[A new class of highly active progestagens: 17 alpha-CH2X-substituted gona-4,9(10)-dienes. 58. Steroids].
The synthesis of new gona-4,9(10)-dienes with a 17 alpha-CH2X-substituent (X = CN, N3, Cl or Br) is described. The progestagenic activity of these substances was studied in the McPhail assay using immature rabbits. The compound XVI (X = CN, STS 557) is the most potent one, showing an activity about ten times higher than D-norgestrel. Differences in the activity caused by different routes of application are discussed.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006067:Gonanes / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D009644:Norgestrel / Q000494:pharmacology; D045167:Progesterone Congeners / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D011817:Rabbits; D014590:Uterine Contraction / Q000187:drug effects
D006067:Gonanes; D045167:Progesterone Congeners; D009644:Norgestrel
Eine neue Klasse hochwirksamer Progestagene: 17 alpha-CH2X-substituierte Gona-4,9(10)-diene. 58. Mitteilung: Steroide.