title: Development of antiviral levels of ribavirin in serum and urine of orally treated rats.
abstract: The levels of ribavirin or its antivirally active metabolic products were determined in the serum and urine of rats treated with single oral doses of 1,000 or 100 mg/kg of the compound, using a newly developed micromethod in which measles virus inhibition was assayed in BS-C-1 cells. At the high dosage level, maximum ribavirin serum levels of 24 microgram/ml were observed 2 h postribavirin administration. Approximately 10-fold less active material was seen in the rats receiving the lower ribavirin dosage; this peak effect was seen 1 h after treatment. Urine excretion was maximal between 4 and 20 h after treatment in both dosage groups.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D005260:Female; D007700:Kinetics; D051381:Rats; D012254:Ribavirin / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D012263:Ribonucleosides / Q000378:metabolism*
chemical_list: D012263:Ribonucleosides; D012254:Ribavirin