title: Inhibition by morphine and morphine-like drugs of nicotine-induced emesis in cats.
abstract: The effect of morphine, methadone and pethidine injected into the cerebral ventricle of the unanesthetized cat upon emesis produced by nicotine induced similarly was investigated. Morphine and morphine-like drugs depress or abolish the emetic effect of nicotine. The inhibitory effect of morphine, methadone and pethidine is observed after a transient emetic action of these drugs. The emetic and anti-emetic action of morphine, methadone and pethidine can perhaps be ascribed to an agonist/antagonist activity. Further, the possible site of inhibitory action of morphine and morphine-like drugs on the emesis produced by nicotine may be the area postrema of fourth ventricle.
mesh_terms: D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004639:Emetics; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D008614:Meperidine / Q000494:pharmacology; D008691:Methadone / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology*; D009538:Nicotine / Q000037:antagonists & inhibitors / Q000633:toxicity*; D014839:Vomiting / Q000139:chemically induced*
chemical_list: D004639:Emetics; D009538:Nicotine; D009020:Morphine; D008614:Meperidine; D008691:Methadone