The action of transition metals on the genotoxicity of simple phenols, phenolic acids and cinnamic acids.
Simple phenols (catechol, 4-methyl catechol, resorcinol, phloroglucinol and pyrogallol), phenolic acids (p-hydroxybenzoic acid, protocatechuic acid, vanillic acid, gallic acid, syringic acid and salicylic acid), a phenylacetic acid (3,4-dihydroxyphenylacetic acid) and eugenol were assayed for clastogenic activity in Chinese hamster ovary (CHO) cells with and without the addition of a n S9 mixture, Cu2+ (10-4M) and Mn2+ (10-4M). All dihydroxylated and trihydroxylated phenolics induced chromatid breaks and exchanges. The introduction of a methyl group seems to reduce the clastogenic capacity. The addition of an S9 mixture or the transition metals Cu2+ and Mn2+ enhanced the chromosome-damaging activity in some phenolics and suppressed it in others.
D000818:Animals; D002460:Cell Line; D002842:Chromatids / Q000187:drug effects*; D002869:Chromosome Aberrations; D002934:Cinnamates / Q000633:toxicity*; D003300:Copper / Q000494:pharmacology*; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D008345:Manganese / Q000494:pharmacology*; D008677:Metaphase; D009153:Mutagens; D010053:Ovary; D010636:Phenols / Q000633:toxicity*
D002934:Cinnamates; D009153:Mutagens; D010636:Phenols; D008345:Manganese; D003300:Copper