Reduction of exogenous oxalate in urine of rats by binding with aluminium-oxyhydrate (Andursil) and an anion-exchanger (Colestid) in the intestinal tract.
The influence of calcium carbonate, aluminium oxyhydrate (Andursil) and an anion exchanger (Colestid) on the absorption of oxalate from the intestine in rats was investigated. The animals were administered daily doses of 15mg oxalate as a 14C-sodium-oxalate solution by means of a throat probe, and the substances of interest were mixed with the food. The intake of food and the 14C-activity in the urine were measured during four urine-collecting periods of 3 days each. The quantity of the enterally administered oxalate excreted with urine has a negative correlation to the amount of the investigated test substances ingested with food.
D000536:Aluminum Hydroxide / Q000494:pharmacology*; D000818:Animals; D000837:Anion Exchange Resins / Q000494:pharmacology*; D002119:Calcium Carbonate / Q000494:pharmacology; D003084:Colestipol / Q000494:pharmacology*; D004129:Dimethylpolysiloxanes / Q000494:pharmacology*; D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects*; D007475:Ion Exchange Resins / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology*; D008276:Magnesium Hydroxide / Q000494:pharmacology*; D010070:Oxalates / Q000378:metabolism* / Q000652:urine; D011073:Polyamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012828:Silicones / Q000494:pharmacology*; D014545:Urinary Calculi / Q000188:drug therapy
D000837:Anion Exchange Resins; D004129:Dimethylpolysiloxanes; D004338:Drug Combinations; D007475:Ion Exchange Resins; D010070:Oxalates; D011073:Polyamines; D012828:Silicones; C010536:aluminum hydroxide, dimethylpolsiloxane, magnesium carbonate, magesium hydroxide drug combination; D000536:Aluminum Hydroxide; D002119:Calcium Carbonate; D008274:Magnesium; D003084:Colestipol; D008276:Magnesium Hydroxide