The responses of I beta cells to increases in the rate of lung inflation.
The activity of inspiratory cells in the region of the nucleus of the tractus solitarius (NTS) was recorded extracellularly in paralyzed, artificially ventilated cats either during chloralose-urethane anesthesia or following midcollicular decerebration. Twenty-three of the 68 inspiratory cells recorded in the region of the NTS were classified as I beta cells on the basis of their response to withholding lung inflation. The dynamic sensitivity of I beta cells was determined by studying their response to increases in the rate of lung inflation at constant peak volume. The I beta cells in this study showed 3 distinct patterns of response to increases in the rate of inflation. Five cells showed no change in firing pattern (fixed firing pattern). Ten cells showed an increase in the rate of rise of cell activity but no change in peak frequency (low dynamic sensitivity). Eight cells showed increases in both the rate of rise of cell activity and peak frequency (high dynamic sensitivity). It was concluded that I beta cells are not a functionally homogeneous population, at least in terms of their dynamic sensitivity. Cells showing fixed firing patterns have the characteristics of off-switch neurons. Cells with low levels of dynamic sensitivity may receive afferents from pulmonary stretch receptors. Cells showing a high degree of dynamic sensitivity may receive afferents from rapidly adapting receptors. The fact that I beta cells are not a functionally homogeneous population may explain the many divergent observations reported from studies of these cells.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002415:Cats; D005071:Evoked Potentials; D005260:Female; D008168:Lung / Q000294:innervation*; D008176:Lung Volume Measurements; D008297:Male; D008465:Mechanoreceptors / Q000502:physiology*; D008526:Medulla Oblongata / Q000502:physiology*; D011661:Pulmonary Stretch Receptors / Q000502:physiology*; D011999:Recruitment, Neurophysiological; D012119:Respiration; D014630:Vagus Nerve / Q000502:physiology