Correlation between serotonin uptake and imipramine binding in schizophrenic patients.
1. The active uptake of serotonin by platelets of schizophrenic patients and a healthy control group was compared with imipramine binding to these platelets. 2. Significant correlation was observed between the Vmax of serotonin uptake and the imipramine binding. 3. Serotonin uptake by patients was much lower than that of control group.
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins; D005260:Female; D006801:Humans; D007099:Imipramine / Q000097:blood*; D007700:Kinetics; D008297:Male; D011955:Receptors, Drug / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism; D012559:Schizophrenia / Q000097:blood*; D012701:Serotonin / Q000378:metabolism*
D002352:Carrier Proteins; D011955:Receptors, Drug; D011985:Receptors, Serotonin; C027775:imipramine receptor; D012701:Serotonin; D007099:Imipramine