Acute loxapine intoxication in a child.
Thin-layer chromatography (TLC) was used to confirm the alleged ingestion of Loxitane (loxapine succinate) by a 20-month-old child. GC was used to further characterize TLC spots and to quantitate the loxapine concentration of the blood at 0.072 mg/dL, which was consistent with the child's presenting signs of lethargy and ataxia. The appropriate supportive symptomatic therapy, with monitoring for CNS and cardiovascular toxicities, resulted in an uneventful recovery.
D003989:Dibenzoxazepines / Q000506:poisoning*; D005260:Female; D005750:Gastric Juice / Q000032:analysis; D006801:Humans; D007223:Infant; D008152:Loxapine / Q000032:analysis / Q000097:blood / Q000506:poisoning*
D003989:Dibenzoxazepines; D008152:Loxapine