The genetical difference between the DBA/2 and C57Bl/6 strains in cortisone-induced cleft palate.
The DBA/2 strain of mice is about five times more sensitive than the C57B1/6 strain to cortisone-induced cleft palate. There is a matroclinous reciprocal cross difference. Appropriate backcrosses indicate that the basis of this reciprocal cross difference is not cytoplasmic. A biometric model including additive and dominance components adequately explains the data. Since dominance has been demonstrated in other strains and crosses, it is suggested that a trait correlated to cortisone-induced cleft palate has been exposed to directional selection.
D000014:Abnormalities, Drug-Induced / Q000235:genetics*; D000818:Animals; D002972:Cleft Palate / Q000139:chemically induced* / Q000235:genetics; D003348:Cortisone / Q000009:adverse effects*; D003433:Crosses, Genetic; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008957:Models, Genetic
D003348:Cortisone