[Intramitochondrial changes in adenocarcinoma cells of the uterine mucosa following progesterone therapy].
In cells of human endometrial carcinoma intramitochondrial inclusions were found. After treatment with large doses of progesterone majority of them disintegrated and severe lesion of the mitochondria developed. The mechanism of the mitochondrial alterations in tumour cells induced by progesterone is not yet cleared, however a primary membrane lesion can not be excluded. It is believed, that this damage to mitochondria may play a part in the regression of endometrial carcinoma induced by progesterone.
D004717:Endometrium / Q000187:drug effects* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008931:Mitochondria, Muscle / Q000648:ultrastructure*; D011374:Progesterone / Q000494:pharmacology*; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000648:ultrastructure*
D011374:Progesterone
Intramitokondriális változások a méhnyálkahártya adenocarcinoma sejtjeiben progresztatív kezelés után.