Depletion in amygdaloid 5-hydroxytryptamine concentration and changes in social and aggressive behaviour.
5,7-Dihydroxytryptamine (10 and 20 microgram) was microinjected bilaterally into the amygdaloid complex of rats and resulted in 55% and 80% depletion in 5-hydroxytryptamine concentration, respectively. The lesioned animals exhibited fewer dominance behaviours and submitted more often to an intruder into their home-cages than did the vehicle-injected controls. The lesioned rats were also more submissive than were the controls when they were intruding into another rat's territory. Only the higher dose of toxin altered social investigatory behaviour when this was measured in an arena in which neither rat had established territory. The lesioned rats displayed less social interaction and had reduced levels of motor activity. The results are compared with those of other studies in which there has been regional or general depletion of brain 5-hydroxytryptamine concentration.
D015116:5,7-Dihydroxytryptamine; D000374:Aggression / Q000502:physiology*; D000378:Agonistic Behavior / Q000502:physiology*; D000679:Amygdala / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D006801:Humans; D008297:Male; D051381:Rats; D012701:Serotonin / Q000502:physiology*; D012919:Social Behavior
D015116:5,7-Dihydroxytryptamine; D012701:Serotonin