title: A methotrexate insensitive variant of folate reductase present in two lines of methotrexate-resistant L5178Y cells.
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002846:Chromatography, Affinity; D002851:Chromatography, High Pressure Liquid; D004351:Drug Resistance; D005493:Folic Acid Antagonists; D014644:Genetic Variation; D007700:Kinetics; D007940:Leukemia L5178 / Q000201:enzymology* / Q000473:pathology; D007942:Leukemia, Experimental / Q000201:enzymology*; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D005493:Folic Acid Antagonists; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate