Attenuation by a 5 alpha-reductase inhibitor of the activational effect of testosterone propionate on penile erections in castrated male rats.
Daily administration of an inhibitor of 5 alpha-reductase, 17 beta-testosterone carboxylic acid, significantly attenuated the stimulatory effect of testosterone propionate on penile erections displayed by castrated male rats which were restrained in a supine position. This treatment, however, failed to affect mating behavior in tests with sexually receptive females. The inhibitory effect of 17 beta-testosterone carboxylic acid on erection was reversed by concurrent administration of 5 alpha-dihydrotestosterone propionate, suggesting that the 5 alpha-reduced metabolite(s) of testosterone may normally contribute to the activation of penile erection in the rat.
D058891:5-alpha Reductase Inhibitors; D000818:Animals; D002369:Castration; D007700:Kinetics; D008297:Male; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D010413:Penis / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology*
D058891:5-alpha Reductase Inhibitors; D013739:Testosterone; C020509:testosterone 17 beta-carboxylic acid; D010088:Oxidoreductases