Inhibition of the plasma cholinesterase variants by propranolol.
The inhibitory effect of (+/-) propranolol 1.69 x 10(-4)-1.69 x 10(-7) mol litre-1 on normal and atypical plasma cholinesterase variants was investigated. The atypical enzyme is less sensitive to inhibition by (+/-) propranolol or either of its enantiomorphs than the usual enzyme. Propranolol 8.45 x 10(-6) mol litre-1 was used as differential inhibitor of 643 plasma samples from individuals of known genotype. Although the measurement of propranolol inhibition alone is not always unambiguous for assigning a definite genotype to a given individual, the correlation of propranolol inhibition with fluoride inhibition gives clear differentiation of the E1uE1u and E1UE1f phenotypes as well as other phenotypes.
D002800:Cholinesterase Inhibitors; D002802:Cholinesterases / Q000097:blood / Q000235:genetics*; D003992:Dibucaine / Q000494:pharmacology; D005459:Fluorides / Q000494:pharmacology; D014644:Genetic Variation / Q000187:drug effects*; D005838:Genotype; D006801:Humans; D010641:Phenotype; D011433:Propranolol / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D011433:Propranolol; D002802:Cholinesterases; D003992:Dibucaine; D005459:Fluorides