Application of the Free-Wilson model to the analysis of the biological activities of a series of 1,6-dihydro-6-oxo-2-phenylpyrimidine antiallergy agents.
We have applied the Free-Wilson linear model to the analysis of activity data of a series of 1,6-dihydro-6-oxo-2-phenylpyrimidine derivatives which are antiallergy agents. A preliminary interpretation of the Free-Wilson coefficients, a(ij), in terms of linear free-energy related parameters suggests that biological activities in this series of compounds can be interpreted in terms of the resulting partition coefficient of the molecule, of the sum of the Hammett constants of substituents in positions 3, 4, 5 of the phenyl ring and of a dummy variable keeping into account the possibility of an intramolecular hydrogen bond.
D006967:Hypersensitivity / Q000188:drug therapy*; D008956:Models, Chemical; D011743:Pyrimidines / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D011743:Pyrimidines