[Normalization of lipid levels in an 87-year-old woman with a type III dysbetalipoproteinemia by ethinyl estradiol (author's transl)].
An 87-year-old women with a type III hyperlipoproteinemia previously known as good clofibrate responder, was treated with oral doses of 50 and then 25 microgram/day of ethinyl estradiol for 6 weeks. Lipid levels were almost normal after one week of therapy, but increased again as soon as treatment was discontinued. This estrogenic effect appears to result from an improvement in catabolism of beta VLDL, as demonstrated by the absence of clinical signs and electrophoresis criteria during treatment. On the contrary, however, the anomalies in apoprotein E are not influenced by treatment.
D000368:Aged; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006952:Hyperlipoproteinemia Type III / Q000188:drug therapy*; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood
D008055:Lipids; D008074:Lipoproteins; D004997:Ethinyl Estradiol
Normalisation lipidique d'une dysbêtalipoprotéinémie de type III par l'éthinyl estradiol (50 microgramme/jour) chez une femme de 87 ans.