[Pathogenetic role of lipid peroxidation and the protective role of sodium selenite in ischemia and myocardial reperfusion].
The data obtained in experiments on 89 random bred male white rats indicate an important pathogenetic role of lipid peroxidation activation during ischemia of the myocardium and its further reperfusion. Inhibition of lipid peroxidation by sodium selenite was accompanied by increased resistance of the heart to its reversible ischemia. The evidence obtained documents a new principle of pathogenetic therapy of transitory coronary insufficiency with lipid peroxidation inhibitors, particularly sodium selenite. The data presented may be of importance for clinical practice since transitory myocardial ischemia in animals represents an experimental model of the forms of coronary heart disease of man which are accompanied by transient reduction of the coronary blood flow.
D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008297:Male; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D020887:Selenious Acid; D012643:Selenium / Q000627:therapeutic use*
D008054:Lipid Peroxides; D020887:Selenious Acid; D012643:Selenium
Patogeneticheskaia rol' aktivnatsii perekisnogo okisleniia lipidov i protektivnyĭ éffekt selenita natriia pri ishemii i reperfuzii miokarda.