title: Susceptibility of Legionella pneumophila to three cooling tower microbicides.
abstract: Investigation of epidemic outbreaks of Legionnaires disease by Center for Disease Control personnel has resulted in the isolation of Legionella pneumophila from water in the air-conditioning cooling towers or evaporative condensers at the site of the outbreak. It is suspected that improperly maintained open, recirculating water systems may play a role in the growth and dissemination of this pathogen. The objective of this study was to determine the antimicrobial activity of three chemically different, commercially available, cooling tower microbicides against L. pneumophila. Using two in vitro test systems, a combination of N-alkyl dimethyl benzyl ammonium chloride and bis (tri-n-butyltin) oxide was found to kill L. pneumophila at a concentration 25 times less than the minimum recommended use concentration, whereas N-alkyl 1,3-propanediamine and methylene bis (thiocyanate) were active at concentrations equal to or greater than the concentrations recommended for use by the manufacturer.
mesh_terms: D001548:Benzalkonium Compounds / Q000494:pharmacology; D003959:Diamines / Q000494:pharmacology; D004202:Disinfectants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007875:Legionella / Q000187:drug effects* / Q000254:growth & development; D013861:Thiocyanates / Q000494:pharmacology; D014220:Trialkyltin Compounds / Q000494:pharmacology
chemical_list: D001548:Benzalkonium Compounds; D003959:Diamines; D004202:Disinfectants; D013861:Thiocyanates; D014220:Trialkyltin Compounds; C005961:bis(tri-n-butyltin)oxide; C009475:trimethylenediamine; C028912:methylene bis(thiocyanate)