Choleresis and bile pigment excretion in the nutria.
Mean excretory rates of endogenous biliverdin (BV) and bilirubin (BR) in nutria were determined to be 6.0 +/- 1.0 and 0.67 +/- 0.10 microgram/min/kg, respectively. Endogenous bile flow was 33 +/- 7.0 microliter/min/kg. Infusion of sodium taurocholate at rates above 0.1 mumol/min/kg resulted in cholestasis. Hepatic transport maxima for BR conjugates following the infusion of unconjugated BR were 120 and 130 micrograms/min/kg. Although nutria excrete predominantly BV like avian and reptilian species, they differ by readily excreting an exogenous load of unconjugated BR.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001654:Bile Pigments / Q000378:metabolism*; D001663:Bilirubin / Q000378:metabolism; D001664:Biliverdine / Q000378:metabolism; D004896:Erythritol / Q000097:blood; D005260:Female; D008297:Male; D012377:Rodentia / Q000378:metabolism*; D013656:Taurocholic Acid / Q000494:pharmacology
D001654:Bile Pigments; D013656:Taurocholic Acid; D001664:Biliverdine; D004896:Erythritol; D001663:Bilirubin