The kindled seizure: production of and modification by dieldrin in rats.
In the rat dieldrin can evoke a progressive increase in the severity of convulsive responses (kindling) during repetitive exposures that cannot be attributed to simple accumulation of dieldrin in the brain. It can also replace pentylenetetrazol as a kindling stimulus in previously pentylenetetrazol-kindled rats (cross-kindling). Chronic exposure to dieldrin facilitates kindling produced by daily electrical stimulation of the amygdala. Even single, acute exposure, can facilitate kindling produced by electrical stimulation of the amygdala, 1 to 3 weeks later. We propose that the procedure of kindling is a useful one with which to assess neurotoxicity. Agents affecting kindling in laboratory animals are of particular concern to those individuals in a population with demonstrable seizure susceptibility, those predisposed to convulsive disorders and others vulnerable to increased levels of CNS excitability.
D000679:Amygdala / Q000502:physiology; D000818:Animals; D004026:Dieldrin / Q000378:metabolism / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D010433:Pentylenetetrazole / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D004026:Dieldrin; D010433:Pentylenetetrazole