[Effect of enkephalins on central processes regulating hemodynamics].
Intracisternal administration of leu- or met-enkephalins in a dose of 100 micrograms into unanesthetized cats evoked a short-lasting elevation of arterial pressure and tachycardia. After 1.5-2 minutes the blood pressure returned to normal and bradycardia developed (heart rate = 86 +/- 3.4% of initial). Alterations in the arterial pressure and heart rate were prevented by naloxon in a dose of 50-100 micrograms administered into the 4th ventricle. Leu-enkephalin inhibited the sensitivity of the baroreceptor reflex and increased by 69% the pressor reactions evoked by hypothalamus stimulation. Met-enkephalin was half as potent with respect to the baroreceptor reflex and exerted no effect on the hemodynamic reactions evoked by hypothalamus stimulation.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D004723:Endorphins / Q000494:pharmacology*; D004743:Enkephalin, Leucine; D004744:Enkephalin, Methionine; D004745:Enkephalins / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007031:Hypothalamus / Q000187:drug effects*; D007276:Injections, Intraventricular; D008526:Medulla Oblongata / Q000187:drug effects*; D011311:Pressoreceptors / Q000187:drug effects; D012018:Reflex / Q000187:drug effects*
D004723:Endorphins; D004745:Enkephalins; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine
Vliianie énkefalinov na protsessy tsentral'noĭ reguliatsii gemodinamiki.