Determination of oxalic acid clearance and plasma concentration by radioisotope infusion. Results in a family with hyperoxaluria.
The renal clearance of 14C-oxalate was studied in a family with two children suffering from primary hyperoxaluria. The 14C-oxalate/creatinine clearance ratio ranged from 1.8 to 2.6 (mean 2.0) and appeared to be independent of the glomerular filtration rate. The calculated plasma oxalate concentrations in the three normo-oxaluric subjects ranged from 0.1 to 0.9 mumol/l, whereas values of 3.2 and 16.3 mumul/l were found in the two hyperoxaluric subjects. In the latter patient, the oxalate production decreased and the clearance increased after vitamin B6 treatment, resulting in a drop in the oxalate plasma level to 5.3 mumol/l. The apparent distribution volumes, expressed as percentage of body weight, ranged from 30 to 47% (mean 35). The mean biological half-life of 14C-oxalate was 2.7 hours in the subjects with normal renal function and increased with impairment of renal function. The recovery of 14C in the urine ranged from 87 to 112% (mean 101); all 14C activity was recovered as oxalate.
D000293:Adolescent; D002250:Carbon Radioisotopes; D002648:Child; D005260:Female; D006207:Half-Life; D006801:Humans; D007223:Infant; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008661:Metabolism, Inborn Errors / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D010070:Oxalates / Q000378:metabolism*; D011736:Pyridoxine / Q000627:therapeutic use
D002250:Carbon Radioisotopes; D010070:Oxalates; D011736:Pyridoxine