Inhibition of influenza A virus replication by rifampicin and selenocystamine.
The effects of selenocystamine, an inhibitor of influenza virus RNA-dependent RNA polymerase in vitro activity, in the antibiotic rifampicin were studied on influenza A/PR/8/34 (HON1) infection in embryonated eggs. Both drugs completely inhibited hemagglutinating and infective virus yields when added at relatively early times postinfection. Maximal inhibition was produced by apparently noncytotoxic concentrations of 50 microgram of selenocystamine, or of 400 microgram of rifampicin, per egg.
D000818:Animals; D002642:Chick Embryo; D046508:Culture Techniques; D003538:Cystamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D009980:Influenza A virus / Q000187:drug effects* / Q000254:growth & development; D016566:Organoselenium Compounds; D012293:Rifampin / Q000008:administration & dosage / Q000494:pharmacology*; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D014779:Virus Replication / Q000187:drug effects*
D016566:Organoselenium Compounds; C014807:selenocystamine; D012643:Selenium; D003538:Cystamine; D012293:Rifampin