UDP-glucose effect on phrenic diaphragm preparation of the rat.
The effects of uridine-5'-diphosphoglucose (UDPG) on the contractile response of the phrenic nerve-diaphragm preparation and on carbohydrate metabolism in the diaphragmatic muscle were studied in the rat. In the preparations obtained form rats, the contracturant action of UDPG, previously observed in guinea-pig preparations, was thus confirmed. This action was compared with those of uridine, UMP and UDP. Uridine alone was ineffective, while the higher concentration of both UMP and UDP induced a contracture comparable with that shown for the lower concentration of UDPG. This indicates that the action of UDPG is partially related at least to one phosphate-group into its molecular structure. In addition, several substrates and intermediates related to carbohydrate metabolism (glycogen, glucose, glucose-6-phosphate) were measured in the diaphragm, their concentrations proving unaffected by UDPG perfusion.
D000818:Animals; D050260:Carbohydrate Metabolism; D003964:Diaphragm / Q000187:drug effects; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009132:Muscles / Q000378:metabolism; D010791:Phrenic Nerve / Q000187:drug effects; D051381:Rats; D014532:Uridine Diphosphate Glucose / Q000494:pharmacology*; D014539:Uridine Diphosphate Sugars / Q000494:pharmacology*
D014539:Uridine Diphosphate Sugars; D014532:Uridine Diphosphate Glucose