Intensive plasma exchange--effects on haemostasis.
Our results show that 4L. plasma exchange with coagulation factor free fluids even when carried out on a daily basis for 7 or more days is a relatively safe procedure. Despite gross abnormalities of coagulation screening tests, and coagulation factor levels, spontaneous haemorrhagic incidents occur very rarely (5/815; 0.61%) and no thrombotic episodes were observed. Routine replacement with fresh frozen plasma is therefore not required to maintain normal haemostasis although prophylactic platelet concentrates would be advisable if the platelet count falls below 30 x 10(9)/1.
D000328:Adult; D000368:Aged; D001779:Blood Coagulation Factors / Q000032:analysis; D001780:Blood Coagulation Tests; D001783:Blood Flow Velocity; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006470:Hemorrhage / Q000209:etiology / Q000503:physiopathology; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D010953:Plasma Volume; D010974:Platelet Aggregation; D010976:Platelet Count; D013927:Thrombosis / Q000209:etiology / Q000503:physiopathology
D001779:Blood Coagulation Factors; D005340:Fibrinogen