Gastrin releasing peptide reduces meal size in rats.
The satiety-eliciting effect of gastrin-releasing peptide (GRP), a putative mammalian counterpart of bombesin (BBS), was examined in mildly food-deprived rats. Intraperitoneal injections of GRP resulted in a significant decrease of 30-minute food intake at 2, 4, 8 and 16 micrograms/kg, while 1 microgram/kg had no reliable effect. Intraperitoneal GRP at 4 and 8 micrograms/kg did not suppress 30-minute water consumption by thirsty rats. When the dose-effect curves of GRP and BBS are compared on a molar scale, GRP is approximately 30% less potent than BBS in suppressing food intake. The two dose-effect curves are similar in shape and their regression lines have parallel slopes. These data lend further support to the hypothesis that GRP is a mammalian counterpart of BBS and strengthen the argument that they may function as endogenous satiety factors.
D000818:Animals; D001067:Appetite Depressants; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D005508:Food Deprivation; D019886:Gastrin-Releasing Peptide; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D051381:Rats
D001067:Appetite Depressants; D010455:Peptides; D019886:Gastrin-Releasing Peptide