[Metabolism of 32P-butonate and formation of vinylbutonate metabolite in warm-blooded animals].
The metabolic fate of butonate, a 32P-labelled organophosphorus insecticide (0.0-dimethyl-l-n-butyryloxy-2.2.2-trichloro-ethyl phosphonate) was investigated in blood serum of cattle in vitro and in mice in vivo, following intraperitoneal and oral administration of 200 mg/kg. Metabolites were separates by thin-layer chromatography, using two solvent systems, acetonitrile-water = 85:15 and ethyl ether, for polar or non-polar metabolites. The Rf-values as well as the partition coefficients for chloroform and water and ethyl ether to ten per cent H2SO4 and for n-hexane and acetonitrile are given for butonate and the metabolites together with the amounts of metabolite, following in vivo metabolic degradation. The blood level as well as residues in milk are given by the following graduation: trichlorphone greater than vinylbutonate greater than butonate greater than dichlorvos. The formation of the new metabolite vinylbutonate is discussed.
D000818:Animals; D002417:Cattle; D002855:Chromatography, Thin Layer; D003640:Dealkylation; D004006:Dichlorvos / Q000097:blood / Q000378:metabolism; D005260:Female; D008297:Male; D051379:Mice; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000097:blood / Q000378:metabolism*; D010761:Phosphorus Radioisotopes; D014236:Trichlorfon / Q000097:blood / Q000378:metabolism
D063065:Organophosphonates; D009943:Organophosphorus Compounds; D010761:Phosphorus Radioisotopes; C006845:butonate; C028080:vinylbutonate; D004006:Dichlorvos; D014236:Trichlorfon
Zum Metabolismus von 32P-Butonat und zur Bildung des Metaboliten Vinylbutonat im Warmblüter.