[Effect of bivalent cations and fusogenic factors on the interaction of liposomes with planar phospholipid bilayers].
Using liposomes containing amphotericin B as an ionophoric marker the influence of some factors on fusion of the liposomes with planar phospholipid membranes was studied. Such liposomes increase the planar bilayer conductance and this fact can serve as quantitative characteristic of membranes fusion. The dependence of planar membrane conductance on Ca2+ concentration and phosphatidyl serine contents in liposomes was determined. It is shown that fusogenic factors such as lysophosphatidyl choline, retinol and osmolysis promote the fusion of vesicules with planar bilayer.
D000666:Amphotericin B; D002118:Calcium; D002413:Cations, Divalent; D008051:Lipid Bilayers; D008081:Liposomes; D008566:Membranes / Q000502:physiology; D008954:Models, Biological; D008968:Molecular Conformation; D010718:Phosphatidylserines; D010743:Phospholipids
D002413:Cations, Divalent; D008051:Lipid Bilayers; D008081:Liposomes; D010718:Phosphatidylserines; D010743:Phospholipids; D000666:Amphotericin B; D002118:Calcium
Vliianie dvukhvalentnykh kationov i fuzogennykh faktorov na vzaimodeĭstvie liposoms ploskim fosfolipidnym bisloem.