A bovine muscle extract with anti-cirrhotic and anti-inflammatory properties in the rat.
An extract from bovine muscle, prepared by proteolytic digestion, inhibits the development of CC1(4)-induced liver cirrhosis when administered either subcutaneously or orally to the rat. It has a significant effect on survival time, liver and body weight, and gross and microscopic features, collagen, water, protein and triglyceride content of liver. It also accelerates the regression of CC1(4)-induced cirrhosis. Most of these effects were also achieved with a heat-stable or lipid fraction of the extract. The heat-stable fraction also shows anti-inflammatory activity in carrageenan- and egg white-induced edemas and in cotton pellet granuloma.
D000818:Animals; D000893:Anti-Inflammatory Agents; D002251:Carbon Tetrachloride; D002417:Cattle; D003094:Collagen / Q000378:metabolism; D005260:Female; D007249:Inflammation / Q000188:drug therapy; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009132:Muscles / Q000502:physiology*; D051381:Rats; D014280:Triglycerides / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D014280:Triglycerides; D003094:Collagen; D002251:Carbon Tetrachloride