Estrogen treatment enhances dopamine receptor sensitivity in the rat striatum.
Estrogen (125 micrograms/rat) was administered, subcutaneously, to male rats six days before measurements were made. Estrogen treatment increased the number of dopamine receptor sites labeled by [3H]spiroperidol in vitro and the intensity of stereotypy induced by dopamine agonists in vivo. These two measures suggest that estrogen administration significantly influences the number of striatal DA receptors and a response to in vivo striatal DA receptor stimulation.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects*; D004967:Estrogens / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008297:Male; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*; D013134:Spiperone / Q000494:pharmacology; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors
D004967:Estrogens; D011954:Receptors, Dopamine; D013134:Spiperone; D000661:Amphetamine; D001058:Apomorphine