Further studies on anti-inflammatory activity of two potent indan-1-acetic acids.
The anti-inflammatory activity of 6-methoxyindan-1-acetic acid (1a) and 5,6-dimethoxyindan-1-acetic acid (1b) was evaluated in various acute, subacute and chronic models of inflammation. The results of these studies suggest that they have equal or slightly more anti-inflammatory activity than phenylbutazone, a standard anti-inflammatory drug. Of the two compounds, 5,6-dimethoxyindan-l-acetic acid appeared to be slightly more active than 6-methoxyindan-l-acetic acid.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000188:drug therapy; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D006099:Granuloma / Q000188:drug therapy / Q000209:etiology; D006614:Hindlimb; D007189:Indans / Q000627:therapeutic use*; D007192:Indenes / Q000627:therapeutic use*; D008297:Male; D010653:Phenylbutazone / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D007189:Indans; D007192:Indenes; C036583:6-methoxyindan-1-acetic acid; C036584:5,6-dimethoxyindan-1-acetic acid; D010653:Phenylbutazone