Febrile morbidity following cefamandole nafate intrauterine irrigation during cesarean section.
The effectiveness of intrauterine irrigation during cesarean section with a solution of cefamandole nafate in reducing febrile morbidity was studied in a prospective double-blind fashion. Ninety patients who were undergoing cesarean section at Tripler Army Medical Center were randomized into three groups: (1) intrauterine irrigation with cefamandole nafate solution, (2) intrauterine irrigation with normal saline solution, and (3) no irrigation. Febrile morbidity was evaluated by means of a fever index. There was a statistically significant reduction in the fever index in the group that received intrauterine irrigation with cefamandole nafate. The incidences of clinically diagnosed endomyometritis in the three groups were 0%, 26.7%, and 23.3%, respectively. Prophylactic intrauterine irrigation with cefamandole nafate during cesarean section markedly reduces febrile morbidity, primarily by reducing the incidence of endomyometritis.
D002435:Cefamandole / Q000008:administration & dosage / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D002585:Cesarean Section; D004311:Double-Blind Method; D004716:Endometritis / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D005334:Fever / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D007430:Intraoperative Care; D011183:Postoperative Complications / Q000517:prevention & control; D011247:Pregnancy; D011446:Prospective Studies; D011645:Puerperal Infection / Q000517:prevention & control*; D012306:Risk; D007507:Therapeutic Irrigation; D014599:Uterus
D002511:Cephalosporins; D002435:Cefamandole