Norethisterone-4 beta,5-oxide and laevonorgestrel-4 beta,5-oxide: formation in rat liver microsomal incubations and interference with microsomal epoxide hydrolase and cytoplasmic glutathione S-transferase.
D000818:Animals; D002855:Chromatography, Thin Layer; D003593:Cytoplasm / Q000201:enzymology; D004851:Epoxide Hydrolases / Q000037:antagonists & inhibitors*; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D016912:Levonorgestrel / Q000031:analogs & derivatives*; D008297:Male; D013058:Mass Spectrometry; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D009152:Mutagenicity Tests; D009640:Norethindrone / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000494:pharmacology*; D009644:Norgestrel / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000494:pharmacology; D051381:Rats
D009644:Norgestrel; C022959:norethindrone-4 beta,5 beta-epoxide; C029212:levonorgestrel-4 beta,5 beta-epoxide; D016912:Levonorgestrel; D005982:Glutathione Transferase; D004851:Epoxide Hydrolases; D009640:Norethindrone