A genetic approach to the biosynthesis of the rifamycin-chromophore in Nocardia mediterranei. IV. Identification of 3-amino-5-hydroxybenzoic acid as a direct precursor of the seven-carbon amino starter-unit.
3-Amino-5-hydroxybenzoic acid was investigated for its ability to induce rifamycin biosynthesis in an appropriate mutant of Nocardia mediterranei and identified as a direct precursor of the seven-carbon amino starter-unit for the biosynthesis of ansamycins. A model for the biosynthesis of different types of ansamycins is presented and discussed.
D062365:Aminobenzoates / Q000138:chemical synthesis / Q000378:metabolism*; D001565:Benzoates / Q000378:metabolism; D062385:Hydroxybenzoates; D009154:Mutation; D009615:Nocardia / Q000235:genetics / Q000378:metabolism*; D012294:Rifamycins / Q000096:biosynthesis*
D062365:Aminobenzoates; D001565:Benzoates; D062385:Hydroxybenzoates; D012294:Rifamycins; C031509:3-amino-5-hydroxybenzoic acid