Comparison of the effects of atropine and glycopyrrolate on various end-organs.
Atropine and glycopyrrolate (glycopyrronium bromide), a quaternary ammonium drug, were evaluated in volunteers following intramuscular administration with respect to effects on various end-organs with cholinergic innervation. Glycopyrrolate appears to be five to six times more potent than atropine in its antisialogogue effect and also exhibits a selective, though prolonged, effect on salivary secretion and sweat gland activity. It has minimal cardiovascular, ocular and central nervous system effects.
D000328:Adult; D001285:Atropine / Q000494:pharmacology*; D006024:Glycopyrrolate / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D009411:Nerve Endings / Q000187:drug effects*; D011680:Pupil / Q000187:drug effects; D011759:Pyrrolidines / Q000494:pharmacology*; D012463:Saliva / Q000187:drug effects / Q000378:metabolism; D012472:Salivation / Q000187:drug effects; D013545:Sweat Glands / Q000187:drug effects
D011759:Pyrrolidines; D001285:Atropine; D006024:Glycopyrrolate