title: Effect of reduced extracellular sodium concentration on the function of adrenal zona glomerulosa: studies on isolated glomerulosa cells from the rat.
abstract: Aldosterone production by isolated adrenal glomerulosa cells from the rat was estimated in the presence of varying concentrations of sodium ion. The reduction of sodium concentration by 5-20 mmol/l, with or without osmotic changes, did not influence the rate of aldosterone production. Aldosterone response to angiotensin II was not modified by varying the sodium concentration.
mesh_terms: D000311:Adrenal Glands / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D000450:Aldosterone / Q000096:biosynthesis*; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D005110:Extracellular Space / Q000378:metabolism; D005260:Female; D066298:In Vitro Techniques; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D012964:Sodium / Q000378:metabolism*
chemical_list: D000804:Angiotensin II; D000450:Aldosterone; D012964:Sodium