Selectivity of an indole-hydrazide derivative as inhibitor of mouse brain type A monoamine oxidase.
The first indole-hydrazide, 1-[2,-(3-methyl)-5-benzyloxyindolyl]carbonyl-2-isopropyl hydrazide (IH-3), that irreversibly inhibits mouse brain type A monoamine oxidase is measured by 5-hydroxytryptamine deamination. The concentration required in vitro to inhibit this isoenzyme is about 7 X 10(-8) mol/l. Other biochemical and pharmacological features of this potential antidepressant are presented.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D003641:Deamination; D007211:Indoles / Q000494:pharmacology*; D007700:Kinetics; D051379:Mice; D008996:Monoamine Oxidase Inhibitors; D009043:Motor Activity / Q000187:drug effects; D010627:Phenethylamines / Q000378:metabolism; D012110:Reserpine / Q000037:antagonists & inhibitors; D012701:Serotonin / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism; D014439:Tyramine / Q000378:metabolism
D007211:Indoles; D008996:Monoamine Oxidase Inhibitors; D010627:Phenethylamines; D012701:Serotonin; C032861:1-(2-(3-methyl-5-benzyloxyindolyl)carbonyl)-2-isopropyl hydrazide; D012110:Reserpine; D014439:Tyramine