Effect of modification of one histidine residue on the enzymatic and pharmacological properties of a toxic phospholipase A2 from Naja nigricollis snake venom and less toxic phospholipases A2 from Hemachatus haemachatus and Naja atra snake venoms.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004546:Elapid Venoms / Q000032:analysis*; D004912:Erythrocytes / Q000187:drug effects; D006168:Guinea Pigs; D006639:Histidine; D006868:Hydrolysis; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010740:Phospholipases / Q000494:pharmacology*; D010741:Phospholipases A / Q000378:metabolism / Q000494:pharmacology*; D054467:Phospholipases A2; D010743:Phospholipids; D051381:Rats; D012910:Snake Venoms / Q000032:analysis*; D013329:Structure-Activity Relationship
D004546:Elapid Venoms; D010743:Phospholipids; D012910:Snake Venoms; C026012:hemachatus venom; D006639:Histidine; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2