title: An unusual inhibition of an anti-P1.
abstract: Tests for unexpected antibodies using commercially prepared red blood cells demonstrated no agglutination even though crossmatching and testing with saline washed commercially prepared reagent red blood cells identified an anti-P1. This antibody was inhibited when tested with red blood cells suspended in a modified Alsever's solution and several commercially prepared reagent red blood cell diluents. The inhibitory substance was identified as inosine. Hypoxanthine, adenine, and thymine also inhibited the anti-P1. Partial inhibition was produced by uracil, 5-methylcytosine, and xanthine. No other example of anti-P1 has been found to exhibit this unusual inhibiting characteristic.
mesh_terms: D000906:Antibodies / Q000276:immunology*; D001789:Blood Group Antigens / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007288:Inosine / Q000494:pharmacology; D008875:Middle Aged; D009994:Osmolar Concentration; D010127:P Blood-Group System / Q000276:immunology*
chemical_list: D000906:Antibodies; D001789:Blood Group Antigens; D010127:P Blood-Group System; D007288:Inosine