[Comparative clinical investigations on the cardiovascular effects of piritramide (dipidolor) and fentanyl (author's transl)].
In 36 patients with acquired heart disease effects of 0.15 mg/kg piritramide on hemodynamics, inotropic state and myocardial oxygen consumption were investigated during and after cardiac surgery (basic neuroleptanalgesia). It could be demonstrated, that piritramide is not inducing any negative inotropic effects compared to a control group (n = 36) and a fentanyl group (0.003 mg/kg, n = 31). There were only small changes in HR, SV, PRA and PLA. A slight decrease in Part, PLV, and arterial perfusion pressure during extracorporeal circulation is interpreted as a peripheral vasodilatation. The resulting decrease in heart work caused a significant decrease in myocardial oxygen consumption (-18%), which is of special advantage in patients with coronary heart disease.
D000768:Anesthesia, General; D001794:Blood Pressure / Q000187:drug effects; D004347:Drug Interactions; D005112:Extracorporeal Circulation; D005260:Female; D005283:Fentanyl / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007432:Intraoperative Period; D007540:Isonipecotic Acids / Q000494:pharmacology*; D008297:Male; D009458:Neuroleptanalgesia; D010101:Oxygen Consumption / Q000187:drug effects; D010892:Pirinitramide / Q000008:administration & dosage / Q000494:pharmacology*; D011184:Postoperative Period
D007540:Isonipecotic Acids; D010892:Pirinitramide; D005283:Fentanyl
Vergleichende klinische Untersuchungen von Herz-Kreislauf-Effekten zwischen Piritramid (Dipidolor) und Fentanyl.