Effects of long-term ethanol consumption on rat peritoneal macrophages.
Rats were fed an all liquid diet for 7-8 weeks. One group received 35% of the calories as ethanol while the other group was pair-fed carbohydrates. Peritoneal macrophages prepared from ethanol treated rats had lower phagocytosis via the Fe-receptor and reduced viability in the presence of endotoxin, but their lysosomal enzyme activities measured (beta-glucuronidase, cathepsin D, acid phosphatase and acid DNase) were not different from controls.
D000135:Acid Phosphatase / Q000378:metabolism; D000437:Alcoholism / Q000276:immunology*; D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D004731:Endotoxins / Q000494:pharmacology; D006801:Humans; D008247:Lysosomes / Q000201:enzymology; D008264:Macrophages / Q000187:drug effects*; D008297:Male; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012756:Sheep / Q000276:immunology
D004731:Endotoxins; D000135:Acid Phosphatase