Enovid-induced exacerbation of high blood pressure in stroke-prone rats (SHR).
Male and female, normotensive Wistar:Kyoto rats, spontaneously hypertensive rats (SHR), and Stroke-prone SHR (SHR/SP) with severe hypertension were treated with a contraceptive drug (Enovid) from the time of weaning until they became 180 days old. Although the Envoid-treated SHR and SHR/SP had exacerbations of their high blood pressure, none of the animals developed renal or cerebral damage. Chronic treatment with Enovid caused testicular and ovarian atrophy and a significant increase in circulating corticosterone. It is suggested that the potentially deleterious effects, e.g., stroke, hypertension, hyperglycemia, hyperlipidemia, etc., of chronic treatment with contraceptive drugs is largely determined by pre-existing genetically endowed proneness or resistance.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002561:Cerebrovascular Disorders / Q000150:complications*; D003277:Contraceptives, Oral, Combined; D003345:Corticosterone / Q000097:blood; D005260:Female; D006321:Heart / Q000033:anatomy & histology; D006973:Hypertension / Q000150:complications / Q000209:etiology*; D007668:Kidney / Q000033:anatomy & histology; D008297:Male; D008656:Mestranol / Q000494:pharmacology*; D009203:Myocardial Infarction / Q000150:complications; D009641:Norethynodrel / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000473:pathology; D051381:Rats; D013737:Testis / Q000473:pathology
D003277:Contraceptives, Oral, Combined; C008124:Infecundin; D009641:Norethynodrel; D008656:Mestranol; D003345:Corticosterone