Natural cytotoxic cells against solid tumors in mice. III. A comparison of effector cell antigenic phenotype and target cell recognition structures with those of NK cells.
Antisera directed to antigens present on natural killer (NK) cells such as Qa-2,3, Qa-5, NK-1.2, Ly 11.2, and Asialo GM 1 failed to eliminate natural cytotoxic (NC) cell activity from murine spleen cells, suggesting a heterogeneity of effector populations involved in natural cell-mediated cytotoxicity (NCMC). Cross-cold target inhibition studies demonstrated that certain similar recognition structures are present both on NK and NC susceptible tumor target cells.
D000818:Animals; D000941:Antigens; D000954:Antigens, Surface / Q000276:immunology; D003165:Complement System Proteins; D003602:Cytotoxicity, Immunologic; D005354:Fibrosarcoma / Q000276:immunology; D006168:Guinea Pigs; D007106:Immune Sera / Q000494:pharmacology; D008223:Lymphoma / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000276:immunology*; D010641:Phenotype; D011817:Rabbits
D000941:Antigens; D000954:Antigens, Surface; D007106:Immune Sera; D003165:Complement System Proteins