[Effect of long-term exposure to carbon disulfide on various biochemical indices in albino rats].
The effect of carbon sulphide was studied on sexually matured male and female albino rats, subjected to 180-day exposure with concentrations 0.03, 50 and 200 mg/m3, 6 hours daily, 5 days a week. Carbon sulphide effect was studied by indices, characterizing the state of the oxidation processes and lipid metabolism. CS2--50 and 200 mg/m3 were established to inhibit oxygen consumption of liver homogenates, better manifested in female animals, whereas in homogenates of testicles the tissue respiration was significantly inhibited only with 200 mg/m3. Some sexual discrepancies were observed in the indices of lipid metabolism, significantly changed with a concentration of 200 mg/m3. More susceptible, in male animals, proved to be the level of free fatty acids and total cholesterin, whereas in females--liver phospholipids, in all cases lower than the control group.
D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D002246:Carbon Disulfide / Q000633:toxicity*; D002784:Cholesterol / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D012737:Sex Factors; D013737:Testis / Q000378:metabolism*; D013997:Time Factors
D000393:Air Pollutants; D005227:Fatty Acids; D010743:Phospholipids; D002784:Cholesterol; D002246:Carbon Disulfide
Vliianie na produlzhitelna serovuglerodna ekspozitsiia vurkhu niakoi biokhimichni pokazateli v organi na beli plukhove.