Creatine kinase MB isoenzyme in dermatomyositis: a noncardiac source.
Three patients with polymyositis had elevated serum levels of creatine kinase MB isoenzyme. The presence of this isoenzyme is used extensively to diagnose myocardial infarction, but the isoenzyme is also found in sera of patients with primary muscular and neuromuscular disorders. We studied cardiac function in two of our patients with electrocardiograms, technetium stannous pyrophosphate scanning, and technetium 99m-labeled erythrocyte gated blood pool imaging and in the third patient by postmortem examination. There was no evidence of myocardial involvement to account for the high serum levels of isoenzyme. Creatine kinase MB in the sera of patients with polymyositis does not necessarily indicate myocardial necrosis.
D000328:Adult; D003402:Creatine Kinase / Q000097:blood*; D003882:Dermatomyositis / Q000000981:diagnostic imaging / Q000201:enzymology* / Q000473:pathology; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008875:Middle Aged; D009132:Muscles / Q000201:enzymology / Q000473:pathology; D009203:Myocardial Infarction / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology / Q000473:pathology; D013902:Radiography, Thoracic; D011877:Radionuclide Imaging; D013667:Technetium; D016698:Technetium Tc 99m Pyrophosphate; D014003:Tin Polyphosphates
D007527:Isoenzymes; D014003:Tin Polyphosphates; C017742:technetium Tc 99m stannous pyrophosphate; D016698:Technetium Tc 99m Pyrophosphate; D013667:Technetium; D003402:Creatine Kinase