title: Renal failure as a complication of acute antihypertensive therapy.
abstract: Adult patients with long-standing hypertension have been reported to experience an impairment in renal function when treatment with potent vasodilating agents is initiated. To document that this sequence may occur in children as well, we report the case of a 4-year-old boy with renal disease in whom reduction of blood pressure to normal levels was accompanied on three occasions by oliguric renal failure. During each episode, the correlation between reduction in blood pressure and increase in serum creatinine level was significant (P less than .05); furthermore, the slope of the relationship was similar with each episode. This phenomenon suggests an impairment of renal autoregulation in this patient. Maintenance of normal blood pressure for several months was accompanied by a gradual return of renal function to pretreatment levels. This case suggests that particular attention should be paid to renal function during the initiation of antihypertensive therapy, particularly in patients with renal vascular damage. Present evidence does not appear to warrant modification of the current therapeutic philosophy of aggressive management in patients with severe hypertension.
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000959:Antihypertensive Agents / Q000009:adverse effects*; D001707:Biopsy, Needle; D001794:Blood Pressure; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects; D006973:Hypertension / Q000188:drug therapy*; D007668:Kidney / Q000648:ultrastructure; D008297:Male
chemical_list: D000959:Antihypertensive Agents; D006852:Hydrochlorothiazide; D003404:Creatinine