[Activation of cyclophosphane when stored as a solution].
There was found an effect of nonenzymic activation of cyclophasphane when keeping its solution during 24 hours at 37 degrees C. The products, formed as a result of its hydrolysis, induce chromosome rearrangement in the L-fibroblast culture in vitro while cyclophosphane dissolved immediately before the injection into the cell culture does not show a marked cytogenetic effect.
D000818:Animals; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000494:pharmacology*; D004356:Drug Storage; D066298:In Vitro Techniques; D007739:L Cells / Q000187:drug effects; D051379:Mice; D012996:Solutions; D013696:Temperature; D013997:Time Factors
D012996:Solutions; D003520:Cyclophosphamide
Aktivatisiia tsiklofosfana pri khranenii ego rastvora.