Resistance to adjuvant arthritis induced by a genetic mutation, osteopetrosis.
Adjuvant arthritis stands as the closest model to human rheumatoid arthritis. A genetic mutation (op) recognized to provoke osteopetrosis in rats, completely inhibits their ability to develop adjuvant arthritis. Osteopetrosis in the op mutant is linked to deficiencies in T-lymphocytes and macrophages functions. Therefore this animal model may be helpful for a better understanding of the immunoregulation impairment involved in adjuvant arthritis.
D000818:Animals; D001168:Arthritis / Q000276:immunology*; D001169:Arthritis, Experimental / Q000235:genetics / Q000276:immunology*; D005260:Female; D007113:Immunity, Innate; D008297:Male; D009154:Mutation; D010022:Osteopetrosis / Q000235:genetics / Q000276:immunology*; D051381:Rats; D011922:Rats, Mutant Strains; D013997:Time Factors