title: Lysosomal cathepsin B: correlation with metastatic potential.
abstract: Although lysosomal enzymes are implicated in the processes of tumor invasion and metastasis, their cellular origin within the tumor is unclear. The activity of the lysosomal proteinase cathepsin B is significantly elevated in a variant of the B16 melanoma with high metastatic potential. The cathepsin B activity is localized to the lysosomes of the tumor cells.
mesh_terms: D000818:Animals; D002401:Cathepsin B; D002403:Cathepsins / Q000378:metabolism*; D014644:Genetic Variation; D006867:Hydrolases / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology*; D008545:Melanoma / Q000503:physiopathology*; D051379:Mice; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D009374:Neoplasms, Experimental / Q000503:physiopathology; D013347:Subcellular Fractions / Q000201:enzymology
chemical_list: D006867:Hydrolases; D002403:Cathepsins; D002401:Cathepsin B