Alteration of calcium transport in Duchenne erythrocytes.
Erythrocyte calcium transport as a function of free [Ca++] was examined using inside-out vesicles from eight pairs of patients with Duchenne dystrophy and age- and sex-matched controls. The Km for Ca++ of the transport protein and the Vmax were higher in the Duchenne vesicles in seven of the eight pairs. The mean Km and Vmax were significantly higher in the Duchenne group.
D000255:Adenosine Triphosphate / Q000097:blood; D001692:Biological Transport; D002118:Calcium / Q000097:blood*; D002648:Child; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008274:Magnesium / Q000097:blood; D009136:Muscular Dystrophies / Q000097:blood*
D000255:Adenosine Triphosphate; D008274:Magnesium; D002118:Calcium