title: Activity of non-specific esterases in the marrow-cells of rats after the injection of mercury and lead.
abstract: The studies were carried out with Wistar female rats at the age of about two months, each weighting 150 g, treated with HgCl2 and Pb(CH3COO)2. The animals were injected intramuscularly with applied preparations of both compounds in a dose of 0,2 mg of unalloyed metal per 100 g of a body weight per day, during 6 days. The activity of the enzyme was studied in the marrow-cells of rats from the control series as well as from both experimental series. The activity of non-specific esterases decreased in the majority types of the marrow-cells after the application of mercury. On the other hand, the application of lead caused an increase of the activity of esterases in almost all cells together with lymphocytes.
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors; D004950:Esterases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000201:enzymology*; D007273:Injections, Intramuscular; D007854:Lead / Q000008:administration & dosage; D008533:Megakaryocytes / Q000201:enzymology*; D008628:Mercury / Q000008:administration & dosage; D051381:Rats
chemical_list: D004791:Enzyme Inhibitors; D007854:Lead; D004950:Esterases; D008628:Mercury