Immunization with purified myelin-associated glycoprotein does not evoke myelination-inhibiting or demyelinating antibodies.
Antisera produced in rabbits against purified myelin-associated glycoprotein did not inhibit myelin formation in cerebellar tissue cultures or demyelinate centrally or peripherally myelinated fibers in spinal cord-dorsal root ganglia cultures. These results suggest that antibodies directed against other myelin components are responsible for the myelination-inhibition and demyelination produced by anti-central nervous system (CNS) and anti-myelin antisera in vitro.
D000818:Animals; D000917:Antibody Formation; D046508:Culture Techniques; D006023:Glycoproteins / Q000276:immunology*; D051379:Mice; D009185:Myelin Proteins / Q000276:immunology*; D009186:Myelin Sheath / Q000276:immunology*; D009413:Nerve Fibers, Myelinated / Q000276:immunology; D011817:Rabbits
D006023:Glycoproteins; D009185:Myelin Proteins