[Effect of mixed function oxidases on phthalophos transformation in rat liver].
Phthalophos, organophosphoric pesticide, in the perfused isolated liver of rats transforms to water-soluble oxymethyl phthalimide and phthalimide. The induction of the liver hydroxylating enzymic system with milbex accelerates transformation of phthalophos: in 5 min only 14% of its initial amount is found in perfusate, while in the control--52%. The inhibition of the hydroxylating enzymic system with tetramethylthiuramdisulphide (dithiocarbamate pesticide) inhibits transformation of phthalophos: in 15 min perfusate contains 33% of its initial amount and the control--16%. Induction and inhibition of the hydroxylating enzymic system of the liver affect essentially the phthalophos toxicodynamics, decreasing the degree of the cholinesterase activity.
D000818:Animals; D001391:Azo Compounds / Q000494:pharmacology; D001559:Benzhydryl Compounds / Q000494:pharmacology; D001711:Biotransformation; D004790:Enzyme Induction; D005260:Female; D007306:Insecticides / Q000378:metabolism* / Q000494:pharmacology; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D010088:Oxidoreductases / Q000096:biosynthesis / Q000378:metabolism*; D010706:Phosmet / Q000378:metabolism*; D051381:Rats; D013893:Thiram / Q000494:pharmacology
D001391:Azo Compounds; D001559:Benzhydryl Compounds; D007306:Insecticides; D013893:Thiram; C008529:milbex; D010088:Oxidoreductases; D010706:Phosmet
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