Consequences of modified fasting in obese pediatric and adolescent patients: effect of a carbohydrate-free diet on serum proteins.
Serum proteins were monitored during three studies of obese adolescents treated with protein-supplemented fasting in a clinical research center. In the first study of nine patients, small but significant decreases were noted for total serum protein, albumin, transferrin, retinol-binding protein, and complement beta 1c after 4 wk of carbohydrate-free protein-supplemented fast. In a further study of four of these same patients, the substitution of 400 glucose cal for 400 fat cal in a 5th wk of dietary study returned the total protein and retinol-binding protein concentrations to base-line levels. In a 3rd study of four patients, only complement beta 1c was significantly below base-line concentrations after 3 wk on a carbohydrate-containing protein-supplemented fast. There is an apparent metabolic effect of carbohydrate ingestion on maintaining usual concentrations of serum proteins.
D000293:Adolescent; D001798:Blood Proteins / Q000378:metabolism*; D002648:Child; D003165:Complement System Proteins / Q000097:blood; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D005215:Fasting; D005947:Glucose; D006801:Humans; D009765:Obesity / Q000097:blood / Q000178:diet therapy*; D012177:Retinol-Binding Proteins / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism
D001798:Blood Proteins; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D012177:Retinol-Binding Proteins; D012709:Serum Albumin; D014168:Transferrin; D003165:Complement System Proteins; D005947:Glucose