title: Dissociation of reticuloendothelial cell and hepatocyte functions in alcoholic liver disease: a clinical study with a new Tc-99m-labeled hepatobiliary agent.
abstract: Tc-99m-sulfur colloid scintigrams were abnormal in four patients with hepatic dysfunction due to chronic alcohol abuse. Minimal uptake of radiocolloid in the liver suggested local reticuloendothelial (RE) cell failure. Imaging with a new hepatobiliary agent, Tc-99m-PIPIDA, revealed rapid hepatic accumulation and excretion of radiotracer with adequate visualization of the organ. Scintigraphic findings in these patients indicated a dissociation of hepatocyte and RE cell functions. Demonstration of adequate hepatocyte function with severe RE failure in alcoholic liver disease using a Tc-99m-labeled hepatobiliary agent has not been previously reported.
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007098:Imino Acids; D008099:Liver / Q000166:cytology / Q000000981:diagnostic imaging* / Q000473:pathology; D008104:Liver Cirrhosis, Alcoholic / Q000000981:diagnostic imaging*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D012157:Mononuclear Phagocyte System / Q000000981:diagnostic imaging* / Q000473:pathology; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D013154:Spleen / Q000000981:diagnostic imaging; D013455:Sulfur; D013667:Technetium; D013671:Technetium Tc 99m Sulfur Colloid; D014018:Tissue Distribution
chemical_list: D007098:Imino Acids; D015609:Organotechnetium Compounds; D013671:Technetium Tc 99m Sulfur Colloid; D013455:Sulfur; D013667:Technetium; C003693:technetium Tc 99m PIPIDA