Familial hypospadias in three generations.
Retroglandular hypospadias has been observed in five males in three generations of the same family. Cytogenetic studies of peripheral blood lymphocytes and buccal smears revealed in all investigated patients normal karyotypes 46,XY with elongation of the long arm of chromosome Y (Yq+).
D002648:Child; D002869:Chromosome Aberrations; D006801:Humans; D007021:Hypospadias / Q000235:genetics*; D008297:Male