Somatomedin generating activity of the 20,000-dalton variant of human growth hormone.
The 20,000-dalton variant of human growth hormone stimulated production of somatomedins in the hypophysectomized rat. Somatomedin activity was measured by a radioreceptor assay. The results indicate that the insulin--like activities of human growth hormone that are greatly diminished in the variant are not prerequisites for somatomedin production.
D000818:Animals; D001681:Biological Assay; D014644:Genetic Variation; D013006:Growth Hormone / Q000235:genetics*; D006801:Humans; D007016:Hypophysectomy; D008297:Male; D008970:Molecular Weight; D051381:Rats; D011919:Rats, Inbred Strains; D013002:Somatomedins / Q000096:biosynthesis* / Q000097:blood / Q000494:pharmacology
D013002:Somatomedins; D013006:Growth Hormone