title: Relating plasma levels of clomipramine and clinical response.
abstract: This paper examines some of the recent results published on the relationship between steady-state plasma concentrations and clinical response. Results are given from three studies of clomipramine all failing to demonstrate an association between steady-state plasma clomipramine levels and clinical response both measured as effect--change in severity of depression using the GPCRG rating scale--and side-effect.
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D002997:Clomipramine / Q000009:adverse effects / Q000097:blood* / Q000627:therapeutic use; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects; D003863:Depression / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012907:Smoking
chemical_list: D003278:Contraceptives, Oral, Hormonal; D002997:Clomipramine