title: [Experimental study of sulpiride-bromocriptine association on the female rat estrous cycle (author's transl)].
abstract: The effects of joint treatment by sulpiride (1 mg . kg-1 S.C. pro die) and bromocriptine (3 mg . kg-1 S.C. pro die) on female rat estrous cycles were carried out on a group of ninety animals for a twenty-one days period. The results thus obtained show that: (i) bromocriptine alone does not disturb the estrous cycle, (ii) when given both with sulpiride, it prevents from this psycholeptic's estrous cycle blockade, (iii) finally, it leads to the regression of a blockade induced by an eight days sulpiride pretreatment. Therefore, it is likely that these two drugs act antagonistically at tuberoinfundibular dopaminergic receptors involved in the prolactin and gonadotropins release.
mesh_terms: D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D004347:Drug Interactions; D004971:Estrus / Q000187:drug effects*; D005260:Female; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013469:Sulpiride / Q000494:pharmacology*
chemical_list: D001971:Bromocriptine; D013469:Sulpiride
vernacular_title: Etude expérimentale de l'association sulpiride-bromocriptine sur le cycle oestral de la ratte.