Studies of the interaction of mitochondrial creatine kinase with the mitochondrial membrane.
In this study we have investigated the binding characteristics of creatine kinase (CK) with mitochondrial membrane. Creatine kinase was found to bind membranes by electrostatic forces. At physiological pH, the interaction seems to be between positively charged groups on the enzyme protein and negatively charged groups on the membrane.
D000818:Animals; D001665:Binding Sites; D002417:Cattle; D003402:Creatine Kinase / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007425:Intracellular Membranes / Q000201:enzymology*; D008081:Liposomes / Q000378:metabolism; D008929:Mitochondria, Heart / Q000201:enzymology*
D008081:Liposomes; D003402:Creatine Kinase