Adjuvant activity of 6-amino-6-deoxy-muramyldipeptides and their acylamino derivatives on the induction of delayed hypersensitivity to azobenzenearsonate-N-acetyl-L-tyrosine in guinea pigs.
The 6-amino-6-deoxy-N-acetylmuramyldipeptides and their 6-acylamino derivatives were shown to be active as adjuvants on the induction of delayed-type hypersensitivity to azobenzenearsonate-N-acetyl-l-tyrosine in guinea pigs. However, 6-acylamino-6-deoxy-N-(acyl)muramyldipeptides were inactive as adjuvants.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives / Q000276:immunology*; D000276:Adjuvants, Immunologic; D000818:Animals; D001391:Azo Compounds / Q000276:immunology*; D006020:Glycopeptides / Q000276:immunology*; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D013329:Structure-Activity Relationship; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000276:immunology; D010132:p-Azobenzenearsonate / Q000031:analogs & derivatives / Q000276:immunology*
D000276:Adjuvants, Immunologic; D001391:Azo Compounds; D006020:Glycopeptides; C000234:azobenzenearsonate-N-acetyl-L-tyrosine; D014443:Tyrosine; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D010132:p-Azobenzenearsonate