Experimental evidence of increased ipsilateral gentamicin nephrotoxicity after unilateral ureteral obstruction.
This study describes an experimental model for the investigation of nephrotoxicity in which the aminoglycoside, gentamicin, is given after unilateral ureteral obstruction is produced. The preliminary findings indicate a significantly more severe loss of renal function in the obstructed kidney which receives gentamicin than in the obstructed kidney which does not.
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis; D000818:Animals; D005839:Gentamicins / Q000009:adverse effects*; D007444:Inulin; D007677:Kidney Function Tests; D008297:Male; D051381:Rats; D014517:Ureteral Obstruction / Q000188:drug therapy*
D005839:Gentamicins; D007444:Inulin