Necrotizing effects of kainic acid on neurons in the pigeon brain: histological observations.
The neurotoxin kainic acid (KA) has been shown to destroy neurons in the pigeon paleostriatal complex (PC), the avian analogue of the caudato-putamen and globus pallidus. In this earlier study the movement disorders in pigeons were strikingly similar to those reported by others in rats following intracerebral injection of KA into the corpus striatum. The toxic influences of KA on other parts of the pigeon brain have not been described. Therefore, KA was injected into areas of the telencephalon, diencephalon, mesencephalon and cerebellum. Areas sensitive to KA showed a marked cell loss and the neuropil exhibited spaces that contained fragments of necrotic neurons. The injection sites were invaded by glia and granulocytes. Kainic acid had a local necrotizing effect; for example, it destroys neurons in the PC, nucleus rotundus, nucleus spiriformis lateralis, nucleus ruber and neurons of the cerebellar cortex. An apparent long-distance effect of KA was also observed, since intracerebral injections of KA into the PC was followed by cell loss in the ipsilateral nucleus of the ansa lenticularis. Kainic acid has proved to be a potent neurotoxin with a pronounced necrotizing effect upon neurons in the pigeon brain.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D002531:Cerebellum / Q000187:drug effects; D010856:Columbidae; D003342:Corpus Striatum / Q000187:drug effects; D004027:Diencephalon / Q000187:drug effects; D004292:Dominance, Cerebral / Q000187:drug effects; D007608:Kainic Acid / Q000633:toxicity*; D008636:Mesencephalon / Q000187:drug effects; D009336:Necrosis; D009474:Neurons / Q000187:drug effects; D011759:Pyrrolidines / Q000633:toxicity*; D013687:Telencephalon / Q000187:drug effects
D011759:Pyrrolidines; D007608:Kainic Acid