Age associated decrease of N-acetyl-beta-glucosaminidase activity in the lens epithelial cells from C57Bl/6 mice.
Lens epithelial cells were isolated from samples of C57BL/6 and CD-1 mice at different ages between 1 and 5 months, and assayed for the level of N-acetyl-beta-glucosaminidase and their ability to replicate in-vitro. The lens epithelial cells from C57BL/6 mice had a reduced replicative potential compared to other normal strains. A statistically significant decrease in active enzyme levels was demonstrated to be associated with increased animal age of C57BL/6 mice.
D000118:Acetylglucosaminidase / Q000378:metabolism*; D000375:Aging; D000818:Animals; D004847:Epithelial Cells; D005260:Female; D006596:Hexosaminidases / Q000378:metabolism*; D007908:Lens, Crystalline / Q000201:enzymology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA
D006596:Hexosaminidases; D000118:Acetylglucosaminidase