Novel metabolites from Penicillium crustosum, including penitrem E, a tremorgenic mycotoxin.
Two new indolic metabolites were isolated from Penicillium crustosum and separated from other penitrem mycotoxins by high-performance liquid chromatography. Penitrem D is a deoxy-penitrem A. Penitrem E is dechloro-penitrem A and was shown to be tremorgenic in mice, although it has only one-third of the activity of penitrem A. Roquefortine was also shown, for the first time, to be an important metabolic product of P. crustosum.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002853:Chromatography, Liquid; D004873:Ergolines / Q000302:isolation & purification; D006576:Heterocyclic Compounds, 4 or More Rings; D007211:Indoles; D051379:Mice; D009183:Mycotoxins / Q000302:isolation & purification*; D010407:Penicillium / Q000378:metabolism*; D010879:Piperazines; D014202:Tremor / Q000139:chemically induced
D004873:Ergolines; D006576:Heterocyclic Compounds, 4 or More Rings; D007211:Indoles; D009183:Mycotoxins; D010879:Piperazines; C003626:tremortin; C012536:roquefortine