Long term treatment of two familial hypercholesterolemic heterozygote patients with batch affinity chromatography (BAC).
Two familial hypercholesterolemic heterozygote patients were treated for a period of 2 years using an extracorporeal technique involving batch affinity chromatography. In both cases LDL-cholesterol levels were drastically lowered and HDL-cholesterol levels were normalized. No untoward side effects were noted during the 2 year experimental period. These results confirm the safety and simplicity of this technique to lower considerably LDL-cholesterol levels in whole blood of familial hypercholesterolemic patients who do not adequately respond to conventional medical treatment.
D000328:Adult; D000787:Angina Pectoris / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D002846:Chromatography, Affinity / Q000379:methods*; D005260:Female; D006579:Heterozygote; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000235:genetics / Q000628:therapy*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D002784:Cholesterol