title: [Effect of phenazepam on sleep cycles in rats].
abstract: It has been shown in experiments on rats that a single administration of phenazepam in doses of 0.5 and 2 mg/kg reduces the period of falling asleep and of being conscious, shortens the duration of the paradoxical sleep phase and increases the duration of slow-wave sleep thereby indicating the intensity of the drug hypnotic effect. Prolonged (10 days) administration of phenazepam does not induce tolerance. However, after the drug discontinuation there develops a withdrawal syndrome that is characterised by changes in the sleep structure.
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000009:adverse effects / Q000494:pharmacology*; D004361:Drug Tolerance; D006801:Humans; D008297:Male; D051381:Rats; D012890:Sleep / Q000187:drug effects*; D012894:Sleep Stages / Q000187:drug effects; D012893:Sleep Wake Disorders / Q000139:chemically induced; D013375:Substance Withdrawal Syndrome / Q000209:etiology
chemical_list: D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam
vernacular_title: Vliianie fenazepama on sleep cycles in rats.