title: Histidine-rich protein of the keratohyalin granules. Source of the free amino acids, urocanic acid and pyrrolidone carboxylic acid in the stratum corneum.
abstract: The pool of free amino acids, urocanic acid and pyrrolidone carboxylic acid in mammalian stratum corneum has been shown to be derived principally or totally from the histidine-rich protein of the keratohyalin granules. The time course of appearance of free amino acids and breakdown of the histidine-rich protein are similar, as are the analyses of the free amino acids and the histidine-rich protein. Quantitative studies show that between 70 and 100% of the total stratum corneum-free amino acids are derived from the histidine-rich protein.
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000818:Animals; D006168:Guinea Pigs; D006639:Histidine / Q000008:administration & dosage / Q000032:analysis*; D007093:Imidazoles / Q000032:analysis*; D007271:Injections, Intradermal; D008297:Male; D011506:Proteins / Q000032:analysis*; D011760:Pyrrolidinones / Q000032:analysis*; D011761:Pyrrolidonecarboxylic Acid / Q000032:analysis*; D012867:Skin / Q000032:analysis*; D013997:Time Factors; D014560:Urocanic Acid / Q000032:analysis*
chemical_list: D000596:Amino Acids; D007093:Imidazoles; D011506:Proteins; D011760:Pyrrolidinones; D006639:Histidine; D014560:Urocanic Acid; D011761:Pyrrolidonecarboxylic Acid