[Effect of potassium orotate and the sodium salt of uridine monophosphate on the development of experimental adrenaline myocardial dystrophy].
The effect of potassium orotate in a dose of 100 mg/kg and sodium uridine monophosphate (UMP) in doses of 25, 50 and 100 mg/kg on the development of adrenaline myocardiodystrophy was studied in experiments on white rats. Preliminary administration of these drugs increases the animals' resistance to the adrenaline-induced necrotic affection of the heart. It has been noted that the animals' survival increased and the cardiac muscle status improved (according to ECG readings, biochemical findings and relative heart weight). Administration of UMP in doses of 50 and 100 mg/kg exerted a more pronounced beneficial prophylactic effect as compared with potassium orotate.
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D004562:Electrocardiography; D004837:Epinephrine / Q000037:antagonists & inhibitors*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000201:enzymology; D009963:Orotic Acid / Q000627:therapeutic use*; D051381:Rats; D014500:Uracil Nucleotides / Q000627:therapeutic use*; D014542:Uridine Monophosphate / Q000627:therapeutic use*
D014500:Uracil Nucleotides; D009963:Orotic Acid; D014542:Uridine Monophosphate; D007770:L-Lactate Dehydrogenase; D004837:Epinephrine
Vliianie kaliia orotata i natrievoĭ soli uridinmonofosfata na razvitie éxperimental'noĭ adrenalinovoĭ miokardiodistrofii.