Anesthetic barbiturates in refractory status epilepticus.
Two patients with previous cerebral damage and seizures and three patients with acute inflammatory cerebral lesions developed status epilepticus. They were unresponsive to standard anticonvulsants, but anesthetic barbiturates (thiopental and pentobarbital) stopped the seizures promptly.
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D001921:Brain / Q000378:metabolism; D005260:Female; D005971:Glutamates / Q000378:metabolism; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D010424:Pentobarbital / Q000627:therapeutic use*; D012640:Seizures / Q000378:metabolism; D013226:Status Epilepticus / Q000188:drug therapy*; D013874:Thiopental / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000927:Anticonvulsants; D005971:Glutamates; D005680:gamma-Aminobutyric Acid; D010424:Pentobarbital; D013874:Thiopental