[On the pharmacokinetics and bioavailability of paracetamol in suppositories for paediatry (author's transl)].
In a comparative study on the pharmacokinetics of two paracetamol suppository preparations (A = Kinder-Tylenol, B = reference compound as a commercial preparation), serum levels were determined in 10 healthy male volunteers between 23 and 32 years over 12 h at 11 measurement points. Aim of the trial was to examine the bioavailability, the absorption and elimination rate as well as the distribution volume for both preparations. After application of both suppository preparations the serum levels revealed that the absorption from prep. A was more than twice as fast (k1 = 0.762 h-1) as that from prep. B (k1 = 0.348 h-1), resulting in an obviously higher maximum blood level. The bioavailability values are also higher when prep. A is administered (123% versus prep. B).
D000082:Acetaminophen / Q000008:administration & dosage / Q000378:metabolism*; D000328:Adult; D001682:Biological Availability; D006801:Humans; D007700:Kinetics; D008297:Male; D010372:Pediatrics; D012007:Rectum; D013488:Suppositories; D013997:Time Factors
D013488:Suppositories; D000082:Acetaminophen
Zur Pharmakokinetik und bioverfügbarkeit von Paracetamol in suppositorien für die Pädiatrie.