Evaluation of ketamine/xylazine anesthesia in the guinea pig: toxicological parameters.
The characteristics of ketamine/xylazine combinations were evaluated in guinea pigs. Particular attention was focused on the establishment of an LD50 and the development of a dose-response curve. Basic serum parameters (BUN, serum creatinine, and SGPT) were monitored for 5 days post-anesthesia. A large safety margin was indicated by an LD50 range of 361-373 mg/kg ketamine. The dose-response curve was linear between 40 and 120 mg/kg ketamine with constant 10 mg/kg xylazine. Although serum parameters were elevated 5 days postanesthesia they remained within normal limits for laboratory rodents.
D000410:Alanine Transaminase / Q000097:blood; D000758:Anesthesia / Q000662:veterinary*; D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D006168:Guinea Pigs / Q000097:blood*; D007649:Ketamine / Q000633:toxicity*; D007928:Lethal Dose 50; D013843:Thiazines / Q000633:toxicity*; D013997:Time Factors; D014991:Xylazine / Q000633:toxicity*
D013843:Thiazines; D014991:Xylazine; D007649:Ketamine; D003404:Creatinine; D000410:Alanine Transaminase