Schistosoma mansoni: the survival and reproductive status of mature infections in mice treated with oxamniquine.
A single oral dose of 50 mg/kg of oxamniquine administered to mice with mature infections of Schistosoma mansoni gave rise to a hepatic shift and almost total elimination of the male worms. Regression of the reproductive system and a conspicuous reduction in size took place in the residual females which eventually resembled sexually immature adults. A second dose of oxamniquine had no apparent effect on these females within a period of 28 days following this treatment and it is suggested that this change in reproductive status is the result of discontinued male stimulation.
D000818:Animals; D005260:Female; D008099:Liver / Q000469:parasitology; D008297:Male; D051379:Mice; D009600:Nitroquinolines / Q000494:pharmacology*; D010073:Oxamniquine / Q000494:pharmacology*; D012098:Reproduction / Q000187:drug effects; D012550:Schistosoma mansoni / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D012552:Schistosomiasis / Q000188:drug therapy / Q000469:parasitology*
D009600:Nitroquinolines; D010073:Oxamniquine