title: Effect of carbohydrates on the antibacterial activity of patulin on Streptococcus bovis.
abstract: The antibiotic activity of patulin on Streptococcus bovis varied in the presence of different sugars in the incubation medium. The 50% inhibitory concentration (IC50) of patulin was 4.5 times greater in the medium containing glucose than in the lactose-containing medium (100.5 versus 22 micrograms/mL). The addition of two sugars (glucose plus lactose) to the medium was followed by the utilization of glucose only when patulin was present; lack of growth on lactose was not due to beta-galactosidase inactivation by patulin.
mesh_terms: D002241:Carbohydrates / Q000494:pharmacology*; D003470:Culture Media; D004352:Drug Resistance, Microbial / Q000187:drug effects; D005947:Glucose / Q000494:pharmacology; D007785:Lactose / Q000494:pharmacology; D010365:Patulin / Q000494:pharmacology*; D011714:Pyrans / Q000494:pharmacology*; D013291:Streptococcus / Q000187:drug effects* / Q000254:growth & development
chemical_list: D002241:Carbohydrates; D003470:Culture Media; D011714:Pyrans; D010365:Patulin; D005947:Glucose; D007785:Lactose