[Cyclosporin A--effects and side effects in the treatment of rheumatoid and psoriatic arthritis (author's transl)].
The treatment of rheumatoid arthritis and psoriatic arthritis with cyclosporin A is described. Cyslosporin A is a new selective immunosuppressant which acts primarily on the T lymphocytes. It has already been shown to be effective in preventing rejection following kidney transplantation as well as in preventing graft-versus-host disease. In rheumatoid and psoriatic arthritis, however, its effect was not satisfactory, although rather different in the two conditions; overall only about one third of the patients showed any marked improvement. By contrast, and for reasons which are as yet unexplained, it had a beneficial effect on the cutaneous symptoms of psoriasis. Cyclosporin A had little effect on immune parameters. Side effects--mainly kidney toxicity, gastro-intestinal reactions and hirsutism--were common but reversible. On present evidence its principal indication among rheumatological diseases would seem to be as a treatment for severe, intractable psoriatic arthritis.
D000368:Aged; D001168:Arthritis / Q000188:drug therapy* / Q000209:etiology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury; D003524:Cyclosporins; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006628:Hirsutism / Q000139:chemically induced; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000009:adverse effects / Q000627:therapeutic use*; D011565:Psoriasis / Q000150:complications / Q000188:drug therapy
D003524:Cyclosporins; D010456:Peptides, Cyclic
Cyclosporin A--Wirkungen und Nebenwirkungen bei der Behandlung der chronischen Polyarthritis und der Psoriasisarthritis.