[Production of a plasma substitute with hemodynamic properties based on modified globin of human erythrocytes].
The developed parameters for hemolyzate acid-base treatment in the presence of hydrogen peroxide with the subsequent ethanol fractionation made it possible to suggest a method for isolating a modified globin from erythrocytes of donor blood stored for different time. The method is of applied significance because it permits production not only of a new effective plasma substitute of the hemodynamic action but also contributes considerably to solution of the problem of the donor blood erythrocytes utilization.
D001782:Blood Donors; D001800:Blood Specimen Collection; D004912:Erythrocytes / Q000378:metabolism*; D005914:Globins / Q000302:isolation & purification*; D006439:Hemodynamics; D006801:Humans; D006861:Hydrogen Peroxide; D008722:Methods; D010952:Plasma Substitutes / Q000032:analysis*
D010952:Plasma Substitutes; D005914:Globins; D006861:Hydrogen Peroxide
Poluchenie plazmozamenitelia gemodinamicheskogo deistviia na osnove modifitsirovannogo globina epitrotsitov cheloveka.