title: Studies on the Ritter reaction. I. Synthesis of 3-/5-barbituryl/-propanesulfonic acids with anti-inflammatory activity.
abstract: Under the condition of the Ritter reaction the allyl group bound to C5 of the barbituric ring was observed to transform, due to addition of sulfuric acid, into beta-sulfooxy-propane-sulfonic or beta-hydroxy-propanesulfonic group. Inner anhydrides of the structure of beta-sulfone or carbyl sulfate are the intermediate products of these reactions. Well water-soluble calcium salts of the synthetized acids were pharmacologically analyzed.
mesh_terms: D000097:Acetonitriles; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D001463:Barbiturates / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D013451:Sulfonic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D013464:Sulfuric Acids
chemical_list: D000097:Acetonitriles; D000893:Anti-Inflammatory Agents; D001463:Barbiturates; D013451:Sulfonic Acids; D013464:Sulfuric Acids; C033158:sulfuric acid; C032159:acetonitrile