Radioruthenium -- 2,3-Dimercaptopropansulfonic acid complex. A potentially useful radiocompound for kidney studies.
Radioruthenium complexed with 2,3-dimercaptopropansulfonic acid (DMPSA) shows a preferential localization in kidneys. After studying several parameters with regard to their influence on renal incorporation, the optimal procedure was established, showing an uptake by kidney (for 97Ru-labelled compound) of 30.3% dose/g/24 h or 43.4% dose/organ/24 h. The highest accumulation was reached 7-10 h after iv injection and no significant elimination was observed 24 h thereafter. The probable mechanisms involved in this process are discussed.
D000818:Animals; D004112:Dimercaprol / Q000031:analogs & derivatives*; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000000981:diagnostic imaging* / Q000378:metabolism; D011817:Rabbits; D011868:Radioisotopes; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D012428:Ruthenium / Q000378:metabolism; D014018:Tissue Distribution; D014494:Unithiol
D011868:Radioisotopes; D004112:Dimercaprol; D014494:Unithiol; D012428:Ruthenium