[Immuno-allergological study on 30 atopic patients (author's transl)].
An immuno-allergological study was performed on 30 atopic patients and the data were compared to those of 30 healthy controls. The findings were: --increased level of IgE class immunoglobulins in the atopic patients; --increased frequency of the presence of specific reagin to numerous allergens in the sera of atopics (RAST). The total amount of IgE was related to the presence of numerous and/or strongly positive RAST; --immediate hypersensitivity reaction (IHR) to various allergens and specially house-dust. No well-definite correlation was found between IHR and RAST for the same allergens and between the in vitro determination of allergens and a known history of clinical provocation by these allergens. The frequency of positive IHR was related with high level of total IgE; --decreased frequency of delayed cutaneous hypersensitivity tests and specially of those with candidin extracts. Cutaneous hyporeactivity to natural antigens was in relation with high level of total IgE; --no significant statistical difference was found between the amount of T and B lymphocytes; --increased frequency of HLA-A2 group and decreased frequency of HLA-B7 group.
D003876:Dermatitis, Atopic / Q000276:immunology*; D004391:Dust; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis; D006969:Hypersensitivity, Immediate / Q000175:diagnosis; D007073:Immunoglobulin E / Q000032:analysis; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology; D012882:Skin Tests
D004391:Dust; D006680:HLA Antigens; D007073:Immunoglobulin E
Exploration immuno-allergologique de 30 sujets atopiques.