[Experimental and clinical studies concerning the influence of natural substances on the crystallization of calcium oxalate (author's transl)].
Krapp-Hydroxyanthrachinone given orally will, in a dosage of 150-200 mg, inhibit the intra-renal crystallization of calcium oxalate in the rabbit kidney following Glyoxalate intoxication. This inhibition is increased considerably by Na-Cu-Chlorophylline. The mechanism of action of the inhibitor substances is a specific surface adsorption prohibiting formation of microliths. This can also be shown in precipitation experiments in vitro. The authors suggest a certain clinical use of a combination of the tested dye with vitamin B6, citrate and magnesium preparations.
D000818:Animals; D002129:Calcium Oxalate / Q000378:metabolism* / Q000652:urine; D002735:Chlorophyllides / Q000378:metabolism; D003460:Crystallization; D004347:Drug Interactions; D006038:Glyoxylates / Q000378:metabolism; D006801:Humans; D007669:Kidney Calculi / Q000209:etiology / Q000517:prevention & control; D011817:Rabbits
D002735:Chlorophyllides; D006038:Glyoxylates; D002129:Calcium Oxalate; C007020:chlorophyllin; C031150:glyoxylic acid
Tierexperimentelle und klinische Studien zum Einfluss von Naturstoffen auf die Kristallisation von Kalziumoxalat.