Nonmutagenic activity of the nitroprusside.
The mutagenic activity of the pentacyanonitrosylferrate (II) (NP) was studied by the prophage induction and the Drosophila mosaic test. On the basis of plaque and mosaic spot induction freqauencies it is concluded that both NP and its adenine complex are nonmutagenic as for induction of chromosome breaks and point mutations. The nonmutagenic activity of the NP can be attributed to its nonpermeability through cell membranes.
D000818:Animals; D001435:Bacteriophages / Q000235:genetics / Q000254:growth & development; D002463:Cell Membrane Permeability; D004330:Drosophila / Q000235:genetics; D005260:Female; D005292:Ferricyanides / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D008297:Male; D009030:Mosaicism / Q000187:drug effects; D009152:Mutagenicity Tests; D009154:Mutation; D009599:Nitroprusside / Q000494:pharmacology*; D012231:Rhizobium; D014775:Virus Activation / Q000187:drug effects
D005292:Ferricyanides; D009599:Nitroprusside