title: Morphology of transplacentally induced nervous system tumors in rats: some aspects of this model in neurooncology.
abstract: The morphology of 1136 single tumors of the nervous system induced by transplacental action of alkylating and related substances is analyzed. Tumors of the central nervous system are considered to yield the most representative model for the different stages of gliomas in humans. This and derived standardized models therefore are appropriate for studying open questions, especially as regards the treatment of human brain tumors.
mesh_terms: D000477:Alkylating Agents; D000818:Animals; D002460:Cell Line; D005260:Female; D005333:Fetus / Q000187:drug effects; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000151:congenital / Q000473:pathology; D009423:Nervous System Neoplasms / Q000139:chemically induced / Q000151:congenital* / Q000473:pathology; D011247:Pregnancy; D051381:Rats
chemical_list: D000477:Alkylating Agents