(+/-)-1-(Adamantan-2-yl)-2-propanamine and other amines derived from 2-adamantanone.
The synthesis of (+/-)-1-(adamantan-2-yl)-2-propanamine (VI), its N,N-dimethyl derivative (VII) and other amines (VIII), (IX) and (X), starting from 2-adamantanone, is described. Some of these amines showed antiparkinson activity in mice.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000978:Antiparkinson Agents / Q000138:chemical synthesis*; D002375:Catalepsy / Q000517:prevention & control; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011247:Pregnancy; D014202:Tremor / Q000517:prevention & control
D000978:Antiparkinson Agents; C028228:N,N-dimethyl-1-(adamantan-2-yl)-2-propanamine; C028227:1-(adamantan-2-yl)-2-propanamine; D000109:Acetylcholine; D000218:Adamantane; C001862:adamantanone