Identification of basic drugs by the thin-layer chromatographic profiles of their ninhydrin complexes.
Fifty-two common basic drugs produce various colours when spotted with ninhydrin on plastic thin-layer plates and heated. When the plate is then developed in a suitable solvent each of the coloured spots separates into a variety of additional coloured spots and patches, the number of which depends on the temperature of heating. The relative intensity and spatial arrangement form a profile that is highly characteristic of the compounds. The formation of such profiles was investigated at 100 and 160 degrees C.
D002855:Chromatography, Thin Layer / Q000379:methods; D003116:Color; D009555:Ninhydrin; D004364:Pharmaceutical Preparations / Q000032:analysis*
D004364:Pharmaceutical Preparations; D009555:Ninhydrin