[Changes in tumor cell sensitivity to the action of triterpene glycosides in liposomes].
The effect of the increased levels of cholesterol in ascites tumor cells of mouse sarcoma 37 on the cytochemical activity of 4 triterpene glycosides was studied. A definite correlation between the increase in the cholesterol level in the cells and the glycoside activity was noted. The effect character of some triterpene glycosides depended on the pH value of the medium.
D000818:Animals; D002478:Cells, Cultured; D002784:Cholesterol / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006027:Glycosides / Q000627:therapeutic use*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008081:Liposomes / Q000008:administration & dosage*; D051379:Mice; D012511:Sarcoma 37 / Q000188:drug therapy* / Q000378:metabolism; D014315:Triterpenes / Q000627:therapeutic use*
D006027:Glycosides; D008081:Liposomes; D014315:Triterpenes; C018398:theasaponine; C001883:stichoposide; D002784:Cholesterol
Izmenenie chuvstvitel'nosti opukholevykh kletok k deĭstviiu triterpenovykh glikozidov liposomami.