title: Frequency dependence of water proton longitudinal nuclear magnetic relaxation times in mouse tissues at 20 degrees C.
abstract: We have measured the proton longitudinal relaxation times of tissue water of healthy and tumor-bearing mice as a function of the Larmor frequency in the range 6.7 to 90 MHz. These data can be rationalized according to T1-1 = A v -1/2 +B, where A and B are constants specific to the tissue species. We present an interpretation of this frequency dependence within the Fast Exchange Two States model. It is shown that involving a distribution of correlation times for water proton-proton interaction does not yield consistent results, whereas a physically meaningful translational diffusion model pertinent to the dipolar interaction between water protons and macromolecules protons leads to the required frequency dependence. Essentially tissues would differ by the 'bound' versus 'free' proportion, or by structural properties of cells, rather than by the time-scales governing water motion.
mesh_terms: D000818:Animals; D001834:Body Water / Q000032:analysis*; D005260:Female; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008433:Mathematics; D051379:Mice; D008809:Mice, Inbred C3H; D009132:Muscles / Q000032:analysis; D009374:Neoplasms, Experimental / Q000032:analysis; D012208:Rhabdomyosarcoma / Q000032:analysis; D013154:Spleen / Q000032:analysis