Salbutamol inhalation in chronic asthma bronchiale: dose aerosol vs jet nebulizer.
The effect of inhalation of 5 mg of salbutamol by a jet nebulizer and 0.3 mg from a metered aerosol was compared in 20 patients with chronic asthma. Half the patients, randomly selected, received one treatment method on day one and the other on day two. A battery of lung function tests suitable for detecting large and small airways obstruction showed only insignificantly more pronounced bronchodilatation after the use of the jet nebulizer. Neither was a better dilation of small airways with this method obvious. It is concluded that the higher dose by jet-nebulizer is only clinically motivated when the patients cannot perform the deep inhalations and breathholding necessary for efficient use of the dose aerosol.
D000328:Adult; D000336:Aerosols; D000368:Aged; D000420:Albuterol / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy*; D004304:Dosage Forms; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged
D000336:Aerosols; D004304:Dosage Forms; D000420:Albuterol