title: [Investigations on the general effects of tinofedrine on heart and blood circulation (author's transl)].
abstract: In anesthetized dogs, (+)-(R)-alpha ((S)-1-[(3,3-di-3-thienylallyl)amino]-ethyl)-benzylalcohol hydrochloride (tinofedrine hydrochloride, D 8955) causes a remarkable increase of cardiac output by positive inotropic and chronotropic stimulation of the heart and simultaneous reduction of peripheral vascular resistance. The effect is antagonized by beta-adrenergic blocking drugs. In comparison with typical beta-agonists (e.g., orciprenaline) tinofedrine at inotropically equieffective doses, has a much weaker effect on the heart rate. Measurement of tissue blood flow by radioactive tracer microspheres after tinofedrine exhibited a rather homogeneous increased perfusion in all parts of the brain, as well as myocardium, kidneys and liver. In coronary circulation tinofedrine causes vasodilation so that in a therapeutic dose range increased work load is equalized by a sufficient myocardial supply. Tinofedrine itself neither caused a disturbance of heart rhythm nor worsened aconitine-induced arrhythmias in anesthetized rats. Simultaneous application of digoxin or diazepam did not influence the action of tinofedrine; there was no evidence of any incompatibility of such combinations. Experiments with a possible metabolite (l-norephedrine) showed that it is not involved in the action of tinofedrine.
mesh_terms: D000758:Anesthesia; D000818:Animals; D000889:Anti-Arrhythmia Agents; D003326:Coronary Circulation / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology; D004077:Digoxin / Q000494:pharmacology; D004285:Dogs; D004347:Drug Interactions; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D012039:Regional Blood Flow / Q000187:drug effects; D013876:Thiophenes / Q000494:pharmacology*
chemical_list: D000889:Anti-Arrhythmia Agents; D013876:Thiophenes; D004077:Digoxin; C018159:tinofedrine; D003975:Diazepam
vernacular_title: Untersuchungen zur allgemeinen Herz- und Kreislaufwirkung des Tinofedrin.