title: Gene for neuraminidase activity on mouse chromosome 17 near h-2: pleiotropic effects on multiple hydrolases.
abstract: The low activity of liver neuraminidase that is characteristic of mouse strain SM/J is inherited as a single gene on chromosome 17, near the major histocompatibility complex. This gene, neuraminidase-1 (Neu-1), is represented by the low activity allele Neu-1s in SM/J and the high activity allele Neu-1b in C57BL/6J and most other strains. Previously described variations in the posttranslational processing of acid phosphatase, alpha-mannosidase, arylsulfatase-B, and alpha-glucosidase are attributed to pleiotropic effects of this gene.
mesh_terms: D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D005260:Female; D006183:H-2 Antigens / Q000235:genetics; D006867:Hydrolases / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics* / Q000378:metabolism; D009439:Neuraminidase / Q000235:genetics*; D011498:Protein Precursors / Q000378:metabolism*; D011995:Recombination, Genetic; D012794:Sialic Acids / Q000378:metabolism
chemical_list: D006183:H-2 Antigens; D011498:Protein Precursors; D012794:Sialic Acids; D006867:Hydrolases; D009439:Neuraminidase