Treatment of chronic anovulation and corpus luteum deficiency with epimestrol.
Ten patients presenting with anovulatory syndrome (AS, 4 patients), inadequate luteal phase (ILP, 3 patients) and short luteal phase (SLP, 3 patients) were treated with epimestrol for 29 cycles in total. The initial treatment was always 10 mg/day for 10 days followed by a modification of the daily dose and/or length of treatment needed. Ovulation was induced in all 4 AS patients with an adequate luteal phase (ALP) in 3 of them. In all other patients (with ILP and SLP) an ALP was induced; 2 of them became pregnant. No side-effects were reported.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000858:Anovulation / Q000188:drug therapy*; D002908:Chronic Disease; D003338:Corpus Luteum / Q000502:physiology; D004836:Epimestrol / Q000008:administration & dosage / Q000627:therapeutic use*; D004963:Estrenes / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D010062:Ovulation Induction; D013607:Tablets
D004963:Estrenes; D013607:Tablets; D004836:Epimestrol