Chronic alcohol consumption increases cyclo (His-Pro)-like immunoreactivity in the rat brain.
Administration of histidyl-proline diketopiperazine (cyclo (His-Pro)) to rats attenuates ethanol-induced sleep. To understand the role played by cyclo (His-Pro) in the pathophysiology of prolonged alcohol consumption, we have measured the distribution of this peptide in brains of control and alcohol-treated rats. The data show that prolonged alcohol consumption increases the concentration of cyclo (His-Pro) in hypothalamic as well as extrahypothalamic brain. These changes may reflect a physiologic adaptation of the brain during alcohol consumption.
D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D009928:Organ Specificity; D010456:Peptides, Cyclic / Q000378:metabolism*; D010879:Piperazines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D010456:Peptides, Cyclic; D010879:Piperazines; C015924:histidyl-proline diketopiperazine