Heroin "overdose" death: contribution of drug-associated environmental cues.
A model of "overdose" deaths among heroin addicts is proposed which emphasizes recent findings concerning the contribution of drug-associated environmental cues to drug tolerance. Results of animal experiments performed to evaluate this model suggest that conditioned drug-anticipatory responses, in addition to pharmacological factors, affect heroin-induced mortality.
D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D004777:Environment; D003932:Heroin / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051381:Rats; D019966:Substance-Related Disorders / Q000503:physiopathology*
D003932:Heroin