title: Gastric or coeliac vagotomy decreases drinking after peripheral angiotensin II.
abstract: After bilateral subdiaphragmatic vagotomy, rats drank later and less in response to peripherally administered angiotensin II [13]. We attempted to localize this deficit neurologically by performing selective gastric, hepatic or coeliac vagotomies. The drinking responses of such selectively lesioned rats to 0.1 and 1.0 mg X kg-1 angiotensin II (SC) were compared to those of total bilateral vagotomized rats and sham vagotomized rats. Gastric or coeliac vagotomy produced drinking deficits that were similar to those produced by total abdominal vagotomy, but hepatic vagotomy did not. These results demonstrate the importance of abdominal vagal mechanisms in the drinking response to circulating angiotensin II.
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002447:Celiac Plexus / Q000502:physiology*; D004326:Drinking / Q000187:drug effects*; D008099:Liver / Q000294:innervation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000502:physiology; D013270:Stomach / Q000294:innervation*; D014630:Vagus Nerve / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000187:drug effects*
chemical_list: D000804:Angiotensin II