A rapid and specific method for measuring chloramphenicol degradation in aqueous solution following autoclaving.
An HPLC method is reported for the measurement of chloramphenicol and its degradation product following autoclaving. The procedure, using a reversed-phase column and potassium phosphate solution as the solvent, is shown to be suitable for monitoring chloramphenicol degradation in intrathecal injections after sterilisation.
D002701:Chloramphenicol / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D004356:Drug Storage; D013242:Sterilization; D013696:Temperature
D002701:Chloramphenicol