Irreversible inactivation of delta 5-3-ketosteroid isomerase of Pseudomonas testosteroni by acetylenic suicide substrates. Mechanism of formation and properties of the steroid-enzyme adduct.
D001665:Binding Sites; D004963:Estrenes / Q000494:pharmacology*; D007535:Isomerases / Q000037:antagonists & inhibitors*; D007700:Kinetics; D008433:Mathematics; D009652:Norpregnenes / Q000494:pharmacology*; D011485:Protein Binding; D011549:Pseudomonas / Q000201:enzymology*; D012632:Secosteroids / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013251:Steroid Isomerases / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D004963:Estrenes; D009652:Norpregnenes; D012632:Secosteroids; C024783:5,10-secoestr-5-yne-3,10,17-trione; C030828:5,10-seco-19-norpregn-5-yne-3,10,20-trione; D007535:Isomerases; D013251:Steroid Isomerases; C022660:steroid delta-isomerase