Renal toxicity studies of protein-bound platinum(cis).
Incubation of dialyzed rat serum with cisplatin at a concentration of 908 ppm results in binding of platinum to the proteins and electrophoretic evidence of protein alterations. Intravenous administration of protein-bound platinum(cis), containing the same platinum content as an 8.5-mg/kg dose of cisplatin, fails to produce elevated serum BUN and creatinine levels as do equivalent doses of 'free' cisplatin in 0.9% saline. Light microscopy of the right side kidneys of rats receiving protein-bound platinum(cis) revealed no obvious pathology while the kidneys of rats receiving 'free' cisplatin showed consistent pathological alterations including hydropic degeneration and pyknotic nuclei. These observations suggest that a protein-bound form of platinum will be unlikely to contribute to the renal toxicity observed during cisplatin chemotherapy.
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001806:Blood Urea Nitrogen; D002945:Cisplatin / Q000097:blood / Q000633:toxicity*; D003404:Creatinine / Q000097:blood; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D011485:Protein Binding; D051381:Rats
D001798:Blood Proteins; D003404:Creatinine; D002945:Cisplatin