The thrombo-embolic disease as a paraneoplastic syndrome.
Out of 4139 patients autopsied, 629 had the thrombo-embolic disease (15.2%). 548 patients suffered from various malignancies, and among them 102 (19.9%) had the thrombo-embolic disease as well. Only 5 patients with the thrombo-embolic disease had an occult malignoma. The increased incidence of the thrombo-embolic disease in patients suffering from various types of malignancies is statistically significant (0.05 less than p greater than 0.02). The interceptibility of the paraneoplastic thrombo-embolic disease at the hospital departments is very low when compared to necropsy (about 3%) but, on the other hand, in more than one half of all cases studied it represents the first clinical symptoms of a malignoma, though rarely evaluated correctly. The clinico-pathologic aspects of the paraneoplastic thrombo-embolic disease are discussed.
D005260:Female; D005770:Gastrointestinal Neoplasms / Q000150:complications; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D013923:Thromboembolism / Q000209:etiology*; D014565:Urogenital Neoplasms / Q000150:complications