An evaluation of triprolidine and pseudoephedrine in the treatment of allergic rhinitis.
A double-blind, parallel, placebo-controlled study was performed to assess the efficacy of a combination drug product containing the antihistamine, triprolidine, and the sympathomimetic, pseudoephedrine, in the treatment of allergic rhinitis. Allergic rhinitis was defined on the basis of coexistent nasal congestion and an aggregate symptom complex score which exceeded a pre-established value. Pseudoephedrine and triprolidine were shown to make distinct and separate contributions to the treatment of allergic rhinitis defined in this manner.
D000403:Airway Resistance / Q000187:drug effects; D004311:Double-Blind Method; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004809:Ephedrine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D010919:Placebos; D011725:Pyridines / Q000627:therapeutic use*; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*; D014311:Triprolidine / Q000627:therapeutic use*
D010919:Placebos; D011725:Pyridines; D014311:Triprolidine; D004809:Ephedrine