Mydriatic effectiveness of hydroxyamphetamine.
For routine mydriasis, many clinicians prefer to utilize a combination of adrenergic and anticholinergic agents. Some clinicians, however, omit the adrenergic agent because of a real or perceived fear of inducing adverse systemic side effects. The agent most often implicated in causing side effects is 10% phenylephrine. Although the 2 1/2% concentration rarely results in adverse systemic side effects when applied topically for pupillary dilation, we undertook this study to determine whether another adrenergic agent, 1% hydroxyamphetamine, which lacks the notoriety of phenylephrine, would be equally effective in producing mydriasis.
D000328:Adult; D000662:Amphetamines / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D009184:Mydriatics / Q000494:pharmacology*; D010656:Phenylephrine / Q000494:pharmacology*; D011897:Random Allocation; D012025:Reflex, Pupillary / Q000187:drug effects*; D014331:Tropicamide / Q000494:pharmacology; D010136:p-Hydroxyamphetamine / Q000494:pharmacology*
D000662:Amphetamines; D009184:Mydriatics; D010656:Phenylephrine; D010136:p-Hydroxyamphetamine; D014331:Tropicamide