title: Effects of naftidrofuryl on breathlessness and exercise tolerance in chronic bronchitis.
abstract: Naftidrofuryl enhances oxidative phosphorylation and might therefore be expected to improve exercise tolerance and breathlessness in advanced chronic bronchitis. This hypothesis was tested in a four-week placebo-controlled trial in 11 bronchitic patients. Seven patients completed the study. There was no evidence of any benefit from naftidrofuryl either subjectively or after a 12-minute walking test.
mesh_terms: D000368:Aged; D001991:Bronchitis / Q000188:drug therapy* / Q000503:physiopathology; D002908:Chronic Disease; D005260:Female; D005663:Furans / Q000627:therapeutic use*; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009257:Nafronyl / Q000627:therapeutic use*; D005082:Physical Exertion; D012119:Respiration
chemical_list: D005663:Furans; D009257:Nafronyl