title: [Influence of Carbocromen on A-V-conduction and refractory period. Electrophysiological study with His-bundle-electrography in experimental animals (author's transl)].
abstract: The influence of 3-(2-diethylaminoethyl)-4-methyl-7-(carbethoxy-methoxy)-2-oxo-1,2-chromene-hydr ochloride (carbocromen, Intensaïn) on A-V-conduction and refractory period was studied by means of His-bundle-electrography on 12 anaesthetized cats. Immediately after application of carbocromen 6 mg/kg the A-H-conduction time was increased. In contrast to this, 12 mg/kg carbocromen caused significant prolongation of H-v interval. This study shows that carbocromen has effects on intraventricular conduction.
mesh_terms: D000818:Animals; D002036:Bundle of His / Q000187:drug effects; D002415:Cats; D002866:Chromonar / Q000494:pharmacology*; D003374:Coumarins / Q000494:pharmacology*; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects*; D008297:Male
chemical_list: D003374:Coumarins; D002866:Chromonar
vernacular_title: Einfluss von Carbocromen auf das Erregungsleitungssystem. Tierexperimentelle elektrophysiologische Studie mit dem His-Bündel-Elektrogram.