Left ventricular function after dynamic and static exercise in ischaemic heart disease.
The effects of dynamic and static exercise on left ventricular function in ischaemic heart disease were studied in 20 patients with angiographically documented coronary artery disease. Radiocardiography was used to determine left ventricular volumes at rest and during exercise tests. Dynamic exercise increased cardiac output significantly (p less than 0.001) in the 10 patients with one-vessel coronary artery disease, whereas end-diastolic and end-systolic volume and ejection fraction did not change from the resting values. In contrast, in the 10 patients with multiple coronary vessel disease significant increases in end-diastolic (p less than 0.05) and end-systolic volumes (p less than 0.001) were observed during dynamic exercise. Cardiac output increased by only 21% (p less than 0.05) while a decrease in ejection fraction (p less than 0.005) reflected pump dysfunction in these patients. Static exercise did not change cardiac output or end-diastolic volume significantly. The end-systolic volumes increased in both patient groups, more so in the patients with multi-vessel coronary involvement (p less than 0.005 and p less than 0.01, respectively). These data revealed a different left ventricular volume response to dynamic exercise in the patients with one-vessel coronary artery disease compared with those with multi-coronary involvement. The afterload stress taking place during the static exercise, on the other hand, evoked left ventricular dysfunction very sensitively and similarly, irrespective of the extent of coronary artery stenoses.
D000328:Adult; D003327:Coronary Disease / Q000503:physiopathology*; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D007537:Isometric Contraction; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D011877:Radionuclide Imaging