Chronic inhalation study in rats, using cigarettes containing different amounts of Cytrel tobacco supplement.
The paper describes a chronic (18-month) inhalation study in rats, comparing respiratory tract lesions produced by exposures to cigarettes with different inclusions of Cytrel, a tobacco supplement. Histopathological examinations indicated lower responses in animals exposed to Cytrel-containing cigarettes than in those exposed to all-tobacco cigarettes, despite similar total deliveries of smoke. The decrease in response was approximately proportional to the level of Cytrel inclusion.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002482:Cellulose / Q000031:analogs & derivatives* / Q000633:toxicity; D005260:Female; D006801:Humans; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012137:Respiratory System / Q000187:drug effects / Q000473:pathology; D014029:Tobacco Use Disorder / Q000473:pathology
C012861:Cytrel; D002482:Cellulose