Immunobiological and pharmacological properties of thymus factor X (TFX). II. Immunotropic activity.
Immunobiological effect of the active thymus extract (preparation TFX) was evaluated in vitro. It was shown that the preparation exerts a protective effect, in relation to the cytotoxic action of hydrocortisone, and restores lymphocyte sensitivity to imuran in thymectomized mice. The findings show that preparation TFX has an activity corresponding to that of Goldstein's thymosin. The unit of immunotropic activity of TFX was introduced. Besides, cell-mediated reactions (skin test, MIF) displayed immunogenic properties of TFX.
D000818:Animals; D006168:Guinea Pigs; D007111:Immunity, Cellular / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D011817:Rabbits; D013947:Thymosin / Q000276:immunology; D013949:Thymus Extracts / Q000276:immunology*
D013949:Thymus Extracts; D013947:Thymosin