title: Insulin receptors in human placenta in relation to fetal weight and gestational age.
abstract: Insulin receptors were studied in human placentas from 26 wk to term, according to fetal and placental weight. Insulin-binding studies were performed in purified membranes with monoiodoinsulin biologically active. We found a marked decrease in receptor number in placentas corresponding to small for gestational age infants (S.G.A.) in relation to preterm and full-term adequate for gestational age (A.G.A.). Maximal insulin binding in human placentas was reached before 26 wk of gestation.
mesh_terms: D001724:Birth Weight; D002462:Cell Membrane / Q000502:physiology; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D010920:Placenta / Q000502:physiology*; D011247:Pregnancy; D011972:Receptor, Insulin / Q000502:physiology*; D013696:Temperature; D013997:Time Factors
chemical_list: D011972:Receptor, Insulin