Reutilization of preformed pyrimidines for the synthesis of DNA in rat liver and kidney.
The specific activities of rat liver and kidney DNA pyrimidines increase in animals which have had [2-14C]-orotic acid administered several days before killing. This phenomenon is caused by the reutilization of the preformed labeled pyrimidine components originating mainly from degraded RNAs of the organism.
D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D011743:Pyrimidines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D011743:Pyrimidines; D004247:DNA