[Features of hematopoiesis in mice protected from the lethal effect of cytosar by deoxycytidine].
Simultaneous administration to B6 female mice of deoxycytidine in doses exceeding 2--3-fold those of cytosar (20 mg/kg three times a day for 4 days) prevents lethal toxicity induced by cytosar, protects the bone marrow and spleen, hemopoietic stem cells, myeloid and erythroid cells of the bone marrow, spleen and blood. It also protects spleen and blood lymphocytes from cytosar toxic effect by does not protect thymus or bone marrow lymphocytes.
D000818:Animals; D001855:Bone Marrow Diseases / Q000139:chemically induced; D003114:Colony-Forming Units Assay; D003561:Cytarabine / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006402:Hematologic Diseases / Q000139:chemically induced / Q000517:prevention & control; D006413:Hematopoietic System; D051379:Mice; D008810:Mice, Inbred C57BL; D013158:Splenic Diseases / Q000139:chemically induced; D013950:Thymus Gland
D003561:Cytarabine; D003841:Deoxycytidine
Osobennosti krovetvoreniia mysheĭ, zashchishchennykh dezoksitsitidinom ot letal'nogo éffekta tsitozara.