[Use of heterologous antireceptor antibodies for specific reversal of acute homologous disease in mice].
Antireceptor antibodies anti- (CBA-anti-C57BL/6) and anti-(C57BL/6-anti-BALB/c) were obtained in a heterologous system by immunization of rabbits with alloimmune mouse lymphocytes and intensive absorption of immune rabbit sera. In the complement-dependent cytotoxic assay, these antireceptor antibodies were able to lyse only T-lymphoblasts with corresponding idiotypic specificity but not T-lymphoblasts of other idiotypes and normal T- and B- lymphocytes of various strains. It was also shown that antireceptor antibodies specifically inhibit the lethal graft-versus-host disease after injection of allogenic parental spleen cells into irradiated F1-recipients. These results suggest that heterologous antireceptor antibodies are capable of inhibiting specifically the immune responses to allogenic transplantation antigens.
D000818:Animals; D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006086:Graft vs Host Disease / Q000628:therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011817:Rabbits / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*
D000961:Antilymphocyte Serum; D011948:Receptors, Antigen, T-Cell
Ispol'zovanie geterologichnykh antiretseptornykh antitel dlia spetsificheskoĭ otmeny ostroĭ gomologichnoĭ bolezni u myshĕi.