Lipid absorption in unanesthetized, unrestrained rats. Effects of 4-aminopyrazolopyrimidine and ethinyl estradiol.
Emulsified triacylglycerol containing [14C]palmitate was infused intraduodenally in unanesthetized, unrestrained animals treated with 4-aminopyrazolopyrimidine or pharmacologic doses of ethinyl estradiol. 4-Aminopyrazolo-pyrimidine practically eliminated the appearance of radioactivity in plasma but in ethinyl estradiol-treated animals the peak of radioactivity and shape of the plasma curve were similar to control, although lower in amplitude. A delayed appearance of radioactivity was also observed in 48-h- compared to 15-h-fasted controls, suggesting a requirement for induction of lipoprotein production prior to fat absorption.
D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D002784:Cholesterol / Q000097:blood; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D051381:Rats; D014018:Tissue Distribution; D014280:Triglycerides / Q000097:blood / Q000378:metabolism*
D014280:Triglycerides; C004420:4-aminopyrazolo(3,4-d)pyrimidine; D004997:Ethinyl Estradiol; D002784:Cholesterol; D000225:Adenine