The effects of long-term feeding of soya flour on the rat pancreas.
Rats were fed raw and heated soya flour for up to 2 years. The rats fed raw soya flour all developed pancreatic hypertrophy and hyperplastic and adenomatous nodules. Four of 26 rats fed raw soya flour continuously and 1 of 5 rats fed raw soya flour for 2 days each week developed pancreatic cancer. Preheating the soya flour seemed to protect against the pancreatic hyperplastic and neoplastic changes.
D000236:Adenoma / Q000139:chemically induced*; D000818:Animals; D006965:Hyperplasia / Q000139:chemically induced; D006984:Hypertrophy / Q000139:chemically induced; D008297:Male; D010179:Pancreas / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000139:chemically induced*; D051381:Rats; D013025:Glycine max / Q000633:toxicity*; D013997:Time Factors