title: Correlations between relatives for acrocentric association frequency.
abstract: Acrocentric association was investigated in peripheral blood lymphocytes of twins (10 female monozygotic and 11 females dizygotic pairs), newborns and both parents (30 families), and spouses (51 pairs). Seventy two hour cultures were G-banded and scored for both absolute and relative acrocentric association frequency, except in the case of the spouse pairs where only the absolute frequency was measured. Both relative and absolute parameters of acrocentric association show positive correlations between relatives with the values being highest and most consistent in monozygotic twins, intermediate in parent and offspring, and most variable in dizygotic twins. Husband and wife pairs from our family collections show a positive correlation for the absolute parameter but not for relative parameters. The environmental factors responsible have not been identified. A rough estimate of broad sense heritability (0.81) has been made for the relative parameters. It probably contains a large component due to genetic dominance. Heritability of the absolute parameters is probably lower than for the relative parameters though estimation of its value is complicated by inconsistent results. A model is proposed to account for the variation in satellite association frequency which contains two elements: (i) The genotype determines the ratio of one chromosome type to another in the population of associated chromosomes (ii) All other environmental factors influence the absolute frequency of association without altering this basic ratio.
mesh_terms: D000328:Adult; D001399:Azure Stains; D002478:Cells, Cultured; D002871:Chromosome Banding; D002877:Chromosomes, Human / Q000648:ultrastructure*; D004276:DNA, Satellite; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D009690:Nucleic Acid Conformation; D011247:Pregnancy; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
chemical_list: D001399:Azure Stains; D004276:DNA, Satellite