title: Anti-oxidative effects of vitamin B2-butyrate on the cardiac mitochondrial disorders induced by adriamycin.
abstract: The combined use of CoQ10 with adriamycin has been recommended for reduction of the cardiotoxicity that occurs during cancer chemotherapy. Vitamin B2-butyrate was also investigated in order to determine anti-oxidative effects on adriamycin cardiotoxicity. This vitamin analysis prevented enhanced lipid peroxidation and rectified the respiratory disorders of heart mitochondria induced by adriamycin, however, the deficiency of the CoQ10-pool was not rectified. The combined approach of using CoQ10 for rectifying the deficiency of this component and of using B2-butyrate for reducing lipid peroxidation was indicated for adriamycin cancer chemotherapy.
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D003067:Coenzymes; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D008054:Lipid Peroxides / Q000032:analysis; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D012256:Riboflavin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000172:deficiency / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D003067:Coenzymes; D008054:Lipid Peroxides; D014451:Ubiquinone; D004317:Doxorubicin; C024989:coenzyme Q10; C009175:riboflavin tetrabutyrate; D012256:Riboflavin