Ethanol induces a transient susceptibility to audiogenic seizures in weanling C57BL/6J mice.
An acute dose of 5 g/kg ethanol led to a transient few days of a low incidence of susceptibility to audiogenic seizures in C57BL/6J mice (normally not susceptible) if the ethanol was administered during the transition from suckling to dietary self-sufficiency. This demonstrates a critical period of responsiveness to ethanol, shows ethanol-induced audiogenic priming, and may provide evidence for an indirect effect of ethanol on the brain.
D000161:Acoustic Stimulation; D000818:Animals; D001921:Brain / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D012640:Seizures / Q000139:chemically induced*; D014886:Weaning
D000431:Ethanol