Phencyclidine produces aggressive behavior in rapid eye movement sleep-deprived rats.
This study examined effects of acute doses of phencyclidine (PCP; 0.025, 0.05, 0.10, and 0.20 mg/kg intraperitoneally) on intra-specific aggressive behavior and muricide in normal rats and rats deprived of rapid eye movement (REM) sleep. Dose-related changes in intra-specific aggression and muricide occurred in REM sleep-deprived rats only. Dose-response curves are inverted-U shaped with the .05 mg/kg dose producing increases in aggression. Intra-specific aggression and muricide may serve as models of PCP-induced aggression in humans.
D000374:Aggression; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D051379:Mice; D010622:Phencyclidine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012892:Sleep Deprivation / Q000502:physiology; D012895:Sleep, REM / Q000502:physiology; D019966:Substance-Related Disorders / Q000150:complications
D010622:Phencyclidine