Influence of ambroxol on the bronchopulmonary level of antibiotics.
Antibiotic levels in bronchopulmonary tissue following oral administration of ampicillin, erythromycin and amoxycillin dosed 50 mg/dg were compared with those obtained by the same treatments n0 mg/dg p.o of trans-4-[(2-amino-3,5-dibromo-benzyl)amino]cyclohexanol (ambroxol, Mucosolvan) in several groups of rats. The addition of ambroxol was correlated with an increase of 234% in the pulmonary average concentration of ampicillin, 27% in that of erythromycin 27% in that of amoxycillin; the statistical evaluation of these differences resulted in less than 0.05 in each case. It may be concluded that ambroxol, through a mechanism still unclear, can increase the antibiotic levels in the lungs of the rat.
D000551:Ambroxol / Q000494:pharmacology*; D000658:Amoxicillin / Q000378:metabolism; D000667:Ampicillin / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001964:Bromhexine / Q000031:analogs & derivatives*; D004347:Drug Interactions; D004917:Erythromycin / Q000378:metabolism; D005260:Female; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats
D000900:Anti-Bacterial Agents; D000551:Ambroxol; D004917:Erythromycin; D000667:Ampicillin; D000658:Amoxicillin; D001964:Bromhexine