A peculiar toxicity manifested by platinum(II)amines in rats: gastric distension after intraperitoneal administration.
Metoclopramide i.p. reduces the gastric distension consistently seen in rats given cisplatin i.p. at effective immunosuppressant doses (6 mg/kg). Many other immunosuppressant/oncolytic platinum amines also engendered gastric distension but certain dimers and 1,2-cyclohexanediaminoplatinum (II) compounds did not. This phenomenon appears to be due to paralysis of gastric emptying (without appetite suppression).
D000818:Animals; D002945:Cisplatin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000633:toxicity*; D005260:Female; D013271:Gastric Dilatation / Q000139:chemically induced* / Q000188:drug therapy; D007274:Injections, Intraperitoneal; D008787:Metoclopramide / Q000627:therapeutic use; D051381:Rats
D008787:Metoclopramide; D002945:Cisplatin