[Hypobaric hypoxia effects on a conditioned avoidance response and on ADP, AMP dopamine and noradrenaline cerebral levels in rats treated or not with naftidrofuryl (author's transl)].
Hypobaric hypoxia (300 mm Hg = 7180 m) was performed during 30 min. for a day during five consecutive days in rats treated or not with naftidrofuryl (15 mg/kg- i.p. daily). A conditioned avoidance response studied on five days shows a reduction of the performances in control rats but not ir treated ones. AMP and ADP cerebral levels were unchanged in the two groups. Hypoxia induced in control rats a reduction of the catecholamine cerebral levels which was not observed in treated rats. In conclusion the protection afforded by naftidrofuryl seems to be due mainly to a reduction of the catecholamine utilization during hypoxia.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000818:Animals; D001274:Atmospheric Pressure; D001362:Avoidance Learning / Q000502:physiology*; D001923:Brain Chemistry / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism; D005260:Female; D005663:Furans / Q000494:pharmacology*; D000860:Hypoxia / Q000523:psychology*; D009257:Nafronyl / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats
D005663:Furans; D000249:Adenosine Monophosphate; D009257:Nafronyl; D000244:Adenosine Diphosphate; D004298:Dopamine; D009638:Norepinephrine
Effets de l'hypoxie hypobare sur le conditionnement et les taux cérébraux d'ADP, d'AMP, de dopamine et de noradrenaline chez le rat traité ou non par le naftidrofuryl.