[Interactions between X-rays and antimitotic drugs: cellular effects (author's transl)].
The interactions between three drugs and X-rays were examined in rat hepatoma cells in vitro. Incubation with Daunomycine or 9-hydroxy ellipticine decreases the survival of both exponential and plateau phase cells, whereas cis-Pt (II) decreases the survival of plateau cells, especially irradiated in anoxia. The decrease in the Do was greater when the cells were incubated with the drugs prior to X-irradiation, and was greater in the case of plateau cells than in the case of exponential cells. The repair of potentially lethal damages was inhibited by these three compounds. However, the repair of sublethal damages was inhibited by cis-Pt II, but was modified neither by Daunomycine nor 9-hydroxy ellipticine.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects*; D002478:Cells, Cultured; D002945:Cisplatin / Q000494:pharmacology; D003630:Daunorubicin / Q000494:pharmacology; D004611:Ellipticines / Q000494:pharmacology; D011836:Radiation Tolerance; D051381:Rats
D000970:Antineoplastic Agents; D004611:Ellipticines; C008009:9-hydroxyellipticine; D002945:Cisplatin; D003630:Daunorubicin
Associations entre les radiations ionisantes et certains antimitotiques: effets au niveau cellulaire.