[Classification of xenobiotics according to their effect on mitochondrial enzymatic systems].
The author reviews his own and reported data on the action of toxic substances of varying chemical classes on the main stages of the process of oxidative phosphorylation. It has been shown that toxic substances can destroy oxidative phosphorylation by the following ways: by reducing the resistance of mitochondrial membranes (disconnectors of the protonophoric and ionophoric types); by inhibiting dehydrogenase activity; by disturbing electron transfer via the respiratory chain; by disordering transmembrane transport of cations or anions; by inhibiting ATPase activity. The characteristic classes of toxic substances and the most specific inhibitors are indicated for each of the points enumerated. It is pointed out that the most incident reasons for impairment of oxidative phosphorylation are inhibition of NAD X H-dehydrogenase and protonophoric dissociation of respiration and phosphorylation.
D000818:Animals; D064420:Drug-Related Side Effects and Adverse Reactions; D066298:In Vitro Techniques; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology*; D009243:NAD; D010085:Oxidative Phosphorylation; D010088:Oxidoreductases / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000145:classification; D051381:Rats
D004364:Pharmaceutical Preparations; D009243:NAD; D010088:Oxidoreductases
Klassifikatsiia ksenobiotikov po lokalizatsii ikh deĭstviia na fermentnye sistemy mitokhondriĭ.