Contrast media induced serotonin release in human blood.
Several contrast media were tested for their ability to release serotonin from whole blood. Renografin-60, Hypaque M-75, Vascoray and Conray were incubated with human blood at 37 degrees C for 60 min. Platelet-poor plasma was analysed for serotonin using a high performance liquid chromatographic technique. Seven non-ionic contrast media were similarly incubated and serotonin levels determined. Ionic contrast media induced a greater release of serotonin compared with non-ionic ones. The amount of serotonin was not proportional to iodine concentration in blood. These results suggest that hypertonic solutions of contrast media produce a physical injury to platelets causing them to release their granular contents.
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003287:Contrast Media / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007455:Iodine / Q000097:blood; D008297:Male; D012701:Serotonin / Q000097:blood*
D003287:Contrast Media; D012701:Serotonin; D007455:Iodine