title: Some novel pyrazolone derivatives as anti-inflammatory agents.
abstract: Synthesis of three series of compounds namely; 4-(phenazon-4-ylazo)-1-substituted thiocarbamoyl-3-methyl-5-pyrazolones (3-8), 4-(phenazon-4-ylazo)-1-substituted-3-methyl-5-pyrazolones (9-20) and 4-(phenazon-4-ylazo)-1-substituted-3,5-dimethylpyrazoles (21-31) was achieved. These compounds were subjected to anti-inflammatory investigation and it was found that compounds 9 and 10 exhibited a remarkable anti-inflammatory activity, of which the former was the most potent.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D006097:Granulation Tissue / Q000187:drug effects; D006854:Hydrocortisone / Q000494:pharmacology; D010653:Phenylbutazone / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D011720:Pyrazoles; D010653:Phenylbutazone; D006854:Hydrocortisone