title: The effects of egg yolk diet on serum lipids, aortic atherosclerosis and connective tissue in male miniature pigs.
abstract: The effects of feeding an experimental diet consisting of 16.25% (w/w) dry powdered egg yolk and 30.8% total fat (20% from lard) was compared with an isocaloric amount of control (stock) regimen in male Hormel miniature pigs. The experimental diet was started at 30 weeks of age. The serum lipids (cholesterol and triglycerides) were determined at 5- week intervals until 55 weeks of age. At 55 weeks, the pigs were sacrificed and aortae evaluated for fatty streaks and atherosclerotic lesions. The ingestion of egg yolk diet resulted in hypercholesterolemia as the final serum fold over its initial value. Initial and final serum cholesterol levels of the controls were not statistically different. Triglyceride concentrations were nof influenced by an egg yolk regimen. It was observed that thoracic and abdominal atherogenesis was markedly increased in pigs fed the experimental diet as compared to the controls. No lesions were observed in the coronary arteries. There were no significant changes in the percent of collagen, elastin or C/E ratio in the thoracic and abdominal aortae as well as the coronary arteries. These results indicate that feeding miniature pigs an egg yolk : larg diet produced hypercholesterolemia, increased fatty streaking and atherosclerosis in the aortae.
mesh_terms: D000818:Animals; D001018:Aortic Diseases / Q000209:etiology*; D001161:Arteriosclerosis / Q000209:etiology*; D002784:Cholesterol / Q000097:blood; D003094:Collagen / Q000032:analysis; D004036:Diet, Atherogenic; D004530:Egg Yolk / Q000009:adverse effects*; D004549:Elastin / Q000032:analysis; D005260:Female; D008055:Lipids / Q000097:blood*; D008297:Male; D013552:Swine; D014280:Triglycerides / Q000097:blood
chemical_list: D008055:Lipids; D014280:Triglycerides; D003094:Collagen; D004549:Elastin; D002784:Cholesterol