Lymphocytes that mediate systemic resistance to in vivo growth of a carcinogen-induced syngeneic tumor.
Wistar rats immunized with irradiated syngeneic methylcholanthrene-induced sarcoma, Mc7, are able to suppress a subsequent challenge of this tumor. Cells obtained from thoracic-duct lymph of these tumor-immunized animals and infused intravenously into normal syngeneic rats transfer specific tumor resistance to the recipients. These mediators of tumor resistance have the characteristics of T lymphocytes that are in a nonproliferating state and have an effective life span at least 2 weeks in normal recipient rats.
D000818:Animals; D002470:Cell Survival; D007109:Immunity; D007114:Immunization; D007136:Immunoglobulins / Q000032:analysis; D008214:Lymphocytes / Q000276:immunology*; D009368:Neoplasm Transplantation; D051381:Rats; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000276:immunology*; D013897:Thoracic Duct / Q000166:cytology; D014184:Transplantation, Homologous
D007136:Immunoglobulins