title: Electrophysiologic studies of a combination of secobarbital and dibucaine for euthanasia of dogs.
abstract: A combination of secobarbital and dibucaine was compared with secobarbital and with dibucaine, given IV, for euthanasia of dogs. The secobarbital-dibucaine combination was the most effective, as determined by latency to electrical silence of the EEG and ECG, as well as by visual observation of the behavior of the animal. The combination product produced a quiet and rapid death, according to all electrophysiologic changes that were monitored, whereas the barbiturate resulted in prolonged myocardial activity. Dibucaine alone is not desirable for use for euthanasia.
mesh_terms: D000818:Animals; D003992:Dibucaine / Q000008:administration & dosage* / Q000494:pharmacology; D004285:Dogs / Q000502:physiology*; D004338:Drug Combinations; D004594:Electrophysiology; D005065:Euthanasia / Q000662:veterinary*; D005260:Female; D008297:Male; D012631:Secobarbital / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D004338:Drug Combinations; D012631:Secobarbital; D003992:Dibucaine