title: Management of leukaemia-associated disseminated intravascular coagulation (DIC).
abstract: Seven patients presenting with DIC in association with acute promyelocytic and myelomonocytic leukaemia were treated with intensive chemotherapy (IC), intensive platelet support (IPS) and continuous heparinization (CH), or IC + CH but minimal platelet support (MPS), or no chemotherapy, no heparin or MPS. All four patients who received IC + IPS + CH achieved remission (survival time: 516, 400+, 371 and 368 days). The remaining three patients died early (survival time: 11, 7 and 3 days). The results suggest that a combination of IC + IPS + CH is essential in the management of leukaemia-related DIC.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D001803:Blood Transfusion; D002648:Child; D004211:Disseminated Intravascular Coagulation / Q000628:therapy*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007938:Leukemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D017713:Platelet Transfusion
chemical_list: D005340:Fibrinogen; D006493:Heparin