Vertical transmission of acquired ulcer susceptibility in the rat.
Premature separation of rat pups from their dams greatly increases their susceptibility to restraint-induced gastric erosions. When prematurely separated female rats grow to adulthood and mate with stock males, their normally reared F 1 progeny also have increased susceptibility to restraint-induced erosions. Cross-fostering studies show that prenatal rather than postnatal factors transmit this susceptibility to the F 1 progeny.
D000818:Animals; D000833:Animals, Suckling / Q000502:physiology; D005260:Female; D006801:Humans; D008425:Maternal Behavior; D011247:Pregnancy; D051381:Rats; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000196:embryology / Q000209:etiology / Q000235:genetics*; D013315:Stress, Psychological / Q000150:complications*