[Antineoplastic effect of modified pelvic vascular bed isolation chemotherapy and increased survival in patients with radioresistant cervical cancer of stage II b and above].
Poorly radiorespondent and upanhysterectomized 10 cervical cancer patients, 2 being Stage IIb, 6 Stage III and 2 Stage IV, underwent a modified pelvic vascular bed isolation chemotherapy with one shot infusion of 50mg to 70mg of mitomycin C: into the internal iliac arteries. In 9 cases out of 10 thus treated, cytological, histological and macroscopic examinations failed to detect local malignancy after the isolation chemotherapy. However, there was a notable time difference in disappearing their local malignancies. Namely, 5 cases needed less than 15 hours to expel their cytological local malignancies, while the other 4 cases needed 4 days or more, average 13 days. Two cases needed less than 15 hours to eliminate their histological local malignancies, while the other 7 cases 3 days or more, average 10 days. Only 5 patients whose cytological malignancy disappeared within 15 hours are now all alive without apparent disease since the past 10 months or more, average 31 months. On the other hand, 4 patients who needed 4 days or more and 1 patient whose local malignancy was maintained even one month after the isolation chemotherapy were all dead with average survival period of 7.6 months in spite of the additionally performed excision surgery. It is concluded here that the modified isolation chemotherapy will be able to eradicate almost all evidences of local malignancies, no matter how obstinately the tumor resists to radiotherapy. However, cytological evidence of local malignancy ought to be eliminated within 15 hours in order to ensure elongation of patient's survival period.
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000401:mortality
D000970:Antineoplastic Agents