title: Two children with cerebral gigantism and congenital primary hypothyroidism.
abstract: Two children are described in whom congenital primary hypothyroidism was associated with excessive growth during early childhood and who had typical morphological features of cerebral gigantism. One child was completely athyreotic. This association has been described previously in only one other child.
mesh_terms: D000365:Age Determination by Skeleton; D003409:Congenital Hypothyroidism; D003394:Craniofacial Dysostosis / Q000150:complications*; D005260:Female; D005877:Gigantism / Q000150:complications / Q000151:congenital*; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000188:drug therapy; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D013974:Thyroxine