title: Analysis of animal weight gains in chronic toxicity studies.
abstract: The growth pattern of an animal or group of animals during a chronic toxicity study can be used in a a number of ways. Perhaps the most important uses are for prediction of future weights and as evidence of toxic effects. In this paper a model for animal weight gain is constructed and analyzed. Tests and interval estimates are constructed for comparison of growth patterns. It is shown that the asymptotic weight limit of a growth curve is a parameter with which meaningful inferences may be made. Finally, the model is applied to experimental data collected at the National Center for Toxicological Research.
mesh_terms: D000818:Animals; D001560:Benzidines / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D005260:Female; D008297:Male; D008433:Mathematics; D051379:Mice; D008954:Models, Biological; D013045:Species Specificity; D013997:Time Factors; D014116:Toxicology / Q000379:methods
chemical_list: D001560:Benzidines; C029876:benzidine