Structure - activity relationships in 1,4-benzodiazepines.
The antipentylenetetrazole activity of 35 benzodiazepines has been quantitatively correlated, according to the Hansch model, to the physico-chemical parameters of the substituents. The activities, in the series of compounds under examination, appear to be correlated in a quantitative way to the overall lipophilicity of the molecules and to the presence of highly electron-withdrawing substituents in positions 7 and 2'.
D000927:Anticonvulsants; D001569:Benzodiazepines; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D012044:Regression Analysis; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D001569:Benzodiazepines; D010433:Pentylenetetrazole