A comparison of the vasoconstrictor effects of angiotensin II and angiotensin III in the canine renal vasculature.
The effects of angiotensin II and angiotensin III on systemic blood pressure and renal blood flow were studied in pentobarbital anesthetized dogs pretreated with phenoxybenzamine. Angiotensin II was more potent than angiotensin III in increasing systemic blood pressure when given intravenously. When angiotensin II and angiotensin III were administered directly into the renal artery, angiotensin II was also more potent than angiotensin III as a renal vasoconstrictor. Indomethacin potentiated the responses to angiotensin II and angiotensin III to the same extent. The results indicate that differential vasoconstrictor effects of the two peptides in renal vasculature contribute to the difference in potency of intravenously administered peptides on systemic blood pressure, and also suggest that vasodilator prostaglandins are involved in the vasoconstrictor properties of the two peptides in the renal vasculature of the dog.
D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000805:Angiotensin III / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004347:Drug Interactions; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D007668:Kidney / Q000098:blood supply*; D008297:Male; D012039:Regional Blood Flow / Q000187:drug effects; D014662:Vasoconstrictor Agents
D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D000805:Angiotensin III; D007213:Indomethacin