[The stability of drugs under the conditions of the ultrasonic thermo aerosol (author's transl)].
Under conditions of the ultrasonic thermo aerosol the stability of selected drugs is investigated by estimation of their concentration and by spectrophotometric and thin-layer chromatographic analysis, respectively. Using an ultrasonic nebulizer USI 50 of the common production neither the spectrophotometric nor the thin-layer chromatographic analysis give any sign of destruction processes of the drugs used. As a rule the concentration of the drugs is lower in the condensed aerosol than in the stock solution. For clinical use this decrease in unimportant. Producing the stock solution of nystatin corresponding to the recommendations of the committee "Aerosols in the Medicine" of the Society of Bronchopneumonology and Tuberculosis of the GDR, only very low concentrations of nystatin can be detected in the aerosol. Producing the solution in another way--chosen by us--50% of the concentration in the stock solution can be fund in the aerosol. But this manner of production still needs the approval of the central expert evidence committee.
D000336:Aerosols / Q000032:analysis; D002855:Chromatography, Thin Layer; D006801:Humans; D012138:Respiratory Therapy / Q000379:methods*; D013053:Spectrophotometry; D014465:Ultrasonics
D000336:Aerosols
Zur Stabilität von Arzneimitteln unter Bedingungen des Ultraschall-Thermo-Aerosols (2. Mitteilung).