Role of monoamines in behavior of reserpinized rats given tranylcypromine stereoisomers.
The effects of tranylcypromine stereoisomers [(+)-TCP and (-)-TCP] on behavior were studied in reserpinized rats. Rats given reserpine showed a behavioral syndrome characterized by hypoactivity. Administration of (+)-TCP to reserpinized rats led to a dose-dependent increase in their locomotor activity. At a dose of 15 mg/kg, (+)-TCP produced activation, stereotypy and hyperstimulation in reserpinized rats. In contrast, (-)-TCP failed to influenced the behavior of reserpinized rats reliably. Pharmacological studies using agonists and antagonists of monoaminergic functions showed the actions of (+)-TCP to depend on presynaptic serotonergic and catecholaminergic functions. The results provide another example of stereoselective effects of tranylcypromine stereoisomers on behavior mediated mainly by monoaminergic neurotransmission.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*; D013237:Stereoisomerism; D013239:Stereotyped Behavior / Q000187:drug effects; D013329:Structure-Activity Relationship; D014191:Tranylcypromine / Q000494:pharmacology*
D014191:Tranylcypromine; D012110:Reserpine