Experience with cellulose acetate-coated activated charcoal haemoperfusion in the treatment of severe hypnotic drug intoxication.
A haemoperfusion column containing activated charcoal coated with cellulose acetate was used to treat 7 patients with barbiturate or ethchlorvynol poisoning. Six of the patients showed marked lightening of coma and all showed a significant fall in plasma drug concentration. Plasma drug clearance and platelet loss were similar to those reported for other coated charcoal columns. Cellulose acetate-coated charcoal haemoperfusion may reduce the period of coma in severe poisoning with barbiturates and other hypnotic drugs and thus the morbidity and mortality.
D000328:Adult; D001463:Barbiturates / Q000506:poisoning*; D002482:Cellulose / Q000031:analogs & derivatives; D002606:Charcoal; D004984:Ethchlorvynol / Q000506:poisoning*; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D008297:Male; D008875:Middle Aged
D001463:Barbiturates; D002606:Charcoal; C005062:acetylcellulose; D004984:Ethchlorvynol; D002482:Cellulose