Is there a correlation between hippocampal mossy fiber distribution and two-way avoidance performance in mice and rats?
The distribution of hippocampal mossy fiber terminals, visualized by means of Timm's silver sulfide stain, was determined morphometrically in a selected hippocampal region. Five inbred mouse strains and two rat strains were used, all of them characterized by genetically controlled differences in performing a two-way avoidance task (shuttle-box). Those rat and mouse strains known for low avoidance scores had significantly more mossy fiber terminals synapsing within or below the layer hippocampal pyramidal neurons.
D000818:Animals; D001362:Avoidance Learning; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity