A non-invasive gamma-camera technique for the measurement of intrarenal flow distribution in man.
1. A new method, based on the transit time of omicron-iodohippurate sodium (Hippuran) through the kidney, is proposed as an accurate non-invasive means of measuring the intrarenal flow distribution in man. 2. Data from [123I]Hippuran gamma-camera renography are utilized in this method which employs region of interest selection, deconvolution, cross-correlation and curve subtraction to obtain the spectrum of transit times through the cortical and juxtamedullary nephrons. 3. In 12 normal subjects the mean percentage cortical flow was 83.9% (SEM 0.7%) which is approximately the anatomical proportion of cortical nephrons in the human kidney. 4. Cortical flow as a percentage of total was significantly reduced in 21 hypertensive patients, all of whom had no evidence of primary renal disease (mean 74.6%, SEM 1.5%). 5. In both the normotensive and hypertensive groups there was a good correlation between the results obtained from the left and right kidneys of the same patient showing the parallel physiological response of the two kidneys (mean difference 4%, P less than 0.001). 6. Reduction in the distribution of flow to the cortical nephrons in the essential hypertensive patients supports the hypothesis that renal autoregulation is important in this syndrome.
D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D007672:Kidney Cortex / Q000098:blood supply / Q000000981:diagnostic imaging; D008722:Methods; D011877:Radionuclide Imaging; D012079:Renal Circulation
D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid