Intracranial complications of pediatric hematologic disorders: computed tomographic assessment.
Computed tomography (CT) findings in the intracranial complications of leukemia, hemophilia, and sickle cell anemia were reviewed in 19 children with these hematologic disorders. CT demonstrated intracranial hemorrhage, infarction, intracerebral mass, and post-therapeutic atrophy and leukoencephalopathy in leukemic children. Intracerebral, subarachnoid, subdural, and epidural hemorrhage was documented in patients with hemophilia. Bland and hemorrhagic infarctions were identified in children with sickle cell anemia. CT proved valuable in documenting the presence and extent of these abnormalities, titrating factor replacement in hemophiliac patients, and monitoring therapeutic toxicity in leukemic patients.
D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000000981:diagnostic imaging*; D001284:Atrophy / Q000209:etiology; D001921:Brain / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006467:Hemophilia A / Q000000981:diagnostic imaging*; D006801:Humans; D007938:Leukemia / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D008727:Methotrexate / Q000009:adverse effects; D011878:Radiotherapy / Q000009:adverse effects; D014057:Tomography, X-Ray Computed
D008727:Methotrexate