Nucleotide sequence of human G gamma globin messenger RNA.
The nucleotide sequences of the entire coding portion and 3'-untranslated portion of the human G gamma globin mRNA have been determined by direct nucleotide sequence analysis of cloned human G gamma globin cDNAs. These nucleotides sequences have been compared to the previously published sequences of the human beta globin mRNA and A gamma globin mRNA. No differences were detected between the coding sequences of G gamma and A gamma globin mRNAs except for the expected difference at codon No. 136, but a number of differences were detected in the 3'-untranslated sequences of the two mRNAs. Codon usage of G gamma globin mRNA, although similar to that of the related beta globin mRNA, displays a few notable differences such as the use of UUG for leucine and GGA for glycine that are not utilized in beta globin mRNA.
D001483:Base Sequence; D002874:Chromosome Mapping; D004274:DNA, Recombinant / Q000032:analysis; D005796:Genes; D005914:Globins / Q000235:genetics*; D006801:Humans; D010957:Plasmids; D012333:RNA, Messenger; D014158:Transcription, Genetic
D004274:DNA, Recombinant; D012333:RNA, Messenger; D005914:Globins