Effect of aligeron on the resistance of the cerebral and peripheral blood vessels.
The effect of the cinnarizine analogue Aligeron on the resistance of cerebral and peripheral blood vessels was studied in acute experiments on cats and dogs. The resistance of the cerebral vessels was determined directly and indirectly. For direct determination the method of autoperfusion was used. The resistance was calculated indirectly as a quotient of mean arterial blood pressure and internal carotid blood flow. For evaluation of Aligeron effect on the resistance of the peripheral blood vessels and method of autoperfusion of the femoral artery was used. Aligeron was administered i. v. and i. a. In some of the experiments the compound was applied on the background of previously injected dihydroergotamine. Cinnarizine and papaverine were used as reference compounds. The results show that Aligeron decreases considerably the cerebral and peripheral resistance vessels tone, and its effect is higher than those of cinnarizine. For the realization of this effect most probably its direct myotropic action plays the main role. The reduction of its effect after alpha-adrenergic blockade suggests an involvement of some adrenergic blocking properties in its mechanism of vascular action.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002343:Carotid Artery, Internal / Q000187:drug effects* / Q000502:physiology; D002415:Cats; D002936:Cinnarizine / Q000031:analogs & derivatives / Q000494:pharmacology*; D004285:Dogs; D005263:Femoral Artery / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D010879:Piperazines / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
D010879:Piperazines; D014665:Vasodilator Agents; D002936:Cinnarizine; C021591:Aligeron