[Morphology of the pig liver after Fluosol infusion].
About 500 ml of blood of young pigs weighing 20...25 mg were replaced by artificial blood substitute "Fluosol-DA 20%". Eight days after exchange the animals were sacrificed and the liver was fixed for electron microscopic investigation. The morphological studies showed Fluosol-droplets in the cytoplasma of parenchymal cells near the bile canaliculi and in the sinusoidal lining cells. Most Fluosol-droplets were found in the endothelial and Kupffer cells which both seemed to be completely filled. The ballooning of these cells often resulted in a partial occlusion of the sinusoids. The sinusoidal lining cells were saturated by Fluosol droplets to such an extent that they seemed to be unable to phagocytize further.
D000818:Animals; D001802:Blood Substitutes / Q000032:analysis / Q000494:pharmacology*; D003593:Cytoplasm / Q000032:analysis; D004338:Drug Combinations / Q000494:pharmacology; D004727:Endothelium / Q000648:ultrastructure; D005466:Fluorocarbons / Q000494:pharmacology*; D006895:Hydroxyethyl Starch Derivatives; D007728:Kupffer Cells / Q000648:ultrastructure; D008099:Liver / Q000032:analysis / Q000648:ultrastructure*; D010587:Phagocytosis
D001802:Blood Substitutes; D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination
Morphologische Befunde an der Schweineleber nach Fluosol-Infusion.