Kainic acid induced lesion of ventral tegmental area: locomotor effect of apomorphine.
Kainic acid induced lesion of dopaminergic ventral tegmental area (KA-A10) result in a permanent behavioral syndrome in the rat in which locomotor hyperactivity is the most typical symptom. Apomorphine in low doses (0.125 and 0.25 mg/kg i.p.) was as active as haloperidol (0.25 mg/kg i.p.) in abolishing this locomotor hyperactivity while higher doses of apomorphine were less active. The KA-A10 lesion is discussed as a model of mesolimbic/mesocortical dopaminergic hyperactivity.
D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D006220:Haloperidol / Q000008:administration & dosage / Q000037:antagonists & inhibitors; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*
D011759:Pyrrolidines; D011954:Receptors, Dopamine; D006220:Haloperidol; D001058:Apomorphine; D007608:Kainic Acid