Effect of molybdenum and copper on key enzymes of rat kidney with special reference to physiological antagonism.
Enzymological data on alkaline phosphatase, acid phosphatase, glucose-6-phosphatase, cholinesterase and lipase obtained in the kidney of rats, fed on molybdenum (Mo) and copper (Cu), are reported. Antagonistic or synergistic behaviour has been determined by feeding the rats simultaneously on these two metals. Molybdenum inhibited all other enzymes except acid phosphatase and lipase. Complete inhibition of alkaline phosphatase was recorded after copper treatment. The combined treatment with molybdenum and copper exhibited reversible enzyme changes, however, cholinesterase activity remained inhibited.
D000818:Animals; D003300:Copper / Q000494:pharmacology*; D004791:Enzyme Inhibitors; D007668:Kidney / Q000201:enzymology*; D008297:Male; D008982:Molybdenum / Q000494:pharmacology*; D009747:Nutritional Physiological Phenomena; D051381:Rats
D004791:Enzyme Inhibitors; D003300:Copper; D008982:Molybdenum