Activation of natural killer (NK) cells in vivo with H-2 and non-H-2 alloantigens.
Intraperitoneal inoculation of allogeneic lymphoid cells rapidly activates cytotoxic cells in the peritoneum which are nonadherent and express the NK-1, asialo-GM1, and Thy-1 antigens. Allogeneic spleen cells were very efficient at activating these natural killer (NK) cells, while allogeneic thymocytes were much less effective. Heat-killed allogeneic cells or sonicates also could augment NK activity.--Incompatbility at H-2K, H-2T-A, or H-2D readily evoked NK cell activity, while H-2S- and H-2I-E/C-associated a disparities did not. Non-H-2 differences also stimulated NK activity and augmentation was particularly evident in the Mls-disparate combinations. Thus, the same alloantigens which efficiently activate T cells also activate NK cells.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D001854:Bone Marrow Cells; D003602:Cytotoxicity, Immunologic; D004306:Dose-Response Relationship, Immunologic; D006183:H-2 Antigens / Q000276:immunology*; D007519:Isoantigens; D007694:Killer Cells, Natural / Q000276:immunology*; D007700:Kinetics; D008198:Lymph Nodes / Q000166:cytology; D051379:Mice; D008805:Mice, Inbred A / Q000276:immunology; D008807:Mice, Inbred BALB C / Q000276:immunology; D008809:Mice, Inbred C3H / Q000276:immunology; D008810:Mice, Inbred C57BL / Q000276:immunology; D008808:Mice, Inbred CBA / Q000276:immunology; D013154:Spleen / Q000166:cytology; D013950:Thymus Gland / Q000166:cytology
D006183:H-2 Antigens; D007519:Isoantigens