title: Epinephrine-induced arrhythmias during halothane anesthesia with the addition of nitrous oxide, nitrogen, or helium in dogs.
abstract: The arrhythmogenicity of epinephrine was examined in 34 male mongrel dogs awake and during 1.1 MAC steady state halothane-O2 anesthesia with the addition of 50% N2O, nitrogen, or helium. All anesthetized dogs required more epinephrine than did awake dogs to produce ventricular extrasystoles. Dogs given halothane-N2O were more sensitive to the epinephrine infusion than those given halothane-nitrogen or halothane-helium. The dogs given halothane-N2O also showed a small, but statistically significant difference from dogs given halothane-O2. These results suggest that the addition of N2O to halothane increases the cardiac arrhythmic potential of epinephrine in the dog.
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D004285:Dogs; D004338:Drug Combinations; D004837:Epinephrine / Q000633:toxicity*; D006221:Halothane / Q000633:toxicity*; D006371:Helium / Q000633:toxicity; D008297:Male; D009584:Nitrogen / Q000633:toxicity; D009609:Nitrous Oxide / Q000633:toxicity*; D010100:Oxygen
chemical_list: D004338:Drug Combinations; D006371:Helium; D009609:Nitrous Oxide; D009584:Nitrogen; D010100:Oxygen; D006221:Halothane; D004837:Epinephrine