title: Effect of defibrinogenation on collagen synthesis in granulation tissue. A study in the rabbit.
abstract: Collagen synthesis was studied in sponge-induced early granulation tissue from rabbits defibrinogenated by Arvin. Tissue slices were incubated in vitro with 14C-proline. The formation of 14C-hydroxyproline and the incorporation of 14C-proline into proteins was determined. The incorporation of proline into collagen and proteins was equally reduced after defibrinogenation. A possible explanation for this is a reduced number of active fibroblasts in granulation tissue formed during defibrinogenation.
mesh_terms: D000347:Afibrinogenemia / Q000378:metabolism*; D000818:Animals; D003094:Collagen / Q000096:biosynthesis*; D005260:Female; D006097:Granulation Tissue / Q000378:metabolism*; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D011392:Proline / Q000378:metabolism; D011817:Rabbits
chemical_list: D003094:Collagen; D011392:Proline; D006909:Hydroxyproline