Effects of N-(2-mercaptopropionyl) glycine on neutrophil locomotion.
The effects of the sulphydryl group donor N-(2-mercaptopropionyl) glycine on neutrophil locomotion were evaluated in vitro. The drug, when used at a concentration of 10(-3) M was found to stimulate the random migration and chemotaxis of normal neutrophils as a result of an enhanced rate of locomotion. The true chemotactic response was unaffected. N-(2-mercaptopropionyl) glycine appeared to exert its effect on the whole moving cell population.
D000603:Amino Acids, Sulfur / Q000494:pharmacology*; D002364:Caseins / Q000494:pharmacology; D002465:Cell Movement / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D006801:Humans; D009504:Neutrophils / Q000187:drug effects*; D008625:Tiopronin / Q000494:pharmacology*
D000603:Amino Acids, Sulfur; D002364:Caseins; D008625:Tiopronin