The anticoagulant activity of dermatan sulphates: evidence against the involvement of antithrombin III.
Anticoagulant activity of dermatan sulphates is unaffected by antiserum specific for antithrombin III (AT III) unless the glycosaminoglycan preparation contains demonstrable heparin. 2 Only dermatan sulphate preparations of considerable heparin content potentiate AT III inhibition of thrombin, factor Xa and plasmin. 3 These data suggest that dermatan sulphates exert anticoagulant activity which, unlike that of heparin, is largely or totally independent of AT III.
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D000990:Antithrombin III / Q000502:physiology*; D002417:Cattle; D002807:Chondroitin / Q000031:analogs & derivatives*; D003871:Dermatan Sulfate / Q000494:pharmacology*; D006493:Heparin / Q000502:physiology; D007106:Immune Sera / Q000494:pharmacology; D011480:Protease Inhibitors / Q000494:pharmacology; D013552:Swine; D013918:Thrombin Time
D000925:Anticoagulants; D007106:Immune Sera; D011480:Protease Inhibitors; D003871:Dermatan Sulfate; D000990:Antithrombin III; D006493:Heparin; D002807:Chondroitin