Does a rhythmicity of serum concentrations and urinary excretion of dipyridamole exist during long-term treatment?
No daily rhythmicity of changes in dipyridamole (Curantyl-Germed) concentration in the blood serum of chronically treated patients receiving orally 75 mg of dipyridamole every 8 hr was found. The urinary excretion of dipyridamole was 1.37 mg/day (0.6% of the daily dose) and was significantly lower between 18.00--2.00 hr in comparison with excretion between 2.00--0.00 and 10.00-18.00.
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002940:Circadian Rhythm; D004176:Dipyridamole / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D006505:Hepatitis / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D004176:Dipyridamole