[Effect of cholinergic factors on the state of erythrocyte membrane proteins of animals].
Experiments were carried out on 10 dogs to study the effect of high cholinergic activity of blood on the redox processes in membrane proteins of red blood cells. An increase in blood cholinergic activity was induced by parenteral injection of acetylcholine (0.9 mg/kg) and proserin (0.008 mg/kg) twice daily over 2 to 7 months. Long-term ĩncrease of blood cholinergic activity caused an elevation of solubilization of membrane proteins and redistribution of individual polypeptide from integral protein fractions into peripheral ones. The peripheral proteins manifested a pronounced increase in the number of sulfhydryl and reduction in disulfide groups. These data correlated with changes in the level of pyridine nucleotides in intact cells.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D009243:NAD / Q000032:analysis; D009249:NADP / Q000032:analysis; D010084:Oxidation-Reduction; D010455:Peptides / Q000032:analysis; D010830:Physostigmine / Q000494:pharmacology*
D008565:Membrane Proteins; D010455:Peptides; D009243:NAD; D009249:NADP; D010830:Physostigmine; D000109:Acetylcholine
Vliianie kholinergicheskikh faktorov na sostoianie membrannykh belkov éritrotsitov zhivotnykh.