A comparison of the in vivo metabolism of phenothiazine and promazine in the neonatal guinea pig.
The in vivo metabolism of promazine and phenothiazine was studied in neonatal guinea pigs aged 1-21 days. Urinary metabolites were estimated for both compounds; marked fluctuations with age were noted, some values being greater than those found for adult animals. Unconjugated phenol (C-oxidation products) levels were very low, although glucuronide excretion was always present; glucuronyl transferase activity did not appear to be limiting, and was present as early as 1 day after birth. Peak sulphoxide excretion showed no correlation with output of other metabolites, suggesting that S- and C-oxidation are not directly linked.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001711:Biotransformation; D005260:Female; D006168:Guinea Pigs; D010640:Phenothiazines / Q000378:metabolism*; D011395:Promazine / Q000378:metabolism*
D010640:Phenothiazines; C031637:phenothiazine; D011395:Promazine