Serological Investigation of the possibility of congenital transmission of papovavirus JC.
In an examination of paired sera from pregnant women, 9 of 57 women who had JC virus antibodies in their first specimens exhibited virus reactivation, as judged by a fourfold or greater rise in JC virus hemagglutination-inhibiting antibodies; 43 women remained seronegative through pregnancy. JC virus-specific immunoglobulin M was not demonstrated in umbilical cord sera of six infants born to mothers showing reactivation or in 300 additional umbilical cord sera from normal pregnancies.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007231:Infant, Newborn; D027383:Papillomaviridae / Q000276:immunology*; D027382:Polyomaviridae; D011247:Pregnancy; D014412:Tumor Virus Infections / Q000151:congenital* / Q000635:transmission
D000914:Antibodies, Viral; D007075:Immunoglobulin M