Genetic toxicological of some plant flavonoids by the micronucleus test.
4 important flavonoid compounds, namely quercetin, kaempferol, neohesperidin dihydrochalcone and rutin, were administered to male mice for the detection of gross chromosomal anomalies by the micronucleus test. The first 3 compounds were positively clastogenic to different extents, whereas the 4th was negative.
D000818:Animals; D001854:Bone Marrow Cells; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D002599:Chalcone / Q000031:analogs & derivatives / Q000494:pharmacology; D047188:Chalcones; D004912:Erythrocytes / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D006569:Hesperidin / Q000031:analogs & derivatives / Q000494:pharmacology; D044949:Kaempferols; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D010944:Plants; D011794:Quercetin / Q000494:pharmacology; D012431:Rutin / Q000494:pharmacology; D013549:Sweetening Agents / Q000494:pharmacology
D047188:Chalcones; D005419:Flavonoids; D044949:Kaempferols; D009153:Mutagens; D013549:Sweetening Agents; C013613:neohesperidin dihydrochalcone; D012431:Rutin; D002599:Chalcone; C006552:kaempferol; D011794:Quercetin; D006569:Hesperidin