Metabolism of fentiazac.
The main metabolite of 2-phenyl-4-p-chlorophenylthiazol-5-ylacetic acid (fentiazac) is represented by a p-hydroxylated compound which is formed rapidly and that, still 72 later, can be detected in the general circulation. The p-hydroxylated metabolite is much less toxic than the original molecule from which it derives, being still active from an anti-inflammatory standpoint (its activity being equal to 70--75% of that of fentiazac). The metabolite, which possesses a therapeutic index much higher than that of fentiazac, represents quite an important step in the detoxication processes of the drug and enhances the therapeutic activity of the drug itself.
D000085:Acetates / Q000138:chemical synthesis / Q000378:metabolism*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000378:metabolism*; D001711:Biotransformation; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004285:Dogs; D005260:Female; D008252:Macaca fascicularis; D008297:Male; D051381:Rats; D013844:Thiazoles / Q000138:chemical synthesis / Q000378:metabolism*
D000085:Acetates; D000893:Anti-Inflammatory Agents; D013844:Thiazoles; C006124:fentiazac