title: [Combination chemotherapy of transplanted rat leukemia L 5222 with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and cyclophosphamide (CPA) as well as with methyl-CCNU and CPA (author's transl)].
abstract: The acute transplanted rat leukemia L 5222 was used to investigate the two-drug combinations 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and cyclophosphamide (CPA) as well as methyl-CCNU and CPA. A therapeutic synergism could not be demonstrated in either combination. In both combinations the monotherapy with the nitrosourea was superior to the combination as well as to the monotherapy with CPA.
mesh_terms: D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008130:Lomustine / Q000627:therapeutic use*; D008297:Male; D009368:Neoplasm Transplantation; D009607:Nitrosourea Compounds / Q000627:therapeutic use*; D051381:Rats; D012673:Semustine / Q000627:therapeutic use*; D014184:Transplantation, Homologous
chemical_list: D009607:Nitrosourea Compounds; D012673:Semustine; D008130:Lomustine; D003520:Cyclophosphamide
vernacular_title: Kombinationschemotherapie der transplantierten Rattenleukämie L 5222 mit 1-(2-Chloräthyl)-3-cyclohexyl-1-nitrosoharnstoff (CCNU) und Cyclophosphamid sowie milt Methyl-CCNU und Cyclophosphamid.