Hepatic and renal effects of low concentrations of methoxyflurane in exposed delivery ward personnel.
During five alternating three-week periods either methoxyflurane-nitrous oxide or nitrous oxide alone was used for obstetrical analgesia. Delivery ward personnel were followed by venous blood samples once a week. Analyses of blood urea nitrogen, serum uric acid, SGOT and SGPT showed significantly elevated levels three days after exposure to methoxyflurane. This study demonstrates the importance of the scavenging of anesthetic gases to reduce the exposure of personnel to inhalational agents used in delivery suites. Since definite alterations in the indices of both hepatic and renal functions were recognized in obstetrical personnel following exposure, a re-evaluation of the use of methoxyflurane for obstetrical analgesia is suggested.
D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001806:Blood Urea Nitrogen; D056486:Chemical and Drug Induced Liver Injury; D004781:Environmental Exposure; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*; D008733:Methoxyflurane / Q000009:adverse effects*; D009775:Obstetrics and Gynecology Department, Hospital; D010564:Personnel, Hospital; D013997:Time Factors; D014527:Uric Acid / Q000097:blood
D014527:Uric Acid; D008733:Methoxyflurane; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase