Evaluation of nystatin stability using tristimulus colorimetry.
A tristimulus reflectance spectrophotometer was used to examine the color changes of nystatin during accelerated stability studies, and a relationship was observed between the loss of microbiological potency and the change in color during thermal degradation. By substitution of the measured tristimulus values in the Kubelka-Munk equation, the remission function was calculated and resulted in a linear response with time. Application of the technique to bulk raw materials and formulated products is demonstrated, and uses of the technique are discussed.
D003124:Colorimetry; D004355:Drug Stability; D006358:Hot Temperature; D009761:Nystatin; D013997:Time Factors
D009761:Nystatin