Prostaglandin E1 influx across mucosal membrane of mammalian intestine.
The influx of prostaglandin E1 (PGE1) across the mucosal membrane of mammalian intestinal cells was examined. Our results suggest that: (1) the mechanism of PGE1 influx across the mucosal membrane of mammalian intestinal cells is a carrier-mediated transfer process; (2) PGE1 influx into the intestinal cells is inhibited in the presence of 1 X 10(-4) M ouabain in the preincubation medium, and (3) PGE1 influx is dependent on the presence of sodium in the extracellular medium, and is altered by reversal of the sodium gradient that normally exists across the mucosal membrane.
D000527:Alprostadil; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D010042:Ouabain / Q000494:pharmacology; D011458:Prostaglandins E / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism
D011458:Prostaglandins E; D010042:Ouabain; D012964:Sodium; D000527:Alprostadil