The influence of thiopentone and alfathesin on succinylcholine-induced fasciculations and myalgias.
Thiopentone doses corresponding to 5.238 mg x kg-1, that is 2UD95 (UD95:unconsciousness dose 95) inhibit the intensity of succinylcholine-induced fasciculations compared with UD95. Alfathesin doses corresponding to 0.570 mg x kg-1, also 2UD95 (calculated as alphaxalone at a concentration of 9 mg/ml in alfathesin), do not have any greater effect on the degree of fasciculations compared to UD95. Furthermore, neither induction agent influences the incidence, distribution and duration of succinylcholine-induced myalgias. The inhibition of the degree of fasciculations caused by thiopentone is believed to be a consequence of a postsynaptic depressant effect of thiopentone at the neuromuscular junction. The evaluation of the degree of succinylcholine-induced fasciculations must take into consideration the dose of thiopentone administered at induction of anaesthesia.
D000328:Adult; D000530:Alfaxalone Alfadolone Mixture / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005207:Fasciculation / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009069:Movement Disorders / Q000139:chemically induced*; D009135:Muscular Diseases / Q000139:chemically induced*; D011184:Postoperative Period; D013390:Succinylcholine / Q000009:adverse effects*; D013874:Thiopental / Q000008:administration & dosage / Q000494:pharmacology*
D000530:Alfaxalone Alfadolone Mixture; D013390:Succinylcholine; D013874:Thiopental