Induction of lymphocyte differentiation by epidermal cultures.
Human and murine lymphoid cell populations were induced to express terminal deoxynucleotidyl transferase, a marker of early lymphoid differentiation, by exposure to allogeneic or syngeneic epidermal cells. Control growth medium, fibroblasts, or a mammary epithelial cell line did not induce this marker. These findings suggest that epidermal cells can induce lymphoid cell differentiation in vitro.
D000818:Animals; D002478:Cells, Cultured; D004253:DNA Nucleotidylexotransferase / Q000032:analysis*; D004254:DNA Nucleotidyltransferases / Q000032:analysis*; D004817:Epidermis / Q000201:enzymology / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000201:enzymology / Q000502:physiology*; D051379:Mice
D004254:DNA Nucleotidyltransferases; D004253:DNA Nucleotidylexotransferase