Angiography after temporary inhibition of blood flow followed by intraarterial 5-FU infusion in the treatment of liver metastases.
Temporary inhibition of the blood flow to the liver was performed in 20 patients with metastases by tightening slings around the hepatic artery for 16 hours. Infusion of 5-FU started two days later through a catheter in the gastroduodenal artery. The response to the treatment as revealed by angiography was swelling of the liver and necrosis of the metastases. Thirteen patients responded favourably to the treatment. Complications such as abscess formation, 5-FU leakage, thrombosis of the hepatic artery and development of aneurysm at the entry of the infusion catheter occurred in some patients.
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000627:therapeutic use*; D006499:Hepatic Artery / Q000000981:diagnostic imaging*; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000009:adverse effects; D008099:Liver / Q000473:pathology; D008102:Liver Circulation; D008113:Liver Neoplasms / Q000098:blood supply / Q000556:secondary* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011859:Radiography
D000970:Antineoplastic Agents; D005472:Fluorouracil