title: Cholesteryl ester hydrolase activity in human symptomatic atherosclerosis.
abstract: Acid cholesteryl ester hydrolase (CEH) activity was assayed in mononuclear cells of patients with symptomatic atherosclerosis (transient ischemic attacks, TIA) and in age-matched controls showing no evidence of atherosclerosis. The acid CEH level of TIA patients was significantly lower than that of controls (1074 +/- 128 vs 2113 +/- 255 pmol/mg P/hr, mean +/- SE). Neither mononuclear cell nor plasma cholesterol and cholesteryl ester concentrations differed significantly between atherosclerotic and control groups. TIA women had lower mononuclear cell concentrations of free cholesterol than men.
mesh_terms: D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000201:enzymology; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D002788:Cholesterol Esters / Q000097:blood; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D012737:Sex Factors; D002787:Sterol Esterase / Q000097:blood*
chemical_list: D002788:Cholesterol Esters; D002784:Cholesterol; D002265:Carboxylic Ester Hydrolases; D002787:Sterol Esterase