title: A rapid and specific method for measuring chloramphenicol degradation in aqueous solution following autoclaving.
abstract: An HPLC method is reported for the measurement of chloramphenicol and its degradation product following autoclaving. The procedure, using a reversed-phase column and potassium phosphate solution as the solvent, is shown to be suitable for monitoring chloramphenicol degradation in intrathecal injections after sterilisation.
mesh_terms: D002701:Chloramphenicol / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D004356:Drug Storage; D013242:Sterilization; D013696:Temperature
chemical_list: D002701:Chloramphenicol