[Cerebral and hepatic arginase and polyamines in the mechanisms of the protective effect of arginine in hyperoxia].
The effect of protective concentrations of arginine on the arginase activity and the content of rat brain and liver spermidine and spermine was studied under hyperoxia (6 atmospheres). Intraperitoneal injection of arginine to intact animals increases the arginase activity and the brain content of spermidine and spermine by 15, 19 and 25%, respectively. The liver arginase activity rises by 55%, while the level of the polyamines remains almost unchanged. Arginine injection before hyperoxic exposure prevents the significant lowering of the arginase activity and polyamine content seen in the unprotected animals. The relationship between the arginase activity and the polyamine level in the brain and liver is discussed with emphasis on arginine efficacy as protective agent in hyperoxia.
D000818:Animals; D001119:Arginase / Q000378:metabolism*; D001120:Arginine / Q000627:therapeutic use*; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D008099:Liver / Q000032:analysis / Q000378:metabolism*; D008297:Male; D010100:Oxygen / Q000506:poisoning*; D011073:Polyamines / Q000032:analysis*; D051381:Rats; D013095:Spermidine / Q000032:analysis; D013096:Spermine / Q000032:analysis
D011073:Polyamines; D013096:Spermine; D001120:Arginine; D001119:Arginase; D010100:Oxygen; D013095:Spermidine
Arginaza i poliaminy mozga i pecheni v mekhanizme zashchitnogo deĭstviia arginina pri giperoksii.