Lack of effect of pancreatic polypeptide in the rate of gastric emptying and gut hormone release during breakfast.
Bovine pancreatic polypeptide (PP) was infused intravenously in 5 healthy subjects on two separate occasions with mean doses of 1 and 2 pmol kg-1 min-1, respectively, which achieved plasma levels equal to and twice those observed after a normal mixed breakfast. The gastric emptying rate of a carbohydrate-rich breakfast 20 min after the start of each PP infusion was not significantly different from a control infusion of 0.15 M saline. PP is unlikely to be an important physiological modulator of gastric emptying rate in man.
D000328:Adult; D005215:Fasting; D005746:Gastric Emptying / Q000187:drug effects*; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D006801:Humans; D007263:Infusions, Parenteral; D008875:Middle Aged; D010187:Pancreatic Hormones / Q000378:metabolism*; D010191:Pancreatic Polypeptide / Q000494:pharmacology*
D005768:Gastrointestinal Hormones; D010187:Pancreatic Hormones; D010191:Pancreatic Polypeptide