Alzheimer disease: lack of effect of lecithin treatment for 3 months.
Eleven outpatients with Alzheimer disease of moderate severity completed a double-blind placebo-controlled crossover trial of lecithin. Each patient received 10 gm three times daily of a placebo for 3 months. Plasma choline levels rose threefold and remained at that level throughout the lecithin administration period. A significant difference between mean baseline scores and treatment scores was found on tests of new learning ability, indicating a practice effect in these tests. However, there were no differences between mean placebo and lecithin scores on any of the psychological test measures.
D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy*; D002794:Choline / Q000097:blood; D003704:Dementia / Q000188:drug therapy*; D004311:Double-Blind Method; D006801:Humans; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D011581:Psychological Tests; D013997:Time Factors
D010713:Phosphatidylcholines; D002794:Choline