[1-Aroyl-5-nitrobenzotriazoles / 6th Communication: Antiinflammatory agents (author's transl)].
Based on the concept of the anellated heterocycle as the common structural characteristic of a series of antiinflammatory agents, 5-nitrobenzotriazole (1) was caused to react with cinnamoyl chloride (2a) and 4-fluorobenzoyl chloride (2b). The structure of the end products 1-cinnamoyl-5-nitrobenzotriazole (3a) and 1-(4-fluorobenzoyl)-5-nitrobenzotriazole (3b) is supported spectroscopically. 3a exhibits marked antiinflammatory activity.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D001169:Arthritis, Experimental / Q000188:drug therapy; D051381:Rats; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D014230:Triazoles
1-Aroyl-5-nitrobenzotriazole. 6. Mitteilung: Entzündungshemmende Wirkstoffe.