Osteonecrosis of the femoral head in a family with hyperlipoproteinemia.
A family of four generations has been identified as having hyperlipoproteinemia as well as radiologic evidence of active or healed osteonecrosis of the femoral head. Sixteen family members were available for complete clinical, radiologic, and laboratory examination. Six living and two deceased members were found to have both conditions. Hyperlipoproteinemia should be considered in the differential diagnosis of the idiopathic osteonecrosis of the femoral head; some common pathogenetic factor may underlie these two conditions when they coexist in a familial pattern.
D000293:Adolescent; D000328:Adult; D002784:Cholesterol / Q000097:blood; D005260:Female; D005271:Femur Head Necrosis / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D006951:Hyperlipoproteinemias / Q000150:complications / Q000235:genetics*; D008074:Lipoproteins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010384:Pelvic Bones / Q000000981:diagnostic imaging; D011859:Radiography; D014280:Triglycerides / Q000097:blood
D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol