Behavioral supersensitivity to methamphetamine following chronic treatment with (--)-sulpiride in the rat.
Hyperactivity induced by methamphetamine (4 mg/kg i.p.) was actographically evaluated in rats chronically treated with sulpiride stereoisomers and haloperidol. The trial was repeated with half dose of the stimulant after 8 days of neuroleptic withdrawal. (--)-Sulpiride and haloperidol antagonized the response to the full dose of methamphetamine and induced behavioral supersensitivity to the challenging dose. (+)-Sulpiride strongly enhanced the effect of 4 mg/kg of methamphetamine, but no relevant changes in dopaminergic sensitivity followed.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D013375:Substance Withdrawal Syndrome; D013469:Sulpiride / Q000494:pharmacology*
D008694:Methamphetamine; D013469:Sulpiride; D006220:Haloperidol