[Increase in novobiocin activity and an expansion of its antimicrobial action spectrum].
It was found that with an increase in the medium acidity (pH 6.0 - 6.2) the antistaphylococcal effect of novobiocin significantly rose and the drug began to inhibit gram-negative bacteria, in particular, P. aeruginosa and Proteus. The method efficacy was demonstrated on a limited number of patients with urological infections caused by P. aeruginosa and increased acidity of the urine (because of cranberry juice use). Wider observations in patients with urological and some other diseases caused by gram-negative bacteria are advisable.
D001419:Bacteria / Q000187:drug effects*; D001437:Bacteriuria / Q000188:drug therapy; D003556:Cystitis / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D009675:Novobiocin / Q000494:pharmacology* / Q000627:therapeutic use; D011704:Pyelonephritis / Q000188:drug therapy
D009675:Novobiocin
Povyshenie aktivnosti novobiotsina i rasshirenie spektra ego antimikrobnogo deĭstviia.