Histologic stromal reaction of the host with gestational choriocarcinoma and its relation to clinical stage classification and prognosis.
One of the factors determining the prognosis of choriocarcinoma is the stromal reaction of the host. We have been interested in the histologic findings of this reaction, and we studied the relationship between the CPV classification, which had been used in our department, and our clinical stage. There was no relation of stage distribution to CPV classification. For instance, Type C, which has a strong stromal reaction, did not display any parallel relation with stage. When mortality rates and stages are compared, however, it is noteworthy that the mortality rate for Type C cases is small in Stage I and is less than 50% even in Stage III, in which metastasis is considered to be inevitable; thus, more than half of the cases are cured. On the contrary, Types P and C tend to be associated with high mortality rates even in Stages I and II, in which metastasis is not certain.
D002822:Choriocarcinoma / Q000473:pathology*; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology*; D011379:Prognosis; D014594:Uterine Neoplasms / Q000473:pathology*