Effects of 4-vinylcyclohexene and its main oxirane metabolite on mouse hepatic microsomal enzymes and glutathione levels.
When 4-vinylcyclohexene (VCHE) and 4-vinylcyclohexene monoxide (VCM) were administered to mice at 500 mg/kg, cytochrome P-450, cytochrome b5, NADPH-cytochrome c reductase and aminopyrine-N-demethylase and epoxide hydrolase were induced. Doses of 500 mg/kg of VCHE, VCM and 4-vinylcyclohexene diepoxide depleted rapidly hepatic reduced glutathione levels suggesting that glutathione is probably involved in the metabolism of VCHE.
D000818:Animals; D003510:Cyclohexanes / Q000009:adverse effects* / Q000378:metabolism; D053138:Cyclohexenes; D004790:Enzyme Induction; D004851:Epoxide Hydrolases / Q000096:biosynthesis; D005978:Glutathione / Q000032:analysis*; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology*; D014753:Vinyl Compounds
D003510:Cyclohexanes; D053138:Cyclohexenes; D014753:Vinyl Compounds; C013733:4-vinylcyclohexene; C030595:4-vinylcyclohexene monooxide; C012606:4-vinyl-1-cyclohexene dioxide; D004851:Epoxide Hydrolases; D005978:Glutathione