The effect of a parietal cell vagotomy and truncal vagotomy with and without drainage on duodenal ulcers in the rat.
The gastric secretagogues, pentagastrin and carbachol, produced a 100% incidence of duodenal ulcers. Truncal vagotomy (TV) and parietal cell vagotomy (PCV) prevented these experimental ulcers in the early post-operative period. At 3 weeks TV rats showed a decrease in weight gain, gross gastric distension and the infusion of gastric secretagogues now caused hypersecretory-induced gastric ulcers. TV and gastroenterostomy rats developed stomal ulceration and PCV failed to prevent formation of duodenal ulcers at 3 weeks. These results indicate that vagotomy, irrespective if truncal or highly selective, only has a temporary effect. This may be due to ischaemia or an altered sensitivity of the parietal cell mass with a post-operative recovery.
D000818:Animals; D002217:Carbachol / Q000009:adverse effects; D004322:Drainage; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D010418:Pentagastrin / Q000009:adverse effects; D011183:Postoperative Complications / Q000139:chemically induced; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced; D014628:Vagotomy / Q000379:methods*
D002217:Carbachol; D010418:Pentagastrin