title: On the heritability of serum high density lipoprotein in twins.
abstract: To estimate the relative contributions of hereditary vs. environmental factors in the variation of high density lipoprotein, we measured the concentrations of its main apoprotein components, apoprotein A-I (apo A-I) and apoprotein A-II (apo A-II), in serum samples from 65 monozygotic (MZ) and 70 dizygotic (DZ) like-sexed twin pairs. Evidence for a genetic component of variance was found for apo A-II, giving heritability (h2) estimates of .35 and .30 for males and females, respectively. No genetic contribution to the variance of apo A-I could be demonstrated. Additionally, males had lower concentrations of apo A-I, but higher of apo A-II, than females.
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001053:Apolipoproteins / Q000097:blood / Q000235:genetics; D005260:Female; D005387:Finland; D014644:Genetic Variation; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D012621:Seasons; D012737:Sex Factors; D014427:Twins
chemical_list: D001053:Apolipoproteins; D008075:Lipoproteins, HDL