Susceptibility of multiply antibiotic-resistant pneumococci to the new beta-lactam drugs and rosaramicin.
Eight new beta-lactam antibiotics and rosaramicin were tested for their activity against penicillin-susceptible and multiply resistant pneumococci. All of the beta-lactam drugs were 50- to 150-fold less active against the drug-resistant pneumococci when compared with their activity against penicillin-susceptible pneumococci. Rosaramicin activity was similar to that of erythromycin.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D007933:Leucomycins / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D047090:beta-Lactams / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D007933:Leucomycins; D047090:beta-Lactams