Induction of female and male mating patterns in female rats by gonadal steroids: effects of neonatal or adult olfactory bulbectomy.
Hormonally mediated sexual response patterns were evaluated in female rats receiving olfactory bulb ablations neonatally (Day 2) or in adulthood. In a test of females' reactivity to a caged male in an open field, estrogen and progesterone treatments increased the number of squares entered and the number of cage contacts, but olfactory bulb removal had no effect on these measures. During mating tests, the feminine sexual behavior of females bulbectomized on Day 2 was similar to that of control-operated females, whereas females bulbectomized as adults displayed enhanced levels of lordosis, darting, and ear wiggling. Lordosis varied with estrogen dose, whereas darting was progesterone-dependent. In tests of masculine copulatory behavior, the proportion of bulbectomized females (Day 2 and adult) that mounted was significantly lower than that of control-operated females. The effects of olfactory bulb removal, which vary with the age at ablation and the behavioral system investigated, are not mediated by a single neuroendocrine system and cannot be interpreted in terms of a unitary "arousal' construct.
D000818:Animals; D000831:Animals, Newborn; D003307:Copulation / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009115:Muridae; D009830:Olfactory Bulb / Q000502:physiology*; D011374:Progesterone / Q000494:pharmacology*; D012726:Sexual Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D011374:Progesterone; D004958:Estradiol