title: [1,6-Disubstituted 3-methylquinoxalin-2(1H)-ones. Effect on acquisition and modification of a conditioned avoidance response in the rat].
abstract: Sixteen derivatives of 3-methylquinoxalin-2(1H)-one were prepared; they are variously substituted on position 6 (R = H, COCH3, OCH3, CF3) and bear on position 1 an aminoalkyl chain (dimethylaminoethyl, dimethylaminopropyl, N-methylpiperazinylpropyl and morpholinylethyl). Most of these compounds exhibit a high degree of deconditioning activity on rats; compound (X) is significantly more active than chlorpromazine in the tests used.
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D002746:Chlorpromazine / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
chemical_list: D011810:Quinoxalines; D002746:Chlorpromazine
vernacular_title: 3-Metilchinossalin-2(1H)-oni 1,6-disostituiti. Effetto sull'acquisizione e sulla modificazione di una risposta condizionata di "avoidance" nel ratto.