Oedema-inhibiting effect of procyanidin.
The magnitude of rat-paw oedema induced with serotonin, carrageenin or prostaglandin E1 is decreased to a statistically significant extent with the naturally-occurring procyanidin. In the case of carrageenin-oedema, procyanidin is about twice as effective as phenylbutazone. Procyanidin applied intraperitoneally in doses of 10, 20 or 40 mg/kg, exerted no influence on the blood pressure of rats. When, however, it was injected intravenously, a dose of 35 mg/kg caused a slight decrease in the blood pressure of the anaesthetized animal, while doses of 50-100 mg/kg led to long-lasting reduction of blood pressure.
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D044946:Biflavonoids; D002351:Carrageenan / Q000494:pharmacology; D002392:Catechin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D011108:Polymers / Q000494:pharmacology; D044945:Proanthocyanidins; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology
D001578:Benzopyrans; D044946:Biflavonoids; D011108:Polymers; D044945:Proanthocyanidins; D011458:Prostaglandins E; D012701:Serotonin; C017674:procyanidin; D002392:Catechin; D002351:Carrageenan