Cryptococcal meningitis: treatment of three patients with miconazole.
Three patients with cryptococcal meningitis who were treated with miconazole are reported. All patients had previously received combination therapy with amphotericin B and flucytosine which was unsuccessful. All patients showed clinical improvement, and one obtained a mycological remission. Miconazole was well tolerated, and would appear to be a relatively non-toxic and effective drug in the treatment of cryptococcal meningitis which is refractory to conventional chemotherapy.
D000328:Adult; D003453:Cryptococcosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008581:Meningitis / Q000188:drug therapy*; D008825:Miconazole / Q000627:therapeutic use*
D007093:Imidazoles; D008825:Miconazole