title: Binding parameters of defined immune complexes to rat basophilic leukaemia (RBL) cells.
abstract: The binding parameters of chemically-defined immune complexes composed of rat IgGa-anti-human serum albumin (HSA) to rat basophilic leukaemia cells were analysed. It was demonstrated that the uptake of various sized immune complexes is time-, temperature- and pH-dependent. A higher binding rate was observed with more Fc portions available in the immune complex. A comparison of the binding rate for immune complexes with that of heat aggregates shows that immune complexes bind with greater affinity to the cells.
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology*; D001491:Basophils / Q000276:immunology*; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D007074:Immunoglobulin G / Q000276:immunology; D007700:Kinetics; D007942:Leukemia, Experimental / Q000276:immunology*; D051381:Rats; D013997:Time Factors
chemical_list: D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G