Studies on osteoporosis. IX. Effect of fluoride on steroid induced osteoporosis.
Neutron activation analysis was employed to determine total body calcium in 5-8 month and 15-18 month old C3H/St(Ha) and C57/BL6 (JACOBS) female mice. Ninety-nine percent of calcium is in bone and loss of calcium was used as an index of osteoporosis. Prednisolone (50 mg/kg q.d.) treatment for three months resulted in significant osteoporosis in the C3H/St(Ha) mice of both age groups but did not cause significant bone loss in the C57/BL6 (JACOBS) mice of either age group. Fluoride (75 PPM) failed to prevent osteoporosis in both strains and both age groups.
D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D005260:Female; D005459:Fluorides / Q000494:pharmacology*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D010024:Osteoporosis / Q000139:chemically induced* / Q000517:prevention & control; D011239:Prednisolone / Q000009:adverse effects
D000305:Adrenal Cortex Hormones; D011239:Prednisolone; D005459:Fluorides; D002118:Calcium