Transient abolition of generalized photosensitive epileptic discharge in humans by apomorphine, a dopamine-receptor agonist.
Apomorphine, an agonist of dopamine receptors, blocks or significantly reduces photically induced seizures in the baboon (Papio papio). We therefore studied the effect of subcutaneously administered apomorphine in 11 patients with generalized photosensitive epilepsy. Visual evoked potentials were not altered by apomorphine, but in nine patients apomorphine transiently blocked the epileptic photosensitivity for an average of 45 minutes. Therefore, dopaminergic mechanisms play a role in the pathophysiology of human generalized photosensitive epilepsy.
D000293:Adolescent; D000328:Adult; D001058:Apomorphine / Q000494:pharmacology* / Q000627:therapeutic use; D004298:Dopamine / Q000378:metabolism; D004827:Epilepsy / Q000188:drug therapy* / Q000209:etiology; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D010775:Photic Stimulation; D011954:Receptors, Dopamine / Q000187:drug effects*; D013997:Time Factors
D011954:Receptors, Dopamine; D001058:Apomorphine; D004298:Dopamine