title: [Thrombolytic therapy in a case of mitral valve thrombosis (author's transl)].
abstract: In this paper we present a case in which thrombolytic treatment with Streptokinase was successful in a 53-year-old patient, who developed valve thrombosis one year after aortic and mitral-valve replacement by Björk-Shiley tilding-disk-valve prosthesis. The patient suffered from pulmonary congestion and cardiogenic shock. In spite of Arterenol infusion the blood pressure fell down to 90/50 mm Hg. The systolic pulmonary artery-pressure rose up to 120 mm Hg, the cardiac output was 1.8 l/min. The patient became anuric. A transport to the next department of cardiovascular surgery was impossible. In this extraordinary critical situation for the patient we introduced a thrombolytic therapy with Streptokinase. Within a few hours, the systolic pulmonary artery-pressure fell down by 33%, the cardiac output increased by 100%. One and half days later the patient did not need Arterenol infusion and the blood pressure was 120/80 mm Hg. Referring to this observation, we conclude that Streptokinase therapy can be a successful emergency-treatment of a life-threatening artificial heart-valve thrombosis, if surgical treatment is impossible.
mesh_terms: D005260:Female; D006349:Heart Valve Diseases / Q000188:drug therapy; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve; D013300:Streptokinase / Q000627:therapeutic use*; D013927:Thrombosis / Q000188:drug therapy*
chemical_list: D013300:Streptokinase
vernacular_title: Streptokinasebehandlung einer Thrombose an einer Mitralklappenprothese.