title: The effects of tryptophan and manipulations of serotonergic receptors on tonic immobility in chickens.
abstract: The effects of serotonergic manipulations on tonic immobility (TI) were examined. Systemic injections of tryptophan enhanced TI duration. This effect was reversed by quipazine, a 5-HT receptor agonist, and p-chloroamphetamine, a 5-HT releaser. Separately, these drugs caused marked reductions in TI duration. Fenfluramine, which promotes 5-HT release, also reduced TI duration. The quipazine attenuation of TI was prevented by pretreatment with the 5-HT receptor blocker cinanserin. The results are discussed in terms of 5-HT receptor mechanisms and the raphe model of tonic immobility.
mesh_terms: D000818:Animals; D002375:Catalepsy / Q000378:metabolism; D002645:Chickens; D002928:Cinanserin / Q000494:pharmacology; D005277:Fenfluramine / Q000494:pharmacology; D006801:Humans; D007103:Immobilization / Q000187:drug effects*; D011814:Quipazine / Q000494:pharmacology; D011903:Raphe Nuclei / Q000187:drug effects / Q000378:metabolism; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*; D014364:Tryptophan / Q000494:pharmacology*; D010133:p-Chloroamphetamine / Q000494:pharmacology
chemical_list: D011985:Receptors, Serotonin; D005277:Fenfluramine; D011814:Quipazine; D010133:p-Chloroamphetamine; D014364:Tryptophan; D002928:Cinanserin