title: [Effect of discontinuation of long-term preventive lithium therapy].
abstract: The development of manic-depressive psychoses (15 cases) and attack-like schizophrenia (20 cases) was studied, following a withdrawal of a durable and successful prophylactic intake of lithium preparations. A comparison with a control group selected according to the double method, not suspending the administration of lithium salts, demonstrated a statistically significant increase of phases-attacks, their aggravation as well as an increased amount of hospitalizations due to lithium withdrawal. The conclusion is made that there is a necessity for durable and continuous lithium prophylaxis even after obtaining complete remissions.
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008094:Lithium / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D012075:Remission, Spontaneous; D012559:Schizophrenia / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D008094:Lithium
vernacular_title: Effekt otmeny dlitel'noĭ profilakticheskoĭ litievoĭ terapii.