Perforated appendix and antibiotics.
60 consecutive children operated for perforated appendicitis were treated randomly with either penicillin and streptomycin or with clindamycin and gentamycin. Suppurative complications occurred somewhat more often and were definitely more severe in the former group. The number of hospital days spent in the treatment of these complications were three times as great in the former than in the latter group. Bacteroides fragilis could be isolated in most of the severe infections treated without clindamycin. Two out of 28 patients treated with clindamycin presented with severe diarrhoea.
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001064:Appendicitis / Q000601:surgery*; D002648:Child; D002981:Clindamycin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D007416:Intestinal Perforation / Q000601:surgery*; D010400:Penicillin G / Q000627:therapeutic use; D013307:Streptomycin / Q000627:therapeutic use; D013530:Surgical Wound Infection / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002981:Clindamycin; D010400:Penicillin G; D013307:Streptomycin