Hepatic involvement in systemic lupus erythematosus. A case report.
The existence of hepatic involvement in systemic lupus erythematosus (SLE) is still contested in the literature. We report a patient with SLE and deranged liver function tests, especially marked elevation of alkaline phosphatase levels, an association not hitherto described. These changes have persisted for 3 1/2 years with no evidence of chronic active hepatitis (CAH) on liver biopsy or biliary obstruction. Current concepts of liver involvement in SLE, 'lupoid' hepatitis and aspirin hepatotoxicity are reviewed.
D000328:Adult; D000469:Alkaline Phosphatase / Q000032:analysis; D001241:Aspirin / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008107:Liver Diseases / Q000209:etiology*; D008111:Liver Function Tests; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000378:metabolism
D000469:Alkaline Phosphatase; D001241:Aspirin