Hemoglobin Yusa (beta 21 (B3) Asp leads to Tyr), a new abnormal hemoglobin found in Japan.
An electrophoretically slowly moving hemoglobin variant, Hb Yusa, was found in a 48-year-old man, his younger sister and mother. No clinical or hematological abnormalities were seen in the individuals heterozygous for this mutant gene. Structural studies of this abnormal hemoglobin showed a new type substitution of beta 21 (B3) Asp leads to Tyr. The percentage of the abnormal hemoglobin in the hemolysate was 40.8. The hemoglobin had neither instability nor functional abnormality.
D000596:Amino Acids / Q000032:analysis; D001224:Aspartic Acid; D005260:Female; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D007525:Isoelectric Focusing; D007564:Japan; D008297:Male; D008875:Middle Aged; D010108:Oxyhemoglobins / Q000378:metabolism; D010446:Peptide Fragments / Q000032:analysis; D014443:Tyrosine
D000596:Amino Acids; D006455:Hemoglobins, Abnormal; D010108:Oxyhemoglobins; D010446:Peptide Fragments; D001224:Aspartic Acid; D014443:Tyrosine; C029515:hemoglobin Yusa