[On the question of parenchyma damage caused by long-term therapy with psychotropics in adolescence].
For 341 patients treated with psychotropics over different periods of time and with different dosages laboratory examinations were carried out in order to discover as far as possible toxic damage of the parenchyma of liver, kidneys, and blood-formation systems. Statistically secured differences of some liver functions and of the serum creatinine between treated and untreated patients were seen for which, however, no sufficient indication of direct toxic damage was found. The deviations were interpreted as allergic and caused by enzyme induction.
D000293:Adolescent; D000328:Adult; D056486:Chemical and Drug Induced Liver Injury; D002648:Child; D002746:Chlorpromazine / Q000009:adverse effects; D003404:Creatinine / Q000097:blood; D005500:Follow-Up Studies; D006410:Hematopoiesis; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology; D008107:Liver Diseases / Q000097:blood / Q000503:physiopathology; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
D011619:Psychotropic Drugs; D003404:Creatinine; D002746:Chlorpromazine
Zur Frage der Parenchymschäden durch langfristige Therapie mit Psychopharmaka im Jugendalter.