Effect of histamine in sinus node arrested with reserpine.
Histamine restored spontaneous activity in the isolated rabbit sinus node arrested with reserpine. This fact suggests that catecholamines are not the unique activators of adenylate cyclase required for cardiac pacemaking, and may be replaced by histamine.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology*; D011817:Rabbits; D012110:Reserpine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012849:Sinoatrial Node / Q000187:drug effects*
D002395:Catecholamines; D006632:Histamine; D012110:Reserpine; D000262:Adenylyl Cyclases