[Certain biochemical and behavioral effects of morphine in rats following amyzil administration].
Motional excitement (ME), dopamine (DA) and homovanillic acid (HVA) content in the caudate nucleus of rats who were injected with morphine in doses of 2 and 10 mg/kg intraperitoneally after amyzil (40 mg/kg) given via the same route were studied to clarify the character of the action of narcotic analgetics on animals' behavior and DAN metabolism under conditions of imbalance between the cholinergic and dopaminergic neuromediator systems of the striatum, induced by central cholinolytics. Amyzil injection was shown to lower HVA level with no changes in DA content (the mediator turnover rate seems to decrease) and to start ME. Under these conditions morphine, in the presence of the induced imbalance of the mediator systems, exhibits a correcting action, elevating HVA level and apparently speeding DA turnover. The biochemical shifts described are accompanied by ME abolition. Possible mechanisms of the action of narcotic analgetics on dopaminergic mediation in the striatum are discussed.
D000818:Animals; D001535:Benactyzine / Q000008:administration & dosage* / Q000494:pharmacology; D002421:Caudate Nucleus / Q000032:analysis*; D004298:Dopamine / Q000032:analysis; D004347:Drug Interactions; D006719:Homovanillic Acid / Q000032:analysis; D008297:Male; D009020:Morphine / Q000008:administration & dosage* / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D001535:Benactyzine; D009020:Morphine; D004298:Dopamine; D006719:Homovanillic Acid
Nekotorye biokhimicheskie i povedencheskie éffekty morfina na fone amizila u krys.