The effects of dietary fat and lead ingestion on blood lead levels in mice.
To examine the effects of dietary fat on the levels of lead in the blood, 34-40-d-old male mice were fed normal or high-fat diets along with distilled water for an initial 48-h exposure period. Following this session, subjects from each diet condition were administered either 0, 0.075, or 0.5% lead acetate through the drinking water during the next 48 h along with their respective diets. Atomic absorption was used to analyze blood-lead levels. At each concentration of lead, the high-fat diet increased the blood lead content over subjects fed the control diet. The highest blood lead levels were found in the 0.5% lead acetate, high-fat diet condition. The importance of nutritional considerations in understanding lead toxicity is discussed.
D000818:Animals; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D004326:Drinking; D007408:Intestinal Absorption / Q000187:drug effects; D007854:Lead / Q000097:blood / Q000378:metabolism*; D008297:Male; D051379:Mice; D013054:Spectrophotometry, Atomic
D004041:Dietary Fats; D007854:Lead