[Teratogenic damage of the central nervous system during progressing embryogenesis].
The long-term development of the CNS and its fundamental processes represent the basis of the high sensitivity of neural structures also during postnatal phases of development. Successive teratological rows of the CNS can be produced by application of different teratogenic substances at different times of development. Different teratogenic agents produce different malformations at the same day of development. Each teratogenic substance cause agent specific effects. Histological methods reveal the changing sensitivity of neural structures after application of special teratogenic agents at different times of development.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D002490:Central Nervous System / Q000002:abnormalities* / Q000196:embryology; D003520:Cyclophosphamide / Q000009:adverse effects; D005865:Gestational Age; D015122:Mercaptopurine / Q000009:adverse effects; D051381:Rats; D013723:Teratogens / Q000494:pharmacology*; D014343:Trypan Blue / Q000009:adverse effects
D013723:Teratogens; D003520:Cyclophosphamide; D015122:Mercaptopurine; D014343:Trypan Blue
Teratogene Schädigungsmuster der Zentralnervensystems bie fortschreitendem Keimlingsalter.