[The effect of sulfur compounds (N-acetylhomocysteine-thiolactone and penicillamine) on liver collagen metabolism in chronic thioacetamide poisoning].
The influence of N-acetyl-homocysteine-thiolactone (AHCT) and penicillamine on experimental thioacetamide (TAA)-induced liver fibrosis was investigated. TAA causes an increase in liver collagen content, which can partly be prevented by penicillamine and AHCT. This prevention is most effective, when the TAA-intoxication started earlier than the therapy with these two substances. The therapeutic effect of penicillamine is achieved by an inhibition of collagen biosynthesis and cross-linking (with an increase in the easily soluble collagen fractions). In the case of AHCT the inhibition of pathological collagen synthesis in experimental liver fibrosis cannot be explained by disturbed collagen cross-linking or increased collagen solubility. Whether collagen synthesis is inhibited and/or other influences of AHCT are present has still to be analyzed.
D000081:Acetamides / Q000506:poisoning*; D000818:Animals; D003094:Collagen / Q000096:biosynthesis / Q000378:metabolism*; D003545:Cysteine / Q000494:pharmacology; D006909:Hydroxyproline / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D010396:Penicillamine / Q000494:pharmacology*; D051381:Rats; D013853:Thioacetamide / Q000506:poisoning*; D013876:Thiophenes / Q000494:pharmacology*
D000081:Acetamides; D013876:Thiophenes; D013853:Thioacetamide; C000486:citiolone; D003094:Collagen; D010396:Penicillamine; D003545:Cysteine; D006909:Hydroxyproline
Der Einfluss von Thio-Verbindungen (N-Acetylhomocysteinthiolakton und Penicillamin) auf den Kollagenstoffwechsel der Leber bei chronischer Thioacetamid-Intoxikation.