title: [Effects of a single dose of the mutant gene CatFr in mouse ontogeny].
abstract: A study of the lenses of CatFr/+ and +/+ mice at different stages of embryonic and postembryonic development by means of electron and light microscopy has shown that the effect of CatFr gene single dose is characterized by a more rapid denucleation of lens fibers, as compared with the normal development. Defects of the nuclear envelope structure, similar with those described earlier for homozygotes, were observed in the developing lenses of heterozygotes. In CatFr/+ mice, unlike in homozygotes, the nuclei of primary lens fibers are not practically affected but those of secondary fibers are destroyed, thus leading to the lysis of these fibers and the development of cataract. The expression of CatFr gene in heterozygotes is due to additive interaction of its effects and "denucleation" process.
mesh_terms: D000818:Animals; D002386:Cataract / Q000235:genetics* / Q000473:pathology; D005260:Female; D005799:Genes, Dominant; D006579:Heterozygote; D006720:Homozygote; D007908:Lens, Crystalline / Q000196:embryology / Q000254:growth & development / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008817:Mice, Mutant Strains / Q000235:genetics*; D008854:Microscopy, Electron
vernacular_title: Izuchenie éffektov odinarnoĭ dozy mutantnogo gena CatFr v ontogeneze myshi.