title: Human liver aldehyde dehydrogenase in Chinese and Asiatic Indians: gene deletion and its possible implications in alcohol metabolism.
abstract: Two separate human liver aldehyde dehydrogenases exist which show differences in substrate specificity, cation inhibition or activation, and molecular weight. In this paper we report a common absence of enzyme 2 in Chinese which may be taken to indicate a gene deletion coding for this enzyme. The possible implication of thie gene deletion among Chinese is discussed.
mesh_terms: D000444:Aldehyde Dehydrogenase; D000445:Aldehyde Oxidoreductases / Q000172:deficiency / Q000235:genetics*; D044466:Asian People; D002681:China / Q000208:ethnology; D002872:Chromosome Deletion; D006801:Humans; D007194:India / Q000208:ethnology; D007526:Isoelectric Point; D008099:Liver / Q000201:enzymology*; D008970:Molecular Weight; D013379:Substrate Specificity
chemical_list: D000445:Aldehyde Oxidoreductases; D000444:Aldehyde Dehydrogenase