[In vivo drug release from microencapsulated acetylsalicylic acid with simultaneous alcohol uptake].
Simultaneous uptake of different amounts of ethanol with microencapsulated acetylsalicyclic acid (Colfarit tablets) did not influence the urinary excretion of total salicylates in 7 volunteers. There was no relation to in vitro drug release.
D000328:Adult; D000434:Alcoholic Beverages; D001241:Aspirin / Q000008:administration & dosage / Q000378:metabolism*; D002214:Capsules; D003692:Delayed-Action Preparations; D004347:Drug Interactions; D000431:Ethanol / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D012459:Salicylates / Q000652:urine; D013997:Time Factors; D014920:Wine
D002214:Capsules; D003692:Delayed-Action Preparations; D012459:Salicylates; D000431:Ethanol; D001241:Aspirin
Wirkstoff-Freisetzung aus mikroverkapselter Acetylsalicylsäure unter Alkoholbelastung.