Influence of body temperature on the set-up and recovery of noise-induced cochlea damage.
Hypothermia during exposure to noise reduced hair-cell damage which, on the contrary, was prevented from recovering by narcosis and hypothermia. Hyperthermia is apparently able to eliminate the narcosis dependent limitation of metabolism. A noise damage happens to develop by decompensating the excessively overburdened metabolism, whereas recovery seems to depend on the availability of a highly intracellular level of biological energy.
D000161:Acoustic Stimulation; D000818:Animals; D001831:Body Temperature; D003055:Cochlear Microphonic Potentials; D004734:Energy Metabolism; D005072:Evoked Potentials, Auditory; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000503:physiopathology; D006317:Hearing Loss, Noise-Induced / Q000503:physiopathology*