title: [Penetration and antifungal activity of ciclopiroxolamine in hornified tissue (author's transl)].
abstract: A brief survey is given on microbiological methods commonly used in investigations on the penetration of effective amounts of antimycotics into the epidermis. By means of more recent and widely improved techniques, 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone, 2-aminoethanol salt (ciclopiroxolamine, Batrafen) when applied in a sufficient amount--was shown to penetrate (enter) to an exceptional extent both average and very thick horny layers of skin as well as compact horny material.
mesh_terms: D000042:Absorption; D000818:Animals; D000935:Antifungal Agents / Q000378:metabolism*; D002417:Cattle; D000077768:Ciclopirox; D004305:Dose-Response Relationship, Drug; D006733:Horns / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008825:Miconazole / Q000378:metabolism; D011728:Pyridones / Q000378:metabolism* / Q000494:pharmacology; D012869:Skin Absorption
chemical_list: D000935:Antifungal Agents; D011728:Pyridones; D000077768:Ciclopirox; D008825:Miconazole
vernacular_title: Zur Penetration und antimyzetischen Wirksamkeit von Ciclopiroxolamin in verhorntem Körpergewebe.