[Effect of tetragastrin on electrical and contractile activities of the canine stomach and duodenum (author's transl)].
The effect of tetragastrin on stomach and duodenum in conscious dogs was studied by using bipolar electrodes and strain gauges. (1) The basal electric rhythm interval of stomach and duodenum became short under the administration of gastrin and it's changes were the same in cases of fasting or feeding as well as medical vagotomy. Also the response was found to be dependent on it's dosage. (2) Gastrin had no constant effect on the propagation velocity of stomach. (3) The basal electric rhythm interval at maximum point of the shortening after the intramuscular injection of 4 micrograms/kg of gastrin, was roughly equal with the interval of animals having the continuous intravenous infusion 5 micrograms/kg/h of gastrin. The shortening of the basal electric rhythm interval was recognized for 60--90 minutes. (4) Gastrin changed the pattern of contractile activities of the stomach from that of a fasted condition to a regular contraction which is usually recognized after meals. The strength of regular contraction of the stomach was dependent on the dosage of gastrin. (5) The maximum driven frequencies were slightly reduced during gastrin stimulation, compared to normal stomach frequencies.
D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000502:physiology*; D004435:Eating; D004576:Electromyography; D005755:Gastrins / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D013270:Stomach / Q000502:physiology*; D013758:Tetragastrin / Q000494:pharmacology*
D005755:Gastrins; D013758:Tetragastrin