[Emotionally positive reactions in the process of development of diazepam dependence].
Rats with lateral hypothalamic electrodes were treated with diazepam in doses of 10--20 mg/kd during 10 days. Part of the animals showed tolerance to the inhibitory effect of the drug. Within the drug administration period depression of the self-stimulation response was observed under 24-hour abstinence. After diazepam withdrawal two forms of abstinent changes were noted--inhibition and facilitation. The effects of diazepam were modulated by opiate receptors' blockade with naloxon.
D000818:Animals; D003975:Diazepam / Q000009:adverse effects / Q000037:antagonists & inhibitors; D004195:Disease Models, Animal; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D012653:Self Stimulation / Q000187:drug effects*; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis; D019966:Substance-Related Disorders
D009270:Naloxone; D003975:Diazepam
Emotsional'no-pozitivnye reaktsii v protsesse formirovaniia zavisimosti ot diazepama.