O-esters of N-acylhydroxylamines: toxicity and enhancement of sister-chromatid exchange in Chinese hamster ovary cells.
2-Naphthohydroxamic acid, 4-n-butoxyphenylacetohydroxamic acid, and their O-sulfonate, O-formate, O-acetate, and O-propionate derivatives were studied for cytotoxicity and sister chromatid exchange (SCE) induction in Chinese hamster ovary (CHO) cells. 2-Naphthylisocyanate, 2-aminonaphthalene (2 Lossen rearrangement products of the O-sulfonate derivative of 2-naphthohydroxamic acid), and N-methyl-2-naphthohydroxamic acid were also studied. All of these chemicals were cytotoxic and significantly increased SCE frequency, although there was a lack of correlation between these 2 effects. 2-naphthylisocyanate and 2-aminonaphthalene were not as cytotoxic nor as active in inducing SCEs as the O-sulfonate ester of 2-naphthohydroxamic acid suggesting that the cytotoxicity and SCE induction of the latter are not due to its decomposition products.
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D006224:Cricetinae; D003412:Cricetulus; D003434:Crossing Over, Genetic / Q000187:drug effects*; D005260:Female; D006898:Hydroxylamines / Q000494:pharmacology*; D009153:Mutagens; D010053:Ovary; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D006898:Hydroxylamines; D009153:Mutagens