[Thromboresistant properties of hydrophilic gels].
Hydrophilic gels were made using methyl methacrylate and N-vinylpyrrolidon. Simple designs of hydrophilic gels (films, tubes) for the in vitro studying of thromboresistant properties were manufactured. On the base of measurements of blood clotting time, concentration of prothrombin complex factors fibrinogen, heparin, thromboelastography, and thrombocyte adhesion onto hydrogel surface in blood contact; it was demonstrated that a hydrophilic gel consisting of 86 mol% of methyl methacrylate, 14 mol% of N-vinylpyrrolidon and 0.652 mol% of hydrolysed N-vinylpyrrolidon has optimum thromboresistant properties. Thromboresistant was studied in the dogs during 44 operations, in which both the aorta and peripheral vessels replaced by polypropylene prostheses or by Lavsan, modified by the addition of hydrophilic gels, were applied. It was shown that hydrophilic gels decrease thrombogenesis and promote rapid endothelialization and periprosthetic tissue vascularization.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001807:Blood Vessel Prosthesis / Q000009:adverse effects / Q000379:methods*; D004285:Dogs; D005343:Fibrinolytic Agents; D005782:Gels; D066298:In Vitro Techniques; D008768:Methylmethacrylates / Q000494:pharmacology*; D011205:Povidone / Q000494:pharmacology*; D013927:Thrombosis / Q000517:prevention & control*
D005343:Fibrinolytic Agents; D005782:Gels; D008768:Methylmethacrylates; D011205:Povidone
Tromborezistentnye svoĭstva gidrofil'nykh geleĭ.