[Blood serum electrolyte content in pigs during general anesthesia induced by administration of chloral hydrate, nembutal, eunarcon and brevinarcon].
Sixty pigs were used for the study. The animals were divided into 5 groups, 12 pigs in each. The following substances were administered intravenously in the individual groups: I -- 20 ml of physiological solution NaCl (placebo, II -- chloral hydrate (10% solution), III -- Nembutal, IV -- Eunarcon, V -- Brevinarcon (10% solution). Blood was collected from the anterior vena cava after 1 hour and after 1, 3 and 7 days since the moment of administration of physiological saline (group I), or since the appearance of general anaesthesia (groups II-V). Determinations in blood serum concerned: Na, K  and Ca -- with the use of a flame photometer, Mg -- by the method of Lange, Cl -- by the method of Schales and Schales, inorganic phosphorus -- by the Fiske-Subbarow method. The results were analysed statistically by determining the mean, the standard deviation and the significance of variations according to the t Student test (risk of error -- 5%). The results obtained in groups II-V were compared with the corresponding results from group I. It was found that chloral hydrate, Nembutal, Eunarcon and Brevinarcon, used to produce general anaesthesia in healthy pigs (not operated upon) produce a decrease in the sodium and potassium content, an increase in the magnesium and inorganic phosphorus content, and slight changes in the calcium and chlorine content. The greatest and most prolonged deviations were found after chloral hydrate and Nembutal the slightest after Brevinarcon. Eunarcon produced short-lived changes, but greater than after Brevinarcon. These changes in the level of electrolytes in serum should be attributed to disturbances of respiration (respiratory acidosis), and to decreased activity of muscles during anaesthesia in pigs.
D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000008:administration & dosage; D000818:Animals; D002697:Chloral Hydrate / Q000008:administration & dosage; D004573:Electrolytes / Q000097:blood*; D007275:Injections, Intravenous; D013552:Swine / Q000097:blood*
D000777:Anesthetics; D004573:Electrolytes; D002697:Chloral Hydrate
Zawartość elektrolitów w surowicy u świń w znieczuleniu ogólnym, wywołanym podaniem wodnika chloralu, nembutalu, eunarkonu i brevinarkonu.