Human platelet stimulation by acetyl glyceryl ether phosphorylcholine.
Acetyl glyceryl ether phosphorylcholine (AGEPC) induced dose-dependent platelet aggregation and release of [3H]serotonin and platelet factor 4 in citrated human platelet-rich plasma. ADP scavengers or indomethacin prevented irreversible platelet aggregation responses induced by 0.2 microM AGEPC but had no effect upon platelet secretion; prostacyclin inhibited AGEPC-induced aggregation and secretion. EDTA or EGTA inhibited AGEPC-induced aggregation but had no effect on platelet secretion.
D001779:Blood Coagulation Factors / Q000378:metabolism*; D001792:Blood Platelets / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008244:Lysophosphatidylcholines / Q000494:pharmacology*; D010972:Platelet Activating Factor; D010974:Platelet Aggregation / Q000187:drug effects*; D010978:Platelet Factor 4 / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors
D001779:Blood Coagulation Factors; D008244:Lysophosphatidylcholines; D010972:Platelet Activating Factor; D012701:Serotonin; D010978:Platelet Factor 4