Sulphonamide as hemolysis-promoting factor in uremia.
Nine out of 39 uremic patients treated with sulphonamides because of urinary tract infection developed hemolysis. Heinz-bodies were seen in all cases. In uremic patients a defect of the HMP metabolic pathway renders these patients susceptible to hemolysis when treated with oxidant drugs.
D006366:Heinz Bodies / Q000032:analysis; D006463:Hemolytic-Uremic Syndrome / Q000139:chemically induced*; D006801:Humans; D013449:Sulfonamides / Q000009:adverse effects*; D014511:Uremia / Q000150:complications* / Q000378:metabolism; D014552:Urinary Tract Infections / Q000188:drug therapy*
D013449:Sulfonamides