title: The open field: a simple method to show ethanol withdrawal symptoms.
abstract: The effects of withdrawal from chronic ethanol administration on locomotion and rearing frequencies of rats and mice were studied. Ethanol withdrawal induced a significant increase in animal's activity. In mice a positive correlation was found between locomotion plus rearing frequencies and audiogenic-induced seizures susceptibility 25 hr after ethanol removal. Results show that general activity evaluated through the open-field method might be used as a simple, non-drastic and reliable procedure to detect ethanol withdrawal symptoms in laboratory animals.
mesh_terms: D000161:Acoustic Stimulation; D000428:Alcohol Drinking; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012640:Seizures / Q000523:psychology; D013375:Substance Withdrawal Syndrome / Q000523:psychology*
chemical_list: D000431:Ethanol