Amygdaloid kindling enhances the enkephalin content in the rat brain.
Established amygdaloid kindling causes an increase in the immunoassayable content of both Leuenkephalin and Met-enkephalin in the rat brain. Control and sham-operated (electrode implanted but not stimulated) rats do not show statistically significant differences in brain enkephalin content, while kindled rats show a 40% enkephalin increase in both hemispheres. The present finding is in agreement with several lines of evidence and suggest that enkephalins may play a role in epileptic seizures.
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004558:Electric Stimulation; D004723:Endorphins / Q000378:metabolism*; D004745:Enkephalins / Q000378:metabolism*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D012640:Seizures / Q000378:metabolism*
D004723:Endorphins; D004745:Enkephalins