Delayed hypersensitivity to syngeneic or xenogeneic testicular cells in guinea-pigs.
Guinea-pigs of an inbred JY-l strain were immunized with syngeneic or xenogeneic testicular cells without added adjuvants. A delayed erythematous skin reaction accompanied by basophil infiltration was detected after elicitation with syngeneic testicular cells and the erythematous reaction was augmented by treatment with cyclophosphamide before immunization. Cross-reactivity was observed among testicular cells of the guinea-pig, rat or mouse at the levels of immunization and elicitation.
D000818:Animals; D001491:Basophils; D003429:Cross Reactions; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology* / Q000473:pathology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000473:pathology; D012882:Skin Tests; D013737:Testis / Q000166:cytology / Q000276:immunology*
D003520:Cyclophosphamide