title: Effect of cyclophosphamide, hydrocortisone and levamisole on collagen-induced arthritis in rats.
abstract: The immune response of rats to type II collagen was modified by pretreating the rats with levamisole, hydrocortisone, or cyclophosphamide. Rats were observed for the development of collagen-induced arthritis and were bled serially for the determination of antibody levels to type II collagen. Levamisole had a slight but not significant potentiating effect with arthritis developing earlier, whereas hydrocortisone and cyclophosphamide significantly depressed the incidence of arthritis; cyclophosphamide also delayed its onset. Antibody levels measured by radioimmunoassay paralleled the clinical course of arthritis.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000941:Antigens / Q000097:blood; D001168:Arthritis / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy; D003094:Collagen / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology*; D007978:Levamisole / Q000494:pharmacology*; D051381:Rats
chemical_list: D000941:Antigens; D007978:Levamisole; D003520:Cyclophosphamide; D003094:Collagen; D006854:Hydrocortisone