Effect of cytostatics administration in rats on leukocyte cytochemical markers.
The influence of cytostatic drugs (busulphan, chlorambucil, prednisone, 6-mercaptopurine, L-asparaginase) on the activity of alkaline and acid phosphatase, alpha-naphtolacetate esterase and the content of glycogen and lipids in leukocytes of peripheral blood in healthy rats was investigated. No analogy was reported between the changes of cytochemical reactions in healthy population of leukocytes in rats as compared with the changes (observed in preceding papers) of cytochemical reactions in leukocytes of patients with leukemia under the influence of the same cytostatic drugs.
D000135:Acid Phosphatase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001215:Asparaginase / Q000494:pharmacology; D002066:Busulfan / Q000008:administration & dosage; D002699:Chlorambucil / Q000494:pharmacology; D005260:Female; D006003:Glycogen / Q000097:blood; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism*; D008055:Lipids / Q000097:blood; D008297:Male; D015122:Mercaptopurine / Q000494:pharmacology; D009283:Naphthol AS D Esterase / Q000097:blood; D009284:Naphthols; D011241:Prednisone / Q000494:pharmacology; D051381:Rats
D000970:Antineoplastic Agents; D008055:Lipids; D009284:Naphthols; D002699:Chlorambucil; D006003:Glycogen; D015122:Mercaptopurine; D009283:Naphthol AS D Esterase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D001215:Asparaginase; D002066:Busulfan; D011241:Prednisone