Effect of l-ascorbate 2-sulfate on fatty liver and hyperlipidemia induced by various treatments in rats and guinea pigs.
Effects of L-ascorbate 2-sulfate (AAS) on fatty liver and hyperlipidemia induced by various treatments were studied in rats and guinea pigs. L-Ascorbic acid (AA) (50 or 175 mg/kg), a reference compound, lowered the lipid levels in the serum and/or liver in guinea pigs, while AA had little effect in rats. On the other hand, AAS (300 mg/kg) was effective in both animals. In rats, AAS lowered cholesterol and triglycerides in the serum from ethionine-treated animals and in the liver from orotic acid-supplemented animals. In guinea pigs, this compound lowered cholesterol and triglycerides in the serum from ethionine-treated animals, lipids in the liver from cholesterol-supplemented animals, and lipids in the serum and liver from scorbutic animals. AA markedly increased the content of AA in the organs in all experiments, while AAS had a slight effect. Thus, it is suggested that AAS exerts its hypolipidemic and lipotropic effects by the specific actions of AAS.
D000818:Animals; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000032:analysis / Q000494:pharmacology; D002784:Cholesterol / Q000494:pharmacology; D005001:Ethionine / Q000494:pharmacology; D005234:Fatty Liver / Q000378:metabolism*; D005260:Female; D006168:Guinea Pigs; D006949:Hyperlipidemias / Q000378:metabolism*; D008055:Lipids / Q000032:analysis; D008297:Male; D009963:Orotic Acid / Q000494:pharmacology; D051381:Rats; D012614:Scurvy / Q000139:chemically induced; D013464:Sulfuric Acids / Q000494:pharmacology; D014280:Triglycerides / Q000032:analysis
D008055:Lipids; D013464:Sulfuric Acids; D014280:Triglycerides; C001956:ascorbic acid 2-sulfate; D009963:Orotic Acid; D002784:Cholesterol; D001205:Ascorbic Acid; D005001:Ethionine