[Penetration of the heparin-thromboplastin complex into brain tissues after administration of the complex into healthy animals and into animals with the prethrombotic state caused by atherogenic diet].
The possibility of heparin penetration into brain cells was shown. The penetration occurred apparently in the form of heparin complexes with thromboplastin. The intensity of penetration depended on the functional state of the anticoagulation system. Accumulation of 35S-heparin and of its complex with thromboplastin was distinctly limited in brain tissue of animals with depression of the anticoagulation system followed the long-term maintaining of the animals on an atherogenic diet.
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D004036:Diet, Atherogenic; D006493:Heparin / Q000378:metabolism*; D007700:Kinetics; D046911:Macromolecular Substances; D008297:Male; D051381:Rats; D013925:Thromboplastin / Q000378:metabolism*; D013927:Thrombosis / Q000378:metabolism*
D046911:Macromolecular Substances; D006493:Heparin; D013925:Thromboplastin
Proniknovenie kompleksa geparin--tromboplastin v tkani mozga pri ego vvededii v organizm zdorovykh zhivotnykh i zhivotnykh, nakhodiashchikhsia v predtromboticheskom sostoianii, vyzvannom aterogennoĭ dietoĭ.