Stimulation of non-specific resistance and specific immune response against tumours in mice by synthetic muramyl dipeptide.
Synthetic MDP administered in an aqueous medium at relatively high doses stimulates non-specific and specific tumour immunity. Non-specific inhibition of tumour growth was observed in B10 mice injected with 1 mg of MDP 14 days before transplantation of 3-Mc-induced sarcoma cells. Muramyl dipeptide in an aqueous medium increases specific tumour immunity when injected in the dose of 1 mg per mouse together with irradiated tumour cells.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000627:therapeutic use*; D000818:Animals; D004351:Drug Resistance; D005260:Female; D005354:Fibrosarcoma / Q000188:drug therapy* / Q000276:immunology; D007109:Immunity; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000188:drug therapy* / Q000276:immunology
D000119:Acetylmuramyl-Alanyl-Isoglutamine