Tolfenamic acid. Detection and structure of urinary metabolites.
N-(2-Methyl-3-chlorophenyl)anthranilic acid (tolfenamic acid) and its metabolites in serum and urine were analyzed by a reversed-phase ion-pair HPLC method. The major metabolites were N-(2-methyl-3-chloro-4-hydroxyphenyl)anthranilic acid, and one of the minor metabolites was N-(2-formyl-3-chlorophenyl)anthranilic acid, i.e., products resulting from hydroxylation in either the methyl group or the methylchlorophenyl group of tolfenamic acid, and further oxidation of the hydroxymethyl group to a formyl group.
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000378:metabolism*; D001711:Biotransformation; D005260:Female; D005439:Flufenamic Acid / Q000378:metabolism; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D008297:Male; D008528:Mefenamic Acid / Q000378:metabolism; D010084:Oxidation-Reduction; D013997:Time Factors; D062367:ortho-Aminobenzoates / Q000378:metabolism*
D000893:Anti-Inflammatory Agents; D062367:ortho-Aminobenzoates; D008528:Mefenamic Acid; C009500:tolfenamic acid; D005439:Flufenamic Acid; D005966:Glucuronidase