title: Liver disease in rheumatoid arthritis.
abstract: Patients with active rheumatoid arthritis frequently have hepatosplenomegaly and biochemical features of hepatic disease. A prospective study with liver biopsy has been carried out in a series of 31 rheumatoid arthritis patients with clinical and/or biochemical evidence of hepatic dysfunction. Four of the 31 (13%) were found to have definable chronic liver disease, normal hepatic histology or non-specific reactive changes being found in the remainder. In the large majority of patients the hepatic abnormality in rheumatoid arthritis remains functional and unexplained.
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury; D006801:Humans; D008107:Liver Diseases / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D000893:Anti-Inflammatory Agents