title: A possible role of endogenous opioids in the control of prolactin and luteinizing-hormone secretion in the human.
abstract: We investigated the participation by endogenous opioid peptides in the control of prolactin and gonadotropin secretion in 5 normal men and 6 normal women, and in 4 men and 5 women with persisting hyperprolactinemia following transsphenoidal pituitary microsurgery for prolactinomas. Iv administration of the specific opiate-receptor antagonist, naloxone hydrochloride (0.2 mg/kg bolus), failed to affect serially sampled serum prolactin levels in normal male or female subjects. With prolactinoma patients, naloxone suppressed hyperprolactinemia to 37% and 32% of mean control values in 2 of 4 males, but in none of 6 females. When luteinizing hormone was serially sampled under the same conditions, 5 of 5 normal males (but no female, normal or abnormal) demonstrated a monophasic increase in serum LH concentrations after injection of the antagonist. The LH peak was 55 +/- 4% above basal levels (p less than 0.01). In contrast to normal men, only one of 4 hyperprolactinemic male patients manifested a stimulatory response of LH to naloxone. Among all 20 subjects, none exhibited a change in FSH levels acutely after naloxone. These data suggest that: i) naloxone will not fulfill its postulated role as an ideal therapy of hyperprolactinemia and hypogonadotropism, at least in women; ii) endogenous opioids may participate in the neuroendocrine regulation of LH secretion in the normal human, iii) male-female differences may modify the role of endogenous opioids; and iv) some male patients with hyperprolactinemia exhibit defective opioid-related neuroregulation of LH secretion.
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000601:surgery; D000328:Adult; D004723:Endorphins / Q000502:physiology*; D005260:Female; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D009270:Naloxone; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000601:surgery; D011388:Prolactin / Q000378:metabolism*; D012737:Sex Factors
chemical_list: D004723:Endorphins; D009270:Naloxone; D011388:Prolactin; D007986:Luteinizing Hormone