title: Lactic acidosis during metformin treatment in an elderly diabetic patient with impaired renal function.
abstract: In recent years, lactic acidosis has been described in association with metformin therapy in diabetics. We report a fatal case in an elderly diabetic patient with impaired renal function and cardiac insufficiency. The patient presented with an elevated plasma metformin concentration and a concomitant digitoxin intoxication.
mesh_terms: D000138:Acidosis / Q000139:chemically induced*; D000368:Aged; D003920:Diabetes Mellitus / Q000188:drug therapy*; D003928:Diabetic Nephropathies / Q000150:complications*; D004074:Digitoxin / Q000506:poisoning; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications; D007773:Lactates / Q000378:metabolism*; D008687:Metformin / Q000009:adverse effects*
chemical_list: D007773:Lactates; D008687:Metformin; D004074:Digitoxin