Retinoids and the prevention of cervical dysplasias.
Women with abnormal cytology were matched with normal control subjects for age, parity, ethnicity, and socioeconomic class and participated in a blind case-control study focused on the role of nutrition in cervical dysplasia. Sucrose gradient ultracentrifugation studies for determination of the presence and concentration of the binding proteins for retinol and retinoic acid were performed on colposcopic biopsy tissue specimens. The nutritional survey revealed statistically significant differences for vitamins A and C and beta carotene. Retinol binding protein was absent or minimally detectable and inversely related to the severity of the dysplasia. It is proposed that a double-blind clinical trial be conducted to evaluate whether retinoids may pharmacologically inhibit, arrest, or reverse cervical dysplasia.
D001205:Ascorbic Acid / Q000378:metabolism*; D002278:Carcinoma in Situ / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D002338:Carotenoids / Q000378:metabolism; D004032:Diet; D005260:Female; D006801:Humans; D012177:Retinol-Binding Proteins / Q000378:metabolism; D014212:Tretinoin / Q000378:metabolism; D002578:Uterine Cervical Dysplasia / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000378:metabolism; D019207:beta Carotene
D012177:Retinol-Binding Proteins; D019207:beta Carotene; D014801:Vitamin A; D002338:Carotenoids; D014212:Tretinoin; D001205:Ascorbic Acid