title: Control of postoperative pain by interactive demand analgesia.
abstract: A demand analgesia apparatus is described. It communicates with the patient by means of spoken messages in any desired language, so that preliminary instruction is unnecessary. Dosage is limited by a reduction in respiratory rate, and by a series of electronic fail-safe circuits. Operation of the system is illustrated in a series of 10 patients given fentanyl "on demand" for the first 12 h after operation. The mean dose rate 0.73 +/- 0.49 microgram min-1. There was no evidence of cumulation or tolerance during the period of study.
mesh_terms: D000698:Analgesia / Q000295:instrumentation / Q000379:methods*; D004334:Drug Administration Schedule; D005283:Fentanyl / Q000008:administration & dosage; D006801:Humans; D008128:Logic; D010149:Postoperative Pain / Q000188:drug therapy*; D010349:Patient Compliance; D012119:Respiration; D013060:Speech
chemical_list: D005283:Fentanyl