Interaction of alpha-L-aspartyl-D-phenylalanine methyl ester with the receptor site of the bitter taste.
The analysis of the structure-activity relationship previously performed on the sweet L,L isomer of Asp-Phe-OMe was extended to the bitter L,D diastereoisomer. A combination of NMR measurements and of an original method of PEM calculations gives a description of the conformational state of the L,D isomer that can be effectively used to study the interaction with a previously proposed model of the bitter taste receptor site.
D001218:Aspartame / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology*; D006801:Humans; D008968:Molecular Conformation; D011984:Sensory Receptor Cells / Q000187:drug effects*; D013649:Taste / Q000187:drug effects*
D004151:Dipeptides; D001218:Aspartame