[Effect of psychodrugs on morphine effectivity (author's transl)].
After withdrawal of daily treatment with haloperidole (2 mg/kg s.c.) and apomorphine (10 mg/kg s.c.) for 21 days, respectively, and clomipramine (15 mg/kg s.c.) for 28 days, a decrease of morphine analgesia is observed. The findings are interpreted as a sensitivity change of the transmission systems involved in the action mechanism of the antinocifensive morphine effect. Morphine lethality remains unaffected by the synaptic efficiency of the transmission systems investigated.
D000698:Analgesia; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D002997:Clomipramine / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009020:Morphine / Q000037:antagonists & inhibitors*; D013997:Time Factors
D009020:Morphine; D006220:Haloperidol; D001058:Apomorphine; D002997:Clomipramine
Einfluss von Psychopharmaka auf die Morphineffektivität.