Failure of chlorpromazine to inhibit fluid accumulation caused by Escherichia coli heat-stable enterotoxin in suckling mice.
We studied the effect of chlorpromazine on fluid accumulation caused by purified heat-stable enterotoxin (ST) from enterotoxigenic Escherichia coli in suckling mice. We found that chlorpromazine inactivated ST itself in vitro, but did not inhibit the activity of ST in the intestines.
D000818:Animals; D000833:Animals, Suckling; D001427:Bacterial Toxins; D001826:Body Fluids / Q000378:metabolism*; D002746:Chlorpromazine / Q000008:administration & dosage / Q000494:pharmacology*; D004768:Enterotoxins / Q000494:pharmacology*; D029968:Escherichia coli Proteins; D007413:Intestinal Mucosa / Q000378:metabolism*; D051379:Mice; D010529:Peritoneal Cavity
D001427:Bacterial Toxins; D004768:Enterotoxins; D029968:Escherichia coli Proteins; C034151:heat stable toxin (E coli); D002746:Chlorpromazine