Isolated defect in human placental lactogen synthesis in a normal pregnancy. Case report.
A deficiency in the synthesis of human placental lactogen (hPL) was found in a woman in her second pregnancy. Other placental hormone levels were normal. The woman gave birth to a healthy female infant. hPL deficiency is rare and a survey of the literature has revealed only one previous case report which described the birth of a male infant. The present report of a hPL deficiency is the first associated with the birth of a normal female infant.
D000328:Adult; D006063:Chorionic Gonadotropin / Q000096:biosynthesis; D046508:Culture Techniques; D004964:Estriol / Q000096:biosynthesis; D005260:Female; D006801:Humans; D010920:Placenta / Q000378:metabolism; D010928:Placental Lactogen / Q000096:biosynthesis / Q000172:deficiency*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*
D006063:Chorionic Gonadotropin; D010928:Placental Lactogen; D004964:Estriol