Acute immune intravascular hemolysis due to hydrochlorothiazide.
Acute near-fatal intravascular hemolysis and renal failure developed in a patient after he had ingested 15 to 20 tablets of both methyldopa (Aldomet) nd hydrochlorothiazide (HydroDiuril). Serologic test results were inconsistent with those associated with methyldopa-induced hemolytic anemia and suggested that hemolysis was caused by hydrochlorothiazide antibodies reacting by an immune complex mechanism.
D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced* / Q000150:complications; D000328:Adult; D000743:Anemia, Hemolytic / Q000097:blood / Q000139:chemically induced* / Q000150:complications; D000906:Antibodies / Q000032:analysis; D000936:Antigen-Antibody Complex; D001789:Blood Group Antigens; D003298:Coombs Test; D004903:Erythrocyte Aggregation; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D008750:Methyldopa / Q000009:adverse effects; D013406:Suicide, Attempted
D000906:Antibodies; D000936:Antigen-Antibody Complex; D001789:Blood Group Antigens; D006852:Hydrochlorothiazide; D008750:Methyldopa