title: Effect of glucagon on arrhythmias induced by coronary artery occlusion and ouabain in dogs.
abstract: The effect of glucagon in arrhythmias induced by coronary artery occlusion and ouabain was studied in dogs. Intravenous administration of glucagon (50 microgram/kg) to 6 dogs with more than 70% ectopic activity after coronary artery occlusion, resulted in significant (P less than 0.01) decrease in ectopics and increase in heart rate. Infusion of glucagon (2.5 microgram/kg/min) for 30 min caused complete elimination of ectopic activity during infusion period. In another series of 7 experiments, glucagon failed to abolish the ouabain-induced ectopic beats. In fact the hormone itself caused a significant (P less tha 0.01) increase in ectopic activity and heart rate. However, in 7 dogs with complete heart block produced after ouabain conversion to normal sinus rhythm was observed after glucagon.
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology; D003331:Coronary Vessels / Q000502:physiology; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D005934:Glucagon / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D010042:Ouabain / Q000494:pharmacology
chemical_list: D000889:Anti-Arrhythmia Agents; D010042:Ouabain; D005934:Glucagon