Acetylcholinesterase and cholinesterase activities in the mouse cerebellum following misonidazole treatment.
The acetylcholinesterase and cholinesterase activities in the mouse cerebellum were unchanged following misonidazole treatment. Inhibition of acetylcholinesterase activity only occurred at concentrations of misonidazole which were in excess of those obtained clinically. These findings indicate that the clinical neurotoxicity of the drug cannot be attributed to an effect on cholinesterases.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D002531:Cerebellum / Q000201:enzymology*; D002802:Cholinesterases / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008920:Misonidazole / Q000494:pharmacology*; D009593:Nitroimidazoles / Q000494:pharmacology*
D009593:Nitroimidazoles; D008920:Misonidazole; D000110:Acetylcholinesterase; D002802:Cholinesterases