Acute postnatal regulation of pyruvate carboxylase activity by compartmentation of mitochondrial adenine nucleotides.
The total adenine nucleotide content of the mitochondrial matrix increases 3--4-fold within a few hours of birth in rat liver. This provides a mechanism for the acute postnatal regulation of pyruvate carboxylase, which is located in the matrix compartment and which requires ATP as a substrate. The sudden increase in pyruvate carboxylase activity is proposed to account for a rapid 4--5-fold increase in the gluconeogenic rate of the newborn rat.
D000227:Adenine Nucleotides / Q000378:metabolism*; D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D002451:Cell Compartmentation; D005260:Female; D008930:Mitochondria, Liver / Q000201:enzymology*; D011247:Pregnancy; D011766:Pyruvate Carboxylase / Q000378:metabolism*; D051381:Rats
D000227:Adenine Nucleotides; D011766:Pyruvate Carboxylase