Combined paraquat and acetaminophen toxicity.
A case of combined paraquat and acetaminophen ingestion is reported with accompanying serial serum levels (including pre- and postcharcoal hemoperfusion) and autopsy tissue levels of both toxins. An increased lethality (time until death) is suggested in rats receiving both toxins as compared to either toxin alone. A proposed mechanism for the combined toxicity of the two drugs is hypothesized.
D000082:Acetaminophen / Q000032:analysis / Q000506:poisoning*; D000328:Adult; D000818:Animals; D004357:Drug Synergism; D006801:Humans; D008297:Male; D010269:Paraquat / Q000032:analysis / Q000506:poisoning*; D051381:Rats; D011919:Rats, Inbred Strains; D014020:Tissue Extracts / Q000032:analysis
D014020:Tissue Extracts; D000082:Acetaminophen; D010269:Paraquat