Increased fetal heart rate variability with acute hypoxia in chronically instrumented sheep.
Fetal heart rate (FHR) and oxygen consumption were determined in 45 studies in 20 chronically instrumented, normoxic sheep. FHR variability was measured by a template device to determine amplitude range, and oscillatory frequency was manually counted over 5-min periods. During 26 min of isocapnic hypoxia, fetal O2 consumption decreased 39% and FHR decreased 18%, and FHR variability increased, the changes being maintained over the treatment period. It is suggested that the maintenance of FHR variability during this profound hypoxia denotes adequate cardiorespiratory compensatory mechanisms during the short period; prolongation of the hypoxia would probably result in fetal cerebral or myocardial decompensation, and disappearance of FHR variability. The increased variability may be due to increased alpha-adrenergic activity.
D000818:Animals; D005260:Female; D005318:Fetal Heart / Q000503:physiopathology*; D005311:Fetal Hypoxia / Q000503:physiopathology*; D005323:Fetal Monitoring; D006339:Heart Rate; D010101:Oxygen Consumption; D011247:Pregnancy; D012756:Sheep