[Determinations of immunoglobulin from the blood of the umbilical vein after pathological course of pregnancy and in foetal growth retardation (author's transl)].
Serum-IgM and serum-IgA concentrations of 561 unselected samples of umbilical cord were determined by the radial immunodiffusion method (Mancini's technique). The mean IgM value of all blood samples was 13.8 mg%. In 9.9% of all cases only we found measurable IgA values, the average IgA concentration being 4.5 mg%. Elevated IgM values (greater than 30 mg%) - pointing to an intrauterine infection - were found to be more frequent (12.1%) in foetal of growth retardation than with newborn of normal body weight, where the incidence of increased IgM values was 5.5% of the examined cases only (however, without a statistically significant difference). In preceding infections during pregnancy, elevated IgM values (greater than 30 mg%) were also found more frequently than in cases without infections (11.8% vs. 5.7%, respectively). Basing on these results, we can suspect that intrauterine infection is one of the possible causes of foetal growth retardation, but not one of the main ones.
D000328:Adult; D002547:Cerebral Palsy / Q000276:immunology; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D005317:Fetal Growth Retardation / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D007153:Immunologic Deficiency Syndromes / Q000276:immunology; D007231:Infant, Newborn; D008297:Male; D008831:Microcephaly / Q000276:immunology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D011251:Pregnancy Complications, Infectious / Q000276:immunology
D007070:Immunoglobulin A; D007075:Immunoglobulin M
Immunglobulinbestimmungen aus dem Nabelvenenblut nach pathologischem Schwangerschaftsverlauf und bei fetalen Wachstumsretardierungen.