title: Castor bean allergens: evidence for distinct heat-labile and stable entities.
abstract: Castor beans contain one of the most potent allergens known to man. Previous studies suggested that these allergens are heat-stable; but our current data suggest that both heat-stable and labile allergens are present in castor bean extracts. The heat-labile allergen is of large molecular weight and is immunochemically distinct from the smaller molecular weight heat-stable allergen. Both allergens have different isoelectric points. These antigens may be clinically relevant since coffee workers sensitized to castor have IgE antibodies to both allergens.
mesh_terms: D000485:Allergens / Q000302:isolation & purification*; D002367:Ricinus communis / Q000276:immunology*; D003069:Coffee; D003429:Cross Reactions; D006358:Hot Temperature; D006801:Humans; D007525:Isoelectric Focusing; D008970:Molecular Weight; D010936:Plant Extracts / Q000276:immunology; D010947:Plants, Toxic; D012278:Ricinus / Q000276:immunology*; D012882:Skin Tests
chemical_list: D000485:Allergens; D003069:Coffee; D010936:Plant Extracts