[Stimulation of desoxyribonuclease activity by nitrosomethylurea].
It is shown in vitro in model experiments under biological conditions of pH and temperature, the pancreatic DNase activation by nitrosomethylurea depends on both mutagen concentration and temperature. The spectrophotometric observation revealed the formation of mutagen-enzyme complex which resulted from the interaction of the mutagen molecules with DNase macromolecules.
D000818:Animals; D003851:Deoxyribonucleases / Q000378:metabolism*; D004789:Enzyme Activation; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008770:Methylnitrosourea / Q000494:pharmacology*; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D010179:Pancreas / Q000201:enzymology; D013696:Temperature
D009607:Nitrosourea Compounds; D008770:Methylnitrosourea; D003851:Deoxyribonucleases
Stimuliatsiia aktivnosti dezoksiribonukleazy pod vliianiem nitrozometilmocheviny.