Biophysical and electrophysiological studies of hexanedione neurotoxicity.
This study examined the significance of nerve microviscosity changes which occur in 2,5-hexanedione (2,5-HD) neurotoxicity. To establish a correlation between microviscosity changes and neuronal damage, a standard axonal neuropathy (nerve section) was employed. Electrophysiological studies of the sciatic-tibial nerve of rats were carried out to detect the onset of nerve damage. Also, because 2,5-HD may affect membranes in general, with nerve membranes being the most sensitive, red blood cell ghost membranes were prepared from 2,5-HD treated animals and tested for viscosity changes. Results of these studies suggest that 2,5-HD and nerve section have similar effects on myelin microviscosity.
D000818:Animals; D004576:Electromyography; D004910:Erythrocyte Membrane / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects*; D005453:Fluorescence; D006588:Hexanones / Q000633:toxicity*; D007659:Ketones / Q000633:toxicity*; D008297:Male; D009186:Myelin Sheath / Q000187:drug effects*; D009410:Nerve Degeneration / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects*; D009431:Neural Conduction / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014783:Viscosity
D006588:Hexanones; D007659:Ketones; C011269:2,5-hexanedione