Roles of high blood glucose concentration during hemorrhagic shock in alloxan diabetic rats.
Severe alloxan diabetic rats (blood glucose levels, n = 6, 624 +/- 29 mg/dl; peripheral immunoreactive insulin levels (IRI), n = 6, 5.4 +/- 0.9 microU/ml) which had shown impaired mitochondrial phosphorylative activities and low mitochondrial oxidation-reduction states were bled to a mean blood pressure of 40 mm Hg and maintained for 2 hours according to a modified Wiggers' method. Within 2 hours after the induction of shock blood glucose levels rose to still higher levels but no animals died. Roles of hyperglycemia and gluconeogenesis in hemorrhagic shock were discussed, comparing with earlier irreversible results in jaundiced rats that had shown rapid decreases in blood glucose levels and mitochondrial phosphorylative activities in a previous study with rats in hemorrhagic shock.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology; D010766:Phosphorylation; D051381:Rats; D012771:Shock, Hemorrhagic / Q000378:metabolism*
D001786:Blood Glucose; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate