title: Thiamine protection of murine L1210 leukemia cells against mechlorethamine cytotoxicity and its relation to the choline uptake system.
abstract: Thiamine is an inhibitor of choline transport by murine L1210 leukemia cells and a protector of these cells from growth inhibition by mechlorethamine in vitro. Combination chemotherapy of tumor bearing mice with thiamine and mechlorethamine increased the mechlorethamine dosage required for a 50 to 60 percent increase in survival time but did not improve survival over that obtained with mechlorethamine alone.
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002794:Choline / Q000378:metabolism* / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008466:Mechlorethamine / Q000037:antagonists & inhibitors*; D008558:Melphalan / Q000627:therapeutic use; D051379:Mice; D013831:Thiamine / Q000494:pharmacology*
chemical_list: D008466:Mechlorethamine; D002794:Choline; D008558:Melphalan; D013831:Thiamine