title: The chemotherapeutic value of sulphadiazine in treatment of Acanthamoeba meningoencephalitis in mice.
abstract: The chemotherapeutic value of three sulphonamides, sulphamethizole, sulphamethoxazole and sulphadiazine, was examined in experimental Acanthamoeba meningoencephalitis in mice. Only sulphadiazine was capable of protecting mice challenged with A. culbertsoni A-1 strain. However, protection to mice was only afforded if the drug was given early after infection. Once the amoebae reached, and became established in, the central nervous system, sulphadiazine displayed no chemotherapeutic value.
mesh_terms: D000562:Amebiasis / Q000188:drug therapy*; D000818:Animals; D005260:Female; D008590:Meningoencephalitis / Q000188:drug therapy* / Q000209:etiology; D051379:Mice; D008807:Mice, Inbred BALB C; D013411:Sulfadiazine / Q000627:therapeutic use*; D013419:Sulfamethizole / Q000627:therapeutic use; D013420:Sulfamethoxazole / Q000627:therapeutic use
chemical_list: D013411:Sulfadiazine; D013419:Sulfamethizole; D013420:Sulfamethoxazole