Meptazinol and morphine compared: a study using systolic time intervals.
Changes in systolic time intervals following the administration of either morphine (0.1 mg/kg) or meptazinol (1 mg/kg) were studied in 12 patients admitted to hospital for intra-abdominal operations. The changes in these indices of cardiac performance were small. However, in 5 of the 6 patients who received morphine, the changes were in a direction suggesting negative inotropism, whereas the changes following meptazinol (6 patients) consistently suggested an improved ventricular performance.
D000328:Adult; D000368:Aged; D001381:Azepines / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008621:Meptazinol / Q000494:pharmacology*; D008875:Middle Aged; D009020:Morphine / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*; D013599:Systole / Q000187:drug effects*; D013997:Time Factors
D001381:Azepines; D008621:Meptazinol; D009020:Morphine