title: Electrophysiologic and histologic correlations in chronic complete atrioventricular block.
abstract: Electrophysiologic studies using the His bundle electrogram (HBE) and histologic studies of serial sections of the conduction system were correlated in two groups of deceased patients. Group 1 consisted of five patients with chronic complete atrioventricular block (CAVB) who had narrow QRS complexes and AH block (block proximal to the His bundle deflection). Group 2 consisted of four patients with chronic CAVB who had wide QRS complexes and HV block (block distal to the His bundle deflection). In group 1, the sites of the main lesion were not located in the approaches to the atrioventricular (AV) node or the AV node, but were found in the penetrating portion of the His bundle in one patient and in the branching portion of the His bundle in three patients. In the remaining patient, the main site of block could not be demonstrated histologically in the AV conduction system, but marked fibrosis of the approaches to the sinoatrial node and surrounding atrial muscle was found. In all patients of group 2, the site of the main lesion was located in the bilateral bundle branches, and thus was compatible with so-called trifascicular block. This correlation study between the His bundle electrogram and histologic findings of the AV conduction system showed that in some cases, CAVB presenting as AH block on the HBE can be associated with a lesion in the branching portion of the His bundle (distal His), and that CAVB presenting as HV block on the HBE is associated with a bilateral lesion of the bundle branches.
mesh_terms: D000368:Aged; D001283:Atrioventricular Node / Q000473:pathology; D002036:Bundle of His / Q000503:physiopathology; D002908:Chronic Disease; D004562:Electrocardiography; D004594:Electrophysiology; D005260:Female; D006321:Heart / Q000033:anatomy & histology; D006327:Heart Block / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size