[Neurological tolerance of lithium-psychotropic drugs association (author's transl)].
The authors have studied the neurological tolerance from the combination of lithium-psychotropic drugs from 265 associated cures carried out on 132 patients between 1971 and 1978. The risk of neurological inability to assimilate is not greater when haldol is combined with lithium by comparison with other combinations where it is not included. Only the presence of cerebral organicity presents a risk factor. The 117 associated cures were preceded by preliminary treatments during which either the lithium or the psychotropic drugs were used to the same extent during the treatment. This series seems to allow on one hand to demonstrate that the incidence of neurological signs is multiplied by two by the combination, on the other hand to note that the intensity of the neurotoxic effects increases.
D000328:Adult; D000368:Aged; D003221:Confusion / Q000139:chemically induced; D004359:Drug Therapy, Combination; D005260:Female; D006220:Haloperidol / Q000009:adverse effects; D006801:Humans; D008094:Lithium / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced*; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000009:adverse effects*
D011619:Psychotropic Drugs; D008094:Lithium; D006220:Haloperidol
Tolerance neurologique de l'association lithium-psychotropes. A partir de 265 cures associatives.