Bile acid kinetics, steroid balance and biliary lipids in hyperlipoproteinaemia type III.
Bile acid kinetics, steroid balance and biliary lipid composition were studied in 8 patients with hyperlipoproteinaemia (HLP) type III (broad-beta-disease). As a general finding the formation of bile acids exceeded the range encountered in normolipidaemic subjects, but the mean net steroid balance remained normal. On the basis of previous findings of a close correlation between the synthesis of VLDL-triglycerides and bile acids in other types of HPL it is suggested that HPL type III may be associated with an enhanced VLDL production. As a further indication of a disturbed cholesterol metabolism the bile was supersaturated with cholesterol in al subjects.
D000328:Adult; D000368:Aged; D001646:Bile / Q000032:analysis*; D001647:Bile Acids and Salts / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II; D006952:Hyperlipoproteinemia Type III / Q000378:metabolism; D006953:Hyperlipoproteinemia Type IV / Q000378:metabolism; D050356:Lipid Metabolism; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D013256:Steroids / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
D001647:Bile Acids and Salts; D008079:Lipoproteins, VLDL; D013256:Steroids; D014280:Triglycerides; D002784:Cholesterol