[Effect of liposomes of different size, composition and charge on the colony-forming ability of cells].
Influence of liposomes on the colony-forming ability of LL cells was studied. Inhibition of cell proliferative activity was revealed as a result of using multilamellar and unilamellar neutral, positively and negatively charged liposomes at similar lipid concentrations (0.2-0.3 mumol/ml). Viability of the cells evaluated from eosine staining was 90-95% immediately after liposomal treatment as was the case at all the cultivation time-points similar to control. Quantitation of the cells during cultivation after liposomal treatment showed that suppression of the proliferation occurs at the first day after the cells-vesicule contact.
D000818:Animals; D002455:Cell Division; D002460:Cell Line; D002470:Cell Survival; D003114:Colony-Forming Units Assay; D007942:Leukemia, Experimental / Q000473:pathology*; D008081:Liposomes / Q000494:pharmacology*; D051379:Mice; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; D013010:Sonication
D008081:Liposomes; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines
Vliianie liposom razlichnoĭ velichiny, sostava i zariada na kolonieobrazuiushchuiu sposobnost' kletok.