Further studies on oligoribonucleotide synthesis.
Recent results concerning the synthesis of oligoribonucleotides via the phosphotriester method, such as functionalization of ribonucleosides, new phosphorylating agents, 5'-O-sulfonylation and chromatography on Sephadex LH-20 for monitoring the removal of internucleotide phosphotriester groups, are presented. To show that efficiency of a new approach to the synthesis of oligoribonucleotides the pentamer /Up/4U was obtained.
D004952:Esters; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D009841:Oligonucleotides / Q000138:chemical synthesis*; D009843:Oligoribonucleotides / Q000138:chemical synthesis*; D012833:Siloxanes
D004952:Esters; D007202:Indicators and Reagents; D009841:Oligonucleotides; D009843:Oligoribonucleotides; D012833:Siloxanes; C031036:1,3-dichlorotetraisopropyldisiloxane