Elevated platelet-bound IgG associated with an episode of thrombotic thrombocytopenic purpura.
The level of platelet-associated IgG (PAIgG) were measured during the successful treatment of a patient with thrombotic thrombocytopenic purpura. Prior to therapy. PAIgG was found to be markedly elevated to 195 fg/cell (normal range 0--3.5 fg/cell). The institution of combined therapy with intensive plasma exchange transfusions, high-dose steroids, and antiplatelet drugs resulted in a complete recovery and a decline in PAIgG to the normal range. The possible role of platelet antibody in the pathogenesis of this disorder is discussed.
D001241:Aspirin / Q000627:therapeutic use; D001792:Blood Platelets / Q000276:immunology*; D004176:Dipyridamole / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D008875:Middle Aged; D010951:Plasma Exchange; D010976:Platelet Count; D011241:Prednisone / Q000627:therapeutic use; D011697:Purpura, Thrombotic Thrombocytopenic / Q000188:drug therapy / Q000276:immunology*
D007074:Immunoglobulin G; D004176:Dipyridamole; D001241:Aspirin; D011241:Prednisone