Clonidine-induced lipolysis in dog adipocytes by stimulation of histamine (H2)-receptors.
The effect of the alpha-adrenergic agonist clonidine on lipolysis was investigated in omental dog fat cells. In presence of theophylline, clonidine markedly enhanced lipolysis. This effect was competitively inhibited by the (H2)-receptor blocking agent cimetidine while the H1-histamine receptor antagonist (mepyramine) was without any significant effect. This result suggests that clonidine stimulates dog adipocyte lipolysis through histamine (H2)-receptor activation. Histamine and clonidine stimulated dog fat cell adenylate cyclase; the stimulation was suppressed by cimetidine.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000273:Adipose Tissue / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D004285:Dogs; D006632:Histamine / Q000494:pharmacology; D008066:Lipolysis / Q000187:drug effects*; D011738:Pyrilamine / Q000494:pharmacology; D011968:Receptors, Histamine / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects*; D013268:Stimulation, Chemical; D013806:Theophylline / Q000494:pharmacology
D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D006632:Histamine; D013806:Theophylline; D000262:Adenylyl Cyclases; D011738:Pyrilamine; D003000:Clonidine