MPG protection against radiation sickness and weight loss and its correlation with mortality of mice after whole-body gamma-irradiation.
The radiation-induced mortality together with the loss of body-weight and development of radiation sickness was studied in young adult Swiss albino mice after exposure to 1500 R of 60Co gamma-radiation in the presence and absence of 2-mercaptopropionyl-glycine (MGP), and results from both the groups were compared. It was found that the time of onset of radiation sickness was delayed in the drug-treated group, the mean survival time was also increased to 6 days as compared to 4.5 days in the untreated control group. These changes showed a direct correlation with the body-weight changes as the loss of weight in the drug-treated group was less marked and more gradual than in the untreated controls.
D000603:Amino Acids, Sulfur / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight; D051379:Mice; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D008625:Tiopronin / Q000494:pharmacology*
D000603:Amino Acids, Sulfur; D011837:Radiation-Protective Agents; D008625:Tiopronin