'Nephritic factor' may be an autoantibody to C3b or C4b.
We attempted to clarify the character of 'Nephritic Factor' in the alternative (NeFA) and classical pathways (NeFC) of the complement, using an agglutinating and a hemolytic activity assay. The results suggested a possibility that NeFA and NeFC were different in their ability but might appear at the same time in some cases, and that NeFA was anti-C3b autoantibody and NeFC anti-C4b autoantibody.
D001323:Autoantibodies / Q000276:immunology*; D003178:Complement C3 Nephritic Factor / Q000276:immunology*; D003179:Complement C3b / Q000276:immunology*; D003181:Complement C4 / Q000276:immunology*; D003169:Complement Inactivator Proteins / Q000276:immunology*; D003170:Complement Pathway, Alternative; D003171:Complement Pathway, Classical; D006801:Humans
D001323:Autoantibodies; D003178:Complement C3 Nephritic Factor; D003181:Complement C4; D003169:Complement Inactivator Proteins; D003179:Complement C3b