[Immunomodulating properties of an extract isolated and partially purified from Aloe vahombe. 3. Study of antitumoral properties and contribution to the chemical nature and active principle].
An immuno-modulator fraction (Alva) extracted from an endemic plant, in the south of Madagascar, the Aloe vahombe, significantly protects mice against bacterial, parasitic and fungal infections. Wishing to verify whether the fraction Alva was active in tumour reduction, we studied its effect on the development of experimental fibrosarcoma and melanoma in mice by intravenous and intracutaneous injections and injections directly into the tumour of the immunostimulant fraction. We have observed cures, only in the case of the McC3-1 tumour but it is encouraging to note that under different experimental conditions the rate of growth of tumours in animals which were treated is slower than in those not treated. The Alva fraction is a substance which is hydrosoluble, thermostabile, having a molecular weight exceeding 30 000 and is a polysaccharide. The predominant sugars are glucose and mannose in 3:1 ratio. Preliminary studies of its action seem to indicate that the Alva fraction acts upon non-specific response and could possibly stimulate the phagocyte activity of the peritoneal macrophagus.
D000504:Aloe / Q000276:immunology*; D000818:Animals; D005354:Fibrosarcoma / Q000188:drug therapy; D008270:Madagascar; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000276:immunology* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000276:immunology*; D012513:Sarcoma, Experimental / Q000188:drug therapy
D010936:Plant Extracts
Etude des propriétés immunodulatrices d'un extrait isolé et partiéllement purifié à partir de l'Aloe vahombe. 3. Etude des propriétés antitumorales et contribution à l'étude de la nature chimique du principe actif.