title: The influence of esterification on the topical antiinflammatory activity of 7 alpha-chloro- and 7 alpha-bromo-16 alpha-methylprednisolones.
abstract: The effect on topical antiinflammatory potency of altering the ester functions of 7-halogenocorticosteroids was examined. Highest potencies for both 7 alpha-chloro- and 7 alpha-bromo-16 alpha-methylprednisolones were generally achieved through diesterification at the 17- and 21-positions. However, among these diesters, structure seems to be more important for topical potency than lipophilicity.
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D004952:Esters; D005938:Glucocorticoids; D008775:Methylprednisolone / Q000031:analogs & derivatives*; D051379:Mice; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D004952:Esters; D005938:Glucocorticoids; D008775:Methylprednisolone