Synthesis and antitumor activity of seleno- and thio-purines complexed with cis-diamminoplatinum (II).
cis-Diamminoplatinum (II) complexes with selenoguanine, thioguanine, 6-thioxanthine, or 6-mercaptopurine were synthesized by the reaction of stoichiometric amounts of selenopurine or thiopurine with aquated cis-dichlorodimmineplatinum (II) in slightly acidic medium, and their antitumor activity was studied against L1210 cells in mice. These compounds exhibited a medium antitumor activity with very low toxicity. The antitumor activity was dependent on the nature of the purine ligand. These complexes were very stable in various aqueous solvents at 37 degrees C for 10 d but not in the presence of mouse serum. The mechanism of the action effected by the complex is not clear. However, the slow release of an antitumor active purine from the complex, SeG-Pt (NH3)2, was observed.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001681:Biological Assay; D055598:Chemical Phenomena; D002621:Chemistry; D002945:Cisplatin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D004355:Drug Stability; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D011687:Purines / Q000138:chemical synthesis / Q000494:pharmacology; D013997:Time Factors
D000970:Antineoplastic Agents; D011687:Purines; D002945:Cisplatin