Sequence of centromere separation: analysis of mitotic chromosomes in man.
Mitotic chromosomes from human peripheral lymphocytes studied at the junction of metaphase and anaphase show that the centromeres of various chromosomes separate in a nonrandom, apparently genetically controlled sequence. It does not depend upon the position of the centromere in the chromosome, the length of the chromosome or total amount of detectable C-chromatin. In man, several chromosomes e.g. 18, 17, 2, separate very early. Such "early" cells do not include nos. 1, 13, 14, 15, and Y and very rarely nos. 21 and 22. The last separating chromosomes are those from group D, G, no. 1, 16, and Y. The possible implication of these findings in evolution, non-disjunction and the control of centromere separation sequences is discussed.
D000328:Adult; D000705:Anaphase; D002503:Centromere / Q000502:physiology*; D002875:Chromosomes / Q000502:physiology*; D002877:Chromosomes, Human / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008677:Metaphase