title: The evolution of the radiologic lead line.
abstract: Serial radiographs of lead-poisoned children showed separation of lead lines from the zone of provisional calcification within four weeks at sites of rapid growth. Lead lines do not appear until blood lead attains a concentration of 70 to 80 micrograms/dl. They are not affected by treatment, but disappear spontaneously within four years. While they remain in the diaphysis, they provide a marker for the time of onset of lead toxicity and the subsequent rate of bone growth.
mesh_terms: D001846:Bone Development; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007854:Lead / Q000097:blood; D007855:Lead Poisoning / Q000000981:diagnostic imaging*; D008297:Male; D011859:Radiography; D013997:Time Factors
chemical_list: D007854:Lead