title: Protein turnover in brain during the development of alcohol dependence.
abstract: The chronic effect of ethanol on central nervous system protein turnover was investigated in selected regions of brain following intoxication and withdrawal in a strain of ethanol preferring mice. Mice were serially injected with [14C]glucose in order to achieve a constant specific radioactivity of brain glutamate. Protein turnover was calculated from the specific activities of extracted protein and free glutamate. Results from these studies show that ethanol causes a significant increase in protein turnover in all sections of brain. The brain protein turnover in animals following alcohol withdrawal also shows an increase which deviates significantly from controls in 2 of the 3 regions examined.
mesh_terms: D000428:Alcohol Drinking; D000437:Alcoholism / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D000431:Ethanol / Q000009:adverse effects; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D008032:Limbic System / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009830:Olfactory Bulb / Q000378:metabolism; D013375:Substance Withdrawal Syndrome / Q000378:metabolism
chemical_list: D000596:Amino Acids; D009419:Nerve Tissue Proteins; D000431:Ethanol