[Nipecotic acid, a competitive inhibitor of the net uptake of 3H-GABA by rat brain synaptosomes].
The kinetics of inhibitory effect of nipecotic acid on two different types of 3H-GABA uptake (apparent uptake by intake and net-uptake by predepolarized synaptosomes) was studied. Nipecotic acid was shown to inhibit the net-uptake of 3H-GABA by competitive route. It is concluded that analysis of inhibitory, action of a substance and of its kinetics should by performed with due regard for at least two components; homoexchange of GABA which might reach 50-60% of total radioactivity taken up and the net-uptake of the neurotransmitter.
D000042:Absorption; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D003864:Depression, Chemical; D066298:In Vitro Techniques; D009557:Nipecotic Acids / Q000494:pharmacology*; D011392:Proline / Q000031:analogs & derivatives*; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D009557:Nipecotic Acids; C030278:nipecotic acid; D005680:gamma-Aminobutyric Acid; D011392:Proline; C010983:homoproline
Nipekotovaia kislota--konkurentnyĭ ingibitor netto-zakhvata 3H-GAMK sinaptosomami mozga krys.