Elastin metabolism in rodent lung.
Data from the in vivo incorporation of [3H]valine into fractions of elastin obtained from rat or mouse lung suggest that postnatal lung elastin synthesis occurs predominantly in the first 1 to 2 weeks of life. Very little [3H]valine was incorporated into lung elastin obtained from adult animals. When lung elastin from neonatal mice was radiochemically labelled with [14C]lysine as a single pulse, it was observed that the specific activity of the elastin expressed as the total dpm values as 14C per mg was not significantly altered over a 6 month period. Elastin appears to turn over very slowly in mouse lung with half-life best estimated in years.
D000818:Animals; D000831:Animals, Newborn; D004549:Elastin / Q000096:biosynthesis / Q000378:metabolism*; D006207:Half-Life; D008168:Lung / Q000254:growth & development / Q000378:metabolism*; D051379:Mice; D051381:Rats; D014633:Valine / Q000378:metabolism
D004549:Elastin; D014633:Valine