Effect of neostigmine and pyridostigmine on the plasma cholinesterase activity.
The effect of neostigmine 0.05 mg kg-1 or pyridostigmine 0.25 mg kg-1 on serum cholinesterase activity was investigated in 20 adult patients undergoing elective surgery. Both drugs produced marked depression of enzymatic activity. The maximal depression was observed in samples taken 5 min after injection. The maximal percentage depression of enzymatic activity was not significantly different in the two drug groups. However, at 30-60 min after injection, the degree of depression was less in the neostigmine group. This may be attributed to the different plasma clearances of neostigmine and pyridostigmine.
D000293:Adolescent; D000328:Adult; D002800:Cholinesterase Inhibitors; D002802:Cholinesterases / Q000097:blood*; D003864:Depression, Chemical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009388:Neostigmine / Q000494:pharmacology*; D011729:Pyridostigmine Bromide / Q000494:pharmacology*; D013514:Surgical Procedures, Operative; D013997:Time Factors
D002800:Cholinesterase Inhibitors; D009388:Neostigmine; D002802:Cholinesterases; D011729:Pyridostigmine Bromide