Effect of phosphoenolpyruvate on liver mitochondrial calcium retention from fed and fasted rats.
Rat liver mitochondria from fed and 4-day-fasted rats are able to accumulate calcium supported by ATP (energy-driven calcium uptake) or by succinate (respiration-driven calcium uptake). Phosphoenolpyruvate decreases the amount of calcium accumulated in both ways, whether the rats were fasted or fed ad libitum. Phosphoenolpyruvate induces a net calcium efflux from mitochondria. The effect of phosphoenolpyruvate is partially reversed by ADP. Phosphoenolpyruvate is also able to inhibit the ATP-driven calcium accumulation in the absence of exogenously added respiratory substrates.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism*; D005215:Fasting; D005260:Female; D007700:Kinetics; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010728:Phosphoenolpyruvate / Q000494:pharmacology*; D051381:Rats; D013386:Succinates / Q000378:metabolism
D013386:Succinates; D000244:Adenosine Diphosphate; D010728:Phosphoenolpyruvate; D000255:Adenosine Triphosphate; D002118:Calcium