[Pregnancy and delivery following cardiac valve replacement (author's transl)].
We describe 30 patients with Starr-Edwards cardiac valve replacements who underwent pregnancy. Fourteen pregnant women who received anticoagulants gave rise to 3 neonatal anomalies such as congenital heart disease, polydactylia and microphthalmus. And fetal losses were 5 spontaneous abortions. Women with artificial valves can tolerate the hemodynamic load of pregnancy well, but there is an increased fetal wastage in patients taking oral anticoagulants (coumarin: warfarin). Namely, there is probably largely attributable to fetal hemorrhage but there is also a risk of malformation caused by teratogenic effects of warfarin. In contrast, pregnant women who didn't receive anticoagulants had the risk of thrombo-embolismus. It is suggested that the best plan is to use long acting oral anticoagulants during antenatal period and heparin over the periods of labor.
D000028:Abortion, Induced; D000022:Abortion, Spontaneous / Q000209:etiology; D000328:Adult; D036861:Delivery, Obstetric; D005260:Female; D006349:Heart Valve Diseases / Q000601:surgery; D006350:Heart Valve Prosthesis; D006801:Humans; D011184:Postoperative Period; D011225:Pre-Eclampsia / Q000209:etiology; D011247:Pregnancy