[Model system for studying thrombocyte interaction with the reconstructed vascular wall].
A new model system is suggested which is a partial reconstruction of normal, locally and vastly injured vessel walls on the basis of fibrillar collagen grown cultures of endothelial cells. The kinetic curve of adhesion on collagen of gel-filtered human platelets reaches saturation within 40 min. During adhesion the shape of collagen bound platelets changes. Acetyl-salicylic acid and platelet free serum inhibit adhesion. Endothelial cells are nonadhesive to platelets; they do not affect the platelet adhesion to the intercellular areas covered with fibrillar collagen.
D000818:Animals; D001808:Blood Vessels / Q000502:physiology*; D002417:Cattle; D002478:Cells, Cultured; D003094:Collagen / Q000502:physiology; D004727:Endothelium / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008722:Methods; D008855:Microscopy, Electron, Scanning; D008955:Models, Cardiovascular; D010973:Platelet Adhesiveness
D003094:Collagen
Model'naia sistema dlia izucheniia vzaimodeĭstviia trombotsitov s rekonstruirovannoĭ sosudistoĭ stenkoĭ.