[Complex effect of K+ ions and viability inhibitors of tumor cells].
It is shown that NaCN, actinomycin D and sarcolysin damaged EAT cells, and the level of cell damage depended on K+ concentration in the incubation salt solution and the injury agent. With respect to NaCN the cell sensitivity was found to rise to a great extent when the cells were incubated in the presence of 143 mM K+. For actinomycin D and sarcolysin the effect of K+ ions was negligible.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003486:Cyanides / Q000494:pharmacology*; D003609:Dactinomycin / Q000494:pharmacology*; D007700:Kinetics; D008558:Melphalan / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology*; D012966:Sodium Cyanide / Q000494:pharmacology*
D003486:Cyanides; D003609:Dactinomycin; D012966:Sodium Cyanide; D008558:Melphalan; D011188:Potassium
Kompleksnoe deĭstvie ionov K+ i ingibitorov zhiznedeiatel'nosti na epukholevye kletki.