[Pathogenic action of the duodenal contents in acute and chronic exacerbated human pancreatitis].
The authors carried out studies on 16 rabbits - 10 experimental and 6 control with implanted duodenal fistula. They poured for a period of 4 days through the fistula the duodenal content of 6 sick persons with acute and chronic relapsing pancreatitis into the duodenum of the experimental animals and the content of 2 healthy persons-to the animals of the control group. After each pouring the activity of pancreatic and intestinal enzymes was determined in sera and duodenal contents of the rabbits. The duodenum, pancreas, liver and kidneys were examined histomorphologically after killing the experimental animals. The obtained results showed that there were no changes in the enzyme activity and morphologic picture of the organs after pouring duodenal content of healthy persons. The enzyme activity was reduced in the duodenal content of the experimental animals, but in the sera was increased. Pancreatitis, duodenitis, fatty dystrophy of liver and parenchymatous dystrophy of kidneys was established histomorphologically. The authors suggest the appearance of some toxic substances in the duodenal content of sick persons with acute and chronic relapsing pancreatitis.
D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D004386:Duodenum / Q000473:pathology; D006801:Humans; D007419:Intestinal Secretions / Q000378:metabolism*; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D011817:Rabbits
Patogenno deĭstvie na duodenalnoto sŭdŭrzhimo pri ostŭr i khronichen izostren pankreatit u khora.