title: Free-radical oxidation (peroxidation) products in serum and synovial fluid in rheumatoid arthritis.
abstract: Free-radical oxidation (peroxidation) products were measured in (a) 65 synovial effusions and (b) 30 sera from normal subjects and 58 sera from patients with rheumatoid arthritis (RA). Free-radical oxidation products were detectable in 90% of synovial fluids, their concentration being higher in "inflammatory" than in "degenerative" joint disease. Free-radical oxidation products in serum were significantly elevated in patients with RA compared to normal controls; the levels declined after treatment with a variety of antiinflammatory agents.
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D001769:Blood / Q000378:metabolism*; D003300:Copper / Q000378:metabolism; D005260:Female; D005453:Fluorescence; D005609:Free Radicals; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D013582:Synovial Fluid / Q000378:metabolism*; D014783:Viscosity
chemical_list: D005609:Free Radicals; D003300:Copper