Urinary bile acids in women treated with contraceptive steroids. A study using computerized gas chromatography-mass spectrometry.
Twenty-five different bile acids were determined by gas chromatography-mass spectrometry in 24 hour urine specimens before and during treatment with a commercial contraceptive drug. Neither excretion pattern nor individual amounts of bile acids showed any change during treatment of 4 healthy women. One woman with a history of recurrent cholestasis of pregnancy showed a slight increase in the levels of S-ALAT and total amount of urinary bile acids one day before she stopped taking the pill because of generalized itching. Another patient had a normal pattern of urinary bile acids after one year with a daily intake of 10 mg of estradiol valerate.
D000328:Adult; D001647:Bile Acids and Salts / Q000652:urine*; D003201:Computers; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008111:Liver Function Tests; D008875:Middle Aged; D011374:Progesterone / Q000097:blood
D001647:Bile Acids and Salts; D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D011374:Progesterone