Effect of Mn++ on blood sugar level in rats.
Mn++ produced hypoglycemia in normal rats. The effect was dose-dependent. However, Mn++ did not produce hypoglycemia in alloxan-treated rats. There was a rise in liver glycogen following Mn++ treatment which was correlated with fall in blood sugar at 1 1/2 and 3 hr. There was also increase in the glucose uptake by rat diaphragm upto 47% between 2 and 3 hr. The results suggest that functioning, intact pancreatic beta-cells are necessary for the action of Mn++ and that Mn++ may have a peripheral effect on glucose entry into the cells.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000378:metabolism; D003964:Diaphragm / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism; D007003:Hypoglycemia / Q000139:chemically induced; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D008345:Manganese / Q000494:pharmacology*; D051381:Rats
D001786:Blood Glucose; D008112:Liver Glycogen; D008345:Manganese; D005947:Glucose