Studies of the intestinal transfer of coumarin and 7-hydroxycoumarin across guinea pig and rat small intestine.
The mechanism in the intestinal absorption of coumarin and 7-hydroxycoumarin were studied using the in vitro everted and non-everted gut of guinea pigs and rats. The results of the experiments indicated that both coumarin and 7-hydroxycoumarin are absorbed by the passive drug-transfer process. The presence of probenecid/KCN increased the amount of drug transferred across the gut. The mechanism of the latter compounds on the drug-transfer process is still not clear.
D000818:Animals; D003374:Coumarins / Q000378:metabolism*; D006168:Guinea Pigs; D007408:Intestinal Absorption / Q000187:drug effects; D011190:Potassium Cyanide / Q000494:pharmacology; D011339:Probenecid / Q000494:pharmacology; D051381:Rats; D014468:Umbelliferones / Q000378:metabolism*
D003374:Coumarins; D014468:Umbelliferones; D011190:Potassium Cyanide; D011339:Probenecid