Persistence of the expression of beta-tropomyosin in dystrophic avian pectoral muscle.
The isotype pattern of tropomyosin was investigated in normal and dystrophic avian pectoral muscle using two-dimensional gel electrophoresis. Previous reports have shown that adult pectoral muscle of chickens contains only the alpha-subunit of tropomyosin and a breast-type troponin-T (TN-T), whereas pectoral fetal muscle contains both alpha-and beta-tropomyosin and leg-type TN-T. The change from the fetal to the adult forms begins shortly after hatching. It has been previously reported that avian dystrophic pectoral muscle contains both the leg- and breast-type TN-T; we show that in avian dystrophic muscle there is also persistent expression of the beta-subunit of tropomyosin.
D000375:Aging; D000818:Animals; D002642:Chick Embryo; D002645:Chickens / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D009137:Muscular Dystrophy, Animal / Q000378:metabolism*; D010369:Pectoralis Muscles / Q000196:embryology / Q000378:metabolism*; D014335:Tropomyosin / Q000378:metabolism*
D014335:Tropomyosin