Long-term follow-up of incorporation of 15N from glycine into uric acid in gout.
The incorporation of 15N-glycine into urinary uric acid was studied in three gouty patients, repeating a study carried out 13 to 27 years ago. The 15N incorporation attained a lower maximum and declined less rapidly in the repeat study in all three patients. The cumulative 15N incorporation into uric acid was reduced to one half of that determined previously. Similarly, urinary uric acid excretion was less, along with a lower uric acid nitrogen to total nitrogen ratio. The data indicate changes in the nature of the metabolic aberrations, which are apparently related to long-term drug therapy, changes in lifestyle, aging and associated medical complications.
D000328:Adult; D000368:Aged; D000375:Aging; D005500:Follow-Up Studies; D005998:Glycine / Q000008:administration & dosage / Q000378:metabolism*; D006073:Gout / Q000188:drug therapy / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000378:metabolism*; D009587:Nitrogen Isotopes; D013997:Time Factors; D014527:Uric Acid / Q000652:urine*
D009587:Nitrogen Isotopes; D014527:Uric Acid; D009584:Nitrogen; D005998:Glycine