[Effect of carbostimulin on metabolism in rats with deep burns].
It is established that at early stages of the burn disease (deep burn of III-B degree, 20% of body surface) in rats there appears metabolic acidosis, the content of urea increases in the liver and blood serum, a pronounced hydration of the liver and muscles is observed in the burn zone. Administration per os of carbostimulin just a day after burn removes symptoms of metabolic acidosis. When the preparation is fed to rats during 7 days after burn the intensity of radioactive label incorporation into proteins, lipid and glycogen of the liver as well as in proteins and lipids of kidneys and spleen increases.
D000138:Acidosis / Q000188:drug therapy / Q000209:etiology; D000818:Animals; D002056:Burns / Q000378:metabolism*; D002254:Carbonates / Q000378:metabolism* / Q000627:therapeutic use; D004338:Drug Combinations / Q000378:metabolism / Q000627:therapeutic use; D008055:Lipids / Q000096:biosynthesis; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008112:Liver Glycogen / Q000096:biosynthesis; D008278:Magnesium Sulfate / Q000378:metabolism* / Q000627:therapeutic use; D008297:Male; D008345:Manganese / Q000378:metabolism* / Q000627:therapeutic use; D017895:Manganese Compounds; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D014176:Protein Biosynthesis; D051381:Rats; D013154:Spleen / Q000378:metabolism; D014508:Urea / Q000378:metabolism; D015032:Zinc / Q000378:metabolism* / Q000627:therapeutic use; D017967:Zinc Compounds
D002254:Carbonates; D004338:Drug Combinations; D008055:Lipids; D008112:Liver Glycogen; D017895:Manganese Compounds; D017967:Zinc Compounds; D008345:Manganese; C021160:Carbostimulin; D008278:Magnesium Sulfate; D014508:Urea; D015032:Zinc
Vliianie karbostimulina na obmen veshchestv u krys pri ozhogovoĭ bolezni.