title: Right-sided population bias and lateralization of activity in normal rats.
abstract: Of 602 rats tested for amphetamine-induced or nocturnal rotation (circling behavior), 54.8% (P less than 0.025) had right side biases. Of 292 rats tested in two-lever operant situations, 57.5% (P less than 0.02) preferred the right lever. Right-biased rats were significantly more active and had stronger side preferences than left-biased rats. It is suggested that the increase in right-sided population bias in humans, as compared to rodents, is related to a cortical asymmetry and the phylogenetic increase in cortical modulation of subcortical structures.
mesh_terms: D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000502:physiology; D006801:Humans; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects
chemical_list: D003913:Dextroamphetamine