Chromosome changes in human lymphocytes after separate and combined treatment with divalent salts of lead, cadmium, and zinc.
Unstimulated human lymphocytes in whole blood were treated for three hours with lead, cadmium, and zinc acetate separately and in combinations of two or three metal salts with different concentrations of between 10(-3) and 10(-5) moles, respectively. Untreated cultures and sodium acetate-treated samples served as controls. Chromosome analysis from 48 cultures revealed higher incidences of chromatid-type aberrations and gaps only for cultures exclusively treated with cadmium. The results are discussed under the respect of heavy metal metabolism in human lymphocytes.
D002104:Cadmium / Q000633:toxicity*; D002842:Chromatids / Q000187:drug effects; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007854:Lead / Q000633:toxicity*; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure*; D015032:Zinc / Q000633:toxicity*
D002104:Cadmium; D007854:Lead; D015032:Zinc