Urothelial susceptibility to tumor cell implantation: influence of cauterization.
In an effort to determine whether transitional tumor cells will preferentially implant on the cauterized urothelial surface, a reproducible technique for cauterization of a portion of the murine bladder was established. This technique simulated a transurethral fulguration of a bladder tumor in humans. Transplantable tumor cells (1 X 10(6)) were placed transurethrally into the bladder of 50 mice. Twenty-five of these mice each had a portion of their bladder cauterized prior to insertion of tumor cells. Implantation with subsequent tumors occurred in 54% of mice with cauterization, in contrast to 12% of mice with an intact urothelial surface (P less than 0.005). Intravesical thio-tepa, mitomycin C, and cis-platinum were capable of significantly reducing the incidence of implantation. These results suggest that seeding may be a contributing factor to the high recurrence rate following endoscopic resection or fulguration of bladder tumors and that intravesical chemotherapy initiated shortly after surgery may reduce the incidence of implantation.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D003558:Cystoscopy / Q000009:adverse effects; D004564:Electrocoagulation; D004848:Epithelium / Q000601:surgery; D005260:Female; D051379:Mice; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D009366:Neoplasm Seeding; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000209:etiology / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000209:etiology / Q000601:surgery*
D000970:Antineoplastic Agents