[Identification of a third S-containing metabolite of 1-allyl-3,5-diethyl-6-chlorouracil and mechanism of formation of SCH3-metabolites (author's transl)].
A new S-containing metabolite of 1-allyl-3,5-diethyl-6-chlorouracil is reported. By comparison with a synthetic product, this metabolite could be identified as 6,8-diethyl-2-hydroxymethyl-tetrahydrothiazolo-[3,2-c]pyrimidine-5,7 (4H,6H)-dione. The mechanism of the formation of S-containing metabolites is discussed.
D000818:Animals; D001711:Biotransformation; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D011817:Rabbits; D013455:Sulfur / Q000378:metabolism; D014498:Uracil / Q000031:analogs & derivatives* / Q000378:metabolism
D014498:Uracil; D013455:Sulfur; C012696:acluracil
Identifizierung eines dritten S-haltigen Metaboliten von 1-Allyl-3,5-diethyl-6-chloruracil und Bildungsmechanismus der SCH3-Metaboliten.