Aortic cholesterol esterase and other lysosomal enzyme activities in DOCA-salt, renal and spontaneous hypertension in the rat.
In spontaneously hypertensive rats, prolonged hypertension caused a decrease in aortic cholesterol esterase activity with N-acetyl-beta-D-glucosaminidase activity increased and acid phosphatase activity unchanged [3]. The present study was undertaken to compare these changes with those caused by other experimentally induced types of hypertension. Treatment with DOCA-salt for one month significantly elevated both aortic cholesterol esterase and acid phosphatase activities. In contrast, to spontaneous hypertension, venous changes were also observed. An intake of 1% NaCl ad libitum produced results similar to those with the DOCA-salt treatment, despite the fact that blood pressure did not increase. This suggested that humoral factors were the main cause of the elevated enzyme activities in DOCA-salt hypertension. In rats made hypertensive by unilateral renal arterial constriction with contralateral nephrectomy (one clip--one kidney hypertension) or without contralateral nephrectomy (one clip--two kidney hypertension), aortic cholesterol esterase activities were unchanged, while aortic N-acetyl-beta-D-glucosaminidase, and aortic and venous acid phosphatase activities were increased. These results show distinct differences in the response of lysosomal enzymes during the three hypertensive states.
D000118:Acetylglucosaminidase / Q000097:blood; D000135:Acid Phosphatase / Q000097:blood; D000818:Animals; D001011:Aorta / Q000201:enzymology*; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D003900:Desoxycorticosterone; D006973:Hypertension / Q000139:chemically induced / Q000201:enzymology*; D006977:Hypertension, Renal / Q000201:enzymology; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D051381:Rats; D012965:Sodium Chloride; D002787:Sterol Esterase / Q000097:blood*
D003900:Desoxycorticosterone; D012965:Sodium Chloride; D002265:Carboxylic Ester Hydrolases; D002787:Sterol Esterase; D000135:Acid Phosphatase; D000118:Acetylglucosaminidase