[Quantitative characterstics of the immune response and natural resistance factors in inbred and noninbred rats].
Thymic and splenic cell populations, natural resistance factors and the time course of the primary immune response in August and Wistar rats was studied. The animals were found to have no differences in the number of immunoglobulin-positive and Fc-rosette-forming cells, as well as in their capacity for blast transformation under the influence of phyto-hemagglutinin, concanavalin A and lipopolysaccharide. August rats were found to have the higher (by 56%) content of complement in the blood than Wistar rats, while no essential difference in the content of lysozyme and beta-lysins was detected. The immunization of the animals with sheep red blood cells was accompanied by the similar character of the time course of antibody forming cells reaching their maximum level on the 8th day after immunization; immune response in Wistar rats was even more pronounced.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D000937:Antigen-Antibody Reactions; D005260:Female; D007113:Immunity, Innate; D007114:Immunization; D007700:Kinetics; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051381:Rats / Q000276:immunology*; D011919:Rats, Inbred Strains / Q000276:immunology*; D012397:Rosette Formation; D013154:Spleen / Q000276:immunology
Kolichestvennaia kharakteristika immunogo otveta i faktorov estestvennoĭ rezistentnosti u inbrednykh i neinbrednykh krys.