Prostaglandins /PGs/ and peristalsis.
The effect of some inhibitors of PG-synthesis /Aspirin, Indomethacin and Suprofen/ on the small intestine peristalsis and the PG-like activity in mice was investigated. It was found that the three drugs examined in the applied doses did not affect the small intestine peristalsis but they significantly decreased the PG-like activity. The role of PGs in the physiological peristalsis of the small intestine is discussed.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology; D007421:Intestine, Small / Q000032:analysis* / Q000187:drug effects; D008297:Male; D051379:Mice; D010528:Peristalsis / Q000187:drug effects*; D011453:Prostaglandins / Q000378:metabolism / Q000502:physiology*; D013496:Suprofen / Q000494:pharmacology
D011453:Prostaglandins; D013496:Suprofen; D001241:Aspirin; D007213:Indomethacin