In vitro transformation of hamster embryo cells by 3-(N-salicyloyl)amino-1,2,4-triazole.
The in vitro carcinogenic activities of 3-(N-salicyloyl)amino-1,2,4-triazole (SAT) and its two components, 3-amino-1,2,4-triazole and phenyl salicylate were examined in a transformation assay with cryopreserved hamster embryo cells. SAT induced morphological transformation at certain doses between 10 microgram/ml and 100 microgram/ml in each of 5 repeated experiments, but gave a negative result in the Salmonella mutation assay. 3-Amino-1,2,4-triazole also induced transformation in 3 repeated experiments. Phenyl salicylate did not induce transformation at any of the doses tested in 3 consecutive experiments.
D000640:Amitrole / Q000031:analogs & derivatives / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D006224:Cricetinae; D004622:Embryo, Mammalian; D009153:Mutagens; D012459:Salicylates / Q000633:toxicity; D014230:Triazoles / Q000633:toxicity*
D002273:Carcinogens; D009153:Mutagens; D012459:Salicylates; D014230:Triazoles; C026041:phenyl salicylate; C029566:3-(N-salicyloyl)amino-1,2,4-triazole; D000640:Amitrole