Albumin messenger RNA after partial hepatectomy and sham operation.
Albumin mRNA was quantified in nuclear RNA and in polysomal and post-polysomal poly(A)-containing RNA from untreated, hepatectomized and laparotomized rat livers. A prominent reduction of albumin-specific RNA sequences was observed in all subcellular fractions 50 h after partial hepatectomy, compared to both untreated and sham-operated livers. Surprisingly, laparotomy itself also induced a dilution of albumin-specific sequences at earlier times after operation in nuclei and in post-polysomal supernatant, but not in polysomes.
D000418:Albumins / Q000096:biosynthesis*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D006498:Hepatectomy; D008099:Liver / Q000378:metabolism*; D011132:Polyribosomes / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D013347:Subcellular Fractions / Q000378:metabolism; D013997:Time Factors; D014158:Transcription, Genetic
D000418:Albumins; D012333:RNA, Messenger