title: Decreased distensibility of a passive vascular bed in diabetes mellitus: an indicator of microangiopathy?
abstract: This study was undertaken to determine whether the distensibility of a passive vascular bed is reduced in Type 1 (insulin-dependent) diabetic patients with microangiopathy. The change in blood flow induced by 45 degrees head-up tilting was studied in two systems: (a) following maximal ischaemic exercise and (b) in a vascular bed locally paralysed by the injection of papaverine. Five normal subjects, six patients with long-standing Type 1 diabetes and six non-diabetic patients with severe atherosclerosis affecting the legs were studied. Blood flow was measured in the anterior tibial muscle by the isotope washout technique. The median increase in blood flow produced by tilting was greater in normal subjects than in diabetic subjects in both the locally-relaxed bed (58% and 14% respectively) and after maximal ischaemic exercise (45% and 4% respectively). In the atherosclerotic subjects, the increase in blood flow in the locally relaxed bed was 77%. The results are consistent with the hypothesis that the reduced distensibility seen in the diabetic subjects was related to the presence of microvascular disease and that the behaviour of a vascular bed relaxed by the local injection of papaverine might be an appropriate model to study this condition.
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002200:Capillary Resistance; D003925:Diabetic Angiopathies / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007866:Leg; D008297:Male; D009132:Muscles / Q000098:blood supply*; D010208:Papaverine / Q000494:pharmacology; D005082:Physical Exertion; D011187:Posture; D012039:Regional Blood Flow
chemical_list: D010208:Papaverine