title: [Photodynamic injuries of erythrocytes during illumination with blue light in patients with icterus neonatorum].
abstract: In a prospective study the influence of intermittent phototherapy (with and without riboflavin substitution) on red blood cells of newborns was examined in vivo. Hemoglobin concentration and hematocrit values did not differ significantly between treated patients and untreated controls. However, after illumination during 24 h (real exposure time 12 h) with a highly effective NC 400-04 Narva lamp, we found a completely reversible decrease of the mean erythrocyte diameters. The changes were statistically significant at the 8th day of life and disappeared up to the 16th day after birth. Riboflavin administration immediately before starting the phototherapy was able to prevent this phenomenon. The glutathione reductase activity (method by BEUTLER) was not affected, neither by phototherapy alone nor by riboflavin administered additively. As a conclusion of our results we would like to recommend a general riboflavin substitution in newborns after phototreatment.
mesh_terms: D004899:Erythroblastosis, Fetal / Q000628:therapy*; D004912:Erythrocytes / Q000502:physiology*; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D008027:Light; D010789:Phototherapy; D011247:Pregnancy; D012256:Riboflavin / Q000627:therapeutic use
chemical_list: D006454:Hemoglobins; D012256:Riboflavin
vernacular_title: Zur Frage photodynamischer Schäden an Erythrozyten unter Blaulichttherapie bei Icterus neonatorum.