title: Rotary press utilizing a flexible die wall.
abstract: A die with a flexible wall was constructed and evaluated on a specially modified instrumented rotary tablet press. The design permits an inward deflection of the die wall by a side punch, which rolls past a side compression roll during compression-decompression. The side compression roll is instrumented to monitor the applied side compression roll forces. On decompression, return of the die wall to its original position permits release of residual die wall pressure. The decreased residual die wall pressure can decrease fracture and capping of tablets for problem formulations. The performance was tested on three experimental formulations. For these formulations, tablets made in a conventional die exhibited severe capping problems. However, most tablets compressed in the special die were superior. With proper adjustment of punch and die wall compression forces, excellent tablets could be manufactured. The merits of the special die and modified tablet machine are substantiated, although this initial design did not provide adequate die wall pressure for all formulations. Further engineering efforts could result in practical production equipment.
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage; D001205:Ascorbic Acid / Q000008:administration & dosage; D005079:Excipients; D010615:Phenacetin / Q000008:administration & dosage; D011312:Pressure; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000295:instrumentation*
chemical_list: D005079:Excipients; D013607:Tablets; D000082:Acetaminophen; D010615:Phenacetin; D001205:Ascorbic Acid