[Hypophosphoremic osteomalacia secondary to benign connective tissue tumors: a report on three unusual cases with vitamin D metabolites measurements (author's transl)].
Three cases of benign connective tissue tumors (intracranial frontal hemangiopericytoma, rectosigmoid hemangioma, intraspinal neurinoma) associated with hypophosphoremic osteomalacia and reduction in plasma 1-25 (OH)2D levels are described. Rapid reversal of biological anomalies and subsequent recovery from clinical manifestations were observed after tumor ablation. Twenty-two identical cases have been reported in the published literature. The sharp- fall in 1-25 (OH)2D levels without secondary hypocalcemia or hyperparathyroidism suggests that intestinal absorption of calcium is not entirely dependent on this metabolite. Increased phosphoremia without a parallel rise in 1-25 (OH)2D levels was noted in one case. The possibility of an existing connective tissue tumor should be explored in all cases of hypophosphoremic osteomalacia.
D000328:Adult; D000368:Aged; D003240:Connective Tissue Diseases / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000150:complications / Q000378:metabolism / Q000601:surgery; D010018:Osteomalacia / Q000097:blood / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D010758:Phosphorus / Q000097:blood*; D014807:Vitamin D / Q000378:metabolism*
D014807:Vitamin D; D010758:Phosphorus
Ostéomalacies hypophosphorémiques guéries par l'ablation de tumeurs bénignes du tissue conjonctif: étude de trois observations avec dosages pré- et post-opérations des métabolites de la vitamine D.