Glucose infusions increase plasma levels of amyloid proteins in high density lipoproteins.
Malmendier et al. (4) have described six apoproteins from human plasma high density lipoproteins (HDL) which were isolated from patients given an intravenous infusion of 10% glucose. Inspection of their amino-terminal sequences indicate that Malmendier et al. have isolated various forms of serum amyloid AA. Since amyloid is present in patients with various chronic diseases which are associated with decreased HDL levels, we suggest that there is a relationship between amyloid and HDL.
D000595:Amino Acid Sequence; D000682:Amyloid / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007263:Infusions, Parenteral; D008075:Lipoproteins, HDL / Q000097:blood*; D000685:Serum Amyloid A Protein / Q000378:metabolism*
D000682:Amyloid; D001786:Blood Glucose; D008075:Lipoproteins, HDL; D000685:Serum Amyloid A Protein; D005947:Glucose