Urinary protein profiles in patients with urothelial bladder tumours.
Urinary protein profiles were studied in 32 patients with urothelial bladder tumours, using immunonephelometry. In patients without residual or recurrent tumours a glomerular type of proteinuria was demonstrated. In patients with grade III-IV transitional cell carcinoma the glomerular proteinuria was more severe than in patients with grade I-II tumours. Increased excretion of low molecular weight proteins was observed only in patients with grade III-IV tumours. The use of the increased relative clearance of albumin, transferrin, and haptoglobin as a diagnostic test was attempted in detecting residual or recurrent tumours. In patients with grade III-IV tumours the predictive value of a positive or negative test was 92% and 100% respectively, whereas the relative protein clearance was without predictive value in patients with grade I-II tumours.
D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000209:etiology; D002295:Carcinoma, Transitional Cell / Q000150:complications* / Q000175:diagnosis / Q000652:urine; D005260:Female; D006242:Haptoglobins / Q000652:urine; D006801:Humans; D007136:Immunoglobulins / Q000652:urine; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000209:etiology*; D014168:Transferrin / Q000652:urine; D001749:Urinary Bladder Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000652:urine
D006242:Haptoglobins; D007136:Immunoglobulins; D014168:Transferrin