title: Effect of sodium chloride and sorbitol infusions on vascular angiotensin reactivity during third trimester pregnancy.
abstract: Normal pregnancy is associated with refractoriness to the pressor effects of i.v. administered angiotensin II (A II). In pre-eclampsia, this refractoriness to A II is lost several weeks prior to the increase of blood pressure. Infusions of 200 ml of 3% saline or of 40% sorbitol over 30 min, or administration of 2,000 ml of normal saline infused over 2 h, respectively, resulted in an increased vascular angiotensin sensitivity. The effective angiotensin pressor dose (APD) decreased significantly after each test substance (decrease of the mean APD 14.5% after 3% saline, 24% after 40% sorbitol and 25% after normal saline). The data confirm the hypothesis that the principal determinant of pressor responsiveness to A II during pregnancy is arteriolar response; this seems to be modulated by alterations in the sodium content of the vessel wall.
mesh_terms: D000293:Adolescent; D000328:Adult; D000802:Angiotensin Amide / Q000494:pharmacology; D001160:Arterioles / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000503:physiopathology; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012965:Sodium Chloride / Q000494:pharmacology*; D013012:Sorbitol / Q000494:pharmacology*
chemical_list: D012965:Sodium Chloride; D013012:Sorbitol; D000802:Angiotensin Amide