Steroid-induced ultrastructural changes in the proximal convoluted tubule cells of baboon kidneys with special reference to peroxisomes.
An electron microscopic study was performed on kidneys of immature female baboons, Papio hamadryas, that received a series of 10 consecutive weekly injections of the synthetic glucocorticoid, Triamcinolone hexacetonide (4 mg/kg body wt). In the steroid-treated kidneys the most distinctive change found is a significant increase in the number and a marked change in the form of peroxisomes (microbodies) in proximal convoluted tubule cells. These cells also develop hypertrophic mitochondria and in some instances mitochondrial hyperplasia is present to such a degree as to lead to the formation of "oxyphil-like" mitochondrion-rich cells, containing degenerating nuclei. Many proximal cells also develop large secondary lysosomes packed with fibrous contents. Our results indicate a morphological response in proximal tubule cells caused by the corticosteroid-treatment, though the responses seen may possibly be also due to the development of a secondary hyperparathyroidism.
D000818:Animals; D005260:Female; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000648:ultrastructure; D008247:Lysosomes / Q000187:drug effects; D008830:Microbodies / Q000187:drug effects / Q000648:ultrastructure; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects; D010215:Papio; D014222:Triamcinolone Acetonide / Q000494:pharmacology*
D014222:Triamcinolone Acetonide