title: Vogt-Koyanagi-Harada syndrome with focal neurologic signs.
abstract: The Vogt-Koyanagi-Harada syndrome includes inflammation of the uveal tract, retina, and meninges. Integumentary and auditory signs are common. Neurologic involvement has been reported. We studied two patients who manifested many of the varied clinical signs of Vogt-Koyanagi-Harada syndrome, but who also showed focal neurologic involvement, including acute transverse myelitis and ciliary ganglionitis. Both patients responded well to corticosteroid therapy. The findings in these patients and the results of previous studies suggest that Vogt-Koyanagi-Harada syndrome is a cell-mediated autoimmune disorder in which a component of myelin acts as an inciting antigen.
mesh_terms: D000208:Acute Disease; D000328:Adult; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008266:Macula Lutea; D008297:Male; D009187:Myelitis / Q000175:diagnosis* / Q000188:drug therapy; D009460:Neurologic Examination; D012163:Retinal Detachment / Q000175:diagnosis; D012173:Retinitis / Q000175:diagnosis* / Q000188:drug therapy; D013577:Syndrome; D014605:Uveitis / Q000175:diagnosis* / Q000188:drug therapy; D014717:Vertigo / Q000175:diagnosis / Q000188:drug therapy