LDL receptor studies in term and pre-term infants: Measurement of sterol synthesis in cord blood lymphocytes.
Low density lipoprotein (LDL) receptor activity was measured in lymphocytes from pre-term and term infants in order to elucidate if the hypercholesterolemia found in pre-term infants might be secondary to a block in cholesterol transport across the cell membrane, analogous to that seen in familial hypercholesterolemia (FH).  LDL receptor activity was found to be fully developed in pre-term infants and no different from that of term infants and of a normal adult control.
D001692:Biological Transport; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D005865:Gestational Age; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000209:etiology; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D011955:Receptors, Drug / Q000378:metabolism*; D013261:Sterols / Q000096:biosynthesis*
D008077:Lipoproteins, LDL; D011955:Receptors, Drug; D013261:Sterols