Modification of drug-induced catatonia and tremors by quapazine in rats and mice.
Administration of perphenazine, tremorine, nicotine and harmine induced Parkinson-like symptoms in rats and mice. The efficacy of quipazine, a serotonin agonist, in antagonizing these drug-induced Parkinsonian symptoms was assessed. Combinations of this drug with other antiparkinsonian agents such as scopolamine, diphenhydramine and amantadine were also studied in the manifestation of Parkinson-like symptoms in the animal models. The results indicate that quipazine, a central serotonergic agent, counteracted some of the drug-induced symptoms of pseudoparkinsonism in laboratory animals. Cholinergic, dopaminergic and histaminergic receptors play an important role in the manifestations of these symptoms.
D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology; D002389:Catatonia / Q000139:chemically induced*; D004338:Drug Combinations; D004347:Drug Interactions; D006247:Harmine / Q000494:pharmacology; D006801:Humans; D008297:Male; D051379:Mice; D009538:Nicotine / Q000037:antagonists & inhibitors; D010546:Perphenazine / Q000037:antagonists & inhibitors; D011804:Quinolines / Q000494:pharmacology*; D011814:Quipazine / Q000494:pharmacology*; D051381:Rats; D014202:Tremor / Q000139:chemically induced*; D014203:Tremorine / Q000037:antagonists & inhibitors
D000978:Antiparkinson Agents; D004338:Drug Combinations; D011804:Quinolines; D006247:Harmine; D011814:Quipazine; D009538:Nicotine; D010546:Perphenazine; D014203:Tremorine