[Isoniacid intoxication: correlation between blood level and coagulation status? (author's transl)].
In a 1,10 year old boy intoxication by isoniazid (INH) produced an initial fall of prothrombin and a prolonged fall of the clotting factor VII. The rest of the coagulation factors as well as the inhibitor activity remained uninfluenced. Since the decrease of the liver-dependent clotting factors occurred immediately after ingestion the apparently rare INH induced liver injury is considered as dose-dependent. On the other hand, however, since the serum half-life of INH amounted to 2,98 hours whereas the decrease of factor VII persisted over 46 hours and there appears to be no correlation between liver injury and INH plasma levels. This discrepancy may be attributable to the fact that only the acetylated intermediates of INH may have a hepatotoxic potential.
D001778:Blood Coagulation Disorders / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D005167:Factor VII / Q000032:analysis; D006207:Half-Life; D006801:Humans; D007223:Infant; D007538:Isoniazid / Q000097:blood / Q000378:metabolism / Q000506:poisoning*; D008297:Male; D011516:Prothrombin / Q000032:analysis
D005167:Factor VII; D011516:Prothrombin; D007538:Isoniazid
Isoniacid (INH) Intoxikation: Beziehung zwischen Blutspiegel und Gerinnungsstörungen?