Disseminated Trichosporon infection. Occurrence in an immunosuppressed patient with chronic active hepatitis.
A 62-year-old woman with chronic active hepatitis receiving immunosuppressive drugs was initially admitted with sepsis secondary to an intra-abdominal abscess caused by Klebsiella pneumoniae. She had a stormy course despite adequate antimicrobial therapy. Her postoperative course was further complicated by a fungal infection. Blood, urine, and sputum cultures were positive for Trichosporon. Antifungal therapy was given but her condition deteriorated and she died. At autopsy, a disseminated fungal infection was found. Diagnosis and management of such infections in the immunosuppressed host are difficult.
D001379:Azathioprine / Q000627:therapeutic use; D002908:Chronic Disease; D005260:Female; D006505:Hepatitis / Q000188:drug therapy; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D008875:Middle Aged; D003904:Mitosporic Fungi; D009181:Mycoses / Q000175:diagnosis / Q000209:etiology*; D011241:Prednisone / Q000627:therapeutic use
D001379:Azathioprine; D011241:Prednisone