[Heterogeneity of the functional properties of macrocolonies of rat small intestine epitheliocytes].
The relationship was studied between the enzymatic activity of epitheliocyte macrocolonies of the rat small intestine and their size and the DNA synthesis rate. High degree of enzymatic differentiation was manifested by small colonies (1-4 mg) with a delayed 3H-thymidine incorporation into crypt cells. In macrocolonies sized over 5 mg with the normal DNA synthesis rate, the enzymatic differentiation was slightly marked. The evidence obtained indicates that epitheliocyte macrocolonies arising from individual stem cells have different functional properties depending on the DNA synthesis rate and the size of macrocolonies.
D000818:Animals; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D004150:Dipeptidases / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D007413:Intestinal Mucosa / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013393:Sucrase / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism
D004247:DNA; D013393:Sucrase; D004150:Dipeptidases; D013936:Thymidine
Geterogennost' funktsional'nykh svoĭstv makrokoloniĭ épiteliotsitov tonkoĭ kishki krys.