title: The production of malignant tumors of the lung and pleura in dogs from intratracheal asbestos instillation and cigarette smoking.
abstract: Nine dogs were given early intratracheal instillations of crocidolite asbestos for periods up to three years. The maximum dose totalled 66 mg/kg. In addition, seven of these dogs smoked nine cigarettes per day, five days per week for six years. A malignant pleural and/or peritoneal mesothelioma developed in six of these dogs, and adenocarcinoma of the lung developed in four, one of which had areas of squamous differentiation. The first animal died of a malignant tumor six years after the onset of exposure, and the last animal died eight years after the onset.
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000473:pathology; D000818:Animals; D001194:Asbestos; D004285:Dogs; D008175:Lung Neoplasms / Q000209:etiology*; D008297:Male; D008654:Mesothelioma / Q000209:etiology / Q000473:pathology; D009374:Neoplasms, Experimental / Q000209:etiology / Q000473:pathology; D010997:Pleural Neoplasms / Q000209:etiology* / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000209:etiology / Q000473:pathology; D012907:Smoking; D013997:Time Factors
chemical_list: D001194:Asbestos