Effects of saccharin on primary humoral antibody production in rats.
Rats for 25 to 54 days with diets containing high concentrations (1;2.5; 5%) of saccharin showed marked, dose-dependent suppression of primary humoral antibody production against heterologous erythrocytes. Phytohemagglutinin (PHA)-induced blastogenesis was not consistently affected by these saccharin-containing diets.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D010835:Phytohemagglutinins / Q000494:pharmacology; D051381:Rats; D012439:Saccharin / Q000633:toxicity*
D010835:Phytohemagglutinins; D012439:Saccharin