title: A possible role of linked Na and Cl movement in active Cl uptake in smooth muscle.
abstract: Smooth muscles actively accumulate Cl. Abolition of the transmembrane Na gradient has been shown to lead to a passive distribution of Cl. This suggested to us that Na and Cl may move together across the smooth muscle cell membrane, Cl accumulation resulting due to [Na]i being less than [Na]o. In favour of this view are the findings that Cl uptake is reduced in Na-free medium, Na uptake is reduced in Cl-free medium, reducing [Cl]i reduces Na efflux, and increasing [Na]i increases Cl efflux.
mesh_terms: D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002712:Chlorides / Q000378:metabolism* / Q000494:pharmacology; D003106:Colon / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D002712:Chlorides; D012964:Sodium