[Effect of certain chemicals on DNA synthesis and distribution in human transplantable gastrointestinal tumors].
beta-Spectrophotometry and cytophotometry were used to study the effect of 8 chemopreparations on the synthesis and distribution of DNA in human strains of colonic carcinoma (CC-I and CC-II), gastric carcinoma (GC) and liver carcinoma (LC) transplanted to thymectomized mice. Irrespective of no distinct correlation between clinical manifestations of the action of chemopreparations estimated from the tumor size in mice and the number and distribution pattern of DNA, the change in the latter two parameters indicates the tumor response to the chemopreparation.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D014183:Transplantation, Heterologous
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm
Vliianie nekotorykh khimiopreparatov na sintez i raspredelenie DNK v transplantiruemykh opukholiakh zheludochno-kishechnogo trakta cheloveka.