Properties and clinical significance of an alkaline phosphatase-lipoprotein-X complex.
The existence of an alkaline phosphatase-lipoprotein-X complex was demonstrated as an abnormally moving band in the agar-agarose gel alkaline phosphatase pattern of sera from 58 patients in a group of 72 patients whose sera contained lipoprotein-X. The position of the abnormally moving band in the agar-agarose gel alkaline phosphatase pattern and the percentage of alkaline phosphatase activity in the complex in relation to the total serum alkaline phosphatase activity depend on the serum lipoprotein-X concentration. The presence of the complex is a reliable indicator for cholestasis and of limited value in the differentiation between intrahepatic and extrahepatic cholestasis.
D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood*; D001651:Cholestasis, Extrahepatic / Q000175:diagnosis / Q000201:enzymology; D002780:Cholestasis, Intrahepatic / Q000175:diagnosis / Q000201:enzymology; D002850:Chromatography, Gel; D004587:Electrophoresis, Agar Gel; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008073:Lipoprotein-X / Q000097:blood*; D008297:Male; D008875:Middle Aged
D007527:Isoenzymes; D008073:Lipoprotein-X; D000469:Alkaline Phosphatase