title: Seizures induced by acute loxapine overdose.
abstract: The author reviewed records of 10 patients who had experienced acute loxapine overdose. The most frequent medical complications were CNS depression, sinus tachycardia, hypertension, and hypothermia; 6 patients had had generalized major motor seizures, 1 had had recurrent paroxysmal atrial tachycardia, and 2 had had transient renal insufficiency from rhabdomyolysis and myoglobinuria. Other clinical effects from loxapine overdose were predominantly anticholinergic. The author recommends that loxapine-overdose patients receive ECG monitoring and treatment of medical complications in an intensive care unit.
mesh_terms: D000208:Acute Disease; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects; D003989:Dibenzoxazepines / Q000506:poisoning*; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008152:Loxapine / Q000506:poisoning* / Q000627:therapeutic use; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy; D012640:Seizures / Q000139:chemically induced*; D014474:Unconsciousness / Q000139:chemically induced
chemical_list: D003989:Dibenzoxazepines; D008152:Loxapine