The clinical relevance of ferritin concentration in the cerebrospinal fluid.
By means of a new technique (Particle Counting Immunoassay), we have determined the level of ferritin in 470 samples of cerebrospinal fluid of patients with various neurological disorders. The median value obtained in a control group was 2.3 ng/ml with an upper limit at 5.5 ng/ml. the concentrations in the serum and cerebrospinal fluid were independent, but that in cerebrospinal fluid correlated with its total protein content. High values of ferritin were found in infectious meningo-encephalitis, in vascular diseases of the central nervous system, and, unexpectedly, in several cases of dementia without obvious vascular pathology.
D001424:Bacterial Infections / Q000134:cerebrospinal fluid; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid; D002543:Cerebral Hemorrhage / Q000134:cerebrospinal fluid; D002561:Cerebrovascular Disorders / Q000134:cerebrospinal fluid; D003704:Dementia / Q000134:cerebrospinal fluid; D004660:Encephalitis / Q000134:cerebrospinal fluid; D005293:Ferritins / Q000134:cerebrospinal fluid*; D006406:Hematoma / Q000134:cerebrospinal fluid; D006801:Humans; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid*; D014777:Virus Diseases / Q000134:cerebrospinal fluid
D005293:Ferritins