Acute acoustic nerve palsy associated with vincristine therapy.
A 73-year-old woman with non-Hodgkin's lymphoma had two episodes of severe, bilateral, sensori-neural hearing loss after vincristine therapy. Her hearing gradually, then completely returned 2-3 months after the vincristine therapy was discontinued. Bilateral ear infections, central nervous system lymphoma and infection, or other drug-induced neuropathies were excluded as possible etiologies for the deafness. Bilateral acoustic (VIII) nerve palsy in this patient was most likely a manifestation of vincristine neurotoxicity.
D000368:Aged; D003638:Deafness / Q000139:chemically induced; D005260:Female; D006312:Hearing Loss, Bilateral / Q000139:chemically induced; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy*; D000159:Vestibulocochlear Nerve / Q000187:drug effects; D000160:Vestibulocochlear Nerve Diseases / Q000139:chemically induced*; D014750:Vincristine / Q000009:adverse effects*
D014750:Vincristine