[Studies of the real state of antibiotic consumption at an university hospital. Study in the pediatric department (author's transl)].
Antibiotic use at the Department of Pediatrics, Teikyo University Hospital was studied from 1974 to 1978, during which period a marked change was observed in the antibiotic consumption of Japan on the whole. From the view point of net weight of antibiotics consumed, beta-lactam antibiotics have been increasing up to more than 90% of antibiotic consumption and then follow macrolides and aminoglycoside substances. Chloramphenicol which was once the top antibiotic prescribed, and tetracyclines which have not been our choice, both have become very minor antibiotics in our present prescription. More than 90% of oral antibiotics were prescribed for outpatients and more than 90% of injectable antibiotics were administered to outpatients. Concerning oral penicillins, major three were ACPC, ABPC and AMPC for these years and as to oral CEPs most of them was CEX. ABPC and the fixed combination of ABPC and penicillinase resistant penicillin, were the top choice among injectable penicillins and CEZ was the top among CEPs. Concerning aminoglycoside antibiotic SM and KM were preferred as antituberculosis drug, and GM and DKB as antipseudomonas drug which took the main role in place with CBPC and SBPC since 1976. The type of oral drug preferred by pediatricians for prescription was also investigated and dry syrup type was found to be the most important one for pediatrics use. In spite of a steady increase of our outpatients for these five years, there was observed a remarkable decrease in number of antibiotic prescriptions, namely from 8,223 in 1974 to 4,613 in 1978. The reason is esteemed due to our policy to restrict possibly the needless use of oral antibiotics.
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002701:Chloramphenicol; D004304:Dosage Forms; D004363:Drug Utilization; D006748:Hospital Departments; D006785:Hospitals, University; D010372:Pediatrics; D010406:Penicillins; D013754:Tetracyclines
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D004304:Dosage Forms; D010406:Penicillins; D013754:Tetracyclines; D002701:Chloramphenicol