Inhibition of 1-methyl-1-nitrosourea-induced mammary carcinogenesis in the rat by the retinoid axerophthene.
The hydrocarbon retinoid, axerophthene, and retinyl acetate were compared for their ability to prevent mammary cancer induced in rats by 1-methyl-1-nitrosourea. Chronic feeding of both retinoids delayed the appearance and lessened the incidence of cancers; retinyl acetate was definitely more active. However, axerophthene was significantly better tolerated by the rats and allowed normal weight gain when fed in high doses, in contrast to retinyl acetate.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004224:Diterpenes; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D008770:Methylnitrosourea / Q000037:antagonists & inhibitors*; D009607:Nitrosourea Compounds / Q000037:antagonists & inhibitors*; D051381:Rats; D013997:Time Factors; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology
D004224:Diterpenes; D009607:Nitrosourea Compounds; D014801:Vitamin A; D008770:Methylnitrosourea; C016250:axerophthene