In vitro inhibition of endometrial cancer growth by a neonatal rat testicular secretory product.
The ability of a neonatal testicular product to inhibit cancer cell line growth of Mullerian origin was tested in an "in vitro" system. Preliminary experiments indicated that increasing concentration of neonatal rat testicular homogenates showed increasing endometrial cancer (HEC-1) cell growth inhibition. Further investigation revealed that testes organ culture, similarly, inhibited HEC-1 cell growth. It is, therefore, concluded that neonatal rat testes elaborated a substance (or substances) which may be effective as an anti-tumor agent.
D000818:Animals; D000831:Animals, Newborn; D000970:Antineoplastic Agents; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D009924:Organ Culture Techniques; D029584:Prostatic Secretory Proteins; D011506:Proteins / Q000494:pharmacology*; D051381:Rats; D029589:Seminal Plasma Proteins; D013737:Testis / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000503:physiopathology*
D000970:Antineoplastic Agents; D029584:Prostatic Secretory Proteins; D011506:Proteins; D029589:Seminal Plasma Proteins; C043076:beta-microseminoprotein