title: [Possibilities of immunostimulation in oncology. I. In vitro functional activity of rat peritoneal macrophages in presence of tranexamic acid].
abstract: Peritoneal macrophages from Wistar rats were examined in vitro to evaluate the effects of tranexamic acid on their spreading activity. The results suggested that some concentrations of the drug (10(-5), 10(-6)) may activate in vitro the function of the peritoneal adherent cells. This finding support the concept that tranexamic acid enhances host resistance by a mechanism to be elucidated.
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology*; D002478:Cells, Cultured; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D009369:Neoplasms / Q000188:drug therapy; D051381:Rats; D014148:Tranexamic Acid / Q000494:pharmacology*
chemical_list: D000276:Adjuvants, Immunologic; D003509:Cyclohexanecarboxylic Acids; D014148:Tranexamic Acid
vernacular_title: Possibilità di immunostimolazione in oncologia. i) Attività funzionale in vitro dei macrofagi peritoneali di ratto in presenza di acido tranexamico.