[Paraneoplastic hypouricemia in Hodgkin's lymphoma secondary to a renal tubular reabsorption defect of uric acid (author's transl)].
A patient is reported with stage IV-B Hodgkin's lymphoma, lymphocyte depletion type, and associated hypouricemia (1,7 mg/dl). In the few cases described of this association hypouricemia was secondary to a high renal clearance of urate, but in no case was the involved tubular level precisely delimited. In the present case the pyrazinamide and the probenecid tests were performed, disclosing the existence of a possible defect in the postsecretory reabsorptive phase which was improved by therapy. The different pathogenetic mechanisms described to explain this transitory tubular defect are reviewed.
D000328:Adult; D006689:Hodgkin Disease / Q000188:drug therapy / Q000503:physiopathology / Q000652:urine*; D006801:Humans; D007684:Kidney Tubules / Q000503:physiopathology*; D008297:Male; D011339:Probenecid; D011718:Pyrazinamide; D014527:Uric Acid / Q000652:urine*
D014527:Uric Acid; D011718:Pyrazinamide; D011339:Probenecid
Hipouricemia paraneoplástica en el linfoma de Hodgkin por defecto en la reabsorción tubular postsecretora de ácido úrico.