The behaviour of tumour cells of ovarian carcinomata under in vitro conditions and the coincidence with clinical controllability of tumours.
The clinical significance of in vitro cytostatics testing, based on 96 patients with ovarian carcinomata over a 4-year period (1976-1979) is reported. Cell cultivation and short-time incubation are used for the purpose. The cytostatic effect are ascertained by microscopic comparative tests and determination of 3H-thymidine and -cytidine incorporation. The results obtained by in vitro methods coincide to about 70%. Ovarian carcinomata are most frequently sensitive to Adriblastin and least frequently to DTIC. The correlation rate between in vitro test results and clinical reality was 83%. The clinical significance of cytostatics testing in vitro consists in --the individualisation of the tumour chemotherapy, --the possibility of a prognostic estimate, --the ascertainment of causes of chemotherapy failure, --the prevention of useless therapeutic trials on the patient.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D008938:Mitosis / Q000187:drug effects; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D011379:Prognosis
D000970:Antineoplastic Agents