Carcinogenicity in mice of mutagenic compounds from a tryptophan pyrolyzate.
The compounds 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole and 3-amino-1-methyl-5H-pyrido[4,3-b]indole, which are potent mutagens in a tryptophan pyrolyzate, ar hepatic carcinogens when given orally to mice at concentrations of 200 parts per million in a pellet diet. Female mice showed higher susceptibilities to both compounds than male mice.
D000818:Animals; D002243:Carbolines / Q000494:pharmacology*; D002273:Carcinogens; D004353:Drug Evaluation, Preclinical; D005260:Female; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009153:Mutagens / Q000494:pharmacology*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D012737:Sex Factors
D002243:Carbolines; D002273:Carcinogens; D007211:Indoles; D009153:Mutagens; C019133:3-amino-1-methyl-5H-pyrido(4,3-b)indole; C019132:3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole