title: Enterovirus 71 infection: report of an outbreak with two cases of paralysis and a review of the literature.
abstract: Enterovirus 71 (E-71) infection was first reported in 19745 in the United States; subsequent outbreaks were reported in worldwide distribution. In the summer of 1977, we identified 12 patients, mostly children, with E-71 infection. The striking feature of this outbreak is the occurrence of two cases with polio-like paralytic disease. Other diseases associated with E-71 included aseptic meningitis, meningoencephalitis, respiratory disease, gastroenteritis, and hand-foot-mouth disease. The spectrum of illness observed in our community was compared to that seen in other outbreaks. It is suggested that the significance of E-71 lies in its neuropathogenic potential.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks / Q000453:epidemiology; D004769:Enterovirus Infections / Q000150:complications / Q000175:diagnosis*; D005243:Feces / Q000032:analysis; D005260:Female; D005759:Gastroenteritis / Q000209:etiology; D006232:Hand, Foot and Mouth Disease / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008587:Meningitis, Viral / Q000209:etiology; D009518:New York; D010243:Paralysis / Q000209:etiology*