Studies on the effects of 3-acetyl-4"-isovaleryltylosin against multiple-drug resistant strains of Staphylococcus aureus.
The macrolide-resistance of multiple-drug resistant strains of Staphylococcus aureus was divided into two types; the decreased sensitivity of ribosomes (type I) and the decreased uptake (type II). Both types were resistant to erythromycin, tylosin and 3-acetyltylosin, and their resistance was not inducible. 3-Acetyl-4"-isovaleryltylosin inhibited the growth of both types. Protein synthesis on ribosomes of type I in vitro (S. aures MS-9610) was inhibited by 3-acetyl-4"-isovaleryltylosin, but little or no inhibition was seen with either tylosin or 3-acetyltylosin. Ribosomes of type II in vitro (S. aureus MS-8710) were sensitive to all macrolides. 3-Acetyl-4"-isovaleryltylosin accumulated about twice as much as 3-acetyltylosin in intact cell of type II.
D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000096:biosynthesis; D004352:Drug Resistance, Microbial; D007933:Leucomycins / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D015645:Tylosin / Q000031:analogs & derivatives*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D007933:Leucomycins; C031783:3-acetyl-4''-isovaleryltylosin; D015645:Tylosin