title: Effective immunization of lambs against enterotoxaemia.
abstract: In contrast to adult sheep, 2- to 3-month-old lambs do not respond well to a single injection of Clostridium perfringens Type D oil adjuvant epsilon toxoid. This unresponsiveness can be overcome, however, by administering 2 injections of oil adjuvant vaccine or one injection of oil adjuvant followed 4 weeks later by an injection of alum-precipitated toxoid. The latter procedure evokes protective antitoxin levels which persist for 8 months, and a booster injection of alum-precipitated toxoid given at this stage results in an immunity which lasts for at least 1 year.
mesh_terms: D000367:Age Factors; D000818:Animals; D000917:Antibody Formation; D001428:Bacterial Vaccines / Q000592:standards; D003013:Clostridium / Q000276:immunology; D003015:Clostridium Infections / Q000662:veterinary*; D004767:Enterotoxemia / Q000276:immunology / Q000517:prevention & control*; D007115:Immunization Schedule / Q000662:veterinary; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000517:prevention & control*; D013997:Time Factors; D014121:Toxoids / Q000592:standards
chemical_list: D001428:Bacterial Vaccines; D014121:Toxoids