Effects of platinum antitumor agents on in vitro assays of human antitumor immunity. II. Effects of cis-[Pt(NH3)2Cl2] on spontaneous cell-mediated cytotoxicity.
The effects of cis-[Pt(NH3)2Cl2] on the spontaneous cell-mediated cytotoxicity of human lymphoblast cell lines mediated by normal human peripheral blood lymphocytes was investigated. Direct addition of cis-[Pt(NH3)2Cl2], but not its tumor inactive trans isomer, to the in vitro spontaneous cytotoxicity assay resulted in a small but significant enhancement of target cell lysis. Pretreatment of target cell lines with 5 micro M cis-[Pt(NH3)2Cl2] also resulted in a similar increase in target cell susceptibility to lysis.
D002460:Cell Line; D002945:Cisplatin / Q000494:pharmacology*; D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D006801:Humans; D007113:Immunity, Innate; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000276:immunology
D002945:Cisplatin