Influence of the "Corynebacterium parvum" vaccine and stilbostat on intratesticular development of Walker 256 carcinosarcoma in hyper- or hypothyroidized Wistar rats.
This work studies the effect of nonspecific antitumoral immunity produced by the "Corynebacterium Parvum" vaccine (C.P.) and Stilbostal on the development of Walker 256 carcinosarcoma intratesticularly grafted to hyper- or hypothyroidized Wistar rats. The thyroid hormone level was altered by administration of thyroxin, Alkiron or surgical thyroidectomy. The C.P. vaccine was given in a mixture with tumoral cells suspension and the treatment with the Stilbostat drug was started 5 days from grafting. The results show that C.P. administered in a mixture with tumoral cells suspension causes marked inhibition of the development of the primary tumor and metastasis, an effect which is not significantly influenced by the thyroid hormone level. The antitumoral effect of the Stilbostat drug is enhanced by administration of C.P. in tumoral cells suspension. The greatest effect produced by Stilbostal was noted in the hyperthyroidized lots in which the tumor was administered in a mixture with C.P.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001428:Bacterial Vaccines / Q000494:pharmacology*; D002279:Carcinoma 256, Walker / Q000378:metabolism* / Q000648:ultrastructure; D004054:Diethylstilbestrol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006980:Hyperthyroidism / Q000378:metabolism*; D007037:Hypothyroidism / Q000378:metabolism*; D008297:Male; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D011425:Propionibacterium acnes / Q000276:immunology*; D051381:Rats; D013736:Testicular Neoplasms / Q000378:metabolism*
D000970:Antineoplastic Agents; D001428:Bacterial Vaccines; D009588:Nitrogen Mustard Compounds; C009323:stilbostat; D004054:Diethylstilbestrol