title: Cell-mediated and humoral immunity in West syndrome.
abstract: The immunological status of five children with West syndrome consequent to previous cerebral lesions was investigated. Three children had West syndrome and two were in transition from West to Lennox-Gastaut syndrome. All of them showed cellular immunological deficiencies in the following tests: sensitization to DNCB, intracutaneous reaction to PHA, inhibition of leucocyte migration, blastic transformation of lymphocytes, T and B lymphocytes in peripheric blood and levels of serum immunoglobulins. These immunological deficiencies, of different degrees of severity, were associated to frequent infections in these children. A possible association between the immunological deficiencies and autoimmunity is discussed.
mesh_terms: D000917:Antibody Formation; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000032:analysis; D007223:Infant; D008213:Lymphocyte Activation; D008297:Male; D012882:Skin Tests; D013036:Spasms, Infantile / Q000276:immunology*; D013577:Syndrome
chemical_list: D007136:Immunoglobulins