Quantification of trabecular bone with low dose computed tomography.
Computed tomography (CT) has the potential of providing a precise quantification of trabecular bone. A special purpose low dose CT system for applications at peripheral measuring sites has been developed. With this system, the quantification of trabecular bone can be achieved with a reproducibility on the order of 0.3%. It has been used successfully in pilot studies of immobilization osteoporosis in children and adults on a week by week basis. Currently, the method is being used in a preliminary investigation of bone loss in women in an attempt to differentiate normal changes from changes due to postmenopausal osteoporosis. Results obtained so far indicate that intervals of 3 months are adequate for following the natural course of osteoporosis or its response to therapy on an individual basis.
D000328:Adult; D000368:Aged; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals; D010024:Osteoporosis / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods*
D008903:Minerals