Borderline tuberculoid leprosy following BCG vaccination. A case report.
Borderline tuberculoid leprosy was diagnosed clinically and histologically in a four year-old boy about 6 months after intradermal vaccination with BCG. His mother reported that a lesion began to appear above the vaccination site on the arm 2 weeks after the vaccination, and a second lesion appeared on the chin 2 months later. Responses in the lymphocyte transformation test to sonicated Mycobacterium leprae, BCG, and to PPD were consistent with a tuberculoid leprosy infection. Precipitation of BT leprosy by intradermal BCG infection may possibly represent the overcoming of a phase of primary suppression in an individual who might otherwise have progressed toward lepromatous leprosy. The implications of this hypothesis for the planning of a controlled trial of an anti-leprosy vaccine are discussed.
D001500:BCG Vaccine / Q000009:adverse effects*; D002675:Child, Preschool; D006801:Humans; D007918:Leprosy / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D008213:Lymphocyte Activation; D008297:Male
D001500:BCG Vaccine