In vitro study of (2S, 2'S) N,N'-dimethyl-N, N'-bis [1(3', 4', 5'-trimethoxybenzoyloxy) butyl-2] ethylenediamine salts and their bioavailability.
The aim of this study was to improve the oral dosage form of the title compound. The study include base, dihydrochloride and dimaleate. In vitro study was carried out on rat intestine, in vivo on rats and rabbits. The low absorption of the M-71 salts has been shown in both in vitro and in vivo studies. To increase bioavailability in men the tablets or enteric coated tablets should be made according to the results of clinical trials.
D000284:Administration, Oral; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000378:metabolism*; D001682:Biological Availability; D005029:Ethylenediamines / Q000378:metabolism*; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D011817:Rabbits; D051381:Rats; D013607:Tablets; D013608:Tablets, Enteric-Coated
D000889:Anti-Arrhythmia Agents; D005029:Ethylenediamines; D013607:Tablets; D013608:Tablets, Enteric-Coated; C030706:butobendin