title: Sister chromatid exchange in aged human lymphocytes. A brief note.
abstract: A study of the sister chromatid exchange (SCE) frequency in peripheral lymphocytes from 26 human subjects, with in vivo age of the cells as the variable, demonstrated a significant increase in SCE frequency with increasing age of the subject (analysis of variance: p less than 0.01). The cells were cultured in Eagles' basal medium with 5-bromodeoxyuridine added to a final concentration of 10  microM. These results are contradictive to the brunt of the literature which indicates that background SCE frequency does not change with age.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002470:Cell Survival; D002648:Child; D002675:Child, Preschool; D003434:Crossing Over, Genetic; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008214:Lymphocytes / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D012854:Sister Chromatid Exchange