Transient induction of phenotypic resistance in human lymphoblastoid cells following sequential use of two antifolates.
D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D004334:Drug Administration Schedule; D004351:Drug Resistance; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000201:enzymology; D008727:Methotrexate / Q000008:administration & dosage*; D011739:Pyrimethamine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism; D013997:Time Factors
C006308:metoprine; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate; D011739:Pyrimethamine