title: Infusions of minaxolone to supplement nitrous oxide-oxygen anaesthesia. A comparison with althesin.
abstract: In 19 patients, minaxolone citrate, a water-soluble steroid anaesthetic agent, has been used as a continuous infusion to supplement nitrous oxide anaesthesia. The minimum infusion rate (MIR) was found to be 11.3 micrograms kg-1 min-1 for patients premedicated with morphine 10 mg i.m. and breathing spontaneously 66% nitrous oxide in oxygen. The cardiovascular and respiratory effects were similar to those described in a previous study for Althesin administered under comparable conditions. Recovery from minaxolone was prolonged compared with Althesin, and this may be related both to the water-solubility of the drug, and to its greater apparent volume of distribution.
mesh_terms: D000328:Adult; D000368:Aged; D000530:Alfaxalone Alfadolone Mixture / Q000097:blood / Q000494:pharmacology; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology; D001784:Blood Gas Analysis; D004569:Electroencephalography; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007263:Infusions, Parenteral; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide; D010100:Oxygen; D011278:Pregnanes / Q000008:administration & dosage*; D011280:Pregnanolone / Q000008:administration & dosage* / Q000031:analogs & derivatives; D012119:Respiration / Q000187:drug effects
chemical_list: D000777:Anesthetics; D011278:Pregnanes; C020413:minaxolone; D000530:Alfaxalone Alfadolone Mixture; D011280:Pregnanolone; D009609:Nitrous Oxide; D010100:Oxygen