[Reaction of intercellular contacts of the intestinal epithelium to a non-specific stress].
The influence of a short-term ischemia on the small intestinal epithelial cell contacts was studied in the rat. The cell contact condition was evaluated by the parameters of the paracellular ionic permeability and the cell adhesion. A severe diminution of the adhesion is noted immediately after the ischemia and during the next 4-8 h, after what it is replaced by an increase above the control values while the mitotic index is reduced. On the 4th day an increase of the mitotic index is accompanied by a new reduction of the cell adhesion. The fluctuation of the cell adhesion is always accompanied by a fall of the transepithelial resistance and a modification of the relative ionic permeability PNa/PCl. These and other data may be a sign of deep and long alterations in the enterocyte plasmic membranes as an answer to the ischemic trauma, as well as a proof of the influence of the cell contact state on the cellular turn-over.
D000818:Animals; D002448:Cell Adhesion; D002463:Cell Membrane Permeability; D004848:Epithelium / Q000473:pathology; D007421:Intestine, Small / Q000098:blood supply* / Q000473:pathology; D007511:Ischemia / Q000473:pathology*; D008297:Male; D008564:Membrane Potentials; D008940:Mitotic Index; D051381:Rats
La réaction des contacts intercellulaires de l'épithélium intestinal à une agression non spécifique.