Mechanism of DNA-histone crosslinks in UV-irradiated nuclei.
Mechanism of the DNA-histone crosslinks in UV-irradiated chicken erythrocyte nuclei has been investigated. It has been demonstrated that the major chemical reaction induced by irradiation of DNA-histone complexes is the crosslinking between lysine and thymine residues and subsequent transfer of thyminyl group from DNA to lysine residues of histones.
D000818:Animals; D002467:Cell Nucleus / Q000528:radiation effects*; D002645:Chickens; D004247:DNA / Q000097:blood / Q000528:radiation effects*; D003852:Deoxyribonucleoproteins / Q000528:radiation effects; D004912:Erythrocytes / Q000528:radiation effects*; D006657:Histones / Q000097:blood / Q000528:radiation effects*; D009707:Nucleosomes / Q000528:radiation effects; D014466:Ultraviolet Rays
D003852:Deoxyribonucleoproteins; D006657:Histones; D009707:Nucleosomes; D004247:DNA