[Experimental hydrocephalus using prolonged angiotensin II application].
In 80 wistar rats were investigated the prolonged action of Angiotensin II in a dosage of 0,05 mg/kg/die ip. appl. on macrostructures of brain. We tested the material 1-, 3-, 7-, 14- and 21 days after the first application. In correlation with duration of the Angiotensin II action a hydroencephalie was produced. This was marked by a lumen, so big as a 1/4-1/5 of the whole brain extent. Further we observed a considerable atrophy of brain structures, particularly in the corpus callosum and the white and gray Substance of cortex. Light-microscopically we would prove edemas perivasculary with separations of ependymal cells. Conceivable mechanisms were discussed.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006849:Hydrocephalus / Q000139:chemically induced*; D008297:Male; D009474:Neurons / Q000187:drug effects; D051381:Rats
D000804:Angiotensin II
Experimentelle Hydroenzephalie durch prolongierte Angiotensin II -- Applikation.