Spontaneous gastric erosions and ulcerations in BB Wistar rats.
One hundred thirty-four BB Wistar diabetic rats, 31 nondiabetic siblings, and 30 Wistar rats were necropsied. Gastric erosions and ulcers were observed in 43 (32.1%) of the diabetic rats and three (9.7%) of their nondiabetic siblings. None of the Wistar rats showed evidence of gastric mucosal injury. Lesions were most frequently found in the thick-walled, glandular portion of the stomach and were morphologically consistent with stress ulcers. BB Wistar rats may be valuable for studies on gastric stress ulcers.
D000818:Animals; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000662:veterinary; D005260:Female; D008297:Male; D051381:Rats; D012376:Rodent Diseases / Q000453:epidemiology / Q000473:pathology*; D013270:Stomach / Q000473:pathology; D013276:Stomach Ulcer / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*