title: Sulfatase activity of keratinizing tissues in X-linked ichthyosis.
abstract: Arylsulfatases A and B were measured in the stratum corneum of four normal controls and two individuals with sex-linked ichthyosis. For arylsulfatase A, the mean delta optical density/hr/mg protein value was 1.6 for controls and 2.0 for patients, whereas for arylsulfatase B values of 1.5 for controls and 1.4 for patients were observed. Assay of arylsulfatase C in the callus of four normal controls showed a mean delta optical density/hr/100 mg callus of 0.63, whereas no or trace activity was detected in callus from four patients with x-linked ichthyosis. The assay of steroid sulfatase is best for studying microsomal sulfatase activity. Table 1 shows the activity of this enzyme in nails, callus, and hair bulbs from controls and patients with x-linked ichthyosis. No steroid sulfatase could be demonstrated in patients with x-linked ichthyosis. The values in normal controls and obligate heterozygotes are compared in Table 2. The mean value of the two groups is statistically different with P less than or equal to 0.05 using the Student t test.
mesh_terms: D001192:Arylsulfatases / Q000172:deficiency / Q000378:metabolism*; D005260:Female; D008040:Genetic Linkage; D006197:Hair / Q000201:enzymology*; D006579:Heterozygote; D006801:Humans; D007057:Ichthyosis / Q000201:enzymology* / Q000235:genetics; D009262:Nails / Q000201:enzymology*; D012729:Sex Chromosome Aberrations / Q000235:genetics; D013429:Sulfatases / Q000378:metabolism*; D014960:X Chromosome
chemical_list: D013429:Sulfatases; D001192:Arylsulfatases