Effects of cycloheximide administered in conjunction with nicotine on retention of a passive avoidance task in mice.
Retention of a passive avoidance task was studied in mice given either cycloheximide or cycloheximide in combination with nicotine. Two similar experiments were conducted: In the first experiment, the effects, of these drugs were studied in inbred C57Bl/6J mice. In the second experiment, the effects of these drugs were studied in genetically heterogenous mice. Cycloheximide was found to have a deleterious effect on retention of the passive avoidance task. Larger doses of cycloheximide were found to be necessary to disrupt memory in heterogenous mice than in C57Bl/6J animals. Nicotine, when administered in conjunction with cycloheximide, abolished the memory disruptive effects of cycloheximide. The results of these experiments are discussed in terms of a time-dependent consolidation model of memory storage.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003513:Cycloheximide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005838:Genotype; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D009538:Nicotine / Q000494:pharmacology*; D012153:Retention, Psychology / Q000187:drug effects*
D009538:Nicotine; D003513:Cycloheximide