Evaluation of anti-inflammatory and analgesic properties of L-glutamine.
It was established that L-glutamine, an aminoacid, has marked anti-inflammatory activity and moderate analgesic activity. The drug was effective orally in suppressing various experimentally induced inflammatory reactions and did not show any gastric irritation in anti-inflammatory doses. It is observed that the anti-inflammatory effect of L-glutamine is not due to counter irritant action. It is suggested that it may partially mediate its anti-inflammatory activity by interfering with the action and/or synthesis of prostaglandins. Its anti-inflammatory activity is comparable to that of phenylbutazone and merits further study.
D000700:Analgesics; D000818:Animals; D000893:Anti-Inflammatory Agents; D003967:Diarrhea / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000188:drug therapy; D005260:Female; D005973:Glutamine / Q000494:pharmacology*; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D010653:Phenylbutazone / Q000494:pharmacology; D011448:Prostaglandin Antagonists / Q000008:administration & dosage; D051381:Rats; D013997:Time Factors
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D011448:Prostaglandin Antagonists; D005973:Glutamine; D010653:Phenylbutazone