title: [Pharmacokinetics of oxametacin in healthy volunteers following multiple administration (author's transl)].
abstract: In a double-blind cross-over study 2 groups of 6 healthy volunteers were dosed with 2 x 75 mg and 3 x 75 mg/d oxametacin (1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolylacethydroxamic acid). Plasma concentrations of oxametacin and indometacin metabolites were compared. 6 volunteers received 2 x 75 mg oxametacin/d for the first 5 d. Thereafter a drug-free period (1 week) followed and finally they received 3 x 75 mg drug/d a further 5 d. The second group of 6 was dosed identically in the reverse order. Plasma concentrations of oxametacin metabolites were significantly higher after the 3 x 75 mg daily dose than after the 2 x 75 mg dose. The steady-state level for both doses was reached by the 3rd d of treatment. The elimination half-life t 1/2 (beta) for the total sum of the oxametacin metabolites was 11.5 (h) and 9.9 (h) after 2 x 75 mg and 3 x 75 mg/d, resp., thus being comparable.
mesh_terms: D000328:Adult; D001711:Biotransformation; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000031:analogs & derivatives* / Q000097:blood; D007700:Kinetics; D008297:Male
chemical_list: C019028:oxamethacin; D007213:Indomethacin
vernacular_title: Pharmakokinetik von Oxametacin nach Mehrfachdosierung bei gesunden Probanden.