title: Effects of thioridazine on apomorphine-elicited stereotypic behavior and motor activity.
abstract: Bilaterally injected thioridazine (10 micrograms) into the striata of rats augmented the stereotypic behavior elicited by apomorphine. The enhancing effect was attenuated by pretreatment with alpha-methyl-p-tyrosine. At 48 hr postinjection of thioridazine (1.0 mg/kg, IP), motor suppression from a low dose of apomorphine (0.2 mg/kg, IP) was enhanced; however, motor response to a high dose of apomorphine (1 mg/kg, SC) was not affected. Possible mechanisms of action of thioridazine are discussed.
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*; D013881:Thioridazine / Q000494:pharmacology*
chemical_list: D001058:Apomorphine; D013881:Thioridazine