title: Acrylonitrile-14C metabolism in rats: effect of the route of administration on the elimination of thiocyanate and other radioactive metabolites in urine and feces.
abstract: In Wistar rats, the elimination of the sum of radioactive metabolites of acrylonitrile--14C was not markedly influenced by the rote of acrylonitrile administration. The elimination of thiocyanate, however, was significantly higher after oral (23% of the dose) than after intraperitoneal (4%), subcutaneous (4.6%), or intravenous (1.2%) administration. The elimination of the sum of radioactive metabolites was highest in the first 4 hours after acrylonitrile administration and rapidly decreased, whereas the excretion of thiocyanate reached maximum between hour 8 and 14 after oral or intraperitoneal administration. Less than 1% of radioactivity of the acrylonitrile--14C dose was eliminated in feces irrespective of the route of administration.
mesh_terms: D000181:Acrylonitrile / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D000284:Administration, Oral; D000818:Animals; D007271:Injections, Intradermal; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D009570:Nitriles / Q000378:metabolism*; D051381:Rats; D013861:Thiocyanates / Q000378:metabolism* / Q000652:urine
chemical_list: D009570:Nitriles; D013861:Thiocyanates; D000181:Acrylonitrile