[Cimetidine in experimental gastric ulcers induced by pyloric ligation].
Male albino rats of the Wistar strain, without food from 48 h, have been operated with pylorus ligature and treated with cimetidine, at the dose of 30 mg/kg i.m., just after the operation and 12 h later. Cimetidine reduced the size and the number of gastric ulcers induced by pylorus ligature, showing a significant protective effect. This action, due to the inhibition of gastric secretion induced by cimetidine, supports the hypothesis that the staunching of gastric juice (by pylorus ligature) plays a basic role in the pathogenesis of these experimental gastric ulcers.
D000818:Animals; D002927:Cimetidine / Q000627:therapeutic use*; D005750:Gastric Juice / Q000187:drug effects; D006146:Guanidines / Q000627:therapeutic use*; D008026:Ligation; D008297:Male; D011706:Pyloric Antrum / Q000502:physiology*; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy*
D006146:Guanidines; D002927:Cimetidine
La cimetidina nelle ulcere gastriche sperimentali da legatura pilorica.