Comparative study of the secretory response to dopamine and seven amino acid conjugated derivatives on the blood-perfused canine pancreas.
The secretory responses to seven dopamine amino acid conjugated derivatives were compared with those to dopamine, using blood-perfused canine pancreas preparations. Each of these dopamine derivatives produced a dose dependent increase in the secretion of pancreatic juice. The rank order of the secretory responses and relative potency (dopamine = 1) was: N-Ileu-dopamine (0.4) greater than N-Ala-Glu-dopamine (0.2) greater than N-gamma-Glu-dopamine (0.1) = N-Gly-Pro-dopamine (0.1) greater than N-Gly-=Gly-dopamine (0.01) greater than N-Gly-Gly-Leu-dopamine (0.005) = N-Gly-Gly-Pro-dopamine (0.005). The duration of action of doses of the derivatives which produced approximately equal secretory responses was about 1.2--2.7 times longer than that of dopamine. Dopamine and N-Ileu-dopamine which has the most potent secretagogue property among seven dopamine derivatives produced a secretin-like secretion of the pancreatic juice containing a high concentration of bicarbonate but had little effect on protein output with lower amylase activity.
D000818:Animals; D004285:Dogs; D004298:Dopamine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism; D010477:Perfusion; D012633:Secretin / Q000494:pharmacology
D012633:Secretin; D004298:Dopamine