[In-vitro block of granulocyte chemotaxis with attenuated measles virus].
Live attenuated measles virus preparations, which are in use today in the prophylaxis against measles, were added in vitro to neutrophils from healthy children with negative history both for measles infection and vaccination. After incubation at 37 degree C for 30 min, and washing in Hank's solution, chemotaxis was assayed in Sykes-Moore chambers. Bacterial endotoxin and sera from healthy donors were used to stimulate motility. A significant decrease in chemotaxis was shown by virus-incubated neutrophils as compared to controls. These findings demonstrate that the attenuated measles virus preserves the same ability to inhibit neutrophil chemotaxis than the wild one, during the infection by which an in vivo defective chemotaxis has been previously described. It is suggested that some interference(s) of the virus may occur directly in the cell and/or its membrane receptors.
D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D066298:In Vitro Techniques; D008458:Measles Vaccine / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects; D014613:Vaccines, Attenuated / Q000494:pharmacology
D008458:Measles Vaccine; D014613:Vaccines, Attenuated
Blocco "in vitro" della chemiotassi granulocitaria mediato da virus attenuato del morbillo.