[Antagonistic effects of glucocorticoids and aristolochic acid on the immunocyte adherence phenomenon (author's transl)].
The influence of prednisolone and 3,4-methylenedioxy-8-methoxy-10-nitrophenanthrenecarbonic acid-1 (aristolochic acid) on the immunocyte adherence phenomenon in the rat was investigated. The following results were obtained: Prednisolone diminishes the number of rosettes. Aristolochic acid itself has no influence on the number of rosettes but compensates the diminuation caused by prednisolone. Equal effects were found for 5 mg/kg b.w. prednisolone and 0.005 mg/kg aristolochic acid. This effect of aristolochic acid is interpreted as competitive inhibition of surface receptors of lymphocytes.
D000818:Animals; D034341:Aristolochic Acids; D004347:Drug Interactions; D005938:Glucocorticoids / Q000494:pharmacology*; D008214:Lymphocytes / Q000276:immunology; D010616:Phenanthrenes / Q000494:pharmacology*; D011239:Prednisolone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012397:Rosette Formation
D034341:Aristolochic Acids; D005938:Glucocorticoids; D010616:Phenanthrenes; C000228:aristolochic acid I; D011239:Prednisolone
Gegensätzliche Wirkung von Glukokortikoiden und Aristolochiasäure auf das Immunozytoadhärenzphänomen.