Effect of calcium antagonist, etafenone hydrochloride, on the isolated guinea pig tracheal tissues.
The present investigation was conducted to study the effect of 2'-[2-(diethylamino)ethoxy]-3-phenylpropiophenone hydrochloride (etafenone hydrochloride) on the action of various bronchoactive agents using isolated guinea pig tracheal tissues. Acetylcholine hydrochloride, prostaglandin F2a, histamine dihydrochloride and serotonin-creatinine sulfate induced contractile responses in guinea pig tracheal tissues were attenuated, while, isoprenaline hydrochloride, prostaglandin E2, salbutamol hemisulfate, aminophylline and adrenaline-induced relaxing responses were potentiated with continuous infusion of etafenone hydrochloride. These results suggest that etafenone hydrochloride would become a useful therapeutic agent in the treatment of chronic obstructive pulmonary disease.
D000403:Airway Resistance / Q000187:drug effects*; D000818:Animals; D002118:Calcium / Q000037:antagonists & inhibitors*; D004347:Drug Interactions; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011405:Propafenone / Q000031:analogs & derivatives*; D011427:Propiophenones / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects
D011427:Propiophenones; C001162:etafenone; D011405:Propafenone; D002118:Calcium