Effect of hemorrhage on fever: the putative role of vasopressin.
The effects of hemorrhage on the febrile response of the sheep was examined because hemorrhage is a potent stimulant for arginine vasopressin (AVP) release into cerebrospinal fluid and blood. Removal of 20% of the estimated blood volume of the conscious sheep led to small physiologic changes and significantly decreased fevers in response to bacterial endotoxin. Mean arterial blood pressure decreased in hemorrhaged febrile sheep to a significantly greater extent than in nonhemorrhaged febrile sheep. AVP levels were considerably greater in the blood of hemorrhaged febrile sheep than in nonhemorrhaged febrile sheep and the concentrations correlated with the magnitude of the decrease in fever. Sheep hemorrhaged in the cold had changes in body temperature similar to control sheep. These experiments support the hypothesis that AVP may be an antipyretic neuromodulator.
D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood / Q000134:cerebrospinal fluid / Q000502:physiology*; D001794:Blood Pressure; D005260:Female; D005334:Fever / Q000503:physiopathology*; D006339:Heart Rate; D006470:Hemorrhage / Q000503:physiopathology*; D012756:Sheep
D001127:Arginine Vasopressin