Effects of diclofenac on lithium kinetics.
The influence of the prostaglandin (PG) synthesis-inhibiting, nonsteroidal anti-inflammatory drug (NSAID) diclofenac on lithium kinetics was studied in five normal women on a 150-mEq sodium diet. Diclofenac decreased lithium renal clearance by 23% (P - 0.002) and increased lithium plasma levels by 26% (P - 0.001). Renal PG synthesis was suppressed by 53% of control values. These data show a clinically important drug interaction, possibly on the basis of a PG-dependent mechanism, with the risk of lithium intoxication for patients treated with lithium salts and NSAIDs.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D004008:Diclofenac / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008094:Lithium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D010648:Phenylacetates / Q000494:pharmacology*; D011188:Potassium / Q000097:blood; D011453:Prostaglandins / Q000096:biosynthesis; D011674:Pulse / Q000187:drug effects; D012964:Sodium / Q000097:blood
D010648:Phenylacetates; D011453:Prostaglandins; D004008:Diclofenac; D008094:Lithium; D012964:Sodium; D003404:Creatinine; D011188:Potassium