Inhibition by clonidine of morphine-induced running fit but not analgesia in C57BL/6 mice.
Clonidine, 0.25 and 0.5 mg/kg, depressed significantly the running fit induced by 10 or 20 mg/kg of morphine in C57BL/6 mice, but did not affect morphine analgesia measured by the "hot plate" test. The results confirm the hypothesis that different mechanisms are involved in the two types of response to morphine, and the running fit response is mediated via a noradrenergic mechanism of action.
D000698:Analgesia; D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009020:Morphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009021:Morphine Dependence / Q000188:drug therapy; D009043:Motor Activity / Q000187:drug effects*; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology
D009020:Morphine; D003000:Clonidine