A role for calcium in the acute and chronic actions of ethanol in vitro.
Ethanol, in a concentration of 40--160 mM, depressed the electrically evoked contractions of the guinea-pig ileum longitudinal muscle/myenteric plexus (LM/MP) preparation in a dose-dependent manner. The acute ethanol inhibition in vitro was partially reversed by raising the extracellular calcium concentration. Following a 4 week ethanol treatment in vivo, by means of daily i.p. injections, the LM/MP preparation was rendered tolerant to ethanol and at the same time calcium was more effective in reversing the inhibitory effect of ethanol. It appears that calcium plays a role in the acute action of, and development of tolerance to, ethanol.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction
D000431:Ethanol; D002118:Calcium