[Candida albicans spondylitis. Review of the literature apropos of a case with study of bone penetration of 5-fluorocytosine].
In spite of the development in cases of deep mycoses, cases of osteoarthritis with Candida remain rare (only thirty seven cases reported). Among these, ten observations of spondylodiscitis have been collected and the authors report a new case where Candida albicans was isolated in the discovertebral focus through bone puncture. This spondylodiscitis occurring in a leukemic patient receiving antibiotics, corticosteroids, cytostatics drugs and radiotherapy, was treated successfully by an association of Amphotericin B-5-Fluorocytosine. The authors take this opportunity to report the main characteristics of the ten previously described cases specifying the rules for the uses of fungicidal drugs in the treatment of deep mycoses and for the first time, they study simultaneously seric concentration, penetration into healthy bone and into discovertebral focus of the 5-Fluorocytosine. They also justify their preference for the association of Amphotericin B-5-Fluorocytosine as a "first line" treatment after confirming the sensitivity of the strain to 5-Fluorcytosine.
D000666:Amphotericin B / Q000627:therapeutic use; D002177:Candidiasis / Q000188:drug therapy*; D003596:Cytosine / Q000031:analogs & derivatives*; D004359:Drug Therapy, Combination; D005437:Flucytosine / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D007403:Intervertebral Disc / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013166:Spondylitis / Q000188:drug therapy / Q000209:etiology*
D000666:Amphotericin B; D003596:Cytosine; D005437:Flucytosine
Spondylodiscite à Candida albicans. Revue de la littérature à propos d'un cas avec étude de la pénétration osseuse de la 5-fluorocytosine.