The effect of administration of a single dose of T-2 toxin on blood coagulation in the rabbit.
The single intravenous administration of T-2 toxin to rabbits at a dosage of 0.5 mg per kg body weight produced an alteration in several blood coagulation parameters. The activities of factors VII, VIII, IX, X and XI were decreased by approximately 40% six hours after T-2 toxin administration. Plasma fibrinogen concentration became elevated within 24 hours after T-2 toxin exposure. Circulating platelet numbers were unaffected by T-2 toxin administration. The similarity of coagulation parameter changes induced by T-2 toxin in animals receiving daily subcutaneous injections of vitamin K (0.5 mg per kg body weight) and those in nonvitamin K supplemented animals suggests that T-2 toxin does not function as a vitamin K antagonist.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000032:analysis; D001792:Blood Platelets / Q000166:cytology; D005260:Female; D007263:Infusions, Parenteral / Q000662:veterinary; D008297:Male; D010314:Partial Thromboplastin Time / Q000662:veterinary; D011517:Prothrombin Time / Q000662:veterinary; D011817:Rabbits / Q000097:blood*; D012717:Sesquiterpenes / Q000494:pharmacology*; D013605:T-2 Toxin / Q000008:administration & dosage / Q000494:pharmacology*; D014812:Vitamin K / Q000008:administration & dosage
D001779:Blood Coagulation Factors; D012717:Sesquiterpenes; D014812:Vitamin K; D013605:T-2 Toxin