title: [Synthesis of 4-ureidooxycyclophosphamide (author's transl)].
abstract: The synthesis of 4-ureidooxycyclophosphamide, a potential cytostatic, whose cis/trans-isomers can be stereoselectively obtained from 4-hydroxycyclophosphamide and hydroxyurea in DMF in DMF or water, is described. These compounds are remarkably stable at room temperature. For the first time, the two epimers from a derivative of 4-hydroxycyclophosphamide can be NMR-spectroscopically compared with each other.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D003520:Cyclophosphamide / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D009682:Magnetic Resonance Spectroscopy; D013237:Stereoisomerism
chemical_list: C035012:4-ureidooxycyclophosphamide; D003520:Cyclophosphamide
vernacular_title: Synthese von 4-Ureidooxycyclophosphamid.