Increased levels of rat liver RNA polymerase I(A) and I(B) following the administration of triiodothyronine.
The levels of the transcribing RNA polymerase I(B) in the nucleus and of the non-transcribing RNA polymerase I(A) in the cytoplasm are both approximately doubled 24 h after a single i.p. injection of triiodothyronine into thyroidectomized rats. This suggests that the triiodothyronine-induced stimulation of ribosomal RNA synthesis is associated with an increase in the total RNA polymerase I content of rat liver cells.
D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology; D002852:Chromatography, Ion Exchange; D003593:Cytoplasm / Q000201:enzymology; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D012318:RNA Polymerase I / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013965:Thyroidectomy; D014284:Triiodothyronine / Q000494:pharmacology*
D014284:Triiodothyronine; D012321:DNA-Directed RNA Polymerases; D012318:RNA Polymerase I