Post-transfusion purpura as a gynecologic complication.
Post-transfusion purpura (PTP) is a recently separated category of thrombocytopenic purpura occurring mainly in women. It is an acute, severe thrombocytopenic state with clinical manifestations of hemorrhage that may be fatal. It usually occurs 5 to 8 days after transfusion, usually after administration of whole blood. The typical patient is a middle-aged, multiparous white woman who has received a transfusion and has undergone an operation, often a gynecologic procedure. Diagnosis may be suspected by normal clotting studies, bone marrow biopsy showing increased megakaryocytes, and demonstration of a potent antibody reactive against platelets by clot-retraction inhibition, complement fixation, or 51Cr-release studies. The treatment of choice is exchange transfusion or plasmapheresis, unless these procedures are medically contraindicated. Because of the lack of reports in the gynecology literature on PTP, a case report and discussion are presented.
D001706:Biopsy; D001780:Blood Coagulation Tests; D001853:Bone Marrow / Q000473:pathology; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D005831:Genital Diseases, Female / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D010956:Plasmapheresis; D011696:Purpura, Thrombocytopenic / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D065227:Transfusion Reaction