[Control of implantation in rats and sows by peroral administration of prostaglandin synthetase inhibitors. 2. Effects of prostaglandin F2 alpha, progesterone/estrone, and acetylsalicylic acid on implantation and various biochemical parameters of amniotic fluid in the rat].
The highest pregnancy rate as well as most of all implantates and lowest foetal loss were recorded from the prostaglandin F2 alpha-(PGF2 alpha)-group (84, 84, and 16 per cent), while values following progesterone/oestrone and acetylsalicylic acid treatment were below those obtained from the controls. The highest number of normally developed (97 per cent) and the lowest number of degenerated foetuses (three per cent) were recorded following acetylsalicylic acid treatment, as compared to the control group (91 and nine per cent). Application of prostaglandin had no adverse effect on foetal development. The overall protein concentration in the amniotic fluid, following injection of progesterone/oestrone and PGF2 alpha, was lower with significance than the control value. Acetylsalicylic acid caused slight but insignificant rise in protein concentrations. The behavior of glucose concentrations in the amniotic fluid seemed to be diametrically opposed to that of protein. The activity of acid phosphatase was low and highly variable in all four experimental groups. Values moderately increased over the controls were recorded from the acetylsalicylic acid group.
D000135:Acid Phosphatase / Q000378:metabolism; D000418:Albumins / Q000378:metabolism; D000653:Amniotic Fluid / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D004343:Drug Implants; D010064:Embryo Implantation / Q000187:drug effects*; D004970:Estrone / Q000494:pharmacology; D005260:Female; D005947:Glucose / Q000378:metabolism; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology; D051381:Rats
D000418:Albumins; D004343:Drug Implants; D011460:Prostaglandins F; D004970:Estrone; D011374:Progesterone; D000135:Acid Phosphatase; D005947:Glucose; D001241:Aspirin
Untersuchungen zur Beeinflussung des Implantationsgeschehens bei Ratten und Sauen durch perorale Verabreichung von Prostaglandinsynthetasehemmern. 2. Mitteilung: Untersuchung des Einflusses von Prostaglandin F2 alpha, Progesteron/Ostron und Azetylsalizylsäure auf das Implantationsergehnis sowie einige biochemische Parameter der Amnionflüssigkeit der Ratte.