Genetic control of experimental autoimmune myasthenia gravis in mice. II. Lymphocyte proliferative response to acetylcholine receptor is dependent on Lyt-1+23- cells.
The proliferative response of regional lymph node lymphocytes to Torpedo acetylcholine receptor (TAR) is under H-2 linked Ir gene control. In high responder B6 (H-2b) congenic mice, lymphocytes that proliferate in vitro in response to TAR are dependent on T cells of a subpopulation expressing the phenotype associated with helper functions, Lyt-1+23-.
D000109:Acetylcholine / Q000276:immunology; D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001327:Autoimmune Diseases / Q000235:genetics*; D007519:Isoantigens / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D009157:Myasthenia Gravis / Q000235:genetics*; D010641:Phenotype; D011817:Rabbits; D011950:Receptors, Cholinergic / Q000235:genetics*; D011978:Receptors, Nicotinic / Q000235:genetics*
D000961:Antilymphocyte Serum; D007519:Isoantigens; D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic; D000109:Acetylcholine