Hepatic vitamin A status of rats during feeding of the hepatocarcinogen 2-aminoanthraquinone.
Dietary administration of the dyestuff intermediate 2-aminoanthraquinone (AAQ) at a 2% level for periods of 2, 4, 8 or 12 weeks decreased the total liver vitamin A significantly (P less than 0.001) at all time periods in both male and female rats, compared to controls and pair-fed controls, respectively. A decrease in the body weights of AAQ-fed rats was much more pronounced in the females than male rats.
D000588:Amines / Q000633:toxicity; D000818:Animals; D000880:Anthraquinones / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D008099:Liver / Q000032:analysis* / Q000187:drug effects; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D051381:Rats; D014801:Vitamin A / Q000032:analysis*
D000588:Amines; D000880:Anthraquinones; D002273:Carcinogens; D014801:Vitamin A; C022970:2-aminoanthraquinone