[Double blind study of the influence of aristolochic acid on granulocyte phagocytic activity].
In two double blind studies, separated by a time interval, the influence on phagocytic activity of peripheral granulocytes was investigated by aid of 3H-labelled staphylococci following administration of therapeutic doses of aristolochic acid, a nitrophenanthrene carboxylic acid derivative, to 12 healthy test subjects. Both double blind studies showed that aristolochic acid in a dosage of 0.9 mg/d produced a definite increase in phagocytic activity in healthy test persons after the third day of treatment; this increase reached a maximum within a 10-day treatment period between the seventh and tenth days; following discontinuation of treatment normal values were recorded again within a week. Other laboratory parameters investigated were not influenced.
D000328:Adult; D034341:Aristolochic Acids; D001770:Blood Bactericidal Activity / Q000187:drug effects; D004311:Double-Blind Method; D006098:Granulocytes / Q000187:drug effects*; D006801:Humans; D008297:Male; D010587:Phagocytosis / Q000187:drug effects*; D010616:Phenanthrenes / Q000494:pharmacology*; D013997:Time Factors
D034341:Aristolochic Acids; D010616:Phenanthrenes; C000228:aristolochic acid I
Doppelblindstudie zur Beeinflussung der Phagozytosefähigkeit von Granulozyten durch Aristolochiasäure.