The formation and repair of O6-methylguanine in rat liver nucleolar DNA after dimethylnitrosamine administration studied by radioimmunoassay.
The extent of formation and the rate of repair of O6-methylguanine in rat liver nucleolar DNA following administration of a single dose of dimethylnitrosamine have been studied by means of radioimmunoassay for O6-methyldeoxyguanosine. No difference has been found in either the extent of formation or the rate of repair of this lesion between nucleolar and whole nuclear DNA.
D000818:Animals; D002466:Cell Nucleolus / Q000187:drug effects / Q000378:metabolism*; D004260:DNA Repair; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000032:analysis; D004128:Dimethylnitrosamine / Q000494:pharmacology*; D006147:Guanine / Q000031:analogs & derivatives* / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains
D006147:Guanine; C015558:O(6)-methyl-2'-deoxyguanosine; C008449:O-(6)-methylguanine; D003849:Deoxyguanosine; D004128:Dimethylnitrosamine