[Change of relative bioavailability of riboflavin by the fluid intake (author's transl)].
Administration of 6,7-dimethyl-9-(D-1-ribityl)-isoalloxazine (riboflavin) solution (30 mg/200 ml) dissolved in a fruit juice to 5 volunteers resulted in increased relative bioavailability between 156 and 246% compared to the intake with water. The reason should be the delayed gastric emptying rate due to the osmotic pressure and the acidity of the juice.
D000328:Adult; D001682:Biological Availability; D004304:Dosage Forms; D005260:Female; D005638:Fruit; D005746:Gastric Emptying / Q000187:drug effects; D006801:Humans; D008297:Male; D009997:Osmotic Pressure; D010936:Plant Extracts / Q000494:pharmacology*; D012256:Riboflavin / Q000378:metabolism*
D004304:Dosage Forms; D010936:Plant Extracts; D012256:Riboflavin
Beeinflussung der relativen Bioverfügbarkeit von Riboflavin durch eine Einnahmeflüssigkeit.