title: Metoclopramide. Management of gastrointestinal intolerance in rheumatoid arthritis patients.
abstract: Ten patients with rheumatoid arthritis who were unable to tolerate anti-inflammatory doses of non-steroidal anti-inflammatory drugs (NSAIDs) were admitted to the study. After endoscopy three patients were taken out of the study because of frank gastric ulceration. Seven patients entered the six-week study during which anti-inflammatory doses of NSAIDs were preceded by 30 minutes by a 10-mg dose of oral metoclopramide. The insults of this pilot study suggest that pretreatment with metoclopramide enables patients with rheumatoid arthritis who have non-ulcer dyspepsia to tolerate full dosage of NSAIDs.
mesh_terms: D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use*; D008875:Middle Aged; D011292:Premedication
chemical_list: D000893:Anti-Inflammatory Agents; D008787:Metoclopramide