Mathematical analysis of the oncornavirus maturation process (virion RNA conversion and morphological condensation).
The rate of the maturation process of avian myeloblastosis virus experimentally estimated on the basis of genomic viral RNA conversion and morphological transition of virions was mathematically analysed. Three mathematical models were suggested and fitted to experimental data. It was found that: (a) model of simple kinetics (Model 1) does not agree with experimental data. Therefore, two hypotheses were considered in further mathematical modelling: (b) virions are identical in time of budding: maturation is dependent on the presence of a virion component which is degraded with time (Model 2). This model agrees with experimental data in all stages of the maturation process. (c) Virions are released from cells at different stages of assembly (Model 3). This model differs from experimental data especially in early stages of maturation. The hypothesis used for the construction of Model 2 seems to be the most plausible to explain the maturation process and is in agreement with data of murine leukemia virus maturation which was found to be accomplished by cleavage of p70 precursor protein.
D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D012367:RNA, Viral / Q000235:genetics; D012190:Retroviridae / Q000254:growth & development*; D014771:Virion / Q000254:growth & development
D012367:RNA, Viral