[Pharmacokinetics of a new antibiotic preparation, novoolean].
We studied the resorption, the distribution, the duration of retention, as well as the routes of elimination by the organism of the complex antibiotic medicine (novobiocin salt of the oleandomycin). It was proved that after a single muscular injection of doses 20 and 50 mg/kg t the medicine, unlike its constituting components, possesses a retained action and keeps up bacteriostatic concentrations of blood in sheep, rabbits and chickens for a period of 12, respectively 24 hours. No substantial differences were observed between the blood levels created of the different species after the use of equal doses. No resorption was observed (or practically an insignificant one) in the digestive tract of rabbits. After its resorption from the place of its application the 'novoolean' penetrates into all organs studied, tissues and liquids of the organisms of guinea pigs, except for the brain. The longest period of retention is that in the lungs and in the kidneys. It is eliminated by the organism mainly through the urine and the bile secretion, and in the case of the lactating mammals-through the milk. The organism of the treated animals is practically free from 'novoolean' after the fourth day and as to the milk--after the second day of the last intramuscular injection.
D000284:Administration, Oral; D000818:Animals; D002645:Chickens; D004338:Drug Combinations; D007273:Injections, Intramuscular; D007700:Kinetics; D009675:Novobiocin / Q000378:metabolism*; D009827:Oleandomycin / Q000378:metabolism*; D011817:Rabbits; D012756:Sheep; D013997:Time Factors; D014018:Tissue Distribution
D004338:Drug Combinations; D009675:Novobiocin; D009827:Oleandomycin
Farmakokinetika na noviia antibiotichen preparat novoolean.