title: Sulfur--selenium studies in sheep. II. Effect of a dietary sulfur deficiency on selenium and sulfur metabolism in sheep fed varying levels of selenomethionine.
abstract: The effect of a sulfur deficiency on the metabolism of selenium and sulfur was investigated in eight merino wethers. The sheep were fed high-sulfur (2 g S/kg) or low-sulfur (0.5 g S/kg) diets for two periods of 35 days each, and received selenium as selenomethionine at dietary concentrations of 0.02, 0.06, 0.09 and 0.67 mg Se/kg. Sheep fed the low-sulfur diet had reduced feed intake, reduced nitrogen, sulfur and selenium balance, but elevated plasma and wool selenium concentrations. Selenium concentrations in organs and tissues of slaughtered animals paralleled the selenium intake of the animal, with the renal cortex containing the highest concentration and bone the lowest. The effect of the 0.5 g S/kg diet on feed intake is in contrast with the results from the previous experiment (White and Somers 1977) using 0.7 g S/kg. It is this difference in fed intake which was responsible for many of the effects on selenium metabolism observed in this experiment. Once the feed intake effects are accounted for, the implications for sulfur--selenium interactions remain as before, i.e. more selenium is incorporated into wool and plasma protein when dietary sulfur is limiting than when it is not.
mesh_terms: D000818:Animals; D002369:Castration; D005247:Feeding Behavior / Q000187:drug effects; D005979:Glutathione Peroxidase / Q000097:blood; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D012643:Selenium / Q000378:metabolism* / Q000494:pharmacology*; D012645:Selenomethionine / Q000494:pharmacology*; D012756:Sheep; D013455:Sulfur / Q000172:deficiency / Q000378:metabolism*; D014935:Wool / Q000032:analysis
chemical_list: D013455:Sulfur; D012645:Selenomethionine; D005979:Glutathione Peroxidase; D012643:Selenium; D009584:Nitrogen