[Heterocyclic systems. III. Synthesis and CNS activity of derivatives of pyrrole(2,1-c) (1,4)benzodiazocine].
5,11-Dioxo-1,2,3,5,6,11,12,12a-octahydropyrrolo [2,1-c] [1,4]benzodiazepine and the corresponding 2-hydroxyderivative were prepared by the intramolecular cyclization of 1-(2-aminophenylacetyl)pyrrolidin-2-carboxylic acid and 1-(2-aminophenylacetyl)-4-hydroxypyrrolidin-2-carboxylic acid; some of the tricyclic compounds were tested for neuropsychopharmacological effects.
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D001392:Azocines / Q000138:chemical synthesis* / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology
D000927:Anticonvulsants; D001392:Azocines; D011758:Pyrroles
Sistemi enterociclici. Nota III - Sintesi ed attività sul S.N.C. di derivati della pirrolo [2,1-c] [1,4]benzodiazocina.