A rapid method of evaluate acute ethanol intoxication in mice.
A simple technique for the evaluation of ethanol intoxication based on the ability of mice to remain on a bar suspended above an electrified grid is reported. The characteristics that make this model useful to measure ethanol induced intoxication include: (a) low variability; (b) high sensitivity; (c) rapidity; (d) requires no previous training of animals to be tested; (e) objective scoring which can be quantified; and (f) dose-dependent correlation between brain and blood ethanol levels and bar holding response.
D000435:Alcoholic Intoxication; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D000431:Ethanol / Q000097:blood; D006801:Humans; D051379:Mice; D008813:Mice, Inbred ICR; D013997:Time Factors
D000431:Ethanol