Loss of eye movements abolishes light entrainment of circadian mesolimbic catecholamine excitability: a function for REM?
Light entrainment of the circadian rhythm of mesolimbic dopamine excitability, measured by the amphetamine-induced locomotor response, and the circadian feeding rhythm was abolished following section of the extraocular muscles of the rat. Endogenous (free-running) circadian rhythms were preserved. The results are consistent with electrophysiologic evidence that the rapid eye movements during paradoxical sleep transmit light-modulated electrical potentials to regions of the brain that influence circadian rhythms and dopamine release.
D000818:Animals; D002395:Catecholamines / Q000502:physiology*; D002940:Circadian Rhythm; D003913:Dextroamphetamine / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology; D005133:Eye Movements; D006801:Humans; D008027:Light; D008124:Locomotion / Q000187:drug effects; D008297:Male; D010775:Photic Stimulation; D011595:Psychomotor Agitation; D051381:Rats; D012895:Sleep, REM / Q000502:physiology*
D002395:Catecholamines; D003913:Dextroamphetamine; D004298:Dopamine