The effects of an adhesive in the middle ear.
This study investigated the effects of enbucrilate (Histoacryl) on the middle ear. Small amounts of the adhesive were used in 81 middle-ear operations performed on 50 rabbits. Light microscopic investigation of these ears 1, 2, and 3 months after surgery showed bone necrosis and a granulation tissue reaction surrounded by foreign-body giant cells. Inner-ear changes were observed in a third of the cases. Therefore, enbucrilate should only be used with extreme care and in minute quantities and never near the labyrinthine capsule.
D000818:Animals; D004429:Ear Ossicles / Q000187:drug effects; D004432:Ear, Middle / Q000187:drug effects*; D004659:Enbucrilate / Q000009:adverse effects*; D007249:Inflammation / Q000139:chemically induced; D010020:Osteonecrosis / Q000139:chemically induced; D011817:Rabbits
D004659:Enbucrilate