Mechanism of ossification. Calcium uptake by the bone organic matrix.
A protein in the bone matrix that retains calcium is described. This protein seems to start the ossification process. The reaction occurs in several steps from high energy phosphorylation to the formation of aggregates and calcium phosphate.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001031:Apatites / Q000378:metabolism; D001857:Bone Matrix / Q000378:metabolism*; D002113:Calcification, Physiologic; D002118:Calcium / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000494:pharmacology; D011817:Rabbits; D013696:Temperature
D001031:Apatites; D002135:Calcium-Binding Proteins; D000255:Adenosine Triphosphate; D008274:Magnesium; D002118:Calcium