A polymorph bactericidal defect and a lupus-like syndrome.
We describe a child with primary defect of polymorph bacterial killing associated with systemic lungs erythematosus. We suggest that her autoimmune disease results from chronic bacterial antigen stimulation and propose a hypothetical model linking immunodeficiency with autoimmunity.
D001770:Blood Bactericidal Activity; D002648:Child; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008180:Lupus Erythematosus, Systemic / Q000209:etiology*; D009504:Neutrophils / Q000276:immunology*; D009580:Nitroblue Tetrazolium; D010585:Phagocyte Bactericidal Dysfunction / Q000150:complications*
D007457:Iodine Radioisotopes; D009580:Nitroblue Tetrazolium