2-hydroxyoestradiol inhibits prolactin release from the superfused rat pituitary gland.
The effects of 2-hydroxyoestradiol (2OH-OE2), dopamine, oestradiol-17 beta and 2OH-OE2 plus dopamine on prolactin and LH release from the male rat pituitary gland were examined in vitro. 2-Hydroxyoestradiol reduced prolactin secretion by 51% at 10(-10) mol/l and by 34% at 10(-7) mol/l, while oestradiol-17 beta had no effect at these doses. Dopamine alone (5 x 10(-7) mol/l) decreased prolactin released by 58%, 2OH-OE2 plus dopamine produced a similar inhibition of 60%. No significant effect on LH release was observed throughout.
D000818:Animals; D004298:Dopamine / Q000494:pharmacology; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D066298:In Vitro Techniques; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats
D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; C001390:2-hydroxyestradiol; D004298:Dopamine