title: Sexual receptivity: brain sites of estrogen action in female hamsters.
abstract: In order to investigate the brain sites of estrogen action, ovariectomized hamsters were stereotaxically implanted with unilateral 27 gauge cannulae containing estradiol. Groups of females received implants into either the lateral septum, bed nucleus of the stria terminalis, preoptic area, anterior hypothalamus, ventromedial hypothalamus, arcuate nucleus, corticomedial amygdala or mesencephalic central gray. Another set of animals received implants containing cholesterol. One week later the animals were injected with progesterone and 4-5 hours later tested for sexual receptivity. The most receptivity and the most consistent response was seen in females with estradiol implants in the ventromedial hypothalamus. Only a few scattered animals in the other anatomical groups showed any receptivity. Only in animals with implants in the anterior hypothalamus was there any evidence of leakage of estrogen into peripheral circulation as measured by uterine weight. There was no response in females with cholesterol implants. Our results suggest that the ventromedial hypothalamus is the most sensitive brain area for the estrogenic induction of female sexual receptivity in hamsters.
mesh_terms: D000679:Amygdala / Q000187:drug effects; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects; D006224:Cricetinae; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007031:Hypothalamus / Q000187:drug effects; D008647:Mesocricetus; D009434:Neural Pathways / Q000187:drug effects; D010487:Periaqueductal Gray / Q000187:drug effects; D011960:Receptors, Estrogen / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects*
chemical_list: D011960:Receptors, Estrogen; D004958:Estradiol