Further evidence for a GABA-like action on kojic amine.
Data are reported to support the hypothesis that kojic amine is a GABA agonist in an in vivo model of GABAergic activity. The unilateral intranigral microinjection of kojic amine elicited dose-related turning contraversive from the injection site. The direction of the turning is identical to that observed after the intranigral administration of muscimol or other GABA agonists. Furthermore, the numbers of turns elicited by kojic amine was significantly reduced following pretreatment with the GABA antagonist, bicuculline. The results suggest that kojic amine is a GABA agonist.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D005260:Female; D006801:Humans; D007276:Injections, Intraventricular; D011714:Pyrans / Q000494:pharmacology*; D011753:Pyrones / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012399:Rotation; D013239:Stereotyped Behavior / Q000187:drug effects*; D013378:Substantia Nigra / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D011714:Pyrans; D011753:Pyrones; D005680:gamma-Aminobutyric Acid; C018990:kojic amine; D001640:Bicuculline