Abnormal thyroid stimulating hormone following pituitary surgery.
Biologically inactive thyroid stimulating hormone (TSH) has been reported in hypothyroid patients. We report the first case of immunoreactive, but abnormal TSH in a euthyroid patient following hypophysectomy for a prolactin secreting pituitary adenoma. Indirect evidence indicates that this abnormal TSH was biologically inactive. The TSH was characterized by gel chromatography and has a molecular weight of approximately 23,000 daltons.
D000236:Adenoma / Q000601:surgery*; D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy; D001971:Bromocriptine / Q000627:therapeutic use; D002850:Chromatography, Gel; D005260:Female; D006801:Humans; D007016:Hypophysectomy; D008970:Molecular Weight; D010911:Pituitary Neoplasms / Q000601:surgery*; D011388:Prolactin / Q000378:metabolism*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D001971:Bromocriptine; D011388:Prolactin; D013972:Thyrotropin; D013974:Thyroxine