Brain level of pentobarbital is the primary determinant for the development of hypnotic of hypnotic tolerance in mice.
Controlling the duration of hypnotic effect of pentobarbital by simultaneously administered bemegride, the relationship between the duration of hypnosis and the degree of developed tolerance after acute or chronic treatment was investigated in mice. Bemegride attenuated the hypnotic effect of pentobarbital, but neither the brain level of pentobarbital nor the development of tolerance was modified by bemegride, indicating that the brain level of pentobarbital is the primary determinant for the production of tolerance and full duration of hypnosis is not essential in this mechanism.
D000818:Animals; D001534:Bemegride / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D004347:Drug Interactions; D004361:Drug Tolerance; D006991:Hypnosis, Anesthetic; D051379:Mice; D010424:Pentobarbital / Q000378:metabolism* / Q000494:pharmacology
D001534:Bemegride; D010424:Pentobarbital