5-Di-(2'-tetrahydropyranyl)secalonic acid D as a new antibiotic derivative with anticancer activity.
A pyranyl derivative was chemically synthesized from secalonic acid D, an antibiotic obtained from culture filtrates of Penicillium oxalium, and its anticancer activity towards a highly antigenic rat bladder cancer, BC-47, implanted into inbred ACI/N rat was studied. The anticancer effect of the drug was similar to that of adriamycin. Delayed initiation of treatment, starting 5 days after the cancer implantation, was more effective than treatment starting from day 1. In addition, it was less effective in an immunodeficient host subsequently implanted with BC-47. This compound is thought to retard the cancer cell growth until the appearance of tumor immunity in the host.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D000917:Antibody Formation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000627:therapeutic use; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000276:immunology; D051381:Rats; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy; D014966:Xanthenes / Q000627:therapeutic use*; D044004:Xanthones
D000903:Antibiotics, Antineoplastic; D014966:Xanthenes; D044004:Xanthones; C031678:5-di-(2'-tetrahydropyranosyl)secalonic acid D; D004317:Doxorubicin