Hydrophobicity and antifilarial activities of 4-aminoquinolines.
The apparent partition coefficients (Papp.) of eight 4-aminoquinolines in 1-octanol/pH 7.4 buffered solutions have been determined and correlated with their reported antifilarial activities. Antifilarial activity appears to be present only in those 4-aminoquinolines which have log Papp. values falling within a narrow range of 2.8 to 3.2.
D000634:Aminoquinolines / Q000494:pharmacology*; D000871:Anthelmintics / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D005369:Filaricides / Q000494:pharmacology*; D012995:Solubility
D000634:Aminoquinolines; D000871:Anthelmintics; D005369:Filaricides