Intraventricular carbachol mimics the phase-shifting effect of light on the circadian rhythm of wheel-running activity.
Intraventricular injections of carbachol, a cholinergic agonist, into free-running mice can cause phase dependent phase shifts, in both directions, in the circadian rhythm of wheel-running activity. These effects mimic the action of light in entraining the circadian pacemaker, and suggest that acetylcholine may play a role in photoentrainment.
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D002940:Circadian Rhythm / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects*
D002217:Carbachol; D000109:Acetylcholine