title: [Physics of biological pattern formation].
abstract: In each generation cycle of a higher organism, a complex structure if formed under the instruction of the genes. In this process morphogenetic fields (probably spatial concentration patterns of substances) are involved which elicit cell responses giving rise to visible pattern and form. Autocatalytic short-range activation in conjunction with long-range ("lateral") inhibition is capable of generating striking concentration patterns starting from near-uniform distributions. No features unusual in molecular biology are required, and self-regulatory properties observed experimentally in biological development can be accounted for. Cell responses to morphogenetic fields can include cell differentiation and the generation of bending moments, curvature and form in cell sheets giving rise to defined forms in organs and organisms. It appears that biological pattern formation is explicable on the basis of known physical laws and processes.
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002468:Cell Physiological Phenomena; D002477:Cells / Q000648:ultrastructure; D005796:Genes; D008954:Models, Biological
vernacular_title: Physik der biologischen Gestaltbildung.