Induction of lesions of selenium-vitamin E deficiency in ducklings fed silver, copper, cobalt, tellurium, cadmium, or zinc: protection by selenium or vitamin E supplements.
In 3 experiments, 684 newly hatched White Pekin ducklings were fed (for 15 to 28 days) a commercial starter mash that was adequate in selenium and vitamin E (Se-E) content, either alone or with supplements of Ag (3,000 mg/kg of feed, as acetate), Cu (1,500 mg/kg, as sulfate), Co (200 or 500 mg/kg, as chloride), Te (500 mg/kg, as tetrachloride), Cd (100 or 500 mg/kg, as sulfate), Zn (3,000 or 6,000 mg/kg, as sulfate), or V (100 mg/kg, as vanadate). The ducklings fed Ag, Cu, Co, Te, Cd, and Zn frequently developed lesions characteristic of Se-E deficiency, such as necrosis of skeletal and cardiac muscle and of smooth muscle of the gizzard and intestine. Complete protection from the muscle lesions produced by Cu, Co, Te, Cd, and Zn supplements was provided by vitamin E (200 IU of alpha-tocopherol acetate/kg) and Se (2 mg/kg, as selenite). Ducklings fed Ag were protected by supplements of vitamin E and partial protection was achieved by Se addition. The birds fed excessive Zn developed pancreatic necrosis and fibrosis that was not prevented by supplements of Se or vitamin E. Terminally, blood glutathione peroxidase activity was low and hepatic Se concentration was increased in the ducklings fed Ag. However, neither blood glutathione peroxidase activity nor hepatic Se concentrations was consistently abnormal in ducklings fed other trace elements, although lesions of Se-E deficiency were often present in these animals.
D000818:Animals; D002104:Cadmium / Q000009:adverse effects; D003035:Cobalt / Q000009:adverse effects; D003300:Copper / Q000009:adverse effects; D004032:Diet; D004372:Ducks; D008297:Male; D009132:Muscles / Q000473:pathology; D011201:Poultry Diseases / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D012643:Selenium / Q000627:therapeutic use*; D012834:Silver / Q000009:adverse effects; D013691:Tellurium / Q000009:adverse effects; D014131:Trace Elements / Q000009:adverse effects*; D014810:Vitamin E / Q000627:therapeutic use*; D014811:Vitamin E Deficiency / Q000139:chemically induced / Q000517:prevention & control / Q000662:veterinary*; D015032:Zinc / Q000009:adverse effects
D014131:Trace Elements; D002104:Cadmium; D014810:Vitamin E; D003035:Cobalt; D012834:Silver; D003300:Copper; D012643:Selenium; D015032:Zinc; D013691:Tellurium