Hemodynamic effects of rapid bolus hypertonic sodium bicarbonate.
We found that rapid bolus administration of hypertonic sodium bicarbonate in the recommended clinical dose produced significant, though transient, increases in intracranial pressure and decreases in blood pressure in dogs. These effects, which are related to the high osmolarity of the drug (2,000 mOsm/L), are not found when it is administered slowly.
D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects*; D006982:Hypertonic Solutions; D007275:Injections, Intravenous; D007427:Intracranial Pressure / Q000187:drug effects; D009994:Osmolar Concentration; D014655:Vascular Resistance / Q000187:drug effects
D001639:Bicarbonates; D006982:Hypertonic Solutions