H-Y antigen expression in a case of XX true hermaphroditism.
Cells from an XX true hermaphrodite expressed a reduced amount of H-Y antigen when compared with normal XY cells and with cells from his father, who had an XY/XX chromosomal constitution. His mother had a normal karyotype and was H-Y negative. The four brothers of the patient were clinically and karyotypically normal. An X-Y interchange followed by random inactivation of the X chromosome is proposed to explain the H-Y antigen titer found in the patient.
D002675:Child, Preschool; D012734:Disorders of Sex Development / Q000235:genetics* / Q000276:immunology; D005260:Female; D006066:Gonads / Q000473:pathology; D006182:H-Y Antigen / Q000235:genetics*; D006801:Humans; D012729:Sex Chromosome Aberrations; D014178:Translocation, Genetic; D014960:X Chromosome
D006182:H-Y Antigen