Potentiation of the inhibition of rat liver monoamine oxidase-a by clorgyline after pretreatment with SKF 525A.
Pretreatment of rat liver homogenates with 1.5 x 10(-4) M SKF 525A is without effect on the activity of monoamine oxidase-A, but results in a decrease in the concentration of clorgyline required for the inhibition of this enzyme form. Such a result is consistent with the hypothesis that rat liver homogenates contain an SKF 525A-sensitive clorgyline-metabolising system.
D000818:Animals; D003010:Clorgyline / Q000494:pharmacology*; D004357:Drug Synergism; D008099:Liver / Q000201:enzymology*; D008995:Monoamine Oxidase / Q000494:pharmacology*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D011335:Proadifen / Q000494:pharmacology*; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats
D008996:Monoamine Oxidase Inhibitors; D011437:Propylamines; D011335:Proadifen; D008995:Monoamine Oxidase; D003010:Clorgyline