[Estimation of Stuart factor using a synthetic substitute during oral anticoagulant treatment. Preliminary results (author's transl)].
The estimation of Stuart Factor (Factor X) with a new synthetic substrate S-2337, and the prothrombin time were compared in 91 patients treated with oral anticoagulants for more than one month. There was a good correlation between the two tests (r = 0.79 and 0.81 depending on the thromboplastin used). The results of out short study suggest a therapeutic zone between 20 p cent and 32 p cent of factor X but these values require confirmation. This method may constitute a progress in the laboratory supervision of treatment with coumarin derivatives for it permits better standardisation of the results and may easily be adapted to an autoanalyser.
D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use*; D005170:Factor X / Q000032:analysis*; D006801:Humans; D009842:Oligopeptides; D011517:Prothrombin Time
D000925:Anticoagulants; D009842:Oligopeptides; C031023:S 2337; D005170:Factor X
Dosage du facteur Stuart à l' aide d' un substrat synthétique au cours des traitements anticoagulants oraux. Résultats préliminaires.