title: [Disruption of the morphofunctional state of hepatocytes and microcirculation in the liver during prolonged artificial circulation in dogs].
abstract: Qualitative and quantitative analysis was made of morpho-functional and enzymatic changes in the dog liver during long-term extracorporeal circulation. Pronounced necrotic alterations of hepatocytes and microcirculatory disorders were detected by the end of 3-hour extracorporeal circulation. The data obtained indicate the need for correction of circulation in the terminal parts of the vascular bed.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004285:Dogs; D005112:Extracorporeal Circulation / Q000009:adverse effects*; D008099:Liver / Q000473:pathology*; D008102:Liver Circulation; D008107:Liver Diseases / Q000209:etiology*; D008297:Male; D008833:Microcirculation; D009336:Necrosis; D009499:Neutral Red; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D009499:Neutral Red; D013385:Succinate Dehydrogenase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase
vernacular_title: Narushenie morfofunktsional'nogo sostoianiia gepatotsitov i mikrotsirkuliatsii v pecheni pri dlitel'nom i skusstvennom krovoobrashchenii u sobak.