[Effect of regulating blood clotting with heparin and its antagonists on mast cells].
The paper concerns the effect of heparin and its antagonists, protamine and 2,5-ionen, on mast cell population from the standpoint of its potential action on blood coagulation. It has been established that intravenous administration of heparin is accompanied by its deposition in mast cells, that gives rise to rapid excretion of the anticoagulant from the blood flow. It has been also shown that protamine sulfate and 2,5-ionen produce degranulation of mast cells, but the synthetic polycation is superior over protamine sulfate in binding heparin of extracellular granules. Retaining of the increased saturation of mast cells with heparin on neutralization of the anticoagulant effect with protamine forms a structural basis for the origination of recurrent heparinemia. Study of blood coagulation has shown that 2,5-ionen is a more efficacious heparin antagonist than protamine sulfate.
D000768:Anesthesia, General; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D003594:Cytoplasmic Granules / Q000187:drug effects; D004285:Dogs; D006493:Heparin / Q000494:pharmacology*; D006494:Heparin Antagonists / Q000494:pharmacology*; D006591:Hexobarbital; D008407:Mast Cells / Q000187:drug effects*; D011073:Polyamines / Q000008:administration & dosage / Q000494:pharmacology; D011108:Polymers / Q000008:administration & dosage / Q000494:pharmacology; D011479:Protamines / Q000008:administration & dosage / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000008:administration & dosage / Q000494:pharmacology; D011817:Rabbits
D006494:Heparin Antagonists; D011073:Polyamines; D011108:Polymers; D011479:Protamines; D000644:Quaternary Ammonium Compounds; C037043:2,5-ionene; D006493:Heparin; D006591:Hexobarbital
Vliianie reguliatsii svertyvaniia krovi geparinom i ego antagonistami na tuchnye kletki.