Central nervous system lipid alterations in rats with experimental allergic encephalomyelitis and its suppression by immunosuppressive drugs.
Rats with experimental allergic encephalomyelitis (EAE) induced with myelin or spinal cord show decreases in the content of sulphatides and cerebrosides and increases in the level of esterified cholesterol in the CNS. In this work it is shown that brain sulphatide changes can be obtained by injection of mixtures containing glycosphingolipids. Alterations in the content of cerebrosides occur when the injection mixture contains cerebrosides. The alterations of sulphatides and cholesterol ester induced by injection of spinal cord could be suppressed by treatment with immunosuppressive drugs (dexamethasone, cyclophosphamide and 6-mercaptopurine) able to prevent clinical signs of EAE.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002554:Cerebrosides / Q000378:metabolism; D002788:Cholesterol Esters / Q000378:metabolism; D003520:Cyclophosphamide / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000378:metabolism*; D005260:Female; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D050356:Lipid Metabolism; D008297:Male; D015122:Mercaptopurine / Q000494:pharmacology; D009186:Myelin Sheath / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism*; D013433:Sulfoglycosphingolipids / Q000378:metabolism
D002554:Cerebrosides; D002788:Cholesterol Esters; D007166:Immunosuppressive Agents; D013433:Sulfoglycosphingolipids; D003907:Dexamethasone; D003520:Cyclophosphamide; D015122:Mercaptopurine