[Possibility of the use of perfluorochemicals (fluorocarbons) as adjuvants in chemotherapy of cancer].
In Fischer 344 rats weighing about 100 gr., 7 X 10(5) 9L tumor cells were implanted into right cerebral hemisphere. BCNU. Fluosol-43 (perfluorochemicals blood substitute), or combined therapy BCNU and Fluosol-43 were initiated on Day 7 postimplantation and its therapeutic effect was studied. Mean survival time of control animals was 15.23 +/- 2.84 (SD) days, the group of Fluosol-43 treated in oxygen chamber (95% Oxygen & 5% Carbon Dioxide) was 15.30 +/- 2.11 (SD) days. BCNU treatment alone prolonged the mean survival time to 20.90 +/- 3.80 (SD) days, BCNU plus Fluosol-43 in normal aeration was 21.20 +/- 2.63 (SD) days. On the other hand, BCNU plus Fluosol-43 in oxygen chamber showed a significant increase of mean survival time of 32.27 +/- 4.80 (SD) days (p less than 0.005). From these results, it was concluded that Fluosol-43 (perfluorochemicals) with oxygen might have a synergistic effect for BCNU chemotherapy.
D000818:Animals; D001802:Blood Substitutes / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000098:blood supply / Q000188:drug therapy*; D002330:Carmustine / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005466:Fluorocarbons / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000188:drug therapy; D051381:Rats; D011916:Rats, Inbred F344
D001802:Blood Substitutes; D005466:Fluorocarbons; C008807:perfluorotributylamine; D002330:Carmustine