Lack of effect of carbamazepine on gamma-aminobutyric acid in cerebrospinal fluid.
Carbamazepine was administered to nine patients with manic-depressive illness at doses ranging from 600 to 1600 mg per day, achieving blood levels between 6 and 11 microgram per milliliter. Compared to medication-free values, GABA levels in the cerebrospinal fluid (CSF) were not significantly altered by an average of 30 days' treatment with carbamazepine. These preliminary data do not support a major effect of carbamazepine on brain GABA as reflected in CSF as a mechanism for its anticonvulsant or psychotropic effects.
D000328:Adult; D001714:Bipolar Disorder / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000188:drug therapy; D002220:Carbamazepine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D005680:gamma-Aminobutyric Acid / Q000134:cerebrospinal fluid*
D002220:Carbamazepine; D005680:gamma-Aminobutyric Acid