Estrogen inhibits the dopaminergic supersensitivity induced by neuroleptics.
Administration of estrogen to rats during the period of withdrawal from chronic haloperidol attenuated the characteristic increase in apomorphine-induced stereotypy and the increase in (3H) spiroperidol binding. This apparent ability of estrogen to "down-regulate" brain dopamine receptors could lead to useful pharmacological treatments of tardive dyskinesia and possibly of other hyperdopaminergic states.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D004334:Drug Administration Schedule; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D006220:Haloperidol / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism; D013239:Stereotyped Behavior
D011954:Receptors, Dopamine; D004958:Estradiol; D013134:Spiperone; D006220:Haloperidol; D001058:Apomorphine