title: The in vitro uptake of 14C-praziquantel by cestodes, trematodes, and a nematode.
abstract: 14C-praziquantel was rapidly taken up by Schistosoma mansoni, Fasciola hepatica, Hymenolepis nana, and isolated strobilocerci of Taenia taeniaeformis. Schistosoma mansoni lost praziquantel rapidly to drug-free medium. Chromatography of extracts prepared after incubation of S. mansoni and H. nana yielded no indication that praziquantel was metabolized. Autoradiography revealed a uniform distribution of praziquantel throughout the tissues of S. mansoni and H. nana. Uptake was considerably slower in the nematode Heterakis spumosa and apparently via the oral route.
mesh_terms: D000818:Animals; D002250:Carbon Radioisotopes; D002589:Cestoda / Q000378:metabolism*; D005210:Fasciola hepatica / Q000378:metabolism; D006926:Hymenolepis / Q000378:metabolism; D007546:Isoquinolines / Q000378:metabolism*; D009348:Nematoda / Q000378:metabolism*; D011223:Praziquantel / Q000378:metabolism*; D012550:Schistosoma mansoni / Q000378:metabolism; D014018:Tissue Distribution; D014200:Trematoda / Q000378:metabolism*
chemical_list: D002250:Carbon Radioisotopes; D007546:Isoquinolines; D011223:Praziquantel