alpha-Flupenthixol increases slow-wave in rats: effect of dopamine receptor blockade.
alpha-Flupenthixol (0.2 mg/kg, i.p.), a dopamine receptor blocker, significantly increased slow-wave sleep and decreased wakefulness in rats when administered either at the onset of a 12-hr light period or a 12-hr dark period. The same dose of the drug strongly antagonized the dopamine-mediated stereotype produced by an injection of apomorphine (1 mg/kg, i.p.) for at least 9-hr, indicating that dopamine receptors were blocked throughout most of the recording session. The results suggest a relationship between the blockade of dopamine receptors and the increase of slow-wave sleep time.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005475:Flupenthixol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D012894:Sleep Stages / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects; D013892:Thioxanthenes / Q000494:pharmacology*; D014851:Wakefulness / Q000187:drug effects
D011954:Receptors, Dopamine; D013892:Thioxanthenes; D005475:Flupenthixol; D001058:Apomorphine