Synthesis and hypotensive activity of some analogs of the C-terminal hexapeptideamide of eledoisin.
The C-terminal (6-11)-hexapeptideamide Ala-Phe-Ile-Gly-Leu-Met-NH2 of eledoisin was synthesized by the solid phase method according to Merrifield. The alpha-amino group of alanine was acylated with heterocyclic or aromatic residues. These new compounds showed dose dependent hypotensive activities in the rabbit.
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D001794:Blood Pressure / Q000187:drug effects; D004600:Eledoisin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000494:pharmacology; D011817:Rabbits; D013997:Time Factors
D000959:Antihypertensive Agents; D010446:Peptide Fragments; D004600:Eledoisin