Some studies on the effects of ambilhar on mobilisation and excretion of lead.
The effects of administration of ambilhar to guinea pigs intoxicated with lead for one and three weeks were investigated. The results showed that administration of ambilhar to guinea pigs dosed with lead acetate resulted in a significant decrease in the liver content of lead with a concomitant increase in urinary and faecal lead excretion. The rate of lead elimination from the body was found to be dose dependent. The ultra violet studies of ambilhar and its lead soluble complex in vitro supported the possibility that the stimulation of lead excretion results from the formation of lead-ambilhar complex.
D000818:Animals; D005243:Feces / Q000378:metabolism; D006168:Guinea Pigs; D007854:Lead / Q000378:metabolism*; D007855:Lead Poisoning / Q000188:drug therapy; D008099:Liver / Q000378:metabolism; D008297:Male; D009560:Niridazole / Q000494:pharmacology*; D012556:Schistosomicides / Q000494:pharmacology*
D012556:Schistosomicides; D007854:Lead; D009560:Niridazole