[The isoenzymes of the alkaline phosphatases and their cancerologic biochemistries prospects (author's transl)].
The isoenzymes of the alkaline phosphatases of hepatic, intestinal, bony or placental origin are membrane glycoproteins the glycanic copula of which contains neutral hexoses, hexosamines and sialic acid (except for intestinal isoenzyme). Although the glycanic structures do not play a fundamental part into the enzymatic activity, they may however modulate it. In cancerology several new forms of isoenzymes such as the Regan, Nagao and Kasahara enzymes have been described. It appears, in fact that a great number of variants are present among the cancer patients. They can be differentiated by means of their electrophoretic mobility or their reactivity towards various inhibitors. These abnormalities might be included within the larger scope of membrane glycoprotein troubles of the cancerous cell.
D000328:Adult; D000469:Alkaline Phosphatase / Q000032:analysis* / Q000037:antagonists & inhibitors; D002462:Cell Membrane / Q000201:enzymology; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D004586:Electrophoresis; D005260:Female; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D007527:Isoenzymes / Q000032:analysis* / Q000037:antagonists & inhibitors; D008297:Male; D009369:Neoplasms / Q000201:enzymology*; D011247:Pregnancy
D006023:Glycoproteins; D007527:Isoenzymes; D000469:Alkaline Phosphatase
Les isoenzymes des phosphatases alcalines et leurs perspectives en biochimie cancérologique.