Synergism, antagonism, and additivity of phenol, pentachlorophenol, and dinitrophenol to a fish (Notopterus notopterus).
The toxicity of phenol (P), pentachlorophenol (PCP), and dinitrophenol (DNP) was determined separately and in different combinations with a test fish, Notopterus notopterus, using the procedure of Schubert et al. (1978) that provided a simple, sensitive, and quantitative index of synergism, antagonism and additivity. The combination (P + DNP)/PCP was found to be the most synergistic, while (PCP + DNP)/P was antagonistic in nature. The (DNP + P)/PCP combination was additive in its effect. The other combinations were also synergistic, but to a lesser extent than the (P + DNP)/PCP combination.
D000818:Animals; D002733:Chlorophenols / Q000633:toxicity*; D004140:Dinitrophenols / Q000633:toxicity*; D004347:Drug Interactions; D005399:Fishes / Q000502:physiology*; D010416:Pentachlorophenol / Q000633:toxicity*; D019800:Phenol; D010636:Phenols / Q000633:toxicity*
D002733:Chlorophenols; D004140:Dinitrophenols; D010636:Phenols; D019800:Phenol; D010416:Pentachlorophenol