title: Fluorescent characteristics of carbamazepine.
abstract: Previously undescribed carbamazepine fluorescence data were found in ethanolic solutions within a range of 200-550 nm. Concentrated H2S04, bidistilled ethanol and a 1:1 mixture of them showed lambda Exc. at 470 nm. A 10-fold fluorescence increase at 470 nm and 520 nm peaks were observed when 10 micrograms of ethanolic carbamazepine solution was activated with the same acid (1:1). A lambda Exc. of 300 nm and Anal. of 357 nm amounted to 60 per cent of the carbamazepine relative fluorescence values in comparison to 95 per cent when a 470/515 nm monochromators combination were used. A 12 hours fluorescence duration was detected for "activated" carbamazepine. The "filter effect" appeared within the range of 10 and 100 micrograms/ml of carbamazepine. Temperature induced an acute fluorescence decay starting at 23 degrees C. Identical wavelengths and others still unidentified were detected from carbamazepine extracted from human serum. The monochromators combination at 300/357 nm might be useful for serum extracted carbamazepine measurements.
mesh_terms: D002220:Carbamazepine; D000431:Ethanol; D005453:Fluorescence; D012996:Solutions; D013050:Spectrometry, Fluorescence; D013464:Sulfuric Acids
chemical_list: D012996:Solutions; D013464:Sulfuric Acids; D002220:Carbamazepine; D000431:Ethanol