Histamine H1- and H2-receptors in the mesenteric vascular bed of the pig.
In order to study whether both histamine H1- and H2-receptors are present in the pig mesenteric vascular bed, natural histamine, 2-(2-pyridyl) ethylamine and 4-methylhistamine, as well as mepyramine and metiamide, were infused directly into the superior mesenteric artery. The results indicate that histamine H1- and H2-receptors, both inducing vasodilation, are present in the mesenteric circulation of the pig. Jejunal motility proved to be influenced by H1-receptor stimulation only.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000494:pharmacology; D008638:Mesenteric Arteries / Q000032:analysis*; D008761:Methylhistamines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D011968:Receptors, Histamine / Q000032:analysis*; D011969:Receptors, Histamine H1 / Q000032:analysis* / Q000187:drug effects; D011970:Receptors, Histamine H2 / Q000032:analysis* / Q000187:drug effects; D013552:Swine; D014664:Vasodilation / Q000187:drug effects
D008761:Methylhistamines; D011725:Pyridines; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D006632:Histamine; C006183:2-(2-aminoethyl)pyridine