X chromatin and chromosome examination in aged women.
X chromatin frequencies were compared between aged, middle-aged and young women and statistically significant decrease in frequency was found in the aged as compared to the middle-aged and the young women. For a subsample of aged women results of chromosome examinations were also available which allowed comparison of the frequencies of X chromatin and monosomy C; no significant correlation emerged. This latter finding indicates that karyotypic analysis is necessary for the determination of monosomy C; and that X chromatin counts from buccal mucosal cells cannot be substituted for the examination of karyotypes.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000453:epidemiology; D025063:Chromosome Disorders; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D011247:Pregnancy; D012728:Sex Chromatin / Q000032:analysis*; D012730:Sex Chromosomes / Q000032:analysis*; D014427:Twins; D014960:X Chromosome / Q000032:analysis*