title: Action of GABA and glycine on the membrane potential of culture astrocytes and the extracellular concentration.
abstract: The depolarization of cultured astrocytes by GABA and glycine correlates in amplitude and time course with the increase of the extracellular K+ -concentration during perfusion with these amino acids. It is suggested that the glial depolarization is caused by an efflux of K+ from neighbouring neurones activated by the amino acid transmitters.
mesh_terms: D000409:Alanine / Q000494:pharmacology; D000818:Animals; D001253:Astrocytes / Q000187:drug effects*; D002478:Cells, Cultured; D004553:Electric Conductivity; D005110:Extracellular Space / Q000378:metabolism; D005998:Glycine / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects*; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D013654:Taurine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
chemical_list: D013654:Taurine; D005680:gamma-Aminobutyric Acid; D000409:Alanine; D011188:Potassium; D005998:Glycine