title: The interpretation of entropy/enthalpy compensation phenomena in the deacylation of acyl-alpha-chymotrypsins.
abstract: The thermodynamic-compensation law observed for the deacylation of a series of acyl-alpha-chymotrypsins has been re-examined. From consideration of the effect of small changes in delta delta H+(+)delta T along a homologous series, it is suggested that the high Tc value of 420 K observed for the process has its origin in the solvation of the acyl-group-catalyst transition state.
mesh_terms: D000215:Acylation; D002918:Chymotrypsin; D004789:Enzyme Activation / Q000187:drug effects; D006868:Hydrolysis; D008956:Models, Chemical; D009596:Nitrophenols; D012997:Solvents; D013816:Thermodynamics
chemical_list: D009596:Nitrophenols; D012997:Solvents; D002918:Chymotrypsin