title: [The influence of food on the bioavailability of drugs on the example of sulfamethoxydiazine (author's transl)].
abstract: It is demonstrated that the bioavailability of sulfamethoxydiazine (Durenat), taken as an example, is much better when administered simultaneously with a test meal than when given in the fasting state. Also a high-lipid meal in comparison with a high-protein or high-carbohydrate meal considerably improves the bioavailability of sulfamethoxydiazone. Food as well as the composition of food are likely to have short-term and long-term consequences on absorption and biotransformation and therefore influence the bioavailability of drugs.
mesh_terms: D000328:Adult; D001682:Biological Availability; D004040:Dietary Carbohydrates / Q000494:pharmacology; D004041:Dietary Fats / Q000494:pharmacology; D004044:Dietary Proteins / Q000494:pharmacology; D005502:Food; D006801:Humans; D007700:Kinetics; D008297:Male; D013417:Sulfameter / Q000378:metabolism*; D013424:Sulfanilamides / Q000378:metabolism*
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D013424:Sulfanilamides; D013417:Sulfameter
vernacular_title: De Einfluss der Nahrung auf die Bioverfügbarkeit von Medikamenten am Beispiel des Sulfamethoxydiazin.