title: Effect of intravenous glucagon on the biliary secretion of a cholangiographic agent in man.
abstract: This study was undertaken in an attempt to define the mechanism whereby intravenous glucagon enhanced bile duct and gallbladder opacification at the time of infusion cholangiography. Seven post-operative gallstone patients with indwelling t-tubes were given a 1 h infusion of intravenous iotroxamide at a rate of 4.1 mg/kg body weight/min. Bile samples were collected by gravity drainage and assayed for iotroxamide and hence biliary iodine concentration. At the end of the 1 h infusion the mean biliary excretion rate (+/- s.e.m.) of iotroxamide was 26.1 +/- 3.4 mg/min and the iodine concentration in bile 9.7 +/- 1.2 mg/ml. 1 mg of intravenous glucagon given over 30 s at the end of the iotroxamide infusion produced a significant increase in bile flow (P less than 0.01). The excretion rate of iotroxamide rose rapidly following glucagon to reach a peak value of 43.8 +/- 8.1 mg/min 5 min after the glucagon (P less than 0.05). The enhanced biliary excretion of iotroxamide resulting from the glucagon injection was significant (P less than 0.05) 1, 3 and 5 but not 10 min after the hormone. The intravenous glucagon also caused a small but significant (P less than 0.05) elevation of the biliary iodine concentration to 10.9 +/- 1.2 mg/ml, 3 min after its injection, but by 5 min post-glucagon the iodine concentration in bile had reversed to pre-injection levels. The possible clinical implications of these results are discussed.
mesh_terms: D000328:Adult; D000368:Aged; D001646:Bile / Q000378:metabolism*; D002758:Cholangiography; D003287:Contrast Media / Q000378:metabolism*; D004347:Drug Interactions; D005260:Female; D005934:Glucagon / Q000494:pharmacology*; D006801:Humans; D007455:Iodine / Q000378:metabolism; D007458:Iodipamide / Q000031:analogs & derivatives* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D003287:Contrast Media; C012386:meglumine iotroxinate; D005934:Glucagon; D007455:Iodine; D007458:Iodipamide