Mutation-rate determinations based on electrophoretic analysis of laboratory mice.
Rate calculations are described for germinal mutations detected by an electrophoretic system as applied to mice in a series of recent experiments. The utility of the electrophoretic system is examined from several comparative viewpoints. The electrophoretic approach has a number of features to recommend it for future applications concerned with genetic hazard assessment. Its advantages include sensitivity, versatility, cost effectiveness and relevance to humans.
D000483:Alleles; D000818:Animals; D004586:Electrophoresis / Q000379:methods; D005796:Genes; D007527:Isoenzymes / Q000235:genetics; D051379:Mice / Q000235:genetics*; D009152:Mutagenicity Tests / Q000379:methods*; D009154:Mutation
D007527:Isoenzymes