Midazolam as a sedative on regional anesthesia. Preliminary results.
Diazepam is widely used as a sedative for loco-regional anesthesia. The venous irritation and long duration of action and hangover may be a drawback. We compared 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a] [1,4]benzodiazepine (midazolam, Ro 21-3981, Dormicum), a new water-soluble benzodiazepine, with diazepam for cardio-respiratory changes, onset time, duration of action, amnesia and venous irritation after a single i.v. shot in loco-regional anesthesia.
D000765:Anesthesia, Conduction; D001569:Benzodiazepines / Q000009:adverse effects; D001794:Blood Pressure / Q000187:drug effects; D003975:Diazepam / Q000009:adverse effects; D006801:Humans; D006993:Hypnotics and Sedatives; D008568:Memory / Q000187:drug effects; D008874:Midazolam; D011229:Preanesthetic Medication; D011674:Pulse / Q000187:drug effects; D012119:Respiration / Q000187:drug effects
D006993:Hypnotics and Sedatives; D001569:Benzodiazepines; D003975:Diazepam; D008874:Midazolam