Serum level of phenobarbital or/and diphenylhydantoin in epileptics with some preexisting serum lipid alterations. Correlations with the treatment efficiency in epilepsy.
In a group of 38 epileptics, 13.1 % had alterations of serum lipids before administration of antiepileptic therapy. An inverse relation was found between the level of serum lipids and that of drug concentration : on minimal daily doses, phenobarbital attained disproportionally high concentrations in a patient with hypocholesterolemia + hypotriglyceridemia, while on large daily doses phenobarbital and/or diphenylhydantoin attained low concentrations in the patients with hypercholesterolemia alone or accompanied by hypertriglyceridemia.
D000328:Adult; D002784:Cholesterol / Q000097:blood; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000097:blood* / Q000627:therapeutic use; D010672:Phenytoin / Q000097:blood* / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood
D008055:Lipids; D014280:Triglycerides; D010672:Phenytoin; D002784:Cholesterol; D010634:Phenobarbital