An investigation of the antitumor activity of Sesbania drummondii.
Extracts of Sesbania drummondii (Rydb.) Cory seed are active in vivo in the P-388 lymphocytic leukemia system and cytotoxic in the KB assay. Systematic fractionation of S. drummondii has yielded sesbanine (1), a novel spirocyclic alkaloid based on the 2,7-naphthyridine nucleus, and drummondol (2), a new abscisic acid (5) metabolite. Sesbanine and drummondol are present in highly cytotoxic fractions; however, these purified compounds are essentially devoid of antitumor activity
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D001643:Bridged Bicyclo Compounds / Q000302:isolation & purification / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002294:Carcinoma, Squamous Cell; D002478:Cells, Cultured; D006801:Humans; D009287:Naphthyridines / Q000302:isolation & purification / Q000494:pharmacology; D010947:Plants, Toxic / Q000032:analysis*; D013141:Spiro Compounds
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D009287:Naphthyridines; D013141:Spiro Compounds; C029813:sesbanine; C029812:drummondol