[Morphological study of the adenyl cyclase activity of the rat heart in experimental hypoxia and ischemia].
Alteration of the activity and localization of the reaction of adenylcyclase after perfusion of the rat heart with nitrogen, carbon monoxide and after ischaemia was studied by electronmicroscopy. In the first minutes of hypoxia increase of the activity of the adenylcyclase was revealed. After perfusion with nitrogen during three hours and with carbon monoxide during 30 minutes intensity of the reaction was observed to be decreased. In ischaemia decrease of the intensity of the late reaction could not be observed. Alteration of the localization of the reaction in ischaemia and hypoxia was not significant. Administration of reserpine and propanol did not cause any alteration. Authors believe, that increase of the activity of the adenylcyclase may be caused by accumulation of an endogenous catecholamine.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D003327:Coronary Disease / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*; D051381:Rats
D000262:Adenylyl Cyclases
Az adenilcikláz aktivitásának morfológiai vizsgálata kísérletes hypoxiában és ischaemiában patkány szíven.