[Measurements of nerve conduction velocity during decreasing toxic diphenylhydantoin levels and the beginning of carbamazepine medication. A clinical neurophysiological documentation (author's transl)].
Sensory and motor nerve conduction velocity was determined daily in an epileptic patient during recovery of acute diphenylhydantoin toxicity and at the beginning of carbamazepine medication. A statistical correction, which accounts for the influence of variable skin temperatures on the sensory nerve conduction velocity (SNCV), proved to be useful for SNCV measurements of the sural nerves. We found significant correlation between the increasing sensory nerve conduction of the sural nerves and the decreasing diphenylhydantoin levels. During rising carbamazepine concentrations, we observed decreasing conduction velocities in peripheral nerves.
D002220:Carbamazepine / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000187:drug effects*; D009431:Neural Conduction / Q000187:drug effects*; D010672:Phenytoin / Q000009:adverse effects*; D012881:Skin Temperature
D002220:Carbamazepine; D010672:Phenytoin
Messungen der Nervenleitgeschwindigkeit beim Abklingen einer Diphenylhydantoinintoxikation und während des Beginns einer Carbamazepinmedikation. Eine klinisch-neurophysiologische Dokumentation.