[Experience with vaginal suppositories containing chemotherapeutic agents (author's transl)].
The authors determined the release of chloramphenicol, oxytetracycline, neomycin and sulphadimidine from different bases (polyoxethene mass, solid fat, 95% solid fat +5% Span 20). The diffusion of chloramphenicol and sulphadimidine was best from hydrophilic bases; that of oxytetracycline and neomycin, from emulsifier-containing lipophil bases. This may be explained by the solubilities of the pharmaca and by interactions between base and active substance.
D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002626:Chemistry, Pharmaceutical; D002701:Chloramphenicol / Q000008:administration & dosage; D004058:Diffusion; D005260:Female; D009355:Neomycin / Q000008:administration & dosage; D010118:Oxytetracycline / Q000008:administration & dosage; D012995:Solubility; D013418:Sulfamethazine / Q000008:administration & dosage; D013488:Suppositories; D014621:Vagina
D000890:Anti-Infective Agents; D013488:Suppositories; D013418:Sulfamethazine; D002701:Chloramphenicol; D009355:Neomycin; D010118:Oxytetracycline
Erfahrungen mit chemotherapeuticahaltigen Vaginalsuppositorien.