title: Pseudotumor cerebri in an obese woman with Turner syndrome.
abstract: Extraovarian estrogen production was studied in an obese young woman with pathologically confirmed mosaic Turner syndrome and pseudotumor cerebri. Diet plus enough dexamethasone to suppress adrenal steroidogenesis promptly lowered cerebrospinal fluid testosterone. Estrone was detected in cerebrospinal fluid before and after but not during dexamethasone treatment. Extraovarian estrogen probably produces the menstrual irregularities of obese young women with pseudotumor cerebri and may be involved in the pathogenesis of that syndrome.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000735:Androstenedione / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism; D004970:Estrone / Q000134:cerebrospinal fluid / Q000378:metabolism; D005260:Female; D006801:Humans; D008598:Menstruation; D009765:Obesity / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D011559:Pseudotumor Cerebri / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D014424:Turner Syndrome / Q000150:complications
chemical_list: D000305:Adrenal Cortex Hormones; D004967:Estrogens; D004970:Estrone; D000735:Androstenedione