Meiosis-inducing and meiosis-preventing substances in human male reproductive organs.
The initiation of meiosis is controlled by two substances, a meiosis-inducing substance (MIS) and a meiosis-preventing substance (MPS). These have been shown to be present in reproductive organs of both sexes of different mammals. In this investigation MIS and MPS were also shown to be present in man. MIS was found in fetal and adult epididymides and testes. MPS was obtained from the tests of one fetus, which was delivered by laparotomy. MPS could not be found in the testes of another fetus, which was aborted by prostaglandin F2 alpha and oxytocin. No or only weak MPS activity was detectable in the adult testis. This report indicates that continued spermatogenesis might be influenced by the MIS:MPS ratio. MPS was shown not to be species-specific. MIS and MPS activity have been evaluated by qualitative scoring of the different germ cell stages present in fetal gonads after culture in used media containing MIS or MPS.
D000328:Adult; D000818:Animals; D003470:Culture Media; D004822:Epididymis / Q000166:cytology*; D005260:Female; D005333:Fetus / Q000166:cytology; D005854:Germ Cells / Q000166:cytology; D006801:Humans; D008297:Male; D008540:Meiosis; D051379:Mice; D013737:Testis / Q000166:cytology*
D003470:Culture Media