Destruction of noradrenergic cell bodies by intracerebral 6-hydroxydopamine in the newborn rat.
Intracerebral injections of 6-hydroxydopamine directly in the nucleus locus coeruleus were performed in 4-day-old rats. The effects of such treatment on the subsequent development of this nucleus were analyzed and compared to those obtained in vehicle-injected age-paired controls. The 3 histological techniques used (Nissl, Glenner reaction, and histochemical fluorescence) indicated in the experimental group a progressive disappearance of the coerulean perikarya within 7 days postinjection. This lesion was permanent and did not induce any noradrenergic sprouting.
D000818:Animals; D000831:Animals, Newborn; D003714:Denervation; D006892:Hydroxydopamines / Q000494:pharmacology*; D008125:Locus Coeruleus / Q000187:drug effects*; D008856:Microscopy, Fluorescence; D009410:Nerve Degeneration / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats
D006892:Hydroxydopamines; D009638:Norepinephrine