Acute sino-aortic denervation in rats produces a selective increase of adrenaline turnover in the dorsal midline area of the caudal medulla oblongata and a reduction of adrenaline levels in the anterior and posterior hypothalamus.
Acute sino-aortic denervation produces an acute reduction of adrenaline stores in the anterior and posterior hypothalamus and a reduction of noradrenaline stores in the dorsal midline area of the caudal medulla oblongata. Furthermore, removal of baroreflex afferents results in an increase of adrenaline turnover in the DCMO but not in the hypothalamus. The present findings give evidence for participation of adrenergic mechanisms in central baroreflex regulation. The findings can be interpreted according to the adrenaline vasodepressor hypothesis of hypertension.
D000818:Animals; D001011:Aorta / Q000294:innervation; D002346:Carotid Sinus / Q000294:innervation; D003714:Denervation; D004298:Dopamine / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D007032:Hypothalamus, Anterior / Q000378:metabolism; D007034:Hypothalamus, Posterior / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D011311:Pressoreceptors / Q000502:physiology*; D051381:Rats
D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine