The treatment of erythroblastosis with promethazine hydrochloride.
Seventy-two patients with Rh erythroblastosis were treated with promethazine hydrochloride (P-HCl) during a seven-year period. Compared to the pregnancy outcome of the immediately preceding pregnancies, we have found a significant decrease in perinatal mortality and exchange transfusions. No significant toxicity from P-HCl treatment has been noted, and none of these patients developed preeclampsia.
D000653:Amniotic Fluid / Q000187:drug effects; D004899:Erythroblastosis, Fetal / Q000188:drug therapy* / Q000517:prevention & control; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D005313:Fetal Death / Q000209:etiology; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D011247:Pregnancy; D011398:Promethazine / Q000627:therapeutic use*
D011398:Promethazine