[Plasma androgens and testosterone binding globulin levels in hirsute women. Effects of dexamethasone and oestrogen-progestagen administration (author's transl)].
In a group of 19 women with idiopathic hirsutism plasma levels of testosterone binding globulin were significantly lowered, and plasma levels of total and unbound testosterone were significantly raised. After administration of dexamethasone or oestrogenprogestagen combination, the concentrations of free testosterone returned to the normal range for non hirsute women. This suggests that both the ovary and the adrenal cortex were responsible for the high plasma testosterone levels observed in these patients.
D000293:Adolescent; D000302:Adrenal Cortex / Q000378:metabolism; D000328:Adult; D000728:Androgens / Q000097:blood*; D003907:Dexamethasone / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D006628:Hirsutism / Q000097:blood* / Q000209:etiology; D006801:Humans; D008234:Lynestrenol / Q000494:pharmacology*; D010053:Ovary / Q000378:metabolism; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*; D013739:Testosterone / Q000097:blood
D000728:Androgens; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004997:Ethinyl Estradiol; D003907:Dexamethasone; D008234:Lynestrenol
Androgènes et capacité de liaison de la testostérone plasmatique chez la femme hirsute. Effets de l'administration de dexaméthasone et d'estroprogestatifs.