Pinocytic uptake of divinyl ether-maleic anhydride (pyran copolymer) and its failure to stimulate pinocytosis.
The effect of DIVEMA (pyran copolymer) and three DIVEMA derivatives on the pinocytic uptake of 125I-labeled PVP and colloidal 198Au by the rat visceral yolk sac and by rat peritoneal macrophages was studied in vitro. Contrary to expectations from some earlier data, there was no enhancement of pinocytosis and in some cases inhibition was seen. [14C]DIVEMA and 125I-labelled DIVEMA were accumulated rapidly by rat peritoneal macrophages, the results indicating that this is by an adsorptive pinocytic mechanism.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D003102:Colloids; D006050:Gold Radioisotopes; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D010873:Pinocytosis / Q000187:drug effects*; D011108:Polymers / Q000494:pharmacology*; D011205:Povidone / Q000378:metabolism; D011713:Pyran Copolymer / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D015017:Yolk Sac
D003102:Colloids; D006050:Gold Radioisotopes; D011108:Polymers; D011713:Pyran Copolymer; D011205:Povidone