title: 2-Bromo-1-hydroxyquinolizinium bromide substituted anilinium salts: a new class of anti-inflammatory agents.
abstract: A series of 2-bromo-1-hydroxyquinolizinium bromide substituted anilinium salts have been prepared by reaction of 1-acetoxy-2-bromoquinolizinium bromide with an appropriately substituted aniline. The resulting anilinium derivatives exhibited a moderate to high degree of anti-inflammatory activity in the carrageenin-induced rat paw edema assay. The most active anilinium salt of the series was evaluated for antiarthritic activity in the adjuvant induced arthritis rat model.
mesh_terms: D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D001169:Arthritis, Experimental / Q000188:drug therapy; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D011807:Quinolizines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000814:Aniline Compounds; D000893:Anti-Inflammatory Agents; D011807:Quinolizines