Formation of thiazoles, thiazines, and thiadiazines from 1-phthalazine thiosemicarbazides as potential anticonvulsants.
3-Substituted-4-oxothiazolin-2-yl-(1-phthalazinyl)hydrazones, 3-substituted-4-oxo-5,6-dihydro-1,3-thiazin-2-yl-(1-phthalazinyl)hydrazones, and 2-substituted-amino-5-oxo-4-(1-phthalazinyl)-6-hydro-1,3,4-thiadiazines were prepared and tested for their anticonvulsant activity. Some compounds showed weak to moderate anticonvulsant activity.
D000818:Animals; D000927:Anticonvulsants; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D008722:Methods; D051379:Mice; D012663:Semicarbazides; D013829:Thiadiazines / Q000138:chemical synthesis / Q000494:pharmacology*; D013843:Thiazines / Q000138:chemical synthesis / Q000494:pharmacology*; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology*
D000927:Anticonvulsants; D012663:Semicarbazides; D013829:Thiadiazines; D013843:Thiazines; D013844:Thiazoles