[Synthesis and properties of nuclear hydroxylated derivatives of flufenamic acid and etofenamate (author's transl)].
Synthesis of six nuclear hydroxylated derivatives of flufenamic acid and etofenamate (5-OH-, 4'-OH and 5,4'-(OH2) on a preparative scale is described. All compounds show low toxicity, but only weak anti-inflammatory activity in the rat paw kaolin edema test as compared to 2-(2-hydroxyethoxy)ethyl-N-(a,a,a-trifluoro-m-tolyl)-anthranilate (etofenamate, active substance of Rheumon Gel).
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005439:Flufenamic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats
D000893:Anti-Inflammatory Agents; D005439:Flufenamic Acid; C015207:etofenamate
Synthesen und Eigenschaften kernhydroxylierter Derivate von Flufenaminsäure und Etofenamat.