Thioflavin T fluorescence in membranoproliferative glomerulonephritis.
Paraffin-embedded renal biopsy material from 50 cases of membranoproliferative glomerulonephritis (MPGN) was studied by thioflavin T staining and electron microscopy. Glomerular capillaries showed bright diffuse linear thioflavin T fluorescence in all cases of MPGN type 2 and also in some cases of MPGN types 1 and 3. This pattern of fluorescence appears to be related to the extent of intraglomerular deposits, rather than their location or nature.
D052160:Benzothiazoles; D001706:Biopsy; D005456:Fluorescent Dyes; D005921:Glomerulonephritis / Q000473:pathology*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D008854:Microscopy, Electron; D008856:Microscopy, Fluorescence / Q000379:methods*; D013844:Thiazoles
D052160:Benzothiazoles; D005456:Fluorescent Dyes; D013844:Thiazoles; C009462:thioflavin T