Homologous immunotolerance and decreased resistance to Schistosoma mansoni in Echinostoma revolutum-infected mice.
Homologous immunotolerance was demonstrated in Echinostoma revolutum infections in the mouse. High-level infections of about 15 worms were not expelled for a period of at least 61 days following infection, whereas low-level infections of about 10 to 12 worms or below were eliminated completely between day 47 and 61 after infection. A primary, 20- to 33-day-old, heavy E. revolutum infection in the mouse produced a statistically significant increase in the number of Schistosoma mansoni recovered in challenge infections. Worm burdens increased by 65.7 to 90.6% as compared with those of the respective S. mansoni challenge control groups.
D000818:Animals; D004451:Echinostomiasis / Q000150:complications / Q000276:immunology*; D005260:Female; D007108:Immune Tolerance; D051379:Mice; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000150:complications / Q000276:immunology*; D014201:Trematode Infections / Q000276:immunology*