[Accumulation of lipid peroxidation products and suppression of the retinal electrical activity of vitamin E deficient rats exposed to high intensity light].
Induction of alimentary vitamin E deficiency in rats is accompanied by accumulation of lipid peroxidation products in the retina in vivo and by reduction of the magnitude of electroretinogram waves. Photodamage to the retina caused by the action of light of high intensity (10 000 lx for 3.5 h) is more pronounced in vitamin E deficient animals than in control rats fed standard laboratory chow. The exposure of rats to the light of high intensity results in accumulation of lipid peroxides, the magnitude of which is far greater in vitamin E deficient animals than in controls. The photodamage process is reversible and by the end of the 14th day after exposure to light the content of lipid peroxidation products in the retina and its electric activity are close to the values found in controls.
D000818:Animals; D004596:Electroretinography; D008027:Light / Q000009:adverse effects; D008054:Lipid Peroxides / Q000032:analysis*; D008297:Male; D051381:Rats; D012160:Retina / Q000032:analysis / Q000503:physiopathology / Q000528:radiation effects*; D013997:Time Factors; D014811:Vitamin E Deficiency / Q000503:physiopathology*
D008054:Lipid Peroxides
Nakoplenie produktov perekisnogo okisleniia lipidov i podavlenie élektricheskoĭ aktivnosti setchatki E-avitaminoznykh krys pri deĭstvii sveta vysokoĭ intensivnosti.