[Immunity reaction in old age (author's transl)].
In 20 persons in old age and in 20 young persons the immunization with 0,5 ml of a vaccine (tetanus toxoid) was performed. The cell--immediated immunity of lymphocytes of these probands were investigated on the 0,7 21. and 28. day by lymphocyte-transformation test and E-rosette test. The boostering followed after 21 days with the same dose of the vaccine. It was found that the spontaneous transformation rate in T-lymphocytes in old age compared to the young age was duplicated. The stimulation with PHA (Phytämagglutinin) showed no significant differences while the specific cellular reactivity of the T-cells in old age is delayed and reduced compared to the T-cells in young age.
D000293:Adolescent; D000328:Adult; D000368:Aged; D006801:Humans; D007111:Immunity, Cellular; D007114:Immunization; D008213:Lymphocyte Activation; D008297:Male; D012397:Rosette Formation; D013745:Tetanus Toxoid / Q000276:immunology*
D013745:Tetanus Toxoid
Zum Immunitätsverhalten im Alter. 2. Mitteilung: Zur zellvermittelten Immunität bei Menschen im höheren Lebensalter nach aktiver Immunisierung mit einem Tetanus-Adsorbatimpfstoff.