Norepinephrine and gamma-aminobutyric acid in amyotrophic lateral sclerosis.
Patients with amyotrophic lateral sclerosis have increased levels of the neutrotransmitter norepinephrine in blood and cerebrospinal fluid and depressed levels of the inhibitory neurotransmitter gamma-aminobutyric acid in cerebrospinal fluid. These neurochemical alterations are most marked in patients bedridden with advanced disease, appear interrelated, and lead to cardiovascular alterations in patients with amyotrophic lateral sclerosis.
D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D009135:Muscular Diseases / Q000097:blood / Q000134:cerebrospinal fluid; D009422:Nervous System Diseases / Q000097:blood / Q000134:cerebrospinal fluid; D009638:Norepinephrine / Q000097:blood / Q000134:cerebrospinal fluid*; D005680:gamma-Aminobutyric Acid / Q000097:blood / Q000134:cerebrospinal fluid*
D005680:gamma-Aminobutyric Acid; D009638:Norepinephrine