Liver affection correlated to low antibody titres against Yersinia enterocolitica. A statistical analysis.
I have previously suggested that Yersinia enterocolitica may cause a chronic liver affection. The aim of the present study has been to provide a statistical support for this hypothesis. During a one-year period, 62 consecutive patients admitted to our department, clinically presenting with conditions often associated with Y.ent. infection, were examined for Y.ent. antibody titre and serum concentrations of bilirubin and the enzymes ASAT, LD and AP. The statistical analysis showed that Y.ent. antibody titres (in range negative to 320) were significantly correlated (p = 0.01) to serum bilirubin concentrations. The microorganism Yersinia enterocolitica should hence be considered as possible aetiological agent in cases of hepatic affection.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D000907:Antibodies, Bacterial / Q000032:analysis*; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008107:Liver Diseases / Q000097:blood / Q000209:etiology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015009:Yersinia Infections / Q000097:blood / Q000276:immunology*
D000907:Antibodies, Bacterial; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase; D001663:Bilirubin