The effect of combined treatment of hypoxic L5178Y-R and L5178Y-S cells with lidocaine and X-rays.
Combination of lidocaine (6 mg/ml) and X-rays was used for treatment of two strains of L5178Y lymphoma cells under hypoxic conditions. The strains L5178Y-S (radiosensitive) and L5178Y-R (radioresistant) differ in radiosensitivity by a factor of about 1.4 whereas they are equally sensitive to lidocaine. For combined treatment of L5178Y-R cells the enhancement ratio was 1.4 and for that of L5178Y-S cells 1.0. Cell partition between two aqueous polymer phases [Dextran T500 and poly(ethylene glycol) 6000] does reflect neither viability nor the commitment of treated cells to interphase or reproductive death.
D002470:Cell Survival / Q000187:drug effects* / Q000528:radiation effects; D002478:Cells, Cultured; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology*; D008223:Lymphoma / Q000473:pathology*; D010100:Oxygen; D011836:Radiation Tolerance
D008012:Lidocaine; D010100:Oxygen