New anthracyclines, feudomycins, produced by the mutant from Streptomyces coeruleorubidus ME130-A4.
Various blocked mutants were isolated from Streptomyces coeruleorubidus ME130-A4 by NTG and UV treatments. Among them, mutant strain 4N-140 produced new anthracycline feudomycins A and B having new aglycones in which the side chain at C-9 position of daunomycinone was ethyl and acetonyl, respectively. New aglycones feudomycinones C and D having methyl at C-9 and additional groups at C-10 of daunomycinone were also isolated from this strain.
D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis*; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000032:analysis / Q000096:biosynthesis; D006868:Hydrolysis; D009154:Mutation; D010084:Oxidation-Reduction; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism*
D000900:Anti-Bacterial Agents; C031981:feudomycin B; C031980:feudomycin A; D003630:Daunorubicin