[Effect of substances of a polypeptide nature isolated from the thymus and cerebral cortex on the primary immune response of mice to thymus-dependent and thymus-independent antigen].
The study of the effect of low molecular polypeptides on the primary immune response induced in CBA mice by the injection of thymus-dependent antigen (SRBC) and thymus-independent Vi-antigen showed that the injection of the preparation obtained from the cerebral cortex (cortexin) or the thymus (thymarin) for 5 days before and for 3 days after SRBc immunization stimulated the production of both direct (IgM) and indirect (IgG) antibody-producing cells, as well as the production of hemagglutinins. At the same time the production of antibody-producing cells and antibodies to Vi-antigen was suppressed. The preparations of white cerebral tissue and red bone marrow produced no effect on immune response in the animals.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects; D000942:Antigens, Bacterial / Q000276:immunology; D001853:Bone Marrow / Q000032:analysis*; D002540:Cerebral Cortex / Q000032:analysis*; D004912:Erythrocytes / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010455:Peptides / Q000494:pharmacology*; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000032:analysis* / Q000276:immunology*
D000942:Antigens, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010455:Peptides
Vliianie veshchestv polipeptidnoĭ prirody, vydelennykh iz timusa i kory golovnogo mozga, na pervichnyĭ immunnyĭ otvet u mysheĭ k timuszavisimomu i timusnezavisimomu antigenu.