[Use of gestagens to control in vitro growth of endometrial carcinoma (author's transl)].
The impact of three gestagens, hydroxyprogesterone caproate, norethisterone acetate, and D-norgestrel, on in vitro cell cultures was tested in 40 test tubes and ten cover glasses. All tested cultures were of endometrial carcinomas. Cytomorphological changes were recordable from more than half of all cultures and interpreted as sensitivity to gestagens of the carcinoma concerned. No differences were safely established regarding effectiveness of different gestagens and different concentrations. In vitro gestagen action was clearly demonstrated by determination of nuclear overlap indexes of the cover glass cultures. No answer has yet been found as to whether reduction in nuclear overlap index, following addition of gestagens, had been caused by cellular modification. - Sensitivity of endometrial carcinoma to gestagens in vitro depended clearly on the degree of morphological differentiation.
D000077713:17 alpha-Hydroxyprogesterone Caproate; D002478:Cells, Cultured; D004351:Drug Resistance; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000627:therapeutic use; D009640:Norethindrone / Q000627:therapeutic use; D009644:Norgestrel / Q000627:therapeutic use; D011372:Progestins / Q000627:therapeutic use*; D014594:Uterine Neoplasms / Q000188:drug therapy*
D006908:Hydroxyprogesterones; D011372:Progestins; D000077713:17 alpha-Hydroxyprogesterone Caproate; D009644:Norgestrel; D009640:Norethindrone
Beeinflussung des In-vitro-Wachstums von Endometriumkarzinomen durch Gestagene.