Ionic conductance and experimentally induced myotonia.
Experiments were conducted to study the effect of altering external potassium on in vitro induction of myotonia in rat diaphragm using 2,4-dichlorophenoxy acetate (2,4-D). An increase in external potassium inhibited, while a decrease enhanced, the myotonic response. However, in preparations which have undergone prior denervation, there was no myotonic response to 2,4-D, even when the external potassium was lowered. The experiments also support the existence of neural factors influencing the resting ionic conductance of the muscle membrane.
D015084:2,4-Dichlorophenoxyacetic Acid / Q000494:pharmacology; D000818:Animals; D003964:Diaphragm / Q000187:drug effects / Q000503:physiopathology; D009119:Muscle Contraction / Q000187:drug effects; D009222:Myotonia / Q000139:chemically induced / Q000503:physiopathology*; D011188:Potassium / Q000494:pharmacology; D051381:Rats
D015084:2,4-Dichlorophenoxyacetic Acid; D011188:Potassium