title: Alterations in human erythrocyte shape and the state of spectrin and phospholipid phosphorylation induced by cholesterol depletion.
abstract: Cholesterol depletion of erythrocytes, obtained after incubation with phosphatidylcholine vesicles, induces in most of the experiments: (1) a discocytestomatocyte transformation as observed by scanning electron microscopy; (2) a specific decrease in spectrin phosphorylation of intact erythrocytes; (3) an increase in lipid phosphorylation. It is concluded that the effect of cholesterol on erythrocyte shape is probably mediated through its action on the activity o of membrane-bound enzymes, proteases or kinases.
mesh_terms: D002784:Cholesterol / Q000097:blood*; D004912:Erythrocytes / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000097:blood / Q000378:metabolism*; D008855:Microscopy, Electron, Scanning; D010743:Phospholipids / Q000097:blood*; D010766:Phosphorylation; D013049:Spectrin / Q000378:metabolism*
chemical_list: D008565:Membrane Proteins; D010743:Phospholipids; D013049:Spectrin; D002784:Cholesterol