Bombesin inhibits stress-induced eating.
Bombesin administered both intracerebroventricularly and parenterally suppressed stress-induced eating in the rat (using mild tail pinch model). Intraventricular administration of bombesin resulted in hyperglycemia, which was abolished by adrenalectomy. The satiety-inducing effect of bombesin was independent of the hyperglycemia it produces as suppression of stress-induced eating was still present in adrenalectomized animals.
D000315:Adrenalectomy; D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects*; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced; D008297:Male; D009496:Neurotensin / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D013315:Stress, Psychological / Q000503:physiopathology*
D010455:Peptides; D009496:Neurotensin; D001839:Bombesin