The migration of Strongyloides papillosus in rabbits following infection by the oral and subcutaneous routes.
For the first 66 hours after the subcutaneous injection of rabbits with the infective larvae of Strongyloides papillosus, larvae spread gradually from the injection site to other parts of the body musculature. Their number and distribution suggests that they do so by the direct penetration of the tissues as the majority remain close to the site of injection. By 90 hours, however, the appearance of larvae in the lungs, trachea and oesophagus suggests that migration is taking place within the circulation. Although some 90% of the total worms recovered were already established in the intestine by 8 days post-infection, significant numbers of larvae continued to be present in the muscles at 14 and 21 days. Even by 35 days the muscles of 1 of 2 rabbits still contained 43 larvae. This prolonged presence of Strongyloides papillosus in the muscle of rabbits uniformly at the early fourth stage may be analogous to the arrested development of other nematodes. While there is evidence to suggest that immunity is a major factor in the aetiology of arrested development in Strongyloides ransomi, it is an unimportant factor in the case of Strongyloides papillosus in rabbits.
D000818:Animals; D007114:Immunization; D007422:Intestines / Q000469:parasitology; D009068:Movement; D009132:Muscles / Q000469:parasitology; D011817:Rabbits; D012137:Respiratory System / Q000469:parasitology; D013321:Strongyloides / Q000276:immunology / Q000502:physiology*; D013322:Strongyloidiasis / Q000469:parasitology*; D013773:Tetramisole / Q000494:pharmacology; D013997:Time Factors
D013773:Tetramisole