title: Prolactin-secreting pituitary adenomas: neurosurgical management of 37 patients.
abstract: Transsphenoidal exploration was performed on 37 patients with hyperprolactinemia and a sellar polytomographic picture consistent with an adenoma. Twenty-two patients were found to have a microadenoma, and 14 were found to have macroadenomas. In one patient who had recently received bromocriptine, no tumor was found. Seventy-two percent of patients with microadenomas had complete resolution of all signs and symptoms; only 35% of the patients with macroadenoma were cured. There was no mortality and minimal morbidity. Seventy-five percent of those patients who desired pregnancy delivered normal children. Transsphenoidal resection is a safe and effective therapeutic modality. The present diagnostic tests and therapeutic management of these patients at our institution is the subject of this report.
mesh_terms: D000236:Adenoma / Q000150:complications / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000568:Amenorrhea / Q000150:complications; D005260:Female; D005687:Galactorrhea / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications / Q000601:surgery*; D011247:Pregnancy; D011388:Prolactin / Q000097:blood*; D013960:Thyroid Function Tests
chemical_list: D011388:Prolactin