Electroacupuncture treatment of morphine-dependent mice reduces signs of withdrawal, without showing cross-tolerance.
Morphine pellets (75 mg morphine base per pellet) were implanted subcutaneously in mice (B6AF1/J) and were surgically removed after 3 or 8 days. During morphine abstinence (7 h after pellet removal), the mice were treated with electroacupuncture (EA). The results indicate that EA analgesia shows no cross-tolerance to morphine. Additionally, EA reduced withdrawal behaviour (jumping) in 50% of the mice during morphine abstinence.
D015670:Acupuncture Therapy; D000818:Animals; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D051379:Mice; D009021:Morphine Dependence / Q000503:physiopathology*; D013375:Substance Withdrawal Syndrome / Q000517:prevention & control*