Arrest of respiration induced by polypeptide antibiotics.
Polymyxin B affects neuromuscular transmission by blocking acetylcholine receptors. Its action is thus post-synaptic and the neuromuscular block has no antagonists. Polymyxin B causes neostigmine resistance to d-tubocurarine blockade and calcium resistance to the blockade evoked by aminoglycosidic antibiotics. Thus it increases the possibility of definitive arrest of respiration.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D002415:Cats; D003964:Diaphragm / Q000187:drug effects; D009355:Neomycin / Q000494:pharmacology; D009388:Neostigmine / Q000037:antagonists & inhibitors; D011112:Polymyxin B / Q000009:adverse effects / Q000494:pharmacology; D051381:Rats; D012119:Respiration / Q000187:drug effects*; D014403:Tubocurarine / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D009388:Neostigmine; D009355:Neomycin; D011112:Polymyxin B; D002118:Calcium; D014403:Tubocurarine