title: Damage to testicular function in chronic renal failure of children.
abstract: The functional endocrine reserve of testes was studied in 58 boys before and during puberty at different stages of chronic renal failure. Plasma testosterone (T) and dihydro- T were measured before and seven days after stimulation with human chorionic gonadotrophin (HCG). The T response to HCG often appeared to be already subnormal in renal failure before puberty had started. A negative correlation was observed in prepubertal boys between serum creatinine and stimulated T levels before the start of dialysis. During puberty the response to HCG was lower in boys on conservative treatment and on haemodialysis than after transplantation.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D008297:Male; D011627:Puberty; D013737:Testis / Q000503:physiopathology*; D013739:Testosterone / Q000097:blood
chemical_list: D006063:Chorionic Gonadotropin; D013739:Testosterone