The effect of intravenously administered Palerol and Litalgin on the contraction of the human gallbladder.
One ampule of Palerol and one of Litalgin (combination preparations with vagolytic, smooth-muscle relaxing, and analgesic effects) were injected intravenously in a double-blind study in random order to 19 patients having a routine oral cholecystography. Palerol had a significant dilatation effect on the smooth muscle of the contracted gallbladder, but Litalgin only prevented further contraction caused by fatty meals. Side effects were minimal. Palerol seems to be useful in acute gallstone attacks.
D000328:Adult; D000632:Aminopyrine / Q000031:analogs & derivatives*; D000700:Analgesics / Q000494:pharmacology; D001561:Benzilates / Q000008:administration & dosage / Q000494:pharmacology*; D001577:Benzophenones / Q000008:administration & dosage / Q000494:pharmacology*; D004177:Dipyrone / Q000008:administration & dosage / Q000494:pharmacology*; D004338:Drug Combinations / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D005704:Gallbladder / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects*; D010276:Parasympatholytics / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology; D011720:Pyrazoles / Q000008:administration & dosage / Q000494:pharmacology*; D014326:Tropanes / Q000008:administration & dosage / Q000494:pharmacology*
D000700:Analgesics; D001561:Benzilates; D001577:Benzophenones; D004338:Drug Combinations; D010276:Parasympatholytics; D010880:Piperidines; D011720:Pyrazoles; D014326:Tropanes; D000632:Aminopyrine; D004177:Dipyrone; C025757:Palerol; C031519:litalgin; C002416:fenpiverinium bromide, pitofenone hydrochloride, dipyrone drug combination