Structural immunochemistry of melatonin-BSA binding, model of amino and indole groups cross-linking.
The sites of fixation to bovine serum albumin of melatonin and of mono- and dimethylated melatonin identified by mass spectrometry and nuclear magnetic resonance, have been determined. The binding sites appear to be important in the conservation of the structural features necessary for the antigenicity of the molecule.
D000588:Amines / Q000378:metabolism; D001665:Binding Sites; D007120:Immunochemistry; D007211:Indoles / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008550:Melatonin / Q000276:immunology / Q000378:metabolism*; D011485:Protein Binding; D012710:Serum Albumin, Bovine / Q000378:metabolism
D000588:Amines; D007211:Indoles; D012710:Serum Albumin, Bovine; D008550:Melatonin