Levels of gastrin-cholecystokinin-like immunoreactivity in the brains of genetically obese and non-obese rats.
Levels of gastrin-cholecystokinin-like immunoreactivity were measured in three brain regions (cortex, diencephalon, brainstem) and the pituitary gland in groups of genetically obese Zucker rats and their non-obese littermates. The obese animals had significantly increased body weights and significantly lowered brain weights. However, levels of gastrin-cholecystokinin-like immunoreactivity were not different between the two groups in any of the regions measured. These results contrast with a recent report [11] in which ob/ob mice were found to have decreased levels of cholecystokinin in their brains.
D000818:Animals; D001835:Body Weight; D001923:Brain Chemistry; D001933:Brain Stem / Q000032:analysis; D002540:Cerebral Cortex / Q000032:analysis; D002766:Cholecystokinin / Q000032:analysis*; D004027:Diencephalon / Q000032:analysis; D005755:Gastrins / Q000032:analysis*; D008297:Male; D009765:Obesity / Q000378:metabolism*; D009929:Organ Size; D010902:Pituitary Gland / Q000032:analysis; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D014018:Tissue Distribution
D005755:Gastrins; D002766:Cholecystokinin