Hemorrhagic infarction and coronary reperfusion.
Coronary ligation experiments were performed on 23 primates. Some of the experiments were followed by reperfusion after periods of occlusion of from 1 to 6 hours. Hemorrhage into the infarct was noted in all animals and was greatest following reperfusion after 4 hours of occlusion or longer. Hemorrhage increases the measured infarct size to the point that it is actually larger than that seen with ligation alone. However, this increase is accounted for by the larger amount of intramyocardial hemorrhage. Hemorrhage is greatest in the center of the infarct and decreases at the margins. It appears that hemorrhage occurs into necrotic muscle and does not occur significantly at the margins of the infarct where damage to otherwise viable myocardium might result.
D000818:Animals; D003251:Constriction, Pathologic; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000503:physiopathology; D006470:Hemorrhage / Q000473:pathology* / Q000503:physiopathology; D008251:Macaca; D008954:Models, Biological; D009203:Myocardial Infarction / Q000473:pathology* / Q000503:physiopathology; D009204:Myocardial Revascularization; D013997:Time Factors