A new antibiotic K-82 A and minor components, produced by Streptomyces lavendulae, strain No. K-82.
From the results of taxonomic studies, Streptomyces sp. strain No. K-82 isolated from a soil sample collected in Kumamoto city, was identified as a strain belonging to Streptomyces lavendulae WAKSMAN & HENRICI 1948. The strain produced an active new antibiotic called K-82 A and minor components named the B complex. Antibiotic K-82 A was isolated as dark reddish needles by silica gel column chromatography and found to have both antibacterial activity and high phage induction activity. The K-82 B complex was found to consist of at least five components, among which K-82 B2 and B3 were isolated as crystals. Substances K-82 B2 was identified as benzoic acid from its physicochemical properties. Substance B3 like B2 had only marginal antibiotic activity.
D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001435:Bacteriophages / Q000254:growth & development; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003470:Culture Media / Q000032:analysis; D004352:Drug Resistance, Microbial; D005285:Fermentation; D013302:Streptomyces / Q000378:metabolism*; D013308:Streptonigrin / Q000494:pharmacology; D014775:Virus Activation / Q000187:drug effects
D000900:Anti-Bacterial Agents; D003470:Culture Media; D013308:Streptonigrin