[Investigations in animal experiments into the influence of the beta-1-selective blocking agent metoprolol on the cardiovascular and metabolic side effects of the tocolytic fenoterol].
The influence of the highly selective beta-1-adrenergic blocker Metoprolol on cardiovascular and metabolic side effects of the beta-mimetic Fenoterol, used for labour inhibition, was investigated in anesthetized mongrel dogs. In a dosage of 1.5 microgram/kg BW/min Metoprolol antagonized the positive inotropic and chronotropic cardiac effects of Fenoterol (0.06 microgram/kg BW/min) thus compensating the impaired energetic balance of the myocardium. As expected, there was no influence on the beta-mimetic mediated metabolic alterations. Taking into account its pharmacologic actions, the additional application of Metoprolol in labour inhibition with beta-mimetics seems to be advantageous. On account of the proven results a reduction of the more or less considerable missensations and a cardioprotective effect may be expected.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004347:Drug Interactions; D004983:Ethanolamines / Q000009:adverse effects*; D005260:Female; D005280:Fenoterol / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D008790:Metoprolol / Q000494:pharmacology*; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D010100:Oxygen; D010313:Partial Pressure; D011247:Pregnancy; D011412:Propanolamines / Q000494:pharmacology*
D004983:Ethanolamines; D011412:Propanolamines; D005280:Fenoterol; D008790:Metoprolol; D010100:Oxygen
Der Einfluss des Beta-1-selektiven Blockers Metoprolol auf die kardiovaskulären und die metabolischen Nebenwirkungen des Tokolytikums Fenoterol im Tierexperiment.