Chemoprophylactic activity of flubendazole against adult Brugia pahangi transplanted into the peritoneal cavity of jirds.
Jirds were treated by the subcutaneous injection of 100 mg flubendazole per kilogram. They were infected subsequently by the implantation of adult Brugia pahangi intraperitoneally at different times. No adult worms survived in jirds treated 9 wk before infection. Thereafter, increasing numbers of adult worms survived so tht by 21 wk there were almost as many worms in the treated jirds as in untreated controls.
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D002009:Brugia; D005260:Female; D005368:Filariasis / Q000469:parasitology / Q000517:prevention & control*; D005369:Filaricides / Q000008:administration & dosage / Q000627:therapeutic use*; D005849:Gerbillinae; D008297:Male; D008463:Mebendazole / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D010529:Peritoneal Cavity / Q000469:parasitology
D000871:Anthelmintics; D001562:Benzimidazoles; D005369:Filaricides; D008463:Mebendazole; C018945:flubendazole