Intestinal cholesterol uptake from mixed micelles. In vitro effects of taurocholate, taurochenodeoxycholate and tauroursodeoxycholate.
Cholesterol uptake by everted rat jejunal sacs is lower from mixed micelles containing tauroursodeoxycholate than from those with taurocholate or taurochenodeoxycholate. This occurs in spite of a greater saturation with cholesterol of tauroursodeoxycholate micelles as measured by equilibrium solubility studies. The results suggest that cholesterol saturation of solutions containing tauroursodeoxycholate is overestimated when calculated with reference to solubility in micellar form.
D000818:Animals; D002635:Chenodeoxycholic Acid / Q000031:analogs & derivatives*; D002784:Cholesterol / Q000378:metabolism*; D066298:In Vitro Techniques; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008823:Micelles; D051381:Rats; D012995:Solubility; D013655:Taurochenodeoxycholic Acid / Q000494:pharmacology*; D013656:Taurocholic Acid / Q000494:pharmacology*
D008823:Micelles; D002635:Chenodeoxycholic Acid; D013655:Taurochenodeoxycholic Acid; D013656:Taurocholic Acid; C031655:ursodoxicoltaurine; D002784:Cholesterol