[The effect of phenobarbital on anti-mitotic activity of vincristine and colchicine. Experimental study].
The effect of phenobarbital on vincristine and colchicine antimitotic activity has been studied. The number of mitotic figures present in the rat bone marrow and Galeazzi-Lieberkühn cripts has been used to evaluate the overall proliferative activity of these cell populations. The administration of phenobarbital brought a reduction in the percentage of arrested mitoses in rat bone marrow and intestinal glands after treatment with vincristine and colchicine. Parallel studies on the phenobarbital effect on the LD50 and LD100 of vincristine and colchicine confirmed a decreased toxicity of these agents in the animals pretreated with phenobarbital.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D003078:Colchicine / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects*; D008297:Male; D008938:Mitosis / Q000187:drug effects*; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D014750:Vincristine / Q000494:pharmacology*
D014750:Vincristine; D003078:Colchicine; D010634:Phenobarbital
Effetto del fenobarbital sulla attività antimitotica della vincristina e della colchicina.