[Mechanism of action of vitamin B1, thiamine pyrophosphate, and FAD on smooth muscle cells].
The contractile activity of the guinea pig taenia coli longitudinal muscle was studied as affected by exogenic thiamine, thiamine pyrophosphate and FAD. The mentioned substances in a concentration of 1 . 10(-3) M relax the smooth-muscular cells. Against a background of apamine FAD causes a contraction of taenia coli, which is not observed with application of thiaminepyrophosphate. Evidently, there are two, types of receptors sensitive to FAD and one sensitive to vitamin B1 on the membrane of the smooth-muscular cell.
D000818:Animals; D003106:Colon; D005182:Flavin-Adenine Dinucleotide / Q000494:pharmacology*; D006168:Guinea Pigs; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D013831:Thiamine / Q000494:pharmacology*; D013835:Thiamine Pyrophosphate / Q000494:pharmacology*
D005182:Flavin-Adenine Dinucleotide; D013835:Thiamine Pyrophosphate; D013831:Thiamine
O mekhanizme deĭstviia ékzogennykh vitamina B1, tiaminpirofosfata i FAD na gladkomyshechnye kletki.