Two large glycoprotein fragments related to the NH2-terminal part of the adrenocorticotropin-beta-lipotropin precursor are the end products of the maturation process in the rat pars intermedia.
Pulse and pulse-chase studies of the peptide hormones synthesized in the rat pars intermedia showed that during the maturation of pro-opiomelanocortin (the adrenocorticotropin-beta-lipotropin (ACTH-beta-LPH) precursor) the N-terminal portion of the precursor was released as a glycopeptide of relative mass of 17 000 - 19 000 and did not undergo further proteolytic cleavage. This peptide is therefore proposed to be the biologically active species related to the amino terminal fragment of pro-opiomelanocortin in the rat pars intermedia.
D000818:Animals; D006023:Glycoproteins / Q000032:analysis*; D010902:Pituitary Gland / Q000032:analysis*; D010908:Pituitary Hormones, Anterior / Q000032:analysis*; D011333:Pro-Opiomelanocortin; D011498:Protein Precursors / Q000032:analysis*; D051381:Rats
D006023:Glycoproteins; D010908:Pituitary Hormones, Anterior; D011498:Protein Precursors; D011333:Pro-Opiomelanocortin