title: Spontaneous short-term fluctuations in the daily pattern of heart rate, body temperature and locomotor activity in the laboratory rat.
abstract: Heart rate (HR), body temperature (BT) and locomotor activity (LA) were measured continuously over 5 days in freely moving rats. In addition to the well-known circadian rhythms, all variables exhibited considerable fluctuations in amplitude mainly during the dark, but also in the light periods. The values of HR varied from 286 +/- 12 to 470 +/- 26 b.p.m. and BT from 36.15 +/- 0.15 degrees C to 38.45 +/- 0.25 degrees C. The large variability of HR, BT and LA within a single day was due more to large short-term fluctuations within periods of about 3-5 hours duration, than to differences between the light and the dark period. Good consistency of daily patterns and similarity of the 3 variables was found within the animals. Usually there were 3 or 4 regular peaks during the dark and often another peak 3-4 hours after the onset of light. Correlation coefficients, calculated on the basis of 5-min mean values, were highly significant (P less than 0.001) for LA vs HR (0.61-0.73), LA vs BT (0.40-0.53), and HR vs BT (0.61-0.68). Between-hour correlations were higher than these common correlations of 5-min values. HR vs BT (0.76-0.83) and LA vs BT (0.63-0.79) correlated as well as LA vs HR (0.72-0.83). The short-term fluctuations (within-hours) gave lower correlation coefficients for LA vs BT (0.23-0.32) and HR vs BT (0.29-0.41) than LA vs HR (0.40-0.70). This seems to result from a physiological delay of BT relative to HR and LA.
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D001831:Body Temperature; D002940:Circadian Rhythm; D006339:Heart Rate; D008297:Male; D009043:Motor Activity; D051381:Rats; D011919:Rats, Inbred Strains / Q000502:physiology*