title: Failure of metergoline to affect the circadian periodicity of plasma cortisol levels in healthy man.
abstract: To investigate the role of serotoninergic system on the control of circadian periodicity of human hypothalamic-pituitary-adrenal axis, effect of a potent 5-HT antagonist, metergoline, on diurnal variation in plasma cortisol levels was studied in five male volunteers. The administration of metergoline did not result in a significant change of plasma cortisol concentrations and its circadian rhythmicity. These results suggest that metergoline does not influence the diurnal secretion of cortisol in normal subjects.
mesh_terms: D000328:Adult; D002940:Circadian Rhythm; D004873:Ergolines / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008711:Metergoline / Q000494:pharmacology*
chemical_list: D004873:Ergolines; D008711:Metergoline; D006854:Hydrocortisone