Sideroblastic anemia associated wtih hairy cell leukemia.
A patient with leukemic reticuloendotheliosis ("hairy cell" leukemia) with sideroblastic anemia and an epinephrine-induced platelet-aggregation abnormality is presented. Immunologic membrane marker studies supported a B-lymphocyte origin of the hairy cells. It is hypothesized that a defect in the pluripotent marrow stem cell may be responsible for the hairy cell leukemia and for the intrinsic abnormalities in erythrocytes and platelets.
D000368:Aged; D000756:Anemia, Sideroblastic / Q000150:complications*; D001853:Bone Marrow / Q000648:ultrastructure; D002462:Cell Membrane / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D007943:Leukemia, Hairy Cell / Q000150:complications* / Q000276:immunology / Q000648:ultrastructure; D009000:Monocytes / Q000276:immunology; D010974:Platelet Aggregation; D012397:Rosette Formation
D007074:Immunoglobulin G