Chronic ethanol ingestion and glycogen metabolism in male and female rats.
Chronic ethanol ingestion decreased liver glycogen levels in both male and female rats; however plasma glucose was decreased only in males. The decreased levels of liver glycogen were related to increases of 42% and 122% in glycogen phosphorylase in males and females, respectively. Both a and b forms of phosphorylase were increased, but the b form was increased more than the a form. Phosphorylase phosphatase was found to be increased 75% and 267% in males and females, respectively. Studies using positive and negative phosphorylase effector molecules indicated that ethanol ingestion may have altered the structure of phosphorylase a and that the degree of alteration was sex related.
D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002110:Caffeine / Q000494:pharmacology; D005260:Female; D006003:Glycogen / Q000378:metabolism*; D006801:Humans; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D010765:Phosphorylase Phosphatase / Q000378:metabolism; D006005:Phosphorylases / Q000378:metabolism; D051381:Rats; D012737:Sex Factors
D001786:Blood Glucose; D008112:Liver Glycogen; D002110:Caffeine; D006003:Glycogen; D006005:Phosphorylases; D010765:Phosphorylase Phosphatase