Osteoclasts with ruffled borders from above the tip of the erupting incisors of osteopetrotic mice and rats.
Electron microscopy of the bone above the incisor of 10-day-old microphthalmic mice (mi) and incisors absent rats (ia) demonstrated that in both osteopetrotic mutants, osteoclasts indistinguishable from normal and with well-developed ruffled borders were present. Study of the same region in younger and older animals showed the type of abnormal osteoclast typical of the respective mutant strain.
D000818:Animals; D007180:Incisor / Q000473:pathology*; D051379:Mice; D008817:Mice, Mutant Strains; D008854:Microscopy, Electron; D010010:Osteoclasts / Q000473:pathology*; D010022:Osteopetrosis / Q000473:pathology*; D051381:Rats; D011922:Rats, Mutant Strains