title: Is it important to preserve the chordae tendinae and papillary muscles during mitral valve replacement?
abstract: To evaluate the importance of preserving chordae tendinae and papillary muscles to left ventricular function after mitral valve replacement, 12 dogs had Carpentier-Edwards or Björk-Shiley mitral valves inserted. Cardiopulmonary bypass, systemic hypothermia at 25 degrees C and cold cardioplegia were used. The period of anoxic arrest was 30 minutes. In six dogs, mitral valve replacement was performed after complete excision of the mitral valve. In the other six dogs the anterior leaflet was partially excised but all chordae tendinae and papillary muscles were left intact. Hemodynamic measurements, including left ventricular function following volume loading, were made preoperatively and postoperatively. Left ventricular angiograms were obtained postoperatively in all dogs. Preoperatively there was no significant difference in the left ventricular function curves in the two groups, but postoperatively the curves showed significant differences. In the group with preserved chordae tendinae, left ventricular function improved with volume loading to a left ventricular end-diastolic pressure of 20 mm Hg while in the group with divided chordae tendinae, function improved more slowly and ceased to improve after loading to an end-diastolic pressure of 15 mm Hg. The mean left ventricular ejection fraction following mitral valve replacement with preserved papillary muscles was 0.62 +/- 0.01 and with divided papillary muscles was 0.45 +/- 0.05 (P less than 0.05). The authors conclude that it is important to preserve chordae tendinae and papillary muscles when carrying out mitral valve replacement.
mesh_terms: D000818:Animals; D002815:Chordae Tendineae / Q000502:physiology / Q000601:surgery*; D004285:Dogs; D006334:Heart Function Tests; D006350:Heart Valve Prosthesis / Q000379:methods*; D006352:Heart Ventricles / Q000503:physiopathology; D008943:Mitral Valve / Q000601:surgery*; D008954:Models, Biological; D010210:Papillary Muscles / Q000502:physiology / Q000601:surgery*