Regulation of phosphate uptake in rat adipocytes by adenosine, catecholamines and thyroid hormones.
Adrenaline and adenosine deaminase decreased the rate of phosphate uptake in isolated rat adipocytes. This effect was inhibited by N6(phenylisopropyl)adenosine. The rate of uptake was decreased by one third if the rats were given triiodothyronine prior to killing. In fat cells from hypothyroid rats, phosphate uptake was not sensitive to adrenaline. Sensitivity was restored by exogenous adenosine deaminase.
D000241:Adenosine / Q000494:pharmacology*; D000243:Adenosine Deaminase / Q000494:pharmacology; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002395:Catecholamines / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology; D007037:Hypothyroidism / Q000378:metabolism; D066298:In Vitro Techniques; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D010710:Phosphates / Q000378:metabolism*; D051381:Rats; D013963:Thyroid Hormones / Q000494:pharmacology*
D002395:Catecholamines; D010710:Phosphates; D013963:Thyroid Hormones; D000243:Adenosine Deaminase; D000241:Adenosine; D004837:Epinephrine