[The incidence of adverse effects of drugs in a pulmonary disease clinic].
In a prospective study carried out at a pulmonary clinic over a period of 14 months a side-effect rate of medicaments running to 22.67% was found out in 878 patients continuously admitted to the clinic. The acquisition of the side-effects of medicaments on the condition of a maximum patient compliance was realized by means of computer-oriented questionnaires. The 199 side-effects affected 24.18% women and 21.60% men. The highest rate of side-effects was found among women older than 61 years. 81.41% of side-effects occurred during hospital treatment, 17.51% existed already at the time of admission to hospital and 1.01% caused directly admission to hospital. The specific diseases and sarcoidoses showed the highest rate of side-effects running to 31.30%. The most frequent manifestation of side-effects was at the gastro-intestinal tract (30.48%) and at the skin (22.36%). 60.80% of the side-effects were proved to have a certain connection to medication. Most of the side-effects (56.91%) were moderately serious. According to pathogenesis toxic side-effects (47.56%) were predominant. In the treatment of pulmonary patterns of a disease 4 risk groups of medicaments with the following side-effect rate were found: antibiotics (17.51%), cytostatics (14.29%), antituberculotics (12.73%) and corticosteroids (10.53%). The side-effects of medicaments caused a prolongation of the cure per patient by 8.8 days on an average.
D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects; D000995:Antitubercular Agents / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy; D008297:Male; D010349:Patient Compliance; D011446:Prospective Studies; D012871:Skin Diseases / Q000139:chemically induced
D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D000995:Antitubercular Agents
Zur Häufigkeit von Arzneimittelnebenwirkungen an einer pulmologischen Klinik.