Induction of fibroblast chemotaxis by fibronectin. Localization of the chemotactic region to a 140,000-molecular weight non-gelatin-binding fragment.
Plasma and cell-derived fibronectin are potent chemoattractants for human dermal fibroblasts in vitro. The chemotactic property of fibronectin resides in a major 140,000-mol wt non-gelatin-binding fragment of the native molecule. Human monocytes and neutrophils do not recognize fibronectin as a chemotactic stimulus. These findings suggest that fibronectin and perhaps certain fragments of fibronectin may function in vivo as a specific chemoattractant for fibroblasts and could, therefore, induce directional migration of fibroblasts to sites of tissue injury, remodeling or morphogenesis.
D001665:Binding Sites; D002633:Chemotaxis; D002850:Chromatography, Gel; D005347:Fibroblasts / Q000276:immunology; D005353:Fibronectins / Q000097:blood / Q000494:pharmacology*; D005780:Gelatin / Q000494:pharmacology*; D006801:Humans; D008970:Molecular Weight
D005353:Fibronectins; D005780:Gelatin