Convulsants (benzylpenicillin and pentylenetetrazol) on potential clamped myelinated axons from the rat.
The effect of two convulsants, benzylpenicillin and pentylenetetrazol, was tested in potential clamp experiments on single rat myelinated nerve fibres. 10 mM concentrations did not affect the permeability properties of the nodal membrane. The convulsive action is therefore probably not mediated through changes in the excitability of central axons.
D000818:Animals; D001369:Axons / Q000187:drug effects* / Q000502:physiology; D005260:Female; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009413:Nerve Fibers, Myelinated / Q000187:drug effects* / Q000502:physiology; D010400:Penicillin G / Q000494:pharmacology*; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects
D010400:Penicillin G; D010433:Pentylenetetrazole