Structure-activity relationship of isatin Mannich bases and hydrazones.
35 isatin Mannich bases and hydrazones were tested fore their mitodepressant activity applying a phyto test with Lepidium sativum L. The obtained results were subjected to the Free-Wilson's analysis. Although calculated and experimentally determined mitodepressant activities differ considerably in some cases, there is a correlation (r = 0.94) between the studied structures and mitodepressant activities.
D000588:Amines / Q000494:pharmacology*; D006835:Hydrazones / Q000494:pharmacology*; D007211:Indoles / Q000494:pharmacology*; D007510:Isatin / Q000494:pharmacology*; D008352:Mannich Bases / Q000494:pharmacology*; D008938:Mitosis / Q000187:drug effects; D010944:Plants / Q000187:drug effects; D013329:Structure-Activity Relationship
D000588:Amines; D006835:Hydrazones; D007211:Indoles; D008352:Mannich Bases; D007510:Isatin