[Evaluation of the protective effect of gamma-hydroxybutyric acid in stress].
Administration of GHBA during emotional stress reduces the stress syndrome that manifests in the lesser increase of the corticosterone content in blood plasma, while the noradrenaline level in the heart remains unchanged. GHBA prevents necrosis and contracture injuries of heart muscle cells during the stress. Quantitative evaluation of GHBA protective effect on the organism exposed to stress helped determine that the preliminary administration of GHBA reduces twofold the time necessary for the appearance of eosinophilia after eosinopenia. This indicates that GHBA a powerful antistress action.
D000818:Animals; D009202:Cardiomyopathies / Q000517:prevention & control; D003345:Corticosterone / Q000097:blood; D004804:Eosinophils; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D007958:Leukocyte Count; D008297:Male; D009206:Myocardium / Q000032:analysis; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D012978:Sodium Oxybate; D013312:Stress, Physiological / Q000097:blood / Q000150:complications / Q000188:drug therapy*
D006885:Hydroxybutyrates; D012978:Sodium Oxybate; D003345:Corticosterone; D009638:Norepinephrine
Otsenka zashchitnogo éffekta gamma-oksimaslianoĭ kisloty pri stresse.