[The diuretic activity of bumetanide in a controlled comparison with furosemide in patients with various degrees of impaired renal function (author's transl)].
The effect of bumetanide (6 and 12 mg) was compared with that of furosemide (250 and 500 mg) in 13 patients with chronic renal insufficiency in a double-blind study using each patient as his own control. In the dose ratio of 1:40 previously obtained in normal subjects furosemide showed a significantly higher diuretic response than bumetanide. Comparing the relative natriuretic effects in chronic renal insufficiency a ratio of 1:10 to 1:12 (B:F) seemed to be adequate. More than 12 mg bumetanide cannot be recommended because of the severe muscle pains which occurred in all patients with that dosage.
D000328:Adult; D002034:Bumetanide / Q000494:pharmacology*; D003404:Creatinine / Q000097:blood; D004231:Diuresis / Q000187:drug effects*; D004232:Diuretics / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects
D004232:Diuretics; D002034:Bumetanide; D005665:Furosemide; D003404:Creatinine
Die diuretische Effektivität von Bumetanid im kontrollierten Vergleich zu Furosemid bei chronischer Niereninsuffizienz unterschiedlichen Schweregrades.