Altered hepatic microsomal metabolism of androstenedione as a function of age in mice.
The hepatic microsomal metabolism of androstenedione was examined in female Swiss Webster mice at ages 1, 3, 6, 9, 12, 15 and 18 months. 6 beta-Hydroxylase and 15 alpha-hydroxylase activities decreased with age while a corresponding increase in 7 alpha-hydroxylase activity occurred. Similar changes have been observed in streptozotocin-induced diabetic rats. Decreases in hepatic aryl hydrocarbon hydroxylase, 7-ethoxycoumarin O-dethylase and aniline hydroxylase with advanced age have also previously been reported for this strain of mouse. The ability to respond to certain hormones is altered during the aging process, and the altered hepatic metabolism of androgens may contribute to this effect.
D000375:Aging; D000735:Androstenedione / Q000378:metabolism*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D005260:Female; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism
D000735:Androstenedione; D006899:Mixed Function Oxygenases