[Interrelationship of the tranquilizers diazepam and lonetil with dopamine mediation in the central nervous system].
The tranquilizers Diazepam and Lonetyl were examined on rats for their influence on the higher nervous system, using the method of "double escape". Pharmacologic analysis of their action on dopaminergic structures in the central nervous system was performed as well. In this analysis they used dopamine agonist Apomorphine and dopamine antagonist Haloperidol. The authors established that diazepam is small doses did not inhibit dopaminergic system and its activation affected favourably its action, improving conditioned reflex activity. Inhibition of dopaminergic activity by Haloperidol reduced the effect of Diazepam. Lonetil, in contrast to diazepam, inhibited dopaminergic mediation and its sedative effect was increased considerably by Haloperidol.
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology*; D004924:Escape Reaction / Q000187:drug effects; D008297:Male; D008702:Methaqualone / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D011954:Receptors, Dopamine / Q000187:drug effects*
D011954:Receptors, Dopamine; C012409:lonetil M3; D008702:Methaqualone; D003975:Diazepam
Vzaimootnoshenie na trankvilizatorite diazepam i lonetil s dopaminova mediatsiia v tesntralnata nervna sistema.