Studies on the OA-6129 group of antibiotics, new carbapenem compounds. II. In vitro evaluation.
The OA-6129 group of antibiotics, new carbapenem compounds, had relatively potent antimicrobial activities against Gram-positive and Gram-negative bacteria. Synergism of compound OA-6129A in combination with conventional beta-lactam antibiotics was observed in antimicrobial activity against beta-lactamase producers such as Proteus vulgaris GN 76 and Citrobacter freundii GN 346. The new carbapenem compounds were slightly superior to PS-5 in stability to kidney homogenates of various animal species.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004285:Dogs; D004355:Drug Stability; D004357:Drug Synergism; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism; D008297:Male; D051379:Mice; D013845:Thienamycins / Q000378:metabolism / Q000494:pharmacology*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D013845:Thienamycins; C036497:OA 6129A