Calcium and monoamine regulation: role of vitamin D nutrition.
The mechanism of vitamin D participation in the processes of monoamine regulation was studied. Central and peripheral endogenous norepinephrine levels were compared in vitamin D deficient rats, in preventative vitamin D3 (1 IU/day) administered rats, and in lactose (20% of the diet) administered rats, lactose being known to increase intestinal absorption of calcium. Vitamin D deficiency resulted in a significant decrease in endogenous norepinephrine. The decrease was of variable magnitude according to the considered organs. The adrenal dopamine level was also less in vitamin D deficient rats than in rats given vitamin D in preventive treatment. However, it remained in the brain. In the absence of vitamin D dietary lactose restored blood calcium and endogenous norepinephrine levels in all the tissues, except in the liver. It appears that the decrease in norepinephrine storage in vitamin D deficient rats resulted from a lack of calcium rather than from the absence of vitamin D.
D000311:Adrenal Glands / Q000032:analysis; D000818:Animals; D001923:Brain Chemistry; D002118:Calcium / Q000502:physiology*; D002395:Catecholamines / Q000378:metabolism*; D004298:Dopamine / Q000032:analysis; D007785:Lactose / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D014807:Vitamin D / Q000502:physiology*; D014808:Vitamin D Deficiency / Q000378:metabolism
D002395:Catecholamines; D014807:Vitamin D; D007785:Lactose; D002118:Calcium; D004298:Dopamine; D009638:Norepinephrine