Cytogenetic studies in patients treated with trimethoprim-sulfamethoxazole.
Cytogenetic studies were performed on bone-marrow cells from 12 patients with urinary tract infections treated with trimethoprim-sulfamethoxazole (T + S). An increased number of micronuclei was presented in the patients compared with the control group, whereas structural chromosomal aberrations were not seen. The present study shows that T + S, like other folic acid antagonists, damage the human genetic material, and confirms that the micronucleus test is more sensitive than chromosome analysis in detecting a cytogenetic effect of chemical agents in man.
D001854:Bone Marrow Cells; D002467:Cell Nucleus / Q000187:drug effects; D002869:Chromosome Aberrations; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens; D013420:Sulfamethoxazole / Q000009:adverse effects*; D014295:Trimethoprim / Q000009:adverse effects*
D004338:Drug Combinations; D009153:Mutagens; D014295:Trimethoprim; D013420:Sulfamethoxazole