Increased drug effect induced by surgery.
1 A thyrotoxic patient receiving a constant dose of propranolol and digoxin developed marked bradycardia postoperatively. 2 Compared to preoperative levels there was a considerable rise post-operatively in both plasma propranolol and serum digoxin steady-state concentrations. 3 Surgery by effecting drug disposition and disease processes may significantly alter drug handling in the perioperative period.
D001919:Bradycardia / Q000139:chemically induced; D004077:Digoxin / Q000378:metabolism; D005260:Female; D006801:Humans; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011183:Postoperative Complications; D011433:Propranolol / Q000378:metabolism; D013514:Surgical Procedures, Operative; D013965:Thyroidectomy / Q000009:adverse effects
D004364:Pharmaceutical Preparations; D004077:Digoxin; D011433:Propranolol