Aspirin inhibition of hypercalcemic effect of 1 alpha-hydroxyvitamin D3 in rats.
Interaction of calcium regulating hormone, active form of vitamin D3, and aspirin (ASA) was studied in rats. One alpha-hydroxyvitamin D3 (1 alpha-OH-D3) produced a hypercalcemia in parathyroidectomized, thyroparathyroidectomized and thyroparathyroidectomized nephrectomized rats. The effect of 1 alpha-OH-D3 was inhibited by treatment with 200, 50 and 20 mg/kg p.o. of ASA. ASA did not stimulate the gut absorption of calcium in vitamin D deficient rats. These data suggest that ASA acts by inhibiting 1 alpha OH-D3 induced bone resorption. This is the first report demonstrating the inhibitory effect of ASA on bone resorption as induced by 1 alpha-OH-D3, although partial inhibition of bone resorption in vitro has been reported.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D001862:Bone Resorption / Q000187:drug effects; D002118:Calcium / Q000097:blood* / Q000378:metabolism; D006887:Hydroxycholecalciferols / Q000037:antagonists & inhibitors*; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D009392:Nephrectomy; D010280:Parathyroid Glands / Q000601:surgery; D051381:Rats; D013965:Thyroidectomy; D014808:Vitamin D Deficiency / Q000378:metabolism
D006887:Hydroxycholecalciferols; D001241:Aspirin; D002118:Calcium; C008088:alfacalcidol