Effects of inhibiting prolactin secretion on the maintenance of embryonic diapause in the suckling rat.
Treatment of rats with bromocriptine between days 5 and 8 after the post-partum mating resulted in suppression of serum prolactin levels and caused luteal regression. Although this treatment led to embryonic resorption when suckling was prevented by removing litters soon after birth, the diapausing embryos of animals nursing a litter of eight pups were unaffected by the treatment. These results suggest that the high levels of prolactin and progesterone in the circulation during lactation are not responsible for maintenance of the diapausing state.
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D003338:Corpus Luteum / Q000187:drug effects; D003864:Depression, Chemical; D010064:Embryo Implantation / Q000187:drug effects; D004622:Embryo, Mammalian / Q000502:physiology*; D005260:Female; D007774:Lactation; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011374:Progesterone / Q000494:pharmacology; D011388:Prolactin / Q000378:metabolism*; D051381:Rats
D001971:Bromocriptine; D011374:Progesterone; D011388:Prolactin