Steroid receptors in adjuvant hormonal therapy for breast cancer.
Using a computerized mathematical model the authors found that either a small [5%] or large [50%] hormone-dependent reduction in tumour cell population at the beginning of adjuvant chemotherapy for breast cancer greatly increases the probability fo achieving a cure. The fact that even a minor response to hormonal therapy early in the treatment of the tumor is effective underlines the importance of using estrogen receptors to to select potential responders in whom a cure is at least a strong theoretical possibility.
D001943:Breast Neoplasms / Q000032:analysis / Q000188:drug therapy / Q000628:therapy*; D002369:Castration; D005260:Female; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D008954:Models, Biological; D009376:Neoplasms, Hormone-Dependent / Q000628:therapy*; D011987:Receptors, Steroid / Q000032:analysis*
D006728:Hormones; D011987:Receptors, Steroid