[Radiation block of mitoses and the action of stimulating factors].
Using the HeLa cell culture, the dynamics of the appearance of the mitotic block after irradiation with 600 rads has been studied, in addition to the influence of some proliferating stimulatory factors on this process. It has been shown that in the early periods after irradiation with 600 rads, on the background of the developing G2--M block, the low dose irradiation (20 rads), changes to the medium, and high temperature (41--42 degrees C) effects lead to the increase in the number of mitoses. It is supposed that this increase in the mitotic activity may be due to a heterogeneity of cell populations as to their velocity of passing through the G2-phase.
D003470:Culture Media / Q000494:pharmacology; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006367:HeLa Cells / Q000528:radiation effects; D006801:Humans; D066298:In Vitro Techniques; D007399:Interphase / Q000528:radiation effects; D008938:Mitosis / Q000528:radiation effects*; D013696:Temperature; D013997:Time Factors
D003470:Culture Media
Radiatsionnyĭ blok mitozov i deĭstvie stimuliruiushchikh faktorov.