Ethanol intoxication as a function of genotype dependent responses in three inbred mice strains.
Three strains of mice, ICR Swiss, DBA/2J and C57Bl/6J were compared for initial sensitivity, recovery from intoxication, and acute tolerance development to ethanol. The The C57Bl/6J mice were found to be less sensitive and to recover more rapidly from the effects of the same dose of ethanol than the other two strains treated. None of the strains tested demonstrated acute tolerance to ethanol when given the same dose 3 hours later.
D000437:Alcoholism / Q000235:genetics*; D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics; D008811:Mice, Inbred DBA / Q000235:genetics; D008813:Mice, Inbred ICR / Q000235:genetics; D008815:Mice, Inbred Strains / Q000235:genetics*; D013045:Species Specificity
D000431:Ethanol