title: Induction of transplantation immunity to rat colon carcinoma isografts by implantation of intact fetal colon tissue.
abstract: The objective of this study was to demonstrate whether intact fetal colon tissue can induce immunity to large-bowel cancer isografts. Adult rats were immunized against fetal antigens by implantation of mitomycin-C-treated intact fetal colon tissue beneath the renal capsule. Control animals received implants of pieces of intact adult colon tissue. Kidneys containing the implants were removed after 3 or 5 weeks and the rats were challenged with isografts of a 1,2-dimethylhydrazin (DMH)-induced colon carcinoma. Significant inhibition of tumor growth was observed in immunized groups compared to controls. The present results indicate that some embro-fetal antigens expressed in intact colon tissue of 13 to 15-day-old fetuses are also expressed in colon carcinoma cells and can act as transplantation antigens.
mesh_terms: D000818:Animals; D003106:Colon / Q000276:immunology* / Q000637:transplantation; D003110:Colonic Neoplasms / Q000276:immunology*; D005260:Female; D005333:Fetus / Q000276:immunology*; D009368:Neoplasm Transplantation; D051381:Rats; D014181:Transplantation Immunology; D014185:Transplantation, Isogeneic