title: [Debatable questions of strophanthin and spironolactone treatment in certain forms of acute myocardial infarct].
abstract: The results of clinical and instrumental examination of 67 patients and experimental findings provide evidence of myocardial resistance to cardiac glycosides in acute myocardial infarction complicated by the initial stage of cardiac insufficiency. It is suggested that symptoms of secondary hyperaldosteronism may develop in acute myocardial infarction and that medication with cardiac glycosides in combination with spironolactones is expedient.
mesh_terms: D000328:Adult; D000818:Animals; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D011817:Rabbits; D013148:Spironolactone / Q000008:administration & dosage*; D013328:Strophanthins / Q000008:administration & dosage*; D013610:Tachycardia / Q000188:drug therapy; D013997:Time Factors
chemical_list: D013328:Strophanthins; D013148:Spironolactone
vernacular_title: Spornye voprosyu lecheniia strofantinom i spironolaktonami bol'nykh s nekotorymi formami ostrogo infarkta miokarda.