An electroencephalographic study of 4-aminopyridine.
The electroencephalographic (EEG) effects of 4-aminopyridine (4-AP) given intravenously in therapeutic doses were studied in four conscious human volunteers. 4-AP (0.2 mg/kg) caused an increase of the occipital alpha peak frequency of 0.4 to 1.0 Hz. In the dose range of 0.2 to 0.3 mg/kg there was neither evidence for epileptic activity in the EEG nor were any clinical side effects observed. This dose of 4-AP was also found to antagonize diazepam-induced sleep in four volunteers. In addition 4-AP (0.3 mg/kg) hastened the recovery by a factor of 4 in four patients having endoscopic procedures under diazepam-nitrous oxide anesthesia.
D015761:4-Aminopyridine; D000328:Adult; D000631:Aminopyridines / Q000494:pharmacology*; D002319:Cardiovascular System / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology; D004569:Electroencephalography; D006801:Humans; D008297:Male; D009467:Neuromuscular Depolarizing Agents / Q000494:pharmacology*
D000631:Aminopyridines; D009467:Neuromuscular Depolarizing Agents; D015761:4-Aminopyridine; D003975:Diazepam