Time course of apomorphine-induced circling behaviour after striatal dopamine receptor denervation.
The curve describing the time course of apomophine-induced circling behaviour in rats with a 6-hydroxydopamine-induced lesion of the nigrostriatal dopamine (DA) pathway was studied with a microcomputerized rotometer. Up to a 2-week interval after lesioning, the contralateral circling response was a single bell-shaped curve but this gradually became a double-peaked curve after 4-5 months. At this time the bell-shaped curve was, however, restored by haloperidol pretreatment. It is concluded that the response of striatal DA receptors was modified either by the lesion of another neuronal system and/or that the absence of DA nerve endings induced changes in the striatal DA receptor itself.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001519:Behavior / Q000187:drug effects*; D003342:Corpus Striatum / Q000502:physiology*; D003714:Denervation; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D009475:Neurons, Afferent / Q000502:physiology; D051381:Rats; D011954:Receptors, Dopamine / Q000502:physiology*; D013239:Stereotyped Behavior / Q000187:drug effects*; D013997:Time Factors
D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D006220:Haloperidol; D001058:Apomorphine