[Human i.v. immune globulin by chemical modification with beta-propiolactone/radiochemical study (author's transl)].
Elimination of anticomplementary activity of human immune globulin G (IgG, Intraglobin) is achieved by introduction of 6 OH-propionic groups per IgG-molecule. These groups introduced by modification with beta-propiolactone, are equally spread out on the molecule and situated at lysin.
D003167:Complement Activation / Q000187:drug effects; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007263:Infusions, Parenteral; D007783:Lactones / Q000494:pharmacology*; D011420:Propiolactone / Q000494:pharmacology*
D007074:Immunoglobulin G; D007783:Lactones; D011420:Propiolactone
Intravenöses Human-Immunglobulin durch chemische Modifizierung mit beta-Propiolacton. Radiochemische Untersuchungen.