Synergistic effects of probucol and cholestyramine to lower serum cholesterol.
Ten men with hypercholesterolemia were treated sequentially with a fat-modified diet, a diet plus probucol (1 Gm/day), and a diet plus probucol plus cholestyramine (16 Gm/day). Each treatment period was 12 weeks. Diet alone reduced mean serum cholesterol by 1.0 per cent. Diet plus probucol caused a mean 7.7 per cent reduction in serum cholesterol below the baseline values (P = 0.001 compared to diet). Adding cholestyramine to probucol and diet resulted in a mean 18.2 per cent reduction in serum cholesterol below baseline values (P = 0.001 compared to probucol and diet). The treatment was well tolerated.
D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood; D002792:Cholestyramine Resin / Q000008:administration & dosage*; D004041:Dietary Fats / Q000008:administration & dosage; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000178:diet therapy / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010636:Phenols / Q000008:administration & dosage*; D011341:Probucol / Q000008:administration & dosage*
D004041:Dietary Fats; D010636:Phenols; D002792:Cholestyramine Resin; D002784:Cholesterol; D011341:Probucol