title: Delayed-alternation performance after selective lesions of the medial and sulcal prefrontal cortex of the guinea pig.
abstract: The sulcal or medial subdivision of the prefrontal cortex of the guinea pig was ablated after the animals had learned a spatial delayed-alternation task. Retention of this task was significantly impaired only after ablation of the medial prefrontal cortex. As the most critical cortical region for delayed-alternation performance in the rat is also situated in the medial prefrontal cortex, our findings suggest a close functional correspondence of the prefrontal cortices of these rodent species.
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D005625:Frontal Lobe / Q000502:physiology*; D006168:Guinea Pigs; D008297:Male; D009949:Orientation / Q000502:physiology; D012055:Reinforcement Schedule; D012153:Retention, Psychology / Q000502:physiology; D013028:Space Perception / Q000502:physiology*; D013787:Thalamic Nuclei / Q000502:physiology