Arginine thiazolidinecarboxylate 14C uptake by individual phospholipids isolated from rat liver microsomes.
The transmethylating activity of ATCA was directly evaluated by administering ATCA 14C to a group of rats. The radioactivity associated with the labile methyl group was recovered in microsomal phospholipids, and in particular in the phosphatidylethanolamine and phosphatidylcholine fractions. These biochemical data on the transmethylating activity of the drug confirm a previous indirect demonstration of the protective activity of ATCA in experimental intoxications and elucidate its mechanisms.
D000818:Animals; D001120:Arginine / Q000378:metabolism*; D002250:Carbon Radioisotopes; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D013844:Thiazoles / Q000378:metabolism*; D053778:Thiazolidines
D002250:Carbon Radioisotopes; D010743:Phospholipids; D013844:Thiazoles; D053778:Thiazolidines; C020213:arginine thiazolidinecarboxylate; D001120:Arginine