[Gentamicin concentration in the blood and lung tissue of children with bronchopulmonary pathology].
The gentamicin levels in the lung tissue and blood serum of children operated on for bronchiectasis, destructive pneumonia and pleural tumors were studied. The antibiotic was administered intramuscularly in a dose of 3 mg/kg before the operation. The results showed that intramuscular injections of gentamicin provided the antibiotic levels in the lung tissue sufficient for the growth inhibition of the majority of the microbes isolated from such patients. In the patients with congenital developmental defects of the lungs, the level of the antibiotic in the lung tissue 1 hour after its administration was lower than the therapeutic one, while its blood serum levels were high. By the 2nd hour the gentamicin levels in the lung tissue reached those in the patients with acquired bronchopulmonary disease.
D000042:Absorption; D000293:Adolescent; D001987:Bronchiectasis / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005839:Gentamicins / Q000097:blood*; D006801:Humans; D007273:Injections, Intramuscular; D008168:Lung / Q000378:metabolism*; D010997:Pleural Neoplasms / Q000378:metabolism*; D011014:Pneumonia / Q000378:metabolism*; D013997:Time Factors
D005839:Gentamicins
Issledovanie kontsentratsii gentamitsina v syvorotke krovi i legochnoĭ tkani u deteĭ s bronkholegochnoĭ patologieĭ.