Effect of histamine on E and EAC rosettes formation of normal and leukemic human lymphocytes.
Histamine at 10(-6) M inhibited E and increased EAC rosette formation of normal human peripheral lymphocytes. Cimetidine at 10(-3) M prevented the decrease in number of E rosette-forming cells. In CLL no influence of Hi on both E and EAC rosette formation was detected. In the light of these findings the presence of histamine receptor on human normal and leukemic lymphocytes is discussed.
D000328:Adult; D000368:Aged; D002927:Cimetidine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D007938:Leukemia / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011968:Receptors, Histamine / Q000502:physiology; D012397:Rosette Formation
D011968:Receptors, Histamine; D002927:Cimetidine; D006632:Histamine