[Pharmacokinetics of chlodithane tablets in the treatment of Cushing's syndrome].
The results of pharmacokinetic studies of chlodithane tablets hydrophilized with aerosil have shown that the maximum blood concentration of the drug is seen 6 hours after its administration. The most intensive chlodithane absorption by the gastrointestinal tract was noted after using single 1- and 2-g doses (94.9 and 90.8%, respectively). The drug excretion with feces with comparatively low when the daily dose of 4 to 8 g (15.9 to 25.9%) was used. The drug excretion rose to about 50% after the inhibitor dose was increased to over 8 g. It was found that 73.59 +/- 1.87% of the drug is absorbed by the gastrointestinal tract. Thus, it is recommended that chlodithane be administered in a dose of 1 to 2 g 30 minutes after meals with 3- to 4-hour intervals, the daily dose not exceeding 8 g. The recommended scheme provides sufficiently high drug absorption by the gastrointestinal tract and the constant inhibitor concentration in the blood.
D000293:Adolescent; D000328:Adult; D001682:Biological Availability; D003480:Cushing Syndrome / Q000188:drug therapy*; D003632:Dichlorodiphenyldichloroethane / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D008939:Mitotane / Q000378:metabolism*; D013607:Tablets
D013607:Tablets; D008939:Mitotane; D003632:Dichlorodiphenyldichloroethane
Farmakokinetika khloditana v tabletkakh pri lechenii bol'nykh bolezn'iu Itsenko-Kushinga.