Relative potency estimation for synthetic petroleum skin carcinogens.
A procedure for quantitative analysis of skin carcinogenesis data, for the purpose of establishing carcinogenic potency, has been applied to observations obtained from C3H mice exposed continuously to synthetic and natural petroleums. The importance of total polynuclear aromatic (PNA) content to the skin carcinogenic activity of the crude materials was also examined. Of three synthetic petroleums evaluated, all were shown capable of inducing skin neoplasms within a two-year exposure period. Under comparable exposure conditions a composite sample of five natural petroleums was noncarcinogenic. Comparison of the distributions of times to initial skin neoplasm versus dose rate, for groups exposed to synthetic fossil liquids and the reference skin carcinogen, benzo(a)pyrene, provided estimates of relative carcinotenic potency for the synthetic petroleums ranging from 1/500 to 1/1400 the potency of benzo(a)pyrene. The carcinogenic activity of a chemically isolated PNA fraction versus the crude from which it was derived suggested that this fraction was responsible for the carcinogenic activity of these synthetic petroleums in mouse skin.
D000818:Animals; D002273:Carcinogens; D005260:Female; D005648:Fuel Oils / Q000009:adverse effects / Q000633:toxicity; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010578:Petroleum / Q000009:adverse effects* / Q000633:toxicity; D012878:Skin Neoplasms / Q000139:chemically induced*
D002273:Carcinogens; D005648:Fuel Oils; D010578:Petroleum