Trimethyltin-induced hyperactivity: time course and pattern.
Adult male Long-Evans rats were intubated with either 0, 5, 6 or 7 mg/kg trimethyltin chloride. Activity was measured for 1 hr in a figure-eight maze 2 hr after dosing (day 0) and again on days 4, 8, 16 and 32 after dosing. On days 49-51, activity was measured in a figure-eight maze over a 23-hr period. There were no differences in activity on the day of dosing, but on all subsequent test days the 7 mg/kg TMT animals were hyperactive. TMT also altered the spatial pattern of activity: activity was increased in the "figure-eight" portion of the maze but not in the blind alleys. ACtivity of the 7 mg/kg TMT animals was increased during all periods in the 23-hr test. Decreases in the length of the pyramidal cell line (CA1 to CA3c of the hippocampus) confirmed neuronal cell loss in TMT-dosed rats.
D000818:Animals; D002940:Circadian Rhythm; D006624:Hippocampus / Q000187:drug effects; D006801:Humans; D006948:Hyperkinesis / Q000139:chemically induced*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014220:Trialkyltin Compounds / Q000633:toxicity*; D014298:Trimethyltin Compounds / Q000633:toxicity*
D014220:Trialkyltin Compounds; D014298:Trimethyltin Compounds