Caffeine blocks the delayed K+ outward current of molluscan neurons.
Extracellular application of caffeine inhibits the delayed K+ outward current of Aplysia neurons in a dose dependent manner without changing the kinetics. Half-maximum blockade is produced with a concentration of 16.0 +/- 0.7 mM (S.E.M.) caffeine after 1-2 min. Intracellular injection of caffeine has an almost immediate blocking effect. The evidence suggests that the blocking site is at or close to the inner surface of the cellular membrane.
D000818:Animals; D001048:Aplysia; D001692:Biological Transport / Q000187:drug effects; D002110:Caffeine / Q000494:pharmacology*; D007700:Kinetics; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology*
D002110:Caffeine; D011188:Potassium