[Modifications of electromechanical coupling in the rabbit myocardium following cholesterol-oil diet during changing Ca2+ supply].
To characterize the electromechanical coupling in rabbit myocardium after a 12 weeks lasting lipid-rich diet the influence of increasing extracellular Ca2+ on isometric contractions of isolated trabeculae has been investigated. Only after lipid-rich diet the Ca2+-induced augmentation in isometric tension was accompanied by an increase in a Vmax equivalent, in the index of contractility dk/dtmax divided by K', and in the relaxation index -dk/dtmax divided by K. The results correspond with changes in the sarcoplasmic reticulum function reflected in a higher Ca2+ accumulating ability of isolated microsomes.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006368:Helianthus; D006949:Hyperlipidemias / Q000503:physiopathology; D009200:Myocardial Contraction; D009821:Oils; D011817:Rabbits
D002791:Cholesterol, Dietary; D009821:Oils; D002118:Calcium
Veränderungen der elektromechanischen Ankopplung im Kaninchenmyokard nach Cholesterol-Ol-Diät bei wechselndem Ca2+-Angebot.