Nimodipine inhibits carbocyclic thromboxane-induced contractions of cerebral arteries.
Carbocyclic thromboxane A2 (CTA2) constricted rabbit basilar and saphenous arteries. The contractions of the basilar artery, but not those of the saphenous artery, were potently inhibited by the calcium antagonist nimodipine. Selective inhibition of thromboxane-induced vasoconstriction of cerebral vessels may contribute to the beneficial actions of calcium antagonists in models of cerebral ischaemia or vasospasm.
D000818:Animals; D001488:Basilar Artery / Q000187:drug effects; D002118:Calcium / Q000037:antagonists & inhibitors*; D002536:Cerebral Arteries / Q000187:drug effects*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009539:Nicotinic Acids / Q000494:pharmacology*; D009553:Nimodipine; D009578:Nitrobenzenes / Q000494:pharmacology; D011817:Rabbits; D013931:Thromboxanes / Q000037:antagonists & inhibitors*; D014662:Vasoconstrictor Agents / Q000037:antagonists & inhibitors*; D014664:Vasodilation / Q000187:drug effects
D009539:Nicotinic Acids; D009578:Nitrobenzenes; D013931:Thromboxanes; D014662:Vasoconstrictor Agents; D009553:Nimodipine; D002118:Calcium