[Action of a polyene macrolide on hyperdyslipidemic disorders].
The efficacy and the tolerance of a polyene macrolide, mepartricin (SPA-S-160), able to interfere with intestinal absorption of cholesterol, were evaluated on 50 patients with primary hyperlipemia. Administration of 3 tablets/die for 30 days caused a significant decrease (P less than 0.01) in the lipid values, which, further controlled 30 days following treatment, proved to have remained lower than those observed at the beginning of the study.
D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000378:metabolism; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D008613:Mepartricin / Q000627:therapeutic use*; D008875:Middle Aged; D011090:Polyenes / Q000627:therapeutic use*
D011090:Polyenes; D008613:Mepartricin; D002784:Cholesterol
Influenza di un macrolide polienico sulle turbe iperdislipidemiche.