title: Experimental evidence of increased ipsilateral gentamicin nephrotoxicity after unilateral ureteral obstruction.
abstract: This study describes an experimental model for the investigation of nephrotoxicity in which the aminoglycoside, gentamicin, is given after unilateral ureteral obstruction is produced. The preliminary findings indicate a significantly more severe loss of renal function in the obstructed kidney which receives gentamicin than in the obstructed kidney which does not.
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis; D000818:Animals; D005839:Gentamicins / Q000009:adverse effects*; D007444:Inulin; D007677:Kidney Function Tests; D008297:Male; D051381:Rats; D014517:Ureteral Obstruction / Q000188:drug therapy*
chemical_list: D005839:Gentamicins; D007444:Inulin