title: The median subcallosal fasciculus in the monkey: a unique prefrontal corticostriate and corticocortical pathway revealed by anterogradely transported horseradish peroxidase.
abstract: Using the remarkable capability of tetramethylbenzidine (TMB) neurohistochemistry to delinate anterogradely transported horseradish peroxidase (HRP) following HRP gel implants in the prearcuate prefrontal cortex of macaque and cebus monkeys, this study revealed bilateral projections to the caudate nucleus and inferior parietal lobule that followed the median subcallosal fasciculus, a rostrocaudally running, midline trajectory located between the body of the corpus callosum and the fornix. This seemingly aberrant fascicle runs through the septum pellucidum from the genu to the splenium of the corpus callosum, and gives off fibers bilaterally to the body of the caudate nucleus and inferior parietal lobule. The description of this unique pathway re-emphasizes the close relationship that exists between the granular frontal and inferior parietal cortices, and the striatum, and explains earlier observations based upon silver degeneration and autoradiographic studies, of prefrontal corticofugal projections to the septum and fornix.
mesh_terms: D000818:Animals; D002421:Caudate Nucleus / Q000033:anatomy & histology; D002427:Cebidae / Q000033:anatomy & histology*; D002428:Cebus / Q000033:anatomy & histology*; D003337:Corpus Callosum / Q000033:anatomy & histology; D005625:Frontal Lobe / Q000033:anatomy & histology*; D006735:Horseradish Peroxidase; D008251:Macaca / Q000033:anatomy & histology*; D009434:Neural Pathways; D010296:Parietal Lobe / Q000033:anatomy & histology; D012688:Septum Pellucidum / Q000033:anatomy & histology
chemical_list: D006735:Horseradish Peroxidase