[Antitumor effect of a water-in-oil-in-water type adriamycin emulsion on Ehrlich solid tumor-bearing mice].
Antitumor effect of water-in-oil-in-water type adriamycin emulsion (emulsion ADM) was examined in comparison with free ADM on the survival time of ICR male mice bearing Ehrlich solid tumor after a subcutaneous inoculation and on the tumor growth by the subcutaneous (SC-SC) or intraperitoneal administration (SC-IP). In the SC-SC system at the dose of 0.2 mg/kg or 1.0 mg/kg, the mice administered with the emulsion ADM (emulsion ADM group) showed prolonged survival time and stronger inhibitory effect of the tumor growth than free ADM group, and at 1.0 mg/kg, showed statistically significant different inhibition of the tumor growth from free ADM group. Moreover, at 5.0 mg/kg which dose come to manifest the subacute toxicity, emulsion ADM group showed a statistically significant different prolongation of the mean survival time from free ADM group. In the SC-IP system at the dose of 0.2 mg/kg or 1.0 mg/kg, emulsion ADM group showed a prolonged mean survival time than free ADM group. From these results, it is considered that entrapment of ADM into emulsion reduces the subacute toxicity of the mouse and increases the antitumor effect of the drug against Ehrlich solid tumor.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000009:adverse effects; D004655:Emulsions; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009821:Oils; D014867:Water
D004655:Emulsions; D009821:Oils; D014867:Water; D004317:Doxorubicin