title: Effects of long-term lead exposure on monkey leukocyte chromosomes.
abstract: Cynomolgus monkeys (Macaca irus) received daily doses of 1 or 5 mg of lead for a period of 12 months. Samples of venous blood were taken at 0, 7, 9 and 12 months, and cultured lymphocytes were analysed for the presence of chromosome aberrations. A few severe chromosome aberrations, such as dicentrics or translocations, appeared in the control animals as well as in the lead-treated ones, during the course of the experiment. However, lead treatment increased significantly the frequency of chromosome and chromatid gaps, and this result is in agreement with other previous results.
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D007854:Lead / Q000633:toxicity; D007855:Lead Poisoning / Q000235:genetics*; D007962:Leukocytes / Q000187:drug effects* / Q000648:ultrastructure; D008252:Macaca fascicularis
chemical_list: D007854:Lead