Influence of oxotremorine on histamine level and histamine synthesis in the rat brain.
The i.p. administration of oxotremorine (2 mg/kg) produced a decrease of both formation of 14C-histamine and the activity of specific histamine-synthetizing enzyme--histidine decarboxylase (HD). Oxotremorine had no effect on histamine level in the brain when given alone, but lowered the amine content in L-histidine-treated rats. All of these effects of oxotremorine were antagonized by atropine sulphate, but not by atropine methyl nitrate--a cholinolytic drug which does not penetrate the blood-brain barrier. Presented findings indicate a possibility of ACh--HI interaction in the rat brain. Possible mechanism of oxotremorine action is discussed.
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects*; D002250:Carbon Radioisotopes; D005260:Female; D006632:Histamine / Q000032:analysis / Q000096:biosynthesis*; D006640:Histidine Decarboxylase / Q000032:analysis; D008297:Male; D010095:Oxotremorine / Q000494:pharmacology*; D051381:Rats
D002250:Carbon Radioisotopes; D010095:Oxotremorine; D001285:Atropine; D006632:Histamine; D006640:Histidine Decarboxylase; D000109:Acetylcholine