[Effect of gamma-aminobutyric acid on K+-induced and Ca++-dependent release of H3-noradrenaline from synaptosomes of the meso-diencephalic region of the rat brain].
GABA exerted no effect on H3-NA release from synaptosomes in the presence of 20 mM K+ whereas it considerably reduced the release of H3--NA evoked by 40 mM K+ ions. The omission of Ca++ ions from the superfusion fluid reduced by H3-NA release; on the other hand, GABA in this condition enhanced considerably the release of H3-NA thus exhibiting Ca++-like effect. Thus in the absence of Ca++ or in the presence of its low (1 mM) concentrations the effects of GABA on the H3--NA release from the synaptosomes was reversed.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002118:Calcium / Q000494:pharmacology*; D004027:Diencephalon / Q000378:metabolism; D004347:Drug Interactions; D066298:In Vitro Techniques; D008297:Male; D008636:Mesencephalon / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D005680:gamma-Aminobutyric Acid; D011188:Potassium; D002118:Calcium; D009638:Norepinephrine
Deĭsvie gamma-aminomaslianoĭ kisloty na K+-vyzvannoe Ca++-zavisimoe vysvobozhdenie noradrenalina-H3 iz sinaptosoma mezo-diéntsefal'noĭ oblasti mozga krys.