Induction of intestinal metaplasia in the glandular stomach of rats by X-irradiation prior to oral administration of N-methyl-N'-nitro-N-nitrosoguanidine.
CD/CRJ rats were subjected to localized X-irradiation of the stomach and given N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in the drinking water. Rats given MNNG alone and non-treated rats were used as controls. Upon sacrifice at 15 months after the initial MNNG administration, intestinal metaplasia was observed; the histology was of complete type and the incidence was 100% in rats treated with X-rays and MNNG, whereas in rats treated with MNNG alone the intestinal metaplasia was of incomplete type and its incidence was 80%. However, the incidence of gastric cancer in rats treated with MNNG alone was 25%.
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology*; D000284:Administration, Oral; D000818:Animals; D008679:Metaplasia; D008769:Methylnitronitrosoguanidine; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D051381:Rats; D013270:Stomach / Q000473:pathology*; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000473:pathology*; D013936:Thymidine / Q000378:metabolism
D008769:Methylnitronitrosoguanidine; D013936:Thymidine