title: Influence of an antiarrhythmic premedication on the development of premature ventricular contractions during fiberoptic gastroduodenoscopy.
abstract: Heart rate, blood pressure and ECG changes during fiberoptic gastroscopy were examined in 128 patients, 60 of whom had been orally premedicated with Mexiletine. 55% of the non-premedicated patients developed occasional, and 22% of this group developed accumulated or frequent, premature ventricular contractions. In the patient group with antiarrhythmic premedication, the respective figures were 25% and 8%, and in this group patients with a normal ECG developed premature ventricular contractions less frequently than patients with pathological changes in the ST segment. The antiarrhythmic premedication had no influence on pulse or blood pressure.
mesh_terms: D001145:Arrhythmias, Cardiac / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D001794:Blood Pressure; D004384:Duodenoscopy / Q000009:adverse effects*; D004562:Electrocardiography; D005773:Gastroscopy / Q000009:adverse effects*; D006352:Heart Ventricles; D006801:Humans; D008801:Mexiletine / Q000627:therapeutic use*; D008875:Middle Aged; D011292:Premedication; D011437:Propylamines / Q000627:therapeutic use*; D011674:Pulse
chemical_list: D011437:Propylamines; D008801:Mexiletine