[Acute and chronic effects of pyrogen on mitochondrial monoamine oxidase (MAO) activity and respiratory activity in the rabbit liver (author's transl)].
Pyrogen acted on mitochondrial outer membrane or structure to increase the penetration of substrate to mitochondrial MAO. Mitochondrial respiratory activity did not change significantly after acute administration of pyrogen. With chronic administration of pyrogen, the ADP/O ratio of liver mitochondria was increased. These results suggest that the acute administration of pyrogen affects the mitochondrial outer membrane, while the chronic administration affects both the outer and inner membranes.
D000818:Animals; D003579:Cytochrome Reductases / Q000378:metabolism*; D005334:Fever / Q000139:chemically induced; D007425:Intracellular Membranes / Q000201:enzymology; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology*; D008995:Monoamine Oxidase / Q000378:metabolism*; D009245:NADH Dehydrogenase / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects; D011749:Pyrogens / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D013385:Succinate Dehydrogenase / Q000378:metabolism*
D011749:Pyrogens; D013385:Succinate Dehydrogenase; D008995:Monoamine Oxidase; D003579:Cytochrome Reductases; D009245:NADH Dehydrogenase