Intraventricular neuroblastoma in a patient wit von Hippel-Lindau's disease. Light and electron microscopic study.
Cerebral neuroblastoma is a rare neoplasm that has not previously been associated with a phakomatosis. We report a case of an intraventricular neuroblastoma in a patient with Von Hippel-Lindau's disease. The neoplasm consisted of process-forming cells containing clear vesicles, dense-cored granules and microtubules. An unusual finding was the presence of intertwining cytoplasmic processes, apparently representing aberrant process formation. We suggest that this case represents a cerebral neuroblastoma occurring as an unusual manifestation of a phakomatosis.
D000328:Adult; D000798:Angiomatosis / Q000473:pathology*; D002551:Cerebral Ventricle Neoplasms / Q000150:complications / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009447:Neuroblastoma / Q000150:complications / Q000473:pathology* / Q000648:ultrastructure; D006623:von Hippel-Lindau Disease / Q000150:complications / Q000473:pathology*