title: Inhibition of intestinal glucose absorption in several animal species by cytochalasins.
abstract: The effect of various cytochalasins on intestinal glucose absorption in several animals species was investigated in vitro. Glucose absorption in mouse jejunum was highly inhibited (68.1%) by cytochalasin E (25.0 micrograms/ml) within 30-min incubation and less extent in rat (48.9%), hamster (34.1%), frog (28.1%), guinea pig (27.5%), rabbit (24.3%) and turtle jejunum (22.7%). Among cytochalasins A, B, C, D and E, cytochalasin E was a most potent derivative that could inhibit glucose absorption by up to 55.5% at a concentration of only 5.0 micrograms/ml in mouse jejunum and its effect may possibly be related to the formation of mini villi and the intracellular vacuoles in the intestinal absorptive cells.
mesh_terms: D000818:Animals; D006224:Cricetinae; D003572:Cytochalasins / Q000494:pharmacology*; D003864:Depression, Chemical; D005947:Glucose / Q000378:metabolism*; D006168:Guinea Pigs; D007408:Intestinal Absorption / Q000187:drug effects*; D007700:Kinetics; D051379:Mice; D013045:Species Specificity
chemical_list: D003572:Cytochalasins; D005947:Glucose