[Synthesis of 1-aroyl-4H(R)-thiosemicarbazides, the corresponding 5-aryl 4H(R)-1,2,4-triazolin-3-thiones and some derivatives of pharmaceutical interest].
A series of 1-aroyl-4H(R)-thiosemicarbazides (IV-XVIII) and the corresponding 5-phenyl-4H(R)-1,2,4-triazolin-3-thiones (XIX-XXXIII) were synthesized: biological assay demonstrated their in vitro antibacterial and antimycotic activities. The preparation of same hydrazinoaroylthiazoles (XXXIV-XXXVI) was reported also, obtained by condensation of 1-aroyl-4H-thiosemicarbazides with phenacyl bromide and the synthesis of thiazole[3,2-b]-s-triazol-3(2H)-ones (XLIX-LI) prepared by cyclodehydration of carboxymethylthiotriazoles (XLVI-XLVIII). The results of pharmacological testing for both series of derivatives (XLIX-LI) and (XLVI-XLVIII) showed good antiinflammatory and antipyretic activities.
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D008297:Male; D051381:Rats; D012663:Semicarbazides / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000890:Anti-Infective Agents; D012663:Semicarbazides; D014230:Triazoles
Sintesi di 1-aroil-4H(R)-tiosemicarbazidi, dei corrispondenti 5-aril-4H(R)-1,2,4-triazolin-3-tioni e di alcuni derivati di interesse farmaceutico.