title: Heat-shock proteins in sea urchin embryos. Transcriptional and posttranscriptional regulation.
abstract: The production of heat-shock proteins in sea urchin embryos is accompanied by the appearance at the polysomal level of their relative mRNAs, as shown by their translation in a cell-free system; thus suggesting that the regulation of their production occurs at a transcriptional level. The mechanism for the inhibition of the bulk protein synthesis and for its reversal on the other hand should be looked for at a posttranscriptional level, since both these phenomena occur also in the presence of actinomycin D. The heat-shock proteins produced as early as at the mesenchyme blastula stage persist within the embryo at least till the pluteus stage.
mesh_terms: D000818:Animals; D003609:Dactinomycin / Q000494:pharmacology; D004625:Embryo, Nonmammalian / Q000378:metabolism; D005260:Female; D006360:Heat-Shock Proteins; D006358:Hot Temperature; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics*; D012323:RNA Processing, Post-Transcriptional / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics; D012617:Sea Urchins / Q000378:metabolism*; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D006360:Heat-Shock Proteins; D011506:Proteins; D012333:RNA, Messenger; D003609:Dactinomycin