[Ascorbic acid and cancer of the duodenum. An experimental study (author's transl)].
This study applies to the agency of vitamin C on chemical carcinogenesis in the small intestine of rats. Administration of N-Ethyl-N'-nitro-N-nitrosoguanidine (ENNG) in drinking water produced tumors of the small intestine after 18 weeks in more than 90%. The induction of tumors could not be suppressed by a large amount (2-3%) of sodium ascorbate in food, but the depth of tumor infiltration was restricted. Cancer developed in 29 of 36 rats receiving ENNG only. In 25 animals of this group growth of tumor corresponded to a P4 stage. In 24 of 35 animals, additionally receiving vitamin C, P4 stage was observed in only 13 cases. Pathological changes in the small intestine could not be observed after the sole administration of vitamin C.
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004379:Duodenal Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D004386:Duodenum / Q000473:pathology; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000031:analogs & derivatives / Q000494:pharmacology; D009374:Neoplasms, Experimental / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains
D008769:Methylnitronitrosoguanidine; C013525:ENNG; D001205:Ascorbic Acid
Vitamin C und Dünndarmkrebs. Eine experimentelle Studie.