Nifedipine and left ventricular function in beta-blocked patients.
We studied the acute effects of nifedipine on left ventricular function and haemodynamics at constant heart rate in patients on beta-blocker therapy. Nifedipine significantly depressed left ventricular peak dP/dt and peak dP/dt x P-1. Nifedipine also significantly reduced systemic vascular resistance: this was associated with decreased systolic blood pressure and increased left ventricular stroke output, with slight non-significant increases of ejection fraction and mean circumferential shortening velocity. There was no change in left ventricular end-diastolic pressure. This clinical study shows that nifedipine increases cardiac output in association with arterial dilatation despite evidence for a negative inotropic effect. Such intrinsic negative inotropic effects would normally be masked by compensatory sympathetic activity.
D001262:Atenolol / Q000627:therapeutic use*; D003864:Depression, Chemical; D005260:Female; D006321:Heart / Q000187:drug effects / Q000503:physiopathology*; D006352:Heart Ventricles / Q000187:drug effects / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology*; D011412:Propanolamines / Q000627:therapeutic use*; D011725:Pyridines / Q000494:pharmacology*; D013564:Sympathetic Nervous System / Q000503:physiopathology
D011412:Propanolamines; D011725:Pyridines; D001262:Atenolol; D009543:Nifedipine