title: Histamine poisoning in tuberculous patients after ingestion of tuna fish.
abstract: Two cases of histamine poisoning after ingestion of tuna fish occurred in tuberculous patients. The symptoms and circumstances leading to the reaction were identical to those previously reported for 2 other varieties of fish, skipjack and Sardinella (Amblygaster) sirm. Isoniazid, which is an invariable constituent of any antituberculous drug regimen, is a potent histamine inhibitor. When tuna fish, which has a high histamine content, is eaten, the histamine concentration in the tissues tends to increase, producing features of histamine intoxication.
mesh_terms: D000328:Adult; D000818:Animals; D004347:Drug Interactions; D005260:Female; D005399:Fishes; D005517:Foodborne Diseases / Q000209:etiology*; D006632:Histamine / Q000506:poisoning*; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D014388:Tuberculosis, Lymph Node / Q000188:drug therapy*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*; D014413:Tuna
chemical_list: D006632:Histamine; D007538:Isoniazid