Dose-response effects of tropicamide HCl.
Using double-masking procedures, the mydriatic and cycloplegic effects of 0.25, 0.5, 0.75, and 1.0% tropicamide were studied. All doses produced clinically useful mydriasis of at least 6-mm pupils. Using testing conditions of both normal (35 ft-c) and bright (150 ft-c) illumination, no mydriatic dose-response differences for the four concentrations were found. Cycloplegic effects were dose related. A single drop of either 0.75 or 1.0% tropicamide reduced the amplitude of accommodation to about 1.5 D, which is adequate for a cycloplegic refraction.
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D009184:Mydriatics / Q000494:pharmacology*; D011680:Pupil / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology*; D012029:Refraction, Ocular; D014331:Tropicamide / Q000494:pharmacology*
D009184:Mydriatics; D011725:Pyridines; D014331:Tropicamide