Alterations in glycoproteins and lipids in azaserine-induced acinar cell carcinoma of rat pancreas.
Glycoproteins and lipids of rat pancreatic acinar cell carcinomas maintained in nude mice and in cell culture, were analyzed. The tumor contained significantly elevated levels of glycoproteins when compared with their normal counterparts. SDS-PAGE of tumor glycoproteins revealed that there were increased amounts of small molecular weight glycoproteins and the tumor also contained a 51,000 dalton glycoprotein which was not detected in the pancreas, liver or the sera of the control animals. The tumor in nude mice and cancer cells in culture had decreased lecithins and triglycerides, and increased amounts of free fatty acids, and both free and esterified cholesterols. The results indicate that altered glycoprotein and lipid compositions represent some of the characteristic features of the acinar cell carcinoma.
D000818:Animals; D001377:Azaserine; D002277:Carcinoma / Q000032:analysis* / Q000139:chemically induced; D002478:Cells, Cultured; D002784:Cholesterol / Q000378:metabolism; D006023:Glycoproteins / Q000032:analysis*; D008055:Lipids / Q000032:analysis*; D008970:Molecular Weight; D010190:Pancreatic Neoplasms / Q000032:analysis* / Q000139:chemically induced; D051381:Rats
D006023:Glycoproteins; D008055:Lipids; D001377:Azaserine; D002784:Cholesterol