Comparative teratogenicity of cortisone and phenytoin in mice.
Single administrations of cortisone or phenytoin to pregnant mice on Days 11--14 of gestation caused similar skeletal and dissimilar soft tissue fetal anomalies. Cortisone reduced both maternal and fetal weight, whereas phenytoin only reduced fetal weight without adversely affecting maternal weight. A correlation between fetal weight reduction and cleft palate incidence was evident for each drug. Because probit analysis of dose--response regression lines did not deviate from parallelism after drug challenge, it was concluded that cortisone and phenytoin may produce palatal anomalies in the mouse fetus by a similar mechanism.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002972:Cleft Palate / Q000139:chemically induced; D003348:Cortisone / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D051379:Mice; D010672:Phenytoin / Q000633:toxicity*; D011247:Pregnancy; D013723:Teratogens
D013723:Teratogens; D010672:Phenytoin; D003348:Cortisone