The expression of MHC antigens by human teratocarcinoma derived cell lines.
We have used flow microfluorimetry to investigate quantitatively the expression of HLA-A, B and C antigens, and beta 2 microglobulin, by cell lines derived from human teratocarcinomas, Although low levels of these cell surface molecules were expressed by all the lines examined, there was no evidence of discrete HLA-A, B, C/beta 2-microglobulin positive and negative subpopulations in any cultures. In contrast, using similar techniques, no murine embryonal carcinoma cell line was found to express the homologous H-2 antigens, It is suggested that human embryonal carcinoma cells may differ from their mouse counterparts by expressing low levels of major histocompatibility antigens
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000937:Antigen-Antibody Reactions; D000954:Antigens, Surface / Q000276:immunology; D002460:Cell Line; D006183:H-2 Antigens / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D008297:Male; D051379:Mice; D013724:Teratoma / Q000276:immunology*; D013736:Testicular Neoplasms / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D006183:H-2 Antigens; D006680:HLA Antigens