[Airway response to short-term inhalation of NO2, O3 and their mixture in healthy men (author's transl)].
One hour inhalation of 0.7 ppm (1.32 mg/m3) of nitrogen dioxide (NO2), 0.7 ppm (1.4 mg/m3) of ozone (O3), and their mixture, 0.5 ppm (0.9 mg/m3) of NO2 and 0.5 ppm (1.0 mg/m3) of O3, and sham inhalation were conducted in five healthy male volunteers through mouth breathing using a multipurpose inhalation apparatus. Airway response was measured by specific airway conductance (Gaw/Vtg) and maximum expiratory flow rate at 50 and 25 percent forced vital capacity (Vmax50, Vmax25). Evaluations by analysis of variance revealed: no significant effect of inhalation of NO2 alone, slight significant transient decrease of Vmax50 in inhalation of O3 along (0.1 greater than p greater than 0.05), and slight reversible decrease of Gaw/Vtg and Vmax50 in inhalation of NO2 and O3 in combination (0.1 greater than p greater than 0.05). As their variations were within the range of normal diurnal change, these results were considered to be non-adverse effects.
D000328:Adult; D000704:Analysis of Variance; D001944:Breath Tests; D001980:Bronchi / Q000502:physiology*; D006801:Humans; D008168:Lung / Q000502:physiology*; D008297:Male; D008448:Maximal Expiratory Flow Rate; D008452:Maximum Allowable Concentration; D009585:Nitrogen Dioxide / Q000008:administration & dosage*; D010126:Ozone / Q000008:administration & dosage*; D014797:Vital Capacity
D010126:Ozone; D009585:Nitrogen Dioxide