Cardiovascular depression and thermoregulatory disruption caused by pentothal/halothane anesthesia in the harbor seal, Phoca vitulina.
Anesthesia was induced in the harbor seal (Phoca vitulina) with an intravenous injection of 10 mg/kg thiopental sodium; this was followed by halothane (1%) anesthesia for up to 9.5 h. Cardiac output was reduced to 30% of the pre-anesthesia value (from an average of 11.5 1/min to 3.5 1/min) while systemic blood pressure fell from an average of 150/110 to 80/60. Arterial oxygen partial pressures were somewhat depressed (58-72 Torr) during ventilation with air. Heart rate became stable at 90-100 beats/min. Hypothermia was an occasional problem during the first hour of anesthesia, but this trend reversed and gave way to hyperthermia during prolonged anesthesia.
D000758:Anesthesia / Q000662:veterinary*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects*; D010872:Caniformia / Q000502:physiology*; D002319:Cardiovascular System / Q000187:drug effects*; D005260:Female; D006221:Halothane / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D011651:Pulmonary Artery / Q000187:drug effects; D046048:Seals, Earless / Q000502:physiology*; D012881:Skin Temperature / Q000187:drug effects; D013874:Thiopental / Q000494:pharmacology*
D013874:Thiopental; D006221:Halothane