Biological properties of new acyl derivatives of tylosin.
The antibacterial activity of acyl derivatives of tylosin were examined in vitro and in vivo. The 4"-acyl group in the acylated tylosins enhanced the antibacterial activity and antimycoplasmal activity against some macrolide-resistant strains. The orally administered 3-acetyl-4" -isovaleryltylosin produced a higher blood level in mice and rabbits than tylosin and a good therapeutic effect on the infection of Staphylococcus aureus Smith in mice.
D000284:Administration, Oral; D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D007933:Leucomycins / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D009174:Mycoplasma / Q000187:drug effects; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus; D013329:Structure-Activity Relationship
D007933:Leucomycins