[Effect of local anesthetics on the transport of mannose in the microsomal membranes of Aspergillus niger van Tieghem].
The influence of various local anaesthetics has been studied on the mannose transfer enzymic system which is localized in Aspergillus niger van Tieghem microsomal membranes. The n-alkanes and tertiary amines do not seem to react on the first step of the reaction: i.e. the polyprenylphosphate-mannose biosynthesis. However two amines, the dibucaine and to a lesser extent the tetracaine, inhibit the mannose transfer from the polyprenylphosphate-mannose to the endogenous proteins.
D000473:Alkanes / Q000494:pharmacology; D000588:Amines / Q000494:pharmacology; D000779:Anesthetics, Local / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects / Q000201:enzymology*; D001692:Biological Transport / Q000187:drug effects; D007425:Intracellular Membranes / Q000201:enzymology*; D007700:Kinetics; D008358:Mannose / Q000378:metabolism*; D008861:Microsomes / Q000201:enzymology*
D000473:Alkanes; D000588:Amines; D000779:Anesthetics, Local; D008358:Mannose
Effet d'anesthésiques locaux sur le transfert de mannose dans les membranes microsomiques d'Aspergillus niger van Tieghem.