A case of hemolytic disease of the newborn caused by anti-M: serological study of maternal blood.
These case is described of a woman with repeated stillbirths. Her serum contained high-titered anti-M antibodies. Treatment of the serum with 2-mercaptoethanol resulted in do reduction in anti-M titer. The serum fraction consisting mainly of IgG exhibited a markedly high anti-M titer compared with the IgM fraction. Anti-M antibodies eluted from OM red cells could be removed by precipitation with specific anti-IgG. Thus, the repeated stillbirths are ascribed to IgG and anti-M antibodies were formed during incompatible pregnancy and crossed the placenta.
D000328:Adult; D004899:Erythroblastosis, Fetal / Q000276:immunology*; D005260:Female; D005313:Fetal Death / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000032:analysis*; D008951:MNSs Blood-Group System / Q000276:immunology*; D011247:Pregnancy
D007518:Isoantibodies; D008951:MNSs Blood-Group System