title: [Stevens-Johnson syndrome and toxic epidermal necrolysis following intake of sulfonamides].
abstract: Sulfonamides, particularly in combination with trimethoprim, are among the most commonly prescribed antimicrobial chemotherapeutic agents since they are generally well tolerated and have a broad antibacterial spectrum. However, they are the most common cause of adverse cutaneous drug reactions, the most serious of which are the major variant of erythema multiforme, i.e. Stevens-Johnson-syndrome, and toxic epidermal necrolysis. In eight of 11 patients with Stevens-Johnson syndrome or toxic epidermal necrolysis seen in our department over a period of 4 years, sulfonamides were the most probable causative agent. The present report describes these eight patients and discusses the potential risks of sulfonamide therapy.
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced* / Q000209:etiology* / Q000473:pathology; D013449:Sulfonamides / Q000009:adverse effects*
chemical_list: D013449:Sulfonamides
vernacular_title: Stevens-Johnson-Syndrom und toxische epidermale Nekrolyse nach Sulfonamideinnahme.