Testosterone-antibiotic effectiveness on staphylococcus aureus infected rats.
(1) Male castrated rats (testosterone-free) inoculated intraperitoneally with Staph. aureus showed severe damage in their internal organs as determined by pathological examination of the killed animals. (2) Penicillin-G, oxytetracycline and chloramphenicol treatment 24 h after injection markedly decreased the extent of damage. (3) Pretreatment of castrated rats with testosterone propionate for 3 successive days before infection had a protective influence on the internal organs. (4) Testosterone-injected rats when treated with different antibiotics, showed a clear synergistic action with penicillin-G and oxytetracycline but not chloramphenicol.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002701:Chloramphenicol / Q000627:therapeutic use; D004357:Drug Synergism; D008297:Male; D010118:Oxytetracycline / Q000627:therapeutic use; D010400:Penicillin G / Q000627:therapeutic use; D051381:Rats; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000187:drug effects; D013739:Testosterone / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D013739:Testosterone; D002701:Chloramphenicol; D010400:Penicillin G; D010118:Oxytetracycline