Development of gut hormone responses to feeding in neonates.
The development of the effects of a human milk feed on plasma concentrations of motilin, neurotensin, gastric inhibitory polypeptide, enteroglucagon, gastrin, and secretin were studied in 158 healthy preterm neonates (mean gestation 33 1/2 weeks) at mean postnatal ages of 2 1/2, 6, 13, or 24 days. Pronounced progressive changes occurred in postprandial hormone responses; these were absent or small in the first days of life and were large by age 24 days. These changes may have important consequences in the adaptation to postnatal life.
D000367:Age Factors; D005749:Gastric Inhibitory Polypeptide / Q000097:blood; D005755:Gastrins / Q000097:blood; D005768:Gastrointestinal Hormones / Q000097:blood*; D004763:Glucagon-Like Peptides / Q000097:blood; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007234:Infant, Premature; D008895:Milk, Human; D009037:Motilin / Q000097:blood; D009496:Neurotensin / Q000097:blood; D012633:Secretin / Q000097:blood
D005755:Gastrins; D005768:Gastrointestinal Hormones; D012633:Secretin; D009496:Neurotensin; D009037:Motilin; D005749:Gastric Inhibitory Polypeptide; D004763:Glucagon-Like Peptides