Studies on the effects of L-ascorbic acid on acetaminophen-induced hepatotoxicity. 1. Inhibition of the covalent binding of acetaminophen metabolites to hepatic microsomes in vitro.
D000082:Acetaminophen / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D006224:Cricetinae; D005260:Female; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008647:Mesocricetus; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000494:pharmacology
D013438:Sulfhydryl Compounds; D000082:Acetaminophen; D001205:Ascorbic Acid