[Cellular sites of action and effects of drugs. A review (author's transl)].
Due to the fact that they are used consciously to achieve positive effects on diseases in man, drugs occupy a special position among the large number of substances that affect the cellular structure and function. In view of the basic similarity and/or parallelism of the structural composition and of the metabolic processes of healthy and diseased cells, one can expect effects on the diseased cell and side-effects on healthy cells to form a unity. The aim of any therapy should be to keep the distance between the positive effect and the side-effect as great as possible, which should be examined and carefully weighed in each case. An attempt is made in the present review to examine by giving some examples the problems involved in the cellular effects of drugs and to explain their action. New therapeutic effects can be found and put to use by knowing the cellular site of action.
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D002466:Cell Nucleolus / Q000187:drug effects; D002477:Cells / Q000187:drug effects*; D003599:Cytoskeleton / Q000187:drug effects; D064420:Drug-Related Side Effects and Adverse Reactions; D007758:Ear, Inner / Q000187:drug effects; D004721:Endoplasmic Reticulum / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008247:Lysosomes / Q000187:drug effects; D008870:Microtubules / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects; D051381:Rats
Zelluläre Angriffspunkte und Wirkungen von Pharmaka. Ubersicht.