Absorption of 14C-clanobutin-Na in blood-perfused tied-off jejunal segments in vivo of rats.
1. Absorption, elimination and retention of 14C-clanobutin was investigated on tied-off jejunal segments in situ of rats. 2. 14C-clanobutin completely disappeared from the intestinal lumen within 15-90 min depending on the dose administered (28.8-230.5 micromol/kg). 3. The amount absorbed of 14 C-clanobutin is proportional to the amount administered (28.8-230.5 micromol/kg). 4. The maximum of the accumulation of 14 C-clanobutin in the jejunal tissue is reached within the first 2 min. 5. Within 120 min 40-70% of the 14 C-clanobutin administered are excreted into bile. A concentration gradient bile/blood of nearly up to 300 is established. About 80% of the 14C-clanobutin was converted into (a) metabolite(s). 6. The highest dose of 14C-clanobutin, 230,5 micromol/kg, inhibited the absorption of glucose statistically significantly by about 60% within the first 5 min after administration. After 40 min, however, the amount of glucose adsorbed is not further reduced. The residual fluid as well as the amount of Na+-ions in the jejunal lumen is slightly increased with increasing doses of 14C-clanobutin ( dose: 57.6 and 230.5 micromol/kg), whereas the amount of K+-ions excreted into the intestinal lumen is decreased.
D000818:Animals; D001834:Body Water / Q000378:metabolism; D004573:Electrolytes / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D007408:Intestinal Absorption; D007583:Jejunum / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000378:metabolism
D004573:Electrolytes; D005680:gamma-Aminobutyric Acid; D005947:Glucose; C019159:clanobutin