Identification of N-monoacetylcystine in uraemic plasma.
1. An unidentified ninhydrin-positive substance of an acidic nature was detected in the plasma of uraemic patients. This substance was isolated from haemodialysate by ion-exchange chromatography and gel filtration, and identified as a sulphur-containing amino acid: N-monoacetylcystine. 2. The quantitative determination of sulphur amino acids in plasma revealed that the plasma levels of cysteic acid, homocysteic acid, taurine, cystine and cystathionine as well as N-monoacetylcystine in uraemic patients were markedly higher than in normal subjects (P less than 0.001 for each). However, the plasma levels of methionine in uraemic patients were within normal limits.
D000603:Amino Acids, Sulfur / Q000097:blood*; D003553:Cystine / Q000031:analogs & derivatives* / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood; D014511:Uremia / Q000097:blood*
D000603:Amino Acids, Sulfur; D003553:Cystine; C030905:N-monoacetylcystine