Effects of temperature on sister chromatid exchanges.
The influence of temperature on sister chromatid exchanges was investigated, and the results are discussed in connection with factors possible involved in temperature-induced SCE-formation. Whereas the SCE frequency increased with increasing growth temperature in a cell line of Xenopus laevis (EAX), which permits the examination of great temperature differences, a Chinese hamster cell line (V-79) revealed a U-shaped temperature-response curve. In addition, it was found that cold treatment at 4 degrees C caused an induction of SCEs in the V-79 cell line. Different BrdU concentrations had no effect on the temperature-induced SCE frequencies and mitomycin C led to an induction of SCEs parallel to the base-line values at different temperatures.
D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D003434:Crossing Over, Genetic / Q000187:drug effects; D005347:Fibroblasts; D008937:Mitomycins / Q000494:pharmacology; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013696:Temperature; D014981:Xenopus
D008937:Mitomycins; D001973:Bromodeoxyuridine