Comparative coronary vasodilatory effects of nifedipine and niludipine.
Comparative coronary vasodilatory effects of nifedipine and niludipine were studied in normal anesthetized dogs. Nifedipine increased the coronary blood outflow by 142% at 2 min after administration of 10 micrograms/kg and the duration of the effect was over 30 min. On the other hand, niludipine increased the coronary blood outflow by 200% at 2 min after the injection of 25 micrograms/kg and the duration of the effect was over 60 min. Niludipine is a potent calcium antagonistic coronary vasodilator with less cardiodepressant effect than nifedipine. Both drugs are clinically useful as coronary vasodilators and hypotensive agents.
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000187:drug effects; D009543:Nifedipine / Q000031:analogs & derivatives / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects*
D011725:Pyridines; C019497:niludipin; D009543:Nifedipine