title: Release and rectal absorption of aminophylline suppositories prepared in a hospital pharmacy.
abstract: In vitro release and in vivo rectal absorption of suppositories containing aminophylline and various bases prepared in our hospital pharmacy were investigated. The release tests were conducted using three methods: the cylindrical filter paper method, the Sartorius solubility simulator method and the disintegration test in J.P. IX. In all cases, release from PEG-containing suppositories was better than that from Witepsol-containing products. However, this tendency was not reflected in the blood level of theophylline after rectal absorption of these suppositories.
mesh_terms: D000042:Absorption; D000628:Aminophylline / Q000008:administration & dosage* / Q000378:metabolism; D000818:Animals; D007700:Kinetics; D008297:Male; D008722:Methods; D010209:Paper; D011092:Polyethylene Glycols; D011817:Rabbits; D012007:Rectum / Q000378:metabolism*; D012995:Solubility; D013488:Suppositories; D013806:Theophylline / Q000097:blood; D014280:Triglycerides
chemical_list: D013488:Suppositories; D014280:Triglycerides; C009683:witepsol; D000628:Aminophylline; D011092:Polyethylene Glycols; D013806:Theophylline