[Neurophysiologic and pharmacologic evidence of autoregulationin the nigrostriatal system].
Repeated electrical stimulation of substantia nigra in cats produces a progressive relaxation of the poststimulation stereotyped behavior. This effect may be consequent on the development of autoinhibition in the nigro-striatal pathways since the rate of stereotypy inhibition increases in the presence of low doses of amphetamine and apomorphine but is reduced by little doses of haloperidol. A possible reason for autoinhibition is likely to involve an activation of the presynaptic dopaminergic receptors on nigro-striatal axons.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002415:Cats; D003342:Corpus Striatum / Q000502:physiology*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D006706:Homeostasis; D006801:Humans; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D011954:Receptors, Dopamine / Q000502:physiology*; D013239:Stereotyped Behavior / Q000187:drug effects / Q000502:physiology*; D013378:Substantia Nigra / Q000502:physiology*
D011954:Receptors, Dopamine; D000661:Amphetamine; D006220:Haloperidol; D001058:Apomorphine
Neĭrofiziologicheskie i farmakologicheskie dokazatel'stva samoreguliatsii v nigro-striatnoĭ sisteme.