[Murine near-diploid cell clones: a model for the genetic analysis of signs of transformation].
Several near-diploid clones were obtained from the established mouse cell line, CAK-7. These clones proved to be highly oncogenic in syngeneic irradiated mice (TD50 = 1 x 10(2)--2 x 10(3). They differed in plating efficiency in semi-solid medium (from 5 x 10(-3) to 22 x 10(-5)). There was no correlation between tumorigenicity of the cells and their plating efficiency in methylcellulose. The differences between clones able to form anchorage-independent clonies would permit their use for the genetic analysis of this kind of malignancy.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000648:ultrastructure*; D002999:Clone Cells / Q000528:radiation effects / Q000637:transplantation / Q000648:ultrastructure*; D004171:Diploidy; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D014185:Transplantation, Isogeneic
Klony okolodiploidnykh kletok myshi--model' dlia geneticheskogo analiza priznakov transformatsii.