Total and free serum haloperidol levels in schizophrenic patients and the effect of age thioridazine and fatty acid on haloperidol-serum protein binding in vitro.
1 Using radioimmunoassays, steady-state levels of total and free haloperidol (obtained by ultrafiltration and dialysis) have been determined in twenty-two patients on long term treatment receiving doses from 3 to 45 mg per day. 2 For the group, both total serum concentration and free drug concentration showed significant correlations (P less than 0.001) with daily dose. 3 No significant correlation was observed between age of the patient and percentage free haloperidol in serum. 4 In vitro experiments using sera from twenty-three healthy volunteers showed significant negative correlations (P less than 0.01) between age and percentage free haloperidol. 5 Thioridazine and oleic acid significantly enhanced the percentage of free haloperidol in normal human sera in vitro.
D000328:Adult; D000368:Aged; D000375:Aging; D004347:Drug Interactions; D005260:Female; D006220:Haloperidol / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009829:Oleic Acids / Q000494:pharmacology*; D011485:Protein Binding; D011863:Radioimmunoassay; D012559:Schizophrenia / Q000097:blood*; D013881:Thioridazine / Q000097:blood*
D009829:Oleic Acids; D006220:Haloperidol; D013881:Thioridazine