[Spontaneous cell-mediated cytotoxicity of blood granulocytes and monocytes in vitro].
The in vitro studied bovine blood leucocytes display a spontaneous cell-mediated cytotoxicity (SCT) against 3H-thymidine labeled xenogeneic target cells L, estimated by the residual radioactivity. Using the effector-target cellular complex assay, it was found that cells of the heterogenous blood leucocyte population had different spontaneous target-binding activities. Granulocytes--eosinophils and neutrophils--were the most active effectors in the formation of effector-target cellular complexes during blood leucocyte SCT. The mononuclear SCT was represented by monocytes, while the spontaneous lymphocyte target-binding activity was very low. No basophil association with targets was detected.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D002417:Cattle; D006098:Granulocytes / Q000276:immunology*; D007111:Immunity, Cellular; D007694:Killer Cells, Natural / Q000276:immunology; D007739:L Cells / Q000276:immunology; D009000:Monocytes / Q000276:immunology*; D013997:Time Factors
Spontannaia kletochno oposredovannaia tsitotoksichnost' granulotsitov i mononuklearov krovi in vitro.