Regulation by testosterone of the glucosamine-6-phosphate synthase activity in the male reproductive organs of rat.
Accessory reproductive organs of male rat were found to contain high activities of glucosamine-6-phosphate synthase (glucosaminephosphate isomerase (glutamine-forming), EC 5.3.1.19). Castration caused drastic reduction (75%) in the enzyme activity of ventral prostate. Testosterone propionate administration restored the enzyme activity while cortisol and estradiol-17 beta did not cause any effect. Cycloheximide blocked the stimulation caused by testosterone.
D000818:Animals; D002238:Carbohydrate Epimerases / Q000378:metabolism*; D002369:Castration; D003513:Cycloheximide / Q000494:pharmacology; D004822:Epididymis / Q000201:enzymology; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / Q000378:metabolism*; D008297:Male; D011467:Prostate / Q000201:enzymology; D051381:Rats; D012669:Seminal Vesicles / Q000201:enzymology; D013737:Testis / Q000201:enzymology; D013739:Testosterone / Q000378:metabolism*
D013739:Testosterone; D003513:Cycloheximide; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); D002238:Carbohydrate Epimerases