Effect of dilazep on shape change of human erythrocyte in blood stored over a period of 42 days.
The influence of addition of 1,4-[3,4,5-trimethoxybenzoyl-oxy)-propyl]-perhydro-1,4-diazepine dihydrochloride monohydrate (dilazep) on shape change of erythrocyte that had been stored in CPD-solution for 3--42 days at 4 degrees C, was studied by the use of a scanning electron microscope. The results obtained are as follows: 1. The discocyte-echinocyte transformation of erythrocyte occurred in blood stored at 4 degrees C for more than 3 days (cold-stored blood). 2. Dilazep (25 and 50 mumol/l) had no remarkable effect on the discocyte-echinocyte transformation of erythrocyte in the cold-stored blood). 3. Dilazep (100--500 mumol/l) slowed down the appearance of echinocyte and inhibited the transformation of erythrocyte in the cold-stored blood.
D001381:Azepines / Q000494:pharmacology*; D001793:Blood Preservation; D004109:Dilazep / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000648:ultrastructure*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D013997:Time Factors
D001381:Azepines; D004109:Dilazep