title: Enhancement of Naja naja atra antivenin production in horses.
abstract: As the conventional hyperimmunization schedule in horses introduced by Tanaka could not produce enough neutralizing antibody against Naja naja atra venom, the mixture of Carboxymethyl cellulose (CMC)-Cobra venom incorporated with adjuvant was used for immunization. The neutralizing antibody produced (30 LD50) seemed to be increased but still not to reach the satisfactory level. By using CMC-Cobratoxin adjuvant mixture as an immunizing agent, highly potent antivenin (220 LD50) was obtained.
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000997:Antivenins / Q000276:immunology*; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology; D004546:Elapid Venoms; D006736:Horses / Q000276:immunology*; D007106:Immune Sera / Q000032:analysis
chemical_list: D000276:Adjuvants, Immunologic; D000997:Antivenins; D004546:Elapid Venoms; D007106:Immune Sera; D002266:Carboxymethylcellulose Sodium