Corticosteroid effect on murine hemopoietic precursor cells in vivo.
The effect of methylprednisolone on murine hemopoietic colony formation in diffusion chambers implanted in mice was evaluated. A dose-dependent increase in granulocytic colony (CFU-DG) formation from murine marrow was observed. This effect could be abrogated by administration of progesterone. These studies suggest that the murine early granulocytic precursors (CFU-DG) have receptors that mediate proliferation-promoting signals triggered by glucocorticoids. Erythroid colony formation (CFU-DE) was not effected by methylprednisolone administration.
D000818:Animals; D001665:Binding Sites; D003114:Colony-Forming Units Assay; D004305:Dose-Response Relationship, Drug; D005260:Female; D005938:Glucocorticoids / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D008775:Methylprednisolone / Q000494:pharmacology*; D051379:Mice; D011374:Progesterone / Q000494:pharmacology
D005938:Glucocorticoids; D011374:Progesterone; D008775:Methylprednisolone