[Myocardial protection by a carnosine-buffered cardioplegic solution (author's transl)].
A carnosine-buffered, Na+-poor and Ca2+-free cardioplegic solution with pH 7.40 and physiological osmolarity was developed. The effect on the myocardium was more protective than that obtained with a corresponding unbuffered solution or a Mg-aspartate-procaine solution. The metabolic state of rabbit hearts was investigated up to 8 h of ischemia at 15 degrees C. A constant glycolytic rate was observed up to 6 h and the ATP content was maintained at 83% of controls. The ratio of glycolytic ATP production vs. total turnover of high-energy phosphates was 0.85. The small difference between energy demand and production may effect the conditions for good recovery.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002336:Carnosine / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D006324:Heart Arrest, Induced / Q000379:methods*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011817:Rabbits
D004151:Dipeptides; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D002336:Carnosine; D000255:Adenosine Triphosphate
Myokardprotektion durch eine Carnosin-gepufferte kardioplegische Lösung.