title: Erythrocytotoxicity induced by cancer chemotherapeutic agents. In vitro studies of osmotic fragility and methaemoglobin generation.
abstract: Increased osmotic fragility and methaemoglobin generation in vitro have resulted from the exposure of normal human erythrocytes to numerous cancer chemotherapeutic agents. These findings offer a possible explanation for the earlier, consistent clinical observation of the rapid development of anaemia, during consolidation therapy, in children with acute lymphoblastic leukaemia in remission.
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008706:Methemoglobin / Q000378:metabolism*; D009996:Osmotic Fragility / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D008706:Methemoglobin