[Beware: propafenon potentiates the effect of oral anticoagulants].
In a 68 years old female patient with premature ventricular contractions who was treated with phenprocoumon (Marcumar) because of pulmonary infarction, propafenon (Rytmonorm)--a new anti-arrhythmic drug--lead to an increased effect of coumarin. Inspite of pausing with coumarin for eight days the low Quick rates (less than 15%) did not increase until propafenon was stopped. Afterwards the coumarin treatment was continued with 1,5 to 3 mg a day. In case of a combined treatment with propafenon and coumarin Quick rates should be controlled frequently.
D000368:Aged; D000889:Anti-Arrhythmia Agents; D000925:Anticoagulants; D001780:Blood Coagulation Tests; D003374:Coumarins / Q000627:therapeutic use*; D004357:Drug Synergism; D005260:Female; D006801:Humans; D011405:Propafenone; D011427:Propiophenones / Q000627:therapeutic use*
D000889:Anti-Arrhythmia Agents; D000925:Anticoagulants; D003374:Coumarins; D011427:Propiophenones; D011405:Propafenone
Cave: Propafenon potenziert Wirkung von oralen Antikoagulantien.