title: Evaluation of 99mTc-labeled iminodiacetic acid derivatives of substituted 2-aminopyrroles as hepatobiliary imaging agents. I.
abstract: N-(3-Cyano-4,5-dimethyl-2-pyrrylcarbamoylmethyl)iminodiacetic acid (IIa) and N-(3-cyano-4-methyl-5-benzyl-2-pyrrylcarbamoylmethyl)iminodiacetic acid (IIb) were synthesized, labeled with technetium 99m, and compared with 99mTc-labeled p-isopropylacetanilidoiminodiacetic acid (I) for hepatobiliary activity in rats. All three compounds showed similar clearance of radioactivity from the blood. Comparison of the amount of radioactivity in various organs 1 hr after injection showed no significant difference between I and IIb. Compound IIa showed significantly less radioactivity in the GI tract and a higher amount in the kidneys and bladder.
mesh_terms: D000818:Animals; D001659:Biliary Tract / Q000000981:diagnostic imaging*; D005069:Evaluation Studies as Topic; D007098:Imino Acids / Q000378:metabolism; D008099:Liver / Q000000981:diagnostic imaging*; D008297:Male; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D051381:Rats; D013667:Technetium / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D007098:Imino Acids; D015609:Organotechnetium Compounds; C027059:technetium Tc 99m CDPCIDA; C027060:technetium Tc 99m CMBPIIDA; D013667:Technetium