[Inhibitory effect of remantadine hydrochloride on oncornavirus production and transformation of a continuous culture of mouse leukemia cells].
20-methylcholantrene in a concentration of 5 micrograms/ml and exposure for 72 hours as well as in a concentration of 2.5 micrograms/ml and exposure for 72 and 240 hours caused transformation of a continuous mouse leukemia cell culture producing Rauscher leukemia virus. Remantadine hydrochloride in non-toxic concentrations (12.5 and 6.25 micrograms/ml) decreased infectious virus production by cells of this culture and prevented its transformation by 20-methylcholantrene for 6 months.
D000218:Adamantane / Q000031:analogs & derivatives*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced*; D007942:Leukemia, Experimental; D008748:Methylcholanthrene / Q000037:antagonists & inhibitors*; D051379:Mice; D008807:Mice, Inbred BALB C; D011925:Rauscher Virus / Q000254:growth & development*; D012299:Rimantadine / Q000494:pharmacology*
D000998:Antiviral Agents; D012299:Rimantadine; D008748:Methylcholanthrene; D000218:Adamantane
Ingibiruiushchee deĭstvie solianokislogo remantadina na produktsiiu onkornavirusa i transformatsiiu perevivaemoĭ kul'tury leĭkoznykh kletok myshi.