Dapsone haemolysis in leprosy. A preliminary report.
Fifty one patients with leprosy from the Urban Leprosy Centre, attached to the Department of Dermatology and Venereology, Goa Medical College on treatment with Dapsone were studied from the point of view of development of haemolysis related to the drug. The findings are described and discussed. Anaemia developed in 60.7 percent of the patients during the course of treatment. It was mild and well compensated. The haemolytic effect of dapsone was related to the dose and duration of the treatment, being more manifested in doses above 50 mg daily.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000743:Anemia, Hemolytic / Q000139:chemically induced; D001663:Bilirubin / Q000097:blood; D002648:Child; D003622:Dapsone / Q000009:adverse effects*; D005260:Female; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D007918:Leprosy / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009996:Osmotic Fragility / Q000187:drug effects; D012156:Reticulocytes / Q000187:drug effects
D003622:Dapsone; D001663:Bilirubin