Pathologic S-phase in the cells of eccrine sweat glands and of hair follicles in psoriasis.
The prolongation of the S-phase, characteristic of psoriatic keratinocytes, can be observed in cells of the eccrine sweat glands as well as in those of the infundibular part of hair follicles. In healthy individuals the average duration of DNA-synthesis time (ts) in the cells of the hair follicle is 6.8 h, in unaffected psoriatic skin 11.6 h, and in affected psoriatic skin 8.4 h. Ts in the proliferating cells of the eccrine sweat glands reveals no difference between normal skin and unaffected psoriatic skin, but is markedly prolonged in affected psoriatic skin.
D002453:Cell Cycle; D004247:DNA / Q000096:biosynthesis*; D004439:Eccrine Glands / Q000378:metabolism / Q000473:pathology*; D006197:Hair / Q000473:pathology*; D006801:Humans; D011565:Psoriasis / Q000378:metabolism / Q000473:pathology*; D013545:Sweat Glands / Q000473:pathology*; D013997:Time Factors
D004247:DNA