title: A simple method for testing two-locus models of inheritance.
abstract: A graphic method for testing simple two-locus models of inheritance is developed. The model assumes two alleles at each locus where both loci exhibit dominant, both exhibit recessive, or one locus exhibits dominant and one locus exhibits recessive inheritance. Examples of applying the graphs using published data on three diseases are given.
mesh_terms: D000483:Alleles; D002446:Celiac Disease / Q000235:genetics; D005385:Fingers / Q000002:abnormalities; D005787:Gene Frequency; D006432:Hemochromatosis / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D010641:Phenotype; D011336:Probability