title: In-vitro activity of erythromycin against anaerobic microorganisms.
abstract: Minimum inhibitory concentrations of erythromycin were determined, in the absence of CO2, for 256 strains of anaerobic microorganisms recently isolated from clinical practice. Of 126 strains of Bacteroides fragilis, 93% were inhibited by 6 mg/L, or less, of erythromycin. Of the remaining 130 isolates, 92% were inhibited by 6 mg/L, or less, of erythromycin. These findings suggest that the majority of anaerobic microorganisms would be inhibited by the serum levels achieved by administering 1 g of erythromycin intravenously, every six hours.
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D001441:Bacteroides fragilis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004917:Erythromycin / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D004917:Erythromycin