Is glutamate a trigger factor in epileptic hyperactivity?
The effects of glutamate and aspartate antagonists were studied on limb-jerk frequency and EEG patterns in rats made epileptic by cobalt implantation in the sensorimotor cerebral cortex. The results of this study were as follows: (1) alpha-Amino-4-phosphonobutyric acid (0.055--1.10 mM) decreased or completely prevented the epileptic manifestations. The effect was reversible 30 min after washing with artificial CSF solution. (2) DL-Pyroglutamic acid completely abolished the myoclonic jerks and EEG spikes. (3) alpha-Amino-5-phosphonovaleric acid and alpha-D-amino-adipic acid significantly reduced the frequency of epileptic spikes and myoclonic jerks. (4) Other analogs, alpha-amino-3-phosphonopropionic acid (0.6 mM), alpha-amino phosphonocaproic acid (0.95), and hydroxy-3-amino pyrrolidone-2 were without effect. (5) Glutamate itself did not decrease the epileptic manifestations.
D000596:Amino Acids / Q000032:analysis; D000613:Aminobutyrates / Q000494:pharmacology; D000818:Animals; D001224:Aspartic Acid / Q000037:antagonists & inhibitors; D002540:Cerebral Cortex / Q000032:analysis; D004569:Electroencephalography; D004827:Epilepsy / Q000209:etiology* / Q000503:physiopathology; D018691:Excitatory Amino Acid Antagonists; D005260:Female; D005971:Glutamates / Q000502:physiology*; D009943:Organophosphorus Compounds / Q000494:pharmacology; D051381:Rats; D012640:Seizures / Q000209:etiology
D000596:Amino Acids; D000613:Aminobutyrates; D018691:Excitatory Amino Acid Antagonists; D005971:Glutamates; D009943:Organophosphorus Compounds; D001224:Aspartic Acid; C012729:2-amino-4-phosphonobutyric acid