[3H]-Salbutamol placental transfer in pregnant rats on the 19th day of gestation.
[3H]-salbutamol added in tracer doses (approximately equal to 250 nmol per animal) to the carrier solution (20 mg/kg) was injected intraperitoneally to pregnant rats on the 19th day of gestation. Some experiments were performed with intravenous administration (approximately equal to 2.5 microCi in 300 microliters 9 g/l NaCl). Drug distribution was studied in the maternal and fetal plasma, lung and liver, and in the placenta and amniotic fluid. 10% of the maternal salbutamol plasma radioactivity was recovered in the fetal plasma, in accordance with earlier findings reported from our laboratory using human placental lobules in vitro.
D000420:Albuterol / Q000378:metabolism*; D000653:Amniotic Fluid / Q000378:metabolism; D000818:Animals; D005260:Female; D005333:Fetus / Q000378:metabolism; D005865:Gestational Age; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D000420:Albuterol