title: [Methods used for the in vivo study of the mutagenic properties of chemical substances].
abstract: Since man is much more closely related to other mammals than to bacteria fungi, plants or Drosophila, information obtained from mammals have obviously a much greater relevance to man than those from lower animals. Only the intact mammal can be utilized to obtain information on pharmacokinetic aspects such as absorption, elimination, biotransformation both inside and outside the target cells. Most mammalian assay systems employed for routine screening of mutagenic action rely on the detection of chromosome breaks in bone marrow, testis or in the dominant lethal test. In conclusion, it can be stated that in all cases, on should be guided by the consideration that no genetic risk whatsoever is acceptable when the mutagenic compound presents no clear benefit or when an alternative is available. Is this not the case, risks must be carefully balanced against possible benefits of the application of the mutagenic agent in question.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002467:Cell Nucleus / Q000187:drug effects; D002869:Chromosome Aberrations / Q000139:chemically induced; D025063:Chromosome Disorders; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests / Q000379:methods*; D009153:Mutagens / Q000494:pharmacology; D009154:Mutation; D013094:Spermatozoa / Q000187:drug effects
chemical_list: D009153:Mutagens
vernacular_title: Méthodes utilisées pour l'étude in vivo des propriétés mutagéniques des substances chimiques.