Genetic linkage study of Duchenne muscular dystrophy and hemophilia A.
We studied a family in which three boys had both Duchenne muscular dystrophy and hemophilia A. Seven other males had only hemophilia A. Genetic linkage study showed a maximum likelihood estimate of recombination frequency of these two X-linked recessive traits of 0.16 with 95% confidence limits of 0.045 and 0.50. The loci of the two diseases may be closer than previous estimates.
D000293:Adolescent; D008040:Genetic Linkage; D006467:Hemophilia A / Q000150:complications / Q000235:genetics*; D006801:Humans; D008297:Male; D009136:Muscular Dystrophies / Q000150:complications / Q000235:genetics*; D011336:Probability