title: [DNA repair in xeroderma pigmentosum].
abstract: DNA-repair of two patients affected with xeroderma pigmentosum was evaluated in lymphocytes after UV-exposure by mitotic index, sister chromatid exchange (SCE) and nucleoid sedimentation. The first patient showed no increase in SCE-rate and a sedimentation profile typical of repair deficient cells. In the second patient an increase in SCE-rate and a considerable, but delayed DNA-repair activity in nucleoid sedimentation was found indicating 2 genetically different defects of DNA-repair. In the second patient a defect of postreplication repair is assumed.
mesh_terms: D002648:Child; D004260:DNA Repair / Q000528:radiation effects; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects; D008297:Male; D008940:Mitotic Index; D011379:Prognosis; D014466:Ultraviolet Rays / Q000009:adverse effects; D014983:Xeroderma Pigmentosum / Q000378:metabolism*
vernacular_title: DNA-Reparatur bei Xeroderma pigmentosum.