The neurotoxicity and antifertility properties of 6-chloro-6-deoxyglucose in the mouse.
6-chloro-6-deoxyglucose (24 mg/kg/day) produces infertility in male rats and marmosets. In the present study very high doses (480 mg/kg/day) were found not to impair the fertility of male mice. However, such doses induced the formation of vacuolated lesions in specific regions of central nervous system grey matter causing varying degrees of physical disability. A similar response has been obtained in marmosets. Astrocytes appear to be primarily affected with later involvement of nerve cells. The sites of lesions correspond closely to regions of high glucose utilization.
D000818:Animals; D001253:Astrocytes / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects* / Q000473:pathology; D003272:Contraceptive Agents, Male / Q000633:toxicity*; D003837:Deoxy Sugars / Q000633:toxicity*; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism / Q000633:toxicity*; D005298:Fertility / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009410:Nerve Degeneration / Q000187:drug effects; D014617:Vacuoles / Q000473:pathology
D003272:Contraceptive Agents, Male; D003837:Deoxy Sugars; C021163:6-chloro-6-deoxyglucose; D003847:Deoxyglucose; D005947:Glucose