A high level of glycosaminoglycan-synthesis of squamous cell carcinoma of the parotid gland.
Glycosaminoglycan content of a squamous cell carcinoma derived from the parotid gland was analyzed. The tumor tissue contained a large amount of glycosaminoglycans, and the amount was strikingly larger than found in other kinds of tumor tissues (pleomorphic adenoma, scirrhous carcinoma, myxoma, etc.) analyzed previously. A culture cell line established from this tumor showed a morphologic characteristic of differentiated squamous cell carcinoma, in vitro, forming many tonofilaments in the cytoplasma and numerous desmosomes in the intercellular connection. The carcinoma cell synthesized and secreted a large amount of glycosaminoglycans, consisting mainly of hyaluronic acid. The amount of 3H-labelled hyaluronic acid secreted by this carcinoma cell was about 20-fold larger than that by HeLa cell or KB cell. Conceivably, a high level of hyaluronic acid synthesis is one of the biologic characteristics of squamous cell carcinoma derived from the duct epithelium of the salivary gland.
D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D002460:Cell Line; D006025:Glycosaminoglycans / Q000032:analysis / Q000096:biosynthesis*; D006367:HeLa Cells; D006801:Humans; D006820:Hyaluronic Acid / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000378:metabolism*; D012468:Salivary Gland Neoplasms / Q000378:metabolism
D006025:Glycosaminoglycans; D006820:Hyaluronic Acid