Plasma creatine kinase isoenzymes in the Bar harbor dystrophic mouse.
Increased activity of the MM isoenzyme of creatine kinase (CK) was found in plasma from Bar Harbor dystrophic mice of the 129/ReJ dy/dy strain when compared to the findings in non-dystrophic controls. Total plasma CK activity was only slightly increased in dystrophic animals but plasma from both normal and dystrophic mice showed large amounts of the BB isoenzyme of creatine kinase. This isoenzyme was also found to be present in mouse platelets. It is concluded that BB isoenzyme from platelets could have obscured the contribution of muscle CK to the total plasma CK activity and the CK isoenzyme quantitation is needed to evaluate muscle disorders in rodents.
D000818:Animals; D001792:Blood Platelets / Q000201:enzymology; D003402:Creatine Kinase / Q000097:blood*; D007527:Isoenzymes; D051379:Mice; D009137:Muscular Dystrophy, Animal / Q000097:blood / Q000201:enzymology*
D007527:Isoenzymes; D003402:Creatine Kinase