Studies on new aminoglycoside antibiotics, istamycins, from an actinomycete isolated from a marine environment. I. The use of plasmid profiles in screening antibiotic-producing streptomycetes.
Plasmid profiles were used to screen streptomycetes for production of new antibiotics. Among about 100 strains isolated from sea muds, an isolate designated SS-939 was revealed to harbor several plasmids of different sizes, and to produce istamycins, new aminoglycoside antibiotics. Based on the characteristics of the strain, a new Streptomyces species is proposed: S. tenjimariensis.
D000617:Aminoglycosides / Q000096:biosynthesis; D000900:Anti-Bacterial Agents; D010957:Plasmids; D012623:Seawater; D013302:Streptomyces / Q000145:classification / Q000302:isolation & purification* / Q000378:metabolism; D014871:Water Microbiology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C022949:istamycins