title: [RNA synthesis in cells chronically infected with rabies virus].
abstract: RNAs of predominantly subgenome size were synthesized in BHK-21 and HEp-2 cells chronically infected with rabies virus in the presence of actinomycin D. An analysis of glyoxale-denaturated intracellular viral RNAs in agarose gel showed the subgenome size of RNA not to be due to its conformation alterations. Hybridization of intracellular RNAs with 125I-RNA or k3H-kDNA of rabies virus demonstrated marked reduction in both transcription and replication of viral genome in chronic infection as compared with acute infection.
mesh_terms: D002460:Cell Line; D004279:DNA, Viral; D003609:Dactinomycin / Q000494:pharmacology*; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral / Q000096:biosynthesis*; D011820:Rabies virus / Q000378:metabolism*; D013997:Time Factors; D014158:Transcription, Genetic / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
chemical_list: D004279:DNA, Viral; D012367:RNA, Viral; D003609:Dactinomycin
vernacular_title: Sintez RNK v kletkakh, khronicheski infitsirovannykh virusom beshenstva.