Enhancement of 45Ca2+ binding to acidic lipids by barbiturates, diphenylhydantoin, and ethanol.
Effects of barbiturates, diphenylhydantoin, and ethanol on 45Ca2+ binding to acidic lipids have been examined in an organic, solvent-aqueous partition system. Hexobarbital, pentobarbital, and phenobarbital, at concentrations of 0.3 and/or 0.6 mM, enhanced the binding of 45Ca2+ to phosphatidic acid, phosphatidylserine, and sulfatide but not to phosphatidylinositol or cardiolipin. Diphenylhydantoin, 0.3 mM, enhanced 45Ca2+ binding to phosphatidic acid and phosphatidylserine but not to sulfatide. Ethanol at 80 mM did not enhance 45Ca2+ binding to phosphatidic acid, but ethanol decreased the binding to cardiolipin and increased it to sulfatide.
D001463:Barbiturates / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D002308:Cardiolipins / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D050356:Lipid Metabolism; D010672:Phenytoin / Q000494:pharmacology*; D010712:Phosphatidic Acids / Q000378:metabolism; D010718:Phosphatidylserines / Q000378:metabolism; D013433:Sulfoglycosphingolipids / Q000378:metabolism
D001463:Barbiturates; D002308:Cardiolipins; D010712:Phosphatidic Acids; D010718:Phosphatidylserines; D013433:Sulfoglycosphingolipids; D000431:Ethanol; D010672:Phenytoin; D002118:Calcium