title: Duplication 11p11.3 leads to 14.1 to meiotic crossing--over.
abstract: An infant with macular dysfunction, cleft lip and palate, and developmental delay was shown to have an inverted duplication of 11p11.3 leads to p14.1 on the basis of meiotic recombination subsequent to an intrachromosomal "shift" in his mother. A half-sister had previously been shown [3] to have the reciprocal recombinant with resultant deletion of 11p11.3 leads to 11p14.1.
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002906:Chromosomes, Human, 6-12 and X; D002971:Cleft Lip / Q000235:genetics; D002972:Cleft Palate / Q000235:genetics; D003434:Crossing Over, Genetic; D004261:DNA Replication; D003878:Dermatoglyphics; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D008540:Meiosis; D010641:Phenotype