Synthesis and biological properties of pyrazo-[3,4-B]-pyridine derivatives. II.
By aminoalkylation with diethylaminoethyl chloride of 3-hydroxypyrazo-[3,4-b]-pyridine 1 and its phenyl derivative 2 as well as 3-aminopyrazo-[3,4-b]-pyridine 7 and its phenyl derivative 8, basic ethers 5, 6 and aminoalkanoloamines 9 and 10 have been obtained. Compounds 5, 6 and 10 increased coronary blood flow of the isolated cat heart. At the concentration of 5 +/- 2 mg/ml shoved spasmolytic activity.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis*; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D002415:Cats; D003331:Coronary Vessels / Q000187:drug effects; D004562:Electrocardiography; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D010276:Parasympatholytics / Q000138:chemical synthesis*; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology; D011817:Rabbits
D000889:Anti-Arrhythmia Agents; D000959:Antihypertensive Agents; D010276:Parasympatholytics; D011720:Pyrazoles; D011725:Pyridines