Chenodeoxycholic acid synthesis in the hamster: a metabolic pathway via 3 beta, 7 alpha-dihydroxy-5-cholen-24-oic acid.
The quantitative significance of the metabolism of 3 beta, 7 alpha-dihydroxy-5-cholen-24-oic acid to chenodeoxycholic acid was evaluated in the hamster. A precursor-product relationship was established in this species by the finding that intravenous administration to an animal previously given cholesterol-4-14C caused a significant reduction in the specific activity of chenodeoxycholic acid. Administration of 12.9 mumole of the precursor was followed by a 10-fold increase in chenodeoxycholic acid excretion although the predominant excretory pathway was via biliary excretion as a monosulfate. The data indicate that synthesis of bile acid from cholesterol via the intermediate 3 beta, 7 alpha-dihydroxy-5-cholen-24-oic acid can be a quantitatively important pathway.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism; D001658:Biliary Fistula; D002250:Carbon Radioisotopes; D002635:Chenodeoxycholic Acid / Q000031:analogs & derivatives* / Q000096:biosynthesis* / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D002849:Chromatography, Gas; D006224:Cricetinae
D001647:Bile Acids and Salts; D002250:Carbon Radioisotopes; D002635:Chenodeoxycholic Acid; C002287:3,7-dihydroxychol-5-enoic acid; D002784:Cholesterol