The fibrinolytic activity of isolated rat glomeruli by fibrin slide technique. Its application to rat Masugi nephritis.
A method for measurement of rat glomerular fibrinolysis and the results of its application to rat Masugi nephritis are described. The glomerular fibrinolytic activity was measured on isolated glomeruli using a fibrin slide technique. The procedure of this method is simple and the results obtained have a good reproducibility. By applying this method to rat Masugi nephritis, sequential changes in glomerular fibrinolytic activity could be assessed. A decrease in glomerular fibrinolytic activity that was related to the extent of fibrin deposits in the glomeruli was demonstrated in the autologous phase.
D000818:Animals; D003176:Complement C3 / Q000032:analysis; D005260:Female; D005340:Fibrinogen; D007074:Immunoglobulin G / Q000032:analysis; D066298:In Vitro Techniques; D007678:Kidney Glomerulus / Q000378:metabolism*; D008297:Male; D008722:Methods; D009393:Nephritis / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D013917:Thrombin; D014148:Tranexamic Acid / Q000494:pharmacology; D014594:Uterine Neoplasms / Q000473:pathology*
D003176:Complement C3; D007074:Immunoglobulin G; D014148:Tranexamic Acid; D005340:Fibrinogen; D013917:Thrombin