Physiologic pharmacokinetic model of iopanoic acid metabolism in rats.
The kinetics of iopanoate metabolism have been examined using a physiologic and pharmacokinetic model in rats. The kinetics of iopanoic acid concentration in blood and in eight other major tissue distribution compartments have been determined and fitted to computer-generated concentrations based on a well-established pharmacokinetic model. The results of these studies in nonfasted, conscious rats revealed that after gastric administration of the contrast material tissue concentrations never exceed 30 microgram/g even in the liver. In addition, a clear-cut enterohepatic circulation of the drug was noted in the experimental setting and had to be incorporated into a computer-generated model to account for differences in the predicted model as compared to the experimental data. Such data point out the importance of knowledge of pharmacokinetics of a drug for development of more appropriate dosage regimens of older compounds, theoretical design and testing of new compounds, or to explain clinically observed drug-related phenomenon.
D000818:Animals; D003287:Contrast Media / Q000378:metabolism*; D005260:Female; D007480:Iopanoic Acid / Q000097:blood / Q000378:metabolism*; D007700:Kinetics; D051381:Rats; D014018:Tissue Distribution
D003287:Contrast Media; D007480:Iopanoic Acid