title: The stability of adrenaline ophthalmic solutions on sterilization and storage.
abstract: The stability of adrenaline ophthalmic solutions, at pH 5.8 and 7.4, to sterilization and storage conditions has been studied. Solutions sterilized by filtration or heating at 98 degrees C for 30 min showed no detectable degradation at either pH value, whilst sterilization at higher temperatures resulted in losses of up to 30%. Total degradation increased with increasing sterilization temperature at both pH values.
mesh_terms: D004355:Drug Stability; D004356:Drug Storage; D004837:Epinephrine; D006863:Hydrogen-Ion Concentration; D009883:Ophthalmic Solutions; D013242:Sterilization; D013696:Temperature
chemical_list: D009883:Ophthalmic Solutions; D004837:Epinephrine