[Immunosupressant activity of direct and indirect acting anticoagulants].
Indirect action anticoagulants, when injected into (CBA--C57BL) F1 mice in doses commensurable with human therapeutic doses, produced different immunotropic effects: acenocoumarin and pelentan had no influence on the formation of immune response, whereas omephin showed a considerable stimulating effect on this process. Large doses of acenocoumarin, pelentan and omephin inhibited the formation of immune response if the antigen was introduced immediately after the injection of the anticoagulant. The immunosuppressing action of pelentan was particularly pronounced. Heparin suppressed the formation of immune responsèe both in imediate and delayed immunization. In immediate immunization the immunosuppresing action of heparin and pelentan injected simultaneously was weaker than the action of heparin alone. Small doses of pelentan haod no influence on the remote effect of heparin, whereas large doses of pelentan abolished the immunosuppressing action of heparin in delayed immunization.
D000074:Acenocoumarol / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects; D000925:Anticoagulants / Q000494:pharmacology*; D004347:Drug Interactions; D005017:Ethyl Biscoumacetate / Q000494:pharmacology; D006493:Heparin / Q000494:pharmacology; D006824:Hybridization, Genetic; D007111:Immunity, Cellular / Q000187:drug effects*; D007166:Immunosuppressive Agents; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010630:Phenindione / Q000031:analogs & derivatives / Q000494:pharmacology; D012397:Rosette Formation; D013154:Spleen / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects
D000925:Anticoagulants; D007166:Immunosuppressive Agents; D005017:Ethyl Biscoumacetate; C005418:omephine; D010630:Phenindione; D006493:Heparin; D000074:Acenocoumarol
Immunodepressornaia aktivnost' antikoaguliantov priamogo i nepriamogo deĭstviia.