title: Pharmacokinetics of gentamicin in patients undergoing continuous ambulatory peritoneal dialysis.
abstract: Teh pharmacokinetics of gentamicin were studied in seven chronic renal failure patients undergoing continuous ambulatory peritoneal dialysis. Patients received 100 mg of gentamicin in 2 liters of dialysate during an initial pass, and serum and dialysate samples were collected for gentamicin determination. Approximately 49% of the amount introduced into the peritoneal cavity was absorbed systemically during a 6-h cycle. Subsequent clearance of gentamicin from the serum occurred slowly with an elimination half-life of 36 h. Dialysis clearance of gentamicin during continuous ambulatory peritoneal dialysis was 2.94 ml/min.
mesh_terms: D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D005839:Gentamicins / Q000378:metabolism*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism; D007700:Kinetics; D008875:Middle Aged; D010530:Peritoneal Dialysis
chemical_list: D005839:Gentamicins