[The question of "lactate alkalosis": animal experiments and a case report].
The intravenous infusion of sodium bicarbonate causes an alkalosis and an increase of lactate concentration in excess of 10 mmol/l in the experimental animal. The causal relation of alkalosis and lactic acidemia is also found in patients. A case of a therapy resistant alkalosis is demonstrated where a blood pH of 7.5 to 7.6 was correlated to a blood lactate concentration of 5 to 10 mmol/l. The normalisation of alkalosis was accompanied by a normalisation of lactate concentration to values of 1 to 2 mmol/l. The causal relation of alkalosis and increased blood lactate concentration seems to be obvious. We conclude that alkalosis is counteracted by a metabolic compensation due to the non volatile and lactic acid. Hyperlacticacidemia, therefore, is not identical with acidosis.
D000471:Alkalosis / Q000097:blood*; D000818:Animals; D001064:Appendicitis / Q000150:complications; D001639:Bicarbonates / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007773:Lactates / Q000097:blood*; D008875:Middle Aged; D008954:Models, Biological; D010538:Peritonitis / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D011188:Potassium / Q000097:blood / Q000627:therapeutic use; D051381:Rats
D001639:Bicarbonates; D007773:Lactates; D011188:Potassium
Zur Frage der Laktatalkalose: tierexperimentelle Untersuchungen und ein Fallbericht.