Oxytropium bromide in bronchial asthma: comparison of metered dose inhaler and powder inhalation of the anticholinergic bronchodilator oxytropium bromide in protection against acetylcholine and histamine provocation.
A marked protective effect of 0.2 mg oxytropium bromide (Ba 253), administered by inhalation, was observed against experimental provocation with a 3% acetylcholine solution. There is no difference between application by means of a metered dose inhaler or by means of powder inhalation. There is no marked protective effect of 0.2 mg oxytropium bromide administered by inhalation (aerosol or powder) against experimental provocation with a 0.3% histamine solution.
D000109:Acetylcholine / Q000037:antagonists & inhibitors*; D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000517:prevention & control*; D001985:Bronchial Provocation Tests; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006633:Histamine Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010276:Parasympatholytics / Q000008:administration & dosage / Q000627:therapeutic use*; D012602:Scopolamine Derivatives / Q000008:administration & dosage / Q000627:therapeutic use*
D001993:Bronchodilator Agents; D006633:Histamine Antagonists; D010276:Parasympatholytics; D012602:Scopolamine Derivatives; C017590:oxitropium; D000109:Acetylcholine