title: Characterization of murine erythroid progenitors with high erythropoietin sensitivity in vitro.
abstract: The microplasma clot culture system was employed to study the characteristics of late murine erythroid progenitor cells. Erythroid cluster and colony-forming cells (CFUE) were compared with regard to erythropoietin sensitivity, cell-cycle activity, response to hypertransfusion-induced plethora, average cell size, temporal kinetics of in vitro cluster or colony formation, and relative frequency in murine bone marrow. Results indicate that erythroid cluster-forming cells represent a stage of differentiation which is further along the erythroid pathway than CFUE and are nearly 6-fold more sensitive to the hormone.
mesh_terms: D000818:Animals; D001799:Blood Sedimentation; D002453:Cell Cycle; D002454:Cell Differentiation; D002455:Cell Division; D003114:Colony-Forming Units Assay; D004912:Erythrocytes / Q000166:cytology; D004921:Erythropoietin / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D011086:Polycythemia / Q000097:blood; D013997:Time Factors
chemical_list: D004921:Erythropoietin