Studies on cholesterol ester hydrolysis in artificial lipid mixtures.
Cholesterol ester is present in lipid deposits in atherosclerotic lesions, such as fatty streaks, fibrous plaques and complicated lesions. The possibility of hydrolysis of cholesterol ester in lipid deposits and its mechanism were examined by studying the effects of the various components of lipid deposits on cholesterol ester hydrolysis. Studies were carried out using artificial lipid samples prepared by sonication of mixtures of the components of lipid deposits. Results suggested that phospholipids, especially phosphatidylcholine, play an important role in the hydrolysis and that alteration of lipid components, other than cholesterol ester, influences cholesterol ester hydrolysis in lipid deposits.
D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism; D002788:Cholesterol Esters / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007185:Incubators; D050356:Lipid Metabolism; D008297:Male; D010713:Phosphatidylcholines / Q000494:pharmacology; D010714:Phosphatidylethanolamines / Q000494:pharmacology; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D002788:Cholesterol Esters; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids