title: Ionic fluoride: a study of its physiological variation in man.
abstract: The serum ionic fluoride concentrations in 497 normal individuals, from areas with non-fluoridated water supplies, ranged from 0.25 to 2.20 micromol F-/1 and were positively correlated with age (r = 0.31, p less than 0.001). Distribution of the data with age, coupled with the distribution of serum calcium with age, suggests a possible change in bone metabolism between 26 and 35 years of age. Serum fluoride levels vary with the time of day with a mean minimum value at 0800 and a mean peak value at 2200. Renal clearance studies gave fluoride ion clearances ranging from 19.5 to 44.0 ml/min and tubular reabsorption of fluoride ion ranging from 61.5 to 86.5%. After oral ingestion of 0.48 mmol sodium fluoride, peak serum levels occurred at 60 to 90 minutes; the peak levels were significantly higher in women than in men.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D002118:Calcium / Q000097:blood; D002940:Circadian Rhythm; D005215:Fasting; D005260:Female; D005459:Fluorides / Q000097:blood* / Q000652:urine; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012737:Sex Factors; D012969:Sodium Fluoride
chemical_list: D012969:Sodium Fluoride; D005459:Fluorides; D002118:Calcium