title: 5,7-Dihydroxytryptamine lesions of the amygdala reduce amphetamine- and apomorphine-induced stereotyped behaviour in the rat.
abstract: 5,7-Dihydroxytryptamine lesions directed towards the central nucleus of the amygdala produced an apparently selective and localised destruction of 5HT terminals within the amygdaloid complex, without damage to dopamine neurons. Such lesions attenuated the biting responses produced by both amphetamine and apomorphine, suggesting that 5HT within this area may play an important role in the mediation of these behavioural effects.
mesh_terms: D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology*; D000661:Amphetamine / Q000494:pharmacology*; D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001519:Behavior / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D004102:Dihydroxytryptamines / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D008297:Male; D009474:Neurons / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000502:physiology; D013239:Stereotyped Behavior / Q000187:drug effects*
chemical_list: D004102:Dihydroxytryptamines; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D000661:Amphetamine; D001058:Apomorphine; D004298:Dopamine