Comparison of three different assays for the assessment of ciguatoxin in fish tissues: radioimmunoassay, mouse bioassay and in vitro guinea pig atrium assay.
Moderate correlation was shown between the following tests: RIA: mouse bioassay (r = 0.58); RIA: guinea pig atrium assay (r = 0.62); guinea pig atrium assay: mouse bioassay (r = 0.62). All three assay procedures showed good correlation when ciguatoxin was present in tissues in high concentrations. The results also suggest that more than one structurally related toxin may be present in the fish tissues.
D000818:Animals; D001681:Biological Assay / Q000379:methods*; D002922:Ciguatoxins / Q000032:analysis* / Q000633:toxicity; D005399:Fishes / Q000378:metabolism*; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects; D066298:In Vitro Techniques; D008387:Marine Toxins / Q000032:analysis*; D051379:Mice; D011863:Radioimmunoassay
D008387:Marine Toxins; D002922:Ciguatoxins