Effect of testosterone on neuronal refractory periods, sexual behaviour and luteinizing hormone: a comparison of time-courses.
Measurements of the refractory period of stria terminalis neurones that are sensitive to testosterone propionate, of sexual behaviour and of plasma levels of LH were taken in castrated rats at various times after initiation of treatment with testosterone propionate. Levels of LH dropped within 24 h, before there was any change in neuronal refractory periods. The period of latency to mounting, however, was reduced to its shortest only after 7-8 days and ejaculations first occurred at the same time; these sexual responses correlated in time with reduction of the neuronal refractory period to its lowest level.
D000679:Amygdala / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002369:Castration; D004594:Electrophysiology; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D009431:Neural Conduction / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D051381:Rats; D012032:Refractory Period, Electrophysiological / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013739:Testosterone / Q000494:pharmacology*; D013997:Time Factors
D013739:Testosterone; D007986:Luteinizing Hormone