Probenecid and intraocular methicillin.
Probenecid was given intravenously to rabbits in an effort to extend the intraocular longevity of intravitreal methicillin. With relatively high levels of probenecid, an insignificant elevation of half-life was obtained. Aqueous levels of methicillin were measured after intravitreal injection and were found to be adequate to inhibit penicillinase-producing S. aureus for approximately 20 hours.
D000818:Animals; D001082:Aqueous Humor / Q000032:analysis; D004357:Drug Synergism; D006207:Half-Life; D008712:Methicillin / Q000032:analysis / Q000378:metabolism*; D011339:Probenecid / Q000378:metabolism*; D011817:Rabbits; D013997:Time Factors; D014822:Vitreous Body / Q000032:analysis / Q000378:metabolism*
D011339:Probenecid; D008712:Methicillin