Summating potential in Meniere's disease.
This study assesses several electrocochleographic (ECoG) duration and amplitude measures in a clinically defined Meniere's group and compares the results with those from a normal hearing control group and a hearing loss group (cochlear). The summating potential (SP)/action potential (AP) amplitude ratio was the most efficient diagnostic measure, with 62% of the Meniere's group demonstrating abnormal ratios compared to 4% of the normal control group and 17% of the cochlear group. The SP changes were then studied from three angles: 1. Comparison of SP changes with glycerol test results; 2. Comparison of ECoG results before and after shunt surgery; and 3. Recording of SP's in guinea pig ears in which hydrops had been created by obliterating the endolymphatic duct.
D000200:Action Potentials; D000818:Animals; D001300:Audiometry, Evoked Response; D005072:Evoked Potentials, Auditory; D005990:Glycerol; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000503:physiopathology; D006801:Humans; D008575:Meniere Disease / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D013997:Time Factors
D005990:Glycerol