title: Differential inhibition of ketogenesis by malonyl-CoA in mitochondria from fed and starved rats.
abstract: Rates of ketogenesis in mitochondria from fed or starved rats were identical at optimal substrate concentrations, but responded differently to inhibition by malonyl-CoA. Kinetic data suggest that the K1 for malonyl-CoA is greater in the starved animal. These results indicate that, for the regulation of ketogenesis in the starved state, the lower sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA may be more important than the concentration of malonyl-CoA.
mesh_terms: D000214:Acyl Coenzyme A / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D007657:Ketone Bodies / Q000096:biosynthesis*; D007700:Kinetics; D008297:Male; D008316:Malonyl Coenzyme A / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013217:Starvation / Q000378:metabolism*
chemical_list: D000214:Acyl Coenzyme A; D007657:Ketone Bodies; D008316:Malonyl Coenzyme A