[The effects of cytostatic agents - methotrexate, actinomycin-D and cyclophosphamide - on in vitro metabolism of human placenta from early pregnancy (author's transl)].
The effects of methotrexate, actinomycin-D and cyclophosphamid on oxygen consumption, aerobic CO2-production and anaerobic glycolysis of human placentas from early pregnancy were studied on Warburg apparatus. All the mentioned cytostatic agents inhibited oxygen consumption. Aerobic CO2-production was increased  by methotrexate and inhibited by actinomycin-D and cyclophosphamide, but blocking effect of the latter was only transitional. Anaerobic glycolysis was decreased continuously by actinomycin-D and cyclophosphamide, but methotrexate had decreasing effect only for a short time.
D003520:Cyclophosphamide / Q000494:pharmacology*; D003609:Dactinomycin / Q000494:pharmacology*; D005260:Female; D006019:Glycolysis / Q000187:drug effects; D006801:Humans; D008727:Methotrexate / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D010920:Placenta / Q000187:drug effects* / Q000378:metabolism; D011247:Pregnancy
D003609:Dactinomycin; D003520:Cyclophosphamide; D008727:Methotrexate
Uber die Wirkung von Zytostatika: Methotrexat, Actinomycin-D und Cyclophosphamide auf den in vitro Stoffwechsel der humanen Frühplazenta.