The effects of chloral hydrate anesthesia on the metabolic response in the substantia nigra to apomorphine.
The effects of apomorphine (1 mg/kg) upon glucose utilization in the substantia nigra (pars compacta) have been examined with 2-deoxyglucose autoradiography in conscious rats and rats anesthetized with chloral hydrate. In conscious rats, apomorphine increased glucose use by 23%, whereas in the anesthetized rats, apomorphine decreased glucose use by 24%. These divergent responses to apomorphine highlight the difficulties associated with the use of chloral hydrate anesthesia in the study of nigro-striatal systems.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D002697:Chloral Hydrate / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D008297:Male; D009434:Neural Pathways / Q000187:drug effects; D051381:Rats; D013378:Substantia Nigra / Q000187:drug effects*
D001786:Blood Glucose; D002697:Chloral Hydrate; D001058:Apomorphine