[Effect of hydrazine sulfate on lipid composition in rat liver homogenates and plasma membranes].
Introduction of hydrazine-sulphate to experimental animals decreases the total content of lipids in homogenates, but in plasmatic membranes of the liver it increases. The composition of certain classes of neutral lipids under these conditions is also changed. In particular, the contents of cholesterol and its esters as well as of free fatty acids decrease in the homogenate. The amount of glycerides remains unchanged. In the plasmatic membranes under the effect of hydrazine-sulphate the contents of cholesterol and its esters lowers and, vice versa, those of free fatty acids and glycerides rise. The molar glycerides-to-phospholipids ratio in the homogenates is unchanged but in the plasmatic membranes it increases, whereas the molar cholesterol-to-phospholipids ratio in the homogenates as well as in plasmatic membranes decreases.
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D002788:Cholesterol Esters / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005989:Glycerides / Q000378:metabolism; D006834:Hydrazines / Q000494:pharmacology*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008563:Membrane Lipids / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D051381:Rats
D002788:Cholesterol Esters; D005230:Fatty Acids, Nonesterified; D005989:Glycerides; D006834:Hydrazines; D008563:Membrane Lipids; D010743:Phospholipids; C029424:hydrazine; D002784:Cholesterol
Vliianie gidrazin-syl'fata na sostav lipidov v gomogenate i plazmaticheskikh membranakh pecheni krys.