[Effect of the qualitative protein composition on oxidative metabolism at high altitude].
Experiments were carried out on 30 white rats to study the effect of deficiency of three indispensable amino acids (lysine, methionine and threonine) on the activity of oxidative enzymes on the 14th day of the animals' stay in the mountains (3400 m above the sea level). The rats which received a qualitatively inadequate diet as regards protein showed an activation of glycolysis, leading to the accumulation of underoxidized products (lactic acid) and a decrease in the rate of aerobic oxidation of the substances at the expense of the increased permeability of the biological membranes and egress of mitochondrial enzymes (dehydrogenases of Krebs cycle and cytochromoxidase) into cytoplasm.
D000531:Altitude; D000818:Animals; D001921:Brain / Q000201:enzymology; D004044:Dietary Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D008099:Liver / Q000201:enzymology; D008297:Male; D009132:Muscles / Q000201:enzymology; D010084:Oxidation-Reduction / Q000187:drug effects; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D004044:Dietary Proteins; D010088:Oxidoreductases
Vliianie kachestvennogo sostava belka na okislitel'nyĭ metabolizm v usloviiakh vysokogor'ia.