Conjugation of polyamines in mammalian cells in culture.
In cultures of BHK-21/C13 cells (Syrian baby hamster kidney fibroblasts) or 3T6 cells (Swiss mouse embryonic fibroblasts), spermidine and spermine undergo conjugation to a low molecular weight moiety which, under certain conditions, is excreted from cells into the extracellular fluid. A schematic model has been devised to describe the various metabolic processes that may be involved in the control of polyamine levels in mammalian cells and their extracellular fluid.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006224:Cricetinae; D004622:Embryo, Mammalian; D006151:Guanosine / Q000031:analogs & derivatives / Q000494:pharmacology; D007668:Kidney; D007700:Kinetics; D051379:Mice; D008935:Mitoguazone / Q000494:pharmacology; D011073:Polyamines / Q000378:metabolism*; D011700:Putrescine / Q000378:metabolism; D013095:Spermidine / Q000378:metabolism; D013096:Spermine / Q000378:metabolism; D013872:Thionucleosides / Q000494:pharmacology
D000970:Antineoplastic Agents; D011073:Polyamines; D013872:Thionucleosides; D006151:Guanosine; D013096:Spermine; C005783:6-thioguanosine; D008935:Mitoguazone; D013095:Spermidine; D011700:Putrescine