Manic depression--a disorder of central dopaminergic rhythm.
Starting from the fact that there are abnormal sweat K+ /Na+ ratios in both manics and depressives an attempt has been made to explain manic depression in terms of a disorder of the circadian rhythm of the adrenal glands. This, in turn, it is suggested, is caused by a defective circadian rhythm of central dopamine brought about by its having an abnormal response to ambient temperature change.
D000109:Acetylcholine / Q000378:metabolism; D000450:Aldosterone / Q000378:metabolism; D001714:Bipolar Disorder / Q000209:etiology / Q000503:physiopathology*; D002940:Circadian Rhythm; D002980:Climate; D003866:Depressive Disorder / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D011188:Potassium / Q000032:analysis; D012621:Seasons; D012964:Sodium / Q000032:analysis; D013542:Sweat / Q000032:analysis
D000450:Aldosterone; D012964:Sodium; D000109:Acetylcholine; D011188:Potassium; D004298:Dopamine; D006854:Hydrocortisone