title: Co-trimoxazole sensitivity testing: comparison of separate and combined disk agar diffusion techniques.
abstract: Five hundred and seven strains of bacteria isolated from the urine of patients with significant bacteriuria (more than 10(8) colony-forming units per litre) were tested for sensitivity to co-trimoxazole by the agar diffusion technique. Each organism was tested with a combined disk containing trimethoprim and sulphamethoxazole in a primary sensitivity test and, at a standardised inoculum, with both a combined disk and separate disks of trimethoprim and sulphamethoxazole. The results show that combined disk testing does not always indicate the sensitivity patterns of the organisms being tested.
mesh_terms: D000362:Agar; D001419:Bacteria / Q000187:drug effects*; D001437:Bacteriuria / Q000382:microbiology; D004338:Drug Combinations; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D013420:Sulfamethoxazole / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*
chemical_list: D004338:Drug Combinations; D000362:Agar; D014295:Trimethoprim; D013420:Sulfamethoxazole