[The effect of glucocorticoid treatment during pregnancy on adrenal function in newborn rats (author's transl)].
The authors examined the effect of prednisolone-salium succinate administered on the 17th or 18th day of pregnancy on the adrenal function of newborn rats. They found that in doses of 1.0 or 2.0 mg/kg it does not affect physiological development or, respectively, the extent of the circadian rhythm or the stress response. However, the adrenal function of newborn animals was significantly inhibited by 30.0 mg/kg as regards its adaptability to extra-uterine life. The authors point out the importance of investigations to determine the adrenal function of newborns following steroid therapy to prevent RDS.
D000311:Adrenal Glands / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D002940:Circadian Rhythm / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects; D005938:Glucocorticoids / Q000494:pharmacology*; D011239:Prednisolone / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D005938:Glucocorticoids; D011239:Prednisolone
Die Wirkung der während der Gravidität durchgeführten Glucokortikoidbehandlung auf die Nebennierenfunktion der neugeborenen Ratten.