[Role of natriuresis in the prophylactic effect of adaptation to hypoxia in hereditary hypertension].
It was shown in experiments on male Wistar rats and rats with spontaneous hereditary hypertension (SHH) that the development of SHH was accompanied by a significant decrease of the renal excretion of water and sodium. The acute hypoxia (the rising in the barochamber to the high altitude of 4400 m during 6 hours) in Wistar rats resulted in a significant decrease of diuresis, glomerular filtration. K and (insignificantly) Na excretion; while in SHH rats acute hypoxia increased diuresis significantly and enhanced the Na and K excretion. The adaptation to hypoxia during 6 hours per day resulted in an increase of diuresis, glomerular filtration, Na excretion and the Na/K coefficient of urine in both the animal lines. During the first month of adaptation the changes were more pronounced in SHH than in Wistar rats, as a result the hypertension did not develop in SHH rats. The relationship of the hypotensive effect of the high altitude adaptation with its natriuretic effect was shown. It is concluded that the natriuretic effect is an important and, probably, the main mechanism of the prophylactic effect of the adaptation to hypoxia on the development of hereditary hypertension.
D000222:Adaptation, Physiological; D000375:Aging; D000531:Altitude; D000818:Animals; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology / Q000517:prevention & control; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D009318:Natriuresis; D011188:Potassium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism; D013997:Time Factors
D012964:Sodium; D011188:Potassium
Rol' natriĭureza v profilakticheskom éffekte adaptatsii k gipoksii pri nasledstvennoĭ gipertonii.