Dipetalonema viteae: ultrastructural study on the in vitro interaction between rat macrophages and microfilariae in the presence of IgE antibody.
The in vitro interaction between rat peritoneal macrophages and Dipetalonema viteae microfilariae in the presence of amicrofilaraemic rat immune serum was studied by transmission electron microscopy. The probable sequence of events leading to the killing of D. viteae microfilaria by macrophages is as follows. (a) Rat peritoneal macrophages in the presence of amicrofilaraemic rat immune serum adhere to the parasite surface, (b) the macrophages extend their pseudopodia around the parasite, (c) the 'lysosome-like' granules discharge their contents on to the parasite surface, (d) the lytic activity of these products begins at the parasite surface and (e) subsequent breaking of the microfilarial cuticle occurs, exposing the parasite intracellular material.
D000818:Animals; D004153:Dipetalonema / Q000276:immunology* / Q000648:ultrastructure; D007073:Immunoglobulin E; D008264:Macrophages / Q000276:immunology* / Q000469:parasitology / Q000648:ultrastructure; D008297:Male; D008842:Microfilariae / Q000276:immunology; D009940:Organoids / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains
D007073:Immunoglobulin E