Guanidinoacetate methyltransferase activity in growing male rats fed on a raw field bean (Vicia faba L.) diet.
A significant reduction (p less than 0.01) in both the rate of growth and liver protein was found in growing male rats fed ad libitum over a 5-week period on a diet containing raw field bean (Vicia faba L.) as the sole source of protein, as compared to casein-fed rats. The activity of the hepatic enzyme guanidinoacetate methyltransferase (EC 2.1.1.2) as well as the urinary output of total nitrogen and creatinine were also significantly increased (p less than 0.01) in the legume-fed rats. The addition of methionine to the legume diet did not improve the antinutritive effect caused by the raw field bean. The possible nature of these effects is discussed.
D000818:Animals; D001835:Body Weight; D004044:Dietary Proteins / Q000008:administration & dosage; D007887:Fabaceae / Q000009:adverse effects*; D006146:Guanidines / Q000378:metabolism; D050937:Guanidinoacetate N-Methyltransferase; D008099:Liver / Q000033:anatomy & histology / Q000201:enzymology*; D008297:Male; D008780:Methyltransferases / Q000378:metabolism*; D009929:Organ Size; D010946:Plants, Medicinal; D051381:Rats
D004044:Dietary Proteins; D006146:Guanidines; D008780:Methyltransferases; C494508:Gamt protein, rat; D050937:Guanidinoacetate N-Methyltransferase