The nucleus reticularis lateralis: a region highly sensitive to clonidine.
Slow bilateral microinjections of a low dose of clonidine (75 ng/kg) in the cat's nucleus reticularis lateralis (NRL) lead to significant hypotension and bradycardia. This finding confirms the existence of a ventromedullary highly sensitive site of action of clonidine. It is suggested that clonidine inhibits some vasopressive and cardioacceleratory structures within the NRL region.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects* / Q000502:physiology; D008845:Microinjections
D003000:Clonidine