title: Steroid-induced ultrastructural changes in the proximal convoluted tubule cells of baboon kidneys with special reference to peroxisomes.
abstract: An electron microscopic study was performed on kidneys of immature female baboons, Papio hamadryas, that received a series of 10 consecutive weekly injections of the synthetic glucocorticoid, Triamcinolone hexacetonide (4 mg/kg body wt). In the steroid-treated kidneys the most distinctive change found is a significant increase in the number and a marked change in the form of peroxisomes (microbodies) in proximal convoluted tubule cells. These cells also develop hypertrophic mitochondria and in some instances mitochondrial hyperplasia is present to such a degree as to lead to the formation of "oxyphil-like" mitochondrion-rich cells, containing degenerating nuclei. Many proximal cells also develop large secondary lysosomes packed with fibrous contents. Our results indicate a morphological response in proximal tubule cells caused by the corticosteroid-treatment, though the responses seen may possibly be also due to the development of a secondary hyperparathyroidism.
mesh_terms: D000818:Animals; D005260:Female; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000648:ultrastructure; D008247:Lysosomes / Q000187:drug effects; D008830:Microbodies / Q000187:drug effects / Q000648:ultrastructure; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects; D010215:Papio; D014222:Triamcinolone Acetonide / Q000494:pharmacology*
chemical_list: D014222:Triamcinolone Acetonide