Ethanol-withdrawal syndrome associated with both general and localized increases in glucose uptake in rat brain.
Glucose uptake was studied in the brains of rats undergoing an overt ethanol-withdrawal syndrome by 2-deoxy-D-[14C]glucose autoradiography. In addition to a general increase in glucose uptake, localized alterations were observed in sensorimotor cortex, globus pallidus, thalamus and cerebellum. The results suggest that the ethanol-withdrawal syndrome is associated with a general increase in glucose metabolism as well as localized increases in functionally distinct regions of sensory and motor brain regions.
D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D001693:Biological Transport, Active; D001921:Brain / Q000378:metabolism*; D002250:Carbon Radioisotopes; D003847:Deoxyglucose / Q000378:metabolism; D000431:Ethanol / Q000009:adverse effects*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D000431:Ethanol; D003847:Deoxyglucose; D005947:Glucose