[Studies on the release of solubilized drugs from ointment bases. Part 5: Influence of the volume of disperse phase on liberation of chloramphenicol from emulsifying ointments (author's transl)].
It has been shown that liberation of the chloramphenicol emulsive ointments depends on the rate of diffusion in the ointments basis. The rate of the diffusion depends on the volume of dispersion phase, effective coefficient of diffusion and on the concentration gradient.
D002701:Chloramphenicol; D004058:Diffusion; D004655:Emulsions; D007700:Kinetics; D008962:Models, Theoretical; D009823:Ointment Bases; D012995:Solubility
D004655:Emulsions; D009823:Ointment Bases; D002701:Chloramphenicol
Untersuchungen zur Liberation von solubilisierten Arzneistoffen aus Salbengrundlagen. 5. Mitteilung: Einfluss des Volumenanteils der hydroiphilen Phase auf die Liberation des Chloramphenicols aus Emulsionssalben.