Influence of dietary thiamine on pulmonary, renal, and hepatic drug metabolism in the mouse.
The effect of dietary thiamine status on the in vitro metabolism of drugs in mouse lung, kidney, and liver was investigated. Administration of a diet deficient in thiamine resulted in a tendency toward an elevated hepatic and pulmonary microsomal content of cytochrome P-450 and elevated activities of aminopyrine demethylase and aniline hydroxylase compared to those in similar mice fed 5 or 20 mg of thiamine per kilogram of diet. There was also a tendency for renal drug metabolism to be inversely related to dietary thiamine status. The effect of dietary thiamine on the induction of drug metabolism by phenobarbital in hepatic and extrahepatic tissues was also studied. In general, there was little to no difference in the percent induction as a function of thiamine status. These studies suggest that dietary thiamine is an important determinate in drug metabolism, and the metabolism varies with different tissues.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004032:Diet; D004347:Drug Interactions; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D010634:Phenobarbital / Q000494:pharmacology; D013831:Thiamine / Q000494:pharmacology* / Q000652:urine
D003577:Cytochrome P-450 Enzyme System; D013831:Thiamine; D010634:Phenobarbital