title: Non-invasive measurement of cardiac output during anaesthesia. An evaluation of the soluble gas uptake method.
abstract: A technique for measuring cardiac output which depends on the uptake of an inert soluble gas from the lungs has been evaluated during anesthesia. A respiratory mass spectrometer has been used to follow the concentrations of argon and freon-22 during passive rebreathing in anaesthetized patients before cardiopulmonary bypass. Values for cardiac output obtained with this technique are reproducible, but lower than those recorded using the direct Fick technique before and after the rebreathing manoeuvre. A reduction in cardiac output caused by vigorous rebreathing is the most likely explanation for the discrepancy and, although serial measurements of oxygen consumption may permit application of a correction factor, a method of measurement which causes significant haemodynamic disturbance cannot be recommended for widespread use.
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D001128:Argon; D002302:Cardiac Output; D002315:Cardiopulmonary Bypass; D005617:Chlorofluorocarbons, Methane; D005260:Female; D006334:Heart Function Tests / Q000379:methods; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D010101:Oxygen Consumption; D011652:Pulmonary Circulation
chemical_list: D005617:Chlorofluorocarbons, Methane; D001128:Argon