Biological profile of the steroid 5 alpha-stigmastane-3 beta, 5, 6 beta-triol-3-monobenzoate.
The steroid 5 alpha-stigmastane-3 beta, 5, 6 beta-triol-3-monobenzoate at a dose of 40 mg/kg/day showed significant antifertility activity when administered orally in a single or in consecutive doses during pre-implantation stage of pregnancy in mice. In the rabbit interceptive activity was obtained when the test steroid was administered on Day 8 of pregnancy in a single dose level. The compound failed to show any distinct estrogenic or androgenic property following bioassay method. But in McPhial test, the compound showed some progestagenic activity.
D000818:Animals; D003276:Contraceptives, Oral / Q000008:administration & dosage; D005260:Female; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D051379:Mice; D011374:Progesterone / Q000097:blood; D011817:Rabbits; D013261:Sterols / Q000008:administration & dosage / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects
D003276:Contraceptives, Oral; D013261:Sterols; C019091:5 alpha-stigmastane-3 beta,5,6 beta-triol 3-monobenzoate; D011374:Progesterone; D007986:Luteinizing Hormone