title: Local cerebral glucose utilization in the symptomatic thiamine-deficient rat: increases in fornix and pyramidal tract.
abstract: Local cerebral glucose utilization (LCGU) was measured in asymptomatic rats on a thiamine (B1)-deficient diet for 70 days and in symptomatic rats on a B1-deficient diet for 98 days. LCGU increased in postcommissural fornix (F), pyramidal tracts (P), and inferior internal capsule (CAI) of symptomatic, compared with asymptomatic B1-deficient rats but decreased in thalamic nuclei, auditory structures, and lesioned vestibular nuclei. B1 administration to symptomatic rats improved symptoms; decreased LCGU in F. P, and CAI; increased LCGU in the lesioned vestibular nuclei; but decreased LCGU in mammillary nuclei, anteroventral nucleus of thalamus, and medial raphe. The results indicate that B1 deficiency symptoms correlate with LCGU changes in F and P and vestibular nuclei.
mesh_terms: D000818:Animals; D001303:Auditory Cortex / Q000378:metabolism; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D011712:Pyramidal Tracts / Q000378:metabolism*; D051381:Rats; D013787:Thalamic Nuclei / Q000378:metabolism; D013832:Thiamine Deficiency / Q000378:metabolism*; D014726:Vestibular Nuclei / Q000378:metabolism
chemical_list: D005947:Glucose