The effect of imidazole-analogues on bone resorption in vitro: a suggested role for thromboxane A2.
The effects of imidazole, 1-methyl-imidazole and benzimidazole on bone metabolism in vitro were investigated. The relative potencies of these compounds with respect to the inhibition of bone resorption was found to be comparable to their relative effectiveness as inhibitors of platelet microsome thromboxane synthetase activity. Since studies by others have shown that thromboxanes are produced by resorbing bone in vitro, these results suggest that the inhibition of bone resorption by imidazole is related to the inhibition of thromboxane A2 formation. This could imply that thromboxane A2 is an additional arachidonic acid oxidation product that is of importance in the regulation of bone metabolism.
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology; D001862:Bone Resorption / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D007093:Imidazoles / Q000494:pharmacology*; D010281:Parathyroid Hormone / Q000494:pharmacology; D051381:Rats; D013928:Thromboxane A2 / Q000378:metabolism*; D013931:Thromboxanes / Q000378:metabolism*
D001562:Benzimidazoles; D007093:Imidazoles; D010281:Parathyroid Hormone; D013931:Thromboxanes; D013928:Thromboxane A2; C029899:imidazole; C031000:benzimidazole; C018100:1-methylimidazole; D002118:Calcium