Cushing's disease presenting as amenorrhoea with hyperprolactinaemia: report of two cases.
Two patients with Cushing's disease first presented with amenorrhoea, hyperprolactinaemia, and normal tomograms of the sella turcica. Both women underwent trans-sphenoidal removal of a pituitary microadenoma resulting in a decreased serum prolactin concentration in both, and cessation of galactorrhoea and return of menses in one of them. One woman became ACTH deficient while the other has persistent Cushing's disease. A survey of the literature on Cushing's disease and prolactinomas shows the association to be uncommon. A likely mechanism is secretion of both hormones by the microadenomas. These two patients illustrate the need for screening other pituitary hormone function in patients with hyperprolactinaemia.
D000236:Adenoma / Q000150:complications; D000328:Adult; D000568:Amenorrhea / Q000209:etiology*; D003480:Cushing Syndrome / Q000150:complications / Q000175:diagnosis*; D005260:Female; D005687:Galactorrhea / Q000209:etiology; D006801:Humans; D010911:Pituitary Neoplasms / Q000150:complications; D011247:Pregnancy; D011388:Prolactin / Q000097:blood*
D011388:Prolactin