title: [Potassium, magnesium, copper, manganese and cobalt salts of aspartic acid on platelet factor 3 availability (author's transl)].
abstract: Inzolen, a combination of the potassium, magnesium, copper, manganese and cobalt salts of aspartic acid, inhibits the second phase of ADP-induced aggregation probably by affecting the membrane-located adenylatecyclase/phosphodiesterase system. Correspondingly inzolen affects the activation of platelet factor 3 (PF3), which is also located in the platelet membrane. Thus spontaneous as well as kaolin-induced platelet factor availability is reduced by inzolen. The significant inhibition of factor 3 availability can be interpreted by a magnesium-mediated activation of phosphoryltransferases.
mesh_terms: D001224:Aspartic Acid / Q000494:pharmacology*; D001779:Blood Coagulation Factors / Q000032:analysis*; D003035:Cobalt / Q000494:pharmacology; D003300:Copper / Q000494:pharmacology; D006801:Humans; D008274:Magnesium; D008345:Manganese / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D010977:Platelet Factor 3 / Q000032:analysis*; D011188:Potassium
chemical_list: D001779:Blood Coagulation Factors; D001224:Aspartic Acid; D010977:Platelet Factor 3; D003035:Cobalt; D008345:Manganese; D003300:Copper; C025649:Inzolen; D008274:Magnesium; D011188:Potassium
vernacular_title: Untersuchungen zum Einfluss eines Wirkstoffgemisches aus Kalium-, Magnesium-, Kupfer-, Mangan- und Kobaltsalzen der Asparaginsäure auf die Plättchenfaktor-3-Verfügbarkeit.