Effect of iron poly (sorbitolgluconic acid) complex on urinary cellular excretion.
The intramuscular injection of 250 mg iron poly (sorbitol-gluconic acid) complex caused no increase in urinary cellular or bacterial excretion in 8 patients with chronic pyelonephritis, 4 patients with non-infective renal disease, and 4 controls. However, in 4 patients with chronic infective disease of the renal tract given 500 g there was a significant increase in cellular excretion. This response was not seen in 2 control patients, nor in 2 patients with non-infective renal disease. Using a differential staining technique, this increase in urinary cellular excretion was found to be due, not to leucocytes, but to renal tubular cells. The precise significance of this is unclear, but there would be concern that the high concentration of excreted iron was providing a 'toxic' insult to susceptible, infection-damaged cells.
D005942:Gluconates / Q000494:pharmacology; D006801:Humans; D007501:Iron / Q000494:pharmacology*; D007674:Kidney Diseases / Q000652:urine; D009942:Organometallic Compounds; D011704:Pyelonephritis / Q000652:urine; D013012:Sorbitol / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors; D014556:Urine / Q000166:cytology*
D005942:Gluconates; D009942:Organometallic Compounds; D013012:Sorbitol; C021677:iron-poly(sorbitol-gluconic acid) complex; D007501:Iron