In vitro conjugation of the trichloroethylene metabolite trichloroethanol to a fatty acid.
Trichloroethanol (TCA), a major metabolite of the known carcinogen trichloroethylene (TCE), was shown to conjugate to palmitic acid in an in vitro rat liver coenzyme A fortified microsomal system. This conjugation of a fatty acid to one of its major metabolites may be the mechanism by which TCE is retained in the body and ultimately exerts its toxic or carcinogenic effect.
D000818:Animals; D002728:Chlorohydrins / Q000378:metabolism*; D003065:Coenzyme A / Q000378:metabolism; D005023:Ethylene Chlorohydrin / Q000031:analogs & derivatives / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D066298:In Vitro Techniques; D008861:Microsomes / Q000378:metabolism; D010169:Palmitic Acids / Q000378:metabolism; D051381:Rats; D014241:Trichloroethylene / Q000378:metabolism
D002728:Chlorohydrins; D005227:Fatty Acids; D010169:Palmitic Acids; D014241:Trichloroethylene; D005023:Ethylene Chlorohydrin; C005849:2,2,2-trichloroethanol; D003065:Coenzyme A