Breed differences in nutritionally induced hyperlipoproteinemia in the rabbit.
The influence of a high-fat, cholesterol-free diet on the lipoprotein pattern is compared in New Zealand hyperresponder and Fauve de Bourgogne hyporesponder rabbits. Quantitative as well as qualitative differences were observed. The high-fat diet induces an increase in both LDL and HDL in the Fauve de Bourgogne, the ratio VLDL + LDL/HDL cholesterol being unchanged. By contrast, New Zealand rabbits present a greater increase in plasma cholesterol which is mainly transported by the VLDL and the LDL. Consequently the proportion of HDL cholesterol is markedly decreased. The breed difference in response to the diet is also noted in lipoproteins composition since only New Zealand rabbits show abnormal VLDL. These results are discussed in terms of differences in susceptibility to experimental atherosclerosis reported between the two strains.
D000818:Animals; D002784:Cholesterol / Q000097:blood; D004041:Dietary Fats; D005227:Fatty Acids; D006951:Hyperlipoproteinemias / Q000209:etiology*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008099:Liver / Q000032:analysis; D008297:Male; D011817:Rabbits
D004041:Dietary Fats; D005227:Fatty Acids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D002784:Cholesterol