[Pupillometry, a clinical pharmacological model / Relevance and limits (author's transl)].
A new non-invasive clinical pharmacological model, developed at the Institut für Klinische Pharmakologie, Bobenheim (FR Germany), is reported. The principle of the model is the photographic determination of the diameter of the pupilla before and after administration of drugs active at the pupillar muscle. The area of the pupilla as a parameter of drug effect can be proceeded mathematically. With the reported model the area under the time curve, the pupillary index and the mean myotic or mydriatic time is determined. The area under the curve gives information about the extent of the drug effect. The pupillary index takes the maximum diameter into account and is even more sensitive than the area under the curve, correcting steep and flat profiles of the time curve. The mean mydriatic or myotic time gives a robust measurement concerning the duration of the drug effect. To prove the relevance of our model we used N,N-diethyl-N-(2-[alpha-(tricyclo(2.2.1.02.6)hept-3-ylidene)-benzyloxy]-ethyl)- amine hydrochloride (treptilamine hydrochloride, Asta S 5521) in four different dosages orally and intravenously. The results show: 1. The model is appropriate to show the effect of drugs on the smooth pupillary muscle concerning rate and extent. 2. The drug treptilamine hydrochloride does change the diameter of the pupils. 3. The drug is active after oral application.
D000293:Adolescent; D000328:Adult; D001952:Bridged-Ring Compounds / Q000494:pharmacology; D005021:Ethylamines / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008954:Models, Biological; D009130:Muscle, Smooth / Q000187:drug effects; D009184:Mydriatics; D010781:Photography; D011680:Pupil / Q000187:drug effects*; D013997:Time Factors
D001952:Bridged-Ring Compounds; D005021:Ethylamines; D009184:Mydriatics; C021764:treptilamine
Die Pupillometrie, ein klinische-pharmakologisches Modell. Aussagekraft und Grenzen.