[Estimation of the teratogenic effects of therapeutic drugs].
Therapeutics may induce embryological abnormalities in the laboratory animal, Now, it is known from experience that the currently applied experimental procedures allow to detect potential teratogenic risks in animals. There is only a slight possibility that a new therapeutic would be highly teratogenic as very special conditions are fundamental for the exteriorisation of the teratogenic effect, such as the sensibility and the developmental stage of the embryo, its genetic constitution and the physiology and pathology of the mother. The wellknown difficulties associated with the extrapolation of experimental results require that more species are used and that historical control data for each species and strains are kept allowing a global assessment of the results which better weighs the potential risk against the therapeutic activity of each new therapeutic.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D000830:Animals, Laboratory; D064420:Drug-Related Side Effects and Adverse Reactions
Beoordeling van teratogene nevenwerkingen van geneesmiddelen.