[Effect of amino acid imbalance and ascorbic acid deficit on the carcinogenic effect of N-nitrosopiperidine].
A study was made of the effect of ascorbic acid deficiency and low levels of lysine, methionine and threonine on the cancerogenic effect of nitrosopiperidine which was fed to guinea-pigs with drinking water in a single dose of 4.25 mg/kg bw. Deficiency of the nutrients given alone or especially in combination speeded up the growth tumors induced by the cancerogenic agent. A possibility of inducing esophageal tumors in guinea-pigs has been demonstrated for the first time.
D000596:Amino Acids / Q000172:deficiency*; D000821:Animal Feed; D000818:Animals; D001206:Ascorbic Acid Deficiency / Q000150:complications*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology; D004938:Esophageal Neoplasms / Q000139:chemically induced / Q000473:pathology; D006168:Guinea Pigs; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D009602:Nitrosamines / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000473:pathology; D013997:Time Factors
D000596:Amino Acids; D009602:Nitrosamines; D010880:Piperidines; C002743:N-nitrosopiperidine
Deĭstvie disbalansa aminokislot i defitsita askorbinovoĭ kisloty na kantserogennyĭ éffekt N-nitrozopiperidina.