Manganese antagonizes the inhibitory effect of fluoride on the glucose metabolism of Streptococcus mutans.
Manganese stimulated the utilization of glucose by Streptococcus mutans, Streptococcus sanguis, Streptococcus mitior and Streptococcus milleri. S. mutans serotype c strains formed larger amounts of intracellular polysaccharide, lactic acid and produced a lower terminal pH in glucose broth when grown in the presence of 0.5 mM Mn. Manganese stimulated the utilization of glucose by resting cell suspensions of each of the four oral streptococcal species examined. Fluoride inhibited the utilization of glucose by the streptococci and Mn, but not calcium or magnesium, was found to counteract the inhibitory effect of fluoride.
D005459:Fluorides / Q000037:antagonists & inhibitors*; D005947:Glucose / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000096:biosynthesis; D019344:Lactic Acid; D008345:Manganese / Q000494:pharmacology*; D011135:Polysaccharides, Bacterial / Q000096:biosynthesis; D012969:Sodium Fluoride / Q000037:antagonists & inhibitors*; D013295:Streptococcus mutans / Q000187:drug effects* / Q000254:growth & development
D007773:Lactates; D011135:Polysaccharides, Bacterial; D019344:Lactic Acid; D008345:Manganese; D012969:Sodium Fluoride; D005947:Glucose; D005459:Fluorides