title: Estimation of the median lethal dose when responses within a little are correlated.
abstract: In the analysis of mortality experiments on neonatal animals, the presence of litter effects may prevent the use of probit analysis. This communication presents a method for estimating the median lethal dose, based on a modification of the beta-binomial distribution.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001947:Breeding; D005260:Female; D007928:Lethal Dose 50; D008098:Litter Size; D008954:Models, Biological; D011247:Pregnancy