Neurotropic melanoma of the vulva.
A spindle cell melanoma of the clitoris was associated with a large area of lentiginous melanocytic dysplasia in the vulva of a 51-year-old woman. There was extensive neoplastic of the dermis, a desmoplastic reaction, and replacement of perineurial and Schwann cells by tumor cells (neurotropism). The superficial dysplastic components were pigmented, but melanosomes were not identified in a lymph node metastasis. Here the internuclear areas strongly resembled neuropil. Vulvar melanoma is rate, and this is the first report of neurotropic melanoma in this site.
D002467:Cell Nucleus / Q000648:ultrastructure; D002987:Clitoris / Q000601:surgery; D003599:Cytoskeleton / Q000648:ultrastructure; D004817:Epidermis / Q000473:pathology; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008544:Melanocytes / Q000473:pathology; D008545:Melanoma / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure