[Experimental study of the dynamics in the biochemical parameter changes in the oxytetracycline biosynthesis process in apparatus of varying capacity].
An increase in the input of the mechanical power speeds up the culture growth, which correlates with the rate of carbohydrate and nitrogen consumption during the first phase of the process, the time of the biosynthesis phase onset and the level of the antibiotic production during this phase. During the second half of the process the antibiotic biosynthesis markedly decreases, especially in the apparatus with a high input of the mechanical power. Deficiency in carbon and nitrogen is one of the causes of this decrease. The activity level at the end of the biosynthesis in such apparatus does not differ significantly, since it depends on the biosynthesis rate during the whole cultivation period.
D050260:Carbohydrate Metabolism; D005285:Fermentation; D009584:Nitrogen / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D010118:Oxytetracycline / Q000096:biosynthesis*; D013302:Streptomyces / Q000378:metabolism; D013997:Time Factors
D009584:Nitrogen; D010100:Oxygen; D010118:Oxytetracycline
Eksperimental'noe izuchenie dinamiki izmeneniia biokhimicheskikh parametrov v protsesse biosinteza oksitetratsiklina v apparatakh razlichnogo masshtaba.