Concentration profile for the dissolution of drug tablets undergoing simultaneous degradation.
An empirical approach to the concentration-time history of a dissolving drug has resulted in a cube-root equation in which the characteristic constant of the equation embodies the important physical variables of the system. This expression has been used to study the dissolution of a drug that degrades simultaneously in the test solution. An alternative representation of the dissolution process is first-order kinetics. These two approaches are compared by fitting the experimental data of the dissolution of digoxin and melphalan tablets in various media, and a new method for the proper analysis of data for the dissolution of tablets that simultaneously degrade in the test solution is presented.
D002626:Chemistry, Pharmaceutical; D004077:Digoxin; D007700:Kinetics; D008558:Melphalan; D008956:Models, Chemical; D012995:Solubility; D013607:Tablets; D013997:Time Factors
D013607:Tablets; D004077:Digoxin; D008558:Melphalan