title: Spectrum of haemolytic anaemias in Punjab, North India.
abstract: Between July 1974 and June 1978 the diagnosis of haemolytic anaemia was made in 267 patients. Thalassaemia major was the leading cause (40-50%) every year except in 1977, when a sharp rise in drug induced haemolysis in G-6-PD deficient patients (61.3%) was encountered. This was possible due to an increase in incidence of vivax malaria and the use of anti-malarial drugs in that year. Abnormal haemoglobins were noted in 9.7% of the total number of patients. Hereditary spherocytosis, autoimmune haemolytic anaemias and paroxysmal nocturnal haemoglobinuria formed a minor cause. Others included copper sulphate poisoning, snake bite, hornet sting and Plasmodium falciparum infection.
mesh_terms: D000293:Adolescent; D000328:Adult; D000745:Anemia, Hemolytic, Congenital / Q000139:chemically induced / Q000235:genetics*; D000962:Antimalarials / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005006:Ethnicity; D006580:Genetic Carrier Screening; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000235:genetics; D006455:Hemoglobins, Abnormal / Q000235:genetics; D006801:Humans; D007194:India; D013103:Spherocytosis, Hereditary / Q000235:genetics; D013789:Thalassemia / Q000235:genetics
chemical_list: D000962:Antimalarials; D006455:Hemoglobins, Abnormal