Methotrexate resistance in al L1210 cell line resulting from increased dihydrofolate reductase, decreased thymidylate synthetase activity, and normal membrane transport. Computer simulations based on network thermodynamics.
D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D003201:Computers; D004351:Drug Resistance; D007700:Kinetics; D007939:Leukemia L1210 / Q000378:metabolism*; D008297:Male; D008727:Methotrexate / Q000378:metabolism / Q000494:pharmacology*; D008780:Methyltransferases / Q000378:metabolism*; D051379:Mice; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*; D013816:Thermodynamics; D013940:Thymidylate Synthase / Q000378:metabolism*
D013762:Tetrahydrofolate Dehydrogenase; D008780:Methyltransferases; D013940:Thymidylate Synthase; D008727:Methotrexate