title: [Synthesis of germinal 3,3-dithienyl compounds (author's transl)].
abstract: A new synthetic approach to the cerebroactive compound (+)-(R)-alpha-[(S)-1-[(3,3-di-3-thienylallyl)amino]ethyl]benzyl alcohol(1) (tinofedrine), its stereoisomers and related derivatives is reported. Several compounds increased blood flow in the arteriae vertebralis and femoralis of anesthesized dog.
mesh_terms: D000818:Animals; D002317:Cardiovascular Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D012039:Regional Blood Flow / Q000187:drug effects; D013237:Stereoisomerism; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D002317:Cardiovascular Agents; D013876:Thiophenes; C018159:tinofedrine
vernacular_title: Synthese geminaler 3,3-dithienylverbindungen.