title: [Immunodepressive action and effects of medroxyprogesterone acetate on the lymphatic tissue of the spleen of rabbits].
abstract: Present results demonstrated that medroxyprogesterone acetate (MPA) caused depletion of lymphoid splenic tissue in rabbits. This phenomenon, induced by corticoid action and antiproliferative activity of the hormonal agent, supported the immunodepressive properties of drug, which prolonged the survival of some allografts and lowered the antibody response to different antigens.
mesh_terms: D000818:Animals; D005260:Female; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008221:Lymphoid Tissue / Q000187:drug effects* / Q000276:immunology; D008297:Male; D008525:Medroxyprogesterone / Q000494:pharmacology*; D011817:Rabbits; D013154:Spleen / Q000187:drug effects* / Q000276:immunology
chemical_list: D007166:Immunosuppressive Agents; D008525:Medroxyprogesterone
vernacular_title: Azione immunodepressiva ed effetti del medrossiprogesterone acetato sul tessuto linfatico della milza di coniglio.