Influence of sympathetic tonus and plasma noradrenaline on urethral pressure.
The relative influence of circulating noradrenalin and sympathetic tonus on urethral pressure was investigated by intravenous administration of noradrenalin and clonidine. Raising circulating noradrenalin concentrations by noradrenalin infusion had only a relatively minor effect on urethral pressure, indicating that urethral pressure is not controlled by circulating noradrenalin. Besides depression of sympathetic tonus and urethral pressure, clonidine reduced striated anal sphincter activity.
D000328:Adult; D001003:Anal Canal / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000097:blood* / Q000494:pharmacology; D011312:Pressure; D013564:Sympathetic Nervous System / Q000502:physiology*; D014521:Urethra / Q000502:physiology*
D003000:Clonidine; D009638:Norepinephrine