[Human sex skin fibroblast cultures : a useful tool for diagnosis of male pseudohermaphroditism due to target organ unresponsiveness to androgens (author's transl)].
Sex skin fibroblast cultures were reported to constitute a fair model for studying male pseudohermaphroditism (MPH) due to target organ unresponsiveness to androgens. Using this technique, we made the diagnosis of MPH due to steroid 5 alpha-reductase deficiency, complete or partial androgen insensitivity. This technique gave the opportunity to describe an unstable form of 5 alpha-reductase and a thermolability of androgen receptors responsible for MPH. This method permitted a better understanding of disorders of male sex differentiation.
D000728:Androgens / Q000502:physiology*; D002478:Cells, Cultured; D012734:Disorders of Sex Development / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology*; D005347:Fibroblasts / Q000473:pathology; D005837:Genitalia, Male / Q000166:cytology*; D006801:Humans; D008297:Male
D000728:Androgens
La culture de fibroblastes : moyen d'étude des anomalies de l'action cellulaire des androgènes au cours du pseudo-hermaphrodisme mäle.