title: Arachidonate-induced experimental nerve infarction.
abstract: Despite the clinical importance of ischemia in the pathogenesis of many human neuropathies, little is known about the effect of circulatory compromise on the structure of peripheral nerves. This results in part from the lack of an entirely satisfactory model in which to study ischemic neuropathy. We therefore injected arachidonic acid, a potent stimulus to platelet aggregation and vasoconstriction, into the femoral artery of normal rats. This resulted in the rapid onset of focal infarction of the proximal posterior tibial nerve in all animals. Distally there was evidence of Wallerian degeneration but not of primary ischemic damage. The site and nature of the infarct and the temporal sequence of the pathological changes were highly consistent. This new method is a simple and highly reproducible means of producing experimental nerve infarction.
mesh_terms: D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D006614:Hindlimb / Q000098:blood supply; D006801:Humans; D007238:Infarction / Q000139:chemically induced* / Q000473:pathology; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D013979:Tibial Nerve / Q000098:blood supply* / Q000473:pathology; D014855:Wallerian Degeneration / Q000187:drug effects
chemical_list: D001095:Arachidonic Acids