Three or four copies of a dicentric 17q isochromosome in an acute myeloproliferative disorder.
The majority of metaphases in the bone marrow of a male patient aged 72 with a rapidly evolving aleukemic erythremic myelosis had 48 chromosomes with three copies, or 49 chromosomes with four copies, of an i(17q), which was seen to be dicentric in C-banded and Giemsa-11-banded preparations. There was also loss of a chromosome No. 5 and the addition of a chromosome resembling a No. 22. The presence of multiple copies of the isochromosome is postulated to be related to the acuteness of the condition.
D000208:Acute Disease; D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations / Q000235:genetics*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002902:Chromosomes, Human, 16-18; D006801:Humans; D007621:Karyotyping; D008297:Male; D009196:Myeloproliferative Disorders / Q000235:genetics*