Studies on the prevention of CCl4 induced liver necrosis by agents having effects on cell membrane.
Nupercaine, promazine and benadryl partially prevented liver injury produced by CCl4 given orally, 24 hours after administration, in contrast to cetyl trimethyl ammonium bromide and anthisan which did not show any effect. Only benadryl and anthisan were able to partially prevent liver damage at 24 hours caused by ip administration of CCl4. None of these compounds decreased CCl4 content in liver at 1; 3 or 6 hours after oral CCl4 administration. Results suggest that benadryl could prevent liver necrosis, changing the cell response to injury by CCl4.
D000284:Administration, Oral; D000818:Animals; D002251:Carbon Tetrachloride / Q000008:administration & dosage; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control*; D002462:Cell Membrane / Q000187:drug effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000517:prevention & control*; D007274:Injections, Intraperitoneal; D008297:Male; D009336:Necrosis / Q000517:prevention & control; D011817:Rabbits
D002251:Carbon Tetrachloride