Suppression of drinking and induction of sedation by a dopamine agonist is blocked by small doses of spiperone.
ET 495 (piribedil) produced significant hypodipsia in thirsty rats at 5 and 20 mg . kg-1, the effect being greater at the lower dose. At 5 mg . kg-1 ET 495 also induced a significant sedating effect, a characteristic of small doses of dopamine agonists. Both the hypodipsic and sedating effects of ET 495 were completely reversed by pretreatment with spiperone. The slight hypodipsia produced at 20 mg . kg-1 was accompanied by signs of low intensity behavioural stereotypy. The stereotypy, unlike the other behavioural effects of ET 495 treatment, was not antagonized by spiperone pretreatment.
D000818:Animals; D002090:Butyrophenones / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology; D004326:Drinking / Q000187:drug effects*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000037:antagonists & inhibitors*; D008297:Male; D010879:Piperazines / Q000037:antagonists & inhibitors*; D010891:Piribedil / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013134:Spiperone / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects
D002090:Butyrophenones; D006993:Hypnotics and Sedatives; D010879:Piperazines; D013134:Spiperone; D010891:Piribedil; D003913:Dextroamphetamine