Synthesis, purification and conformational studies on enkephalin derivatives containing gamma-amino-n-butyric acid.
The solid-phase synthesis of several analogs of enkephalin containing gamma-amino-butyric acid is reported. Synthetic strategies, purification methods, chemical and physicochemical characterization are discussed. The n.m.r. data suggest for some of the analogs structural features similar to the opioids.
D002851:Chromatography, High Pressure Liquid; D004745:Enkephalins / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D005680:gamma-Aminobutyric Acid
D004745:Enkephalins; D005680:gamma-Aminobutyric Acid