Acute obstructive uric acid nephropathy after treatment of neoplastic adenopathy.
Patients with lymphoma and leukemia are at increased risk of therapy-related sudden increase in the serum uric acid level, with resultant precipitation and obstruction in the more acidic and concentrated distal nephron. Appropriate pretreatment measures can prevent intrarenal crystal formation. The acute obstruction responds well to treatment, and aggressive measures are indicated.
D000208:Acute Disease; D002699:Chlorambucil / Q000627:therapeutic use; D003251:Constriction, Pathologic; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology*; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D014527:Uric Acid / Q000097:blood*
D002699:Chlorambucil; D014527:Uric Acid; D011241:Prednisone