Experimental posterior subcapsular cataracts-with special reference to 1-beta-D-arabinofuranosyl-cytosine (Ara C)-induced cataracts.
Experimental posterior subcapsular cataracts were induced by the action of 1-beta-D-arabinofuranosyl-cytosine (ara C) and vincristine sulfate (VCR) in the rat crystalline lens. Differences between these two types of cataracts observed by light microscopy were degenerative necrosis of the anterior capsular epithelial cells (in the ara C-induced cataract), and the transdifferentiation phenomenon of the lens epithelial cells (VCR-induced cataract). Transformation of the epithelial cells and subsequent abnormal cellular differentiation (transdifferentiation) could be the primary trigger in he development of cataracts.
D000818:Animals; D002386:Cataract / Q000139:chemically induced* / Q000473:pathology; D002645:Chickens; D003561:Cytarabine; D007908:Lens, Crystalline / Q000473:pathology; D008297:Male; D008853:Microscopy; D051381:Rats; D014750:Vincristine
D003561:Cytarabine; D014750:Vincristine