title: Intrauterine growth retardation. A report of two cases with bird-headed appearance, skeletal changes and peripheral GH resistance.
abstract: Two cases of severe intrauterine growth retardation, a boy and a girl studied for 7 and 10 years respectively, are reported. Both patients showed peculiar cranio-facial abnormalities as observed in the so-called Seckel's syndrome, an appearance of premature aging, peripheral GH resistance which was probably due to deficiency in Somatomedin A production, sella areas and volumes consistently at the upper limits of normal when related to the patients' height, and dysharmonic skeletal maturation ivory cone-shaped epiphyses of the tubular bones of the hands.
mesh_terms: D001846:Bone Development; D002648:Child; D003394:Craniofacial Dysostosis / Q000175:diagnosis; D004351:Drug Resistance; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis*; D013006:Growth Hormone; D006225:Hand / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D011247:Pregnancy; D011859:Radiography; D013002:Somatomedins / Q000172:deficiency
chemical_list: D013002:Somatomedins; D013006:Growth Hormone