Inhibition of the pendular movements of the intestine by aminoglycoside antibiotics.
In the present study the inhibitory effect of eight aminoglycoside antibiotics on the motility of the rabbit's intestine was investigated. We found that all the antibiotics tested exert inhibitory effect on the motility of the intestine and only quantitative differences exist between them. The inhibitory potency of the antibiotics appears to be as follows: gentamicin greater than amikacin greater than streptomycin greater than sisomicin greater than kanamycin greater than kanendomycin greater than dibekacin greater than tobramycin. The inhibitory effect of the above antibiotics is not exerted through the adrenergic receptors because this effect is also observed after the previous administration of alpha and beta adrenergic receptor blocking agents. Neostigmine is not able to restore the normal motility of the relaxed intestine. The normal pendular movements of the intestine are restored by calcium.
D000109:Acetylcholine / Q000378:metabolism; D000617:Aminoglycosides / Q000009:adverse effects; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004837:Epinephrine / Q000494:pharmacology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008297:Male; D009388:Neostigmine / Q000494:pharmacology; D011817:Rabbits
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D009388:Neostigmine; D000109:Acetylcholine; D004837:Epinephrine