[Hemodynamic modifications induced by volatile anesthetics halothane, penthrane, ethrane) I. Cardiovascular effects].
We had intended to reckon quantitatively the effects of volatile anaesthetics(Halothane, Ethrane, methoxyflurane or Penthrane) upon cardiovascular system of healthy young mongrel dogs, 5-8 days interval each other. After administration of a Halothane and Penthrane, heart rate(HR) increases of about 30%; blood pressure(BP) is decreasing of same percentage. Halothane causes a slight increase upon pulmonary arterial pressure(PAP), while pulmonary arterial flow(PAF) reaches 40% more than control values. Penthrane decreases of 30% PAP and of about 40% PAF. Ethranic anaesthesia produces a slight fall on HR and BP, while PAP doesn't result significatively modified; a marked decrease(40%) is observed on PAF. Aortic flow(AF) is diminished(from 20 to 30%) by administration of these anaesthetics.


CONCLUSIONS
Halothane causes very significative modifications on circulation, less modifications are produced by Penthrane, while Ethrane doesn't produce any changes.
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D004737:Enflurane / Q000494:pharmacology*; D006221:Halothane / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008733:Methoxyflurane / Q000494:pharmacology*; D011652:Pulmonary Circulation / Q000187:drug effects; D011669:Pulmonary Wedge Pressure / Q000187:drug effects
D000777:Anesthetics; D008733:Methoxyflurane; D004737:Enflurane; D006221:Halothane
Modificazioni emodinamiche indotte da anestetici volatili(Alotano,Pentrano,Etrano): I. Effetti cardiovascolari.