Low-dose topical atropine for rhinorrhea.
One hundred years ago, atropine sulfate was commonly used to treat rhinorrhea. Atropine sulfate was applied topically at a dose of approximately 0.08 mg to each nostril in seven patients with rhinorrhea caused by allergic rhinitis and in 24 patients with rhinorrhea caused by viral rhinitis. All but one of the 31 patients had symptomatic relief. Twenty-four of the 31 patients showed a visible decrease in secretions, and three patients showed an obvious vasoconstriction of nasal blood vessels. None of the patients experienced any of the side effects of atropine. Since this was a one-dose pilot study, there are no data available on possible rebound or chemical rhinitis effects.
D000287:Administration, Topical; D001285:Atropine / Q000008:administration & dosage*; D006801:Humans; D010865:Pilot Projects; D012220:Rhinitis / Q000188:drug therapy*; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*; D014777:Virus Diseases / Q000188:drug therapy*
D001285:Atropine