Non-competitive inhibition of angiotensin II and PGE2 on guinea-pig ileum with streptomycin, vitamin K3 and rutin.
The agonistic actions of angiotensin II and prostaglandin E2 (PGE2) were plotted on the guinea-pig ileum as cumulative dose-response curves. The same actions were also studied in the presence of vitamin K3,, streptomycin and rutin which antagonized each of the agonists non-competitively. By comparison of the affinity constants of antagonists, it was determined that the antagonism occurs by a common mechanism.
D000804:Angiotensin II / Q000037:antagonists & inhibitors*; D000818:Animals; D001667:Binding, Competitive; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D011458:Prostaglandins E / Q000037:antagonists & inhibitors*; D012431:Rutin / Q000494:pharmacology*; D013307:Streptomycin / Q000494:pharmacology*; D014812:Vitamin K / Q000494:pharmacology*
D011458:Prostaglandins E; D000804:Angiotensin II; D014812:Vitamin K; D012431:Rutin; D013307:Streptomycin