[Allosteric regulation of glucosamine synthetase activity by naphthoquinone derivatives and ethyl ester of di-(4-oxycumarinyl-3)-acetic acid].
The effects of derivatives of naphthoquinone, e.g. 2-methyl-3-phytyl-1,4-naphthoquinone (vitamin K1), 2-methyl-1,4-naphthoquinone (vitamin K3), 3-dihydro-2-methyl-1,4-naphthoquinone-2-sodium sulfonate (vicasol), derivatives of naphthohydroxyquinone, e.g. 2-methyl-1,4-naphthohydroxyquinone 1-monoacetate, 2-methyl-1,4-naphthohydroxyquinone 1,4-diacetate and the oxycumarine derivative di-(4-oxycumarinyl-3)-acetate ethyl ester (pelentan) on the activity of purified glutamine synthetase (EC 5.3.1.19) from rat liver were studied. The enzyme activity was increased under effects of vitamins K1 and K3 and was inhibited by pelentan. The data obtained are indicative of the allosteric effect of these compounds on the enzyme.
D000818:Animals; D002238:Carbohydrate Epimerases / Q000378:metabolism*; D005017:Ethyl Biscoumacetate / Q000494:pharmacology*; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D009285:Naphthoquinones / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D009285:Naphthoquinones; D005017:Ethyl Biscoumacetate; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); D002238:Carbohydrate Epimerases
Allostericheskaia reguliatsiia aktivnosti gliukozaminsintetazy proizvodnymi naftokhinona i etilovym efirom di-(4-oksikumarinil-3)-i uksusnoĭ kisloty.