title: Synthesis and biological activity of a new semisynthetic cephalosporin, CN-92,982.
abstract: A new broad spectrum semisynthetic cephalosporin (CN-92,982) was prepared from the condensation of an acetylaminoacylaminophenyl pyridone with trans-7-[(D-2-phenylglycyl) amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-delta 3-cephem-4-carboxylic acid. The new cephalosporin displayed an in vitro antibacterial spectrum similar to other cephaloglycine types such as cefoperazone and SM-1652. The compound produced a high and prolonged blood level following a single intramuscular dose in a dog.
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D002511:Cephalosporins / Q000097:blood / Q000138:chemical synthesis* / Q000494:pharmacology; D004285:Dogs; D004352:Drug Resistance, Microbial; D007700:Kinetics; D051379:Mice
chemical_list: C030879:CN-92,982; D002511:Cephalosporins