Effect of tetracycline on adriamycin cardiotoxicity.
Male rats were treated with either adriamycin (2 mg/kg, i.v. weekly) or adriamycin and tetracycline (10 mg/kg, i.p., daily) for 8 weeks. Serum creatine phosphokinase (CPK) activity was measured after 8 weeks as an index of cardiotoxicity. Serum CPK was significantly elevated in the adriamycin-treated rats. Tetracycline failed to inhibit the adriamycin-induced increase in serum CPK. These results indicated that tetracycline does not prevent adriamycin-induced cardiotoxicity.
D000818:Animals; D003402:Creatine Kinase / Q000097:blood; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D006321:Heart / Q000187:drug effects*; D008297:Male; D051381:Rats; D013752:Tetracycline / Q000008:administration & dosage / Q000494:pharmacology*
D004317:Doxorubicin; D003402:Creatine Kinase; D013752:Tetracycline