[The effect of desoxycholate on the electrolyte and water absorption in the terminal ileum. Studies in conscious rats (author's transl)].
With an in vivo perfusion technique the influence of 10(-3) mol/l desoxycholate (DC) on the net electrolyte and volume absorption are studied in the terminal ileum of unanesthetized rats. Control experiments are performed in the same animal. The following data are observed: 1. There is a highly significant decrease in net Cl- absorption (p less than 0.002). 2. The Na+ and volume absorption is diminished or reversed into secretion. 3. The K+ secretion is enhanced (P less than 0.01). The sodium-water equivalent is reduced caused by alteration of the Na+ as well as the water permeability.
D000818:Animals; D002712:Chlorides / Q000378:metabolism; D003840:Deoxycholic Acid / Q000494:pharmacology*; D005260:Female; D007082:Ileum / Q000187:drug effects*; D007408:Intestinal Absorption / Q000187:drug effects*; D009994:Osmolar Concentration; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D002712:Chlorides; D003840:Deoxycholic Acid; D012964:Sodium; D011188:Potassium
Die Wirkung von Desoxycholat auf die Elektrolyt- und Wasserabsorption im terminalen Ileum. Perfusionsversuche an der wachen Ratte.