M-Currents in voltage-clamped mammalian sympathetic neurones.
The M-current (IM), a species of time- and voltage-dependent K+-current previously identified in amphibian sympathetic neurones, has been detected in voltage-clamped rat sympathetic neurone somata. IM had an activation threshold of about -70 mV and, since it did not show time-dependent inactivation, contributed an increasing outward component to the steady membrane current between -70 and -20 mV. Selective inhibition of IM by muscarine or by angiotensin-II probably accounts for the membrane depolarization produced by these two agonists on rat ganglia.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D004553:Electric Conductivity; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials; D009116:Muscarine / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011188:Potassium / Q000494:pharmacology; D051381:Rats
D000804:Angiotensin II; D009116:Muscarine; D011188:Potassium