Dopamine-activated adenylate cyclase of spinal cord: supersensitivity following transection of the cord.
A dopamine-activated adenylate cyclase has been identified in a membrane fraction of rat spinal cord. The concentration of dopamine producing half-maximal activation is about 5 microM and the activation is blocked by haloperidol. Apomorphine also activates the cyclase. Following transection of the cord, adenylate cyclase becomes about 5-10 times more sensitive to dopamine below the transection. The presence of dopamine-activated adenylate cyclase in the cord is consistent with reports of dopamine-containing tracts in spinal cord. This neuronal system may play an essential role in normal spinal mechanisms, in disease associated with dopaminergic neurons, as well as in the side-effects of neuroleptic drugs.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002462:Cell Membrane / Q000201:enzymology; D004298:Dopamine / Q000494:pharmacology*; D004789:Enzyme Activation; D006220:Haloperidol / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013116:Spinal Cord / Q000201:enzymology* / Q000502:physiology
D011433:Propranolol; D000262:Adenylyl Cyclases; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine