Pharmacokinetics of buflomedil after intravenous and oral administration.
Pharmacokinetics studies were conducted in 4 patients who received buflomedil 100 mg intravenously and in 3 volunteers who received buflomedil 450 mg per os. Buflomedil concentrations were determined by a gas liquid chromatography method. Buflomedil levels declined multiphasically with a mean clearance after intravenous administration of -0,034 (1 h-1 kg-1). The decline appeared to be monophasic after oral administration. In both cases the overall half-life is short, mean 2.07 hrs (range, 1,47-2,6 hrs).
D000284:Administration, Oral; D000328:Adult; D002090:Butyrophenones / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008657:Metabolic Clearance Rate; D011759:Pyrrolidines / Q000008:administration & dosage / Q000378:metabolism*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000378:metabolism*
D002090:Butyrophenones; D011759:Pyrrolidines; D014665:Vasodilator Agents; C010651:buflomedil