title: Enhanced polymorphonuclear chemotaxis - a common feature of diseases responsive to colchicine.
abstract: Increased chemotactic activity of peripheral polymorphonuclear (PMN) cells has been described in disease states of different etiology and may represent a common pathway in the generation of an inflammatory reaction. The suppressive effect of colchicine on PMN chemotaxis may explain its effect in apparently unrelated disorders.
mesh_terms: D001168:Arthritis / Q000188:drug therapy; D001528:Behcet Syndrome / Q000188:drug therapy; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D003078:Colchicine / Q000494:pharmacology* / Q000627:therapeutic use; D006073:Gout / Q000188:drug therapy; D006801:Humans; D007249:Inflammation; D009504:Neutrophils / Q000502:physiology*
chemical_list: D003078:Colchicine