[Relationship between the spectral properties and antifungal properties of amphoterecin B and candicidine].
The antifungal activities of polyen macrolides Amphotericine B and Candicidine are investigated. The deep spectral changes of the absorption and of the circular dichroism show various states of micellar preparations which are: a) in aqueous medium, aggregats of different spectral characteristics, the antifungal activity of which being modulated by the preparation. b) aggregats of antifungal heptaen with membrane-sterol responsable of the antifongal activity. c) aggregats in hydrophobic solutions which spectroscopic properties are sterol-complex like. Our results suggest an explanation of the spectral changes and can point out some favorable characteristics for an optimal activity of these antifungals against yeasts.
D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002174:Candicidin / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D002942:Circular Dichroism; D003904:Mitosporic Fungi / Q000187:drug effects*; D012248:Rhodotorula / Q000187:drug effects*; D013053:Spectrophotometry; D013057:Spectrum Analysis
D000935:Antifungal Agents; D002174:Candicidin; D000666:Amphotericin B
Etude des relations entre les proprietes spectroscopiques et les proprietes antifongiques de l'amphotericine B et la candicidine.