Tissue distribution of 2- and 4-[203Hg]-estradiol in mammary-tumor-bearing rats.
The newly synthesized 2-[203Hg]-estradiol-17 beta and 4-[203Hg]-estradiol-17 beta were injected into Fischer female rats bearing transplanted mammary adenocarcinomas and into Sprague-Dawley female rats bearing spontaneous mammary tumors. Four days after injection, tumor to blood ratios (and uterine to blood ratios) in the various groups were between 5 and 14, compared to a ratio of unity observed in normal mammary glands. When injected into male rats, the accumulation of 4-[203Hg]-estradiol in the prostate and in the epididimis was very low. With minute doses of 4-[203Hg]-estradiol injected into healthy male rats, the whole-body retention of the drug was found to decrease exponentially with time, and biphasic first order kinetics were observed. With pharmacological doses of the same drug, the clearance exhibited a biphasic pattern.
D000230:Adenocarcinoma / Q000378:metabolism*; D000818:Animals; D004958:Estradiol / Q000097:blood / Q000378:metabolism*; D005260:Female; D007700:Kinetics; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism*; D008631:Mercury Radioisotopes; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014018:Tissue Distribution
D008631:Mercury Radioisotopes; D004958:Estradiol