title: Bile acid assays as an index of cholestasis.
abstract: Four bile acid profiles, bilirubin, alkaline phosphatase, alanine aminotransferase, glutamate dehydrogenase, and isocitrate dehydrogenase were measured in rats in which normal bile flow had been disturbed either by administration of alpha-naphthylisothiocyanate or by surgical ligation of the bile duct. The most sensitive index to the early onset of cholestasis was an increase in total cholate. This increase was measurable before morphological changes could clearly be identified.
mesh_terms: D015058:1-Naphthylisothiocyanate; D000818:Animals; D001647:Bile Acids and Salts / Q000097:blood*; D001663:Bilirubin / Q000097:blood; D002635:Chenodeoxycholic Acid / Q000097:blood; D002779:Cholestasis / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis*; D002793:Cholic Acids / Q000097:blood; D019411:Clinical Laboratory Techniques; D006000:Glycocholic Acid / Q000097:blood; D008297:Male; D051381:Rats
chemical_list: D001647:Bile Acids and Salts; D002793:Cholic Acids; D002635:Chenodeoxycholic Acid; D015058:1-Naphthylisothiocyanate; D006000:Glycocholic Acid; D001663:Bilirubin