6-Keto-PGE1 is a potent of relaxant of the fetual ductus arteriosus.
6-Keto-PGE1 is nearly as potent as PGE2 in relaxing the ductus arteriosus of fetal lambs. This finding raises the possibility that 6-keto-PGE1, if occurring naturally as a by-product of PGI2 transformations, may contribute to prenatal patency of the vessel.
D000527:Alprostadil / Q000031:analogs & derivatives*; D000818:Animals; D004373:Ductus Arteriosus / Q000187:drug effects* / Q000502:physiology; D005260:Female; D009126:Muscle Relaxation / Q000187:drug effects; D011247:Pregnancy; D011458:Prostaglandins E / Q000494:pharmacology*; D011459:Prostaglandins E, Synthetic; D012756:Sheep
D011458:Prostaglandins E; D011459:Prostaglandins E, Synthetic; C022950:6-ketoprostaglandin E1; D000527:Alprostadil