Angina-like pain: an unexpected side-effect following the simultaneous administration of angiotensin II and prostaglandin E2 in normal adults.
Two fit young, non-pregnant adults both experienced marked retrosternal chest pain and chest tightness when receiving 8 ng kg-1 min-1 AII simultaneously with 5 microgram min-1 PGE2. This dose of AII is well within that given experimentally by various workers, and was without such effect when initially given in the absence of PGE2 infusion. The combination dangerous one.
D000328:Adult; D000787:Angina Pectoris / Q000139:chemically induced*; D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004357:Drug Synergism; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology*
D011458:Prostaglandins E; D000804:Angiotensin II