Further studies on the immunoglobulin allotypes (Gm, Am and Km) in India.
A total of 652 sera from Delhi, Bombay and Madras were tested for G1m (f, z, a, x), G3m (b0, 1, 3, 5, c3, 5, g, s, t, and v), A2m (1 and 2) and Km (1). The results indicate marked north to south clinical variation in the haplotype distribution, with Gmz,a;g varying from 0.226 to 0.382, and Gmz,a,x;g varying from 0.072 to 0.181, while Gmf; b varies from 0.505 to 0.296 and Gmz,a;b varies from 0.155 to 0.052. These differences are further magnified between high castes in the north and low castes in the south. In addition, high castes in both the north and south have indications of Asian admixture. Finally the Gmz,a;b haplotype found in Indians, is probably of central Asian origin. The frequency of A2m (2) positive specimens shows a tendency to increase from north to south and this difference is accentuated between high castes in the north and low castes in the south. The frequency of Km1 did not show any significant variation by location or caste.
D006801:Humans; D007070:Immunoglobulin A / Q000235:genetics*; D007126:Immunoglobulin Allotypes / Q000235:genetics* / Q000276:immunology; D007074:Immunoglobulin G / Q000235:genetics*; D007194:India; D010641:Phenotype
D007070:Immunoglobulin A; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G