title: [Sensitivity of a strain of Schistosoma intercalatum from Loum (Cameroon) and is natural hybrid to treatment with praziquantel. Preliminary results].
abstract: At Loum, S. intercalatum infection still occurs in its pure form. The infection, however, is regressing while S. haematobium and hybrid forms between the two species are developing. A single oral dose of 2-cyclo-hexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-o ne(praziquantel, EMBAY 8440, Biltricide), 40 mg/kg body weight, is a very effective treatment of the disease. Forty days after treatment eggs no longer occurred in the faeces of ten children voiding S. intercalatum eggs in their stools before they were cured. Five children voiding hybrid bilharzia eggs in their urine were no longer passing eggs after treatment.
mesh_terms: D000293:Adolescent; D002163:Cameroon; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000627:therapeutic use*; D008297:Male; D011223:Praziquantel / Q000627:therapeutic use*; D012552:Schistosomiasis / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology
chemical_list: D007546:Isoquinolines; D011223:Praziquantel
vernacular_title: Etude de la sensibilité de la souche de Schistosoma intercalatum de Loum (Cameroun) et de son hybride naturel au traitement par le praziquantel. Résultats préliminaires.