Effect of methylmercury and inorganic mercury on the nerve growth factor-induced neurite outgrowth in chick embryonic sensory ganglia.
Methylmercury inhibited the fiber outgrowth in chick embryonic sensory ganglia in the presence of nerve growth factor (NGF) by 50% at 2 x 10(-6) M and completely depressed it at 5 x 10(-6) M. Whereas inorganic mercury completely inhibited the fiber outgrowth at 10(-4) M. The possible role of microtubules is discussed.
D000818:Animals; D002642:Chick Embryo; D005724:Ganglia / Q000187:drug effects*; D008628:Mercury / Q000633:toxicity*; D008767:Methylmercury Compounds / Q000633:toxicity*; D008870:Microtubules / Q000187:drug effects; D009412:Nerve Fibers / Q000187:drug effects; D009414:Nerve Growth Factors / Q000494:pharmacology*; D012677:Sensation
D008767:Methylmercury Compounds; D009414:Nerve Growth Factors; D008628:Mercury