Massive pulmonary embolism occurring with corticosteroid and diuretics therapy in a minimal-change nephrotic patient.
A 32-year-old female with a relapsing minimal-change nephrotic syndrome developed a massive pulmonary embolism during the treatment of prednisolone and diuretics. The use of diuretics in addition to a hypercoagulable state associated with nephrotic syndrome per se and corticosteroid was considered to be a direct causative factor for the event. The careful use of diuretics and a consideration of additional anticoagulant therapy are emphasized.
D000328:Adult; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D005260:Female; D005665:Furosemide / Q000009:adverse effects* / Q000627:therapeutic use; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D009402:Nephrosis, Lipoid / Q000188:drug therapy*; D011239:Prednisolone / Q000009:adverse effects* / Q000627:therapeutic use; D011655:Pulmonary Embolism / Q000139:chemically induced*; D013148:Spironolactone / Q000009:adverse effects* / Q000627:therapeutic use
D013148:Spironolactone; D005665:Furosemide; D006493:Heparin; D011239:Prednisolone