[Changes in the dendrites in chronic morphine poisoning].
Ultrastructure of dendrites has been studed in lineal rats injected with hydrochloride morphine, 30 mg/kg for 20-40 days or in increasing doses from 30 up to 144 mg/kg for 40 days. The dendritic changes are manifested as focal clearance in them and decreasing number of microtubules. In the altered dendrites, swelled crest-deprived mitochondria and a small amount of micrograined material appear. In advanced stages of the dendritic changes, membranous inclusions and myelin-like bodies are revealed, often in combination with dendritic varicosities. The dendritic changes can serve as a structural prerequisite for certain disorders in receptory function of the neural cells.
D000818:Animals; D002908:Chronic Disease; D003712:Dendrites / Q000187:drug effects* / Q000648:ultrastructure; D006801:Humans; D007033:Hypothalamus, Middle / Q000187:drug effects / Q000648:ultrastructure; D008854:Microscopy, Electron; D009020:Morphine / Q000506:poisoning*; D009021:Morphine Dependence / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013003:Somatosensory Cortex / Q000187:drug effects / Q000648:ultrastructure
D009020:Morphine
Izmeneniia dendritov pri khronicheskoĭ morfinnoĭ intoksikatsii.