Effect of pargyline on hepatic glutathione levels in rats treated acutely and chronically with ethanol.
A single dose of pargyline severely depleted hepatic reduced glutathione (GSH) levels in the rat. Ethanol administration, acute or chronic, had no effect on hepatic GSH levels; nor did such administration exacerbate the pargyline mediated GSH depletion. However a single dose of ethanol given one hour after pargyline administration enhanced the rate of recovery of hepatic GSH.
D000437:Alcoholism / Q000378:metabolism; D000818:Animals; D004032:Diet; D000431:Ethanol / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010293:Pargyline / Q000494:pharmacology*; D051381:Rats
D000431:Ethanol; D010293:Pargyline; D005978:Glutathione