The effect of adrenaline on hepatic lactate uptake in the acidotic partially ischaemic rat liver.
1. The effect of adrenaline (7 X 10(-8) and 7 X 10(-7) mol/l) on lactate uptake and glucose output was studied in the perfused liver of starved rats under conditions of reduced flow and acid perfusate. 2. Adrenaline largely prevented the decrease in hepatic lactate uptake which would otherwise occur owing to reduced blood flow and acidosis and may, therefore, have a protective effect in strenuous exercise and shock.
D000138:Acidosis / Q000378:metabolism*; D000818:Animals; D004837:Epinephrine / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D066298:In Vitro Techniques; D007511:Ischemia / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism*; D008099:Liver / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects; D010477:Perfusion; D051381:Rats
D007773:Lactates; D005947:Glucose; D004837:Epinephrine