On the plasma protein binding of 16-acetyl-gitoxin.
The plasma protein binding of 16-acetyl-gitoxin (16-AG) was estimated in comparison with that of digoxin by the use of equilibrium dialysis, ultracentrifugation, and gel filtration techniques. Depending on temperature, the binding of 16-AG reached values between 81 and 90%. Calculations of the reaction enthalpy and entropy show that hydrophobic interaction results. The corresponding values of digoxin amount to 13 and 15%.
D000113:Acetyldigoxins / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism*; D002301:Cardiac Glycosides / Q000378:metabolism*; D004077:Digoxin / Q000031:analogs & derivatives*; D006801:Humans; D011485:Protein Binding; D013696:Temperature
D000113:Acetyldigoxins; D001798:Blood Proteins; D002301:Cardiac Glycosides; C025972:16-acetylgitoxin; D004077:Digoxin