Glucose tolerance curves in genetically diabetic KK-CAy mice: the pharmacokinetic analysis for humping effect.
Pharmacokinetic analysis on glucose tolerance curves in genetically diabetic KK-CAy mice treated with hypoglycemics was investigated using an analog computer. The glucose tolerance curves in KK-CAy mice showed humping phenomena. They could not be simulated by a simple compartmental model, but might be fitted to the model containing the non-linear function. "Compartment-H" model was contrived by adding the H-factor between glucose and insulin compartments. All the glucose tolerance curves in the KK-CAy mice could be simulated reasonable by this model and some suggestions on the humping effect were obtained from the analysis of H-factor. The H-factor was observed to be influenced by adrenergic alpha-blocker. This pharmacokinetic approach was indicated to be useful for the pharmacological research.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003201:Computers; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000235:genetics; D005951:Glucose Tolerance Test; D007700:Kinetics; D008297:Male; D051379:Mice; D008954:Models, Biological
D001786:Blood Glucose