Gastric emptying in patients with gastric ulcers--effects of oral and intramuscular administration of anticholinergic drug.
In our previous report on gastric emptying, we noted that delayed gastric emptying might be one of the etiological factors of gastric ulcers. Gastric emptying was measured using the acetaminophen method. The gastric emptying value was indicated as "microgram/ml", the acetaminophen concentration 45 min after test meal ingestion. In this study, the effects of an anticholinergic drug on gastric emptying were investigated in gastric ulcer patients. Oral and intramuscular administrations of butropium bromide (BB) were studied. The following results were obtained; 1. Oral administration of 10 and 15 mg of BB accelerated gastric emptying to a statistically significant degree (p less than 0.05), compared with the placebo in delayed gastric emptying cases in a dose-dependent manner (r = 0.978). 2. Intramuscular administration of small doses of BB (0.25 and 0.5 mg) also accelerated gastric emptying in delayed gastric emptying cases, but in general, intramuscular administration of BB (0.25-2.0 mg/person) inhibited gastric emptying in a dose dependent manner (r = -0.999). 3. Intramuscular administration of BB (0.25-2.0 mg/person) inhibited gastric emptying in a dose dependent manner in rapid gastric emptying cases (r = -0.977).
D000082:Acetaminophen; D000284:Administration, Oral; D000328:Adult; D001286:Atropine Derivatives / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D010276:Parasympatholytics / Q000627:therapeutic use; D010919:Placebos; D013276:Stomach Ulcer / Q000503:physiopathology* / Q000628:therapy
D001286:Atropine Derivatives; D010276:Parasympatholytics; D010919:Placebos; D000082:Acetaminophen; C006846:butoxybenzyl hyoscyamine