Radioimmunoassay of serum myoglobin in neuromuscular diseases.
Radioimmunoassay of serum myoglobin was performed in 85 patients with muscular symptoms. Elevated levels were found in 93% of patients with myogenic myopathy, in 54% with myasthenia gravis and in 50% with neurogenic myopathy. All 11 patients with polymyositis had elevated myoglobin concentrations. In six of seven patients with polymyositis, who were followed up with repeated determinations, a clear relationship between myoglobin levels and clinical course was found. In general serum myoglobin seemed to be a more sensitive indicator of muscle disease than creatine kinase.
D000328:Adult; D000368:Aged; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009133:Muscular Atrophy / Q000097:blood; D009136:Muscular Dystrophies / Q000097:blood; D009157:Myasthenia Gravis / Q000097:blood; D009211:Myoglobin / Q000097:blood*; D009220:Myositis / Q000097:blood; D009468:Neuromuscular Diseases / Q000097:blood*; D011863:Radioimmunoassay
D009211:Myoglobin; D003402:Creatine Kinase