[Studies in animal experiments on determination of blood and organ levels of o-(beta-hydroxyethyl)-rutosides (HR) after i.p. administration (author's transl)].
The concentration of O-(beta-hydroxyethyl)-rutosides (HR, Venoruton) in different organs and serum was investigated after i.p. injections in C3H-mice. There was found a distinct but brief maximum level in serum within 10 to 25 min after i.p. injection. This result explains some of the positive and negative papers about the problem of radiation protection by HR. Therefore it seems important to expand knowledge on time factors and excretion mode of HR in different organs and serum to judge on the radioprotective ability of this substance.
D000818:Animals; D006896:Hydroxyethylrutoside / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D012431:Rutin / Q000031:analogs & derivatives*; D013997:Time Factors; D014018:Tissue Distribution
D006896:Hydroxyethylrutoside; D012431:Rutin
Tierexperimentelle Untersuchungen zur Bestimmung von Wirkstoffkonzentrationen in Blut und Organen nach intraperitonealer Verabreichung von O-(beta-Hydroxyethyl)-rutosiden.