title: Comparison between pilocarpine and timolol on diurnal pressures in open-angle glaucoma.
abstract: In 14 eyes with open-angle glaucoma, 2% pilocarpine hydrochloride given four times a day was compared with timolol given twice daily in its effect on intraocular pressure around the clock. The findings suggest that the timolol produced a greater reduction in pressure than pilocarpine and that, in 50% of the diurnal curves, the timolol curve showed smaller swings in IOP.
mesh_terms: D002940:Circadian Rhythm; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D010862:Pilocarpine / Q000627:therapeutic use*; D011412:Propanolamines / Q000627:therapeutic use*; D013999:Timolol / Q000627:therapeutic use*
chemical_list: D011412:Propanolamines; D010862:Pilocarpine; D013999:Timolol