title: Severe combined immunodeficiency associated with hyperimmunoglobulinaemia E, eosinophilia and impaired neutrophil chemotaxis.
abstract: A boy with severe combined immunodeficiency was found to have coexistent hyperimmunoglobulinaemia E, eosinophilia and impaired neutrophil chemotaxis. Based on the literature, a deficient regulatory function of the T-cell system is proposed as the basic defect leading to the observed impairment of the cellular and humoral immunity and, probably through hyper-immunoglobulinaemia E, to defective neutrophil chemotaxis.
mesh_terms: D002634:Chemotaxis, Leukocyte; D004802:Eosinophilia / Q000150:complications*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D007073:Immunoglobulin E; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007223:Infant; D008297:Male; D009504:Neutrophils
chemical_list: D007073:Immunoglobulin E