A clinical study on the prolonged antihypertensive effect of clonidine in a sustained-release capsule formulation.
Eight patients with essential hypertension each received a single oral dose of 1 capsule of a sustained-release formulation of 0.25 mg clonidine in the morning for 3 consecutive days. Pulse ratio and blood pressure were measured in the standing and supine positions at specific intervals. After the first day of treatment, a significant decrease in blood pressure lasting 24 hours was recorded for the standing position. In the supine position, there was a progressive decrease in blood pressure which also attained significance on the third day of treatment. There was a progressive and significant reduction in mean arterial pressure from the first to the third day.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002214:Capsules; D003000:Clonidine / Q000008:administration & dosage* / Q000494:pharmacology; D003692:Delayed-Action Preparations; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011187:Posture
D002214:Capsules; D003692:Delayed-Action Preparations; D003000:Clonidine