[Sensitization study of oncological patients to bacterial allergens with the aid of the leukocyte migration inhibition reaction].
The results of studying sensitization of 88 patients with cancer (larynx, esophagus, ovaries) to 7 bacterial allergens (pathogenic and nonpathogenic staphylococcus, hemolytic streptococcus, catarrhal diplococcus, Proteus, Escherichia coli and blue pus bacilli) are reported. These bacilli are most frequently the cause of development of postoperative suppurations. The studies performed (before, during and after the combined therapy) indicated by leucocyte migration inhibition test that during the disease ad therapeutic course there occurs nonspecific sensitization of leucocytes to bacterial allergens which gradually disappears following termination of the therapy. Postoperatively, the sensitization offers grounds for the development of suppurative complications, the latter is associated with the enhanced inhibition of leucocytes migration by an allergen of that microbial species which caused the development of suppurative complications. Therefore, this test with a set of bacterial allergens may be used as a diagnostic adjunct early reveal the postoperative suppurations.
D000485:Allergens / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology*; D002464:Cell Migration Inhibition; D004938:Esophageal Neoplasms / Q000276:immunology*; D005260:Female; D006801:Humans; D007114:Immunization; D007822:Laryngeal Neoplasms / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology*; D010051:Ovarian Neoplasms / Q000276:immunology*; D011183:Postoperative Complications / Q000209:etiology
D000485:Allergens; D000942:Antigens, Bacterial
Izuchenie sensibilizatsii onkologicheskikh bol'nykh k bakterial'nym allergenam s pomoshch'iu reaktsii tormozheniia migratsii leĭkotsitov.