Vascular responsiveness and body fluid status in patients on chronic hemodialysis.
The vascular responsiveness and the body fluid distribution were studied in 5 hypotensive and 11 normotensive patients on long-term hemodialysis. A diminished vascular responsiveness to intravenously infused norepinephrine or angiotensin II was found in uremic patients, especially in the hypotensive group. A slightly larger, but non-significant circulating blood volume (CBV) and a less extracellular fluid volume (ECF) was found in the hypotensive group as compared with those of the normotensive group. These results suggest that with autonomic nervous dysfunction, such a diminution of vascular responsiveness may be an another factor responsible for the development of hypotension.
D000328:Adult; D000804:Angiotensin II / Q000627:therapeutic use; D001775:Blood Circulation; D001794:Blood Pressure / Q000187:drug effects; D001826:Body Fluids; D001835:Body Weight; D002908:Chronic Disease; D006801:Humans; D007022:Hypotension / Q000188:drug therapy; D008875:Middle Aged; D009638:Norepinephrine / Q000627:therapeutic use; D006435:Renal Dialysis
D000804:Angiotensin II; D009638:Norepinephrine