Acrylamide induced inhibition of hepatic glutathione-S-transferase activity in rats.
Rats injected i.p. with acrylamide (50 mg/kg/day) for 5 days showed a significant inhibition of hepatic glutathione-S-transferase (GST) activity; maximum inhibition occurred in 15-day-old rats in which early development of hind limb paralysis was noted. Addition of acrylamide in vitro to the assay system also inhibited GST activity. No changes were observed in oxidized and reduced glutathione contents.
D000178:Acrylamides / Q000494:pharmacology*; D000818:Animals; D005260:Female; D005978:Glutathione / Q000031:analogs & derivatives / Q000378:metabolism; D019803:Glutathione Disulfide; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D008658:Inactivation, Metabolic; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D010243:Paralysis / Q000139:chemically induced; D051381:Rats
D000178:Acrylamides; D005982:Glutathione Transferase; D005978:Glutathione; D019803:Glutathione Disulfide