[Cell division reaction in mouse Ehrlich ascites tumor in response to adrenaline].
Adrenaline exerts the mitosis-inhibitory effect at a single intraperitoneal administration to mice with Ehrlich's ascites carcinoma. The dose of 1 microgram/g bw produces an effect that lasts over one hour with subsequent normalization of the mitotic index. The doses of 1.5 and 2 microgram provide an effect that lasts during the whole experiment. The changes in the mitotic activity indicate that the tumor reacts to adrenaline by mitosis inhibition and thus retains adrenoreception inherent in normal tissues. The difference in the degree and duration of inhibition after injection of various doses of adrenaline are consequent on their action on specific phases of mitosis.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008938:Mitosis / Q000187:drug effects*; D009368:Neoplasm Transplantation
D004837:Epinephrine
Reaktsiia kletochnogo deleniia v astsitnoĭ opukholi Erlikha mysheĭ na deĭstvie adrenalina.