The locomotor and stereotype response to dopaminergic drugs and caffeine after intracerebroventricular kainic acid in rats.
The effects of single kainic acid (KA) (0.1 microgram) intracerebroventricular injection on locomotor and stereotypy responses to amphetamine and apomorphine, and on locomotor response to caffeine were measured at different intervals (24, 120, 240, 480 h). The responses to amphetamine and caffeine were markedly elevated during the all period. In contrast, the responses to apomorphine remained unchanged. Histological examination showed severe destructions of neurons and fibres within the nucleus caudatus and the permanent loss of hippocampal pyramidal cells.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology*; D002421:Caudate Nucleus / Q000187:drug effects; D006801:Humans; D007276:Injections, Intraventricular; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects*
D011759:Pyrrolidines; D011954:Receptors, Dopamine; D002110:Caffeine; D000661:Amphetamine; D001058:Apomorphine; D007608:Kainic Acid