Electrophysiological evidence for multiple sites of actions of angiotensin II for stimulating paraventricular neurosecretory cells in the rat.
Microelectrophoretically (MEPh) applied angiotensin II (AII) excited about half of the PV neurosecretory cells recorded. The excitation was blocked by MEPh applied Sar1-Ala8-AII. Intraventricular (IVT) injection of AII excited both the sensitive cells and insensitive cells to the MEPh applied AII. MEPh-applied Sar1-Ala8-AII, however, blocked the IVT AII induced excitation only in the former type of the cells.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D004553:Electric Conductivity; D004971:Estrus; D005260:Female; D007031:Hypothalamus / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000502:physiology*; D011247:Pregnancy; D011359:Proestrus; D051381:Rats
D000804:Angiotensin II