Hypersensitivity in rats infected with Fasciola hepatica: possible role in protection against a challenge infection.
Rats infected with Fasciola hepatica showed an increase in intestinal mast cells which reached a peak between four and six weeks and fell to control levels by week 14. Following a challenge infection sensitised rats showed evidence of a transitory mild intestinal anaphylactic response. The numbers of intestinal eosinophils, already increased as a result of the primary infection, were rapidly supplemented. In previously uninfected rats the majority of flukes penetrated the mid gut region, but in sensitised rats there was a shift towards the caecal end. Resistance to challenge and a pronounced intestinal eosinophil response were evident in previously infected rats irrespective of the presence or absence of detectable serum reaginic antibody. Systemic anaphylaxis, induced by intravenous fluke antigen administration, occurred whether serum reagins could be detected or not.
D000707:Anaphylaxis / Q000209:etiology* / Q000276:immunology; D000818:Animals; D000941:Antigens / Q000276:immunology*; D004804:Eosinophils / Q000166:cytology; D005210:Fasciola hepatica / Q000276:immunology*; D005211:Fascioliasis / Q000276:immunology*; D007421:Intestine, Small / Q000166:cytology / Q000276:immunology; D008297:Male; D008407:Mast Cells / Q000166:cytology; D051381:Rats; D011935:Reagins / Q000096:biosynthesis
D000941:Antigens; D011935:Reagins