Effects of AR-L 115 BS on hemodynamics, myocardial oxygen consumption and cardiac pumping efficiency.
The effects of 2-[(2-methoxy-4-methylsulfinyl)phenyl]-1H-imidazo[4,5-b]pyridine (AR-L 115 BS) on hemodynamics, myocardial oxygen consumption and cardiac pumping efficiency were tested on closed-chest dogs in cardiac catheterization technique. Doses in the range of 0.1 up to 4.0 mg/kg b. w. were injected i.v. A therapeutical dose is to be expected in the range of 1.0 mg/kg b. w., showing a distinct positive inotropic effect and reducing endsystolic volume without increase of heart rate and myocardial oxygen consumption.
D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004285:Dogs; D004734:Energy Metabolism / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects
D002316:Cardiotonic Agents; D007093:Imidazoles; C029758:sulmazole