The effect of post-conditioning exposure to morphine on the retention of a morphine-induced conditioned taste aversion.
In the following experiment, multiple injections of morphine sulfate following the acquisition of a morphine-induced taste aversion had no effect on the retention of the previously acquired aversion. Post-conditioning injections of morphine resulted in the development of physical dependence to morphine and led to a decrement in the ability of morphine to induce a subsequent aversion to a second novel taste. This failure of post-conditioning exposures to morphine to affect a previously acquired morphine-induced taste aversion even though tolerance to morphine had occurred was discussed in the context of Rescorla's event-memory model of conditioning.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects; D005260:Female; D006801:Humans; D008568:Memory / Q000187:drug effects*; D009020:Morphine / Q000494:pharmacology*; D009021:Morphine Dependence / Q000523:psychology; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D013649:Taste
D009270:Naloxone; D009020:Morphine