The effect of steroidal and nonsteroidal anti-inflammatory agents on corneal re-epithelialization.
Topical 0.5% indomethacin, 0.01% flurbiprofen, 1% prednisolone acetate, 0.1% dexamethasone, or 0.1% fluorometholone pretreatment and daily instillation did not affect the course of re-epithelialization after partial corneal epithelial denudation. However, topical 1% prednisolone acetate, 0.1% dexamethasone, and 0.1% fluorometholone--but not 0.5% indomethacin and 0.01% flurbiprofen--significantly retarded re-epithelialization after complete corneal denudation.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003315:Cornea / Q000187:drug effects*; D003907:Dexamethasone / Q000494:pharmacology; D004848:Epithelium / Q000187:drug effects; D005469:Fluorometholone / Q000494:pharmacology; D005480:Flurbiprofen / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D011239:Prednisolone / Q000494:pharmacology; D011817:Rabbits
D000893:Anti-Inflammatory Agents; D005480:Flurbiprofen; D003907:Dexamethasone; D011239:Prednisolone; D005469:Fluorometholone; D007213:Indomethacin