[Fibrous lipid plaque formation in young people].
The study of the fibrous lipid plaque formation in young subjects showed that the proliferation of the smooth muscle cells in the arterial wall intima was the primary process in the genesis of the atherosclerotic lesions. The hypoxic alterations and metabolic deterioration of the vascular wall occur at the sites of the proliferation of smooth muscle cells and focal hyperplasia. This results in the obesity of the smooth muscle cells and increased permeability for plasma proteins, which intensifies even more the focal intimal sclerosis. The necrosis and degradation of the smooth muscle cells "overloaded" with fat in the centre of the plaque result in the release of lipids into the extracellular space and in the formation of atheroma. Further progressing of atheroma occurs due to the involvement of the new "foamy" and smooth muscle cells, located in its periphery, but not due to the immediate lipid deposition from the arterial lumen.
D000293:Adolescent; D000328:Adult; D000375:Aging; D001011:Aorta / Q000503:physiopathology; D001161:Arteriosclerosis / Q000209:etiology* / Q000503:physiopathology; D002463:Cell Membrane Permeability; D002648:Child; D005260:Female; D006025:Glycosaminoglycans / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology; D009336:Necrosis
D006025:Glycosaminoglycans; C020341:glucosaminoglycans
Formirovanie fibrozno-lipidnoĭ bliashki u lits molodogo vozrasta.