Pharmacological and metabolic studies on amino acid benzocaine derivatives.
Amino acid derivatives of benzocaine have shown local anesthetic properties similar to procaine in infiltration and block anesthesia tests, but were ineffective after topic application. Metabolic studies revealed the possibility of rapid hydrolysis of the derivatives to benzocaine by tissues and plasma hydrolyzing enzymes. Therefore they should be considered as prodrugs.
D000779:Anesthetics, Local / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001566:Benzocaine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D006168:Guinea Pigs; D006868:Hydrolysis; D008297:Male
D000779:Anesthetics, Local; C031052:glycylbenzocaine; C031053:N,N-dimethylglycylbenzocaine; C031054:N,N-dimethylalanylbenzocaine; D001566:Benzocaine