title: Progressive supranuclear palsy: pneumoencephalography, electronystagmography and treatment with methysergide.
abstract: 15 patients with progressive supranuclear palsy (PSP) are presented with discussion of the value of pneumoencephalography (PEG) and electronystagmography (ENG) in confirming the diagnosis. PEG was performed in 6 patients, and revealed atrophy in the area of the pons and colliculi. ENG, which also was performed in 6 patients, 4 of whom had PEG, confirmed the defects in extraocular movement. Methysergide, which has been suggested as therapy for PSP, was utilized in 6 patients with no evidence of significant improvement.
mesh_terms: D000368:Aged; D001480:Basal Ganglia Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D004584:Electronystagmography; D005260:Female; D006801:Humans; D008297:Male; D008784:Methysergide / Q000627:therapeutic use*; D008875:Middle Aged; D011011:Pneumoencephalography; D012438:Saccades
chemical_list: D008784:Methysergide