Phalloidin hepatotoxicity in rats in vivo. Effect of a sympatholytic agent: propranolol.
Phalloidin, one of the main toxins of Amanita phalloides, induced hepatotoxicity in female Wistar rats at 0.9 mg/kg dose i.p. Biliary secretion was selectively inhibited after 3h, but was restored after 24 h. Phalloidin also induced a cytolytic lesion, but not a fatty liver, as in alpha-amanitin intoxication. Propranolol pretreatment (30 min prior to phalloidin injection) did not afford protection against hepatotoxicity, but increased alkaline phosphatase, 5'-nucleotidase and aminotransferase activities.
D000818:Animals; D001646:Bile / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000517:prevention & control*; D002779:Cholestasis / Q000139:chemically induced; D005260:Female; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D009842:Oligopeptides / Q000633:toxicity*; D010590:Phalloidine / Q000037:antagonists & inhibitors / Q000633:toxicity*; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D000637:Transaminases / Q000097:blood
D009842:Oligopeptides; D010590:Phalloidine; D011433:Propranolol; D000637:Transaminases