title: 2-(Aminomethyl)phenols, a new class of saluretic agents. 2. Synthesis and pharmacological properties of the 5-aza isostere of 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenol.
abstract: The synthesis and biological evaluation of 4-(aminomethyl)-6-(1,1-dimethylethyl)-2-iodo-3-pyridinol dihydrochloride (7b) are described. Compound 7b proved to be highly active as a saluretic diuretic in both rats and dogs.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004232:Diuretics / Q000138:chemical synthesis* / Q000494:pharmacology; D004285:Dogs; D004573:Electrolytes / Q000652:urine; D006973:Hypertension / Q000503:physiopathology; D007469:Iodopyridones / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
chemical_list: D004232:Diuretics; D004573:Electrolytes; D007469:Iodopyridones; C029120:4-(aminomethyl)-6-(1,1-dimethylethyl)-2-iodo-3-pyridinol