Experimental endocarditis caused by Streptococcus sanguis: single and combined antibiotic therapy.
The effectiveness of penicillin G, fosfomycin, and cefoxitin alone and in combination was studied in vitro and in the treatment of left-sided Streptococcus sanguis endocarditis in rabbits. In vitro, the combinations penicillin G plus fosfomycin, penicillin G plus cefoxitin, and fosfomycin plus cefoxitin were synergistic or partially synergistic for S sanguis. Therapy with the combinations was more effective in eradicating the species from cardiac vegetations that was that with each antibiotic used alone.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002440:Cefoxitin / Q000627:therapeutic use*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D005260:Female; D005578:Fosfomycin / Q000627:therapeutic use*; D006801:Humans; D010400:Penicillin G / Q000627:therapeutic use*; D011817:Rabbits; D013290:Streptococcal Infections / Q000188:drug therapy*; D013298:Streptococcus sanguis / Q000187:drug effects
D000900:Anti-Bacterial Agents; D005578:Fosfomycin; D002440:Cefoxitin; D010400:Penicillin G