[Influence of procaine and nicotinoyl-procaine on primary cultures of cerebellum and kidney cells from neonatal rats (author's transl)].
A comparative study was performed on the influence of two similar tertiary amines, procaine and nicotinoyl-procaine, on isolated kidney and cerebellum cells in culture. Shortly after the addition of the test substances vesicles are found in the cells and the cells are more broadly attached to the underground. But the attachment of microfilaments is scarcely adhered. Daily addition of procaine or nicotinoyl-procaine, resp., to cell cultures leads to an increase of protein concentration and enzyme activities. Particularly organotypical enzymes are enhanced, as gamma-glutamyltransferase in kidney cells and creatine kinase in cerebellum cells.
D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D002531:Cerebellum / Q000166:cytology* / Q000187:drug effects / Q000201:enzymology; D007668:Kidney / Q000166:cytology* / Q000187:drug effects / Q000201:enzymology; D009539:Nicotinic Acids / Q000494:pharmacology; D011343:Procaine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014176:Protein Biosynthesis; D051381:Rats
D009539:Nicotinic Acids; C020778:nicotinoylprocaine; D011343:Procaine
Einfluss von Procain und Nicotinoyl-procain auf Primärkulturen von Kleinhirn- und Nierenzellen neonataler Ratten.