Genetic analysis of renal function in mice. 1. Glomerular filtration rate and its correlation with body and kidney weight.
Investigation of 18 inbred and 6 F1 hybrid mouse strains has shown that the glomerular filtration rate, bodyweight and kidney weight showed strain- and sex-dependent differences. Covariance analysis showed stronger correlations (genetic and environmental) between glomerular filtration rate and bodyweight than between glomerular filtration rate and kidney weight. This was predominantly due to a high within-strain variation of kidney weight (56%) in male mice. Therefore an allometric regression was calculated between the 48 strain means of glomerular filtration rate (GFR) and bodyweight (BW): GFR = 0.036 x BW0.74. Thus the term BW0.74, a suitable correction term for comparing the heat production of different species, is also suitable for the correction of glomerular filtration rate within one species.
D000704:Analysis of Variance; D000818:Animals; D000830:Animals, Laboratory; D001835:Body Weight; D004777:Environment; D005260:Female; D005919:Glomerular Filtration Rate / Q000662:veterinary*; D006824:Hybridization, Genetic; D007668:Kidney / Q000033:anatomy & histology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000033:anatomy & histology / Q000235:genetics / Q000502:physiology*; D009929:Organ Size; D012737:Sex Factors