Allergic reaction to an amide local anaesthetic.
A 67-yr-old female patient gave a history of allergy to lignocaine. When she was challenge-tested with the intradermal injection of 0.5% bupivacaine 0.2ml she had a systemic reaction. This reaction was accompanied by a decrease in the concentration of complement C4 in the plasma, which indicated that the reaction was immunologically-mediated. This is the first report of allergy to a local anaesthetic drug which has been documented by concurrent immunological changes.
D000368:Aged; D002045:Bupivacaine / Q000009:adverse effects*; D003181:Complement C4 / Q000032:analysis; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000276:immunology; D005260:Female; D006801:Humans; D007428:Intradermal Tests
D003181:Complement C4; D002045:Bupivacaine