Studies on a human melanoma x hamster hybrid line selected by metastasis.
A highly metastatic hybrid line of human melanoma and tumorigenic, poorly metastatic hamster cells (BHK-21) was selected by pulmonary metastasis after injection of a fusion mixture into a Syrian hamster. The in vivo growth properties, karyotype, and plasminogen activator production of the line are reported. Monoclonal antibodies against the line indicated that it was expressing at least 8 human antigens although no melanoma-specific antigens were detected.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000951:Antigens, Neoplasm / Q000032:analysis; D002273:Carcinogens; D002460:Cell Line; D006224:Cricetinae; D006801:Humans; D006822:Hybrid Cells; D007621:Karyotyping; D007668:Kidney; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008545:Melanoma / Q000235:genetics*; D008647:Mesocricetus; D009362:Neoplasm Metastasis / Q000235:genetics*; D010960:Plasminogen Activators / Q000032:analysis
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D002273:Carcinogens; D010960:Plasminogen Activators