DNA-damaging agents and DNA-synthesis inhibitors induce luminescence in dark variants of luminous bacteria.
The DNA-damaging agents mitomycin C and UV irradiation, as well as the DNA-synthesis inhibitors nalidixic acid, novobiocin and coumermycin, induce the de novo synthesis of luciferase and in vivo luminescence in dark variant cells of the luminous bacteria Photobacterium leiognathi. Mitomycin C and nalidixic acid also cause the induction of luminescence in wild-type cells in the absence of its natural inducer. In spite of the high level of in vivo luminescence of the treated dark-variant cells, none of these agents result in the appearance of genetically luminous revertants. The possibility is discussed that these agents phenotypically induce luminescence through their ability to trigger 'SOS functions', which in turn leads to the transitory inactivation of certain repressors.
D049933:Aminocoumarins; D003374:Coumarins / Q000494:pharmacology; D004789:Enzyme Activation; D008156:Luciferases / Q000096:biosynthesis*; D008937:Mitomycins / Q000494:pharmacology; D009154:Mutation / Q000187:drug effects* / Q000528:radiation effects; D009268:Nalidixic Acid / Q000494:pharmacology; D009675:Novobiocin / Q000494:pharmacology; D010776:Photobacterium / Q000235:genetics* / Q000528:radiation effects; D011758:Pyrroles / Q000494:pharmacology; D014466:Ultraviolet Rays
D049933:Aminocoumarins; D003374:Coumarins; D008937:Mitomycins; D011758:Pyrroles; D009675:Novobiocin; D009268:Nalidixic Acid; D008156:Luciferases; C004628:coumermycin