[Effect of the organophosphorus compound neguvon on the dopamine content in the rat brain].
The authors found that the phosphororganic pesticide neguvon in a dose of 200 mg/kg of body weight diminished the content of dopamine in the striatum of white rats. This effect was increased after daily administration of the same dose for a period of 5 days. The reactivator of cholinesterase TMB-4 and H-choline blocker tropacine prevented this effect. They discussed the connection between the changes in the content of dopamine and modulating role of presynaptic choline receptors of H- and M- types in the dopaminergic terminals of the striatum.
D000818:Animals; D001535:Benactyzine / Q000494:pharmacology; D001921:Brain / Q000187:drug effects*; D002801:Cholinesterase Reactivators / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects; D004158:Diphenylacetic Acids / Q000494:pharmacology; D004298:Dopamine / Q000032:analysis / Q000378:metabolism*; D008297:Male; D051381:Rats; D013997:Time Factors; D014236:Trichlorfon / Q000506:poisoning*; D014289:Trimedoxime / Q000494:pharmacology; D014326:Tropanes / Q000494:pharmacology
D002801:Cholinesterase Reactivators; D004158:Diphenylacetic Acids; D014326:Tropanes; C003727:tropacine; D014289:Trimedoxime; D001535:Benactyzine; D014236:Trichlorfon; D004298:Dopamine
Vliiani na fosfororganichnoto sûedinenie neguvon vûrkhu sûdûrzhanieto na dopamin v glaven mozûk na plûkh.