Electron microscopic demonstration of adenylate cyclase activity in rat cortical synaptosomes.
The electron cytochemical demonstration of adenylate cyclase activity was carried out in rat cortical synaptosomes. Reaction product was found in 60-70% of the synaptosomes in three predominant localization: (i) on the postsynaptic density; (ii) on the outer aspect of the synaptosomal membrane; (iii) inside the synaptosome. Results suggest that in addition to postsynaptic localization adenylate cyclase activity is cytochemically demonstrable also at presynaptic sites.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000201:enzymology*; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D013574:Synaptosomes / Q000201:enzymology*
D000262:Adenylyl Cyclases