Studies on the mechanism of drug-induced lipidosis. Cationic amphiphilic drug inhibition of lysosomal phospholipases A and C.
D000547:Amantadine / Q000494:pharmacology*; D000814:Aniline Compounds / Q000494:pharmacology; D000818:Animals; D002745:Chlorphentermine / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D006536:Heptanes / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D008064:Lipidoses / Q000139:chemically induced / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D010600:Pharmacology; D010740:Phospholipases / Q000037:antagonists & inhibitors*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D014309:Tripelennamine / Q000494:pharmacology; D010738:Type C Phospholipases / Q000037:antagonists & inhibitors*
D000814:Aniline Compounds; D006536:Heptanes; C016921:1,7-bis(p-aminophenoxy)heptane; D014309:Tripelennamine; D011433:Propranolol; D000547:Amantadine; D010740:Phospholipases; D010741:Phospholipases A; D010738:Type C Phospholipases; D002745:Chlorphentermine; D007099:Imipramine; D002746:Chlorpromazine