[Optimization of the composition of a multicomponent drug form by mathematical investigational designing and experimental testing (author's transl)].
Experiments have been performed to optimize the composition of tablets with 250 mg of noramidopyrine methanesulphonate sodium, 250 mg of aminophenazone and 100 mg of caffeine + sodium benzoate. The effects of the adjuvants Micricell, Aerosil 200, Kollidon CE 5050 and wheat starch on different tablet characteristics (disintegration, mechanical strength, friability and rheological properties) were studied. The results obtained permitted to prepare tablets with good properties: disintegration time, up to 194 s; mechanical strength, greater than 12 kg; friability, less than 0.250%.
D000632:Aminopyrine / Q000008:administration & dosage; D001565:Benzoates / Q000008:administration & dosage; D002110:Caffeine / Q000008:administration & dosage; D004177:Dipyrone / Q000008:administration & dosage / Q000031:analogs & derivatives; D004338:Drug Combinations; D004339:Drug Compounding; D008962:Models, Theoretical; D010592:Pharmaceutic Aids; D047069:Pyrazolones
D001565:Benzoates; D004338:Drug Combinations; D010592:Pharmaceutic Aids; D047069:Pyrazolones; D000632:Aminopyrine; D002110:Caffeine; D004177:Dipyrone; C008667:noramidopyrine
Optimierung der Zusammensetzung einer Mehrkomponenten-Arzneiform durch mathematische Versuchsplanung und experimentelle Prüfung.