title: Preliminary report on the stimulation of immunity to the larval stage of Taenia multiceps.
abstract: The efficacy of Oncosphere Secretory Antigen (OSA) in protecting sheep against the larval stage of Taenia multiceps was assessed in 47 sheep in 2 trials. In the pilot trial no cerebral coenuri were found in 3 sheep which were treated with OSA 28 and 14 days before challenge with 6 000 eggs of T. multiceps. Cerebral coenuri were present in 3 untreated controls. In the second experiment 30 sheep were similarly treated with OSA and challenged with 5 000 eggs of T. multiceps, while 11 sheep served as untreated controls. At necropsy either developing coenuri or degenerate lesions were present in the brain of 5 (16,6%) of the 30 vaccinated animals while 8 out of 11 (72,7%) of the untreated animals had cerebral coenuri or degenerate lesions in the brain. It is concluded that OSA may be used to protect animals against cerebral coenuriosis.
mesh_terms: D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology*; D013622:Taeniasis / Q000276:immunology / Q000662:veterinary*; D014612:Vaccines / Q000276:immunology
chemical_list: D000941:Antigens; D014612:Vaccines