Effects of experimental atherosclerosis on cerebral blood flow in rabbits. Reversal by sorbinicate.
The present investigations were performed in conscious rabbits with the aim of determining the effects of an atherogenic diet (AD) on the cerebral blood flow (CBF) and of a nicotinic acid derivative (SN) on the CBF alterations induced by the diet. Experimental atherosclerosis reduces the blood flow in the rapidly exchanging cerebrovascular compartment; SN largely counteracts this effect. The experimental data suggest that the effect of this antiatherogenic drug is not due to vasoactive properties.
D000818:Animals; D001158:Arteries / Q000378:metabolism; D001161:Arteriosclerosis / Q000378:metabolism / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008297:Male; D009539:Nicotinic Acids / Q000494:pharmacology*; D011817:Rabbits; D013012:Sorbitol / Q000031:analogs & derivatives* / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
D000960:Hypolipidemic Agents; D009539:Nicotinic Acids; D014280:Triglycerides; C015238:glucitol hexanicotinate; D013012:Sorbitol; D002784:Cholesterol