title: Studies on cardioactive steroids. V. Structure-activity relationships of derivatives of 16 alpha-gitoxin.
abstract: The potency of 17 derivatives of 16 alpha-gitoxin was tested in the isolated atrium and heart of the guinea pig and the contractility-increasing activity of the 16 alpha-gitoxin 16 alpha-acetate was compared with that of 16 alpha-gitoxin in the anesthetized dog. The potency of 16 alpha-gitoxin was increased by the substitution of 16 alpha-OH for 16 alpha-methyl ether, 16 alpha-acetate and 16 alpha-nitrate. Substitution of the 16 alpha-acetyl group for substituents with a higher molar volume diminished this enhanced potency. Variation in the digitoxose moiety caused an increase or decrease in potency depending on the position and number of the substituted OH groups. In spite of changes in 16 alpha-OH, the low influence on rhythmicity persisted, as was found in experiments in the dog.
mesh_terms: D000113:Acetyldigoxins / Q000494:pharmacology; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D002301:Cardiac Glycosides; D004077:Digoxin / Q000494:pharmacology* / Q000031:analogs & derivatives; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D007536:Isomerism; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D013268:Stimulation, Chemical; D013329:Structure-Activity Relationship
chemical_list: D000113:Acetyldigoxins; D002301:Cardiac Glycosides; C025972:16-acetylgitoxin; D004077:Digoxin; C005003:gitoxin