[Hepatotoxicity of cyclophosphamide in the rat after prolonged treatment: a histomorphological study].
The AA. have examined the toxic effects in rats liver caused by cyclophosphamide (12 mg/kg) chronic administration for 12 months. The toxicity for the liver is moderate and the lesions are not specific. The lesion are various histologic changes, lymphomonocytic infiltration of the peri-portal space, periportal fibrosis and interstitial haemorrhages. Similar lesions with lesser recurrence are also in not treated rats.
D000818:Animals; D003520:Cyclophosphamide / Q000633:toxicity*; D005260:Female; D006470:Hemorrhage / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051381:Rats
D003520:Cyclophosphamide
Epatossicita' della ciclofosfamide dopo trattamento protratto nei ratti: studio istomorfologico.