[Hepatic and intestinal toxicity of furazan and furoxan derivatives].
Histological examination revealed that 4-methylfurazan-3-carboxylic acid hydrazide (I); 3-methylfuroxan-4-carboxylic acid hydrazide (II); 4-methylfurazan-3-carboxylic acid amide(III); 4-methylfuroxan-3-carboxylic acid amide (IV), caused hepatic and intestinal lesion in the mouse. At the higher doses a destruction of the intestinal mucosa and a vasodilatation of the hepatic sinusoid was observed. At lower doses hepatic steatosis was observed.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D007413:Intestinal Mucosa / Q000187:drug effects; D007422:Intestines / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D010069:Oxadiazoles / Q000633:toxicity*; D013231:Steatitis / Q000139:chemically induced
D010069:Oxadiazoles; C029288:3-methylfurazan-4-carboxamide; C029286:3-methylfurazan-4-carboxylic acid hydrazide; C029289:3-methylfuroxan-4-carboxamide; C029287:3-methylfuroxan-4-carboxylic acid hydrazide
Tossicita' epatica e intestinale di alcuni derivati furazanici e furossanici.