Short-course (6-month) cooperative tuberculosis study in Poland: results 30 months after completion of treatment.
This final report compared the efficacy of four 6-month chemotherapy regimens 30 months after the completion of treatment. All patients received isoniazid, rifampin, and ethambutol daily in hospital for the first 8 wk of treatment. One group continued to receive these 3 drugs daily as outpatients for an additional 18 wk; a second group received the same drugs twice-weekly, and a third group received the 3 drugs once-weekly during the 18-wk "continuation phase." A fourth group of patients received 2 drugs, isoniazid and rifampin, twice-weekly during the continuation phase. Drug toxicity was not a major problem; drugs were permanently discontinued in only 1% of the patients. All 4 regimens were highly effective in achieving sputum negativity. However, the relapse rate was found to be relatively high for all regimens (range, 8 to 22%).
D000293:Adolescent; D000328:Adult; D000368:Aged; D004334:Drug Administration Schedule; D004977:Ethambutol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011044:Poland; D011859:Radiography; D012293:Rifampin / Q000627:therapeutic use*; D013183:Sputum / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000000981:diagnostic imaging / Q000188:drug therapy*
D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin