Pharmacotherapeutics of chloramphenicol in veterinary medicine.
Since its discovery in 1947, chloramphenicol has enjoyed a prominent place in the veterinarian's drug arsenal. Some of the reasons for its popularity are: (1) Antimicrobial activity--effective against a variety of infective pathogens, including staphylococci, salmonellae, pasturellae, Bordetella, Haemophilus, coliform organisms, chlamydiae, and rickettsiae, many of which may be resistant to other antimicrobial agents; (2) Kinetic properties--allowing production and maintenance of effective therapeutic concentrations in body fluids and tissues, with a practicable dosage schedule in most species; (3) Safety--toxic reactions to chloramphenicol encountered thus far in animals have not warranted any serious limitations on its use in veterinary medicine.
D000820:Animal Diseases / Q000188:drug therapy*; D000818:Animals; D001711:Biotransformation; D002415:Cats; D002701:Chloramphenicol / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D005128:Eye Diseases / Q000188:drug therapy / Q000662:veterinary; D007700:Kinetics; D012871:Skin Diseases / Q000188:drug therapy / Q000662:veterinary
D002701:Chloramphenicol