[Characteristics of the reparative processes in the gastric mucosa in gastroduodenal ulcer].
Comparative studies of reparative processes in the gastric mucosa were carried out in 96 experimental mice with acute (immobilization) and chronic (acetic acid applications) gastric ulcerations. The common features in both models of ulcerations were revealed: (1) marked reduction of the regeneratory potentials of the epithelium of the entire gastric mucosa early in the ulcer formation as an expression of a stress-reaction; (2) gradual increase of a proliferation pool more marked at the site of the ulcer formation; (3) a sharp increase in the number of DNA-synthesizing cells in the ulcer edges by the time of its morphological formation; (4) extension of the zone of DNA-synthesizing cells with the progression of proliferative processes in the gastric mucosa. The time course of morphological alterations in the gastric mucosa developing in immobilization stress and acetic acid applications reflects the regularities of the development of both local and general reactions of the compensatory-adaptative nature.
D000085:Acetates / Q000494:pharmacology; D000818:Animals; D005753:Gastric Mucosa / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009336:Necrosis; D010437:Peptic Ulcer / Q000473:pathology*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology; D013312:Stress, Physiological / Q000473:pathology; D013997:Time Factors
D000085:Acetates
Osobennosti reparativnykh protsessov slizistoĭ obolochki zheludka pri gastroduodenal'nykh iz"iazvleniiakh.