[Albumin and IGG in the CSF as demonstration of blood-brain barrier damage and of immune response within the CNS (author's transl)].
The Cerebrospinal Fluid (CSF) and the serum of 102 neurological patients was studied in subgroups according to diagnostic criteria. The Blood-Brain-Barrier (BBB) is more severely damaged in cases of cerebral tumors and haemorragic cerebral diseases; synthesis of IgG within the CNS is more pronounced in Multiple Sclerosis (MS) patients in comparison with patients of other groups. The ratio IgG/PT in CSF is very high in MS patients. Considering the degree of increase of the IgG Index and of the ratio IgG/PT in CSF the Authors found the highest values in MS and this is typical of such disease. The degree of increase of the ratio CSF albumin/serum albumin showed highest values in patients with tumors or with haemorragic cerebral diseases.
D000418:Albumins / Q000134:cerebrospinal fluid*; D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D002561:Cerebrovascular Disorders / Q000134:cerebrospinal fluid; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid*; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid; D009494:Neurosyphilis / Q000134:cerebrospinal fluid; D012709:Serum Albumin / Q000032:analysis; D013118:Spinal Cord Diseases / Q000134:cerebrospinal fluid
D000418:Albumins; D002556:Cerebrospinal Fluid Proteins; D007074:Immunoglobulin G; D012709:Serum Albumin
Albumina e immunoglobuline G liquorali, espressione di danno di barriera emato-encefalica e di risposta immunitaria nel sistema nervoso centrale.