[Dynamics and physiological significance of GABA-system activation in brain and cardiac muscle during emotional-pain stress].
Effect of emotional-painful stress (EPS) on activity of the gamma-aminobutyric acid (GABA) system was studied in animal brain hemispheres and heart muscle. Activation of the GABA-system, developed in brain and heart tissues after EPS, exhibited various physiological importance in the tissues. In brain tissue activation of the GABA-system occurred together with inhibition of FAD-dependent oxidation of succinate in tricarboxylic acid cycle and therefore it might lead to an increased accumulation of the inhibitory metabolite gamma-hydroxybutyric acid, which is important in limitation of the stress stimulation. In heart muscle activation of the GABA-system was realized simultaneously with an increase in FAD-dependent oxidation of succinate and could represent the shunt, which enables to produce the additional amount of succinate, in spite of inhibition of NAD-dependent oxidation of alpha ketoglutarate in tricarboxylic acid cycle. The functioning of the GABA-system as the shunt, responsible for high intensity of FAD-dependent oxidation, might be important both in sufficient resynthesis of ATP in heart muscle and in formation of additional amount of NADPH, essential for biosynthesis.
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005968:Glutamate Decarboxylase / Q000378:metabolism; D006801:Humans; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D010146:Pain / Q000378:metabolism*; D051381:Rats; D013312:Stress, Physiological / Q000201:enzymology / Q000378:metabolism*; D013315:Stress, Psychological / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D000612:4-Aminobutyrate Transaminase; D005968:Glutamate Decarboxylase
Dinamika i fiziologicheskoe znachenie aktivatsii GAMK-sistemy v golovnom mozge i serdechnoĭ myshtse pri émotsional'no-bolevom stresse.