Factors affecting adrenocortical hormone function.
This paper will briefly outline those elements which must be considered in assessing the effects of any given compound which might impinge on the actions of adrenocortical steroids. Considerations that ought to be taken into account include the following: the delivery to the affected cells of corticosteroids, the uptake of the hormone by the cells, the metabolism of the hormone by the cells, the intracellular actions of the hormone, the possible secondary interactions between cells, and multihormonal actions on the final target cell.
D000302:Adrenal Cortex / Q000502:physiology*; D000305:Adrenal Cortex Hormones / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D002460:Cell Line; D004790:Enzyme Induction / Q000187:drug effects; D006822:Hybrid Cells / Q000187:drug effects / Q000378:metabolism; D007700:Kinetics; D008114:Liver Neoplasms, Experimental / Q000378:metabolism; D051379:Mice; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000378:metabolism
D000305:Adrenal Cortex Hormones; D012333:RNA, Messenger; D011965:Receptors, Glucocorticoid