title: Sister-chromatid exchanges induced in vitro by cyclophosphamide without exogenous metabolic activation in lymphocytes from three mammalian species.
abstract: The induction of sister-chromatid exchanges (SCEs) by cyclophosphamide (CP) in human, rat and rabbit lymphocytes was studied in vitro without exogenous metabolic activation. In contrast with published reports, CP induced SCEs in lymphocytes from all three species, indicating that cultured lymphocytes possess the metabolic capacity to convert this indirect-acting mutagen.
mesh_terms: D000818:Animals; D001711:Biotransformation; D003434:Crossing Over, Genetic / Q000187:drug effects*; D003520:Cyclophosphamide / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008741:Methyl Methanesulfonate / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D012854:Sister Chromatid Exchange / Q000187:drug effects*
chemical_list: D003520:Cyclophosphamide; D008741:Methyl Methanesulfonate