Phagocytic cells in glomerular cultures from NZB/W mice.
Comparative studies of glomerular cultures from NZB/W and normal control mice aged 2, 4, 6, 8, 10 and 12 months revealed a significant increase in the number of phagocytic cells in cultures from NZB/W mice at all ages. These cells on electron microscopy had the appearance of macrophages and on immunofluorescence showed Fc receptors and reacted with rabbit anti-mouse macrophage serum. The cells appear to be of blood monocyte origin and it is likely that they play a role in the pathogenesis in NZB/W mice of the glomerulopathy associated with clearance of immune complexes.
D000818:Animals; D046508:Culture Techniques; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology / Q000473:pathology*; D007678:Kidney Glomerulus / Q000276:immunology / Q000648:ultrastructure*; D007958:Leukocyte Count; D051379:Mice; D008814:Mice, Inbred NZB; D008855:Microscopy, Electron, Scanning; D010586:Phagocytes / Q000276:immunology / Q000648:ultrastructure*; D010587:Phagocytosis; D011961:Receptors, Fc / Q000032:analysis
D011961:Receptors, Fc