Effect of a single oral dose of DDT on lipid metabolism in rat.
A single oral dose of 1,1,1-trichloro-2-2-bis (p-chlorophenyl)ethane (DDT) (600 mg/kg body weight) was given to rats and the levels of various lipids in adipose tissue, liver and plasma were studied. No alteration was observed in the levels of various lipid classes in these tissues except for a decrease in the phospholipid and triglyceride fractions in liver. Lipoprotein lipase activity of post-heparin plasma (protamine-sensitive and -resistant) was significantly decreased, whereas in liver and adipose tissue, the activity of this enzyme remained unchanged.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D003634:DDT / Q000633:toxicity*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008071:Lipoprotein Lipase / Q000037:antagonists & inhibitors / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats
D008055:Lipids; D003634:DDT; D008071:Lipoprotein Lipase