title: Toxicity study with sodium picosulfate in cultured liver cells of rabbit, rat and man.
abstract: The effect of sodium picosulfate was examined in liver cell cultures of rabbit, rat and man exposed to substance concentrations of 25, 50, 100, 200, 400, 800 and 1600 micrograms/ml. At 400, 800 and 1600 micrograms/ml the rapidly growing cultured liver cells of rabbit showed dose-dependently vacuolic and fatty change as well as necrosis combined with a lowered mitotic activity and a slight increase in LDH values in the medium at 800 and 1600 micrograms/ml. Comparable but less severe effects were observed in 4-day old liver cell cultures of rat, while liver cells cultured for 6 to 11 days tolerated 1600 micrograms/ml sodium picosulfate. In human liver cultures the number of cells was slightly lowered at 800 and 1600 micrograms/ml and the number of nuclei in division was decreased dependent on dose.
mesh_terms: D000818:Animals; D002400:Cathartics / Q000633:toxicity*; D002478:Cells, Cultured; D002951:Citrates; D006801:Humans; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D008938:Mitosis / Q000187:drug effects; D009942:Organometallic Compounds; D010847:Picolines / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
chemical_list: D002400:Cathartics; D002951:Citrates; D009942:Organometallic Compounds; D010847:Picolines; C005701:picosulfate sodium