Ultrastructure of elastosis in facial rhytidectomy skin.
Skin from 19 facial rhytidectomies performed in patients with chronic solar damage was compared with postauricular skin from patients of similar age. Light microscopy demonstrated large areas of amorphous material that stained PAS positive in all 19 face-lift specimens, while none of the controls had such material. Electron microscopy of the "elastotic" material revealed large amorphous masses of granular material, with loss of the microfilament component of normal elastin. Current theories suggest that the elastotic material in solar-damaged skin is a product of radiation-damaged fibroblasts, rather than being either collagen or degenerated elastin. Such knowledge may help the plastic surgeons encourage rhytidectomy patients to protect themselves from solar radiation.
D000368:Aged; D004547:Elastic Tissue / Q000473:pathology / Q000648:ultrastructure*; D005145:Face / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012867:Skin / Q000473:pathology / Q000528:radiation effects / Q000648:ultrastructure*; D013472:Sunlight; D013518:Surgery, Plastic