Superoxide radical scavenging agents in treatment of alkali burns. An experimental study.
To test the hypothesis that superoxide radicals are involved in tissue destruction after alkali burns, superoxide dismutase, ascorbic acid, and glutathione were used as superoxide radical scavenging agents. Daily subconjunctival injections were given in rabbit eyes after alkali burns. Both superoxide dismutase and ascorbic acid were effective in preventing corneal perforations. Glutathione did not show any beneficial effect. These experiments suggest that superoxide radical scavenging agents may be useful in the treatment of ocular alkali burns.
D000468:Alkalies; D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use*; D002057:Burns, Chemical / Q000188:drug therapy*; D004195:Disease Models, Animal; D005126:Eye Burns / Q000139:chemically induced*; D005978:Glutathione / Q000627:therapeutic use; D011817:Rabbits; D013482:Superoxide Dismutase / Q000627:therapeutic use*
D000468:Alkalies; D013482:Superoxide Dismutase; D005978:Glutathione; D001205:Ascorbic Acid