title: [New cerebrally active basic dithienyl compounds (author's tranls)].
abstract: A review on new cerebrally active basic dithienyl compounds related to (+)-(R)-alpha-((S)-1-[(3,3-di-3-thienylallyl)amino]-ethyl)-benzylalcohol (tinofedrine) is presented. Tinofedrine was selected out of a large number of related compounds on account of its high increase of cerebral blood flow, its improvement of heart performance, of the metabolism of the brain, and because it is well toleraded. Different routes of synthesis are discussed.
mesh_terms: D000818:Animals; D001592:Benzyl Alcohols / Q000138:chemical synthesis / Q000494:pharmacology*; D001593:Benzyl Compounds / Q000494:pharmacology*; D001809:Blood Viscosity / Q000187:drug effects; D001923:Brain Chemistry; D002302:Cardiac Output / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
chemical_list: D001592:Benzyl Alcohols; D001593:Benzyl Compounds; D013876:Thiophenes; D014280:Triglycerides; C018159:tinofedrine
vernacular_title: Neue zerebral wirksame basische Dithienyl-Verbindungen.