Epoxide hydratase and glutathione S-transferase activities in human lungs.
It has been reported human lung has cytochrome P-450 dependent monooxygenase activity which is necessary for the formation of mutagenic and carcinogenic metabolites of polycyclic aromatic hydrocarbons, such as benzo[a]pyrene. We now report epoxide hydratase and glutathione S-transferase, enzymes important in the further metabolism of certain benzo[a]pyrene metabolites formed by the monooxygenase system, have been detected in human lung tissues from patients undergoing surgery for lung cancer.
D001580:Benzopyrenes / Q000378:metabolism; D004851:Epoxide Hydrolases / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000201:enzymology*; D008175:Lung Neoplasms / Q000201:enzymology
D001580:Benzopyrenes; D005982:Glutathione Transferase; D004851:Epoxide Hydrolases