The treatment of osteomyelitis of the tibia with sodium salicylate. An experimental study in rabbits.
Osteomyelitis was induced in the tibiae of rabbits by injecting a suspension of Staphylococcus aureus and sodium tetradecylsulphate, a sclerosing agent. These rabbits were then divided into two groups: one group remained untreated and the other was fed a diet containing sodium salicylate. Two and four weeks after induction of osteomyelitis the tibiae taken from untreated rabbits with osteomyelitis and incubated in vitro released significantly more prostaglandin E and F than the control uninjected or uninfected tibiae. Tibiae taken from rabbits treated with sodium salicylate showed minimal radiographic changes and a significantly decreased release of prostaglandin E and F compared to the untreated rabbits. Prostaglandins are known to be potent bone resorbing agents and the results of this study suggest that they may also be involved in the destruction of bone which is characteristic of osteomyelitis. The treatment of rabbits with osteomyelitis using anti-inflammatory drugs, which block synthesis of prostaglandins, in addition to antibiotics, may prevent the destruction of bone and possible sequestration thereby decreasing the risk of chronic disease.
D000818:Animals; D001862:Bone Resorption / Q000187:drug effects; D010019:Osteomyelitis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D011458:Prostaglandins E / Q000037:antagonists & inhibitors; D011460:Prostaglandins F / Q000037:antagonists & inhibitors; D011817:Rabbits; D011859:Radiography; D012459:Salicylates / Q000378:metabolism / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology
D011458:Prostaglandins E; D011460:Prostaglandins F; D012459:Salicylates