Vasopressin analogues and spatial working memory in the 24-arm radial maze.
The effect of vasopressin analogues dAVP, dDAVP, and desgly NH2 dDAVP on working memory was tested in the 24-arm radial maze in twelve 6-month-old and twelve 19-month-old rats. No age dependent effects were found. All three peptides tested (3 micrograms/kg) tended to improve the performance but only the desgly NH2 dDAVP significantly decreased the number of errors. A second application of desgly NH2 dDAVP was ineffective. The specificity of activation of memory mechanisms by desgly NH2 dDAVP can be questioned.
D000818:Animals; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D013028:Space Perception / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013997:Time Factors; D014667:Vasopressins / Q000494:pharmacology*
D014667:Vasopressins