Genotoxic activity of the aminophenols as evidenced by the induction of sister chromatid exchanges.
1 Most hair dyes contain the structural isomers ortho-, meta- and para- aminophenol which were investigated concerning their ability to induce sister chromatid exchanges (SCE) in cultured human lymphocytes in vitro and in Chinese hamster bone marrow cells in vivo. 2 In vitro only ortho-aminophenol significantly induced SCE in a dose-dependent manner. 3 In vivo none of the structural isomers increased significantly the SCE frequency. 4 It is concluded that ortho-aminophenol is a weak directly acting compound which is detoxified during its metabolism.
D000627:Aminophenols / Q000009:adverse effects*; D000818:Animals; D006224:Cricetinae; D003412:Cricetulus; D003434:Crossing Over, Genetic / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D000627:Aminophenols