Anesthetic, hypothermic, myorelaxant and anticonvulsant effects of synthetic eugenol derivatives and natural analogues.
Nine newly synthesized eugenol derivatives were investigated in rats or mice as to their anesthetic, hypothermic, myorelaxant and anticonvulsant effects. Additional pharmacological activity which appeared during the experiments is described. For comparative purposes, six naturally occurring eugenol analogues were included in the study. The results are further discussed as to possible structure-activity relationships between the test compounds and the four investigated effects.
D000777:Anesthetics; D000818:Animals; D000927:Anticonvulsants; D001831:Body Temperature / Q000187:drug effects; D004597:Electroshock; D005054:Eugenol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D009125:Muscle Relaxants, Central; D051381:Rats
D000777:Anesthetics; D000927:Anticonvulsants; D009125:Muscle Relaxants, Central; D005054:Eugenol