title: AP tuning curves from normal and pathological human and guinea pig cochleas.
abstract: Measures of cochlear selectivity can be obtained from compound responses using tone-on-tone masking procedures [Dallos and Cheatham, J. Acoust. Soc. Am. 59, 591--597 (1976)]. For the normal guinea pig, cochlear fiber tuning is sharper by a factor of 1.8 than AP tuning curves using simultaneous masking (threshold criterion = 25% N1 amplitude reduction). Anesthesia does not appear to affect AP tuning. In pathological cochleas, AP tuning is broadened by a factor of 2--3, and differences between forward and simultaneous masking curves are reduced. Tuning changes can sometimes occur without threshold elevation. AP tuning curves were obtained from humans during transtympanic electrocochleography. For subjects with near normal thresholds, Q10dB values (simultaneous masking) are approximately 2.3 at 2 kHz, 3.6 at 4 kHz, and 4.7 at 8 kHz. Using the relationship between cochlear fiber tuning and AP tuning in the guinea pig, estimates of human cochlear fiber tuning are 4.2 at 2 kHz, 6.5 at 4 kHz, and 8.5 at 8 kHz. Patients with threshold elevations of more than 30 dB resulting from cochlear deafness have AP tuning curves less sharply tuned by a factor of 2--3.
mesh_terms: D000200:Action Potentials; D000818:Animals; D001309:Auditory Threshold / Q000502:physiology; D003051:Cochlea / Q000502:physiology* / Q000503:physiopathology; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000503:physiopathology*; D006801:Humans; D007759:Labyrinth Diseases / Q000503:physiopathology; D010470:Perceptual Masking / Q000502:physiology; D010897:Pitch Discrimination / Q000502:physiology*