title: 1-amino-3-phenylindoles with antidepressant activity. Binodaline hydrochloride and related substances.
abstract: From a number of novel N-alkylated derivatives of 1-amino-3-phenyl-indole tested as tetrabenzaine antagonists, binodaline hydrochloride (X) has been selected as a potential antidepressant substance for clinical trials. The structure of the side chain is compared to that of known tricyclic antidepressants.
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051379:Mice; D051381:Rats; D013747:Tetrabenazine / Q000037:antagonists & inhibitors
chemical_list: D000928:Antidepressive Agents; D007211:Indoles; C044680:binedaline; D013747:Tetrabenazine