Nephrotic syndrome, linear glomerular IgG deposits, and minimal glomerular changes. Report of a case.
A young adult patient had an unusual acute idiopathic nephrotic syndrome. This nephrotic syndrome was remarkable for (1) association with acute renal failure and hypertension, (2) finding of minimal glomerular changes with a linear fixation of the anti-human IgG conjugate along the glomerular capillary wall without demonstrable antiglomerular basement membrane antibodies, and (3) complete recovery, including disappearance of the linear staining, after treatment with prednisone, cyclophosphamide, and plasmapheresis.
D000208:Acute Disease; D058186:Acute Kidney Injury / Q000150:complications; D000328:Adult; D003176:Complement C3 / Q000032:analysis; D006801:Humans; D006973:Hypertension / Q000150:complications; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology*; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications*
D003176:Complement C3; D007074:Immunoglobulin G; D007075:Immunoglobulin M