Light-stimulated release of taurine from retinas of kainic acid-treated chicks.
The light-stimulated release of [3H]taurine from chick retina was studied in chicks intraocularly injected with kainic acid (60 nmol). This treatment produced a loss of more than 80% of the inner nuclear and the inner synaptic layers, sparing the outer retinal layers. Concomitantly, the treatment produced a marked decrease of endogenous GABA and glycine but not of taurine. The activity of glutamate decarboxylase was also markedly decreased in the kainic acid-treated retinas. The release of [3H]taurine, either spontaneous or stimulated by light, was unaffected by the treatment. These results suggest that the light-stimulated efflux of taurine occurs from the retinal layers which are not affected by the kainic acid treatment.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002645:Chickens; D005968:Glutamate Decarboxylase / Q000378:metabolism; D007608:Kainic Acid / Q000494:pharmacology*; D008027:Light; D010786:Photoreceptor Cells / Q000187:drug effects / Q000378:metabolism; D011759:Pyrrolidines / Q000494:pharmacology*; D012160:Retina / Q000187:drug effects / Q000378:metabolism*; D013654:Taurine / Q000378:metabolism*
D000596:Amino Acids; D011759:Pyrrolidines; D013654:Taurine; D005968:Glutamate Decarboxylase; D007608:Kainic Acid