[Comparison of the effects of gastroenteric and parenteral saline loading on kidney function after inhibition of prostaglandin synthesis (author's transl)].
We inhibited the prostaglandin synthesis with indomethacin in rats during a 7-h (periods: 1--4h; 4--5.5h; 5.5--7h) gastroenteric and parenteral infusion of isotonic saline. Indomethacin was given in a dosis of 10 mg/kg of b. wt. by stomach tube after 5.5-h infusion of saline. We studied how far prostaglandins are involved in the different function of the kidney by measuring the water and sodium excretion and the cortico-medullary osmotic and albumin concentrations of the kidney.


RESULTS
1. a) Studies Without Indomethacin. As compared to infusion of isotonic saline into the stomach water excretion is decreased by 30% (P less than 0.02) and 35% (P = n.s.) in the second and third 90 min period during parenteral infusion of saline. As compared to gastroenteric infusion we found an increase of the total osmolarity by 13% (P less than 0.02) in the cortex of the kidney. b) Studies with Indomethacin. As compared to saline infusion into the stomach indomethacin-treated rats decrease their urinary flow rates in 90 min by 26% (P = n.s.) in the presence of equivalent saline infusion into the aorta. Total osmolarity of the parenteral loaded rats increases by 17% (P less than 0.01) in the cortex of the kidney. 2. Indomethacin leads to an increased concentrating ability of the kidney in both gastroenteric and parenteral loaded rats. 3. In the presence of indomethacin plasma albumin of the kidney increases in the cortex and in the outer medulla of the kidney. In the inner medulla, and in the papillary tip, however, albumin concentration decreases significantly. As compared to gastroenteric saline infusion, the osmolarity of the kidney tissue increases and the urinary flow rate decreases during equivalent parenteral infusion of isotonic saline. The prostaglandins are not responsible for the pronounced diuresis during infusions of isotonic saline into the stomach.
D000818:Animals; D007213:Indomethacin / Q000494:pharmacology*; D007263:Infusions, Parenteral; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism; D012964:Sodium / Q000097:blood; D012965:Sodium Chloride / Q000494:pharmacology*; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D011453:Prostaglandins; D012709:Serum Albumin; D012965:Sodium Chloride; D012964:Sodium; D007213:Indomethacin
Vergleichende Untersuchungen zur Wirkung gastroenteraler und parenteraler Kochsalzinfusionen auf die Nierenfunktion nach Hemmung der Prostaglandinsynthese.