Effect of perfluorochemicals on BCNU chemotherapy: preliminary study in a rat brain tumor model.
This preliminary study was undertaken to identify the combined efficacy of perfluorochemicals (Fluosol-43) and a chemotherapeutic agent (BCNU) in a rat brain tumor model. The brain tumor model was produced by the intracerebral transplantation of C6 rat glioma cells. Fluosol-43 plus BCNU in an oxygen environment produced a significant prolongation of mean survival time compared to that of BCNU treatment alone. Perfluorochemicals (Fluosol-43) seem to have some synergistic effect on BCNU chemotherapy for this brain tumor model.
D000818:Animals; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002330:Carmustine / Q000627:therapeutic use*; D004338:Drug Combinations / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005466:Fluorocarbons / Q000008:administration & dosage*; D005910:Glioma / Q000188:drug therapy* / Q000473:pathology; D006895:Hydroxyethyl Starch Derivatives; D009336:Necrosis; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010952:Plasma Substitutes / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains
D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination; D002330:Carmustine