Jaundice and wound healing: a tissue-culture study.
The effects of jaundice on wound healing have been studied by growing fibroblasts, in vitro, in normal culture media, in culture media to which bilirubin has been added, and in culture media containing sera from jaundiced patients. It has been found that the addition of bilirubin to the culture media causes morphological changes in the fibroblasts, and impairs the growth of cells. The addition of jaundiced human sera to the culture also causes similar changes.
D000328:Adult; D000368:Aged; D000818:Animals; D001663:Bilirubin / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003470:Culture Media; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D007565:Jaundice / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D051381:Rats; D014945:Wound Healing
D003470:Culture Media; D001663:Bilirubin