Chemical modification of fortimicins. III. preparation of N-substituted fortimicin A derivatives.
The 1, 2' or 6'-amino group of fortimicin A was alkylated or acylated and the antimicrobial activities of the derivatives were compared with each other. 2'-N-Substituted fortimicins A were active against the fortimicin A resistant strain which produced AAC(3)-I. AAC(3)-I is the only enzyme which can inactivate fortimicin A. Among the derivatives prepared in the present study, 2'-N-[(S)-4-amino-2-hydroxybutyl]fortimicin A showed stronger activity than fortimicin A.
D000617:Aminoglycosides / Q000138:chemical synthesis / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D008968:Molecular Conformation
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C023384:fortimicin A