The neurologic manifestations of sinus histiocytosis with massive lymphadenopathy.
Sinus histiocytosis with massive lymphadenopathy is a benign pseudolymphomatous disease with distinctive microscopic features. Painless cervical adenopathy is the most characteristic clinical finding, although other node groups and extranodal sites may be involved. Of 200 patients in a case registry, 8 had neurologic symptoms. The lesions included vertebral canal and intracranial infiltrates and a destructive vertebral body lesion. Two patients had both cord compression and intracranial disease; one of them died after 10 years of disease. Seven patients were alive 1 to 15 years after disease onset.
D000293:Adolescent; D000328:Adult; D002490:Central Nervous System / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006261:Headache / Q000209:etiology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000150:complications* / Q000473:pathology; D008297:Male; D008578:Meninges / Q000473:pathology; D008875:Middle Aged; D010264:Paraplegia / Q000209:etiology*; D010292:Paresthesia / Q000209:etiology*; D012021:Reflex, Abnormal / Q000209:etiology*