Comparison of the effects of atropine and glycopyrrolate on lower oesophageal sphincter pressure.
Lower oesophageal sphincter pressure (LOSP) has been measured on three separate occasions in nine healthy volunteers using oesophageal pressure transducers. Atropine 0.6 mg decreased LOSP significantly at 5 min after i.v. injection (P less than 0.025) and this change was sustained for 40 min. Glycopyrrolate 0.3 mg or 0.2 mg decreased LOSP significantly at 3 min after i.v. injection (P less than 0.0025). This change was sustained for 60 min and was similar for both doses and also similar in magnitude to the change produced by atropine.
D000328:Adult; D001285:Atropine / Q000494:pharmacology*; D003864:Depression, Chemical; D004943:Esophagogastric Junction / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006024:Glycopyrrolate / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011312:Pressure; D011759:Pyrrolidines / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
D011759:Pyrrolidines; D001285:Atropine; D006024:Glycopyrrolate