Effect of smoking on the elimination of propranolol hydrochloride.
The effect of smoking on the elimination characteristics of propranolol was determined in 20 patients, 10 smokers and 10 non-smokers, who were taking the drug on a continual basis. Smokers took larger doses than non-smokers. The apparent body clearance (ABC) of propranolol in the smoking group was significantly greater than in the non-smoking group (p less than 0.01). When the serum concentrations were adjusted for body weight and dose, the non-smoking group had significantly higher serum concentrations than did the smoking group. The values for half-live (t 1/2) and elimination (k) demonstrated a trend toward a decreases in t 1/2 and increase in k in the group of smokers.
D000328:Adult; D000367:Age Factors; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011433:Propranolol / Q000378:metabolism*; D014029:Tobacco Use Disorder / Q000378:metabolism*
D011433:Propranolol