[Effect of a factor (factors) secreted by human amnion cells on the proliferative activity of normal and transformed fibroblasts].
The effect of FL-medium obtained upon cultivation of the human amniotic cells (FL) on the proliferative activity of intact (from spleen of C3H mice) and transformed (L-cells) fibroblasts was studied. The effect depended on the intensity of cell division: in case of high mitotic activity of fibroblasts in the control cultures FL-medium inhibited their proliferation and in case of low activity stimulated their division. It is suggested that the human amniotic cells secrete a factor (s) regulating the mitotic activity of cells in the culture medium.
D000650:Amnion / Q000378:metabolism; D000818:Animals; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000166:cytology*; D006801:Humans; D007739:L Cells; D051379:Mice; D008809:Mice, Inbred C3H; D008934:Mitogens / Q000378:metabolism; D008938:Mitosis; D014020:Tissue Extracts / Q000494:pharmacology*
D008934:Mitogens; D014020:Tissue Extracts
Vliianie faktora (faktorov), vydeliaemogo kletkami amniona cheloveka, na proliferativnuiu aktivnost' normal 'nykh i transformirovannykh fibroblastov.