Opiatelike actions of eseroline, an eserine derivative.
Eseroline, an eserine derivative without anticholinesterase activity, was tested in several systems for opiatelike activity. Eseroline depressed the twitch of the field-stimulated guinea pig ileum myenteric plexus longitudinal muscle preparation but failed to depress the twitch of the rat vas deferens. Intraperitoneal injections of eseroline in rats induced naloxone-antagonizable analgesia and catalepsy. Eseroline failed to influence the release of acetylcholine from the cortex of anesthetized rats. These observations have implications for studies in which eserine is used as a pharmacological tool.
D000109:Acetylcholine / Q000378:metabolism; D000700:Analgesics; D000818:Animals; D002375:Catalepsy / Q000139:chemically induced; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D007211:Indoles / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D009294:Narcotics; D051381:Rats
D000700:Analgesics; D007211:Indoles; D009294:Narcotics; D009270:Naloxone; D000109:Acetylcholine; C022594:eseroline