GABA depletion in chick brain-stem after intraventricular injection of cefazolin.
The effects of cefazolin, given into the III cerebral ventricle at different doses were studied on GABA content, GAD and GABA-T in the brain-stem of young chickens (Gallus domesticus). A dose-dependent fall in GABA content was observed; GABA decrease was evident 15 min after the administration, reached its nadir at 60 min and disappeared at 120 minutes. Glutamate decarboxylase and GABA-transaminase activity were not significantly changed. Present experiments suggest the excitatory and convulsant effects of cefazolin in chicks are related to GABA depletion in the brain-stem.
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism; D000818:Animals; D001933:Brain Stem / Q000187:drug effects* / Q000378:metabolism; D002437:Cefazolin / Q000008:administration & dosage / Q000494:pharmacology*; D002645:Chickens; D005968:Glutamate Decarboxylase / Q000378:metabolism; D007276:Injections, Intraventricular; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D000612:4-Aminobutyrate Transaminase; D005968:Glutamate Decarboxylase; D002437:Cefazolin