[Therapeutic field trial with praziquantel in a rural population in Mali infected with Schistosoma mansoni (author's transl)].
89 people from 6 to 60 years old living in two villages in the valley of the Oyako near Bamako (Mali) infected with S. mansoni, were treated with a single dose of 40 mg/kg bwt. 2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino [2,1-a]isoquinolin-4-one (praziquantel, EMBAY 8440, Biltricide). Side effects were recorded, a clinical and parasitological examination was effected 5 months later. If the results on efficacy can be confirmed, considering the ease of administration and the good acceptance by the patients praziquantel will be recommended for mass campaigns in Mali, where S. mansoni and especially S. haematobium are rapidly spreading following improvement of the water supply.
D000293:Adolescent; D000328:Adult; D002648:Child; D006801:Humans; D007546:Isoquinolines / Q000627:therapeutic use*; D008302:Mali; D008875:Middle Aged; D011223:Praziquantel / Q000627:therapeutic use*; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000188:drug therapy* / Q000469:parasitology
D007546:Isoquinolines; D011223:Praziquantel
Essai de traitement de masse par le praziquantel d'une population rurale malienne atteinte de bilharziose à S. mansoni.