Effect of a prostaglandin F2 alpha analog on gastric emptying and secretion in rhesus monkeys.
The effects of 15(S)-15 methyl prostaglandin (PG) F2 alpha (mePGF2 alpha) on gastric emptying and secretion were studied in five conscious chair-adapted rhesus monkeys. A dye dilution technique was used to determine simultaneously fractional emptying rate, hydrogen ion (H+) output, fluid output and H+ concentration of the gastric juice. A continuous s.c. infusion of either saline or mePGF2 alpha (1 or 2 micrograms/kg/min) was given during a 40-min basal period and after intragastric administration of an 80-ml water load. The PGF2 alpha analog significantly inhibited both basal and postload H+ output but did not alter fluid output. As a result, the basal and postload H+ concentration of the gastric juice was significantly decreased. In addition to its antisecretory effect, mePGF2 alpha significantly enhanced postload gastric fractional emptying.
D000818:Animals; D002260:Carboprost / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism; D005746:Gastric Emptying / Q000187:drug effects*; D005750:Gastric Juice / Q000378:metabolism*; D008253:Macaca mulatta; D008297:Male; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*
D011461:Prostaglandins F, Synthetic; D002260:Carboprost