[Studies on the total synthesis of cholecystokinin-pancreozymin. Synthesis of the suitably protected fragment corresponding to the sequence 24--33 (author's transl)].
The synthesis is described of a suitably protected decapeptide derivative corresponding to the C-terminal tyrosin-O-sulfate-containing sequence 24--33 of cholecystokinin-pancreozymin as key fragment for the total synthesis of this gastrointestinal hormone or its 39-variant. This peptide derivative has been prepared according to our newly developed procedure based on the direct use of N-acyltyrosine-O-sulfate barium salt. Additionally, removal of the protecting groups followed by purification via chromatographic methods produced the decapeptide amide in good yields and with a high degree of purity as a fully active cholecystokinin-pancreozymin related peptide.
D002766:Cholecystokinin / Q000138:chemical synthesis*; D008722:Methods; D010446:Peptide Fragments / Q000138:chemical synthesis; D014443:Tyrosine / Q000031:analogs & derivatives
D010446:Peptide Fragments; C005662:tyrosine O-sulfate; D014443:Tyrosine; D002766:Cholecystokinin
Zur Totalsynthese von Cholecystokinin-Pankreozymin. Darstellung des verknüpfungsfhigen "Schläusselfragments" der Sequenz 24--33.