Demonstration of influenza virus reproduction stages sensitive to remantadine.
The antiviral action of remantadine was studied in bovine embryo kidney cells infected with influenza virus A/Victoria 35/72(H3N2-3). The drug was administered at different stages of influenza virus reproduction. Remantadine at a concentration of 50 micrograms/ml did not inhibit the activities of nuclear DNA-dependent RNA polymerase and of virion and virus-induced polymerases. Remantadine was found to inhibit the synthesis of influenza virus RNA at the stages of transcription and replication.
D000218:Adamantane / Q000031:analogs & derivatives*; D000818:Animals; D002417:Cattle; D002467:Cell Nucleus / Q000201:enzymology; D012321:DNA-Directed RNA Polymerases / Q000096:biosynthesis; D004622:Embryo, Mammalian; D005814:Genes, Viral / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D009980:Influenza A virus / Q000187:drug effects*; D007668:Kidney; D012367:RNA, Viral / Q000096:biosynthesis; D012299:Rimantadine / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects; D014776:Virus Cultivation; D014779:Virus Replication
D012367:RNA, Viral; D012299:Rimantadine; D012321:DNA-Directed RNA Polymerases; D000218:Adamantane