Transfer of lesions of allergic encephalomyelitis in sheep with cell-free lymph from animals sensitized with homologous spinal cord plus adjuvant.
An experiment was designed to test the hypothesis that the inability to transfer experimental allergic encephalomyelitis (EAE) with serum from sensitized animals was due to the absorption, from the serum, of the relevant antibodies by the target organ of the donor. The immune response to central nervous system (CNS) antigens was isolated to a single lymph node, and the cell-free lymph coming from the node was shown to transfer lesions of EAE to naive recipients. These results are compatible with the hypothesis; however, the antibody nature of the transfer activity has yet to be established.
D000042:Absorption; D000818:Animals; D000906:Antibodies / Q000276:immunology; D002474:Cell-Free System; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D005260:Female; D005620:Freund's Adjuvant / Q000008:administration & dosage; D007116:Immunization, Passive; D007249:Inflammation / Q000473:pathology; D008196:Lymph / Q000637:transplantation*; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D012756:Sheep; D013116:Spinal Cord / Q000276:immunology* / Q000473:pathology
D000906:Antibodies; D005620:Freund's Adjuvant