[Luminescent-histochemical study of the effect of atropine and dimethoxydichlorvinylphosphate on catecholamine concentration in certain rat brain structures].
Histofluorescence was used to study the effect of atropine (5 mg/kg) and dimethoxychlorvinylphosphate (DDVP, 10 mg/kg) on the content of noradrenaline (NA) and dopamine (DA) in some regions of the rat brain. The animals were sacrificed 30 minutes after administration of the drugs. It has been discovered that both atropine and DDVP increase the content of DA in the caudate nucleus and adjacent nuclei. In the NA-ergic system atropine reduces while DDVP increases the content of NA in the neurons of locus coeruleus. Interaction between the cholinergic and catecholaminergic neurotransmitter systems of the brain is discussed.
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D002421:Caudate Nucleus / Q000378:metabolism; D004006:Dichlorvos / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D006651:Histocytochemistry; D008125:Locus Coeruleus / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D013378:Substantia Nigra / Q000378:metabolism
D002395:Catecholamines; D001285:Atropine; D004006:Dichlorvos; D004298:Dopamine; D009638:Norepinephrine
Liuminestsentno-gistokhimicheskoe izuchenie vliianiia atropina i dimetoksidikhlorvinilfosfata na soderzhanie katekholaminov v nekotorykh strukturakh golovnog mozga krys.