Sulfhydryl compounds may mediate gastric cytoprotection.
Ethanol induces hemorrhagic gastric erosions and causes a dose-dependent decrease in the concentration of nonprotein sulfhydryl compounds in rat gastric mucosa. Sulfhydryl-containing drugs protect rats from ethanol-induced gastric erosions, whereas sulfhydryl blocking agents counteract the mucosal cytoprotective effect of prostaglandin F2 beta. These observations suggest that endogenous nonprotein sulfhydryls may mediate prostaglandin-induced gastric cytoprotection and that sulfhydryl drugs may have potential for preventing or treating hemorrhagic gastric erosions.
D000818:Animals; D000431:Ethanol / Q000037:antagonists & inhibitors; D005753:Gastric Mucosa / Q000187:drug effects*; D011453:Prostaglandins / Q000502:physiology; D011460:Prostaglandins F / Q000494:pharmacology; D051381:Rats; D013438:Sulfhydryl Compounds / Q000502:physiology*; D013439:Sulfhydryl Reagents / Q000494:pharmacology*
D011453:Prostaglandins; D011460:Prostaglandins F; D013438:Sulfhydryl Compounds; D013439:Sulfhydryl Reagents; D000431:Ethanol