[Aminoacetonitrile and fetogenesis of the rat. III. Malformations of the osseous skeleton (author's transl)].
The paper describes disturbances of ossification and malformations of the osseous skeleton of rat fetuses after application of 300 mg aminoacetonitrile/kg body weight during fetogenesis (days 15--19). Malformations are inducible at all days proved: Single doses of the lathyrogenic agent (intraperitoneally applicated) produce severe scoliosis, bending of extremities, wristdrop of the fore paws, shortening of the lower jaw, cleft palate and distorsion of the ribs. This paper is a continuation of 2 preceding parts dealing with general parameters of reproduction and gross anomalies after application of aminoacetonitrile, and disturbances of internal organ systems.
D000097:Acetonitriles / Q000009:adverse effects*; D000607:Aminoacetonitrile / Q000009:adverse effects*; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects; D002972:Cleft Palate / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects*; D051381:Rats; D012600:Scoliosis / Q000139:chemically induced
D000097:Acetonitriles; D000607:Aminoacetonitrile
Aminoacetonitril und Fetogenese der Ratte. III. Fehlbildungen des knöchernen Skelettes.