Normal microbicidal function of monocytes in a girl with chronic granulomatous disease.
The history of a 13-year-old girl with a syndrome resembling Chronic Granulomatous Disease (C.G.D.) is described. Metabolic studies in granulocytes and monocytes classified the patient as having C.G.D. The granulocytes failed to kill Staphylococcus aureus and Candida Albicans; however, the killing of these microorganisms by the patient's monocytes was nearly normal. Family studies revealed no abnormalities in the phagocytic cells of the parents and the siblings.
D000293:Adolescent; D005260:Female; D006098:Granulocytes / Q000276:immunology; D006105:Granulomatous Disease, Chronic / Q000276:immunology*; D006801:Humans; D009000:Monocytes / Q000276:immunology / Q000502:physiology*; D010587:Phagocytosis