Differential effects of clomipramine and clorgyline on the sensitivity of cortical neurons to serotonin: effect of chronic treatment.
The sensitivity of rostral and cingulate cortical neurons to microiontophoretically administered serotonin (5-HT) was compared in groups of rats treated either acutely or chronically with clomipramine (10 mg/kg i.p.) or with clorgyline (0.3 mg/kg i.p.). The sensitivity of cortical neurons to 5-HT was significantly reduced in both cortical areas of animals treated chronically with clorgyline. By contrast, no change of sensitivity was observed in the clomipramine-treated animals. These findings are consistent with biochemical studies showing a decrease in 5-HT receptors following the chronic treatment with clorgyline and an absence of effect on 5-HT receptors following the chronic treatment with clomipramine.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D002997:Clomipramine / Q000494:pharmacology*; D003010:Clorgyline / Q000494:pharmacology*; D004347:Drug Interactions; D007478:Iontophoresis; D008297:Male; D009474:Neurons / Q000187:drug effects*; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*; D013997:Time Factors
D011437:Propylamines; D012701:Serotonin; D003010:Clorgyline; D002997:Clomipramine