Facilitated shock-induced aggression after chronic treatment with antidepressant drugs in the rat.
The effects of four antidepressant drugs with different mechanisms of action on shock-induced fighting between pairs of rats were determined. Amitriptyline, imipramine, mianserin and iprindole, given chronically, facilitated fighting behavior.
D000374:Aggression / Q000187:drug effects*; D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D004597:Electroshock; D006801:Humans; D007099:Imipramine / Q000494:pharmacology; D007488:Iprindole / Q000494:pharmacology; D008297:Male; D008803:Mianserin / Q000494:pharmacology; D051381:Rats
D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline; D008803:Mianserin; D007488:Iprindole; D007099:Imipramine