Association of monosomy 7 with myelodysplasia following chemotherapy for Hodgkin's disease: serial observations.
Myelodysplasia and acute nonlymphocytic leukemia following therapy for Hodgkin's disease are observed rather frequently. Herein, we describe a patient with this syndrome treated with prolonged chemotherapy (alone), having a monosomy 7 karyotype. Cytogenetic studies were performed serially during the myelodysplasia preceding overt leukemia. Review of the literature and relevance of these findings are discussed.
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000209:etiology; D008297:Male; D009196:Myeloproliferative Disorders / Q000139:chemically induced / Q000235:genetics*
D000970:Antineoplastic Agents