title: [Granulocyte and thrombocyte substitution].
abstract: The high rate of production makes it necessary to provide large amounts of platelets or granulocytes to support patients with bone marrow failure. With cell separators up to 10 X 10(11) platelets and more than 2 X 10(10) granulocytes can be withdrawn from a single donor. Therefore the selection of HLA-compatible donor-recipient pairs is possible. Platelets should be given in patients with hämorrhage and low platelet values due to decreased production. The substitution with granulocytes should be restricted to patients suffering from severe granulocytopenia (less than 500 granulocytes/microliter) and life threatening infection and when bone marrow recovery can be assumed.
mesh_terms: D000017:ABO Blood-Group System; D001792:Blood Platelets; D001803:Blood Transfusion; D001855:Bone Marrow Diseases / Q000628:therapy*; D006680:HLA Antigens; D006648:Histocompatibility; D006801:Humans; D007937:Leukapheresis; D007962:Leukocytes; D010983:Plateletpheresis
chemical_list: D000017:ABO Blood-Group System; D006680:HLA Antigens
vernacular_title: Granulozyten- und Thrombozytensubstitution.