title: Hemodynamics of LeVeen shunt pulmonary edema.
abstract: In order to characterize the circulatory changes which may lead to pulmonary edema following the surgical placement of a LeVeen peritoneovenous shunt, intraoperative hemodynamic studies were performed on five consecutive patients without clinical evidence of cardiac disease undergoing shunt insertion. Within 30 minutes after opening the peritoneovenous shunt, there was a marked increase in pulmonary capillary wedge pressure, cardiac output, and stroke work index, and a sharp decline in both pulmonary and systemic vascular resistances. In three patients, pulmonary edema did not occur; in one patient, pulmonary edema occurred transiently but responded to furosemide administration. In these four patients, systemic vascular resistance continued to drop over the ensuing hours and the elevated pulmonary capillary wedge pressure also decreased appropriately with furosemide. The fifth patient developed persistent pulmonary edema. In this subject, systemic vascular resistance continued to rise and the elevated pulmonary capillary wedge pressure did not respond to intravenous furosemide. This study suggests that uncomplicated LeVeen peritoneovenous shunt insertion may result in a drop in systemic vascular resistance which lowers left ventricular afterload, and, thus, may protect most patients from pulmonary edema. In contrast, a continued rise in systemic vascular resistance and afterload may contribute to pulmonary edema refractory to diuretic therapy and should probably be treated with a parenteral afterload-reducing agent.
mesh_terms: D001201:Ascites / Q000601:surgery; D002302:Cardiac Output; D004231:Diuresis; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010536:Peritoneovenous Shunt; D011654:Pulmonary Edema / Q000209:etiology* / Q000503:physiopathology; D011669:Pulmonary Wedge Pressure; D013318:Stroke Volume; D014655:Vascular Resistance; D014656:Vascular Surgical Procedures
chemical_list: D005665:Furosemide