title: The effects of fibronectin on the adhesion and migration of chinese hamster ovary cells on collagen substrata.
abstract: Data are presented indicating that the adhesion of Chinese hamster ovary cells (CHO) to films of denatured type I collagen occurs by a fibronectin-dependent mechanism, whereas the adhesion of these cells to 3-dimensional gels of native type I collagen fibres may occur by either a rapid, fibronectin-dependent mechanism or by a slower, fibronectin-independent mechanism, whereas the adhesion of these cells to 3-dimensional gels of native type I collagen fibres may occur by either a rapid, fibronectin-dependent mechanism or by a slower, fibronectin-independent mechanism. Data are also presented indicating that fibronectin promotes the migration of CHO cells on native type I collagen fibres.
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects*; D003094:Collagen; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D005353:Fibronectins / Q000494:pharmacology*; D010053:Ovary / Q000166:cytology
chemical_list: D005353:Fibronectins; D003094:Collagen