New anthracycline antibiotics, auramycins and sulfurmycins. II. Isolation and characterization of 10 minor components (C approximately G).
Following the discovery of new anthracycline antibiotics, auramycins A and B and sulfurmycins A and B, we found 10 minor analogues of auramycins and sulfurmycins, C, D, E, F and G, from the culture broth of a mutant strain of Streptomyces galilaeus OBB-111 and prepared 2 analogues as the chemical derivatives from auramycin G and sulfurmycin G. All analogues have a sugar moiety at C-7 position of the aglycones. These analogues exhibit activities against Gram-positive bacteria and P388 leukemia.
D000873:Anthracenes / Q000302:isolation & purification / Q000494:pharmacology; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D009682:Magnetic Resonance Spectroscopy; D009279:Naphthacenes / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000032:analysis*
D000873:Anthracenes; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes; C036706:auramycin D; C036705:auramycin C; C036707:auramycin E; C036709:auramycin G; C036701:sulfurmycin D; C036700:sulfurmycin C; C036702:sulfurmycin E; C036704:sulfurmycin G; C036708:auramycin F; C036703:sulfurmycin F