Cyanocycline A, a new antibiotic. Taxonomy of the producing organism, fermentation, isolation and characterization.
A new antibiotic, cyanocycline A, was isolated from the fermentation broth of Streptomyces flavogriseus strain No. 49, a soil isolate. The molecular formula of cyanocycline A was determined to be C22H26N4O5. The antibiotic has a cyano group and a N-heterocyclic quinone moiety in its structure. Cyanocycline A was found to have broad  spectrum antimicrobial and antitumor activity.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D003470:Culture Media; D004352:Drug Resistance, Microbial; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009287:Naphthyridines; D011809:Quinones / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000145:classification* / Q000378:metabolism / Q000502:physiology
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D003470:Culture Media; D009287:Naphthyridines; D011809:Quinones; C035070:cyanonaphthyridinomycin