Striatal dopamine turnover and L-dopa treatment after short-term exposure of rats to manganese.
The turnover rate of striatal dopamine (DA) and the effect of L-dopa treatment was investigated in rats after the daily oral administration of MnCl2 . 4H20 for a period of 30 days. The turnover rate of striatal DA, as determined by the administration of alpha-methyl-p-tyrosine, increased significantly in manganese-exposed rats. L-Dopa administration resulted in a significant elevation in the levels of DA and its metabolite, homovanillic acid, in manganese-exposed rats, but these neurochemical changes could not be correlated with the concentration of manganese in the striatum. We therefore advise the L-dopa therapy should not be tried in early manganese intoxication, as it may aggravate manic symptoms due to marked increase in brain DA.
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism; D007980:Levodopa / Q000627:therapeutic use*; D008345:Manganese / Q000378:metabolism; D020149:Manganese Poisoning; D051381:Rats
D008345:Manganese; D007980:Levodopa; D004298:Dopamine; D006719:Homovanillic Acid