Clinical trials of broad spectrum anthelmintics against soil-transmitted helminthiasis.
Clinical trials on the three broad spectrum anthelmintics against trichuriasis, ascariasis and hookworm infection were carried out in a rural community in Irosin, Sorsogon. Flubendazole (Fluvermal) appears to be a promising drug against trichuriasis particularly when periodic mass treatment of a community is carried out. Mebendazole (Antiox) also appears to be promising given as single dose during mass treatment of soil-transmitted helminthiasis. As shown in previous studies, oxantel-pyrantel (Quantrel) should be given at 15 mg/kg body weight at 12-hour intervals or 20 mg/kg body weight single dose rather than 10 mg/kg body weight in a single dose when treating trichuriasis.
D000871:Anthelmintics / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations / Q000627:therapeutic use; D004341:Drug Evaluation; D005243:Feces / Q000469:parasitology; D006801:Humans; D008463:Mebendazole / Q000031:analogs & derivatives / Q000627:therapeutic use; D010679:Philippines; D011715:Pyrantel / Q000031:analogs & derivatives / Q000627:therapeutic use; D012987:Soil; D014257:Trichuriasis / Q000188:drug therapy*
D000871:Anthelmintics; D004338:Drug Combinations; D012987:Soil; C029857:quantrel; D011715:Pyrantel; D008463:Mebendazole; C018945:flubendazole