[Triglyceride secretion of the rat liver under various conditions of fool-induced obesity].
The secretion rates of triglycerides from liver into plasma of obese animals and controls, as well as in obese animals 4 weeks from feeding a fat-deprived diet were determined. In the dynamic phase of obesity (9-week-old animals receiving fat-rich food for 4 weeks) an increase in secretion rate over the control was determined, which persisted to the same extent after having fed a fat-deprived diet for 4 weeks. In the static phase of obesity (24-week-old animals given a fat-rich diet for 9 weeks) the control animals showed the same secretion rate as the control animals in the dynamic phase. In contrast to the dynamic phase, obese animals revealed no changes of the secretion rate also in these animals. Since the present knowledge about the regulation of triglyceride release from the liver into the plasma via the VLDL is scarce, various food-, hormone-, and enzyme effects have been discussed in more detail, and the changes observed were correlated, on the basis of own experiments, in particular with hyperinsulinemia present in the obese animals and with the increased supply of free fatty acids to the liver in the dynamic phase of obesity. The changes in secretion rate following the shift to fat-deprived food cannot at present be satisfactorily explained.
D000818:Animals; D001835:Body Weight; D004041:Dietary Fats / Q000008:administration & dosage*; D008079:Lipoproteins, VLDL / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D009765:Obesity / Q000209:etiology / Q000378:metabolism*; D051381:Rats; D014280:Triglycerides / Q000378:metabolism*
D004041:Dietary Fats; D008079:Lipoproteins, VLDL; D014280:Triglycerides
Triglyzeridsekretion der Rottenleber unter verschiedenen Bedingungen einer nahrungsinduzierten Fettsucht.