The pharmacological effect of fractions obtained by smoking cannabis through a water-pipe. II. A second fractionation step.
The catatonic activity, prolongation of phenobarbital sleeping-time, convulsant action and disruption of nest-building activity was assessed in mice subjected to 4 cannabis pyrolysis products and their tobacco analogues. All but one of the cannabis fractions prolonged the pentobarbital sleeping-time and disrupted the nest-building activity of mice in a way not related to their content in the main cannabinoids. Nest-building activity seems to be the most valid assay we have used so far.
D000818:Animals; D000927:Anticonvulsants; D001522:Behavior, Animal / Q000187:drug effects*; D002186:Cannabinoids / Q000302:isolation & purification / Q000494:pharmacology*; D006358:Hot Temperature; D008297:Male; D051379:Mice; D009425:Nesting Behavior / Q000187:drug effects; D010947:Plants, Toxic; D012890:Sleep / Q000187:drug effects; D012906:Smoke; D014026:Nicotiana
D000927:Anticonvulsants; D002186:Cannabinoids; D012906:Smoke