title: On the biosynthesis and metabolism of N-acylethanolamine phospholipids in infarcted dog heart.
abstract: Minced tissues from both infarcted and apparently normal areas of canine myocardium 6 h after ligation of the left descending branch of the coronary artery were incubated with [1,2-(14)C]ethanolamine. In each case substantial amounts of radioactivity were incorporated into both phosphatidylethanolamine and N-acylphosphatidylethanolamine. Incubation of homogenates from the same tissues with N-[1-(14)C]palmitoyl phosphatidylethanolamine yielded labeled N-palmitoyl ethanolamine. The data support the concept that N-acylethanolamines, pharmacologically active compounds which accumulate in infarcted myocardium, are produced by N-acylation of ethanolamine phospholipids followed by phosphodiesterase action.
mesh_terms: D000215:Acylation; D000818:Animals; D004285:Dogs; D004983:Ethanolamines / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D008026:Ligation; D008297:Male; D008660:Metabolism; D009203:Myocardial Infarction / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D010714:Phosphatidylethanolamines / Q000378:metabolism; D010743:Phospholipids
chemical_list: D004983:Ethanolamines; D005227:Fatty Acids; C022203:N-acylethanolamines; D010714:Phosphatidylethanolamines; D010743:Phospholipids