Failure of furazolidone in the treatment of onchocerciasis.
12 adult onchocerciasis patients from the rain forest zone of Nigeria were treated with furazolidone in divided daily doses ranging from 5--15 mg per kg body weight for 7--21 days to a maximum total dose of 6.3 g. The drug showed neither micro- nor macrofilaricidal activity against Onchocerca volvulus.
D000293:Adolescent; D000328:Adult; D000818:Animals; D005260:Female; D005664:Furazolidone / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008842:Microfilariae / Q000187:drug effects; D008875:Middle Aged; D009549:Nigeria; D009854:Onchocerca / Q000187:drug effects; D009855:Onchocerciasis / Q000188:drug therapy* / Q000469:parasitology; D012867:Skin / Q000469:parasitology
D005664:Furazolidone