Immunosuppression by ochratoxin A and its prevention by phenylalanine.
Ochratoxin A, a toxin of Aspergillus ochraceus, suppresses the immune response to sheep erythrocytes in BALB/c mice at doses as low as 0.005 microgram/kg of body weight. This effect is prevented by phenylalanine.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D007108:Immune Tolerance / Q000187:drug effects*; D007166:Immunosuppressive Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009793:Ochratoxins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010649:Phenylalanine / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D009793:Ochratoxins; C025589:ochratoxin A; D010649:Phenylalanine