[Evaluation of certain local immunity factors in patients with infectious-allergic bronchial asthma and therapy with immunostimulators].
Among the patients with the allergic infectious bronchial asthma accompanied by the chronic recurring infection of the respiratory organs a decrease in the immunoglobulin level of bronchial secretion, as compared with the normal level, was revealed in 72.1%, and the absence of IgA or SIgA in 23%. The immunofluorescent study of the biopsy specimen of the bronchial mucous membrane confirmed the suppression of local immunity accompanied by the decreased number of immunoglobulin-producing cells in the epithelium and the subjacent connective tissue, by changes in the basal membrane and by the sclerosis of the mucous membrane. Immunostimulating therapy with levamisol yielded good results, especially in patients with decreased local immunity, including patients receiving glucocorticosteroids. The complete absence of immunoglobulin-producing cells in the bronchial mucous membrane is prognostically infavorable: this condition may be the cause of immunotherapy having a weak effect, even to the point of being ineffective.
D001249:Asthma / Q000097:blood / Q000150:complications / Q000276:immunology* / Q000628:therapy; D001980:Bronchi / Q000276:immunology*; D001991:Bronchitis / Q000150:complications; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000378:metabolism*; D007978:Levamisole / Q000627:therapeutic use*; D011014:Pneumonia / Q000150:complications
D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D007978:Levamisole
Otsenka nekotorykh faktorov mestnogo immuniteta u bol'nykh infektsionno-allergicheskoĭ bronkhial'noĭ astmoĭ i terapiia immunostimuliatorami.