Friend viral pathogenesis in C57BL/6 reversible DBA/2 allophenic mice.
Infection of mice with Friend erythroleukemia virus initially causes massive proliferation of erythroid precursors accompanied by splenomegaly and reticulocytosis. Strains of mice differ among themselves in susceptibility to Friend virus and one of the major genes affecting the early response to viral infection is Fv-2. Allophenic mice compounded from a resistant strain C57BL/6 (Fv-2rr) and a susceptible one DBA/2 (Fv-2ss) were infected with the polycythemic strain of Friend virus to determine whether susceptibility/resistance was limited to cells of the respective genotypes or if there was an influence across the genotypic barriers. The manifestations of viral pathogenesis monitored were splenomegaly, reticulocytosis and leukocytosis. In addition, the proportion of red cells of the two genotypes in each animal was monitored before and after viral infection by analyses for strain specific electrophoretic variants of hemoglobin and glucose phosphate isomerase. The group of allophenic mice with 25% or more susceptible-strain red blood cells all developed symptoms of virus-induced disease and also revealed dramatic increases in the number of red cells of the susceptible-strain genotype. Thus, no evidence for protection of susceptible-strain cells by ones of the resistant strain could be observed and the disease developed primarily in susceptible strain cells. On the other hand infected animals with 15% or less DBA/2 red cells were severely retarded in the development of Friend disease. Under these circumstances susceptible strain target cells might fail to undergo viral induced replication as a result of direct protection by resistant strain cells. Alternatively, other more complex mechanisms might be involved such as protective anti-viral immune reactions.
D000818:Animals; D001772:Blood Cell Count; D004198:Disease Susceptibility; D004920:Erythropoiesis; D005622:Friend murine leukemia virus; D005956:Glucose-6-Phosphate Isomerase / Q000097:blood; D006454:Hemoglobins / Q000235:genetics; D007964:Leukocytosis / Q000150:complications; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D008811:Mice, Inbred DBA / Q000235:genetics*; D009030:Mosaicism; D011086:Polycythemia / Q000150:complications / Q000209:etiology* / Q000235:genetics; D012156:Reticulocytes; D013163:Splenomegaly / Q000150:complications
D006454:Hemoglobins; D005956:Glucose-6-Phosphate Isomerase