Combined pharmacologic and surgical treatments for acute spinal cord trauma.
Acute spinal cord trauma was induced by the Allen method at T12 in 48 dogs. Six groups of 7 dogs each were treated with combinations of pharmacologic and surgical treatments; a 7th group of 6 dogs remained as traumatized nontreated controls. Results indicate an additive therapeutic effect in those patients treated with myelotomy and dimethyl sulfoxide. Dexamethasone, reserpine, and perfusion with hypertonic dextrose solution were of no benefit.
D000208:Acute Disease; D000818:Animals; D003907:Dexamethasone / Q000627:therapeutic use; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D004285:Dogs; D005260:Female; D005947:Glucose; D008297:Male; D010477:Perfusion / Q000662:veterinary; D012110:Reserpine / Q000627:therapeutic use; D013116:Spinal Cord / Q000601:surgery; D013119:Spinal Cord Injuries / Q000628:therapy / Q000662:veterinary*
D003907:Dexamethasone; D012110:Reserpine; D005947:Glucose; D004121:Dimethyl Sulfoxide