title: Synthesis of metabolic intermediates of diethylstilbestrol.
abstract: This report details the synthesis of 1) 3,4,4'-trihydroxy-alpha, alpha'-diethyl-trans-stilbene; 2) 3,4-bis-(p-hydroxyphenyl)-trans-3-hexenol; 3) 3,4-bis-(p-hydroxyphenyl)-2,4-cis,cis-hexadienol; 4) 3,4-bis-(3'-methoxy-4'-hydrophenyl)-trans-3-hexene; 5) 3,4-bis-(3',4'-dimethoxyphenyl)-trans-3-hexene. These compounds are suspected metabolites of diethylstilbestrol.
mesh_terms: D004028:Dienestrol / Q000031:analogs & derivatives / Q000138:chemical synthesis; D004054:Diethylstilbestrol / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D007536:Isomerism; D008722:Methods; D013329:Structure-Activity Relationship
chemical_list: C029980:3,4-bis(4-hydroxyphenyl)-2,4-hexadienol; C029983:3,4-bis(4-hydroxyphenyl)-3-hexenol; C029982:3,4,4'-trihydroxy-alpha,alpha'-diethylstilbene; D004054:Diethylstilbestrol; C029984:3,4-bis(3'-methoxy-4'-hydroxyphenyl)-3-hexene; C029981:3,4-bis(3',3'-dimethoxyphenyl)-3-hexene; D004028:Dienestrol