Inhibition of two homeotic mutants of Drosophila by 5-bromodeoxyuridine and fluorouracil.
Nasobemia (Ns) and spineless-aristapedia (ssa40a) are dominant and recessive homeotic mutants of Drosophila which convert parts of the antenna to leg structures. Exposure of Ns and ssa40a larvae to half-lethal concentrations of 5-bromodeoxyuridine (BUdR) and flourouracil (FU) together or separately during the presumptive time of gene action suppresses the expressivity and penetrance of the mutants.
D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D004330:Drosophila / Q000033:anatomy & histology / Q000187:drug effects* / Q000235:genetics; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology*; D005799:Genes, Dominant; D005808:Genes, Recessive; D007814:Larva; D009154:Mutation; D010641:Phenotype
D001973:Bromodeoxyuridine; D005472:Fluorouracil