Dibutylchloromethyltin chloride, a potent inhibitor of electron transport in plant mitochondria.
Dibutylchloromethyl tin chloride (DBCT) inhibits coupled and uncoupled respiration of mitochondria from potato tubers, cauliflower florets and etiolated mung bean hypocotyls with succinate and L-malate but not with external NADH or TMPD/ascorbate as substrates. Using potato and cauliflower mitochondria. DBCT at 200 pmole/mg of protein gives complete inhibition  only in KCl-based media and at pH 6.8. DBCT has no effect on the internal pH of mung bean mitochondria, but does cause a decrease in the membrane potential. Electron transport through the alternative oxidase is not inhibited, neither is the ATP-synthase system. DBCT appears to interact with the functionally-distinct pool of ubiquinone associated with the oxidation of succinate and L-malate.
D004579:Electron Transport / Q000187:drug effects*; D008928:Mitochondria / Q000187:drug effects*; D009947:Organotin Compounds / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D010944:Plants / Q000187:drug effects* / Q000378:metabolism; D014220:Trialkyltin Compounds
D009947:Organotin Compounds; D014220:Trialkyltin Compounds; C015129:dibutylchloro(chloromethyl)tin