Urease inhibitor therapy in infected renal stones.
The strict dependence of struvite and carbonate apatite renal stones on the urease-producing germs confirm the need to combine bacterial urease inhibitor drugs with antibiotic treatment. Of the two antiurease drugs used the better results were obtained with acetohydroxamic acid, both for its minimum side effects and its more powerful urease-inhibitor capacity. Thus stone recurrence was avoided even in patients with urinary infection not responding to specific antibiotic treatment.
D000293:Adolescent; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D049669:History, 16th Century; D006801:Humans; D006877:Hydroxamic Acids / Q000008:administration & dosage*; D006918:Hydroxyurea / Q000008:administration & dosage*; D007669:Kidney Calculi / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000209:etiology
D000892:Anti-Infective Agents, Urinary; D006877:Hydroxamic Acids; C006358:acetohydroxamic acid; D006918:Hydroxyurea