Sensitivity to endogenous progesterone. Report of a case.
A patient with a cyclic premenstrual eruption, clearing spontaneously with the menstrual flow, is reported. Hypersensitivity to endogenous progesterone in this case was confirmed by positive intradermal and leukocyte migration inhibition tests. Treatment with conjugated estrogens was followed by remission of symptoms. The importance of awareness to the possibility of progesterone autoimmune mechanisms is emphasized.
D000328:Adult; D001327:Autoimmune Diseases / Q000503:physiopathology*; D002464:Cell Migration Inhibition; D005260:Female; D006801:Humans; D007962:Leukocytes; D008599:Menstruation Disturbances / Q000276:immunology*; D011374:Progesterone / Q000502:physiology*; D012871:Skin Diseases / Q000276:immunology*
D011374:Progesterone