High-titer glucagon antibodies in a hypoglycemic child on glucagon therapy.
High-titer (1:30,000) antiglucagon antibodies were detected in a 14-month-old patient with nesidioblastosis who had been treated by intramuscular long-acting glucagon since age 5 months. In this patient no correct equilibrium of blood glucose level could be obtained without maintaining glucagon treatment, even after subtotal pancreatectomy. Antiglucagon antibodies titer remained stable at age 18 months.
D000906:Antibodies / Q000032:analysis*; D005934:Glucagon / Q000276:immunology* / Q000627:therapeutic use; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications; D007003:Hypoglycemia / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy; D008297:Male
D000906:Antibodies; D005934:Glucagon