Interaction of AR-L 115 BS with isoprenaline on hemodynamic parameters in the isolated guinea pig heart.
The effects 2-[(2-methoxy-4-methylsulfinyl)phenyl]-1H-imidazo[4,5-b]pyridine (AR-L 115 BS) and isoprenaline on some hemodynamic parameters of a stable isolated heart preparation from guinea pigs were studied. In the ventricular myocardium, AR-L 115 BS potentiated the inotropic effect of isoprenaline (8 x 10(-10) mol/l) in a dose dependent manner. The influence of AR-L 115 BS on heart rate in the presence and absence of isoprenaline was rather small. The possible role of catecholamines in modifying the effect of AR-L 115 BS is emphasized.
D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects; D004347:Drug Interactions; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D007093:Imidazoles / Q000494:pharmacology*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism
D002316:Cardiotonic Agents; D007093:Imidazoles; C029758:sulmazole; D007545:Isoproterenol