Plasma high-density lipoprotein cholesterol and hepatic cytochrome P-450 concentrations in epileptics undergoing anticonvulsant treatment.
Relation of plasma high-density lipoprotein (HDL) cholesterol concentration to hepatic microsomal enzyme activity in eighteen epileptics with diagnostic liver biopsy was investigated, the cytochrome P-450 content in biopsy samples being used to reflect the liver enzyme activity. A significant correlation (r = 0.67, P less than 0.01) was found. Combination therapy with anticonvulsants was associated with higher plasma HDL cholesterol and hepatic cytochrome P-450 concentrations than the treatment with phenytoin alone. Serum triglyceride level was inversely related to the hepatic cytochrome P-450 content (r = 0.62, P less than 0.01). Plasma HDL cholesterol and hepatic cytochrome P-450 were related to liver histology. Patients with hepatic fatty infiltration had low HDL cholesterol and cytochrome P-450 concentrations.
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D002648:Child; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004827:Epilepsy / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008099:Liver / Q000201:enzymology* / Q000473:pathology; D008297:Male
D000927:Anticonvulsants; D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D003577:Cytochrome P-450 Enzyme System; D002784:Cholesterol