Central action of mepiprazole.
Mepiprazole, a phenylpiperazine derivative, strongly antagonizes the behavioral syndromes evolved by 5-hydroxytrypotophan. The drug did not affect the serotonin neurons in the preparation of flexor reflex of the hind paw of the spinal rat: in higher doses it depressed the reflex showing noradrenolytic properties. Mepiprazole antagonized the fenfluramine-induced hyperthermia, depressed spontaneous locomotor activity, produce hypothermia and was inactive in the despair test. The results suggest that mepiprazol may have noradenolytic properties; its possible influence on the serotonergic system is masked by noradrenolytic properties and hence difficult to demonstrate.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D007103:Immobilization / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects*; D012018:Reflex / Q000187:drug effects; D014149:Tranquilizing Agents / Q000494:pharmacology*; D014196:Trazodone / Q000378:metabolism
D010879:Piperazines; D011720:Pyrazoles; D011941:Receptors, Adrenergic; D011985:Receptors, Serotonin; D014149:Tranquilizing Agents; C008351:mepiprazole; D014196:Trazodone