[Enhanced alpha adrenoreceptor-mediated vasoconstrictor component in essential hypertension].
Changes in forearm blood flow in response to infusions of the postsynaptic alpha blocking agent prozosin (0.5 microgram/min/100 ml forearm tissue) and of the nonspecific vasodilating drug sodium nitroprusside (0.6 microgram/min/100 ml forearm tissue) into the brachial artery were assessed in 24 patients with essential hypertension (EHT) and in 16 age-matched normotensive subjects (NT). Under basal conditions forearm blood flow was higher in EHT (4.0 +/- 0,2 vs. 2.6 +/- 0.3 ml/min/100 ml forearm tissue, p less than 0.001). Forearm blood flow response to prazosin was greater in EHT than in NT (7.7 +/- 0.8 vs. 2.6 +/- 0.3, p less than 0.001) while sodium nitroprusside responses were similar in EHT and NT (13.8 +/- 0.8 vs 13.0 +/- 0.8 vs. 13.0 +/- 0.1, n.s.). These results indicate an enhanced alpha adrenoceptor-mediated vasoconstrictor component in EHT and help to explain the effectiveness of antihypertensive drugs which interfere with sympathetic control of vascular resistance.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D004357:Drug Synergism; D005260:Female; D005292:Ferricyanides / Q000494:pharmacology*; D005542:Forearm / Q000098:blood supply; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009599:Nitroprusside / Q000494:pharmacology*; D011224:Prazosin / Q000494:pharmacology*; D011799:Quinazolines / Q000494:pharmacology*; D012039:Regional Blood Flow; D014655:Vascular Resistance / Q000187:drug effects*
D005292:Ferricyanides; D011799:Quinazolines; D009599:Nitroprusside; D011224:Prazosin
Verstärkte alpha-adrenozeptor-vermittelte Vasokonstriktion bei essentieller Hypertonie.