Short-term effects of dietary nitrilotriacetic acid in the male Charles River rat kidney.
Trisodium nitrilotriacetate monohydrate was fed to male weanling Charles River rats for 28 days. Clinical evidence of urinary tract toxicity included hydronephrosis and nephromegaly. Microscopically, severe renal injury was recognized specifically as convoluted tubular cytoplasmic vacuolation and pelvic epithelial erosion. Hyperplasis occurred as a sequela to these specific cytotoxic alterations.
D000818:Animals; D004032:Diet; D006869:Hydronephrosis / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary; D006965:Hyperplasia / Q000139:chemically induced / Q000662:veterinary; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000662:veterinary*; D008297:Male; D009571:Nitrilotriacetic Acid / Q000009:adverse effects; D051381:Rats; D012376:Rodent Diseases / Q000139:chemically induced* / Q000473:pathology
D009571:Nitrilotriacetic Acid