title: Prognostic significance of negative hysterectomy specimen following intracavitary irradiation in stage I endometrial carcinoma.
abstract: Clinical stage I endometrial carcinoma in 353 women was treated by pre-operative intracavitary irradiation with radium and total abdominal hysterectomy with bilateral salpingo-oophorectomy. No residual tumour was found in 36 per cent of uterine specimens obtained from hysterectomies performed within two weeks compared to 59 per cent of those removed later than eight weeks after the intracavitary irradiation. A negative hysterectomy specimen was a favourable prognostic index. Patients with no residual tumour in the hysterectomy specimens had a significantly lower five-years relapse rate (3.8 per cent) than those with residual tumour (19.2 per cent).
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy; D002584:Cervix Uteri / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D011379:Prognosis; D013997:Time Factors; D014594:Uterine Neoplasms / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery