Degradation of 4-chlorophenylacetic acid by a Pseudomonas species.
Pseudomonas sp. strain CBS3 was able to utilize 4-chlorophenylacetic acid as the sole source of carbon and energy. When this strain was grown with 4-chlorophenylacetic acid, homoprotocatechuic acid was found to be an intermediate which was further metabolized by the meta-cleavage pathway. Furthermore, three isomers of chlorohydroxyphenylacetic acid, two of them identified as 3-chloro-4-hydroxyphenylacetic acid and 4-chloro-3-hydroxyphenylacetic acid, were isolated from the culture medium. 4-Hydroxyphenylacetic acid was catabolized in a different manner by the glutathione-dependent homogentisate pathway. Degradation enzymes of both of these pathways were inducible.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000302:isolation & purification / Q000378:metabolism; D004790:Enzyme Induction; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010648:Phenylacetates / Q000302:isolation & purification / Q000378:metabolism*; D011549:Pseudomonas / Q000201:enzymology / Q000378:metabolism*
D010648:Phenylacetates; D015102:3,4-Dihydroxyphenylacetic Acid; C029716:4-chlorophenylacetic acid; C029718:3-chloro-4-hydroxyphenylacetic acid; C008070:4-hydroxyphenylacetic acid; C029717:4-chloro-3-hydroxyphenylacetic acid; D006899:Mixed Function Oxygenases