title: [Presynaptic adrenergic mechanisms of action of oxilofrin].
abstract: The presynaptic adrenergic mechanisms of action of 1-(4-hydroxyphenyl)-2-methylamino-propanol-(1) (4-HMP, oxilofrine) were investigated in the rat. The sympathicomimetic agent is stored in the heart by a mechanism with saturation characteristics, resembling noradrenaline in this respect. Inhibitors of the neuronal and extraneural binding of noradrenaline at the same time suppress the tissular uptake of 4-HMP. Investigations in vivo in the tissular distribution and on the subcellular distribution in the iris, vas deferens and spleen confirm the affinity of 4-HMP for the storage vesicles containing noradrenaline. Stimulation of the spinal nerves results in a release of the sympathicomimetic agent. This underlines the significance of the presynaptic mechanisms of action for the pharmacological properties of 4-HMP.
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D004809:Ephedrine / Q000031:analogs & derivatives*; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D011412:Propanolamines / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D013347:Subcellular Fractions / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology; D013566:Sympathomimetics / Q000378:metabolism / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects*; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D006892:Hydroxydopamines; D011412:Propanolamines; D013566:Sympathomimetics; C026055:oxilofrine; D004809:Ephedrine; D009638:Norepinephrine
vernacular_title: Präsynaptische adrenerge Wirkmechanismen von Oxilofrin.