Current status of mammalian and human models for predicting drug photosensitivity.
The status of efforts to develop experimental models for drug photosensitivity reactions in small mammals is reviewed. Tests which are practical and also have a high predictive value in determining photosensitivity hazards to man are the goal of this research. The various animal model systems which have been used are evaluated with respect to these goals.
D000818:Animals; D002478:Cells, Cultured; D004195:Disease Models, Animal; D005620:Freund's Adjuvant; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D010787:Photosensitivity Disorders / Q000139:chemically induced / Q000276:immunology / Q000378:metabolism; D011817:Rabbits; D012867:Skin / Q000187:drug effects / Q000528:radiation effects; D012967:Sodium Dodecyl Sulfate; D013552:Swine; D014466:Ultraviolet Rays
D012967:Sodium Dodecyl Sulfate; D005620:Freund's Adjuvant