Monoamine oxidase inhibitory and CNS activities of some quinazolinones.
16 new compounds have been synthesised in the series of 3-aryl-2-(1'-aryl-piperazin-4'-yl-carboxamidomethyl)-mercapto-quinazolinones. The compounds showed interesting results in anticonvulsant, hypnotic and monoamine oxidase (MAO) inhibitory screenings and are non-toxic. SAR were evaluated.
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis; D008297:Male; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis*; D010424:Pentobarbital / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000138:chemical synthesis*; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects
D000927:Anticonvulsants; D006993:Hypnotics and Sedatives; D008996:Monoamine Oxidase Inhibitors; D011619:Psychotropic Drugs; D011799:Quinazolines; D010424:Pentobarbital