title: The behaviour of tumour cells of ovarian carcinomata under in vitro conditions and the coincidence with clinical controllability of tumours.
abstract: The clinical significance of in vitro cytostatics testing, based on 96 patients with ovarian carcinomata over a 4-year period (1976-1979) is reported. Cell cultivation and short-time incubation are used for the purpose. The cytostatic effect are ascertained by microscopic comparative tests and determination of 3H-thymidine and -cytidine incorporation. The results obtained by in vitro methods coincide to about 70%. Ovarian carcinomata are most frequently sensitive to Adriblastin and least frequently to DTIC. The correlation rate between in vitro test results and clinical reality was 83%. The clinical significance of cytostatics testing in vitro consists in --the individualisation of the tumour chemotherapy, --the possibility of a prognostic estimate, --the ascertainment of causes of chemotherapy failure, --the prevention of useless therapeutic trials on the patient.
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D008938:Mitosis / Q000187:drug effects; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D011379:Prognosis
chemical_list: D000970:Antineoplastic Agents