Release of radiolabeled dopamine, p-tyramine, and m-tyramine from rat striatal slices by some aminotetralins.
The effect of several 2-aminotetralins (2ATs) on the uptake and release of [14C] dopamine and [2H]m- or [3H]p-tyramine by rat striatal slices was examined. 6,7-Dihydroxy-2AT (6,7OHAT) and 5,6-dihydroxy-2-methyl-AT (5,6OHMeAT) were the most potent uptake inhibitors as well as the most potent releasers of the three labeled amines. The 5-, 6-, and 7-hydroxy-2-N, N-dipropyl-ATs (5-, 6-, and 7OHdiPrAT) and 5,6-dihydroxy-2-N,N-dipropyl-AT (5,6OHdiPrAT) significantly inhibited the uptakes of the three labeled amines, but they released only the tyramines. The dipropyl substitutions of a 2AT appeared to confer a tyraminergic specificity to its release properties. To verify this supposition, 2AT was compared to 2-N,N-dipropyl-AT (diPrAT). Although 2AT released both [3H]p-tyramine and [14C]dopamine, diPrAT released only [3H]p-tyramine. None of the compounds, however, differentiated between m- and p-tyramine. It was concluded that the release of tyramines could be implicated in the actions of some of the 2ATs and that the tyramines can be transported independently from dopamine.
D015081:2-Naphthylamine / Q000031:analogs & derivatives / Q000494:pharmacology*; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000031:analogs & derivatives*; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D066298:In Vitro Techniques; D007536:Isomerism; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology*; D051381:Rats; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*; D014439:Tyramine / Q000378:metabolism*
D009281:Naphthalenes; D013764:Tetrahydronaphthalenes; C006561:2-aminotetralin; C017233:5,6-dihydroxy-2-methylaminotetralin; C011639:ADTN; C015842:2-(N,N-dipropyl)amino-5,6-dihydroxytetralin; C011799:5-hydroxy-2-N,N-dipropylaminotetralin; C031348:6-hydroxy-2-N,N-dipropylaminotetralin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D015081:2-Naphthylamine; C028169:3-tyramine; C031349:7-hydroxy-2-N,N-dipropylaminotetralin; D004298:Dopamine; D014439:Tyramine