Identification and determination of tele-methylhistamine in cerebrospinal fluid by gas chromatography-mass spectrometry.
The presence of tele-methylhistamine in human cerebrospinal fluid has been established. The concentration was determined with the use of deuterated tele-methylhistamine. The preparation of the deuterated standard is described. The concentration range in samples from neuropsychiatric patients was 0.1--2.5 ng/ml. The structure of the pentafluoropropionyl derivative used for gas chromatography was studied with the aid of proton nuclear magnetic resonance spectroscopy.
D002648:Child; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D007223:Infant; D009682:Magnetic Resonance Spectroscopy; D008761:Methylhistamines / Q000134:cerebrospinal fluid*; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid; D011618:Psychotic Disorders / Q000134:cerebrospinal fluid
D008761:Methylhistamines; C020404:tele-methylhistamine