REM sleep deprivation changes behavioral response to catecholaminergic and serotonergic receptor activation in rats.
The effects of REM sleep deprivation (REMD) on apomorphine-induced aggressiveness and quipazine-induced head twitches in rats were determined. Forty-eight hr of REMD increased apomorphine-induced aggressiveness, and reduced (immediately after completing of REMD) or increased (96 hr after completing of REMD) quipazine-induced head twitches. Results are discussed in terms of similarity to pharmacological effects of other antidepressive treatments.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D006801:Humans; D008297:Male; D011814:Quipazine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects*; D012892:Sleep Deprivation / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology*; D013239:Stereotyped Behavior / Q000187:drug effects
D011941:Receptors, Adrenergic; D011985:Receptors, Serotonin; D011814:Quipazine; D001058:Apomorphine