Bovine serum albumin humoral immune response in aged Fischer 344 rats.
The circulating antibody titers to bovine serum albumin (BSA) were determined for two groups of aged Fischer 344 rats obtained form the National Institute on Aging. One group received a single immunization of BSA in complete Freund's adjuvant, and the second group was immunized three times at two-week intervals with twice the antigen dosage. An age difference was observed during the peak response in both groups, the younger rats having higher titers; however, upon multiple injections the older rats show an enhanced response although significantly lower than the younger rats. All antibody titers increased at the same rate, yet measurable antibody always appeared first in younger animals.
D000375:Aging; D000818:Animals; D000917:Antibody Formation; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344 / Q000276:immunology*; D011919:Rats, Inbred Strains / Q000276:immunology*; D012710:Serum Albumin, Bovine / Q000276:immunology*
D012710:Serum Albumin, Bovine