Lithium dosage regimen design by the repeated one-point method.
The applicability of the repeated one-point method for the design and adjustment of dosage regimen of lithium was studied in a crossover design experiment using the Beagle dog as a model. It was found that the steady-state concentrations reached after administration of the corresponding loading and maintenance doses were within the 95% confidence interval for the three previously selected levels of 0.6, 0.8 and 1.0 mEq/l. The good correlation observed between animal and published human data suggests that this model is a useful one for further pharmacokinetic studies on lithium.
D000818:Animals; D004285:Dogs; D004334:Drug Administration Schedule; D007700:Kinetics; D008094:Lithium / Q000008:administration & dosage* / Q000378:metabolism; D008297:Male; D008954:Models, Biological
D008094:Lithium