Selective transient suppression of globin chain synthesis by blood transfusions in beta-thalassemia.
Thalassemias are characterized by an imbalance in globin chain synthesis. When patients having beta-thalassemia major are given transfusions, globin synthesis is transiently suppressed, particularly the alpha chains. This results in a relatively improved alpha/beta ration that may erroneously be interpreted as indicating stimulation of beta chain synthesis.
D000293:Adolescent; D001803:Blood Transfusion; D002648:Child; D002845:Chromatography / Q000379:methods; D005260:Female; D005914:Globins / Q000096:biosynthesis*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D013789:Thalassemia / Q000097:blood* / Q000628:therapy
D006454:Hemoglobins; D005914:Globins