[Accidental overdose of alfatesine in a child with multiple malformations].
An overdosage of alfathesin was accidentally administered to a 4 kg infant with multiple congenital anomalies during an operation for craniosynostosis. The overdose was a consequence of a mistake in adjusting the rate of administration of a constant flow infusion pump. The total dosage corresponded to eight times the necessary dose administered over a period of 30 minutes. The only notable effect was a delayed awakening, which necessitated assisted ventilation. The high therapeutic index of alfathesin is responsible for the absence of serious consequences.
D000530:Alfaxalone Alfadolone Mixture / Q000009:adverse effects*; D000768:Anesthesia, General; D001921:Brain / Q000002:abnormalities; D002902:Chromosomes, Human, 16-18; D002903:Chromosomes, Human, 19-20; D003394:Craniofacial Dysostosis / Q000601:surgery*; D004305:Dose-Response Relationship, Drug; D005325:Fetal Organ Maturity; D006801:Humans; D007223:Infant; D007670:Kidney Calices / Q000002:abnormalities; D012121:Respiration, Artificial; D014178:Translocation, Genetic
D000530:Alfaxalone Alfadolone Mixture
Surdosage accidentel en alfatesine chez un enfant polymalforme.