Effects of four bisphenolic antioxidants on lipid contents of rat liver.
Hepatic lipids were studied in Sprague-Dawley male rats given, 2,2'-methylenebis(4-ethyl-6-tert-butylphenol), 2,2'-methylenebis(4-methyl-6-tert-butylphenol), 4,4'-butylidenebis(3-methyl-6-tert-butylphenol) or 4,4'-methylenebis(2,6-di-tert-butylphenol) at a level of 1.135 mmol% for 1 week. 4,4'-Butylidenebis(3-methyl-6-tert-butylphenol) induced fatty liver and increased triglyceride, diglyceride and cholesteryl-ester concentrations, 7.1-, 5.8- and 6.1-fold, respectively. Plasma triglycerides, total cholesterol and non-esterified fatty acids were markedly decreased. It would appear that the fatty liver resulted mainly from defective fat excretion from the liver. The other bisphenols produced a little change in liver lipids.
D000818:Animals; D000975:Antioxidants / Q000506:poisoning*; D002084:Butylated Hydroxytoluene / Q000031:analogs & derivatives* / Q000506:poisoning; D005234:Fatty Liver / Q000139:chemically induced; D008055:Lipids / Q000032:analysis*; D008099:Liver / Q000032:analysis / Q000187:drug effects*; D008297:Male; D051381:Rats
D000975:Antioxidants; D008055:Lipids; D002084:Butylated Hydroxytoluene; C030593:4,4'-methylenebis(2,6-di-tert-butylphenol); C030594:Santowhite powder; C008437:2,2'-methylenebis(4-methyl-6-tert-butylphenol); C030577:2,2'-methylenebis(ethyl-6-tert-butylphenol)