Effect of dietary lipid on the acyl group composition of glycerophospholipids of brain endothelial cells in the developing rat.
The effects of dietary lipid on the acyl group composition of glycerophospholipids of isolated brain endothelial cell fractions have been determined in the developing rat. Rats were fed high-protein diets containing differing dietary linoleic/linolenic acid ratios but having a similar caloric percentage, or were fed a fat-free diet. With a diet supplemented with corn oil (linoleic/linolenic ratio, 47:1), the proportion of acyl groups of the linolenic acid series (n-3) declines in all glycerophospholipid fractions compared with the controls (linoleic/linolenic ratio, 8.5:1), but the proportion of linoleic acid series (n-6) tends to rise. Consequently, the n-6/n-3 ratio of these glycerophospholipids is markedly higher with corn oil than the control diet. N-9 groups (oleic acid series) are consistently lower in proportion. With fat-free diet, the proportion of n-9 groups is higher in these glycerophospholipids than in the controls, but there is no change in the n-6/n-3 ratio. Comparing the changes produced in the adult and the developing cell fraction, the developing cell fraction is more responsive to dietary influence than that of the adult.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000254:growth & development*; D004041:Dietary Fats / Q000494:pharmacology*; D004727:Endothelium / Q000378:metabolism; D005228:Fatty Acids, Essential / Q000494:pharmacology; D005260:Female; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010713:Phosphatidylcholines / Q000378:metabolism*; D010714:Phosphatidylethanolamines / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D013270:Stomach / Q000032:analysis
D004041:Dietary Fats; D005228:Fatty Acids, Essential; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines