Intravenous self-administration of nomifensine in rats: implications for abuse potential in humans.
Rats acquired and maintained intravenous self-administration of nomifensine, a new antidepressant compound. Additional experiments implicated dopamine-containing neurons in this behavior. These findings, along with the marked pharmacological similarities between nomifensine and such drugs as cocaine and methylphenidate, indicate a potential for nomifensine abuse by humans.
D000818:Animals; D006801:Humans; D007275:Injections, Intravenous; D007546:Isoquinolines / Q000009:adverse effects*; D008297:Male; D009627:Nomifensine / Q000008:administration & dosage / Q000009:adverse effects*; D010868:Pimozide / Q000494:pharmacology; D051381:Rats; D012054:Reinforcement, Psychology / Q000187:drug effects; D012646:Self Administration; D012653:Self Stimulation / Q000187:drug effects; D019966:Substance-Related Disorders
D007546:Isoquinolines; D010868:Pimozide; D009627:Nomifensine