Wegener's granulomatosis and the respiratory system.
Wegener's granulomatosis is a disease characterized by necrotizing vasculitis of the upper and lower respiratory tracts, necrotizing glomerulonephritis, and varying degrees of disseminated small vessel vasculitis. Patients can present to an otolaryngologist head and neck surgeon with ear, nose, throat, lung, orbit, salivary gland, or cutaneous lesions. The disease is variable in its presentation and progression. Tissue biopsies may be non-diagnostic even in the presence of active disease. Although the disease was rapidly fatal as recently at 1970, it can now be effectively treated. This paper reviews the diagnosis and management of Wegener's granulomatosis at a major university hospital between 1965 and 1979. during this period there was a significant evolution of treatment methods.
D000328:Adult; D000368:Aged; D001706:Biopsy; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005921:Glomerulonephritis / Q000150:complications; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007668:Kidney / Q000473:pathology; D008171:Lung Diseases / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010034:Otitis Media with Effusion / Q000150:complications; D010254:Paranasal Sinus Diseases / Q000150:complications; D012220:Rhinitis / Q000150:complications; D013256:Steroids / Q000627:therapeutic use
D013256:Steroids; D003520:Cyclophosphamide