Ultrastructural localization and protective activity of a high-molecular-weight antigen isolated from Legionella pneumophila.
Immunoperoxidase labeling showed that the F-1 antigen of Legionella pneumophila is located on the bacterial cell surface. Protection against lethal intraperitoneal challenge with serogroup 1 L. pneumophila was induced in guinea pigs by heat-killed cells and F-1 antigen from serogroup 1, but not by heat-killed cells or F-1 antigens from serogroup 2, 3, or 4.
D000818:Animals; D000942:Antigens, Bacterial / Q000032:analysis*; D006168:Guinea Pigs; D007114:Immunization; D007875:Legionella / Q000276:immunology* / Q000648:ultrastructure; D007877:Legionnaires' Disease / Q000276:immunology; D008854:Microscopy, Electron; D008970:Molecular Weight
D000942:Antigens, Bacterial