Effects of anticonvulsants and methotrexate on calcium disposition.
Administration of phenytoin for 5 days significantly reduced oral absorption and bone uptake of radiolabelled calcium in mice. Acute treatment with phenytoin had no effect on calcium disposition. Pretreatment (1--5 days) with phenobarbital also had no effect of calcium disposition. Methotrexate pretreatment for 5 days increased the bone uptake of radiolabelled calcium presumably by decreasing calcium renal clearance. It is concluded that phenytoin induced reduction in calcium metabolism is unrelated to a state of functional folate deficiency.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D005492:Folic Acid / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice; D010634:Phenobarbital / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology
D000927:Anticonvulsants; D002132:Calcium Radioisotopes; D010672:Phenytoin; D005492:Folic Acid; D002118:Calcium; D008727:Methotrexate; D010634:Phenobarbital