The effects of lead, d-amphetamine, and time of day on activity levels in the mouse.
Mice were exposed to lead acetate (0.5%) pre- and postnatally, and activity levels were assessed at 21 days of age. Two measures of open field activity were employed at two different times of day across three doses of d-amphetamine. These factors influence the results observed in lead exposed mice and demonstrate that lead's effects on activity are not invariant. Implications for future research as well as the suggestion of an animal model for childhood hyperactivity are discussed.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology*; D007854:Lead / Q000097:blood / Q000494:pharmacology*; D008027:Light; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D011817:Rabbits; D013997:Time Factors
D007854:Lead; D003913:Dextroamphetamine