title: Iosulamide: human tolerance study of a new intravenous cholangiographic drug.
abstract: A simple dose-ranging human tolerance study of an experimental intravenous cholangiographic agent (iosulamide) was performed. Doses from 10-40 ml were infused in normal, healthy male volunteers. Bile duct opacification appeared adequate at 30-40 ml doses. With higher doses, a large percentage of the drug was excreted in the urine. Forty percent of the subjects manifested symptoms of minimal or mild contrast reactions.
mesh_terms: D000328:Adult; D001663:Bilirubin / Q000097:blood; D002758:Cholangiography / Q000379:methods*; D002765:Cholecystography / Q000379:methods; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000652:urine; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D006439:Hemodynamics; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged
chemical_list: D003973:Diatrizoate; C028779:iosulamide meglumine; D003974:Diatrizoate Meglumine; D001663:Bilirubin