Evaluation of activated charcoal-sorbitol suspension as an antidote.
Studies in rats were performed to evaluate the effect of sorbitol on the antidotal efficacy of activated charcoal against four test drugs and to investigate the influence of storage upon the antidotal effect of activated charcoal-sorbitol suspension. The antidotal potency of activated charcoal was not diminished by sorbitol solution 70% w/v. In fact, it was enhanced by the sorbitol solution, as indicated by greater decrease in peak tissue drug concentration, compared to the effect produced by activated charcoal in aqueous suspension. Furthermore, storage of activated charcoal in sorbitol for as long as 1 year did not reduce the antidotal-efficiency of the absorbent.
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001241:Aspirin / Q000032:analysis / Q000097:blood; D002606:Charcoal / Q000627:therapeutic use*; D002738:Chloroquine / Q000032:analysis / Q000097:blood; D002744:Chlorpheniramine / Q000032:analysis* / Q000097:blood; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D008099:Liver / Q000032:analysis; D008297:Male; D010424:Pentobarbital / Q000032:analysis / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013012:Sorbitol / Q000627:therapeutic use*
D000931:Antidotes; D004338:Drug Combinations; D002606:Charcoal; D002744:Chlorpheniramine; D013012:Sorbitol; D002738:Chloroquine; D010424:Pentobarbital; D001241:Aspirin