title: Amino acid sequence of the blood group Mg-specific major human erythrocyte membrane sialoglycoprotein.
abstract: The structure of the N-terminal 21 residues of the blood group Mg-specific major human erythrocyte membrane sialoglycoprotein was investigated, using tryptic MgM peptides and secondary fragments prepared by staphylococcal V8 protease treatment. The sequence Leu-Ser-Thr-Asn-Glu was obtained for the N-terminal five residues. Therefore, the Mg gene appears to have evolved from a Thr leads to Asn mutation of an N allele. This alteration was found to prevent the glycosylation of the amino acids at the second and third positions.
mesh_terms: D000595:Amino Acid Sequence; D001789:Blood Group Antigens / Q000032:analysis*; D004910:Erythrocyte Membrane / Q000032:analysis*; D004912:Erythrocytes / Q000032:analysis*; D006801:Humans; D010446:Peptide Fragments / Q000032:analysis; D012795:Sialoglycoproteins / Q000097:blood*
chemical_list: D001789:Blood Group Antigens; D010446:Peptide Fragments; D012795:Sialoglycoproteins