title: Chloramphenicol administration during brain development: impairment of avoidance learning in adulthood.
abstract: Rats treated with chloramphenicol from days 7 to 21 of intrauterine life (50 milligrams per kilogram per day, injected subcutaneously into the mothers) or in the first 3 days of extrauterine life (50 to 100 milligrams per kilogram per day) were trained for avoidance conditioning when 60 days old. The acquisition of the avoidance response was impaired to a highly significant degree in all the treated groups.
mesh_terms: D000375:Aging; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000196:embryology / Q000254:growth & development*; D002701:Chloramphenicol / Q000494:pharmacology*; D005260:Female; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D012737:Sex Factors
chemical_list: D002701:Chloramphenicol