Continuous lines of basophil/mast cells derived from normal mouse bone marrow.
Nonadherent tissue culture cell lines were established from normal bone marrow of a variety of mouse strains. The lines possessed morphological and histochemical markers of the basophil/mast cell and contained committed stem cells for metachromatic cells. Their derivation from normal marrow and their lack of tumorigenicity despite long-term culture makes these cell lines potentially important for studies of the mechanisms of allergic reactions and inflammation as well as the differentiation pathways involving this subset of hematopoietic cells.
D000818:Animals; D001491:Basophils; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D002460:Cell Line; D046508:Culture Techniques; D006412:Hematopoietic Stem Cells; D006651:Histocytochemistry; D008407:Mast Cells; D051379:Mice; D008815:Mice, Inbred Strains