A rapid gas-chromatographic method for the quantitative determination of clomethiazole in human serum.
A rapid method without elaborate instrumentation for the determination of clomethiazole serum concentrations is described. This method is suitable for a routine clinical laboratory, and the results, from 37 patients investigated by this method which are presented, are comparable to results described by other authors. A relationship between dose ingested and serum concentration can be established. The determination of clomethiazole serum concentrations is useful as an adjunct to overall clinical assessment, and helpful in establishing a suitable dosage regimen of clomethiazole for the individual patient; it can also be used to verify suspected clomethiazole abuse or overdose.
D000328:Adult; D000430:Alcohol Withdrawal Delirium / Q000188:drug therapy; D002719:Chlormethiazole / Q000097:blood*; D002849:Chromatography, Gas / Q000379:methods; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male
D002719:Chlormethiazole