Developmental study of rat brain glutathione peroxidase and glutathione reductase.
Glutathione peroxidase and glutathione reductase activities were measured in whole rat brains at selected ages from birth to adulthood. On a wet weight basis glutathione peroxidase activity increased 70% during development and glutathione reductase activity increased 160%. On a protein basis glutathione peroxidase declined slightly in activity during the first two weeks of life and then maintained the 14-day activity into adulthood while glutathione reductase showed a 30% increase in activity. While less than the developmental changes in many enzyme involved in aerobic glycolysis or catecholamine metabolism, these increases do suggest a role in CNS metabolism.
D000375:Aging; D000818:Animals; D001921:Brain / Q000201:enzymology*; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism*; D008297:Male; D010544:Peroxidases / Q000378:metabolism*; D051381:Rats
D010544:Peroxidases; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione