[On the influence of drugs on cellular mechanisms of resistance in the animal experiment/Activation of peritoneal macrophages of the mouse by a resistance stimulant on plant base (author's transl)].
Enzyme activity of lysosomal hydrolases and phagocytosis of Staphylococcus aureus were investigated in peritoneal macrophages of mice. After the in vivo stimulation by a single treatment with thioglycolate broth or a host-resistance stimulant on plant base (Esberitox) the elicited peritoneal macrophage population exhibited characteristics of activation. These non specifically activated macrophages secreted higher amounts of lysosomal enzymes and demonstrated a higher phagocytotic activity than resident macrophages.
D000818:Animals; D006596:Hexosaminidases / Q000378:metabolism; D007111:Immunity, Cellular / Q000187:drug effects*; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D013864:Thioglycolates / Q000494:pharmacology
D010936:Plant Extracts; D013864:Thioglycolates; C026057:Esberitox; D006596:Hexosaminidases
Uber die medikamentöse Beeinflussung zellulärer Resistenzmechanismen im Tierversuch. Aktivierung von Peritonealmakrophagen der Maus durch pflanzliche Reizkörper.