[Enzymic splitting of polyurethanes containing dipeptide links in the main polymeric chain].
The paper deals with the proteolytic enzyme induced destruction of new types of segmented polyurethanes, the main chain of which contains dipeptides links: L-phenylalanyl-L-serine and glycyl-glycine. It is established that the chymotrypsin treatment decreases essentially the molecular mass of polyurethane containing the Phe--Ser links and does not affect the molecular mass of polyurethane with Gly--Gly links. Trypsin has no effect on the both types of polymers. Specificity of the chymotrypsin effect on the polymers is confirmed by the data of IR-spectroscopy. Destruction of the both types of segmented polyurethanes, mainly of the dipeptide fragments, is observed when the polymers are implanted into the animal organism.
D002918:Chymotrypsin / Q000378:metabolism*; D004151:Dipeptides; D011140:Polyurethanes; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D004151:Dipeptides; D011140:Polyurethanes; D002918:Chymotrypsin
Fermentativnoe rassheplenie poliuretanov, soderzhashchikh v osnovnoĭ tsepi polimera dipeptidnye zven'ia.