In vitro reduction of human blood kininogen by catecholamines.
Plasma kininogen levels were significantly reduced in normal human blood, but not in cell-free human plasma, following 10 min in vitro exposure to, in order of decreasing effectiveness, 6 microM adrenaline, noradrenaline or isopropyl-noradrenaline. Phenoxybenzamine (0.1 mM), an alpha-receptor blocking drug, and 0.5 mM aspirin, an inhibitor of prostaglandin (PG) synthesis, inhibited the action of adrenaline, whereas 0.1 mM propranolol, a beta-receptor blocker, and 0.5 mM indomethacin, another inhibitor of the formation of PG, failed to do so. The results suggest that catecholamines are able to activate cell-mediated activation of the kallikrein system in human blood and that this process can be inhibited by aspirin.
D000293:Adolescent; D000328:Adult; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D002395:Catecholamines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D007704:Kininogens / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology
D002395:Catecholamines; D007704:Kininogens; D010643:Phenoxybenzamine; D011433:Propranolol; D001241:Aspirin; D007213:Indomethacin