Preparation of drugs used in hyperacidity. Part III. Stability of alumina gels.
The effect of temperature on the stability of alumina gels heated in the solid state and in the suspension was investigated. The suspensions were made in water, 1,4-dioxane and their mixture. It was found that the ageing of gels occurs during heating them in the solid state, in water and water-dioxane mixture as a first order reaction. The neutralizing properties of gel heated in 100% dioxane were not changed. The phase analysis of the investigated preparations was based on X-ray measurements. The contribution of water in the mechanism of gel changes is discussed.
D000536:Aluminum Hydroxide / Q000032:analysis*; D004355:Drug Stability; D004356:Drug Storage; D006358:Hot Temperature; D014867:Water / Q000494:pharmacology
D014867:Water; D000536:Aluminum Hydroxide