Physico-chemical, mutagenic and carcinogenic properties of nitrosated urea herbicide metabolites.
Alkylating activities, rates of decomposition, partition coefficients (octanol/water) and sister chromatid exchanges of several N-nitroso compounds, formed by nitrosation of pesticide metabolites or closely related substances, were determined. The carcinogenic activity of two compounds was investigated in rats. The measured parameters were compared in a search for possible correlations.
D000818:Animals; D002273:Carcinogens; D055598:Chemical Phenomena; D002621:Chemistry; D006207:Half-Life; D006540:Herbicides / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D009153:Mutagens; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
D002273:Carcinogens; D006540:Herbicides; D009153:Mutagens; D009607:Nitrosourea Compounds