Neurologic complications of lymphomatoid granulomatosis.
Lymphomatoid granulomatosis is a malignant form of pulmonary angiitis that has characteristics in common with Wegener granulomatosis and lymphoma. Neurologic symptoms occur in up to 30% of the cases and are the presenting complaints in up to 21%. CNS, cranial nerve, and peripheral nerve involvement occur singly or in combination. In the CNS there is a pathologic triad of angiitis, lymphoreticular infiltration, and necrosis. In the involved peripheral nerves there is demyelination and lymphoid cell infiltration. Neurologic involvement tends to indicate a worse prognosis. Treatment has been based on steroids and cytotoxic agents and may improve symptoms but does not seem to alter the disease process.
D000328:Adult; D003389:Cranial Nerve Diseases / Q000209:etiology; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008230:Lymphomatoid Granulomatosis / Q000150:complications*; D009422:Nervous System Diseases / Q000175:diagnosis / Q000209:etiology*; D009886:Ophthalmoplegia / Q000209:etiology; D010243:Paralysis / Q000209:etiology; D014321:Trochlear Nerve