title: Marek's disease as a model for the Landry--Guillain--Barré syndrome: latent viral infection in nonneuronal cells accompanied by specific immune responses to peripheral nerve and myelin.
abstract: In the chicken, Marek's disease virus (MDV) induces a demyelinating peripheral neuropathy that, early in the course of the disease, is histopathologically indistinguishable from that seen in the Landry--Guillain--Barré syndrome in man. A continuing role for a productive infection in the pathogenesis of this disease is unlikely, since neither MDV nor MDV antigens can be characteristically detected in nerves or spinal ganglia examined at necropsy. The authors investigated the possible role of a latent viral infection by explanting and maintaining in vitro the sciatic nerves and spinal ganglia from diseased birds. In these tissues, viral specific products were induced and detected by immunofluorescence and ultrastructural methods early after explanation in well-isolated Schwann cells, satellite cells, and lymphocytes. Later, virus was detected in fibroblasts, macrophages, and neoplastic lymphoblastoid cells. Neurons and myelinating Schwann cells, in contrast, did not replicate the agent. Specific cell-mediated and humoral immune responses to chicken peripheral nerve and peripheral nerve myelin were demonstrated early in the course of the disease. When considered relative to potential pathogenetic mechanisms, these results suggest that Marek's disease neuropathy is initiated by the establishment of a latent viral infection in neuronal supporting cells. A specific immune response to viral-induced antigens on these cells could, in turn, result in subsequent demyelination.
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D002478:Cells, Cultured; D002645:Chickens; D004195:Disease Models, Animal; D006564:Herpesviridae / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D008380:Marek Disease / Q000276:immunology*; D009185:Myelin Proteins / Q000276:immunology; D009924:Organ Culture Techniques; D010525:Peripheral Nerves / Q000276:immunology; D011129:Polyradiculoneuropathy / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D007074:Immunoglobulin G; D009185:Myelin Proteins