title: Urethral denervation supersensitivity to noradrenaline after radical hysterectomy.
abstract: Urethral closure pressure profiles were registered before and during intravenous infusion of noradrenaline in 7 female patients who had undergone radical hysterectomy, and in whom a bladder denervation supersensitivity test to carbachol previously had been positive. Patients who had a completely denervated bladder had a greater rise in maximum urethral pressure during noradrenaline infusion (exceeding 20 cm H2O) than normal subjects (1 to 15 cm H2O). Urethral supersensitivity to noradrenaline may be a promising test in diagnosing damage of the sympathetic nervous innervation of the lower urinary tract.
mesh_terms: D000328:Adult; D003714:Denervation; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000494:pharmacology*; D011312:Pressure; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014521:Urethra / Q000187:drug effects* / Q000503:physiopathology; D001743:Urinary Bladder / Q000294:innervation; D001750:Urinary Bladder, Neurogenic / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology
chemical_list: D009638:Norepinephrine