title: The independence of closely spaced discrete experimental spike foci.
abstract: Stable spike foci generated by weak penicillin solutions had a minimal area of distribution of 12.5 mm2. Two foci separated by 4 mm on the same gyrus were consistently dependent and simultaneous. An area of "positive surround" between the two spikes did not prevent dependency. This contradicts the hypothesis that "positive surround" prevents spreading of epileptiform discharges. Spike foci separated by 6 mm were almost always independent. Bursts of afterdischarges remained independent if the primary spikes were independent. Postafterdischarge suppression and spreading depression of Leao affected independent spike focus selectively. These experiments suggest that cross-talking between cortical columns is limited to column 1 to 2 mm apart.
mesh_terms: D000818:Animals; D002415:Cats; D004569:Electroencephalography; D010400:Penicillin G / Q000008:administration & dosage; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*
chemical_list: D010400:Penicillin G