[Changes in cells in the terminal portions of the pancreas following resection and administration of immunosuppressants].
Changes occurring in the terminal part cells of the white rat pancreas have been studied electron microscopically and historadioautographically in dynamics (3, 7, 15, 25 days) after its partial resection and after administration of immunodepressants (azathioprine and 6-mercaptopurine). At early stages of the experiment 6-mercaptopurine inhibits 3H-thymidine incorporation into the epithelial cell nuclei and decreases the number of mitotically dividing cells, azathioprine has less effect. After 15--25 days both preparations increase DNA synthesis; that is evident from increasing number of DNA-synthetising cells. Metabolism of sulphur-containing proteins in the terminal cells during the experiment demonstrates a certain tendency to increase; when 6-mercaptopurine is administered, intensity of 35S-methionine incorporation is increasing by the 7th day and when azathioprine is administered -- by the 15th day and remains at the dame levels during the successive periods.
D000818:Animals; D001345:Autoradiography; D001379:Azathioprine / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D008297:Male; D015122:Mercaptopurine / Q000494:pharmacology*; D008715:Methionine / Q000378:metabolism; D008854:Microscopy, Electron; D008940:Mitotic Index; D010179:Pancreas / Q000648:ultrastructure*; D010180:Pancreatectomy; D051381:Rats; D013936:Thymidine / Q000378:metabolism
D004247:DNA; D008715:Methionine; D015122:Mercaptopurine; D001379:Azathioprine; D013936:Thymidine
Izmeneniia v kletkakh kontsevykh otdelov podzheludochnoĭ zhelezy posle rezektsii i vvedeniia immunodepressorov.