[Mechanism of action of etimizol on the energy metabolism of the neurogenically damaged myocardium].
Ethimizol in a dose of 10 mg/kg prevents the decrease of calcium and creatine phosphate content in the myocardium of rats exposed to electrical stimulation. The drug was shown to exert a stimulant action on the heart adenyl cyclase system. It is suggested that the action mode of ethimizol on myocardial energy metabolism is connected with an activation of the adenyl cyclase system followed by the increased plasma membrane cell permeability by calcium ions.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000032:analysis; D009202:Cardiomyopathies / Q000188:drug therapy* / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D005042:Etimizol / Q000627:therapeutic use*; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D009206:Myocardium / Q000032:analysis / Q000378:metabolism*; D010725:Phosphocreatine / Q000032:analysis; D051381:Rats
D007093:Imidazoles; D010725:Phosphocreatine; D000262:Adenylyl Cyclases; D005042:Etimizol; D002118:Calcium
Issledovanie mekhanizma deĭstviia étimizola na énergeticheskiĭ obmen miokarda pri neĭrogennom ego povrezhdenii.