Activation of blood coagulation during inhalation challenge tests.
Bronchial challenge tests were performed in 16 asthmatic subjects. Eight developed an immediate and eight a dual asthmatic response. In all patients serial blood samples were analysed for plasma recalcification time and Factor XII activation rate. In all instances a profound shortening of the recalcification time was found, but only in patients with a dual response could an increased activation rate of Factor XII be detected. A positive correlation, although weak, was found between the time of maximum shortening of recalcification time and the time of onset of the late reaction. The study suggests a relationship between activation of blood coagulation factors and the type of asthmatic response elicited after challenge test.
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000097:blood*; D001777:Blood Coagulation; D001985:Bronchial Provocation Tests; D005174:Factor XII / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male
D005174:Factor XII