[Halothane and spontaneous motility of human taenia libera in vitro (author's transl)].
Isolated human taenia libera shows spontaneous motility in the organ bath. The active basal tone, force development and frequency of spontaneous contractions and total power parameter "Montevideo Units" were first analysed under control conditions. Halothane lowered the active basal tone, frequency and the total power of the muscle strip in a dose-dependent manner. The amplitude and force of contraction of human taenia libera first began to increase under halothane, attaining its maximum at 1.0 vol.%. Halothane concentrations above 1.5 vol.% at first caused a depression and finally abolished spontaneous motility. The changes in the spontaneous motility pattern brought about by halothane were completely reversible. Possible causes for the halothane effect were considered as to the possible relevance to the in vivo situation.
D005769:Gastrointestinal Motility / Q000187:drug effects*; D006221:Halothane / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007420:Intestine, Large / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects
D006221:Halothane
Halothan und Spontanmotilität menschlicher Dickdarmtaenie in vitro.