[Efficacy and pattern-valence of psychoergic drug / A new method of comparing drugs applied to identical patients in randomized order (author's transl)].
Psychoergic drugs are defined as equally effective if they produce equal proportions of positive reactions in a sample of N individuals where each individual is treated, in random sequence, with each of m drugs. Equally effective drugs are defined as equally valent if they exert equal effects (1) in the subsample of N1 individuals reacting on just 1 drug out of m(2) equally effective inthe subsample of N2 individuals reacting on 2 out of m drugs etc to the subsample of Nm-1 individuals reacting on m-1 out of m drugs. Indices of effectivity and of potency are proposed and tested for differences by suitable tests. Numerical procedure is illustrated by comparing 3 stimulants in N = 40 volunteers.
D004341:Drug Evaluation / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D011619:Psychotropic Drugs / Q000494:pharmacology* / Q000627:therapeutic use; D011897:Random Allocation; D012107:Research Design
D011619:Psychotropic Drugs
Wirksamkeit und Wertigkeit von Psychoenergetika. Eine neue Methode des Vergleichs von Arzneimitteln, die denselben Patienten in Zufallsfolge verabreicht wurden.