[The metabolism of halothane under the influence of thiopental, methohexital, etomidate, enflurane and disulfiram under clinical conditions (author's transl)].
The biotransformation of halothane is supposed to be the cause of the rare "halothane-hepatitis". Therefore an inhibition of the metabolism of Halothane is of some interest. We used bromide as a metabolite of Halothane and investigated the bromide level of the serum of patients after halothane anaesthesia by means of x-ray fluorescence spectrometry. The induction of anaesthesia with Thiopental, Methohexital and Etomidate had no influence on the bromide level. Likewise the influence of Enflurane on the metabolism of Halothane was not significant. An effective inhibitor in man is Disulfiram. The authors assume, that further information about the toxicity of Halothane metabolites can be gained through further studies of drugs like Disulfiram.
D000293:Adolescent; D000328:Adult; D000758:Anesthesia; D001711:Biotransformation; D004221:Disulfiram / Q000494:pharmacology; D004347:Drug Interactions; D004737:Enflurane / Q000494:pharmacology; D005045:Etomidate / Q000494:pharmacology; D006221:Halothane / Q000378:metabolism*; D006801:Humans; D008723:Methohexital / Q000494:pharmacology; D008875:Middle Aged; D013874:Thiopental / Q000494:pharmacology
D004737:Enflurane; D008723:Methohexital; D013874:Thiopental; D004221:Disulfiram; D006221:Halothane; D005045:Etomidate
Der Halothanstoffwechsel unter dem Einfluss von Thiopental, Methohexital, Etomidat, Enflurance und Disulfiram bei klinischen Bedingungen.