Effects of inhaled asbestos, asbestos plus cigarette smoke, asbestos-cement and talc baby powder in hamsters.
Chronic exposure of hamsters to chrysotile asbestos resulted in severe asbestosis in all animals and in increased mortality; concomitant exposure to cigarette smoke did not affect type or severity of asbestotic lesions. Chronic exposure to asbestos-cement dust increased the number of macrophages and ferruginous bodies. Exposure to talc baby powder caused no significant changes. Deposition of talc particles in the lungs was demonstrated by X-ray fluorescence and X-ray diffraction and by a study with neutron-activated talc. No malignant tumours were observed in any of these studies.
D000818:Animals; D001194:Asbestos / Q000008:administration & dosage*; D001195:Asbestosis / Q000209:etiology*; D006224:Cricetinae; D001239:Inhalation; D008168:Lung / Q000032:analysis; D008647:Mesocricetus; D010947:Plants, Toxic; D012906:Smoke; D013627:Talc / Q000008:administration & dosage* / Q000032:analysis; D014026:Nicotiana
D012906:Smoke; D001194:Asbestos; D013627:Talc