The use of spinal cord cell cultures in the study of neurotoxicological agents.
Primary cell cultures of mouse embryo spinal cords were used to study the biological effects of exposure to organophosphate esters and neurotoxic amino acids. The effects of exposure were correlated with markers of cholinergic function. The purpose of this study was to examine the mechanisms whereby xenobiotics produce neurotoxicologic damage.
D000818:Animals; D002478:Cells, Cultured; D005971:Glutamates / Q000633:toxicity*; D007531:Isoflurophate / Q000633:toxicity; D007608:Kainic Acid / Q000633:toxicity*; D051379:Mice; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010261:Paraoxon / Q000633:toxicity; D011759:Pyrrolidines / Q000633:toxicity*; D012970:Sodium Glutamate / Q000633:toxicity*; D013116:Spinal Cord / Q000187:drug effects*
D005971:Glutamates; D009943:Organophosphorus Compounds; D011759:Pyrrolidines; D007531:Isoflurophate; D010261:Paraoxon; D007608:Kainic Acid; D012970:Sodium Glutamate