title: Combined carcinogenic action of chrysotile asbestos dust and N-nitrosodiethylamine on the respiratory tract of Syrian golden hamsters.
abstract: The combined carcinogenic activity of intratracheally inoculated Canadian chrysotile asbestos dust and orally or subcutaneously administered NDEA has been studied in long-term experiments in Syrian golden hamsters. In animals treated with asbestos only, no lung tumours developed, and single tracheal or laryngeal papillomas were found in only a very few cases. In animals treated with asbestos and NDEA, a synergistic effect which increased the incidence of lung tumours was observed.
mesh_terms: D000818:Animals; D001194:Asbestos / Q000009:adverse effects*; D003043:Cocarcinogenesis; D006224:Cricetinae; D004052:Diethylnitrosamine / Q000633:toxicity*; D004391:Dust; D008647:Mesocricetus; D009602:Nitrosamines / Q000633:toxicity*; D011336:Probability; D012142:Respiratory Tract Neoplasms / Q000209:etiology*; D013997:Time Factors
chemical_list: D004391:Dust; D009602:Nitrosamines; D001194:Asbestos; D004052:Diethylnitrosamine