A new case of Pick's disease. Anatomical and ultrastructural studies.
The fine structure of a cortical frontal biopsy of Pick's disease is described. Pic bodies appear made of unbranched 120 A neurofilaments, sometimes clustered in geometrical pattern. Post-mortem examination, performed 8 years later, reveals typical lesions. The characteristics of Pick bodies are discussed.
D001344:Autopsy; D001706:Biopsy; D001921:Brain / Q000473:pathology / Q000648:ultrastructure; D003599:Cytoskeleton / Q000648:ultrastructure; D003704:Dementia / Q000473:pathology*; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged