The effect of oral neomycin on the absorption of isoniazid, quinidine and sulphafurazole from the rat small intestine in situ.
The effect of oral neomycin (2 g/kg for 4 or 7 days) on drug absorption from the small intestine was studied in anaesthetized rats in situ. Neomycin did not greatly affect the small intestinal morphology. Only in some cases there were slightly edematous and low villi in the intestines of the rats treated for 7 days, and there was "nuclear debris" in the mucosal cells as a sign of neomycin toxicity. Neomycin did not modify isoniazid or quinidine absorption, nor did it have any effects on intestinal fluid absorption. Sulphafurazole absorption was retarded, but the change was significant only after a 7-day neomycin treatment. The mechanisms of neomycin-induced changes in absorption still remain largely speculative, but the findings support the concept of the rat being fairly resistant to oral neomycin with respect to eventual malabsorption.
D000818:Animals; D005260:Female; D006207:Half-Life; D007408:Intestinal Absorption / Q000187:drug effects*; D007421:Intestine, Small / Q000033:anatomy & histology / Q000378:metabolism; D007538:Isoniazid / Q000378:metabolism; D009355:Neomycin / Q000494:pharmacology*; D011802:Quinidine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013444:Sulfisoxazole / Q000378:metabolism
D013444:Sulfisoxazole; D009355:Neomycin; D011802:Quinidine; D007538:Isoniazid