Nucleoside synthons and unusual oligonucleotides.
The syntheses of oligonucleotides are generally performed using commercial nucleoside synthons. In certain cases, however, when rare nucleosides containing modified sugar moieties or aglycones are desired it is necessary to synthesize the individual nucleoside precursors. We now report, herein, data on the preparation of two different series of nucleoside synthons. The first concerns the preparation of some 2'-O-methylnucleosides and the second involves synthesis of xylofuranosyladenine analogs and the eventual preparation of 2',5'-(xyloA)3, a potential interferon mediator.
D008722:Methods; D009705:Nucleosides; D009841:Oligonucleotides / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
D009705:Nucleosides; D009841:Oligonucleotides