Radiolabeled benzoylcholine derivatives as possible myocardial-imaging agents.
Two radioiodinated analogs of benzoylcholine were investigated as possible myocardial-imaging agents. O-([2-125I]Iodobenzoyl)-choline and N-([2-125I]iodobenzoyl)cholamine were prepared by nucleophilic substitution of sodium [125I]iodide for stable iodine in O-(N,N]dimethylaminoethyl)-2-iodobenzoate and N-(N',N'-dimethylaminoethyl)-2-iodobenzamide, respectively, and by methylation with methyl iodide. The in vivo distribution of each compound in mice was determined as a function of time. Favorable heart-to-blood and heart-to-lung ratios were obtained with N-([2-125I]iodobenzoyl)cholamine.
D000818:Animals; D001588:Benzoylcholine / Q000031:analogs & derivatives* / Q000378:metabolism; D002794:Choline / Q000031:analogs & derivatives*; D006321:Heart / Q000000981:diagnostic imaging*; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D051379:Mice; D011877:Radionuclide Imaging; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D001588:Benzoylcholine; D002794:Choline