title: Tamm-Horsfall protein in lymph nodes.
abstract: We found masses of amorphous waxy pale staining material in the peripheral sinuses of lymph nodes removed with renal tumors. The material was histochemically and immunohistochemically identical to Tamm-Horsfall protein. It was found also in tubular casts, renal tubules, and intrarenal lymphatics in the resected kidneys. Tamm-Horsfall protein was restricted to the compressed residual kidney and was not seen in the tumors. Under certain circumstances Tamm-Horsfall protein escapes from the tubules into the renal interstitium and may produce a local inflammatory reaction. It also gains access to intrarenal lymphatics and thence to regional lymph nodes. This may be relevant to the evolution of an antibody response.
mesh_terms: D001323:Autoantibodies / Q000032:analysis; D002648:Child; D006801:Humans; D007106:Immune Sera; D007684:Kidney Tubules / Q000378:metabolism; D008198:Lymph Nodes / Q000032:analysis*; D008856:Microscopy, Fluorescence; D009088:Mucoproteins / Q000032:analysis* / Q000096:biosynthesis; D058949:Uromodulin
chemical_list: D001323:Autoantibodies; D007106:Immune Sera; D009088:Mucoproteins; C548612:UMOD protein, human; D058949:Uromodulin