title: The influence of various chemical additives on the survival of vesicular exanthema virus in aerosols.
abstract: The influence of relative humidity (r.h.) on the survival of vesicular exanthema virus (VEV) in aerosols at I s and during the next 5 min when generated from phosphate buffer solution containing polyhydroxy compounds, dimethyl sulphoxide, salt or protein has been examined. VEV was sensitive to r.h. in the range of 40 to 60% in the presence of bovine serum albumin, glucose, inositol or phosphate buffer. Addition of sodium chloride stabilized the virus in aerosols at mid-range r.h. both immediately after generation and after a period of storage for 5 min. In the presence of dimethyl sulphoxide or glycerol, virus survival was reduced at 20% r.h. at I s and at all r.h. during the first 5 min. Pre-humidification did not produce any significant difference in virus recovery.
mesh_terms: D000336:Aerosols; D000818:Animals; D002139:Caliciviridae / Q000254:growth & development*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D005990:Glycerol / Q000494:pharmacology; D006813:Humidity; D007294:Inositol / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology; D013552:Swine; D014720:Vesicular Exanthema of Swine / Q000382:microbiology
chemical_list: D000336:Aerosols; D012710:Serum Albumin, Bovine; D012965:Sodium Chloride; D007294:Inositol; D005947:Glucose; D005990:Glycerol; D004121:Dimethyl Sulfoxide