title: Effect of choline on central dopaminergic function in normal subjects.
abstract: Oral administration of choline (10 g) had no effect on basal serum growth hormone or prolactin concentrations in normal subjects (N = 5). Choline significantly enhanced the increase in growth hormone secretion induced by apomorphine HCl (0.5 mg s.c.). These data suggest that cholinergic mechanisms may enhance hypothalamic-pituitary dopaminergic function in man in contrast to their inhibitory effect on dopaminergic function in the basal ganglia.
mesh_terms: D000328:Adult; D001058:Apomorphine / Q000494:pharmacology; D002794:Choline; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000502:physiology*; D008297:Male; D011388:Prolactin / Q000097:blood*
chemical_list: D011388:Prolactin; D013006:Growth Hormone; D001058:Apomorphine; D002794:Choline