[Synthesis and in vitro antibacterial activity of N-methylnitrone and nitrovinyl derivatives of some N-substituted 2-chloroindol-3-carboxaldehydes].
N-methylnitrones and nitrovinyl derivatives from 1-substituted-2-chloroindol-3-carboxaldehydes were synthesized and evaluated for their in vitro antibacterial activity. Some nitrovinyl derivatives displayed good in vitro activity against Gram-positive bacteria; the compound (II e), 1-(o-chlorobenzyl)-2-chloro-3-(2-nitroethenyl)indole, was more active than nitrofurantoin against Staphylococcus aureus and Streptococcus pyogenes. Some structure-activity relationships are discussed.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D009589:Nitrogen Oxides / Q000138:chemical synthesis / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D007211:Indoles; D009574:Nitro Compounds; D009589:Nitrogen Oxides
Sintesi ed attività antibatterica in vitro di N-metilnitroni e nitrovinili derivati da alcune 2-cloroindol-3-carbossialdeidi N-sostituite.