title: The embolization of bone wax from sternotomy incisions.
abstract: We discuss our study on the effects of discontinuation of the usage of bone wax as a hemostatic agent in sternotomy incisions. In 1976, we abandoned use of bone wax because it was suspected of causing several cases of Mycobacterium fortuitum sternal osteomyelitis. In a retrospective study involving 400 patients, we found that this step did not increase postoperative bleeding as measured by drainage from the chest tube and by the need to return patients to the operating room because of bleeding. It also was observed that there was an appreciable simultaneous drop in pulmonary complications. To test our theory that the wax pressed into the bone marrow can embolize to the lung, radioactively tagged bone wax was pressed into the cut sternum in animal models, and a search was made for radioactive deposits in the peripheral lung tissue. Shortly after the application of the wax, there was evidence of large radioactive deposits in the lungs. It is probable that this embolization occurs also under clinical conditions and may play a role in pulmonary complications following open-heart operations.
mesh_terms: D000818:Animals; D004285:Dogs; D006490:Hemostatics / Q000009:adverse effects*; D006801:Humans; D010019:Osteomyelitis / Q000209:etiology; D011655:Pulmonary Embolism / Q000209:etiology*; D011859:Radiography; D013249:Sternum / Q000000981:diagnostic imaging / Q000601:surgery*; D013909:Thorax / Q000098:blood supply; D014683:Vena Cava, Superior / Q000000981:diagnostic imaging; D014885:Waxes / Q000009:adverse effects*
chemical_list: D006490:Hemostatics; D014885:Waxes