title: The migration of macrophages after phagocytosis in chick bone marrow.
abstract: The migration of macrophages in chick bone marrow was studied by histoplanimetry after an intravenous injection of colloidal carbon or iron-dextran. In the initial stages after the injection, carbon-laden macrophages were found only in the sinus, where erythrocytopoiesis took place. The carbon-laden macrophages then passed through the sinus wall and gradually migrated from the sinus to the extravascular area (i.e., the granulocytopoietic region) peaking at 1 to 3 days after injection. After 7 days, almost all the carbon-laden macrophages accumulated to form "macrophage islets" mainly around the lymphatic nodules in the extravascular area. In the cases injected with iron-dextran, the movement of iron-laden macrophages was similar to that of the carbon-laden ones. The similarity suggests that the direction and time of migration of macrophages are independent of ingested materials.
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D002244:Carbon / Q000378:metabolism; D002465:Cell Movement; D002645:Chickens; D007501:Iron / Q000378:metabolism; D008264:Macrophages / Q000166:cytology*; D010587:Phagocytosis
chemical_list: D002244:Carbon; D007501:Iron