The penetration of flucloxacillin into cortical and cancellous bone during arthroplasty of the knee.
Antibiotic prophylaxis with 2 g flucloxacillin was given 2 h before operation in 23 adult patients undergoing knee replacement operations for rheumatoid arthritis or osteoarthrosis. The mean extracted concentration of flucloxacillin obtained at operation was 12.9 micrograms/ml (SD 5.25) in synovial fluid; 2.9 micrograms/g (SD 3.59) in synovium; 2.0 micrograms/g (SD 1.48) in cancellous bone and 1.3 micrograms/g (SD 1.25) in cortical bone. The minimum inhibiting concentration (MIC) value for flucloxacillin was usually 0.25 micrograms/g against Staphylococcus aureus. Therapeutically active concentrations were thus obtained. There were no adverse reactions from the antibiotic administration.
D000328:Adult; D000368:Aged; D001842:Bone and Bones / Q000378:metabolism*; D003023:Cloxacillin / Q000031:analogs & derivatives*; D005260:Female; D005436:Floxacillin / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D011292:Premedication; D013582:Synovial Fluid / Q000378:metabolism; D013583:Synovial Membrane / Q000378:metabolism*; D014018:Tissue Distribution
D005436:Floxacillin; D003023:Cloxacillin