Effects of hydrocortisone sodium succinate on the electrophysiological properties of hypoxic rabbit papillary muscle.
Hydrocortisone sodium succinate (HSS) (50 mg/1) was tested as a protective agent against the effects of hypoxia on rabbit papillary muscle fibres. No effect of HSS was observed on the electrophysiological variables studied in aerobic condition. Hypoxia (65-75 mmHg, 8.66-10.0 kPa) had no effects on the resting potential, amplitude and overshoot, and shortened the action potential at 0 and -60 mV levels of repolarization. In the presence of HSS the resting potential, amplitude and overshoot were also unaffected by the hypoxic condition. However, when measured at -60 mV level the changes on the repolarization phase after 15 and 60 minutes of hypoxia were significantly reduced, 14% and 24% respectively (p less than 0.001) as compared with the values obtained in the series without HSS.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004594:Electrophysiology; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000494:pharmacology; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D010101:Oxygen Consumption; D010210:Papillary Muscles / Q000503:physiopathology*; D011817:Rabbits
C007133:hydrocortisone hemisuccinate; D006854:Hydrocortisone