title: The effects of alloxan diabetes on Yucatan miniature swine and their progeny.
abstract: Alloxanization as a method to induce diabetes has been successfully undertaken in several laboratory animal models. The genetic transmissibility of the alloxan-diabetic condition has been investigated and confirmed by several studies in rodents. The Yucatan miniature pig is a potential laboratory animal model for diabetes. Studies were conducted to investigate the possibility that alloxan diabetes could be transmitted to subsequent generations in these animals. Diabetic pigs were produced directly with alloxanization, but the genetic transmissibility of this trait was not substantiated through the F2 generation. On the basis of these data, alloxan diabetes is not transmissible in Yucatan pigs in the same way that it is in rats.
mesh_terms: D000496:Alloxan; D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure; D002196:Capillaries / Q000648:ultrastructure; D003921:Diabetes Mellitus, Experimental / Q000235:genetics* / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013552:Swine; D013553:Swine Diseases / Q000235:genetics*
chemical_list: D000496:Alloxan