title: Evaluation of the soluble fibrin monomer complexes and other coagulation parameters in obstetric patients.
abstract: The soluble fibrin monomer complexes (SFMC) in 154 obstetric patients with possible disseminated intravascular coagulation (DIC) were evaluated in SDS polyacrylamide gel electrophoresis (PAGE) after precipitation with B-alanine. Other coagulation tests were performed on these patients. The patients were classified into three groups: A) patients with a clinical history of DIC (6 cases); B) patients with only the analytical alterations of DIC (35 cases); and C) patients who showed pathological obstetric diagnoses but without a clinical nor analytical history of DIC (113 cases). In the three groups, well-defined bands of less electrophoretic mobility than fibrinogen were obtained. A significant increase in the second electrophoretic band was found in group A (5.1 per cent) when compared to group C (0.5 per cent). The second electrophoretic band appeared in greater proportion in the group of patients with an unfavorable clinical evolution.
mesh_terms: D000037:Abruptio Placentae / Q000209:etiology; D000941:Antigens / Q000032:analysis; D001780:Blood Coagulation Tests; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D004461:Eclampsia / Q000209:etiology; D004619:Embolism, Amniotic Fluid / Q000209:etiology; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D005340:Fibrinogen / Q000276:immunology; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood* / Q000175:diagnosis; D011379:Prognosis; D018805:Sepsis / Q000209:etiology; D014593:Uterine Inertia / Q000209:etiology
chemical_list: D000941:Antigens; D005338:Fibrin Fibrinogen Degradation Products; C011468:fibrinmonomer; D005340:Fibrinogen