Value of xenografts in the investigation of prostatic function: preliminary communication.
Two of 33 prostatic tumour xenografts were established and passaged. Testosterone supplementation did not improve tumour take rates. The histological grade of the parent tumour was the principal factor affecting xenograft survival. Preliminary studies on established tumour xenografts suggest that their value lies in the study of tumour biology, and that they have no direct therapeutic application at present.
D000818:Animals; D001119:Arginase / Q000378:metabolism; D003534:Cyproterone / Q000494:pharmacology; D004958:Estradiol / Q000097:blood / Q000494:pharmacology; D005260:Female; D006085:Graft Survival / Q000187:drug effects; D006801:Humans; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology; D011471:Prostatic Neoplasms / Q000097:blood / Q000201:enzymology / Q000473:pathology*; D013739:Testosterone / Q000097:blood / Q000494:pharmacology; D014183:Transplantation, Heterologous
D013739:Testosterone; D004958:Estradiol; D003534:Cyproterone; D001119:Arginase