title: Angiocardiography with metrizamide in the neonate and infant.
abstract: The non-ionic contrast medium metrizamide was compared with a routine ionic medium (sodium methyl-glucamine diatrizoate) in a series of 16 patients with congenital heart disease, all under 11 kg body weight, undergoing angiocardiography. Despite a higher viscosity, metrizamide yielded images of equal quality to those of the ionic medium, and was clinically better tolerated. Metrizamide produced a significantly lesser effect on plasma osmolality, a parameter closely related to contrast medium toxicity. Other biochemical parameters showed insignificant changes. Metrizamide is therefore a more suitable contrast medium for angiocardiography and despite its cost should be considered for patients with serious congenital heart disease who are in poor clinical condition.
mesh_terms: D000790:Angiocardiography; D003974:Diatrizoate Meglumine; D006330:Heart Defects, Congenital / Q000097:blood / Q000000981:diagnostic imaging*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008793:Metrizamide / Q000009:adverse effects
chemical_list: D003974:Diatrizoate Meglumine; D008793:Metrizamide