Preliminary in vitro study of diazepam and droperidol on oestrus rat uterus.
The actions of diazepam and droperidol were studied on the spontaneously active and oxytocin-treated oestrus rat uterus. Both drugs significantly depressed the frequency of uterine contraction. Droperidol reduced the amplitude of contractions and the basal tone of the tissue. The sensitivity of the tissue to both drugs was enhanced in the presence of the smallest concentration of oxytocin (0.2 mu. ml-1). Prior exposure of the tissue to droperidol sensitized the muscle to oxytocin.
D000818:Animals; D003864:Depression, Chemical; D003975:Diazepam / Q000494:pharmacology*; D004329:Droperidol / Q000494:pharmacology*; D004971:Estrus; D005260:Female; D066298:In Vitro Techniques; D010121:Oxytocin; D011247:Pregnancy; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects*
D010121:Oxytocin; D004329:Droperidol; D003975:Diazepam