Experimental treatment of cysticercosis with metrifonate.
Thirty cysticercous patients were treated with metrifonate in doses of 7.5 mg/kg given for five consecutive days, with intervals of two weeks until completion of six series. The symptoms originated by drug reaction were mild and transitory. The results obtained after treatment demonstrated the effectivity in cerebral ocular and musculocutaneous cysticercosis, corroborated by clinical evaluations like: neurological, ophtalmological and psychiatric examinations; routine laboratory tests; special examinations like indirect immunofluorescence and hemagglutination, immunoglobulin quantitation and cholinesterase activity and by special cabinet studies like electroencephalogram, retinal fluorangiography, axial computerized tomography. The postreatment observation time varied from six months to nine years; in no case reactivation was observed.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003551:Cysticercosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D004827:Epilepsy / Q000209:etiology; D005128:Eye Diseases / Q000209:etiology; D005260:Female; D006261:Headache / Q000209:etiology; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000209:etiology; D008875:Middle Aged; D011559:Pseudotumor Cerebri / Q000209:etiology; D014236:Trichlorfon / Q000009:adverse effects / Q000627:therapeutic use*
D014236:Trichlorfon