Anti-oxidative effects of vitamin B2-butyrate on the cardiac mitochondrial disorders induced by adriamycin.
The combined use of CoQ10 with adriamycin has been recommended for reduction of the cardiotoxicity that occurs during cancer chemotherapy. Vitamin B2-butyrate was also investigated in order to determine anti-oxidative effects on adriamycin cardiotoxicity. This vitamin analysis prevented enhanced lipid peroxidation and rectified the respiratory disorders of heart mitochondria induced by adriamycin, however, the deficiency of the CoQ10-pool was not rectified. The combined approach of using CoQ10 for rectifying the deficiency of this component and of using B2-butyrate for reducing lipid peroxidation was indicated for adriamycin cancer chemotherapy.
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D003067:Coenzymes; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D008054:Lipid Peroxides / Q000032:analysis; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D012256:Riboflavin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000172:deficiency / Q000494:pharmacology
D000975:Antioxidants; D003067:Coenzymes; D008054:Lipid Peroxides; D014451:Ubiquinone; D004317:Doxorubicin; C024989:coenzyme Q10; C009175:riboflavin tetrabutyrate; D012256:Riboflavin