Effect of verapamil on ST-segment elevation evaluated by the orthogonal leads of the Frank vector system in patients with acute myocardial infarction.
The effect of i.v. verapamil (0.1 mg/kg) on myocardial ischemic injury was evaluated using the orthogonal leads of the Frank system in 10 selected patients with acute myocardial infarction admitted to the C.C.U. within 8 h from the onset of symptoms. The ST-vector magnitude (STVM) which remained stable over a 2-h control period was progressively and significantly reduced after verapamil administration (-21.1 +/- 5.3%, P < 0.02, 15 min after the injection; -36.5 +/- 6.8%, P < 0.01, after 120 min). Verapamil significantly lowered systemic blood pressure immediately after injection (from a mean value of 134 +/- 3/83 +/- 2 mmHg to 121 +/- 3/76 +/- 2 mmHg); the reduction of systolic blood pressure was effectively maintained through the whole experimental period, while heart rate and the product "heart rate x systolic blood pressure x 10(-3") were not significantly changed. The results are discussed in terms of a possible relationship between the reduction of STVM by verapamil and a reduction of the ischemic area.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology*; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology*
D014700:Verapamil