title: [Rational substitution therapy in blood coagulation disorders].
abstract: Indications and possible side effects of clotting factor concentrates are reviewed. Although clotting factor concentrates are natural products, their side effects can not be neglected. When using clotting factor concentrates the risk/benefit ratio has to be always considered.
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology; D001778:Blood Coagulation Disorders / Q000628:therapy*; D001779:Blood Coagulation Factors / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D013927:Thrombosis / Q000209:etiology; D014018:Tissue Distribution
chemical_list: D001779:Blood Coagulation Factors
vernacular_title: Rationelle Substitutionstherapie bei Gerinnungsstörungen.