Autoregulation of testosterone secretion in perfused rat testes.
Infusion of testosterone into the testicular artery, at concentrations comparable to those that occur in the testicular vein in situ, inhibited LH-stimulated testosterone secretion by rat testes perfused in vitro. This inhibition was rapid and dose responsive. In contrast to testosterone, intra-arterial infusion of 5 alpha-androstan-3 alpha, 17 beta-diol, corticosterone and androstenedione failed to inhibit testosterone secretion. The inhibition of testosterone secretion by intra-arterial infusion of testosterone was reversed by either cessation of testosterone infusion or the simultaneous addition of androstenedione to the artificial perfusion medium. Taken together, these results showed that LH-stimulated testosterone secretion by in vitro perfused rat testes was inhibited by a short-loop negative feedback of testosterone.
D000728:Androgens / Q000494:pharmacology; D000818:Animals; D003345:Corticosterone / Q000494:pharmacology; D007700:Kinetics; D007986:Luteinizing Hormone / Q000494:pharmacology; D008297:Male; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
D000728:Androgens; D013739:Testosterone; D007986:Luteinizing Hormone; D003345:Corticosterone