The coexistence of rheumatoid arthritis with Reiter's syndrome and/or ankylosing spondylitis: a model of dual HLA-associated disease susceptibility and expression.
In a prospective study of 184 patients with ankylosing spondylitis and/or Reiter's disease, we have examined the frequency of concomitant rheumatoid arthritis (RA) and determined the HLA profile of these patients. Five men (2.7%), 3 with ankylosing spondylitis and 2 with Reiter's disease, had coexistent classical RA and 2 of these also had Felty's syndrome. Immunogenetic analysis demonstrated that all 5 patients had either HLA-R27 or another B-7-cross-reactive antigen and that 3 also possessed HLA-DR4. Thus, 2 or more HLA-associated genetic predispositions may occur in the same individual, and, when expressed, result in the dual expression of both a spondylitic disease and RA.
D000293:Adolescent; D001741:Black or African American; D016918:Arthritis, Reactive / Q000150:complications* / Q000235:genetics / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000235:genetics / Q000276:immunology; D004198:Disease Susceptibility / Q000276:immunology*; D005258:Felty Syndrome / Q000150:complications; D006680:HLA Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D013167:Spondylitis, Ankylosing / Q000150:complications* / Q000235:genetics / Q000276:immunology; D044465:White People
D006680:HLA Antigens