Diurnal circadian rhythms of electrolyte excretion and filtration rate in end-stage renal disease.
Diurnal excretory rhythms of Na, K, Cl and PO4 were measured in consecutive 3-hour urine collection periods in 2 subjects with advanced renal failure, one of whom was hypertensive, and had been edematous for 4 and 8 days, respectively. Inulin clearance was measured over a 39-hour span in the hypertensive patient. As compared with normal subjects studied under similar conditions, the amplitudes of all rhythms were depressed, the amplitude of K especially so. The rhythm of PO4 excretion was phase-shifted (late AM acrophase) in both patients. The rhythms of Na, Cl and K were phase-shifted in the hypertensive but not the normotensive patient. Ca and Mg rhythms measured in the normotensive subject were within normal limits of amplitude and phase, coinciding with those of Na and Cl. Amplitude of inulin clearance in the hypertensive patient was normal but with reversed phase.
D000328:Adult; D002940:Circadian Rhythm; D004573:Electrolytes / Q000652:urine*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000652:urine*
D004573:Electrolytes