Metabolism of 1,3-dibromopropane.
Oral administration of 1,3-dibromopropane (2 mmol/kg) to rats resulted in a marked decrease in the level of hepatic glutathione (GSH). Sulphur-containing [14C]-metabolites were excreted in the bile of rats dose with 1,3-bromo[14C]propane and were subjected to enterohepatic cycling. After an oral dose of 1,3-dibromo[14C]propane, peak levels of radioactivity were rapidly attained in the blood and were maintained for several hours; approximately equal amounts of radioactive material were excreted in urine and expired air. Several radioactive metabolites were excreted in urine; a major metabolite was N-acetyl-S-[1-bromo-3-propyl]-cysteine.
D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D002250:Carbon Radioisotopes; D005978:Glutathione / Q000032:analysis; D006842:Hydrocarbons, Brominated / Q000378:metabolism; D008099:Liver / Q000032:analysis; D011407:Propane / Q000031:analogs & derivatives* / Q000378:metabolism; D051381:Rats
D002250:Carbon Radioisotopes; D006842:Hydrocarbons, Brominated; D005978:Glutathione; D011407:Propane; C032699:1,3-dibromopropane