[Preliminary results of a pilot study on the influence of pemoline on cerebral concentrations of lactate, pyruvate, creatine, creatinephosphate, ATP, AMP, and ADP (author's transl)].
Cerebral lactate, pyruvate, ATP, ADP, creatine and phosphocreatine concentrations were determined in old, 600 g, rats during daily application of 20 mg pemoline (Tradon) (n = 11) and placebo (n = 10). After application for 21 days there were observed no significant differences in ATP, ADP, AMP, creatine and phosphocreatine concentrations between pemoline and placebo treated rats. On the other hand, in pemoline-rats, there was a significant decrease in pyruvate, lactate concentrations and in lactate/pyruvate ratio. On account of an increased dopamine turnover caused by pemoline, a possible increasing aerobic glycolysis and thus a greater energy production are still being discussed.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D003401:Creatine / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects; D007773:Lactates / Q000378:metabolism; D010389:Pemoline / Q000494:pharmacology*; D010725:Phosphocreatine / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D051381:Rats
D007773:Lactates; D011773:Pyruvates; D010725:Phosphocreatine; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D010389:Pemoline; D000255:Adenosine Triphosphate; D003401:Creatine; D004298:Dopamine
Erste Ergebnisse einer Pilot-Studie zum Einfluss von Pemolin auf die zerebralen Lactat-, Pyruvat-, Creatin-, Creatinphosphat-, ATP-, AMP- und ADP-Konzentrationen.