title: Effect of oral sucrose on blood pressure in the spontaneously hypertensive rat.
abstract: In the spontaneously hypertensive rat (SHR) increased carbohydrate intake without alteration in sodium intake is associated with elevated blood pressure. One week of feeding sucrose-supplemented chow increased blood pressure an average of 14mm Hg (9%) in three separate groups of SHR, but did not affect blood pressure in normotensive rats of the same strain (Wistar-Kyoto-WKY). Fat supplementation (isocaloric to sucrose) was without effect on blood pressure in SHR. These data are consistent with the hypothesis that diet-induced increases in sympathetic activity may elevate blood pressure in susceptible animals.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004041:Dietary Fats / Q000494:pharmacology; D005260:Female; D006973:Hypertension / Q000503:physiopathology*; D051381:Rats; D012964:Sodium / Q000008:administration & dosage; D013395:Sucrose / Q000494:pharmacology*
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D013395:Sucrose; D012964:Sodium