title: [Hygienic evaluation of the content of heavy metals (lead and copper) in cosmetic products].
abstract: Heavy metals /lead and copper/ content was studied in various cosmetic articles: creams and cleansing milk, shampoos, hair dyes, eye shadows, rouge, lipsticks, powders, fond de teint, tooth pastes. The method flame atom-absorption spectrometry with chelation and extraction was used for their determination. The subacute dermal toxicity on albino rats was studied with working doses: lead--1,10 and 100 mg/kg, and copper--5,50 and 500 mg/kg. The content of lead and copper was established to be low in the majority of the cosmetic articles studied /lead--to 2.08 mg/kg, copper--to 6,28 mg/kg/and only in some of the articles of decorative cosmetic, it is considerably higher /lead--to 41,1 mg/kg, copper--to 138,6 mg/kg. That is due to the inadequate purification of the initial raw materials or to the presence of copper-containing dyes in the composition of the respective cosmetic article. As a result from the toxicological and pathoanatomical studies the small doses /lead 1 mg/kg and copper 5 mg/kg are defined as ineffective, and the high doses--with a light biological effect. The maximum allowable concentration of lead is proposed to be--10 mg/kg, and copper--50 mg/kg as side /technical/ pollutants in the production of cosmetic articles.
mesh_terms: D000818:Animals; D003300:Copper / Q000032:analysis* / Q000633:toxicity; D003358:Cosmetics / Q000032:analysis* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000187:drug effects; D007854:Lead / Q000032:analysis* / Q000633:toxicity; D008099:Liver / Q000187:drug effects; D008452:Maximum Allowable Concentration; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013054:Spectrophotometry, Atomic; D013154:Spleen / Q000187:drug effects
chemical_list: D003358:Cosmetics; D007854:Lead; D003300:Copper
vernacular_title: Khigienno prouchvane na suderzhanieto na tezhki metali (olovo i med) v kozmetichni sredstva.