[Study on administration method of dibekacin].
The serum concentration of dibekacin (DKB) were determined in 4 healthy adult volunteers after intramuscular injection, intravenous injection and 1-hour or 2-hour intravenous drip infusion of 100 mg of DKB, and 1-hour drip infusion of 50 mg. The mean peak concentration after the 2-hour drip infusion of 100 mg of DKB was a rather low level. While the 1-hour drip infusion of 50 mg of DKB produced a peak concentration of 7.9 micrograms/ml, which is comparable to that after intramuscular injection of 100 mg. In the cases of the 1-hour drip infusion of 100 mg, the peak serum level reached 13.3 micrograms/ml, which is a relatively higher level than that after intramuscular injection of the same dose. Based on the above findings, it is suggested that the 1-hour intravenous drip infusion of DKB in doses of 50 mg to 100 mg be practically applied for therapeutic use.
D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood; D003982:Dibekacin / Q000008:administration & dosage* / Q000097:blood; D006801:Humans; D007263:Infusions, Parenteral; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007612:Kanamycin / Q000031:analogs & derivatives*; D007710:Klebsiella Infections / Q000382:microbiology; D008168:Lung / Q000382:microbiology; D008297:Male; D051379:Mice; D011014:Pneumonia / Q000382:microbiology
D000900:Anti-Bacterial Agents; D003982:Dibekacin; D007612:Kanamycin