title: Studies on amphistomiasis in Andhra Pradesh (India) VI. Immunization of lambs and kids with gamma irradiated metacercariae of Cercariae indicae XXVI.
abstract: The life span and the pathogenicity of amphistomes developing from Cercariae indicae XXVI (Paramphistomum epicilitum) were considerably reduced when the metacercariae were gamma-irradiated at 2 krad or 3 krad. The higher irradiation dose resulted in the complete absence of the flukes in infected animals. Single vaccination of lambs and kids with 3000 metacercariae irradiated at 2 krad or 3 krad stimulated a significant degree of resistance against challenge with 5000 non-irradiated metacercariae. The resistance was more pronounced in the group vaccinated with metacercariae irradiated at 3 krad.
mesh_terms: D000818:Animals; D005720:Gamma Rays; D006041:Goats / Q000469:parasitology*; D007114:Immunization; D007194:India; D008297:Male; D012756:Sheep / Q000469:parasitology; D012757:Sheep Diseases / Q000276:immunology*; D014200:Trematoda / Q000276:immunology* / Q000528:radiation effects; D014201:Trematode Infections / Q000276:immunology / Q000662:veterinary*