Catalytic mechanism of histone in peptide formation from phenylalanyl adenylate.
Catalytic action of histone on peptide formation from phenylalanyl adenylate was studied. A peptide bond formation from phenylalanyl adenylate releases two protons. The proton release was increased in the presence of histone at a higher concentration. The catalytic action seems to be due to basic circumstance induced by histone, since (1) basic condition enhanced the proton release; (2) basic amino acid did not enhance the proton release.
D000249:Adenosine Monophosphate / Q000031:analogs & derivatives*; D000818:Animals; D002417:Cattle; D006657:Histones / Q000378:metabolism*; D007700:Kinetics; D010455:Peptides / Q000138:chemical synthesis*; D013950:Thymus Gland
D006657:Histones; D010455:Peptides; C026617:phenylalanyl adenylate; D000249:Adenosine Monophosphate