[Four benzamides (metoclopramide, sulpiride, sultopride and tiapride) effects on the oestrus cycle of the female rat: a comparative statistical study (author's transl)].
The comparative study of 4 Benzamides effects on the oestrus cycle of female rats has been done. These compounds were administered once daily for 21 consecutive days (1; 0,1; and 0,001 mg.kg-1.SC) on Wistar AF SPF rats smears. Our data show that sulpiride and sultopride suppress oestrus cycle substituted by a permanent dioestrus, while metoclopramide only extend the duration of the cycle and tiapride does not influence oestrus cycle.
D000077582:Amisulpride; D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D004971:Estrus / Q000187:drug effects*; D005260:Female; D008787:Metoclopramide / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D013469:Sulpiride / Q000031:analogs & derivatives / Q000494:pharmacology; D013976:Tiapamil Hydrochloride / Q000494:pharmacology
D001549:Benzamides; D013469:Sulpiride; D000077582:Amisulpride; D008787:Metoclopramide; D013976:Tiapamil Hydrochloride
A propos des effets de quatre benzamides (métoclopramide, sulpiride, sultopride, tiapride) sur le cycle oestral de la rate.