Effect of reduced extracellular sodium concentration on the function of adrenal zona glomerulosa: studies on isolated glomerulosa cells from the rat.
Aldosterone production by isolated adrenal glomerulosa cells from the rat was estimated in the presence of varying concentrations of sodium ion. The reduction of sodium concentration by 5-20 mmol/l, with or without osmotic changes, did not influence the rate of aldosterone production. Aldosterone response to angiotensin II was not modified by varying the sodium concentration.
D000311:Adrenal Glands / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D000450:Aldosterone / Q000096:biosynthesis*; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D005110:Extracellular Space / Q000378:metabolism; D005260:Female; D066298:In Vitro Techniques; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D012964:Sodium / Q000378:metabolism*
D000804:Angiotensin II; D000450:Aldosterone; D012964:Sodium