Familial hypo-alpha-lipoproteinemia.
A familial syndrome with hypo-alpha-lipoproteinemia is described. The affected propositus and his relatives have low levels of high density lipoprotein-cholesterol and apolipoprotein A, without any other lipid and lipoprotein abnormalities. Lipase activity and lecithin:cholesterol acyltransferase activity are also normal. A high prevalence of premature cardiac events was observed in this kindred, without any other established coronary risk factors present. The longevity analyses showed a shortening of life expectancy. The biochemical data and the pedigree are compatible with an autosomal dominant mode of inheritance.
D000328:Adult; D001053:Apolipoproteins / Q000097:blood; D005260:Female; D006801:Humans; D007009:Hypolipoproteinemias / Q000235:genetics*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D013631:Tangier Disease / Q000097:blood / Q000150:complications / Q000235:genetics*
D001053:Apolipoproteins; D008075:Lipoproteins, HDL