title: Effects of extracts of denervated muscles on the morphology of cultured muscle cells.
abstract: Previously, trophic effects of extracts from whole chick embryos and from innervated muscles on cultured muscle cells were described. The present study demonstrated similar effects of extracts from 10-days denervated chick muscles. Extracts from innervated as well as from denervated muscles exsanguinated in vivo with saline prior to dissection showed only marginal trophic activity, suggesting a major contribution of serum components to the trophic effects of tissue extracts. Indeed, serum of adult chicks appeared to have a trophic action similar to that of chick embryo extract.
mesh_terms: D000818:Animals; D001769:Blood; D002478:Cells, Cultured; D002642:Chick Embryo; D002645:Chickens; D009121:Muscle Denervation; D009132:Muscles / Q000166:cytology*