title: Antiarrhythmic and hemodynamic responses to adenosine triphosphate during infusion of epinephrine in dogs anesthetized with halothane.
abstract: The effects of adenosine triphosphate (ATP) on cardiovascular responses to epinephrine were evaluated in dogs anesthetized with halothane. The dose of epinephrine required to induce arrhythmias averaged 1.05 +/- 0.52 microgram/kg/min. The dose of ATP required to abolish these arrhythmias averaged 1.64 +/- 0.67 mg/kg/min. ATP had not only an antiarrhythmic effect but also antagonized epinephrine-induced increases in heart rate, systemic vascular resistance, mean arterial blood pressure, and further increased cardiac index. ATP had, however, no significant effect on epinephrine-induced increases in myocardial contractility.
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000503:physiopathology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D004837:Epinephrine / Q000037:antagonists & inhibitors*; D005260:Female; D006221:Halothane; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male
chemical_list: D000889:Anti-Arrhythmia Agents; D000255:Adenosine Triphosphate; D006221:Halothane; D004837:Epinephrine