[Modifications of the respiratory mechanism induced by administration of 18, 19, 20-trinor-17-cyclohexyl-13, 14-dehydro PGF 2 alpha methyl ester].
The effects on pattern of breathing, on compliance and respiratory resistances of PGF 22 were investigated in anaesthetized pigs before and after vagosympathectomy. A marked increase in respiratory resistance and a decrease in lung compliance simultaneously with a pulmonary congestion were observed. The respiratory changes were considered secondary both to a vagal reflex and to the hemodynamic impairment.
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D015237:Dinoprost / Q000031:analogs & derivatives*; D005260:Female; D008170:Lung Compliance / Q000187:drug effects; D008297:Male; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D011654:Pulmonary Edema / Q000139:chemically induced; D012137:Respiratory System / Q000187:drug effects*; D013552:Swine; D013562:Sympathectomy; D014628:Vagotomy
D011461:Prostaglandins F, Synthetic; C029284:18,19,20-trinor-17-cyclohexyl-13,14-dehydroprostaglandin F2alpha methyl ester; D015237:Dinoprost
Modificazioni della meccanica respiratoria indotte dalla somministrazione di 18,190,20-trinor-17-cicloesil-13,14-deidro PGF 2 alfa metilestere.