title: Vasopressin in the rat with partial nephrectomy-salt hypertension.
abstract: The role of vasopressin in the pathogenesis of partial nephrectomy (PN)-salt hypertension was examined in the rat. Hypertension was produced by reducing renal mass 70% and substituting 1% saline for drinking water 2 to 4 days after surgery. PN alone resulted in an increase in systolic blood pressure. Subsequent salt loading led to a further large increase in arterial pressure. On the second to third day after substitution of saline for drinking water, urinary vasopressin excretion (UADHV) was increased six-fold and the plasma vasopressin concentration was increased two and one-half-fold. UADHV then fell to a level that was three-fold greater than control values 5 days later. Although there was a marked stimulation of vasopressin release during the period of salt loading, a vasopressin pressor antagonist had only a small effect on arterial pressure. This suggests vasopressin is not a major pressor agent in PN-salt hypertension.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D004195:Disease Models, Animal; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D009392:Nephrectomy / Q000009:adverse effects*; D051381:Rats; D012965:Sodium Chloride / Q000009:adverse effects*; D014667:Vasopressins / Q000097:blood / Q000502:physiology* / Q000652:urine
chemical_list: D014667:Vasopressins; D012965:Sodium Chloride