[Quantitative study of endothelial defects in the aorta and carotid artery in experimental atherosclerosis].
The inner surface of the aorta and carotid artery in normal rabbits (group 1) and after 3 weeks (group 2), 6 weeks (group 3) and 8 months (group 4) of hypercholesterolemia was studied by scanning electron microscopy. In all the cases the area of de-endothelialized zones was equally small. Incidence of microdefects in the endothelium (argyrophilic cells, craters and stomata) increased in group 2, but decreased in group 3 and group 4 (outside the plaques). No typical endothelium with argyrophilic borders was observed on 39.2% of the plaque surface in group 4, though the cells were present. The data obtained show that vast zones of de-endothelialization do not precede the development of atherosclerotic plaques.
D000818:Animals; D001011:Aorta / Q000648:ultrastructure*; D001161:Arteriosclerosis / Q000473:pathology*; D002339:Carotid Arteries / Q000648:ultrastructure*; D004727:Endothelium / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D011817:Rabbits; D013052:Spectrometry, X-Ray Emission; D013997:Time Factors
Kolichestvennoe izuchenie defektov éndoteliia aorty i sonnoĭ arterii pri éksperimental'nom ateroskleroze.