Histamine H1- and H2-receptors in the gastric vasculature of the rabbit.
The histamine receptors in the rabbit blood perfused gastric vasculature were analysed pharmacologically. Histamine elicited a monophasic increase in perfusion pressure which was antagonized by mepyramine and enhanced by metiamide. The maximum observed response was enhanced by metiamide to that produced by a specific H1-receptor agonist. It is concluded that the gastric vasculature responds to histamine with an H1-receptor mediated vasoconstriction and an H2-receptor mediated dilatation. In this preparation the H1-effect predominates in response to injection of histamine.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000494:pharmacology; D008297:Male; D011817:Rabbits; D011968:Receptors, Histamine / Q000187:drug effects*; D011969:Receptors, Histamine H1 / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects*; D013270:Stomach / Q000098:blood supply*; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D006632:Histamine