Gonadal dysgenesis with mosaicism and a nonfluorescent Y chromosome: report of two cases with correlation of clinical, pathologic, and cytogenetic findings.
Two phenotypic girls with nonfluorescent Y chromosome mosaicism and histologic streak gonads were presented. H-Y antigen (a Y chromosome--determined antigen) was negative in both patients. Electron microscopic findings of "streak gonads" were presented for the first time. The authors recommend bilateral gonadectomy in patients with nonfluorescent Y chromosomes and correlation between the histologic findings and H-Y antigen status.
D000293:Adolescent; D003878:Dermatoglyphics; D004912:Erythrocytes / Q000648:ultrastructure; D005260:Female; D006059:Gonadal Dysgenesis / Q000097:blood / Q000235:genetics* / Q000473:pathology; D006182:H-Y Antigen / Q000032:analysis; D006801:Humans; D007621:Karyotyping; D008297:Male; D009030:Mosaicism; D010053:Ovary / Q000648:ultrastructure; D010641:Phenotype; D012730:Sex Chromosomes / Q000473:pathology*; D014998:Y Chromosome / Q000473:pathology*
D006182:H-Y Antigen