Complementation between a gene of the I-E subregion and a non-H-2 gene in the class-specific suppression of IgG2a antibody to sheep erythrocytes.
A low level of IgG2a antibodies is observed in B10 mice after primary immunization with SRBC. Analysis of the response in different H-2b mice and among B10 animals with different H-2 haplotypes reveals that this selective isotype deficiency is under the control of at least two genes: a background gene and an H-2-linked gene. Responses of H-2 recombinant B10 strains map the H-2-linked gene to the 1-E subregion. Evidence is presented for complementation between H-2 and non-H-2 genes in the determination of the low responder phenotype. Low responsiveness appears to be inherited as a dominant trait. Possible functions of the two series of genes are discussed in relation to suppressor mechanisms.
D000818:Animals; D000918:Antibody Specificity; D002874:Chromosome Mapping; D004306:Dose-Response Relationship, Immunologic; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D005796:Genes; D005799:Genes, Dominant; D006183:H-2 Antigens / Q000235:genetics; D006238:Haploidy; D007074:Immunoglobulin G / Q000096:biosynthesis* / Q000145:classification; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D012756:Sheep
D006183:H-2 Antigens; D007074:Immunoglobulin G