Persistence of the anti-cholinesterase soman in rats; antagonism with a non-toxic simulator of this organophosphate.
Anaesthetized, atropinized rats were poisoned with 6x LD50 soman (1,2,2,-trimethylpropyl methylphosphonofluoridate). Purified acetylcholinesterase, injected i.v. 75 min later, was rapidly inhibited, presumably by soman stored in a 'depot' from which it was gradually released. Existence of a depot is supported by the effect of a soman-simulator ('som-sim'), an organophosphonate structurally similar to soman but devoid of anti-cholinesterase activity. Som-sim can expel soman from the depot, or counteract its formation. Som-sim prophylaxis greatly enhances survival.
D000110:Acetylcholinesterase; D000818:Animals; D008297:Male; D009943:Organophosphorus Compounds / Q000378:metabolism*; D010091:Oximes; D011726:Pyridinium Compounds; D051381:Rats; D012999:Soman / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013997:Time Factors
D009943:Organophosphorus Compounds; D010091:Oximes; D011726:Pyridinium Compounds; D012999:Soman; D000110:Acetylcholinesterase; C022870:asoxime chloride