Dose response of 1,2-dimethylhydrazine and methylazoxymethanol acetate in the F 344 rat.
Weanling male and female F 344 rats were given various doses of 1,2-dimethylhydrazine (DMH) or methylazoxymethyl acetate (MAMAc), and were then held for 46-64 weeks in an effort to determine a dose response and establish a dose level which would produce a low level of intestinal neoplasia with a minimal number of tumors in other organs. DMH proved superior to MAM in this respect, although liver lesions were still observed with both compounds at the lowest carcinogenic intestinal dose.
D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D004127:Dimethylhydrazines / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D008746:Methylazoxymethanol Acetate / Q000633:toxicity*; D008763:Methylhydrazines / Q000633:toxicity*; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D011916:Rats, Inbred F344; D012626:Sebaceous Gland Neoplasms / Q000139:chemically induced
D001391:Azo Compounds; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D008746:Methylazoxymethanol Acetate