Effect of arterial stretch on transmural albumin and Evan's blue dye transport.
The influence of arterial wall circumferential stretch (lambda) on the 32-min diffusive mural uptake of 125I-albumin and of Evan's blue dye (EBD) across the injured endothelial surface was studied in the intimal-medial preparation of the canine descending thoracic aorta (DTA). Albumin uptake (MA nmol/cm2) was measured by standard gamma counting techniques and the corresponding EBD uptake (ME) by the reflectance method. MA and ME were measured at a physiological stretch (lambda = 1.4) and at a hypertensive stretch (lambda = 1.8) at four equispaced locations (z) along the DTA. When lambda was changed from 1.4 to 1.8, the average percentage change of MA was -2% and of ME was -4%. These decreases were not significant (P greater than 0.10), and we conclude that arterial wall stretch exerts only minor influence on the parameters governing albumin and EBD-albumin accumulation in the intimal surface of the deendothelialized arterial intimal-medial tissue system.
D000042:Absorption; D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism*; D001391:Azo Compounds / Q000378:metabolism*; D001692:Biological Transport; D004285:Dogs; D005070:Evans Blue / Q000378:metabolism*; D066298:In Vitro Techniques; D008433:Mathematics; D012709:Serum Albumin / Q000378:metabolism*; D013314:Stress, Mechanical; D013997:Time Factors
D001391:Azo Compounds; D012709:Serum Albumin; D005070:Evans Blue