Effect of age and 2,3-DPG content of transfused blood on serum erythropoietin.
Serum erythropoietin has been measured before and after transfusion of blood stored in acid citrate dextrose for varying periods of time. A greater fall in erythropoietin was found following the transfusion of fresh blood than after an equal amount of stored blood in which 2,3-diphosphoglycerate concentrations were depleted. This confirms that expectations that in vivo tissue oxygenation is influenced by the oxygen affinity of transfused blood.
D019794:2,3-Diphosphoglycerate; D001793:Blood Preservation; D001803:Blood Transfusion; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D013997:Time Factors
D004163:Diphosphoglyceric Acids; D004921:Erythropoietin; D019794:2,3-Diphosphoglycerate; D010100:Oxygen