[Studies on urinary excretion of gonadotropin (LH) in response to the treatment of uterine cervical cancer (author's transl)].
Because of contradictory results on urinary excretion of gonadotropin after gynecologic operation, the present experiment was performed in patients who received radical hysterectomy or radiation therapy for uterine cancer. To measure serum and urinary LH, radioimmunoassay and Hi-Gonavis (HAR) were used. 1. After radical hysterectomy, serum LH decreased lightly whereas urinary excretion of LH increased significantly. 2. Similar decrease of serum LH and increase of urinary LH were found after radiation therapy. 3. Under less severe operative procedures such as semiradical hysterectomy and simple hysterectomy, an increase of urinary excretion of LH was less marked. 4. Administration of hydrocortisone to normal subjects caused a similar increase of urinary excretion of LH. 5. Pituitary responsiveness to LH-RH and renal function were not altered under operation or radiation therapy. On the basis of these findings, it is suggested that urinary excretion of LH is increased by the excess of adrenal steroid produced by operative stress or radiation therapy.
D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007889:Leiomyoma / Q000097:blood / Q000601:surgery* / Q000652:urine; D007986:Luteinizing Hormone / Q000097:blood / Q000652:urine*; D011184:Postoperative Period; D011863:Radioimmunoassay; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000601:surgery* / Q000652:urine
D007986:Luteinizing Hormone; D006854:Hydrocortisone