Inhibition of mast-cell degranulation by chemotactic peptides.
Pepstatin and f-methionyl peptides which are potent chemotactic agents for neutrophils were found to inhibit the increase in vascular permeability of rat skin which follows the injection of 48/80, anti-rat IgE serum, or pulmonary permeability factor. These latter compounds are known to act by releasing histamine from mast cells. f-Met-Leu-Phe, which is the most active chemotactically, was also found to be the most active inhibitor.
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D002417:Cattle; D003594:Cytoplasmic Granules / Q000276:immunology*; D006632:Histamine / Q000494:pharmacology; D007073:Immunoglobulin E; D008168:Lung / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000276:immunology*; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology*; D010436:Pepstatins / Q000494:pharmacology; D051381:Rats; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D010436:Pepstatins; D007073:Immunoglobulin E; D003189:p-Methoxy-N-methylphenethylamine; D009240:N-Formylmethionine Leucyl-Phenylalanine; D006632:Histamine