Ocular aldehyde dehydrogenase in rodents.
The presence of NAD-dependent ocular aldehyde dehydrogenase in rodents is reported. The enzyme is species and strain-dependent. Ocular ALDH possesses a significantly greater specific activity than that of the hepatic tissue of the species studied. d-Amphetamine non-competitively inhibited rat eye ALDH in vitro. Short-term administration of cyclobenzaprine, a tricyclic compound with muscle relaxant property, induced ocular aldehyde dehydrogenase. This is compared with lack of effect of certain CNS-stimulants, ethanol intake and of a monoamine oxidase inhibitor on endogenous ALDH in vivo.
D000444:Aldehyde Dehydrogenase; D000445:Aldehyde Oxidoreductases / Q000032:analysis*; D000818:Animals; D006224:Cricetinae; D000431:Ethanol / Q000494:pharmacology; D005123:Eye / Q000201:enzymology*; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D000431:Ethanol; D000445:Aldehyde Oxidoreductases; D000444:Aldehyde Dehydrogenase