title: Effect of mazindol on feeding behaviour and on noradrenergic function of various parts of the rat brain.
abstract: The effect of mazindol on feeding behaviour was investigated in rats fasted for 24 hours. They were then given mazindol i.p. and placed in a new environment. The effect of the drug on the disappearance of 3H-noradrenaline (3H-NA) from various parts of the brain after injection into the cerebral ventricles was also investigated. Mazindol was more potent in suppressing feeding behaviour than in reducing food intake, indicating that a number of aspects of feeding behaviour may be more sensitive indices of the anorectic effect of a drug than food intake per se. Mazindol, in a dose of 30 mg/kg, accelerated the disappearance of 3H-NA from the medial hypothalamus but not from other areas of the brain, suggesting that the drug has a locus-specific action on cerebral noradrenaline metabolism.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D005247:Feeding Behavior / Q000187:drug effects*; D006624:Hippocampus / Q000378:metabolism; D007033:Hypothalamus, Middle / Q000378:metabolism; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D008454:Mazindol / Q000494:pharmacology*; D008526:Medulla Oblongata / Q000378:metabolism; D008657:Metabolic Clearance Rate / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism*; D011149:Pons / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical
chemical_list: D007211:Indoles; D008454:Mazindol; D009638:Norepinephrine