[Selective induction of tumors in Wistar rats with loop colostomy after administration of methyl-(acetoxymethyl)-nitrosamine (MAOMN) (author's transl)].
A single dose of 7 mg/kg methyl-(acetoxymethyl)-nitrosamine in Wistar rats with double loop colostomy induced adenomas, papillomas, and adenocarcinomas at the site of colostomy in 83% of the treated animals. The mean induction time was 320 days. The pronounced local effect as well as the high tumor yield are discussed in regard to the evident high epithelial sensitivity at the colostomy site.
D000230:Adenocarcinoma / Q000209:etiology; D000236:Adenoma / Q000209:etiology; D000818:Animals; D002273:Carcinogens; D003110:Colonic Neoplasms / Q000209:etiology; D003125:Colostomy; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives* / Q000633:toxicity; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000209:etiology*; D010212:Papilloma / Q000209:etiology; D051381:Rats; D013997:Time Factors
D002273:Carcinogens; C014659:methyl(acetoxymethyl)nitrosamine; D004128:Dimethylnitrosamine
Selektive Erzeugung von Tumoren an Wistar-Ratten an einem doppelläufigen Anus praeter nach Gabe von Methyl-(acetoxy-methyl)-Nitrosamin (MAOMN).