In vitro inhibition of rat serum complement activity by an extract of lyophilised human dura mater.
The inhibiting effects of an extract of lyophilised human dura mater on the complement activity of rat serum have been studied in order to evaluate a possible species-specific antigenic activity in this material generally used in the repair of dural defects. The results demonstrated that the extract may inhibit complement activity of rat serum. The phenomenon resulted to be of low entity (nearly 20% of mean value) and was due to the interaction between tissue species-specific antigens and natural antibodies of rat serum. The residual antigenic activity may limit the use of this material only in xenogeneic graft recipients.
D000818:Animals; D003169:Complement Inactivator Proteins / Q000032:analysis*; D004388:Dura Mater / Q000032:analysis*; D005612:Freeze Drying; D006801:Humans; D051381:Rats; D013045:Species Specificity
D003169:Complement Inactivator Proteins