Depression and cerebrospinal fluid citrate.
In relation to studies of calcium metabolism in manic-melancholic patients, the calcium binding metabolite citrate was analyzed in cerebrospinal fluid from 163 psychiatric and non-psychiatric patients. Patients with symptoms of depression, irrespective of whether the origin of the depression was endogenous or exogenous, had significantly higher cerebrospinal fluid citrate concentrations than non-psychiatric patients. Manic patients and other psychiatric patients without symptoms of depression were not significantly different from the non-psychiatric patients. When the mood was normalized after various treatments, cerebrospinal fluid citrate decreased in all groups of depressed patients.
D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D002951:Citrates / Q000134:cerebrospinal fluid*; D003866:Depressive Disorder / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000134:cerebrospinal fluid; D008875:Middle Aged
D000928:Antidepressive Agents; D002951:Citrates