Significance of monospecific antisera in the diagnosis and prognosis of autoimmune haemolytic anaemias.
The significance of the monospecific antiglobulin test in the diagnosis and prognosis of autoimmune haemolytic anaemia (AIHA) was tested in 74 patients with AIHA and 59 patients with secondary AIHA. There were 48 female and 26 male patients. Idiopathic AIHA patients more often had two or more positive monospecific reactions in the direct antiglobulin test than secondary AIHA patients. Increased serum lactate dehydrogenase levels, indicating increased intravascular haemolysis, were found more frequently in patients with two or more positive monospecific antiglobulin tests. The number of thromboembolic complications and deaths correlated positively with the number of positive monospecific reactions in antiglobulin test. In particular, positive direct antiglobulin test with monospecific anti-IgA was often combined with severe AIHA.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000175:diagnosis* / Q000276:immunology / Q000401:mortality; D001323:Autoantibodies / Q000276:immunology; D003298:Coombs Test; D005260:Female; D006801:Humans; D007106:Immune Sera; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D001323:Autoantibodies; D007106:Immune Sera; D007770:L-Lactate Dehydrogenase