Simplified technique to produce toxemia in the rat: considerations on cause of toxemia.
Under ether anesthesia a silver clip was placed around the abdominal aorta of pregnant rats, thus reducing the uterine blood flow by 35-45%. This resulted in a toxemia-like syndrome comparable to the one previously produced in other animal species. Consideration is given to the hypothesis that, in a similar way, compression of the abdominal aorta by the pregnant uterus in humans produces uterine ischemia leading to toxemia.
D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery; D001794:Blood Pressure; D003250:Constriction; D004727:Endothelium / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D007238:Infarction / Q000209:etiology; D008722:Methods; D009115:Muridae / Q000502:physiology*; D010920:Placenta / Q000098:blood supply; D011225:Pre-Eclampsia / Q000209:etiology* / Q000503:physiopathology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000209:etiology* / Q000503:physiopathology; D011507:Proteinuria / Q000503:physiopathology