Administration o gentamicin to obese patients.
The relation beteen a single bolus dose of gentamicin and the subsequent concentration in serum was studied in 17 obese patients with 82.7% excess weight and in 10 normal-weight patients. The apparent volume of distribution (AVD) for gentamicin in the two groups was calculated. In the obese group the AVD (17.7%) was found to be significantly lower than in the normal-weight group (23.2%). The AVD for the adipose tissue and the lean body mass was calculated to be 10.3% and 31.0%, respectively. The uptake of gentamicin in adipose tissue was found to be 43.7% of the uptake in the total body mass of normal-weight patients. A formula which indicates an adjudged body weight is recommended when the proper dose of gentamicin for obese patients is calculated. The formula is recommended only in cases of severe obesity.
D000273:Adipose Tissue / Q000378:metabolism; D000368:Aged; D001835:Body Weight; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009765:Obesity / Q000378:metabolism*
D005839:Gentamicins