[Single dose of thiopental or fentanyl. Hemodynamic effects after treatment by an anti-hypertensive drug: guanoxabenz (author's transl)].
The hemodynamic effects of a single dose of fentanyl (4 micrograms/kg) and of thiopental (5 mg/kg) were studied on cranial trauma patients who have hypertension and who are ventilated at constant volume and frequency. At first the results were collected without an hypertensive treatment, in the second time the same results were collected after the injection of an anti-hypertensive drug (guanoxabenz 70 micrograms/kg). The results showed that in two series the modification in the measured parameters was not statistically significant; the used drugs produced little change in the hemodynamic profile: a) Even with insignificant, we noted that the injection of fentanyl after an anti-hypertensive drug caused a smaller change in the blood pressure and cardiac index then was seen in untreated subjects. b) With thiopental treated subjects, the arterial pressure is not decreased because of the increased systemic resistances, at the same time changes in cardiac index are essentially identical whether or not the subject was treated with guanoxabenz. The results therefore tend to show that the anti-hypertensive treatment can be continued without any interruption by a surgical operation.
D000368:Aged; D000959:Antihypertensive Agents / Q000494:pharmacology*; D006259:Craniocerebral Trauma / Q000503:physiopathology; D004347:Drug Interactions; D005283:Fentanyl / Q000494:pharmacology*; D006143:Guanabenz / Q000031:analogs & derivatives / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008875:Middle Aged; D013874:Thiopental / Q000494:pharmacology*
D000959:Antihypertensive Agents; D006146:Guanidines; D006143:Guanabenz; D013874:Thiopental; C028782:guanoxabenz; D005283:Fentanyl
Effets hémodynamiques d'une injection unique de thiopental ou de fentanyl après le traitement par un anti-hypertenseur: le guanoxabenz.