The effect of calcium, neostigmine and 4-aminopyridine upon respiratory arrest and depression of cardiovascular functions after aminoglycosidic antibiotics.
Neomycin causes arrest of peripheral respiration by blocking neuromuscular transmission by a presynaptic mechanism. It is not effective in the postsynaptic region until 14fold concentrations are used and it acts by a mechanism different from that of d-tubocurarine. Besides this, it has cardio-depressive effects. The common action of neomycin in all systems apparently concerns the movement of calcium across cell membranes. Calcium and 4-amino-pyridine act as antagonists of the curare-like activities of neomycin and its cardio-depressive action. Neostigmine is not an antagonist of these side-effects. 4-Aminopyridine is effective even in the case of calcium resistance which occurs after combination of several drugs related to neuromuscular transmission and neomycin.
D015761:4-Aminopyridine; D000617:Aminoglycosides / Q000037:antagonists & inhibitors; D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors*; D002118:Calcium / Q000494:pharmacology*; D003964:Diaphragm / Q000187:drug effects; D004347:Drug Interactions; D006439:Hemodynamics / Q000187:drug effects*; D009388:Neostigmine / Q000494:pharmacology*; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology; D051381:Rats; D012119:Respiration / Q000187:drug effects*
D000617:Aminoglycosides; D000631:Aminopyridines; D000900:Anti-Bacterial Agents; D009466:Neuromuscular Blocking Agents; D009388:Neostigmine; D015761:4-Aminopyridine; D002118:Calcium