Synthesis of gamma-L-glutamyl-taurine.
Glu(Tau), a bioactive substance previously isolated from the protein free aqueous extract of bovine parathyroid powder, has been synthesized. The intermediate derivative Z-Glu(Tau)-OBzl was prepared in three different ways from Z-Glu-OBzl and (1) cystamine by using the mixed anhydride method followed by oxidation, (2) Tau by the active ester procedure via Z-Glu-(ONp)-OBzl, (3) Tau applying mixed anhydride coupling. The protecting groups were removed by hydrogenolysis.
D000818:Animals; D002417:Cattle; D005973:Glutamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D007202:Indicators and Reagents; D008722:Methods; D010280:Parathyroid Glands; D013654:Taurine / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D007202:Indicators and Reagents; D005973:Glutamine; D013654:Taurine; C020903:glutaurine