Phenobarbital treatments lower DDT body burden in rhesus monkeys.
Decreased DDT, DDD, DDE in blood and DDA in urine followed phenobarbital treatments (10 mg/kg/day, 11 days, intramuscular (im)) in three male rhesus monkeys (Macaca mulatta). Animals were fed DDT diets containing up to 500 ppm DDT during a 3-year period. Induction of liver monooxygenases was confirmed by reduced in vivo antipyrine plasma half-life and increased in vitro oxidation rates of dihydroisodrin, p-nitroanisole and benz(alpha)pyrene by homogenates of liver obtained from closed needle biopsy. Chlorohydrocarbon blood levels significantly decreased during the induction period (days 1-11). Concentrations on day 28 were at or below pre-DDT exposure levels. Urine DDA gradually decreased in all monkeys from days 16 to 28.
D000818:Animals; D001822:Body Burden; D003634:DDT / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism* / Q000652:urine; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood; D003632:Dichlorodiphenyldichloroethane / Q000097:blood; D004790:Enzyme Induction / Q000187:drug effects; D008099:Liver / Q000187:drug effects*; D008253:Macaca mulatta; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*
D003633:Dichlorodiphenyl Dichloroethylene; C000849:bis(p-chlorophenyl)acetic acid; D003634:DDT; D003632:Dichlorodiphenyldichloroethane; D010634:Phenobarbital