The influence of a new antiarrhythmic drug, Craviten (M-71) on the circulatory system in cats.
Craviten, a newly synthesized ester of optically active 2-aminobutanol-1, produced in cats hypotension and inhibited excitability of sinus node and atrio-ventricular and intraventricular conduction. It acts as a spasmolytic on the isolated rabbit ileum, being approx. 100 times as potent as papaverine. Studies with drugs affecting the vegetative system indicate that the hypotensive and spasmolytic action of Craviten consists in a direct depressing action on smooth musculature.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D004562:Electrocardiography; D005029:Ethylenediamines / Q000494:pharmacology*; D005260:Female; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D012119:Respiration / Q000187:drug effects
D000889:Anti-Arrhythmia Agents; D005029:Ethylenediamines; C030706:butobendin; D001285:Atropine; D011433:Propranolol