Localisation of experimental staphylococcal abscesses by 99MTC-technetium-labelled liposomes.
The accumulation of 99mTc-technetium-labelled liposomes in abscesses was studied. Abscesses were produced in the thighs of albino rats by intramuscular injection of Staphylococcus aureus. After 4 days these abscesses were used to determine the localisation of 99mTc-technetium-labelled anionic, cationic and neutral liposomes in the abscess area. This was achieved by radionuclide images produced by a gamma camera and an associated data-processing system. There was a pronounced uptake of 99mTc-technetium-labelled anionic liposomes in the abscess area compared with the corresponding unaffected thigh. Similar uptake was not shown by the 99mTc-technetium-labelled cationic and neutral liposomes. Abscess uptake of anionic liposomes was maximal at or before 30 min after injection and was not enhanced by prior opsonisation with aggregated rat immunoglobulin.
D000038:Abscess / Q000000981:diagnostic imaging*; D000818:Animals; D003201:Computers; D007136:Immunoglobulins; D008081:Liposomes; D009895:Opsonin Proteins; D011877:Radionuclide Imaging; D051381:Rats; D013203:Staphylococcal Infections / Q000000981:diagnostic imaging*; D013667:Technetium
D007136:Immunoglobulins; D008081:Liposomes; D009895:Opsonin Proteins; D013667:Technetium