title: [The effect of midazolam on general hemodynamics and cerebral blood flow in animals and man (author's transl)].
abstract: 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a] [1,4]benzodiazepine (midazolam Ro 21-3981, Dormicum) has a number of useful properties--including good tolerance on i.v. injection, and short duration of action--which make it a valuable substance in anesthesiology. The present study deals in particular with the general, coronary and cerebral hemodynamics. Observed hemodynamic effects lasted no more than 10 min, which renders midazolam a drug of good controllability.
mesh_terms: D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008874:Midazolam
chemical_list: D000777:Anesthetics; D001569:Benzodiazepines; D008874:Midazolam
vernacular_title: Die Wirkung von Midazolam auf die allgemeine Hämodynamik und die Hirndurchblutung beim Tier und beim Menschen.