[Familial diabetes insipidus of central origin (author's transl)].
In a 10-year-old girl admitted to hospital for polyuria and polydipsia, the central nervous system origin of the symptoms was demonstrated by low antidiuretic hormone levels (inferior to 1 pg/ml) and reduction of diuresis after administration of 1-deamino-8D-arginine-vasopressin (DDAVP). A study of the girl's family history showed that the disease was hereditary and autosomal dominant. Intranasal instillations of DDAVP twice daily constitute the best known treatment of the condition.
D002648:Child; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage; D003919:Diabetes Insipidus / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000235:genetics*; D004231:Diuresis / Q000187:drug effects; D005260:Female; D006801:Humans; D007223:Infant; D010375:Pedigree; D014667:Vasopressins / Q000172:deficiency
D014667:Vasopressins; D003894:Deamino Arginine Vasopressin
Diabète insipide familial d'origine centrale.