title: [Tienilic acid, hyperuricemia and kidney function].
abstract: Tienilic acid (Diflurex) was given to 10 patients with secondary hyperuricemia following hydrochlorothiazide or furosemide administration. Eight of these 10 patients suffered acute worsening of renal function reflected in a significant increase in plasma creatinine. Plasma urates fell in all patients. Plasma creatinine returned to pretreatment levels in all patients within 4 to 15 days. Extreme caution should be exercised in prescribing tienilic acid to hyperuricemic patients, in view of the significant risk of reversible renal impairment.
mesh_terms: D000368:Aged; D003404:Creatinine / Q000097:blood; D005260:Female; D005665:Furosemide / Q000009:adverse effects / Q000627:therapeutic use; D006016:Glycolates / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects / Q000627:therapeutic use; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D013989:Ticrynafen / Q000627:therapeutic use*; D014527:Uric Acid / Q000097:blood*
chemical_list: D006016:Glycolates; D006852:Hydrochlorothiazide; D014527:Uric Acid; D005665:Furosemide; D003404:Creatinine; D013989:Ticrynafen
vernacular_title: Acide tiénilique, hyperuricémie et fonction rénale.