The action of bromocriptine on human detrusor muscle.
The pharmacological effects of bromocriptine on human detrusor muscle were investigated by an in vitro isometric method. Both a direct stimulating effect and an anticholinergic effect were demonstrated. These effects, together with an alpha-adrenergic blocking effect reported in a previous paper, are correlated with the published clinical effects of bromocriptine in patients with primary and secondary unstable detrusors.
D001626:Bethanechol Compounds / Q000037:antagonists & inhibitors / Q000494:pharmacology; D001971:Bromocriptine / Q000494:pharmacology*; D006801:Humans; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D013268:Stimulation, Chemical; D001743:Urinary Bladder / Q000187:drug effects*
D001626:Bethanechol Compounds; D001971:Bromocriptine; D009638:Norepinephrine