Acute effects of the coronary vasodilator carbocromen on myocardial oxygen consumption, substrate uptake and mechanical performance in intact dogs.
The effects of carbocromen on myocardial substrate uptake, myocardial oxygen consumption (MVO2), and the mechanical activity of the heart was studied in eight intact, anaesthetized dogs. Carbocromen was given i.v. as an injection of 2 mg/kg body weight, and measurements performed in the basal condition and during isoprenaline infusion. Carbocromen increased myocardial blood flow and reduced coronary vascular resistance 15 and 30 min after administration, whereas these values returned to normal after 60 min. The myocardial performance, net myocardial uptake of free fatty acids (FFA), glucose and lactate and MVO2 were not changed by carbocromen. A second isoprenaline infusion 90 min following carbocromen administration induced changes in myocardial performance, net substrate uptake and oxygen consumption not significantly different from isoprenaline infusion prior to carbocromen administration. The antianginal effects by carbocromen observed in clinical studies are more likely to be mediated through its known coronary vasodilator effect than any influence on myocardial metabolism.
D000818:Animals; D050260:Carbohydrate Metabolism; D002866:Chromonar / Q000494:pharmacology*; D003374:Coumarins / Q000494:pharmacology*; D004285:Dogs; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*
D003374:Coumarins; D005230:Fatty Acids, Nonesterified; D007545:Isoproterenol; D002866:Chromonar