Analgesic properties of the GABA-mimetic THIP.
The analgesic properties of the muscimol analogue THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) in laboratory animals were compared with those of baclofen, morphine and muscimol. THIP was active orally and parenterally and resembled muscimol qualitatively in its actions. Quantitatively, THIP and baclofen were 2--3 times less potent than morphine and 5--15 times less potent than muscimol. The analgesic effects of THIP, baclofen and muscimol were not reversed by naloxone or bicuculline.
D000700:Analgesics; D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy; D001418:Baclofen / Q000494:pharmacology; D004558:Electric Stimulation; D007555:Isoxazoles / Q000494:pharmacology*; D008253:Macaca mulatta; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009118:Muscimol / Q000494:pharmacology; D010080:Oxazoles / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects
D000700:Analgesics; D007555:Isoxazoles; D010080:Oxazoles; D009118:Muscimol; D009020:Morphine; D001418:Baclofen; C015542:gaboxadol