Prevention of postoperative pancreatic fistulae by intraductal injection of a tissue-adhesive polymer.
Ligation of the intact horizontal segment of the pancreas in 8 dogs caused enlargement and then atrophy of the gland. Ligation of dissected pancreases in 9 dogs caused pseudocysts, fistulae and pancreatic ascites in 6. Ligation following obliteration of the ductal system with cyanoacrylate tissue adhesive in 8 dissected pancreases caused no pancreatic complications. Both ligation and obliteration reduced the glucose consumption coefficient (k-value) below the preoperative levels (p less than 0.01), there was no difference, however, between the two methods as far as glucose consumption is concerned. Ductal obliteration might prevent the development of pancreatic fistulae following the Whipple procedure offering an alternative to either simple ligation or pancreatojejunostomy.
D000818:Animals; D003487:Cyanoacrylates / Q000627:therapeutic use*; D004285:Dogs; D004386:Duodenum / Q000601:surgery; D010180:Pancreatectomy / Q000009:adverse effects / Q000379:methods*; D010183:Pancreatic Ducts / Q000601:surgery*; D010185:Pancreatic Fistula / Q000517:prevention & control*; D010192:Pancreatic Pseudocyst / Q000209:etiology; D011183:Postoperative Complications / Q000517:prevention & control
D003487:Cyanoacrylates