[Studies on the possible influence of oxamethacin upon DNA synthesis, DNA reparation and the supercoiled structure of DNA is spleen cells of mice].
The action of Oxamethacin on the DNA metabolism in spleen cells of mice was investigated with "in vitro" and "in vivo" experiments. An in vitro incubation of cells with 1 microgram Oxamethacin/ml did not influence the replicative DNA synthesis. 10 micrograms/ml however inhibited 50% of DNA synthesis. Oxamethacin dispensed in vivo did not show this inhibition. DNA repair after UV as well as after gamma irradiation was not influenced by this substance. Also the reconstitution of the supercoiled form of the DNA after different damages was not affected by Oxamethacin.
D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D004260:DNA Repair / Q000187:drug effects*; D004278:DNA, Superhelical; D066298:In Vitro Techniques; D007213:Indomethacin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D051379:Mice; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013936:Thymidine / Q000494:pharmacology
D004278:DNA, Superhelical; C019028:oxamethacin; D004247:DNA; D013936:Thymidine; D007213:Indomethacin
Untersuchungen über einen möglichen Einfluss von Oxametacin auf DNA Synthese, DNA Reparatur und die Supercoiled Struktur der DNA in Mausmilzzellen.