Bilateral asymmetry in brain GABA function?
The GABA system was studied in different regions of the rat's brain following inhibition of brain GABA catabolism with intracisternal ethanolamine-O-sulphate or intraperitoneal aminooxyacetic acid. Both treatments lowered GABA aminotransferase and glutamate decarboxylase activities to similar extents in equivalent nuclei on either side of the brain. However, GABA contents were elevates to a consistently higher level in the right-hand substantia nigra, superior colliculus and nucleus accumbens, and in the left-hand ventral tegmentum, ventromedial thalamus and caudate nucleus, with no bilateral asymmetry evident in globus pallidus. These findings are discussed with reference to possible inherent inequalities in the functional states similar GABA systems on opposite sides of the brain.
D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors*; D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002262:Carboxy-Lyases / Q000378:metabolism*; D004983:Ethanolamines / Q000494:pharmacology; D007839:Functional Laterality; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D008297:Male; D051381:Rats; D000637:Transaminases / Q000037:antagonists & inhibitors*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D004983:Ethanolamines; D000625:Aminooxyacetic Acid; D005680:gamma-Aminobutyric Acid; C020619:ethanolamine O-sulfate; D000637:Transaminases; D000612:4-Aminobutyrate Transaminase; D002262:Carboxy-Lyases; D005968:Glutamate Decarboxylase