[Interaction of coronary-active compounds and anti-inflammatory drugs on the coronary vascular system (author's transl)].
The effect of acemetacin (Rantudil) and indomethacin, respectively, on coronary flow and O2-pressure in coronary sinus blood before and after i.v. injections of coronary active compounds was permanently registered in anesthetised closed-chest dogs. It was found that i.v. infections of 2 mg acemetacin/kg extended effects of i.v. injected morocromen. After administration of morocromen (4.0 mg/kg), carbocromen (2.0 mg/kg), or dipyridamole (0.4 mg/kg) the application of acemetacin or indomethacin, respectively, produced a markedly increased effect on the coronary blood vessels. Comparative studies of indole-derivatives, the Ca-antagonizing compounds prenylamine, verapamil, nifedipine, and the phosphodiesterase inhibitor papaverine showed no similar effects.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002317:Cardiovascular Agents / Q000494:pharmacology*; D002866:Chromonar / Q000494:pharmacology; D003326:Coronary Circulation / Q000187:drug effects*; D003374:Coumarins / Q000494:pharmacology; D004176:Dipyridamole / Q000494:pharmacology; D004285:Dogs; D004347:Drug Interactions; D005260:Female; D007210:Indoleacetic Acids / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology / Q000031:analogs & derivatives; D008297:Male; D009025:Morpholines / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D002317:Cardiovascular Agents; D003374:Coumarins; D007210:Indoleacetic Acids; D009025:Morpholines; C026784:acemetacin; D004176:Dipyridamole; C012447:morocromen; D002866:Chromonar; D007213:Indomethacin
Wechselwirkungen koronarwirksamer Substanzen und Entzündungshemmer auf das Koronargefässsystem.