title: Probability of neuronal spike initiation as a curve-crossing problem for Gaussian stochastic processes.
abstract: Probability of neuronal spike initiation was considered within the framework of a simple stochastic model. The time of spike occurrence was defined as the first time of crossing of a stochastic process and a determined time function. This problem has been investigated in the case of a stationary Gaussian stochastic process and a linear time function. An integral equation obtained for the probability density function of the first time crossing was numerically solved by means of computer calculations. The model was applied to the analysis of temporal pattern of spike activity evoked in the cat spinal motoneurones by depolarizing current injected through the recording microelectrode.
mesh_terms: D000818:Animals; D002415:Cats; D005071:Evoked Potentials; D008161:Lumbosacral Region / Q000294:innervation; D008433:Mathematics; D008959:Models, Neurological; D009046:Motor Neurons / Q000502:physiology*; D011336:Probability; D013269:Stochastic Processes