Platelet-bound IgG in systemic lupus erythematosus with and without thrombocytopenia.
A new assay for IgG bound to autologous platelets is described, in which IgG is dissociated from platelets washed at low pH, then measured by radioimmunoassay. Platelet-bound IgG was found to be elevated in thrombocytopenic patients with SLE and reduced in non-thrombocytopenic patients with this disease. There was a close inverse correlation of platelet-bound IgG and platelet count. Immune complexes did not interfere with the assay.
D000936:Antigen-Antibody Complex; D001379:Azathioprine / Q000627:therapeutic use; D001666:Binding Sites, Antibody; D001792:Blood Platelets / Q000378:metabolism*; D006801:Humans; D007074:Immunoglobulin G; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D008775:Methylprednisolone / Q000627:therapeutic use; D010956:Plasmapheresis; D010976:Platelet Count; D011239:Prednisolone / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000150:complications
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D011239:Prednisolone; D001379:Azathioprine; D008775:Methylprednisolone