title: Acute retinal necrosis syndrome.
abstract: Six patients with the acute retinal necrosis (ARN) syndrome are described. Ophthalmoscopic examination demonstrated occlusion of peripheral retinal vessels and patchy areas of peripheral retinal whitening spreading rapidly over a period of weeks to markedly decreased vision. In four patients, the disease was bilateral. Histologic examination of vitrectomy specimens from three cases and one enucleated eye revealed chronic granulomatous inflammation. Extensive medical evaluations were noncontributory, with no evidence of compromised immune systems. No patient demonstrated a response to any form of therapy. The etiology is unknown.
mesh_terms: D000208:Acute Disease; D000368:Aged; D002648:Child; D005260:Female; D005451:Fluorescein Angiography; D006099:Granuloma / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D010689:Phlebitis / Q000473:pathology; D012160:Retina / Q000473:pathology; D012163:Retinal Detachment / Q000473:pathology; D012164:Retinal Diseases / Q000473:pathology*; D012166:Retinal Hemorrhage / Q000473:pathology; D012171:Retinal Vessels / Q000473:pathology; D012173:Retinitis / Q000473:pathology; D014792:Visual Acuity; D014822:Vitreous Body / Q000473:pathology