Synthetic retinamides: effect on urinary bladder carcinogenesis by FANFT in Fischer rats.
The failure of N-ethylretinamide and N-(2-hydroxyethyl)retinamide to inhibit the incidence or severity of bladder carcinoma in female Fischer rats initiated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide supports the concept that the inhibition of bladder carcinogenesis by natural and synthetic retinoids is carcinogen-class specific.
D000818:Animals; D001835:Body Weight; D005200:FANFT / Q000037:antagonists & inhibitors* / Q000633:toxicity; D005260:Female; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control; D051381:Rats; D011916:Rats, Inbred F344; D013844:Thiazoles / Q000037:antagonists & inhibitors*; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000494:pharmacology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
D013844:Thiazoles; C009675:vitamin A acid ethylamide; C022147:N-(2-hydroxyethyl)retinamide; D014212:Tretinoin; D005200:FANFT