animals; D003520:Cyclophosphamide / Q000633:toxicity*; D004221:Disulfiram / Q000494:pharmacology*; D004357:Drug Synergism; D007928:Lethal Dose 50; D008297:Male; D051381:Rats
D003520:Cyclophosphamide; D004221:Disulfiram