The effect of burn injury on the heart in the whole body and on the extracorporeally perfused isolated heart.
Cardiac performance during the initial stage of burn shock in dogs was studied in the whole body and compared with the function of the isolated hearts, perfused from donor animals similarly burned. Continuous recording of the functional indices using electro-magnetic flowmetry and ECG with on-line processing of the data enabled us to establish the following facts. Progressive decrease of cardiac output secondary to the depression of myocardial contractility against the background of stable inflow takes place as early as 2-5 minutes after massive burning in the whole body. No significant changes of the functional indices of the isolated hearts, perfused from the perfusion donors similarly burned, were observed in the second group of experiments. The underlying mechanisms of the above phenomena are discussed.
D000818:Animals; D001794:Blood Pressure; D002056:Burns / Q000503:physiopathology*; D002302:Cardiac Output; D004285:Dogs; D004562:Electrocardiography; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate; D009200:Myocardial Contraction; D013997:Time Factors