The influence of sodium 8-chlorotheophyllinate (S8CT) on immune processes.
S8CT injected at the time of immunization significantly enhances specific IgM-production but has no effect on IgG-formation. Mitogen (PHA-P) induced macrophage migration inhibition of cells of S8CT pretreated animals is reduced. The same effect is observed, when normal cells are tested in the presence of S8CT in vitro. Blast transformation of B-lymphocytes but not of thymocytes is significantly stimulated by S8CT. Acid phosphatase activity is also stimulated in B-cells and - to a lesser degree - in cortisone-resistant T-lymphocytes whereas the activity of the total thymocyte population is reduced. No effect was seen on phagocytosis and intracellular bactericidal activity. A stimulatory effect of S8CT for B-cells is postulated.
D000135:Acid Phosphatase / Q000378:metabolism; D000917:Antibody Formation / Q000187:drug effects*; D002464:Cell Migration Inhibition; D007111:Immunity, Cellular / Q000187:drug effects*; D008213:Lymphocyte Activation / Q000187:drug effects; D008264:Macrophages / Q000276:immunology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D013806:Theophylline / Q000031:analogs & derivatives* / Q000494:pharmacology
D010726:Phosphodiesterase Inhibitors; D013806:Theophylline; D000135:Acid Phosphatase; C030093:8-chlorotheophylline