Morphological changes after treatment of bovine cysticercosis with droncit and oxichloron.
Droncit and Oxichloron in total doses of 100 (50 mg/kg for two days) and 300 mg/kg (100 mg/kg for three days) of body weight were applied for the treatment of cysticercosis 12 (Droncit) and 6 (Oxichloron) weeks after experimental infection. Four or six weeks after the treatment dead cysticerci or their remnants were found. There occurred a striking vacuolization of the larval tegument, but even six weeks after the treatment, muscles, portions of subtegumental cells and remnants of excretory canalicular system and microtriches were discernible. The structure of microtriches was still well preserved in some cases. The dominating component of tissue reaction around the dead larvae was the hyperplasia of lymphoid tissue forming sometimes folliculoid structures, and blastic transformation of lymphocytes. Nodules with dead larvae were separated from the surrounding tissue by connective tissue.
D000818:Animals; D000923:Anticestodal Agents / Q000627:therapeutic use*; D001735:Bithionol / Q000031:analogs & derivatives / Q000627:therapeutic use; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000469:parasitology; D003551:Cysticercosis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D003552:Cysticercus / Q000033:anatomy & histology / Q000187:drug effects*; D007546:Isoquinolines / Q000627:therapeutic use*; D008213:Lymphocyte Activation; D008264:Macrophages; D011223:Praziquantel / Q000627:therapeutic use*; D013621:Taenia / Q000187:drug effects*
D000923:Anticestodal Agents; D007546:Isoquinolines; C030608:oxichloron; D011223:Praziquantel; D001735:Bithionol