Management of prolonged therapeutic barbiturate coma.
Barbiturate administration for protection from focal ischemia was evaluated in baboons. All animals were monitored for 96 hours in an intensive care unit during various regimens of pentobarbital administration. Intermittent bolus injections of barbiturate yielded inconsistent electroencephalographic responses and produced the most cardiovascular instability. Continuous barbiturate infusion safely allowed the greatest amount of barbiturate to be employed with the most stable electrophysiological and cardiovascular response.
D000818:Animals; D001463:Barbiturates / Q000008:administration & dosage* / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002545:Brain Ischemia / Q000503:physiopathology* / Q000517:prevention & control; D002302:Cardiac Output / Q000187:drug effects; D003128:Coma / Q000503:physiopathology*; D004569:Electroencephalography; D007263:Infusions, Parenteral; D008297:Male; D010215:Papio
D001463:Barbiturates