title: A route to tritium labelled 11-methyl prostaglandins.
abstract: Labelled 11-methyl prostaglandins have been prepared via the catalytic tritium reduction of 11-iodomethyl intermediates. Two examples are reported for the preparation of such 11-iodomethyl precursors in which the desired lower side chain is attached in non-radioactive steps. Subsequent tritium hydrogenolysis of the 11-iodomethyl lactones followed by addition of the delta 5 cis-double bond yielded prostaglandins having specific activities of 10-15 Ci/mmol.
mesh_terms: D007553:Isotope Labeling / Q000379:methods*; D008745:Methylation; D011453:Prostaglandins; D014316:Tritium
chemical_list: D011453:Prostaglandins; D014316:Tritium