title: [Effect of isoptin and its combination with strophanthin on collateral coronary circulation and systemic hemodynamics in acute myocardial ischemia].
abstract: It was established in acute experiments on dogs with the anterior interventricular branch of the left coronary artery ligated in the middle third that isoptin increases essentially the blood flow and oxygen tension in the focus of acute myocardial ischemia, increases the cardiac stroke and minute volumes, and reduces the total peripheral vascular resistance. Strophanthin removes the favourable effect of isoptin on collateral coronary circulation and contractile myocardial activity and increases the total peripheral vascular resistance.
mesh_terms: D000208:Acute Disease; D000818:Animals; D003097:Collateral Circulation / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D013328:Strophanthins / Q000627:therapeutic use*; D014700:Verapamil / Q000627:therapeutic use*
chemical_list: D013328:Strophanthins; D014700:Verapamil
vernacular_title: Vliianie izoptina i ego kombinatsii so strofantinom na kollateral'noe koronarnoe krovoobrashchenie i sistemnuiu gemodinamiku pri ostroĭ ishemii miokarda.