Amino acid composition and sequence of dermorphin, a novel opiate-like peptide from the skin of Phyllomedusa sauvagei.
Dermorphin, a heptapeptide with very potent opiate-like activity, has been isolated from methanol extracts of the skin of the South American frog Phyllomedusa sauvagei. The amino acid sequence of the peptide is: H-Try-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2. Dermorphin presents striking differences from the known enkephalins; it offers a surprising example of a peptide from Vertebrata containing a D-amino acid residue in its sequence.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001001:Anura / Q000378:metabolism*; D001681:Biological Assay; D004723:Endorphins / Q000032:analysis* / Q000302:isolation & purification; D009842:Oligopeptides / Q000032:analysis* / Q000302:isolation & purification; D018847:Opioid Peptides; D012867:Skin / Q000032:analysis*
D000596:Amino Acids; D004723:Endorphins; D009842:Oligopeptides; D018847:Opioid Peptides; C030058:dermorphin