title: [Structural and functional alterations of the mucosa of a jejunal segment, interposed isoperistaltically after total gastrectomy according to Longmire-Gütgeman (author's transl)].
abstract: Six patients had total gastrectomy because of carcinoma followed by jejunum isoperistaltic interposition according to Longmire. A jejunal biopsy was taken in every case during operation and three and six months later endoscopically for morphometric and functional evaluation of small bowel mucosa. Three months after the operation a rise of L-phenylalanin in vitro uptake, an increase in villus height, surface area and a deepening of the crypts with raised mitotic activity of the crypt cells was found. The ratio of villus height to crypt depth was increased, although not significantly. On the other hand the activity of sucrase was initially decreased. Six months postoperatively all parameters had become normal besides the disaccharidases. These changes may be due to adaptive mucosal hyperplasia after small bowel resection or to luminal mucosal damage followed by compensatory hyperregeneration. Finally a humoral stimulus for mucosal hyperplasia as a postoperative effect is discussed.
mesh_terms: D001706:Biopsy; D004186:Disaccharidases / Q000378:metabolism; D005743:Gastrectomy; D006801:Humans; D006965:Hyperplasia; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000473:pathology*; D007583:Jejunum / Q000473:pathology / Q000637:transplantation*; D008938:Mitosis; D010649:Phenylalanine / Q000378:metabolism; D011183:Postoperative Complications / Q000473:pathology*; D013274:Stomach Neoplasms / Q000601:surgery; D014182:Transplantation, Autologous
chemical_list: D010649:Phenylalanine; D004186:Disaccharidases
vernacular_title: Strukturelle und funktionelle Schleimhautveränderungen im Jejunuminterponat bei totaler Magenresektion nach Longmire-Gütgeman.