Role of Staphylococcus aureus exfoliatin toxin in staphylococcal infections in mice.
Clindamycin at a concentration of 0.18 microgram/ml reduced growth of Staphylococcus aureus in vitro by 40% but inhibited exfoliatin toxin production by 90%. Mice infected with S. aureus and subsequently treated with clindamycin did not exfoliate but still died.
D000818:Animals; D001427:Bacterial Toxins / Q000096:biosynthesis*; D002981:Clindamycin / Q000494:pharmacology / Q000627:therapeutic use*; D005083:Exfoliatins / Q000096:biosynthesis*; D051379:Mice; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000378:metabolism; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism
D001427:Bacterial Toxins; D005083:Exfoliatins; D002981:Clindamycin