Craniofacial resection following chemotherapy.
A patient with intracranial extension of an ethmoidal carcinoma is reported. Since the tumor progressed in size despite conventional radiation and chemotherapy, the patient was treated with Cis-dichlorodiamine platinum). Significant regression in the intracranial component was noted, thus allowing complete excision of the tumor through a craniofacial approach. Preoperative chemotherapy with this agent may have a role in the management of patients with paranasal sinus carcinoma if intracranial extension is present.
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery; D000328:Adult; D002945:Cisplatin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008722:Methods; D010255:Paranasal Sinus Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery*; D011300:Preoperative Care; D014057:Tomography, X-Ray Computed
D002945:Cisplatin