title: Investigation about the penetration depth in the normal bladder wall and tumor by local instillation of mitomycin into the urinary bladder.
abstract: The penetration depth of mitomycin into the normal urinary bladder wall and tumor was determined in 21 bladder tumor patients. Either 20 mg mitomycin/20 ml distilled water or 40 mg/40 ml distilled water was locally instilled into the bladder with a catheter after emptying it and was left for about 25-l20 min. The individual concentrations of mitomycin within the various bladder layers (epithelial, lamina propria, up to the middle of the musculature) were determined with a thin-layer cup method specially modified for these investigations. The results show a high scatter of resorption from 2 up to 442 micrograms of mitomycin/g dry weight. With this method, mitomycin could be determined in the bladder musculature.
mesh_terms: D000287:Administration, Topical; D006801:Humans; D066298:In Vitro Techniques; D008937:Mitomycins / Q000008:administration & dosage / Q000378:metabolism*; D001743:Urinary Bladder / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D008937:Mitomycins