Myelination-dependent axonal membrane specializations demonstrated in insufficiently myelinated nerves of the dystrophic mouse.
"Dystrophic' mice of the 129/ReJ-Dy strain have a genetic defect affecting Schwann cell proliferation. Spinal nerve roots of these animals contain myelinated and unmyelinated axons in addition to groups of large "amyelinated' axons. In affected regions of the spinal roots, myelinated axons are missing their myelin sheaths. Where the myelination terminates or begins, half-nodes are created. Freeze-fracture analysis of these half-nodes shows that only the myelinated side contains rows of dimeric particles in the axonal P-face of the paranode. The P-face on the amyelinated side of a half-node, and the remainder of the amyelinated axon. contains a dense even distribution of particles, many of which are the size of dimeric-particle subunits, but only a few of which are arranged into short rows. As the long circumferential rows are not found on the unmyelinated side of the myelinated side of the half-node we conclude that the paranodal rows of dimeric particles are dependent upon myelination for their organization.
D000818:Animals; D001369:Axons / Q000648:ultrastructure*; D051379:Mice; D008815:Mice, Inbred Strains; D009137:Muscular Dystrophy, Animal / Q000473:pathology*; D009186:Myelin Sheath / Q000648:ultrastructure; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure*; D009441:Neurilemma / Q000648:ultrastructure*; D009457:Neuroglia / Q000648:ultrastructure; D011901:Ranvier's Nodes / Q000648:ultrastructure; D012583:Schwann Cells / Q000648:ultrastructure