Plasma levels and urinary excretion of methyl-GAG following iv infusion in man.
The pharmacokinetics of methyl-GAG was studied after nephrectomy in five patients with renal cell carcinoma and in one patient with breast cancer. Following rapid infusion (30 minutes) of 700 mg/m2 of methyl-GAG, terminal half-life of 136-224 hours. Drug levels declined to 6%-20% of the initial plasma concentration in the first 24 hours. Approximately 40% of the dose was recovered in the urine after 2 weeks. Extensive extravascular distribution of methyl-GAG is suggested.
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000378:metabolism; D001943:Breast Neoplasms / Q000188:drug therapy / Q000601:surgery; D005260:Female; D006146:Guanidines / Q000008:administration & dosage*; D006207:Half-Life; D006801:Humans; D007263:Infusions, Parenteral; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000601:surgery; D008935:Mitoguazone / Q000008:administration & dosage* / Q000097:blood / Q000652:urine; D009392:Nephrectomy; D013997:Time Factors
D000970:Antineoplastic Agents; D006146:Guanidines; D008935:Mitoguazone