The action of morphine and naloxone on acid secretion by the rat isolated stomach.
The action of morphine and naloxone on acid secretion by the rat isolated stomach has been studied. Morphine (10(-7) to 10(-4) M) had no effect upon spontaneous acid secretion. Morphine (10(-6) M) did not modify the acid output in response to sub-maximal stimulation by pentagastrin, histamine, bethanechol or isoprenaline. Naloxone (10(-6) M) was without effect on the response to pentagastrin or histamine. Our results suggest that opiate receptors do not modify acid secretion in this preparation.
D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D013270:Stomach / Q000187:drug effects*
D009270:Naloxone; D009020:Morphine; D006632:Histamine; D007545:Isoproterenol