Placidyl abuse: a dimorphic picture.
Eleven patients with documented intoxication with ethchlorvynol were evaluated for clinical and laboratory manifestations. All of the 7 patients who ingested the drug were severity neurologically depressed; 3 were hemodynamically unstable and 1 developed pulmonary edema documented to be noncardiogenic 40 h after admission. All of the remaining patients (including 1 who also ingested a small amount) presented with pulmonary edema in the absence of neurological changes, soon after injection of 2--3 capsules iv; hemodynamic measurements in one of these demonstrated a noncardiogenic etiology. The clinical manifestations in these 2 groups of patients seem to be clearly separable, depending on the dose and route of administration.
D000328:Adult; D003128:Coma / Q000139:chemically induced / Q000503:physiopathology*; D004984:Ethchlorvynol / Q000008:administration & dosage / Q000506:poisoning*; D005260:Female; D006801:Humans; D008297:Male; D011654:Pulmonary Edema / Q000139:chemically induced
D004984:Ethchlorvynol