[Effect of nucleophilic compounds on sarcolysine-3H and DMNA-14C binding with DNA].
The authors have studied the effect of adenine, adenosine, guanosine, cytidine and cysteine on sarcolysine-3H binding to DNA in vivo (rat liver) an in vitro and DMNA-14C binding in vivo. It was shown that among the compounds under test adenine, adenosine and guanosine rendered a marked protective effect with relation to DNA alkylation, which is likely to be due to their nucleophilic properties.
D000818:Animals; D002250:Carbon Radioisotopes; D002417:Cattle; D002467:Cell Nucleus / Q000187:drug effects*; D004247:DNA / Q000378:metabolism*; D004128:Dimethylnitrosamine / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008558:Melphalan / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D014316:Tritium
D002250:Carbon Radioisotopes; D014316:Tritium; D004247:DNA; D004128:Dimethylnitrosamine; D008558:Melphalan
Vliianie nekotorykh nukleofil'nykh soedineniĭ na sviazyvanie sarkolizina-3H i DMNA-14C s DNK.