A two-compartment model for digoxin disposition in dogs.
The disappearance of digoxin from heart and skeletal muscle was studied in dogs using a sequential biopsy technique. The animals were injected with digoxin for five days and subsequently with 3H-digoxin for an additional three days. 12, 24, and 48 h after discontinuation of digoxin, tissue samples of left ventricle, left atrial appendage, and skeletal muscle were taken. In addition, digoxin serum levels were measured. With the help of a computer program, a mathematical model was developed for the description of the disposition and elimination of digoxin from tissue. Disappearance from plasma and tissue was consistent with a two-compartment open model.
D000818:Animals; D004077:Digoxin / Q000097:blood / Q000378:metabolism*; D004285:Dogs; D005260:Female; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism; D014018:Tissue Distribution
D004077:Digoxin