Synthesis and pharmacological properties of 1,2,3,4,5,6-hexahydro-1,6-methano-2-benzazocines.
1,2,3,4,5,6-Hexahydro-1,6-methano-2-benzazocine, 2'-methoxy-1,2,3,4,5,6-hexahydro-1,6-methano-2-benzazocine, and N-alkyl derivatives of 2'-hydroxy-1,2,3,4,5,6-hexahydro-1,6-methano-2-benzazocine have been synthesized in order to evaluate their analgesic activities. These compounds show only slight antinociceptive activities in the mouse hot-plate assay.
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D003496:Cyclazocine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D013329:Structure-Activity Relationship
D000700:Analgesics; D003496:Cyclazocine