The effect of antifibrinolysis on renal stone formation.
The influence of decreased urinary fibrinolysis on renal stone formation was studied in rats fed on a calculus producing diet. The alteration in the isolated glomerular fibrinolytic activity indicating the amount of urokinase produced has also been investigated using a histochemical fibrin slide technique. The glomerular fibrinolytic activity was significantly enhanced by both tranexamic acid and the dietary treatment. The induced antifibrinolysis resulted in a significantly higher incidence of grossly visible calculi in the renal pelvis and in calcified deposits along the cortico-medullary border of the kidney. The results support the concept that a decline in urinary fibrinolytic activity can lead to the formation of renal stones.
D000818:Animals; D004032:Diet; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D007669:Kidney Calculi / Q000209:etiology*; D007678:Kidney Glomerulus / Q000187:drug effects / Q000503:physiopathology; D051381:Rats; D014148:Tranexamic Acid / Q000494:pharmacology
D014148:Tranexamic Acid