Radioresponse of peripheal blood and its modification by MPG (2-mercaptopropionylglycine) in mice. I. Erythrocytes.
Radiation-induced peripheral blood erythrocyte changes were studied in male Swiss albino mice after whole-body exposure to different doses of gamma-radiation (250 R, 500 R and 1000 R) with or without the drug, MPG. MPG did not have any effect on the initial cell depression, but it afforded significant protection at later intervals with sublethal gamma doses (250 R and 500 R). However, after lethal exposure (1000 R) the drug did not show any protective effect.
D000603:Amino Acids, Sulfur / Q000494:pharmacology*; D000818:Animals; D004912:Erythrocytes / Q000528:radiation effects*; D008297:Male; D051379:Mice; D011829:Radiation Dosage; D011837:Radiation-Protective Agents; D008625:Tiopronin / Q000494:pharmacology*
D000603:Amino Acids, Sulfur; D011837:Radiation-Protective Agents; D008625:Tiopronin