title: [The pattern of cerebrospinal fluid proteins in infants and children. Determination of normal values (author's transl)].
abstract: Cerebrospinal fluid (CSF) protein values were measured in 652 children between the ages of 1 day and 17 years, allowing the authors to define the dynamics of the blood-brain barrier under normal conditions and during inflammation of the nervous system. The ratio of CSF albumin/serum albumin (whose upper limit was 0.65 in the study) was the best sign of alteration of blood-brain barrier permeability. The CSF IgG level, whose upper limit was 0.85 (for serum IgG between 10 and 14 g/l) is the most useful criterion for detecting an intra-thecal synthesis of IgG. Six patterns of CSF proteins are defined on the basis of immunochemical and electrophoretic studies. The ratio of CSF albumin/serum albumin and the CSF IgG level must be compared to the electrophoretic pattern of CSF proteins in order to better characterize one aspect of the blood-brain barrier under normal and pathologic conditions of the central nervous system.
mesh_terms: D000293:Adolescent; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis* / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004587:Electrophoresis, Agar Gel; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000134:cerebrospinal fluid; D007223:Infant; D007231:Infant, Newborn; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid; D012709:Serum Albumin / Q000134:cerebrospinal fluid
chemical_list: D002556:Cerebrospinal Fluid Proteins; D007074:Immunoglobulin G; D012709:Serum Albumin
vernacular_title: Profil protéique du liquide céphalo-rachidien chez l'enfant. Détermination des limites de référence.