title: Amyotrophic lateral sclerosis: current concepts.
abstract: Amyotrophic lateral sclerosis, a progressive disease characterized by selective loss of upper and lower motor neurons, equals or exceeds multiple sclerosis in incidence. The clinical and pathologic features are discussed, as well as practical management strategies. Also included is an examination of the extensive investigations under way to determine the syndrome's elusive etiology.
mesh_terms: D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis / Q000628:therapy; D002540:Cerebral Cortex / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000473:pathology; D009132:Muscles / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology