title: Regulation of cellulase synthesis in Acetivibrio cellulolyticus.
abstract: A mesophilic anaerobe, Acetivibrio cellulolyticus, isolated from a cellulose-enrichment culture, degraded cellulose by the secretion of cellulolytic enzymes into the culture medium. Both exo- and endoglucanase activities were detected and shown to be regulated by induction and catabolite repression. Endoglucanase synthesis was induced by cellulose, cellobiose and salicin. Synthesis induced during growth on cellobiose was inhibited, although not completely repressed by glucose. Exoglucanase activity was enhanced when cells were grown on insoluble or soluble poly beta-glucoside polymers. Activity was progressively inhibited by supplementing microcrystalline substrates with increasing amounts of cellobiose.
mesh_terms: D000693:Anaerobiosis; D001419:Bacteria / Q000201:enzymology*; D002475:Cellobiose / Q000494:pharmacology; D002480:Cellulase / Q000096:biosynthesis*; D002482:Cellulose / Q000378:metabolism; D004790:Enzyme Induction; D004794:Enzyme Repression; D005947:Glucose / Q000494:pharmacology
chemical_list: D002475:Cellobiose; D002482:Cellulose; D002480:Cellulase; D005947:Glucose