A new and facile synthesis of purine 2'-amino-2'-deoxyribosides by a combination of chemical and enzymatic reactions.
An enzymatic synthesis of 2'-amino-2'-deoxy-2-chloroinosine and its chemical conversion to purine 2'-amino-2'-deoxyribosides are described. In addition, some of 2'-amino-2'-deoxy-ribosides of 6-substituted purine were also prepared from 2'-amino-2'-deoxyinosine.
D003853:Deoxyribonucleosides / Q000138:chemical synthesis*; D004885:Erwinia / Q000378:metabolism; D007202:Indicators and Reagents; D007288:Inosine / Q000031:analogs & derivatives / Q000138:chemical synthesis; D008722:Methods; D011684:Purine Nucleosides / Q000138:chemical synthesis; D013329:Structure-Activity Relationship
D003853:Deoxyribonucleosides; D007202:Indicators and Reagents; D011684:Purine Nucleosides; D007288:Inosine; C031079:2'-amino-2'deoxy-2-chloroinosine