Hormonal screening of hyperestrogenic, elderly, obese females for a granulosa cell tumor.
Two elderly, obese, postmenopausal patients demonstrated, for their age, inappropriate estrogen stimulation, elevated serum concentrations of estrone (E1) and estradiol (E2) and low serum concentrations of gonadotrophins. Hormonal evaluations before and after hysterectomy and bilateral salpingo-oophorectomy are reported. The first patient represents the eighth reported case of a granulosa cell tumor with documented preoperative and postoperative estrogen serum concentrations. Though the second patient had no evidence of an ovarian neoplasm, she demonstrates the complexity of attempting to preoperatively diagnose an early granulosa cell tumor in the elderly, obese female by hormonal profiles. The contribution of gonadotrophins and estrogens in making this diagnosis is discussed.
D000368:Aged; D000735:Androstenedione / Q000378:metabolism; D004967:Estrogens / Q000097:blood*; D005260:Female; D006065:Gonadotropins, Pituitary / Q000097:blood; D006106:Granulosa Cell Tumor / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D008593:Menopause; D009765:Obesity / Q000150:complications; D010051:Ovarian Neoplasms / Q000097:blood / Q000175:diagnosis*
D004967:Estrogens; D006065:Gonadotropins, Pituitary; D000735:Androstenedione