Effects of glucocorticoids on hormone-stimulated lipolysis and calcium uptake in the adipose cells.
Hormone-induced lipolysis and calcium accumulation were concomitantly reduced in the adipose tissue from adrenalectomized rats. In contrast, both epinephrine-activated lipolysis and calcium accumulation were potentiated when the adipocytes were preincubated with 33 ng/ml of dexamethasone for 3 hrs. These potentiating effects of dexamethasone on epinephrine-stimulated lipolysis were completely inhibited when the adipocytes were preincubated with the steroid and verapamil which inhibited hormone-induced calcium influx into the adipocytes. These findings suggest that the potentiating effect of glucocorticoid on hormone-stimulated lipolysis depends upon its accelerating action on hormone-induced calcium influx into the adipocytes.
D000273:Adipose Tissue / Q000378:metabolism*; D000315:Adrenalectomy; D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003907:Dexamethasone / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology*; D008066:Lipolysis / Q000187:drug effects*; D051381:Rats; D014700:Verapamil / Q000494:pharmacology
D005938:Glucocorticoids; D000628:Aminophylline; D003907:Dexamethasone; D014700:Verapamil; D002118:Calcium; D004837:Epinephrine