The effect of local anesthesia and epinephrine on the size of cryolesions in the experimental animal.
Using the pig as an experimental animal, cryolesions were made 20 minutes after injecting the freeze sites with either saline, 1% Lidocaine, or 1% lidocaine with Epinephrine 1:100,000. The size of the cryolesion was measured 1 week later by injecting the animal with a vital dye and measuring the nonstained areas with a compensating planimeter. Saline and lidocaine had no consistent effect on the size of the necrotic tissue produced by freezing, but epinephrine significantly augmented (47 percent) the killing effectiveness of cryosurgery. If local anesthesia is to be used for cryosurgery, it should contain a vasoconstricting agent.
D000772:Anesthesia, Local; D000818:Animals; D002470:Cell Survival; D003452:Cryosurgery / Q000379:methods*; D004837:Epinephrine / Q000494:pharmacology*; D008012:Lidocaine / Q000494:pharmacology; D011292:Premedication; D012867:Skin / Q000098:blood supply / Q000187:drug effects; D012965:Sodium Chloride / Q000494:pharmacology; D013552:Swine; D013997:Time Factors
D012965:Sodium Chloride; D008012:Lidocaine; D004837:Epinephrine