Influence of early phases of paralysis on microcirculation of rat skeletal muscle.
By combining tissue pO2 measurements with morphological visualization and counting of perfused capillaries, early microvascular changes were investigated in paralysis of skeletal muscle of the rat. The models included experimental allergic encephalomyelitis (EAE), experimental allergic neuritis (EAN), 6-aminonicotinamide intoxication, and peripheral denervation. The results showed that in all models tissue oxygenation was either normal or elevated. In most cases this was accompanied by a reduced perfusion of the capillary bed, supporting the hypothesis of a dysfunction in oxidative metabolism. The effects of paralysis on capillary perfusion were more marked in red than in white muscles, except in spastic paresis. Flaccid paralysis had more deleterious effects on muscle microcirculation than spastic paralysis. Our data suggest that: (1) microvascular changes occur very early after the onset of paralysis and (2) later developing changes in the skeletal muscle such as atrophy cannot be ascribed to a lack of oxygen supply but rather, at least in part, to a dysfunction in oxidative metabolism.
D015120:6-Aminonicotinamide / Q000494:pharmacology; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000503:physiopathology; D008833:Microcirculation / Q000187:drug effects; D009121:Muscle Denervation; D009132:Muscles / Q000098:blood supply*; D009443:Neuritis / Q000503:physiopathology; D010100:Oxygen / Q000097:blood; D010243:Paralysis / Q000139:chemically induced / Q000503:physiopathology*; D051381:Rats
D015120:6-Aminonicotinamide; D010100:Oxygen