title: [The diagnostic relevance of the aminopyrine breath test in liver disease].
abstract: Aminopyrine breath test was investigated in 268 patients with various liver disease. From the specific activity for six hours after ingestion of a tracer dose the elimination rate in percent per hour is calculated. Comparing to 47 controls the elimination rate is reduced about 20% in patients with chronic persistent hepatitis (49 patients) and fatty liver (84 patients). In 42 patients with chronic active hepatitis the elimination rate is reduced to 48% and in 54 patients with cirrhosis to 64%. Between aminopyrine breath test and indocyaningreen test or cholinesterase and albumin no correlations were found. Aminopyrine breath test is a sensitive, non-invasive test and specific in liver function and therefore useful in the follow up of patients with known liver disease.
mesh_terms: D000632:Aminopyrine; D001711:Biotransformation; D001944:Breath Tests / Q000379:methods*; D002779:Cholestasis / Q000175:diagnosis; D005234:Fatty Liver / Q000175:diagnosis; D005260:Female; D006505:Hepatitis / Q000175:diagnosis; D006521:Hepatitis, Chronic / Q000175:diagnosis; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis; D008107:Liver Diseases / Q000175:diagnosis*; D008111:Liver Function Tests; D008297:Male
chemical_list: D000632:Aminopyrine
vernacular_title: Zur diagnostischen Relevanz des Aminopyrin-Atemtests bei Lebererkrankungen.