title: 7 alpha- and 7 beta-carboxymethyl-derivatives of 17-hydroxyprogesterone and 11-deoxycortisol. Synthesis and immunogenic properties.
abstract: 7 alpha- and 7 beta-carboxymethyl-derivatives of 17-hydroxyprogesterone and 11-deoxycortisol have been synthesized. After coupling to bovine serum albumin, they were used to elicit antibodies in rabbits. No major difference in the steroid specificity of the antisera was observed when either 7 alpha- or 7 beta-epimers were used for immunization. In both cases, highly specific antisera were obtained which may possibly be used to assay human plasma 17-hydroxyprogesterone and 11-deoxycortisol without chromatographic purification.
mesh_terms: D015065:17-Hydroxycorticosteroids / Q000138:chemical synthesis*; D000818:Animals; D003350:Cortodoxone / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000276:immunology; D006908:Hydroxyprogesterones / Q000138:chemical synthesis* / Q000276:immunology; D007106:Immune Sera; D011817:Rabbits / Q000276:immunology; D013329:Structure-Activity Relationship
chemical_list: D015065:17-Hydroxycorticosteroids; C024954:7 alpha-carboxymethyl-11-deoxycortisol; C024955:7 alpha-carboxymethyl-17-hydroxyprogesterone; C024953:7 beta-carboxymethyl-11-deoxycortisol; C024956:7 beta-carboxymethyl-17-hydroxyprogesterone; D006908:Hydroxyprogesterones; D007106:Immune Sera; D003350:Cortodoxone