Polydactyly Nagoya, Pdn: A new mutant gene in the mouse.
A new hereditary polydactyly (gene symbol Pdn) was found in the course of breeding JCL : ICR mice. The genetic analysis indicated that the polydactyly was an autosomal dominant trait. The homozygotes died within two days after birth. The homozygous fetuses or newborn had 1-3 extra-digits both in te fore- and hindlimbs on the preaxial side. They occasionally showed exencephaly, cleft palate, open eyelid, short tibia and fibula or deformed sternum. The heterozygotes had one extra-digit preaxial side. They occasionally showed exencephaly, heterozygotes had one extra-digit preaxially in the hindlimb and an enlarged first digit on the forelimb which often showed bifurcated distal phalanx. A tab on the postaxial side of the forelimb was found in all homozygotes and in some heterozygotes.
D000818:Animals; D005260:Female; D005552:Forelimb / Q000002:abnormalities; D005799:Genes, Dominant; D006579:Heterozygote; D006614:Hindlimb / Q000002:abnormalities; D006720:Homozygote; D008297:Male; D051379:Mice; D009154:Mutation; D012376:Rodent Diseases / Q000235:genetics*; D014034:Toes / Q000002:abnormalities*