Prazosin-induced vasodilatation of muscle blood vessels in human hypertension. Evidence from strain-gauge plethysmography. Part I.
The fall of blood pressure provoked in hypertensive men by a single oral dose of 1 mg of prazosin is associated with an increase of forearm muscle blood flow. This phenomenon may be demonstrated by a sequence of strain-gauge plethysmographic measurements, taken at regular intervals (5-10 minutes), before and during the action of the drug, lasting more than 2 hours.
D001794:Blood Pressure / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D009132:Muscles / Q000098:blood supply*; D010991:Plethysmography / Q000379:methods; D011224:Prazosin / Q000494:pharmacology*; D011799:Quinazolines / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects*
D011799:Quinazolines; D011224:Prazosin