Amyloidosis in (CBA/J X A/J)F2 mice: correlation of amyloid resistance and low mitogenic response to concanavalin A.
A/J mice are highly resistant to induction of amyloidosis with serial injections of azocasein, compared to the CBA/J strain. (CBA X A) F2 hybrid mice were treated with azocasein, after spleen biopsy for assay of 3 immunologic functions differing in the parent strains. The proportions of amyloid susceptibility and resistance in the hybrid population conformed to the expectations for a single gene. Low responses to the T cell mitogen concanavalin A correlated with resistance to amyloid induction, whereas the response to lipopolysaccharide and the level of natural killer activity were independent of susceptibility to amyloidosis.
D000686:Amyloidosis / Q000209:etiology / Q000276:immunology*; D000818:Animals; D002364:Caseins / Q000031:analogs & derivatives* / Q000494:pharmacology; D003208:Concanavalin A / Q000494:pharmacology; D003433:Crosses, Genetic; D003602:Cytotoxicity, Immunologic; D006824:Hybridization, Genetic; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D008805:Mice, Inbred A / Q000235:genetics / Q000276:immunology*; D008808:Mice, Inbred CBA / Q000235:genetics / Q000276:immunology*
D002364:Caseins; D008070:Lipopolysaccharides; C026018:azocasein; D003208:Concanavalin A