Evaluation of the hypolipaemic activity of etofylline clofibrate, a new ester of etofylline and clofibric acid, and comparison with effects of known hypolipaemic agents.
1-(Theophyllin-7-yl)-ethyl-2-[2-(p-chlorophenoxy)-2-methylpropionate] (etofylline clofibrate, ML 1024, Duolip) was compared with several reference compounds for effects on serum cholesterol and triglyceride levels of hypercholesterolaemic rats. ML 1024 appeared to be superior to the reference compounds in reducing cholesterol and triglyceride levels and may have a different mechanism of action to clofibrate.
D000818:Animals; D002784:Cholesterol / Q000097:blood; D002994:Clofibrate / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004032:Diet; D005260:Female; D000960:Hypolipidemic Agents / Q000494:pharmacology; D051381:Rats; D014280:Triglycerides / Q000097:blood
D000960:Hypolipidemic Agents; D014280:Triglycerides; C028764:etofylline clofibrate; D002784:Cholesterol; D002994:Clofibrate