title: Multiple endocrine neoplasia type 2b in twins.
abstract: The syndrome of multiple endocrine neoplasia (MEN or MEA) type 2b is characterized by the association of medullary carcinoma of the thyroid, phaeochromocytoma, ganglioneuromatosis and Marfan-like features. Though this disorder usually shows a familial distribution, it may also appear spontaneously as the result of a genetic mutation. This paper describes the second case of MEA type 2 in twins, and appears to be the first description in twins of the association of medullary carcinoma of the thyroid, Marfan-like features and multiple neuromas.
mesh_terms: D000293:Adolescent; D000328:Adult; D002277:Carcinoma / Q000235:genetics / Q000473:pathology*; D004700:Endocrine System Diseases / Q000473:pathology*; D005260:Female; D005729:Ganglioneuroma / Q000473:pathology; D006801:Humans; D008297:Male; D008382:Marfan Syndrome / Q000473:pathology; D010673:Pheochromocytoma / Q000473:pathology; D011247:Pregnancy; D013577:Syndrome; D013964:Thyroid Neoplasms / Q000235:genetics / Q000473:pathology*; D014430:Twins, Monozygotic