In vivo effect of 13 Leu motilin on the electric activity of the rabbit sphincter of Oddi.
Myoelectrical activity of the sphincter of Oddi was studied in 15 anaesthetized and laparotomized male rabbits, before and after injection of various doses of 13 Leucine Motilin (13 L Motilin), a biological and structural analogue of natural motilin. It can be concluded that 13 L Motilin provoked an increase of the sphincter of Oddi spike activity with doses ranging from 0.1 to 1.6 x 10(-6) g/kg. This effect had begun one minute after the injection, reached its maximum at the second minute and lasted for fifteen minutes. The action of 13 L Motilin is dose-related between 0.2 and 0.6 x 10(-6).
D014670:Ampulla of Vater / Q000187:drug effects*; D000818:Animals; D001646:Bile / Q000502:physiology; D004576:Electromyography; D004594:Electrophysiology; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D006728:Hormones / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009037:Motilin / Q000031:analogs & derivatives / Q000494:pharmacology*; D011817:Rabbits; D009803:Sphincter of Oddi / Q000187:drug effects*
D005768:Gastrointestinal Hormones; D006728:Hormones; D009037:Motilin; C013087:13-Leu-motilin