title: Dimensions of fibres in relation to biological activity.
abstract: Intrathoracic tumours were induced in Syrian golden hamsters given intrapleural injections of chrysotile, tremolite or glass fibres; but the carcinogenicity of these materials was reduced or disappeared with reductions in fibre size. After lifetime administration of UICC amosite in drinking-water, a peritoneal mesothelioma, a pulmonary carcinoma and two early squamous-cell carcinomas of the forestomach were found in 4 of 180 hamsters. No tumours related to treatment were found in animals exposed to fibre-shaped particles of cummingtonite/grunerite, mineralogically related to amosite but of shorter length.
mesh_terms: D000818:Animals; D001194:Asbestos / Q000008:administration & dosage* / Q000009:adverse effects / Q000592:standards; D006224:Cricetinae; D004032:Diet; D005069:Evaluation Studies as Topic; D005260:Female; D005898:Glass; D001239:Inhalation; D007267:Injections; D008297:Male; D008647:Mesocricetus; D010316:Particle Size; D013899:Thoracic Neoplasms / Q000209:etiology*; D013997:Time Factors
chemical_list: D001194:Asbestos