Peristalsis abolishes the release of methionine-enkephalin from guinea-pig ileum in vitro.
The release of methionine-enkephalin from superfused guinea-pig ileum has been demonstrated. Methionine-enkephalin, as measured by radioimmunoassay, was shown to be released from tissues maintained at an intraluminal pressure of O cm water (resting conditions). Increased intraluminal pressure (5 cm water) induced peristalsis and abolished the release of methionine-enkephalin. These results provide further evidence that endogenous opioids may be involved in the modulation of contractile activity in the guinea-pig ileum.
D000818:Animals; D004723:Endorphins / Q000378:metabolism*; D004744:Enkephalin, Methionine; D004745:Enkephalins / Q000378:metabolism*; D005769:Gastrointestinal Motility / Q000187:drug effects; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D010528:Peristalsis / Q000187:drug effects
D004723:Endorphins; D004745:Enkephalins; D009270:Naloxone; D004744:Enkephalin, Methionine