Acetaldehyde concentration in rat blood and brain during the calcium carbimide--ethanol interaction.
Ethanol was administered to rats by oral intubation 3 h after intraperitoneal administration of calcium carbimide. Increased blood acetaldehyde concentration and the presence of acetaldehyde in brain were found for the calcium carbimide--ethanol interaction. There was no detectable brain acetaldehyde for ethanol administration following saline treatment. The magnitude of the acetaldehyde concentration in blood and brain during the calcium carbimide--ethanol interaction was directly dependent on the doses of calcium carbimide (0.7, 3.5, 7.0 mg/kg) and ethanol (0.5, 1.0, 1.5 g/kg). There was an exponential relationship between brain acetaldehyde concentration and blood acetaldehyde concentration. The threshold blood acetaldehyde concentration, above which acetaldehyde was found in brain, was approximately 6 micrograms/mL.
D000079:Acetaldehyde / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003484:Cyanamide / Q000494:pharmacology*; D003486:Cyanides / Q000494:pharmacology*; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013997:Time Factors
D003486:Cyanides; D000431:Ethanol; D003484:Cyanamide; D000079:Acetaldehyde