title: Metabolism of imipramine by microorganisms.
abstract: The microbial metabolism of imipramine was studied using selected fungal organisms. The major microbial metabolites were isolated, and their structures were established by spectroscopic analyses (particularly 13C-NMR) and by comparison with authentic samples. The microbial metabolites identified included 2-hydroxyimipramine, 10-hydroxyimipramine, iminodibenzyl, imipramine-N-oxide, and desipramine; these metabolites also have been found in mammalian metabolism studies.
mesh_terms: D001711:Biotransformation; D005285:Fermentation; D005658:Fungi / Q000378:metabolism*; D007099:Imipramine / Q000378:metabolism*
chemical_list: D007099:Imipramine