Pharmacological activity in the group of new pyrido-[2,3-c]-1,2 thiazine 1,1-dioxide derivatives.
Influence of 25 newly synthesized pyrido-1,2 thiazine 1,1-dioxide derivatives on immunological response and on induced inflammatory processes was studied. Marked immunostimulative activity (PFC) of 4,6-dimethyl-8-phenyl-2H-pyrido-[2,3-c]-thiazine dioxide (preparation X) was noted. Strong immunosuppressive activity connected with antiinflammatory activity (xylene, carrageenin and granulation test) was observed after the animals had been treated with 2-2'-(dimethyl-aminoethyl)-4,6-dimethyl-7-methoxy-8-phenyl-2H-pyrido-[2,3-c]-1, 2 thiazine 1,1-dioxide (preparation VIII) as well as 2,4,6-trimethyl-8-3H-thiazine dioxide (preparation XX). Mechanism of the activity of these compounds is discussed. In the group of the tested derivatives, relatively limited dependence between biological effects and chemical structure of the compounds was demonstrated.
D000276:Adjuvants, Immunologic; D000818:Animals; D000893:Anti-Inflammatory Agents; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D051381:Rats; D013843:Thiazines / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D000893:Anti-Inflammatory Agents; D013843:Thiazines