Busulphan-induced chromosomal aberrations in intestinal cells of Chinese hamster.
Chinese hamsters were given Busulphan, 25 and 50 mg/kg bw. After 18 h, chromosomes of the lining cells of the upper intestinal tract were prepared according to a newly developed method. The aberration rate was enhanced by a factor of about 25 after 25 mg/kg, but 50 mg/kg bw did not induce higher aberration rates. In the same animals the dose-dependent aberration rates were also determined in bone-marrow cells. Furthermore, the formation of SCEs in intestinal cells was observed. In a preliminary experiment, metaphase plates from intestinal cells of mice were prepared, too.
D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure; D002066:Busulfan / Q000494:pharmacology*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D003434:Crossing Over, Genetic / Q000187:drug effects*; D004386:Duodenum / Q000166:cytology / Q000187:drug effects*; D007583:Jejunum / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D002066:Busulfan