title: Probenecid and intraocular methicillin.
abstract: Probenecid was given intravenously to rabbits in an effort to extend the intraocular longevity of intravitreal methicillin. With relatively high levels of probenecid, an insignificant elevation of half-life was obtained. Aqueous levels of methicillin were measured after intravitreal injection and were found to be adequate to inhibit penicillinase-producing S. aureus for approximately 20 hours.
mesh_terms: D000818:Animals; D001082:Aqueous Humor / Q000032:analysis; D004357:Drug Synergism; D006207:Half-Life; D008712:Methicillin / Q000032:analysis / Q000378:metabolism*; D011339:Probenecid / Q000378:metabolism*; D011817:Rabbits; D013997:Time Factors; D014822:Vitreous Body / Q000032:analysis / Q000378:metabolism*
chemical_list: D011339:Probenecid; D008712:Methicillin