title: [Energy allowance for antibody formation in rabbits immunized with cholera vaccine and by exposure to tetracyclines].
abstract: Oxidative phosphorylation and succinate dehydrogenase activity in liver mitochondria, as well as activity of glucoso-6-phosphate dehydrogenase in liver homogenates were studied on 126 rabbits immunized with cholera vaccine and exposed to tetracycline or doxycycline (vibramycin). It was found that tetracycline and especially doxycycline inhibited the bioenergy processes in both intact and immunized animals. The inhibitory effect of doxycycline was most pronounced in the immunized rabbits. The shifts in the titers of the specific antibodies under the experimental conditions directly correlated with the state of the endocellular oxidation-reduction processes.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000918:Antibody Specificity / Q000187:drug effects; D022121:Cholera Vaccines / Q000276:immunology*; D004734:Energy Metabolism; D007114:Immunization / Q000379:methods*; D008930:Mitochondria, Liver / Q000378:metabolism; D010085:Oxidative Phosphorylation; D011817:Rabbits; D013754:Tetracyclines / Q000276:immunology*; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D022121:Cholera Vaccines; D013754:Tetracyclines
vernacular_title: K voprosu ob énergeticheskom obespechenii antitelogeneza u krolikov pri immunizatsii kholernoĭ vaktsinoĭ i vozdeĭstvii tetratsiklinov.