Effect of intravenous melperone on atrial repolarization in man.
The effect of 10 mg of melperone intravenously on the duration of the right atrial monophasic action potential was studied in seven patients and one healthy volunteer. Melperone induced an increase of the atrial monophasic action potential duration by 13%, 15 min after intravenous injection of the drug. This prolongation was a consistent finding but was within the limits of normal intra-individual variation and considerably smaller than normal inter-individual differences. However, the observations warrant studies to evaluate the effect of the drug in different cardiac arrhythmias.
D000200:Action Potentials / Q000187:drug effects; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D002090:Butyrophenones / Q000494:pharmacology*; D004341:Drug Evaluation; D005260:Female; D006325:Heart Atria / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged
D002090:Butyrophenones; C008522:metylperon