Cell membrane anomaly in genetically determined manic-depressive illness.
A group of 25 pairs of monozygotic twins has been investigated for twin concordance in relation to affective illness and lithium erythrocyte/plasma ratios. Lithium ratios are significantly greater in twins concordant for affective illness as compared to discordant twins, suggesting the presence of a membrane anomaly as a possible vulnerability factor in subjects genetically predisposed to affective illness.
D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics* / Q000378:metabolism; D004200:Diseases in Twins; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D008094:Lithium / Q000097:blood; D008875:Middle Aged; D011247:Pregnancy; D014430:Twins, Monozygotic
D008094:Lithium