Hydroxyzine intoxication in a 13-month-old child.
A case of hydroxyzine toxicity following accidental ingestion in a 13-month old female infant has been presented. A plasma hydroxyzine concentration 8.5 hours after the acute ingestion was 102.7 micrograms/ml and toxicity was manifested primarily by generalized seizures and sinus tachycardia. General supportive care and seizure control with physostigmine resulted in complete recovery within 72 hours. This case represents the first documented report of hydroxyzine toxicity following acute ingestion in a child.
D003975:Diazepam / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006919:Hydroxyzine / Q000097:blood / Q000506:poisoning*; D007223:Infant; D010830:Physostigmine / Q000627:therapeutic use; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D013610:Tachycardia / Q000139:chemically induced
D006919:Hydroxyzine; D010830:Physostigmine; D003975:Diazepam