[Creatine kinase activity and isoenzymic spectrum of myocardium creatine kinase in rats of different age].
In old rats the specific activity of creatine kinase (EC 2.7.32) in homogenate, mitochondrial and postmitochondrial fractions of the myocardium is essentially lower than in adult animals. It does not change with age in myofibrils. The isoenzymic spectrum of creatine kinase is unchanged as well. In old rats the content of creatine phosphate in the myocardium is considerably lower, and that of creatine is higher than in young animals. This evidences for a decrease in the rate of creatine phosphorylation controlled by creatine kinase.
D000375:Aging; D000818:Animals; D003402:Creatine Kinase / Q000378:metabolism*; D006321:Heart / Q000254:growth & development*; D007527:Isoenzymes; D009206:Myocardium / Q000201:enzymology*; D051381:Rats
D007527:Isoenzymes; D003402:Creatine Kinase
Kreatinkinaznaia aktivnost' i izofermentnyĭ spektr kreatinkinazy miokarda krys raznogo vozrasta.