Expression of mosaicism in females heterozygous for Jimpy.
The Jimpy mouse is a sex-linked neurological mutant characterized by a paucity of myelin in the central nervous system (CNS). The distribution of myelin in the optic nerves of female carriers of the Jimpy gene exhibits a mosaic pattern such that patches of tissue along the nerve are identical in appearance to the hemizygote male, while other areas appear normal.
D000367:Age Factors; D000818:Animals; D005260:Female; D006579:Heterozygote; D008297:Male; D051379:Mice; D008816:Mice, Jimpy; D008854:Microscopy, Electron; D009030:Mosaicism; D009186:Myelin Sheath / Q000648:ultrastructure*; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure; D009900:Optic Nerve / Q000033:anatomy & histology*