Acute toxic methemoglobinemia following dental analgesia.
This communication reports a case of acute toxic methemoglobinemia associated with hypoxia and general motor seizures following dental anesthesia using nitrous oxide and prilocaine hydrochloride. The dosage of prilocaine hydrochloride used was 5.6% of the recognized toxic dosage associated with clinical methemoglobinemia. The patient had no demonstrable congenital tendency toward methemoglobinemia, suggesting this case may represent a previously unreported and potentially fatal reaction to prilocaine hydrochloride. The etiology of the methemoglobin production, the diagnosis of the syndrome, and the emergency treatment are discussed.
D000208:Acute Disease; D000766:Anesthesia, Dental / Q000009:adverse effects*; D002675:Child, Preschool; D006801:Humans; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced* / Q000188:drug therapy; D009609:Nitrous Oxide / Q000009:adverse effects*; D011318:Prilocaine / Q000009:adverse effects*
D011318:Prilocaine; D009609:Nitrous Oxide