title: Optimized mitochondrial function as a nutritional strategy in cancer immunotherapy.
abstract: Activated macrophages require effective mitochondrial function, but mitochondrial efficiency is jeopardized by the free radicals produced naturally in macrophage metabolism. This perspective rationalizes the well-documented immunostimulant effects of coenzyme Q and of antioxidant nutrients such as selenium, vitamin E, and manganese. More generally, the nutritional optimization of mitochondrial function is proposed as a "neo-Warburgian' approach to cancer immunotherapy.
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use; D005609:Free Radicals; D007167:Immunotherapy; D008264:Macrophages / Q000502:physiology*; D008928:Mitochondria / Q000502:physiology*; D009369:Neoplasms / Q000628:therapy*; D010084:Oxidation-Reduction
chemical_list: D000975:Antioxidants; D005609:Free Radicals