title: [Prevention of wound infection in open skull and brain injuries].
abstract: Measures aimed at the prevention of complications gain foremost importance when timely surgical treatment of a penetrating craniocerebral wound cannot be conducted. Experimental research and clinical experience have shown that the administration of 50 000--100 000 U of an antibiotic (kanamycin, monomycin, hectamycin, chloramphenicol) into the wound soon after an open penetrating injury had been inflicted to the skull and brain protects the wound from microbial contamination. This provides the possibility for postponing the plastic operation of the defect in the dura mater.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001419:Bacteria / Q000302:isolation & purification; D001424:Bacterial Infections / Q000517:prevention & control; D001930:Brain Injuries / Q000188:drug therapy* / Q000382:microbiology; D004285:Dogs; D007612:Kanamycin / Q000008:administration & dosage; D012887:Skull Fractures / Q000188:drug therapy* / Q000382:microbiology; D014946:Wound Infection / Q000517:prevention & control*; D014950:Wounds, Penetrating / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D007612:Kanamycin
vernacular_title: O profilaktike infitsirovaniia ran pri otkrytykh povrezhdeniiakh cherepa i golovnogo mozga.