Prevalence and persistence of C1q binding activity in healthy subjects.
Samples of serum from 885 normal healthy blood donors were tested for the presence of soluble immune complex-like material by a solid-phase C1q binding assay. The majority of donors (93%) had low or undetectable levels of C1q binding activity in their sera, but 6% had levels that were clearly outside the normal distribution. When these individuals were retested after several weeks half of them still had elevated levels of C1q binding activity.
D000936:Antigen-Antibody Complex / Q000378:metabolism*; D001793:Blood Preservation; D003172:Complement C1 / Q000378:metabolism*; D003168:Complement Fixation Tests; D005260:Female; D006358:Hot Temperature; D006801:Humans; D007074:Immunoglobulin G; D008297:Male; D012016:Reference Values; D013205:Staphylococcal Protein A
D000936:Antigen-Antibody Complex; D003172:Complement C1; D007074:Immunoglobulin G; D013205:Staphylococcal Protein A