title: [Effect of fluorothane anesthesia on liver function in children suffering from lymphogranulomatosis].
abstract: The effects of different kinds of anesthesia on the function of live (evaluated on the basis of activity of enzymes -- aspartate aminotransferase, fructose-I-monophosphate aldelase and glutamate dehydrogenase) were studied in 63 infantile patients with Hodgkin's disease who underwent diagnostic laparotomy with splenectomy. It was found that during the first 6 days after surgery, the rate of activity of these enzymes shows a rise and reaches the upper limits in 77.8% of cases. Halothane anesthesia induced excessive enzymatic activity in 100%, while neuroleptanalgesia -- in 53.8% of cases. Repeated application of halothane produced a higher hepatotoxic effect as manifested by enhanced activity of glutamate dehydrogenase on days 1--2 after operation.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004789:Enzyme Activation / Q000187:drug effects; D004986:Ether; D006221:Halothane / Q000009:adverse effects*; D006689:Hodgkin Disease / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D007813:Laparotomy; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D009458:Neuroleptanalgesia; D013156:Splenectomy; D013997:Time Factors
chemical_list: D004986:Ether; D006221:Halothane
vernacular_title: Vliianie ftorotanovogo narkoza na funktsional'noe sostoianie pecheni u deteĭ, stradaiushchikh limfogranulematozom.