title: The role of N-nitrosamine in carcinogenesis at the ureterocolic anastomosis.
abstract: Seven cases of colonic tumours occurring at the ureterocolic anastomosis (UCA) in patients diverted for benign disease are presented and comparisons made with existing literature. There appears to be a definite increase in the incidence of colonic malignancy in patients with this diversion. A theory of carcinogenesis involving bacterial activation of endogenously formed N-nitrosamine is suggested. Preliminary results of rectal urine analysis support this theory in that high concentrations of N-nitrosamine have been found mutagens demonstrated.
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology* / Q000652:urine; D000328:Adult; D000368:Aged; D003106:Colon / Q000601:surgery; D003110:Colonic Neoplasms / Q000209:etiology* / Q000652:urine; D006801:Humans; D007417:Intestinal Polyps / Q000209:etiology* / Q000652:urine; D008875:Middle Aged; D009602:Nitrosamines / Q000652:urine*; D014513:Ureter / Q000601:surgery; D014547:Urinary Diversion / Q000009:adverse effects*
chemical_list: D009602:Nitrosamines