Protective effect of a new antioxidant on acute hepatotoxicity caused by morpholine plus nitrite in rats.
Bis(2,2-dimethyl-4-methane sulphonic acid sodium salt-1,2-dihydroquinoline)-6,6'-methane (MTDQ-DA), a new, non-toxic, water soluble antioxidant, is shown to inhibit liver necrosis induced in rats by N-nitrosomorpholine (N-MOR), itself formed in vivo following the administration simultaneously of morphine (MOR) and sodium nitrite (NaNO2).
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009025:Morpholines / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009336:Necrosis; D009573:Nitrites / Q000037:antagonists & inhibitors*; D009602:Nitrosamines / Q000378:metabolism; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats; D012977:Sodium Nitrite / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000975:Antioxidants; D009025:Morpholines; D009573:Nitrites; D009602:Nitrosamines; D011804:Quinolines; C002741:N-nitrosomorpholine; C011923:6,6'-methylene bis(2,2,4-trimethyl-1,2-dihydroquinoline); D012977:Sodium Nitrite