Dopamine partially mediates the cardiovascular effects of naloxone after spinal injury.
Following spinal injury, the opiate antagonist naloxone selectively elevates plasma dopamine levels, with the dopamine changes significantly correlated with improved cardiovascular function. Moreover, the cardiovascular effects of naloxone are significantly attenuated by pretreatment with the dopamine antagonist domperidone. From these data, it is concluded that the cardiovascular effects of naloxone after spinal injury are in part dopamine mediated.
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D004294:Domperidone; D004298:Dopamine / Q000097:blood*; D005260:Female; D009200:Myocardial Contraction / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology*; D009638:Norepinephrine / Q000097:blood*; D010880:Piperidines / Q000494:pharmacology; D013124:Spinal Injuries / Q000503:physiopathology*
D001562:Benzimidazoles; D010880:Piperidines; D009270:Naloxone; D004294:Domperidone; D004298:Dopamine; D009638:Norepinephrine