[Biosynthesis of cholesterol and formation of cholesta-4-dien-3-one in stomach and intestine of rats with experimental D-hypovitaminosis].
Inhibition of cholesterol biosynthesis with D-hypovitaminosis is shown to occur in the secretary and esophageal regions of the stomach, mucose and serous membranes of small intestine at the stages of methylsterol demelthylation and transformation of lathosterol into 7-dehydrocholesterol. With this pathology under study there occurs considerable increase in the content of the 7-dehydrocholesterol oxidation product--cholesta-4,7-dien-3-one in the above-mentioned tissues. A problem on possible inhibition of cholesterol biosynthesis with D-hypovitaminosis by this oxycompound is under discussion.
D000818:Animals; D002783:Cholestenones / Q000378:metabolism; D002784:Cholesterol / Q000096:biosynthesis* / Q000378:metabolism; D003684:Dehydrocholesterols / Q000378:metabolism; D004947:Esophagus / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D014808:Vitamin D Deficiency / Q000378:metabolism*
D002783:Cholestenones; D003684:Dehydrocholesterols; C019301:cholesta-4,7-dien-3-one; C001521:lathosterol; D002784:Cholesterol; C016705:7-dehydrocholesterol
Biosintez kholesterina i obrazovanie kholesta-4, 7-dien-3-ona v tkaniakh zheludka i kishechnika krys pri eksperimental'nom D-gipovitaminoze.