Effects of aging on formalin-fixed brain weight in mice and rats.
In three mouse lineages it was found that during the 18- to 60-day interval after formalin fixation, brain weight was inversely proportional to the age at sacrifice, as was the decline in the weight of the brain during this period. In a second study using rat subjects it was confirmed that the aging difference is due to a reduction, in old age, of the swelling reaction of the brain when first placed in a formalin solution. It was suggested that this easily measured phenomenon might be employed as an operational index of brain aging.
D000375:Aging; D000818:Animals; D001921:Brain / Q000033:anatomy & histology* / Q000166:cytology; D005557:Formaldehyde; D051379:Mice; D009474:Neurons / Q000166:cytology; D009929:Organ Size; D051381:Rats; D014021:Tissue Preservation
D005557:Formaldehyde