title: Results of local excision and radical radiotherapy in early breast cancer.
abstract: Twenty-seven patients with a T1 or T2 N0M0 breast carcinoma were treated by local excision of the lump followed by radical radiotherapy, using orthovoltage X-rays. The crude survival rate was 100% at three years, 92% at five years, 95% at 10 years. The local recurrence rate was 8% at three years, 12% at five years, 10.5% at 10 years. The radiation dose needed to be tumour lethal is discussed. Our results and those of papers quoted indicate that 4500--5000 cGy (rad) in five weeks, given in five fractions per week, is optimal, provided the primary tumour has ben removed. A further 1000--2000 cGy to the lumpectomy site reduces the incidence of local recurrence. The cosmetic results of our treatment are illustrated. Some telangiectasis was seen but the general appearance and texture of the treated breasts was satisfactory.
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006801:Humans; D008722:Methods; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011879:Radiotherapy Dosage