Se-75-labeled bile acid analogs, new radiopharmaceuticals for investigating the enterohepatic circulation.
Four selenium-labeled free bile acids and four selenium-labeled conjugated bile acids, labeled with Se-75 at the C-19, C-22, C-23, or C-24 position, have been synthesized and their absorption and excretion compared with that of [24-14C]cholic acid, following both oral and intravenous administration. All but one of the compounds is absorbed and excreted in bile to a significant extent. One compound, SeHCAT, has been selected for particular study. It is quantitatively absorbed from the gut at the same rate as cholic acid, and both are excreted into the bile at the same rate. It remains almost entirely confined to the enterohepatic circulation (the gut, liver, and biliary tree) and excretion is exclusively fecal. Whole-body retention, measured for 41 days, and tissue distributions suggest that the absorbed radiation dose would be small compared with that in many established tests. Such a compound offers the possibility of a simple, novel, and aesthetically acceptable method of investigating small-bowel disease. It therefore merits further investigation.
D000284:Administration, Oral; D000818:Animals; D001646:Bile / Q000032:analysis; D001647:Bile Acids and Salts / Q000378:metabolism*; D004764:Enterohepatic Circulation; D005243:Feces / Q000032:analysis; D007275:Injections, Intravenous; D007553:Isotope Labeling; D008657:Metabolic Clearance Rate; D011868:Radioisotopes / Q000378:metabolism*; D051381:Rats; D012643:Selenium / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution
D001647:Bile Acids and Salts; D011868:Radioisotopes; D012643:Selenium