Labeled factor IX kinetics in patients with hemophilia-B.
Labeled factor IX was infused five time into four patients with hemophilia-B. Ten-minute plasma recovery average 35% (SD +/- 2) and the mean T 1/2 beta-phase elimination was 23 hr (+/- 5). No alteration in the postinfusion 125I-factor-IX could be detected by radioautography of plasma samples run on polyacrylamide gels or on crossed-immunoelectrophoresis. Label was excreted into the urine as free 125I-iodide. Kinetics were similar when the labeled preparation was infused alone or with a commercial concentrate containing unlabeled factor IX. Infusion of factor IX in man is best described by a two-compartment open pharmacokinetic model where factor IX is distributed in a space larger than the plasma volume.
D000818:Animals; D002850:Chromatography, Gel; D005164:Factor IX / Q000378:metabolism / Q000652:urine; D006041:Goats; D002836:Hemophilia B / Q000097:blood*; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D007457:Iodine Radioisotopes; D007700:Kinetics; D011817:Rabbits
D007457:Iodine Radioisotopes; D005164:Factor IX