Regulation of diabetic serum growth factors for human vascular cells by the metabolic control of diabetes mellitus.
Serum factors from non-ketotic poorly controlled non-insulin-dependent diabetic patients stimulated growth and protein synthesis of human arterial smooth muscle cells and fibroblasts by 15-42%, compared to serum factors from well controlled diabetics. In contrast, the growth stimulating effect of pooled sera from well controlled diabetics did not differ from the effect of normal sera. Single sera from the same diabetics before and after improvement of the metabolic control stimulated cell growth to a similar degree as the respective pooled sera from different diabetic populations. As far as increased growth stimulation of vascular cells is related to increased angiopathic risk in diabetics, this metabolic regulation of growth factors supports the demand for a continuous optimal control of diabetic metabolism.
D002478:Cells, Cultured; D003920:Diabetes Mellitus / Q000097:blood* / Q000628:therapy; D003925:Diabetic Angiopathies / Q000503:physiopathology; D005347:Fibroblasts; D006133:Growth Substances / Q000097:blood*; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000166:cytology* / Q000503:physiopathology
D006133:Growth Substances