[The effect of cimetidine on oxygen consumption and blood flow in the gastric fundus wall after dissection of the left gastric vessels: an experimental study on pigs (author's transl)].
Determination of the regional gastric blood flow in pigs with tracer microspheres indicates maximum blood flow in the fundus mucosa, even after dissection of the left gastric vessels. Excessive aerobic metabolism in this region was proved by measuring the arteriovenous oxygen difference. Fundus oxygen consumption was significantly depressed by cimetidine; change of blood flow distribution, a disadvantage for the seromuscular fundus layer, was inhibited.
D000818:Animals; D001794:Blood Pressure; D002927:Cimetidine / Q000494:pharmacology*; D004947:Esophagus / Q000601:surgery; D005748:Gastric Fundus / Q000098:blood supply; D005753:Gastric Mucosa / Q000098:blood supply*; D006146:Guanidines / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D011674:Pulse; D013552:Swine
D006146:Guanidines; D002927:Cimetidine
Der Einfluss von Cimetidin auf Sauerstoffverbrauch und Durchblutung des Magenfundus nach Ligatur der linken Magengefässe. Eine experimentelle Untersuchung am Hausschwein.