title: [Cellular differentiation processes in normal squamous epithelium and initial stages of cervical neoplasia].
abstract: Nuclear size and ratio between DNA and nucleus were measured in 787 normal, pseudo-dyskaryotic and dyskaryotic cells of superficial and intermediary layers obtained from condylomatous lesions as well as from cases of atypical metaplasia and slight dysplasia, following Feulgen staining of the cytological specimens. All cell types occurred at different periods of time, as was observed in a longitudinal-section study. This, together with the data measured, was likely to suggest the biphasic nature of changes in cell nuclei, in that initially functional nuclear oedema (pseudo-dyskaryosis) was followed by differentiation towards the dyskaryotic cell. These processes were found to occur first to superficial cells and second to intermediary cells. In the phase of intermediary dyskaryosis the quantity of DNA was increased with significance by polyploidisation. All six cell populations differed from one another with significance by nuclear surface.
mesh_terms: D002454:Cell Differentiation; D002467:Cell Nucleus / Q000648:ultrastructure; D002584:Cervix Uteri / Q000166:cytology / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D011230:Precancerous Conditions / Q000473:pathology; D011446:Prospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
chemical_list: D004273:DNA, Neoplasm
vernacular_title: Zelluläre Differenzierungsvorgänge bei normalem Plattenepithel und bei Initialstadien zervikaler Neoplasie.