Effect of glucose of growth hormone, prolactin and thyroid-stimulating hormone response to diazepam in normal subjects.
The effect of hyperglycemia on growth hormone, thyroid-stimulating hormone, and prolactin response to oral diazepam (10 mg) was assessed in 7 normal subjects. A peak growth hormone response of 13.5 +/- 0.3 ng/ml (mean +/- SEM) significantly above the base line (p less than 0.001) was achieved when diazepam was given alone. Hyperglycemia after glucose load abolished this response. There was no significant response of thyroid-stimulating hormone or prolactin after the administration of oral diazepam with and without glucose.
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D008297:Male; D011388:Prolactin / Q000097:blood*; D013972:Thyrotropin / Q000097:blood*
D001786:Blood Glucose; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone; D005947:Glucose; D003975:Diazepam