title: [On the kinetics of pethidine in the late state of pregnancy (author's transl)].
abstract: The kinetic of pethidine (Dolcontral) during late pregnancy was investigated by means of an open two-compartment-model. The results were compared with a control group of nonpregnant women. Some pharmakokinetic parameters were found changed during gravidity, especially the distribution (V1, Vdss, Cpo, delta'), the elimination half-life and the biological half-life (t 1/2; ke1, t 1/2; beta). There was no significant difference in urin excretion of pethidin and norpethidin between both groups.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007700:Kinetics; D008614:Meperidine / Q000378:metabolism*; D008954:Models, Biological; D011247:Pregnancy; D011263:Pregnancy Trimester, Third
chemical_list: D008614:Meperidine
vernacular_title: Zur Kinetik von Pethidin in der Spätschwangerschaft.