[Protein biosynthesis and thyroglobulin polyribosome content of thyroid cells in congenital goiter].
The basic protein, synthetized in a cell-free (S 30) protein-synthetizing system from the thyroid cells in congenital goitre, is thyroalbumin, while 19S thyroglobulin synthesis is sharply reduced. Determination of the population extent of thyroglobulin polyribosomes has shown that they are practically absent in congenital goitre. It is suggested that thyroglobulin deficit in congenital goitre is provoked by deficiency in functioning thyroglobulin mRNA.
D000293:Adolescent; D000418:Albumins / Q000096:biosynthesis*; D002474:Cell-Free System; D002648:Child; D006042:Goiter / Q000151:congenital* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D011132:Polyribosomes / Q000378:metabolism*; D013954:Thyroglobulin / Q000378:metabolism*; D013961:Thyroid Gland / Q000378:metabolism* / Q000648:ultrastructure; D013963:Thyroid Hormones / Q000096:biosynthesis*
D000418:Albumins; D013963:Thyroid Hormones; C005657:thyralbumin; D013954:Thyroglobulin
Biosintez belkov i soderzhanie tireoglobulinovykh poliribosom v kletkakh shchitovidnoĭ zhelezy pri vrozhdennom zobe.