title: Bioavailability of plafibride in healthy volunteers.
abstract: The pharmacokinetics of N-2-(p-chlorophenoxy)-isobutyryl-N'-morpholinomethylurea (plafibride, ITA 104) in rats, and its intestinal absorption, plasmatic biotransformation, urinary elimination and fecal excretion were previously studied. 1200 mg of plafibride orally were administered to 5 healthy volunteers and then the presence of the drug and its metabolites was studied in the serum. The presence of unchanged plafibride and clofibric acid was detected, whereas that of 2-(p-chlorophenoxy) isobutyrylurea was not. At the same time the platelet antiaggregating activity of plafibride was investigated in the 5 volunteers. In this study plafibride presented a good and long-lasting platelet antiaggregating activity.
mesh_terms: D000328:Adult; D001682:Biological Availability; D002994:Clofibrate / Q000031:analogs & derivatives*; D002995:Clofibric Acid / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects
chemical_list: D002995:Clofibric Acid; C016894:plafibride; D002994:Clofibrate