Effect of dihydrotestosterone on follicular development, ovulation and reproductive capacity of mice.
A single injection of a 5 alpha-dihydrotestosterone (DHT) was administered to cyclic female mice on the day of metoestrus. DHT (1 mg) prolonged the dioestrous stage of the cycle by 24 h and there were 50% fewer large (normal) follicles than in oil-injected controls. Degenerating ova were observed in the oviduct of 70% of the DHT-treated mice and there was a significant reduction in the numbers of females becoming pregnant and bearing normal fetuses.
D000818:Animals; D004031:Diestrus / Q000187:drug effects; D013196:Dihydrotestosterone / Q000494:pharmacology*; D005260:Female; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D006080:Ovarian Follicle / Q000187:drug effects*; D010053:Ovary / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects*; D011247:Pregnancy
D013196:Dihydrotestosterone