An experimental study of thiamine metabolism in acute ethanol intoxication.
A dose of 3.9 g/kg b.wt of ethanol was administered to rabbits, and ethanol and thiamine concentrations, transketolase activity and thiamine pyrophosphate (TPP) effect in blood samples were determined. It was established that ethanol ingestion produced a rapid decrease in blood thiamine levels and transketolase activity in erythrocytes and an increase in TPP effect in erythrocytes. These values reverted to normal within 2 or 3 days after the ingestion of alcohol.
D000435:Alcoholic Intoxication / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D008297:Male; D011817:Rabbits; D013831:Thiamine / Q000097:blood / Q000378:metabolism*; D013835:Thiamine Pyrophosphate / Q000097:blood; D014174:Transketolase / Q000097:blood
D001786:Blood Glucose; D014174:Transketolase; D013835:Thiamine Pyrophosphate; D013831:Thiamine