[35S-thiamine transport in the rat small intestine in hypovitaminosis B1 and acute alcoholic intoxication].
35S-thiamine absorption was studied on an isolated strip of the small intestine in experiments on male albino rats with hypovitaminosis B1 and acute alcohol poisoning. The degree of hypovitaminosis was determined by the analysis of blood transketolase. Hypovitaminosis B1 provoked increased thiamine absorption by the mucous membrane of the small intestine. Concurrently, no changes in active transport of thiamine through the wall of the small intestine were observed. Single administration of ethanol in a dose of 5 g/kg body weight into the stomach resulted in a substantial inhibition of active transport, but thiamine accumulation by the mucous membrane remained unchanged. Therefore, ethanol affecting active transport had a less effect on passive diffusion of thiamine. This process, however, depends on thiamine depot saturation in the mucous membrane tissue.
D000435:Alcoholic Intoxication / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D006801:Humans; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D051381:Rats; D013462:Sulfur Radioisotopes; D013831:Thiamine / Q000008:administration & dosage / Q000378:metabolism*; D013832:Thiamine Deficiency / Q000378:metabolism*
D013462:Sulfur Radioisotopes; D013831:Thiamine
Transport 35S-tiamina v tonkoĭ kishke krys pri gipovitaminoze B1 i ostroĭ alkogol'noĭ intoksikatsii.