title: Health concerns in uranium mining and milling.
abstract: Mortality of uranium miners from both lung cancer and other respiratory diseases is strongly dependent on exposure to radon daughters, cigarette smoking and height. Lung cancer among 15 different mining groups (uranium, iron, lead, zinc) was analyzed to determine what factors influence incidence and the induction-latent period. At low exposure or exposure rates, alpha radiation is more efficient in inducing lung cancer, producing an upward convex exposure-response curve. The induction-latent period is shortened by increased age at start of mining, by cigarette smoking and by high exposure rates. For a follow-up period of 20 to 25 years, the incidence increases with age at start of mining, with magnitude of exposure and with amount of cigarette smoking. Instead of extrapolating downward from high exposures to estimate risk at low levels, it is suggested that it might be more appropriate to use cancer rates associated with background radiation as the lowest point on the exposure-response curve. Although health risks are much greater in uranium mines than mills, there is some health risk in the mills from long-lived radioactive materials.
mesh_terms: D000367:Age Factors; D001827:Body Height; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology*; D008669:Metallurgy; D008906:Mining; D011886:Radon; D012907:Smoking; D013548:Sweden; D014481:United States; D014501:Uranium
chemical_list: D014501:Uranium; D011886:Radon