title: [Circadian rhythm of mortality, spontaneous locomotor activity, and LD50 following application of 1,1,2,2,-tetrabromoethane alone and in combination with ethanol].
abstract: The LD50, the spontaneous locomotor activity, and the circadian rhythm of mortality were determined in male ICR-mice following intraperitoneal injection of 1,1,2,2-tetrabromoethane. By solving the substance in ethanol its toxicity increased significantly, in case of the LD50 by the factor 3.4 and threefold concerning the general mortality. The regression lines calculated for the spontaneous locomotor activity differed significantly with regard to the distance. Significant circadian rhythms of mortality were demonstrated after injections of 1,1,2,2-tetrabromoethane, of tetrabromoethane in ethanol, and of ethanol.
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage* / Q000009:adverse effects; D006842:Hydrocarbons, Brominated / Q000633:toxicity*; D007928:Lethal Dose 50; D051379:Mice; D008813:Mice, Inbred ICR; D009026:Mortality; D009043:Motor Activity / Q000187:drug effects*
chemical_list: D006842:Hydrocarbons, Brominated; D000431:Ethanol; C037530:1,1,2,2-tetrabromoethane
vernacular_title: Zirkadiane Mortalitätsrhythmik, spontane lokomotorische Aktivität und LD50 nach Applikation von 1,1,2,2-Tetrabromäthan allein und in Kombination mit Athanol.