Levels of prostaglandin F2 alpha, E2 in the human uterine tissues and in human fallopian tubes from nonpregnant women.
Tissue samples were obtained from 30 women between the ages 16 and 44 with normal regular menstrual cycles, from 30 women between the ages 31 and 52 with uterine myoma, and from 4 women between the ages 37 and 58 with uterine cervical carcinoma in situ (Abb. CIS). The levels of prostaglandins (Abb. PGs) were determined by radioimmunoassay (Abb. RIA), and PGEs were identified and assayed by gas chromatography mass spectrometry (Abb. gas-mass). Levels of PGF2 alpha and E2 in normal menstrual cycles changed periodically as previously reported. The levels of PGF2 alpha and E2 in the uterine tissues from the women with uterine myoma were significantly highest in the endometrium, and were higher in the uterine cervix than in the uterine corpus. Those in the Fallopian tubes were higher at the ampullar region than at the isthmic one. The levels of PGs by the method of gas-mass in the uterine tissues and in the Fallopian tubes were almost the same as those determined by RIA. Though PGE1 and PGE2 existed, PGE3 could not be detected. PGs play important roles in reproduction.
D000293:Adolescent; D000328:Adult; D005187:Fallopian Tubes / Q000032:analysis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009214:Myoma / Q000032:analysis; D011458:Prostaglandins E / Q000032:analysis*; D011460:Prostaglandins F / Q000032:analysis*; D011863:Radioimmunoassay; D014594:Uterine Neoplasms / Q000032:analysis; D014599:Uterus / Q000032:analysis*
D011458:Prostaglandins E; D011460:Prostaglandins F