Effect of changing potassium ion concentrations on rat cerebral slices in vitro: a study during development.
Adult rat cerebral cortex slices when incubated in media in increasing K+ concentrations, from 3 to 20 mM ("physiological" conditions), exhibited an increase of Ki+ and a decrease of Nai+ and Cli-. This phenomenon appeared at 30 days postnatally, which is fairly late during development. Over 20 mM-K+ ("pathological" conditions) an intense water uptake was observed together with an increase of Nai+ and Cli-. This was observed in both adult and young animals. The results are discussed in relation to the well known properties of glial (Na+,K+)-ATPase and carbonic anhydrase.
D000818:Animals; D002414:Cations, Monovalent; D002540:Cerebral Cortex / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D012964:Sodium / Q000378:metabolism; D014867:Water / Q000378:metabolism
D002414:Cations, Monovalent; D002712:Chlorides; D014867:Water; D012964:Sodium; D011188:Potassium