[Modification of the immune response by using an antigen bound to synthetic polyelectrolytes].
The immunogenic properties of the soluble complexes of bovine serum albumin (BSA) and synthetic polyelectrolytes were studied. The polyelectrolytes used in these complexes were 4-vinyl-N-ethylpyridinium bromide and 4-vinyl-N-cetylpyridinium bromide (complex I), 4-vinylpyridine and 4-vinyl-N-acetylpyridinium bromide (complex II). C57BL mice were immunized with different doses of BSA, complexes I and II introduced intraperitoneally in a single injection, and the number of plaque-forming cells (PFC) in the spleen was determined by modified Jerne's test with the use of BSA-covered sheep red blood cells. The above complexes were shown to stimulate the production of PFC against BSA 50-100 times more intensively than pure BSA. The mixtures of BSA with the above-mentioned polyelectrolytes stimulated PFC production to a considerably lesser extent. Thus, the polymeric part of these conjugates was not an antigen, but served as a carrier inducing pronounced immune response to the antigenic (protein) part of the complex.¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿
D000818:Animals; D002594:Cetylpyridinium / Q000031:analogs & derivatives / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology; D011145:Polyvinyls / Q000276:immunology*; D011485:Protein Binding; D011726:Pyridinium Compounds / Q000276:immunology*; D012710:Serum Albumin, Bovine / Q000276:immunology*
D011145:Polyvinyls; D011726:Pyridinium Compounds; C027968:poly-4-vinyl-N-ethylpyridine; D012710:Serum Albumin, Bovine; C029996:4-vinyl-N-cetylpyridinium; D002594:Cetylpyridinium
Modifikatsiia immunnogo otveta pri pomoshchi antigena, sviazannogo s neprirodnymi poliélektrolitami.