Effect of fasting on the acute toxicity of HI-6 and its efficacy in soman poisoned mice.
In rodents HI-6 is a very effective antidote of soman poisoning. After fasting, the IP LD50 value of HI-6 decreased from 660 mg/kg to 550 mg/kg. Fasting had no significant effect on the IV LD50 of HI-6. In fasted animals the ED50 for HI-6 (plus atropine) in soman toxicity decreased from 47.5 mg/kg to 14.8 mg/kg. Investigators should be aware of the nutritional status of the animals when comparing data between various laboratories.
D000818:Animals; D000931:Antidotes; D005215:Fasting; D008297:Male; D051379:Mice; D062025:Organophosphate Poisoning; D010091:Oximes; D011726:Pyridinium Compounds / Q000008:administration & dosage / Q000633:toxicity*; D012999:Soman / Q000506:poisoning*
D000931:Antidotes; D010091:Oximes; D011726:Pyridinium Compounds; D012999:Soman; C022870:asoxime chloride