title: Relation of simple clotting tests to clotting factor levels in liver disease.
abstract: The prothrombin time with Manchester and ox thromboplastins, the 'P & P' test of Owren and Aas, the partial thromboplastin time, the thrombin time and assays for factors II, V, VII, VIII:C, IX and X were performed by one observer in 18 patients with liver disease and 27 normal subjects; the prothrombin time and partial thromboplastin time were also carried out on another 28 similar patients by various observers. Routine liver function tests were measured in all patients. The prothrombin time with Manchester thromboplastin was well correlated with other clotting tests, and performing the other tests did not add to the information. Discriminant function analysis confirmed that clotting tests did not distinguish between different types of liver disease. Correlations between clotting tests and liver function tests reflected liver cell damage but were also influenced by acute phase reactions.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D001779:Blood Coagulation Factors / Q000032:analysis* / Q000502:physiology; D001780:Blood Coagulation Tests; D006521:Hepatitis, Chronic / Q000097:blood / Q000175:diagnosis; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000175:diagnosis*; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D013918:Thrombin Time
chemical_list: D001779:Blood Coagulation Factors