title: Aging and CSF hydroxylase cofactor.
abstract: The level of cerebrospinal fluid (CSF) hydroxylase cofactor activity was measured in 34 neurologically normal patients and analyzed according to age. Levels declined by approximately one-third over a 40-year span, probably reflecting loss of aminergic neurons. Fourteen patients with Parkinson disease all tended to have lower values than age-matched controls. Among Parkinson patients with the same order of disability, younger cases had higher CSF concentratons of hydroxylase cofactor than older patients.
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D001708:Biopterins / Q000031:analogs & derivatives / Q000134:cerebrospinal fluid*; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000201:enzymology; D011621:Pteridines / Q000134:cerebrospinal fluid*
chemical_list: D011621:Pteridines; D001708:Biopterins; C003402:sapropterin