Developmental changes in brain template active region chromatin.
The percentage of brain or liver chromatin in the template-active region was examined in rats of varying ages. Prenatally, there was an increase in the percentage of brain template-active region chromatin which declined near birth. After birth, the percentage of brain template-active region chromatin again increased to 3-6 days of age and then declined to adult levels at about 15 days of age. Liver exhibited a similar gestational change in the percentage of template-active region chromatin, but there was no recovery from the birth decline during postnatal development. These findings are discussed in terms of their contribution to the understanding of age-dependent changes in brain transcription.
D000375:Aging; D000818:Animals; D001921:Brain / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D008099:Liver / Q000378:metabolism; D008297:Male; D009562:Nissl Bodies / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D011916:Rats, Inbred F344; D013698:Templates, Genetic; D014158:Transcription, Genetic