A re-evaluation of acetylcholine receptors on feline Renshaw cells.
1 The effects of atropine, methylatropine and lachesine administered by ionophoresis were examined on responses of Renshaw cells to acetylcholine, acetyl-beta-methylcholine, nicotine and DL-muscarine in cats anaesthetized with pentobarbitone or chloralose. 2 The antagonists were as effective in antagonizing excitation by nicotine as they were in antagonizing excitation by acetylcholine and were only slightly more effective in antagonizing excitation by acetyl-beta-methylcholine. 3 These results are discussed in relation to the characterization of acetylcholine receptors on Renshaw cells. 4 It is concluded that there are two distinct populations of receptors but that the nicotinic receptors are non-selective in their activation by agonists and antagonists, whereas the muscarinic receptors display greater selectivity.
D000109:Acetylcholine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002415:Cats; D004558:Electric Stimulation; D007395:Interneurons / Q000187:drug effects*; D009538:Nicotine / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011976:Receptors, Muscarinic / Q000187:drug effects; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects*
D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D009538:Nicotine; D001285:Atropine; D000109:Acetylcholine