title: Serum and lung tissue levels of fosfomycin in humans.
abstract: Fosfomycin levels were determined in the serum and the lung tissue removed during 26 pulmonary operations following intramuscular or intravenous administration of 2 g fosfomycin. In the serum the level was about 32 micrograms/ml 1--2 h subsequent to the administration. At the same time, the removed lung tissue showed 12--16 micrograms/g concentration in the apparently intact parts, amounting to 32--52% of the serum level, whereas in the tumorous lung tissue roughly half of this concentration was present. The fosfomycin levels found in the lung tissue are effective only against a group of bacteria causing respiratory inflammation.
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D005260:Female; D005578:Fosfomycin / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D000900:Anti-Bacterial Agents; D005578:Fosfomycin