Accumulation of myocardial lipid droplets in dexamethasone-treated mice.
Conventionally fixed and plastic-embedded myocardial tissue from mice treated with 1 mg/kg body weight dexamethasone for 48 h was examined in the electron microscope. The dexamethasone-treated mice showed a marked increase in the accumulation of lipid droplets, as compared with control animals. The percent volume of lipid droplets, calculated by morphometric analysis, showed a significant increase in the dexamethasone-treated mice. No other ultrastructural difference between dexamethasone-treated mice and controls was observed.
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D008055:Lipids / Q000032:analysis*; D051379:Mice; D009206:Myocardium / Q000032:analysis / Q000648:ultrastructure*; D013223:Statistics as Topic
D008055:Lipids; D003907:Dexamethasone