Inhibition of sebaceous gland activity by spironolactone in Syrian hamster.
In the animal model of the Syrian hamster the antiandrogenic action of spironolactone on the sebaceous glands of the ventral side of the pinna was examined. Spironolactone reduces both labeling index and cross-sectional surface area of sebaceous glands significantly in a dose-dependent manner. Equally there was a significant decrease in serum testosterone levels in spironolactone treated animals. Our results seem to justify clinical studies with spironolactone in patients with hirsutism, seborrhea, and possibly acne vulgaris.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002940:Circadian Rhythm; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D008297:Male; D008647:Mesocricetus; D012627:Sebaceous Glands / Q000166:cytology / Q000187:drug effects*; D013148:Spironolactone / Q000008:administration & dosage / Q000494:pharmacology*; D013739:Testosterone / Q000037:antagonists & inhibitors / Q000097:blood
D013148:Spironolactone; D013739:Testosterone