[Intramural injection of anticancer emulsion by gastroendoscopy].
Attempting to establish a topical chemotherapy for stomach cancer, injectable 5-FU emulsion (O/W type) has been developed. The distribution of 5-FU was analyzed by the procedures of quantification and X-rays. The combination of lipiodol having a contrast ability in the oil phase was studied. During the endoscopic examination before operation, 1.0 ml of 5-FU was injected at a site, a total of 50 ml at 2 to 4 sites in the submucosal tissue of the lesion. From the result of examination of 5-FU distribution in the extracted stomach and lymph node, it was confirmed that the drug was retained at the site of injection. In addition, 0.017-0.056 microgram/g on the average of 5-FU concentration was transferred to the secondary lymph node. At the same time, its distribution was monitored by X-rays. In those cases which received intermittent administration for twice or more before operation, the 5-FU concentration was detected at a higher rate than in cases receiving a single dose. This suggests that the therapy is markedly effective for stomach cancer and its metastasis to the lymph node as topical therapy.
D000818:Animals; D004285:Dogs; D004655:Emulsions; D005472:Fluorouracil / Q000008:administration & dosage*; D005773:Gastroscopy; D007267:Injections; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D009360:Neoplastic Cells, Circulating; D051381:Rats; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
D004655:Emulsions; D005472:Fluorouracil