Effect of phenobarbital on the toxicity and antitumor activity of dibromodulcitol and dianhydrogalactitol.
5-Ethyl-5-phenylhexahydropyrimidin-2,4,6-trione (phenobarbital) pretreatment significantly decreased the acute toxicity of 1,6-dibromo-1,6-dideoxygalactitol (dibromodulcitol) in H/Riop-Swiss mice and Wistar rats. Toxicity of dianhydrogalactitol, however, was not influenced to a considerable measure. Phenobarbital did not alter in itself the growth rate of the tumours examined. It significantly reduced, however, the antitumor activity of dibromodulcitol in NK/Ly-mouse lymphoma and Yoshida rat tumor. In contrast, the cytostatic effect of dianhydrogalactitol was not influenced at all by phenobarbital. The dissimilar effects of phenobarbital on the toxicity and anti-tumour activity of dibromodulcitol and dianhydrogalactitol are probably due to differences both in their metabolism and pharmacodynamics.
D000818:Animals; D000970:Antineoplastic Agents; D003961:Dianhydrogalactitol / Q000494:pharmacology* / Q000633:toxicity; D004347:Drug Interactions; D005260:Female; D051379:Mice; D008936:Mitolactol / Q000494:pharmacology* / Q000633:toxicity; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013402:Sugar Alcohols / Q000494:pharmacology*
D000970:Antineoplastic Agents; D013402:Sugar Alcohols; D003961:Dianhydrogalactitol; D008936:Mitolactol; D010634:Phenobarbital