Catalepsy produced by long-acting neuroleptics, fluphenazine enanthate and fluphenazine decanoate, in mice.
The cataleptic state induced by the depot-type preparations of fluphenazine (FZ) was investigated in mice. Intramuscular injections of FZ-enanthate or FZ-decanoate produced a marked and long-lasting catalepsy, which was antagonized by trihexyphenidyl, biperiden and promethazine but not by l-dopa. These anticataleptic effects disappeared after several hours and catalepsy occurred again. The cataleptic effects of FZ-enanthate and FZ-decanoate were increased by (D-Ala2, MePhe4, Met(0)5-ol)-enkephalin, aminooxyacetic acid and haloperidol. The results indicate that the cataleptic effects of FZ-enanthate and FZ-decanoate correspond with their long duration of antipsychotic effects and that the catalepsy may involve enkephalinergic, GABAergic and cholinergic as well as dopaminergic neuron activity.
D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology; D002375:Catalepsy / Q000139:chemically induced*; D003692:Delayed-Action Preparations; D004357:Drug Synergism; D004745:Enkephalins / Q000494:pharmacology; D005476:Fluphenazine / Q000009:adverse effects / Q000031:analogs & derivatives*; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects
D000978:Antiparkinson Agents; D003692:Delayed-Action Preparations; D004745:Enkephalins; D011954:Receptors, Dopamine; D000625:Aminooxyacetic Acid; C011825:fluphenazine depot; D006220:Haloperidol; C017610:fluphenazine enanthate; D005476:Fluphenazine