The metabolism of cis-dichlorodiammineplatinum (II): distribution, clearance, and toxicity.
The distribution and toxicity of 195mPt-labeled cis-platinum were studied in two groups of dogs. Serum and tissue levels, renal and marrow toxicities, and urinary excretion were compared in dogs given cis-platinum, 3 mg/kg, intravenously with a group treated by intraperitoneal administration. Peak serum levels occurred immediately after intravenous administration and 8 hours after intraperitoneal instillation, at which time the two were identical and declined at similar rates. Mean levels of cis-platinum measured in peritoneal tissues on day 4 were higher in the intraperitoneal group. Blood urea nitrogen, creatinine, and white blood cell and platelet counts were similar in both groups. Bloody ascites and adhesion formation occurred in 37.5% of dogs treated by intraperitoneal administration. The intraperitoneal route of chemotherapy administration results in higher drug levels in target peritoneal tissues without a corresponding increase in systemic toxicity.
D000818:Animals; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism*; D004285:Dogs; D005260:Female; D006207:Half-Life; D006801:Humans; D014018:Tissue Distribution
D002945:Cisplatin