[True XX/XY hermaphrotide, HY antigen positive, without detectable testicular tissue. Observation from birth to the age of ten years (author's transl)].
A rare modification of true Hermaphroditism is demonstrated in a ten-year-old child we have observed since birth. The cytogenetic analysis revealed a XX/XY-mosaicism. Two kinds of origin are discussed: 1. an ovum with two nuclei was fertilized by two different sperm cells, 2. two heterosexual zygotes fused. -- We could not find tissue of the testes but confirmed the diagnosis of a hermaphroditism by the detection of the HY-antigen and by typical endocrinological findings. Two different cell populations found in erythrocytes and by GPT-isoenzymes indicated a chimerism. By knowledge of these findings, we could help the child to undergo a positive psychological and social development.
D001706:Biopsy; D002648:Child; D002678:Chimera; D012734:Disorders of Sex Development / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D004912:Erythrocytes; D005260:Female; D006182:H-Y Antigen / Q000032:analysis*; D006801:Humans; D008297:Male; D009030:Mosaicism
D006182:H-Y Antigen
Echter XX/XY hermaphrodit mit positivem H-Y-Antigen ohne aufgefundenes Testisgewebe. Beobachtung von Geburt bis zum 10. Lebensjahr.