Hemochromatosis associated with chronic cimetidine therapy?
We report a patient in whom hemochromatosis with high transferrin saturation developed during long-term cimetidine administration. Prior reports have noted impaired iron absorption to be associated with short-term cimetidine use. The effect of chronic cimetidine administration on iron absorption and metabolism has not been studied. We believe this to be the first, and so far the only report of increased iron absorption with long-term cimetidine use.
D002927:Cimetidine / Q000009:adverse effects*; D006146:Guanidines / Q000009:adverse effects*; D006432:Hemochromatosis / Q000139:chemically induced*; D006801:Humans; D007408:Intestinal Absorption; D007501:Iron / Q000378:metabolism; D008297:Male; D008875:Middle Aged
D006146:Guanidines; D002927:Cimetidine; D007501:Iron