title: Decreased retention of fatty acid conjugated DDT metabolites in rats given injections of heparin, bile salts or lecithin.
abstract: Intravenous injections of solutions of heparin, bile salts or lecithin into rats previously intraperitoneally injected with 14C-DDT significantly removed fatty acid conjugated 14C-DDT metabolites retained in their livers and spleens. These 14C-DDT metabolites comprised greater than 90 percent of the radioactivity present in these organs 10 days after the animals were first injected with 14C-DDT. The conjugation of DDT metabolites to fatty acids thus appears to be a primary mechanism by which DDT is ultimately retained in animals and possibly humans. Heparin, bile salts or lecithin might be used as clearing agents for removing these conjugates.
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology*; D003634:DDT / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D006493:Heparin / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008297:Male; D010713:Phosphatidylcholines / Q000494:pharmacology*; D051381:Rats; D013154:Spleen / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; D005227:Fatty Acids; D010713:Phosphatidylcholines; D006493:Heparin; D003634:DDT