Effect of nicotinic acid on the concentration of cerebroside in rat brain.
The effect of nicotinic acid on the changes of rat brain cerebroside levels has been studied during brain development. There is a gradual increase in the concentration of cerebroside from 12 days of age to adult level at approximately 47 days of age. However, the concentration of cerebroside was significantly lower in brain of rat fed the nicotinic acid-deficient diet. Therefore, nicotinic acid may play an important role in cerebroside synthesis in brain of developing rat.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D002554:Cerebrosides / Q000032:analysis*; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000032:analysis; D009539:Nicotinic Acids / Q000032:analysis / Q000172:deficiency / Q000494:pharmacology*; D051381:Rats
D002554:Cerebrosides; D008055:Lipids; D009539:Nicotinic Acids