Iodine metabolism in mothers of children with cleft lip and/or palate anomaly and in persons with endemic goitre.
The authors examined 106 subjects with simple goitre and 18 hyperthyroid subjects who themselves or their ancestors came from endemic areas, furthermore 31 mothers of children with cleft lip and/or palate and 50 subjects acting as controls. The biochemical indicators in endemic goitre were at the borderline of hypothyroidism, in mothers of children with clefts on the borderline of hyperthyroidism. The authors conclude that genetically conditioned endemic mild thyroid hypofunction still persists in our population nad that it must be taken into consideration during the examination and treatment of thyropathies. The thyroid metabolism of mothers of children with cleft lip and/or palate differs significantly in many indicators from the endemic group and preconceptional and early prenatal prevention should be focused on elimination of possible marginal hyperthyroidism. The necessity to examine the thyroid metabolism of the mother as part of preconceptional genetic care was confirmed by these results.
D000328:Adult; D002784:Cholesterol / Q000097:blood; D002971:Cleft Lip / Q000209:etiology*; D002972:Cleft Palate / Q000209:etiology*; D005260:Female; D006043:Goiter, Endemic / Q000378:metabolism*; D006801:Humans; D006980:Hyperthyroidism / Q000378:metabolism; D007455:Iodine / Q000097:blood / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013974:Thyroxine / Q000097:blood
D007455:Iodine; D002784:Cholesterol; D013974:Thyroxine