Restoration by normal human immunoglobulin G of deficient serum opsonization for Streptococcus pneumoniae in sickle cell disease.
Supplementation of sera from four children with sickle cell disease with untreated or heated normal human serum or with normal human immunoglobulin G restored opsonic activity for serotype 10 Streptococcus pneumoniae, whereas supplementation with normal human immunoglobulin M did not.
D000755:Anemia, Sickle Cell / Q000276:immunology*; D002675:Child, Preschool; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology; D008297:Male; D009895:Opsonin Proteins / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology*; D013789:Thalassemia / Q000276:immunology
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009895:Opsonin Proteins