Comparative analgesic, behavioral, and dependence properties of morphine and O-(4-methoxylphenylcarbamoyl)-3-diethylaminopropiophenone oxime hydrochloride.
The analgesic activity of O-(4-methoxylphenylcarbamoyl)-3-diethylaminopropiophenone oxime hydrochloride was investigated in Swiss--Webster mice using an electroshock technique in which the pain threshold was the minimum voltage producing tonic extension of the hindlimbs in response to an electroshock delivered to the feet. The analgesic potency of O-(4-methoxylphenylcarbamoyl)-3-diethylaminopropiophenone oxime hydrochloride was equal to, or greater than, that of morphine. Neither nalorphine nor withdrawal produced visible behavioral effects in rats treated with O-(4-methoxylphenylcarbamoyl)-3-diethylaminopropiophenone oxime hydrochloride for 21 days, suggesting that the physical dependency liability of the compound may be less than that of morphine.
D000700:Analgesics; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D006801:Humans; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009269:Nalorphine / Q000494:pharmacology; D010091:Oximes / Q000494:pharmacology*; D011427:Propiophenones; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D012684:Sensory Thresholds / Q000187:drug effects; D019966:Substance-Related Disorders / Q000209:etiology* / Q000503:physiopathology
D000700:Analgesics; D010091:Oximes; D011427:Propiophenones; D009020:Morphine; C015681:anidoxime; D009269:Nalorphine