The effect on prolonged inhalation of crocidolite asbestos on macrophage-lymphocyte interaction.
The effect of prolonged inhalation of crocidolite asbestos on the physical interactions between alveolar macrophages and the T-lymphocyte population was investigated. When macrophages from dusted rats (dusted macrophages) were cultured with lymphocytes, a prolonged physical interaction occurred followed by lymphocyte proliferation. It was demonstrated that dusted macrophages could bind lymphocytes nonspecifically due to the presence of aldehyde-like groups on the membrane. Dusted macrophages could also, as a consequence of antigen-like molecules appearing in the membrane, give rise to specifically sensitized lymphocytes.
D000818:Animals; D001194:Asbestos / Q000008:administration & dosage* / Q000592:standards; D002448:Cell Adhesion; D002455:Cell Division; D002478:Cells, Cultured; D001239:Inhalation; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology* / Q000648:ultrastructure; D008264:Macrophages / Q000276:immunology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D007507:Therapeutic Irrigation
D001194:Asbestos