[The influence of clofibrate on elevated serum lactate levels in diabetic patients treated with biguanides (author's transl)].
The increments in serum lactate and ketone bodies induced by biguanides in 11 diabetics were decreased by a combined treatment with clofibrate and phenformin. Lactate concentration was nearly the same on a placebo or on the combined drug treatment. While-body weight reduction in subjects was without influence on the clofibrate-induced lowering of lactate it inhibited a decrease of ketone bodies. The effect of clofibrate on lactate was directly correlated to its serum triglyceride lowering effect. The decrease in lactate points to an improved lactate utilization. A combined clofibrate-biguanide treatment is only indicated in selected patients, predominantly in diabetics with endogenous hypertriglyceridemia, however, contraindications of both drugs have to be observed.
D000328:Adult; D001645:Biguanides / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D002994:Clofibrate / Q000494:pharmacology*; D003920:Diabetes Mellitus / Q000097:blood* / Q000188:drug therapy; D004798:Enzymes / Q000097:blood; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007773:Lactates / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010629:Phenformin / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood
D001645:Biguanides; D004798:Enzymes; D007004:Hypoglycemic Agents; D007773:Lactates; D008055:Lipids; D014280:Triglycerides; D010629:Phenformin; D002994:Clofibrate
Der Einfluss von Clofibrat auf erhöhte Serumlaktatspiegel bei mit Biguaniden behandelten Diabetikern.