title: [Synergic action of the combination of fosfomycin and kanendomycin against gram-positive and gram-negative bacteria].
abstract: Association between kanendomycin, an aminoglycoside antibiotic with a high antibacterial activity, non susceptible to inactivating action of acetylating enzymes and fosfomycin, an antimicrobial drug active only on bacterial cells, and without toxicity in man, was studied by Authors. An evidence synergism of two examined drugs was found particularly against Proteus spp. and Pseudomonas aeruginosa. A discussion about mechanisms of action of fosfomycin and kanendomycin is referred by Authors to explain this synergism.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004338:Drug Combinations; D004357:Drug Synergism; D005578:Fosfomycin / Q000494:pharmacology*; D007612:Kanamycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013045:Species Specificity
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; C001495:bekanamycin; D005578:Fosfomycin; D007612:Kanamycin
vernacular_title: Azione sinergica dell'associazione fosfo-kanendomicina nei confronti di germi gram - positivi e gram - negativi.