title: Inhibition of adenosine deaminase by deaza derivatives of adenosine and purine riboside.
abstract: Deaza analogs of adenosine, where carbon substitutes for nitrogen, are not substrates for adenosine deaminase (adenosine aminohydrolase EC 3.5.4.4); little is reported on their ability to be inhibitors. Among the deaza analogs of adenosine and purine riboside that we have been testing, 1-deazaadenosine proved to be the best inhibitor (Ki = 6.6 X 10(-7)M). 1-deazapurine riboside, 1,3-dedeazadenosine, 3-deazaadenosine have affinity by about two and three order of magnitude lower.
mesh_terms: D058892:Adenosine Deaminase Inhibitors; D000818:Animals; D002417:Cattle; D007422:Intestines / Q000187:drug effects / Q000201:enzymology; D007700:Kinetics; D009700:Nucleoside Deaminases / Q000037:antagonists & inhibitors*; D012263:Ribonucleosides / Q000494:pharmacology*; D014372:Tubercidin / Q000031:analogs & derivatives / Q000494:pharmacology*
chemical_list: D058892:Adenosine Deaminase Inhibitors; D012263:Ribonucleosides; D009700:Nucleoside Deaminases; D014372:Tubercidin