title: Fenticonazole, a new imidazole derivative with antibacterial and antifungal activity. In vitro study.
abstract: The activity of alpha-(2,4-dichlorophenyl)-beta,N-imidazolylethyl 4-phenylthiobenzyl ether nitrate (fenticonazole, Rec 15/1476) compared with those of reference drugs, was tested in vitro on various bacteria and fungi. This compound showed in vitro an excellent activity against gram-positive microorganisms. The antifungal activity spectrum is very broad: dermatophytes, yeasts and dimorphic fungi were the most susceptible organisms. Fenticonazole showed in vitro at pH range 4-5 the highest activity against yeasts. The addition of inactivated bovine serum to the culture medium led to a slight decrease in activity of all the tested substances.
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000494:pharmacology*; D066298:In Vitro Techniques
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D007093:Imidazoles; C033486:fenticonazole