title: [Morphological characteristics of healing of extensive purulent wounds during treatment in the controlled bacteria-free environment].
abstract: Histological, histochemical and cytological techniques were used to examine the healing of extensive purulent wounds treated in a controlled abacterial medium (an open-type method of treatment). Biopsies were taken from 25 patients and explored throughout the entire treatment course (from 1 to 26 days). It was shown that the treatment brought about acceleration of wound purification and reparation. Wound tissues manifested a drastic lowering of the content of microflora and polymorphonuclear neutrophils. On days 3-5 of the treatment in the wound cavity there appeared close-grained granulations containing mature macrophages with high phagocytic activity and proliferating fibroblasts. On days 7-10 there emerged mature granulation tissue well fit for autodermoplasty.
mesh_terms: D002452:Cell Count; D006097:Granulation Tissue / Q000473:pathology; D006801:Humans; D008264:Macrophages / Q000166:cytology; D009504:Neutrophils / Q000166:cytology; D010357:Patient Isolators; D014945:Wound Healing; D014946:Wound Infection / Q000517:prevention & control*; D014947:Wounds and Injuries / Q000473:pathology / Q000628:therapy*
vernacular_title: Morfologicheskie osobennosti zazhivleniia obshirnykh gnoĭnykh ran pri lechenii v upravliaemoĭ abakterial'noĭ srede.