title: Combined inhibition of vaccinia virus multiplication by inhibitors of DNA synthesis.
abstract: Nine purine or pyrimidine analogues or other inhibitors of DNA synthesis were studied for their inhibition of vaccinia virus multiplication by a plaque inhibition test with a fluid overlay in Vero cell cultures, either as single substances or in combination. Experiments on combined inhibition were made with substance concentrations leading to 80-90% plaque inhibition; indifference, additive, or synergistic interaction were evaluated from normalized plaque counts. 12 substance pairs acted in a synergistic manner and 22 showed indifference. A comparison was made with the results of other DNA viruses (adenovirus, herpes simplex virus).
mesh_terms: D004247:DNA / Q000096:biosynthesis*; D004357:Drug Synergism; D014616:Vaccinia virus / Q000187:drug effects*; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D004247:DNA