title: Intraventricular hemorrhage--an animal model.
abstract: Hemodynamic monitoring was carried out in 9 newborn beagle puppies exposed to hypercarbic insult. 4 animals were exposed to slowly increasing carbon dioxide tensions without hypoxemia; 5 animals were exposed to rapid, intense increase in carbon dioxide tensions without hypoxemia. 2 of the 5 puppies (40%) exposed to the rapid hypercarbia developed intraventricular hemorrhage characteristic of that found in the immature human. All of the puppies exhibited germinal matrix layers comparable to those of 30- to 32-week gestational age human infants. Significantly higher systemic arterial and jugular venous pressures were documented during the baseline and experimental periods in the 2 animals that bled. A predisposition to hemorrhage may have been present in these 2 animals because of hypertension in the baseline period. This preliminary study demonstrates that a histological model for IVH exists in an animal which is stable enough for extensive hemodynamic monitoring.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002245:Carbon Dioxide; D002543:Cerebral Hemorrhage / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D005865:Gestational Age; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D007231:Infant, Newborn; D007234:Infant, Premature; D010313:Partial Pressure; D011247:Pregnancy; D012039:Regional Blood Flow
chemical_list: D002245:Carbon Dioxide