Single point estimation of phenytoin dosing requirement.
Computer simulation demonstrated that a single serum sample obtained 24 hours after an intravenous loading dose of phenytoin (18 mg/Kg) can, with reasonable accuracy, predict the maintenance dose of phenytoin required to maintain a steady state serum concentration of 15 mg/L. A strong linear correlation (r = 0.959) was found between required phenytoin maintenance dose and the reciprocal of the 24 hour serum concentration.
D006801:Humans; D007700:Kinetics; D010672:Phenytoin / Q000008:administration & dosage* / Q000097:blood
D010672:Phenytoin