title: Influence of exercise on free amino acid concentrations in rat tissues.
abstract: Levels of free amino acids in muscle, liver, and plasma were measured in rats that had either swum (1 or 2 h) or run (until exhausted). Exercise lowered alanine levels in all three tissues except for liver of exhausted rats. Exercise decreased the plasma levels of the acidic amino acids and their amides. Glutamate and glutamine levels were depressed in muscle, and the glutamine level was lowered in liver by exercise. Aspartate concentration was lowered by exercise in liver but elevated in muscle. The branched-chain amino acids were generally elevated by exercise as were tyrosine, phenylalanine, methionine, and lysine. Plasma 3-methylhistidine concentration was also elevated by an exercise bout. The changes observed in the amino acid contents of muscle, liver, and plasma are consistent with the increase in protein degradation during exercise that we previously reported. The lowered levels of some amino acids (e.g., alanine, glutamine, glutamate) seem to suggest that amino acid catabolism and/or gluconeogenesis is increased by exercise.
mesh_terms: D000596:Amino Acids / Q000032:analysis* / Q000097:blood; D000818:Animals; D008099:Liver / Q000032:analysis; D008297:Male; D008762:Methylhistidines / Q000097:blood; D009132:Muscles / Q000032:analysis; D005082:Physical Exertion; D051381:Rats
chemical_list: D000596:Amino Acids; D008762:Methylhistidines; C028118:3-methylhistidine