Effects of four bisphenolic antioxidants on prothrombin levels of rat plasma.
Male Sprague--Dawley rats were fed 2,2'-methylenebis(4-ethyl-6-tert-butylphenol), 2,2'-methylenebis(4-methyl-6-tert-butylphenol), 4,4'-butylidenebis(3-methyl-6-tert-butylphenol) or 4,4'-methylenebis(2,6-di-tert-butylphenol) at a level of 1.135 mmol/100 g in the diet for 1 week. The prothrombin and kaolin-partially thromboplastin time (PTT) indices were significantly decreased to 32% and 37% of control values in rats given 2,2'-methylenebis(4-methyl-6-tert-butylphenol). A slight decrease in prothrombin index of rats given 4,4'-butylidenebis(3-methyl-6-tert-butylphenol) was also observed.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D006470:Hemorrhage / Q000139:chemically induced; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010636:Phenols / Q000494:pharmacology*; D011516:Prothrombin / Q000378:metabolism*; D051381:Rats
D000975:Antioxidants; D010636:Phenols; D011516:Prothrombin