Shortening of life span caused by administration of 5-bromodeoxyuridine to neonatal rats.
Newborn rats and adult animals in which liver cell replication had been induced by partial hepatectomy were injected with 5-bromodeoxyuridine (BUdR), and were kept without further treatment for the remainder of their life span. No evidence for carcinogenicity of BUdR was obtained, but a dose-dependent shortening of the life span was observed after administration to neonatal animals.
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001973:Bromodeoxyuridine / Q000633:toxicity*; D002273:Carcinogens; D004305:Dose-Response Relationship, Drug; D005260:Female; D008017:Life Expectancy; D008115:Liver Regeneration / Q000187:drug effects; D051381:Rats
D002273:Carcinogens; D001973:Bromodeoxyuridine