Dapsone-responsive, noninfectious verrucous pyoderma. Its occurrence following cisplatin therapy.
A nodular, centrally verrucous, noninfectious pyoderma of the dorsal aspects of the hands and fingers developed in a 66-year-old man with metastatic bladder carcinoma after palliative cisplatin therapy. The dermatosis was clinically similar to erythema elevatum diutinum but biopsy failed to show substantial leukocytoclastic vasculitis. The eruption responded to dapsone. The role of cisplatin in the induction of the dermatosis is speculative.
D000368:Aged; D002945:Cisplatin / Q000009:adverse effects*; D003622:Dapsone / Q000627:therapeutic use*; D006229:Hand Dermatoses / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011711:Pyoderma / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy
D003622:Dapsone; D002945:Cisplatin