[Determination of adenine nucleotide and inorganic phosphate contents of liver of rats with E-hypovitaminosis and administration of alpha-tocopherol and ubiquinone-9].
It is shown that in the rat liver with E-hypovitaminosis the ATP content, sum of adenine nucleotides, and the phosphate potential value ([ATP]/[ADP.]Pi) decrease, whereas the amount of ADP, AMP and Pi remains practically unchanged. 3h after intravenous administration of alpha-tocopherol of ubiquinone to rats with E-hyovitaminosis the mentioned indices normalize, which evidences for a considerable increase in the level of bioenergetic processes. The direction of the mentioned changes corresponds to changes in the ubiquinone content and activity of the respiratory chain redox enzymes. The participation of vitamin E in processes of oxidative phosphorylation may be connected with the metabolism control and ubiquinone functioning.
D000244:Adenosine Diphosphate / Q000378:metabolism*; D000249:Adenosine Monophosphate / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism*; D051381:Rats; D014451:Ubiquinone / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology*; D014811:Vitamin E Deficiency / Q000378:metabolism*
D010710:Phosphates; D014451:Ubiquinone; D014810:Vitamin E; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; C030571:ubiquinone 9
Opredelenie soderzhaniia adeninnukleotidov i neorganicheskogo fosfata v pecheni krys pri E-gipovitaminoze i vvedenii al'fa-tokoferola i ubikhinoma-9.