Amphetamine behavioral toxicity: rotational behavior after chronic intrastriatal infusion.
The behavioral "reverse tolerance" to d-amphetamine in rats has not been clearly established for the high-dose, sustained d-amphetamine exposure relevant to human behavioral toxicity, especially the amphetamine psychosis. We have looked for alterations in the d-amphetamine response following pretreatment by a newer pharmacologic intervention, the continuous chronic unilateral infusion of highdose d-amphetamine into the caudate-putamen. We found that the circling response to a subsequent intraperitoneal injections of d-amphetamine is consistently ipsilateral compared to saline controls, suggesting tolerance development. This finding, and that of minimal apomorphine-induced rotation in these animals, is discussed in terms of a functional imbalance of right and left nigrostriatal dopamine activity, possibly due to dopamine depletion.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004292:Dominance, Cerebral / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D011292:Premedication; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects*
D011954:Receptors, Dopamine; D001058:Apomorphine; D003913:Dextroamphetamine