Intracortical 6-hydroxydopamine induced an asymmetrical behavioral response in the rat.
Doses of 6-hydroxydopamine (6-OHDA) from 1 to 6 microgram injected into the right frontal cortex of rats led to spontaneous hyperactivity beginning 1 week after injection and lasting throughout the 30-day postoperative period. Identical left hemispheric injections did not elicit hyperactivity until a dose of 6 microgram was reached. Biochemical assays revealed that 6-OHDA injected into either hemisphere caused approximately the same amount of depletion of norepinephrine. These results suggest that the neural asymmetry which leads to hyperactivity may be post-synaptic to the cortical noradrenergic terminals.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D007839:Functional Laterality; D006801:Humans; D006892:Hydroxydopamines / Q000494:pharmacology*; D006948:Hyperkinesis / Q000139:chemically induced*; D007700:Kinetics; D008125:Locus Coeruleus / Q000187:drug effects / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats
D006892:Hydroxydopamines