title: A pharmacological analysis of levonantradol antinociception in mice.
abstract: Using the hot plate test, the potency and mechanism of the analgesic activity of levonantradol was studied in mice. Levonantradol is 10 to 30 times more potent than morphine; the antinociception can be only partially blocked by naloxone. Similar limited antagonism by cholinergics indicates possible opiodergic mechanism. The role of serotoninergic pathways is unclear; antinociception is partially blocked by 5,7-dihydroxytryptamine, unaffected by p-chlorophenylalanine, and potentiated by cyproheptadine. Levonantradol blocks naloxone-induced signs of abstinence in morphine-dependent mice, being 3000 times more potent than morphine and 300 times more potent than delta 9-tetrahydrocannabinol (THC).
mesh_terms: D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000700:Analgesics; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D003533:Cyproheptadine / Q000494:pharmacology; D006801:Humans; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D010617:Phenanthridines / Q000494:pharmacology*; D010643:Phenoxybenzamine / Q000494:pharmacology; D013375:Substance Withdrawal Syndrome / Q000523:psychology; D013997:Time Factors
chemical_list: D000700:Analgesics; D010617:Phenanthridines; D010643:Phenoxybenzamine; D003533:Cyproheptadine; D015116:5,7-Dihydroxytryptamine; D009270:Naloxone; D009020:Morphine; D001285:Atropine; C025490:nantradol