Terminal hepatic failure following a small dose of sulfamethoxazole-trimethoprim.
Fatal hepatotoxicity is a known complication of sulfamethoxazole and sulfamethoxazole-trimethoprim. We report a case of a man previously exposed to sulfamethoxazole-trimethoprim who died of liver failure following subsequent ingestion of only two tablets of the drug (160 mg trimethoprim and 800 mg sulfamethoxazole). This case indicates the danger to a susceptible patient of even small (e.g., "rechallenge") doses of sulfamethoxazole.
D000368:Aged; D001201:Ascites / Q000139:chemically induced; D003951:Diagnostic Errors; D006505:Hepatitis / Q000175:diagnosis; D006801:Humans; D007565:Jaundice / Q000139:chemically induced; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000139:chemically induced*; D008297:Male; D013420:Sulfamethoxazole / Q000009:adverse effects*
D013420:Sulfamethoxazole