[Antibacterial activity of co-trimoxazole and tetroxoprim/sulfadiazine in vitro (author's transl)].
The antibacterial activity of the newly developed combination, tetroxoprim/sulfadiazine, was evaluated and compared with that of the combination, trimethoprim/sulfamethoxazole. Tested strains were: Klebsiella pneumoniae, Proteus vulgaris, Proteus mirabilis, and Streptococcus faecalis. The components in both combinations were assayed in different ratios on a weight basis and activities measured as minimum inhibitory and minimum bactericidal concentrations employing serial dilution tests in Isosensitest bouillon in microtiter plates. It was found that the combination tetroxoprim/sulfadiazine acts synergistically -- as does the combination trimethoprim/sulfamethoxazole -- optimal antibacterial activities being achieved with a weight ratio benzylpyrimidine/sulfonamide of 1:1 or 1:5, respectively. In all instances, the combination trimethoprim/sulfamethoxazole proved to be of higher antibacterial in vitro activity than that of tetroxoprim/sulfadiazine.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004338:Drug Combinations; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000494:pharmacology*; D013411:Sulfadiazine / Q000494:pharmacology*; D013420:Sulfamethoxazole / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D011743:Pyrimidines; D013411:Sulfadiazine; C023507:tetroxoprim; D014295:Trimethoprim; D013420:Sulfamethoxazole
Antibakterielle Aktivität von Trimethoprim/Sulfamethoxazol (Co-trimoxazol) und Tetroxoprim/Sulfadiazin in vitro.