title: [Adaptogenic effect of mebikar in emotional stress, physical exertion and hypoxia].
abstract: Adaptogenic effect of mebikar was revealed in experiments on cats, mice and rats. The drug was shown to decrease the emotional stress and to completely remove the stupor-like state in cats induced by stress situation and pain stimulation. The drug slightly increased the lifespan of animals under hypoxic hypoxia and raised the limits of maximum tolerable physical load. It lowered the accumulation of hypoxic lactate. Electron microscopy and biochemical analysis revealed the mebikar-induced increase in glycogen content in muscle cells of the myocardium and in skeletal muscles. The data obtained indicate that mebikar is conducive to optimization of the behavior and some processes of energy metabolism in animals exposed to emotional stress, exercise and hypoxic hypoxia.
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects*; D000223:Adaptation, Psychological / Q000187:drug effects; D000818:Animals; D001736:Biureas / Q000494:pharmacology*; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D002415:Cats; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy; D008297:Male; D051379:Mice; D005082:Physical Exertion / Q000187:drug effects; D051381:Rats; D013315:Stress, Psychological / Q000188:drug therapy; D014149:Tranquilizing Agents / Q000494:pharmacology*
chemical_list: D001736:Biureas; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D014149:Tranquilizing Agents; C015979:mebikar
vernacular_title: Adaptogennyĭ éffekt mebikara pri émotsional'nom napriazhenii, fizicheskoĭ nagruzke i gipoksii.