Gilvocarcins, new antitumor antibiotics. 1. Taxonomy, fermentation, isolation and biological activities.
Gilvocarcin V and gilvocarcin M, a group of antitumor antibiotics with a novel skeleton, were discovered in culture broths of Actinomycete DO-38. The producing organism, subsequently determined to be a new species and named Streptomyces gilvotanareus (NRRL 11382). Gilvocarcin V and M were isolated by ethyl acetate extraction and chromatography on silica gel. The antibiotics are active against Gram-positive bacteria and experimental tumors such as mouse sarcoma 180 and mouse leukemia P388.
D000190:Actinomyces / Q000145:classification / Q000502:physiology; D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D003374:Coumarins; D005285:Fermentation; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D003374:Coumarins; D006027:Glycosides; C031782:gilvocarcin M; C031781:gilvocarcin V