[Antineoplastic activity of lambdamycin in different murine test models compared with cyclophosphamide, 6-mercaptopurine and 5-fluorouracil (author's transl)].
Lambdamycin, a chromoglycoside antibiotic like chartreusin was found to be very active against leukemias L 1210 and P 388 and moderate effective against melanoma B 16 and Lewis lung carcinoma of mice. It was nearly without any effect when tested on Walker 256 carcinoma of rats. The effectiveness of lambdamycin was compared with that of cyclophosphamide, 5-fluorouracil and 6-mercaptopurine.
D000818:Animals; D001578:Benzopyrans; D002277:Carcinoma / Q000188:drug therapy; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005472:Fluorouracil / Q000627:therapeutic use*; D006027:Glycosides / Q000627:therapeutic use*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008545:Melanoma / Q000188:drug therapy; D015122:Mercaptopurine / Q000627:therapeutic use*; D051379:Mice; D051381:Rats
D001578:Benzopyrans; D006027:Glycosides; D003520:Cyclophosphamide; D015122:Mercaptopurine; C002185:chartreusin; D005472:Fluorouracil
Antineoplastische Wirksamkeit von Lambdamycin an verschiedenen murinen Testmodellen im Vergleich zur Wirkung von Cyclophosphamid, 6-Mercaptopurin and 5-Fluoruracil.