Characterisation of a human Y chromosome repeated sequence and related sequences in higher primates.
The human Y chromosome carries 2000 copies of a tandemly repeated sequence, 2.47 kb long, which constitutes about 20% of the DNA of this chromosome. These sequences are localised on the tip of the long arm of the Y chromosome. Related sequences are present in DNA of females with a related but distinguishable restriction pattern. These autosomal sequences are distributed in tandem arrays on a number of autosomes. Related sequences are also present in gorilla and chimpanzee. In gorilla they resemble the human sequences in their restriction map but are not found on the Y chromosome whereas in chimpanzee the related sequences behave as a 'dispersed' repeat. Changes in the level of methylation of this sequence in different tissues of human males can be detected with the lowest levels found in sperm and placental DNA.
D000818:Animals; D004247:DNA / Q000235:genetics*; D005260:Female; D006071:Gorilla gorilla / Q000235:genetics*; D006801:Humans; D008297:Male; D008745:Methylation; D009693:Nucleic Acid Hybridization; D002679:Pan troglodytes / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D012730:Sex Chromosomes / Q000032:analysis*; D013045:Species Specificity; D014998:Y Chromosome / Q000032:analysis*
D004247:DNA