Specific cerebrovascular localization of glutamate decarboxylase activity.
Glutamate decarboxylase (GAD) activity and GABA levels, determined with a [3H]muscimol radioreceptor assay, were found to be significantly higher in cerebral blood vessels from the piaarachnoid membrane as compared to extracranial vessels (aorta, mesenteric and femoral arteries, and vena cava). A cerebrovascular localization for GABA and GAD is consistent with earlier studies suggesting that an indigenous GABA system is involved in cerebral vascular function.
D000818:Animals; D001011:Aorta / Q000201:enzymology; D001921:Brain / Q000201:enzymology; D002262:Carboxy-Lyases / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D005263:Femoral Artery / Q000201:enzymology; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D008638:Mesenteric Arteries / Q000201:enzymology; D011817:Rabbits; D051381:Rats; D014684:Venae Cavae / Q000201:enzymology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D002262:Carboxy-Lyases; D005968:Glutamate Decarboxylase