Adsorption of oral antidotes for acetaminophen poisoning (methionine and n-acetylcysteine) by activated charcoal.
An in vitro experiment was performed to assess the degree of adsorption of oral antidotes for acetaminophen poisoning, methionine and N-acetylcysteine, by activated charcoal. Results indicate that activated charcoal effectively adsorbs both methionine and N-acetylcysteine. Since these agents must be absorbed from the GI tract to prevent acetaminophen hepatotoxicity, concurrent administration of methionine or N-acetylcysteine and activated charcoal would be expected to markedly diminish their antidotal effectiveness.
D000082:Acetaminophen / Q000506:poisoning; D000111:Acetylcysteine; D000327:Adsorption; D000931:Antidotes; D002606:Charcoal; D055598:Chemical Phenomena; D002621:Chemistry; D008715:Methionine
D000931:Antidotes; D002606:Charcoal; D000082:Acetaminophen; D008715:Methionine; D000111:Acetylcysteine