Residence time and accumulation of drugs in the body.
This investigation presents a simple and clinically useful theory of drug accumulation based on the mean residence time of drug molecules in the plasma compartment. The parameters decay fraction and accumulation factor, defined in terms of average steady-state amount in the body, are used to characterize the pharmacokinetics of multiple dosing. These parameters are calculated for digoxin and digitoxin.
D004074:Digitoxin / Q000378:metabolism; D004077:Digoxin / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D004364:Pharmaceutical Preparations; D004077:Digoxin; D004074:Digitoxin