6-Hydroxydopamine and radiofrequency lesions of the lateral entorhinal cortex facilitate an operant appetitive conditioning task in mice.
The entorhinal cortex seems heterogeneous as dopaminergic terminals are present only in the anterior part of the lateral entorhinal cortex. In order to clarify the interaction of this cortex with the hippocampus in memory processes, the effects of either 6-hydroxydopamine or radiofrequency bilateral lesions were compared. Both lesions enhance the retention of a Skinner task with continuous reinforcement schedule. Involvement of dopamine in memory processes is discussed.
D000818:Animals; D001066:Appetite / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D003213:Conditioning, Psychological / Q000187:drug effects*; D006892:Hydroxydopamines / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011846:Radio Waves
D006892:Hydroxydopamines