[Vagal acido- and glucoreceptors in the gastro-duodenal region (author's transl)].
Vagal sensitivity to carbohydrates (mainly glucose) and to acids (hydrochloric and acetic acids) was studied in the gastro-duodenal region of anesthetized cats. Action potentials were recorded extracellularly from the nodose ganglion by means of glass microelectrodes. Receptors responding to glucose perfusion were found at this level as well as receptors stimulated by acid perfusion. It is shown that each type of receptor was activated by only one kind of stimulus (carbohydrates and acids, respectively). These receptors must thus be considered as true glucoreceptors or acido-receptors. Being silent before activation, these two types of chemoreceptors discharged at a frequency that varied from 2 to 14 imp/s for the acido-receptors, and from 2 to 30 imp/s for the glucoreceptors. The response could be irregular or regular and might last several minutes. Its latency was short (between 1 and 20 s for both types of chemoreceptors. It was therefore supposed that they were located in the mucosa or neighboring structures. From the conduction velocities (0.8-1.2 m/s), it was concluded that fibers originating from the acido- and glucoreceptors belonged to the C type. Recording of the electromyographic activity from the gastro-duodenal region demonstrated that the gluco- and acid-receptors are involved in the regulation of motility of the gastric and duodenal regions.
D000200:Action Potentials; D000818:Animals; D002415:Cats; D002628:Chemoreceptor Cells / Q000502:physiology*; D004386:Duodenum / Q000294:innervation*; D004553:Electric Conductivity; D005632:Fructose; D005947:Glucose; D006863:Hydrogen-Ion Concentration; D007785:Lactose; D013270:Stomach / Q000294:innervation*; D013649:Taste; D014630:Vagus Nerve / Q000502:physiology*
D005632:Fructose; D005947:Glucose; D007785:Lactose
Acido- et glucorecepteurs vagaux de la région gastro-duodénale.