[The dynamics of the drug release from tablets. Part 7: Comparison of three liberation models on Cholestil tablets (author's transl)].
The liberation of hymecromone from Cholestil tablets (0.2 g) has been determined by three procedures; half-change method, stationary-basket method, and rotating-basket method. The release rate was highest when determined by the rotating-basket method. The other two methods yielded comparable, but considerably lower values. Artificial gastric and intestinal juices according to the Polish Pharmacopoeia IV have been used in this study.
D002626:Chemistry, Pharmaceutical; D006923:Hymecromone; D008962:Models, Theoretical; D012995:Solubility; D013607:Tablets; D014468:Umbelliferones
D013607:Tablets; D014468:Umbelliferones; D006923:Hymecromone
Dynamik der Arzneimittelabgabe aus Tabletten. 7. Mitteilung: Vergleich von drei Liberationsmodellen am Beispiel der Cholestil-Tabletten.