Altered lipid profile in liver amoebiasis and its emendation with metronidazole treatment.
Liver amoebic abscess was produced by introducing 16,000 trophozoites of Entamoeba histolytica directly into the livers of growing hamsters. A group of the infected animals received orally 64 mg metronidazole/kg body weight for 5 days from the day of the infection. The treated group was autopsied 7 or 14 days after the treatment. Histologically, liquefaction of large parenchymal areas and biochemically, elevation in cholesterol, triglycerides, bile acids and decrease in phospholipids were observed in infected livers. The infected hamsters exhibited hyperlipidemia and hypocholesterolemia. With metronidazole treatment all the values tended to shift towards control levels. The magnitude of the shift was determined by the post-treatment period.
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D006224:Cricetinae; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008101:Liver Abscess, Amebic / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D014280:Triglycerides / Q000378:metabolism
D001647:Bile Acids and Salts; D014280:Triglycerides; D008795:Metronidazole; D002784:Cholesterol