Bioavailability of propranolol in the dog.
The pharmacokinetics of propranolol in a fasted dog was examined following single oral, intraportal and intravenous doses. Extensive tissue uptake of propranolol occurred after intravenous dosing, the overall distribution volume was 11 liters/kg. Biological half-life was 1.5 hr, but was prolonged after oral and intraportal drug administration. Following oral doses, the absorption efficiency of propranolol as unchanged drug was 71%, while first-pass metabolism accounted for a further loss of 62% prior to its reaching the systemic circulation. Accordingly, the overall oral bioavailability was 27%.
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D004285:Dogs; D005260:Female; D007275:Injections, Intravenous; D007700:Kinetics; D011433:Propranolol / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
D011433:Propranolol