Interactions between oligonucleotides having a left-handed helical structure and ethidium bromide.
Oligonucleotides containing a 8,2'-S-cycloadenosine(As), 8,2'-S-cycloinosine(Is), 6,2'-O-cyclouridine(Uo) and 6,2'-O-cyclocytidine(Co) residues, which have a glycosidic torsion angle(chi) of about 120 degrees, were synthesized. Among these oligomers, AspUo, AspIs and (pCo)4 + (pIs)4 formed a complex with ethidium bromide, which was assumed to be intercalated between the adjacent base-pairs of the left-handed double helix.
D055598:Chemical Phenomena; D002621:Chemistry; D002942:Circular Dichroism; D004996:Ethidium; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides; D009843:Oligoribonucleotides; D013329:Structure-Activity Relationship
D009841:Oligonucleotides; D009843:Oligoribonucleotides; D004996:Ethidium