title: Modulation of synaptic output by the transient outward potassium current in aplysia.
abstract: The mechanisms involved in synaptic output modulation by presynaptic membrane potential was studied in identified Aplysia synapses, where a presynaptic hyperpolarization reduces the postsynaptic potential amplitude. The experiment reported here reveals that a presynaptic conditioning hyperpolarization induces a decreased presynaptic spike amplitude and that the reduction is due to a superimposition of a transient outward potassium current on the inward current. This is demonstrated by the external application of 4-aminopyridine which suppresses the early outward current and thus suppresses the modulation both of the presynaptic spike amplitude and the synaptic output.
mesh_terms: D015761:4-Aminopyridine; D000631:Aminopyridines / Q000494:pharmacology; D000818:Animals; D001048:Aplysia / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D009467:Neuromuscular Depolarizing Agents / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects / Q000502:physiology*
chemical_list: D000631:Aminopyridines; D009467:Neuromuscular Depolarizing Agents; D015761:4-Aminopyridine; D011188:Potassium