[Research on a new allergenic extract adsorbed on L-tyrosine. Pharmacological and immunotherapeutic findings].
Antigen-specific immunotherapy, whose usefulness has been widely and objectively documented in the last few years, and whose therapeutic effectiveness depends on the administration of high doses of antigen, exploits the use of retard allergenic extracts which turn out to be more tolerated, and liable to a lower occurrence of side-effects. The Authors describe the results obtained with pollinosis vaccine adsorbed on L-tyrosine and employed on 206 patients with seasonal allergic conditions. Pharmacological experiments were performed on these vaccines, to establish their general tolerability (on mice and guinea-pigs), their local tolerability and the prolonged tolerability on rats. The results of the pharmacological experiments show that the vaccine does not cause any side-effects or toxic phenomena, that the growth curve of the animals treated is superposable to that of the controls, and that the product is perfectly absorbed without irritation or phlogosis of the peripheral tissues. As far as the clinical data are concerned a high percentage of cases (56.6%) classified as "optimal" were observed, while only a low percentage (4.54%) showed results classified as "null". Concerning the occurrence and the frequency of side-effects we should like to point out that only in one of the 206 cases tested (0.48%) was there local itching. These data are particularly significant, when compared with the side effects registered during immunotherapy with the aqueous vaccines.
D000293:Adolescent; D000328:Adult; D000485:Allergens; D000818:Animals; D002648:Child; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011852:Radioallergosorbent Test; D051381:Rats; D012130:Respiratory Hypersensitivity / Q000628:therapy; D012882:Skin Tests; D014443:Tyrosine
D000485:Allergens; D014443:Tyrosine
Ricerche su un nuovo estratto allergenico adsorbito su L-tirosina. Indagini farmacologiche ed immunoterapiche.