Microwave radiation (2450 MHz) alters the endotoxin-induced hypothermic response of rats.
The parenteral administration of bacterial endotoxin to rats causes a hypothermia that is maximal after approximately 90 minutes. When endotoxin-injected rats were held in a controlled environment at 22 degree C and 50% relative humidity and exposed for 90 minutes to microwaves (2450 MHz, CW) at 1 mW/cm2, significant increases were observed in body temperature compared with endotoxin-treated, sham-irradiated rats. The magnitude of the response was related to power density (10 mW/cm2 greater than 5 mW/cm2 greater than 1 mW/cm2). Saline-injected rats exposed for 90 minutes at 5 mW/cm2 (specific absorption rate approximately 1.0 mW/g) showed no significant increase in body temperature compared with saline-injected, sham-irradiated rats. The hypothermia induced by endotoxin in rats was also found to be affected by ambient temperature alone. Increases in ambient temperature above 22 degree C in the absence of microwaves caused a concomitant increase in body temperature. This study reveals that subtle microwave heating is detectable in endotoxin-treated rats that have impaired thermoregulatory capability. These results indicate that the interpretation of microwave-induced biological effects observed in animals at comparable rates and levels of energy absorption should include a consideration of the thermogenic potential of microwave.
D000064:Acclimatization; D000818:Animals; D001831:Body Temperature / Q000187:drug effects / Q000528:radiation effects*; D004731:Endotoxins / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D008872:Microwaves; D051381:Rats; D013997:Time Factors
D004731:Endotoxins; D008070:Lipopolysaccharides