title: [Effect of vitamin A on immunological status of patients with chronic pneumonia].
abstract: Effect of vitamin A on some patterns of specific and unspecific immunity was studied in patients with chronic pneumonia. The vitamin was administered into the patients during 7 days at a daily dose of 500,000 IU. Administration of vitamin A was found to stimulate several immunological patterns: content of T- and B lymphocytes in peripheral circulation as well as IgG and IgM blood serum were increased. After the vitamin A treatment the cellular immunity was also stimulated, involving the activation of lymphocyte blast transformation with PHA and the increase in exhibition of skin reaction towards PHA. In response to vitamin A administration activation was observed of unspecific bactericidal, and complement activities in blood serum as well as of the myeloperoxidase activity in leukocytes of peripheral circulation. Administration of vitamin A into the control patients within a week at a daily dose of 10,000 IU did not alter the immunological patterns studied.
mesh_terms: D000917:Antibody Formation / Q000187:drug effects; D001770:Blood Bactericidal Activity / Q000187:drug effects; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D011014:Pneumonia / Q000276:immunology*; D014801:Vitamin A / Q000494:pharmacology*
chemical_list: D014801:Vitamin A
vernacular_title: Vliianie vitamina A na sostoianie immuniteta pri khronicheskoĭ pnevmonii.