A double blind crossover tolerance study of AR-L 115 BS in health volunteers.
In a double blind crossover study in 20 healthy volunteers, aged between 19 and 32 years, 2-[(2-methoxy-4-methyl-sulfinyl)phenyl]-1H-imidazo[4,5-b]pyridine (AR-L 115 BS) 100 mg q.i.d. for 1 week was compared with placebo. No drug effect was found on blood pressure (lying and standing, systolic and diastolic), heart rate, full blood count, blood chemistry (including liver functions), urinalysis; no side-effects were reported.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002316:Cardiotonic Agents / Q000009:adverse effects*; D004311:Double-Blind Method; D004341:Drug Evaluation; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D008297:Male
D002316:Cardiotonic Agents; D007093:Imidazoles; C029758:sulmazole