Pallidonigral pigmentation and spheroid formation with multiple striatal lacunar infarcts.
A 72-year-old hypertensive man had focal seizures and mild memory loss. At autopsy, there were many lacunar infarcts, particularly in the neostriatum. Rust-brown discoloration and spheroid formation within the globus pallidus and pars reticulata of the substantia nigra resembled Hallervorden-Spatz disease, in which more detailed analysis of the striatum may be worthwhile.
D000368:Aged; D001284:Atrophy; D001369:Axons / Q000473:pathology*; D001927:Brain Diseases / Q000473:pathology*; D002544:Cerebral Infarction / Q000473:pathology*; D003342:Corpus Striatum / Q000648:ultrastructure; D005917:Globus Pallidus / Q000648:ultrastructure*; D006801:Humans; D008297:Male; D013378:Substantia Nigra / Q000648:ultrastructure*