title: [Pharmacokinetics of 1-(4'-oxyphenyl)-2-(3'-phenyl-thiopropyl-amino) propane-1-01 hydrochloride (Istiod) in the rat].
abstract: The pharmacokinetics (serum, urinary and biliary concentrations) of Isotiod have been studied in rats. Doses exploited the property of the molecule in an alkaline medium with a diazonium salt to form coloured azo compounds. In rats Isotiod determines blood concentrations whose intensity and duration are proportional to the dose and route of administration; notable quantities of the drug are eliminated by the urinary way and a small quantity by the bile way with a personal technique.
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism; D007700:Kinetics; D008297:Male; D011412:Propanolamines / Q000378:metabolism*; D051381:Rats
chemical_list: D011412:Propanolamines; C005534:isotiod
vernacular_title: Indagini farmacocinesiche sul 1-(4'-ossifenil)-2-(3'-feniltiopropil-amino)-propano-1-olo cloridrato (Isotiod) nel ratto.