[The influence of the polymorphism of the active substance on the properties of tablets. Part 3. Compressional behaviour of meprobamate (author's transl)].
Three polymorphic meprobamate-modifications (I, II, III) of different particle size were compressed without other ingredients on a hydraulic press under 30, 60, 120, and 240 N/mm2. The rather soft substance shows a high degree of densification and above ca. 60 N/mm2 also good consolidation properties. The void volumes of the compacts obey the equation of Kawakita and are increasing in all cases in the sequence I leads to III leads to II. The radial breaking strength generally decreases in the same succession and depends linearly on the logarithm of compaction pressure. It is noteworthy, that the modification with the highest density (I) has the highest plasticity and is also compacted most easily. Modification II which is slightly harder and has a density between modifications I and III, shows the greatest differences in the compaction behaviour, as compared to modification I. Its breaking strength is also increasing faster with compaction pressure than the other modifications.
D004339:Drug Compounding; D006245:Hardness Tests; D008620:Meprobamate / Q000008:administration & dosage*; D010316:Particle Size; D011312:Pressure; D013607:Tablets; D013816:Thermodynamics
D013607:Tablets; D008620:Meprobamate
Einfluss der Polymorphie des Wirkstoffes auf die Eigenschaften von Tabletten. 3. Mitteilung: Kompressionsverhalten von Meprobamat.