title: [Digoxin therapy of chronic cardiac failure under control of its concentration in the blood].
abstract: The influence of digoxin concentration in blood on its therapeutic effect was studied in 59 patients with chronic circulatory insufficiency and cardiac fibrillation and in 89 patients with chronic circulatory insufficiency and sinus cardiac rhythm. The changes in blood digoxin concentration in patients with cardiac insufficiency complicated by cardiac fibrillation with maintained sinus cardiac rhythm both during the "saturation" period and during maintenance treatment were of the same type. The content of digoxin in the blood does not determine the potency of its therapeutic effect. The optimum therapeutic effect of digoxin in all patients with cardiac fibrillation and signs of cardiac insufficiency persists for quite a long period of time. Continuously used cardiac glycosides lose their inotropic effect in patients with sinus cardiac rhythm.
mesh_terms: D000328:Adult; D000368:Aged; D001146:Arrhythmia, Sinus / Q000188:drug therapy; D001281:Atrial Fibrillation / Q000188:drug therapy; D002908:Chronic Disease; D004077:Digoxin / Q000008:administration & dosage* / Q000097:blood; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D004077:Digoxin
vernacular_title: Terapiia khronicheskoĭ serdechnoĭ nedostatochnosti digoksinom pod kontrolem kontsentratsii ego v krovi.