Elimination pattern and biodistribution of [14C]chlorferron in rats.
Administration of [14C]chlorferron in a single oral dose of 0.5 and 20 mg/kg body weight to female rats resulted in a urinary excretion of greater than 74% of the given dose during the first 24 h. Approx. 8% of the dose was eliminated in faeces within 7 days. 7 days after dosing, very low levels of [14C]chlorferron-derived residues were detected in all analyzed organs. These findings indicated that chlorferron was absorbed from the gastro-intestinal tract in appreciable quantities, but was rapidly excreted mainly via the urine with small amounts only in the faeces.
D000818:Animals; D001711:Biotransformation; D003374:Coumarins / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D005260:Female; D007408:Intestinal Absorption; D051381:Rats; D014018:Tissue Distribution; D014468:Umbelliferones
D003374:Coumarins; D014468:Umbelliferones; C305311:chlorferron