Demonstration of a two-step reaction mechanism for inhibition of alpha-thrombin by antithrombin III and identification of the step affected by heparin.
D000990:Antithrombin III / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D013050:Spectrometry, Fluorescence; D013917:Thrombin / Q000378:metabolism*
D000990:Antithrombin III; D006493:Heparin; D013917:Thrombin