title: Stimulation by potassium of cholesterol ester depletion of rat zona glomerulosa cells in vitro.
abstract: The relationship between cholesterol metabolism and steroidogenesis by rat zona glomerulosa cells in vitro was examined by study of the changes in the cellular content of free- and esterified-cholesterol duing basal and K+-stimulated steroidogenesis, K+-stimulation was associated with an increased rate of depletion of cellular esterified-cholesterol, in the absence of any significant change in free-cholesterol levels. These data suggest that cholesterol for steroidogenesis by rat zona glomerulosa cells in vitro is supplied by hydrolysis of endogenous stores of esterified-cholesterol.
mesh_terms: D000311:Adrenal Glands / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002788:Cholesterol Esters / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D007700:Kinetics; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002788:Cholesterol Esters; D011188:Potassium