title: Interaction of insecticides with human plasma lipoproteins.
abstract: The binding of chlorinated hydrocarbon, carbamate and organophosphate insecticides to human low density plasma lipoproteins (LDL) and high density plasma lipoproteins (HDL) was studied at pH 7.0 and 16 degrees C and 26 degrees C by equilibrium dialysis, difference spectra and fluorescence. The results suggest interaction to be a partitioning rather than a stoichiometric binding process. Distribution is related to lipid content and composition of the lipoproteins. The K-values vary from 3 x 10(5)M-1 for 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) to less than 10 M-1 for nicotine and aldicarb, and delta G degrees tr is in the range of 7400 cal for DDT to less than 1000 cal for aldicarb and nicotine. The K and delta G degrees tr are inversely related to the water solubility of the insecticides. A significant role of plasma lipoproteins in the transport of slightly water soluble insecticides is suggested.
mesh_terms: D006801:Humans; D066298:In Vitro Techniques; D007306:Insecticides / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D011485:Protein Binding; D013050:Spectrometry, Fluorescence; D013053:Spectrophotometry / Q000379:methods
chemical_list: D007306:Insecticides; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL