[Effect of triterpene glycosides and polyene antibiotics on cell membrane permeability for K+ ions and UV-absorbing substances].
The effect of triterpene glycosides (cauloside C from Caulophyllum robustum, theasaponine from Thea sinensis, cucumarioside G from Cucumaria fraudatrix stichoposide A from Stichopus japonicus S., holothurines A and B from Holothuria mexicana, holothurine C from Bohadschia sp.) on the membrane permeability for K+ ions and UV-absorbing substances was compared with that of polyene antibiotics, viz., amphotericine B and nystatine. As a biological model fertilized eggs of sea urchin Strongylocentrotus nudus and yeast Saccharomyces carlsbergensis were used. In the sea urchin study most triterpene glycosides in low concentrations induced the outflux of K+ and in hgih concentrations that of both K+ and UV-absorbing agents. In the yeast study triterpene glycosides at identical doses induced the outflux of both K+ and UV-absorbing agents. The membranotropic effect of triterpene glycosides depended on the medium temperature and the biological system used.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006027:Glycosides / Q000494:pharmacology*; D010063:Ovum / Q000187:drug effects; D011090:Polyenes / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism*; D012440:Saccharomyces / Q000187:drug effects; D012617:Sea Urchins / Q000187:drug effects; D014315:Triterpenes / Q000494:pharmacology*; D014466:Ultraviolet Rays
D000900:Anti-Bacterial Agents; D006027:Glycosides; D011090:Polyenes; D014315:Triterpenes; D011188:Potassium
Vliianie nekotorykh triterpenovykh glikozidov i polienovykh antibiotikov na pronitsaemost' kletochnykh membran dklia ionov K+ i UF-pogloshchaiushchikh veshchestv.