Clastogenicity and aberration kinetics of some alkylarylnitrosoureas in Chinese hamster V79-E cells.
Six alkylarylnitrosoureas were checked for induction of chromosome aberrations and SCEs in Chinese hamster V79-E cells and compared with MNU, ENU and nitrosocarbaryl. All agents show a DNA-damaging activity. Studies of the dependence of aberration frequency on recovery time revealed drastic differences within this group of closely related substances.
D000818:Animals; D002273:Carcinogens; D002460:Cell Line; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D007700:Kinetics; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013329:Structure-Activity Relationship
D002273:Carcinogens; D009607:Nitrosourea Compounds