Some comparisons between induced and spontaneous mutation rates in mouse sperm and spermatogonia.
The induction of histocompatibility gene mutations in BALB/cKh mouse sperm was determined following doses of 0, 350, or 350 + 300 rad (24 h apart) of 250 kV X-rays. The mutation rate is significantly lower than predicted on the basis of the seven-locus test and is not significantly different from the very low rate of H-loci in BALB/cKh spermatogonia. Furthermore, selection and repair are important in determining mutation rates per viable progeny of H-loci during both spermatogenesis and gestation.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005796:Genes / Q000528:radiation effects*; D006183:H-2 Antigens / Q000235:genetics*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics; D009154:Mutation; D013093:Spermatogonia / Q000528:radiation effects*; D013094:Spermatozoa / Q000528:radiation effects*; D014965:X-Rays
D006183:H-2 Antigens