In vitro studies on the intestinal absorption of curcumin in rats.
When everted sacs of rat intestines were incubated with 50-750- micrograms of curcumin in 10 ml incubation medium, 30-80% of the added curcumin disappeared from the mucosal side. No curcumin was however detectable in the serosal fluid. Less than 3% of the added curcumin was found in the tissue at the highest concentration. In experiments with [3H[ curcumin, 5-6% of added radioactivity was found in the serosal side. TLC examination of the mucosal extract showed the presence of 2 compounds, 1 corresponding to curcumin and the other to a less polar, colourless compound. The serosal fluid had no curcumin but a compound whose RF was identical with the colourless compound present in the mucosal side. These experiments indicated that curcumin undergoes transformation during absorption from the intestine.
D000818:Animals; D001826:Body Fluids / Q000378:metabolism; D002396:Catechols / Q000378:metabolism*; D003474:Curcumin / Q000378:metabolism*; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism; D007553:Isotope Labeling; D008297:Male; D051381:Rats; D014316:Tritium
D002396:Catechols; D014316:Tritium; D003474:Curcumin