Oxidative degradation of 6-selenoguanosine in aqueous solutions.
The degradation of 6-selenoguanosine (NSC 137679) (I) in water and in various buffer systems was investigated. Drug degradation in aqueous media was monitored by high-pressure of I in various chromatography. Some kinetic aspects of the degradation of I in various buffer systems at 25 degrees also were studied spectrophotometrically. The degradation, which requires oxygen, involves autoxidation of I to the corresponding diselenide, which produces a selenide and metallic selenium in the presence of oxygen. This degradation pathway differs from that reported fro the oxidation of related thio compounds.
D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D006151:Guanosine / Q000031:analogs & derivatives*; D007700:Kinetics; D016566:Organoselenium Compounds; D010084:Oxidation-Reduction; D012643:Selenium; D012996:Solutions
D016566:Organoselenium Compounds; D012996:Solutions; D006151:Guanosine; C009228:6-selenoguanosine; D012643:Selenium