[Metalloporphyrin study in experimental carcinology (author's transl)].
Antitumoral effects and intratumoral concentrations of a metalloporphyrin were studied in mice with solid chemo-induced or transplanted tumors. The synthesis of this molecule was realised both with a stable metal (TPPS4SnCl2) (TPPS4InCl) and a radioactive metal (TPPS4(113)SnCl2) (TPPS4(111)InCl). The metal is introduced into the tetrapyrollic structure to give this molecule very high stability. The effect of the stable metalloporphyrin on tumoral kinetic parameters was analyzed. No tumoral regression was observed during the various experimental procedures. Even though radioactive molecules were found in the tumours, they were also present as high concentrations in the liver, spleen and kidneys, more than 72 hours after injection. Results are compared with those of various authors who used a molecule without metal, levels being measured by fluorescence in various organs and in the tumors. The interest of this metalled molecule in carcinology is discussed in relation to these new results.
D000818:Animals; D007553:Isotope Labeling; D008297:Male; D008665:Metalloporphyrins / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000378:metabolism; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism; D011166:Porphyrins / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000378:metabolism
D008665:Metalloporphyrins; D011166:Porphyrins; C016136:tetraphenylporphine sulfonate
Intérêt d'une métallo-porphyrine en cancérologie expérimentale.