Renal handling of cis-diamminedichloroplatinum(II).
The renal handling of cis-diamminedichloroplatinum(II) (cisplatin) was investigated by measuring the renal clearance of creatinine and free platinum (Pt). Free Pt clearance exceeded the glomerular filtration rate, indicating secretion of cisplatin or a metabolite. These results suggest that accumulation of Pt within renal tubular cells may be related to its nephrotoxicity.
D002945:Cisplatin / Q000378:metabolism* / Q000652:urine; D003404:Creatinine / Q000378:metabolism; D005260:Female; D005919:Glomerular Filtration Rate; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010984:Platinum / Q000097:blood / Q000652:urine; D013997:Time Factors
D010984:Platinum; D003404:Creatinine; D002945:Cisplatin