Influence of bioflavonoids on the collagen metabolism in rats with adjuvant induced arthritis.
In rats with adjuvant induced arthritis, the effect of CA or HR on the metabolism of collagen in skin was studied. In untreated animals with adjuvant induced arthritis, the synthesis of collagen is decreased, the catabolism of newly formed collagen is intensified and the conversion of soluble collagen to insoluble collagen is impaired. Bioflavonoids were found to increase the collagen synthesis, accelerate the conversion of soluble collagen to insoluble collagen and inhibit the catabolism of soluble collagen. The beneficial action of bioflavonoids on the metabolism of collagen in adjuvant induced arthritis was discussed.
D000818:Animals; D001168:Arthritis / Q000378:metabolism*; D001169:Arthritis, Experimental / Q000188:drug therapy / Q000378:metabolism*; D002392:Catechin / Q000494:pharmacology; D003094:Collagen / Q000378:metabolism*; D005419:Flavonoids / Q000494:pharmacology*; D006896:Hydroxyethylrutoside / Q000494:pharmacology; D006909:Hydroxyproline / Q000652:urine; D008297:Male; D051381:Rats; D012867:Skin / Q000187:drug effects / Q000378:metabolism
D005419:Flavonoids; D006896:Hydroxyethylrutoside; D002392:Catechin; D003094:Collagen; D006909:Hydroxyproline