[The pharmacokinetics of adriamycin and adriamycin-metabolites (author's transl)].
A sensitive reproducible, nondestructive method for the determination of adriamycin and its metabolites in plasma, leukocytes and tissues has been developed. Apolar substances as adriamycinone (adm-one) were extracted at pH 2 with chloroform, polar ones as adriamycin (adm) and adriamycinol (adm-ol) at pH 8.8 with chloroform: methanol, separated by thin-layer-chromatography and quantitated by fluorescence spectrophotometry. The plasma levels of adm-ol and adm-one were lower in all patients compared to those of adm. Further metabolites were found in the bile. Toxic effects were found in patients with prolonged half-lives in the elimination phase. A delayed elimination was observed in a patient with an elevation of the bilirubin level, but also in patients without overt liver disease. The pharmacokinetics of adm showed considerable inter- and intraindividual fluctuations.
D002855:Chromatography, Thin Layer; D004317:Doxorubicin / Q000009:adverse effects / Q000031:analogs & derivatives / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D007962:Leukocytes / Q000032:analysis; D009279:Naphthacenes / Q000032:analysis / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D014018:Tissue Distribution
D009279:Naphthacenes; C010012:adriamycin aglycone; D004317:Doxorubicin; C010013:adriamycinol
Die Pharmakokinetik von Adriamycin und Adriamycin-Metaboliten.