The effect of protease inhibitors on the immune response in mice.
The effect of protease inhibitors on the immune response in mice was investigated. Soybean inhibitor, aprotinin, alpha 1-antitrypsin and ovomucoid (1 mg) diminished significantly the direct plaque forming cell response per spleen 3 days after immunization with 10(8) sheep erythrocytes (SRBC), when given at the same time as the antigen. With alpha 1-antitrypsin, the effect was not significant 4 days after immunization. With soybean inhibitor, no significant suppressive effect was seen, when the inhibitor was given either 24 hours before or after the antigen. Both aprotinin and ovomucoid diminished a secondary response to SRBC, limited to the indirect plaque forming cells. Soybean inhibitor had an equivocal effect on the secondary response. A suppressive effect of soybean inhibitor, but not ovomucoid was seen using KLH-FITC or LPS-FITC as antigens. Neither soybean inhibitor nor aprotinin had an effect on the induction of delayed-type skin reactivity to oxazolone or FITC.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D004912:Erythrocytes / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000517:prevention & control; D007109:Immunity / Q000187:drug effects*; D008297:Male; D051379:Mice; D010081:Oxazolone / Q000494:pharmacology; D011480:Protease Inhibitors / Q000494:pharmacology*; D012756:Sheep / Q000276:immunology
D011480:Protease Inhibitors; D010081:Oxazolone