Teratogenic effects of Nicotiana glauca and concentration of anabasine, the suspect teratogen in plant parts.
Nicotiana glauca consumption by pregnant cows or sows produced arthrogryposis and other congenital deformities in their offspring. The plant material administered contained 0.11% anabasine, the suspect teratogen. But concentration varied among various plant parts; woody material was very low but leaves and bark were high. The anabasine was identified by mass spectral fragmentation analysis.
D000691:Anabasine / Q000032:analysis*; D000818:Animals; D001176:Arthrogryposis / Q000209:etiology / Q000662:veterinary; D002417:Cattle; D002418:Cattle Diseases / Q000209:etiology*; D000013:Congenital Abnormalities / Q000662:veterinary*; D005260:Female; D010880:Piperidines / Q000032:analysis*; D010939:Plant Poisoning / Q000150:complications / Q000662:veterinary*; D010947:Plants, Toxic / Q000032:analysis; D011247:Pregnancy; D013552:Swine; D013553:Swine Diseases / Q000209:etiology*; D013723:Teratogens / Q000032:analysis*
D010880:Piperidines; D013723:Teratogens; D000691:Anabasine