Effects of repeated administrations of dihydroergotoxine (Redergine) on the sleep-wakefulness cycle in the cat.
Investigations with dihydroergotoxine methane sulfonate (DHET, the active substance of Redergine) indicate that DHET acts on the sleep-wakefulness cycle of the cat by increasing wakefulness and slow-wave sleep and decreasing rapid eye movement sleep. DHET was administered intraperitoneally at a dose of 1.0 mg/kg for 5 successive days. The effects were fairly stable, although with a tendency to diminish with time. Such alterations in the sleep-wakefulness cycle are discussed as possible indices of the beneficial effects seen in elderly patients treated with DHET.
D000818:Animals; D002415:Cats; D002940:Circadian Rhythm / Q000187:drug effects*; D004088:Dihydroergotoxine / Q000494:pharmacology*; D008297:Male; D012894:Sleep Stages / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects; D014851:Wakefulness / Q000187:drug effects*
D004088:Dihydroergotoxine