Central sympathetic reactivity inhibited by indoramin.
The action of indoramin on central autonomic activity was investigated using the sympathetic-cholinergic electrodermal response system. Indoramin (0.33-10 mg/kg, i.v.) significantly reduced the amplitude of electrodermal responses (EDR) evoked by stimulation of the hypothalamus in a dose-related manner. The CNS effects of indoramin on the EDR were partially antagonized by yohombine pretreatment. These results demonstrate that indoramin reduces central sympathetic reactivity and suggest that an alpha-adrenergic inhibitory mechanism may be involved.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D002415:Cats; D004305:Dose-Response Relationship, Drug; D005260:Female; D007211:Indoles / Q000494:pharmacology*; D007217:Indoramin / Q000494:pharmacology*; D008297:Male; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology; D015016:Yohimbine / Q000494:pharmacology
D007211:Indoles; D007217:Indoramin; D015016:Yohimbine