Simultaneous measurement of dothiepin and its major metabolites in plasma and whole blood by gas chromatography-mass fragmentography.
A method for the simultaneous measurement of dothiepin and two of its major metabolites, northiaden and dothiepin S-oxide in both plasma and whole blood is described. The method involves the use of gas chromatography-mass fragmentography. It is selective, sensitive (1 microgram/1) and reproducible. It has been used to analyse both plasma and blood samples following single oral doses of 75 mg dothiepin in seven volunteers.
D000328:Adult; D003988:Dibenzothiepins / Q000097:blood*; D004308:Dothiepin / Q000031:analogs & derivatives / Q000097:blood*; D004912:Erythrocytes / Q000032:analysis; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D008297:Male; D008832:Microchemistry; D010949:Plasma / Q000032:analysis
D003988:Dibenzothiepins; C030224:northiaden; C030226:dothiepin sulfoxide; D004308:Dothiepin