title: Pharmacokinetics of terbutaline and theophylline in guinea pigs when administered simultaneously.
abstract: Simultaneous administration of terbutaline and theophylline to guinea pigs did not cause significant alterations of the pharmacokinetic properties of any of the drugs. Terbutaline sulphate 24 microgram kg-1 and aminophylline 52 mg kg-1 (7.42 . 10(-8) and 2.37 . 10(-4) mol kg-1 respectively) were given by a bolus intravenous injection, producing plasma concentrations in the range 0-15 ng terbutaline sulphate per ml (0-46 nanomol 1(-1)) and 10-85 microgram theophylline per ml (50-429 mumol 1(-1)). Pharmacokinetic analyses of time courses of plasma concentrations of intact drugs and investigations of tissue distribution 1 hour after the administration were performed. The results showed a weak, statistically insignificant trend of the peripheral compartment of the 2-compartment model to sequester a larger fraction of the drugs when these were administered simultaneously.
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D013726:Terbutaline / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D013806:Theophylline / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D013806:Theophylline; D013726:Terbutaline