Disintegration-dissolution analysis of percent dissolved-time data.
A simple, graphical method is described for the disintegration--dissolution analysis of cumulative percent dissolved--time data. The technique is based on a biexponential equation with the assumption of first-order disintegration and dissolution according to a simple dissolution model. The dissolution data obtained for six commercial tablets and capsules adequately fit the developed equation. The described method is simple and can handle initial data points that are usually ignored by other techniques.
D002214:Capsules; D002626:Chemistry, Pharmaceutical; D007700:Kinetics; D008956:Models, Chemical; D012995:Solubility; D013607:Tablets; D013997:Time Factors
D002214:Capsules; D013607:Tablets