Development of tolerance to dopaminergic stimulating effect of theophylline in mice with unilateral striatal 6-hydroxydopamine lesions.
Theophylline 25 mg/kg i.p. produced long-lasting contralateral rotation in mice with unilateral striatal 6-hydroxydopamine lesions, while repeated administration of theophylline caused a prominent reduction in the rotation. When mice received theophylline in combination with L-dopa, no reduction in the response was observed. Determination of forebrain theophylline showed no significant metabolic changes. These results suggest that a functional tolerance develops to the stimulating effect of theophylline on the nigrostriatal dopaminergic system.
D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D003342:Corpus Striatum / Q000502:physiology*; D004361:Drug Tolerance; D006801:Humans; D006892:Hydroxydopamines / Q000494:pharmacology*; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D051379:Mice; D011954:Receptors, Dopamine / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects; D013806:Theophylline / Q000494:pharmacology*
D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D002110:Caffeine; D007980:Levodopa; D013806:Theophylline