[Effect of pyridoxal-5-phosphate on epileptic activity in the cerebral cortex].
It has been shown in acute experiments on cats that pyridoxal-5-phosphate (PALPh) injected intravenously in doses of 5-20 mg/kg suppresses the epileptic activity in solitary foci caused by penicillin and strychnine local application as well as in the complex of loci created in different zones of the brain cortex. Under the influence of PALPh the complex was destabilized and suppressed, and the epileptic activity first disappeared in the dependent foci and then in a determinant one. It is concluded that PALPh has antiepileptic activity. This effect seems to be more pronounced in the penicillin-induced epileptic foci.
D000818:Animals; D000927:Anticonvulsants; D001921:Brain / Q000378:metabolism; D002415:Cats; D002540:Cerebral Cortex / Q000503:physiopathology*; D004594:Electrophysiology; D010406:Penicillins / Q000037:antagonists & inhibitors; D011732:Pyridoxal Phosphate / Q000627:therapeutic use*; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D013331:Strychnine / Q000037:antagonists & inhibitors; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000927:Anticonvulsants; D010406:Penicillins; D005680:gamma-Aminobutyric Acid; D011732:Pyridoxal Phosphate; D013331:Strychnine
Vliianie piridoksal-5-fosfata na épilepticheskuiu aktivnost' v kore golovnogo mozga.