[Studies on iron metabolism and iron deficiency anemia in pregnant women--theoretical discussion on the relation between serum iron level and iron dose to be administrate, and clinical result after iron therapy (author's transl)].
Animal and clinical studies were performed in order to establish a criterion for diagnosis of iron-deficiency anemia and a standard dose of the intravenous iron treatment, based on properties of serum transferrin (Tr) in ironmetabolism during gestation. And the following results were obtained. 1) 59Fe-labelled large molecular colloid iron-solution (CSA-Fe) was injected in pregnant rats: the iron transferring to the fetuses originated from the mothers' serum iron isolated from CSA-Fe. 2) There was no difference of iron supplying abilities of Tr across to maternal and fetal tissues of rat, in anemia in the latter stage of gestation (A) and in non-pregnant iron-deficiency anemia (B), although there was significant difference in nature of Tr between rat and woman. 3) Tr of rat in A and in B: There was no difference in 59Fe-uptake into the rat reticulocytes from Tr between the two statuses. 4) In the clinical study, iron utilization rate was correlated with serum iron saturation rate both in A and B. 5) CSA-Fe was clinically given for A and B according to the original formulas, and utility of the formulas were confirmed.
D000747:Anemia, Hypochromic / Q000188:drug therapy / Q000378:metabolism*; D000818:Animals; D005260:Female; D005296:Ferrous Compounds / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000378:metabolism*; D011263:Pregnancy Trimester, Third; D051381:Rats; D014168:Transferrin / Q000378:metabolism
D005296:Ferrous Compounds; D014168:Transferrin; D007501:Iron