title: The use of cisplatinum for treatment of malignant glioma.
abstract: Standard chemotherapy for malignant gliomas has not generally been successful. Recent reports have suggested that cis-diammine-dichloroplatinum is preferentially accumulated into brain tumors compared to surrounding brain tissue. A patient who had failed radiation treatments and multiple other chemotherapeutic agents responded both clinically and radiographically to this new drug. This clinical observation, when combined with the tissue distribution of cis-diamminedichloroplatinum, would indicate that further evaluation of this new agent in the treatment of brain malignancies is warranted.
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002330:Carmustine / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use*; D005910:Glioma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D002945:Cisplatin; D002330:Carmustine