The parietal cells in duodenal ulcer patients. A quantitative ultrastructural study before and during treatment with cimetidine.
Quantitative ultrastructural analyses of the parietal cells have been performed on eleven patients with chronic duodenal ulcer, before and after 8 weeks' treatment with a histamine H2-receptor antagonist (cimetidine, 1 g/day). The treatment caused a significant decrease of the secretory surface density; this result seems to differ from those of ultrastructural reports on parietal cells when acid secretion is inhibited by vagotomy. Furthermore, it was demonstrated that the profile of the tubulo-vesicles of parietal cells could be seen in three phases, tentatively suggesting that this system is able to take up material from the surrounding cytoplasm by encircling it.
D000328:Adult; D002908:Chronic Disease; D002927:Cimetidine / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000473:pathology; D004386:Duodenum / Q000187:drug effects / Q000648:ultrastructure*; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged
D006146:Guanidines; D002927:Cimetidine