Pharmacokinetic investigations of Craviten. III. Tissue distribution and elimination in rats.
Craviten was given iv in four different doses into male Wistar rats and tissue concentration of that drug was determined. Interpretation of experimental data suggests that the dose dependent pharmacokinetics of Craviten is not related to nonlinear tissue distribution.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D005029:Ethylenediamines / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D013154:Spleen / Q000378:metabolism
D000889:Anti-Arrhythmia Agents; D005029:Ethylenediamines; C030706:butobendin