[Agranulocytosis induced by rifamycin SV in a patient with Hodgkin's disease. Immunologic considerations and pathogenetic interpretations].
Alter a comprehensive introduction, intended to vocalize the pharmacologically-induced leukopenia problem, it is herein described an agranulocytosis case, Rifamicin SV-induced, in an abdominal Hodgkin subject. In the process determinism, much probably immunological, we deem two factors, at least, having acted in convergence: the Rifamicin haptenic activity and the immunosuppressive action of the same. We also believe that, in the pathogenesis of the hematological situation observed, a fundamental role must be ascribed to the immuno-deficient conditions peculiar to patients affected by Hodgkin's disease.
D000380:Agranulocytosis / Q000139:chemically induced* / Q000150:complications / Q000276:immunology; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D008875:Middle Aged; D012294:Rifamycins / Q000009:adverse effects*
D012294:Rifamycins; C023808:rifamycin SV
Agranulocitosi indotta da rifamicina SV in un paziente con malattia di Hodgkin. Considerazioni immunologiche ed interpretazioni patogenetiche.