[Mechanisms of action of NAD in cerebral circulatory insufficiency].
Nicotinamide adenine dinucleotide (NAD) decreases the resistance of cerebral vessels and increases the local (hydrogen clearance) and regional (133Xe clearance) cortical blood flow in intact cats. In cerebral blood flow deficiency the level of ammonia in brain tissue is appreciably increased. Favouring normalization of the deranged cerebral blood flow NAD neutralizes excess ammonia by means of glutamate dehydrogenase activity recovery in the reduction amination reaction. This indicates that NAD influences the neurochemical mechanisms of compensatory regulation of the cerebral blood flow.
D000641:Ammonia / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology; D002339:Carotid Arteries; D002415:Cats; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000188:drug therapy*; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D007269:Injections, Intra-Arterial; D007274:Injections, Intraperitoneal; D009243:NAD / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats
D009243:NAD; D000641:Ammonia; D005969:Glutamate Dehydrogenase
Mekhanizmy deĭstviia NAD pri nedostatochnosti krovosnabzheniia mozga.