Effect of food on bioavailability of chloroquine.
The bioavailability of chloroquine in 7 healthy adult and volunteers was assessed with and without a standard breakfast. Chloroquine (600 mg base) was administered orally and timed blood samples were obtained for determination of plasma concentrations. The results suggest that the AUC and peak plasma levels were significantly higher when chloroquine was administered together with food, although the rate of absorption was not different. It appears, therefore, that food facilitates chloroquine absorption and the extent of absorption is significantly modified. Hence administration of chloroquine together with food appears to be an advisable clinical practice.
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002738:Chloroquine / Q000097:blood / Q000378:metabolism*; D005502:Food; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male
D002738:Chloroquine