[Brain cortex phospholipids and pituitary gonadotropin incretion (diagnostic use of an acute BC-PL test in secondary amenorrhea of presumably diencephalic origin)].
Bovine brain cortex phospholipids (BC-PL) have a partially dopaminergic effect on the human CNS. This leads to modifications in gonadotropins (FSH, LH and prolactin) pituitary incretion in normal subjects. The Authors have developed an acute test for phospholipids (300 and 600 mg by fast i.v. injection) to be performed in patients suffering from secondary normoprolactinemic amenorrhea possibly of diencephalic origin (hypothesis: hypothalamus function test). In these subjects no change in FSH and LH incretion was observed, whereas blood prolactin levels appeared remarkably reduced. In a small group of patients affected by hyperprolactinemia brain cortex phospholipids produced a more rapid and more marked reduction in blood prolactin (similar to that caused by bromocriptine) in functional conditions in comparison to the organic ones.
D000568:Amenorrhea / Q000175:diagnosis* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000032:analysis*; D005260:Female; D006062:Gonadotropins / Q000097:blood*; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology; D010743:Phospholipids / Q000032:analysis; D010902:Pituitary Gland / Q000378:metabolism*; D011388:Prolactin / Q000097:blood
D006062:Gonadotropins; D010743:Phospholipids; D011388:Prolactin
Fosfolipidi cerebrali ed increzione gonadotropinica ipofisaria (impiego diagnostico di un test acuto ai BC-PL nelle amenorree secondarie di origine presumibilmente diencefalica).