Comparative mutagenicity of hydrazine and 3 methylated derivatives in L5178Y mouse lymphoma cells.
The mutagenicity of hydrazine, monomethylhydrazine (MMH), 1,1-dimethylhydrazine (UDMH) and 1,2-dimethylhydrazine (SDMH) in L5178Y mouse-lymphoma cells has been investigated. Hydrazine, UDMH and SDMH induced thymidine mutation, in the absence of extraneous metabolic activation. Dose-response curves were produced for these compounds. MMH did not induce thymidine mutation. All 4 compounds were negative in the ouabain, thioguanine and cytosine arabinoside selective systems. Induction of mutation by hydrazine and UDMH is correlated with toxicity. This is not the case for SDMH-induced mutation. Hydrazine, UDMH and SDMH produce different ratios of large and small thymidine-resistant clones. The compounds appear to have different modes of action in the cell.
D000818:Animals; D006834:Hydrazines / Q000494:pharmacology* / Q000633:toxicity; D007940:Leukemia L5178 / Q000235:genetics; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D013936:Thymidine / Q000235:genetics
D006834:Hydrazines; D009153:Mutagens; D013936:Thymidine