[Oestrogen-induced proteins in breast cancer (author's transl)].
The hormone dependence and the prognosis of human breast cancers are currently based on assays of the estrogen receptor (RE) and progesterone receptor (RP) in the tumor. However, such prediction can not be fully accurate: RE may be non functional in some tumors and the estrogenic regulation of RP is not directly correlated with the effects of estrogens on cell growth. Here we described other estrogen induced intracellular, secreted or membrane proteins. Investigations of these proteins should allow a better understanding of the mechanisms by which estrogens stimulate the growth and spreading of breast cancer. Some secreted proteins could even be useful as circulatory markers of hormone dependence.
D001943:Breast Neoplasms / Q000378:metabolism*; D002460:Cell Line; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008565:Membrane Proteins / Q000096:biosynthesis; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D010960:Plasminogen Activators / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D013937:Thymidine Kinase / Q000378:metabolism
D008565:Membrane Proteins; D009363:Neoplasm Proteins; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D004958:Estradiol; D007770:L-Lactate Dehydrogenase; D013937:Thymidine Kinase; D004259:DNA-Directed DNA Polymerase; D010960:Plasminogen Activators
Protéines induites par les oestrogènes dans les cancers du sein.