The cardiovascular stress of photochemotherapy (PUVA).
The recently devised therapy for psoriasis and related skin diseases, consisting of long-wave ultraviolet light and oral 8-methoxypsoralen (PUVA), was investigated for its cardiovascular effects. In seventeen patients, long-wave ultraviolet light therapy in a treatment enclosure (mean duration, 19.3 minutes) resulted in ambient temperatures of 39.2 degrees C +/- 2.1 degrees C (SD) and skin temperatures of 38.2 degrees C +/- 1.4 degrees C. In upright subjects, heart rate rose 30.8% to 114.4 +/- 25.2 beats per minute (bpm). Intensive room air conditioning, outside of the treatment enclosure, although significantly lowering skin and ambient temperatures, did not affect the heart rates significantly. PUVA therapy is associated with a definite cardiovascular stress when the box type of therapeutic unit is used. Possible modifications are discussed.
D000328:Adult; D000389:Air Conditioning; D001794:Blood Pressure / Q000528:radiation effects; D001831:Body Temperature / Q000528:radiation effects; D002319:Cardiovascular System / Q000187:drug effects / Q000528:radiation effects*; D005260:Female; D006339:Heart Rate / Q000528:radiation effects; D006801:Humans; D008297:Male; D008730:Methoxsalen / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged; D010778:Photochemotherapy / Q000009:adverse effects*; D011565:Psoriasis / Q000628:therapy*; D014467:Ultraviolet Therapy
D008730:Methoxsalen