Gas-liquid chromatographic determination of galactitol in amniotic fluid for possible use in prenatal diagnosis of galactosaemia.
A gas liquid chromatographic method for the estimation of galactitol in amniotic fluid from pregnancies at risk for galactosaemia is described. The method is based on the almost complete removal of glucose from the amniotic fluid by ion exchange, and the subsequent chromatography of galactitol as its hexaacetate.
D000653:Amniotic Fluid / Q000032:analysis*; D002849:Chromatography, Gas / Q000379:methods; D019411:Clinical Laboratory Techniques; D005260:Female; D004376:Galactitol / Q000032:analysis*; D005693:Galactosemias / Q000175:diagnosis*; D006580:Genetic Carrier Screening; D006720:Homozygote; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013402:Sugar Alcohols / Q000032:analysis*
D013402:Sugar Alcohols; D004376:Galactitol