[Suppression of myocardial lipid peroxidation during preventive treatment of transitory coronary insufficiency with myophedrine].
Experiments on 98 noninbred white male rats with experimental transitory coronary insufficiency (TCI) have confirmed the essential pathogenetic role of activation of myocardial free-radical lipid peroxidation (FRLP) in the mechanism of its development. Evidence has been also provided for FRLP suppression in the course of preventive use of myophedrine. It has been revealed that an increase in lipid oxidation correlates with suppression of heart contractility, that heart resistance to TCI increases during inhibition of lipid oxidation after preliminary administration of myophedrine. This evidence coupled with the literary data on the protective effect of the genuine antioxidant alpha-tocopherol in anoxia and heart reoxygenation in vitro document the efficacy of TCI during therapy and prevention with FRLP inhibitors.
D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008297:Male; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D010099:Oxyfedrine / Q000627:therapeutic use*; D011427:Propiophenones / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors
D008054:Lipid Peroxides; D011427:Propiophenones; D010099:Oxyfedrine
Podavlenie perekisnogo okisleniia lipidov miokarda pri tranzitornoĭ koronarnoĭ nedostatochnosti v usloviiakh profilakticheskogo primeneniia miofedrina.