[Fate of lentinan (antitumor polysaccharide) II : - fast of methyl lentinan in rats (author's transl)].
3H-labeled lentinan was prepared by methylation with 3H-dimethyl-sulfate. Blood level, distribution and excretion were studied in rats. After intravenous injection of [methyl-3H] -methyl lentinan, radioactivity rapidly disappeared from blood, lung and kidney, distributed mainly in liver, spleen and mesenteric lymph nodes. There was urinary excretion, but expiratory excretion was a small proportion. In the case of multi-injection of [methyl-3H] -methyl lentinan distribution of radioactivity was similar to a single injection, but retention of 3H was less than a single injection. Bile excretion and transport to fetuses and milk were in mere trace amounts. No substantial difference was found between two types of the 3H-labeled lentinan in either the distribution or excretion.
D000818:Animals; D005260:Female; D007912:Lentinan / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D008892:Milk / Q000032:analysis; D011134:Polysaccharides / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution; D014316:Tritium
D011134:Polysaccharides; D014316:Tritium; D007912:Lentinan; C031237:methyl lentinan