Absence of carcinogenic response to cyclamate and saccharin in Sprague-Dawley rats after transplacental application.
Female Sprague-Dawley rats were treated by gavage either with cyclamate or saccharin at doses of 5, 1 and 0.2 g/kg body weight on days 14, 17 and 20 of pregnancy. The offspring were observed throughout their lives. No carcinogenic activity of the exposure in utero to the test compounds was observed. The results of this study support the conclusion that application of the tested artificial sweeteners during pregnancy is not an important risk factor for any type of cancer in Sprague-Dawley rats.
D000818:Animals; D002273:Carcinogens; D003494:Cyclamates / Q000633:toxicity*; D005260:Female; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D012439:Saccharin / Q000633:toxicity*
D002273:Carcinogens; D003494:Cyclamates; D012439:Saccharin