title: Autoantibodies to an epidermal protease inhibitor in skin diseases.
abstract: Solid phase radioimmunoassay for measurement of autoantibodies in human sera to an epidermal protein is presented. The protein purified from normal human epidermis is inhibitory to SH-dependent protease and its molecular weight is about 13,000. Antibodies were detected in 139 of the 4,400 sera collected from dermatological patients. Most of the patients suffered from wide-spread eczematous conditions. It is suggested that the antibodies are secondary to the inflammatory conditions, but they may exacerbate or delay the course of the disease.
mesh_terms: D001323:Autoantibodies / Q000032:analysis*; D004817:Epidermis / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D011480:Protease Inhibitors / Q000276:immunology*; D011863:Radioimmunoassay; D012871:Skin Diseases / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D011480:Protease Inhibitors