Antiviral effect of haloperidol on Rauscher murine leukemia virus.
The neuroleptic drug haloperidol (Hal) shows, when administered in multiple intraperitoneal or intravenous injections beginning at 5 hrs post inoculation of Rauscher leukemia virus to male NMRI mice, a marked activity in inhibiting virus-induced splenomegaly and prolonging mean survival time. Evidence is presented that a direct action of the drug on the virus is involved in its inhibitory effect.
D000818:Animals; D006220:Haloperidol / Q000627:therapeutic use*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011925:Rauscher Virus / Q000187:drug effects
D006220:Haloperidol