Side effects of dexedrine in hyperactive children: operationalization and quantification in a short-term trial.
1. Four common side effects of dexedrine use (viz., anorexia, insomnia, stomach pains, and weight loss) were operationalized and quantified for use by parents in monitoring these effects over a 6 week clinical trial. 2. A weighted summary score, reflecting the frequency and intensity of each side effect, was used to determine the magnitude of each effect during treatment. 3. Four hyperactive children taking 2,5 mg twice daily, and six other hyperactive children taking either 5 or 10 mg twice daily, served as subjects. 4. Results indicated that the average weighted summary scores for all effects did not exceed minimal levels as defined in this study, regardless of dosage. 5. The implications, importance, and usefulness of this side effects scale in treating hyperactive children were discussed.
D000855:Anorexia / Q000139:chemically induced; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000523:psychology; D001835:Body Weight / Q000187:drug effects; D002648:Child; D003913:Dextroamphetamine / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000009:adverse effects / Q000627:therapeutic use; D010146:Pain / Q000139:chemically induced; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced; D013272:Stomach Diseases / Q000139:chemically induced
D008774:Methylphenidate; D003913:Dextroamphetamine