[Effect of adrenaline, noradrenaline and acetylcholine on rabbit and human uterine activity in vivo (author's transl)].
Effects of estrogen (abbr. as E), Estrogen + Progesterone (E + P) and autonomic nerve trophic drugs on uterus were investigated in rabbit and human in vivo and the following results were obtained. 1) Spontaneous contraction in cornu and cervix of E treated rabbit were stronger than in those during pregnancy or treated with E + P. 2) 10(-5) g/kg Adrenaline caused a uniform response pattern in cornu and cervix of E treated rabbit, and the pattern could be divided into three phases. Phase I is supposed to be the contraction response through the alpha receptor, and phase II is presumed as the response that comprises a part of element identical with alpha adrenergic response, while phase III is the relaxation response through the beta 2 receptor. 3) Acetylcholine (ACh) 10(-3) g/kg and Neostigmine 10(-5) g/kg caused augmentation of contraction both in cornu and cervix of rabbit, but this effect was blocked by Atropine, suggesting the presence of parasympathetic control in cornu and cervix. 4) In human corpus and cervix, Phenylephrine and ACh augmented contraction but Terbutaline had reducing contraction, showing the similar phenomenon found in rabbit. From this, it was proven that the similar autonomic nerve controls could be present both in rabbit and human.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D004837:Epinephrine / Q000494:pharmacology*; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D006801:Humans; D009638:Norepinephrine / Q000494:pharmacology*; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology; D011817:Rabbits; D013566:Sympathomimetics / Q000494:pharmacology; D014590:Uterine Contraction / Q000187:drug effects*
D004967:Estrogens; D013566:Sympathomimetics; D011374:Progesterone; D000109:Acetylcholine; D009638:Norepinephrine; D004837:Epinephrine