Cystinuria in children.
7 children, 20 months to 11 years old, with cystinuria and renal calculi were studied. Surgical treatment and alpha-mercaptopropionylglycine (MPG) gave satisfactory results in 5 children. The causes of the recurrences in the other 2 children are discussed. MPG therapy is effective but can cause a nephrotic syndrome at a dose of more than 50 mg/kg/day. A cystinuria of less than 200 mg/day cannot always be considered safe in children. The alkalinization and dilution of urine remain extremely important in the treatment of cystinuria.
D000603:Amino Acids, Sulfur / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003555:Cystinuria / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007223:Infant; D007669:Kidney Calculi / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D009404:Nephrotic Syndrome / Q000139:chemically induced; D012008:Recurrence; D008625:Tiopronin / Q000009:adverse effects / Q000627:therapeutic use*
D000603:Amino Acids, Sulfur; D008625:Tiopronin