Long-term studies of microencapsulated and adsorbed influenza vaccine nanoparticles.
Incorporation of antigens into nanometer-sized polymer particles was recently shown to lead to a good adjuvant effect. An optimal antibody response with killed influenza virus antigens was achieved with 0.5% poly(methyl methacrylate). Long-term experiments showed prolonged antibody response of polymer adjuvants with incorporated or adsorbed influenza virus. Adsorption also yielded an optimal adjuvant effect with 0.5% poly(methyl methacrylate). The antibody response was accompanied by protection of the mice against infection with mice-adapted influenza virus. In addition, the polymer vaccines were more stable against temperature inactivation than were vaccines with aluminum hydroxide or without adjuvants.
D000327:Adsorption; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D000956:Antigens, Viral; D002214:Capsules; D004355:Drug Stability; D005260:Female; D006358:Hot Temperature; D007252:Influenza Vaccines / Q000008:administration & dosage*; D008768:Methylmethacrylates / Q000494:pharmacology; D051379:Mice
D000914:Antibodies, Viral; D000956:Antigens, Viral; D002214:Capsules; D007252:Influenza Vaccines; D008768:Methylmethacrylates