title: Differential loss of biological activity of the enkephalins induced by current.
abstract: Passage of current across solutions of enkephalins caused loss of biological activity of the peptides, this loss increasing as current strength was increased. The presence of a vas deferens tissue prevented the current-induced loss of activity of Leu-enkephalin but had no effect on the loss of activity of Met-enkephalin. These results provide a possible explanation for the differential potency of the enkephalins on the vas and provide a reason for the inability of several laboratories to show electrically induced enkephalin release.
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D004723:Endorphins / Q000494:pharmacology*; D004743:Enkephalin, Leucine; D004744:Enkephalin, Methionine; D004745:Enkephalins / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009130:Muscle, Smooth / Q000502:physiology; D014649:Vas Deferens / Q000502:physiology
chemical_list: D004723:Endorphins; D004745:Enkephalins; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine