The effects of water deprivation and water loading during treatment with 1-deamino-8-D-arginine vasopressin in central diabetes insipidus in childhood.
Nine children aged 7 2/12 to 17 9/12 years with central diabetes insipidus were subjected to water deprivation and water loading during treatment with 1-deamino-8-D-arginine vasopressin (DDVAP). Urine output remained unchanged despite the large differences in water intake. Serum osmolarity was not significantly affected by water deprivation. However, there was a marked decrease in serum osmolarity during water loading. This not accompanied by any symptoms of haemodilution. Thus patients apparently tolerate large variations in fluid intake during therapy with DDVAP.
D000293:Adolescent; D001127:Arginine Vasopressin / Q000031:analogs & derivatives*; D002648:Child; D003894:Deamino Arginine Vasopressin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D014867:Water / Q000008:administration & dosage / Q000378:metabolism*; D014868:Water Deprivation
D014867:Water; D001127:Arginine Vasopressin; C025161:vasopressin, deamino-homo-Arg-; D003894:Deamino Arginine Vasopressin