Results of oophorectomy by menstrual and estrogen receptor states in patients with metastatic breast cancer.
The records of 204 women with metastatic breast carcinoma treated by oophorectomy were analyzed. Premenopausal women had a response rate of 50 percent. Forty-one percent of postmenopausal women responded. Those who responded had an average duration of response of 22 months and a length of survival twice that of the nonresponders. There was a better than 60 percent correlation between response to oophorectomy and response to further endocrine ablation. Response to endocrine manipulation is more a function of the hormonal sensitivity of the carcinoma than of menopausal status.
D001943:Breast Neoplasms / Q000503:physiopathology / Q000556:secondary / Q000628:therapy*; D002369:Castration; D005260:Female; D006801:Humans; D008593:Menopause; D008598:Menstruation; D011960:Receptors, Estrogen / Q000502:physiology*
D011960:Receptors, Estrogen