Inhibition of ultraviolet-induced carcinogenesis by all-trans retinoic acid.
The effects of all-trans retinoic acid (RA) in 0.05%, 0.025% and 0.005% concentrations on ultraviolet (UV) induced carcinogenesis was investigated in the skin of Uscd strain hairless mice. A carcinogenic amount of UV energy was delivered over the 12-mo period of the study. The 0.025% and 0.005% RA solutions did not alter the development of cutaneous cancers. However, the 0.05% RA concentration significantly inhibited the tumor formation in this study.
D000818:Animals; D051379:Mice; D009374:Neoplasms, Experimental / Q000517:prevention & control; D009381:Neoplasms, Radiation-Induced / Q000517:prevention & control*; D009955:Ornithine Decarboxylase / Q000032:analysis; D012878:Skin Neoplasms / Q000517:prevention & control*; D014212:Tretinoin / Q000494:pharmacology*; D014466:Ultraviolet Rays / Q000009:adverse effects*
D014212:Tretinoin; D009955:Ornithine Decarboxylase