Temperature dependence of ethanol depression in mice.
The relationship between environmental temperature, body temperature and ethanol depression was investigated in male C57BL/6J mice. Animals were injected with ethanol (3.6 g/kg) or saline and placed in an experimental or normal room temperature (control) environment. Environmental temperatures from 12-37 degrees C significantly influenced rectal temperature, sleep-time and wake-up brain ethanol concentrations. The rectal temperatures of ethanol-treated animals ranged from 1.5 degrees C greater to 11.3 degrees C lower than their matched saline controls, supporting indications that ethanol impairs normal thermoregulation. Sleep-time decreased up to 43% and wake-up brain ethanol concentrations increased as rectal temperature decreased from approximately 38-32 degrees C. More severe hypothermia after ethanol (rectal temperature less than 29 degrees C) increased sleep-time and decreased wake-up brain ethanol concentrations. These results indicate that sleep-time and brain sensitivity to ethanol vary with rectal temperature in accordance with predictions based on membrane expansion and partition theories of anesthesia and the anticipated anesthetic-like actions of severe hypothermia.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002492:Central Nervous System Depressants; D000431:Ethanol / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D004856:Postural Balance / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D013696:Temperature
D002492:Central Nervous System Depressants; D000431:Ethanol