title: A 2 year oral carcinogenicity study with cadmium on rats.
abstract: A longterm 2-year feeding study on cadmium using CdCl2 . 1H2O has been performed on Wistar-rats. The tested Cd2+-dietary levels were 1, 3, 10 and 50 ppm, respectively. Fifty male and 50 female rats were used for each of the levels. Hundred rats of each sex served as controls. No effects occurred on food intake and survival rate at any dietary level. Growth was unchanged up to 10 ppm whereas 50 ppm resulted in lower weight gain in males only. Histopathological evaluation of a large variety of tissues revealed a number of tumours. Cadmium administered orally was not associated with an increased incidence of total numbers of tumours or of any specific type of neoplasia, although the highest level tested resulted in adverse effects.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002104:Cadmium / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D013997:Time Factors
chemical_list: D002104:Cadmium