Epileptic discharges produced in monkeys by injection of spleen cells from rabbits immunised with monkey brain.
Cell suspension from the spleen of rabbits immunised with monkey brain gave rise to epileptic discharges in the monkey when injected intracortically, except in the case of one injection from a rabbit not recently given a booster treatment. In contrast, cell suspensions from the spleen of unimmunised rabbits, or of a rabbit immunised with a non-brain material, in all cases failed to be effective. The epileptic discharges began about 2 weeks after injection, were variable in frequency, and lasted throughout the period of recording.
D000818:Animals; D000917:Antibody Formation; D002540:Cerebral Cortex / Q000276:immunology; D005071:Evoked Potentials; D007106:Immune Sera / Q000276:immunology*; D008253:Macaca mulatta; D011817:Rabbits; D012640:Seizures / Q000276:immunology*; D013154:Spleen / Q000276:immunology*
D007106:Immune Sera