[Suppressive effect of synthetic polypeptide GT on the induction of delayed-type hypersensitivity to a complex GT + methylated bovine serum albumin (author's transl)].
Delayed-type hypersensitivity (DTH) to the random copolymers poly(Glu50Tyr50) (GT) or poly(Glu60Ala30Tyr10) (GAT) could be produced in BALB/c mice when the polymers were injected complexed to a methylated bovine serum albumin (mBSA). The pretreatment with GT or with mBSA 4 days before the immunisation with the complex GT-mBSA suppressed the induction of the DTH to both GT and mBSA moieties of the GT-mBSA complex. A similar pretreatment with GAT had no suppressor effect on the induction of DTH to GT-mBSA. Injection of cyclophosphamide 2 days before or 2 days after the pretreatment with GT eliminated the suppressor effect of GT on the induction of DTH with the complex GT-mBSA.
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000517:prevention & control*; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D008807:Mice, Inbred BALB C; D010455:Peptides / Q000276:immunology / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000276:immunology*
D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C029180:methylated bovine serum albumin; D012710:Serum Albumin, Bovine; C027606:L-glutamic acid-L-tyrosine copolymer; D003520:Cyclophosphamide
Suppression par le polypeptide synthétique poly(Glu50Tyr50) (GT) de l'induction de l'hypersensibilité retardée au complexe GT-séralbumine bovine méthylée.