The effect of ethanol on early manifestations of recovery from vestibular lesion.
The effect of intraperitoneal (i.p.) injection of ethanol (250 mg/kg) on compensatory rate of vestibular symptoms after unilateral labyrinthectomy was studied in guinea pigs. The treated group showed a faster dampening of vestibular disturbances in comparison with control animals. Both ocular and postural asymmetries declined to at least 50% of peak values after 2-3 h following alcohol injection. In control animals the same extent of compensation was achieved in 5-8 h after saline injection. This accelerating action of ethanol on early manifestations of vestibular compensation can be obtained by means of an increased inhibitory influence on vestibular nuclei and of an increased information provided by sensory systems.
D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D003714:Denervation; D004292:Dominance, Cerebral / Q000187:drug effects*; D007758:Ear, Inner / Q000294:innervation*; D000431:Ethanol / Q000494:pharmacology*; D006168:Guinea Pigs; D009760:Nystagmus, Physiologic / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D011187:Posture; D014726:Vestibular Nuclei / Q000187:drug effects*
D000431:Ethanol