Low incidence of X-chromatin in congenital hypothyroidism.
Buccal smears of 5 female patients with hypothyroidism (3 with congenital hypothyroidism or cretinism and 2 with acquired type) were studied for X-chromatin. Very low incidence of X-chromatin positive cells (1.33%, 1.59% and 2.06%) was found in all the three cases with cretinism while the incidence was the same (15.0% and 15.61%) as in the control females (15.5%), in 2 cases with acquired hypothyroidism. Chromosome studies were carried out in two cases of cretinism. They had a normal karyotype, 46 XX.
D000293:Adolescent; D002648:Child; D003409:Congenital Hypothyroidism / Q000151:congenital / Q000235:genetics*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006801:Humans; D007037:Hypothyroidism / Q000235:genetics; D012728:Sex Chromatin
D012739:Gonadal Steroid Hormones