Effect of actinomycin D on serum betalipoproteins of partially hepatectomized dogs. I. Proteins, lipids, triglycerides and cholesterol.
Effect of partial hepatectomy on serum and its betalipoprotein protein, lipids, triglycerides, free and esterified cholesterol in dogs has been studied up to 48 hrs after surgery. Effect of actinomycin D has also been studied on the serum and betalipoprotein, lipids, triglycerides, free and esterified cholesterol in regenerating dog liver. Partial hepatectomy generally reduced the concentration of above components of serum and betalipoprotein. However, administration of actinomycin D to partially hepatectomized dogs tended to prevent the decrease in serum and betalipoprotein components observed in hepatectomized dogs. The effect of actinomycin D was more pronounced on serum and betalipoprotein esterified cholesterol, concentration which were increased as compared to partially hepatectomized dogs.
D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL; D003609:Dactinomycin / Q000494:pharmacology*; D004285:Dogs; D006498:Hepatectomy; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D008115:Liver Regeneration / Q000187:drug effects; D008297:Male; D014280:Triglycerides / Q000097:blood
D001798:Blood Proteins; D008078:Cholesterol, LDL; D008055:Lipids; D008077:Lipoproteins, LDL; D014280:Triglycerides; D003609:Dactinomycin; D002784:Cholesterol