[Effects of prostaglandin E1 analogue and prostaglandin F2 alpha on uterine contraction, uterine blood flow and fetal circulation in pregnant and nonpregnant rabbits (author's transl)].
Effects of PGF2 alpha and PGE1 analogue (ONO-802) on uterine contraction, uterine blood flow and fetal circulation were studied in pregnant and mature nonpregnant rabbits. Uterine and fetal blood flows were measured by photoplethysmography. Ten ng of PGs were injected into aorta abdominalis. In pregnant rabbits, 10 ng of PGF2 alpha caused a great increase in uterine contraction (i.e., intrauterine pressure), slight decrease in uterine blood flow and a transient fetal bradycardia, while 10 ng of ONO-802 caused a slight increase in uterine contraction (i.e., frequency), moderate decrease in uterine blood flow and a transient fetal bradycardia. Responses in nonpregnant rabbits to these two PGs were almost the same as those in pregnant rabbits. These results indicate the different effects of these two PGs on the uterine blood flow.
D000818:Animals; D005260:Female; D005333:Fetus / Q000502:physiology*; D011247:Pregnancy; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D011817:Rabbits; D012039:Regional Blood Flow; D014590:Uterine Contraction / Q000187:drug effects*; D014599:Uterus / Q000098:blood supply*
D011459:Prostaglandins E, Synthetic; D011460:Prostaglandins F