S-antigen uveitis in primates. A new model for human disease.
Uveitis was induced rhesus monkeys immunized with purified retinal S-antigen. Focal retinal and subretinal infiltration, in addition to periphlebitic changes, were observed histologically. Immunized monkeys had similar cell-mediated in vitro immune responses to the S-antigen as do humans with posterior uveitis. Circulating immune complexes at the time of disease could not be detected. This primate model supports the notion that the S-antigen may play a role in human uveitis.
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology*; D004195:Disease Models, Animal; D007114:Immunization; D008253:Macaca mulatta; D012160:Retina / Q000276:immunology* / Q000473:pathology; D014605:Uveitis / Q000209:etiology / Q000276:immunology* / Q000473:pathology
D000954:Antigens, Surface