[Effect of temperature on the kinetics of propranolol, theophylline, phenytoin and digoxin in rats (author's transl)].
1. The effect of chronic hyperthermia (35 degree C for 1 month) on the kinetics of propranolol, theophylline, diphenylhydantoin and digoxin was studied in groups of male Wistar rats. 2. Each compound was administered by intravenous injection, dosage being 2 mg/kg for propranolol, 3 mg/kg for theophylline, 10 mg/kg for phenytoin, and 0.01 mg/Kg for digoxin. 3. Total body clearance was diminished, mainly by an increase in the elimination half-life, for propranolol, theophylline, and digoxin. That of phenytoin remained unchanged. 4. Distribution volume increased slightly with propranolol, theophylline, digoxin.
D000818:Animals; D004077:Digoxin / Q000378:metabolism*; D006207:Half-Life; D007700:Kinetics; D008297:Male; D010672:Phenytoin / Q000378:metabolism*; D011433:Propranolol / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013696:Temperature; D013806:Theophylline / Q000378:metabolism*
D010672:Phenytoin; D004077:Digoxin; D011433:Propranolol; D013806:Theophylline
Influence de la température sur la cinétique du propranolol, de la theophylline, de la phenytoine et de la digoxine chex le rat.