Influence of sex and age on the biological half-life of cadmium in mice.
The influence of age on the whole-body biological half-life of 109Cd was studied in male mice following ip injection. The influence of sex on whole-body and organ retention was ascertained after sc injection. The whole-body biological half-life of 109Cd of the older mice was more than twice that of the younger mice, and that of the female mice was longer than that of the male. In kidneys and salivary glands the biological half-lives of 109Cd of females were also longer than those of males. These differences demonstrate a biological difference between males and females with respect to whole-body half-life of 109Cd. The effects of age and sex on the biological half-life of Cd in mice are assessed quantitatively.
D000375:Aging; D000818:Animals; D002104:Cadmium / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008954:Models, Biological; D012737:Sex Factors
D002104:Cadmium