[18,19,20-trinor-17-cyclohexyl-13,14-dehydro PGF 2 alpha methylester as the cause of hypertension in pulmonary circulation].
The hemodynamic effects of a synthetic compound of PGF 2 alpha have been studied before and after vagosympathectomy. Synthetic PGF 2 alpha caused a marked hypertension in the pulmonary circulation linked with the vasoconstrictor action of this substance on the small lung vessels. A slight hypotension was observed in the denervated animal where the highest values of pulmonary pressure were reached. The authors conclude that this fact may be due to an inhibition of the vasoconstrictor systemic tone secondary to the pulmonary hypertensive state.
D000818:Animals; D015237:Dinoprost / Q000031:analogs & derivatives*; D005260:Female; D006973:Hypertension / Q000139:chemically induced*; D008297:Male; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D011652:Pulmonary Circulation / Q000187:drug effects*; D013552:Swine; D013562:Sympathectomy; D014628:Vagotomy
D011461:Prostaglandins F, Synthetic; C029284:18,19,20-trinor-17-cyclohexyl-13,14-dehydroprostaglandin F2alpha methyl ester; D015237:Dinoprost
Il 18,19,20-trinor-17-cicloesil-13,14-deidro PGF 2 alfa metilestere quale causa di ipertensione nel circolo polmonare.