Synovial fluid hydroxyproline fractions before and after osmic acid treatment in rheumatoid arthritis.
Synovial fluid total, dialysable and non-dialysable hydroxyproline were determined in patients with Rheumatoid Arthritis before intra-articular osmic acid injection and on days 2 and 4 after this local treatment. On day 2 the increase in dialysable hydroxyproline paralleled the increase in non-dialysable hydroxyproline. Patients with the highest pre-treatment dialysable hydroxyproline levels also had the highest levels of this fraction on day 2 suggesting that articular damage proceeds after osmic acid injection. However, on day 4 dialysable hydroxyproline levels were consistently lower than before the treatment; the same pattern was observed with non-dialysable hydroxyproline, except for all the joints but one, where effusion recurred 6-12 months after osmic acid treatment. This study suggests that the determination of synovial fluid non-dialysable levels 4 days after osmic acid injection may provide a clue to the prediction of recurrent joint effusion and possibly justify a complementary injection either with osmic acid or with a beta-emitting isotope.
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006909:Hydroxyproline / Q000378:metabolism*; D007270:Injections, Intra-Articular; D008297:Male; D009992:Osmium / Q000627:therapeutic use*; D009993:Osmium Tetroxide / Q000627:therapeutic use*; D012008:Recurrence; D013582:Synovial Fluid / Q000187:drug effects / Q000378:metabolism*
D009992:Osmium; D009993:Osmium Tetroxide; D006909:Hydroxyproline