[Effect of isadrine and anaprilin on lysosomal membrane permeability of the ischemic myocardium].
Ligation of the left coronary artery of the rabbit for 2 hours induced an increase in free activity of lysosomal acid phosphatase and a decrease in its bound activity, thus indicating an elevation of the permeability of lysosomal membranes and egress of lysosomes into cell cytoplasm. Intravenous injection of isadrin (2 mg/kg) and anaprilin (25 mg/kg) favoured a significant lowering of free activity of acid phosphatase in ischemic cardiac tissue. Bound activity of acid phosphatase in the area of the ischemized myocardium was potentiated by isadrin and anaprilin. The diminished permeability of lysosomal membranes induced by isadrin and anaprilin is regarded as a nonspecific effect of the drugs.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D004789:Enzyme Activation / Q000187:drug effects; D005609:Free Radicals; D007425:Intracellular Membranes / Q000187:drug effects*; D007545:Isoproterenol / Q000627:therapeutic use*; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology*; D011433:Propranolol / Q000627:therapeutic use*; D011817:Rabbits
D005609:Free Radicals; D011433:Propranolol; D000135:Acid Phosphatase; D007545:Isoproterenol
Vliianie izadrina i anaprilina na pronitsaemost' lizosomal'nykh membran ishemizirovannogo miokarda.