Reduction of polymeric azo and nitro dyes by intestinal bacteria.
The O(2)-sensitive reduction of high-molecular-weight aromatic azo and nitro dyes by intestinal bacteria appears to be mediated by low-molecular-weight electron carriers with E(o)' = -200 to -350 mV. This process may allow the design of polymeric azo prodrugs for specific release of certain aromatic amines in the colon.
D001391:Azo Compounds / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism*; D004396:Coloring Agents / Q000378:metabolism*; D007422:Intestines / Q000382:microbiology*; D009282:Naphthalenesulfonates / Q000378:metabolism; D009578:Nitrobenzenes / Q000378:metabolism; D010084:Oxidation-Reduction; D011108:Polymers; D013645:Tartrazine / Q000378:metabolism
D001391:Azo Compounds; D004396:Coloring Agents; D009282:Naphthalenesulfonates; D009578:Nitrobenzenes; D011108:Polymers; C005842:6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt; D013645:Tartrazine