Cyclo (His-Pro): mapping hypothalamic sites for its hypothermic action.
Hypothalamic loci of Sprague-Dawley rats were individually injected with cyclo (His-Pro) to determine the sites where that metabolite of thyrotropin-releasing hormone acts to produce hypothermia. There was almost always a positive hypothermic response in the preoptic-anterior hypothalamic area (POA/AHA); injection into the posterior or middle hypothalamic areas or into the hippocampus caused no significant decrease in core temperature. The fact that only injection into the POA/AHA evoked hypothermia suggests that this area is a major hypothalamic site of action of cyclo (His-Pro) in modulating thermoregulation in the rat.
D000818:Animals; D007025:Anterior Hypothalamic Nucleus / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects*; D001931:Brain Mapping; D007031:Hypothalamus / Q000187:drug effects*; D007033:Hypothalamus, Middle / Q000187:drug effects; D007034:Hypothalamus, Posterior / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D010456:Peptides, Cyclic / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011301:Preoptic Area / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D010456:Peptides, Cyclic; D010879:Piperazines; C015924:histidyl-proline diketopiperazine