The influence of I.V. application of pentoxifylline on the viscoelasticity of blood in patients with peripheral vascular disorders.
Viscoelastic parameters of blood from 9 patients with vascular disorders before and at different time intervals after POF infusion were investigated. There was a significant decrease in both parameters up to 1h after the end of POF application. Parallel measurements of hematocrit, density of whole blood and plasma, and particle volume distribution of RBC's would suggest that this drug reduces the enhanced aggregation tendency of RBC present in most pathological conditions.
D000368:Aged; D001157:Arterial Occlusive Diseases / Q000097:blood*; D001809:Blood Viscosity / Q000187:drug effects*; D004548:Elasticity; D005260:Female; D006400:Hematocrit; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010431:Pentoxifylline / Q000494:pharmacology*; D013805:Theobromine / Q000031:analogs & derivatives*
D013805:Theobromine; D010431:Pentoxifylline