Emergence of supraependymal cells in rat third ventricle after administration of p-chloroamphetamine.
Administration of single or multiple 10 mg/kg doses of parachloroamphetamine hydrochloride, a serotonin-neurotoxic drug, to adult male rats, leads to emergence of clusters of supraependymal cells in the third ventricle above the median eminence. Transmission EM of specimens previously examined with scanning electron optics reveals that the cell clusters have characteristics of neurons. Two weeks after the initial drug injection, the ventricular surfaces of some animals lack the cell clusters, suggesting a "transience" in their appearance. The neuron-like elements may appear in response to alterations in brain serotonin levels, and their presence suggests an ability of adult nerve cells to migrate in response to chemical changes in neural tissue or cerebrospinal fluid.
D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004805:Ependyma / Q000187:drug effects*; D008297:Male; D008473:Median Eminence / Q000187:drug effects; D008855:Microscopy, Electron, Scanning; D009412:Nerve Fibers / Q000187:drug effects; D009416:Nerve Regeneration / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D051381:Rats; D010133:p-Chloroamphetamine / Q000494:pharmacology*
D000662:Amphetamines; D010133:p-Chloroamphetamine