Sequential morphogenesis of urinary bladder tumors in BALB/c mice given 2-acetylaminofluorene.
The sequential morphogenesis of bladder tumors induced in mice with 2-acetylaminofluorene were studied in order to understand better the morphogenesis of bladder tumors in humans. The study indicated 2 distinct patterns in the sequential morphogenesis. The first was a focal neovascularizaton of the transitional epithelium resulting initially in exophytic nodules which appeared more likely to develop into papilloma. The second was a nodular downgrowth of the transitional epithelium resulting initially in endophytic tumors which progressed to endophytic and exophytic carcinomas. Further work is needed to explain the significance of the 2 separate pathways which sometimes led to the same end result.
D015073:2-Acetylaminofluorene; D000818:Animals; D002295:Carcinoma, Transitional Cell / Q000098:blood supply / Q000139:chemically induced*; D004848:Epithelium / Q000473:pathology; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000139:chemically induced; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000098:blood supply / Q000139:chemically induced*
D015073:2-Acetylaminofluorene