Mutagenicity studies on fenticonazole, a new antifungal imidazole derivative.
The forward mutational assay on Schizosaccharomyces pombe and the mitotic gene conversion assay on Saccharomyces cerevisiae were performed in order to verify whether alpha-(2,4-dichlorophenyl)-beta,N-imidazolylethyl 4-phenylthiobenzyl ether nitrate (fenticonazole, Rec 15/1476) shows a potential mutagenicity. In both tests the drug does not seem to possess any mutagenic activity when compared with mutagenic standards.
D000818:Animals; D007093:Imidazoles / Q000633:toxicity*; D008862:Microsomes, Liver / Q000378:metabolism; D008938:Mitosis; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats; D012440:Saccharomyces / Q000235:genetics*
D007093:Imidazoles; D009153:Mutagens; C033486:fenticonazole