Cholesterol esterification of mechanically-induced aortic lesions in normolipemic pigs.
Intimal thickenings were produced in the abdominal aortae of normolipemic pigs by longitudinal mechanical injury. In two-week lesions there was increased I-14C-oleic acid incorporation into esterified cholesterol (CE), accompanied by lipid droplet formation. In twelve-week lesions, lipid droplets had largely disappeared, and the incorporation of 1-14C-oleic acid into CE was similar to that of normal aorta. Increased esterification of cholesterol with oleic acid may be a protective mechanism during the early phases of the arterial repair reaction. Regression of the lesions may be associated with the return of cholesterol esterification activity to normal.
D000818:Animals; D001012:Aorta, Abdominal / Q000293:injuries / Q000473:pathology*; D002788:Cholesterol Esters / Q000378:metabolism*; D008055:Lipids / Q000097:blood*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D009829:Oleic Acids / Q000378:metabolism; D013552:Swine; D013997:Time Factors
D002788:Cholesterol Esters; D008055:Lipids; D009829:Oleic Acids