Kit preparation of radioiodinated o-iodohippuran.
The purpose of this study ws to evaluate a kit preparation for radioiodinated o-iodohippuran (I). All ingredients, excluding the radionuclide, were packaged in a ready-to-use kit for easy, quick formulation. Electrophoresis was utilized to evaluate the radiochemical purity of the labeled product and indicated that the radiolabeling technique provided a product with greater than 95% radiochemical purity. Biodistribution studies in rats and rabbits provided an indication of the tissue distribution and localization of the radiopharmaceutical. Computer-generated renogram curves plotted from gamma-camera images of rabbits showed the equivalency of the 131I-labeled I and 123I-labeled I to the commercially available radiopharmaceutical.
D000818:Animals; D004586:Electrophoresis; D005260:Female; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid / Q000378:metabolism; D007677:Kidney Function Tests; D008297:Male; D011817:Rabbits; D051381:Rats; D011933:Reagent Kits, Diagnostic; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D011933:Reagent Kits, Diagnostic; D007465:Iodohippuric Acid