Antimitotic and cytotoxic activity of cis-dichlorobis-(cyclohexylamine)platinum(II) on Chinese hamster ovary cells.
The antimitotic and cytotoxic effects of cis-dichlorobis(cyclohexylamine)-platinum(II) (cis-HAD) which among Pt complexes used as antitumoral drugs shows the highest therapeutic index (TI) have been compared to those os cis-dichlorodiamine platinum(II) (cis-DDP), the most commonly used drug of this group, using Chinese hamster ovary cell cultures (CHO line). DNA synthesis inhibition, mitotic index, cell viability, chromosome aberrations and cell survival have been taken into account. The data indicates that the antimitotic agent cis-HAD is active only at doses causing high cell mortality and chromosome damage.
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D002869:Chromosome Aberrations; D002945:Cisplatin / Q000633:toxicity; D006224:Cricetinae; D003412:Cricetulus; D003514:Cyclohexylamines / Q000633:toxicity; D004247:DNA / Q000096:biosynthesis; D005260:Female; D008938:Mitosis / Q000187:drug effects*; D009944:Organoplatinum Compounds / Q000633:toxicity*; D010053:Ovary
D000970:Antineoplastic Agents; D003514:Cyclohexylamines; D009944:Organoplatinum Compounds; C022095:dichlorobis(cyclohexylamine)platinum; D004247:DNA; D002945:Cisplatin