Site dependent response of tumours to combined heat and radiation.
In previous experiments, large differences in thermal sensitisation were observed for tumours grown on the tails of the chest of mice. The present work reports the results of experiments to compare the response of tumours in four different sites to the radiosensitising effects of both heat and misonidazole. Factors influencing tumour response, e.g., tumour growth rate, blood flow, temperature uniformity, temperature increase during heating and drug availability, were also studied. Tumour response and most of the parameters measured varied according to the site of tumour implantation. Growth rate, blood flow and natural tumour temperature are all likely to be important. However, there appears to be no simple relationship by which tumour response could be predicted, although heat dose, the product of temperature elevation above the natural level and treatment time, may be the most relevant parameter. Clearly the choice of implant site does influence response to treatment. Tumours grown on the extremities may be poor models for human tumours, because of their low natural temperatures.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005528:Foot; D006614:Hindlimb; D006358:Hot Temperature / Q000627:therapeutic use*; D051379:Mice; D008808:Mice, Inbred CBA; D008920:Misonidazole / Q000627:therapeutic use; D009368:Neoplasm Transplantation; D012039:Regional Blood Flow; D012513:Sarcoma, Experimental / Q000098:blood supply / Q000532:radiotherapy*; D012983:Soft Tissue Neoplasms / Q000098:blood supply / Q000532:radiotherapy*; D013623:Tail; D013696:Temperature; D013909:Thorax
D008920:Misonidazole