Effects of H--Y antigen on morphologic and endocrine differentiation of gonads in mammals.
The effects of H--Y antigen, released in a soluble state by male human Burkitt lymphomas and mouse teratomas, were studied in the fetal gonads from 13 to 21-day-old rats and 98-day-old calves, using histologic techniques, radioimmunoassays for testosterone, and bioassays for Müllerian-inhibiting substance (MIS). Whereas no effect was detected in the younger gonads, some structural changes were observed in bovine and 21-day-old rat ovaries when cultured for 5 days with Daudi and male teratoma supernatants, but there was no synthesis of testosterone or MIS. These observations raise questions concerning the critical period of sensitivity to H--Y antigen of female gonads, and the dissociation between morphologic and biochemical events.
D000818:Animals; D002417:Cattle; D004477:Ectogenesis; D005260:Female; D005835:Genitalia / Q000196:embryology*; D006182:H-Y Antigen / Q000502:physiology*; D008297:Male; D009095:Mullerian Ducts / Q000502:physiology; D010053:Ovary / Q000196:embryology; D051381:Rats; D013737:Testis / Q000196:embryology; D013739:Testosterone / Q000378:metabolism
D006182:H-Y Antigen; D013739:Testosterone