[Safety, antigenic activity, and epidemiologic effectiveness of live mumps vaccine from strain L-3. II. Antigenic activity and epidemiologic effectiveness].
The results obtained in the study of the antigenic activity and epidemiological effectiveness of live parotitis vaccine prepared from strain L-3 are presented. Children aged 3-7 years were shown to react to the injection of this preparation by the moderate production of virus-neutralizing antibodies (the percentage of persons with antibody titers of 1:8 and higher increased from 26.5 to 64.4). The most intensive antibody production was stimulated by the vaccines containing 40,000 and 20,000 viral particles in 1 vaccination dose. In seropositive children no significant shift in the antibody content was observed irrespective of the batch of the vaccine used. During 1 1/2 years of observation the morbidity rate of epidemic parotitis among children immunized with live parotitis vaccine was 6.9 times lower than among the unvaccinated children in the same groups and 8.8 times lower than among the children used as external control. The effectiveness rate of the vaccine was on the average 85.4% and 88.6%. The vaccines containing 40,000 and 20,000 HADU50 were found to have greater epidemiological effectiveness, while the epidemiological effectiveness of the vaccine containing 5,000 HADU50 was somewhat less. The effect of vaccination depended not only on the dose of the antigen and the initial state of the vaccines, but also on the extent of the coverage of children with vaccination in organized groups.
D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D006801:Humans; D009107:Mumps / Q000517:prevention & control*; D009108:Mumps Vaccine / Q000276:immunology*; D009500:Neutralization Tests; D013997:Time Factors; D014611:Vaccination
D000914:Antibodies, Viral; D009108:Mumps Vaccine
Bezvrednost', antigennaia aktivnost' i épidemiologicheskaia éffektivnost' zhivoi parotitnoĭ vaktsiny iz shtamma L-3. Soobshchenie II. Antigennaia aktivnost' i épidemiologicheskaia éffektivnost'.