Flurazepam effects on rat cerebellar Purkinje cells.
1. Cerebellar Purkinje cell activity was recorded in urethane anaesthetized rats. 2. Flurazepam, infused intravenously in divided doses totalling 4 mg/kg, decreased simple spike activity, increased complex spike activity and prolonged local surface inhibition. 3. Iontophoretically applied flurazepam enhanced the effect of GABA and elicited a bursting pattern of discharge when released using larger currents for ejection.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D005479:Flurazepam / Q000494:pharmacology*; D007478:Iontophoresis; D011689:Purkinje Cells / Q000187:drug effects*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D005680:gamma-Aminobutyric Acid; D005479:Flurazepam