A new microsurgical method for the induction of arterial thrombosis in rats.
A new microsurgical procedure for the induction of thrombosis in rat aorta is described. The method is based on the introduction into the vascular lumen of a small piece of the aortic wall, the so called "aortic flap". A long-lived, platelet-rich arterial thrombus invariably forms on the inserted aortic flap. These thrombi closely resemble human arterial thrombi in structure and subsequent development.
D000818:Animals; D001011:Aorta; D001777:Blood Coagulation; D001792:Blood Platelets / Q000503:physiopathology; D005337:Fibrin; D005347:Fibroblasts / Q000503:physiopathology; D007962:Leukocytes / Q000503:physiopathology; D008297:Male; D008866:Microsurgery; D010586:Phagocytes / Q000503:physiopathology; D051381:Rats; D013927:Thrombosis / Q000209:etiology*; D013997:Time Factors
D005337:Fibrin