Platinosomes produced in cultured cells by platinum coordination complexes.
Cells in culture were exposed to cis-dichlorodiammineplatinum (II) and platinum-uracil blue. No platinum could be demonstrated in an intracellular location morphologically or by electron-probe x-ray analysis in the case of the former compound. However, platinum was readily demonstrated in phagosomes or phagolysosomes after exposure of cells to platinum-uracil blue.
D002460:Cell Line; D002945:Cisplatin / Q000378:metabolism*; D004577:Electron Probe Microanalysis; D006367:HeLa Cells; D006801:Humans; D008247:Lysosomes / Q000032:analysis / Q000378:metabolism* / Q000648:ultrastructure; D008928:Mitochondria / Q000648:ultrastructure; D009944:Organoplatinum Compounds / Q000378:metabolism*; D010587:Phagocytosis; D010984:Platinum / Q000032:analysis / Q000378:metabolism*; D014498:Uracil / Q000031:analogs & derivatives* / Q000378:metabolism
D009944:Organoplatinum Compounds; D010984:Platinum; D014498:Uracil; C011996:platinum uracil blue; D002945:Cisplatin