The effect of a test meal on plasma gastric inhibitory polypeptide and serum gastrin in patients with achlorhydria and hypergastrinemia, and in patients with normal gastric H+ secretion.
9 patients with achlorhydria and hypergastrinemia and 8 control patients with normal gastric H+ secretion and normal serum gastrin level were studied before and after a mixed liquid test meal. Mean plasma gastric inhibitory polypeptide increased to significantly higher values in the achlorhydric group than in the control group 30, 60 and 90 min after the meal. In the achlorhydric group mean serum gastrin fell significantly below the basal level 60 and 90 min after the meal, whereas a significant increase was observed in the control group.
D000126:Achlorhydria / Q000097:blood*; D000328:Adult; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D005749:Gastric Inhibitory Polypeptide / Q000097:blood*; D005750:Gastric Juice / Q000378:metabolism; D005755:Gastrins / Q000097:blood*; D005768:Gastrointestinal Hormones / Q000097:blood*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D005755:Gastrins; D005768:Gastrointestinal Hormones; D005749:Gastric Inhibitory Polypeptide