[In vivo and in vitro hydroxylation of testosterone and dihydrotestosterone in rats after liver damage and starvation (author's transl)].
The in vivo C-2-hydroxylation of testosterone and 5-dihydrotestosterone in rats was measured by labilisation of tritium as HTO after injection of [1 alpha, 2 alpha-T]testosterone or [1 alpha, 2 alpha-T]5 alpha-dihydrotestosterone (radiospirometry). After experimental liver damage caused by CCl4 or after starvation for 60 h the hydroxylation of the androgens decreased. Similar results were gained by measuring the C-2-hydroxylation of testosterone, 5 alpha-dihydrotestosterone and estradiol.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D013196:Dihydrotestosterone / Q000378:metabolism*; D005260:Female; D006900:Hydroxylation; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D013217:Starvation; D013739:Testosterone / Q000378:metabolism*
D013196:Dihydrotestosterone; D013739:Testosterone
In vivo und in vitro Hydroxylierung von Androgenen in Ratten nach Leberschädigung und Nahrungskarenz.