Biosynthetic pathway of 2-deoxystreptamine.
Four 2-deoxystreptamine (DOS) related compounds including S-11-P, isolated as an intermediate of DOS biosynthesis, were supplemented to the culture of a DOS- mutant of Bacillus circulans. Among the tested aminocyclitol compounds, S-11-P alone was converted to DOS. Addition of other aminocyclitols neither produced antibiotic nor inhibited the incorporation of S-11-P and DOS into butirosins. By these facts, S-11-P was confirmed clearly to be an intermediate of DOS biosynthesis.
D001407:Bacillus / Q000378:metabolism; D006595:Hexosamines / Q000096:biosynthesis* / Q000378:metabolism; D009154:Mutation
D006595:Hexosamines; C027405:3-amino-2,3-dideoxyinositol; C007265:2-deoxystreptamine