Synthesis of benzofurancarboxylic acids and their aminoesters, potential circulatory drugs.
Aminoesters of the following acids were obtained: 4,6-diacetyl-5-hydroxy- and -5-methoxy-2-methylbenzofuran-3-carboxylic, 5,7-diacetyl-6-hydroxy- and -6-methoxy 3 methylbenzofuran-2-carboxylic, 6-hydroxy-7-p-methoxy-3-methylcinnamoyl-coumarilic and 4,7-dimethoxy-6-hydroxybenzofuran-5-carboxylic. The hydrochlorides of these aminoesters displayed hypotensive and antiarrhythmic activity in doses of 5-10 mg/kg.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis*; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D001572:Benzofurans / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry
D000889:Anti-Arrhythmia Agents; D000959:Antihypertensive Agents; D001572:Benzofurans