[General pharmacology of (alpha RS)-3-formamido-4-hydroxy-alpha-[[[(alpha RS)-p-methoxy-alpha-methylphenethyl]amino]methyl] benzyl alcohol fumarate dihydrate (BD 40A), a new bronchodilator agent (author's transl)].
General pharmacological properties of BD 40A, a new bronchodilator agent, were investigated and the following results were obtained. BD 40A showed no effect on the central nervous system, and little effect on the autonomic nervous system. BD 40A produced an increase in heart and respiration rates, a decrease in blood pressure, and change in ECG in both anesthetized dogs and conscious animals. These effects of BD 40A were inhibited by propranolol (beta-blocker) administration. BD 40A potentiated carbohydrate and lipid metabolism in Beagle dogs. The pharmacological profile of BD 40A was similar to that of hexoprenaline which was used as the reference compound.
D000818:Animals; D000893:Anti-Inflammatory Agents; D001522:Behavior, Animal / Q000187:drug effects; D001993:Bronchodilator Agents / Q000494:pharmacology*; D002319:Cardiovascular System / Q000187:drug effects; D002415:Cats; D002490:Central Nervous System / Q000187:drug effects; D004285:Dogs; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D000068759:Formoterol Fumarate; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D008251:Macaca; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D001993:Bronchodilator Agents; D004983:Ethanolamines; D000068759:Formoterol Fumarate