title: Graded dose effects of angiotensin II on aldosterone production in man during various levels of potassium intake.
abstract: This study was performed to evaluate the hypothesis that adrenal aldosterone output is modulated by daily potassium intake in man. Eight normotensive subjects, aged 24-38 yr, were fed 3 separate 150 mEq sodium-containing diets. Potassium content ranged from 300 mEq daily during the first week, to 80 mEq daily and 10 mEq daily for the subsequent 2 wk. On days 4 and 5 of each diet each subject took oral dexamethasone 0.5 mg B.I.D. to prevent endogenous ACTH secretion. On day 6 an infusion of angiotension II (AII) was administered in doses of 0.1, 0.3, 1.0, 3.0 and 10.0 ng/kg/min, each lasting 30 min. Blood pressure, pulse, and plasma aldosterone and potassium were measured throughout the infusions. All at infusion rates of 3 and 10 ng/kg/min, produced significant increases in plasma aldosterone values during liberal potassium intake but not when potassium intake was 10 mEq/day. We conclude that dietary potassium in man modulates All-mediated aldosterone secretion.
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood* / Q000652:urine; D000804:Angiotensin II / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D011188:Potassium / Q000008:administration & dosage* / Q000097:blood
chemical_list: D000804:Angiotensin II; D000450:Aldosterone; D011188:Potassium