The heterologous protection of rats against a challenge with Fasciola hepatica by prior infection with the nematode Nippostrongylus brasiliensis.
Previous infection of rats with nippostrongylus brasiliensis was shown to result in protection against an oral challenge with Fasciola hepatica metacercariae but not against an intraperitoneal challenge with newly excysted juvenile (NEJ) flukes. The timing of the challenge was important and a double infection with the nematode gave more consistent results than a single. Resistance appeared to be associated with a prior induction of intestinal eosinophilia. Sera from these resistant rats, however, failed to induce eosinophil adherence to NEJ flukes in vitro.
D000818:Animals; D004804:Eosinophils / Q000276:immunology; D005210:Fasciola hepatica; D007114:Immunization; D007422:Intestines / Q000276:immunology; D008297:Male; D008407:Mast Cells / Q000276:immunology; D009349:Nematode Infections / Q000276:immunology*; D009559:Nippostrongylus; D051381:Rats