Erythrocyte glutathione reductase polymorphism in a Sudanese population.
414 random samples of blood collected from unrelated male blood donors in Khartoum were analysed for erythrocytic glutathione reductase (GSR) phenotypes in relation to glucose-6-phosphate dehydrogenase (G6PD) and haemoglobin types by starch gel electrophoresis. The overall frequencies of GSR1 and GSR2  were found to be 0.9493 and 0.507, respectively. The frequency of GSR0 was very low (0.0241). The frequency of GSR2 was higher in G6PD-deficient subjects compared to normal subjects. GSR phenotypes were not related to the haemoglobin types. However, there was an excess of GSR0 in subjects with haemoglobin AS.
D004912:Erythrocytes / Q000201:enzymology*; D005787:Gene Frequency; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics; D005980:Glutathione Reductase / Q000235:genetics*; D006801:Humans; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic; D013397:Sudan
D005954:Glucosephosphate Dehydrogenase; D005980:Glutathione Reductase