The effect of seromucoid on coagulation.
The purpose of this study was to investigate the effect on coagulation of alpha-acid-glycoprotein, one of the acute-phase reactants, the blood level of which is elevated in malignant disease and various acute conditions. Alpha-acid-glycoprotein was obtained from serum and plasma of normal volunteers. The amount obtainable from serum was greater than that obtained from plasma (43 mg/dl v. 22 mg/dl), and differences were noted in the molecular weight of the two preparations; alpha-acid-glycoprotein from serum had a molecular weight of 55 000, while that from plasma appeared to have a molecular weight of 81 000. The two preparations were identical in their reactivity towards anti-alpha-acid-glycoprotein. Alpha-acid-glycoprotein markedly shortened the partial thromboplastin time (PTT), but no effect on prothrombin index was noted. At those concentration which shortened the PTT, the preparation was able partially to reverse the anticoagulant activity of heparin. The possibility that this protein plays a role in the aetiology of coagulation disorders in cancer is discussed.
D001777:Blood Coagulation; D006801:Humans; D009961:Orosomucoid / Q000502:physiology*; D010314:Partial Thromboplastin Time; D011516:Prothrombin / Q000032:analysis
D009961:Orosomucoid; D011516:Prothrombin