Cremophor and Emulphor induced alterations of serum lipids and lipoprotein electrophoretic patterns of dogs.
The effects of Cremophor and Emulphor, two polyethoxylated castor oil vehicles, on serum lipids and lipoproteins electrophoretic patterns were examined in beagle dogs. The vehicles were given as daily intravenous (i.v.) infusions of 0.5 ml/kg. Flushing of the skin, edematous wrinkling of the skin above the eyes and shaking of the head were observed during or shortly after each infusion of either vehicle. Thrombocytopenia occurred in Emulphor-treated dogs but increased platelet counts occurred in Cremophor-treated dogs. The spleen, lymph nodes, livers and kidneys all had excessive amounts of lipid present. There were increased serum levels of triglycerides, lipids, cholesterol and lipoproteins. Electrophoresis of sera revealed decreased alpha-lipoprotein fraction and the appearance of a new, as yet unidentified, peak near the origin. The lipid and lipoprotein changes were more marked in dogs treated with Cremophor. It appears that daily infusion with either vehicle results in changes in serum lipids, lipoprotein patterns and tissue lipid content.
D000818:Animals; D002784:Cholesterol / Q000097:blood; D002914:Chylomicrons / Q000097:blood; D004285:Dogs; D004586:Electrophoresis; D005260:Female; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D009821:Oils / Q000633:toxicity*; D011092:Polyethylene Glycols / Q000633:toxicity*; D014280:Triglycerides / Q000097:blood
D002914:Chylomicrons; D008055:Lipids; D008074:Lipoproteins; D009821:Oils; D014280:Triglycerides; C022131:cremophor; D011092:Polyethylene Glycols; D002784:Cholesterol