Ethanol and acetaldehyde do not increase the blood-brain and blood-retinal barrier permeability to sodium fluorescein.
No extravasation of sodium fluorescein from capillaries of the cerebral cortex and retina could be demonstrated in rats during severe nonlethal ethanol and/or acetaldehyde poisoning. The results do not exclude the possibility that repeated intoxications may gradually open the blood-brain and blood-retinal barriers, but do indicate the absence of an effect during acute intoxication.
D000079:Acetaldehyde / Q000633:toxicity*; D000435:Alcoholic Intoxication / Q000378:metabolism; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D000431:Ethanol / Q000633:toxicity*; D019793:Fluorescein; D005452:Fluoresceins / Q000378:metabolism; D006801:Humans; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000378:metabolism*; D012171:Retinal Vessels / Q000378:metabolism*
D005452:Fluoresceins; D000431:Ethanol; D000079:Acetaldehyde; D019793:Fluorescein