A comparison of the anthelmintic effects of oxfendazole and oxibendazole on Trichinella spiralis in mice.
Oxfendazole was shown to be a very potent agent in killing Trichinella spiralis. A single dose of 1.6 mg/kg per os killed 99% of preadults. Adults were much more resistant; 25 mg/kg killed 56%, even 3,200 mg/kg only killed 94%. Developing and encysted muscle larvae were also killed; 7 X 50 mg/kg killed 99% and 98%, respectively. Oxibendazole was less effective. 6.25 mg/kg killed 99% of preadults, and 3,200 mg/kg killed only 69% of adults. Although oxibendazole also killed developing and encysted muscle larvae, much higher dosages were required; 7 X 200 mg/kg killed 99% of developing larvae and 82% of encysted larvae.
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D002219:Carbamates / Q000494:pharmacology*; D007814:Larva; D051379:Mice; D009132:Muscles / Q000469:parasitology; D014234:Trichinella / Q000187:drug effects*; D014235:Trichinellosis / Q000469:parasitology
D000871:Anthelmintics; D001562:Benzimidazoles; D002219:Carbamates; C011321:oxibendazole; C011030:oxfendazole