title: [Liberation of ciclopiroxolamine from dermatological preparations (author's transl)].
abstract: Using 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone, 2-aminoethanol salt (ciclopiroxolamine, Cic, Hoe 296, Batrafen) cream as an example, the method for measuring the in vitro liberation from some spreadable dermatological preparations of active substance with an antimycotic action is discussed. In addition, a description is given of a test model for measuring the spreading power of cream or ointment preparations. The tests also include for comparison purposes several antimycotic preparations at present on the market. The extent to which in vitro results of liberation of active substance combined with the results obtained on spreading power permit a prediction as to the penetration and permeation behaviour of an antimycotic preparation applied dermally is discussed.
mesh_terms: D000287:Administration, Topical; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000032:analysis; D000077768:Ciclopirox; D011728:Pyridones / Q000008:administration & dosage* / Q000032:analysis; D012995:Solubility; D013997:Time Factors
chemical_list: D000935:Antifungal Agents; D011728:Pyridones; D000077768:Ciclopirox
vernacular_title: Freigabe von Ciclopiroxolamin aus Dermatika.