Corticosteroids and lepromin sensitivity.
Corticosteroids are known to influence the hypersensitivity reaction in a number of diseases involving hypersensitivity of tissues and alter the antigen antibody reactions in vivo. Corticosteroids administered in thirty tuberculoid cases for a period of 3 weeks showed negative response in the lepromin positive cases uniformly thereby proving suppression of cell mediated immunity in tuberculoid cases under the influence of corticosteroids; hence polar concept of tuberculoid type may be under question with continuous and prolonged corticosteroid therapy under necessity.
D000293:Adolescent; D000328:Adult; D001623:Betamethasone / Q000494:pharmacology*; D002648:Child; D006801:Humans; D006968:Hypersensitivity, Delayed; D007916:Lepromin / Q000276:immunology*; D007918:Leprosy / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D007916:Lepromin; D001623:Betamethasone