Drug discrimination learning in lead-exposed rats.
Lead acetate (0.02 or 0.5 percent) was administered to dams throughout the lactation period with half of the litters continuing on lead after weaning. Drug thresholds for d-amphetamine were determined by using the drug-discrimination learning paradigm. All the offspring that had been exposed to lead were less sensitive to the stimulus properties of d-amphetamine irrespective of whether or not they had continued on lead after weaning.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology*; D004193:Discrimination Learning / Q000502:physiology*; D004195:Disease Models, Animal; D005260:Female; D005333:Fetus / Q000187:drug effects; D007855:Lead Poisoning / Q000503:physiopathology*; D008297:Male; D011247:Pregnancy; D051381:Rats
D003913:Dextroamphetamine