Pulmonary fibrosis of low calcium diet fed guinea pigs induced by the administration of a soluble immune complex.
Feeding animals a low calcium diet leads to lymphangiectasis of peribronchial lymphatic vessels, sometimes followed by overflow of lymphatic fluid into the surrounding tissue. Adding a soluble immune complex (SIC) to the diet, the peculiar diffuse interstitial pneumonia and finally pulmonary fibrosis were noted. Small honey-combed structures and sometimes histologic accommodation of epithelial lining cells were observed. Sometimes accumulation of leucocytes within honey-combed structures was seen.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000008:administration & dosage*; D002136:Calcium, Dietary / Q000009:adverse effects*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D011658:Pulmonary Fibrosis / Q000473:pathology*
D000936:Antigen-Antibody Complex; D002136:Calcium, Dietary