[Effect of gidifen on behavior and hemodynamic signs of an emotionally stressful reaction].
Gidifen (diphenylphosphinylacetic acid hydrazide) is an original Soviet tranquilizer. In doses of 120--150 mg/kg it restores central baroreflex regulation of the arterial pressure supressed during acute emotional-stress reaction in cats (confrontation with a dog). The drug has an antihypertensive action and reduces tachycardia caused by the emotional stress. It has a selective antiphobic and antiaggressive action and does not produce ataxia. Quantitative evaluation of behavior was performed during group interaction of animals according to the five-point system.
D000284:Administration, Oral; D000374:Aggression / Q000187:drug effects; D000818:Animals; D000959:Antihypertensive Agents; D001007:Anxiety / Q000188:drug therapy; D002415:Cats; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D009949:Orientation / Q000187:drug effects; D010721:Phosphinic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D011311:Pressoreceptors / Q000187:drug effects; D012018:Reflex / Q000187:drug effects; D013315:Stress, Psychological / Q000188:drug therapy*; D014149:Tranquilizing Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D010721:Phosphinic Acids; D014149:Tranquilizing Agents; C025175:gidifen
Vliianie gidifena na povedenie i gemodinamicheskie proiavleniia émotsional'no-stressovoĭ reaktsii.