title: Psorospermin, a new antileukemic xanthone from Psorospermum febrifugum.
abstract: An ethanolic extract of Psorospermum febrifugum was fractionated with antileukemic activity in vivo in the P388 lymphocytic leukemia in mice and in vitro in the KB cell culture system used as a guide. The new antileukemic xanthone psorospermin 1 was isolated, and its structure was elucidated. The chlorohydrin of O-methylpsorospermin 2 was also isolated after treatment of the fraction containing psorospermin chlorohydrin 6 with diazomethane. Psorospermin 1 was demonstrated to have significant antitumor activity in the P388 in vivo system as well as cytotoxicity against the KB in vitro system.
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D002294:Carcinoma, Squamous Cell; D002460:Cell Line; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D013058:Mass Spectrometry; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D009303:Nasopharyngeal Neoplasms; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010063:Ovum / Q000187:drug effects; D010946:Plants, Medicinal / Q000032:analysis*; D012617:Sea Urchins; D014966:Xanthenes / Q000302:isolation & purification* / Q000494:pharmacology; D044004:Xanthones
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014966:Xanthenes; D044004:Xanthones; C025543:psorospermin