Antifungal activity of fenticonazole in experimental dermatomycosis and candidiasis.
The antifungal activity of alpha-(2,4-dichlorophenyl)-beta,N-imidazolylethyl 4-phenylthiobenzyl ether nitrate (fenticonazole, Rec 15/1476) in experimental dermatomycosis and candidiasis in guinea pigs was studied. Fenticonazole proved to be a very active drug with a healing capacity generally higher than that of the reference compounds. The adequate range of activity was from 1% to 3%, giving complete healing without relapses in 100% of cases treated. Fenticonazole is presently undergoing further experimental studies and on the basis of our results a clinical trial would therefore seem to be essential.
D000818:Animals; D000935:Antifungal Agents; D002177:Candidiasis / Q000188:drug therapy*; D003022:Clotrimazole / Q000627:therapeutic use; D003881:Dermatomycoses / Q000188:drug therapy*; D006168:Guinea Pigs; D007093:Imidazoles / Q000627:therapeutic use*; D008825:Miconazole / Q000627:therapeutic use
D000935:Antifungal Agents; D007093:Imidazoles; D008825:Miconazole; D003022:Clotrimazole; C033486:fenticonazole