title: Urinary excretion of an uracilic metabolite from caffeine by rat, monkey and man.
abstract: Caffeine (C) metabolism has been studied in rat, monkey (Macaca cynomolgus) and man after oral administration of the compound. Eleven metabolites were quantified in urine; particular attention has been drawn to 4-amino [5-formyl methylamino]1,3-dimethyl uracil (ADMU) because of its structural analogies with 5-fluorouracil. The rat has been found to produce a much larger fraction of ADMU (about 30%) in respect to monkey an man (1-2%). The potential toxicological implications of this findings are discussed.
mesh_terms: D000328:Adult; D000818:Animals; D001711:Biotransformation; D002110:Caffeine / Q000378:metabolism* / Q000652:urine; D006801:Humans; D008252:Macaca fascicularis; D008297:Male; D051381:Rats; D013045:Species Specificity; D013805:Theobromine / Q000652:urine; D013806:Theophylline / Q000652:urine; D014498:Uracil / Q000031:analogs & derivatives* / Q000652:urine; D014527:Uric Acid / Q000031:analogs & derivatives / Q000652:urine; D014970:Xanthines / Q000652:urine
chemical_list: D014970:Xanthines; D014527:Uric Acid; C008514:methylxanthine; C029567:6-amino-5-(formyl-N-methylamino)-1,3-dimethyluracil; D002110:Caffeine; D014498:Uracil; D013806:Theophylline; D013805:Theobromine; C021183:1,7-dimethylxanthine