[Comparative evaluation of chronic estrone toxicity when administered by different routes].
The paper concerns the results of studying chronic toxicity of estrone injected subcutaneously in the form of oily solution and vaginal suppositoria prepared on the basis of vitepsol. It has been shown that subcutaneous administration of the drug for 2 months results in dystrophic alterations in the liver, these alterations being more pronounced than those induced by intravaginal administration of estrone in the form of suppositoria.
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D004970:Estrone / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D007279:Injections, Subcutaneous; D009929:Organ Size; D051381:Rats; D013488:Suppositories; D013997:Time Factors; D014591:Uterine Diseases / Q000139:chemically induced; D014621:Vagina; D014623:Vaginal Diseases / Q000139:chemically induced
D013488:Suppositories; D004970:Estrone
Sravnitel'naia otsenka khronicheskoĭ toksichnosti éstrona pri razlichnykh putiakh vvedeniia.