[K+-dependent swelling of Ehrlich ascitic carcinoma cells in the presence of linoleic acid hydroperoxides and Fe2+ ions].
EFfect of linoleic acid hydroperoxide (I) and Fe++ on viscous elastic properties of cell membranes of Ehrlich ascite carcinoma was studied by the method of K+-dependent swelling. It has been shown that the action of 1 and Fe++ is of similar character, and the effect depends on the incubation time and concentration of agents in the incubation mineral solutions. After 2 h incubation the concentration relationships have two patterns characterized by increased swelling at concentrations 10(-6)-10(-5) M and inhibition of this process at concentrations above 10(-5) M. After 4 incubation only the inhibition effect of observed, which seems to reflect the increase of cell membranes rigidity conditioned by the formation of "joints" resulting from the interaction between the products of lipid peroxide oxidation and membrane macromolecules.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects*; D004548:Elasticity; D005296:Ferrous Compounds / Q000494:pharmacology*; D066298:In Vitro Techniques; D007501:Iron / Q000494:pharmacology*; D008041:Linoleic Acids / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology*; D014783:Viscosity
D005296:Ferrous Compounds; D008041:Linoleic Acids; D008054:Lipid Peroxides; C008285:linoleic acid hydroperoxide; D007501:Iron; D011188:Potassium
K+-zavisimoe nabukhanie kletok astsitnoĭ kartsinomy Erlikha v prisutstvii gidroperekiseĭ linolevoĭ kisloty i ionov Fe2+.