Cytotoxicity and the effect of combined treatment with X-rays of an anticancer 1-nitro-9-aminoacridine derivative in L5178Y-R and L5178Y-S cells.
The response to nitracrine, 1-nitro-9-[3'(N,N-dimethyl)aminopropyl] aminoacridine, an anticancer agent, was examined in two strains of murine lymphoma L5178Y inversely cross-sensitive to X-rays and UV light. A marked difference was found in sensitivity to the drug between L5178Y-R and L5178Y-S strain (D0 values 2.1 and 13.9 ng/ml, 3 h, 37 degrees C); survival was related to the yield of chromatid aberrations. Enhanced sensitivity of L5178Y-R cells to nitracrine as well as to UV light and an antitumor platinum complex has been ascribed to the previously found defect in post-replication repair in these cells. Combined treatment with nitracrine and X-rays under oxic conditions gave additive effects in both L5178Y strains.
D000609:Aminoacridines / Q000627:therapeutic use*; D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002842:Chromatids / Q000473:pathology; D002875:Chromosomes; D008223:Lymphoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D009564:Nitracrine / Q000494:pharmacology / Q000627:therapeutic use*
D000609:Aminoacridines; D009564:Nitracrine