In vitro activity of naftifine, a new antifungal agent.
Naftifine exhibits an interesting in vitro spectrum of activity against dermatophytes (38 strains; minimal inhibitory concentration [MIC] range 0.1 to 0.2 microgram/ml), aspergilli (6 strains; MIC range, 0.8 to 12.5 microgram/ml), Sporothrix schenckii (2 strains; MICs, 0.8 and 1.5 microgram/ml), and yeasts of the genus Candida (77 strains; MIC range, 1.5 to greater than 100 microgram/ml). Its degree of efficacy is unaffected by the organism density in the test medium, and it is primarily fungicidal against dermatophytes as well as yeasts. Its in vitro efficacy is pH dependent and rises with increasing pH values.
D000499:Allylamine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000588:Amines / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D003022:Clotrimazole / Q000494:pharmacology; D004058:Diffusion; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D014047:Tolnaftate / Q000494:pharmacology
D000588:Amines; D000935:Antifungal Agents; D014047:Tolnaftate; D000499:Allylamine; C029178:naftifine; D003022:Clotrimazole