[Synthesis of 4-ureidooxycyclophosphamide (author's transl)].
The synthesis of 4-ureidooxycyclophosphamide, a potential cytostatic, whose cis/trans-isomers can be stereoselectively obtained from 4-hydroxycyclophosphamide and hydroxyurea in DMF in DMF or water, is described. These compounds are remarkably stable at room temperature. For the first time, the two epimers from a derivative of 4-hydroxycyclophosphamide can be NMR-spectroscopically compared with each other.
D055598:Chemical Phenomena; D002621:Chemistry; D003520:Cyclophosphamide / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D009682:Magnetic Resonance Spectroscopy; D013237:Stereoisomerism
C035012:4-ureidooxycyclophosphamide; D003520:Cyclophosphamide
Synthese von 4-Ureidooxycyclophosphamid.