[Effect of clofeline and apressin on systemic arterial pressure and the tone of cerebral and peripheral vessels].
Resistography was used to demonstrate in acute experiments on anesthetized cats that intravenous injection of clofelin (2,6 and 10 microgram/kg) and apressin (1, 2.5 and 5 microgram/kg) induced a dose-dependent decline in the arterial blood pressure which was not infrequently preceded by short-lived hypertension. Clofelin induced an increase in the tone of cerebral vessels while apressin reduced it. As regards femoral vessels both the drugs produced diverse (sometimes phasic) reactions, with vasodilation being predominant.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003000:Clonidine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004088:Dihydroergotoxine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006830:Hydralazine / Q000494:pharmacology*; D010477:Perfusion; D011433:Propranolol / Q000494:pharmacology; D014655:Vascular Resistance / Q000187:drug effects*; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents
D000959:Antihypertensive Agents; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D004088:Dihydroergotoxine; D006830:Hydralazine; D011433:Propranolol; D003000:Clonidine
Vliianie klofelina i apressina na obshchee arterial'noe davlenie, tonus mozgovykh i perifericheskikh sosudov.