title: [Bromopride: pharmacokinetics in dogs (author's transl)].
abstract: The pharmacokinetics of bromopride were studied in dogs following a single oral or i.v. administration. The calculation of the pharmacokinetic parameters was based on an open two-compartment model after i.v. injection and on an open one-compartment model when the drug was given by mouth. Serum elimination half-life following i.v. injection was shown to exceed that after oral ingestion. Bromopride was rapidly transformed into the monodeethyl metabolite accounting for the largest fraction at 4 h after administration.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004285:Dogs; D007275:Injections, Intravenous; D007700:Kinetics; D008787:Metoclopramide / Q000031:analogs & derivatives* / Q000378:metabolism; D013997:Time Factors
chemical_list: C013855:bromopride; D008787:Metoclopramide
vernacular_title: Bromoprid: Pharmakokinetik beim Hund.