Plasma levels and pharmacokinetics of cyclofenil after oral administration to man.
Cyclofenil was given as a single oral dose of 200 mg, and also as 200 mg/day for eight days, to seven healthy female volunteers. Plasma was analyzed for the active metabolite and pharmacokinetic modelling was performed. A biological half life of 29 h was bound after the single dose and 18 h after the eighth day of continuous treatment. No significant difference was found in any of the calculated parameters when comparing the values from Day 1 and Day 8. The theoretically constructed steady-state curve fitted the experimented values.
D000284:Administration, Oral; D000328:Adult; D003408:Cresols / Q000378:metabolism*; D003506:Cyclofenil / Q000097:blood / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D008875:Middle Aged
D003408:Cresols; D003506:Cyclofenil