Relationship of inferior olive-climbing fibers to p,p'-DDT-induced myoclonus in rats.
The effects of 3-acetylpyridine (3-AP), which destroys the inferior olive, and harmaline, which stimulates inferior olive-climbing fiber activity, on DDT-induced myoclonus, wee studied in rats. 3-AP shortened and harmaline delayed the time of onset of myoclonus after intragastric administration of DDT. 3-AP also counteracted the antimyoclonic action of L-5-hydroxytryptophan plus chlorimipramine, clonazepam and phenoxybenzamine in this animal model. The results suggest that these antimyoclonic agents require an intact olivocerebellar pathway for their action.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D003634:DDT; D006246:Harmaline / Q000494:pharmacology; D008297:Male; D009207:Myoclonus / Q000139:chemically induced / Q000503:physiopathology*; D009847:Olivary Nucleus / Q000187:drug effects / Q000503:physiopathology*; D011725:Pyridines / Q000494:pharmacology; D051381:Rats
D000927:Anticonvulsants; D011725:Pyridines; C010835:3-acetylpyridine; D003634:DDT; D006246:Harmaline