Inhibition of lymphocyte activation by hatching fluid from Schistosoma mansoni eggs.
A preparation of the fluid released upon hatching of the miracidia from Schistosoma mansoni eggs was found to have a potent inhibitory effect on the in vitro activation of hamster lymphocytes by mitogens. The effect was concentration dependent, not cytotoxic, and was the same on cells from healthy and schistosome-infected animals.
D000818:Animals; D006224:Cricetinae; D005260:Female; D008213:Lymphocyte Activation; D008647:Mesocricetus; D008934:Mitogens / Q000494:pharmacology; D010063:Ovum / Q000276:immunology; D012550:Schistosoma mansoni / Q000276:immunology*; D012552:Schistosomiasis / Q000276:immunology*
D008934:Mitogens