Transformation of rifamycin S into rifamycins B and L. A revision of the current biosynthetic hypothesis.
The transformation of rifamycin S into rifamycins B and L was reinvestigated in order to establish more detailed pathways. Our results exclude rifamycin O as a common progenitor in the biosyntheses of rifamycins B and L. Rifamycins B and L are formed from rifamycin S (SV) by different pathways using different C3-precursors for the biosynthesis of their glycolic acid moieties. A thiamine-dependent enzyme (decarboxylase) seems to be involved in the transformation reaction.
D000164:Acremonium / Q000378:metabolism; D000963:Antimetabolites / Q000494:pharmacology; D001711:Biotransformation; D006016:Glycolates / Q000378:metabolism; D008954:Models, Biological; D009615:Nocardia / Q000378:metabolism; D012294:Rifamycins / Q000096:biosynthesis* / Q000378:metabolism*
D000963:Antimetabolites; D006016:Glycolates; D012294:Rifamycins; C033975:rifamycin L; C033974:rifamycin B; C023808:rifamycin SV; C032779:rifamycin S