title: [Endocrinologic findings in Crohn's disease].
abstract: In 45 patients with radiologically and endoscopically/histologically proven Crohn's disease the partial functions of the anterior pituitary gland were measured prior to steroid therapy. No deficiencies were observed with respect to cortico-, thyro-, gonado-, and somatotropic functions. In 25 out of 40 patients (63%) the typical diurnal rhythm of cortisol secretion was absent when assessed by a distinctly elevated 6 p.m. cortisol serum level. In about one fourth of 22 patients T3-RIA was reduced, indicating deficiency of conversion from T4 to T3. Six (43%) out of 14 males showed reduced basal testosterone levels at 8 a.m. and 6 p.m. which, in 4 out of 14 cases, did not increase sufficiently in response to HCG. The basal LH-level was elevated in 9 (50%) of 18 males. The lack of diurnal rhythm of cortisol secretion and primary insufficiency of Leydig's cells did not correlate with the activity of the disease.
mesh_terms: D000293:Adolescent; D000328:Adult; D001835:Body Weight; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D003424:Crohn Disease / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006130:Growth Disorders / Q000209:etiology; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010903:Pituitary Gland, Anterior / Q000503:physiopathology*; D012741:Sexual Maturation; D013739:Testosterone / Q000378:metabolism; D014284:Triiodothyronine / Q000032:analysis
chemical_list: D006063:Chorionic Gonadotropin; D014284:Triiodothyronine; D013739:Testosterone; D006854:Hydrocortisone
vernacular_title: Endokrinologische Befunde bei Morbus Crohn.