[Trypsin deficiency in diabetes mellitus of children and adolescents (author's transl)].
In 111 children and juveniles aged 7--27 years suffering from insulin-dependent diabetes mellitus the immunoreactive plasma human pancreatic trypsin was measured by means of the method RIAGnost-Trypsin-test, Behring. Decreased plasma trypsin was measured at the onset of diabetes already. In patients with diabetes with a period of 8--13 years the trypsin values were found to be significantly lower (79.6 +/- 35.3 ng/ml) than in these suffering from diabetes 0--3 years (100,4 +/- 36.9 ng/ml). None of all these patients had clinical pancreatic disease. Abnormalities in exocrine pancreatic function occur in patients with insulin-dependent diabetes mellitus, which is not confined to pancreatic islets only. Until today clinical consequences not can be drawn.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D014357:Trypsin / Q000172:deficiency*
D014357:Trypsin
Trypsinmangel bei Diabetes mellitus im Kindes- und Jugendlichen Alter.