Serum and saliva levels of 8-methoxypsoralen after rectal administration as a micro-enema.
Serum and saliva concentrations of 8-methoxypsoralen (8-MOP) were determined in seven healthy human volunteers after rectal administration of a micro-enema. High peak serum levels were reached very soon(0.7 + or - 0.3 h) after administration of 8-MOP. Nausea was not experienced. There was a reasonable good linear correlation between 8-MOP concentrations in saliva and serum (r = 0.937). The saliva/serum ratio for 8-MOP concentration was 0.08 +/- 0.02.
D004733:Enema; D007700:Kinetics; D008730:Methoxsalen / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D012007:Rectum; D012463:Saliva / Q000378:metabolism*
D008730:Methoxsalen