Effect of some sugars and polyols on the kinetics of sorbitol dehydrogenase.
The activity of sorbitol dehydrogenase purified from sheep liver has been measured in the presence of some sugars and polyols. Of these, xylitol exerts an inhibition on SDH activity about four times greater than the others. Since either sorbitol or xylitol significantly influences carbohydrate interconversion, the inhibition type and the inhibition constant for xylitol were determined.
D000438:Alcohols / Q000494:pharmacology*; D000818:Animals; D006601:Hexoses / Q000494:pharmacology*; D007700:Kinetics; D007064:L-Iditol 2-Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D012756:Sheep; D013401:Sugar Alcohol Dehydrogenases / Q000378:metabolism*
D000438:Alcohols; D006601:Hexoses; D013401:Sugar Alcohol Dehydrogenases; D007064:L-Iditol 2-Dehydrogenase