Rapid-eye-movement sleep deprivation inhibits clonidine-induced sedation in rats.
The effects of 24 and 48 h of rapid-eye-movement sleep deprivation (REMD) on clonidine-induced sedation and [3H]clonidine binding to cortical membranes were studied in rats. REMD did not affect the exploratory behaviour (ambulation, rearing + peeping) of normal rats. The sedative effect of clonidine (0.2 mg/kg s.c.) on the rearing + peeping behaviour of rats was inhibited by REMD. [3H]Clonidine binding in the cerebral frontal cortex remained unaffected. The results are discussed in terms of changes in the noradrenergic system.
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D003000:Clonidine / Q000378:metabolism / Q000494:pharmacology*; D006993:Hypnotics and Sedatives; D008297:Male; D051381:Rats; D012892:Sleep Deprivation; D012895:Sleep, REM
D006993:Hypnotics and Sedatives; D003000:Clonidine