Production of blood capillary contracting substance after administration of estrogen to rabbit.
Estradiol was continuously injected to female rabbits with a daily dose of 10,000 units for 50 days, and androgen was similarly given to male rabbits. Samples were obtained from livers of these rabbits according to the method of "placental capillary contracting substance", and their capillary contracting activities were determined. A substance showing a high activity was obtained from the liver of the rabbit treated with estradiol. A capillary contracting substance was also extracted from the urine of pregnant women, but it was hardly obtained from the urine of normal men.
D000728:Androgens / Q000494:pharmacology; D000818:Animals; D002196:Capillaries / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008099:Liver / Q000032:analysis; D008297:Male; D009132:Muscles / Q000032:analysis; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011817:Rabbits; D014662:Vasoconstrictor Agents / Q000096:biosynthesis* / Q000302:isolation & purification
D000728:Androgens; D014662:Vasoconstrictor Agents; D004958:Estradiol