Evidence for the involvement of serotoninergic system in the male-induced ovo-implantation failure (Bruce effect) in mice.
Failure of ovo-implantation in newly mated female mice induced by exposure to alien males (Bruce effect) was prevented by administration of 2-(1-piperazinyl) quinoline maleate (quipazine). Since quipazine has serotonin receptor agonistic effect resulting in the elevation of prolactin secretion, it is suggested that the increased secretion of prolactin induced by the drug prevented the Bruce effect. The results suggest the involvement of the serotoninergic system in the sequence of events that leads to the Bruce effect.
D000818:Animals; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D011388:Prolactin / Q000032:analysis; D011814:Quipazine / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000502:physiology*; D013268:Stimulation, Chemical
D011985:Receptors, Serotonin; D012701:Serotonin; D011814:Quipazine; D011388:Prolactin