Fetal mortality associated with cleft lip and cleft palate.
Analysis of 1,516 pregnancies in sibships of probands with cleft lip with or without cleft palate [CL(P)], and 774 pregnancies in those of probands with isolated cleft palate (CP) indicated that fetal mortality significantly increases with liability to clefting. These data are compatible with the multifactorial two-threshold model, according to which a lower threshold level of liability results in a cleft formation whereas a higher level of liability causes a fetal death.
D002971:Cleft Lip / Q000150:complications / Q000235:genetics; D002972:Cleft Palate / Q000150:complications / Q000235:genetics; D005260:Female; D005315:Fetal Diseases / Q000401:mortality*; D006801:Humans; D008297:Male; D008954:Models, Biological; D011247:Pregnancy; D012744:Sex Ratio