title: Pheochromocytoma: an animal model.
abstract: A reproducible animal model for studying pheochromocytoma is described. Rat pheochromocytoma cells (PC-12 line) maintained in tissue culture and injected subcutaneously into rats produce a functioning tumor at the side of inoculation. Animals harboring these tumors develop alterations characteristic of pheochromocytoma including weight loss, hypertension and a contracted blood volume. This model provides an easily reproducible system for studying the pathophysiologic features of pheochromocytoma.
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000503:physiopathology*; D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume; D001835:Body Weight; D002395:Catecholamines / Q000097:blood; D002460:Cell Line; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D010673:Pheochromocytoma / Q000503:physiopathology*; D051381:Rats; D012737:Sex Factors
chemical_list: D002395:Catecholamines