Induction by phenobarbital of ornithine decarboxylase activity in rat liver after initiation with diethylnitrosamine.
Dietary administration of 0.1% phenobarbital (PB) for 1-2 weeks increased ornithine decarboxylase (ODC) activity slightly but to a significant extent (P less than 0.05) in livers of rats into which diethylnitrosamine (DEN) (200 mg/kg body wt) had been injected intraperitoneally 2 weeks before phenobarbital feeding. The increase was observed only under the controlled feeding schedule which avoided the effect of food intake.
D000818:Animals; D002262:Carboxy-Lyases / Q000096:biosynthesis*; D004052:Diethylnitrosamine / Q000494:pharmacology*; D004790:Enzyme Induction; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D009602:Nitrosamines / Q000494:pharmacology*; D009955:Ornithine Decarboxylase / Q000096:biosynthesis*; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009602:Nitrosamines; D004052:Diethylnitrosamine; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase; D010634:Phenobarbital