title: Effect of dietary lipid on the acyl group composition of glycerophospholipids of brain endothelial cells in the developing rat.
abstract: The effects of dietary lipid on the acyl group composition of glycerophospholipids of isolated brain endothelial cell fractions have been determined in the developing rat. Rats were fed high-protein diets containing differing dietary linoleic/linolenic acid ratios but having a similar caloric percentage, or were fed a fat-free diet. With a diet supplemented with corn oil (linoleic/linolenic ratio, 47:1), the proportion of acyl groups of the linolenic acid series (n-3) declines in all glycerophospholipid fractions compared with the controls (linoleic/linolenic ratio, 8.5:1), but the proportion of linoleic acid series (n-6) tends to rise. Consequently, the n-6/n-3 ratio of these glycerophospholipids is markedly higher with corn oil than the control diet. N-9 groups (oleic acid series) are consistently lower in proportion. With fat-free diet, the proportion of n-9 groups is higher in these glycerophospholipids than in the controls, but there is no change in the n-6/n-3 ratio. Comparing the changes produced in the adult and the developing cell fraction, the developing cell fraction is more responsive to dietary influence than that of the adult.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000254:growth & development*; D004041:Dietary Fats / Q000494:pharmacology*; D004727:Endothelium / Q000378:metabolism; D005228:Fatty Acids, Essential / Q000494:pharmacology; D005260:Female; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010713:Phosphatidylcholines / Q000378:metabolism*; D010714:Phosphatidylethanolamines / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D013270:Stomach / Q000032:analysis
chemical_list: D004041:Dietary Fats; D005228:Fatty Acids, Essential; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines