Uterine relaxant effects of mono- and dibenzyloxyindanpropionic acids.
DIPA [5,6-bis(dibenzyloxy)-1-oxo-2-propyl-2-indanpropionic acid] and MIPA (5-benzyloxy-1-oxo-2-butyl-2-indanpropionic acid) were evaluated for relaxant effects on the estrogenized isolated rat uterus. In a concentration-dependent and reversible manner DIPA (10(-5)-3x10(-4)M) inhibited uterine contractions induced by PGF2 alpha, KCl and BaCl2, and MIPA (10(-5)-3x10(-4)M) inhibited the oxytocic effects of PGF2 alpha, PGE2, acetylcholine and BaCl2. Further evaluation of DIPA demonstrated its selectivity for uterine smooth muscle since it did not interfere with carbachol-induced increased tone nor isoproterenol-induced decreased tone of the isolated guinea pig trachea, nor did it inhibit the positive inotropic effects of isoproterenol on the isolated guinea pig atrium.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007189:Indans / Q000494:pharmacology*; D007192:Indenes / Q000494:pharmacology*; D009126:Muscle Relaxation / Q000187:drug effects; D010276:Parasympatholytics / Q000494:pharmacology*; D011460:Prostaglandins F / Q000037:antagonists & inhibitors*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects*
D007189:Indans; D007192:Indenes; D010276:Parasympatholytics; D011460:Prostaglandins F; D000644:Quaternary Ammonium Compounds; C001002:diisopropylamine dichloroacetate; C030800:5-benzyloxy-1-oxo-2-butyl-2-indan propionic acid