[Cellular mechanism of the blocking of Kupffer cell phagocytosis induced by gadolinium chloride].
Studying the distribution of heterolog erythrocytes labelled by Cr51 in rats, it was established that reticuloendothelial blockade induced by gadolinium chloride first of all can be explained by the decreased phagocytic activity of Kupffer cells. Light-and electronmicroscopic studies have evidenced that gadolinium chloride inhibited phagocytosis of indian ink not only by normal, non activated Kupffer cells but also by those, activated by a reticuloendothelial stimulator, zymosan. These experiments seem to indicate that the blockade of Kupffer cell phagocytosis induced by gadolinium chloride both phases of this process, the surface sticking and engulfing are damaged.
D000818:Animals; D005260:Female; D005682:Gadolinium / Q000494:pharmacology*; D007728:Kupffer Cells / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects*; D051381:Rats
D005682:Gadolinium
A celluláris mechanizmus vizsgálata a gadolinium kloriddal kiváltott Kupffer-sejt fagocitózis blokádban.