Cimetidine and adrenals.
An H2-antagonist, cimetidine, reduces in the rat normal plasma corticosterone levels and strongly antagonizes their increase after cold stress. This latter effect is dose dependent. Plasma corticosterone reduction by cimetidine lasts 4 h both in normal and stress situations. Both a hypophyseal or adrenal site of action of the drug may be involved in the inhibition of adrenocortical secretion.
D000311:Adrenal Glands / Q000187:drug effects*; D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D003080:Cold Temperature; D003345:Corticosterone / Q000097:blood; D006146:Guanidines / Q000494:pharmacology*; D008297:Male; D005082:Physical Exertion; D051381:Rats; D013312:Stress, Physiological / Q000503:physiopathology; D013997:Time Factors
D006146:Guanidines; D002927:Cimetidine; D003345:Corticosterone