[Anti-ulcer effect of gamma-aminobutyric acid and its mechanisms of action].
It has been shown in experiments on white rats with chronic gastric ulcer induced according to the method of Takashi and coworkers that intramuscular administration of gamma-aminobutyric acid (GABA) exerts a pronounced antiulcerous effect. As compared with ganglerone, GABA reduces the content of free physiologically active histamine in the gastric mucosa to a far greater extent. The relationship has been disclosed between the therapeutic effect of GABA and the decreased content of histamine in the gastric mucosa.
D000818:Animals; D000897:Anti-Ulcer Agents; D001565:Benzoates / Q000627:therapeutic use; D002908:Chronic Disease; D005753:Gastric Mucosa / Q000032:analysis; D006632:Histamine / Q000032:analysis; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use*
D000897:Anti-Ulcer Agents; D001565:Benzoates; D005680:gamma-Aminobutyric Acid; D006632:Histamine; C007824:ganglerone
Protivoiazvennyĭ éffekt gamma-aminomaslianoĭ kisloty i mekhanizmy ee deĭstviia.