title: [Effects of oxilofrine on the release and storage of noradrenaline in cardiac sections of the rat (author's transl)].
abstract: Experiments in vitro have shown 1-(4-hydroxyphenyl)-2-methylamino-propanol-(1) (oxilofrine, 4-HMP) to release noradrenaline from cardiac ventricular sections. This effect sets in at a concentration of 10(-5) mol/l and reaches the 30% level at 5X10(-5) mol/l. The inhibition of noradrenaline storage is still more pronounced. At 5 X 10(-5) mol/l the inhibition is 60%. The significance of both mechanisms of action of the sympathomimetic agent is discussed in comparison with compounds of related structure.
mesh_terms: D000818:Animals; D004809:Ephedrine / Q000031:analogs & derivatives*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats; D013566:Sympathomimetics / Q000494:pharmacology*
chemical_list: D011412:Propanolamines; D013566:Sympathomimetics; C026055:oxilofrine; D004809:Ephedrine; D009638:Norepinephrine
vernacular_title: Wirkungen von Oxilofrin auf Freisetzung und Einspeicherung von Noradrenalin in Herzschnitten der Ratte.