[Cardiac function in transient coronary insufficiency after electrophoretic and injection methods of obsidan administration].
The peculiarities of the preventive use of obsidan administered by injection and electrophoresis were studied in experiments on rats with a model of transitory coronary insufficiency. A high efficacy of obsidan was demonstrated irrespective of the route of its administration into the body. This was manifested by a decrease in the rate of cardiac contractions in intact animals and depression of hyperkinetic cardiac reaction in the initial period of myocardial ischemia. The unfavourable inotropic and the antiarrhythmic effects of the agent were less in electrophoretic administration than in injection.
D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D003864:Depression, Chemical; D006321:Heart / Q000187:drug effects / Q000503:physiopathology*; D007267:Injections; D007478:Iontophoresis; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D011433:Propranolol / Q000008:administration & dosage*; D051381:Rats
D011433:Propranolol
Funktsiia serdtsa pri tranzitornoĭ koronarnoĭ nedostatochnosti v usloviiakh ĕlektroforeticheskogo i in'ektsionnogo metodov vvedeniia obzidana.