An evaluation of the diurnal rhythm of urea excretion in healthy young adults.
A diurnal variation in urine urea excretion has been documented to exist in healthy young adults. Its persistence when dietary nitrogen intake approaches zero suggests that influences other than diet may in part generate the rhythm. These may include variations in the efficiency of rates of endogenous protein turnover of perhaps changes in renal tubular handling of urea especially in states of dietary nitrogen inadequacy. Recognition of these effects in the normal state are important before ascribing importance to changes in the disease state, particularly as we gain the ability to intervene nutritionally in the hospital setting.
D000328:Adult; D002940:Circadian Rhythm; D003404:Creatinine / Q000652:urine; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007684:Kidney Tubules / Q000502:physiology; D008297:Male; D009584:Nitrogen / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D014508:Urea / Q000652:urine*
D004044:Dietary Proteins; D011506:Proteins; D014508:Urea; D003404:Creatinine; D009584:Nitrogen