title: Withdrawal symptoms after graduated cessation of imipramine in children.
abstract: In a systematic retrospective study the authors reviewed charts of 22 depressed children on a clinical research unit who were withdrawn from high-dose imipramine. Significant withdrawal symptoms were found over seven symptom categories despite an average tapering period of 6.4 days. These results suggest that withdrawal symptoms in children may be much more prevalent and intense than previously recognized.
mesh_terms: D000855:Anorexia / Q000209:etiology; D002648:Child; D003866:Depressive Disorder / Q000188:drug therapy; D005221:Fatigue / Q000209:etiology; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology; D006261:Headache / Q000209:etiology; D006801:Humans; D007099:Imipramine / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D001523:Mental Disorders / Q000209:etiology; D007319:Sleep Initiation and Maintenance Disorders / Q000209:etiology; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis*
chemical_list: D007099:Imipramine