[Interaction of the three alkylating drugs, cyclophosphamide, ifosfamide and trofosfamide, with DNA and DNA-constituents in vitro (author's transl)].
In vitro experiments were done for investigating the interactions of the three 3H-labelled alkylating drugs cyclophosphamide, ifosfamide and trofosfamide with DNA and DNA-constituents. Evidence is presented for a preferred reaction with orthophosphate groups, leading to phosphotriesters in the DNA. The results are discussed in view of the chemotherapeutic action of the drugs their mutagenic or carcinogenic effects.
D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D003520:Cyclophosphamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D004261:DNA Replication / Q000187:drug effects*; D003853:Deoxyribonucleosides / Q000378:metabolism; D005260:Female; D007069:Ifosfamide / Q000494:pharmacology; D008862:Microsomes, Liver / Q000187:drug effects; D051381:Rats
D000477:Alkylating Agents; D003853:Deoxyribonucleosides; D003520:Cyclophosphamide; C003726:trofosfamide; D007069:Ifosfamide
In-vitro-Reaktion der drei alkylierenden Pharmaka Cyclophosphamid, Ifosfamid und Trofosfamid mit DNS und DNS-Bausteinen.