Effects of prostaglandin synthesis inhibitors on the anterior pituitary cell proliferation.
The effects of indomethacin and aspirin on the mitotic incidence in the anterior pituitary in male rats was investigated. It was shown that either of the inhibitors of prostaglandin synthesis used in the study suppressed the anterior pituitary mitotic activity, although the effect of indomethacin was more pronounced. A suppression of the mitotic activity involved the acidophilic and the chromophobe cells, whereas the number of basophils in mitosis was not diminished. These findings suggest an involvement of prostaglandins in the control of the anterior pituitary cell proliferation.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D008938:Mitosis / Q000187:drug effects*; D010903:Pituitary Gland, Anterior / Q000166:cytology* / Q000187:drug effects; D051381:Rats
D001241:Aspirin; D007213:Indomethacin