title: [Changes in alcohol choice by chronically alcoholized cats as affected by tryptopham, its metabolites and preparations affecting its metabolism].
abstract: In cats unrestrictedly selecting alcohol and water during 5 months - 4.5 years under normal feeding, intraperitoneal injection of 1-tryptophan (5.5 and 65 mg/kg) lowered alcohol intake. Depending on the effect on water intake, a decrease (after a lower dose) or an increase (after a higher dose) in alcohol preference was observed. Tryptophan metabolites (mg/kg): dl-5-hydroxytryptophan (5-HTP, 6 and 12), tryptamine (2.5 and 5), 1-4 and dl-(2 and 6)kynurenine, as well as drugs modifying tryptophan metabolism, such as Ro-4-4602(2), an inhibitor of peripheral decarboxylase of aromatic amino acids, and allopurinol (2), an inhibitor of tryptophan pyrrolase (10 and 17), enhanced alcohol intake. Preference of alcohol was increased after tryptamine and 1-kynurenine and decreased after 5-HTP administration. Control injections of saline and distilled water resulted in a significant increase in alcohol and water intake. Saline increased preference of alcohol.
mesh_terms: D000042:Absorption; D000428:Alcohol Drinking; D000437:Alcoholism / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007737:Kynurenine / Q000627:therapeutic use*; D008297:Male; D014364:Tryptophan / Q000378:metabolism / Q000627:therapeutic use*; D014867:Water / Q000378:metabolism
chemical_list: D014867:Water; D007737:Kynurenine; D014364:Tryptophan
vernacular_title: Izmeneniia vybora alkogolia khronicheski alkogolizirovannymi koshkami pod vliianiem triptofana, ego metabolitov i preparatov, vliiaiushchikh na ego obmen.