title: Influence of bioflavonoids on lysosomal acid hydrolases and lysosomal stability.
abstract: In rats treated with (+)-catechin or 0-(beta-hydroxyethyl) rutosides, the activity of lysosomal acid hydrolase, namely, beta-glucuronidase, beta-N-acetyl glucosaminidase and cathepsin D in serum, liver and kidney and the stability of liver lysosomes was studied. The activity of these enzymes in bioflavonoids treated tissues and serum decreased significantly. Analysis of liver lysosome-rich fraction revealed an appreciable increase in the total activity and significant decrease in the rate of release of beta-glucuronidase in bioflavonoids treated animals. The results may, therefore, suggest stabilization of lysosomes due to the administration of bioflavonoids.
mesh_terms: D000118:Acetylglucosaminidase / Q000378:metabolism; D000818:Animals; D002403:Cathepsins / Q000378:metabolism*; D005419:Flavonoids / Q000494:pharmacology*; D005966:Glucuronidase / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051381:Rats
chemical_list: D005419:Flavonoids; D006026:Glycoside Hydrolases; D005966:Glucuronidase; D000118:Acetylglucosaminidase; D002403:Cathepsins