Buformin concentrations in a case of fatal lactic acidosis.
A fatal case of lactic acidosis in a 84 year old diabetic woman taking buformin is reported. Buformin concentrations in serum, other body fluids and tissues were measured by gas chromatography. Serum buformin concentration at admission was 5.5 mg/l. Postmortem concentrations were: in serum 3.2 mg/l; in lung 2.8 mg/kg wet weight; in heart 3.0 mg/kg; in pericardial fluid 3.5 mg/l; in liver 5.2 mg/kg; in bile 6.3 mg/l; and in kidney 98 mg/kg.
D000138:Acidosis / Q000139:chemically induced*; D000368:Aged; D001645:Biguanides / Q000506:poisoning*; D002026:Buformin / Q000097:blood / Q000506:poisoning*; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D007773:Lactates; D014018:Tissue Distribution
D001645:Biguanides; D007773:Lactates; D002026:Buformin