title: Brain-specific ceramide synthesis activity: change during brain maturation and in jimpy mouse brain.
abstract: The synthesis of ceramide from lignoceric acid was studied in normally developing rat brain and jimpy mouse brain. The developmental pattern of the synthesis of both non-hydroxy and hydroxyceramide from free lignoceric acid in a brain-specific pathway requiring NADPH and cytosolic factors was similar to the synthesis from lignoceroyl CoA and both showed increasing activity during myelination. There were no differences in non-hydroxyceramide synthesis between jimpy and normal littermate control mouse brains by both pathways. HPLC analysis showed the same non-hydroxyceramide level in both types of brains.
mesh_terms: D000375:Aging; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002518:Ceramides / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003600:Cytosol / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D051379:Mice; D008816:Mice, Jimpy; D009186:Myelin Sheath / Q000378:metabolism*; D051381:Rats
chemical_list: D002518:Ceramides; D005227:Fatty Acids; C010210:lignoceric acid