The effect of duodenal infusion of bile on plasma VIP, GIP, and secretin and on duodenal bicarbonate secretion.
Nine healthy young male students were studied before, during, and after a 10-min period of duodenal infusion of 6 g dried cattle bile dissolved in 75 ml distilled water to iso-osmolarity and pH adjusted to pH 7.0. Plasma vasoactive intestinal polypeptide (VIP), gastric inhibitory polypeptide (GIP), and duodenal bicarbonate secretion increased significantly, whereas plasma secretin showed a late but not significant tendency to rise after the bile infusion.
D000328:Adult; D001639:Bicarbonates / Q000378:metabolism*; D001646:Bile / Q000378:metabolism*; D004386:Duodenum / Q000378:metabolism*; D005749:Gastric Inhibitory Polypeptide / Q000097:blood*; D005768:Gastrointestinal Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D012633:Secretin / Q000097:blood*; D014660:Vasoactive Intestinal Peptide / Q000097:blood*
D001639:Bicarbonates; D005768:Gastrointestinal Hormones; D012633:Secretin; D014660:Vasoactive Intestinal Peptide; D005749:Gastric Inhibitory Polypeptide