[Influence of acemetacin on DNA repair and DNA synthesis in vitro and in vivo (author's transl)].
The effects of [1-(p-chlorobenzoyl)-5-methoxy-2-methyl-indole-3-acetoxy]-acetic acid (acemetacin, TV 1322, Rantudil) on DNA repair (unscheduled DNA synthesis) and semiconservative DNA synthesis have been investigated in vitro in mouse spleen cells and in vivo in human leukocytes. Quantitative determination of DNA repair was made possible by a computer program and additional measurement of parameters of uptake kinetics. in vitro results showed no influence on DNA synthesis and therapeutically relevant concentrations had no influence on DNA repair. 6 female patients with diagnosticized rheumatoid arthritis received acemetacin 4 x 30 mg daily for three months. During the duration of treatment there was no significant change in DNA repair capacity or in semiconservative DNA synthesis in comparison to pre-treatment values.
D000328:Adult; D000368:Aged; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001172:Arthritis, Rheumatoid / Q000378:metabolism; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D004260:DNA Repair / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007210:Indoleacetic Acids / Q000494:pharmacology*; D007213:Indomethacin / Q000031:analogs & derivatives*; D008297:Male; D051379:Mice; D008875:Middle Aged; D013154:Spleen / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D007210:Indoleacetic Acids; C026784:acemetacin; D004247:DNA; D007213:Indomethacin
Untersuchungen über die Beeinflussung von DNS-Reparatur und DNS-Synthese durch Acemetacin in vitro und in vivo.