Bioavailability of progesterone enhanced by intranasal spraying.
The bioavailability of progesterone (P) in terms of area under time-concentration curve and maximal concentration in the serum and cerebrospinal fluid was studied in adult ovariectomized rhesus monkeys following the administration of P as a nasal spray, i.v. or i.m. injections, nasal or eye drops. The bioavailability of P in both the body fluids was found to be considerably higher following its being sprayed intranasally.
D000281:Administration, Intranasal; D000818:Animals; D005260:Female; D007700:Kinetics; D008253:Macaca mulatta; D011374:Progesterone / Q000008:administration & dosage* / Q000097:blood / Q000134:cerebrospinal fluid
D011374:Progesterone