Acetaldehyde penetrates the blood-liquor barrier of goats.
Goats received ethanol or acetaldehyde via carotid arterial infusions. Cerebrospinal fluid (CSF) was sampled for a lateral cerebral ventricle and blood from a jugular vein. Ethanol infusions produced only negligible levels of acetaldehyde in blood and CSF, but acetaldehyde infusions resulted in high levels. In contrast to ethanol, acetaldehyde was rapidly eliminated from both blood and CSF after discontinuing the infusion. The results indicate that even small amounts of acetaldehyde easily penetrate the blood-liquor barrier of goats.
D000079:Acetaldehyde / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D000431:Ethanol / Q000378:metabolism; D005260:Female; D006041:Goats
D000431:Ethanol; D000079:Acetaldehyde