[Aspects of glycosylation of plasma proteins in patients with diabetes mellitus].
In 24 diabetic patients with different degree of metabolic control, the nonenzimatic glucosylation of plasma proteins, expressed as nmol of 5-hydroxymethylfurfural (HMF) per mg of plasma protein, showed values which were higher than those found in 1 control subjects. In the diabetics, this phenomenon could not be correlated with basal glucose plasma levels, while a linear regression was found with total glucosylated hemoglobin. It is proposed that the non-enzimatic glucosylation of plasma proteins may represent an index of medium-term control of diabetes mellitus.
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis*; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D006441:Hemoglobin A / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose; D001798:Blood Proteins; D006441:Hemoglobin A
Aspetti della glicosilazione delle proteine plasmatiche in soggetti affetti da diabete mellito.