In vitro and in vivo release of microencapsulated chlorothiazide.
Microcapsules of chlorothiazide were prepared by the complex coacervate technique using gelatin and acacia as the wall-forming materials. The release of drug from the microcapsules and compressed tablets of microcapsules were studied in vitro and in vivo. In vitro dissolution was characterized by a rapid release of drug followed by a slower, more sustained release. The effects of pH and concentration are discussed. In vivo release of drug was determined from urine, and the volume of urine passed was studied.
D002214:Capsules; D002740:Chlorothiazide / Q000008:administration & dosage* / Q000378:metabolism; D004339:Drug Compounding; D006801:Humans; D006863:Hydrogen-Ion Concentration; D012995:Solubility; D013607:Tablets; D013997:Time Factors
D002214:Capsules; D013607:Tablets; D002740:Chlorothiazide