title: Relation between bronchial reactivity to antigen in vivo and serum IgE and IgG2a antibody levels in rats.
abstract: Sprague Dawley rats were immunized with graded doses of ovalbumin (OA) together with alum. The capacity of the animals to produce a bronchial anaphylactic response to intravenous antigen challenge was related to serum OA-IgE and OA-IgG2a antibody levels estimated by radioimmunoassay. A significant correlation between bronchial anaphylactic response capacity and OA-IgE antibody levels was found under a few, but not all, of several carefully chosen experimental conditions. No correlation was demonstrable between the in vivo reactivity of the animals and their serum levels of OA-specific IgG2a antibodies.
mesh_terms: D000707:Anaphylaxis / Q000175:diagnosis / Q000276:immunology*; D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D001986:Bronchial Spasm / Q000175:diagnosis / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D000941:Antigens; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D010047:Ovalbumin