Chromosome abnormalities in 150 couples with multiple spontaneous abortions.
One hundred fifty consecutive couples with recurrent abortions with or without fetal deaths, malformations, or healthy infants were evaluated cytogenetically with a G-band method. Seven couples (4.7%) showed a chromosome aberration in one partner (5 translocations, 1 inversion, and 1 gonosomal mosaicism). Of the couples with a pure abortion history, 2.9% had a chromosomal abnormality. A high incidence of chromosomal rearrangements in the groups of couples with abortions plus fetal deaths or malformations was found. In contrast to other reports, a high incidence of cytogenetic abnormalities was also found in couples with abortions and healthy infants. Chromosome analysis is advocated as a primary tool in the evaluation of couples with repetitive fetal wastage.
D000026:Abortion, Habitual / Q000235:genetics*; D002869:Chromosome Aberrations / Q000235:genetics*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D007446:Chromosome Inversion; D002904:Chromosomes, Human, 21-22 and Y; D005260:Female; D006801:Humans; D008297:Male; D009030:Mosaicism; D011247:Pregnancy; D014178:Translocation, Genetic