[The treatment of housedustmite-allergy-three years' experience with hyposensitization with D.pteronyssinus-Preparations (D.P.) (author's transl)].
A group of 88 patients has been treated with D.P-hyposensitization for various allergic diseases ranking from rhinopathic to severe asthmatic symptoms. They all had a typical case history, showed a +++positive skintest reaction to D.P. plus at least a class-two RAST. Furthermore a scratchtest with dustsamples collected in the patients' home was performed and on positive reactions the items concerned (pillows, carpets, matraces etc.) were removed or replaced. Patients with multiple allergies or other complicating diseases were not evaluated in this study. All patients were treated with Allpyral-Semi-Depot preparations of D.P., by subcutaneous injections. Of 25 patients whose treatment is finished by now, all showed relief of their symptoms, 20 of them are free of symptoms 21/2 up to 18 months after end of treatment. Only 5 have shown recidives so far, which disappeared again when treatment was continued. The total PNU-dose applied averaged 8700 PNU per patient, with a maximum of 22800 PNU. The first signs relief showed when (an average of) 870 PNU were applied; at an average of 3000 PNU, patients for the first time were free of symptoms. Total treatment time varied from 6 to 16 months. No correlation was found between sex, age of the patient, or intensity or duration of the symptoms and the total PNU-dose needed for relief. Based on correct indication, hyposensitization with D.P. extracts today can be as successful as hyposensitization treatment in pollenallergies.
D000485:Allergens / Q000008:administration & dosage; D001249:Asthma / Q000628:therapy; D003888:Desensitization, Immunologic / Q000379:methods*; D004391:Dust; D006801:Humans; D007279:Injections, Subcutaneous; D008925:Mites / Q000276:immunology*; D012130:Respiratory Hypersensitivity / Q000628:therapy*; D013997:Time Factors
D000485:Allergens; D004391:Dust
Die Behandlung der Hausstaubmilbenallergie: Drei Jahre Erfahrung mit Semidepotextrakten von Dermatophagoides pteronyssinus (DP).