title: Application of twin flash stimuli for some mascular diseases isolation of local responses by twin flashes.
abstract: Double flash ERG was examined for patients with visual loss from macular and optic nerve disorders, and the responses were compared. K values (= (B1-B2))/B1 x 100) of the former were larger than normal values when the stimulus intervals were between 200 and 500 mseconds, and abnormality of K values seemed to correspond to the functional impairment of macula. On the other hand, K values of the patients with optic nerve diseases remained in the normal range. These facts indicate that double flash ERG is a very useful method to estimate the cone function clinically, and can be employed as a routine examination for patients with suspected cone dysfunction.
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D004558:Electric Stimulation; D004596:Electroretinography / Q000379:methods; D006801:Humans; D008266:Macula Lutea / Q000503:physiopathology*; D008268:Macular Degeneration / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D009896:Optic Atrophy / Q000175:diagnosis / Q000503:physiopathology*; D010786:Photoreceptor Cells / Q000503:physiopathology*; D014792:Visual Acuity