title: [Modification of stimulus threshold increase following heart pacemaker implantation by prednisolone].
abstract: In a retrospective study concerning 39 patients with pacemakers is reported on the possibility of a medicamentous influence of so-called increases of the stimulus threshold with exit block. Inflammatory tissue reactions and disturbances of electrolytes as well as microdislocations at the tip of the electrode are given as a cause of the postoperatively appearing deficiency of the stimulation. A differentiation of these causes is not possible with simple paraclinical examination methods. Generally using prednisolone we succeeded in decreasing the stimulus threshold in about half the patients within ca. 3 weeks and thus in removing the exit block. After discussion of the pathophysiological connections recommendations for the therapeutic approach are described.
mesh_terms: D000368:Aged; D005260:Female; D006327:Heart Block / Q000188:drug therapy; D006801:Humans; D008297:Male; D010138:Pacemaker, Artificial / Q000009:adverse effects; D011184:Postoperative Period; D011239:Prednisolone / Q000627:therapeutic use*; D012189:Retrospective Studies
chemical_list: D011239:Prednisolone
vernacular_title: Zur Beeinflussung des Reizschwellenanstieges nach Herzschrittmacherimplantation durch Prednisolon.