Inhibition of metabolic cooperation in Chinese hamster cells by various chemical including tumor promoters.
The effects of 12-O-tetradecanoyl phorbol-13-acetate (TPA) and other chemicals on the contact-feeding phenomenon were investigated. The death of 6-TGr cells was prevented by TPA even upon culture with 3 times as many wild-type cells as in TPA-free medium. Seven out of 18 chemicals tested were shown to inhibit the phenomenon of metabolic cooperation. They were concanavalin A, lithocholic acid, chaetoglobosin A, 3-hydroxyanthranilic acid, urea, anthralin and saccharin. Among known tumor promoters, sodium deoxycholate, estradiol and phenobarbital did not inhibit the phenomenon of metabolic cooperation.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002462:Cell Membrane / Q000187:drug effects; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D010704:Phorbols / Q000633:toxicity*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*; D013866:Thioguanine / Q000494:pharmacology
D002273:Carcinogens; D010704:Phorbols; D013866:Thioguanine; D013755:Tetradecanoylphorbol Acetate