Polyamines in lymphomas: their value in disease staging and monitoring of therapy efficiency.
The urinary polyamines putrescine and spermindine were evaluated in a population of 49 patients with malignant lymphomas (40 with non-Hodgkin's lymphoma and 9 with Hodgkin's disease). Analyses were performed on a regular basis during the course of treatment. Polyamine levels were found to increase significantly with the disease stage. Results show that: (a) polyamines closely reflect disease evolution (clinical deterioration/clinical improvement); (b) comparison of polyamine measurements effected 24 h prior to and 48 h after initiation of a chemotherapy course allows evaluation of the response to treatment.
D002471:Cell Transformation, Neoplastic; D006801:Humans; D008137:Longitudinal Studies; D008223:Lymphoma / Q000188:drug therapy*; D009367:Neoplasm Staging; D011073:Polyamines; D011700:Putrescine / Q000652:urine; D013095:Spermidine / Q000652:urine
D011073:Polyamines; D013095:Spermidine; D011700:Putrescine