title: [Clinical importance of the electron microscopic study of muscle biopsies in myasthenia during prednisolone therapy].
abstract: An observation of a patient with malignant generalised myasthenia treated for 5 years with surgical methods (thymectomy, glomectomy) as well as with ACTH, immunosuppressors and prednisolone is described. Before prednisolone therapy and 2 years after it muscle biopsies were taken to control the effectiveness of the therapy given. Electron microscopic examination of the second biopsy revealed predominance of muscle regeneration processes over atrophy and destruction in the absence of clinical signs of recovery.
mesh_terms: D000328:Adult; D001706:Biopsy; D002908:Chronic Disease; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D009132:Muscles / Q000648:ultrastructure*; D009157:Myasthenia Gravis / Q000188:drug therapy / Q000473:pathology*; D009469:Neuromuscular Junction / Q000648:ultrastructure; D011239:Prednisolone / Q000627:therapeutic use*; D012121:Respiration, Artificial
chemical_list: D011239:Prednisolone
vernacular_title: Klinicheskoe znachenie élektronno-mikroskopicheskogo issledovaniia bioptatov myshtsy pri miastenii v usloviiakh lecheniia prednizolonom.