title: Prothrombin Gainesville. A dysprothrombinemia in a pair of identical twins.
abstract: A pair of identical twins was evaluated for menometrorrhagia and mild post-operative bleeding. Each had a slightly prolonged partial thromboplastin time and prothrombin time. Full hemostatic evaluation was normal, except that plasma prothrombin activity was 23% and 25% of normal with a Russell's viper venom assay. Each twin had 70% of normal plasma prothrombin antigen. Prothrombin kinetic data were obtained before and during hysterectomy. In these twins, infused prothrombin (Konyne) was found to have a volume of distribution of approximately one and one-half times the plasma volume and a half-life of 34 hours. The previously reported dysprothrombins are briefly reviewed. Prothrombin Gainesville is the twelfth such disorder reported.
mesh_terms: D000328:Adult; D004200:Diseases in Twins / Q000097:blood / Q000151:congenital*; D005260:Female; D005431:Florida; D006487:Hemostasis; D006801:Humans; D007020:Hypoprothrombinemias / Q000097:blood / Q000150:complications / Q000151:congenital*; D007044:Hysterectomy; D008796:Metrorrhagia / Q000097:blood / Q000150:complications; D010375:Pedigree; D011247:Pregnancy; D011516:Prothrombin / Q000276:immunology; D014427:Twins; D014430:Twins, Monozygotic
chemical_list: D011516:Prothrombin