The effect of budipine on the central serotoninergic system.
Budipine, a new potential antiparkinsonian drug, did not affect or--in higher doses--inhibited the flexor reflex in spinal rats, having no influence on LSD- or fenfluramine-induced flexor-reflex stimulation. It did not affect the body temperature either of the rat kept at a high ambient temperature or of the rabbit in a normothermic surroundings. It weakened fenfluramine hyperthermia in heat-adapted rats, but not in rabbits. Only in high doses budipine weakened tryptamine-induced clonic convulsions of rat forepaws. Budipine partially prevented fenfluramine-induced depletion of whole brain 5-hydroxytryptamine. The above results show that budipine demonstrates some properties of 5-HT uptake inhibitors.
D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D005277:Fenfluramine / Q000494:pharmacology; D006614:Hindlimb / Q000502:physiology; D008297:Male; D010880:Piperidines / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced; D012701:Serotonin / Q000378:metabolism / Q000502:physiology*; D014363:Tryptamines / Q000494:pharmacology
D000978:Antiparkinson Agents; D010880:Piperidines; D014363:Tryptamines; D005277:Fenfluramine; D012701:Serotonin; C026710:budipine