Single-point prediction methods: a critical review.
This article presents a critical review of a proposed method of dose prediction. Previously published experiences with this method are reviewed. New applications with drugs that have short elimination half-lives and drugs that demonstrate nonlinearity of clearance are discussed. Potential sources of error are demonstrated, using computer simulations.
D002701:Chloramphenicol / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D010672:Phenytoin / Q000378:metabolism; D013806:Theophylline / Q000378:metabolism
D004364:Pharmaceutical Preparations; D010672:Phenytoin; D002701:Chloramphenicol; D013806:Theophylline