Chromosome changes in lymphocytes after occupational exposure to toluene.
Cytogenetic analyses were carried out in peripheral lymphocytes from 20 male workers exposed only to toluene in a rotogravure plant for more than 16 years. As compared with a group of 24 unexposed controls, significantly higher yields of chromatid breaks, chromatid exchanges and gaps were observed. The number of SCEs was significantly increased in smoking and non-smoking toluene-exposed workers compared with the corresponding control groups.
D002617:Chemical Industry; D002869:Chromosome Aberrations; D003434:Crossing Over, Genetic / Q000187:drug effects*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D014050:Toluene / Q000009:adverse effects* / Q000494:pharmacology
D009153:Mutagens; D014050:Toluene