Endogenous hyperprolactinaemia enhances amphetamine- and apomorphine-induced stereotypy.
Rats with endogenous hyperprolactinaemia induced by pituitary homografts under the kidney capsule were more sensitive to amphetamine and apomorphine with respect to drug-induced stereotypy, while a normal response was noted in drug-induced changes of locomotor activity, rearing and grooming. It is suggested that postsynaptic dopaminergic receptors, probably in the nigro-striatal system, may become selectively supersensitive in the endogenous hyperprolactinaemic animals.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D004357:Drug Synergism; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D011388:Prolactin / Q000097:blood*; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects* / Q000502:physiology
D011388:Prolactin; D000661:Amphetamine; D001058:Apomorphine