Dopamine treatment for prevention of renal failure in patients with severe eclampsia.
Nine cases with severe convulsive eclampsia, undergoing intensive care, are reported. The main problem besides sedation and anti-hypertensive therapy was to bring about diuresis. Dopamin was administered in all cases, as in particularly severe cases the application of Furosemide and osmodiuretics does not succeed in the reestablishment of diuresis. The diluted drug was administered by means of a central venous catheter in a dosage of 3 microgram/kg body weight/min. Diuresis was achieved in all patients after few hours and the values of creatinin, rest-nitrogen and creatinin-clearance restored to normal. Also the consumption coagulopathy, due to the primarily restricted function of the kidneys, which was accompanied in the most cases by low platelet and high fibrinogen values, was controlled by the mentioned therapeutic procedure. The positive therapeutic effect of Dopamin is explained by the stimulation of the postulated specific renal dopamin receptors. The discussed antagonism between Dopamin and Angiotensin could be the cause of the vascular dilatation. Thus, Dopamin has a possibly causal significance in the treatment of oligoanuric eclamptic patients.
D058186:Acute Kidney Injury / Q000517:prevention & control*; D000293:Adolescent; D000328:Adult; D004232:Diuretics / Q000627:therapeutic use*; D004298:Dopamine / Q000627:therapeutic use*; D004461:Eclampsia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D011247:Pregnancy
D004232:Diuretics; D004298:Dopamine