gamma-Aminobutyric acid concentrations in the cerebrospinal fluid of newborn infants.
gamma-Aminobutyric acid (GABA) concentrations in cerebrospinal fluid (CSF) were measured in 20 neonates with various gestational and postnatal ages. These concentrations varied between 9 and 45 nmol/ml which is approximately 20-100 times the concentrations found in adults. CSF GABA concentrations tended to decrease with advancing gestational age. No apparent alterations were noted with increasing postnatal age (until 6 weeks of age). Asphyxia but not neonatal sepsis was accompanied by an increase in CSF GABA concentrations compared to respective controls.
D001238:Asphyxia Neonatorum / Q000134:cerebrospinal fluid; D001424:Bacterial Infections / Q000134:cerebrospinal fluid; D005865:Gestational Age; D005947:Glucose / Q000134:cerebrospinal fluid; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000134:cerebrospinal fluid; D005680:gamma-Aminobutyric Acid / Q000134:cerebrospinal fluid*
D005680:gamma-Aminobutyric Acid; D005947:Glucose