Studies on the potential in vivo induction of sister-chromatid exchanges in rat bone marrow by resorcinol.
The hair-dye component resorcinol was tested for potential in vivo induction of sister-chromatid exchanges (SCE) in bone-marrow cells after intraperitoneal, peroral and epicutaneous application to rats. None of the tested drug concentrations produced an increase in SCE frequencies. As a control for our test method we demonstrated dose-dependent SCE increases induced by 2-acetylaminofluorene and by 2-aminoanthracene, cytogenetic response to 2-aminoanthracene being higher in females than in males.
D000284:Administration, Oral; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D003434:Crossing Over, Genetic / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens; D051381:Rats; D012118:Resorcinols / Q000008:administration & dosage / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D012867:Skin / Q000187:drug effects
D009153:Mutagens; D012118:Resorcinols