Newborn diagnosis of abnormal hemoglobins from a large municipal hospital in Los Angeles.
Cord blood samples from 29,611 infants born in Los Angeles over a 71/2 year period were examined for hemoglobinopathies. Among 4,134 Black newborns, the frequency of sickle cell anemia (SS) was 0.3 per cent, of sickle cell trait (AS) 8 per cent, and of Hb-C trait (AC) 2 per cent. Of 17,781 Spanish surnamed (Mexican) newborns, 0.5 per cent had sickle cell trait, and 0.1 per cent had Hb-C trait. Of the 5,541 Caucasian infants, 0.7 per cent had sickle cell trait, and 0.15 per cent had Hb-C trait. Twenty-three Black children with major hemoglobinopathies included 16 with sickle cell anemia, two with hemoglobin C disease (CC), and five with SC disease.
D000755:Anemia, Sickle Cell / Q000175:diagnosis*; D002140:California; D019411:Clinical Laboratory Techniques; D005006:Ethnicity; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006773:Hospitals, Municipal; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis*; D011368:Professional-Family Relations
D006455:Hemoglobins, Abnormal