Low serotonin uptake by platelets in leprosy and a new approach to prevent it.
The plasma of leprosy patients contains high levels of mucoproteins which are deficient in sialic acid. However, due to the increased mucoprotein level, the total sialic acid content of leprous plasma, calculated on protein, is increased when compared with normal human plasma. The low serotonin uptake observed with isolated platelets is probably due to their low sialic acid content. The inability of normal human plasma to correct the diminished serotonin uptake by isolated leprous platelets is in favor of a definite structural change in leprous platelets, related to their low sialic acid content. In patients with active disease and in those with lepra reactions, leprous plasma itself can correct the diminished uptake of serotonin by the isolated platelets. In patients with subsided lepra reactions, the leprous plasma is much less effective. In severe cases, where serotonin uptake is decreased even in platelet rich plasma, desoxyfructo-serotonin increased the uptake of serotonin.
D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D005632:Fructose / Q000031:analogs & derivatives / Q000494:pharmacology; D006801:Humans; D007918:Leprosy / Q000097:blood* / Q000378:metabolism; D009088:Mucoproteins / Q000097:blood; D012701:Serotonin / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D012794:Sialic Acids / Q000097:blood
D009088:Mucoproteins; D012794:Sialic Acids; D005632:Fructose; D012701:Serotonin; C018901:desoxyfructo-serotonin