Mutagenic action of structurally related alkene oxides on Schizosaccharomyces pombe: the influence, 'in vitro', of mouse-liver metabolizing system.
A series of aliphatic epoxides were tested for their ability to induce forward mutations in the yeast Schizosaccharomyces pombe. For all the compounds under study, a linear dose-response relationship was found, and the ranking of the relative specific activity was: epichlorohydrin greater than ethylene oxide greater than glycidol greater than 1,2-epoxybutane greater than 1,1,1-trichloropropylene oxide greater than propylene oxide greater than 2,3-epoxybutane. The influence of the metabolic conversion of the epoxides by the mouse-liver S9 fraction was also investigated. In such conditions, except for the 2,3-epoxybutane, the genetic activity of epoxides seems to be reduced.
D000818:Animals; D001711:Biotransformation; D004852:Epoxy Compounds / Q000494:pharmacology*; D004988:Ethers, Cyclic / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D012568:Schizosaccharomyces / Q000187:drug effects; D013329:Structure-Activity Relationship
D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D009153:Mutagens