title: Electrophysiological evidence for multiple sites of actions of angiotensin II for stimulating paraventricular neurosecretory cells in the rat.
abstract: Microelectrophoretically (MEPh) applied angiotensin II (AII) excited about half of the PV neurosecretory cells recorded. The excitation was blocked by MEPh applied Sar1-Ala8-AII. Intraventricular (IVT) injection of AII excited both the sensitive cells and insensitive cells to the MEPh applied AII. MEPh-applied Sar1-Ala8-AII, however, blocked the IVT AII induced excitation only in the former type of the cells.
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D004553:Electric Conductivity; D004971:Estrus; D005260:Female; D007031:Hypothalamus / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000502:physiology*; D011247:Pregnancy; D011359:Proestrus; D051381:Rats
chemical_list: D000804:Angiotensin II