title: A monosialoganglioside is a monoclonal antibody-defined antigen of colon carcinoma.
abstract: The antigen of a monoclonal antibody that is specific for cells of human carcinoma of the colon is a monosialoganglioside as determined by the direct binding of antibody to thin-layer chromatograms of total lipid extracts of tissues. Binding of antibody to chromatograms is detected by autoradiography after the application of iodine-125-labeled F(ab')2 of rabbit immunoglobulin G antibodies to mouse immunoglobulins.
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology*; D000912:Antibodies, Neoplasm / Q000276:immunology*; D000918:Antibody Specificity; D000951:Antigens, Neoplasm / Q000276:immunology* / Q000302:isolation & purification; D002460:Cell Line; D002855:Chromatography, Thin Layer; D003110:Colonic Neoplasms / Q000276:immunology*; D005732:Gangliosides / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D008545:Melanoma / Q000276:immunology; D009439:Neuraminidase / Q000494:pharmacology
chemical_list: D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D005732:Gangliosides; C028885:colon carcinoma monosialoganglioside antigen; D009439:Neuraminidase