The dynamics of changes in the phosphorolytic and hydrolytic activity in the myocardium and skeletal muscle during adrenaline infusion.
Rats were given adrenaline in continuous intravenous infusion at a rate of 10 micrograms/kg/min for 5 and 8 minutes. The phosphorolytic and hydrolytic activity in the myocardium and skeletal muscle was determined by the method of simultaneous measurements at one-minute intervals. In the adrenalectomized rats the effect of the adrenaline-hydrocortisone interaction on these activities was investigated. The obtained results confirmed the validity of the hypothesis about a correlation between the changes in the amylolytic activity and the phosphorolytic activity, and demonstrated that this correlation was not changed by glycocorticosteroids. A significant temporal correlation was found between the dynamics of the mutually opposite changes in both these glycogenolytic activities. The hypothesis of a competition between amylolysis and glycogen phosporolysis is discussed assuming that this would help in the maintenance of a relative equilibrium between glycogen biosynthesis and breakdown.
D000315:Adrenalectomy; D000818:Animals; D004837:Epinephrine / Q000008:administration & dosage* / Q000494:pharmacology; D006868:Hydrolysis; D007263:Infusions, Parenteral; D009132:Muscles / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D010766:Phosphorylation; D051381:Rats; D011919:Rats, Inbred Strains
D004837:Epinephrine