[Cimetidine and the hypothalamo-hypophysial-suprarenal axis].
The effects of cimetidine on experimental stress, induced by a long time fast and pylorus ligature, in male albino rats were investigated. The drug at the dose of 30 mg/kg was administered i.m. just after the operation and 12 h later. To evaluate the interference of cimetidine on the hypothalamo-hypophyseal-adrenal axis were dosed, in the rat, the level of adrenal ascorbic acid and cholesterol as well as corticosterone plasma levels. The results seem to suggest that cimetidine, in this experiment, is unable to modify stress induced changes.
D000818:Animals; D001205:Ascorbic Acid / Q000032:analysis; D002784:Cholesterol / Q000032:analysis; D002927:Cimetidine / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood; D006146:Guanidines / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects*; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism*
D006146:Guanidines; D002927:Cimetidine; D002784:Cholesterol; D001205:Ascorbic Acid; D003345:Corticosterone
Cimetidina ed asse ipotalamo-ipofiso-corticosurrenalico.