title: Physical dependence on morphine fails to develop during the hibernating state.
abstract: Physical dependence on morphine occurs in a typical fashion during the active state of the mammalian hibernator Citellus lateralis, but does not occur when morphine exposure is confined to the hibernating state. Morphine exposure during hibernation can produce stereotyped behavior, thus demonstrating partial responsiveness of the central nervous system to opioids during this natural state.
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D005260:Female; D006605:Hibernation / Q000187:drug effects*; D006801:Humans; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D012589:Sciuridae; D019966:Substance-Related Disorders
chemical_list: D009270:Naloxone; D009020:Morphine