Inhibition of histidine decarboxylase by imidazole derivatives.
A series of 4-imidazolylmethyl arylsulfides, sulfoxides, and sulfones and two carbon isosteres of 4-imidazolylmethylphenyl sulfide (I) were synthesized and tested for inhibition of histidine decarboxylase from rat stomach. None of these analogs of I met the criterion of a potent and specific inhibitor of histidine decarboxylase.
D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D006640:Histidine Decarboxylase / Q000037:antagonists & inhibitors*; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D007093:Imidazoles; D002262:Carboxy-Lyases; D006640:Histidine Decarboxylase