Experimental and clinical ventricular bypass during acute heart failure.
Mechanical support of the failing heart in the form of bypass of the left and right ventricles by roller pumps was used in 25 dogs with model cardiogenic shock. Early application of left ventricular bypass in acute heart failure normalizes the myocardial bioenergy state and promotes reversible changes in myocardial ultrastructure as demonstrated by an increased surface area of mitochondrial cristae. On the basis of hemodynamics and morphology, we conclude that pump-aided bypass of ventricles without synchronization is a simple and effective method of circulation assistance. Mechanical support duration from 1 to 138 hours has been used in 10 patients following corrective heart surgery.
D000208:Acute Disease; D000818:Animals; D001243:Assisted Circulation / Q000379:methods*; D002302:Cardiac Output; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D004285:Dogs; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D006352:Heart Ventricles / Q000503:physiopathology; D009206:Myocardium / Q000648:ultrastructure; D012770:Shock, Cardiogenic / Q000209:etiology / Q000503:physiopathology / Q000601:surgery