[New esters of substituted anilinonicotinic and phenylanthranilic acids].
In the search for new non-steroidal antiinflammatory drugs with low ulcerogenic activity, phthalidyl and pivaloyloxymethyl esters of anilinonicotinic and N-phenylanthranilic acids were synthesized. One of them, the 3-phthalidyl ester of 2-([3-(trifluoromethyl)phenyl]amino)-3-pyridinecarboxylic acid, also named talniflumate, showed lower ulcerogenic activity and toxicity and greater antiinflammatory activity than the niflumic acid.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D009539:Nicotinic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D009544:Niflumic Acid / Q000494:pharmacology; D013276:Stomach Ulcer / Q000139:chemically induced; D062367:ortho-Aminobenzoates / Q000138:chemical synthesis* / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D009539:Nicotinic Acids; D062367:ortho-Aminobenzoates; D009544:Niflumic Acid
Nuevos ésteres de ácidos anilinonicotínicos y N-fenilantranílicos sustituidos.