[Pharmacokinetics of etomidate in man (author's transl)].
The pharmacokinetic behaviour of etomidate was investigated in 7 patients. A method for the analysis of etomidate is described using gas-liquid chromatography for separation and alkali flame ionization detection. The lower limit of detection for etomidate in plasma was 0.005 microgram/ml. The pharmacokinetic behaviour of etomidate after an intravenous bolus injection of 20 mg may be described in terms of an open two-compartment model. The plasma half-life of etomidate was in the alpha-phase about 3 minutes, the biological half-life of the beta-phase was about 70 minutes. The total volume of distribution was calculated at 165 litres. The total plasma clearance amounted to 1600 ml/min. These pharmacokinetic data were used to establish an intravenous infusion scheme for etomidate.
D000368:Aged; D002849:Chromatography, Gas; D005045:Etomidate / Q000097:blood*; D006207:Half-Life; D006801:Humans; D007093:Imidazoles / Q000097:blood*; D007700:Kinetics; D008875:Middle Aged; D008954:Models, Biological
D007093:Imidazoles; D005045:Etomidate
Pharmakokinetische Untersuchungen über Etomidat beim Menschen.