title: [Selective inhibition of type A monoamine oxidase by pyrazidol].
abstract: Effect of a new antidepressant pyrazidol (1,10-trimethylene-8-methyl-1,2,3,4-tetrahydropyrazino /1,2-/ indole) on the liver and brain MAO activity of rats was studied in experiments in vivo and in vitro. Pyrazidol selectively blocks type A MAO (the substrates serotonin and noradrenaline) and does not virtually affect or has a far less action on type B MAO (the substrate 2-phenylethylamine).
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology; D002227:Carbazoles / Q000494:pharmacology*; D003641:Deamination; D004298:Dopamine / Q000378:metabolism; D066298:In Vitro Techniques; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology; D008996:Monoamine Oxidase Inhibitors; D009638:Norepinephrine / Q000378:metabolism; D010627:Phenethylamines / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013379:Substrate Specificity; D014439:Tyramine / Q000378:metabolism
chemical_list: D002227:Carbazoles; D007527:Isoenzymes; D008996:Monoamine Oxidase Inhibitors; D010627:Phenethylamines; D012701:Serotonin; C009830:pirlindole; D004298:Dopamine; D009638:Norepinephrine; D014439:Tyramine
vernacular_title: Izbiratel'noe ingibirovanie pirazidolom monoaminoksidazy tipa A.