Nonnarcotic antidiarrheal action of clonidine and lofexidine in the rat.
Clonidine (0.01 to 0.16 mg/kg) and lofexidine (0.01 to 0.64 mg/kg) produced a dose-dependent inhibition of diarrhea induced by castor oil treatment in the rat. Both drugs were more potent and longer acting than diphenoxylate. Pre- and posttreatment with naloxone (5 mg/kg) failed to prevent or antagonize the antidiarrheal effect of clonidine and lofexidine. These data suggest that clonidine and lofexidine may provide potent antidiarrheal activity of a nonnarcotic nature.
D000818:Animals; D000930:Antidiarrheals; D003000:Clonidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D003967:Diarrhea / Q000188:drug therapy*; D008297:Male; D009294:Narcotics; D051381:Rats
D000930:Antidiarrheals; D009294:Narcotics; D003000:Clonidine; C025655:lofexidine