[GABA-ergic correlates of aggression and intraspecies sociability of mice subjected to isolation].
Experiments on isolated mice (CC57W males) have demonstrated that GABA antagonists (bicuculline, picrotoxin, thiosemicarbazide) increase the desocializing effects of isolation (enhance aggression and reduce intraspecies sociability), while GABA-positive drugs (muscimol, gamma-acetylenic GABA) within a certain dosage range diminish aggression and favour a temporary recovery of sociability. It is suggested that GABA deficiency in the CNS of isolated mice is a pathogenetic link responsible for the pathological behavior -- superaggression and hyper-reactivity.
D000374:Aggression / Q000187:drug effects / Q000502:physiology*; D000480:Alkynes; D000614:Aminocaproates / Q000494:pharmacology; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D006801:Humans; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009118:Muscimol / Q000494:pharmacology; D010852:Picrotoxin; D012663:Semicarbazides / Q000494:pharmacology; D012919:Social Behavior; D012934:Social Isolation; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D000480:Alkynes; D000614:Aminocaproates; D001640:Bicuculline; D009118:Muscimol; D010852:Picrotoxin; D012663:Semicarbazides; D005680:gamma-Aminobutyric Acid; C013785:4-amino-5-hexynoic acid; C005151:thiosemicarbazide
GAMK-ergicheskie korreliaty agressivnosti i vnutrividovoĭ obshchitel'nosti mysheĭ, podvergnutykh izoliatsii.