[Modulation of the effect of morphine on the isolated guinea pig intestine by noradrenaline and serotonin].
The interference of NA and 5-HT on Morphine inhibition on electrically-driven guinea-pig ileum was investigated. The alpha-antagonist Phentolamine (1 gamma/ml) and alpha MT-pretreatment reduced Morphine inhibition on muscle twitch. Similarly, ilea taken from pCPA-pretreated animals were less sensitive to the opioid. In contrast, both NA or 5-HT added either to normal or to amine-depleted tissue enhance Morphine inhibition. Therefore, not only in the brain but also in the guinea-pig ileum NA and 5-HT enhanced opioid effect.
D000818:Animals; D004347:Drug Interactions; D005260:Female; D006145:Guanethidine / Q000494:pharmacology; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects*; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology*
D008781:Methyltyrosines; D012701:Serotonin; D009020:Morphine; D009638:Norepinephrine; D010646:Phentolamine; D006145:Guanethidine
Modulazione dell'effetto della morfina da parte di noradrenalina e serotonina sull'intestino isolato di cavia.