Ultrastructural "fingerprint" in cryoprecipitate and glomerular deposits: a case report of systemic lupus erythematosus.
A 20 year old woman had lupus nephritis and cryoglobulinemia. The cryoglobulins isolated from the serum and a renal biopsy specimen were studied by means of immunofluorescence, immunochemistry, and electron microscopy. Ultrastructural "fingerprint" structures were observed both in the cryoprecipitate and in the glomerular deposits, as were IgG, IgM, and IgA. These observations furnish morphologic evidence for the glomerular deposition of cryoglobulins in lupus nephritis.
D000328:Adult; D000936:Antigen-Antibody Complex; D011232:Chemical Precipitation; D003450:Cryoglobulins / Q000032:analysis*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology* / Q000648:ultrastructure; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000473:pathology*; D009393:Nephritis / Q000276:immunology / Q000473:pathology
D000936:Antigen-Antibody Complex; D003450:Cryoglobulins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M