Kernicterus at low levels of serum bilirubin: the impact of bilirubin albumin-binding capacity. A 10-year retrospective survey.
A retrospective survey of neonatal post-mortems over a 10-year period was made to establish the incidence of kernicterus and the associated laboratory abnormalities. Cases with evidence of kernicterus without hyperbilirubinaemia were found to have significantly lower reserve albumin-binding capacity (RABC) than the control group. The results suggest that RABC estimation is a necessary adjunct in the assessment of the jaundiced, low birthweight neonate.
D001663:Bilirubin / Q000097:blood*; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007647:Kernicterus / Q000097:blood*; D008297:Male; D011247:Pregnancy; D011485:Protein Binding; D012189:Retrospective Studies; D012306:Risk; D012709:Serum Albumin / Q000378:metabolism*
D012709:Serum Albumin; D001663:Bilirubin