title: 17-Ketosteroids via a base induced cleavage of C-17-dihydroxy acetone side chains.
abstract: A new, base-catalyzed cleavage of C21-steroids to give 17-ketosteroids is described. This reaction is specific for those steroids containing the C-17-dihydroxy acetone side chain. In the presence of oxygen, these same reaction conditions readily degrade corticosterone to the 17 beta-carboxylic acid.
mesh_terms: D015068:17-Ketosteroids / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D013058:Mass Spectrometry; D008722:Methods; D013329:Structure-Activity Relationship
chemical_list: D015068:17-Ketosteroids