title: [Excretion of lead in the gastric and duodenal juice of persons with occupational lead poisoning and normal subjects].
abstract: Lead was measured in the gastric and duodenal juice of three patients with lead poisoning (blood concentrations of lead: 4.30; 5.16; 5.50 mumol/l). The lead excretion into the gastric juice was 94.6; 29.9 and 18.3 nmol Pb X h-1 for the poisoned persons and 57.9 +/- 38.1 nmol Pb X h-1 for healthy persons (n = 20). Pentagastrin (6 microgram/kg, i.m.) stimulated lead excretion in both groups (normal + 109%, lead poisoned persons: + 180%; + 187%; + 311%). The lead excretion was correlated with an increase of HCl-secretion and volume in healthy persons. The lead excretion into the duodenal juice after secretion (1 unit/kg) amounted to 14.2 +/- 8.8 nmol Ph X h-1 in healthy persons, whereas after secretion plus caerulein 18.8 +/- 7.2 nmol Pb X h-1 were found. In the duodenal juice of the lead poisoned persons 27.5 and 474.9 nmol Ph X h-1 respec. were found after secretion and 58.9 and 491.8 nmol Pb X h-1 respec. after secretion plus caerulein. Lead excretion was correlated with enzyme secretion (trypsin and chymotrypsin).
mesh_terms: D002108:Ceruletide / Q000494:pharmacology; D004386:Duodenum / Q000378:metabolism*; D005750:Gastric Juice / Q000032:analysis* / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D006851:Hydrochloric Acid / Q000378:metabolism; D007854:Lead / Q000032:analysis* / Q000378:metabolism; D007855:Lead Poisoning / Q000097:blood / Q000378:metabolism*; D010418:Pentagastrin / Q000494:pharmacology; D012633:Secretin / Q000494:pharmacology
chemical_list: D012633:Secretin; D007854:Lead; D002108:Ceruletide; D010418:Pentagastrin; D006851:Hydrochloric Acid
vernacular_title: Uber die Bleiausscheidung im Magen- und Duodenalsaft bei Personen mit gewerblicher Bleivergiftung und Normalpersonen.