Biochemical and immunological studies of lysosomal and related proteinases in health and disease.
A review of continuing studies on the physiological and pathological roles of the lysosomal proteinases, cathepsin D and cathepsin B is presented. Intracellular release of cathepsin D from lysosomes has been demonstrated during myocardial ischemia. Both this proteinase and cathepsin B have been found, by organ culture in the presence of the appropriate antiserum, to be released into the extracellular space in rheumatoid synovium, where they may play a part in cartilage destruction. Also reviewed is the finding of a cathepsin B-like proteinase that, in organ culture, is secreted in markedly increased amounts from human malignant breast carcinomas in comparison to amounts secreted from benign tumors or normal tissue.
D001172:Arthritis, Rheumatoid / Q000201:enzymology*; D001943:Breast Neoplasms / Q000201:enzymology*; D002356:Cartilage / Q000201:enzymology; D002401:Cathepsin B; D002402:Cathepsin D; D002403:Cathepsins / Q000378:metabolism* / Q000502:physiology; D006651:Histocytochemistry; D006801:Humans; D007120:Immunochemistry; D008247:Lysosomes / Q000201:enzymology*; D011509:Proteoglycans / Q000378:metabolism; D013583:Synovial Membrane / Q000201:enzymology
D011509:Proteoglycans; D002403:Cathepsins; D002401:Cathepsin B; D002402:Cathepsin D