title: [Phasic action of inhibitors of transmembrane amino acid transport].
abstract: The analysis of the effect of inhibitors blocking the systems of energy reproduction, on active transport, in particular of aminoacids, in enterocytes of rats showed that inhibitors had 3 phases of the effect depending on their concentration or term of their exposure: inhibition; paradoxical phase when inhibitors stimulate the transport; and the inhibition again. At the first two phases the effect of inhibitors is reversible and can be abolished with glucose. The third phase is irreversible. The data suggest that the cell is capable to control the level of substance transport through the membranes by energy-dependent regulatory mechanisms.
mesh_terms: D000596:Amino Acids / Q000378:metabolism* / Q000528:radiation effects; D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects / Q000528:radiation effects; D003529:Cymarine / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006019:Glycolysis; D007408:Intestinal Absorption / Q000187:drug effects* / Q000528:radiation effects; D007461:Iodoacetates / Q000494:pharmacology; D008297:Male; D051381:Rats; D012966:Sodium Cyanide / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D007461:Iodoacetates; D005947:Glucose; D012966:Sodium Cyanide; D003529:Cymarine
vernacular_title: Faznost' deĭstviia ingibitorov transmembrannogo perenosa aminokislot.