Diuretic treatment and serum lipoproteins: effects of tienilic acid and indapamide.
Treatment with the commonly used diuretic, chlorthalidone, has previously been found to increase the serum low-density-lipoprotein cholesterol (LDL-C) fraction. Therefore, the effects of two new agents, tienilic acid (a combined diuretic-uricosuric) and indapamide on serum lipid and lipoprotein levels were assessed. Six weeks of treatment with tienilic acid, 250 mg/day, markedly decreased serum uric acid and significantly increased LDL-C and triglycerides in 16 men. In contrast, indapamide 2.5 mg/day, had no apparent influence on serum lipids or lipoproteins in 18 men.
D004232:Diuretics / Q000494:pharmacology*; D006016:Glycolates / Q000494:pharmacology*; D006801:Humans; D007190:Indapamide / Q000494:pharmacology*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D013989:Ticrynafen / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
D004232:Diuretics; D006016:Glycolates; D008074:Lipoproteins; D014280:Triglycerides; D007190:Indapamide; D013989:Ticrynafen