title: [Determination of the criteria for selecting the optimal obsidan and hypothiazide treatment regimen in hypertension based on mathematical modelling data].
abstract: Criteria for the choice of drug dosage are established. In mild changes of pulmonary hemodynamics in patients with hypertensive disease, minimum doses of hypothiazide are recommended, while treatment should be conducted with obsidan, for the main part. In considerable attendant disorders of pulmonary hemodynamics the dose of hypothiazide should be proportionally increased, while the dose of obsidan is reduced.
mesh_terms: D000328:Adult; D004359:Drug Therapy, Combination; D006439:Hemodynamics; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage*; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008433:Mathematics; D008875:Middle Aged; D008955:Models, Cardiovascular; D011433:Propranolol / Q000008:administration & dosage*
chemical_list: D006852:Hydrochlorothiazide; D011433:Propranolol
vernacular_title: Opredeleneie kriteriev dlia vybora optimal'nogo rezhima lecheniia obzidanom i gipotiazidom bol'nykh gipertonicheskoĭ bolezn'iu po dannym matematicheskogo modelirovaniia.