title: Trypanotolerance in inbred mice: an immunological basis for variation in susceptibility to infection with Trypanosoma brucei.
abstract: Previous studies have suggested that the suppression of IgM responses induced by different strains of trypanosomes can be related to the virulence of the parasite in a defined mouse strain (Sacks et al. 1980). This study has examined immunosuppression induced by Trypanosoma brucei NIM7 in two mouse strains (C3H/He and [CBA/H x C57B1/6]F1) which differ considerably in their ability to survive infections. The results confirm our previous studies in that mice were able to survive infection whilst they maintained at last a residue of their ability to mount an IgM response to DNP-Ficoll, a T-independent antigen. Complete abrogation of the IgM response coincided with fulminating parasitaemia, resulting in the death of the host.
mesh_terms: D000818:Animals; D005260:Female; D007108:Immune Tolerance; D007075:Immunoglobulin M / Q000276:immunology; D007165:Immunosuppression Therapy; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology*; D013045:Species Specificity; D014346:Trypanosoma brucei brucei / Q000276:immunology; D014353:Trypanosomiasis, African / Q000276:immunology*
chemical_list: D007075:Immunoglobulin M