title: Multicentric nature of vulvar carcinoma in situ.
abstract: A detailed histologic and DNA-microspectrophotometric study is presented of 31 lesions selected from 12 of 65 patients with vulvar carcinoma in situ whom the authors have seen. In 6 patients the lesions were multicentric and in 6 they were confluent. The purpose of the study was to determine whether or not there was a measurable biologic difference between these 2 distinctly different clinical lesions that would justify separating them into different categories. A hypothesis as to the clonal evolution of multicentric and confluent vulvar carcinoma is presented based on the authors' findings.
mesh_terms: D002278:Carcinoma in Situ / Q000032:analysis / Q000473:pathology*; D002453:Cell Cycle; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D013053:Spectrophotometry; D014844:Vulva / Q000473:pathology; D014846:Vulvar Neoplasms / Q000032:analysis / Q000473:pathology*
chemical_list: D004273:DNA, Neoplasm