[Autoradiographic and electron-microscopic analysis of sympathetic neurocytes in rats of different ages after partial chemical sympathectomy].
Neurocytes of the cranial cervical sympathetic ganglion have been studied in normally developing and partly guanidine-desympathized rats at 1 and 12 months of age. In ganglia of the both age groups less than 20% of the cells are preserved. But the somatic development of the animals does not change, and an average volume of the neural cells in the experiment exceeds that of the control. At the age of 1 month in the experimental rats the incorporation of the protein biosynthesis labelled precursor in the neural cells increases, as does its amount evacuated into the terminals at a slow rate. Together with some ultrastructural rearrangements in the perikaryons it could demonstrate certain hyperplastic processes that are possibly directed towards an increased adrenergic innervation in the periphery at the expense of growing processes. Age changes in all the rats occur similarly, nevertheless, certain acceleration of the age dynamics is observed in the partly desympathized animals.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography; D005728:Ganglia, Sympathetic / Q000473:pathology*; D006145:Guanethidine; D008854:Microscopy, Electron; D009474:Neurons / Q000473:pathology* / Q000648:ultrastructure; D051381:Rats; D013563:Sympathectomy, Chemical
D006145:Guanethidine
Radioavtograficheskiĭ i élektronno-mikroskopicheskiĭ analiz simpaticheskikh nevrotsitov posle chastichnoĭ khimicheskoĭ desimpatizatsii krys raznogo vozrasta.