[Effect of psychotropic drugs on sleep disorders in rats during alcohol withdrawal].
The effects of sodium hydroxybutyrate (100 mg/kg); phenazepam (1 mg/kg), apomorphine (0.1 mg/kg and haloperidol (1 mg/kg) on the electrophysiological sleep pattern were studied in rats during 7-day alcohol withdrawal after its voluntary consumption for 13 months. It was shown that alcohol withdrawal led to profound disorders in the sleep-waking cycle. Sodium hydroxybutyrate prevented these disturbances and brought sleep to normal. Phenazepam exerted a powerful sedative and hypnotic effects but did not improve the balance of sleep phases. Apomorphine displayed a tendency to sleep normalization. However, this effect was short-term. Haloperidol did not eliminate abstinence manifestations in the sleep pattern.
D000437:Alcoholism / Q000150:complications / Q000628:therapy*; D000818:Animals; D014151:Anti-Anxiety Agents; D001058:Apomorphine / Q000627:therapeutic use; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000627:therapeutic use; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D051381:Rats; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000209:etiology; D012978:Sodium Oxybate / Q000627:therapeutic use; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D011619:Psychotropic Drugs; D001569:Benzodiazepines; C017928:phenazepam; D012978:Sodium Oxybate; D006220:Haloperidol; D001058:Apomorphine
Vliianie psikotropnykh veschestv na narusheniia sna v period lisheniia alkogolia u krys.