Effect of lead and zinc administration on liver, kidney and brain levels of copper, lead, manganese and zinc and on erythrocyte ALA-D activity in rats.
Albino male rats were given lead (Pb) and zinc (Zn) orally, singly or in combination, for 14 consecutive days. Liver Pb was increased and liver manganese (Mn) was decreased in animals receiving Pb. The combination of Pb and Zn led to increased Pb and decreased copper (Cu) and Mn. Kidney Zn was increased in rats given Zn or the combination of Pb and Zn. There were no changes in kidney Cu or Mn in any group. Brain Pb levels were significantly increased in animals given Pb and Zn levels in those given Zn. Erythrocytic amino levulinic acid dehydratase (ALA-D) activity was significantly decreased by Pb but not by Pb + Zn.
D000818:Animals; D001921:Brain / Q000187:drug effects; D003300:Copper / Q000378:metabolism; D004347:Drug Interactions; D007668:Kidney / Q000187:drug effects; D007854:Lead / Q000378:metabolism / Q000633:toxicity*; D008099:Liver / Q000187:drug effects; D008297:Male; D008345:Manganese / Q000378:metabolism; D008670:Metals / Q000378:metabolism*; D000623:Porphobilinogen Synthase / Q000097:blood*; D051381:Rats; D015032:Zinc / Q000378:metabolism / Q000633:toxicity*
D008670:Metals; D007854:Lead; D008345:Manganese; D003300:Copper; D000623:Porphobilinogen Synthase; D015032:Zinc