title: Cardiac effects of clonidine on isolated dog atria.
abstract: The effect of clonidine on pacemaker activity and contractility was studied in the isolated dog atrium which was perfused with arterial blood of the support dog. Clonidine caused dose-dependent negative chronotropic and inotropic effects, and a large dose of clonidine slightly suppressed the positive chronotropic and inotropic responses to norepinephrine and sympathetic cardiac nerve stimulation (5 and 30 Hz) but not consistently.
mesh_terms: D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects* / Q000294:innervation; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000502:physiology
chemical_list: D003000:Clonidine