title: Vasopressin analogs that antagonize antidiuretic responses by rats to the antidiuretic hormone.
abstract: Four new synthetic analogs of vasopressin (antidiuretic hormone) can antagonize the antidiuretic response to intravenous vasopressin in anesthetized, water-loaded rats. They also cause a diuresis resembling that of diabetes insipidus when given intraperitoneally to conscious rats. Such antagonists may prove to be useful both pharmacologically and therapeutically.
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects*; D005260:Female; D009994:Osmolar Concentration; D051381:Rats; D013329:Structure-Activity Relationship; D014667:Vasopressins / Q000037:antagonists & inhibitors*
chemical_list: D014667:Vasopressins; D001127:Arginine Vasopressin; C028883:argipressin, beta-mercapto beta,beta-cyclopentamethylenepropionic acid(1)-O-methyl-Tyr(2)-Val(4)-; C028884:1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-2-(O-ethyl-Tyr)-4-Val-arginine vasopressin