title: Effects of ammonium chloride on urinary pH and cigarette smoking behavior.
abstract: We determined the effects of acidification of urinary pH on cigarette smoking behavior to assess the postulated relationships between stress, urinary pH, and cigarette smoking. Urine was acidified by short-term administration of 12.5, 25, and 50 mg/kg ammonium chloride and long-term administration of 50 mg/kg ammonium chloride. Measurements of cigarette smoking behavior included the number of cigarettes smoked as well as automated measures of puff frequency and duration. Short- and long-term administration of ammonium chloride induced decreases in urinary pH but failed to induce any substantial changes in number of cigarettes smoked, puff frequency, or puff duration.
mesh_terms: D000643:Ammonium Chloride / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D009538:Nicotine / Q000378:metabolism; D012907:Smoking; D014556:Urine
chemical_list: D000643:Ammonium Chloride; D009538:Nicotine