title: Tyrosine increases blood pressure in hypotensive rats.
abstract: Administration of tyrosine, the amino acid precursor of catecholamines, increased blood pressure 38 to 49 percent in rats made acutely hypotensive by hemorrhage; other large neutral amino acids were ineffective. Tyrosine's effect was abolished by adrenalectomy, suggesting that, in hypotensive animals, it acts by accelerating the peripheral synthesis and release of catecholamines.
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002395:Catecholamines / Q000378:metabolism; D004195:Disease Models, Animal; D007022:Hypotension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D051381:Rats; D014443:Tyrosine / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D002395:Catecholamines; D014443:Tyrosine