A naturally occurring pyrimidodiazepine in Drosophila: chemical and spectral properties and relationship to drosopterin.
The structure of an intermediate, in drosopterin biosynthesis, as 6-acetylpyrimidodiazepine has been confirmed by high-resolution mass spectra, 13C NMR, chemical ionization mass spectra, and chemical properties. A trivial name of 6-acetylhomopterin is suggested and should replace the term "quench spot" used heretofore. The structure of drosopterin includes, in part, a pyrimidodiazepine, a compound that consists of a fused six- and seven-membered heterocyclic ring system. Earlier studies demonstrated that 6-acetylhomopterin strongly stimulated the enzymatic synthesis of drosopterin and related eye pigments by preparations from Drosophila. The occurrence in nature is quite limited for diazepines; drosopterin and homopterin are the first examples in eukaryotes.
D000818:Animals; D001381:Azepines / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D004330:Drosophila / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008961:Models, Structural; D011621:Pteridines / Q000032:analysis*; D011622:Pterins
D001381:Azepines; D011621:Pteridines; D011622:Pterins; C020306:drosopterin; C032200:2-amino-4-oxo-6-acetyl-7,8-dihydro-3H,9H-pyrimidodiazepine