Distribution of IgE in a community population sample: correlations with age, sex, and allergen skin test reactivity.
The distribution of total serum IgE determined by the paper radioimmunosorbent test (PRIST) is examined in a large random stratified community population. Prior to logarithmic conversion the distribution of this immunoglobulin is not normal, with almost 40% of values below 20 IU/ml. A normal distribution occurs following such conversion, with a geometric mean value of 32.1 IU/ml. Both age and sex, in addition to atopic status, relate to IgE level. In both sexes highest levels occur among 6- to 14-year-olds, and males have higher levels than females at any given age. Women over age 75 yr have the lowest levels (geometric mean 9.2 IU/ml). Subjects with positive skin test results have several times the concentration of IgE as their nonatopic counterparts.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens; D001130:Arizona; D002648:Child; D005260:Female; D006801:Humans; D007073:Immunoglobulin E; D008297:Male; D008875:Middle Aged; D011153:Population; D011864:Radioimmunosorbent Test; D012882:Skin Tests
D000485:Allergens; D007073:Immunoglobulin E