CSF levels of lactate and hydroxybutyrate dehydrogenase as indicators of neurological sequelae after neonatal brain damage.
A prospective study was made of levels of lactate and hydroxybutyrate dehydrogenase in the blood and cerebrospinal fluid of 57 term neonates, in relation to the time elapsed since delivery, neonatal examinations (Apgar score, neurological symptoms and EEG findings) and psychomotor outcome at one year of age. Serum determinations revealed no significant relationship with clinical assessments. CSF measurements showed significant differences near to the time of delivery between the normal and handicapped groups at age one, which supports the hypothesis of a causal link between neonatal brain damage and CSF enzyme levels.
D001927:Brain Diseases / Q000134:cerebrospinal fluid / Q000151:congenital / Q000201:enzymology*; D006801:Humans; D006884:Hydroxybutyrate Dehydrogenase / Q000097:blood / Q000134:cerebrospinal fluid*; D007231:Infant, Newborn; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000134:cerebrospinal fluid*; D009460:Neurologic Examination; D011446:Prospective Studies
D007770:L-Lactate Dehydrogenase; D006884:Hydroxybutyrate Dehydrogenase