Two genetically distinct forms of bipolar affective disorder?
In five pedigrees in which bipolar affective illness (BPD) can be traced through three generations with no father-son transmission, no linkage to HLA could be established. This group was evidently dependent on a single dominant gene (X-linked?), for which the noncommittal designation BPD1 was proposed. Two pedigrees of BPD, in which father-son transmission occurred at least twice, showed highly suggestive linkage to HLA (lod = 2.61 at theta = 0.15). BPD2 was proposed as the designation for this gene. Loss of BPD in one HLA-A/B cross-over suggests that a single dominant gene in this group has a locus in p2-pter region of chromosome 6.
D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008297:Male; D010375:Pedigree; D014960:X Chromosome
D006680:HLA Antigens