The pathophysiology of acute renal failure after chlorprothixene overdosage.
Renal failure after an overdose of chlorprothixene has been attributed to a direct nephrotoxic effect of the drug. We report a carefully investigated case. No evidence of specific nephrotoxicity was revealed and we suggest that the renal failure is due to ischaemia during a transitory syncope, a well known side-effect of chlorprothixene.
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000503:physiopathology; D000328:Adult; D002749:Chlorprothixene / Q000506:poisoning*; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008297:Male; D013406:Suicide, Attempted
D002749:Chlorprothixene