[Drug-induced fluorosis].
Report of a 58 year old patient who, after a 5 year continuous treatment with altogether 146 g sodium fluoride, developed a grade II-III (Roholm) fluorosis. The fluorine treatment had been conducted for a radiologically demonstrated osteoporosis. Renal involvement was not demonstrated: serum creatinine was normal, the creatinine clearance only slightly reduced. The therapeutic goal of this continuous fluoride administration, i.e. freedom from skeletal pain and vertebral stability, was not achieved; new end plate impressions of dorsal vertebrae were found.
D004305:Dose-Response Relationship, Drug; D005459:Fluorides / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000188:drug therapy*; D012969:Sodium Fluoride / Q000009:adverse effects* / Q000627:therapeutic use; D013122:Spinal Diseases / Q000139:chemically induced*
D012969:Sodium Fluoride; D005459:Fluorides
Medikamentös bedingte Fluorose.