title: HLA antigens in mucocutaneous lymph node syndrome in New England.
abstract: HLA antigens were evaluated in 27 patients with mucocutaneous lymph node syndrome (Kawasaki disease) in the Boston area. In contrast to previous Japanese studies, no increase of HLA-Bw22 was found. A significant increase (P less than .002), however, in HLA-Bw51 was found in the patients with mucocutaneous lymph node syndrome as compared to an appropriate control population. To our knowledge, this is only the second disease associated with HLA-B5 specificity. The observations illustrate the lack of unified genetic predisposition for a such disease in two ethnic groups, white and Japanese. Such findings may have genetic implications regarding interhuman variation in immune responsiveness.
mesh_terms: D001900:Boston; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens / Q000032:analysis* / Q000276:immunology; D006801:Humans; D008206:Lymphatic Diseases / Q000276:immunology*; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000453:epidemiology / Q000276:immunology*; D010641:Phenotype
chemical_list: D006680:HLA Antigens