A 13C-NMR study of non-planar distortions in amides.
The technique of 13C-NMR spectroscopy of oriented systems to problems of biological importance has been suggested and used to investigate non-planar distortions in substituted amides--models for peptides. The studies in conjunction with the proton magnetic resonance data on 15N-[13C]methyl[13C]formamide oriented in a nematic solvent provide all the direct dipolar couplings between the interacting nuclei in the system. When the 13C- and the 1H-NMR experiments are performed under non-identical conditions, 22 different direct dipolar couplings are obtained. It is demonstrated that they can be used to determine unambiguously non-planar distortions around the nitrogen atom together with other geometrical data and the molecular order.
D000577:Amides; D002247:Carbon Isotopes; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008968:Molecular Conformation; D009587:Nitrogen Isotopes; D013329:Structure-Activity Relationship
D000577:Amides; D002247:Carbon Isotopes; D009587:Nitrogen Isotopes