Effect of daunomycin on myocardial contractility and on the action of beta-methyldigoxin.
In isolated electrically driven guinea pig left atria daunomycin at concentrations of 50-200 microgram/ml reduced the contraction. In the presence of daunomycin the positive inotropic effect of beta-methyldigoxin was reduced and, at higher concentration of daunomycin, contractility was inherited.
D000818:Animals; D003630:Daunorubicin / Q000494:pharmacology*; D004077:Digoxin / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D008520:Medigoxin / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*
D004077:Digoxin; D008520:Medigoxin; D003630:Daunorubicin