[Inhibition of stress reactions by magnesium. Beneficial effects of parenteral magnesium therapy on the development of stress ulcers in rats (author's transl)].
In rats fasted for 24 h with drinking-water ad libitum, gastric ulcers were produced by immobilization for 18 h. Subcutaneous injections of magnesium-aspartate-hydrochloride (Maganesiocard) induced pronounced hypermagnesemia after about 1, 7 and 13 h. Macroscopical estimation of gastric lesions as well as the quantitative microscopical examination performed under blind conditions and considering both surface and depth of the ulcers revealed significant protective effects of the magnesium therapy.
D000818:Animals; D001224:Aspartic Acid / Q000627:therapeutic use; D005260:Female; D008274:Magnesium / Q000097:blood / Q000627:therapeutic use*; D051381:Rats; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000188:drug therapy*
D001224:Aspartic Acid; D008274:Magnesium
Stress-Abschirmung durch Magnesium. Günstige Wirkungen einer parenteralen Magnesium-Therapie auf die Entstehung von Stress-Ulzera bei Ratten.