The effect of melperon on ocular readaptation time, as assessed by a new recording technique.
A new simplified technique recording readaptation time after photo stress, RAT, is described. The psychometric properties in terms of internal consistency and retest reliability were tested, and the effect on RAT after intake of melperon at two different dose levels was investigated and correlated to blood plasma levels. The results show that there was a satisfactory consistency of RAT at each occasion but stability over a 1 month period could not be demonstrated. Significantly dose-dependent changes were recorded after intake of melperon but the prolongation of RAT was not significantly correlated to blood plasma levels.
D000221:Adaptation, Ocular / Q000187:drug effects*; D000284:Administration, Oral; D000328:Adult; D002090:Butyrophenones / Q000494:pharmacology*; D005133:Eye Movements / Q000187:drug effects; D005260:Female; D006801:Humans; D008027:Light; D008297:Male; D009885:Ophthalmology / Q000295:instrumentation / Q000379:methods; D010076:Oxazepam / Q000008:administration & dosage / Q000494:pharmacology*
D002090:Butyrophenones; D010076:Oxazepam; C008522:metylperon