[Metabolism of fenofibrate and fenofibric acid in vivo and in cultures of liver epithelial cells (author's transl)].
In vitro and in vivo studies using capillary column gas chromatography alone or coupled with mass spectrometry resulted in the identification of several metabolites of fenofibrate (LF 178). Fenofibric acid (LF 153) was omnipresent, being found in rats after acute, subacute and chronic administration, in human urine during chronic treatment, and in cultures of rat and human liver cells. Other metabolites were LF 433 (LF 153 benzhydrol), which increases in rats with the duration of treatment while LF 153 decreases, and LF - phenol" found in human urine. In hepatocyte cultures, fenofibric acid was predominant, but fenofibrate itself and LF 321 (LF 178 benzhydrol) were also present in addition to the above-mentioned metabolites. LF 321, however, was only found in human liver cell cultures.
D000818:Animals; D002478:Cells, Cultured; D002849:Chromatography, Gas; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D011345:Fenofibrate / Q000031:analogs & derivatives / Q000378:metabolism*; D006801:Humans; D000960:Hypolipidemic Agents / Q000378:metabolism*; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008297:Male; D013058:Mass Spectrometry; D011422:Propionates / Q000378:metabolism*; D051381:Rats
D000960:Hypolipidemic Agents; D011422:Propionates; C006012:fenofibric acid; D011345:Fenofibrate
Métabolisme du fénofibrate et de l'acide fénofibrique in vivo et dans des cultures épithéliales hépatiques. Première étude.