title: A swine dysentery model for evaluation of drug prophylaxis: efficacy of various drugs in the control of swine dysentery.
abstract: A swine dysentery (SD) model that produces consistent, homogeneous, and severe SD was used in 2 experiments to compare the prophylactic effectiveness of 5 commercially available swine feed additive products. Under the conditions of these studies, carbadox and carbadox + sulfamethazine proved to be the most effective agents in preventing SD during the infection + medication and postmedication periods. Olaquindox was effective in preventing SD in the infection + medication period; however, SD recurrence was high during the postmedication period. Nithiamide and chlortetracycline + sulfamethazine + penicillin were least effective in preventing SD during the infection + medication and postmedication periods.
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents; D002218:Carbadox / Q000627:therapeutic use; D002751:Chlortetracycline / Q000627:therapeutic use; D003497:Cyclic N-Oxides / Q000627:therapeutic use; D004341:Drug Evaluation; D004403:Dysentery / Q000517:prevention & control / Q000662:veterinary*; D010406:Penicillins / Q000627:therapeutic use; D011810:Quinoxalines / Q000627:therapeutic use; D013418:Sulfamethazine / Q000627:therapeutic use; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*; D013844:Thiazoles / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D003497:Cyclic N-Oxides; D010406:Penicillins; D011810:Quinoxalines; D013844:Thiazoles; D013418:Sulfamethazine; C004474:nithiamide; C013168:olaquindox; D002218:Carbadox; D002751:Chlortetracycline