Low plasma cortisol and hematologic abnormalities associated with essential fatty acid deficiency in man.
A case of probable adrenal insufficiency (glucocorticoid only) with hematologic changes including eosinophilia, neutropenia, and red blood cell abnormalities developed in the course of prolonged, fat-free feeding. The coincident development of essential fatty acid deficiency was conformed by serum fatty acid profiles indicating the presence of abnormal amounts of eicosatrienoic acid, and a triene/tetraene ratio greater than 0.4; all these findings responded to fat repletion. The association of glucocorticoid deficiency, neutropenia, and eosinophilia with essential fatty acid deficiency has not been previously reported in humans.
D015065:17-Hydroxycorticosteroids / Q000652:urine; D000328:Adult; D001772:Blood Cell Count; D005228:Fatty Acids, Essential / Q000172:deficiency*; D005260:Female; D006402:Hematologic Diseases / Q000209:etiology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D010195:Pancreatitis / Q000150:complications; D013997:Time Factors
D015065:17-Hydroxycorticosteroids; D005228:Fatty Acids, Essential; D006854:Hydrocortisone