Embryotoxic effects of magnesium deficiency and stress on rats and mice.
Pregnant rats an mice received a magnesium (Mg)-deficient diet with different Mg contents from 40 t 360 ppm. The control received 2,000 ppm. At the end of gestation, the Mg concentration in the maternal serum was found to have decreased by up to 0.3 mmole/liter, depending on the Mg content of the food. Mg-dose-dependent embryotoxic effects (resorptions, retardation, disturbed bone development, and skeletal malformations) were observed only below a threshold value of 0.7 mmole/liter of the maternal serum Mg concentration. Noise stress in rats, in addition to a mild Mg deficiency (360 ppm Mg), which by itself had no effects, increased the rate of resorptions only.
D000818:Animals; D001848:Bone Diseases, Developmental / Q000196:embryology; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005260:Female; D005313:Fetal Death / Q000196:embryology; D005327:Fetal Resorption / Q000196:embryology; D006801:Humans; D008607:Intellectual Disability / Q000196:embryology; D008274:Magnesium / Q000008:administration & dosage; D008275:Magnesium Deficiency / Q000196:embryology*; D051379:Mice; D009622:Noise / Q000009:adverse effects*; D011247:Pregnancy; D051381:Rats
D008274:Magnesium