[Evaluation of stat assay of serum digoxin concentration by radioimmunoassay and its application for digoxin regimen based in pharmacokinetics (author's transl)].
Serum digoxin concentration measured by stat RIA (phadebas digoxin RIA kit) correlated well with results obtained by complete assays. The results of stat assay can be reported within 1 hour, measuring one or more samples together with 2 standard samples in duplicates. Precise measurement can be expected with serum digoxin concentration over 0.5 ng/ml. The stat assay allows to apply the theory of pharmacokinetics for the estimation of digoxin concentration at steady states measuring minimum digoxin concentration (Cn(min)) on the 3rd to 6th day after the start of digoxin therapy. The estimated serum digoxin levels were well agreed with measured values with the difference ranging from 1.6 to 8.6% in CV. The method is useful for the planning and assessment of appropriate digoxin regimen.
D000368:Aged; D004077:Digoxin / Q000097:blood* / Q000378:metabolism; D006333:Heart Failure / Q000097:blood; D006801:Humans; D007700:Kinetics; D008297:Male; D011863:Radioimmunoassay / Q000379:methods*; D011933:Reagent Kits, Diagnostic
D011933:Reagent Kits, Diagnostic; D004077:Digoxin