[Effect of pyrroxan and methylapogalanthamine on cerebral circulation and the brain's oxygen regime].
It has been shown in experiments on anesthetized animals under conditions of stabilized and non-stabilized perfusion pressure in the carotid arteries that effect of pirroksan and methylgalanthamine on the cerebral blood flow depends to a certain measure on changes in general arterial blood pressure. The cerebral blood flow and brain tissue oxygen consumption do not essentially change under the action of pirroksan whereas methylgalanthamine reduces the cerebral blood flow and brain tissue oxygen consumption. A possible mechanism of this effect is suggested.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004146:Dioxanes / Q000494:pharmacology*; D004147:Dioxins / Q000494:pharmacology*; D005702:Galantamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010100:Oxygen / Q000032:analysis; D010101:Oxygen Consumption / Q000187:drug effects*; D011759:Pyrrolidines / Q000494:pharmacology
D000959:Antihypertensive Agents; D004146:Dioxanes; D004147:Dioxins; D011759:Pyrrolidines; D005702:Galantamine; C013604:methylapogalanthamine; D010100:Oxygen; C009143:proroxan
Vliianie pirroksana i metilapogalantamina na krovoobrashchenie i kislorodnyĭ rezhim golovnogo mozga.