title: Twice-a-day fractionation preoperative radiotherapy in patients with carcinoma of the bladder: preliminary report.
abstract: There were 13 patients with carcinoma of the bladder who received preoperative radiotherapy by a modified regimen before cystectomy. Doses of 135 rad were delivered twice daily for 10 days (2,700 rad) to a 15 times 15 cm. portal and followed by immediate cystectomy. Patient tolerance has been excellent, morbidity has been minimal and no increase in operative time, blood loss of major intraoperative or postoperative complications has ensued. The theoretical and practical advantages of this regimen may outweight either the standard regimen of 4,500 rad with a 4-week hiatus before operation or the high dose, short course regimen of 2,000 rad in 5 days and immediate cystectomy.
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011879:Radiotherapy Dosage; D001743:Urinary Bladder / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000532:radiotherapy* / Q000601:surgery