Effect of tranexamic acid on the growth and metastasis of V2 carcinoma in rabbits.
The antifibrinolytic action of tranexamic acid (AMCHA) on the growth and metastasis of rabbit V2 carcinoma having high fibrinolytic activity was studied. Upon oral administration of AMCHA, the growth of the tumor and metastasis to the lung tended to be inhibited, and the number of metastatic foci in the regional lymph nodes significantly decreased in the early period of tumor growth. Enhancement of fibrin deposition in the tumor and inhibition of fibrinolytic activity of the tumor were recognized in the AMCHA-treated group. The inhibitory effect of tranexamic acid on fibrin dissolution might interfere with local tumor growth and the release of tumor cells into the vessels.
D000818:Animals; D002277:Carcinoma / Q000188:drug therapy / Q000378:metabolism; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D005337:Fibrin / Q000378:metabolism; D005342:Fibrinolysis; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism; D010960:Plasminogen Activators / Q000032:analysis; D011817:Rabbits; D014148:Tranexamic Acid / Q000494:pharmacology*
D003509:Cyclohexanecarboxylic Acids; D014148:Tranexamic Acid; D005337:Fibrin; D010960:Plasminogen Activators