[Prevention of post-transfusion hepatitis. I. Evaluation of the effectiveness of donor selection by the test for HBsAg].
Two prospective controlled investigations were carried out with the use of the same procedure: in 1968-1970, when blood was not tested for HBsAg, and in 1974-1975, when only HBsAg-negative blood was used for transfusion: the presence of the antigen in the blood was determined by counter immunoelectrophoresis. The total number of hospitalized patients under observation was 37.530; of these, 13.719 patients received blood transfusion (the test group) and 23.811 patients had no blood transfusion (the control group). Posttransfusion hepatitis morbidity was determined by the difference of the morbidity rates in the test and control groups. The results thus obtained indicate that the use of HBsAg test for selection of donors in order to prevent posttransfusion hepatitis is ineffective. For this purpose epidemiologic control should be used, allowing detection of the source of infection among donors in any etiological nosoform of posttransfusion hepatitis.
D000328:Adult; D001782:Blood Donors; D002353:Carrier State / Q000175:diagnosis*; D002648:Child; D006509:Hepatitis B / Q000175:diagnosis / Q000517:prevention & control*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D065227:Transfusion Reaction
D006514:Hepatitis B Surface Antigens
Profilaktika posttransfuzionnogo gepatita. Soobshchenie I. Otsenka éffektivnosti otbora donorov po testu na HBsAg.