title: [Cardiac and vascular effects of midazolam during induction of anesthesia prior to and during extracorporeal circulation in coronary-surgical patients (author's transl)].
abstract: 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a] [1,4]benzodiazepine (midazolam, Ro 21-3981, Dormicum) is a new benzodiazepine which, when compared with its predecessors diazepam (Valium) and flunitrazepam (Rohypnol), has several outstanding advantages: We conducted hemodynamic investigations with 0.15 mg/kg b.w. midazolam in a total of 28 coronary patients divided into 3 groups. The new water-soluble benzodiazepine is at the dose given useful in the induction of and as an adjuvant to anesthesia because of its hemodynamic effect.
mesh_terms: D000777:Anesthetics / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003331:Coronary Vessels / Q000601:surgery; D005112:Extracorporeal Circulation; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008874:Midazolam; D008875:Middle Aged
chemical_list: D000777:Anesthetics; D001569:Benzodiazepines; D008874:Midazolam
vernacular_title: Kardiale und vaskuläre Effekte von Midazolam während der Narkoseeinleitung sowie vor und während der extrakorporalen Zirkulation bei koronarchirurgischen Patienten.