title: The effect of suxamethonium on intraocular pressure.
abstract: A method is described of measuring the elevation of the intraocular pressure (IOP) caused by suxamethonium in patients in whom other factors which may cause a change in IOP are kept constant. Use of this method confirms that suxamethonium 1 mg/kg causes a statistically significant rise in IOP which lasts for 10 minutes. A rise in IOP which is not significantly different from this is caused by suxamethonium 2.5 mg/kg, suxamethonium 1 mg/kg immediately preceded by thiopentone 3 mg/kg and by suxamethonium 1 mg/kg, 3 minutes after tubocurarine 0.1 mg/kg.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D013390:Succinylcholine / Q000494:pharmacology*; D013874:Thiopental / Q000494:pharmacology; D013997:Time Factors; D014403:Tubocurarine / Q000494:pharmacology
chemical_list: D013390:Succinylcholine; D013874:Thiopental; D014403:Tubocurarine