[Pharmacological studies with an ointment containing menthol, camphene and essential oils for broncholytic and secretolytic effects].
Experimental studies in animals were made with an ointment on the basis of menthol, camphene and essential oils (Pinimenthol) to prove its broncholytical and secretolytical effects. According to its recommended clinical application it was tested on the respiratory system as well as by its application on epilated skin. The acetylcholine induced bronchospasms were reduced by 50% when the ointment was insufflated through the respiratory tract. Whereas on epicutaneous application of the drug gave only a slight reduction of the bronchospasms. Significant secretolytical effects of the ointment could be proved by an increase of 44% of the tracheobroncholytical secretion after intratracheal insufflation. An increase of 54% of the secretion was measured after applying the ointment directly to the epilated skin of the animals. Regarding these results an adequate therapeutic effect of the ointment can be expected in humans in chronically obstructive bronchitis and diseases of the respiratory system.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D000081008:Bicyclic Monoterpenes; D001980:Bronchi / Q000187:drug effects / Q000378:metabolism*; D001993:Bronchodilator Agents; D004338:Drug Combinations; D006168:Guinea Pigs; D008610:Menthol / Q000494:pharmacology; D009822:Oils, Volatile / Q000494:pharmacology; D009824:Ointments; D013729:Terpenes / Q000494:pharmacology
D000081008:Bicyclic Monoterpenes; D001993:Bronchodilator Agents; D004338:Drug Combinations; D009822:Oils, Volatile; D009824:Ointments; C028990:Pinimenthol; D013729:Terpenes; D008610:Menthol; C019286:camphene; D000109:Acetylcholine
Pharmakologische Untersuchungen zur broncholytischen und sekretolytisch-expektorierenden Wirksamkeit einer Salbe auf Basis von Menthol, Campher und ätherischen Olen.