Changes in blood ketone body ratio: their significance after major hepatic resection.
Changes in the ratio of acetoacetate to 3-hydroxybutyrate (the ketone body ratio) in arterial blood were investigated after massive liver resection in patients and rabbits. In a patient who had had a successful hepatectomy, the blood ketone body ratio decreased rapidly after the operation and then returned to the preoperative level; whereas in a patient who had had an unsuccessful hepatectomy, the blood ketone body ratio did not decrease rapidly after the operation. In 70% hepatectomized rabbits, the blood ketone body ratio decreased maximally nine hours after hepatectomy and then returned gradually to a normal level. The blood ketone body ratio paralleled the hepatic energy charge after 70% hepatectomy in rabbits. The measurement of the blood ketone body ratio is very useful for evaluation of the energy status of the remnant liver.
D000090:Acetoacetates / Q000097:blood*; D000368:Aged; D000818:Animals; D001158:Arteries / Q000032:analysis; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism; D006498:Hepatectomy; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood*; D007657:Ketone Bodies / Q000097:blood*; D008099:Liver / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D010084:Oxidation-Reduction; D011184:Postoperative Period; D011817:Rabbits
D000090:Acetoacetates; D005227:Fatty Acids; D006885:Hydroxybutyrates; D007657:Ketone Bodies; D009243:NAD