The effects of strychnine and bicuculline on the responses of X- and Y-cells of the isolated eye-cut preparation of the cat.
The effects of strychnine and bicuculline, the respective antagonists of glycine and GABA, on the inhibitory responses of X- and Y-type retinal ganglion cells of the cat were investigated using an isolated eye-cup preparation. The surround inhibition of the on-center X-cell was blocked by strychnine, whereas that of the on-center Y-cell was blocked by bicuculline. In the case of the off-center cells, bicuculline indifferently blocked the center and the surround responses of either the X-cell or the Y-cell, but strychnine did not.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D002415:Cats; D005071:Evoked Potentials / Q000187:drug effects; D018756:GABA Antagonists; D005998:Glycine / Q000037:antagonists & inhibitors; D009433:Neural Inhibition / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D010775:Photic Stimulation; D012160:Retina / Q000166:cytology / Q000187:drug effects*; D013331:Strychnine / Q000494:pharmacology*
D018756:GABA Antagonists; D013331:Strychnine; D005998:Glycine; D001640:Bicuculline