[Clinical studies on flow properties of blood in the gynecological patients with potentially hypercoagulable state (author's transl)].
The flow property of blood, the blood viscosity was measured under such gynecological conditions that were potentially hypercoagulable: in the post-operative state for myoma uteri corporis, in the use of oral contraceptives and in the advanced stage of malignant uterine and ovarian tumors. The viscosity was measured at a shear rate of 0.989 sec-1 and at 37 degrees C. Blood viscosity after operation rose to 15.6 +/- 3.7 cp (mean +/- SD), which was significantly higher than that of pre-operative state (12.4 +/- 3.7 cp). This was due to increased hematocrit and fibrinogen levels. The viscosity returned to preoperative level on the 3rd day of post-operation. The blood viscosity of users of oral contraceptives was 15.1 +/- 2.7 cp, not being significantly higher than that of control women (13.4 +/- 2.8 cp). The blood viscosity of patients suffered from malignant tumors was 10.5 +/- 2.0 cp and was significantly lower than that of control. Comparison of viscosity at the same hematocrits revealed, however, that the viscosity of patients of malignant tumors was significantly higher than that of control. Such rheological characteristics in the patients of malignant tumors were due to decreased hematocrit and markedly increased fibrinogen levels. It was suggested that dehydration and infection should be avoided to prevent thrombus formation in the gynecological patients with potentially hypercoagulable state.
D000328:Adult; D001809:Blood Viscosity; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005831:Genital Diseases, Female / Q000097:blood*; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma / Q000097:blood; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood; D011184:Postoperative Period; D013923:Thromboembolism / Q000097:blood; D014594:Uterine Neoplasms / Q000097:blood
D005340:Fibrinogen