Recording of train-of-four evoked muscle responses from the nose and foreleg in the intact dog.
Evoked muscle responses to train-of-four electrical nerve stimuli were recorded from the nose and foreleg in the intact dog. Low and high doses of both suxamethonium and either pancuronium or gallamine were injected, and the recordings of muscle responses from each dog were examined. Recordings taken from the foreleg showed the presence of train-of-four fade until complete neuromuscular block was established. Simultaneous recordings from the nose showed the development of a train-of-four fade in early stages of neuromuscular block, but as the block increased, an unusual response developed where the twitch height became equal. This finding occurred following suxamethonium as well as non-depolarising relaxants.
D000818:Animals; D004285:Dogs; D004558:Electric Stimulation / Q000379:methods*; D005071:Evoked Potentials; D005154:Facial Nerve / Q000502:physiology; D005552:Forelimb / Q000502:physiology; D005703:Gallamine Triethiodide / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D009666:Nose / Q000502:physiology; D010197:Pancuronium / Q000494:pharmacology; D013390:Succinylcholine / Q000494:pharmacology; D014459:Ulnar Nerve / Q000502:physiology
D013390:Succinylcholine; D010197:Pancuronium; D005703:Gallamine Triethiodide