[Kanamycin deposition in the peritoneum as affected by dimexide].
The effect of dimexid (dimethylsulfoxide) on kanamycin absorption from the peritoneum was studied on normal albino rats with aseptic peritonitis. Contrary to the present opinion that the rate of various drug absorption into the blood increases under the effect of dimexid, it was shown that intraperitoneal administration of dimexid and kanamycin resulted in deposition of kanamycin in the peritoneum followed by its slow liberation into the blood channel. The concentration of kanamycin in the peritoneum increased 3--8 times under the effect of dimexid, thus prolonging its retention time by 10--13 hours. The depositing effect was more pronounced in the animals with peritonitis.
D000042:Absorption; D000818:Animals; D004121:Dimethyl Sulfoxide / Q000378:metabolism*; D004347:Drug Interactions; D007612:Kanamycin / Q000378:metabolism*; D007700:Kinetics; D010537:Peritoneum / Q000378:metabolism*; D010538:Peritonitis / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D007612:Kanamycin; D004121:Dimethyl Sulfoxide
Deponirovanie kanamitsina v briushine pod vliianiem dimeksida.