Neural mechanisms of tardive dyskinesia.
Tardive dyskinesia is a disabling movement disorder, caused by antipsychotic medications, that occurs frequently and is not responsive to treatment. It is not known how the brain damage underlying tardive dyskinesia produces abnormal movement. We propose that altered sensory flow to motor systems results in this syndrome. Verification of such a mechanism could lead to early detection and improved treatment of tardive dyskinesia.
D001921:Brain / Q000503:physiopathology*; D004409:Dyskinesia, Drug-Induced / Q000453:epidemiology / Q000503:physiopathology*; D005724:Ganglia / Q000503:physiopathology; D006801:Humans; D009043:Motor Activity; D009044:Motor Cortex / Q000503:physiopathology