[Treatment of orthostatic hypotension induced by tricyclic antidepressants with yohimbine (author's transl)].
Following the observation that two patients with depression and essential orthostatic hypotension recovered from the latter affection after yohimbine administration, an open study was conducted to assess the activity of yohimbine in correcting orthostatic hypotension induced by tricyclic antidepressants. Results were conclusive in 10 of the 11 patients treated, and were confirmed in a further 12 cases during a double-blind study. Yohimbine appears to be the most effective treatment for orthostatic hypotension, either essential or induced by thymoanaleptic or neuroleptic therapy.
D001794:Blood Pressure / Q000187:drug effects; D002997:Clomipramine / Q000009:adverse effects*; D003863:Depression / Q000188:drug therapy; D004311:Double-Blind Method; D006801:Humans; D007024:Hypotension, Orthostatic / Q000139:chemically induced / Q000188:drug therapy*; D015016:Yohimbine / Q000627:therapeutic use*
D015016:Yohimbine; D002997:Clomipramine
Effets coarrecteurs de la yohimbine sur l'hypotension orthostatique induite par les antidépresseurs tricycliques.