title: [New possibilities to improve ileostomy-function by extremely high water-binding substances (author's transl)].
abstract: When an ileostoma is performed on rats, they usually die as a result of cachexia, which is caused by poor utilization of ingesta on account of rapid intestinal transit times. Assuming that oral administration of hydrophilic substances would prolong this transit and thereby the time of survival, rats with an ileostoma were fed a newly developed organic monomer. Its capacity to bind water is about 100 times its own weight. This substance was supplemented with standard diet of different concentrations. A much firmer fecal consistency resulted when 33% monomer was added to the diet. Animals fed a diet containing 50% monomer produced well-formed feces. There was no difference in survival time of the animals on a normal diet. furthermore, administration of a special hypercaloric diet did not cause a prolonged survival time. The reasons and possible therapeutic implications for patients with an ileostoma are discussed.
mesh_terms: D000818:Animals; D000930:Antidiarrheals / Q000627:therapeutic use*; D002100:Cachexia / Q000378:metabolism; D005243:Feces / Q000032:analysis; D005527:Food, Fortified; D007081:Ileostomy; D008297:Male; D009930:Organic Chemicals; D051381:Rats
chemical_list: D000930:Antidiarrheals; D009930:Organic Chemicals; C000599:Spenco Flakes
vernacular_title: Neue Möglichkeiten zur Verbesserung der Ileostomiefunktion durch extrem flüssigkeitsbindende Substanzen?