Deglycyrrhizinised liquorice (DGL) and the renewal of rat stomach epithelium.
Deglycyrrhizinised liquorice (DGL) stimulated proliferation in the forestomach of the rat but did not stimulate and possibly even inhibited proliferation in the glandular part. DGL increased the number of fundus glands in which labelled mucus secreting cells occur as well as the total number of labelled mucus cells per gland. The mechanism of action proposed for DGL is that DGL stimulates and/or accelerates the differentiation to glandular cells as well as mucus formation and secretion. The accelerated proliferation observed in the forestomach is ascribed to an improved environment in the stomach as a consequence of the enhanced mucus secretion under the influence of DGL.
D000818:Animals; D004848:Epithelium / Q000187:drug effects; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006035:Glycyrrhiza; D008297:Male; D009093:Mucus / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical; D013936:Thymidine / Q000378:metabolism
D010936:Plant Extracts; C005981:deglycyrrhizinized liquorice; D013936:Thymidine