[On the diuretic and saluretic activity of p-hydroxytriamterene and methoxytriamterene (author's transl)].
Applying i.v. the phase-I-metabolite of 2,4,7-triamino-6-phenylpteridine (triamterene), p-hydroxytriamterene, to rats, we found a strong natriuresis. This contradicts the investigation of a previous study which stated that p-hydroxytriamterene is essentially inactive. We think, these different results depend on the fact that probably oral application was employed without testing the absorption concerned.
D000818:Animals; D004232:Diuretics; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D051381:Rats; D014223:Triamterene / Q000031:analogs & derivatives* / Q000494:pharmacology
D004232:Diuretics; C029656:4-hydroxytriamterene; C029657:4-methoxytriamterene; D014223:Triamterene
Uber die diuretische und saluretische Aktivität von p-Hydroxytriamteren und Methoxytriamteren.