title: Linkage studies between the halothane (Hal), phosphohexose isomerase (Phi) and the S(A-O) and H red blood cell loci of Pietrain/Hampshire and Landrace pigs.
abstract: Frequency of blood group factors at the A-O and H loci were markedly altered within halothane positive (HP) and halothane negative (HN) composite synthetic Pietrain/Hampshire lines (PTH) over four generations of selection. Linkage studies on the litters from 45 double backcross and 20 mixed and intercross matings, involving the S(A-O), H, Phi and Hal loci, were made in the PTH line and halothane positive and negative selected British Landrace lines. Crossing-over frequencies of 0.05 +/- 0.04, 0.05 +/- 0.03 and 0.1 +/- 0.03 were established between Phi and Hal, H and Hal, and Phi and H respectively. An unequal crossing-over frequency between Phi and H was found when the alleles Ha and Hcd were compared. The difference in recombination frequency between the Ha and Hcd alleles amounted to 0.04 to 0.06. No cross-overs were observed between the S(A-O) and Phi, H or Hal loci in 15 families studied. The position of the S locus in relation to the other loci could not be established, but statistical evidence of association favours a haplotype sequence of Phi-Hal-S-H.
mesh_terms: D000818:Animals; D001789:Blood Group Antigens / Q000235:genetics*; D003433:Crosses, Genetic; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D005838:Genotype; D005956:Glucose-6-Phosphate Isomerase / Q000097:blood / Q000235:genetics*; D006221:Halothane / Q000494:pharmacology*; D008297:Male; D013045:Species Specificity; D013552:Swine / Q000235:genetics*
chemical_list: D001789:Blood Group Antigens; D005956:Glucose-6-Phosphate Isomerase; D006221:Halothane