Are the Jarvik artificial ventricles limited by inflow resistance?
The pneumatic total artificial heart has been assumed to be inflow limited. Mock circulation studies on the Jarvik-5 and Jarvik-7 artificial ventricles seemed to support this assumption because a Starling's response comparable to the natural heart was not achieved. Unfortunately, mock circulation studies do not separate the effects of valvular regurgitation from inflow resistance. By using a simple filling tank, filling times were determined for the Jarvik ventricles that were a function of inflow resistance alone. Theoretical maximum cardiac outputs based on these inflow resistance-dependent filling times were then calculated. For filling pressures around 5 mmHg and under modest diastolic vacuum of 5 cm H2O, the Jarvik ventricles yield a theoretical cardiac output as good as the natural heart's. Thus, inflow resistance is not a limiting factor and valvular regurgitation is left as the most likely cause of a less than optimal Starling's response on mock circulation and in vivo.
D002302:Cardiac Output; D003971:Diastole; D006339:Heart Rate; D006352:Heart Ventricles; D006354:Heart, Artificial / Q000295:instrumentation; D006801:Humans; D012212:Rheology