Novel adenosine analogues with broad-spectrum biological activity: structure and mechanism of action.
Aliphatic analogues of adenosine, e.g. 9-(S)-(2,3-dihydroxypropyl)adenine, its homologs and carboxy derivatives, display various biological (antiviral, aspermatogenic, chemosterilant, embryotoxic) activities. The principle in common of these effects seems to be an inhibition of SAH-hydrolase which disturbs transmethylations in rapidly proliferating systems.
D000014:Abnormalities, Drug-Induced; D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D001681:Biological Assay; D002642:Chick Embryo; D005260:Female; D007202:Indicators and Reagents; D008297:Male; D009866:Oogenesis / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; D000241:Adenosine