[Influence of piridoxilate on the energy metabolism of normothermic ischemic organs in the rat].
In Wistar rats thermocontrolled normothermic ischemia of the whole body was induced 20 min after i.p. injection of 300 mg piridoxilate (Glyco-6) per kg body weight or Ringer's solution in a control group. Piridoxilate pretreatment did not influence the amount of total adenine nucleotide loss in 30 min of normothermic ischemia of forebrain, skeletal muscle, liver or kidney but resulted in a significantly higher loss in myocardium and lung. A positive effect on the conversation of energy rich substances was found only in the skeletal muscle (creatine phosphate content). Significant effects on substrates of glycolysis were found only in myocardium and lung but in the myocardium also a higher accumulation of lactate occurred.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects*; D007511:Ischemia / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011736:Pyridoxine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats
D001786:Blood Glucose; D007773:Lactates; C001310:pyridoxilate; D000255:Adenosine Triphosphate; D011736:Pyridoxine
Der Einfluss von Piridoxilat aud den Energiesstoffwechsel normotherm ischämischer Organe der Ratte.