title: Combined vitamin A and E therapy prevents retinal electrophysiological deterioration in abetalipoproteinaemia.
abstract: Eight patients with abetalipoproteinaemia had the typical ocular, systemic, and laboratory findings of this disease. Combined therapy with vitamins A and E was administered, starting as early as the first day of life and as late as 26 years of age. The patients were followed up for 2-6 years. Electroretinography was undertaken in all cases and electrooculography in some. After initiation of vitamin A and E therapy no progression of disturbed visual function could be detected in any patient. These objective tests of retinal function demonstrated that the combined vitamin A and E therapy may be useful in arresting retinal deterioration in abetalipoproteinaemia.
mesh_terms: D000012:Abetalipoproteinemia / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004585:Electrooculography; D004596:Electroretinography; D006801:Humans; D007223:Infant; D012162:Retinal Degeneration / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D014801:Vitamin A / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D014801:Vitamin A; D014810:Vitamin E