title: Postirradiation recovery of hemopoiesis in mice treated with Propionibacterium granulosum.
abstract: The effect of Propionibacterium granulosum on spontaneous regeneration of hemopoiesis in nonlethally (250 or 400 rads) irradiated mice was investigated and measured by peripheral blood leukocyte counts each 2 days after irradiation and incorporation of 3H-thymidine into spleen and thymus in vivo. P. granulosum injected intraperitoneally in a dose of 1.5 mg per mouse, 7 days before or 4 days after irradiation, resulted in accelerated recovery of hemopoiesis after nonlethal irradiation with significantly higher leukocytosis, as compared with a control non-treated with bacteria. This was accompanied by elevated spleen and thymus weight and higher incorporation of 3 H-thymidine into spleen cells.
mesh_terms: D000818:Animals; D002455:Cell Division; D004731:Endotoxins / Q000494:pharmacology*; D006410:Hematopoiesis / Q000528:radiation effects*; D008297:Male; D051379:Mice; D009929:Organ Size; D011424:Propionibacterium; D013154:Spleen / Q000166:cytology; D013950:Thymus Gland / Q000166:cytology
chemical_list: D004731:Endotoxins