Murine spermatogonial regeneration after exposure to either X-rays or 15 MeV neutrons.
The long-term regeneration of the seminiferous epithelium after irradiation with 15 MeV neutrons was studied in the mouse on a comparative basis; 150 kV X-rays were used as reference-radiation. The mice received total-body exposures at matched doses. The spermatogonial Regeneration Index (RI) was scored from stained paraffin-sections of testes which were obtained after periodic sacrifice. A biphasic pattern of regeneration was recorded. Dose-independent and dose-dependent effects have been indicated. The radiobiological implications are discussed on a cellular basis.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005214:Fast Neutrons; D008297:Male; D051379:Mice; D012038:Regeneration / Q000528:radiation effects*; D013093:Spermatogonia / Q000502:physiology / Q000528:radiation effects*; D013094:Spermatozoa / Q000528:radiation effects*; D013997:Time Factors