title: Propranolol antagonizes phencyclidine-induced hyperactivity and stereotypy in rats.
abstract: The single and combined effects of acute phencyclidine (PCP) and propranolol, each given intraperitoneally, were studied on rat behavior. PCP (5, 10, 25, 50, and 100 mg/kg) produced dose-related stereotypy and increases in (photocell) hyperactivity over 4 h observation. Propranolol (10 and 25 mg/kg) neither caused any stereotypy nor had any effect on activity relative to vehicle control. Additionally, propranolol (10 and 25 mg/kg), given 30 min after PCP (10, 25 and 50 mg/kg), reduced or completely blocked the stereotypy and hyperactivity caused by PCP. These data provide the first experimental verification of a clinical observation that propranolol may be an effective antagonist of the behavioral toxicity produced by PCP.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006948:Hyperkinesis / Q000139:chemically induced*; D010622:Phencyclidine / Q000037:antagonists & inhibitors*; D011433:Propranolol / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects*
chemical_list: D011985:Receptors, Serotonin; D011433:Propranolol; D010622:Phencyclidine