Treatment of cystinuria with alpha-mercaptopropionylglycine.
Four cystinuric patients (3 females and 1 male) with recurrent L-cystine stone formation were treated with alpha-mercaptopropionyl glycine (MPG). In one patient the treatment was stopped because of a rash developing after one week of treatment. In the other 3 patients MPG was found to be as effective as penicillamine in lowering the urinary cystine excretion to safe levels. No serious side effects of the drug were recorded.
D000328:Adult; D000603:Amino Acids, Sulfur / Q000627:therapeutic use*; D003553:Cystine / Q000378:metabolism; D003555:Cystinuria / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D012008:Recurrence; D008625:Tiopronin / Q000009:adverse effects / Q000627:therapeutic use*; D014545:Urinary Calculi / Q000209:etiology
D000603:Amino Acids, Sulfur; D003553:Cystine; D008625:Tiopronin