Threshold sensitivity of the auditory pathway: effects of worsening signal-to-noise ratio in the auditory nerve.
Perfusions of scala tympani with high potassium solutions increase spontaneous activity of auditory nerve fibres without affecting their threshold sensitivity. In these circumstances, however, the signal-to-noise ratio of the auditory nerve response to a given stimuli is worsened. Recordings from cochlear nucleus neurones during such perfusions indicate that this worsening is critical for threshold sensitivity at higher levels in the auditory pathway.
D000161:Acoustic Stimulation; D000818:Animals; D001306:Auditory Pathways / Q000502:physiology*; D001309:Auditory Threshold / Q000187:drug effects / Q000502:physiology*; D003056:Cochlear Nerve / Q000502:physiology; D006168:Guinea Pigs; D009412:Nerve Fibers / Q000502:physiology; D010477:Perfusion; D011188:Potassium / Q000494:pharmacology; D012533:Scala Tympani; D000159:Vestibulocochlear Nerve / Q000502:physiology*
D011188:Potassium