Thyroid hormones and cathepsin D activity in the rat liver, kidney and brain.
The effect of thyroidectomy and subsequent treatment with tri-iodothyronine (T3), as well as that of thyrotoxicosis, was examined on cathepsin D activity in the rat liver, kidney and brain. Thyrotoxicosis resulted in a generalized increase in the enzyme activity in the 3 tissues; the effect of other thyroidal states was diverse and tissue-specific.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002402:Cathepsin D; D002403:Cathepsins / Q000378:metabolism*; D006980:Hyperthyroidism / Q000139:chemically induced / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D013965:Thyroidectomy; D014284:Triiodothyronine / Q000494:pharmacology*
D014284:Triiodothyronine; D002403:Cathepsins; D002402:Cathepsin D