title: Results of oophorectomy by menstrual and estrogen receptor states in patients with metastatic breast cancer.
abstract: The records of 204 women with metastatic breast carcinoma treated by oophorectomy were analyzed. Premenopausal women had a response rate of 50 percent. Forty-one percent of postmenopausal women responded. Those who responded had an average duration of response of 22 months and a length of survival twice that of the nonresponders. There was a better than 60 percent correlation between response to oophorectomy and response to further endocrine ablation. Response to endocrine manipulation is more a function of the hormonal sensitivity of the carcinoma than of menopausal status.
mesh_terms: D001943:Breast Neoplasms / Q000503:physiopathology / Q000556:secondary / Q000628:therapy*; D002369:Castration; D005260:Female; D006801:Humans; D008593:Menopause; D008598:Menstruation; D011960:Receptors, Estrogen / Q000502:physiology*
chemical_list: D011960:Receptors, Estrogen