Effects of D-penicillamine on some oxidative enzymes of rat organs in vivo.
In the liver of neonate rats and in tissues of adult rats a study was made of the effect of D-penicillamine treatment in vivo on the enzymes of peroxide metabolism, lipid peroxidation and other components. It was found that D-penicillamine primarily acts by decreasing lipid peroxidation, thus stabilizing the membrane.
D000375:Aging; D000818:Animals; D002374:Catalase / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D010396:Penicillamine / Q000494:pharmacology*; D010544:Peroxidases / Q000378:metabolism*; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism*; D014018:Tissue Distribution
D003577:Cytochrome P-450 Enzyme System; D010544:Peroxidases; D002374:Catalase; D013482:Superoxide Dismutase; D010396:Penicillamine