Selective enhancement of radiation response in a C3H mammary carcinoma by cisplatin.
The interaction between cisplatin and radiation was studied in a C3H mammary carcinoma and its surrounding normal skin. Treatment with 6 mg/kg of cisplatin given 30 mins before irradiation enhanced the radiation response in the tumor by a factor of 1.7, whereas the same drug treatment given immediately after or 4 hrs after irradiation only enhanced the effect by a factor of 1.2--1.3. No interaction between radiation and cisplatin was observed in the surrounding skin. It is hypothesized that in the C3H mammary carcinoma the prominent radiation-modifying effect of cisplatin given before radiation is due to a radiosensitization involving hypoxic tumor cells combined with a tumor cell-destructive effect of the drug itself.
D000818:Animals; D002945:Cisplatin / Q000627:therapeutic use*; D004307:Dose-Response Relationship, Radiation; D008325:Mammary Neoplasms, Experimental / Q000532:radiotherapy*; D051379:Mice; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D012867:Skin / Q000528:radiation effects; D014022:Tissue Survival / Q000528:radiation effects
D011838:Radiation-Sensitizing Agents; D002945:Cisplatin