title: Structural requirement of sterol nucleus for the silkworm growth and development.
abstract: Several cholesterol analogs structurally modified in nuclear substitutions were tested for sustaining the growth of the silkworm Bombyx mori. 5 alpha-Cholest-7-en-3 beta-o1, 5,7-cholestadien-3 beta-o1 and cholesteryl acetate can replace cholesterol as sterol source for B. mori. Considerably good growth was also obtained with 5 alpha-cholest-14-en-3 beta-o1 and 5 alpha-cholesta-6,8(14)-dien-3 beta-o1. Other sterols tested were either partially effective or ineffective as nutrients.
mesh_terms: D000818:Animals; D012831:Bombyx / Q000187:drug effects / Q000254:growth & development*; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008401:Gas Chromatography-Mass Spectrometry; D013329:Structure-Activity Relationship
chemical_list: D002784:Cholesterol