[Kinetic parameters of D(+)-glucose in epileptic children and under anticonvulsive therapy (author's transl)].
In 17 Children 5-14 years old, suffering from recurrent convulsive disorders the kinetic parameters of D(+)-glucose were determined before and after treatment. 20 children treated with different anticonvulsants for many years were included in the study, 11 children served as control group. The elimination half-life of glucose is significantly shorter (1.5 plus or minus 5,4 min) before treatment. After sufficient drug therapy the elimination half-life becomes normal (19.6 plus or minus 4.9 min). The glucose pool which is decreased before treatment normalizes when drugs are given. During long term treatment the glucose transfer (metabolisation rate) is increased when convulsions occur or abnormalities of the EEG are observed. Neither the duration of the treatment nor the kind of drugs seem to influence the kinetic parameters of glucose.
D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008433:Mathematics
D000927:Anticonvulsants; D001786:Blood Glucose; D005947:Glucose
Biokinetische Parameter der Glukoseelimination bei Kindern mit hirnorganischen Anfallsleiden unter dem Einfluss antikonvulsiver Therapie.