New indolic anti-tremor agents.
Twenty eight compounds have been synthesized in the series 2-substituted-3-[(N-alkanol-N-imidazolin-2'-ylamino)methyl]indoles. Some of them have been shown to protect mice from tremorine-induced tremors. The compounds are central nervous system depressants and relatively non-toxic.
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D005260:Female; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D014202:Tremor / Q000188:drug therapy*
D007211:Indoles