Human lymphocyte affinity for sheep erythrocytes in young and aged healthy subjects.
The kinetics of sheep erythrocyte rosette formation by human peripheral blood lymphocytes from young-adult and aged individuals were studied in 20 paired experiments. No difference in the rate and saturation plateau of formation could be found despite a slight increase in early rosette-forming cells. We conclude that the membrane affinity for sheep erythrocytes is unaffected by ageing and that the proportion of the circulating early E-RFC subpopulation is increased in healthy older subjects.
D000328:Adult; D000368:Aged; D000375:Aging; D000818:Animals; D002462:Cell Membrane / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D012397:Rosette Formation; D012756:Sheep / Q000276:immunology; D013997:Time Factors