Progressive supranuclear palsy, computed tomography, and response to antiparkinsonian drugs.
Three patients with progressive supranuclear palsy demonstrated atrophy of the midbrain, pons, cerebellum, and cerebral hemispheres by computed tomography with horizontal, sagittal, and coronal reconstruction. Benztropine therapy resulted in improvement of speech and gait without significantly affecting the vertical gaze palsy.
D000368:Aged; D001284:Atrophy; D001480:Basal Ganglia Diseases / Q000000981:diagnostic imaging* / Q000188:drug therapy; D001590:Benztropine / Q000627:therapeutic use*; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000473:pathology; D005133:Eye Movements; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008636:Mesencephalon / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000188:drug therapy; D013060:Speech; D014057:Tomography, X-Ray Computed; D014326:Tropanes / Q000627:therapeutic use*
D014326:Tropanes; D001590:Benztropine; D007980:Levodopa