[Detection of lymphocytotoxic HLA-A, B, C antibodies in the blood of married female blood donors. II. Population study of the relation between: a) the number of immunizing events and the presence of antibodies; b) time elapsed and presence of antibodies].
Sera of 1.843 blood donors married women of the Turin population have been checked against random lymphocytes samples of the same population according to NIH standard technique. Positive (with cytotoxic antibodies) and negative (without cytotoxic antibodies) women have been, separately, distributed in classes: A) events number classes and B) time classes. "A-type" distributions were dealing with number of deliveries and, separately, with total number of immunizing events (deliveries, abortions, received blood transfusions); "B-type" distributions were dealing with number of years passed from last delivery to bleeding and, separately, from last immunizing event to bleeding. Differences between positive and negative women distributions were not significant. Number of events and time elapsed after last event do not affect presence or absence of antibodies significantly. Genetic individual constitution seems to affect not only presence or absence of antibodies, but also the duration of response.
D000017:ABO Blood-Group System; D000022:Abortion, Spontaneous; D000328:Adult; D000367:Age Factors; D000961:Antilymphocyte Serum / Q000032:analysis*; D001782:Blood Donors; D001803:Blood Transfusion; D003165:Complement System Proteins; D036861:Delivery, Obstetric; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D007518:Isoantibodies / Q000032:analysis*; D008875:Middle Aged; D010298:Parity; D011247:Pregnancy; D013997:Time Factors
D000017:ABO Blood-Group System; D000961:Antilymphocyte Serum; D006680:HLA Antigens; D007518:Isoantibodies; D003165:Complement System Proteins
Ricerca di anticorpi HLA-A, -B, -C linfocitotossici nel siero di donatrici di sangue coniugate. II. Studio popolazionistico della relazione tra : 1) il numero di eventi immunizzanti e la presenza di anticorpi; b) il tempo trascorso e la presenza di anticorpi.