Effect of gelatin infusion on urinary excretion of water and electrolytes in rats.
The effect of gelatin infusion on water and electrolyte excretion in urine was studied by measuring the volume of excreted urine and the urinary excretion of Na+, K+, Ca++ and Mg++ in a group of male rats before and after receiving infusions of a 5% autoclaved gelatin solution containing 1% glycine (1 ml/100 g body). A similar group of rats received the diluent only (control group). The results obtained showed that the diluent had a diuretic and natriuretic effect but with a less marked degree than gelatin solution which caused marked diuresis, natriuresis and increased excretion of Ca++ and Mg++ in the urine. The K+ excretion was significantly decreased following gelatin infusion. All of these measurements returned to the base-line level after 72 h following gelatin infusion.
D000818:Animals; D001834:Body Water / Q000378:metabolism*; D002118:Calcium / Q000652:urine; D004573:Electrolytes / Q000652:urine*; D005780:Gelatin / Q000494:pharmacology*; D007700:Kinetics; D008274:Magnesium / Q000652:urine; D008297:Male; D011188:Potassium / Q000652:urine; D051381:Rats; D012964:Sodium / Q000652:urine
D004573:Electrolytes; D005780:Gelatin; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium