Suppression by orally-administered nifedipine, nisoldipine and niludipine of early, life-threatening ventricular arrhythmias resulting from acute myocardial ischaemia.
The oral administration to rats of the calcium antagonists nifedipine, nisoldipine and niludipine (3 mg/kg, 1-1.25 h before acute coronary ligation) greatly reduced the duration of ventricular tachycardia and fibrillation (VF) occurring in the first 30 min post-ligation period. The duration of VF was especially reduced (by 74-92%). None of the animals so treated died compared with a 40% mortality in the controls.
D000818:Animals; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000209:etiology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003327:Coronary Disease / Q000150:complications / Q000188:drug therapy*; D006352:Heart Ventricles; D008297:Male; D009543:Nifedipine / Q000031:analogs & derivatives / Q000494:pharmacology*; D015737:Nisoldipine; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000889:Anti-Arrhythmia Agents; D002121:Calcium Channel Blockers; D011725:Pyridines; D015737:Nisoldipine; C019497:niludipin; D009543:Nifedipine