Seizures and dermatitis after exposure to caprolactam.
A 22-year-old man was initially seen with dermatitis, fever, and seizures after three days of occupational exposure to caprolactam, a nylon fiber precursor. A comprehensive neurological investigation showed no organic CNS abnormalities. Although caprolactam has been shown to induce convulsive disorders in experimental animals, to our knowledge, there are no reports of caprolactam-induced seizures in man. The coincidence of typical skin lesions with otherwise unexplained grand mal seizures in this strongly suggests that caprolactam was the cause.
D000328:Adult; D001381:Azepines / Q000009:adverse effects*; D002209:Caprolactam / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000209:etiology*; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced*; D012640:Seizures / Q000139:chemically induced*; D012867:Skin / Q000473:pathology
D001381:Azepines; D002209:Caprolactam