p-Toluenesulfonic acid/methanol: mild reagent for the preparation of bile acid methyl esters.
An improved method for the preparation of bile acid methyl esters is described. This is achieved by the addition of catalytic amounts of p-toluenesulfonic acid in a solution of bile acid in methanol. Advantages of this procedure over conventional methods include (1) use of a mild solid acid catalyst which prevents the formation of undesirable byproducts, (2) isolation of a solid product of high purity and (3) utilization of a relatively safe reagent in comparison to other methods involving diazomethane, hydrochloric acid or sulfuric acid.
D001557:Benzenesulfonates; D001647:Bile Acids and Salts / Q000138:chemical synthesis*; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D007202:Indicators and Reagents; D000432:Methanol
D001557:Benzenesulfonates; D001647:Bile Acids and Salts; D007202:Indicators and Reagents; C029501:4-toluenesulfonic acid; D000432:Methanol