Tetrahydro-beta-carbolines: affinities for tryptamine and serotonergic binding sites.
The affinities of four tetrahydro-beta-carbolines at [3H]tryptamine, [3H]5-HT (5-HT1), and [3H]spiperone (5-HT2) binding sites in rat cerebral cortex were investigated. The unsubstituted tetrahydro-beta-carboline was the most potent of the four compounds at all three binding sites, but was 200-400 times more potent at the tryptamine site than at either of the serotonin sites.
D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism; D002243:Carbolines / Q000378:metabolism*; D007211:Indoles / Q000378:metabolism*; D007700:Kinetics; D008238:Lysergic Acid Diethylamide / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism
D002243:Carbolines; D007211:Indoles; D011985:Receptors, Serotonin; D013134:Spiperone; D008238:Lysergic Acid Diethylamide