Effects of naloxone on ethanol and acetaldehyde-induced electroencephalographic changes in rabbits.
Rabbits treated with a single IV dose of ethanol, 0.6 g/kg, exhibited rapid EEG synchronization and behavioral changes that were reversed and, in part, prevented by the opiate antagonist, naloxone, 40 micrograms/kg. The continuous intracerebroventricular infusion of acetaldehyde, 10 or 120 micrograms/min. caused biphasic changes with EEG activation and severe bradycardia followed by overt synchrony during the post-infusion period. The results of the present study provide further evidence for the ability of naloxone to counteract some acute effects of ethanol. Moreover, they do not support a role of acetaldehyde itself as mediator of EEG changes associated with mild alcohol intoxication.
D000079:Acetaldehyde / Q000494:pharmacology*; D000818:Animals; D001143:Arousal / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects*; D003344:Cortical Synchronization; D003864:Depression, Chemical; D004569:Electroencephalography; D000431:Ethanol / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009129:Muscle Tonus / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology*; D011817:Rabbits
D009270:Naloxone; D000431:Ethanol; D000079:Acetaldehyde