Recent progress in oligonucleotide synthesis.
It was found that some improvements in oligoribo- and oligo-2'-deoxyribonucleotide synthesis via the phosphotriester approach could be achieved using the p-nitrophenylethyl group for phosphate protection due to its stability in the condensation step and its clean removal of DBU and DBN respectively. Recent results will prove the synthetic advantages over known procedures.
D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004952:Esters; D007202:Indicators and Reagents; D008722:Methods; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D009841:Oligonucleotides / Q000138:chemical synthesis*; D009843:Oligoribonucleotides / Q000138:chemical synthesis*; D009943:Organophosphorus Compounds; D013329:Structure-Activity Relationship
D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004952:Esters; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D009843:Oligoribonucleotides; D009943:Organophosphorus Compounds; C013554:1,5-diazabicyclo(4.3.0)non-5-ene; C031033:1,8-diazabicyclo(5.4.0)undec-7-ene