Acrylonitrile-14C metabolism in rats: effect of the route of administration on the elimination of thiocyanate and other radioactive metabolites in urine and feces.
In Wistar rats, the elimination of the sum of radioactive metabolites of acrylonitrile--14C was not markedly influenced by the rote of acrylonitrile administration. The elimination of thiocyanate, however, was significantly higher after oral (23% of the dose) than after intraperitoneal (4%), subcutaneous (4.6%), or intravenous (1.2%) administration. The elimination of the sum of radioactive metabolites was highest in the first 4 hours after acrylonitrile administration and rapidly decreased, whereas the excretion of thiocyanate reached maximum between hour 8 and 14 after oral or intraperitoneal administration. Less than 1% of radioactivity of the acrylonitrile--14C dose was eliminated in feces irrespective of the route of administration.
D000181:Acrylonitrile / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D000284:Administration, Oral; D000818:Animals; D007271:Injections, Intradermal; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D009570:Nitriles / Q000378:metabolism*; D051381:Rats; D013861:Thiocyanates / Q000378:metabolism* / Q000652:urine
D009570:Nitriles; D013861:Thiocyanates; D000181:Acrylonitrile