Differences in frequency of cleft lip among the A strains of mice.
The frequency of spontaneous cleft lip on Day 14 of gestation was examined in the A/J, A/HeJ, A/WySn, A.BY/Sn, A.SW/Sn, B10.A/SgSn, and B10.A(2R)/SgSn inbred strains of mice. A/WySn was found to have a higher frequency of cleft lip (20-30%) than A/J or A/HeJ (10%). Differences among strains in laterality of clefting and in rates of differential mortality of affected embryos were also found. Results of crosses between A/WySn and A/HeJ suggested that the difference in rate of clefting may be due to a genetic maternal effect. The results for A.BY/Sn, A.SW/Sn, B10.A/SgSn and B10.A(2R)/SgSn indicated that no association of cleft lip liability and the H-2 complex was detectable.
D000818:Animals; D002971:Cleft Lip / Q000235:genetics* / Q000473:pathology; D005260:Female; D005313:Fetal Death; D005865:Gestational Age; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D011247:Pregnancy