Comparison of sic 'Third-Generation' tests for the detection of HBsAg.
Six 'third-generation' techniques for the detection of HBsAg were compared, i.e. Ausria II-125, Travenol-RIA, Auszyme, Hepanostika, Auscell and a modified Auscell technique applying centrifugation instead of sedimentation. The Ausria II-125 was the most sensitive test, followed by Travenol-RIA, both Auscell techniques, Auszyme and Hepanostika. In the Ausria II-125, Hepanostika and Auscell techniques, 1-2% of false-positive results were found in serum and 2% in plasma specimens from blood donors. Both the Travenol-RIA and Auszyme tests gave an unacceptably high percentage (6-8%) of false-positive results in both serum and plasma specimens.
D000017:ABO Blood-Group System / Q000032:analysis; D001782:Blood Donors; D001799:Blood Sedimentation; D002498:Centrifugation; D005189:False Positive Reactions; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D009426:Netherlands; D011863:Radioimmunoassay; D012011:Red Cross; D013223:Statistics as Topic
D000017:ABO Blood-Group System; D006514:Hepatitis B Surface Antigens