The relationship between extracellular amino acids and protein synthesis is altered during axonal regeneration.
The incorporation of [3H]proline into proteins of goldfish retinal ganglion cells was measured by light microscopic autoradiography of isolated retinas that had been incubated in labeled medium under pulse-chase conditions. It was found that the composition of the immediate precursor pool for protein synthesis is more directly influenced by extracellular amino acids in regenerating cells 14 d after axotomy than in sham-operated controls.
D000818:Animals; D001369:Axons / Q000378:metabolism*; D006054:Goldfish; D007700:Kinetics; D009416:Nerve Regeneration; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009474:Neurons / Q000502:physiology*; D011392:Proline / Q000378:metabolism*; D012160:Retina / Q000502:physiology*
D009419:Nerve Tissue Proteins; D011392:Proline