Pharmacokinetic evidence for an enterohepatic circulation in a patient treated with cis-dichlorodiammineplatinum (II).
Platinum concentrations in plasma were measured by atomic absorption spectrometry during and after a 15 min intravenous infusion of cis-dichlorodiamineplatium (II) (cis-platinum) at a dose of 100 mg/m2. Plasma concentrations of platinum declined biexponentially (t 1/2 alpha = 21.3 min, t 1/2 beta = 6.2 days). A small peak was noticed at 3.5 hrs after the end of the infusion, indicating a renewed influx of platinum in the plasma compartment. This phenomenon is strongly suggestive for the presence of an enterohepatic circulation.
D000231:Adenocarcinoma, Papillary / Q000188:drug therapy; D000328:Adult; D002945:Cisplatin / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D004764:Enterohepatic Circulation; D005260:Female; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D010051:Ovarian Neoplasms / Q000188:drug therapy; D010984:Platinum / Q000097:blood; D013054:Spectrophotometry, Atomic; D013997:Time Factors
D010984:Platinum; D002945:Cisplatin