Simultaneous exposure of Chinese hamsters to ethanol and cigarette smoke: cytogenetic aspects.
Chinese hamsters (Cricetulus griseus) were treated with ethanol, with cigarette smoke and with both. During the experimental period of 12 weeks a control group of animals (c) received water ad libitum, another water drinking group received a cigarette smoke treatment during the last 4 weeks (S). Another group received 20% (v/v) ethanol during the whole experimental period as the only liquid supply (E), and one group with the same ethanol treatment was simultaneously treated with cigarette smoke during the last 4 weeks of the experiment (ES). The investigation of bone marrow cells after 12 weeks with regard to chromosomal aberrations and sister chromatid exchanges revealed no effects. A high mitotic activity was found in the smoke treated groups.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity*; D012854:Sister Chromatid Exchange; D012907:Smoking
D000431:Ethanol