Cure of mice infected with Trypanosoma rhodesiense by cis-diamminedichloroplatinum (II) and disulfiram rescue.
Mice infected with Trypanosoma rhodesiense were treatment concurrently with cis-diamminedichloroplatinum (II) (DDP), disulfiram, and hydration. Most of the mice (92.5 percent) were cured; inoculation of blood or suspensions of brain or heart from these animals did not produce disease in recipient mice. The dose of DDP needed to eliminate the trypanosomes, 3 milligrams per kilogram of body weight per day for 7 days, was lethally toxic unless the animals received disulfiram orally and subcutaneous injections of physiologic saline, which reduced the acute renal necrosis caused by DDP alone. Some mild to moderate reversible renal damage was noted upon pathologic examination of the treated mice.
D000818:Animals; D002945:Cisplatin / Q000009:adverse effects; D004221:Disulfiram / Q000008:administration & dosage*; D007668:Kidney / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009336:Necrosis / Q000139:chemically induced; D051381:Rats; D012965:Sodium Chloride / Q000008:administration & dosage; D014345:Trypanosoma / Q000187:drug effects; D014353:Trypanosomiasis, African / Q000473:pathology / Q000628:therapy*
D012965:Sodium Chloride; D002945:Cisplatin; D004221:Disulfiram