title: Central nervous system activity of 7-substituted 1-azaphenoxathiin analogues and their oxidation products.
abstract: A number of 7-substituted 1-azaphenoxathiins and their sulfone oxidation products have been synthesized and screened for central nervous system activity. Some of the compounds have antidepressant activity, with the most active, 7-(trifluoromethyl)-1-azaphenoxathiin 10,10-dioxide (8), having similar potency to imipramine.
mesh_terms: D000374:Aggression / Q000187:drug effects; D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D001522:Behavior, Animal / Q000187:drug effects; D001763:Blepharoptosis / Q000503:physiopathology; D002492:Central Nervous System Depressants / Q000138:chemical synthesis*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000037:antagonists & inhibitors; D051379:Mice; D010075:Oxathiins / Q000138:chemical synthesis* / Q000494:pharmacology; D010084:Oxidation-Reduction; D051381:Rats; D013747:Tetrabenazine / Q000037:antagonists & inhibitors
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D002492:Central Nervous System Depressants; D006571:Heterocyclic Compounds; D010075:Oxathiins; D008694:Methamphetamine; C024532:1-azaphenoxathiin; D013747:Tetrabenazine