[Advantages of using pharmacologic tests to characterize bacterial vaccines].
The possibility of using pharmacological tests to determine side effects produced by adsorbed DPT vaccine and chemical typhoid vaccine was studied. Both vaccines were shown to be capable of prolonging sleep induced by hexenal or thiopental in experimental animals. The following difference in the action of these two preparations was revealed on the model of "chemical convulsions" induced by the injection of thiosemicarbazide: while immunization with DPT vaccine acitivated thiosemicarbazide-induced convulsive syndrome in mice, no such stimulating effect was observed after the injection of typhoid, vaccine. The study of pharmacological effects allowed to evaluate some aspects of the side effects producted by prophylactic preparations.
D000818:Animals; D001428:Bacterial Vaccines / Q000592:standards; D004168:Diphtheria Toxoid / Q000633:toxicity*; D006591:Hexobarbital; D006801:Humans; D051379:Mice; D010567:Pertussis Vaccine / Q000633:toxicity*; D012640:Seizures / Q000209:etiology; D012893:Sleep Wake Disorders / Q000209:etiology; D013745:Tetanus Toxoid / Q000633:toxicity*; D013874:Thiopental; D013882:Thiosemicarbazones; D013997:Time Factors; D014436:Typhoid-Paratyphoid Vaccines / Q000633:toxicity*
D001428:Bacterial Vaccines; D004168:Diphtheria Toxoid; D010567:Pertussis Vaccine; D013745:Tetanus Toxoid; D013882:Thiosemicarbazones; D014436:Typhoid-Paratyphoid Vaccines; D006591:Hexobarbital; D013874:Thiopental
O tselesoobranznosti ispol'zovaniia farmakologicheskikh testov dlia kharakteristiki bakterial'nykh vaktsin.