Lack of efficacy of 2-deoxy-D-glucose in the treatment of experimental herpes genitalis in guinea pigs.
Topical treatment of herpes genitalis in female guinea pigs with 2-deoxy-D-glucose in either agarose gels or miconazole nitrate ointments failed to prevent the development of genital lesions or to reduce the mean titers of recoverable virus in vaginal swabs from infected animals. In contrast, phosphonoacetic acid was therapeutically effective.
D000287:Administration, Topical; D000818:Animals; D003837:Deoxy Sugars / Q000627:therapeutic use*; D003847:Deoxyglucose / Q000627:therapeutic use*; D005260:Female; D006168:Guinea Pigs; D006558:Herpes Genitalis / Q000188:drug therapy*; D008297:Male; D008825:Miconazole / Q000627:therapeutic use; D010746:Phosphonoacetic Acid / Q000627:therapeutic use; D013997:Time Factors
D003837:Deoxy Sugars; D008825:Miconazole; D003847:Deoxyglucose; D010746:Phosphonoacetic Acid