No measles virus genetic information detected in multiple sclerosis--derived brains.
Measles virus nucleotide sequences were searched for in diseased and normal-appearing white matter from brains of four multiple sclerosis victims. At the level of sensitivity established, 2.5 to 7.8 measles virus genome-equivalents of RNA, or 4.9 genome-equivalents of putative DNA per diploid cell quantity of DNA, could have been detected. At these levels, no measles virus genetic information was found in any of the four brains.
D000328:Adult; D000368:Aged; D001923:Brain Chemistry; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008459:Measles virus / Q000235:genetics*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral / Q000032:analysis*
D004279:DNA, Viral; D012367:RNA, Viral