title: Chronic studies in rats exposed to liquid effluent from coal gasification process.
abstract: The health effects of the E-effluent (water for quenching ash) from a coal gasification plant were assayed in a chronic experiment (16 month exposure) and a three generation reproduction study. Animals exposed to 100% E-effluent had an increased daily intake of various inorganic elements (Fe, Cu, K, I, Se, Cd, Hg, Pb, As, F and Cr). In spite of that, the exposed and control animals had the same mortality rate, haematological findings, urinary protein excretion, trace element concentrations in kidneys, liver and femur, bone composition and morphometry, and histological findings. The pre- and post-natal development and growth was unchanged during three generations. It is concluded that the higher intake of various inorganics caused no change in the parameters measured.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000378:metabolism*; D003031:Coal; D004326:Drinking; D005260:Female; D006403:Hematologic Tests; D008297:Male; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D013997:Time Factors; D014018:Tissue Distribution; D014131:Trace Elements / Q000378:metabolism*; D014873:Water Pollutants / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D003031:Coal; D014131:Trace Elements; D014873:Water Pollutants; D014874:Water Pollutants, Chemical