Pressure-volume and airway closure relationships in each lung in anaesthetized man.
Airway closure, functional residual capacity (FRC) and transpulmonary pressure-volume curves were assessed for each lung separately in the anaesthetized subject by means of a double lumen tracheal catheter. In the supine position airway closure occurred synchronously in the two lungs and 0.2-0.31 above FRC. The pressure- volume curves in both lungs were rather similar and critical closing pressure (CP) was approximately 3 cmH2O in each lung. In the left lateral posture, FRC was increased in the non-dependent and reduced in the dependent lung, while closing capacity (CC) remained unaltered. Airway closure was asynchronous and discontinuous between the two lungs. This was caused by the non-linear transpulmonary pressure-volume curve in the lungs, in conjunction with the vertical pleural pressure gradient. An interpulmonary "pendelluft" phenomenon was observed in the left lateral posture, increasing inhomogeneity of ventilation. It may depend on regional differences in compliance.
D000328:Adult; D000368:Aged; D000403:Airway Resistance; D000758:Anesthesia; D005260:Female; D005540:Forced Expiratory Flow Rates; D005652:Functional Residual Capacity; D006801:Humans; D007442:Intubation, Intratracheal; D008168:Lung / Q000502:physiology*; D008170:Lung Compliance; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010994:Pleura / Q000502:physiology; D011187:Posture; D011312:Pressure; D012119:Respiration; D013874:Thiopental / Q000008:administration & dosage
D013874:Thiopental