title: Functional consequences of expanded aortic bulb: a model study.
abstract: An investigation of the mechanical effects and physiological functions of the dilated ascending aorta of diving mammals was undertaken with mathematic modeling methods. A mathematical model of a prototype (canine) arterial system was constructed and was evaluated by comparing model-predicted pressure and flow wave forms at four vascular locations with published accounts of experimental measurements. The prototype model was modified to serve as a model of the diving mammal arterial system by changing peripheral vascular parameters and by changing the dimensions of the ascending aorta section of the model. This modified model gave a very good simulation of pressure and flow behavior in diving mammal arteries during a dive. Various distribution patterns of compliance addition to the prototype aortic pattern were evaluated as to the effect of these patterns on aortic input properties. It was concluded that the geometric distribution pattern found in diving mammal arteries was optimal with respect to reducing aortic impedance and peak systolic pressure development and thus favored the function of the left ventricle. This mechanical function could represent an important part of the total picture of adaptation to prolonged ischemia.
mesh_terms: D000818:Animals; D001011:Aorta / Q000502:physiology*; D003187:Compliance; D004242:Diving; D004548:Elasticity; D006801:Humans; D008433:Mathematics; D008954:Models, Biological