Gentamicin-induced nephrotoxicity in mice: protection by loop diuretics.
Gentamicin, at doses of 50 or 100 mg/kg body wt administered daily to healthy male MF1 mice by i.p. injection for either 7 or 10 days caused proximal tubular cell damage shown both by the urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) and by electron microscopy. The tubular damage was maximal at 7 days. Concomitant administration of any of 3 diuretics-frusemide, bumetanide or piretanide at 5,0.5 and 1 mg/kg body wt/day respectively-resulted in less tubular damage than that caused by gentamicin alone. This finding of protection by diuretics contrasts with those of previous studies of combination gentamicin-diuretic therapy.
D000118:Acetylglucosaminidase / Q000378:metabolism / Q000652:urine; D002034:Bumetanide / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use*; D005665:Furosemide / Q000627:therapeutic use; D005839:Gentamicins / Q000633:toxicity*; D007668:Kidney / Q000201:enzymology; D007674:Kidney Diseases / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D007687:Kidney Tubules, Proximal / Q000648:ultrastructure; D013449:Sulfonamides / Q000627:therapeutic use
D004232:Diuretics; D005839:Gentamicins; D013449:Sulfonamides; D002034:Bumetanide; D005665:Furosemide; C015451:piretanide; D000118:Acetylglucosaminidase