Effect gamma-melanotropin (gamma-MSH) on the conditioned behavior.
Effects of a dodecapeptide containing the gamma-MSH sequence on two types of conditioned behaviors were investigated. This peptide enhanced the avoidance response in poorly-performing mice, while it suppressed the self-stimulation lever pressing in rats. At higher doses, the peptide induced slight convulsions of a myoclonic type. The significance of these behavioral changes has not been assessed, but the results suggest that gamma-MSH may have some physiological function in the central nervous system.
D000595:Amino Acid Sequence; D000818:Animals; D003009:Clorazepate Dipotassium / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology*; D051381:Rats
D003009:Clorazepate Dipotassium; D009074:Melanocyte-Stimulating Hormones; D006220:Haloperidol