Evidence for binding of certain acidic drugs to alpha 1-acid glycoprotein.
The binding of some acidic drugs to alpha 1-AGP was studied by equilibrium dialysis at 37 degrees, pH 7.4. Certain acidic drugs bound to alpha 1-AGP at one binding site with a high affinity. Though the alpha 1-AGP plasma concentration is far lower than the HSA concentration, the association constants of some acidic drugs with alpha 1-AGP are high enough to suggest that binding to alpha 1-AGP will contribute significantly to the total plasma binding of these drugs.
D006801:Humans; D009961:Orosomucoid / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000097:blood*; D011433:Propranolol / Q000097:blood; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism; D014859:Warfarin / Q000097:blood
D009961:Orosomucoid; D004364:Pharmaceutical Preparations; D012709:Serum Albumin; D014859:Warfarin; D011433:Propranolol