Production of chronic heart block in closed-chest dogs: an improved technique.
Chronic complete heart block was produced in 38 closed-chest anesthetized dogs with a special cannula introduced via a jugular vein. A Formalin mixture (0.2-1.0 ml, consisting of equal amounts of 40% Formalin and radiopaque material) was injected through this cannula into the His bundle, which was located with a His-bundle catheter. The entire procedure took approximately 30 min and was successful in 90% of the cases.
D000818:Animals; D002036:Bundle of His / Q000187:drug effects; D006328:Cardiac Catheterization / Q000379:methods; D004285:Dogs; D005557:Formaldehyde; D006327:Heart Block / Q000139:chemically induced*; D008297:Male
D005557:Formaldehyde