Immunobiological and pharmacological properties of thymus factor X (TFX). I. Biological and pharmacological activity.
Detailed investigations on pharmacological properties of biologically active thymus extract were performed. Its acute and chronic toxicity was determined. Influence on the circulatory and the respiratory systems as well as on the parenchymatous and the smooth muscle organs, development of fetuses and reproductive functions were evaluated. Preparation TFX proved to be well tolerated and its acute action was manifested only at high doses injected intravenously. Its effect on the smooth muscle organs and its teratogenic activity were determined in the long-term experiments. It was assumed that it can be introduced in clinical use excluding women in the reproductive period.
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D001769:Blood / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D006224:Cricetinae; D005260:Female; D006413:Hematopoietic System / Q000187:drug effects; D008208:Lymphatic System / Q000187:drug effects; D051379:Mice; D009130:Muscle, Smooth / Q000187:drug effects; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D013949:Thymus Extracts / Q000494:pharmacology* / Q000633:toxicity
D013949:Thymus Extracts