Combined idiopathic neutropenia and thrombocytopenia: evidence for an immune basis for the syndrome.
We report a case of combined idiopathic immune neutropenia and immune thrombocytopenia (thromboneutropenia). Therapy with prednisone was ineffective. Treatment with vincristine raised the patient's platelet count but did not increase the neutrophil count. Splenectomy led to a prompt complete remission. Using radioimmunologic techniques, we have shown both antiplatelet and antineutrophil antibodies and have shown the disappearance of these antibodies after successful treatment.
D000293:Adolescent; D000380:Agranulocytosis / Q000150:complications*; D000906:Antibodies / Q000032:analysis; D001792:Blood Platelets / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D009503:Neutropenia / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D010976:Platelet Count; D011241:Prednisone / Q000627:therapeutic use; D013156:Splenectomy; D013577:Syndrome; D013921:Thrombocytopenia / Q000150:complications* / Q000276:immunology; D014750:Vincristine / Q000627:therapeutic use
D000906:Antibodies; D007074:Immunoglobulin G; D014750:Vincristine; D011241:Prednisone