The use of automated headspace gas chromatography for determination of 1,1,1-trichloroethane in rat blood and brain tissue.
1,1,1-trichloroethane in blood and brain tissue from rats which had been artificially ventilated with solvent (8000 ppm) was analysed by automated headspace gas chromatography using a fused silica capillary column. A given concentration of 1,1,1-trichloroethane in the brain could be correlated with a corresponding concentration in the blood; both the uptake and release of the solvent were quicker in blood than in brain. No volatile metabolites of the solvent were found. Automated headspace gas chromatographic analysis is a rapid and sensitive technique for the quantitative registration of volatile organic solvents, e.g. of industrial importance, in body fluids and tissues.
D000818:Animals; D001322:Autoanalysis; D001923:Brain Chemistry; D002849:Chromatography, Gas / Q000379:methods; D006843:Hydrocarbons, Chlorinated / Q000032:analysis*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014240:Trichloroethanes / Q000032:analysis* / Q000097:blood
D006843:Hydrocarbons, Chlorinated; D014240:Trichloroethanes; C024566:1,1,1-trichloroethane