[Effect of allopurinol on adrenergically induced changes in serum lipid levels, heart rate and blood pressure in normal and ischemic rabbits (author's transl)].
In accordance with previous results obtained in healthy volunteers 1H-pyrazolo[3,4-d]pyrimidin-4-ol (allopurinol) showed an inhibiting effect on the adrenergically induced mobilization of free fatty acids in normal rabbits. The effect of allopurinol was nearly equal to that of prostaglandin E1 but less than that of pyridyl carbinol. Similarly like in patients with coronary heart disease, this effect was not found in rabbits with cardiac damage following isoprenaline pretreatment. Allopurinol at higher dosage diminished the noradrenaline-induced decrease of heart rate and increase of blood pressure.
D000493:Allopurinol / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology; D008053:Lipid Mobilization / Q000187:drug effects; D008297:Male; D009540:Nicotinyl Alcohol / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D011817:Rabbits
D005230:Fatty Acids, Nonesterified; D011458:Prostaglandins E; D000493:Allopurinol; D009540:Nicotinyl Alcohol; D007545:Isoproterenol; D009638:Norepinephrine
Wirkung von Allopurinol auf adrenerg induzierte Anderungen von Serumlipidkonzentrationen, Herzfrequenz und Blutdruck an normalen und myokardial vorgeschädigten Kaninchen.