[Intra-arterial antibiotic therapy in the management of chronic post-traumatic osteomyelitis of the extremities (experimental and clinical studies].
Authors examined the changes of antibiotic concentration in the inflammatory focus after administering Gentamycin and Cephalothin intravenously or intraarterially in case of experimentally induced osteomyelitis in the tibia of rabbit. Administering Gentamycin i. v. no therapeutic level could be measured, while Cephalothin showed a therapeutic level of antibiotic concentration just for a short period. When the same doses of these antibiotics were administered in the femoral artery, effective local antibiotic concentration could be detected for 3 hours. Authors' clinical studies also support these experimental results. Performing 43 i. a. treatments in 38 patients with osteomyelitis 39 was rated as effective.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002512:Cephalothin / Q000008:administration & dosage / Q000627:therapeutic use; D002908:Chronic Disease; D005121:Extremities; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D011183:Postoperative Complications; D011817:Rabbits
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002512:Cephalothin
Intraarterielle Antibiotikatherapie in der Behandlung der chronischen posttraumatischen Osteomyelitis der Extremitäten (Experimentelle und klinische Untersuchungen).