Scale prophylaxis. A new antiparakeratotic assay.
This article describes a new animal model for the evaluation of drugs that may prevent the development of parakeratosis. The advantages of this model are simplicity, economy, and the opportunity to observe the possible occurrence of acute systemic toxic reactions. High-boiling coal tar acids (phenols), vitamin A (retinyl acetate), and hydrocortisone butyrate (Locoid) were assayed. Only tar phenols consistently prevented scale development. Vitamin A was not properly screened because of toxic effects that resulted in premature termination of the experiment.
D000818:Animals; D000831:Animals, Newborn; D003033:Coal Tar / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006854:Hydrocortisone / Q000627:therapeutic use; D007641:Keratolytic Agents / Q000627:therapeutic use*; D007642:Keratosis / Q000517:prevention & control*; D051379:Mice; D010241:Parakeratosis / Q000517:prevention & control*; D014801:Vitamin A / Q000627:therapeutic use
D003879:Dermatologic Agents; D007641:Keratolytic Agents; D014801:Vitamin A; D003033:Coal Tar; D006854:Hydrocortisone