Molecular requirements of the active sites of the cholinergic receptors. XVI - Synthesis and cholinergic activity of 2- or 5-alkyl or 5-phenyl-4-methyl-3-oxo-1-dimethylaminomethylcyclopentane methiodide.
In order to study the cholinergic receptor through affinity chromatography, some derivatives of deoxamuscarone (I a) incorporating alkyl and phenyl substituents at the positions 2 and 5 were synthesized as model compounds. However, the sharp drop in activity and the lack of discrimination between nicotinic and muscarinic receptors exhibited by the compounds discourage their further development as affinity reagents.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009116:Muscarine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D010277:Parasympathomimetics / Q000138:chemical synthesis*; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects
D010277:Parasympathomimetics; D011950:Receptors, Cholinergic; D009116:Muscarine