Dihydromevinolin, a potent hypocholesterolemic metabolite produced by Aspergillus terreus.
A new, potent hypocholesterolemic agent is produced by cultures of Aspergillus terreus. The isolation of the compound and its characterization as 4a,5-dihydromevinolin containing a trans-fused octahydro-naphthalene system are described. Comparative data for dihydromevinolin and mevinolin in three biological assays are given: in vitro inhibition of HMG-CoA reductase, inhibition of sterol synthesis in cell cultures, and inhibition of cholesterol synthesis in vivo in rats.
D000818:Animals; D000924:Anticholesteremic Agents / Q000378:metabolism*; D001230:Aspergillus / Q000378:metabolism*; D002784:Cholesterol / Q000096:biosynthesis; D003897:Desmosterol / Q000096:biosynthesis; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D066298:In Vitro Techniques; D008148:Lovastatin / Q000031:analogs & derivatives*; D008968:Molecular Conformation; D009281:Naphthalenes / Q000096:biosynthesis* / Q000494:pharmacology; D051381:Rats
D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D009281:Naphthalenes; D003897:Desmosterol; C031351:dihydromevinolin; D002784:Cholesterol; D008148:Lovastatin