Mechanisms of neurotoxicity as studied in tissue culture systems.
This presentation focused on describing the unique aspects of nervous tissue which make it susceptible to toxicological insult. It reviewed the published literature of compounds that have been studied in tissue culture of nerve tissue and compared the data in vivo toxicity studies with that obtained from the tissue culture system. Further, neuronal activity as a determinant of neurotoxicity was discussed as a basic mechanism to understand toxicological outcomes.
D000535:Aluminum / Q000633:toxicity; D000818:Animals; D002460:Cell Line; D046508:Culture Techniques; D004353:Drug Evaluation, Preclinical; D007608:Kainic Acid / Q000633:toxicity; D008628:Mercury / Q000633:toxicity; D008742:Methyl n-Butyl Ketone / Q000633:toxicity; D051379:Mice; D009420:Nervous System / Q000187:drug effects*; D009447:Neuroblastoma / Q000473:pathology; D010261:Paraoxon / Q000633:toxicity; D013116:Spinal Cord / Q000187:drug effects
D008742:Methyl n-Butyl Ketone; D000535:Aluminum; D008628:Mercury; D010261:Paraoxon; D007608:Kainic Acid