Rotational syndrome after central injection of C-terminal 7-peptide of cholecystokinin.
Intracerebroventricular (ICV) injections of sulfated C-terminal 7-peptide of cholecystokinin and its N-tert-butyloxycarbonyl-protected analog elicited rotational behavior (barrel rotations), accompanied by a distorted head and body position, lack of spontaneous motor activity other than rotations, characteristic limb flexion and extension and loss of some reflexes. When the unsulfated 7-peptide was ICV injected, none of the above symptoms was observed. The rotational syndrome described resembles the syndrome of acute unilateral labyrinthectomy. Since similar results have been reported following central injections of other peptides, however, it appears to be a non-specific, probably toxic effect.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002766:Cholecystokinin / Q000008:administration & dosage / Q000494:pharmacology*; D007758:Ear, Inner / Q000502:physiology; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D012018:Reflex / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects
D010446:Peptide Fragments; D002766:Cholecystokinin