Lactic acidosis during metformin treatment in an elderly diabetic patient with impaired renal function.
In recent years, lactic acidosis has been described in association with metformin therapy in diabetics. We report a fatal case in an elderly diabetic patient with impaired renal function and cardiac insufficiency. The patient presented with an elevated plasma metformin concentration and a concomitant digitoxin intoxication.
D000138:Acidosis / Q000139:chemically induced*; D000368:Aged; D003920:Diabetes Mellitus / Q000188:drug therapy*; D003928:Diabetic Nephropathies / Q000150:complications*; D004074:Digitoxin / Q000506:poisoning; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications; D007773:Lactates / Q000378:metabolism*; D008687:Metformin / Q000009:adverse effects*
D007773:Lactates; D008687:Metformin; D004074:Digitoxin