A system for pharmacological studies in small animals at high pressure.
A four-liter pressure chamber was constructed for pharmacological experiments in rats; it consisted of the following: 1) a system for repeated, accurate injection; 2) an alternative single-dose injection system; 3) a system for direct blood sampling to the outside. The injection and sampling systems were tested for possible drug adsorption at 71 ATA. The accuracy of drug concentration measurements in samples collected through the sampling system at pressure was found to be satisfactory.
D000818:Animals; D001273:Atmosphere Exposure Chambers / Q000295:instrumentation*; D001274:Atmospheric Pressure; D003975:Diazepam / Q000378:metabolism; D008297:Male; D004364:Pharmaceutical Preparations / Q000378:metabolism; D051381:Rats
D004364:Pharmaceutical Preparations; D003975:Diazepam