Repetitive doses of activated charcoal in Dapsone poisoning in a child.
A case of Dapsone poisoning, treated by repetitive dosing with activated charcoal, is reported. This 18-month-old child showed remarkably rapid resolution of his symptoms with this mode of therapy, becoming symptom free in 64 h. This rapid improvement is attributed to interruption by activated charcoal of the enterohepatic circulation of Dapsone. This mode of therapy may be indicated for other compounds having an enterohepatic circulation.
D002606:Charcoal / Q000627:therapeutic use*; D003622:Dapsone / Q000378:metabolism / Q000506:poisoning*; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male
D002606:Charcoal; D003622:Dapsone