The hematopoietic protective effect of bacterial endotoxin prior to nitrogen mustard in the mouse and dog.
Bacterial endotoxin was given to mice 24 h before nitrogen mustard (HN2). Total nucleated cells and peroxidase positive cells/humerus were significantly higher during the recovery phase in endotoxin-treated mice compared to controls given HN2 alone. Endotoxin was also given prior to HN2 in dogs, and a suggestive hematopoietic protective effect was found.
D000818:Animals; D001419:Bacteria; D004285:Dogs; D004731:Endotoxins / Q000494:pharmacology*; D005260:Female; D006413:Hematopoietic System / Q000187:drug effects*; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D009588:Nitrogen Mustard Compounds / Q000633:toxicity*; D010976:Platelet Count
D004731:Endotoxins; D009588:Nitrogen Mustard Compounds