Vitamin C acts as a cocarcinogen to methylcholanthrene in guinea-pigs.
Large doses of vitamin C were found to promote the induction of sarcomas by methylcholanthrene. The tumours appeared earlier in the group of guinea-pigs treated with vitamin C after injection of methylcholanthrene than in the control group injected with methylcholanthrene. The treatment of guinea-pigs with vitamin C after induction of tumours thus did not inhibit the growth of tumours.
D000818:Animals; D001205:Ascorbic Acid / Q000633:toxicity*; D006168:Guinea Pigs; D008748:Methylcholanthrene; D009374:Neoplasms, Experimental / Q000139:chemically induced*
D008748:Methylcholanthrene; D001205:Ascorbic Acid