Effects of dimethylnitrosamine on some actions of testosterone.
Using homogenates of mouse kidney and testes, the activities of the enzymes, beta-glucuronidase and beta-galactosidase, were studied as markers of androgen action. The results obtained differed between testes and kidney homogenates. Dimethylnitrosamine (DMN) may cause a competitive inhibition of the anabolic action of testosterone in kidney homogenates but this was not evident from the results obtained with testes homogenates.
D000818:Animals; D004128:Dimethylnitrosamine / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects; D008297:Male; D051379:Mice; D013737:Testis / Q000187:drug effects* / Q000201:enzymology; D013739:Testosterone / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D013739:Testosterone; D004128:Dimethylnitrosamine