title: Diethyl ether influence on the metabolism of antipyrine, paracetamol and sulphanilamide in isolated rat hepatocytes.
abstract: Drug metabolism was studied in suspensions of isolated rat liver parenchymal cells. The influence of diethyl ether 2.5-30 mmol litre-1 on metabolism of antipyrine, paracetamol and sulphanilamide was studied. A dose-related ether inhibition of antipyrine and paracetamol metabolism was found. Fifty per cent inhibition of antipyrine metabolism occurred at ether concentrations between 2.5 and 5 mmol litre-1 while 50% inhibition of paracetamol metabolism was found at greater ether concentrations (20-30 mmol litre-1). No ether inhibition of sulphanilamide metabolism was demonstrated. It is concluded that different degrees of ether interaction have to be considered for the various hepatic pathways of drug metabolism.
mesh_terms: D000082:Acetaminophen / Q000378:metabolism*; D000818:Animals; D000983:Antipyrine / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects; D004986:Ether / Q000494:pharmacology*; D005019:Ethyl Ethers / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D013424:Sulfanilamides / Q000378:metabolism*
chemical_list: D005019:Ethyl Ethers; D013424:Sulfanilamides; D004986:Ether; D000082:Acetaminophen; D000983:Antipyrine