title: Immunological parameters in midline granuloma.
abstract: Midline granuloma and Wegener's granulomatosis are thought to be variants of the same disease. We report studies on a patient with midline granuloma over a 14-month period from the presentation of the disease, in whom a raised serum IgE concentration and a depressed NBT test value were found. These parameters fluctuated with the course of the disease. In addition, a high percentage of IgE positive plasma cells were found in two different sites of the disease. These findings suggest that the aetiology of midline granuloma may be related to hypersensitivity with a concurrent depression in the functional capacity of neutrophils.
mesh_terms: D001799:Blood Sedimentation; D005260:Female; D006103:Granuloma, Lethal Midline / Q000209:etiology / Q000276:immunology*; D014890:Granulomatosis with Polyangiitis / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis; D007136:Immunoglobulins; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis; D010950:Plasma Cells / Q000276:immunology
chemical_list: D007136:Immunoglobulins; D007073:Immunoglobulin E