The effect of intracisternally administered bombesin on cysteamine-induced duodenal ulcers in rats.
Cysteamine (420 mg/kg s.c.) increased gastric acid secretion in rats 3-6 h post-injection; duodenal pH fell from 6.0 +/- 0.2 (S.E.M.) at 0 time to 2.2 +/- 0.3 at 12 h. A high (60-80%) incidence of duodenal ulcerations was observed 18 h after cysteamine injection. Intracisternal (i.c.) administration of bombesin (1 microgram) significantly inhibited both cysteamine-induced increases in gastric acid secretion and the development of duodenal ulcers. This effect of bombesin was dose-dependent and appears to be relatively specific since i.c. neurotensin (1 or 30 micrograms) was not cytoprotective. Peripheral cholinergic (muscarinic) blockade with atropine methylbromide (10 mg/kg i.p.) was as effective as i.c. bombesin (1 microgram) in inhibiting cysteamine-induced gastric hypersecretion and duodenal ulcers.
D000818:Animals; D001286:Atropine Derivatives / Q000494:pharmacology; D001839:Bombesin / Q000008:administration & dosage / Q000494:pharmacology*; D002946:Cisterna Magna; D003543:Cysteamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D007267:Injections; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001286:Atropine Derivatives; D010455:Peptides; D003543:Cysteamine; C006649:methylatropine; D001839:Bombesin