Kinetics of self-sensitized and riboflavin-sensitized photodegradation of bilirubin.
Kinetics of self-sensitized or riboflavin-sensitized photodestruction of bilirubin in albumin containing solutions follows equations of the Stern-Volmer type, which resemble expressions of enzyme catalyzed reactions. The dependence of quantum yields of bilirubin decay on substrate concentration, bilirubin/albumin ratio, and riboflavin concentration is estimated and described in terms of such equations. The ratios of kinetic constants obtained in this way are discussed and related to clinical experiences regarding the phototherapy for the treatment of neonatal hyperbilirubinaemia.
D001663:Bilirubin / Q000378:metabolism*; D006801:Humans; D008027:Light; D008956:Models, Chemical; D010084:Oxidation-Reduction; D012256:Riboflavin / Q000494:pharmacology*; D012709:Serum Albumin / Q000378:metabolism
D012709:Serum Albumin; D001663:Bilirubin; D012256:Riboflavin