[Lysolecithin and stress ulcers in rats].
The effect of lysolecithin on gastric mucosa in rats has been investigated using a new operative model. Ten rats underwent sham-laparotomy. In 4 other groups, each of 10 animals, the rats underwent pyloro-jejunostomy and Roux-en-Y anastomosis. 9 of 10 rats operated upon in this way, and given a solution of lysolecithin to drink before administration of restraint stress, produced stress ulcers. However, only 3 of 10 animals given Ringer-solution produced minor mucosal defects. Lysolecithin not combined with stress had no noteworthy deleterious effect on gastric mucosa either in sham-operated rats or in those with our operation model. Thus, lysolecithin combined with stress in our model performed an important function in the pathogenesis of stress lesions. Lysolecithin is produced in considerable quantities during fat metabolism in the intestine, and may be regurgitated together with duodenal contents into the stomach.
D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D008244:Lysophosphatidylcholines / Q000633:toxicity*; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology*; D013315:Stress, Psychological / Q000150:complications*
D008244:Lysophosphatidylcholines
Lysolecithin und Stressulkuks bei der Ratte.