Cytotoxic effects of protease inhibitors on human cells. 2. Effect of elastatinal.
Effects of elastatinal, a protease inhibitor, on DNA repair and its cytotoxicity were investigated in normal human, xeroderma pigmentosum and Chinese hamster V79 cells. There were no effects of elastatinal on DNA repair and UV-induced sister chromatid exchanges, and all 3 cell lines demonstrated essentially the same sensitivity to the cytotoxic effect of elastatinal. These results were quite different from those by antipain, another protease inhibitor, and caffeine.
D000818:Animals; D000976:Antipain / Q000494:pharmacology; D002110:Caffeine / Q000494:pharmacology; D006224:Cricetinae; D003412:Cricetulus; D004260:DNA Repair / Q000187:drug effects*; D005347:Fibroblasts; D006801:Humans; D009154:Mutation; D009842:Oligopeptides / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects / Q000528:radiation effects; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000378:metabolism
D009842:Oligopeptides; D011480:Protease Inhibitors; D000976:Antipain; D002110:Caffeine; C010718:elastatinal