Comparison of the antigenicity of melanotic and amelanotic melanoma cells after the release of surface glycoproteins by trypsin.
The antigenicity of isolated cells of malanotic and amelanotic melanomas after the release of surface glycoproteins by trypsin was studied by the migration inhibition test. It has been found that after treatment with trypsin the antgenicity of melanotic melanoma cells increased, while the amelanotic melanoma cells lost their ability to inhibit macrophage migration.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D002462:Cell Membrane / Q000378:metabolism; D002464:Cell Migration Inhibition; D002478:Cells, Cultured; D006224:Cricetinae; D006023:Glycoproteins / Q000378:metabolism; D008264:Macrophages / Q000276:immunology; D008297:Male; D008545:Melanoma / Q000276:immunology* / Q000473:pathology; D008565:Membrane Proteins / Q000378:metabolism; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000473:pathology; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology*; D014357:Trypsin / Q000494:pharmacology
D000951:Antigens, Neoplasm; D006023:Glycoproteins; D008565:Membrane Proteins; D014357:Trypsin