Antacid aspiration in rabbits: a comparison of Mylanta and Bicitra.
The effects of aspiration of (a) 2 ml of Mylanta (a particulate antacid) mixed with 2 ml of hydrochloric acid (pH 1.5), (b) 2 ml of half-strength Bicitra (a soluble antacid) mixed with 2 ml of hydrochloric acid (pH 1.5), (c) 4 ml of hydrochloric acid (pH 1.5), and (d) 4 ml of normal saline (pH 6.5) on arterial blood gas tensions and lung pathology were compared in anesthetized rabbits. PaO2 decreased similarly in all animals 15 minutes after aspiration, but recovered to normal levels 4 hours after aspiration of saline and 48 hours after aspiration of Bicitra. PaO2 remained depressed after aspiration of Mylanta and HCl. Gross and microscopic evidence of lung injury was most severe in animals that aspirated Mylanta. One animal died 8 hours after aspiration of Mylanta.
D000536:Aluminum Hydroxide / Q000009:adverse effects*; D000818:Animals; D000863:Antacids / Q000009:adverse effects*; D002951:Citrates / Q000009:adverse effects*; D019343:Citric Acid; D004338:Drug Combinations / Q000009:adverse effects; D008274:Magnesium / Q000009:adverse effects*; D008276:Magnesium Hydroxide / Q000009:adverse effects*; D008297:Male; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011015:Pneumonia, Aspiration / Q000139:chemically induced* / Q000473:pathology; D011183:Postoperative Complications / Q000139:chemically induced; D011300:Preoperative Care; D011817:Rabbits; D012828:Silicones / Q000009:adverse effects*; D012841:Simethicone / Q000009:adverse effects*
D000863:Antacids; D002951:Citrates; D004338:Drug Combinations; D012828:Silicones; C008570:aluminum hydroxide, magnesium hydroxide, simethicone drug combination; D019343:Citric Acid; D000536:Aluminum Hydroxide; D012841:Simethicone; D008274:Magnesium; D008276:Magnesium Hydroxide; D010100:Oxygen