The effect of a liquid elemental diet on cell proliferation in the colon of rats.
A liquid elemental diet (Vivonex) was given to rats for 6 days while control animals received a normal diet. At the end of the experiment each animal received one intraperitoneal injection of tritiated thymidine at 8 a.m. Animals from each group were killed hourly during the first 24 h after the injection and the proliferative activity was studied by autoradiography of the mucosa of the colon using the labeled mitoses-wave method. The epithelial cell proliferation was significantly decreased in the colon of the Vivonex-fed animals.
D000818:Animals; D002453:Cell Cycle; D002455:Cell Division; D003106:Colon / Q000166:cytology*; D004247:DNA / Q000096:biosynthesis; D004032:Diet; D007413:Intestinal Mucosa / Q000166:cytology*; D008297:Male; D051381:Rats
D004247:DNA