Stereocontrolled synthesis of 7-oxabicyclo (2.2.1) heptane prostaglandin analogs as thromboxane A2 antagonists.
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology; D001792:Blood Platelets / Q000201:enzymology; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis*; D006168:Guinea Pigs; D006801:Humans; D008168:Lung / Q000187:drug effects; D008722:Methods; D010974:Platelet Aggregation / Q000187:drug effects; D011465:Prostaglandins, Synthetic / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013928:Thromboxane A2 / Q000494:pharmacology*; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors; D013931:Thromboxanes / Q000494:pharmacology*
D001095:Arachidonic Acids; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D011465:Prostaglandins, Synthetic; D013931:Thromboxanes; D013928:Thromboxane A2; D013930:Thromboxane-A Synthase