title: The antagonism between pineal peptides and catecholamines. I. The action of the pineal peptide extract on some effects of exogenous adrenaline in the rat.
abstract: The effects of adrenaline alone or associated with Crinofizin, a pineal polypeptide extract, were studied on rats. The drug given 15 minutes before a hyperglycemic adrenaline dose counteracted the pharmacologic effects with lethal consequences of catecholamine as well as certain metabolic effects such as elevation of blood levels of glycerol, phospholipids and cholesterol. Post-adrenaline hyperglycemia was not reduced by Crinofizin under the given experimental circumstances. The glycogenolytic effect of adrenaline was slightly inhibited.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D004837:Epinephrine / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005990:Glycerol / Q000097:blood; D006943:Hyperglycemia / Q000139:chemically induced; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D010743:Phospholipids / Q000097:blood; D010870:Pineal Gland / Q000032:analysis*; D051381:Rats; D013610:Tachycardia / Q000139:chemically induced
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D008112:Liver Glycogen; D010455:Peptides; D010743:Phospholipids; C016320:polypeptide pineal extract; D002784:Cholesterol; D005990:Glycerol; D004837:Epinephrine