Effect of efferent denervation of the vagus nerve on nonadrenergic inhibitory responses obtained from the rat stomach in vitro.
The possibility that antidromic stimulation of afferent nerves is involved in the mediation of nonadrenergic inhibitory (NAI) responses obtained from isolated preparations was tested using the isolated rat stomach--vagus nerve preparation. Unilateral supranodose vagotomies 7-21 days prior to obtaining the preparations permitted efferent denervation to occur and the responses obtained in vitro from stimulation of the sectioned nerves were compared with those from the control nerves. Supranodose vagotomy abolished the responses obtained from the preparations while stimulation of the control nerves gave rise to normal biphasic responses consisting of both excitatory and NAI components. Histological examination of the nodose ganglia revealed the presence of normal sensory ganglion cells while abundant intact axons were observed in nerve trunks on the lesioned side. It is concluded that afferent nerves in the vagus are not involved in the mediation of NAI responses obtained from the rat stomach in vitro.
D000818:Animals; D003714:Denervation; D004525:Efferent Pathways / Q000502:physiology; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008297:Male; D009130:Muscle, Smooth / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000294:innervation* / Q000502:physiology; D014630:Vagus Nerve / Q000502:physiology*