title: Sexual dysfunction and clomipramine.
abstract: Three cases of orgasmic inhibition by clomipramine are reported, one in a male and two in females. All were depressed patients with obsessive-compulsive features. Orgasmic dysfunction manifested shortly after beginning clomipramine therapy despite a return of libido as the depression lifted. Two of these patients switched to desipramine which led to a resolution of sexual dysfunction while maintaining the patients depression free. The third patient manipulated dosage times to diminish the orgastic problem. Strong anticholinergic and/or anti-adrenergic properties of clomipramine are suspected to underlie the development of this problem.
mesh_terms: D000328:Adult; D002997:Clomipramine / Q000009:adverse effects* / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy; D004334:Drug Administration Schedule; D004542:Ejaculation / Q000187:drug effects; D007172:Erectile Dysfunction / Q000139:chemically induced / Q000523:psychology; D005260:Female; D005687:Galactorrhea / Q000139:chemically induced; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy; D009948:Orgasm / Q000187:drug effects; D011247:Pregnancy; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced*
chemical_list: D002997:Clomipramine