title: Ventricular tachycardia in children.
abstract: Thirty-eight patients aged 1 to 20 years (mean 11.2) were evaluated because of recurrent ventricular tachycardia. The follow-up period ranged from 0.5 to 12 years (mean 6). The patients were separated into two groups according to the presence or absence of known structural heart disease. Seventeen of the 21 patients with known heart disease were symptomatic (cardiac arrest in 5, syncope in 5, dizziness in 7) compared with only 6 of the 17 patients without heart disease (syncope in 3 and dizziness in 3) (p less than 0.01). All symptomatic patients had ventricular tachycardia with rates of more than 150 beats/min, whereas all but one of the asymptomatic patients had rates of less than 150 beats/min (p less than 0.01). Graded treadmill exercise testing was performed in 21 of the 38 patients. Exercise increased the degree of ventricular arrhythmia in 8 of the 11 symptomatic patients but decreased or abolished the arrhythmia in 9 of the 10 asymptomatic patients (p less than 0.01). Antiarrhythmic therapy was used in 28 of the 38 patients. Effectiveness of therapy was assessed with both 24 hour Holter monitoring and graded treadmill exercise testing. Therapy effectively abolished ventricular tachycardia and greatly decreased the number of premature ventricular complexes in the symptomatic patients but was less effective in the asymptomatic patients. Thus, this study suggests that the presence of underlying heart disease, the rate of ventricular tachycardia and the results of graded treadmill exercise tests are important in predicting the prognosis of children with ventricular tachycardia.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004452:Echocardiography; D004562:Electrocardiography; D005080:Exercise Test; D006330:Heart Defects, Congenital / Q000150:complications; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D007223:Infant; D008945:Mitral Valve Prolapse / Q000150:complications; D009205:Myocarditis / Q000150:complications; D010672:Phenytoin / Q000627:therapeutic use; D011379:Prognosis; D013610:Tachycardia / Q000150:complications / Q000503:physiopathology*
chemical_list: D010672:Phenytoin