[3H]Dopamine accumulation and release from striatal slices in young, mature and senescent rats.
Examinations of [3H]dopamine ([3H]DA) release following KCl or amphetamine administration in striatal slices from young (7 month), and senescent (24 month) Wistar rats showed no age-related changes. Further, the amount of [3H]DA accumulated in the striatal slices showed no changes with age. Thus, previously reported age-related deficits in motor behavior (i.e. rotational) are not produced by changes in striatal DA accumulation or release.
D000375:Aging; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D011189:Potassium Chloride; D000661:Amphetamine; D004298:Dopamine