Plasma kinetics of digoxin in the cat.
The biological half-life of digoxin was 33.3 +/- 9.5 hours in 6 cats after a single IV injection. Longer half-lives were obtained after chronic oral administration, indicating that digoxin elimination is capacity-limited in the cat. The mean percentage of urinary excretion of digoxin after a single IV dose was 45% +/- 9.7% over a 10-day period. Toxic plasma concentrations ranged from 2.4 to 2.9 ng/ml, and 5 of 6 cats had clinical signs of toxicosis at concentrations greater than 2.6 ng/ml. Prolongation of the PQ interval was seen on the ECG at nontoxic plasma concentrations in 4 of 6 cats. The most striking ECG evidence of digoxin toxicosis was ST-segment elevation seen in 3 of the 6 cats.
D000284:Administration, Oral; D000818:Animals; D002371:Cat Diseases / Q000139:chemically induced / Q000503:physiopathology; D002415:Cats / Q000097:blood*; D004077:Digoxin / Q000008:administration & dosage / Q000097:blood*; D004562:Electrocardiography / Q000662:veterinary; D005260:Female; D006207:Half-Life; D006321:Heart / Q000503:physiopathology; D007275:Injections, Intravenous / Q000662:veterinary; D007700:Kinetics; D008297:Male
D004077:Digoxin