title: Changes in the free and rough endoplasmic reticulum-bound ribosomes of Ehrlich ascites cancer cells during the cell cycle.
abstract: The amount of rough endoplasmic reticulum (RER) and associated polyribosomes changes during the cell cycle. We describe here the amount and activity of free and RER-bound ribosomes of Ehrlich ascites cancer cells. RER does not exist during the G1, G2 and M phases, it appears in the early S phase and decreases in the second half of S. The formation of RER during the S phase and the S phase RER-found ribosomes may be related to the biosynthesis of histones, some fundamental non-histonic nuclear proteins, and enzymes involved in DNA replication and several metabolic reactions.
mesh_terms: D000818:Animals; D001345:Autoradiography; D002286:Carcinoma, Ehrlich Tumor / Q000648:ultrastructure*; D002453:Cell Cycle; D004721:Endoplasmic Reticulum / Q000648:ultrastructure*; D007399:Interphase; D051379:Mice; D008854:Microscopy, Electron; D011132:Polyribosomes / Q000648:ultrastructure; D012270:Ribosomes / Q000648:ultrastructure*