Unaltered membrane properties of arterial muscle in Dahl strain genetic hypertension.
To characterize membrane properties of arterial muscle from Dahl strain hypertensive rats, we measured caudal artery contractile sensitivity to norepinephrine and serotonin, membrane potential at 16 and 37 degrees C, and intracellular potassium, sodium, and chloride content. Dahl salt-resistant (R) strain fed low- or high-salt diets and Dahl salt-sensitive (S) strain fed a low-salt diet remained normotensive. The Dahl S strain on high-salt diets became hypertensive after 4 wk of high salt feeding. There was no significant difference in the norepinephrine or serotonin effective concentration (EC) EC50, EC10, or maximum response between the hypertensive and any of the three normotensive groups. Membrane potential measured at 37 and 16 degrees C and electron-probe analysis of intracellular potassium, sodium, and chloride concentration showed no significant differences between the four groups of animals. These results that arterial muscle membrane mechanisms are not altered in genetically hypertensive Dahl salt-sensitive rats.
D000818:Animals; D001158:Arteries / Q000033:anatomy & histology*; D001794:Blood Pressure; D004195:Disease Models, Animal / Q000503:physiopathology; D005260:Female; D006973:Hypertension / Q000235:genetics*; D008564:Membrane Potentials; D008566:Membranes / Q000503:physiopathology*; D009119:Muscle Contraction; D009132:Muscles / Q000503:physiopathology*; D051381:Rats / Q000235:genetics*; D013499:Surface Properties