Inability of niacin to protect from in vivo hyperoxia or in vitro microsomal lipid peroxidation.
The efficacy of niacin in protecting rats from normobaric hyperoxia was evaluated in vivo by exposing niacin treated animals and controls to greater than 95% O2 for 96 hours. The vitamin was also evaluated as a possible free radical scavenger in vitro using an Fe-ascorbate initiated microsomal lipid peroxidation system. No protective effects were observed in vivo either in mortality or in differences in lung wet and dry weights of the niacin treated rats when compared to controls. Niacin in varying concentrations also did not decrease lipid peroxidation in the microsomal systems. Although this vitamin has been reported to protect animals from paraquat toxicity when given intraperitoneally once daily, niacin administered in similar doses does not appear to protect rats from hyperoxia.
D000818:Animals; D001273:Atmosphere Exposure Chambers; D008168:Lung / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D008563:Membrane Lipids; D008861:Microsomes / Q000187:drug effects*; D008862:Microsomes, Liver / Q000187:drug effects; D009525:Niacin / Q000494:pharmacology*; D010100:Oxygen / Q000506:poisoning*; D051381:Rats; D011919:Rats, Inbred Strains; D014811:Vitamin E Deficiency / Q000378:metabolism
D008563:Membrane Lipids; D009525:Niacin; D008315:Malondialdehyde; D010100:Oxygen