Tetrahydro-2-benzoxepins: a novel family of hypotensives.
A novel series of 1-(alkylamino)-1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepins shows hypotensive activity. A typical example is 1-[2-(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepin-1-yl)ethyl]-4-(4-fluorophenyl)piperazine. This compound is an alpha blocker with peripheral and central activities.
D000758:Anesthesia; D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D001584:Benzoxepins / Q000138:chemical synthesis* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D055598:Chemical Phenomena; D002621:Chemistry; D003714:Denervation; D004285:Dogs; D005260:Female; D008297:Male; D011311:Pressoreceptors / Q000502:physiology; D051381:Rats; D013997:Time Factors
D000959:Antihypertensive Agents; D001584:Benzoxepins