Endodermal sinus tumor of the ovary with virilization. Light- and electron-microscopic study.
A case of endodermal sinus tumor of the ovary associated with hirsutism and increased testosterone production is described. Electron-microscopic examination revealed accumulation of basement membrane-like material and other ultrastructural features consistent with endodermal sinus tumor. Groups of polyhedral cells associated with the tumor were found to contain abundant lipid material. These luteinized stromal cells were evidently responsible for the endocrine manifestations.
D000328:Adult; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008649:Mesonephroma / Q000473:pathology* / Q000648:ultrastructure; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D009384:Paraneoplastic Endocrine Syndromes / Q000473:pathology*; D014770:Virilism / Q000209:etiology*