title: [Effect of nifedipine on the ventricular diastolic stimulation threshold of the human heart].
abstract: The Ca-antagonist 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarbonic acid dimethylester (nifedipine) does not lead to an elevation of human myocardial stimulus-threshold in contrast to another injectable Ca-antagonist verapamil. There was no increase or decrease in bradycardiac arrhythmia in this study. Therefore beta-blockers and antiarrhythmic drugs given simultaneously will not have intolerable pharmacodynamic interaction with nifedipine in bathmotropic and bradycardiac arrhythmia.
mesh_terms: D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D004558:Electric Stimulation; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D014700:Verapamil / Q000494:pharmacology
chemical_list: D011725:Pyridines; D014700:Verapamil; D009543:Nifedipine
vernacular_title: Der Einfluss von Nifedipin auf die ventrikuläre diastolische Reizschwelle des menschlichen Herzens.