Local and systemic reactions to the parenteral administration of vitamin E.
Significant systemic toxicity has been observed in kittens daily with 50-1,000 mg/kg/day parenteral vitamin E for 3 weeks. The toxicity was dose-related and resulted in significant mortality at doses over 100-200 mg/kg daily. Local reactions to the injections could be eliminated by using the drugs intravenously or intraarterially as tested in acute and chronic preparation in the rat, rabbit and lamb.
D000818:Animals; D002415:Cats; D007263:Infusions, Parenteral; D007269:Injections, Intra-Arterial; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008099:Liver / Q000187:drug effects; D009929:Organ Size; D011817:Rabbits; D051381:Rats; D012756:Sheep; D014810:Vitamin E / Q000008:administration & dosage / Q000009:adverse effects*
D014810:Vitamin E