[Differentiation of components of the filtration barrier of the human kidney during the prenatal period of development].
Peculiarities in formation of the nephric filtrative barrier have been studied in 5-6, 7-8, 9-10, 11-12, 15-16, 17-18, 20-24, 28-36-week-old human embryos. As the data of the light optic and electron microscopic analysis have demonstrated, on th 6th-7th weeks of the embryonic development the capsule of the nephric body is represented as a well developed parietal folium, consisting of one layer of flattened cells, and nondifferentiated epithelial cells of the visceral folium. The latter have giant nuclei and a narrow cytoplasmic rim. Among them, islets of immature endothelial cells with electron transparent cytoplasm and large nuclei occur. The thickness of the peripheral part of cytoplasm in endotheliocytes is nearly the same as that of pericaryon; fenestrae and pores are absent. The basal membrane is twisted, and in some places is interrupted. On the 20th-32nd weeks the components of the nephric filtrative barrier are differentiated. Formation of cytotrabeculae and cytopodia is intensified. In the endothelial cells of the glomerular capillaries the pericaryon is distinctly separated from the flattened cytoplasmic part, in which fenestrae and pores begin to appear.
D002454:Cell Differentiation; D004727:Endothelium / Q000648:ultrastructure; D005865:Gestational Age; D006801:Humans; D007678:Kidney Glomerulus / Q000098:blood supply / Q000196:embryology* / Q000648:ultrastructure; D008854:Microscopy, Electron
Differentsiatsiia komponentov filtratsionnogo bar'era pochki cheloveka v prenatal'nom periode razvitiia.