Urinary metabolites of chloroprocaine studied by combined gas chromatography--mass spectrometry.
The purpose of this study was to identify the metabolic pathway of 2-chloro-4-aminobenzoic acid (CABA), a primary metabolite of chloroprocaine. Urine was collected from 4 healthy, pregnant women following the epidural administration of 600 mg chloroprocaine. The urinary metabolites were extracted with ether and identified and quantitatively estimated with a gas chromatography--mass spectrometry instrument. The analysis showed that CABA is converted to N-acetyl-CABA and subsequently excreted in the urine.
D000779:Anesthetics, Local / Q000378:metabolism*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D011343:Procaine / Q000031:analogs & derivatives* / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000652:urine
D000779:Anesthetics, Local; D011343:Procaine; D005680:gamma-Aminobutyric Acid; C004616:chloroprocaine; C029210:2-chloro-4-aminobenzoic acid