Identification of new urinary metabolites in man of quinine using methane chemical ionization gas chromatography-mass spectrometry.
1. Six new metabolites of quinine have been identified in urine of man by methane chemical ionization g.l.c.--mass spectrometry. 2. Metabolites identified were: unchanged quinine and dihydroquinine, 3-hydroxyquinine, 3-hydroxydihydroquinine, 6'-hydroxycinchonidine, 6'-hydroxydihydrocinchonidine, quinine-10,11-epoxide and quinine-10,11-dihydrodiol. 3. 10-Chloro-11-hydroxydihydroquinine was identified as an artifact of the isolation procedure. 4. Chloroquine and desethylchloroquine (artifacts) were identified in the urine, 17 days after completion of a 48 h treatment with chloroquine.
D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008697:Methane; D011802:Quinidine / Q000031:analogs & derivatives*; D011803:Quinine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000652:urine*
C013569:3-hydroxyquinidine; C029819:6'-hydroxycinchonidine; C029820:6'-hydroxydihydrocinchonidine; C029822:quinine-10,11-dihydrodiol; C029818:3-hydroxydihydroquinine; C029821:quinine-10,11-epoxide; C014486:hydroquinidine; D011803:Quinine; D011802:Quinidine; D008697:Methane