[Effect of chemical destruction of hypothalamic monoaminergic terminals on function of the adrenal cortex, thyroid gland and enterochromaffin system].
In experiments on rats the influence of noradrenergic, dopaminergic terminal destruction after 6-hydroxydopamine intraventricular injection and of serotoninergic terminal damage following 5,6-hydroxytryptamine administration on the adrenal cortex, thyroid and enterochromaffin body function was studied under basal conditions and during cold stress. As a result of noradrenergic terminal destruction basal- and cold stress-induced functional activity of the adrenal cortex and enterochromaffin body augmented. After serotoninergic terminal damage stress-induced intensification of the functional activity of the endocrine glands mentioned was blocked. The thyroid gland function changed under the hypothalamic noradrenergic and serotoninergic terminal destruction. In the first case a cold-induced rise in the gland functional activity was blocked and in the second one a stress-provoked growth of the thyroid gland activity was rather more than in the control.
D000302:Adrenal Cortex / Q000503:physiopathology*; D000818:Animals; D002838:Chromaffin System / Q000502:physiology*; D003080:Cold Temperature / Q000009:adverse effects; D003891:Desipramine / Q000494:pharmacology; D004759:Enterochromaffin Cells / Q000502:physiology*; D006892:Hydroxydopamines / Q000494:pharmacology; D007031:Hypothalamus / Q000187:drug effects*; D008297:Male; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology; D013312:Stress, Physiological / Q000503:physiopathology; D013961:Thyroid Gland / Q000503:physiopathology*
D006892:Hydroxydopamines; D011941:Receptors, Adrenergic; D012701:Serotonin; D003891:Desipramine
Vliianie khimicheskogo razrusheniia monoaminergicheskikh terminaleĭ gipotalamusa na funktsiiu kory nadpochechnikov, shchitovidnoĭ zhelezy i énterokhromaffinnoĭ sistemy.