Influence of carbocromen on some metabolic parameters of isolated working guinea pig hearts.
The influence of carbocromen (chromonar) on both functional and some metabolic parameters of isolated guinea pig hearts was tested over a broad concentration range and with different exogenous substrates. As revealed from a shift of the myocardial respiratory quotient, carbocromen (in the upper coronary active concentration range) induced an increased glucose utilization at the expense of FFA oxidation. Theoretically, this may indicate a relative reduction of myocardial oxygen demand, but the therapeutic relevance of this observation still remains obscure, as an additional exogenous FFA supply may override this biochemical carbocromen effect.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002866:Chromonar / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects; D003374:Coumarins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism / Q000187:drug effects*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006168:Guinea Pigs; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects
D001786:Blood Glucose; D003374:Coumarins; D005230:Fatty Acids, Nonesterified; D002866:Chromonar