Effects of piribedil on schedule-controlled responding of the pigeon.
The effects of piribedil were studied in pigeons responding under a multiple fixed-ratio 30-response, fixed-interval 5-minute schedule of food presentation. Piribedil (0.03-10 mg/kg) increased responding under the fixed-interval component to a much greater extent than d-amphetamine (0.3-3 mg/kg) did. The rate-increasing effects of piribedil on fixed-interval responding were attenuated by haloperidol (0.003 and 0.03 mg/kg), alpha-methyl-p-tyrosine (50, 100 and 200 mg/kg), and tetrabenazine (10 and 30 mg/kg). These drug interactions suggest that piribedil acts as an indirect-acting, dopaminergic agonist to produce its rate-increasing effects on schedule-controlled responding in the pigeon.
D000818:Animals; D010856:Columbidae; D003216:Conditioning, Operant / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D008781:Methyltyrosines / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology*; D010891:Piribedil / Q000494:pharmacology*; D012055:Reinforcement Schedule; D013747:Tetrabenazine / Q000494:pharmacology; D013998:Time Perception / Q000187:drug effects*; D019805:alpha-Methyltyrosine
D008781:Methyltyrosines; D010879:Piperazines; D019805:alpha-Methyltyrosine; D010891:Piribedil; D006220:Haloperidol; D003913:Dextroamphetamine; D013747:Tetrabenazine