Tryptophan metabolism in children with attentional deficit disorder.
The authors present the first report, to their knowledge, of hyperserotonemia in children with attentional deficit disorder who had normal intelligence. Hyperserotonemic children had significantly lower levels of plasma total and protein-bound tryptophan and a higher percentage of free tryptophan than those with normal serotonin levels. Plasma kynurenine did not differ, suggesting that the hyperserotonemia is not due to a blockade of the kynurenine pathway but may reflect on increase in tissue tryptophan uptake and use.
D000293:Adolescent; D000328:Adult; D001288:Attention / Q000502:physiology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003913:Dextroamphetamine / Q000627:therapeutic use; D006801:Humans; D007360:Intelligence; D007737:Kynurenine / Q000097:blood; D008774:Methylphenidate / Q000627:therapeutic use; D011485:Protein Binding; D012701:Serotonin / Q000097:blood; D014364:Tryptophan / Q000097:blood*
D008774:Methylphenidate; D012701:Serotonin; D007737:Kynurenine; D014364:Tryptophan; D003913:Dextroamphetamine