Transformation of Syrian hamster embryo cells by sodium bisulfite.
Exposure at neutral pH of Syrian hamster embryo cells (HEC) to non-lethal, non-mutagenic doses of bisulfite, the physiological form of SO2, causes a dose-dependent increase in transformation. When bisulfite is used in combination with UV irradiation, the induction of transformation is not synergistic. These results suggest that bisulfite transformation of HEC may not occur by a mechanism involving mutation.
D000818:Animals; D001483:Base Sequence / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival; D002478:Cells, Cultured / Q000187:drug effects* / Q000528:radiation effects; D006224:Cricetinae; D004247:DNA; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian; D006863:Hydrogen-Ion Concentration; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D013447:Sulfites / Q000494:pharmacology*; D014466:Ultraviolet Rays
D009153:Mutagens; D013447:Sulfites; D004247:DNA; C009279:sodium bisulfite