Peptide segment coupling in aqueous medium: silver ion activation of the thiolcarboxyl group.
The use of the thiolcarboxyl function for the assemblage of deblocked peptide segments in aqueous medium has been investigated. The C-terminal thiolcarboxyl peptide Ac-Tyr-Arg-Arg-Glu-Arg-Gly-SH (2a) has been synthesized by the solid-phase method. The silver compound of peptide 2a was coupled to H-Phe-Ala-Glu-Gly-OH in 50% aqueous dimethylformamide to give a 40% yield of Ac-Tyr-Arg-Arg-Glu-Arg-Gly-Phe-Ala-Glu-Gly-OH.
D000595:Amino Acid Sequence; D009842:Oligopeptides / Q000138:chemical synthesis*; D012834:Silver
D009842:Oligopeptides; D012834:Silver; C030060:acetyltyrosyl-arginyl-arginyl-glutamyl-arginyl-thioglycyl