title: [Maximal response of the rat vas deferens. III. Effect of compounds with various pharmacological activities on the response to noradrenaline].
abstract: A study has been made of the action on the rat vas deferens response to noradrenalin of the following substances: cocaine, phentolamine and dihydroergocrystine; pronethalol, dichloroisopropylnoradrenalin, propranolol, N-isopropyl-p-nitrophenylethanolamine; d-chlorpheniramine; cimetidine; amitryptyline. With the exception of the beta-adrenolytic agents and cimetidine, all the compounds tested independently of their "principal" pharmacological action showed a property in common with the local anesthetics: depending on dose they were able to increase or decrease the maximal response to noradrenalin. These effects were correlated with variations in the state of stabilization of the membrane.
mesh_terms: D000818:Animals; D004347:Drug Interactions; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D014649:Vas Deferens / Q000187:drug effects
chemical_list: D009638:Norepinephrine
vernacular_title: Studio delle risposte massimali del vas deferens di ratto. Nota III - Azione di sostanze a vario profilo farmacodinamico sulla risposta alla noradrenalina.