[Glycosylated hemoglobin as an index of diabetes mellitus control (author's transl)].
Glycosylated hemoglobin ((HbA1c) is formed by structural modification of HbA in a slow and irreversible non-enzymatic reaction. Its concentration is proportional to mean blood glucose levels during approximately four weeks, being therefore a useful index of diabetes mellitus control. The introduction of a microcolumn chromatographic method that measures together the subfractions HbA1a + b + c (fast Hb) and is well correlated to HbA1c has permitted the routine clinical measurement of this parameter. The authors used this method to study the levels of glycosylated hemoglobin in normal subjects, acutely decompensated diabetics, and diabetic outpatients classified according to their degree of control. The highest levels were detected in acutely decompensated patients and in those with chronic poor compensation. It is concluded that HbA1 constitutes a good index of compensation in diabetes, and that it may in the future unify existing criteria on the disease, contributing to clarify the problems about the correlation between the degree of compensation of diabetes and the incidence and evolution of its specific complications.
D001786:Blood Glucose; D003920:Diabetes Mellitus / Q000097:blood* / Q000378:metabolism / Q000628:therapy; D006027:Glycosides / Q000378:metabolism; D006441:Hemoglobin A / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D012016:Reference Values
D001786:Blood Glucose; D006027:Glycosides; D006441:Hemoglobin A
Hemoglobina glucosilada como índice de control de la diabetes mellitus.