title: [Cytochrome P-450 distribution in endoplasmic reticulum membranes of rat liver].
abstract: Using electron-dense labelling in combination with solubilization, the localization of cytochrome P-450 in the microsomal membranes was studied. It was shown that cytochrome P-450 is unevenly distributed in the membrane and has 2-3 reactive SH-groups. The molecules of solubilized cytochrome P-450 contain 4-5 reactive SH-groups and show a tendency to aggregate. A comparative study of cytochrome P-450 distribution in the microsomal ghosts membranes in proteoliposomes was carried out.
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis*; D004721:Endoplasmic Reticulum / Q000378:metabolism* / Q000648:ultrastructure; D005260:Female; D007425:Intracellular Membranes / Q000378:metabolism* / Q000648:ultrastructure; D008099:Liver / Q000378:metabolism; D046911:Macromolecular Substances; D008862:Microsomes, Liver / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats
chemical_list: D046911:Macromolecular Substances; D003577:Cytochrome P-450 Enzyme System
vernacular_title: Izuchenie raspredeleniia tsitokhroma P-450 v membranakh endoplazmaticheskogo retikuluma pecheni krysy.