Chronic effects of PGBx, a polymeric prostaglandin, on blood leukocyte counts.
PGBx, a polymeric prostaglandin, in chronic doses therapeutic for hereditary diabetes and hereditary obesity in mice, produces significant increases of blood neutrophils and lymphocytes in normal mice, hereditary diabetic mice, and hereditary obese mice. For lymphocytes, but not for neutrophils, the direction of the PGBx effect reverses at doses above 10 micrograms/g of body weight.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood; D007958:Leukocyte Count; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D008820:Mice, Obese / Q000097:blood; D009504:Neutrophils / Q000187:drug effects; D011108:Polymers / Q000627:therapeutic use; D011453:Prostaglandins / Q000494:pharmacology*; D011456:Prostaglandins B / Q000494:pharmacology* / Q000627:therapeutic use
D011108:Polymers; D011453:Prostaglandins; D011456:Prostaglandins B; C024303:prostaglandin Bx