Assessment of drugs by functional imaging of thallium-201 distribution in the dog.
The effect of drugs on thallium-201 biodistribution in the body has been studied in dogs using a new functional imaging method. The calculation is based upon the comparison of the activities of the two scintigraphic images obtained after two successive injections of thallium-201 separated by an interval of at least 10 min, during which some drug of interest can be administered. This imaging technique was applied in control dogs (n = 6) and in animals treated with dipyridamole (n = 7) or grisorixin (n = 7). As expected, these two vasoactive drugs increased mainly the myocardial uptake, whereas smaller variations were noted in the other organs studied: liver, kidney, lungs, and skeletal muscles. Thus this method should allow a rapid and reliable noninvasive assessment of cardiovascular drugs with thallium-201.
D000818:Animals; D004176:Dipyridamole / Q000494:pharmacology; D004285:Dogs; D005260:Female; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009550:Nigericin / Q000031:analogs & derivatives / Q000494:pharmacology; D011868:Radioisotopes; D013793:Thallium / Q000378:metabolism*
D011868:Radioisotopes; C010731:grisorixin; D004176:Dipyridamole; D013793:Thallium; D009550:Nigericin