Effect of substrates on the malonate inhibitory pattern and brefeldin A formation in Curvularia lunata.
The extracellular level of brefeldin A fluctuates with the length of malonate inhibition. Following treatment with malonate, mycelial multiplication as opposed to brefeldin A formation, was preferentially increased in the maleate, fumarate, succinate, citrate, methyl palmitate and glucose replacement cultures. Competitive maleate--malonate, fumarate--malonate, succinate--malonate and citrate--malonate-inhibited replacement cultures gave significantly higher mycelial and brefeldin A yields than the sole malonate-inhibited replacement cultures.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D020126:Brefeldin A; D002264:Carboxylic Acids / Q000378:metabolism; D003517:Cyclopentanes / Q000096:biosynthesis; D008314:Malonates / Q000494:pharmacology*; D003904:Mitosporic Fungi / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D002264:Carboxylic Acids; D003517:Cyclopentanes; D008314:Malonates; D020126:Brefeldin A