Spatial organization of histones and DNA in the nucleosome core particle: a model.
We present here an attempt to build up a space-filling model of the nucleosome core particle based on the chemical crosslinking data of Mirzabekov and co-workers (23). It is shown that the models proposed earlier are inconsistent with the results of these authors. The main characteristics of our model are as follows: a) the DNA superhelix contains at least 90 base pairs (bp) per turn; b) the particle has a dyad axis of symmetry; c) the histone octamer may be regarded as consisting of two heterotypic tetramers. The possible shape and function of core histones are discussed in the light of the model.
D004247:DNA; D006657:Histones; D008958:Models, Molecular; D009707:Nucleosomes / Q000648:ultrastructure*
D006657:Histones; D009707:Nucleosomes; D004247:DNA