Attenuation by arginine- and desglycinamide-lysine-vasopressin of a centrally evoked pressor response.
Arginine8-vasopressin (AVP) administered in a lateral cerebral ventricle attenuated the pressor response evoked by electrical stimulation of the mesencephalic reticular formation (MRF) in urethane-anesthetized rats. The blockade appeared to be dose-dependent in the range of 3-25 ng. The maximal effect was a 40% reduction of the pressor response. Desglycinamide9-lysine8-vasopressin (DG-LVP) exerted a similar effect on the pressor response. Both AVP and DG-LVP failed to affect basal blood pressure upon intraventricular administration. It is suggested that centrally acting neuropeptides related to vasopressin affect brain mechanisms involved in the regulation of blood pressure.
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D006339:Heart Rate / Q000187:drug effects; D007276:Injections, Intraventricular; D008236:Lypressin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008636:Mesencephalon / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012154:Reticular Formation / Q000187:drug effects*
D001127:Arginine Vasopressin; C000879:vasopressin, 9-des-Gly-NH(2)-Lys-; D008236:Lypressin