A simple radioimmunoassay of acebutolol in plasma.
Antisera against acebutolol were produced in rabbits immunized by means of this drug conjugated with bovine serum albumin. These antisera were used to develop a method of radioimmunoassay for acebutolol. The plasma radioimmunoassay, described here, requires no extraction and is very easy to perform besides being quick, specific and sensitive. As little as 2.97 X 10(-9) mol/l of acebutolol can be detected. This radioimmunoassay is suitable for assaying the large number of samples usually measured in pharmacological studies.
D000070:Acebutolol / Q000097:blood*; D000818:Animals; D000918:Antibody Specificity; D003429:Cross Reactions; D006801:Humans; D007106:Immune Sera; D011817:Rabbits / Q000276:immunology; D011863:Radioimmunoassay / Q000379:methods*
D007106:Immune Sera; D000070:Acebutolol