title: Enhancement of the phototherapy effect of albumin in Gunn rats. Investigations on the optimal albumin dose.
abstract: In pharmacokinetic studies we proved that the efficacy of phototherapy in jaundiced Gunn rats was enhanced by administration of human albumin. The albumin injections provoked a bilirubin shift from extravascular compartments into the circulation. In this study, calculations on the optimal albumin dose were carried out. After s.c. injections a good effect could be ascertained with doses between 2 and 4 g/kg body weight. After i.v. injections effective plasma concentrations could be maintained for an acceptable time by about 2g albumin/kg body weight. When overdoses were given, a considerable amount of albumin was eliminated very quickly--especially after i.v. injections with the rapid rise of the plasma level. Clinical implications are discussed.
mesh_terms: D000418:Albumins / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D005110:Extracellular Space; D006932:Hyperbilirubinemia / Q000628:therapy*; D007565:Jaundice / Q000628:therapy; D010789:Phototherapy; D051381:Rats
chemical_list: D000418:Albumins