Effect of carbohydrates on the antibacterial activity of patulin on Streptococcus bovis.
The antibiotic activity of patulin on Streptococcus bovis varied in the presence of different sugars in the incubation medium. The 50% inhibitory concentration (IC50) of patulin was 4.5 times greater in the medium containing glucose than in the lactose-containing medium (100.5 versus 22 micrograms/mL). The addition of two sugars (glucose plus lactose) to the medium was followed by the utilization of glucose only when patulin was present; lack of growth on lactose was not due to beta-galactosidase inactivation by patulin.
D002241:Carbohydrates / Q000494:pharmacology*; D003470:Culture Media; D004352:Drug Resistance, Microbial / Q000187:drug effects; D005947:Glucose / Q000494:pharmacology; D007785:Lactose / Q000494:pharmacology; D010365:Patulin / Q000494:pharmacology*; D011714:Pyrans / Q000494:pharmacology*; D013291:Streptococcus / Q000187:drug effects* / Q000254:growth & development
D002241:Carbohydrates; D003470:Culture Media; D011714:Pyrans; D010365:Patulin; D005947:Glucose; D007785:Lactose