Plasma volume and plasma volume distribution at rest, during muscular work, cold pressure test and psychological stress in male offspring from families with heavy aggregation of hypertension.
Total and central plasma volume was measured in 51 male offspring of hypertensive individuals belonging to families with a history of essential hypertension for at least two generations. They were compared to 38 age-matched individuals without known hypertension in their families for at least two generations. Central plasma volume was determined at rest and during muscle work, cold pressure test and psychological stress. The offspring had significantly lower total plasma volume than the controls. Central plasma volume was equal in offspring and controls. The quotient central/total plasma volume was thus higher in offspring than in controls, and the difference was statistically significant during psychological stress and dynamic muscle work. Possible reasons for the differences between offspring and controls are an increased transcapillary escape of plasma, an increased quotient intracellular/extracellular fluid and/or increased tone of the capacitance vessels.
D000328:Adult; D003080:Cold Temperature; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D005082:Physical Exertion; D010953:Plasma Volume; D012146:Rest; D013315:Stress, Psychological / Q000503:physiopathology