Biological properties of cis- and trans- dichlorodiammineplatinum.
Cis- and Trans- dichlorodiammineplatinum (II) inhibit the development of the sea urchin eggs. The inhibition is prevented by N-acetylcysteine, glutathione and alpha-mercaptopropionylglycine. Sulfhydril groups appear as a cellular target for these platinum compounds.
D000111:Acetylcysteine / Q000494:pharmacology; D000818:Animals; D001755:Blastocyst / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology*; D005260:Female; D005775:Gastrula / Q000187:drug effects; D005978:Glutathione / Q000494:pharmacology; D012617:Sea Urchins; D013237:Stereoisomerism; D008625:Tiopronin / Q000494:pharmacology; D015053:Zygote / Q000166:cytology / Q000187:drug effects*
D008625:Tiopronin; D005978:Glutathione; D002945:Cisplatin; D000111:Acetylcysteine