[Effect of castration and mouse strain on 1, 2-dimethylhydrazine induction of pararenal angiosarcomas and kidney adenomas].
Castration preceding the administration of 1, 2-dimethylhydrazine (DMH) to CBA male mice inhibits the induction of pararenal angiosarcomas (from 76% to naught) and renal adenomas (from 89 to 57%). Male mice of different strains treated with DMH developed the following incidences of pararenal angiosarcomas and renal adenomas: C3H - 35.5 and 13%, respectively, CBA - 97 and 78.8%,m (CBA X C57B1) F1-36.1 and 30%. C57B1-4.2 and 23.4%, BALB/c-13 and 43.4%, C3HA -7.1 and 14.3%. Pararenal angiosarcoma develops most likely from vascular bed of renal capsula. The mechanisms of androgen stimulation of renal adenoma and pararenal angiosarcoma induction are discussed.
D019813:1,2-Dimethylhydrazine; D000236:Adenoma / Q000139:chemically induced*; D000818:Animals; D002369:Castration; D004127:Dimethylhydrazines / Q000494:pharmacology*; D006394:Hemangiosarcoma / Q000139:chemically induced*; D007680:Kidney Neoplasms / Q000139:chemically induced*; D008297:Male; D008763:Methylhydrazines / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains / Q000502:physiology*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced; D013997:Time Factors
D004127:Dimethylhydrazines; D008763:Methylhydrazines; D019813:1,2-Dimethylhydrazine
Vliiania kastratsii i linii mysheĭ na induktsiiu pararenal'nykh angiosarkom i adenom pochek 1, 2-dimetilgidrazinom.