[Variability of the dose effect in the radio-biologic experimentation on animals. Second communication: influence of breed, sex, age as well as of infections on death rates and LD 50 values (author's transl)].
As already demonstrated for Wistar rats, the radioresistance of Siv-50 male and female rats increases continually during their first months of life. Furthermore, males show a higher radioresistance than females during this period. The authors show with the same animals that a very radiosensitive rat strain can become a highly radioresistant strain after 2 1/2 years. After whole-body irradiation with 800--900 R, the increase of resistance of 85 days old males was between 62% and 68%. As a cause of this resistance increase, a mixed infection with Bordetella bronchiseptica and other germs is discussed. On the basis of literature, the authors discuss the occurrence of radioresistance increases after immunization or preconditioning with various bacterial vaccines and bacterial endotoxins.
D000367:Age Factors; D000818:Animals; D001424:Bacterial Infections / Q000150:complications; D001885:Bordetella Infections / Q000150:complications; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D011829:Radiation Dosage; D011836:Radiation Tolerance; D051381:Rats; D012737:Sex Factors
Zur Variabilität des Dosiseffektes im strahlenbiologischen Tierversuch. 2. Mitteilung: Einflüsse von Rasse, Geschlecht, Alter sowie von Infektionen auf die Absterberaten und die LD-50-Werte.