Anesthetics and the habenulo-interpeduncular system: selective sparing of metabolic activity.
The method of regional localization of brain metabolism by [14C]deoxyglucose during anesthesia in rats shows that pentobarbital, ether and chloral hydrate reduce deoxyglucose uptake in most neuronal regions, with one common exception: spared or increased metabolism is found in the medial habenula, the interpeduncular nucleus, and the habenulo-interpeduncular tract. Prior destruction of afferent inputs abolishes the selective metabolic sparing in the habenulo-interpeduncular system during chloral hydrate anesthesia.
D000818:Animals; D001345:Autoradiography; D001693:Biological Transport, Active / Q000187:drug effects; D002250:Carbon Radioisotopes; D002697:Chloral Hydrate / Q000494:pharmacology*; D003051:Cochlea / Q000187:drug effects / Q000378:metabolism*; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D004986:Ether / Q000494:pharmacology*; D005019:Ethyl Ethers / Q000494:pharmacology*; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000378:metabolism*; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats
D002250:Carbon Radioisotopes; D003837:Deoxy Sugars; D005019:Ethyl Ethers; D004986:Ether; D002697:Chloral Hydrate; D003847:Deoxyglucose; D010424:Pentobarbital