Tryptic peptide map analyses of mouse transplantation antigens.
Tryptic peptide map analyses of five K- and three D-gene products of various H-2 haplotypes are presented. These data support earlier sequence studies and demonstrate that the variations in allelic gene products of the K or D loci are scattered throughout much of the polypeptide chains. Furthermore, the K allelic gene products are no more closely related to one another than they are to the D allelic gene products. This apparent lack of K-ness and D-ness places interesting constraints on the genetic organization and evolutionary history of the genes encoding the transplantation antigens.
D000596:Amino Acids; D000818:Animals; D001120:Arginine; D011232:Chemical Precipitation; D002852:Chromatography, Ion Exchange; D006183:H-2 Antigens; D006649:Histocompatibility Antigens / Q000032:analysis*; D051379:Mice; D008805:Mice, Inbred A; D008809:Mice, Inbred C3H; D010455:Peptides / Q000235:genetics*; D014357:Trypsin / Q000494:pharmacology*
D000596:Amino Acids; D006183:H-2 Antigens; D006649:Histocompatibility Antigens; D010455:Peptides; D001120:Arginine; D014357:Trypsin