A general QSAR for dihydrofolate reductase inhibition by 2,4-diaminotriazines based upon molecular shape analysis.
D000818:Animals; D002417:Cattle; D005493:Folic Acid Antagonists; D008099:Liver / Q000201:enzymology; D008954:Models, Biological; D008958:Models, Molecular; D009374:Neoplasms, Experimental / Q000201:enzymology; D051381:Rats; D013329:Structure-Activity Relationship; D014227:Triazines / Q000494:pharmacology*
D005493:Folic Acid Antagonists; D014227:Triazines