Effects of radiophosphorus on the developing endocrine glands of Swiss albino mice. II. The pituitary gland.
Effects of radiophosphorus, at the dose rate of 1.0 muCi/g body weight, was studied on the development of anterior pituitary in mice. P-32 injected to pregnant female 7 days after fertilization did not influence substantially the pituitary either of fetuses or younger borns. 1-day-old mice injected with P-32 reveal hypertrophy of acidophils. In mice injected at the 7th day, signs of cell death followed by an increase in the number of acidophils were found. Following injection of 14 and 21-day-old mice the decrease in the number of acidophils was very clearly visible. In 21 and 28-day-old injected groups, there is a difference in the reactivity of male and female pituitary to P-32. There may be individual variation in relation to radiation effects in pituitary, with advent of age.
D000367:Age Factors; D000818:Animals; D002470:Cell Survival; D005260:Female; D006984:Hypertrophy; D008297:Male; D051379:Mice; D010761:Phosphorus Radioisotopes; D010902:Pituitary Gland / Q000528:radiation effects*; D010903:Pituitary Gland, Anterior / Q000473:pathology / Q000528:radiation effects; D011829:Radiation Dosage; D012737:Sex Factors
D010761:Phosphorus Radioisotopes