[Clinical pharmacokinetics and the optimal intravenous ampicillin administration regimen in children].
Nineteen children aged 3 months to 3 years were treated with ampicillin for acute pneumonia. The drug pharmacokinetics after a single intravenous administration in a dose of 25 mg/kg was studied. The data of the antibiotic pharmacokinetics in blood serum specimens collected within 3 hours after the drug injection were approximated with the use of the two-compartmental model, which proved to be more adequate than the one-compartmental model. The average period of the antibiotic half-life was 37 minutes and the value of the total clearance was 7.3 ml/min . kg. The optimal regimen for ampicillin administration, i. e. intravenous infusion of the antibiotic at a rate of 70 microgram/min . kg and its administration in a loading dose of 3.5 mg/kg was calculated with the use of the constants of the two-compartmental model. Clinical trials of the above regimen showed satisfactory conformity of the factual and calculated levels of the antibiotic in the blood serum of 7 children.
D000667:Ampicillin / Q000008:administration & dosage / Q000097:blood*; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007263:Infusions, Parenteral; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D013997:Time Factors
D000667:Ampicillin
Klinicheskaia faramakokinetika i optimal'nyĭ rezhim vnutrivennogo vvedeniia ampitsillina u deteĭ.