title: The effects of an adhesive in the middle ear.
abstract: This study investigated the effects of enbucrilate (Histoacryl) on the middle ear. Small amounts of the adhesive were used in 81 middle-ear operations performed on 50 rabbits. Light microscopic investigation of these ears 1, 2, and 3 months after surgery showed bone necrosis and a granulation tissue reaction surrounded by foreign-body giant cells. Inner-ear changes were observed in a third of the cases. Therefore, enbucrilate should only be used with extreme care and in minute quantities and never near the labyrinthine capsule.
mesh_terms: D000818:Animals; D004429:Ear Ossicles / Q000187:drug effects; D004432:Ear, Middle / Q000187:drug effects*; D004659:Enbucrilate / Q000009:adverse effects*; D007249:Inflammation / Q000139:chemically induced; D010020:Osteonecrosis / Q000139:chemically induced; D011817:Rabbits
chemical_list: D004659:Enbucrilate