Relaxin purification from human placental basal plates.
A crude relaxin preparation has been obtained from the basal plate region of electric cesarean section human placentae, as well as normal term placentae. The relaxin isolated has different charge properties by ion exchange chromatography from porcine relaxin, although it is of approximately the same molecular size. The most potent fraction obtained has approximately 0.7% of the immunoactivity of purified porcine relaxin when compared with porcine relaxin in a RIA based on porcine material, suggesting significant amino acid sequence differences between the putative human relaxin and its porcine counterpart.
D000818:Animals; D001681:Biological Assay; D002585:Cesarean Section; D005260:Female; D006801:Humans; D007118:Immunoassay; D051379:Mice; D010920:Placenta / Q000032:analysis*; D011247:Pregnancy; D012065:Relaxin / Q000302:isolation & purification* / Q000494:pharmacology; D014599:Uterus / Q000187:drug effects
D012065:Relaxin