[Sensitivity of several commercial thromboplastins to non-carboxylated clotting factors II and X (author's transl)].
All reagents for determination of thromboplastin time (Quick-test) tested so far are sensitive to non-carboxylated clotting factor X, and sensitivity varies, depending on the reagent. The thromboplastins of Behring and Thrombotest are very sensitive. The preparations of La-Roche and Boehringer are somewhat more sensitive than those of Dade and Goedecke. Only the differences between the first group (Behring, Thrombotest) and the others are significant. There is a good correlation between factor X sensitivity, prothrombin time and non-carboxylated clotting factor X sensitivity, with all reagents. These results may be of significance for quality control and standardization of the prothrombin time.
D015415:Biomarkers; D005170:Factor X / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D010644:Phenprocoumon / Q000494:pharmacology; D011498:Protein Precursors; D011516:Prothrombin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D011517:Prothrombin Time; D013925:Thromboplastin / Q000592:standards*
D015415:Biomarkers; D011498:Protein Precursors; C008208:acarboxyprothrombin; D011516:Prothrombin; D005170:Factor X; D013925:Thromboplastin; D010644:Phenprocoumon
Einfluss von Vorstufen von Faktor II oder Faktor X auf den Quick-Wert bei Verwendung von Thromboplastinen verschiedener Hersteller.