The effects of the administration of beta-phenylethylamine on tyramine metabolism.
The concentrations of p-tyramine (p-TA), m-tyramine (m-TA), dopamine (DA) and their principal metabolites, p-hydroxyphenylacetic acid (p-HPAA), m-hydroxyphenylacetic acid (m-HPAA) and homovanillic acid (HVA) were determined in the corpus striatum of Swiss mice at various times after the subcutaneous administration of beta-phenylethylamine (PE) (50 mg/kg). Initially p-TA concentrations were reduced but rapid synthesis was apparent up to 2 h after PE administration. PE treatment increased m-TA and these increases reached significance at 1 and 8 h. PE caused a bimodal increase in p-HPAA and m-HPAA concentrations with the first peak observed at 0.5-1 h due to initial release of p-TA and m-TA. Rapid synthesis of p-TA and m-TA resulted in increased acid concentrations at 4 h. HVA concentrations were increased up to 1 h after PE administration. The synthesis of p-TA and m-TA is related to that of DA probably as a result of the activation of tyrosine hydroxylase. PE may serve as a precursor for p-TA synthesis when the endogenous PE concentration is greatly elevated.
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D006719:Homovanillic Acid / Q000378:metabolism; D007536:Isomerism; D008297:Male; D051379:Mice; D010627:Phenethylamines / Q000494:pharmacology*; D010648:Phenylacetates / Q000378:metabolism; D013997:Time Factors; D014439:Tyramine / Q000378:metabolism*
D010627:Phenethylamines; D010648:Phenylacetates; C029261:phenethylamine; C008070:4-hydroxyphenylacetic acid; C028169:3-tyramine; C008069:3-hydroxybenzeneacetic acid; D004298:Dopamine; D006719:Homovanillic Acid; D014439:Tyramine