Experimental study of skin-sensitizing antibodies after aerosol and subcutaneous immunization.
The reaction of passive skin anaphylaxis was used to investigate the accumulation and the dynamics of skin-sensitizing antibodies (SSA) in the sera of guinea pigs immunized with botulin anatoxin by means of different methods: the aerosol and the subcutaneous method. In the aerosol-immunized animals (unlike the subcutaneously immunized ones) SSA appeared in a negligible amount only after the fourth immunization and disappeared rapidly.
D000336:Aerosols; D000818:Animals; D000917:Antibody Formation; D001904:Botulinum Antitoxin / Q000008:administration & dosage / Q000032:analysis; D006168:Guinea Pigs; D007114:Immunization / Q000379:methods*; D007279:Injections, Subcutaneous; D010323:Passive Cutaneous Anaphylaxis; D011935:Reagins / Q000096:biosynthesis*
D000336:Aerosols; D001904:Botulinum Antitoxin; D011935:Reagins