Continual monitoring of the reactivation effect of oximes on blood acetylcholinesterase in the rats poisoned with organophosphates.
Acetylcholinesterase activity in rat blood was continuously monitored following O-ethyl-S-(2-dimethylaminoethyl)-methylphosphonothioate intoxication (p.o.) alone and in combination with atropine and the reactivators trimedoxime, obidoxime and methoxime. Decrease of acetylcholinesterase activity was not influenced by atropine alone but following treatment with a combination of atropine with the reactivators mentioned, an increase (reactivation) of the blood enzyme was demonstrated. This increase was highest for the combination atropine-trimedoxime and the lowest for the combination atropine-obidoxime.
D000110:Acetylcholinesterase / Q000097:blood*; D000122:Acetylthiocholine / Q000378:metabolism; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002801:Cholinesterase Reactivators; D005260:Female; D062025:Organophosphate Poisoning; D010091:Oximes / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D002801:Cholinesterase Reactivators; D010091:Oximes; D000122:Acetylthiocholine; D001285:Atropine; D000110:Acetylcholinesterase