[Influence of curare and methohexital-Na on the content of energy-rich phosphates and substrates of glycolysis in rat liver (author's transl)].
Our investigations demonstrate that 7',12'-dihydroxy-6,6'-dimethoxy-2,2,2',2'-tetramethyl-tubocuraranium dihydroxide (D-tubocurarine, Curarin-Asta), in the following briefly called curare, and methohexital sodium influence glycolysis and energy metabolism of rat liver cells. Within the first 5 min after i.v. application of curare we observed a decrease of ATP levels due to either increased energy demands during cellular metabolism or to a decrease of ATP production in the respiratory chain. This effect was followed by an activation of glycolysis as demonstrated by a decrease of cytoplasmic glycogen and an increase of glucose-6-phosphate. Simultaneously, cytoplasmic lactate levels were increased and redox potentials significantly shifted. The latter effect is caused by alterations in the lactate-pyruvate ratios. In contrast, methohexital sodium induced a significant increase of cellular ATP levels. The observed low lactate-pyruvate ratio and the changes in the adenylate system following methohexital sodium suggest that this drug reduces energy consumption during cellular metabolism.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D003472:Curare / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D006019:Glycolysis / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008723:Methohexital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013696:Temperature
D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D003472:Curare; D000255:Adenosine Triphosphate; D008723:Methohexital
Der Einfluss von Curare und Methohexital-Na auf den Gehalt an energiereichen Phosphaten und Glykolysesubstraten in der Rattenleber.