[Pemphigus foliaceus in a child. A two years follow-up under steroid. An immunosuppression therapy (author's transl)].
The observation of pemphigus foliaceus out of endemic zone in a six-year-old child is reported. The rate of anti-ICS antibodies is very high (1/6,400). The direct immunofluorescence shows the common aspect of epidermic network between the cells. Fluorescence basement membrane has been found with monospecific anti-C3 sera, and after remission with the monospecific anti-IgG sera. The clinical, histological and immunological relationship between pemphigus foliaceus in its sporadic and endemic forms and pemphigus erythematosus are discussed. The clinical and immunological regression is obtained by association of prednisone and immunodepressive therapy. After two years of treatment the maintenance dosis is not yet reached. A review of ten previous reported cases of pemphigus foliaceus in children in its sporadic form is presented.
D000367:Age Factors; D002648:Child; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D010392:Pemphigus / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use*; D012737:Sex Factors
D011241:Prednisone
Pemphigus foliacé de l'enfant. Evolution sous corticothérapie et immunodépresseurs pendant deux ans.