Vinylogous carbinolamine tumor inhibitors. 7. Tumor inhibitory agents: bis-(N-alkylcarbamate) derivatives of 2,3-dihydro-5-(3',4'-dichlorophenyl)-6,7-bis(hydroxymethyl)-1H-pyrrolizine.
A series of bis-(N-alkylcarbamate) derivatives of 2,3-dihydro-5-(3',4'-dichlorophenyl)-6,7-bis(hydroxymethyl-1H-pyrrolizine (2) were prepared and evaluated for tumor inhibitory activity (in vivo P388 leukemia.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D007941:Leukemia P388 / Q000188:drug therapy; D008297:Male; D051379:Mice; D011763:Pyrrolizidine Alkaloids / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D011763:Pyrrolizidine Alkaloids