title: Quantitative assessment of smooth-pursuit eye movements in healthy and epileptic subjects.
abstract: A quantitative electro-oculographic method was used to assess the impairment in smooth-pursuit and vestibulo-ocular reflex suppression eye movements in 12 epileptic patients and eight normal volunteers. Both types of eye movement were impaired by a factor of 40% in the epileptic patients, and the impairment was at least partly due to the treatment with phenytoin and phenobarbitone. There was a strong positive correlation between the performances in vestibulo-ocular reflex suppression and smooth-pursuit.
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects; D004585:Electrooculography; D004827:Epilepsy / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D005133:Eye Movements; D006801:Humans; D007360:Intelligence; D010634:Phenobarbital / Q000009:adverse effects; D010672:Phenytoin / Q000009:adverse effects; D012021:Reflex, Abnormal / Q000209:etiology*
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine; D010672:Phenytoin; D010634:Phenobarbital