title: Role of antibacterial chemotherapy in the management of chronic bronchial obstructive disease.
abstract: Some aspects of antibiotic treatment in chronic bronchial obstructive disease are taken into consideration. The importance which can be attributed to the levels that antibiotics attain in bronchial secretions is discussed particularly as well as the factors which can influence them. The relevance of their adequate concentrations in bronchial secretions to the therapeutic results also is considered. The role which, in different ways, the behaviour of bacteria responsible for bronchial infections can play in conditioning the activity of antibacterial agents is another point that has attracted attention. The assessment of the importance that each one of these factors can have both in the development and in the treatment of the disease, as well as the integration of chemotherapy with other pharmacological and physiotherapic means, are the basis that will allow a more rational treatment of chronic bronchial obstructive disease.
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000517:prevention & control; D001980:Bronchi / Q000378:metabolism; D002908:Chronic Disease; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D013183:Sputum / Q000032:analysis
chemical_list: D000900:Anti-Bacterial Agents