title: CI-867, a new semisynthetic penicillin: in vitro studies.
abstract: CI-867, a new semisynthetic penicillin, has exhibited broad-spectrum activity in vitro against gram-positive cocci, except penicillin G-resistant Staphylococcus aureus, and against gram-negative bacilli. It was especially active against Pseudomonas aeruginosa and as active as mezlocillin and piperacillin against Klebsiella pneumoniae. CI-867 was bactericidal against most organisms. Its activity was greatly reduced when the inoculum was increased from 10(5) to 10(7) organisms per ml.
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology*
chemical_list: D010406:Penicillins; C020600:CI 867