Thioproline: an inhibitor of chemical carcinogenesis.
Experimental DBA/1 mice were implanted with methylcholanthrene impregnated filterpaper disks. The disks were removed six weeks after implantation and median induction of fibrosarcomas occurred in 114.5 +/- 6 days. Two weeks pretreatment with thioproline, a reverse transformation drug, followed by maintenance throughout the duration of the experiment (27 weeks) reduced the tumor incidence to 60% that of controls. Pretreatment with thioproline and drug administration continued only through the six weeks post-implantation period failed to alter tumor incidence.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D005260:Female; D008748:Methylcholanthrene; D051379:Mice; D008811:Mice, Inbred DBA; D009374:Neoplasms, Experimental / Q000517:prevention & control*; D013844:Thiazoles / Q000494:pharmacology / Q000627:therapeutic use*; D053778:Thiazolidines
D000970:Antineoplastic Agents; D013844:Thiazoles; D053778:Thiazolidines; D008748:Methylcholanthrene; C003438:thiazolidine-4-carboxylic acid