Freeze-fracture studies of muscle caveolae in human muscular dystrophy.
Freeze-fracture studies of caveolar density and distribution were carried out in skeletal muscle plasma membrane from 6 patients with Duchenne muscular dystrophy (DMD), 5 patients with facioscapulohumeral dystrophy (FSH), 5 patients with myotonic dystrophy (MyD) and 5 normal control subjects. The results showed a significant increase in the number of caveolae and a decrease in size in a population of muscle plasma membranes from patients with DMD. No significant changes in the caveolae were observed in muscle plasma membranes from patients with FSH and MyD.
D000328:Adult; D002462:Cell Membrane / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005614:Freeze Fracturing / Q000379:methods*; D006801:Humans; D008297:Male; D009132:Muscles / Q000032:analysis / Q000473:pathology*; D009136:Muscular Dystrophies / Q000473:pathology*; D013848:Thigh