title: Synergism of combined lithium-neuroleptic therapy: a double-blind, placebo-controlled case study.
abstract: The authors describe a longitudinal, placebo-controlled study of the response to drug treatment of a 62-year-old schizoaffective patient hospitalized for 40 years. While neither lithium nor a neuroleptic drug alone was effective, both drugs administered simultaneously led to the gradual extinction of a pronounced behavioral cycle and the disappearance of manifest psychosis. The authors suggest a synergistic interaction between the two drugs and stress the need for sustained trials of the combination in patients with similar behavioral cycles.
mesh_terms: D001714:Bipolar Disorder / Q000188:drug therapy; D004311:Double-Blind Method; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D008875:Middle Aged; D010640:Phenothiazines / Q000627:therapeutic use*; D012560:Schizophrenia, Catatonic / Q000188:drug therapy*
chemical_list: D010640:Phenothiazines; C100162:acetophenazine; D008094:Lithium