Evolution of lipoprotein patterns in newborns.
The plasma levels of total and high-density lipoprotein cholesterol and of the major apolipoproteins (apo B and apo A-I) were studied in 30 newborns, on cord blood and after 7 and 30 days of life. The evolution of these parameters during the first month of life shows that newborns have low LDL cholesterol and apo B levels at birth, which increase drastically during the first week and remain constant between 7 and 30 days. The HDL cholesterol and apo A-I levels are proportionally high at birth and keep increasing slowly up to 30 days. During this period, the cholesterol/apoprotein ratio remains constant in the LDL and HDL class. These data suggest that lipid and apoprotein levels at 7 days are more representative than cord-blood levels and more meaningful for a screening of congenital hypercholesterolemia. The cholesterol/apo B and apo B/apo A-I ratios, which are considered to be better predictive factors for atherosclerosis, should be included as screening parameters.
D001053:Apolipoproteins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D006801:Humans; D006937:Hypercholesterolemia / Q000175:diagnosis; D007231:Infant, Newborn; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008403:Mass Screening / Q000379:methods; D013997:Time Factors
D001053:Apolipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D002784:Cholesterol