[Intracerebroventricular administration of cholecystokinin inhibits the dopamine- and serotoninergic systems of the brain].
In male Wistar rats, intraventricular administration of cholecystokinin caused specific dose-dependent behavioral changes: low doses (0.1--0.25 U) depressed the exploratory activity whereas higher doses (0.5--8.0 U) caused head twitches, stereotyped gnawing and hyperreactivity. Cholecystokinin suppressing markedly dopamine and serotonin turnover in various brain structures, completely blocked the behavioral effects of amphetamine (2.5 mg/kg) and 5-hydroxytryptophan (150 mg/kg). The data obtained suggest that cholecystokinin suppresses presynaptic dopamine- and serotoninergic mechanisms but enhances the sensitivity of postsynaptic receptors of these systems.
D000818:Animals; D001522:Behavior, Animal; D001933:Brain Stem / Q000378:metabolism; D002766:Cholecystokinin / Q000494:pharmacology / Q000502:physiology*; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D008032:Limbic System / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D013378:Substantia Nigra / Q000378:metabolism
D012701:Serotonin; D002766:Cholecystokinin; D004298:Dopamine
Intratserebroventrikuliarnoe vvedenie kholetsistokinina ugnetaet aktivnost' dofamin- i serotoninergicheskoĭ sistem mozga.