CArcinogenic activity of clivorine, a pyrrolizidine alkaloid isolated from Ligularia dentata.
The carcinogenic activity of clivorine, a pyrrolizidine alkaloid isolated from Ligularia dentata, was studied in inbred ACI rats. Twelve animals in the experimental group received a 0.005% solution of clivorine in drinking water for 340 days and survived beyond 440 days after the beginning of the experiment. Of this group, 8 developed tumors in the liver; 2 developed hemangioendothelial sarcomas, and 6 developed neoplastic nodules. The hemangioendothelial sarcoma showed metastasis in the lung of one rat. No tumors were observed in the liver of the control animals.
D000818:Animals; D002273:Carcinogens; D005260:Female; D006394:Hemangiosarcoma / Q000139:chemically induced* / Q000556:secondary; D008113:Liver Neoplasms / Q000139:chemically induced*; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D011763:Pyrrolizidine Alkaloids / Q000633:toxicity*; D051381:Rats
D002273:Carcinogens; D011763:Pyrrolizidine Alkaloids; C028677:clivorine