[Nature of the relation between the anticonvulsant action of phenazepam and its concentration in mouse brain].
A method has been suggested for simultaneous recording of the content of 12C-phenazepam and its metabolites in the mouse brain and of minimum effective doses of corasole intravenously that induce the tonic extension of the animals. Parameters of the two-compartmental kinetic model of absorption, distribution and elimination of 14C-products in the mouse brain were determined. These processes conform to the first order kinetics. A correlation was disclosed between the content of radioactive products in the animals' brain and minimum effective doses of corasole. A linear decline of the anticonvulsant action of phenazepam was revealed during the experimental period. Radiochromatography enabled one to detect the parent compound and its 3-hydroxy metabolite in mouse brain extracts.
D000818:Animals; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants / Q000032:analysis*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000032:analysis* / Q000627:therapeutic use; D001923:Brain Chemistry; D005260:Female; D006824:Hybridization, Genetic; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors*; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; D010433:Pentylenetetrazole
Kharakter vzaimosviazi mezhdu protivosudorozhnym deĭstviem fenazepama i ego soderzhaniem v golovnom mozge mysheĭ.