Differential effects of electroconvulsive shock and antidepressant drugs on serotonin-2 receptors in rat brain.
The effects of chronic administration of electroconvulsive shock and antidepressant drugs on rat brain serotonin-2 (5-HT2) receptors were investigated. Electroconvulsive shock increases the density and antidepressant drugs decrease the density of 5-HT2 receptors labelled by [3H]spiperone.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D002540:Cerebral Cortex / Q000378:metabolism; D004597:Electroshock; D008297:Male; D051381:Rats; D011985:Receptors, Serotonin / Q000032:analysis / Q000187:drug effects; D013134:Spiperone / Q000378:metabolism
D000928:Antidepressive Agents; D011985:Receptors, Serotonin; D013134:Spiperone