title: [Regional perfusion treatment in primary malignant melanomas of the extremities. (Microstage IV/V according to Clark and tumor thickness over 1.5 mm)].
abstract: During the period 1965-1976, 158 patients with stage I malignant melanoma of the extremities were treated by regional isolated perfusion with L-phenylalanine mustard (Melphalan) and local excision. In order to study local recurrence and survival, only patients with a primary melanoma Clark level IV or V and a tumor thickness of more than 1.5 mm were accepted in this study. The determinate survival in patients followed for 5-16 years is 74%; 20% developed positive regional lymph nodes. The local skin recurrence rate was 9% (14 patients); nine of these 14 patients simultaneously had distant metastases; the other five patients are alive with NED after retreatment. So far, this series of patients has shown no statistically significant difference in local recurrence after normothermic and hyperthermic perfusion: 2/19 (11%) and 12/132 (9%), respectively. However, mean tumor thickness in the patients treated by hyperthermic perfusion proved to exceed that in the normothermically perfused patients.
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D010478:Chemotherapy, Cancer, Regional Perfusion; D005121:Extremities; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D009364:Neoplasm Recurrence, Local; D012737:Sex Factors; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Regionale Perfusionbehandlung bei primären malignen Melanomen der Extremitäten. (Mikrostadien IV/V nach Clark und Tumordicke mehr als 1,5 mm).