Tumor imaging with radioactive metal chelates conjugated to monoclonal antibodies.
High-resolution gamma camera images of mouse erythroid tumors were obtained by use of leukemia cell-specific monoclonal antibodies labeled with bifunctional radioactive metal chelates. Small tumors (200 to 300 milligrams) were visible without subtraction or enhancement 1 to 5 hours after injection of antibody. Chelate-derivitized monoclonal antibodies permit targeting of a broad spectrum of radioisotopes, including those that are optimum for agamma for gamma camera imaging or positron tomography, as well as those that are tumoricidal.
D000818:Animals; D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D006023:Glycoproteins / Q000276:immunology; D007204:Indium; D007942:Leukemia, Experimental / Q000000981:diagnostic imaging*; D011868:Radioisotopes; D011877:Radionuclide Imaging; D011925:Rauscher Virus / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D006023:Glycoproteins; D011868:Radioisotopes; D014764:Viral Proteins; D007204:Indium