title: Muscle cell leakage due to long distance training.
abstract: Abnormal myoglobinemia (above 77 microgram/l) and free hemoglobin in plasma were found in 16 runners and in nine non runners immediately following distance running. The same abnormalities were found iun six elite rowers following rowing. In parallel with the rise in myoglobin and free hemoglobin a rise was found in serum concentrations of cellular enzymes (LDH, CK, ASAT, alkaline phosphatase) and of various metabolites. We found no proteinuria nor casts in the urine. Non runners had a higher rise in serum myoglobin than runners. Competitive running caused a rise in the serum concentration of the heart specific fraction of creatine kinase in seven of the nine (healthy) elite runners. The abnormal findings are only explainable on the basis of leakage of proteins from muscle cells to the circulation in otherwise healthy, well trained persons. Myoglobinemia and a transient rhabdomyolysis is a common phenomenon in long distance running, but evidently also occurs in distance rowing. Three months of running training prevented most of the muscle damage from relaxed jogging in the nine previous non runners. Neither the observed myoglobinemia nor the hemoglobinemia resulted in any significant loss of iron in the urine.
mesh_terms: D000328:Adult; D002463:Cell Membrane Permeability; D003402:Creatine Kinase / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000201:enzymology; D009211:Myoglobin / Q000097:blood*; D009212:Myoglobinuria; D005082:Physical Exertion; D012420:Running; D012508:Sarcolemma / Q000648:ultrastructure; D013178:Sports Medicine; D013997:Time Factors
chemical_list: D006454:Hemoglobins; D007527:Isoenzymes; D009211:Myoglobin; D003402:Creatine Kinase