Elimination kinetics of isoniazid in the newborn infant.
The elimination of isoniazid was followed in 2 newborn infants who had received the drug transplacentally, and in 1 of the mothers. The half-time for serum elimination for mother No. 1, babies No. 1 and 2 were calculated as 3.0, 7.8 and 19.8 h, respectively. Near equality existed between maternal and newborn serum isoniazid concentrations. Additional studies are required to determine the acetylation capacity of newborns.
D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007538:Isoniazid / Q000378:metabolism* / Q000627:therapeutic use; D007700:Kinetics; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy; D014376:Tuberculosis / Q000188:drug therapy
D007538:Isoniazid