Urinary pseudouridine/creatinine ratio as an indicator of gastrointestinal cancer.
Urinary pseudouridine/creatinine ratio was determined in 74 patients with gastrointestinal tumours and 34 patients with no known malignant disease. The reproducibility of a single random urine sample was demonstrated. The mean ratio for control patients was 26.9 +/- 7.7 nmol/mumol and no control patient exceeded the mean by 2 standard deviations. There was no difference in the ratio between the sexes. Sixty-five per cent of colon cancer patients and 37.5 per cent of gastric and rectal cancer patients exceeded this upper limit of normality. There was no correlation between pseudouridine/creatinine ratio and histological differentiation, liver involvement or stage in either colorectal or gastric cancer patients. Urinary pseudouridine/creatinine ratio is one of the better non-specific cancer markers and may be particularly useful for detecting colonic cancer.
D003110:Colonic Neoplasms / Q000652:urine; D003404:Creatinine / Q000652:urine*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011560:Pseudouridine / Q000652:urine*; D012004:Rectal Neoplasms / Q000652:urine; D012016:Reference Values; D014529:Uridine / Q000031:analogs & derivatives*
D011560:Pseudouridine; D003404:Creatinine; D014529:Uridine