[General and local humoral immunity and intestinal microflora in children with skin manifestations of food allergy].
The authors describe the results of studies into the common and local humoral immunological system in 60 children under one year of age suffering from atopic dermatitis of varying severity. The passive hemagglutination test with the use of a kit of erythrocytic diagnosticums devised at the Institute of Nutrition, Academy of Medical Sciences of the USSR, was used to study the degree of the child's body sensitization with cow's milk antigens and the content of IgG, IgM and IgA in the blood and that of secretory IgA in coprofiltrates. Polyvalent sensitization of the body with food antigens was found in 50% of the children examined to reveal an interplay between the degree of sensitization with the severity of the pathological process. It was demonstrated that penetration of food antigens through the epithelial barrier of the gastrointestinal tract was not related to the deficiency of the secretory IgA, since this class of immune proteins was detectable in the coprofiltrates from all the children. Besides, the content of these proteins was not reduced during the severe form of the disease. In this case, the intestine of all the children examined showed dysbacteriosis which needed correction. The blood serum manifested a decrease in the level of IgM and IgG which was more pronounced in the patients with a severe disease course.
D000917:Antibody Formation; D003876:Dermatitis, Atopic / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D004755:Enterobacteriaceae; D005243:Feces / Q000032:analysis / Q000382:microbiology; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D008297:Male
D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Kharakteristika obshcheĭ i lokal'noĭ gumoral'noĭ immunologicheskoĭ sistemy i kishechnogo mikrobiotsenoza u deteĭ s kozhnymi proiavleniiami pishchevoĭ allergii.