Synthesis of new psychotropic 2-imidazolidinones.
The report describes the synthesis and pharmacology of some new derivatives of 1-(m or p-chlorophenyl)-2-imidazolidinone. These compounds were obtained either by reacting an amine with an N-(2-chloroethyl)-2-imidazolidinone or by reacting a 2-chloroethylamine with an N-substituted-2-imidazolidinone. Two compounds (II f, h) showed interesting psychotropic activity.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000633:toxicity; D051381:Rats
D007093:Imidazoles; D011619:Psychotropic Drugs