Adjuvant-induced arthritis in rats: a possible animal model of chronic pain.
Adjuvant-induced arthritic rats were observed clinically and behaviorally. The clinical disease has a duration of greater than 1 month and can be divided into a pre-clinical (1-10 days), an acute (15-30 days), postacute (30-50 days) and a late phase (greater than 50 days). Adjuvant arthritis induces significantly quantitatively changes in the rats' behaviour. Two types of behavioural change merit special attention: freezing (arresting) and scratching. Freezing is significantly increased in the acute and postacute phases; it is increased by morphine, this effect being blocked by naloxone. Scratching is significantly increased in the acute, postacute and late phases; it is decreased by morphine, this effect being blocked by naloxone. The chronic presence of scratching, and the effects of morphine and naloxone on it, allow us to consider it as a possible pain-rated behaviour and therefore as a possible parameter for the study of chronic pain in animals.
D000818:Animals; D001168:Arthritis; D001169:Arthritis, Experimental; D001522:Behavior, Animal; D002908:Chronic Disease; D004195:Disease Models, Animal; D004347:Drug Interactions; D006801:Humans; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use; D009270:Naloxone / Q000008:administration & dosage; D010146:Pain / Q000188:drug therapy; D051381:Rats
D009270:Naloxone; D009020:Morphine