Kyrle's disease. Response to high-dose vitamin A.
A 60-year-old man with a twelve-year history of Kyrle's disease is presented. Twice during this period, hospitalization and a variety of topical and systemic medications had resulted in little improvement. Recently, following the confirmation of the diagnosis, megadose vitamin A orally resulted in the resolution of most of the lesions. The amount of vitamin A was gradually reduced, and therapy was continued with a combination of vitamin A and vitamin E (dl-alpha-tocopheryl acetate).
D000284:Administration, Oral; D007644:Darier Disease / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008875:Middle Aged; D014801:Vitamin A / Q000008:administration & dosage* / Q000627:therapeutic use; D014810:Vitamin E / Q000627:therapeutic use
D014801:Vitamin A; D014810:Vitamin E