title: Monocyte alpha-naphtyl esterase deficiency in chronic granulomatous disease.
abstract: Monocytes from five unrelated children (four boys and a girl) with chronic granulomatous disease were studied for their ability to reduce nitroblue tetrazolium dye after stimulation with zymosan, and for their alpha-naphtyl butyrate esterase activity. As expected, monocytes ingested zymosan particles but failed to reduce nitroblue tetrazolium dye. However, monocytes from two boys out of the five patients were alpha-naphtyl butyrate esterase-negative, whereas both their neutrophils and monocytes were positive for granular naphtol AS-D esterase activity.
mesh_terms: D002265:Carboxylic Ester Hydrolases / Q000172:deficiency*; D002448:Cell Adhesion; D011232:Chemical Precipitation; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000201:enzymology*; D006801:Humans; D008297:Male; D009000:Monocytes / Q000201:enzymology*; D010544:Peroxidases / Q000378:metabolism
chemical_list: D010544:Peroxidases; D002265:Carboxylic Ester Hydrolases; C021855:naphthylbutyrate esterase