[Urinary excretion of blastomogenic tryptophan metabolites in tubazide- and phthivazid-treated patients].
The levels of tryptophan metabolites in the urine of 30 isoniazid--and phthivazid--treated patients with tuberculosis and 25 healthy subjects were determined by paper chromatography. The urine of healthy subjects was found to contain tryptophan, indican, tryptamine and urea, while that of tuberculosis patients--tryptophan metabolites, including 3-hydroxykynurenine, known as carcinogen. Administration of pyridoxine does not eliminate metabolic disturbances caused by anti-tuberculosis of preparations, while thiamine may inhibit pyridoxine enzymes, thus aggravating these disorders.
D002273:Carcinogens / Q000378:metabolism*; D004341:Drug Evaluation; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects* / Q000031:analogs & derivatives*; D011736:Pyridoxine / Q000008:administration & dosage; D013831:Thiamine / Q000008:administration & dosage; D013997:Time Factors; D014364:Tryptophan / Q000652:urine*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000652:urine
D002273:Carcinogens; D014364:Tryptophan; D011736:Pyridoxine; D007538:Isoniazid; D013831:Thiamine
Vydelenie s mochoĭ blastomogennykh metabolitov triptofana u bol'nykh, lechennykh tubazidom i ftivazidom.