title: Observations on preadipocytes and their distribution patterns in rat adipose tissue.
abstract: Microscopic examination of adipocytes isolated from adult rat epididymal adipose tissue revealed numerous small cells (less than 10 micron) morphologically similar to larger adipocytes. These small adipocytes appear identical to a new classification of adipose cells termed preadipocytes. Electron micrographs of these preadipocytes revealed examples of cells less than 10 micron in diameter in various stages of maturation and lipid accumulation. The percent distribution pattern of these small adipocytes was not significantly altered by exercise although exercise shifted the distribution patterns of the larger cells (greater than 30 micron) toward a smaller mean cell size. The quantitative significance of preadipocytes is not established but these preliminary observations indicate that adipocytes less than micron in diameter may account for a numerically greater proportion of the total adipocytes observed in collagenase isolated preparations than heretofore recognized, although their contribution to total adipose mass is probably negligible.
mesh_terms: D000273:Adipose Tissue / Q000166:cytology / Q000648:ultrastructure*; D000818:Animals; D004822:Epididymis / Q000033:anatomy & histology; D008297:Male; D008854:Microscopy, Electron; D005082:Physical Exertion; D051381:Rats / Q000033:anatomy & histology*