Investigation of the hydrocarbons found in the tissues of chickens injected with inactivated oil adjuvant vaccine.
Dead virus vaccines emulsified with mineral oils and given by intramuscular or subcutaneous routes are widely used in prophylaxis of several conditions in poultry. In order to establish in what amount and how long mineral oils remain in the vicinity of the injection site, an investigation was made on broilers vaccinated against Newcastle disease with this type of vaccine. At different time intervals between the 10th and 282th day after vaccination, soft tissues were removed from over the bone surface of the tibia of inoculated legs and of control legs, and were subsequently examined. The results showed that the hydrocarbons introduced by vaccination remain in considerable amounts in the tissues examined, even 282 days after vaccination.
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000032:analysis; D000818:Animals; D002645:Chickens; D005260:Female; D006838:Hydrocarbons / Q000032:analysis* / Q000378:metabolism; D008460:Meat / Q000032:analysis*; D008899:Mineral Oil / Q000008:administration & dosage* / Q000032:analysis
D000276:Adjuvants, Immunologic; D006838:Hydrocarbons; D008899:Mineral Oil