title: [Problems of therapy control in arthroses and suggestion of a method for the non-invasive identification of changes in joint morphology (knee joint) (author's transl)].
abstract: The article explains the fundamental problems in therapeutic studies of the primary and secondary processes in arthrosis. Many drugs are on the market for treating the secondary phenomena; however, such phenomena can often be assessed only on the basis of "soft" action criteria (verbal information given by the patients). Biochemical examinations of the synovial fluid and methods to assess joint morphology, are particularly suitable for evaluating the primary changes taking place in the joint cartilage. An assessment of the "joint noises" is known in literature as a non-invasive method. An improved method of recording and evaluating these joint noises is suggested. It is characterized by the following features: - registration of signals with defined joint load - classification of the noise phenomena with reference to the joint position, i.e. to joint areas - by separation of the signal into movement cycles elimination of artificial noise producers - evaluation of those signal periods only which are disease-specific. The article shows examples by quoting signals with the respective frequencies for healthy and diseased persons, and explains the suitability of the method in therapy control by describing two examples of surgical treatment.
mesh_terms: D006801:Humans; D007592:Joint Diseases / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D007719:Knee Joint / Q000503:physiopathology; D013016:Sound
vernacular_title: Probleme der Therapiekontrolle bei Arthrosen und Vorschlag eines Verfahrens zur nicht-invasiven Erfassung von Vernderungen der Gelenkmorphologie (Kniegelenk).