Aneuploidy as a marker for carcinoma-in-situ of the testis.
A microspectrophotometric study of the DNA content of carcinoma-in-situ germ cells in the testes of eight infertile men revealed an aneuploid DNA distribution pattern. The results support the assumption that carcinoma-in-situ germ cells are of a malignant nature. The findings also indicate that the DNA content can be used to discriminate between carcinoma-in-situ germ cells and spermatogonia.
D000782:Aneuploidy; D002278:Carcinoma in Situ / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis*; D006801:Humans; D008297:Male; D013053:Spectrophotometry; D013736:Testicular Neoplasms / Q000473:pathology*; D013737:Testis / Q000473:pathology
D004273:DNA, Neoplasm