Effect of purified epoxide hydrolase on metabolic activation and binding of benzo(a)pyrene to exogenous DNA. Shift of the activation pathway.
D000818:Animals; D001580:Benzopyrenes / Q000378:metabolism*; D002850:Chromatography, Gel; D019388:Cytochrome P-450 CYP1A2; D003580:Cytochromes / Q000494:pharmacology; D004247:DNA / Q000378:metabolism*; D004101:Dihydroxydihydrobenzopyrenes; D004851:Epoxide Hydrolases / Q000494:pharmacology*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D008862:Microsomes, Liver / Q000378:metabolism*
D001580:Benzopyrenes; D003580:Cytochromes; D004101:Dihydroxydihydrobenzopyrenes; C017228:benzo(a)pyrene 7,8-dihydrodiol; C021337:9-hydroxybenzo(a)pyrene; D008748:Methylcholanthrene; D004247:DNA; C017170:Cyp1a2 protein, rat; D019388:Cytochrome P-450 CYP1A2; D004851:Epoxide Hydrolases