Increased neurite development and plasminogen activator expression by exposure of human neuroblastoma cells to plasminogen-deficient growth medium.
Growth of human neuroblastoma strain SK-N-SH in a plasminogen-deficient medium results in about a 40% increase in the number of differentiated cells (cells with a neurite-like process at least 50 micrometers in length) and about a five-fold increase in the amount of plasminogen activator liberated per cell. Plasminogen deficiency has no effect on the growth rate of SK-N-SH cells. These results are consistent with the hypothesis that plasminogen activator is involved in neuroblast development.
D002454:Cell Differentiation; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003470:Culture Media / Q000494:pharmacology; D006801:Humans; D009374:Neoplasms, Experimental / Q000473:pathology; D009447:Neuroblastoma / Q000473:pathology*; D010958:Plasminogen / Q000172:deficiency; D010960:Plasminogen Activators / Q000378:metabolism*
D003470:Culture Media; D010958:Plasminogen; D010960:Plasminogen Activators