title: An epidemiological and genetic study of facial clefting in France. I. Epidemiology and frequency in relatives.
abstract: The frequencies of cleft lip with or without cleft palate (CL(P)) and isolated cleft palate (CP) have been estimated in France to be 0.082% and 0.035%, respectively, after exclusion of malformation syndromes. A genetic and epidemiological study has been carried out on 468 patients with CL(P) and 163 with CP. The results are given in detail and some specific points are discussed: the apparently low incidence in France, the relationship between sex ratio and abortion rates, the maternal effects, and the possibility of an association between CL(P) and CP.
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology; D002971:Cleft Lip / Q000150:complications / Q000235:genetics*; D002972:Cleft Palate / Q000150:complications / Q000235:genetics*; D005260:Female; D005602:France; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008423:Maternal Age; D011247:Pregnancy; D012744:Sex Ratio