Occupational exposure to N-nitroso compounds.
N-Nitrosodiphenylamine is used as an additive in the rubber industry. This N-nitrosamine has not been associated with carcinogenic effects in laboratory animals. However, it can serve as a powerful transnitrosation agent, reacting with amines present in the rubber mixture to form other N-nitrosamines; e.g., N-nitrosodibutylamine from di-n-butylamine and N-nitrosodimethylamine from tetramethylthiuram disulfide. Di-n-butylamine and tetramethylthiuram disulfide are both used as additives in the rubber industry.
D000393:Air Pollutants / Q000032:analysis*; D000395:Air Pollutants, Occupational / Q000032:analysis*; D002273:Carcinogens / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D007221:Industry; D009602:Nitrosamines / Q000032:analysis*; D009603:Nitroso Compounds / Q000032:analysis*; D011048:Polarography / Q000379:methods; D012408:Rubber; D013274:Stomach Neoplasms / Q000139:chemically induced
D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D002273:Carcinogens; D009602:Nitrosamines; D009603:Nitroso Compounds; D012408:Rubber; C023649:N-nitrosodiphenylamine