Radiosensitivity of Hodgkin's disease lymphocytes.
Blood lymphocyte subpopulations from 10 untreated patients with Hodgkin's disease and 10 healthy controls were examined with respect to their radiosensitivity in vitro. T-cells (E-rosette forming) were more sensitive in 7 out of the 10 patients whereas these cells appeared to be relatively radioresistant in all control persons. However, a subpopulation of T-cells forming "active" E-rosettes, was relatively resistant in 9 of the patients and all of the controls. Non-T-cells (EAC-rosette forming) were equally sensitive in patients and in controls.
D000328:Adult; D000368:Aged; D005260:Female; D006689:Hodgkin Disease / Q000503:physiopathology*; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000145:classification / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D011836:Radiation Tolerance; D012397:Rosette Formation