Effect of DLF lesions at different spinal levels on morphine induced analgesia.
The effect of morphine on tail flick latency was tested in 3 groups of rats. It is shown that in normal rats and in rats with a bilateral DLF lesion at Th10 or lower spinal root segments, morphine increased the tail flick latency. After a bilateral DLF lesion at Th9 or higher segments, morphine did not change the tail flick latency.
D000818:Animals; D009020:Morphine / Q000494:pharmacology*; D009433:Neural Inhibition / Q000187:drug effects*; D009434:Neural Pathways / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D012023:Reflex, Monosynaptic / Q000187:drug effects; D013116:Spinal Cord / Q000502:physiology*
D009020:Morphine