Hyperlipoproteinaemia and reduced fibrinolytic activity in healthy coronary high-risk men.
One hundred and four consecutive men from the non-symptomatic hyperlipoproteinaemic group of the Oslo Study were examined with regard to their fibrinolytic response to venous occlusion of the arm. Sixty-eight per cent showed reduced fibrinolytic activity as compared to 24% of 21 age-matched healthy coronary low-risk men. In the hyperlipoproteinaemic group, 55 individuals had been on a moderate lipid-lowering diet for about 3 years, whereas the other 49 had not (controls). The diet group showed a market tendency towards normalization of their lipoprotein patterns, but this was not significantly associated with normalization of the fibrinolytic activity. Out of 20 men with type IV hyperlipoproteinaemia, 95% showed reduced fibrinolytic activity. The association between hypertriglyceridaemia (type IV hyperlipoproteinaemia) and reduced fibrinolytic activity might possibly be explained by a reduced lipoprotein lipase activity in these individuals.
D000328:Adult; D003327:Coronary Disease / Q000517:prevention & control; D005342:Fibrinolysis; D005500:Follow-Up Studies; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood* / Q000178:diet therapy; D006953:Hyperlipoproteinemia Type IV / Q000097:blood* / Q000178:diet therapy; D008297:Male; D011897:Random Allocation; D012306:Risk; D012907:Smoking