Naloxone in the treatment of anorexia nervosa: effect on weight gain and lipolysis.
The effects of a constant intravenous infusion of naloxone in doses ranging from 3.2 to 6.4 mg/day were studied in a group of patients with anorexia nervosa. Patients showed a significantly greater weight gain during the infusion compared with the periods before and after naloxone. Plasma β-hydroxybutyrate and non-esterified fatty acid levels fell during the infusion. It is suggested that, in man, naloxone has an antilipolytic effect in vivo.
D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood / Q000188:drug therapy*; D001835:Body Weight / Q000187:drug effects; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D007263:Infusions, Parenteral; D008066:Lipolysis / Q000187:drug effects*; D009270:Naloxone / Q000008:administration & dosage / Q000627:therapeutic use*
D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D009270:Naloxone