title: Electron microscopic demonstration of adenylate cyclase activity in rat cortical synaptosomes.
abstract: The electron cytochemical demonstration of adenylate cyclase activity was carried out in rat cortical synaptosomes. Reaction product was found in 60-70% of the synaptosomes in three predominant localization: (i) on the postsynaptic density; (ii) on the outer aspect of the synaptosomal membrane; (iii) inside the synaptosome. Results suggest that in addition to postsynaptic localization adenylate cyclase activity is cytochemically demonstrable also at presynaptic sites.
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000201:enzymology*; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D013574:Synaptosomes / Q000201:enzymology*
chemical_list: D000262:Adenylyl Cyclases