Age-dependent changes in rat liver steroid hormone receptor proteins.
The formation of the steroid hormone-receptor protein complex in rat liver cytosol was investigated as a function of rat age. As reported earlier there was no age-related change in the concentration of receptor proteins in rat liver cytosol. The affinity of the specific receptor protein for both dexamethasone and corticosterone, however, decreased with age. An age-related decrease was observed in the concentration of steroid hormones that were associated with the specific receptor protein responsible for translocation of the nucleus. A reciprocal age-dependent increase in non-specific protein binding of the hormone occurred.
D000375:Aging; D000818:Animals; D003345:Corticosterone / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D003907:Dexamethasone / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D011485:Protein Binding; D051381:Rats; D011987:Receptors, Steroid / Q000032:analysis / Q000378:metabolism*
D011987:Receptors, Steroid; D003907:Dexamethasone; D003345:Corticosterone