Familial Williams syndrome.
Characteristic features of the Williams syndrome were observed in a mother and her presumably dizygotic twin daughters, suggesting either an X-linked dominant, autosomal dominant or multifactorial inheritance in this pedigree. The Williams syndrome generally has been thought to have a sporadic occurrence. The rare familial occurrence, however, suggests a possible heterogeneity in its etiology and also points out the importance of careful examination of the other family members for proper genetic counseling.
D000015:Abnormalities, Multiple / Q000235:genetics*; D000328:Adult; D001024:Aortic Valve Stenosis / Q000151:congenital / Q000235:genetics; D002648:Child; D004200:Diseases in Twins; D005260:Female; D006130:Growth Disorders / Q000235:genetics; D006330:Heart Defects, Congenital / Q000235:genetics*; D006801:Humans; D010375:Pedigree; D011247:Pregnancy; D013577:Syndrome; D014429:Twins, Dizygotic