Effect of ambient cold on urine concentration by the intact and denervated dog kidney.
In dogs transferred from room temperature to a low temperature of 1 +/- (SD) 3.5 degree C, the plasma norepinephrine (NE) level increased significantly. Urine concentration decreased in the cold, in the intact and similarly in the chronically denervated kidney. After return to a warm environment urine concentration improved in both kidneys while plasma NE remained elevated. The data speak against an essential role of the renal function to ambient cold.
D000818:Animals; D003080:Cold Temperature; D003714:Denervation; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate; D007668:Kidney / Q000187:drug effects / Q000294:innervation / Q000502:physiology*; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D014556:Urine
D011433:Propranolol; D010646:Phentolamine