Effect of azathioprine on antibody formation in mice and its modification by delta-(2-amino-6-hydroxy-3,4-dihydro-4-oxo-5-pyrimidinyl)-valeric acid.
The effects of azathioprine, either alone or combined with delta-(2-amino-6-hydroxy-3,4-dihydro-4-oxo-5-pyrimidinyl)-valeric acid (VUFB-9777, Damvar) on serum antibody formation was studied in mice. The immunosuppressive effect of azathioprine depended on the regimen of administration. VUFB-9777 alone produced no immunosuppressive effect but markedly enhanced that of azathioprine.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001379:Azathioprine / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006386:Hemagglutination Tests; D006461:Hemolysis / Q000187:drug effects; D051379:Mice; D011744:Pyrimidinones / Q000494:pharmacology*; D012756:Sheep / Q000276:immunology; D013997:Time Factors
D011744:Pyrimidinones; C019161:damvar; D001379:Azathioprine