On the influence of orciprenaline on uterine motility and on plasma levels of estradiol-17 beta in pregnant and parturient sheep.
Orciprenaline infusions in laboring ewes suppressed uterine activity. A complete inhibition of uterine activity could only be obtained in the empty uterine horn of laboring ewes. During late pregnancy a complete inhibition of the pregnant horn could be established with orciprenaline doses much lower than those necessary duringparturition. In all treated ewes, aberrant patterns of plasma estradiol-17 beta levels were observed: very high maternal estradiol-17 beta levels were detected after treatment with orciprenaline. It is suggested that orciprenaline influences fetal adrenocortical functioning.
D000818:Animals; D004958:Estradiol / Q000097:blood*; D005260:Female; D007743:Labor, Obstetric / Q000187:drug effects*; D009921:Metaproterenol / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D012756:Sheep; D014590:Uterine Contraction / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects
D004958:Estradiol; D009921:Metaproterenol