title: [Effect of hirudin-thrombin and phenylmethylsulfonyl-thrombin on various blood clotting indices].
abstract: Some characteristics of the blood coagulation system were analyzed after injection to rats of hirudin-thrombin and phenylmethylsulfonyl-thrombin devoid of clotting and esterase activities because of the blocking of the substrate binding or catalytic site of the active center. Unlike native thrombin, both forms of modified thrombin did not activate the anticoagulation system.
mesh_terms: D000818:Animals; D001665:Binding Sites; D001777:Blood Coagulation / Q000187:drug effects*; D002942:Circular Dichroism; D004347:Drug Interactions; D006629:Hirudins / Q000008:administration & dosage*; D008297:Male; D010664:Phenylmethylsulfonyl Fluoride / Q000008:administration & dosage*; D051381:Rats; D013450:Sulfones / Q000008:administration & dosage*; D013917:Thrombin / Q000008:administration & dosage*
chemical_list: D006629:Hirudins; D013450:Sulfones; D010664:Phenylmethylsulfonyl Fluoride; D013917:Thrombin
vernacular_title: Vliianie preparatov girudin-trombina i fenilmetilsul'fonil-trombina na nekotorye pokazateli sistemy svertyvaniia krovi.