The effect of orally administered prostaglandins on gastric mucus secretion in the rat.
The secretion of gastric mucus may play a role in the protective effect of prostaglandins against gastric ulcers. To investigate the effect of prostaglandins E1, E2, F1alpha, F2alpha, A1, A2 and 15 (S) 15 methyl prostaglandin E2-methyl ester on gastric mucus secretion, these prostaglandins were given orally to rats at doses of 0.1, 1.0 and 4.0 mg/kg. The anthrone method was used to analyze the amount of mucus washed from the stomach with 2 M Nacl. Gastric secretory volume effects were also observed. All of the compounds tested increased both gastric mucus and secretory volume. The most active compound was 15(S)15 methyl PGE2 Me ester. The mucus stimulating effect of these prostaglandins, when administered locally, may be relevant to the understanding of the anti-ulcer effect of prostaglandins.
D000284:Administration, Oral; D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009093:Mucus / Q000378:metabolism*; D011465:Prostaglandins, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control
D011465:Prostaglandins, Synthetic