title: The amino-acid sequence of the alpha subunit in bovine brain S-100a protein.
abstract: The brain specific S-100 protein is a mixture of two components S-100a and S-100b with a subunit composition alpha beta or beta 2 respectively. The amino acid sequence of the beta subunit has been previously determined. This paper presents the sequence of the alpha subunit in the S-100a protein. The alpha subunit consists of 93 amino-acid residues and has a relative molecular mass of 10,400. The sequence shows extensive homology (58%) with that of the beta-subunit and shares an apparent calcium binding site in the C-terminal half of the molecule, suggesting a close evolutionary relationship between these subunits.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001923:Brain Chemistry; D002268:Carboxypeptidases; D002417:Cattle; D003488:Cyanogen Bromide; D046911:Macromolecular Substances; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments / Q000032:analysis; D009418:S100 Proteins; D014357:Trypsin
chemical_list: D046911:Macromolecular Substances; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; D009418:S100 Proteins; D002268:Carboxypeptidases; D014357:Trypsin; D003488:Cyanogen Bromide