The minimal length of the differential segment in H-2 congenic lines.
One hundred and four H-2 congenic lines were typed for alleles at seven loci, Qa-1, Qa-2, Tla, C3, Ce-2, Pgk-2, and Upg-1, residing distal to the H-2 complex. The results of the typing were used to estimate the length of the segment of chromosome 17 derived from the donor strain of each line--that is, the minimal length of the differential segment. The results indicate that only lines derived by intra-H-2 crossing-over in such a way that they inherited the right-hand portion of H-2 from the inbred partner have the telomeric half of chromosome 17 identical with that of the inbred-partner strain. In other lines the differential segment is at least 3 to 10 cM long. It is argued that in some lines the entire telomeric half of chromosome 17 might be of donor-strain origin.
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics; D002874:Chromosome Mapping; D004798:Enzymes / Q000235:genetics; D005796:Genes; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D011995:Recombination, Genetic
D000954:Antigens, Surface; D004798:Enzymes; D006183:H-2 Antigens