[Inhibiting effect of phenformin (phenethyl biguanide) on the growth of Ehrlich carcinoma].
Phenformin was shown to inhibit the rate of the Ehrlich carcinoma cell growth both in solid and ascitic forms of the tumor. The effect of phenformin on the tumor was eliminated by a diet containing high level of fats. The supernatant from the 18-hour culture of splenic cells, obtained from carcinoma-bearing mice treated by phenformin, inhibited phagocytosis of normal macrophages to a less extent compared with tumor-bearing mice which were not given phenformin. A peritoneal exudate from these mice was less effective in suppressing normal macrophages adhesiveness compared with untreated tumor-bearing mice.
D000818:Animals; D000970:Antineoplastic Agents; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D003864:Depression, Chemical; D004353:Drug Evaluation, Preclinical; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D010629:Phenformin / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D010629:Phenformin
Tormoziashchee vliianie fenformina (fenitilbiguanida) na rost kartsinomy Erlikha.