Aspirin-induced teratogenesis: a unique pattern of cell death and subsequent polydactyly in the rat.
Offspring of pregnant rats treated with a high dose of aspirin on day 11 of gestation frequently had predominantly right-sided polydactyly of the hindlimbs at term. Aspirin-treated embryos removed on day 12 exhibited a unique pattern of preaxial mesodermal cell death in the hindlimb buds. In addition, these embryos had a delay of the normal episode of cells death in the preaxial apical ectodermal ridge and an absence of cell death in a zone of physiological necrosis in the preaxial mesoderm thought to be instrumental in controlling preaxial digit formation. The role of cell death in the pathogenesis of polydactyly is discussed.
D000014:Abnormalities, Drug-Induced / Q000473:pathology*; D000818:Animals; D001241:Aspirin / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D046508:Culture Techniques; D004475:Ectoderm / Q000187:drug effects; D005260:Female; D006614:Hindlimb / Q000002:abnormalities* / Q000196:embryology; D008648:Mesoderm / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D013723:Teratogens
D013723:Teratogens; D001241:Aspirin