[16,16-Dimethyl prostaglandin E2, human gastric potential difference and ethanol (author's transl)].
Experiments were performed in 8 healthy volunteers to determine the effect of graded doses of oral 16,16-dimethyl prostaglandine (PG) E2 on the ethanol-induced drop in gastric potential difference (PD). All doses of 16,16-dimethyl PG E2 between 1.0 and 20 micrograms did not prevent the initial fall in gastric PD induced by 48% ethanol. However, baseline PD-values recovered faster in the presence of 16,16-dimethyl PG E2. This effect was shown to be dose-dependent.
D015064:16,16-Dimethylprostaglandin E2 / Q000494:pharmacology*; D000328:Adult; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects*; D006801:Humans; D008564:Membrane Potentials / Q000187:drug effects; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*
D011459:Prostaglandins E, Synthetic; D000431:Ethanol; D015064:16,16-Dimethylprostaglandin E2
16,16-Dimethyl-prostaglandin E2 und transmuköse Potentialdifferenz beim Menschen. Ergebnisse mit Ethanol.