[Epidemiologic and clinical study of paragonimosis in Cameroon. Results of niclofolan treatment].
Paragonimiasis does not occur only in the South West Province of Cameroon. Four foci exist in the country. They are the well known focus in the Mount Kupe area, the Mbam focus, the Nyong focus and the Ntem focus. All of them are located in the rainforest within the distribution area of Potadoma. This disease, characterized by the presence of eggs in sputum and feces, has often been confused with tuberculosis. In the villages where paragonimiasis is diagnosed by means of parasitological techniques circulating antibodies, revealed with a P. westermani antigen (ELISA), are often found in blood specimens taken from inhabitants. Teen agers suffer the most from the disease and females more often than males. Women and children are traditionally concerned with crabs fishing and they eat them after partly raw. Crabs of the genus Sudanautes contain the infective metacercariae. Paragonimiasis is enzootic and the civet cat V. civetta seems to be the main natural definitive host in Cameroon. Niclofolan given orally in a single dose of 2 mg/kg body weight showed a 100% cure rate. Side reactions are mild and transient.
D002163:Cameroon; D005260:Female; D006801:Humans; D008297:Male; D009533:Niclofolan / Q000627:therapeutic use*; D009596:Nitrophenols / Q000627:therapeutic use*; D010237:Paragonimiasis / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000469:parasitology; D011859:Radiography
D009596:Nitrophenols; D009533:Niclofolan
Etude épidémiologique et clinique de la paragonimose au Cameroun. Résultats du traitement par le niclofolan.