Treatment of Cushing's disease with bilateral adrenalectomy and autotransplantation.
2 Cases of childhood Cushing's disease have been treated with bilateral adrenalectomy and autotransplantation of adrenal tissue. Transplantation was unsuccessful in 1 case. In the other patient, replacement therapy was discontinued without any symptoms of hypo- or hyperadrenocorticism. Her urinary 17-hydroxycorticosteroids, free cortisol and aldosterone remain in the low normal range indicating functional adrenal tissue, probably a result of the transplant.
D000293:Adolescent; D000311:Adrenal Glands / Q000637:transplantation*; D000315:Adrenalectomy; D002648:Child; D003480:Cushing Syndrome / Q000378:metabolism / Q000601:surgery*; D005260:Female; D005938:Glucocorticoids / Q000378:metabolism; D006801:Humans; D014182:Transplantation, Autologous
D005938:Glucocorticoids