Lymphocyte reactivity in Imuran-treated guinea-pigs and in vitro effect of colchicine.
Imuran treatment significantly diminished macrophage migration inhibition in immunized guinea-pigs and the percentage of E-rosette forming cells in all treated animals. 10(-6) M colchicine in vitro significantly increased the percentage of E-rosette forming cells in Imuran-treated animals. The results suggest possible alteration of the lymphocyte receptors after treatment with Imuran.
D000818:Animals; D001379:Azathioprine / Q000494:pharmacology*; D002464:Cell Migration Inhibition; D003078:Colchicine / Q000494:pharmacology*; D006168:Guinea Pigs; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D012397:Rosette Formation
D001379:Azathioprine; D003078:Colchicine