Alterations in drug induced catalepsy and post-decapitation convulsions following brain and spinal cord depletion of norepinephrine by the neurotoxin DSP-4.
The effects of central norepinephrine depletion produced by DSP-4 on drug-induced catalepsy and pot-decapitation convulsions were examined in the rat. Haloperidol-induced catalepsy was potentiated in DSP-4 treated rats, while arecoline-induced catalepsy was attenuated. Furthermore, post-decapitation convulsions were eliminated in DSP-4 treated animals. DSP-4 may prove to be a useful tool with which to investigate the behavioral consequences of damage to the locus coeruleus noradrenergic system.
D000588:Amines / Q000494:pharmacology*; D000818:Animals; D001115:Arecoline / Q000494:pharmacology; D001596:Benzylamines / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D002375:Catalepsy / Q000139:chemically induced* / Q000378:metabolism; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008297:Male; D009498:Neurotoxins / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000378:metabolism*; D013116:Spinal Cord / Q000187:drug effects*
D000588:Amines; D001596:Benzylamines; D009498:Neurotoxins; D001115:Arecoline; D006220:Haloperidol; C012102:DSP 4; D009638:Norepinephrine