title: Approach to the irradiation of extensive cervical and upper thoracic spinal astrocytoma.
abstract: Intramedullary spinal cord tumors are relatively rare, especially to the extent presented in this report. A 31-year-old woman had been diagnosed as having in inoperable astrocytoma, grade I-II, involving the entire cervical spinal cord and two upper thoracic segments. After decompressive laminectomy, she was referred for a radical course of radiation therapy. An irradiation technique was devised which allowed treatment of a single cylindrical volume of tissue encompassing the known tumor. Field fractionation with undesirable gaps and/or excessive dose to overlying normal structures were avoided. To the cervical spinal cord she received 5590 cGy in 29 fractions over 42 days. By this schedule she received at the same time 4820 cGy to the medulla oblongata and 4880 cGy to the upper thoracic cord. Partial neurological improvement occurred at the end of the treatment. The treatment approach is discussed in the background of the literature data.
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006801:Humans; D007796:Laminectomy; D011879:Radiotherapy Dosage; D013120:Spinal Cord Neoplasms / Q000532:radiotherapy* / Q000601:surgery