Investigations into some pharmacological actions of ergometrine.
In contrast to the classical dopaminergic agonist, Eg did not stimulate ACh output from the cerebral cortex of anaesthetized rat. The effect of the drug on guinea-pig and rat vas deferens was mediated by alpha-adrenoceptors and the same is true for arterial blood pressure of rats. In the cardiovascular system of guinea-pig Eg behaved like Histamine.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004874:Ergonovine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D051381:Rats; D014649:Vas Deferens / Q000187:drug effects* / Q000378:metabolism
D000109:Acetylcholine; D004874:Ergonovine