[The effect of prostaglandins E1 and F1 alpha and indomethacin on haemodynamic and renal endocrine and exocrine function (author's transl)].
1. The PGE1, infused into the renal artery of the dog, increased RPF, Sodium and Potassium excretion rate and UV; it diminished the EPAH and FF but did not alter GFR and PRA. 2. The indomethacin, injected IV, in an other group of animals, decreased RPF, GFR, Sodium and Potassium excretion rate and PRA, and it increased the EPAH and FF. The administration of the PGE1, inversed the results obtained by indomethacin except those of PRA. 3. The infusion of the PGF1a, in other groups of dogs, did not alter either before or after the administration of indomethacin the parameters measured. 4. It was suggested that 1) neither the PGE1 nor the PGF1a stimulated renin synthesis, in the conditions that our experiments took place. The decrease of renin synthesis by indomethacin must be provoked by the inhibition of an other substance than the PGE and PGF and 2) the role of PGE in renal haemodynamic and exocrine renal function seems to be important.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004702:Endocrine Glands / Q000187:drug effects; D005088:Exocrine Glands / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects*; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*
D011458:Prostaglandins E; D011460:Prostaglandins F; D007213:Indomethacin
L'effect des prostaglandines E1 et F1 alpha et de l'indométacine sur l'hémodynamique et les fonctions endocrine et exocrine rénales.