title: [Phospholipid composition, lipid peroxidation, and activity of enzymes of hepatocyte organoids in alcoholic intoxication].
abstract: During chronic ethanol intoxication phase alterations in phospholipid composition and in intensity of oxidation were observed in liver microsomes and mitochondria. The oxidative reactions were most pronounced within the first 15 and 30 days as shown by an increase in activity of malate- and isocitrate dehydrogenases from the mitochondrial fraction. Administration of ethanol within 15 days was accompanied by an increase in content of phospholipids and their separate fractions both in microsomes and in mitochondria. In microsomes content of lipid peroxides was distinctly increased but content of free phospholipid fractions was most distinctly lowered within 90 days.
mesh_terms: D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D008054:Lipid Peroxides / Q000032:analysis*; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D010743:Phospholipids / Q000032:analysis*; D051381:Rats; D013997:Time Factors
chemical_list: D008054:Lipid Peroxides; D010743:Phospholipids; D010088:Oxidoreductases; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D005969:Glutamate Dehydrogenase
vernacular_title: Fosfolipidnyĭ sostav, perekisnoe okislenie i aktivnost' nekotorykh fermentov organoidov gepatotsitov pri aklogol'noĭ intoksikatsii.