title: Immunotherapy with grass pollen major allergens. Immunological results from a prospective 3-year double blind study.
abstract: Preseasonal hyposensitization stimulated an intercorrelated increase in both serum-specific IgE and allergen-specific IgG. Subsequent perennial treatment depressed the stimulated IgE response and the basophil cell sensitivity, whereas the allergen-specific IgG response showed further increase and persisted at a high level. Nasal IgE response was stimulated from the second pollen season and subsequently became depressed. One year after the end of hyposensitization the allergen-specific IgG response had fallen by 25-50%.
mesh_terms: D000485:Allergens / Q000008:administration & dosage* / Q000592:standards; D000918:Antibody Specificity; D001491:Basophils / Q000276:immunology; D003888:Desensitization, Immunologic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D008297:Male; D009297:Nasal Mucosa / Q000276:immunology; D011058:Pollen / Q000276:immunology*; D011446:Prospective Studies; D012015:Reference Standards; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000628:therapy*
chemical_list: D000485:Allergens; D007074:Immunoglobulin G; D007073:Immunoglobulin E