title: Transitory subependymal cysts in the developing rat rhombencephalon.
abstract: A bilaterally symmetrical cystic cavity is situated in the subependymal neuropil of the rostral rhombencephalon of the rat during the perinatal period of ontogeny. These cysts are formed by the confluence of enlarged extracellular spaces in this region between E18 and E20. The cysts are present for about 2 weeks but disappear on about P15 without trace. They have a maximal volume of about 0.004 to 0.006 mm3 on P2, with a rostrocaudal extension of about 200 microm. Their shape is characterized by a medial convexity and a lateral concavity, and they have their maximal circumference at about the middle of the rostrocaudal axis. The caudal portion is juxtaposed to the subependyma, while the rostral part lies in the neuropil of the presumptive griseum centrale pontis. In the lumen and the wall of the cysts are found numerous macrophages, glioblasts and some degenerating axons and dendrites. The significance of these cysts in the context of morphogenesis and the origin of the numerous macrophages within them are both unresolved.
mesh_terms: D000818:Animals; D001369:Axons; D002531:Cerebellum / Q000473:pathology*; D003560:Cysts / Q000473:pathology*; D003712:Dendrites; D004805:Ependyma; D005110:Extracellular Space; D008264:Macrophages / Q000473:pathology; D008526:Medulla Oblongata / Q000473:pathology*; D011149:Pons / Q000473:pathology*; D051381:Rats; D013997:Time Factors