[Pharmacological influences on the brain level and transport of GABA. I) Effect of various antipileptic drugs on brain levels of GABA].
The effects of some antipileptic drugs on the level of GABA in the mouse brain was studied using standardized chromatographic methods. Diphenylhydantoin and carbamazepine determined a marked increase of the cerebral GABA level, whereas phenobarbital, diazepam a,d clonazepam were without effect. The results seem to indicate that diphenyihydantoin and carbamazepine, by increasing the GABA level, may act through an enchancement of the GABA-ergic transmission.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002220:Carbamazepine / Q000494:pharmacology*; D002998:Clonazepam / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D051379:Mice; D010634:Phenobarbital / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D002220:Carbamazepine; D005680:gamma-Aminobutyric Acid; D002998:Clonazepam; D010672:Phenytoin; D003975:Diazepam; D010634:Phenobarbital
Influenze farmacologiche sul livello e trasporto cerebrale del GABA. - I) Effetto di alcuni farmaci antiepilettici sul livel-lo cererale del GABA.