Diazepam infusion in tetanus: correlation of drug levels with effect.
A patient with muscle spasms and rigidity associated with tetanus was successfully treated with a continuous infusion of diazepam. This beneficial response was associated with a minimal serum diazepam concentration of 500 ng/ml. The major metabolite of diazepam, DMD, did not appear to exert substantial activity. Guidelines for dosing diazepam are provided.
D000328:Adult; D003975:Diazepam / Q000008:administration & dosage* / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D013742:Tetanus / Q000188:drug therapy*
D003975:Diazepam