Role of complement in viral infections: participation of terminal complement components (C5 to C9) in recovery of mice from Sindbis virus infection.
the pathogenesis of Sindbis virus infection was studied in congenic mice with normal levels of the fifth component of complement (C5) and in mice deficient in C5. Mice deficient in C5 had a higher mortality rate than mice with normal levels of C5 as well as impaired clearance of virus from their brain and feet.
D000818:Animals; D001102:Arbovirus Infections / Q000276:immunology*; D001921:Brain / Q000276:immunology / Q000382:microbiology; D003182:Complement C5 / Q000276:immunology*; D003186:Complement C9 / Q000276:immunology*; D004660:Encephalitis / Q000276:immunology; D005528:Foot / Q000276:immunology / Q000382:microbiology; D051379:Mice; D012845:Sindbis Virus / Q000032:analysis; D010948:Viral Plaque Assay; D014779:Virus Replication
D003182:Complement C5; D003186:Complement C9