[Cytophotometric study of the progeny of clonogenic mouse rhabdomyosarcoma cells in lung tissue].
50 clones of murine rhabdomyosarcoma were grown in lungs, DNA contents of interphase nuclei of these clones being measured cytophotometrically. Significant differences in the mean DNA contents of clones obtained were observed, reflecting karyotypic differences of the initial clonogenic cells. The progenies of clonogenic cells had very high genome mutation rates (17.4 +/- 0.3.10(-2), and cells with increased numbers of chromosomes arose more frequently than hypoploid cells (12.5 +/- 0.3 and 2.9 +/- 0.2.10(-2), respectively). The mutability of tumor cells was non-equal in different clones, and positive correlations were observed between the mean DNA contents and mutability of the clones, whereas negative correlations were noticed between mutability and rates of cell proliferations.
D000818:Animals; D002999:Clone Cells; D003114:Colony-Forming Units Assay; D004273:DNA, Neoplasm / Q000378:metabolism*; D005260:Female; D006651:Histocytochemistry; D007621:Karyotyping; D008168:Lung; D051379:Mice; D008815:Mice, Inbred Strains; D009154:Mutation; D009374:Neoplasms, Experimental; D011003:Ploidies; D012208:Rhabdomyosarcoma / Q000235:genetics* / Q000378:metabolism
D004273:DNA, Neoplasm
Tsitofotometricheskoe izuchenie potomstv klonogennykh kletok rabdomiosarkomy myshi v legochnoĭ tkani.