Structural correlates of seizure behavior in the mongolian gerbil.
Hippocampi of seizure-sensitive and seizure-resistant Mongolian gerbils were examined in search of structural correlates of seizure behavior. In animals with well-established seizure histories, differences were found in both presynaptic and postsynaptic structures. Seizing animals had less dense dendritic spines, a greater proportion of mossy tuft area devoted to presynaptic vesicles, and a smaller proportion devoted to spines. The possible relationship of these findings to epilepsy is discussed.
D000818:Animals; D004195:Disease Models, Animal; D005849:Gerbillinae / Q000033:anatomy & histology* / Q000502:physiology; D006624:Hippocampus / Q000033:anatomy & histology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D012640:Seizures / Q000473:pathology / Q000503:physiopathology*