Failure of rats deprived of water to increase food intake during glucoprivation induced by 2-deoxy-D-glucose.
Thirsty rats denied access to water did not significantly increase their food intake following the glucoprivic stimulus provided by 750 mg/kg 2-deoxy-D-glucose (2-DG). In a second study, subjects were made hypodipsic through adulteration of their water supply with 0.2% w/v quinine hydrochloride; and they too displayed glucoprivic feeding deficits at 250 mg/kg, 500 mg/kg, and 750 mg/kg dosages. A reduced ability to ingest fluids therefore can inhibit 2-DG-induced eating when rats are examined after experience with water restriction schedules. These data consequently suggest that caution may be necessary in interpreting post-lesion disruptions of 2-DG glucoprivic feeding when severe water intake deficits are also observed.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D007026:Hypothalamic Area, Lateral / Q000502:physiology; D008297:Male; D009115:Muridae; D013649:Taste / Q000187:drug effects; D014868:Water Deprivation
D001786:Blood Glucose; D003837:Deoxy Sugars; D003847:Deoxyglucose