title: CSF perfusion to treat intraventricular penicillin toxicity.
abstract: A shunt infection and meningitis developed in a patient receiving methotrexate intravenously for CNS leukemia. Convulsions and respiratory failure followed the intraventricular administration of 300,000 units of penicillin G potassium. Perfusion with 900 mL of Ringer's lactate removed an amount of penicillin equal to that injected intraventricularly plus some from systemic treatment.
mesh_terms: D000328:Adult; D002555:Cerebrospinal Fluid; D006801:Humans; D007276:Injections, Intraventricular; D007938:Leukemia / Q000150:complications; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications; D008581:Meningitis / Q000188:drug therapy; D010400:Penicillin G / Q000633:toxicity*; D010477:Perfusion
chemical_list: D010400:Penicillin G