Progressive systemic sclerosis and nephrotic syndrome. An unusual association resulting in postpartum acute renal failure.
A 27-year-old, full-term pregnant woman with progressive systemic sclerosis (PSS) came to the hospital with marked proteinuria and edema. Two days later, she gave birth to a normal baby. After delivery and during the next 48 hours, renal failure developed. A renal biopsy specimen disclosed findings characteristic of PSS, and immunofluorescence studies displayed nonspecific deposits of fibrinogen and complement. The patient's general condition deteriorated, with development of pericarditis and pulmonary failure; after several peritoneal dialysis treatments, a peritoneal infection developed, and the patient died of Gram-negative sepsis. The association of PSS and nephrotic syndrome is unusual.
D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology; D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000473:pathology; D009404:Nephrotic Syndrome / Q000150:complications* / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications; D011644:Puerperal Disorders / Q000209:etiology*; D012595:Scleroderma, Systemic / Q000150:complications* / Q000473:pathology