[Control of implantation in rats and sows by peroral administration of prostaglandin synthetase inhibitors. 3. Effects of prostaglandin F2 alpha, progesterone/estrone, and acetylsalicylic acid on implantation and biochemical composition of amniotic fluid and fetuses of young sows].
Low pregnancy rate (62.5 per cent), low implantation results (64.7 per cent), high percentage of dead foetuses (5.4 per cent), and low allantois fluid volume/foetus (130.7 ml) are likely to suggest adverse effect of prostaglandin administered in early gravidity since all these values deviate sizeably from control data (81.3, 68.0 and 1.1 per cent, 154.7 ml). On the other hand, those negative phenomena were not reflected in the results obtained from biochemical analysis of amniotic fluid and foetuses. The progesterone/oestron and acetylsalicylic acid doses used obviously had no impact upon pregnancy rates (81.3 and 75.0 per cent) and overall implantates (67.4 and 69.6 per cent), when compared to the controls (81.3 and 68.0 per cent). The lowest foetal loss occurred following application of acetylsalicylic acid (30.4 per cent, but 32.0 per cent for the controls). Increase in allantois fluid volume/foetus by progesterone/oestrone and acetylsalicylic acid was one of the findings of particular interest (progesterone/oestron: 174.4 ml, acetylsalicylic acid: 196.5 ml, control: 154.7 ml). The results obtained from amniotic fluid tests (rises in protein and progesterone concentrations) may, to some extent, suggest the possible existence of a relationship in action between the two substances. No information at all on the type of action of these substances was obtainable by biochemical analysis of foetal composition.
D000653:Amniotic Fluid / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D010064:Embryo Implantation / Q000187:drug effects*; D004970:Estrone / Q000494:pharmacology; D005260:Female; D005333:Fetus / Q000187:drug effects* / Q000378:metabolism; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology*; D013552:Swine / Q000502:physiology*
D011460:Prostaglandins F; D004970:Estrone; D011374:Progesterone; D001241:Aspirin
Untersuchungen zur Beeinflussung des Implantationsgeschehens bei Ratten und Sauen durch perorale Verabreichung von Prostaglandinsynthetasehemmern. 3. Mitteilung: Untersuchung des Einflusses von Prostaglandin F2 alpha, Progesteron/Ostron und Azetylsalizylsäure auf das Implantationsergebnis sowie die biochemische Zusammensetzung der Fruchtwässer und Feten von Jungsauen.