Finger clubbing and aspartylglucosamine excretion in a laxative-abusing patient.
A young woman with a previous history of anorexia nervosa presented with severe finger clubbing. Urine samples intermittently contained significant amounts of aspartylglucosamine. Liver biopsy showed abnormal cytoplasmic inclusions in phagocytic cells. The patient was found to be abusing senna laxative.
D000328:Adult; D000581:Amidohydrolases / Q000652:urine*; D000856:Anorexia Nervosa; D001227:Aspartylglucosylaminase / Q000652:urine*; D002400:Cathartics / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000139:chemically induced*; D012676:Senna Extract / Q000009:adverse effects*; D019966:Substance-Related Disorders / Q000150:complications
D002400:Cathartics; D012676:Senna Extract; D000581:Amidohydrolases; D001227:Aspartylglucosylaminase