Effects of resination on actions of anorexigenic agents.
The salt and resinated forms of three anorexigenic agents, d-amphetamine, d,1-amphetamine, and phentermine were examined in rats using two test systems. Appetite depression was determined using a deprivation-induced food consumption test and central stimulatory activity was measured by a two-lever continuous avoidance responding task. Dose-response and time-response studies indicated that the resinated forms of all three compounds had a delayed onset of action as anorexigenic agents and a reduced degree of central stimulatory activity as compared to the salt forms.
D000818:Animals; D001067:Appetite Depressants / Q000008:administration & dosage* / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D007475:Ion Exchange Resins; D008297:Male; D051381:Rats; D013997:Time Factors
D001067:Appetite Depressants; D003692:Delayed-Action Preparations; D007475:Ion Exchange Resins