[Effect of amizil and galantamin on the behavioral effects of apomorphine in rats].
Stereotypy and locomotor hyperactivity caused by subcutaneous injection of apomorphine (1-5 mg) were quantitated with an "Animex-DSE" motility meter. Intraperitoneal administration of galantamin in a dose of 2.5 mg/kg 10 minutes before apomorphine reversed the latter's effect. However, when injected in a similar way 40 minutes before, it exerted no action on behavioral effects of apomorphine. Intraperitoneal administration of amizyl in a dose of 1 mg/kg completely prevented antagonism of galantamin to apomorphine activity but did not potentiate its effect on the locomotor activity in the animals. The data obtained show that the effect of the cholinergic system on dopaminergic mediation in individual brain structures may be modulating in nature. The experimental data are discussed in the light of the present-day concepts of the function of dopamine receptors in the striatum and mesolimbic systems of the brain.
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors*; D001535:Benactyzine / Q000494:pharmacology*; D005702:Galantamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*
D005702:Galantamine; D001535:Benactyzine; D001058:Apomorphine
Vliianie amizila i galantamina na povedencheskie éffekty apomorfina u krys.