Congenital obstruction of the lacrimal passages in five consecutive generations.
Congenital epiphora due to absence or imperfection of lacrimal puncta and/or canaliculi was present in 21 members from five consecutive generations of a Sicilian family. The anomaly was transmitted as an autosomal-dominant characteristic with apparently complete penetrance and highly variable expressivity.
D000328:Adult; D002648:Child; D005260:Female; D049668:History, 15th Century; D006801:Humans; D007767:Lacrimal Duct Obstruction / Q000151:congenital* / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology; D008297:Male; D010375:Pedigree; D011859:Radiography