Effects of lysine-vasopressin and 1-deamino-8-D-arginine-vasopressin on memory in healthy individuals and diabetes insipidus patients.
Central diabetes insipidus (DI) patients showed impairments in short- and long-term memory functions, but not in attention and concentration, as compared to healthy individuals. A single i.m. injection or sub-chronic intranasal administration of either lysine-vasopressin (LVP) or 1-deamino-8-D-arginine-vasopressin (DDAVP) normalized the disturbed memory functions in DI patients. These peptides also improved memory functions in healthy individuals.
D000281:Administration, Intranasal; D000328:Adult; D001127:Arginine Vasopressin / Q000494:pharmacology*; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000494:pharmacology*; D003919:Diabetes Insipidus / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008236:Lypressin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D008875:Middle Aged
D001127:Arginine Vasopressin; D008236:Lypressin; D003894:Deamino Arginine Vasopressin