Ibuprofen induced hyponatraemia.
A 55-year-old woman in an advanced stage of chronic renal failure due to pyelonephritis developed severe hyponatraemia after receiving 400 mg/day of ibuprofen for 3 days. The typical symptoms and the hyponatraemia disappeared when the drug was withdrawn. The likely mechanism involved and the clinical implications are discussed.
D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced*; D007052:Ibuprofen / Q000009:adverse effects*; D008875:Middle Aged; D011704:Pyelonephritis / Q000188:drug therapy; D014869:Water Intoxication / Q000209:etiology
D007052:Ibuprofen