The origin of 1-(3-pyridyl-N-oxide)ethanol as a metabolite of 3-acetylpyridine.
1. 3-Acetylpyridine was metabolized extensively to 1-(3-pyridyl)ethanol when the hepatic enzyme source was the soluble fraction (140,000 g supernatant). 3-Acetylpyridine-N-oxide was identified as a metabolite using the 10,000 g or the microsomal fraction. 2. 1-(3-Pyridyl-N-oxide)ethanol was not detected as a metabolite of 1-(3-pyridyl)ethanol using tissue preparations. However, 3-acetylpyridine was formed in trace amounts when the alcohol was incubated with the 10,000 g or the microsomal fraction. 3. Incubation of 3-acetylpyridine-N-oxide with the soluble or 10,000 g fraction resulted in the formation of 1-(3-pyridyl-N-oxide)ethanol (keto-reduction) as the major metabolite. 3-Acetylpyridine was formed in trace amounts (N-oxide reduction) with the 10,000 g and the microsomal fractions.
D000818:Animals; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D006224:Cricetinae; D006168:Guinea Pigs; D008099:Liver / Q000378:metabolism*; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D010084:Oxidation-Reduction; D011725:Pyridines / Q000378:metabolism*; D011817:Rabbits; D051381:Rats
D011725:Pyridines; C010835:3-acetylpyridine; C027679:3-acetylpyridine N-oxide; C027678:1-(3-pyridyl-N-oxide)ethanol; C027680:1-(3-pyridyl)ethanol