title: Immunological responses to training in conditioned runners.
abstract: 1. We measured the concentrations of leucocyte subpopulations, immunoglobulins and complement in six well-conditioned runners before and after a typical 8-mile (12.8 km) training run at 70-75% of VO2 max. 2. Before running all components were within the normal range. Exercise failed to produce a significant rise in neutrophils. There was also no change in immunoglobulins or complement concentrations immediately or 24 h after exercise. Lymphocyte subpopulations were also unchanged except for a progressive rise in antibody-dependent cytotoxic effector cells (K-lymphocytes). 3. These results suggest chronic exercise training has no apparent adverse effect on circulating cellular or humoral immune components in healthy subjects. An increase in K-lymphocytes may provide added host defence capacity during periods of stress, although the mechanism of increase is unexplained.
mesh_terms: D000328:Adult; D000920:Antibody-Dependent Cell Cytotoxicity; D003165:Complement System Proteins / Q000378:metabolism*; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism*; D007958:Leukocyte Count; D008297:Male; D005082:Physical Exertion; D010809:Physical Fitness; D012420:Running; D013178:Sports Medicine
chemical_list: D007136:Immunoglobulins; D003165:Complement System Proteins