[Effect of neuromediators on NADH oxidation in rat brain tissue].
It is shown that noradrenaline and serotonin have an influence on NADH-oxidation (increase or decrease) in the rat brain mitochondria and microsomes. The effects depend on various conditions: concentration, their combination with each other, etc. Acetylcholine has no effect on this process as well as on some dehydrogenases investigated previously but it can change the effect of other compounds. It may be proposed that acetylcholine, being inactive itself, serves as a modulator of the action of other compounds (noradrenaline, serotonin).
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008297:Male; D008861:Microsomes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D009243:NAD / Q000378:metabolism*; D009638:Norepinephrine / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*
D009243:NAD; D012701:Serotonin; D000109:Acetylcholine; D009638:Norepinephrine
Vliianie neĭromediatorov na okislenie NADH v tkani golovnogo mozga krys.