[Maximal response of the rat vas deferens. II. Studies on the effect of variations in external K+ and the response to noradrenaline of preparations which were depolarized and exposed to various concentrations of extracellular Ca+].
The mechanical response of the rat vas deferens observed following administration of single or cumulative doses of K+ was studied and then the influence of external Ca2+ on the K+ response was investigated. The response of the preparation to noradrenalin when the concentration of K+ and/or Ca2+ is different from the physiological one was also studied. The results indicate that the ability of K+ to increase free intracellular Ca2+ concentration is greater than that of noradrenalin; there is an increase in the maximal response to noradrenalin on increasing the external concentration of K+ and/or Ca2+.
D000818:Animals; D002118:Calcium / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D014649:Vas Deferens / Q000187:drug effects
D011188:Potassium; D002118:Calcium; D009638:Norepinephrine
Studio delle risposte massimali del vas deferens di ratto. Nota II - Studio dell'influenza delle variazioni del K+ esterno e della risposta alla noradrenalina dei preparati depolarizzati ed esposti a diverse concentrazioni di Ca2+ extracellulare.