[Aspartate aminotransferase activity in the brain and spinal cord in acute and chronic alcoholic intoxication].
Resynthesis of aspartate via glutamate was decreased 6-8-fold in rat brain spinal cord tissues due to distinct inhibition of aspartate aminotransferase in acute alcohol intoxication. Consumption of glutamic acid was distinctly increased 1.5-2-fold in tissues of the central nervous system but its metabolism was altered. Normalization occurred within 12-24 hrs after the intake of alcohol. In the state of chronic alcohol intoxication the enzymatic activity was marked increased in brain and spinal cord; in this case the response to a single alcohol administration was altered as compared with acute alcohol intoxication.
D000435:Alcoholic Intoxication / Q000201:enzymology* / Q000378:metabolism; D000437:Alcoholism / Q000201:enzymology; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism*; D001224:Aspartic Acid / Q000032:analysis; D001921:Brain / Q000201:enzymology*; D001923:Brain Chemistry; D005971:Glutamates / Q000032:analysis; D006801:Humans; D008297:Male; D051381:Rats; D013116:Spinal Cord / Q000032:analysis / Q000201:enzymology*; D013997:Time Factors
D005971:Glutamates; D001224:Aspartic Acid; D001219:Aspartate Aminotransferases
Aktivnost' aspartat-aminotransferazy v golovnom i spinnom mozge pri ostroĭ i khronicheskoĭ alkogol'noĭ intoksikatsii.