A package of computer programs designed to simulate pharmacokinetic monitoring of drug therapy.
Three programs are presented which have been developed to simulate conditions encountered in the pharmacokinetic adjustment of dosage regimens. The programs include a drug with one-compartment kinetics, whose elimination is dependent on renal function (gentamicin), a drug with two-compartment kinetics (theophylline), and a drug whose elimination follows non-linear Michaelis-Menten kinetics (phenytoin). The programs may be used as an aid to instruction in clinical pharmacokinetics and to develop and test new methods of pharmacokinetic adjustment of dosage regimens.
D003201:Computers; D004334:Drug Administration Schedule; D004358:Drug Therapy; D005839:Gentamicins / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010672:Phenytoin / Q000378:metabolism; D013806:Theophylline / Q000378:metabolism
D005839:Gentamicins; D004364:Pharmaceutical Preparations; D010672:Phenytoin; D013806:Theophylline