Sex-related differences in the plasma protein binding of lignocaine and diazepam.
1 The percentage of lignocaine free in the plasma of ten females receiving oral contraceptive medication was significantly greater than in 17 males of similar age (18--42 years). 2 In the same subjects the percentage of diazepam free in plasma was significantly greater in the contraceptive treated group than in 11 contraceptive-free females and significantly greater in contraceptive-free females than in males. 3 The differences in lignocaine binding were almost completely attributable to changes in alpha 1-acid glycoprotein concentration, which is reduced by oestrogens. The binding of diazepam was significantly related to albumin, alpha 1-acid glycoprotein and non-esterified fatty acid concentrations which together were related to 55% of the variation in the binding of this basic compound.
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology; D003975:Diazepam / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000097:blood* / Q000378:metabolism; D008297:Male; D009961:Orosomucoid / Q000097:blood; D011485:Protein Binding; D012709:Serum Albumin / Q000032:analysis; D012737:Sex Factors
D001798:Blood Proteins; D003277:Contraceptives, Oral, Combined; D009961:Orosomucoid; D012709:Serum Albumin; D008012:Lidocaine; D003975:Diazepam