title: Acanthosis nigricans and the sign of Leser-Trélat associated with adenocarcinoma of the gallbladder.
abstract: A case of adenocarcinoma of the gallbladder associated with acanthosis nigricans and the sign of Leser-Trélat is presented. The significant underrepresentation of adenocarcinoma of the gallbladder in association with malignant acanthosis nigricans is noted. If malignant acanthosis nigricans is caused by an ectopic peptide, a relative lack of production of the postulated substance by gallbladder adenocarcinoma cells could account for this finding.
mesh_terms: D000052:Acanthosis Nigricans / Q000150:complications*; D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology; D005260:Female; D005706:Gallbladder Neoplasms / Q000150:complications* / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary; D008875:Middle Aged; D014860:Warts / Q000150:complications*