Increased glutamate decarboxylase activity in the red nucleus of the adult cat after cerebellar lesions.
Glutamate decarboxylase (GAD)activity, a marker for GABAergic structures, was studied in the cat red nucleus. GAD is more concentrated in the rostral than in the caudal third of the structure. GAD levels were measured after chronic unilateral lesions of the cerebellum. Destruction of the dentate area and of the nucleus interpositus induced increases of GAD in the contralateral but not in the ipsilateral red nucleus. Similar changes also occurred in the denervated nucleus ventralis lateralis (VL) and nucleus ventralis anterior (VA) of the thalamus. Results show that loss of the excitatory cerebellar input could lead to changes in inhibitory GABAergic nerve terminals. This increase may be induced transsynaptically within existing neurons or, more likely, additional GAD-containing nerve terminals may be formed by axonal sprouting.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism*; D002415:Cats; D002531:Cerebellum / Q000502:physiology*; D004292:Dominance, Cerebral / Q000502:physiology; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D012012:Red Nucleus / Q000201:enzymology*; D013787:Thalamic Nuclei / Q000201:enzymology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D005680:gamma-Aminobutyric Acid; D002262:Carboxy-Lyases; D005968:Glutamate Decarboxylase