Albumin extravasation in bicuculline-induced blood-brain barrier dysfunction. A comparison between endogeneous and 125I-labeled exogeneous serum albumin.
The extravasation of endogeneous rat albumin and exogeneous 125I-labeled human serum albumin was compared in rats subjected to bicuculline-induced blood-brain barrier dysfunction. The correlation between rocket immunoelectrophoretic assays of endogeneous rat albumin and 125I-labeled human serum albumin, assayed by gamma scintillation counting, was good respective of whether 125I-labeled albumin was studies in whole brain tissue or in brain homogenates. The ratio of brain to serum albumin was similar with the two assay methods.
D000418:Albumins / Q000032:analysis; D000818:Animals; D001640:Bicuculline; D001812:Blood-Brain Barrier; D001923:Brain Chemistry; D001932:Brain Neoplasms / Q000139:chemically induced; D007122:Immunoelectrophoresis / Q000379:methods; D008297:Male; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism*; D012711:Serum Albumin, Radio-Iodinated
D000418:Albumins; D012709:Serum Albumin; D012711:Serum Albumin, Radio-Iodinated; D001640:Bicuculline