A monoclonal antibody to the murine teratoma, F9: an immunocytochemical demonstration of tissue specificity.
The normal tissue distribution of the antigens recognized by a monoclonal antibody (LICR LON 28/22/23) reacting with a murine teratocarcinoma cell line and the preimplantation mouse embryo is described. The antigen(s) was found to be present in tissues derived from all the germ layers of the embryo, and to be found in the membrane and cytoplasm of cells of different tissues. In stratified and pseudostratified epithelia, of mouse and rat tissues, it was expressed only by the basal cells and it was also found on the myoepithelial cells of the lactating rat breast. In these tissues it could provide a useful marker for carcinogenesis studies.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000276:immunology; D000937:Antigen-Antibody Reactions; D000951:Antigens, Neoplasm / Q000032:analysis*; D004622:Embryo, Mammalian / Q000276:immunology; D005260:Female; D006801:Humans; D007120:Immunochemistry; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000276:immunology; D051381:Rats; D013724:Teratoma / Q000276:immunology*
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm