The bile acid binding and hypocholesterolemic action of two water-soluble polymers.
The in vitro bile acid binding properties of 2 water-soluble, linear, cationic resins, poly-[(dimethylimino)trimethylene chloride] or 3,3-ione C1, and poly-diallyldimethylammonium chloride) or CAT-FLOC were determined. Both polymers were substantially more active than cholestyramine. All were compared for hypocholesterolemic effect in normo-cholesterolemic dogs. CAT-FLOC and 3,3-ionene C1, administered at 1.8 and 1.2 g/day, respectively, exhibited cholesterol-lowering action equivalent to cholesteryramine given at 12 g/day. The results of this study suggest that effective reduction of plasma cholesterol may be achieved with significantly lower doses of bile acid sequestrants.
D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D001665:Binding Sites; D002411:Cation Exchange Resins / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood*; D002792:Cholestyramine Resin / Q000627:therapeutic use; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D066298:In Vitro Techniques; D007475:Ion Exchange Resins / Q000627:therapeutic use*; D008297:Male; D011095:Polyethylenes; D011108:Polymers / Q000627:therapeutic use*; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use*; D012995:Solubility; D013656:Taurocholic Acid / Q000378:metabolism*
D000924:Anticholesteremic Agents; D002411:Cation Exchange Resins; D007475:Ion Exchange Resins; D011095:Polyethylenes; D011108:Polymers; D000644:Quaternary Ammonium Compounds; D002792:Cholestyramine Resin; C041004:poly-N,N-dimethyl-N,N-diallylammonium chloride; C028023:3,3-ionene; D013656:Taurocholic Acid; D002784:Cholesterol