Inhibition of intestinal glucose absorption in several animal species by cytochalasins.
The effect of various cytochalasins on intestinal glucose absorption in several animals species was investigated in vitro. Glucose absorption in mouse jejunum was highly inhibited (68.1%) by cytochalasin E (25.0 micrograms/ml) within 30-min incubation and less extent in rat (48.9%), hamster (34.1%), frog (28.1%), guinea pig (27.5%), rabbit (24.3%) and turtle jejunum (22.7%). Among cytochalasins A, B, C, D and E, cytochalasin E was a most potent derivative that could inhibit glucose absorption by up to 55.5% at a concentration of only 5.0 micrograms/ml in mouse jejunum and its effect may possibly be related to the formation of mini villi and the intracellular vacuoles in the intestinal absorptive cells.
D000818:Animals; D006224:Cricetinae; D003572:Cytochalasins / Q000494:pharmacology*; D003864:Depression, Chemical; D005947:Glucose / Q000378:metabolism*; D006168:Guinea Pigs; D007408:Intestinal Absorption / Q000187:drug effects*; D007700:Kinetics; D051379:Mice; D013045:Species Specificity
D003572:Cytochalasins; D005947:Glucose