[Estrogens as modulators of dopamine activity in the regulation of the gonadotropic function of the pituitary gland].
The effect of dopamine (DA), injected into arcuate nucleus-medial eminence (ARC-ME) region, on luteinizing hormone (LH) secretion, was studied in intact female rats, depending on the estrual cycle stage and in ovariectomized )OE) rats previously treated with estradiol benzoate (OE + E) or untreated animals. The increased blood LH concentration was recorded 30 minutes after dopamine injection during the second half of the 2-diestrus day and in the morning of the proestrus stage. DA injection into ARC-ME to OE rats lowered the blood and hypophyseal LH levels, whereas the increased blood Lh concentration was seen in OE + E rats. From the data obtained it was concluded that the hypothalamic dopaminergic system participates in the ovulatory LH-release regulation, while DA effect on gonadotropic function is determined by the peripheral blood estrogen level.
D000818:Animals; D002369:Castration; D003864:Depression, Chemical; D004298:Dopamine / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology*; D045166:Estradiol Congeners / Q000494:pharmacology; D004971:Estrus; D005260:Female; D007986:Luteinizing Hormone / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D013268:Stimulation, Chemical
D045166:Estradiol Congeners; D004958:Estradiol; D007986:Luteinizing Hormone; D004298:Dopamine
Estrogeny kak moduliatory deĭstviia dofamina v reguliatsii gonadotropnoĭ funktsii gipofiza.