title: [Cyclohexylphenoxymorpholines with antidepressive activity].
abstract: A report is given of the synthesis and pharmacological investigation of some cyclohexylphenoxymethylmorpholines of general formula: Formula: (see text). The compound in which R = H and bearing the cyclohexyl group at the ortho position showed a pharmacological profile typical of drugs with antidepressant activity and was studied in detail in comparison with viloxazine and imipramine.
mesh_terms: D000374:Aggression / Q000187:drug effects; D000818:Animals; D000927:Anticonvulsants; D000928:Antidepressive Agents / Q000138:chemical synthesis*; D001522:Behavior, Animal / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007858:Learning / Q000187:drug effects; D051379:Mice; D008996:Monoamine Oxidase Inhibitors; D009025:Morpholines / Q000138:chemical synthesis*; D009119:Muscle Contraction / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors
chemical_list: D000927:Anticonvulsants; D000928:Antidepressive Agents; D008996:Monoamine Oxidase Inhibitors; D009025:Morpholines; D012110:Reserpine
vernacular_title: Cicloesilfenossimorfoline ad attività antidepressiva.