title: Autogenous vein graft thrombosis following exposure to calcium-free solutions (calcium paradox).
abstract: The morphological and functional effects of calcium-free and calcium-containing solutions on canine jugular vein intima were examined under conditions which closely resemble those techniques currently employed in peripheral vascular and aortocoronary bypass surgery. Veins that had been exposed only to calcium-containing solutions remained patent for the duration of the experimental period. Vein perfusion with a calcium-free solution, however, resulted in disruption of the jugular vein intima once calcium ions were reintroduced. Autogenous as a femoral arterial graft became thrombosed within 60 minutes. It is therefore suggested that vein grafts of autogenous origin be irrigated with calcium-containing solutions to prevent intimal damage and thrombosis.
mesh_terms: D000818:Animals; D002118:Calcium; D004285:Dogs; D005260:Female; D007601:Jugular Veins / Q000637:transplantation* / Q000648:ultrastructure; D008297:Male; D008855:Microscopy, Electron, Scanning; D012996:Solutions; D013927:Thrombosis / Q000209:etiology*; D014182:Transplantation, Autologous
chemical_list: D012996:Solutions; D002118:Calcium