Isozymes of ribonuclease in human serum and urine. II. A survey of patients with cystic fibrosis.
A comparison of serum and urine RNase isozymes from CF patients, heterozygotes, and control subjects demonstrated that the major RNase isozymes are not abnormal in CF. Some preliminary evidence indicated that RNase activity of the pancreatic extracts administered to CF patients may appear in the urine and result in a slightly different urine isozyme pattern. In addition, the mean serum RNase activities of the CF patients and heterozygotes were significantly greater than the mean activity of the controls, but there was much overlap in values between the groups.
D000818:Animals; D003550:Cystic Fibrosis / Q000201:enzymology*; D006801:Humans; D007527:Isoenzymes / Q000032:analysis; D010179:Pancreas / Q000502:physiology; D012260:Ribonucleases / Q000032:analysis* / Q000097:blood / Q000652:urine; D013552:Swine; D014020:Tissue Extracts / Q000032:analysis
D007527:Isoenzymes; D014020:Tissue Extracts; D012260:Ribonucleases