Effects of pimozide on accuracy of performance and distribution of correct responding on a simultaneous discrimination task in the rat.
After training rats in a simultaneous discrimination problem, pimozide, a dopamine receptor blocker, was administered to determine whether accuracy of performance would be disrupted. Each animal received five doses of pimozide (vehicle, 0.05, 0.10, 0.30, and 0.60 mg/kg) delivered in a Latin Square sequence with five non-drug days between injections. Pimozide did not disrupt well established discrimination behavior at any of the doses even though a decrease in rate of responding was observed at the two higher doses. These results provide additional evidence that DA neutrons are not essential in the mediation of previously learned associations.
D000818:Animals; D004193:Discrimination Learning / Q000187:drug effects*; D008297:Male; D010868:Pimozide / Q000494:pharmacology*; D051381:Rats
D010868:Pimozide