High dose estrogen response of the hormone independent R3327-At Copenhagen rat prostatic tumor.
In studies with the hormone independent R3327-At prostatic tumor, relatively high doses of estrogen were inhibitory to the growth of the R3327-At rat prostatic tumor were observed. It was further observed that although tumor growth was inhibited, an increase in the [3H]thymidine labelling of the DNA of the tumor cells of the estrogen treated group relative to the castrate control was apparent.
D000818:Animals; D004054:Diethylstilbestrol / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains; D013629:Tamoxifen / Q000494:pharmacology
D013629:Tamoxifen; D004958:Estradiol; D004054:Diethylstilbestrol