[Toxicity and cytostatic effect of PtCl2(NH3)2 after i. v. and i. t. injection (author's transl)].
In tumor bearing mice intratumoral injection of PtCl1(NH3)2-solution increases the cytostatic effect while decreasing its toxicity in comparison it i. v. injection. Intratumoral injections of water-in-oil emulsions of the platin-compound are less cytostatic but have a considerably lower toxicity.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000503:physiopathology*; D002455:Cell Division / Q000187:drug effects; D002945:Cisplatin / Q000008:administration & dosage / Q000633:toxicity*; D004655:Emulsions; D005260:Female; D007275:Injections, Intravenous; D051379:Mice
D004655:Emulsions; D002945:Cisplatin
Toxizität und cytostatische Wirkung von PtCl2(NH3)2 nach i. v. und intratumoraler Injektion.