Dysfunctional plasminogen in full-term newborn.
Full-term newborns (FTN) plasminogen was evaluated by different techniques (affinity chromatography, immunologic technique, casein method, and chromogenic substrate). The functional activity of the FTN plasminogen was about 50% of that of the adult. This suggests the possible existence of a functional anomaly of plasminogen in FTN. FTN plasminogen aminoacids were studied, and, besides small qualitative anomalies, a decrease in amino acid residues per mole of protein and a different N-terminal amino acid were detected.
D000328:Adult; D000596:Amino Acids / Q000032:analysis; D000933:Antifibrinolytic Agents / Q000032:analysis; D002364:Caseins; D002863:Chromogenic Compounds; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007231:Infant, Newborn; D007700:Kinetics; D010958:Plasminogen / Q000032:analysis*; D010960:Plasminogen Activators; D013300:Streptokinase
D000596:Amino Acids; D000933:Antifibrinolytic Agents; D002364:Caseins; D002863:Chromogenic Compounds; D010958:Plasminogen; D013300:Streptokinase; D010960:Plasminogen Activators