Familial clustering of nasopharyngeal carcinoma.
Unusual clustering of nasopharyngeal carcinoma is reported among four Caucasian siblings, two of them twins. Clinical and histologic features appeared to be quite similar and three of them were discovered within a few months of each other. Peculiar aspects of racial and geographical distribution and possible role of genetic and environmental factors in the etiology of this relatively uncommon tumor are briefly discussed.
D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D011247:Pregnancy; D014429:Twins, Dizygotic