Hypothermia produced in aged squirrel monkeys by central administration of taurine.
Accidental hypothermia and heatstroke are more common in aged populations. While peripheral factors are undoubtedly important to the high incidence of dysthermia in the aged, alterations in central temperature controls associated with aging may be primarily responsible. It has been shown that the sensitivity of the hypothalamus to neurotransmitters is changed in aged animals, and it may be that similar alterations in central temperature controls underlie the increased susceptibility to dysthermia. As a first step in testing this hypothesis the responsiveness of central temperature controls of aged squirrel monkeys to taurine, a putative inhibitory neurotransmitter or neuromodulator, was tested. Intracerebroventricular (i.c.v.) administration of this sulfonated amino acid (0.5-4.0 mg) produced dose-related hypothermia in squirrel monkeys over nine years of age in a thermoneutral environment (23 degrees C). Younger animals had significantly smaller hypothermias. In a hot environment (30 degree C) there were no significant differences between the temperature decreases of the two age groups after any dose. However, in a cold environment (17 degrees C), in which young animals developed slightly larger hypothermias than in the thermoneutral environment, core temperature of the aged squirrel monkeys dropped so rapidly in response to even the lowest dose that they had to be removed and warmed to prevent death by hypothermia. The temperature controls of the aged squirrel monkey appear to be extremely sensitive to taurine. The findings indicate that a rise in central taurine concentration in old primates can, in a cold environment, produce an effect very much like accidental hypothermia in aged man.
D000375:Aging; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D007035:Hypothermia / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D012453:Saimiri; D013654:Taurine / Q000494:pharmacology*
D013654:Taurine