title: Rat brain 3-hydroxy-3-methylglutaryl-CoA reductase: subcellular distribution and cold lability.
abstract: Data are provided indicating that the rat brain 3-hydroxy-3-methylglutarhyl-CoA reductase is similar to the enzyme from other tissues as far as diurnal rythmicity, cold lability and half-life measurements of 0 degrees C are concerned. The enzyme activity in the brain decreased with age of the animals. Subcellular fractionation studies demonstrate that while 77% of the activity was associated with the microsomal fraction, 19% of the enzyme activity was recovered in the mitochondrial fraction. The possible function of such a mitochondrially located 3-hydroxy-3-methylglutaryl-CoA reductase in rat brain is discussed.
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology*; D002940:Circadian Rhythm; D003080:Cold Temperature; D005260:Female; D006903:Hydroxymethylglutaryl CoA Reductases / Q000032:analysis*; D025782:Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; D008297:Male; D008861:Microsomes / Q000201:enzymology; D008928:Mitochondria / Q000201:enzymology; D051381:Rats; D013347:Subcellular Fractions / Q000201:enzymology
chemical_list: D006903:Hydroxymethylglutaryl CoA Reductases; D025782:Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent