[Age and the effects of barbiturates on rat liver microsome oxidative enzymes].
It was shown in experiments on male white rats aged 1, 3, 6 and 25 months that the content of cytochrome P 450 and aminopyrindemethylase activity of liver microsomes decrease in old animals as compared with younger ones. No age-associated differences were revealed in old rats as compared with adult ones as regards all the parameters studied. During administration of barbiturates the induction of aminopyrindemethylase, the content of cytochromes P 450 and b5, microsomal protein and liver weight is pronounced to a far greater extent in one-month-old animals, it being decreased with age. Changes in the duration of narcotic-induced sleep (administration of barbiturates) set in earlier and are more pronounced in young animals than in adult or old ones.
D000367:Age Factors; D000633:Aminopyrine N-Demethylase / Q000378:metabolism*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D003580:Cytochromes / Q000032:analysis*; D015786:Cytochromes b5; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D010424:Pentobarbital / Q000494:pharmacology*; D010634:Phenobarbital / Q000494:pharmacology*; D011506:Proteins / Q000032:analysis; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D003580:Cytochromes; D011506:Proteins; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D000633:Aminopyrine N-Demethylase; D010424:Pentobarbital; D010634:Phenobarbital
Vozrastnye osobennosti izmeneniia fermentov mikrosomal'nogo okisleniia pecheni krys pod vliianiem barbituratov.