Repair of human DNA in molecules that replicate or remain unreplicated following ultraviolet irradiation.
The extent of DNA replication, the incidence of UV induced pyrimidine dimers and the repair replication observed after their excision was monitored in human fibroblasts UV irradiated with single or split UV doses. The excision repair processes were measured in molecules that remained unreplicated or in those that replicated after the latter UV irradiation. Less DNA replication was observed after a split as opposed to single UV irradiation. Furthermore, a split dose did not modify the excision parameters measured after a single irradiation, regardless of whether the DNA had replicated or not.
D004247:DNA / Q000528:radiation effects; D004260:DNA Repair; D004261:DNA Replication / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts; D006801:Humans; D011740:Pyrimidine Dimers / Q000378:metabolism; D013997:Time Factors; D014466:Ultraviolet Rays
D011740:Pyrimidine Dimers; D004247:DNA