Cross-tolerance between D-amino acids and morphine in mice.
The effects of morphine administration on analgesia and running activity were studied in DBA/2 (DBA) and C57BL/6 (C57) mice respectively, injected with D-amino acids (D-AA) for 5 days. The results indicate a clear cross-tolerance between D-AA and morphine in DBA mice when analgesia is considered, while the stimulating effect of the opiate is not modified after D-AA pretreatment in the C57 strain.
D000818:Animals; D004361:Drug Tolerance; D007930:Leucine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects; D010649:Phenylalanine / Q000494:pharmacology*; D013237:Stereoisomerism
D010649:Phenylalanine; D009020:Morphine; D007930:Leucine