Calcitonin and secretin inhibit bombesin-stimulated serum gastrin and gastric acid secretion in man.
The effect of intravenously administered calcitonin and secretin on bombesin-stimulated serum gastrin and gastric acid secretion was studied on  7 volunteers. Secretin G.I.H. (1 C.U./kg per h) and calcitonin (0.5 I.U./kg per h) significantly (P less than 0.05) inhibited the serum gastrin and gastric acid responses to bombesin-14 (90 pmol/kg per h). Inhibition of gastrin release could not fully account for the inhibition of gastric acid secretion.
D000328:Adult; D001839:Bombesin; D002116:Calcitonin; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides; D012633:Secretin
D005755:Gastrins; D010455:Peptides; D012633:Secretin; D002116:Calcitonin; D001839:Bombesin