title: Free fatty acid composition of human and rat peripheral nerve.
abstract: The free fatty acid (FFA) composition of peripheral nerve resembles that of erythrocytes but the composition of both is different from that of brain and other tissues. Approximately 75% of FFAs of nerve and erythrocytes are saturated and less than 5% are polyunsaturated whereas in brain and other tissues, 30-45% of FFAs are saturated and 25-50% are polyunsaturated. Approximately 10-15% of the total FFA of nerve have very long chain lengths [C24, C26, C28, and C30]. The presence of these very long-chain FFAs in endoneurium cannot be accounted for by the retention of erythrocytes or by lipid degradation. During Wallerian degeneration a significant increase of 18:1, associated with a decrease of saturated FFAs, was found in rat sciatic endoneurium, but normal values were approached when fiber regeneration was well under way. The FFA composition with chain length greater than or equal to C26 were not, however, significantly altered with degeneration or repair of nerves. The metabolic significance of this striking difference between nerve and brain FFA composition is unknown but may reflect different functional properties.
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D004912:Erythrocytes / Q000032:analysis; D005230:Fatty Acids, Nonesterified / Q000032:analysis* / Q000097:blood; D006801:Humans; D066298:In Vitro Techniques; D010525:Peripheral Nerves / Q000032:analysis*; D010743:Phospholipids / Q000032:analysis; D051381:Rats; D013107:Sphingolipids / Q000032:analysis; D014855:Wallerian Degeneration
chemical_list: D005230:Fatty Acids, Nonesterified; D010743:Phospholipids; D013107:Sphingolipids