High-performance liquid chromatographic determination of trithiozine and its neutral metabolites in human plasma and urine.
A high-performance liquid chromatographic method for the quantitation of the new anti-secretory and antiulcer drug trithiozine in human plasma and urine is reported. The procedure is simple and precise; it allows the simultaneous determination of therapeutic doses of the drug and its three main metabolites, namely, 4-(3,4,5-trimethoxythiobenzoyl)tetrahydro-1,4-oxazine S-oxide, 4-(3,4,5-trimethoxybenzoyl)tetrahydro-1,4-oxazine, and 2-hydroxy-4-(3,4,5-trimethoxybenzoyl)tetrahydro-1,4-oxazine.
D000897:Anti-Ulcer Agents / Q000097:blood / Q000652:urine; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005765:Gastrointestinal Agents / Q000097:blood* / Q000652:urine; D006801:Humans; D009025:Morpholines / Q000097:blood* / Q000378:metabolism / Q000652:urine; D012016:Reference Values; D013997:Time Factors
D000897:Anti-Ulcer Agents; D005765:Gastrointestinal Agents; D009025:Morpholines; C012595:trithiozine