title: Some observations on the release of extrinsic and intrinsic plasminogen activators during exercise in man.
abstract: Exercise was found to cause the release of 'extrinsic' plasminogen activators into the bloodstream. The 'intrinsic' plasma plasminogen activators were not significantly altered although factor VIII clotting activity and, to a lesser extent, its related antigen were both raised. A small amount of systemic fibrin(-ogen)olysis was indicated by the generation of fragment X and a slight reduction in the amount of intact A alpha-fibrinogen chain present. Plasminogen and antiplasmins were not significantly affected by exercise. We conclude that exercise-induced fibrinolysis is brought about solely by the release of plasminogen activators(s) from the vessel wall but that this enhanced level of fibrinolysis is insufficient to produce a marked degree of systemic fibrin(ogen) breakdown.
mesh_terms: D000328:Adult; D005080:Exercise Test; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D005082:Physical Exertion; D010960:Plasminogen Activators / Q000097:blood*
chemical_list: D005340:Fibrinogen; D010960:Plasminogen Activators