title: [Platinum derivatives in the clinical chemotherapy of malignant tumors].
abstract: Perspectives in clinical chemotherapy with a newly-developed class of compounds - complex derivatives of platinum-are discussed. The history of their development, mechanism of action as well as pharmacokinetics and side-effects of cis-diamminodichloroplatinum are presented. The efficacy of cis-platinum treatment of malignant tumors of the testicle, ovarian and breast carcinoma and other tumors is evaluated on the basis of the literature data and clinical findings of the research staff of the Center.
mesh_terms: D002945:Cisplatin / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D002945:Cisplatin
vernacular_title: Proizvodnye platiny v klinicheskoĭ khimioterapii zlokachestvennykh opukholeĭ.