Differential electrophysiological and behavioral responses to optically active derivatives of phencyclidine.
Dextro- and levorotatory isomers of 1-(1-phenylcyclohexyl)-3-methylpiperidine (PCMP) were synthesized. Both isomers inhibited spontaneous cerebellar Purkinje neuron firing when applied locally by pressure ejection. This effect was dose-dependent, with the (+)-isomer about 5--7 times more potent than the (-)-isomer. Both isomers also depressed rotarod performance in mice. Again, the (+)-isomer was about 5 times more potent than the (-)-isomer. Both rotarod performance and Purkinje cells discharge were depressed maximally 10--15 min after i.p. injection of drug. Our results suggest a correlation between behavioral performance and central neuron electrophysiological activity and suggest that the central actions of PCP or its derivatives are probably mediated at one locus, by a stereospecific mechanism.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004594:Electrophysiology; D008297:Male; D051379:Mice; D010622:Phencyclidine / Q000494:pharmacology*; D004856:Postural Balance / Q000187:drug effects; D011689:Purkinje Cells / Q000187:drug effects*; D051381:Rats; D013237:Stereoisomerism; D013997:Time Factors
D010622:Phencyclidine