Prostaglandin E1 infusion in newborns with hypoplastic left ventricle and aortic atresia.
Prostaglandin E1 (PGE1) infusion was used in 7 infants with hypoplastic left ventricle and aortic atresia. Of 5 non-operated patients, 4 died shortly after the onset of PGE1 infusion and 1 survived for 30 hours. Of the infants who had surgery, 1 died during the operation and 1 survived for 38 days. In 6 infants, a transient metabolic and/or circulatory improvement could be demonstrated following PGE1 infusion. The lack of response of other infants may be related to the advanced deterioration of their clinical status at the time of study. In the light of recent surgical developments for infants with aortic atresia, support with PGE1 may nevertheless play an important role in their management if started early.
D000015:Abnormalities, Multiple / Q000188:drug therapy / Q000401:mortality / Q000601:surgery; D000138:Acidosis / Q000150:complications; D000142:Acidosis, Respiratory / Q000150:complications; D000527:Alprostadil; D001013:Aorta, Thoracic / Q000002:abnormalities* / Q000187:drug effects / Q000601:surgery; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006352:Heart Ventricles / Q000002:abnormalities* / Q000187:drug effects / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D007263:Infusions, Parenteral; D008297:Male; D011458:Prostaglandins E / Q000008:administration & dosage / Q000627:therapeutic use*
D011458:Prostaglandins E; D000527:Alprostadil