Effects of extracts of denervated muscles on the morphology of cultured muscle cells.
Previously, trophic effects of extracts from whole chick embryos and from innervated muscles on cultured muscle cells were described. The present study demonstrated similar effects of extracts from 10-days denervated chick muscles. Extracts from innervated as well as from denervated muscles exsanguinated in vivo with saline prior to dissection showed only marginal trophic activity, suggesting a major contribution of serum components to the trophic effects of tissue extracts. Indeed, serum of adult chicks appeared to have a trophic action similar to that of chick embryo extract.
D000818:Animals; D001769:Blood; D002478:Cells, Cultured; D002642:Chick Embryo; D002645:Chickens; D009121:Muscle Denervation; D009132:Muscles / Q000166:cytology*