[Effect of cicloxilic acid on biliary dynamics].
This work was developed in order to estimate, with objective methods, the pharmacodynamic activities of a new choleretic and antilithogenic drug, the cicloxilic acid. It was determined the changes of daily biliary flow and bile composition in 8 patients with biliary system surgical intervention and "T" (Kehr) tube inserted. The cicloxilic acid was given in the dose of 240 mg/day. The results showed, after treatment, an emphasized middle volume increase of the excreted bile, as well as a significant decrease of the biliary cholesterol, while pH and density maintained constants. The results corroborated the pharmacodynamic activities given to cicloxilic acid as a "true" choleretic to be utilized in clinic situations where it's wished a biliary flow increase and the possibility to avoid a cholesterol lithiasis or relieve consequent disturbances.
D000368:Aged; D001646:Bile / Q000187:drug effects* / Q000378:metabolism; D002769:Cholelithiasis / Q000517:prevention & control; D002784:Cholesterol / Q000378:metabolism*; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged
D003509:Cyclohexanecarboxylic Acids; C018873:cicloxilic acid; D002784:Cholesterol
Ação do ácido cicloxílico sobre a dinâmica biliar.