Inhibition of RNA viruses in vitro and in Rift Valley fever-infected mice by didemnins A and B.
Didemnins, a new class of depsipeptides isolated from a Caribbean tunicate, have been shown to have potent antiviral activity against a broad range of RNA viruses in vitro. Didemnins A and B both protected mice against a lethal challenge of Rift Valley fever virus.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D047630:Depsipeptides; D005260:Female; D051379:Mice; D010456:Peptides, Cyclic / Q000494:pharmacology; D012328:RNA Viruses / Q000187:drug effects*; D012295:Rift Valley Fever / Q000188:drug therapy / Q000382:microbiology*; D010948:Viral Plaque Assay
D000998:Antiviral Agents; D047630:Depsipeptides; D010456:Peptides, Cyclic; C030051:didemnins