Increased concentration and accelerated synaptosomal uptake of noradrenaline in the central nervous tissues of neonatally hemispherectomized adult rats.
Neonatally hemispherectomized adult rat brain was analyzed. The content of noradrenaline (NA) had increased significantly in the brain stem (+ 116%) and the cerebellum (+ 100%) by the 3rd month after operation. The Km for the high affinity uptake of NA by the brain stem synaptosomes stayed unchanged but Vmax was almost doubled by the operation. Fluorescence histochemical findings also suggest sprouting of noradrenergic axons in specific brain regions.
D000818:Animals; D000831:Animals, Newborn; D001369:Axons / Q000502:physiology; D001921:Brain / Q000378:metabolism*; D001933:Brain Stem / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism; D002540:Cerebral Cortex / Q000502:physiology*; D003714:Denervation; D004292:Dominance, Cerebral / Q000502:physiology; D009416:Nerve Regeneration; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism*
D009638:Norepinephrine