Radioimmunolocalization of tumours by external scintigraphy after administration of 131I antibody to human chorionic gonadotrophin: preliminary communication.
(131)Iodine ((131)I) labelled antibody directed against human chorionic gonadatrophin (hCG) was given on 21 occasions to 18 patients with hCG-producing neoplasms. Tumours were localized by external scintigraphy in 13 of 21 investigations. Positive results were obtained reliably when serum hCG exceeded 500 miu/ml and in some cases sensitivity was comparable to that of computerized tomography. A positive result probably implies viability in the tumour and this was of practical value in discriminating between necrotic deposits and living tumour before surgery.
D000906:Antibodies / Q000032:analysis*; D002822:Choriocarcinoma / Q000000981:diagnostic imaging* / Q000378:metabolism; D006063:Chorionic Gonadotropin / Q000032:analysis / Q000276:immunology*; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000000981:diagnostic imaging* / Q000378:metabolism; D007457:Iodine Radioisotopes; D011247:Pregnancy; D011863:Radioimmunoassay; D011877:Radionuclide Imaging; D013724:Teratoma / Q000000981:diagnostic imaging* / Q000378:metabolism; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism
D000906:Antibodies; D006063:Chorionic Gonadotropin; D007457:Iodine Radioisotopes