Plasmid specification of resistance to antibacterial compounds in environmental Citrobacter freundii.
Citrobacter freundii from an environmental source displayed resistance to a wide variety of antibacterials. Some of these resistances could be transferred by conjugation with frequencies as high as 10(-2). The complexity of plasmid involvement in the antibacterial resistance of this species was demonstrated by isolation of plasmid DNA from two isolates. In one strain, resistance to beta-lactam antibiotics was specified by a 55 x 10(6) molecular weight plasmid, whereas kanamycin and neomycin resistance was specified by a 7 x 10(6) molecular weight plasmid. Resistance to chloramphenicol and tetracycline was not plasmid mediated. The other strain contained plasmids of molecular weight 113 x 10(6) and 80 x 10(6), which specified resistance to chloramphenicol, neomycin, kanamycin, tetracycline, and mercury.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002954:Citrobacter / Q000032:analysis / Q000187:drug effects / Q000235:genetics*; D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000032:analysis; D004270:DNA, Circular / Q000032:analysis; D008970:Molecular Weight; D011815:R Factors; D014871:Water Microbiology
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D004270:DNA, Circular