Paradoxical effect of high and low dose aspirin in experimental arterial thrombosis.
The effect of different dosage regimens of aspirin was investigated in an experimental model of arterial thrombosis. A paradoxical effect with an increase of the arterial thrombus growth could be seen after a first single dose of 100 mg aspirin/kg body weight. When the high dose of aspirin was given repeatedly, a thrombus size minor than under low dose aspirin therapy with 10 mg/kg body weight has been observed. Our experimental thrombosis experiments do not provide sufficient evidence to support antithrombotic therapy with low doses of aspirin.
D000818:Animals; D001012:Aorta, Abdominal; D001158:Arteries; D001241:Aspirin / Q000494:pharmacology*; D001777:Blood Coagulation; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D011817:Rabbits; D013927:Thrombosis / Q000503:physiopathology*
D001241:Aspirin