title: [Cholesteatoma, oto- and tympanosclerosis: their general mechanism of tissue destruction (author's transl)].
abstract: The connective tissue contains extracellular enzymes for the turnover of the ground substance. If this enzyme system gets out of control there is development of a complex metabolic disturbance of all tissue components. The lysosomal dysfunction is the basis of the general mechanism of tissue destruction in cholesteatoma, oto- and tympanosclerosis. This process seems most enhanced in cholesteatoma. Emphasis is placed on the role of extracellular lysosomes (= matrix vesicles).
mesh_terms: D002781:Cholesteatoma / Q000473:pathology*; D003094:Collagen; D003238:Connective Tissue / Q000648:ultrastructure; D003599:Cytoskeleton / Q000648:ultrastructure; D004427:Ear Diseases / Q000473:pathology*; D004432:Ear, Middle / Q000473:pathology*; D006801:Humans; D008247:Lysosomes / Q000648:ultrastructure; D010040:Otosclerosis / Q000473:pathology*; D012598:Sclerosis
chemical_list: D003094:Collagen
vernacular_title: Cholesteatom, Oto- und Tympanosklerose: Ein gemeinsamer Mechanismus in der Gewebeschädigung.