[Contribution to the analysis of the hypoglycaemic agent tolbutamide. Part 2 (author's transl)].
The chemical identification reaction for tolbutamide (USP 1975) involves its hydrolysis by sulphuric acid with the formation of n-butylamine. This amine then reacts with diazotised p-nitraniline to give 8 red or yellow coloured compounds. A radicalic and an ionic mechanism for their formation, which are partially interrelated, are discussed. Other oral sulphonamide-hypoglycaemic agents give a positive result with this identification reaction.
D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D006868:Hydrolysis; D007202:Indicators and Reagents; D014044:Tolbutamide / Q000032:analysis*
D007202:Indicators and Reagents; D014044:Tolbutamide
Zur Analytik des oralen Antidiabetikums Tolbutamid. 2. Mitteilung.