[Studies on chemotherapy of parasitic helminths (III). Effects of tuberostemonine from Stemona japonica on the motility of parasitic helminths and isolated host tissues (author's transl)].
Effects of tuberostemonine (TS), an alkaloid from Stemona japonica, on the motility of parasitic helminths and isolated frog rectus and mouse ileum were studied. 1) TS (6.7 X 10(-6) approximately 2 X 10(-5) M) paralyzed the motility of Angiostrongylus cantonensis. 2) TS (6.7 X 10(-5) M) showed contractive effects on the motility of Dipylidium caninum and Fasciola hepatica. 3) Treatment with TS (6.7 X 10(-5) approximately 4.8 X 10(-4) M) had little effect on the motility of Schistosoma japonicum. 4) TS (6.7 X 10(-5) M) paralyzed the motility of the mouse isolated ileum preparation. 5) TS (6.7 X 10(-7) 6.7 X 10(-6) M) stimulated the twitch response induced by guanidine (2.5 X 10(-3) M) in the frog isolated rectus preparation. 6) Eserine and TS acted antagonistically on all preparations with the the exception of S. japonicum. 7) TS and strychnine were antagonistic in isolated host tissues, whereas these compounds acted similarly on parasitic helminths. Thus, it is suggested that some of the experiential effects of the crude extracts of Stemona such as the anthelmintic effects are caused through the action of TS on parasitic helminths and host tissues.
D000470:Alkaloids / Q000494:pharmacology*; D000801:Angiostrongylus / Q000187:drug effects; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D002589:Cestoda / Q000187:drug effects; D005210:Fasciola hepatica / Q000187:drug effects; D006376:Helminths / Q000187:drug effects*; D007082:Ileum / Q000469:parasitology; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009068:Movement / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000032:analysis; D011898:Ranidae; D012007:Rectum / Q000469:parasitology; D012549:Schistosoma japonicum / Q000187:drug effects
D000470:Alkaloids; D000871:Anthelmintics; D010936:Plant Extracts; C034243:tuberostemonine