Anatomical correlates of morphine-withdrawal syndrome: differential participation of structures located within the limbic system and striatum.
Morphine-withdrawal signs have been induced, in morphine-dependent rats, by microinjection of naloxone in various diencephalic and telencephalic structures. A differential participation of the central amygdala, lateral septum, dorsal hippocampus, medial thalamic nuclei, globus pallidus and caudateputamen has been observed for the following signs: jumping, wet-dog shakes, paw tremor, chewing and diarrhea. Amygdala, medial thalamus and globus pallidus were the most sensitive to local injection of naloxone.
D000818:Animals; D003342:Corpus Striatum / Q000503:physiopathology*; D006801:Humans; D008032:Limbic System / Q000503:physiopathology*; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000209:etiology*
D009270:Naloxone; D009020:Morphine