The controlled delivery of thiopental and delayed cerebral revascularization.
Sodium thiopental was administered to 10 dogs following embolization of the middle cerebral artery. Its effect on the "grace period" for revascularization was investigated by performing embolectomies 6 hours later. We observed a striking reduction in the size of infarction in the animals treated with thiopental at moderate and prolonged dosage levels. The control animals treated with pentobarbital received less protection against ischemia although blood levels were similar to those of the experimental groups during the period of vascular occlusion.
D000818:Animals; D001463:Barbiturates / Q000008:administration & dosage; D002545:Brain Ischemia / Q000503:physiopathology; D002544:Cerebral Infarction / Q000517:prevention & control; D002548:Cerebral Revascularization; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D010424:Pentobarbital / Q000008:administration & dosage; D013874:Thiopental / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D013997:Time Factors
D001463:Barbiturates; D010424:Pentobarbital; D013874:Thiopental