Effect of reduced vitamin K esters on vitamin K-dependent carboxylation.
The hypothesis of a vitamin K hydroquinone hemicarbonate as intermediate of vitamin K-dependent carboxylation of glutamic residues, has been examined, by testing several vitamin K hydroquinone esters as inhibitors of the reaction. Among the esters that have been synthetized, a monoacetate proved to be an inhibitor. Kinetic analysis shows that the inhibition is no competitive with respect to vitamin K.
D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D007700:Kinetics; D008862:Microsomes, Liver / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D013329:Structure-Activity Relationship; D014812:Vitamin K / Q000494:pharmacology*; D010837:Vitamin K 1 / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D001639:Bicarbonates; D014812:Vitamin K; C028843:vitamin K1 hydroquinone; D010837:Vitamin K 1