title: [Factors that provoke strophanthin poisoning and its drug prevention].
abstract: The effect of various pathogenic factors and drugs on sensitivity to strophanthin and the possibility of pharmacoprophylaxis of toxicosis caused by this cardiotonic agent were studied in acute and chronic experiments on 375 cats. It is shown that impaired blood supply to the myocardium, toxic affection of the liver, sensitization with the cardiac antigen, and the effect of inflammation mediators, mineralocorticoids, and some antianginous agents reduce strophanthin tolerance. The altered sensitivity to strophanthin is successfully corrected with the beta-adrenoblocker alpheprol, hydrocortisone, analgin, dimedrol, and the anesthetic trimecaine.
mesh_terms: D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D005260:Female; D007114:Immunization; D008099:Liver / Q000187:drug effects; D008297:Male; D010587:Phagocytosis / Q000187:drug effects; D013328:Strophanthins / Q000506:poisoning*; D013997:Time Factors
chemical_list: D000931:Antidotes; D013328:Strophanthins
vernacular_title: Faktory, provotsiruiushchie intoksikatsiiu strofantinom i ee farmakoprofilaktika.