The hypotensive effect of centrally administered tyrosine.
Intraventricular injection of 15 microgram L-tyrosine results in a significant reduction in blood pressure in the spontaneously hypertensive rat. An increase in the turnover of norepinephrine as indexed by MOPEG-SO4 is observed concurrently. The data are consistent with the previously suggested depressor role of certain central noradrenergic neurons.
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D006973:Hypertension / Q000188:drug therapy; D007276:Injections, Intraventricular; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D014443:Tyrosine / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology
D000959:Antihypertensive Agents; D014443:Tyrosine; D009638:Norepinephrine