[Sensitization of male rats to aggressive behavior by apomorphine].
In experiments on male Wistar rats it was established that following a 10 days treatment with low doses (0.1 mg/kg) of apomorphine, tolerance developed to its sedative effects, while aggression to foot-shocks was markedly enhanced. Administration of apomorphine (0.5 mg/kg) and amphetamine (2.5 mg/kg) after chronic low dose apomorphine treatment revealed an enhancement of their effects - stereotypy and aggressiveness was observed. Nalorphine, blockader of opiate receptors, after sensibilization of male rats with apomorphine also caused an increase of aggression to foot-shocks. Nalorphine antagonized, as low doses of apomorphine did, antiaggressive action of morphine. It is suggested that long-lasting treatment with apomorphine enhances the sensitivity of dopamine receptors to agonists, and of opiate receptors to antagonists. These changes on synaptic level are possibly involved in the phenomenon of apomorphine hyperaggressiveness.
D000374:Aggression / Q000187:drug effects*; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000494:pharmacology*; D002395:Catecholamines / Q000032:analysis; D003342:Corpus Striatum / Q000032:analysis; D006801:Humans; D008032:Limbic System / Q000032:analysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects; D013268:Stimulation, Chemical
D002395:Catecholamines; D000661:Amphetamine; D001058:Apomorphine
Sensibilizatsiia apomorfinom krys-samtsov k aggressivnomu povedeniiu.