[Effect of nonachlazine on brain and myocardial noradrenaline content in normal rats and rats subjected to stress].
Nonachlazin causes a rapid and significant increase in the noradrenaline content of the rat myocardium and brain stem. The noradrenaline level falls in these tissues under stress reaction induced by immobilization and electric pain stimulation. Nonachlazin pretreatment before stress reaction prevents the decrease of the myocardial noradrenaline level and the development of cardiac ischemic disturbances and arrhythmias (according to the ECG data). However, nonachlazin fails to diminish the noradrenaline level in the brain stem under these conditions.
D000818:Animals; D001923:Brain Chemistry; D009206:Myocardium / Q000032:analysis*; D009628:Nonachlazine / Q000627:therapeutic use*; D009638:Norepinephrine / Q000032:analysis*; D010146:Pain / Q000150:complications; D010640:Phenothiazines / Q000627:therapeutic use*; D051381:Rats; D012149:Restraint, Physical / Q000009:adverse effects; D013312:Stress, Physiological / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism
D010640:Phenothiazines; D009628:Nonachlazine; D009638:Norepinephrine
Vliianie nonakhlazina na soderzhanie noradrenalina v mozge i miokarde krys v norme i v usloviiakh stressa.