title: Prolonged brain retention of contrast agent in neonatal herpes simplex encephalitis.
abstract: A neonate with herpes simplex encephalitis type 2 manifested progressively increasing density of the gray matter on serial computed tomographic scans. Postmortem examination of the brain proved the cause of the increased density to be a high concentration of iodine that had been retained following the intravenous administration of sodium diatrizoate 25 and 16 days previously. This demonstrates that a water-soluble iodinated contrast agent or its iodine component may be retained in the brain for a prolonged period of time. It is recommended that such agents be avoided when possible in neonates with herpes simplex encephalitis.
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D003973:Diatrizoate / Q000378:metabolism*; D004660:Encephalitis / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006561:Herpes Simplex / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D007455:Iodine / Q000378:metabolism*; D009336:Necrosis; D014057:Tomography, X-Ray Computed
chemical_list: D003973:Diatrizoate; D007455:Iodine