[Influence of the intracaudate administration of kainic acid on the effects of the prolonged use of haloperidol and apomorphine on rats].
In rats injected with kainic acid into the dorsal part of the caudate nucleus, the chronic treatment (for 20 days) with haloperidol (1 mg/kg) did not induce hypersensitivity of dopamine receptors. However, kainic acid produced no effect on hypersensitivity of the receptors after long-term administration of apomorphine (1 mg/kg). It is suggested that in the CNS there exist at least two types of dopamine receptors one of which is involved in the hypersensitivity mechanism after long-term administration of neuroleptics (post-synaptic receptors), while another one in the hypersensitivity to the effects of long-term administration of dopaminomimetics (presynaptic receptors).
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D002375:Catalepsy / Q000139:chemically induced; D002421:Caudate Nucleus; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D007608:Kainic Acid / Q000008:administration & dosage*; D008297:Male; D011759:Pyrrolidines / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors
D011759:Pyrrolidines; D011954:Receptors, Dopamine; D006220:Haloperidol; D001058:Apomorphine; D007608:Kainic Acid
Vliianie vnutrikaudatnogo vvedeniia kainovoĭ kisloty na éffekty dlitel'nogo primeneniia galoperidola i apomorfina u krys.