Effect of single dose (1500 mg) rifampicin on infectivity of patients with lepromatous leprosy.
The effect of treatment with a single dose of Rifampicin (1500 mg) has been investigated in previously untreated lepromatous leprosy patients. A group of 14 cases were administered 1500 mg of Rifampicin in a single dose along with 100 mg Dapsone (DDS) daily. A control group received only 100 mg DDS daily. The patients were followed up for a period of 24 weeks. The clinical, bacteriological and results of mouse foot-pad inoculations do not indicate a significant advantage of the addition of a single dose of Rifampicin to the conventional therapy with DDA.
D000818:Animals; D003622:Dapsone / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007918:Leprosy / Q000188:drug therapy* / Q000382:microbiology; D051379:Mice; D012293:Rifampin / Q000008:administration & dosage*
D003622:Dapsone; D012293:Rifampin