title: A swine dysentery model for evaluation of drug prophylaxis: development of a model involving oral infection plus pen contamination.
abstract: To overcome some of the inadequacies of the classic artificial swine dysentery (SD) model that is frequently used to judge the efficacy of drugs in preventing SD, a model has been developed that produces SD comparable with natural infections that are frequently encountered in commercial pig production facilities. The model is a combination of a single oral infection (OI) plus pen contamination (PC), conducted each night for 25 nights. Results with OI alone, PC alone, and OI + PC have been compared, and the new model (OI + PC) produced consistent, homogeneous, and severe SD with 100% morbidity and 92% mortality.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004403:Dysentery / Q000209:etiology / Q000635:transmission / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000209:etiology* / Q000635:transmission