title: Pharmaco-ethological analysis of social behaviour of isolated mice.
abstract: The ethological profile of some neuropharmacological substances affecting catecholamines, serotonin and GABA was investigated in isolated mice. Changes in brain noradrenergic, dopaminergic or serotonergic systems, in addition to a block of the inhibitory GABA system, caused "irrepressible" aggression and a lack of sociability in isolated mice. GABA analogues (phenibut, phenylpyrrolidon) and GABA agonists reduce aggression and increase intraspecies sociability; small doses of GABA antagonists (picrotoxin, bicuculline) exert the opposite effect. GABA may play a key part in the control of aggression and sociability in isolated animals. Selective activation of intraspecies sociability with a concurrent reduction of species-specific aggression requires complex pharmacological action.
mesh_terms: D000818:Animals; D001337:Autonomic Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D002491:Central Nervous System Agents / Q000494:pharmacology*; D006224:Cricetinae; D008297:Male; D012702:Serotonin Antagonists / Q000494:pharmacology*; D012934:Social Isolation
chemical_list: D001337:Autonomic Agents; D002491:Central Nervous System Agents; D012702:Serotonin Antagonists