Oligodendrocyte-binding antibodies in multiple sclerosis: 125I-protein A studies.
Sera from patients with multiple sclerosis (MS), patients with neurologic diseases other than MS, controls (adult and newborn), and rabbits immunized with bovine oligodendrocytes were assayed for antioligodendrocyte antibodies by a binding test with 125I-protein A. The mean binding of 125I-protein A to oligodendrocytes was similar in MS and non-MS sera, but both were significantly higher than binding in controls. A hundredfold increase of 125I-protein A binding over the preimmune value was obtained with a rabbit antioligodendrocyte antiserum. Oligodendrocyte-binding antibodies measured with 125I-protein A do not appear to be a distinctive feature of MS.
D000328:Adult; D000818:Animals; D001666:Binding Sites, Antibody; D002417:Cattle; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007231:Infant, Newborn; D007457:Iodine Radioisotopes; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology*; D009457:Neuroglia / Q000276:immunology*; D009836:Oligodendroglia / Q000276:immunology*; D011817:Rabbits; D011863:Radioimmunoassay / Q000379:methods*; D013205:Staphylococcal Protein A
D007074:Immunoglobulin G; D007457:Iodine Radioisotopes; D013205:Staphylococcal Protein A