title: [Studies of sulfhemoglobin formation by various drugs (4). Influences of various antidotes on chemically induced methemoglobinemia and sulfhemoglobinemia (author's transl)].
abstract: The influences of methylene blue (MB), thionine, ascorbic acid (ASA), sodium thiosulfate (STS), N-(2-mercaptopropionyl)-glycine (MPG) and reduced glutathione (GSH) on methemoglobin-(MHb)-emia and sulf-hemoglobin (SHb)-emia induced by 4-chloroaniline (4-Cl-A) i.p. were studied. Preventive or therapeutic effect on MHb-emia and preventive effect on SHb-emia in mice: MHb formation was inhibited by MB i.p. whether it was administered simultaneously with or after 4-Cl-A, but SHb formation was increased. Similar effects were seen with thionine. Both compounds proved to have MHb and SHb forming activities. STS or MPG, if administered i.p. simultaneously with 4-Cl-A, inhibited formation of MHb, but exerted no effect on delayed SHb formation. However, if administered i.p. or i.v. 120 minutes after 4-Cl-A when the peak of MHb formation had passed, there was a preventive effect on delayed SHb formation. GSH inhibited MHb formation and prevented SHb formation only when it was administered i.v. 120 minutes after 4-Cl-A. ASA did not inhibit MHb formation when it was administered either i.p. or i.v., but showed a preventive effect on SHb formation, if administered 120 minutes after 4-Cl-A. Combined i.v. administration of the corresponding doses to the clinical ones of MB and ASA 120 minutes after 4-Cl-A showed a therapeutic effect on MHb-emia and a preventive effect on SHb-emia. However, at higher dose levels, MB masked the preventive effect of ASA on SHb-emia. Therapeutic effect on SHb-emia in mice and rats: None of MB, STS, GSH and ASA proved to have any therapeutic effects for established SHb-emia. On the basis of these results, significance of clinical usage of drugs in the treatment of chemically induced MHb-emia and SHb-emia is discussed.
mesh_terms: D000814:Aniline Compounds; D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use; D004880:Ergothioneine / Q000627:therapeutic use; D005978:Glutathione / Q000627:therapeutic use; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D008751:Methylene Blue / Q000627:therapeutic use; D051379:Mice; D051381:Rats; D013436:Sulfhemoglobinemia / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D013885:Thiosulfates; D008625:Tiopronin / Q000627:therapeutic use
chemical_list: D000814:Aniline Compounds; D013885:Thiosulfates; D004880:Ergothioneine; D008625:Tiopronin; D005978:Glutathione; C017717:sodium thiosulfate; D001205:Ascorbic Acid; D008751:Methylene Blue; C004658:4-chloroaniline