The effect of carbenoxolone on the chronic atrophic gastric mucosa determined by flow cytometry and histoautoradiography.
A trial with carbenoxolone at a dose of 150 mg/day for 6 months was performed in 24 patients with chronic atrophic gastritis. A control group of 21 patients received placebos. Gastric mucosa was examined by flow cytometry (FC) and histoautoradiography 2, 4, 12 and 24 weeks after starting therapy. Carbenoxolone had neither an effect on cell cycle stage distribution as determined by FC nor on the labelling indices obtained by histoautoradiography.
D000328:Adult; D000368:Aged; D001345:Autoradiography; D002229:Carbenoxolone / Q000494:pharmacology / Q000627:therapeutic use*; D002453:Cell Cycle; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology*; D005756:Gastritis / Q000188:drug therapy*; D005757:Gastritis, Atrophic / Q000188:drug therapy* / Q000473:pathology; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives*; D006801:Humans; D007700:Kinetics; D008875:Middle Aged
D002229:Carbenoxolone; D006034:Glycyrrhetinic Acid