title: Liver toxicity of ionic (Diatrizoate) and nonionic (C-29) contrast materials: effects of serum enzymes after hepatic artery injection in the rat.
abstract: Catheters were placed in the retrograde direction in the surgically exposed gastroduodenal arteries of rats. There was an early postoperative mortality of one-third of the animals. The catheter was exteriorized at the tail and was used for arterial perfusion of the liver with one experimental, nonionic contrast medium (C-29) and one ionic contrast medium (diatrizoate). Both contrast media (370 mg I/ml) were injected in a dose of 4 ml/kg rat. The contrast medium injections caused no significant changes in serum levels of the enzymes ALAT, ASAT, or GT.
mesh_terms: D000792:Angiography / Q000379:methods; D000818:Animals; D002404:Catheterization / Q000379:methods; D056486:Chemical and Drug Induced Liver Injury; D003287:Contrast Media / Q000009:adverse effects*; D003973:Diatrizoate / Q000008:administration & dosage / Q000009:adverse effects* / Q000633:toxicity; D004798:Enzymes / Q000097:blood; D006499:Hepatic Artery; D007269:Injections, Intra-Arterial; D007479:Iopamidol / Q000031:analogs & derivatives*; D007483:Iothalamic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*; D007928:Lethal Dose 50; D008297:Male; D051381:Rats
chemical_list: D003287:Contrast Media; D004798:Enzymes; D003973:Diatrizoate; D007483:Iothalamic Acid; C020687:C 29 (contrast media); D007479:Iopamidol