[Hepatic coma - experimental study with swine (part 1)].
An acute coma hepaticum was produced in 8 pigs by means of one intraperitoneal dose of thioacetamide. Distinct changes in the behaviour of the animals, changes of the biochemical parameters inclusively the enzyme pattern with a typical lesion pattern of the liver parenchyma and a displacement of the plasma amino acids were shown. All pathological changes in comparison with the normal animal characterize the liver insufficiency after 24 hours as a comatose state. This acute toxic model serves as the base for investigations within the physiology of nutrition about parenteral feeding of L-amino acid mixtures in coma hepaticum. The nearly exclusive hepatotropic lesion degree of thioacetamide is suitable as an experimental model for this purpose.
D000081:Acetamides / Q000633:toxicity*; D000641:Ammonia / Q000097:blood; D000818:Animals; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D004573:Electrolytes / Q000097:blood; D004798:Enzymes / Q000097:blood; D005260:Female; D006501:Hepatic Encephalopathy / Q000139:chemically induced* / Q000201:enzymology; D007501:Iron / Q000097:blood; D012709:Serum Albumin / Q000378:metabolism; D013552:Swine; D013853:Thioacetamide / Q000633:toxicity*; D014527:Uric Acid / Q000097:blood
D000081:Acetamides; D004573:Electrolytes; D004798:Enzymes; D012709:Serum Albumin; D013853:Thioacetamide; D014527:Uric Acid; D000641:Ammonia; D003404:Creatinine; D007501:Iron
Das Coma hepaticum - experimentelle Studie am Schwein (1. Mitteilung).