Uptake and distribution of radioactive selenium in cataractous rat lens.
A cataractous dose of sodium selenite tagged with 75Se was injected into 10 day old rat pups. It was shown for the first time that 75Se accumulated in the soluble and insoluble proteins of the lens. 75Se was not concentrated in the nuclear cataract. Interaction of selenium with structural or enzymatic proteins of the lens may be an important step in the mechanism of selenite induced cataract.
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000378:metabolism; D003459:Crystallins / Q000378:metabolism; D005260:Female; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D007908:Lens, Crystalline / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium / Q000378:metabolism*
D003459:Crystallins; D012643:Selenium