title: Acute toxicity of methotrexate and cyclophosphamide in mice inoculated with malignant neoplasms.
abstract: The toxicity of methotrexate and cyclophosphamide determined by LD50 was depressed in the early period of development of sarcoma Sa-180. In the late period of development of Sa-180 and in mice with leukemia L-1210 the toxicity was higher than in healthy mice. The growth of transplantable neoplasms leads to cachexia, hypoproteinemia and dysproteinemia.
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D003520:Cyclophosphamide / Q000633:toxicity*; D005260:Female; D007939:Leukemia L1210 / Q000188:drug therapy; D008727:Methotrexate / Q000633:toxicity*; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000097:blood / Q000188:drug therapy*; D012510:Sarcoma 180 / Q000188:drug therapy
chemical_list: D001798:Blood Proteins; D003520:Cyclophosphamide; D008727:Methotrexate