title: [Effect of psychotropic agents on the manifestation of the morphine abstinence syndrome in mice].
abstract: Abstinence syndrome pattern produced by withdrawal of morphine injections in doses of 240 mg/kg daily was studied in experiments on mice. Pirroksan, butyroxan and carbidine (10 mg/kg intraperitoneally) inhibited manifestations of morphine withdrawal in an "open field" situation and depressed jumping activity. Phenazepam (20 mg/kg) depressed emotional hyperactivity in abstinent animals.
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents; D001522:Behavior, Animal / Q000187:drug effects; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000627:therapeutic use; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002243:Carbolines / Q000627:therapeutic use; D004146:Dioxanes / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008297:Male; D051379:Mice; D009021:Morphine Dependence / Q000188:drug therapy*; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D011759:Pyrrolidines / Q000627:therapeutic use; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D002243:Carbolines; D004146:Dioxanes; D011619:Psychotropic Drugs; D011759:Pyrrolidines; D001569:Benzodiazepines; C017928:phenazepam; C021293:butyroxan; C009143:proroxan
vernacular_title: Vliianie nekotorykh psikhotropnykh sredstv na proiavleniia morfinnogo abstinentnogo sindroma u mysheĭ.