[Leukocyte-adherence-inhibition reactivity in patients with colorectal and pancreatic cancer (author's transl)].
The immunoreactivity of patients with colorectal or pancreatic cancer was investigated by a modified leukocyte adherence inhibition test (LAI). The microcapillary-LAI-test was easy to practise and measurements had a low intra-assay coefficient of variation. The number of false positive results was low, only 1 of 39 patients with benign disease and not one of 13 healthy volunteers reacted in the presence of colorectal carcinoma extracts. In 43 patients with colorectal cancer 17 of 25 (68%) with Dukes' B & C and 15 of 18 (83%) with Dukes' D cancer were LAI positive. Of the 19 patients with colon polyps 6 positive results were observed, exclusively in case of large villous adenomas, polyposis coli and one polyp with a focal carcinoma. 10 of 11 patients with pancreatic cancer reacted in the test. Leukocytes from patients with limited cancer of other source, when tested with colorectal or pancreatic carcinoma extracts, showed a negative LAI response. However, in case of metastatic diseases some crossreactions were observed, which resulted in false positive tests. Following our results, the LAI test could be of value in the diagnosis of gastrointestinal carcinoma.
D000368:Aged; D003108:Colonic Diseases / Q000276:immunology; D003110:Colonic Neoplasms / Q000276:immunology*; D005260:Female; D006801:Humans; D007417:Intestinal Polyps / Q000276:immunology; D007957:Leukocyte Adherence Inhibition Test; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000276:immunology*; D010195:Pancreatitis / Q000276:immunology; D012004:Rectal Neoplasms / Q000276:immunology*; D014020:Tissue Extracts
D014020:Tissue Extracts
Immunreaktivität bei Patienten mit kolorektalen Tumoren und Pankreaskarzinomen im Leukozytenadhärenz-Inhibitionstest.