[Induction of sister chromatide exchange by trichloroethylene and its metabolites (author's transl)].
The mutagenecity of trichloroethylene and its metabolites (trichloroethanol and chloral hydrate) have been tested by using the method of sister chromatide exchanges (SCE). We have found the increasing SCE in workers chronically exposed to trichloroethylene. The increasing of SCE was also observed when the human lymphocytes were exposed to trichloroethanol and chloral hydrate in vitro in certain concentrations. The all results of tests groups are compared with those of the control groups and the difference is statistically significant.
D002697:Chloral Hydrate / Q000506:poisoning*; D002728:Chlorohydrins / Q000506:poisoning*; D003434:Crossing Over, Genetic; D005023:Ethylene Chlorohydrin / Q000031:analogs & derivatives / Q000506:poisoning*; D006801:Humans; D066298:In Vitro Techniques; D009152:Mutagenicity Tests; D009153:Mutagens / Q000506:poisoning*; D012854:Sister Chromatid Exchange; D014241:Trichloroethylene / Q000506:poisoning*
D002728:Chlorohydrins; D009153:Mutagens; D014241:Trichloroethylene; D002697:Chloral Hydrate; D005023:Ethylene Chlorohydrin; C005849:2,2,2-trichloroethanol
Induction d'échanges entre les chromatides soeurs (SCE) par le trichloréthylène et ses métabolites.