Equine leucocyte antigen system. III. Non-MHC linked alloantigenic system in horses.
A new, non-MHC linked alloantigenic membrane antigen on the equine lymphocytes is described. This antigen was characterized with alloantisera in the two-stage microcytotoxicity test and designated as ELy-1 antigen. The frequency of ELy-1 antigen positive animals in various populations is close to 50%. ELy-1 shows an autosomal, dominant inheritance. Since an allelic antigen (s) could not be demonstrated in family studies, it is assumed that only two alleles ELy-1+ and ELy-1- exist. The ELy-1 antigen in positive animals is expressed on both T and B lymphocytes but it is not present on erythrocytes and thrombocytes. The incidence of ELy-1 antigen positive animals is significantly higher in horse groups suffering from chronic bronchitis or from laminitis, compared to clinically healthy controls.
D000818:Animals; D000950:Antigens, Ly / Q000235:genetics; D000954:Antigens, Surface / Q000235:genetics*; D001991:Bronchitis / Q000276:immunology / Q000662:veterinary; D005534:Foot Diseases / Q000276:immunology / Q000662:veterinary; D008040:Genetic Linkage; D006724:Hoof and Claw; D006734:Horse Diseases / Q000276:immunology; D006736:Horses / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology*; D008285:Major Histocompatibility Complex
D000950:Antigens, Ly; D000954:Antigens, Surface