[Urinary N-acetyl-beta-glucosaminidase as index of renal toxicity (author's transl)].
Urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) has been studied in rats submitted to potentially nephrotoxic drugs (acetylsalicylic acid, gentamicin). Both drugs induced increase in NAG excretion which was reversible and dose-dependent. The date presented in this paper suggest that urinary NAG determination may have value as screening device for the study of nephrotoxic effects in experimental toxicology.
D000118:Acetylglucosaminidase / Q000652:urine*; D000818:Animals; D001241:Aspirin / Q000633:toxicity; D005839:Gentamicins / Q000633:toxicity; D006596:Hexosaminidases / Q000652:urine*; D007674:Kidney Diseases / Q000139:chemically induced / Q000201:enzymology*; D008297:Male; D051379:Mice
D005839:Gentamicins; D006596:Hexosaminidases; D000118:Acetylglucosaminidase; D001241:Aspirin
N-Acétyl-beta-glucosaminidase urinaire et toxicité rénale.