Hydroxylation of benzo[a]pyrene and binding of (-)trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene metabolites to deoxyribonucleic acid catalyzed by purified forms of rabbit liver microsomal cytochrome P-450. Effect of 7,8-benzoflavone, butylated hydroxytoluene and ascorbic acid.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001571:Benzoflavones / Q000494:pharmacology; D001580:Benzopyrenes / Q000378:metabolism*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D004101:Dihydroxydihydrobenzopyrenes; D006900:Hydroxylation; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D008862:Microsomes, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D011817:Rabbits
D001571:Benzoflavones; D001580:Benzopyrenes; D004101:Dihydroxydihydrobenzopyrenes; C017228:benzo(a)pyrene 7,8-dihydrodiol; D002084:Butylated Hydroxytoluene; D008748:Methylcholanthrene; C011512:alpha-naphthoflavone; D004247:DNA; D003577:Cytochrome P-450 Enzyme System; D001205:Ascorbic Acid