The mechanism of the antagonism by naloxone of acute alcohol intoxication.
Naloxone lowers blood-ethanol concentration and causes a simultaneous reversal of the disturbances in the redox states of the hepatic nicotinamide-adenine dinucleotide (phosphate) couples in acutely-ethanol-intoxicated rats. It is suggested that these effects of naloxone form the basis of its antagonism of acute alcohol intoxication.
D000208:Acute Disease; D000435:Alcoholic Intoxication / Q000517:prevention & control*; D000818:Animals; D000431:Ethanol / Q000378:metabolism; D006801:Humans; D008297:Male; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009243:NAD; D009270:Naloxone; D000431:Ethanol; D009249:NADP