Epidural anesthesia for cesarean section in diabetic parturients: maternal and neonatal acid-base status and bupivacaine concentration.
Acid-base status and blood levels of bupivacaine were determined in 16 diabetic parturients and their infants after epidural anesthesia for cesarean section. The newborn infants were divided into two groups based on umbilical artery pH at birth. Group A consisted of 10 infants who had a pH of less than 7.2 and group B consisted of six infants with a pH of greater than 7.2. Neonatal acidosis was related to both the severity of maternal diabetes and the presence of maternal hypotension after epidural anesthesia. In addition, the half-life to bupivacaine was prolonged in acidotic infants. The placental transfer of bupivacaine, as judged by umbilical vein/maternal vein ratios, was significantly greater in acidotic infants.
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000328:Adult; D000767:Anesthesia, Epidural; D002045:Bupivacaine / Q000097:blood*; D002585:Cesarean Section; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D010100:Oxygen / Q000097:blood; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000378:metabolism*
D010100:Oxygen; D002045:Bupivacaine