title: [Effect of alcohol on serum thyrotropin concentration of rats predisposed and unpredisposed to alcohol].
abstract: It has been shown that alcohol-motivated Wistar female rats after 10 days of repeated ethanol administration have a decreased cold- or TRH-stimulated TSH level in the blood serum under physical dependence and abstinence. There were no changes of TSH secretion in animals non-motivated to alcohol. Acetaldehyde inhibited significantly the TSH cold-response but did not influence the TRH-induced TSH secretion. It is suggested that repeated ethanol administration causes hypofunction of both hypothalamic TRH neurons and anterior pituitary thyrotropic cells. Partially it may depend on acetaldehyde inhibitory action on the hypothalamic level of regulation of thyroid gland functioning.
mesh_terms: D000079:Acetaldehyde / Q000494:pharmacology; D000437:Alcoholism / Q000097:blood*; D000818:Animals; D001921:Brain / Q000503:physiopathology; D003080:Cold Temperature; D004198:Disease Susceptibility; D004298:Dopamine / Q000502:physiology; D005260:Female; D006801:Humans; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome / Q000097:blood*; D013972:Thyrotropin / Q000097:blood*
chemical_list: D013972:Thyrotropin; D000079:Acetaldehyde; D004298:Dopamine
vernacular_title: Vliianie alkogolia na soderzhanie tirotropina v syvorotke krovi krys, predraspolozhennykh i ne predraspolozhennykh k alkogoliu.