[Incidence, type and significance of anti-myocardial autoantibodies in patients undergoing cardiac surgery].
The incidence of anti-myocardial autoantibodies was investigated in 62 patients suffering from congenital or acquired cardiopathy prior to and 1, 10 and 20 days after cardiac surgery. Anti-myocardial autoantibodies were present in about 23.7 per cent of patients even before surgery, practically doubled one day after intervention, reached their peak (60-70 per cent) at 10 days from surgery and began to diminish at 20 days. At all times and incidence was higher in patients with acquired cardiopathy than in those with congenital heart diseases. In the large majority of cases, the autoantibodies were of the IgG class, of the striational type and in low titers. The relevance of anti-myocardial autoantibodies in the pathogenesis of cardiac lesions and the possible causes of the reversibility of the autoimmune phenomenon are discussed.
D001323:Autoantibodies / Q000032:analysis*; D006330:Heart Defects, Congenital / Q000276:immunology* / Q000601:surgery; D006331:Heart Diseases / Q000276:immunology* / Q000601:surgery; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D009206:Myocardium / Q000276:immunology*
D001323:Autoantibodies; D007074:Immunoglobulin G
Incidenza, tipoe significato degli autoanticorpi anti-miocardio in pazienti sottoposti a trattamento cardiochirurgico.