Precursor stage of hepatocellular neoplasm following long exposure to orally administered contraceptives.
Hepatic neoplasms and peliosis are known to occur in women taking contraceptives orally. We observed hyperplasia of hepatocytes combined with hypertrophy of sinusoidal lining cells and sinusoidal dilatation with progression to peliosis in the liver of a patient who had been taking such contraceptives for 10 years. These changes resembled the precursor stage in the development of hepatic angiosarcoma induced by vinyl chloride, Thorotrast, and arsenic. In users of orally administered contraceptives these findings may precede the development of hepatocellular neoplasms.
D000328:Adult; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects*; D005260:Female; D006394:Hemangiosarcoma / Q000139:chemically induced*; D006801:Humans; D006965:Hyperplasia; D006984:Hypertrophy; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced*; D011230:Precancerous Conditions / Q000139:chemically induced* / Q000473:pathology
D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined