Competition by meperidine for the organic cation renal excretory system.
Renal tubular excretory transport of meperidine was studied using the Sperber preparation in chickens. When urine samples from infused and uninfused kidneys were analyzed for meperidine by gas chromatography, meperidine was always present in greater amounts in the urine from the infused kidney, demonstrating active tubular excretion. Meperidine at an infusion rate of 1 mumole/min, also inhibited the excretion of the organic cations choline and acetylcholine, indicating occupation of the renal organic cation excretory system in the chicken.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active; D002412:Cations / Q000378:metabolism; D002645:Chickens; D002794:Choline / Q000378:metabolism; D006207:Half-Life; D007684:Kidney Tubules / Q000378:metabolism*; D007700:Kinetics; D008614:Meperidine / Q000378:metabolism*; D013390:Succinylcholine / Q000378:metabolism
D002412:Cations; D008614:Meperidine; D013390:Succinylcholine; D002794:Choline; D000109:Acetylcholine