title: The action of morphine and naloxone on acid secretion by the rat isolated stomach.
abstract: The action of morphine and naloxone on acid secretion by the rat isolated stomach has been studied. Morphine (10(-7) to 10(-4) M) had no effect upon spontaneous acid secretion. Morphine (10(-6) M) did not modify the acid output in response to sub-maximal stimulation by pentagastrin, histamine, bethanechol or isoprenaline. Naloxone (10(-6) M) was without effect on the response to pentagastrin or histamine. Our results suggest that opiate receptors do not modify acid secretion in this preparation.
mesh_terms: D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D013270:Stomach / Q000187:drug effects*
chemical_list: D009270:Naloxone; D009020:Morphine; D006632:Histamine; D007545:Isoproterenol