[Effect of orotic acid, calcium pangamate, and lipamide on ultrastructural changes in lipocytes in hepatic dystrophy].
Experiments on 50 albino rats with liver dystrophy caused by carbon tetrachloride have shown that orotic acid calcium pangamate and lipamide decrease the damage to subcellular structures of hepatocytes, favour normalization of cytoplasmatic cell components. Combined use of orotic acid and calcium pangamate was found to promote more positive effect on membranous constituents and hyperplastic processes in liver parenchymal cells as compared with the effect that might be attained by applications of the drugs alone. The combined use of the drugs is also conducive to more intensive intracellular reparative regeneration.
D000818:Animals; D002125:Calcium Gluconate; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D008099:Liver / Q000648:ultrastructure*; D008854:Microscopy, Electron; D034442:N-substituted Glycines; D009963:Orotic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D011437:Propylamines; D051381:Rats; D014803:Vitamin B Complex / Q000008:administration & dosage / Q000627:therapeutic use*
D034442:N-substituted Glycines; D011437:Propylamines; D014803:Vitamin B Complex; D009963:Orotic Acid; C105565:pangamic acid; D002125:Calcium Gluconate
Vliianie orotovoĭ kisloty, pangamata kal'tsiia i lipamida na ul'trastrukturnye izmeneniia gepatotsitov pri distrofii pecheni.