Voltage clamp study of cat spinal motoneurons during strychnine-induced seizures.
Cat spinal motoneurons were examined by the technique of somatic voltage clamp during strychnine-induced spinal seizures. No clear alteration of voltage-dependent ionic currents was required in order for typical strychnine-induced paroxysmal depolarization shifts (PDSs) to develop in contrast to results previously obtained during penicillin-induced spinal seizures. Voltage clamp of evoked and spontaneous PDSs indicates these are generated by a synchronized mixture of excitatory and inhibitory synaptic currents wih excitation predominating.
D000818:Animals; D002415:Cats; D008564:Membrane Potentials / Q000187:drug effects; D009046:Motor Neurons / Q000502:physiology*; D012584:Sciatic Nerve / Q000502:physiology; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D013116:Spinal Cord / Q000503:physiopathology*; D013331:Strychnine / Q000494:pharmacology
D013331:Strychnine