The effects of propylthiouracil and other drugs on the uptake of 75Se-selenomethionine by the pancreas.
The influence of pre-treatment with a variety of agents on the uptake of 75Se-selenomethionine by the rat pancreas has been studied. The agents ranged from thyroid hormones to protein synthesis inhibitors but out of 16 tested, only propylthiouracyl (50 mg/kg i.p. administered for 3 days prior to 75Se-methionine injection) resulted in a significant increase in the pancreatic uptake (17%) and in the pancreas liver concentration ratio (25%). Seven of the agents resulted in significant reductions in the pancreas/liver concentration ratios. No significant effects were produced by the addition of carrier methionine or selenomethionine (in the range 10-250 micrograms/kg body weight) to the injected radiopharmaceutical. It was concluded that many factors may influence the uptake, but that the interrelationship of hypothalamus, pituitary and pancreas is of particular interest.
D000818:Animals; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D011441:Propylthiouracil / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium / Q000378:metabolism*; D012645:Selenomethionine / Q000378:metabolism*; D013268:Stimulation, Chemical
D011441:Propylthiouracil; D012645:Selenomethionine; D012643:Selenium