Copper deficiency suppresses the immune response of mice.
Mice fed a purified diet low in copper display anemia, hypoceruloplasminemia, depressed concentrations of liver copper, and elevated concentrations of liver iron. An impaired humoral-mediated immune response (decreased numbers of antibody-producing cells) is observed in mice with severe as well as marginal copper deficiency. The magnitude of this impairment is highly correlated with the degree of functional copper deficiency (hypoceruloplasminemia).
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D002570:Ceruloplasmin / Q000378:metabolism; D003300:Copper / Q000172:deficiency* / Q000494:pharmacology; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D012737:Sex Factors; D013154:Spleen / Q000187:drug effects
D006454:Hemoglobins; D003300:Copper; D007501:Iron; D002570:Ceruloplasmin