Myxothiazol, a new antibiotic interfering with respiration.
Myxothiazol, a new antibiotic from the myxobacterium Myxococcus fulvus, inhibited the growth of many yeasts and fungi at concentrations between 0.01 and 3 micrograms/ml. It was generally inactive against bacteria. The inhibitory effect was cytostatic. With Candida albicans, Saccharomyces cerevisiae, and Mucor hiemalis, the growth inhibition was neutralized by glucose. Soon after being added to a cell suspension, the compound almost completely blocked oxygen consumption.
D000935:Antifungal Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology; D008689:Methacrylates; D010101:Oxygen Consumption / Q000187:drug effects*; D013844:Thiazoles / Q000494:pharmacology
D000935:Antifungal Agents; D008689:Methacrylates; D013844:Thiazoles; C030517:myxothiazol; D005947:Glucose