[Comparison of the effects of absorption of aminophenazone or propyphenazone combined with sodium nitrite on the incidence and early appearance of tumors in the rat].
Formation of nitrosamines, after absorption of nitrite and secondary or tertiary amines in the gastro-intestinal tract, is used as a chemical test of carcinogenicity in the Rat. We have confirmed the carcinogenic power of a tertiary amine association: aminophenazone, and sodium nitrite giving dimethyl-nitrosamine in Sprague Dawley rats: both substances are administered at low and high concentrations in drinking water. We have studied simultaneously, the propyphenazone/sodium nitrite association in the same experimental conditions without carcinogenic power: --treatment duration: thirty weeks, --study duration: two years with observation of carcinogenic reactions, --verification of data: control and substances given independently.
D000632:Aminopyrine / Q000633:toxicity*; D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000633:toxicity; D002273:Carcinogens; D004347:Drug Interactions; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009573:Nitrites / Q000633:toxicity*; D051381:Rats; D012977:Sodium Nitrite / Q000633:toxicity*
D002273:Carcinogens; D009573:Nitrites; D000632:Aminopyrine; D012977:Sodium Nitrite; C009077:propyphenazone; D000983:Antipyrine
Comparison des effets de l'absorption de l'aminophénazone ou de la propyphénazone associées au nitrite de sodium sur la fréquence et la précocité d'apparition de tumeurs chez le rat.