Utilization of N-acetyl-L-tryptophan given intravenously to unrestrained adult rats.
The nutritional value of N-acetyl-L-tryptophan (NALT) given intravenously was examined in unrestrained adult rats. They were given solutions of 4% Vuj pattern amino acids, 24.5% glucose, vitamins and electrolytes intravenously for 10 days. They were divided into three groups; one group was then injected intravenously with complete amino acid solution (T group), one with tryptophan-free amino acid solution (TF group) and one group with complete amino acid solution but with NALT instead of tryptophan (NALT). The biological value of the NALT group was 49.6; this value corresponded to 90% of that of the T group. Excretion of injected amino acids totalled about 2.0 to 3.0% in this experiment. The effects of NALT on carcass composition, certain blood constituents and tryptophan pyrrolase activity in the liver were also examined.
D000273:Adipose Tissue / Q000378:metabolism; D000596:Amino Acids / Q000652:urine; D000818:Animals; D007275:Injections, Intravenous; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D051381:Rats; D014364:Tryptophan / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D014366:Tryptophan Oxygenase / Q000096:biosynthesis
D000596:Amino Acids; C006392:N-acetyltryptophan; D014364:Tryptophan; D014366:Tryptophan Oxygenase; D009584:Nitrogen