Seizures and transient cortical blindness associated with cis-platinum (II) diamminedichloride (PDD) therapy in a thirty-year-old man.
Cis-Platinum is a phase II chemotherapeutic agent effective against a variety of tumors. Known toxic effects include gastrointestinal, renal, audiologic, and hematologic as well as idiosyncratic and atopic. A 30-year-old male who was treated with cis-Platinum diamminedichloride II for disseminated embryonal cell carcinoma of the testicle developed seizures and cortical blindness.
D000328:Adult; D001766:Blindness / Q000139:chemically induced*; D002945:Cisplatin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010984:Platinum / Q000097:blood / Q000134:cerebrospinal fluid; D012640:Seizures / Q000139:chemically induced*; D013724:Teratoma / Q000188:drug therapy / Q000378:metabolism; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000378:metabolism; D013997:Time Factors
D010984:Platinum; D002945:Cisplatin