[Effect of antihypertensives on the activity of lipoprotein lipase of cardiac tissue in rabbits, and normotonic and spontaneously hypertensive rats].
The influence of reserpine, alpha-methyldopa and clonidine on the activity of lipoprotein lipase (LPL) of the rabbit heart and the effect of reserpine on the LPL activity of the cardiac tissue of normotonic and spontaneously hypertensive rats was investigated by a modified method of Robinson, Reserpine and alpha-methyldopa caused in the rabbit heart muscle a pronounced increase in LPL activity by 74 and 35%, respectively. Stimulation by clonidine was not statistically verified. Application of reserpine increases the LPL activity in the hearts both of normotonic and spontaneously hypertensive rats. The enzyme activity in the hypertrophied hearts of spontaneously hypertensive rats is not enhanced. The results are discussed in connection with changes of the catecholamine level.
D000818:Animals; D002395:Catecholamines / Q000032:analysis; D003000:Clonidine / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology*; D006973:Hypertension / Q000201:enzymology; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D011817:Rabbits; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*
D002395:Catecholamines; D012110:Reserpine; D008071:Lipoprotein Lipase; D003000:Clonidine; D004298:Dopamine
Einfluss von Antihypertensiva auf die Aktivität der Lipoproteinlipase des Herzgewebes von Kaninchen sowie normotonen und spontanhypertone Ratten.