Effect of CoQ homologues on the fluidity of phospholipid bilayers a studied by fluorescence polarization of perylene.
The effect of Coenzyme Q analogues on the fluidity of egg lecithin bilayers was studied by fluorescence polarization of perylene. The parameter was clearly affected by the side-chain length of the quinones, by their concentration, and by their redox state. With increasing concentration, short-chain quinones decreased the bilayer fluidity, and did so to an even greater extent in their reduced state. On the contrary, long-chain analogues fluidized the bilayer, the effect being independent of their redox state. Such observations might explain the lower efficiency of short-chain quinones, as compared to the long-chain analogues, in restoring, in vitro, the respiratory activity of CoQ2-depleted mitochondria.
D001551:Benz(a)Anthracenes; D055598:Chemical Phenomena; D002621:Chemistry; D004530:Egg Yolk; D005260:Female; D005454:Fluorescence Polarization; D008051:Lipid Bilayers; D008081:Liposomes; D010084:Oxidation-Reduction; D010569:Perylene; D010713:Phosphatidylcholines; D013050:Spectrometry, Fluorescence; D013499:Surface Properties; D014451:Ubiquinone
D001551:Benz(a)Anthracenes; D008051:Lipid Bilayers; D008081:Liposomes; D010713:Phosphatidylcholines; D014451:Ubiquinone; D010569:Perylene