title: Prostaglandin synthesis by murine mammary gland is modified by the state of the estrus cycle.
abstract: Mammary glands were excised from female C3H mice at various stages of their estrus cycle. Homogenates incubated at 37 degrees C +/- 10(5) M indomethacin synthesized prostaglandins (PG) E and f2 alpha at rates that varied as a function of the stage at estrus. The rate of PGF2 alpha synthesis was maximal at 1330 pg per mg protein per 2 hr in early diestrus and fell to undetectable levels in early estrus. PGE synthesis exhibited a similar pattern, being maximal at 83 pg per mg protein per 2 hr in early diestrus. These observations suggest that prostaglandins play a role in the cyclic changes observed within the mammary gland.
mesh_terms: D000818:Animals; D004971:Estrus; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D011247:Pregnancy; D011458:Prostaglandins E / Q000096:biosynthesis*; D011460:Prostaglandins F / Q000096:biosynthesis*
chemical_list: D011458:Prostaglandins E; D011460:Prostaglandins F; D007213:Indomethacin