Effect of dihydroxydibutylether (DHBE) on bile flow and composition in rats with ethynylestradiol-induced cholestasis.
Administration of dihydroxydibutylether (DHBE, Dis-Cinil) to rats with ethynylestradiol(EE)-induced cholestasis provoked an increase in bile flow and output of bile acids and phospholipids. Since EE-induced cholestasis is related to the condition observed in humans, a clinical trial of DHBE in cholestatic syndromes seems worthwhile.
D000818:Animals; D001646:Bile / Q000187:drug effects* / Q000378:metabolism; D000440:Butanols / Q000494:pharmacology*; D002779:Cholestasis / Q000139:chemically induced* / Q000378:metabolism; D004987:Ethers / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D051381:Rats
D000440:Butanols; D004987:Ethers; D004997:Ethinyl Estradiol; C000987:4,4'-oxydi-2-butanol