Decreased retention of fatty acid conjugated DDT metabolites in rats given injections of heparin, bile salts or lecithin.
Intravenous injections of solutions of heparin, bile salts or lecithin into rats previously intraperitoneally injected with 14C-DDT significantly removed fatty acid conjugated 14C-DDT metabolites retained in their livers and spleens. These 14C-DDT metabolites comprised greater than 90 percent of the radioactivity present in these organs 10 days after the animals were first injected with 14C-DDT. The conjugation of DDT metabolites to fatty acids thus appears to be a primary mechanism by which DDT is ultimately retained in animals and possibly humans. Heparin, bile salts or lecithin might be used as clearing agents for removing these conjugates.
D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology*; D003634:DDT / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D006493:Heparin / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008297:Male; D010713:Phosphatidylcholines / Q000494:pharmacology*; D051381:Rats; D013154:Spleen / Q000378:metabolism
D001647:Bile Acids and Salts; D005227:Fatty Acids; D010713:Phosphatidylcholines; D006493:Heparin; D003634:DDT