[BCG-infection in chronic granulomatous disease (author's transl)].
A 7 year old boy developed in the newborn period a chronic suppurative process after routine BCG vaccination beginning at the site of the injection and spreading to the adjacent areas on neck and chin. A supraclavicular lymphadenopathy was also noted. Serial histological examinations revealed the typical histopathological pattern of tuberculosis and the boy received a tuberculostatic therapy for five years. During this time he suffered from multiple chronic bacterial infections which led to chronic granulomatous inflammations in different organs and to a fibrous pneumonitis with subsequent cor pulmonale. At the age of 6 years a negative NBT-test allowed the diagnosis of GCD. Consequently therapy with Sulfamethoxazol-Trimethoprim was started and the rate of infections diminished markedly.
D001500:BCG Vaccine / Q000009:adverse effects*; D001706:Biopsy; D002648:Child; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000473:pathology; D006801:Humans; D008197:Lymph Node Excision; D008199:Lymphadenitis / Q000150:complications; D008297:Male; D011658:Pulmonary Fibrosis / Q000150:complications; D011660:Pulmonary Heart Disease / Q000150:complications; D014388:Tuberculosis, Lymph Node / Q000150:complications / Q000473:pathology
D001500:BCG Vaccine
BCG-Impfkomplikation bei septischer Granulomatose.