Effect of pesticide exposure on human microsomal enzyme induction.
1 The antipyrine half-life, metabolic clearance rate and the apparent volume of distribution were measured in six subjects handling malathion. These results were compared with six appropriate controls. 2 Occupational exposure of malathion in subjects reduced the antipyrine half-life from 9.18 +/- 2.16 h in controls to 4.73 +/- 1.65 h. 3 It is concluded that malathion exposure increases the rate of antipyrine elimination, possibly by inducing the hepatic microsomal enzymes.
D000328:Adult; D000983:Antipyrine / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects*; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008294:Malathion / Q000009:adverse effects; D008297:Male; D008861:Microsomes / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009784:Occupational Diseases / Q000201:enzymology; D010575:Pesticides / Q000494:pharmacology*
D010575:Pesticides; D006899:Mixed Function Oxygenases; D000983:Antipyrine; D008294:Malathion