Failure of a subunit bovine herpesvirus 1 vaccine to protect against experimental respiratory disease in calves.
In two experiments in which 31 calves were used, a bovine herpesvirus 1 subunit vaccine previously shown to elicit a strong immunological response in adult cattle failed to do so in younger animals and failed to protect against pneumonia caused by sequential exposure to virulent bovine herpesvirus 1 and Pasteurella haemolytica aerosols. One of the experimental groups had been previously inoculated with a live commercial vaccine but even this failed to elicit a strong immunological response. These results indicate that the calves were in a refractory state when immunized and may explain why similar vaccine failures occur in the field.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D006564:Herpesviridae / Q000276:immunology*; D009500:Neutralization Tests; D010326:Pasteurella Infections / Q000517:prevention & control / Q000662:veterinary; D012141:Respiratory Tract Infections / Q000517:prevention & control / Q000662:veterinary*; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D014765:Viral Vaccines