Effect of aspirin on gastric acid secretion in the rat.
The effects of aspirin on gastric acid and sodium have been studied in a perfused rat stomach preparation. In the pentagastrin-stimulated stomach, as intraluminal aspirin concentration increased, there was a significant fall in acid output together with a significant decrease in the loss of sodium from the gastric lumen. It was concluded that these observations were due to a back-diffusion effect resulting from disruption of the gastric mucosal barrier rather than parietal cell inhibition
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D001647:Bile Acids and Salts / Q000502:physiology; D004058:Diffusion; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects; D005947:Glucose / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D051381:Rats; D012964:Sodium / Q000502:physiology
D001647:Bile Acids and Salts; D012964:Sodium; D005947:Glucose; D001241:Aspirin