Antagonism of L-glycine to seizures induced by L-kynurenine, quinolinic acid and strychnine in mice.
L-glycine (1-12.5 micrograms, intracerebroventricularly, i.c.v.) completely prevented seizures induced by i.c.v. administration of L-kynurenine, and practically did not modify those induced by another convulsant quinolinic acid, a metabolite of tryptophan, and by strychnine. L-Glycine administered intraperitoneally (i.p.) (1000 mg/kg) decreased lethality after K-kynurenine and quinolinic acid; at doses of 3000 and 4000 mg/kg which are sedative and hypothermic it prolonged the latency of strychnine and L-kynurenine seizures. The convulsant action of pentylenetetrazol was not modified. Kynurenine seizures are suggested to be related to the action of kynurenine on glycine receptors in the central nervous system.
D000818:Animals; D005998:Glycine / Q000494:pharmacology*; D007737:Kynurenine / Q000037:antagonists & inhibitors*; D008297:Male; D051379:Mice; D011725:Pyridines / Q000037:antagonists & inhibitors*; D011805:Quinolinic Acids / Q000037:antagonists & inhibitors*; D012640:Seizures / Q000139:chemically induced* / Q000517:prevention & control; D013331:Strychnine / Q000037:antagonists & inhibitors*
D011725:Pyridines; D011805:Quinolinic Acids; D007737:Kynurenine; D013331:Strychnine; D005998:Glycine