title: Effect of chronic ipsilateral or contralateral intrauterine infusion of prostaglandin E2 (PGE2) on luteal function of unilaterally ovariectomized ewes.
abstract: The relationship between the chronic intrauterine injection of PGE2 every four hours adjacent or opposite to the corpus luteum on luteal function was studied. Intrauterine infusions every four hours of PGE2 (500 mug) from days 10 to 17 postestrus maintained luteal function only when infused into a uterine horn adjacent to a luteal-bearing ovary of unilaterally ovariectomized sheep with surgically separated uterine cornua. These data are compatible with the hypothesis that PGE2 is a good candidate for the antiluteolysin since it works only through a similar local pathway as the embryo during early pregnancy to sustain the corpus luteum.
mesh_terms: D000818:Animals; D002369:Castration; D004971:Estrus; D005260:Female; D003341:Luteolysis / Q000187:drug effects*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011458:Prostaglandins E / Q000008:administration & dosage*; D012756:Sheep; D014599:Uterus
chemical_list: D011458:Prostaglandins E; D011374:Progesterone