Cure of cryptococcemia in an immunocompromised patient with lupus nephritis.
The first documented cure of cryptococcosis with cryptococcemia is reported. The patient had systemic lupus erythematosis and had received corticosteroids and immunosuppressive drugs for diffuse proliferative nephritis. She had additional poor prognostic factors including high serum cryptococcal antigen titer, low cerebrospinal leukocyte count, and absence of anticryptococcal antibody. Pulmonary tuberculosis was diagnosed concurrently and subsequently she developed disseminated herpes zoster. During amphotericin B therapy, renal function worsened. Cure of cryptococcosis with cryptococcemia was accomplished despite multiple concurrent infections and transient worsening of renal function.
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use*; D003453:Cryptococcosis / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006562:Herpes Zoster / Q000150:complications; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D009393:Nephritis / Q000150:complications*; D011024:Pneumonia, Viral / Q000150:complications; D014397:Tuberculosis, Pulmonary / Q000150:complications
D007166:Immunosuppressive Agents; D000666:Amphotericin B