title: [Effect of the ingestion of soybean fractions, raw or autoclaved, on the rat thyroid].
abstract: Feeding rats for 16 days a water soluble fraction from raw soy flour caused a 40% enlargement of thyroid weight, a similar decrease of 131I uptake and an increase of tri-iodo-thyronine-binding capacity of rat serum. This effect was heat labile. The same fraction autoclaved was able to reduce radioactive iodine uptake and to decrease T3-binding capacity. In longer assays (29 days) this same fraction produced a 30% increase of 131I uptake and altered thyroid hormones increasing T3 and T4 synthesis. An increase of MIT/DIT and a decrease of T3/T4 ratios was also observed by the authors.
mesh_terms: D000818:Animals; D005433:Flour / Q000009:adverse effects; D006358:Hot Temperature; D007457:Iodine Radioisotopes / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013025:Glycine max / Q000009:adverse effects*; D013961:Thyroid Gland / Q000378:metabolism*; D013963:Thyroid Hormones / Q000378:metabolism*; D014284:Triiodothyronine / Q000097:blood
chemical_list: D007457:Iodine Radioisotopes; D013963:Thyroid Hormones; D014284:Triiodothyronine
vernacular_title: Efeito da ingestão de frações de soja crua ou autoclavada sobre a tireóide de ratos.