Acute saline expansion lowers blood pressure of early DOCA salt hypertensive rats.
Changes in blood pressure and body fluids volume caused by an acute saline load were studied in 6 normal and 7 DOCA-salt early hypertensive rats having normal inulin space and plasma volume. After loading, blood pressure increased in the normal group (+23 mm Hg) and fell (-17 mm Hg) in the DOCA-salt group. Expansion of extracellular fluid volume was similar in both groups but expansion of plasma volume was twice as high in the DOCA-salt than in the normal group. The results are compatible with an inhibition of a volume-sensitive vasopressor mechanism possibly involving vasopressin.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001810:Blood Volume / Q000187:drug effects; D003900:Desoxycorticosterone; D005110:Extracellular Space / Q000503:physiopathology; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D007444:Inulin / Q000502:physiology; D008297:Male; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology*
D003900:Desoxycorticosterone; D012965:Sodium Chloride; D007444:Inulin