Sister chromatid exchange in aplastic anemia.
The incidence of sister chromatid exchanges (SCE) in the lymphocytes of patients with aplastic anemia (AA) was determined before and after exposure to mitomycin C (MMC). The "baseline" SCE rate was significantly higher in AA, but MMC-induced SCE rate was not different compared to controls. It is suggested that some patients with AA may have an underlying DNA damage.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000235:genetics* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003078:Colchicine / Q000494:pharmacology; D003434:Crossing Over, Genetic; D005260:Female; D006801:Humans; D007223:Infant; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D012854:Sister Chromatid Exchange
D003078:Colchicine