Antisickling agents as inhibitors of glucose transport in human erythrocytes.
It was found that 2-amino-3-indolepropionic acid (tryptophan) and 2-amino-3-phenylpropionic acid (phenylalanine) benzylesters, compounds which inhibit cell sickling, are inhibitors of glucose transport in normal human erythrocytes. The mechanism underlying both processes is discussed.
D000596:Amino Acids / Q000494:pharmacology; D000986:Antisickling Agents / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics
D000596:Amino Acids; D000986:Antisickling Agents; D001786:Blood Glucose