title: [Human pharmacokinetics of theophylline and etofylline from different formulations of a cardiotonic (author's transl)].
abstract: Serum concentrations of theophylline and etofylline were analysed by a specific HPLC-method in 6 volunteers after i.v. and p.o. administration of the cardiotonic Cordalin ampoules, drops and dragees. Maximum serum concentrations were reached by theophylline an etofylline at about the same time: 1.0-1.2 h after Cordalin drops; 2.3-2.6 h after Cordalin dragees. The half-life of serum elimination was 5.0-7.2 h for theophylline and 5.5-6.9 h for etofylline. The absolute bioavailability of the two oral formulations was calculated from the areas under the serum curves. For theophylline it is complete from the dragees and 78% from drops. Etofylline, too, is highly bioavailable: 94% from the dragees, 84% from drops. From the kinetic data the conclusion can be drawn that accumulation of theophylline and etofylline will be negligible after Cordalin if administered according to prescribed directions.
mesh_terms: D000284:Administration, Oral; D001682:Biological Availability; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000378:metabolism*; D004338:Drug Combinations; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D013806:Theophylline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood*
chemical_list: D002316:Cardiotonic Agents; D004338:Drug Combinations; D013806:Theophylline; C008749:etofylline
vernacular_title: Zur Humanpharmakokinetik von Theophyllin und Etofyllin aus verschiedenen Zubereitungen eines Kardiotonikums.