title: [Population genetics approach to the problem of nonspecific biological resistance of the human body. II. Clinical characteristics, congenital anomalies and genetic structure of sick children with attention to birth weight and length].
abstract: Clinical analysis of several groups of newborns and infants arranged by 2 metrical characters has shown that morphologically average individuals ("adaptive norm") are most resistant to the wide range of diseases including congenital malformations. The frequency of grave diseases and congenital malformations is much higher in newborns and infants with extreme (especially low) values of characters, each group of extreme variants being characterized by a specific set of diseases. Statistically significant differences in genetic structure of these groups are detected: departures from Hardy-Weinberg equilibrium and lower level of heterozygosity for ABO and Ww loci are observed in a group of children with low weight and body length values. These features are most pronounced in the group comprising dead newborns and infants.
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics; D001724:Birth Weight; D001835:Body Weight; D002571:Cerumen; D000013:Congenital Abnormalities / Q000235:genetics*; D004198:Disease Susceptibility; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D007231:Infant, Newborn; D009017:Morbidity; D010641:Phenotype
chemical_list: D000017:ABO Blood-Group System
vernacular_title: Populiatsionno-geneticheskiĭ podkhod k probleme nespetsificheskoĭ biologicheskoĭ ustoĭchivosti chelovecheskogo organizma. Soobshchenie II. Klinicheskaia kharakteristika, vrozhdennye anomalii i geneticheskaia struktura bol'nykh deteĭ s uchetom ikh vesa i dliny tela pri rozhdenii.