title: The osmotic pump: novel research tool for optimizing drug regimens.
abstract: Evaluation and selection of drugs, and determination of the optimal regimen, for controlled-release pharmaceutical products necessitate the reassessment of the pharmacology of drugs delivered at controlled rates. We have developed osmotic pumps for this purpose. These pumps, 1- and 2-week duration implants for animal studies, and 12- and 24-hour forms for oral and rectal administration in clinical studies, provide precise, accurate control over rate and duration of systemic or local drug delivery.
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004285:Dogs; D005069:Evaluation Studies as Topic; D006801:Humans; D051379:Mice; D008962:Models, Theoretical; D009997:Osmotic Pressure; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D051381:Rats
chemical_list: D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations