Regulation of collagen dissolution in the human cervix by oestradiol-17 beta and progesterone.
Explants of non-pregnant human cervix in culture for 10 days spontaneously synthesized collagenolytic enzymes with dissolved the collagen in the tissue, resulting in the release of hydroxyproline-containing peptides. Progesterone at 8 X 10(-7) M and oestradiol-17 beta at 4 X 10(-6) M reduced this breakdown by 50%, but oestradiol-17 beta was only inhibitory if the tissue was maintained in an oestrogen-containing environment throughout the preparation of the tissue explants. We conclude that the connective tissue matrix of the human cervix is partly under hormonal control.
D002584:Cervix Uteri / Q000187:drug effects* / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D046508:Culture Techniques; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D010455:Peptides / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology*
D010455:Peptides; D011374:Progesterone; D004958:Estradiol; D003094:Collagen