A crossover study comparing the kinetics of Tc-99m-labeled diethyl- and diisopropyl-IDA.
Tc-99m-diisopropyl-IDA (DISIDA) and Tc-99m-diethyl-IDA (DE-IDA) were compared in each of 44 patients who had serum bilirubin levels ranging from normal to 50 mg/dl. Quantitative and qualitative analysis showed a significantly higher liver uptake relative to background for DISIDA. No significant differences between DISIDA and DE-IDA were found in the blood retention and rate of liver washout. Clinically, the diagnostic information received from both radiopharmaceuticals was essentially the same.
D000328:Adult; D000368:Aged; D001660:Biliary Tract Diseases / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D006932:Hyperbilirubinemia / Q000150:complications; D007098:Imino Acids / Q000097:blood / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism; D008107:Liver Diseases / Q000000981:diagnostic imaging / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013667:Technetium / Q000097:blood / Q000378:metabolism*; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid; D019785:Technetium Tc 99m Disofenin
D007098:Imino Acids; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid; D013667:Technetium; D019785:Technetium Tc 99m Disofenin