Anti-nomifensine antibody causing immune hemolytic anemia and renal failure.
An anti-Nomifensine antibody was identified in a patient with immune hemolysis and renal failure who was under Nomifensine therapy. The anti-drug specificity of the antibody was confirmed by inhibition assays using Sepharose gel-Nomifensine conjugates. Preliminary screening tests for anti-Nomifensine antibody in a population of 104 patients treated by the drug showed no further example of such immunization.
D000372:Agglutination Tests; D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology*; D000906:Antibodies; D000917:Antibody Formation; D001667:Binding, Competitive; D003298:Coombs Test; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000276:immunology*; D007674:Kidney Diseases / Q000503:physiopathology*; D008875:Middle Aged; D009627:Nomifensine / Q000276:immunology*
D000906:Antibodies; D007546:Isoquinolines; D009627:Nomifensine