title: Effects of variations in time and dose of diazepam injection on delayed hypersensitivity.
abstract: Administration of diazepam was suggested to exert immuno-suppressive properties in mice. In the present study, we explored the time and dose-dependence of diazepam effects on delayed hypersensitivity to sheep erythrocytes in Balb/c mice. DTH response was only depressed when diazepam was injected shortly after immunization and this effect on DTH induction was found with doses of 4 and 8 mg/kg ip while lower doses (0, 5, 1 and 2 mg/kg) remained ineffective.
mesh_terms: D000818:Animals; D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006968:Hypersensitivity, Delayed / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D013997:Time Factors
chemical_list: D003975:Diazepam