title: Continuous flow bead-bed dissolution apparatus for suppositories.
abstract: A bead-bed dissolution apparatus for suppositories was evaluated by measuring the release of benzocaine from various vehicles. During dissolution, suppositories soften, deform, disintegrate, and eventually pass through a phase change from a solid to an oil. The control of the interfacial area during dissolution is a key factor in obtaining experimentally reproducible release data. The proposed suppository dissolution apparatus was designed to provide greater constancy of the exposed suppository area for dissolution. The apparatus consisted of a glass bead-bed containing the suppository. A continuous flow of liquid was passed through the bead-bed at a constant rate. Direct contact of the suppository was maintained with the dissolution medium, confining the suppository within the beads.
mesh_terms: D001566:Benzocaine / Q000008:administration & dosage; D002626:Chemistry, Pharmaceutical / Q000295:instrumentation; D005079:Excipients; D012995:Solubility; D013488:Suppositories; D013678:Technology, Pharmaceutical; D013696:Temperature
chemical_list: D005079:Excipients; D013488:Suppositories; D001566:Benzocaine