[Discordance and variability in the clinical picture of schizophrenia in hereditarily loaded families].
On the basis of comparing the clinical forms of schizophrenia in 132 "parents--children" pairs and 104 pairs of sibs (of 200 families with aggravated heredity) the authors have shown that the discordance phenomenon is associated with the characteristics of the catatonic and simple forms of schizophrenia and the periodic and paroxysmal course of the process, the facts, that prove the phylogenetic connection of the forms and types of the schizophrenia course. The discordance data are in agreement with a chronological random analysis of the schizophrenia diagnoses (with regard to the forms of the disease and the type of its course) made in 1961 to 1976 The diminution of the number of patients with the paroxysmal course of the process and with the catatonic form observed in the last years can be understood from the standpoint of the evolutionary-genetic hypothesis of schizophrenia.
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000235:genetics*; D012560:Schizophrenia, Catatonic / Q000235:genetics; D012562:Schizophrenia, Disorganized / Q000235:genetics; D012563:Schizophrenia, Paranoid / Q000235:genetics
Diskordantnost' i variabel'nost' kliniki shizofrenii v nasledstvenno otiagoshchennykh sem'iakh.