Immunotherapy of experimental cancer with a mixture of synthetic muramyl dipeptide and trehalose dimycolate.
The antitumor activity of a mixture of synthetic N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) and trehalose-6,6'-dimycolate (TDM) (MDP+TDM) in emulsified form was studied in guinea pigs, each with a syngeneic dermal tumor and microscopically detectable metastases in regional lymph nodes. A single intralesional administration of an ultrasonically prepared emulsion containing MDP+TDM in squalane or in mineral oil caused tumor regression and elimination of lymph node metastases. Similar emulsions of MDP+TDM made with squalene or hexadecane were immunotherapeutically inactive.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000627:therapeutic use*; D000473:Alkanes / Q000627:therapeutic use; D000818:Animals; D002473:Cell Wall / Q000276:immunology; D004187:Disaccharides / Q000627:therapeutic use*; D005260:Female; D005615:Freezing; D006020:Glycopeptides / Q000627:therapeutic use*; D006168:Guinea Pigs; D008297:Male; D008899:Mineral Oil / Q000627:therapeutic use; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*; D013185:Squalene / Q000031:analogs & derivatives / Q000627:therapeutic use; D014199:Trehalose / Q000627:therapeutic use*
D000473:Alkanes; D004187:Disaccharides; D006020:Glycopeptides; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D013185:Squalene; D008899:Mineral Oil; D014199:Trehalose; C007932:n-hexadecane; C019556:squalane