[Pharmacological analysis of the effect of homovanillic acid on rat behavior].
It was established in experiments on male Wistar rats that the dopamine metabolite homovanillic acid (HVA) injected into the lateral ventricle exerted opposite effects on the behavior depending on the dose used. HVA in doses of 25-50 microgram exerted an inhibitory effect on locomotor activity and orienting response. Larger doses of HVA (200-300 microgram) markedly increased locomotor activity. Application of the drugs selectively altering the central catecholaminergic activity made it possible to show that the inhibitory effect of HVA could be related as regards its influence to the presynaptic catecholamine receptors. The stimulant effect of larger doses of HVA is mediated via direct mimetic action on postsynaptic dopamine receptors.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006719:Homovanillic Acid / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010648:Phenylacetates / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects; D011954:Receptors, Dopamine / Q000187:drug effects
D010648:Phenylacetates; D011941:Receptors, Adrenergic; D011954:Receptors, Dopamine; D006719:Homovanillic Acid
Farmakologicheskiĭ analiz deĭstviia gomovanilinovoĭ kisloty na povedenie krys.