Do cholinomimetics specifically antagonize rotational behavior?
Asymmetries of body posture and movement (rotational behavior) following intracerebral application of dopamine (DA, 200 micrograms/2 microliters) or carbachol (30 and 60 micrograms/2 microliters) were diminished by systemically applied oxotremorine (0.5-1.0 mg/kg IP). The combined intracerebral injections of DA and carbachol show localization-specific effects in caudate nucleus, substantia nigra and globus pallidus. The experiments point to specific dopaminergic-cholinergic interaction in different brain regions. Systemically applied cholinomimetics exert a generally suppressive action on motoric effects.
D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D002421:Caudate Nucleus; D004298:Dopamine / Q000494:pharmacology; D005260:Female; D006801:Humans; D007267:Injections; D010095:Oxotremorine / Q000494:pharmacology; D010277:Parasympathomimetics / Q000494:pharmacology*; D011187:Posture; D051381:Rats; D011919:Rats, Inbred Strains; D012399:Rotation; D013239:Stereotyped Behavior / Q000187:drug effects*; D013378:Substantia Nigra
D010277:Parasympathomimetics; D010095:Oxotremorine; D002217:Carbachol; D004298:Dopamine