A pigmented mycelial antibiotic in Streptomyces coelicolor: control by a chromosomal gene cluster.
Streptomyces coelicolor was found to produce a third secondary metabolite, in addition to the antibiotics methylenomycin A and actinorhodin previously described. This is a red pigmented, highly non-polar compound with antibiotic activity against certain Gram-positive bacteria. Mutants lacking the red compound fell into five cosynthetic classes. Representatives of each of the five classes were mapped to the chromosome of the producing organism, in a closely linked cluster. Genetic studies provided evidence that this new metabolite is distinct from actinorhodin and indicated that the two pigments do not share parts of the same biosynthetic pathway.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001407:Bacillus / Q000187:drug effects; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005809:Genes, Regulator; D008040:Genetic Linkage; D009154:Mutation; D010641:Phenotype; D010860:Pigments, Biological / Q000096:biosynthesis; D011995:Recombination, Genetic; D013302:Streptomyces / Q000235:genetics* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D010860:Pigments, Biological