Volunteer studies of typhoid fever and vaccines.
A series of studies evaluated the efficacy of three categories of typhoid vaccines: killed organisms given parenterally and orally and living attenuated mutants given orally. Vaccinees and unvaccinated controls were challenged with a single strain of virulent Salmonella typhi. Control individuals with prior military service (i.e. mandatory parenteral immunization) were significantly protected compared to non-veterans. Clinical protection of vaccinees was greatest (87%) following oral immunization with a mutant strain lacking epimerase.
D000284:Administration, Oral; D006801:Humans; D007267:Injections; D008297:Male; D014435:Typhoid Fever / Q000517:prevention & control*; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage; D014611:Vaccination / Q000379:methods*; D014613:Vaccines, Attenuated / Q000008:administration & dosage; D014728:Veterans
D014436:Typhoid-Paratyphoid Vaccines; D014613:Vaccines, Attenuated