Adrenal scintigraphy in primary aldosteronism caused by an aldosterone producing adenoma.
Adrenal scintigraphy with 131I-19-iodo-cholesterol was performed in 13 hypertensive patients with biochemical disturbances suggesting an aldosterone-producing adenoma. The actual presence of an adenoma was subsequently confirmed in all cases. An asymmetrical tracer uptake (lateralization) was seen in 7 patients and in 6 of these the adenoma was located in the adrenal with the higher uptake. In one patient a large necrotic tumour was not visualized and a faint contralateral accumulation was wrongly taken to represent a tumour. In 6 patients the scintigram was non-lateralizing. In these highly selected patients a lateralizing scintigram had a high diagnostic specificity and at present adrenal scintigraphy should be the method of first choice in the preoperative side prediction. However, the sensitivity is low: a non-lateralizing scintigram does not exclude the presence of an aldosterone-producing adenoma.
D000236:Adenoma / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism; D000328:Adult; D000450:Aldosterone / Q000096:biosynthesis; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging
D000450:Aldosterone