The effect of certain variables on the tumor and tissue distribution of tracers. III. Salicylates and vasoactive drugs.
Attempts were made to increase the viable tumor concentration of 54Mn and 67Ga in a rat hepatoma model by administering rat angiotensin, tolazoline, and salicylates. Salicylates increased the tumor concentrations of 54Mn and improved 65Mn viable tumor/background ratios. 67Ga was not affected by the salicylates. The salicylate effect appeared to be mediated by intracellular mechanisms rather than alterations in plasma protein binding. Rat angiotensin slightly increased the concentrations of 67Ga in the tumors but not enough to suggest that it would be useful clinically. Tolazoline did not increase tumor uptake of the tracers.
D000818:Animals; D005708:Gallium / Q000378:metabolism; D005710:Gallium Radioisotopes; D008114:Liver Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000378:metabolism; D008345:Manganese / Q000378:metabolism; D009368:Neoplasm Transplantation; D011868:Radioisotopes; D011877:Radionuclide Imaging; D051381:Rats; D012459:Salicylates / Q000494:pharmacology*; D014018:Tissue Distribution; D014662:Vasoconstrictor Agents / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
D005710:Gallium Radioisotopes; D011868:Radioisotopes; D012459:Salicylates; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D008345:Manganese; D005708:Gallium