[High-density lipoproteins in children with coronary diseases].
Low HDL-cholesterol and increased LDL-cholesterol have been shown to be cardiovascular risk factors. Recently, HDL/serum cholesterol and HDL/ LDL-cholesterol ratios have been advocated as more reliable indices of cardiovascular risk factors. In a comparative study, lipoprotein-cholesterol and lipoproteins-triglycerides as well as the HDL/serum cholesterol and HDL/LDL-cholesterol ratios were determined in children of patients with coronary heart disease (CHD) and in healthy control children. Sons of CHD patients had significantly lower HDL-cholesterol and HDL/LDL-cholesterol ratios than controls. In daughters, the HDL-cholesterol and HDL/LDL ratio were also decreased reaching significance in HDL only in the 12 to 16 year age group. Under comparative environmental situations, the results suggest that low HDL-cholesterol in children of CHD patients could be genetically determined.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D009203:Myocardial Infarction / Q000097:blood; D014280:Triglycerides / Q000097:blood
D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol
Lipoprotéines de haut densité chez les enfants de malades coronariens.