Mineral fibre content of lung in mesothelial tumours: preliminary report.
A survey was made, through pathologists, of all 274 fatal cases of primary malignant mesothelioma in North America in 1972. For each case, a control with pulmonary metastases from a primary tumour other than lung cancer was matched for sex and age. Relatives and friends of both cases and controls were interviewed; and specimens of lung tissue were obtained for 100 case-control pairs and analysed 'blind' by electron microscopy and X-ray energy dispersion analysis. This report describes the preliminary results of the analyses of asbestos fibres in the first 37 case-control pairs: chrysotile fibres were far more prevalent than amphiboles, but equal quantities were found in cases and controls. There was, however, a clear excess of amosite fibres in male cases as compared with controls.
D001194:Asbestos / Q000009:adverse effects* / Q000032:analysis; D005260:Female; D006801:Humans; D008168:Lung / Q000032:analysis; D008175:Lung Neoplasms / Q000209:etiology / Q000401:mortality* / Q000556:secondary; D008297:Male; D008654:Mesothelioma / Q000209:etiology / Q000401:mortality*; D009656:North America; D009784:Occupational Diseases / Q000209:etiology / Q000401:mortality
D001194:Asbestos