Reovirus inhibition of cellular DNA synthesis: role of the S1 gene.
Type 3 reovirus inhibits L cell DNA synthesis, whereas type 1 reovirus exerts little or no effect on L cell DNA synthesis. By using recombinant viruses containing both type 1 and type 3 double-standard RNA segments, we determined that one double-stranded RNA segment, the reovirus type 3 S1 double-stranded RNA segment which encodes the viral hemagglutinin, segregates with and is responsible for the capacity of reovirus type 3 to inhibit L cell DNA synthesis.
D000818:Animals; D002472:Cell Transformation, Viral; D004247:DNA / Q000096:biosynthesis*; D005814:Genes, Viral; D007739:L Cells; D051379:Mice; D012087:Reoviridae / Q000235:genetics* / Q000528:radiation effects; D014466:Ultraviolet Rays
D004247:DNA