Protective effect of riboflavin on suppression of growth caused by oxidized oil.
When oxidized corn oil (100 nmol in terms of malondialdehyde/day/rat) was administered to a riboflavin-deficient rat, the body weight gain was markedly suppressed. However, when 20 microgram of riboflavin/day/rat was administered with the oxidized corn oil, reasonable growth and normal flavin levels in the liver, kidney and heart could be attained, though they were somewhat less than those of the animals fed on the normal diet containing non-oxidized corn oil. It was noted that the elevation of lipid peroxide level in blood plasma of animals administered with the oxidized oil was effectively prevented by riboflavin. These results indicate the protective effect of riboflavin on suppression of growth caused by the oxidized oil.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D006130:Growth Disorders / Q000139:chemically induced* / Q000188:drug therapy; D008297:Male; D008315:Malondialdehyde / Q000009:adverse effects; D009821:Oils / Q000009:adverse effects*; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D012256:Riboflavin / Q000627:therapeutic use*; D012257:Riboflavin Deficiency / Q000188:drug therapy; D003313:Zea mays
D009821:Oils; D008315:Malondialdehyde; D012256:Riboflavin