Influence of bromfenvinfos alone and in mixture with methoxychlor on the blood indices of laboratory mice.
Bromfenvinfos (O,O-diethyl-O-1-(2,4-dichlorphenyl)-2-bromvinyl phosphate, BrV, 12.23 mg/kg/day) alone and in combination with methoxychlor (1,1,1-trichlor-2,2-(4-methoxyphenyl) ethane, MeOCl, 24.66 mg/kg/day) were administered per os daily for 6 weeks to male and female laboratory mice in the olive-oil suspension. Total leukocyte and erythrocyte count, hemoglobin level, the percentage of leukocytes and the plasma proteins were determined. BrV and BrV + MeOCl depressed the blood hemoglobin level; BrV and BrV + MeOCl treatment reduced also the erythrocyte diameter.
D000818:Animals; D001769:Blood / Q000187:drug effects*; D001772:Blood Cell Count; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002709:Chlorfenvinphos / Q000031:analogs & derivatives / Q000633:toxicity*; D004912:Erythrocytes / Q000648:ultrastructure; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D008731:Methoxychlor / Q000633:toxicity*; D051379:Mice
D001798:Blood Proteins; D007306:Insecticides; C014369:bromfenvinphos; D002709:Chlorfenvinphos; D008731:Methoxychlor