Oestrogen receptors and metabolic activity in the genital tract after ovariectomy of ewes with permanent infertility caused by exposure to phytooestrogens.
Characteristics of the uterus anc cervix after ovariectomy of ewes with permanent phytooestrogen infertility (PPI) were compared with controls. Ewes with PPI had more oestrogen-binding sites in the cervix, but not in the uterus. There was no difference between the two groups of ewes in the binding affinity constant of receptors from the uterus or cervix. There were more keratinized cells in the vaginal epithelium of ewes with PPI, and the rates of protein and glycoprotein synthesis in the uterus and cervix were higher in ewes with PPI. These results offer further evidence that PPI in adult ewes is similar to the "persistent oestrus' syndrome in rodents oestrogenized neonatally.
D000818:Animals; D002369:Castration; D002584:Cervix Uteri / Q000378:metabolism*; D004247:DNA / Q000096:biosynthesis; D004967:Estrogens / Q000009:adverse effects*; D004968:Estrogens, Non-Steroidal; D005260:Female; D007247:Infertility, Female / Q000139:chemically induced / Q000378:metabolism / Q000662:veterinary*; D007529:Isoflavones; D048789:Phytoestrogens; D028321:Plant Preparations; D014176:Protein Biosynthesis; D011960:Receptors, Estrogen / Q000378:metabolism*; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced / Q000378:metabolism*; D014599:Uterus / Q000378:metabolism*
D004967:Estrogens; D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; D048789:Phytoestrogens; D028321:Plant Preparations; D011960:Receptors, Estrogen; D004247:DNA