Adriamycin-induced decrease of myocardial contraction reserve in rats treated with dobutamine.
Muscle-mechanical and hemodynamic properties were measured in adriamycin-treated rats and in untreated controls. The respective parameters in both animal groups could not be distinguished at rest. Using a pharmacological stress test with dobutamine a differentiation of both groups was possible: the concentration-response curve of papillary muscles from ADM-rats was lower and shifted towards higher concentrations when compared with the respective curve of untreated animals. The maximum hemodynamic response following an i.v. bolus injection of dobutamine was considerably decreased in ADM-rats as compared to untreated rats. It is concluded that the estimation of impaired myocardial function due to adriamycin might be more accurate when the contraction reserve is evaluated.
D000818:Animals; D002395:Catecholamines / Q000494:pharmacology*; D004280:Dobutamine / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D010210:Papillary Muscles / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D002395:Catecholamines; D004280:Dobutamine; D004317:Doxorubicin