title: Morphometric analysis of the autophagic and crinophagic lysosomal systems in mammotropes throughout the estrous cycle of the rat.
abstract: The crinophagic and autophagic lysosomal systems were studied in mammotropes (prolactin secreting cells) of the adenohypophysis throughout the estrous cycle of the rat. By means of morphometric analysis, it was found that the volume of secondary autophagic lysosomes was usually greater than that of the crinophagic type. Although the volumes of both secondary autophagic and crinophagic lysosomes were minimal throughout proestrus and diestrus 2, the autophagic lysosomal volume per mammotrope was elevated during the estrous period. The volume of secondary crinophagic lysosomes per mammotrope increased during late estrus and remained elevated throughout early diestrus 1. Furthermore, there was an inverse relationship between the volume of mature secretory granules per cell and of the crinophagic system. These data suggest a role for lysosomes in the regulation of synthesis and secretion of prolactin by the adenohypophysis of the rat.
mesh_terms: D000818:Animals; D001343:Autophagy; D004031:Diestrus; D004971:Estrus; D005260:Female; D008247:Lysosomes / Q000648:ultrastructure*; D008854:Microscopy, Electron; D010903:Pituitary Gland, Anterior / Q000378:metabolism / Q000648:ultrastructure*; D011247:Pregnancy; D011359:Proestrus; D011388:Prolactin / Q000378:metabolism*; D051381:Rats
chemical_list: D011388:Prolactin