High frequency of HLA-B27 and Reiter's syndrome in Navajo Indians.
Eighteen cases of Reiter's syndrome were found in a population of approximately 6,000 Navajo Indians. The phenotype frequency of HLA-B27 in this population was found to be 36%. The area in which these people live is endemic for shigellosis, Shigella flexneri being the most common species isolated. Presumably the high frequency of HLA-B27 and shigella infections account for the high incidence and prevalence of Reiter's syndrome in this population.
D001130:Arizona; D016918:Arthritis, Reactive / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D007198:Indians, North American; D008297:Male
D006680:HLA Antigens