cis-Dichlorodiammineplatinum(II) in the treatment of esophageal carcinoma.
Seventeen consecutive patients with untreated squamous cell carcinoma of the esophagus were treated with cis-dichlorodiammineplatinum(II) (DDP) by infusion at a dose of 3 mg/kg with mannitol diuresis. One patient had a partial response and six additional patients had subjective improvement in dysphagia and associated weight gain; however, no complete responses were noted. Toxic effects were mainly renal. There were no drug-related deaths. We conclude that DDP alone is not effective in squamous cell carcinoma of the esophagus.
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002945:Cisplatin / Q000009:adverse effects / Q000627:therapeutic use*; D004938:Esophageal Neoplasms / Q000188:drug therapy*; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008297:Male; D008875:Middle Aged
D002945:Cisplatin