Phosphoenolpyruvate synthesis by fetal guinea-pig liver mitochondria.
Liver mitochondria isolated from fetal and newborn guinea pigs synthesized phosphoenolpyruvate at 4-6 nmol/min per mg protein with 2 mM malate, succinate, and alpha-ketoglutarate as substrates. These rates were 90-110% of that by adult liver mitochondria and were not substantially altered in the second half of gestation or within 24 h after birth. Both palmitoyl- and octanoylcarnitine were inhibitory to phosphoenolpyruvate synthesis in adult and fetal preparations, but free octanoate was inhibitory only in adult liver mitochondria.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002210:Caprylates / Q000494:pharmacology; D002331:Carnitine / Q000031:analogs & derivatives / Q000494:pharmacology; D006168:Guinea Pigs; D007656:Ketoglutaric Acids / Q000378:metabolism; D008293:Malates / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010172:Palmitoylcarnitine / Q000494:pharmacology; D010728:Phosphoenolpyruvate / Q000096:biosynthesis*; D013386:Succinates / Q000378:metabolism
D002210:Caprylates; D007656:Ketoglutaric Acids; D008293:Malates; D013386:Succinates; D010172:Palmitoylcarnitine; D010728:Phosphoenolpyruvate; C008698:octanoylcarnitine; D002331:Carnitine