Inhibition of platelet aggregation by 1-alkylimidazole derivatives, thromboxane A synthetase inhibitors.
1-Alkylimidazole derivatives of various sidechain lengths with various functional groups at the terminal end of the alkylchain inhibited the synthesis of thromboxane A2 from arachidonic acid by rabbit platelets and the conversion of prostaglandin H2 to thromboxane A2 by the microsomes of rabbit platelets. These enzyme inhibitors were anti-aggregatory as examined with rabbit and human platelet-rich plasma under various experimental conditions.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D001792:Blood Platelets / Q000201:enzymology; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D008861:Microsomes / Q000201:enzymology; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D010974:Platelet Aggregation / Q000187:drug effects*; D011463:Prostaglandins H / Q000378:metabolism; D011817:Rabbits; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
D001095:Arachidonic Acids; D007093:Imidazoles; D011463:Prostaglandins H; D010088:Oxidoreductases; D013930:Thromboxane-A Synthase