title: Pharmacokinetic investigations of Craviten. IV. First-pass metabolism in rats.
abstract: Pharmacokinetic analysis of serum levels of Craviten found after oral and iv injection suggests, that the examined drug has a relatively low systemic availability. This lack of availability may be attributed to the metabolism of Craviten during the first passage into the circulation after oral administration.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000097:blood*; D005029:Ethylenediamines / Q000097:blood / Q000378:metabolism*; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D051381:Rats; D013997:Time Factors
chemical_list: D000889:Anti-Arrhythmia Agents; D005029:Ethylenediamines; C030706:butobendin