Tumorigenicity of minute dose levels of N-methyl-N-formylhydrazine of Gyromitra esculenta.
Separate administrations of 0.0005 to 0.00025% N-methyl-N-formylhydrazine in drinking water to 6-week-old randomly bred Swiss mice for the remainder of their lifetime induced lung neoplasms. At the high dose level, 64% of the females and 48% of the males developed lung tumors, while the corresponding tumor incidences at the lower dose level were 62% in the females and 54% in the males. In untreated controls, the lung tumor incidences were 29% in the females and 19% in the males. Histopathologically, the lesions were classified as adenomas and adenocarcinomas of the lungs. N-methyl-N-formylhydrazine is a stable constituent of the edible false morel mushroom Gyromitra esculenta. The environmental significance is discussed, in view of the carcinogenicity of minute doses of this chemical.
D000230:Adenocarcinoma / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D001487:Basidiomycota / Q000032:analysis*; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D008763:Methylhydrazines / Q000633:toxicity*; D051379:Mice; D009002:Monomethylhydrazine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000633:toxicity*; D009369:Neoplasms / Q000139:chemically induced*
D008763:Methylhydrazines; C016577:N-methyl-N-formylhydrazine; D009002:Monomethylhydrazine