Effect of L-fucose on brain protein metabolism and retention of a learned behavior in rats.
The intraperitoneal or intraventricular application of L-fucose (100 mg/kg or 75 microgram, respectively) prior to training in shuttle box avoidance as well as in shock-motivated brightness discrimination in rats significantly improved the retention of learned behavior 24 hr later. The application of D-fucose was without influence on retention. In naive animals, intraventricularly applied L-fucose (75-200 microgram) caused an increase in the rate of protein synthesis in the hippocampus, resulting in a significant increase in total proteins of this brain structure, mainly attributed to the Tris-insoluble protein fractions. The results are discussed in terms of an activation of glycoprotein formation by increasing supply with L-fucose.
D000818:Animals; D004192:Discrimination, Psychological; D005643:Fucose / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000378:metabolism*; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism*; D051381:Rats
D009419:Nerve Tissue Proteins; D011506:Proteins; D005643:Fucose