Effect of the antidiabetic treatment of hyperlipoproteinemia in newly detected diabetes mellitus.
A parallel study concerning the influence of antidiabetic treatment of the carbohydrate and lipid disturbances were carried out in 209 patients with newly discovered diabetes mellitus: 120 females and 89 males, ranging in age from 28 to 73 years. The treatment applied in terms of the clinical from of the disease was: insulin in 12 cases, tolbutamide in 25 cases, glurenorm (a sulphenyl urea derivative in 114 cases, biguanide in 45 cases, tolbutamide associated with biguanide in 13 cases. After 60 days of treatment, the incidence of HLP fell from 55.02% to 43.06% (in 90 of 209 cases), with a change in the distribution of the five HLP types. Parallel analysis of blood glucose, triglycerides (Tg) and cholesterol (Ch) revealed appraisable differences in the post-therapeutic evolution of the three biochemical parameters in terms of the treatment applied. A statistically significant, parallel and comparable decrease in glycemia, Tg and Ch was recorded after insulin and glurenorm; biguanides lowered only glycemia and Tg, and tolbutamide only glycemia. The fact that correction of carbohydrate disturbances is accompanied by a significant decrease only of Tg and not of Ch suggests that the pathophysiologic mechanisms by which these lipid fractions are modified in diabetes mellitus, differ and are probably independent on one another. The close relationship between the weight excess and plasma Tg (but not also plasma Ch) levels, likewise lends support to this assumption.
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D006951:Hyperlipoproteinemias / Q000209:etiology*; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000494:pharmacology
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol