A stem-line model for cellular and chromosomal differentiation in early mouse-development.
Differentiation in mouse embryo development is represented formally by means of a stem-line model in which: 1. Individual choices are structured so that only a fraction of the cells of a given population receive a signal to undergo a change of state that results in a departure from the stem line. 2. Development proceeds by a series of restrictions in potency of all the cells in the stem line. 3. The stem line harbours the germ cells. 4. The germ cells are returned to a state of totipotency by some event(s) leading to meiosis.
D000818:Animals; D001757:Blastomeres / Q000166:cytology; D002454:Cell Differentiation; D004475:Ectoderm / Q000166:cytology; D004622:Embryo, Mammalian / Q000166:cytology*; D004707:Endoderm / Q000166:cytology; D005260:Female; D005854:Germ Cells / Q000166:cytology*; D008297:Male; D008540:Meiosis; D051379:Mice; D008954:Models, Biological; D012730:Sex Chromosomes / Q000502:physiology*; D013724:Teratoma / Q000209:etiology; D014327:Trophoblasts / Q000166:cytology; D014960:X Chromosome / Q000502:physiology*