Effect of fenvalerate on kynurenine metabolizing enzymes and acid ribonuclease of mouse liver.
The effects of fenvalerate, a pyrethroid insecticide, were studied on some mouse liver enzymes. Given orally, either in a single dose of 60 mg/kg or in a six daily doses of 20 mg/kg, fenvalerate reduced the activity of the B6-dependent kynurenine hydrolase (KH), but increased that of kynurenine aminotransferase (KATE) and beta-glucuronidase (beta-Glase). While the single dose treatment with fenvalerate had no effect on acid ribonuclease (RNase), the repeated treatments increased the activity of this enzyme. This study demonstrates that fenvalerate can alter the kynurenine metabolizing enzymes and acid ribonuclease of mouse liver.
D000818:Animals; D005966:Glucuronidase / Q000032:analysis; D006867:Hydrolases / Q000032:analysis*; D007306:Insecticides / Q000009:adverse effects*; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008190:Lyases; D008297:Male; D051379:Mice; D009570:Nitriles; D011722:Pyrethrins / Q000009:adverse effects*; D012260:Ribonucleases / Q000032:analysis*; D000637:Transaminases / Q000032:analysis*
D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; D000637:Transaminases; C427605:glutamine - phenylpyruvate transaminase; C021481:kynurenine-oxoglutarate transaminase; D006867:Hydrolases; D012260:Ribonucleases; D005966:Glucuronidase; C021480:kynureninase; D008190:Lyases; C017690:fenvalerate