Effects of withdrawal from long-term diphenylhydantoin treatment on audiogenic and maximal electroshock-induced seizures in rats.
Rats withdrawal from long-term diphenylhydantoin treatment (DPH) were tested for their sensibility to convulsant stimuli. Animals were more sensitive to convulsions elicited by maximal electroshock and sound, respectively, at 48 and 72 h after drug removal. These results suggest that long-term DPH treatment might develop a central nervous system supersensitivity state.
D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D004597:Electroshock / Q000379:methods*; D008297:Male; D010672:Phenytoin / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012640:Seizures
D010672:Phenytoin