[Cephalexin pharmacokinetics].
The pharmacokinetics of cephalexin monohydrate after its oral administration in a single dose was studied on rats and dogs. The analysis of the pharmacokinetic data obtained with the one-compartmental model showed that the rate of the antibiotic absorption in the rats was higher than that in the dogs. The periods of the cephalexin half-absorption and maximum concentration were 0.2 and 1.1 hour in the rats and 0.64 and 1.9 hours in the dogs respectively. The period of the antibiotic half-life was almost the same in both animal species. Selective localization of cephalexin in the kidney and liver tissues was noted. The antibiotic was mainly excreted by the kidneys (98.8 per cent for 24 hours).
D000818:Animals; D001682:Biological Availability; D002506:Cephalexin / Q000378:metabolism*; D004285:Dogs; D007700:Kinetics; D008433:Mathematics; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D002506:Cephalexin
Farmakokinetika tsefaleksina.