title: 'Nephritic factor' may be an autoantibody to C3b or C4b.
abstract: We attempted to clarify the character of 'Nephritic Factor' in the alternative (NeFA) and classical pathways (NeFC) of the complement, using an agglutinating and a hemolytic activity assay. The results suggested a possibility that NeFA and NeFC were different in their ability but might appear at the same time in some cases, and that NeFA was anti-C3b autoantibody and NeFC anti-C4b autoantibody.
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D003178:Complement C3 Nephritic Factor / Q000276:immunology*; D003179:Complement C3b / Q000276:immunology*; D003181:Complement C4 / Q000276:immunology*; D003169:Complement Inactivator Proteins / Q000276:immunology*; D003170:Complement Pathway, Alternative; D003171:Complement Pathway, Classical; D006801:Humans
chemical_list: D001323:Autoantibodies; D003178:Complement C3 Nephritic Factor; D003181:Complement C4; D003169:Complement Inactivator Proteins; D003179:Complement C3b