title: Dose-dependent increase in concentrations of gastric inhibitory polypeptide and pancreatic polypeptide after small amounts of glucose intraduodenally in man.
abstract: Nine healthy volunteers were infused intraduodenally with 100 ml isotonic solutions of 1, 2.5, and 5 g glucose for 15 min at 1-h intervals. The gastric inhibitory polypeptide (GIP) concentration in plasma did not increase after 1 g of glucose, whereas after 2.5 g of glucose the GIP concentration increased from 32.1 (23.3-68.4) to 53.9 (30.0-63.0) pM and after 5 g from 36.8 (18.0-54.7) to 78.5 (46.9-163) pM. The serum concentration of pancreatic polypeptide (PP) increased only after 5 g, from 19.3 (14.8-29.1) to 28.8 (15.3-45.3) pM. This shows that the plasma concentration of GIP increases dose-dependently after small doses of duodenal glucose and that glucose really is a duodenal stimulus for an increase i serum PP concentration.
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D004386:Duodenum; D005749:Gastric Inhibitory Polypeptide / Q000097:blood*; D005768:Gastrointestinal Hormones / Q000097:blood*; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D010191:Pancreatic Polypeptide / Q000097:blood*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D005768:Gastrointestinal Hormones; D005749:Gastric Inhibitory Polypeptide; D010191:Pancreatic Polypeptide; D005947:Glucose