Resistance to Fasciola hepatica in rats and rabbits following implantation of adult flukes contained in diffusion chambers.
Resistance to Fasciola hepatica could be elicited in rats by implanting mature flukes subcutaneously or intraperitoneally in diffusion chambers. A similar resistance occurred even when the implants were removed two weeks before challenge. This excluded the possibility that the continuing presence of the sensitising flukes was necessary for the maintenance of resistance and also showed that the resistance could be elicited by only two weeks exposure to diffusible immunogens emanating from the flukes.
D000818:Animals; D005210:Fasciola hepatica / Q000276:immunology* / Q000502:physiology; D005211:Fascioliasis / Q000201:enzymology / Q000276:immunology*; D005969:Glutamate Dehydrogenase / Q000097:blood; D011817:Rabbits; D051381:Rats
D005969:Glutamate Dehydrogenase