Anabolic steroids. Part 3: metabolism of ethylestrenol in rat liver preparations in vitro.
1. Ethylestrenol incubated with a post-mitochondrial supernatant fraction of rat liver plus co-factors gives norethandrolone as the major metabolite. 2. A second (minor) metabolite was tentatively identified as 17 alpha-ethyl-5 epsilon-estrane-3 epsilon,17 beta-diol. 3. A pathway is suggested for the metabolism of ethylestrenol in the rat.
D000818:Animals; D002849:Chromatography, Gas; D004958:Estradiol / Q000031:analogs & derivatives / Q000378:metabolism; D005032:Ethylestrenol / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D013058:Mass Spectrometry; D009639:Norethandrolone / Q000378:metabolism; D051381:Rats
D004958:Estradiol; C029869:17 alpha-ethyl-5 xi-estrane-3 xi,17 beta-diol; D005032:Ethylestrenol; D009639:Norethandrolone