The effect of levamisole in experimental murine amyloidosis.
In casein-induced murine amyloidosis various lines of investigation have implicated immunodeficiency as playing a role in amyloid formation. In this study, the immunopotentiating agent levamisole failed to prevent amyloidogenesis or to accelerate resolution of preformed amyloid deposits in the mouse model. The serum precursor of amyloid, serum amyloid protein A (SAA), was increased by levamisole in both normal and amyloidotic mice.
D000042:Absorption; D000682:Amyloid / Q000096:biosynthesis; D000686:Amyloidosis / Q000139:chemically induced / Q000378:metabolism*; D000818:Animals; D002364:Caseins; D005260:Female; D007978:Levamisole / Q000494:pharmacology*; D051379:Mice; D000685:Serum Amyloid A Protein / Q000096:biosynthesis
D000682:Amyloid; D002364:Caseins; D000685:Serum Amyloid A Protein; D007978:Levamisole