The chronic toxicity of the preparation M-71 (Craviten).
The studies of chronic toxicity of the preparation M-71 (Craviten) were carried out on rats and mice. The body weight, absolute and relative weight or organs, haematocrit, the number of erythrocytes and leukocytes, the proportional content of leukocytes, OB value, activity of aminotransferases (AspAT and AlAT), the level of glucose in the blood serum and the histopathology of some organs were investigated. Moreover, in rats receiving M-71 intraperitoneally, the amount of electrolytes and the daily excretion of urine was studied. The results suggest that M-71 did not change the investigated parameters.
D000284:Administration, Oral; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000633:toxicity*; D001772:Blood Cell Count; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D005029:Ethylenediamines / Q000633:toxicity*; D005260:Female; D006400:Hematocrit; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D000637:Transaminases / Q000032:analysis
D000889:Anti-Arrhythmia Agents; D001786:Blood Glucose; D005029:Ethylenediamines; C030706:butobendin; D000637:Transaminases