Evaluation of mixed venous oxygenation on the basis of arterial oxygen tension in chronic lung diseases.
The mixed venous oxygenation in relation to arterial oxygen tension was evaluated in the control group (30 subjects) and in patients with chronic obstructive lung disease (COLD; 56 subjects) and fibrosing alveolitis (FA; 20 subjects). The mixed venous hypoxia was found in 28.4% of patients with COLD and in 40% of patients with FA. The arterial oxygen tension values below which mixed venous hypoxia can be expected were below 55 mm Hg in normocapnic and below 46 mm Hg in hypercapnic patients. The values of mixed venous oxygen tension correlated significantly with the coefficient of oxygen delivery in the control group (r = 0.84; p less than 0.001) and in all patients taken together (r = 0.69; p less than 0.001). The finding of mixed venous hypoxia, which is an approximate index of tissue oxygenation, might have some clinical implications.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001158:Arteries / Q000378:metabolism; D002908:Chronic Disease; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000097:blood*; D008433:Mathematics; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D014680:Veins / Q000378:metabolism
D010100:Oxygen