Effect of arginine infusion on endogenous pancreatic glucagon and gastric acid secretion in duodenal ulcer patients and normal subjects.
The effect of intravenous infusion of L-arginine on pentagastrin-stimulated gastric acid secretion was studied in 15 duodenal ulcer patients and 12 healthy subjects. In both groups L-arginine enhanced plasma concentrations of pancreatic glucagon equally and to levels similar to those seen after a protein-rich meal and inhibited the acid response in duodenal ulcer patients and in normal subjects. The study supports previous findings suggesting that pancreatic glucagon is a physiological inhibitor of gastric acid secretion but does not support the hypothesis of a defect in this inhibitory system in duodenal ulcer patients.
D000293:Adolescent; D000328:Adult; D000863:Antacids; D001120:Arginine / Q000008:administration & dosage*; D004381:Duodenal Ulcer / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D005934:Glucagon / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D010418:Pentagastrin / Q000494:pharmacology; D013268:Stimulation, Chemical
D000863:Antacids; D005934:Glucagon; D001120:Arginine; D010418:Pentagastrin