Toxicological studies on sodium 2,3-dimercaptopropane-1-sulfonate in the rat.
The toxicity of Na-2,3-dimercaptopropane-1-sulfonate (DMPS) was investigated in rats. The lethality after large i.p. doses is diminished by a factor of approx. 6 if a single dose is divided into several doses on consecutive days. Chronic treatment with 600 mumol DMPS/kg and day p.o. did bring about adverse effects except a reduction in Cu-concentration in some organs, especially in the kidneys, immediately after DMPS-treatment, which was normalized within 1 week. The offspring of DMPS treated female rats showed no abnormalities.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002614:Chelating Agents / Q000633:toxicity*; D003300:Copper / Q000378:metabolism; D004112:Dimercaprol / Q000633:toxicity*; D005260:Female; D005298:Fertility / Q000187:drug effects; D006128:Growth / Q000187:drug effects; D007928:Lethal Dose 50; D051381:Rats; D012737:Sex Factors; D013997:Time Factors; D015032:Zinc / Q000378:metabolism
D002614:Chelating Agents; D004112:Dimercaprol; D003300:Copper; D015032:Zinc