title: [Changes in the ultrastructure of the cerebral cortex in experimental chronic morphine poisoning and morphine withdrawal].
abstract: The ultrastructure of cortical neurons of rats was studied by electron microscopy in the dynamics of chronic morphine poisoning and discontinuation. Administrtion of monotonous (30 mg/kg) and increasing (from 30-480 mg/kg) doses of morphine followed by its discontinuation induced submicroscopic reconstruction of the endoplasmatic network and reactive changes in the neurons. It is suggested that impaired production of protein-synthesizing substances (endogenous polypeptide) points to an effect of morphine on the metabolic processes of neurons.
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000648:ultrastructure*; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure; D009021:Morphine Dependence / Q000473:pathology*; D011132:Polyribosomes / Q000648:ultrastructure; D051381:Rats; D012270:Ribosomes / Q000648:ultrastructure; D013375:Substance Withdrawal Syndrome / Q000473:pathology*
vernacular_title: Izmeneniia ul'trastruktury kory golovnogo mozga pri éksperimental'noĭ khronicheskoĭ morfinnoĭ intoksikatsii i otmene morfina.