title: Effects of experimental atherosclerosis on cerebral blood flow in rabbits. Reversal by sorbinicate.
abstract: The present investigations were performed in conscious rabbits with the aim of determining the effects of an atherogenic diet (AD) on the cerebral blood flow (CBF) and of a nicotinic acid derivative (SN) on the CBF alterations induced by the diet. Experimental atherosclerosis reduces the blood flow in the rapidly exchanging cerebrovascular compartment; SN largely counteracts this effect. The experimental data suggest that the effect of this antiatherogenic drug is not due to vasoactive properties.
mesh_terms: D000818:Animals; D001158:Arteries / Q000378:metabolism; D001161:Arteriosclerosis / Q000378:metabolism / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008297:Male; D009539:Nicotinic Acids / Q000494:pharmacology*; D011817:Rabbits; D013012:Sorbitol / Q000031:analogs & derivatives* / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
chemical_list: D000960:Hypolipidemic Agents; D009539:Nicotinic Acids; D014280:Triglycerides; C015238:glucitol hexanicotinate; D013012:Sorbitol; D002784:Cholesterol