The preparation of amino bile acid derivatives.
Bile acid derivatives have been prepared by reaction of their mixed anhydrides with diaminoethane. The new compounds have side chains modified by amide bond formation which extends the side chain by two carbon atoms and terminates in a primary amino group. Important properties of the new compounds are their solubility in acid, and their ability to act as nucleophiles in the carbodiimide reaction or mixed anhydride reaction. The derivatives have been used to prepare high molar ratio immunogens with bovine serum albumin and to prepare 125I labelled ligands for radioimmunoassay.
D001647:Bile Acids and Salts; D055598:Chemical Phenomena; D002621:Chemistry; D002635:Chenodeoxycholic Acid / Q000031:analogs & derivatives; D002793:Cholic Acids; D010226:Parabens; D011869:Radioligand Assay / Q000379:methods; D012710:Serum Albumin, Bovine
D001647:Bile Acids and Salts; D002793:Cholic Acids; D010226:Parabens; D002635:Chenodeoxycholic Acid; D012710:Serum Albumin, Bovine; C030499:N-(2-aminoethyl)-3,7,12-trihydroxycholan-24-amide; C030600:N-(2-aminoethyl)-3,7-dihydroxycholan-24-amide