Induction of DNA repair by some selenium compounds.
Selenium compounds were found to induce DNA repair synthesis as a measure of DNA damage in both the isolated rat liver cell system and by Ames' Salmonella assay. In liver cells, DNA repair measured by uptake of [3H]thymidine was found to be greater with sodium selenite and selenate than with selenomethionine. In the bacterial culture system, selenomethionine inhibited the repair-deficient variant more than the selenite and selenate. These in vitro test systems have been used to indicate that selenium has a DNA-damaging potential.
D000818:Animals; D004260:DNA Repair / Q000187:drug effects*; D005260:Female; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D051381:Rats; D012475:Salmonella / Q000378:metabolism; D012643:Selenium / Q000494:pharmacology*
D012643:Selenium