Course of pregnancy and family history in children with malformations of the urinary tract.
Catamnestic investigations were performed in 291 children with malformations of the urinary tract. In renal and vesical malformations both sexes were equally affected, whereas girls were more affected (1.5 :1) than boys with malformations of the renal pelvis and the ureter. Malformations of the urethra included only boys. Parental age was not different from the average parental age at time of delivery in any group. Genetic influences could be assumed in 8.8%. The incidence of malformations of both the urinary and other organ systems in relatives was 8-times higher than in the average population (P less than 0.005). Malformations of the urinary system and unspecified renal diseases were observed in relatives of 22.5% of our children. Nothing conspicuous could be found in the menstrual cycle, abortion rate, haemorrhage during pregnancy and smoking behaviour during pregnancy in the women of the study; 35.1% of them took drugs and 8.2 underwent X-ray investigations during pregnancy.
D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006580:Genetic Carrier Screening; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities; D008297:Male; D010375:Pedigree; D010641:Phenotype; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology*; D014513:Ureter / Q000002:abnormalities; D014521:Urethra / Q000002:abnormalities; D001743:Urinary Bladder / Q000002:abnormalities; D014551:Urinary Tract / Q000002:abnormalities*