[Lightmicroscopic studies of plasma permeability at the blood brain barrier in experimental neurogenic interoreceptive hypertension of the rat (author's transl)].
The plasma permeation with its consequences on the nervous system was studied by means of an experimental neurogenic interoreceptive hypertension model. Out of 30 experimental animals (5 controls) showed 7 cerebral extravasations with blood pressure value ranging from 160--170 mm Hg within 4 and 8 weeks, respectively, as proved by Evans Blue injection or subsequent staining of the plasma with Luxol Fast Blue. The permeation sites were found hood-shaped on arterioles with a diameter of 15--30 micrometers, in multifocal arrangement with a certain preference for the frontal cerebral structures. The cerebral damages proved to be microinfarctions, mostly incompletely anemic necroses and forms of neuronal degeneration. Topical coincidence with extravasations is not always present. Further causal factors of cerebral lesions are discussed.
D000818:Animals; D001812:Blood-Brain Barrier; D002199:Capillary Permeability; D005119:Extravasation of Diagnostic and Therapeutic Materials; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D009410:Nerve Degeneration; D051381:Rats; D013562:Sympathectomy
Lichtmikroskopische Studien der Plasmapermeabilität an der Blut-Hirnschranke bei der experimentellen neurogen interorezeptiven Hypertonie der Ratte.