Effects of hypnotics on memory.
The influence on memory of 7.5 mg zopiclone, given in single and repeated doses was compared with that of 2 mg flunitrazepam, 5 mg nitrazepam and placebo. Compared with placebo, all three drugs induced some impairment of memory especially after the first day of administration. Effects were more pronounced for the two benzodiazepines and more marked for flunitrazepam. There was one report of an anterograde amnestic episode after flunitrazepam.
D000328:Adult; D053961:Azabicyclo Compounds; D004311:Double-Blind Method; D005260:Female; D005445:Flunitrazepam / Q000494:pharmacology; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D009483:Neuropsychological Tests; D009567:Nitrazepam / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology*; D011897:Random Allocation
D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D010879:Piperazines; C515050:zopiclone; D005445:Flunitrazepam; D009567:Nitrazepam