Anodic migration of actin and increased levels of a cathodic fibronectin among the cytoskeletal changes that correlate with increased cell adherence in liver epitheloid tumor cells.
Liver epitheloid tumor cells exposed to iododeoxyuridine revealed increased resistance to detachment from their growth substratum when exposed to low levels of EDTA. Two-dimensional analysis of the Triton-X-100 insoluble cytoskeleton from cells grown with iododeoxyuridine revealed an increased level of cathodic fibronectin and a more anodic migration of actin-like components concurrent with the reduced expression of an anodic 50K component and of a cathodic 60K component.
D000199:Actins / Q000502:physiology*; D000818:Animals; D002277:Carcinoma / Q000473:pathology / Q000503:physiopathology*; D002448:Cell Adhesion / Q000187:drug effects; D004594:Electrophysiology; D005353:Fibronectins / Q000502:physiology; D007065:Idoxuridine / Q000494:pharmacology; D008113:Liver Neoplasms / Q000473:pathology / Q000503:physiopathology*; D051381:Rats
D000199:Actins; D005353:Fibronectins; D007065:Idoxuridine