Effect of clonidine on the function of the adrenal medulla in rats.
Intravenous administration of clonidine at a dose of 30 microgram/kg produced significant decrease both in spontaneous adrenal nerve activity and in adrenal catecholamine secretion rate in rat. These findings could indicate that clonidine decreases catecholamine secretion from the adrenal medulla via the central nervous system.
D000313:Adrenal Medulla / Q000187:drug effects* / Q000378:metabolism; D000320:Adrenergic Fibers / Q000187:drug effects; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism; D003000:Clonidine / Q000494:pharmacology*; D008297:Male; D051381:Rats
D002395:Catecholamines; D003000:Clonidine