[Amiodarone pigmentation. A rare, but typical drug side-effect].
Amiodarone is one of the most effective antiarrhythmic and anti-anginose drugs. A rare but typical side-effect with an incidence of 1:100 is sunburn, and of 1:1,000 a black-violet to slaty pigmentation of the sun-exposed skin areas. According to histochemical and ultrastructural findings the skin pigment deposits are considered to be lipofuscin.
D000328:Adult; D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D001572:Benzofurans / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D010787:Photosensitivity Disorders / Q000139:chemically induced; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000473:pathology; D012867:Skin / Q000473:pathology; D012880:Skin Pigmentation / Q000187:drug effects*; D013471:Sunburn / Q000139:chemically induced
D001572:Benzofurans; D000638:Amiodarone
Amiodaronepigmentierung. Eine seltene, aber typische Medikamentnebenwirkung.