[Effect of ethionamide and sodium succinate on NADPH-dependent oxidaton in the liver].
A single administration of ethionamide (LD50) to guinea pigs causes an inhibition of p-hydroxylation and N-demethylation in the liver. Sodium succinate favours the activation and, when it is used for correction of the ethionamide toxic effect, it normalizes the above-mentioned processes.
D000818:Animals; D005000:Ethionamide / Q000494:pharmacology*; D006168:Guinea Pigs; D006900:Hydroxylation; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009249:NADP / Q000378:metabolism*; D010084:Oxidation-Reduction; D013386:Succinates / Q000494:pharmacology*
D013386:Succinates; D009249:NADP; D005000:Ethionamide
Vliianie zhtionamida i suktsinata natriia na (NADPH) zavisimoe okislenie v pechni.