title: Changes in the organization of actin filaments in the stereocilia of noise-damaged lizard cochleae.
abstract: Alligator lizards exposed to 105 dB broadband noise for 24 h showed a 33 dB loss in hearing which was almost completely recovered 11 days after removal from the noise. Two lesions were found in the actin filament organization which could affect the rigidity of the stereocilia and thus could account for this hearing loss. These lesions preferentially affect the tallest stereocilia. The more common one is a depolymerization of the actin filaments at the base of the stereocilium where it makes contact with the cuticular plate. This results in a displacement and detachment of the stereocilium from its rootlet, thereby affecting the orientation of the tallest stereocilium. The other lesion involves a loss in crossbridges between adjacent actin filaments in the stereocilium. We demonstrate that such a loss will dramatically affect the rigidity of the stereocilia.
mesh_terms: D000199:Actins; D000818:Animals; D001309:Auditory Threshold; D003051:Cochlea / Q000648:ultrastructure*; D003599:Cytoskeleton / Q000648:ultrastructure; D006198:Hair Cells, Auditory / Q000648:ultrastructure; D006317:Hearing Loss, Noise-Induced / Q000473:pathology*; D008116:Lizards / Q000033:anatomy & histology*; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning
chemical_list: D000199:Actins