A new method for the evaluation of psychoactive drug activity.
A method for the fast and reliable evaluation of the sedative and/or antidepressant activity of drugs has been tested. The drugs were administered in very small quantities directly on the cortex of conscious rabbits, and spectrum analysis of the electro-corticogram, recorded from the place of administration, was used to evaluate the potency of the drug. A quantitisation of the obtained results has been elaborated.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects; D003201:Computers; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004569:Electroencephalography / Q000379:methods*; D005583:Fourier Analysis; D010146:Pain / Q000503:physiopathology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011817:Rabbits
D011619:Psychotropic Drugs