Bilateral incipient germ cell tumours of the testis in the incomplete testicular feminization syndrome.
The presence of bilateral incipient germ cell tumours in the testes of two cases of the incomplete testicular feminization syndrome (TFS) is reported and found to resemble that occurring in the testes of infertile men. Both the nature and nomenclature of the lesion is discussed, as is its relevance in the early diagnosis and improved therapy of testicular tumours, which occur frequently in TFS. Suggestions are made for a more complete postpubertal surveillance in these patients, including assay of tumour markers and bilateral biopsies in cases of complete TFS. In this condition the removal of the testes is usually delayed until the twenties when total feminization is achieved, thus increasing the chances of tumour development.
D000293:Adolescent; D002369:Castration; D002648:Child; D004407:Dysgerminoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D005260:Female; D005262:Feminization / Q000150:complications / Q000473:pathology*; D006801:Humans; D008297:Male; D013577:Syndrome; D013736:Testicular Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery