[Inhibitory effect of homologous antiviral antibodies on viral cell destruction].
Experiments were performed on the model Chinese hamster cell culture -- Sindbis virus in which there develops an acute infection accompanied by active virus reproduction, cell rounding and detachment from the glass for 24--48 h. Addition in the cultural medium of a 0.5% immune serum to the Sindbis virus after its adsorption by the monolayer culture fully prevents the development of cytopathic changes and favours obtaining chronically infected cultures that produce the infection virus. The decreased production of intracellular and surface viral antigens in the infected cells seems likely to be accounted for by blocking the function of viral genome by homologous antibodies that join virus-induced antigens in the cellular plasmalemma.
D000818:Animals; D000914:Antibodies, Viral; D001102:Arbovirus Infections / Q000517:prevention & control*; D002478:Cells, Cultured; D006224:Cricetinae; D003588:Cytopathogenic Effect, Viral; D012845:Sindbis Virus / Q000276:immunology*
D000914:Antibodies, Viral
Ingibiruiushchee vliianie gomologichnykh protivovirusnykh antitel na virusnoe porazhenie kletok.