Uptake of elemental mercury and activity of catalase in rat, hamster, guinea-pig, normal and acatalasemic mice.
Uptake of elemental mercury after inhalation (3.5 mg/m3) and the activity of catalase in brain, liver, kidney and blood were investigated in rat, hamster, guinea-pig, and normal and acatalasemic mice. The uptake of mercury in the species investigated varied considerably, being highest in the two strains of mice, followed by rat and hamster, and lowest in the guinea-pig. The uptake seemed to be more dependent on pulmonary ventilation than on the activity of catalase. The two strains of mice were exposed to a wide range of mercury concentrations in air (0.002-3.5 mg/m3). The content of mercury in brain, liver and kidney was linearly dependent on the mercury concentration in the air, whereas in blood this relationship was exponential. At the lower concentrations of mercury in the inhaled air, the mercury level in blood was significantly lower, and in kidney higher in the acatalasemic mice compared to the normal ones. In acatalasemic mice the mercury content in liver was higher at all concentrations investigated, whereas in brain no difference between the two strains was found.
D020642:Acatalasia; D000818:Animals; D001822:Body Burden; D002374:Catalase / Q000378:metabolism*; D006224:Cricetinae; D006168:Guinea Pigs; D008168:Lung / Q000502:physiology; D008628:Mercury / Q000378:metabolism*; D008647:Mesocricetus; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D014018:Tissue Distribution
D002374:Catalase; D008628:Mercury