title: Colorimetric rate method for the determination of creatinine as implemented by the Beckman Creatinine Analyzer 2.
abstract: We evaluated the performance characteristics of the Beckman Creatinine Analyzer 2, a kinetic colorimetric analyzer which utilizes a modified Jaffé reagent. The instrument gave linear measurements to at least 300 mg/L and its within-run precision on a 50 mg/l creatinine standard was 1.1%. Its between-day precision on the 50 mg/L creatinine standard was less than 5.0%. Its results correlated well with those from the manual Jaffé. CentrifiChem System 400, TechniconTM SMATM 6/60 System, and TraceTM systems I and III. Interferences from 19 possible serum constituents and 32 drugs were almost nonexistent. The extended linear range of the Creatinine Analyzer 2 allowed the direct assay of samples from patients undergoing periodic hemodialysis.
mesh_terms: D001663:Bilirubin / Q000378:metabolism; D003124:Colorimetry / Q000295:instrumentation*; D003404:Creatinine / Q000097:blood*; D005069:Evaluation Studies as Topic; D006801:Humans; D011506:Proteins / Q000378:metabolism
chemical_list: D011506:Proteins; D003404:Creatinine; D001663:Bilirubin