Toxic epidermal injury following intraarterial adriamycin treatment.
Toxic epidermal injury was induced in the right forearm and thumb of a 74-year-old woman following two courses of 28 mg/m2 Adriamycin infused in the brachial artery with a three-week interval. The toxic epidermal injury was treated with a wet dressing solution and a neomycin cream without corticoids; it healed in one month. Afterwards the woman received 22 courses of Adriamycin intravenously or intraarterially in 5.5 or 11 mg/m2 doses, but the toxic epidermal injury did not occur.
D001916:Brachial Artery; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D004817:Epidermis / Q000473:pathology; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008875:Middle Aged; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology
D004317:Doxorubicin