[Therapy of toxin absorption in skin burns. Synthetic skin replacement or tannic acid (author's transl)].
The influence of toxic factors from burned skin on pathogenesis of burn disease has been demonstrated in recent years. For preparation for skin transplantation synthetic material is used. The present study was undertaken to investigate if such material could inhibit the resorption of toxic factors. Specific mitochondrial alterations, which are reproducibly found 5 days after skin burn or application of burn toxin, served as parameter. Rats, which were treated shortly after burn or later with tannic acid were used as controls. Glucose and urea were measured in serum to check the synthetic function. Therapy with Epigard resulted in a better general condition and normal values of glucose and urea, but no reduction of specific mitochondrial alterations. Treatment with tannic acid caused no improvement in general condition, glucose and urea levels were not significantly altered. Only the early application resulted in a reduction of mitochondrial alterations. An otherwise indicated therapy with a synthetic skin material is not suitable for inhibition of the resorption of toxic factors from burnt skin.
D000818:Animals; D001786:Blood Glucose; D002056:Burns / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D005465:Fluorocarbon Polymers / Q000627:therapeutic use*; D047348:Hydrolyzable Tannins / Q000627:therapeutic use*; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000187:drug effects; D051381:Rats; D012869:Skin Absorption / Q000187:drug effects*; D013634:Tannins / Q000627:therapeutic use*; D014527:Uric Acid / Q000097:blood
D001786:Blood Glucose; D005465:Fluorocarbon Polymers; D047348:Hydrolyzable Tannins; D013634:Tannins; D014527:Uric Acid; C010946:polytetrafluoroethane
Zur therapeutischen Beeinflussbarkeit der Toxinresorption bei Hautverbrennungen. Synthetischer Hautersatz oder Tanningerbung.