[Trans-placental transfer of four anti-inflammatory agents. A study carried out by in vitro perfusion (author's transl)].
Phenylbutazone, oxyphenylbutazone, ketoprofene and indocid transfer through the placenta (TFp) were studied by perfusing a placental cotyledon at term in vitro. These drugs were used in the therapeutic doses that are employed in human clinical practice. Antipyrine was used as a control material to check the validity of the perfusion in each experiment. TFp of phenylbutazone was 25.83 per cent +/- 0.46, of oxyphenylbutazone 22.48 per cent +/- 1.38, of ketoprofene 35.574 per cent +/- 0.95 and of indomethacin 36.19 per cent +/- 0.26. The authors point out the advantages and the possible dangers of non-steroid anti-inflammatory agents used in pregnant women. They prefer the use of ketoprofene of indomethacin because the anti-prostaglandin properties of ketoprofene are greater although the TFp is significantly less.
D000893:Anti-Inflammatory Agents / Q000378:metabolism*; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000378:metabolism; D007660:Ketoprofen / Q000378:metabolism; D010113:Oxyphenbutazone / Q000378:metabolism; D010477:Perfusion; D010653:Phenylbutazone / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy
D000893:Anti-Inflammatory Agents; D007660:Ketoprofen; D010653:Phenylbutazone; D010113:Oxyphenbutazone; D007213:Indomethacin
Passage trans-placentaire de quatre anti-inflammatoires. Son étude par perfusion in vitro.