[Pharmacological studies on the functional development of the central nervous system in first generation rats born to phenytoin-treated mothers (author's transl)].
We studied the effects of prenatal treatment with phenytoin (PHT) on the functional development of the rat brain. Pregnant rats were injected with varying doses (10, 50, 100 or 200 mg/kg) of PHT on days 1-21, 1-10, 14-21 or day 15 of pregnancy. There was no significant difference in the sleeping effect of pentobarbital, ataxic effect of diazepam, or seizure effect of pentetrazol between control-F1 and PHT-F1 rats. Prenatal treatment with PHT on days 1-21 of pregnancy induced a marked increase in the duration of haloperidol-induced catalepsy in the male and female F1 rats when tested once a week, beginning on the 9th week and until the 13th week after birth. Hypersensitivity to haloperidol was induced to a greater extent in females. On the other hand, prenatal treatment with PHT on days 14-21 or on day 15 of pregnancy induced a decline in the duration of haloperidol-induced catalepsy in both male and female F1 rats. There was no significant alteration in the growth of the PHT-F1 rats. However, their eye opening was accelerated. The present results suggest that prenatal exposure to phenytoin induces long-lasting alterations in the dopaminergic and/or other neurons related to the manifestation of cataleptic behavior in the rat brain.
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development; D001259:Ataxia / Q000139:chemically induced; D001723:Birth Rate; D001921:Brain / Q000254:growth & development*; D002375:Catalepsy / Q000139:chemically induced; D003975:Diazepam; D005123:Eye / Q000254:growth & development; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D006220:Haloperidol; D006801:Humans; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology*; D011247:Pregnancy; D011270:Pregnancy, Animal; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects
D010672:Phenytoin; D010424:Pentobarbital; D006220:Haloperidol; D003975:Diazepam