Microspheres in cardiac lymph: control and ischemic states.
The cardiac lymph from conscious animals was monitored for the presence or absence of radiolabelled 15 micrometer microspheres during: 1) control periods after left atrial injection of microspheres and b) after circumflex coronary artery (CFX) occlusions (10--20 min total or less than 40 mins 50% of control flow) followed by full reperfusions. Microspheres (15 mu) numbering 7--150 were present in the lymph within 2 hrs after the occlusions; and in three experiments, the presence of a small number in the lymph on the following day implied continual release overnight. No microspheres were present in 8--48 hr lymph samples prior to occlusions. This study suggests that some microspheres escape from the intravascular space of the myocardium and are channeled into the cardiac lymphatics; this is apparent even after short-term ischemic events.
D000818:Animals; D002408:Catheters, Indwelling; D002565:Cerium Radioisotopes / Q000008:administration & dosage; D003327:Coronary Disease / Q000503:physiopathology*; D004285:Dogs; D006321:Heart / Q000033:anatomy & histology*; D008196:Lymph / Q000502:physiology*; D008208:Lymphatic System / Q000503:physiopathology; D008863:Microspheres; D011868:Radioisotopes / Q000008:administration & dosage; D012428:Ruthenium / Q000008:administration & dosage; D013326:Strontium Radioisotopes / Q000008:administration & dosage
D002565:Cerium Radioisotopes; D011868:Radioisotopes; D013326:Strontium Radioisotopes; D012428:Ruthenium