title: Early and late reactions in contact sensitivity in the mouse.
abstract: Several phases of plasma extravasation have been identified during the course of a contact sensitivity challenge reaction in mice. An early reaction at 1 h is seen which may be mast cell mediated. This is followed by the main phase of extravasation at 3-4 h. This phase is not seen in mice sensitized for less than 5 days and is transferable passively by serum. Between 8 and 15 h there is a prolonged period of moderately intense extravasation which represents the delayed hypersensitivity component of the reaction. Beyond 15 h there is virtually no further extravasation.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D003877:Dermatitis, Contact / Q000276:immunology*; D004423:Ear / Q000033:anatomy & histology; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007116:Immunization, Passive; D007457:Iodine Radioisotopes; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009929:Organ Size; D010081:Oxazolone / Q000494:pharmacology; D012709:Serum Albumin / Q000276:immunology; D012756:Sheep; D013997:Time Factors
chemical_list: D007457:Iodine Radioisotopes; D012709:Serum Albumin; D010081:Oxazolone