title: A package of computer programs designed to simulate pharmacokinetic monitoring of drug therapy.
abstract: Three programs are presented which have been developed to simulate conditions encountered in the pharmacokinetic adjustment of dosage regimens. The programs include a drug with one-compartment kinetics, whose elimination is dependent on renal function (gentamicin), a drug with two-compartment kinetics (theophylline), and a drug whose elimination follows non-linear Michaelis-Menten kinetics (phenytoin). The programs may be used as an aid to instruction in clinical pharmacokinetics and to develop and test new methods of pharmacokinetic adjustment of dosage regimens.
mesh_terms: D003201:Computers; D004334:Drug Administration Schedule; D004358:Drug Therapy; D005839:Gentamicins / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010672:Phenytoin / Q000378:metabolism; D013806:Theophylline / Q000378:metabolism
chemical_list: D005839:Gentamicins; D004364:Pharmaceutical Preparations; D010672:Phenytoin; D013806:Theophylline