Somatomedin C: restoration in vivo of cycle traverse in G0/G1 blocked cells of hypophysectomized animals.
DNA synthesis and mitosis in frog lens epithelium are abolished by hypophysectomy and restored by somatomedin C. Both growth hormone and triiodothyronine also restore lens cell proliferation in vivo but not in vitro. Somatomedin-like activity in frog serum is diminished by hypophysectomy and is restored by growth hormone and triiodothyronine.
D000818:Animals; D001001:Anura; D002453:Cell Cycle / Q000187:drug effects*; D004261:DNA Replication / Q000187:drug effects; D004847:Epithelial Cells; D013006:Growth Hormone / Q000494:pharmacology; D007016:Hypophysectomy; D007334:Insulin-Like Growth Factor I; D007399:Interphase / Q000187:drug effects; D007908:Lens, Crystalline / Q000166:cytology*; D008675:Metamorphosis, Biological; D008938:Mitosis / Q000187:drug effects; D013002:Somatomedins / Q000097:blood / Q000494:pharmacology*; D014284:Triiodothyronine / Q000494:pharmacology
D013002:Somatomedins; D014284:Triiodothyronine; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone