Uraniosomes produced in the synovial membrane by uranyl acetate.
Uranyl acetate was injected into the rabbit knee joint. This produced single-membrane-bound presumably lysosmal bodies (called 'uraniosomes') containing electron-dense crystals in Type A and Type B synovial intimal cells, subsynovial macrophages and lipocytes. Uranium deposits were also seen in the extracellular matrix. All uraniosomes and extracellular deposits analysed by electron-probe X-ray analysis were found to contain uranium, potassium and phosphorus. Traces of calcium and sulphur were also found in some of the uraniosomes and extracellular uranium deposits.
D000818:Animals; D003593:Cytoplasm / Q000648:ultrastructure*; D003599:Cytoskeleton / Q000648:ultrastructure; D008264:Macrophages / Q000648:ultrastructure; D009940:Organoids / Q000032:analysis / Q000648:ultrastructure*; D009942:Organometallic Compounds; D011817:Rabbits; D013583:Synovial Membrane / Q000378:metabolism* / Q000648:ultrastructure; D014501:Uranium / Q000032:analysis / Q000378:metabolism*
D009942:Organometallic Compounds; C005460:uranyl acetate; D014501:Uranium