Serum vitamin E, lipid peroxide and glutathione peroxidase in patients with chronic pancreatitis.
It has been reported that lipid peroxidation increases in patients with antioxidant deficiencies, such as vitamin E and glutathione peroxidase. The relationships between serum lipid peroxide and vitamin E on the one hand and glutathione peroxidase on the other were examined in 22 patients with chronic pancreatitis, often accompanied by malabsorption of fats and fat-soluble vitamins due to the impaired exocrine pancreatic function. Both serum vitamin E concentrations and glutathione peroxidase activities were depressed, especially in patients with chronic calcifying pancreatitis. On the other hand, serum lipid peroxide levels were elevated. A significant negative correlation was found between the serum lipid peroxide levels and vitamin E concentration. These findings suggest than an elevation of the serum lipid peroxide level may be due to the lack of an antioxidative defense mechanism, such as vitamin E, against lipid peroxide.
D002908:Chronic Disease; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood*; D010544:Peroxidases / Q000097:blood*; D012016:Reference Values; D014810:Vitamin E / Q000097:blood*
D008054:Lipid Peroxides; D014810:Vitamin E; D010544:Peroxidases; D005979:Glutathione Peroxidase