Primary aldosteronism caused by adrenal cortical carcinoma.
Adrenocortical carcinoma rarely produces pure primary aldosteronism. We document the occurrence of such a case. Through tumor steroid analysis, we show that the content of aldosterone per gram of tumor tissue is diminished compared to aldosterone producing adenomas. We also demonstrate the occurrence of angiotensin II receptors on the tumor, a finding hitherto noted only on aldosterone producing adenomas.
D000236:Adenoma / Q000097:blood / Q000150:complications*; D000304:Adrenal Cortex Function Tests; D000306:Adrenal Cortex Neoplasms / Q000150:complications* / Q000175:diagnosis; D000450:Aldosterone / Q000097:blood; D005938:Glucocorticoids / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006929:Hyperaldosteronism / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011945:Receptors, Angiotensin / Q000032:analysis
D005938:Glucocorticoids; D011945:Receptors, Angiotensin; D000450:Aldosterone; D006854:Hydrocortisone