[On the effect of imipramine on blood composition, glucose level and alkaline phosphatase activity of leucocytes in non-emotive Wistar rats and animals of inbred TMB strain (author's transl)].
The acute effect of imipramine (Tofranil) on the composition of blood, blood sugar level and activity of alcaline phosphatase in leucocytes was studied in an experiment with 30 adult male TMB-rats. These findings were compared with those in non-emotive Wistar rats (the scores without stress and under the condition of psycho-pharmacological effects) as far as corresponding motor activity in both strains was concerned. Hematological findings in a non-stress condition are considered to be identical in both strains studied. Under the acute effect of imipramine only about 50% of the compared parameters are similar to each other. The differing course of the hematological reaction within the other 50% points to the presence of non-identical control mechanisms in both strains.
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001769:Blood / Q000187:drug effects*; D001772:Blood Cell Count; D001786:Blood Glucose / Q000378:metabolism; D004644:Emotions / Q000502:physiology*; D007099:Imipramine / Q000494:pharmacology*; D007962:Leukocytes / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D000469:Alkaline Phosphatase; D007099:Imipramine
Zur Frage der Wirkung von Imipramin auf das Blutbild, den Glukosespiegel und die Aktivität der alkalischen Leukozyten-Phosphatase nichtemotiver Wistar-Ratten und Tiere des Inzuchtstammes TMB (Tryon-Maze-Bright).