Amygdalin metabolism and effect on reproduction of rats fed apricot kernels.
Diets containing 10% ground apricot kernels were fed to young and breeding male and female Sprague-Dawley rats. The kernels werE obtained from 35 specific apricot cultivars and divided into groups containing low amygdalin (less than 50 mg cyanide per 100 g), moderate amygdalin (100-200 mg cyanide per 100 g), or high amygdalin (more than 200 mg cyanide per 100 g). Growth of young male rats was greatest in the low- or moderate-amygdalin group which may indicate only that they were more sensitive to the bitter taste of the kernels with high amygdalin contents. In female rats, but not males, liver rhodanese activity and thiocyanate (SCN) blood levels were increased with the high-amygdalin diet, but both male and females efficiently excreted thiocyanate, indicating efficient detoxication and clearance of cyanide hydrolyzed from the dietary amygdalin. No changes in blood chemistry were observed. Although parturition and 3-d survival indices were poor in pups from dams fed a basal semisynthetic diet, offspring of breeding rats fed the high-amygdalin diet for 18 wk had lower 3-d survival indices, lactation indices, and weaning weights than those in the low-amygdalin group. This may indicate that the cyanide present in the milk may not be efficiently detoxified to SCN and excreted by neonates.
D000678:Amygdalin / Q000009:adverse effects* / Q000378:metabolism; D000818:Animals; D005260:Female; D005638:Fruit / Q000009:adverse effects*; D006868:Hydrolysis; D008099:Liver / Q000201:enzymology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects*; D013861:Thiocyanates / Q000097:blood; D013884:Thiosulfate Sulfurtransferase / Q000032:analysis
D013861:Thiocyanates; D000678:Amygdalin; D013884:Thiosulfate Sulfurtransferase