[In vitro effect of Iopamidol on coagulation, fibrinolysis and complement system (author's transl)].
Experiments on the effect of iopamidol on coagulation, fibrinolysis and complement system by in vitro standard tests were undertaken. No effect on thrombin time and thrombincoagulase time were found in clinically relevant concentration range. In contrast to classical triiodinated contrast media indications of inhibition of fibrin polymerization could only be found at large doses of iopamidol. No generation of fibrinolytic split products as indication of activation of fibrinolysis were found. Crossed immunoelectrophoresis at different concentrations could not detect split products of the complement protein C3.
D001777:Blood Coagulation / Q000187:drug effects*; D003176:Complement C3 / Q000032:analysis; D003165:Complement System Proteins / Q000378:metabolism*; D003287:Contrast Media / Q000494:pharmacology*; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007479:Iopamidol; D007483:Iothalamic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D013918:Thrombin Time
D003176:Complement C3; D003287:Contrast Media; D007483:Iothalamic Acid; D003165:Complement System Proteins; D007479:Iopamidol
Die In-vitro-Wirkung von Iopamidol auf Gerinnung, Fibrinolyse und Komplementsystem.