Humoral growth factor after small intestinal resection in the dog.
The serum of dogs with a 50% proximal small bowel resection is capable of growth stimulation in small intestinal epithelioid cells in monolayer culture. This overstimulation by postresection serum is not seen when dogs undergo either a small intestinal transection or a simple laparotomy or with baby hamster kidney fibroblast cells in culture. The effect does not seem to be represented by a gastrinlike molecule. This study lends support to the hypothesis that a humoral factor is involved in small intestinal adaptation after partial resection.
D000818:Animals; D002478:Cells, Cultured; D004285:Dogs; D004847:Epithelial Cells; D005347:Fibroblasts / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism; D006133:Growth Substances / Q000097:blood* / Q000502:physiology; D007421:Intestine, Small / Q000166:cytology / Q000601:surgery*; D007813:Laparotomy; D011184:Postoperative Period
D005755:Gastrins; D006133:Growth Substances