Effects of flurazepam and diazepam in isolated guinea-pig taenia coli and longitudinal muscle.
The effects of the benzodiazepine derivatives flurazepam and diazepam on K+- and Ca2+ -induced contracture were examined in isolated taenia coli and longitudinal muscle of the guinea-pig. Flurazepam and diazepam inhibited the tonic component more than the phasic component of the K+ -induced contracture of taenia coli. In longitudinal muscle, both flurazepam and diazepam inhibited the Ca2+ -induced contracture dose-dependently. These findings suggest that the observed effects of flurazepam and diazepam may have been due to inhibition of the transmembrane influx of Ca2+.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002432:Cecum / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D005479:Flurazepam / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D011188:Potassium / Q000494:pharmacology
D005479:Flurazepam; D003975:Diazepam; D011188:Potassium; D002118:Calcium