Diuretic properties of a new acylaryloxyacetic acid: 2-(2',3'-dichloro-4'-carboxymethylene oxybenzoyl)-chromone.
An acyldichlorophenoxyacetic acid was synthetized in which the acyl group was chromone nucleus. This compound was tested in dogs for its saluretic and diuretic properties in comparison with thienylic acid. It exhibited weak but significant diuretic activity in respect to the reference compound.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004231:Diuresis / Q000187:drug effects*; D004232:Diuretics / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006016:Glycolates / Q000494:pharmacology*; D008297:Male; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine
D004232:Diuretics; D006016:Glycolates; C028925:2-(2',3'-dichloro-4'-carboxymethyleneoxybenzoyl)chromone; D012964:Sodium; D011188:Potassium