Tonic immobility in domestic fowl: anticataleptic effects of quipazine.
Quipazine, a putative serotonergic agonist, produced marked decreases in tonic immobility (TI) duration in doses of 5--25 mg/kg. Quipazine-treated animals required more elicitation attempts before displaying TI. Quipazine also blocked the haloperidol enhancement of tonic immobility. In a third experiment, quipazine produced stereotyped responses in chickens which yielded increases in activity on a stabilimeter platform. The results are discussed in terms of catalepsy and serotonerigic and dopaminergic mechanisms.
D000818:Animals; D002375:Catalepsy / Q000503:physiopathology*; D002645:Chickens; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D009043:Motor Activity / Q000187:drug effects; D011804:Quinolines / Q000494:pharmacology*; D011814:Quipazine / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors
D011804:Quinolines; D011814:Quipazine; D006220:Haloperidol