Induction of colon tumors by a single oral dose of 1,2-dimethylhydrazine.
Male Fischer rats were treated at 7 weeks of age with a single oral dose of 1,2-dimethylhydrazine (35 mg/kg). After 1.5 years, the 14 control and 28 treated animals were killed for general autopsy. The incidence of tumor formation in the treated animals was 78.6% as compared to 0% for the control animals. All tumors (1--3/rat) were located in the colon, with the exception of one in the Zymbal's gland of the ear and one in the small intestine. The dosage of 1,2-dimethylhydrazine used in this study is the lowest single oral dose of this carcinogen reported to induce colon tumors.
D000284:Administration, Oral; D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced*; D004127:Dimethylhydrazines / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008763:Methylhydrazines / Q000008:administration & dosage*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D051381:Rats
D004127:Dimethylhydrazines; D008763:Methylhydrazines