The cardiovascular effects of propranolol in adrenalectomized spontaneously hypertensive rats and the opposing influence of rauwolscine.
In conscious adrenalectomized spontaneously hypertensive rats (SHR) propranolol (5 mg/kg s.c.) induced an acute and profound decrease in blood pressure and heart rate, the maximum effect occurring 15-30 min after propranolol administration. The decrease was associated with a fall in cardiac output. Rauwolscine pretreatment abolished the propranolol-induced hypotension but not the bradycardia. The fall in cardiac output was significantly reduced. These results suggest that in adrenalectomized SHR the hypotensive effect of propranolol is due to the modulation of catecholamine release from nerve terminals.
D000315:Adrenalectomy; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D046948:Secologanin Tryptamine Alkaloids / Q000494:pharmacology*
D002395:Catecholamines; D046948:Secologanin Tryptamine Alkaloids; D011433:Propranolol