title: Fentanyl pharmacokinetics in awake volunteers.
abstract: A single intravenous dose of fentanyl (either 2 or 4 micrograms/kg body weight) was given to 13 healthy, young volunteer subjects. Serum fentanyl concentration decreased in a triexponential pattern. The terminal half-times were 750 and 853 minutes, respectively. A three-compartment, open, mammillary model is proposed for fentanyl kinetics.
mesh_terms: D000328:Adult; D005260:Female; D005283:Fentanyl / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008297:Male; D011485:Protein Binding; D012119:Respiration; D013997:Time Factors; D014851:Wakefulness
chemical_list: D005283:Fentanyl