title: Reduction of enflurane-induced spike activity by scopolamine.
abstract: The possibility of enflurane-induced spike activity being related to a cholinergic mechanism was investigated. Thirty mongrel dogs were anesthetized with an inspired enflurane concentration of 3.5 +/- 0.09% (mean +/- SD) to obtain a sustained EEG spike activity. Scopolamine, in 0.04 mg/kg to 0.4 mg/kg IV doses, significantly decreased the spike activity (p less than 0.05). We speculate that a central cholinergic muscarinic mechanism is at least partly responsible for the EEG spike activity produced by enflurane.
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D004285:Dogs; D004569:Electroencephalography; D004737:Enflurane; D012601:Scopolamine / Q000494:pharmacology*
chemical_list: D004737:Enflurane; D012601:Scopolamine