Effects of pyridoxine-pyrrolidon-carboxylate on hepatic and cerebral ATP levels in ethanol treated rats.
ATP levels were measured in the liver and brain of rats acutely intoxicated with ethanol. The pretreatment of the animals with pyridoxine-pyrrolidon carboxylate (Metadoxine) prevented the marked fall in ATP concentration caused by ethanol in both organs.
D000255:Adenosine Triphosphate / Q000032:analysis*; D000435:Alcoholic Intoxication / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D004338:Drug Combinations; D006801:Humans; D008099:Liver / Q000032:analysis* / Q000187:drug effects; D008297:Male; D011736:Pyridoxine / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D004338:Drug Combinations; D011760:Pyrrolidinones; D000255:Adenosine Triphosphate; D011736:Pyridoxine; D011761:Pyrrolidonecarboxylic Acid