Bioavailability of aspirin in the presence of dextropropoxyphene/paracetamol combination.
The effect of 2 doses of a combination analgesic preparation (each dose containing 65 mg dextropropoxyphene hydrochloride and 650 mg paracetamol) upon plasma salicylate concentration after a single dose of soluble aspirin (1.2 g) or enteric-coated aspirin (1.2 g) was examined in 6 normal volunteers and compared with the effect of placebo. The dextropropoxyphene/paracetamol caused no reduction in the plasma salicylate level after absorption of soluble aspirin compared with placebo and, although a reduction in plasma salicylate was seen after enteric-coated aspirin in a single subject, this may reflect erratic absorption rather than a drug interaction.
D000082:Acetaminophen / Q000008:administration & dosage / Q000494:pharmacology*; D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000378:metabolism*; D001682:Biological Availability; D011431:Dextropropoxyphene / Q000008:administration & dosage / Q000494:pharmacology*; D004338:Drug Combinations / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male
D004338:Drug Combinations; D000082:Acetaminophen; C011800:acetaminophen, dextropropoxyphene, drug combination; D001241:Aspirin; D011431:Dextropropoxyphene