Removal of interfering phenolic compounds in the analysis of drugs in biological material.
In toxicological analysis, problems often arise from interference of phenolic compounds (p-hydroxyphenyl-acetic acid, p-hydroxybenzoic acid, p-hydroxybenzaldehyde) in decomposing tissues. Drugs (such as paracetamol) may also interfere with the analysis of other drugs. This interference may be seen in ultraviolet spectrophotometric and/or gas chromatographic analysis. Removal of such phenols by a diazo reaction has been studied and a procedure evolved which eliminates the interference.
D002849:Chromatography, Gas / Q000379:methods; D006801:Humans; D004364:Pharmaceutical Preparations / Q000032:analysis*; D010636:Phenols / Q000302:isolation & purification*; D013425:Sulfanilic Acids
D004364:Pharmaceutical Preparations; D010636:Phenols; D013425:Sulfanilic Acids