An economical hemoperfusion system to determine in vitro clearances of various poisons with different adsorbents.
An economical hemoperfusion system for clearance studies in vitro was developped. It was ascertained, that hemoperfusion using columns which contain 13 g of adsorbent and perfused at a blood flow rate of 1.25 ml/min results in the same relative clearances as when using clinical sized columns containing 300--355 g of the absorbent and run at 100ml/min. The adsorption kinetics of toxicologically important drugs and pesticides are given as examples. To date 27 substances were tested systematically. The investigation has shown, that no adsorbent is without exception the best one, but the efficacy can vary from substance to substance.
D000327:Adsorption; D000818:Animals; D004074:Digitoxin / Q000506:poisoning; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D007700:Kinetics; D008702:Methaqualone / Q000506:poisoning; D008743:Methyl Parathion / Q000506:poisoning; D010269:Paraquat / Q000506:poisoning; D010278:Parathion / Q000506:poisoning; D011041:Poisoning / Q000628:therapy*; D011042:Poisons / Q000097:blood*; D051381:Rats
D011042:Poisons; D008743:Methyl Parathion; D010278:Parathion; D008702:Methaqualone; D004074:Digitoxin; D010269:Paraquat