Inhibition of human bone marrow-granulocyte precursors by serum from patients with Felty's syndrome.
Eight of 19 patients with Felty's syndrome were shown to have a serum factor capable of inhibiting in vitro colony formation by human bone marrow-granulocyte precursors. These data raise the possibility that a serum factor may play a role in the induction of leukopenia in Felty's syndrome.
D000961:Antilymphocyte Serum / Q000494:pharmacology; D001854:Bone Marrow Cells; D003114:Colony-Forming Units Assay; D003165:Complement System Proteins; D005258:Felty Syndrome / Q000097:blood*; D006098:Granulocytes / Q000166:cytology*; D006801:Humans; D008264:Macrophages / Q000166:cytology; D011696:Purpura, Thrombocytopenic / Q000097:blood; D013156:Splenectomy
D000961:Antilymphocyte Serum; D003165:Complement System Proteins