Pharmacokinetics of fentiazac in rats and monkeys.
Pharmacokinetic investigations were carried out on 2-phenyl-4-p-chlorophenyl-thiazol-5-ylacetic acid (fentiazac) in the rat and in the monkey. The drug, rapidly absorbed by the gastrointestinal system, shows a long maintenance in the body, with a long half-life in both animal species. The rate of biotransformation and the times of presence in the blood circulation of both unchanged drug and of its metabolites are indicated by the serum levels of cold fentiazac and labelled fentiazac. Urinary and fecal excretion attain levels amounting to 24 and 70%, respectively, of the dose administered.
D000085:Acetates / Q000378:metabolism*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism*; D001646:Bile / Q000378:metabolism; D005243:Feces / Q000032:analysis; D005260:Female; D007700:Kinetics; D008252:Macaca fascicularis; D008297:Male; D008954:Models, Biological; D051381:Rats; D012737:Sex Factors; D013844:Thiazoles / Q000378:metabolism*; D014018:Tissue Distribution
D000085:Acetates; D000893:Anti-Inflammatory Agents; D013844:Thiazoles; C006124:fentiazac