Effects of awareness and motor involvement on autonomic conditioning in chronic schizophrenics.
Chronic schizophrenics under neuroleptic medication were compared with normals, matched for age and education, in two conditioning experiments. Both experiments employed a differential paradigm with long conditional stimulus--unconditional stimulus (CS-UCS) intervals. Skin resistance (SR) and finger pulse or heart rate (HR) were recorded. In Experiment 1, half of the subjects were trained in categorizing the to-be conditional stimuli. In a further step, half of the subjects were informed about the CS-UCS contingency. The UCS was an electric shock. Information improved discrimination of SR responses only of normals, and discrimination training had no effect at all on autonomic responses. In Experiment 2, only electrodermal responders were included. Each subject was tested in two sessions, using a loud tone as UCS in one, and a reaction time signal in the other. Again, half of the subjects wee informed about the contingency. Information improved discrimination of SR responses of both diagnostic groups. Decelerations of HR following CS onset showed informed schizophrenics to discriminate better with the loud tone UCS than with the reaction time signal. General autonomic responsivity seems to determine not only discriminative conditioning of schizophrenic patients but also the reports of awareness and the effects of manipulations of awareness. However, when subjects are matched for electrodermal responsivity and are equivalent in terms of SR response conditioning, patients react to information about the contingency with enhanced HR deceleration to the CSs, possibly reflecting a heightened sensitivity of the cardiovascular system.
D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology*; D003214:Conditioning, Classical; D004597:Electroshock; D005260:Female; D005712:Galvanic Skin Response; D006339:Heart Rate; D006358:Hot Temperature; D006801:Humans; D008875:Middle Aged; D010897:Pitch Discrimination; D012119:Respiration; D012559:Schizophrenia / Q000503:physiopathology*