Inhibitor studies of phage T4 wild-type and mutant DNA polymerases. III. Distamycin A, actinomycin D, adriamycin, daunomycin and ethidium.
Adriamycin, daunomycin and ethidium, intercalating drugs which bind to double- as well as single-stranded DNA, inhibit phage T4 antimutator mutant CB121 DNA polymerase more strongly than the T4 wild-type and the mutator L98 polymerase. In contrast, all three enzymes are inhibited equally by distamycin A and actinomycin C. The latter two inhibitors bind only to double-stranded DNA.
D003609:Dactinomycin / Q000494:pharmacology; D003630:Daunorubicin / Q000494:pharmacology; D004214:Distamycins / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D004996:Ethidium / Q000494:pharmacology; D009154:Mutation; D019384:Nucleic Acid Synthesis Inhibitors; D013604:T-Phages / Q000201:enzymology* / Q000235:genetics
D004214:Distamycins; D019384:Nucleic Acid Synthesis Inhibitors; D003609:Dactinomycin; D004317:Doxorubicin; D004996:Ethidium; D003630:Daunorubicin