title: Sequence and organization of the human mitochondrial genome.
abstract: The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.
mesh_terms: D001483:Base Sequence; D005075:Biological Evolution; D003062:Codon; D004261:DNA Replication; D004272:DNA, Mitochondrial / Q000235:genetics*; D005796:Genes; D006801:Humans; D009694:Nucleic Acid Precursors / Q000378:metabolism; D010442:Peptide Chain Initiation, Translational; D010443:Peptide Chain Termination, Translational; D012335:RNA, Ribosomal / Q000235:genetics; D012343:RNA, Transfer / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D003062:Codon; D004272:DNA, Mitochondrial; D009694:Nucleic Acid Precursors; D012335:RNA, Ribosomal; D012343:RNA, Transfer