[Role of folic acid and its amino derivatives in the mechanism of action of low doses of formaldehyde on the organs].
The presence of the relationship between the content of formaldehyde and folic acid in solution and tissue has been studied. It has been demonstrated that folic acid and its amino derivatives reduce the content of formaldehyde in solution by over 50%. During the build up of the increased content of folic acids and its analogs, there takes place diminution of the content of exogenous formaldehyde in all the test organs. This was interpreted as evidence of a close interplay with folic acid metabolism as regards the mechanism of action of exogenous formaldehyde introduced with a purpose of organ conservation.
D000630:Aminopterin / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D005260:Female; D005492:Folic Acid / Q000378:metabolism* / Q000494:pharmacology; D005557:Formaldehyde / Q000378:metabolism* / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008727:Methotrexate / Q000378:metabolism / Q000494:pharmacology; D009926:Organ Preservation; D051381:Rats; D014018:Tissue Distribution
D005557:Formaldehyde; D005492:Folic Acid; D000630:Aminopterin; D008727:Methotrexate
Rol' folievoĭ kisloty i ee aminoproizvodnykh v mekhanizme deĭstviia nizkikh doz formal'degida na organy.