title: [On the behaviour of a one-component drug form during compression (author's transl)].
abstract: Using the Instron TT-M universal testing machine, the authors studied the deformation behaviour of noramido-pyrine methanesulphonate sodium (Analgin), in the form of a substance of varying particle size as well as in the form of granules and of a tablet mixture, during compression (static test). The parameters for the evaluation of compressibility were determined by means of the deformation curve obtained by recording the distance of the counter die and the pressure at constant deformation rate. The stress relaxation at constant deformation was determined by recording the relaxation pressure as a function of time for three nominal stress values (4, 8 and 16 kN). The granulation and the composition of the adjuvants exert a favourable effect on the deformation and relaxation properties of Analgin-substance. They also cause a marked plastic behaviour of the tablet mixture, which is beneficial to tabletting.
mesh_terms: D004177:Dipyrone; D004339:Drug Compounding; D005079:Excipients; D011312:Pressure; D013607:Tablets
chemical_list: D005079:Excipients; D013607:Tablets; D004177:Dipyrone
vernacular_title: Uber des Verhalten einer Einkomponenten-Arzneiform während des Pressens.