[Protective effect of cholestyramine in the hepatocarcinogenesis of the rat (author's transl)].
The influence of cholestyramine on hepatocarcinogenesis was investigated in the Wistar rat. After 14 weekly gastric instillation of 50 mg diethylnitrosamine/kg and simultaneous administration of diet supplement with 1.3% cholestyramine, half of the animals developed hepatic tumors. In contrast, nearly all the animals in the control group under similar experimental conditions, but without the cholestyramine supplement in their diet, developed hepatic tumors. The sequestration of bile acids and the reduction of the noxious lithocholic acid could be considered as an explanation for the modification of hepatic tumors induced by diethylnitrosamine in the Wistar rat.
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D002792:Cholestyramine Resin / Q000627:therapeutic use*; D004052:Diethylnitrosamine / Q000633:toxicity; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D009374:Neoplasms, Experimental / Q000517:prevention & control; D051381:Rats
D001647:Bile Acids and Salts; D002792:Cholestyramine Resin; D004052:Diethylnitrosamine
Die tumorhemmende Wirkung von Cholestyramin in der Hepatocarcinogenese. Eine Tierexperimentelle Beobachtung (Vorläufige Mitteilung).