Very high dose loxapine in refractory schizophrenic patients.
The authors report on three chronic, treatment-refractory schizophrenic patients who dramatically improved when placed on very high doses of loxapine (300-500 mg/day). Numbness transiently appeared in two patients at very high doses of loxapine; it may be a frequently occurring but unreported side effect. The relative lack of serious side effects to very high dose loxapine suggests that this may be a useful intervention in carefully selected refractory patients. The authors recommend that controlled studies be done to elucidate the benefit to risk ratio.
D000328:Adult; D003989:Dibenzoxazepines / Q000008:administration & dosage*; D006801:Humans; D008152:Loxapine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy*; D012677:Sensation / Q000187:drug effects
D003989:Dibenzoxazepines; D008152:Loxapine