Electronmicroscopy of conjunctival biopsy in mannosidosis.
Electronmicroscopic examination was performed on conjunctival biopsies from two adolescent siblings with mannosidosis. Fibroblasts and endothelial cells contained membrane-bound vacuoles and vesicles that contained homogeneous osmiophilic globules. These vesicles seem to be pathognomonic of mannosidosis. Plasma cells also contained membrane-bound vacuoles, suggesting inhibition of the immunoglobulin production.
D000328:Adult; D001706:Biopsy; D002648:Child; D003228:Conjunctiva / Q000648:ultrastructure*; D005260:Female; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008361:Mannosidases / Q000172:deficiency*; D014617:Vacuoles / Q000648:ultrastructure
D008361:Mannosidases