[Lipid transport by serum albumin in normal conditions and diseases of the hepatopancreatoduodenal system].
The content of lipids transported by serum albumin was determined in healthy people and in patients suffering from diseases of the hepatopancreatoduodenal zone. The method of gas-liquid chromatography detected 30 fatty acids and the components of steroid nature lipid extracts of albumin. The content of oleic, palmitic, linoleic, stearic and arachidonic acids in the extracts is the highest. Their amount in norm is 75% of all fatty acids. It is shown that bilirubin displaces steroids from the sites of their fixation in albumin. With diseases of the hepatopancreatoduodenal zone serum albumin transports a greater amount of fatty acids with C14-C19 and less amount of those with C20-C25. A constant decrease in the arachidonic acid content is the most typical of the hepatobiliary system diseases.
D001663:Bilirubin / Q000097:blood; D001667:Binding, Competitive; D002849:Chromatography, Gas; D004378:Duodenal Diseases / Q000097:blood*; D005227:Fatty Acids / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood*; D008107:Liver Diseases / Q000097:blood*; D010182:Pancreatic Diseases / Q000097:blood*; D012016:Reference Values; D012709:Serum Albumin / Q000378:metabolism*
D005227:Fatty Acids; D008055:Lipids; D012709:Serum Albumin; D001663:Bilirubin
Transport lipidov syvorotochnym al'buminom v norme i pri zabolevaniiakh gepatopankreatoduodenal'noĭ zony.