Theophylline inhibition of renal and cerebral nucleoside formation.
1 Theophylline inhibits the enzymatic formation of purine nucleosides, among these adenosine (dephosphorylated adenosine 5'-monophosphate), in kidney and brain of the rat. 2 Some pharmacological effects of theophylline on regional blood flow and electrophysiological activity of the nervous system may be caused by inhibition of the endogenous formation of adenosine.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003864:Depression, Chemical; D007668:Kidney / Q000378:metabolism*; D008297:Male; D010766:Phosphorylation; D011684:Purine Nucleosides / Q000096:biosynthesis*; D051381:Rats; D013806:Theophylline / Q000494:pharmacology*
D011684:Purine Nucleosides; D013806:Theophylline