Effect of psoralen-induced photodermatitis on tryptophan metabolism in guinea pigs.
Tryptophan metabolism after load test, along the kynurenine pathway was studied in guinea pigs, before and during the psoralen-induced photodermatitis. This skin injury, during the acute phase, causes a large increase in urinary excretion of total metabolites and a significant increase of liver tryptophan pyrrolase.
D000818:Animals; D005260:Female; D011564:Furocoumarins / Q000633:toxicity*; D006168:Guinea Pigs; D006867:Hydrolases / Q000378:metabolism; D007737:Kynurenine / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008190:Lyases; D010787:Photosensitivity Disorders / Q000139:chemically induced / Q000378:metabolism*; D000637:Transaminases / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism*; D014366:Tryptophan Oxygenase / Q000378:metabolism
D011564:Furocoumarins; D007737:Kynurenine; D014364:Tryptophan; D014366:Tryptophan Oxygenase; D000637:Transaminases; C427605:glutamine - phenylpyruvate transaminase; C021481:kynurenine-oxoglutarate transaminase; D006867:Hydrolases; C021480:kynureninase; D008190:Lyases