title: Sodium butyrate stimulates hCG and hCG-alpha production in a human choriocarcinoma cell line (BeWo).
abstract: To assess regulatory mechanism(s) of hormone production between ectopic and eutopic tumor cells, the effect of sodium butyrate on cell growth and hormone production was studied in BeWo, a trophoblastic cell line and in HeLa S3, a nontrophoblastic cell line. The addition of 2 mM sodium butyrate to HeLa S3 produced a marked increase in hCG-alpha both in the medium and in the cell extract, in contrast to its inhibitory effects on cell growth. Sodium butyrate had a similar effect on cell growth and hormone secretion in BeWo cells, as seen with an increase in release of hCG and hCG-alpha were also increased after exposure to sodium butyrate in BeWo. Thus, the regulation of hormone production in trophoblastic and nontrophoblastic tumor cells probably does not differ.
mesh_terms: D002087:Butyrates / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002822:Choriocarcinoma / Q000378:metabolism*; D006063:Chorionic Gonadotropin / Q000096:biosynthesis*; D005260:Female; D006367:HeLa Cells / Q000378:metabolism; D006801:Humans; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000378:metabolism*
chemical_list: D002087:Butyrates; D006063:Chorionic Gonadotropin