Angiotensin II in the hippocampus. A histochemical and electrophysiological study.
The presence of the renin angiotensin system in the hippocampus is shown by immunohistochemistry. Intra- and extra-cellular recordings revealed that angiotensin II and III excite CA 1 pyramidal cells by disinhibition. The effect is antagonized by [Sar1, Thr8]-A II.
D000200:Action Potentials / Q000187:drug effects; D000804:Angiotensin II / Q000378:metabolism* / Q000494:pharmacology; D000805:Angiotensin III / Q000494:pharmacology; D000818:Animals; D006624:Hippocampus / Q000378:metabolism*; D009433:Neural Inhibition / Q000187:drug effects; D051381:Rats; D012504:Saralasin / Q000494:pharmacology
D000804:Angiotensin II; D000805:Angiotensin III; D012504:Saralasin