Long lasting suppression of firing of cortical neurons and decrease in cortical blood flow following train pulse stimulation of the locus coeruleus in the cat.
Single neuron activity and local cerebral blood flow were recorded simultaneously in the same spot of the gyrus proreus in cats. Train pulse stimulation (10-20 Hz, 30 sec) of the ipsilateral locus coeruleus induced long lasting suppression of firing in up to 78% of neurons and decrease in local flow, which lasted 1.9-5.6 min and 3.8-6.5 min, respectively. Single pulse stimulation evoked inhibition of firing in 55% of the neurons investigated.
D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000502:physiology*; D002560:Cerebrovascular Circulation; D005071:Evoked Potentials; D008125:Locus Coeruleus / Q000502:physiology*; D009433:Neural Inhibition; D009474:Neurons / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology
D009638:Norepinephrine