Atypical myeloproliferative disorder associated with a 21 trisomic clone.
The hematological and cytogenetical studies of a case of atypical myeloproliferative disorder are reported. The patient displayed moderate leukocytosis, anemia and thrombocytopenia. Reduced or absent growth of CFU-C was observed in the bone marrow and peripheral blood. The cytogenetical analysis revealed a trisomy 21 limited to the neoplastic clone. The overall results are discussed and compared with the rare cases of acquired trisomy 21 reported in the literature.
D000368:Aged; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002904:Chromosomes, Human, 21-22 and Y; D006801:Humans; D007621:Karyotyping; D008297:Male; D009030:Mosaicism; D009196:Myeloproliferative Disorders / Q000235:genetics*; D014314:Trisomy