Hormonal therapy and alterations of immunity in prostatic cancer.
Retrospective evaluation of cell-mediated tumor-associated immunity in patients with prostatic cancer before and after the receipt of non hormonal or hormonal therapy disclosed that patients receiving hormonal therapy, i. e., orchiectomy and/or oestrogen, possessed significantly lower levels. The potential clinical relevancy of the suggested immunosuppressive effects of hormonal therapy on tumor-host responsiveness is considered in view of the present and previous observations.
D000230:Adenocarcinoma / Q000276:immunology* / Q000628:therapy; D002369:Castration; D002478:Cells, Cultured; D004967:Estrogens / Q000627:therapeutic use*; D006801:Humans; D007109:Immunity; D007957:Leukocyte Adherence Inhibition Test; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D011471:Prostatic Neoplasms / Q000276:immunology* / Q000628:therapy; D012189:Retrospective Studies
D004967:Estrogens