Transplacental carcinogenic effect of n-nitrosoethylurea in dogs.
During the late period of pregnancy (on the 50th and 53rd days post coitum) 2 dogs were injected intraperitoneally with 100 mg/kg (a single administration) of nitrosoethylurea. Nine puppies were born. During the 9 year period of observation no tumours were detected in mother-dogs. Three of 9 offspring developed the following tumours: brain haemangioblastoma (on the 526th day after administration), nephroblastoma and spleen angioleiomyoma (on the 845th day after administration) and adenoma of thyroid gland (after 7 years). Among other lesions 3 offspring-dogs developed polycystic kidneys. The revealed tumours of brain, kidney and spleen could be connected with transplacental carcinogenic effect of N-nitrosoethylurea (NEU), while neoplasms of these localizations and types rarely occur in dogs spontaneously.
D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced; D004285:Dogs; D005038:Ethylnitrosourea / Q000633:toxicity*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D007680:Kidney Neoplasms / Q000139:chemically induced; D008297:Male; D009369:Neoplasms / Q000139:chemically induced* / Q000473:pathology; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009607:Nitrosourea Compounds / Q000633:toxicity*; D011247:Pregnancy; D013160:Splenic Neoplasms / Q000139:chemically induced; D013964:Thyroid Neoplasms / Q000139:chemically induced
D009607:Nitrosourea Compounds; D005038:Ethylnitrosourea