Adjuvant activity of carbohydrate analogs of N-acetylmuramyl-L-alanyl-D-isoglutamine on the induction of delayed-type hypersensitivity to azobenzenearsonate-N-acetyl-L-tyrosine in guinea pigs.
The adjuvant activity of 29 kinds of carbohydrate analogs of N-acetylmuramyl-L-alanyl-D-isoglutamine on the induction of delayed-type hypersensitivity to azobenzenearsonate-N-acetyl-L-tyrosine was examined in guinea pigs. It was found that the D-manno- and D-galacto-type muramyldipeptides were as active as the D-gluco-type muramyldipeptide (MDP). The structural requirement of the carbohydrate moiety of analogs of N-acetylmuramyl-L-alanyl-D-isoglutamine is discussed.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000276:immunology*; D000276:Adjuvants, Immunologic; D000818:Animals; D001391:Azo Compounds / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006020:Glycopeptides / Q000276:immunology*; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014443:Tyrosine / Q000009:adverse effects / Q000031:analogs & derivatives*; D010132:p-Azobenzenearsonate / Q000009:adverse effects* / Q000031:analogs & derivatives
D000276:Adjuvants, Immunologic; D001391:Azo Compounds; D006020:Glycopeptides; C000234:azobenzenearsonate-N-acetyl-L-tyrosine; D014443:Tyrosine; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D010132:p-Azobenzenearsonate