[Effect of tenoyltrifluoroacetone on the functioning of mitochondria and other membrane structures].
The effects of tenoyltrifluoroacetone (TTFA) on respiration and oxidative phosphorylation of rat liver mitochondria and on the permeability of inner mitochondrial membranes for mono- and divalent cations were studied. It was shown that TTFA, beside being an inhibitor of succinate oxidation and oxidative phosphorylation uncoupler increases the permeability of mitochondria, sarcoplasmic reticulum fragments, liposomes and bilayer phospholipid membranes for Ca2+. The TTFA (150 mkM)-induced permeability of mitochondria for various cations decreases in the following order: Ca2+: H+: Mg2+: Sr2: Ba2+: K+: Na+ = 1:0,07: 0,06: 0,02: 0,015: 0,01. TTFA predominantly stimulates the Ca2+/H+ or Ca2+/Na+ exchange; the membrane-active effects of TTFA are enhanced in the presence of the hydrophobic anion tetraphenylborate and the neutral electron-donating compound tributylphosphate.
D000818:Animals; D002259:Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone / Q000494:pharmacology; D002412:Cations; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008051:Lipid Bilayers; D008081:Liposomes; D008099:Liver / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D013386:Succinates / Q000378:metabolism; D013804:Thenoyltrifluoroacetone / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology*
D002412:Cations; D008051:Lipid Bilayers; D008081:Liposomes; D013386:Succinates; D013876:Thiophenes; D013804:Thenoyltrifluoroacetone; D002259:Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone
Deĭstvie tenoiltriftoratsetona na funktsii mitokhondriĭ i drugikh membrannykh obrazovaniĭ.