[Nitroxyl derivatives of rubomycin].
The toxic and antitumor effects of new analogs of rubomycin were studied. It was shown that the spin-labeled derivatives had the lowest toxicity and highest antitumor activity. The diamagnetic analog was similar to rubomycin in its antitumor effect. It was demonstrated that ruboxyl-l had a lower cardiotoxicity than rubomycin and did not inhibit hemopoiesis at the maximum tolerated doses.
D000818:Animals; D003497:Cyclic N-Oxides / Q000633:toxicity*; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D007700:Kinetics; D007928:Lethal Dose 50; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice; D009368:Neoplasm Transplantation; D013113:Spin Labels; D013997:Time Factors
D003497:Cyclic N-Oxides; D013113:Spin Labels; D003630:Daunorubicin
Nitroksil'nye proizvodnye rubomitsina.