Adenovirus type 5 induces progression of quiescent rat cells into S phase without polyamine accumulation.
Adenovirus type 5 induces cellular DNA synthesis and thymidine kinase in quiescent rat cells but does not induce ornithine decarboxylase. We now show that unlike serum, adenovirus type 5 fails to induce S-adenosylmethionine decarboxylase or polyamine accumulation. The inhibition by methylglyoxal bis(guanylhydrazone) of the induction of thymidine kinase by adenovirus type 5 is probably unrelated to its effects on polyamine biosynthesis. Thus, induction of cellular thymidine kinase and DNA replication by adenovirus type 5 is uncoupled from polyamine accumulation.
D000260:Adenoviruses, Human / Q000502:physiology*; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002453:Cell Cycle / Q000187:drug effects; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D004261:DNA Replication; D004790:Enzyme Induction / Q000187:drug effects; D008935:Mitoguazone / Q000494:pharmacology; D011073:Polyamines / Q000502:physiology*; D051381:Rats; D013937:Thymidine Kinase / Q000096:biosynthesis
D000956:Antigens, Viral; D011073:Polyamines; D013937:Thymidine Kinase; D008935:Mitoguazone