title: Myelination of central nervous system axons in tissue culture by transplanted oligodendrocytes.
abstract: Unmyelinated mouse cerebellar cerebellar cultures in which oligodendrocyte differentiation had been suppressed by exposure to cytosine arabinoside developed axonal myelin after superimposition of kainic acid-treated cerebellar explants devoid of myelin-receptive axons. The latter explants contained differentiated oligodendrocytes. The operation of a diffusible myelin-stimulating factor was ruled out by the failure of myelination in cytosine arabinoside-exposed explants not in direct contact with oligodendrocyte-containing transplants.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001369:Axons / Q000187:drug effects / Q000502:physiology*; D002531:Cerebellum / Q000187:drug effects / Q000502:physiology*; D003094:Collagen; D003561:Cytarabine / Q000494:pharmacology; D007608:Kainic Acid / Q000494:pharmacology; D051379:Mice; D009186:Myelin Sheath / Q000187:drug effects / Q000502:physiology*; D009457:Neuroglia / Q000637:transplantation*; D009836:Oligodendroglia / Q000637:transplantation*; D009924:Organ Culture Techniques
chemical_list: D003561:Cytarabine; D003094:Collagen; D007608:Kainic Acid