Enhancement of detrusor reflex activity by naloxone in patients with chronic neurogenic bladder dysfunction. Preliminary report.
An intravenous injection of 0.4 mg. naloxone enhanced detrusor reflex activity in 5 patients with chronic neurogenic bladder dysfunction caused by incomplete suprasacral spinal lesions. The intravesical volume at which detrusor reflex occurred showed a decrease from 498.2 to 346.2 ml. The naloxone-induced effect was short-lived, being absent 1 hour after the injection. In the same dosage naloxone did not induce detrusor reflex in 2 patients with areflexic bladder caused by complete suprasacral spinal lesions.
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects*; D013268:Stimulation, Chemical; D001743:Urinary Bladder / Q000187:drug effects* / Q000294:innervation; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy*
D009270:Naloxone