title: Anti-C-carbohydrate antibodies after pneumococcal vaccination.
abstract: Similar levels of naturally occurring anti-pneumococcal C-carbohydrate antibodies were found in 15 splenectomized children, 10 splenectomized adults and 12 healthy adult volunteers by enzymelinked immunosorbent assay. Vaccination with a 14-valent pneumococcal capsular polysaccharide vaccine (Pneumovax) that contains approximately 75 micrograms C-carbohydrate per dose only led to small anti-C-carbohydrate antibody increases; they were significant, however, for all three groups (p less than 0.05) but antibody fold increases were below 2 in 34 of the 37 individuals studied.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008875:Middle Aged; D022242:Pneumococcal Vaccines; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D014611:Vaccination
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D022242:Pneumococcal Vaccines; D011135:Polysaccharides, Bacterial; C027158:polysaccharide C-substance (Streptococcus)