[Use of an express method in studying the cytotoxic action of antitumor antibiotics].
The cytostatic effect of some antitumor antibiotics such as carminomycin, olivomycin, bruneomycin, rubomycin C and adriamycin was studied with a rapid method based on measurement of 3H-thymidine and 14C-adenine incorporation into the tumor cells of suspended primary cultures of mouse lymphadenosis NK/Ly. The method is recommended for screening of antitumor antibiotics.
D000225:Adenine / Q000378:metabolism; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D002250:Carbon Radioisotopes; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical / Q000379:methods; D066298:In Vitro Techniques; D008223:Lymphoma / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D000903:Antibiotics, Antineoplastic; D002250:Carbon Radioisotopes; D014316:Tritium; D000225:Adenine; D013936:Thymidine
Ispol'zovanie ékspress-metoda pri izuchenii tsitotoksicheskogo deīstviia nekotorykh protivoopukholevykh antibiotikov.