Severe penicillin-induced cholestasis in a 91-year-old woman.
An elderly woman was admitted for treatment of severe stasis ulceration, associated with varicose veins. One course of cloxacillin was given orally followed by a second course of penicillin-G to eradicate persistant hemolytic streptococcal skin infection. Deep progressive jaundice subsequently developed due to intrahepatic cholestasis and persisted for several weeks before resolution. Having excluded a progressive extrahepatic malignant lesion by appropriate investigations, the diagnosis was substantiated by classical changes present in a percutaneous liver biopsy.
D000208:Acute Disease; D000368:Aged; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D010068:Oxacillin / Q000009:adverse effects*; D010400:Penicillin G / Q000009:adverse effects*
D010400:Penicillin G; D010068:Oxacillin