Hemoglobin Tottori (alpha 59[E8] glycine replaced by valine).
A new electrophoretically silent, unstable hemoglobin was discovered in a Japanese family. Isolation of the abnormal chain and chemical analyses demonstrated a previously unreported amino acid substitution, alpha 59[E8] glycine replaced by Valine. The new variant has been named Hb Tottori.
D000328:Adult; D004355:Drug Stability; D004912:Erythrocytes / Q000648:ultrastructure; D005260:Female; D014644:Genetic Variation; D005998:Glycine; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D008297:Male; D008855:Microscopy, Electron, Scanning; D010375:Pedigree; D014633:Valine
D006455:Hemoglobins, Abnormal; C032025:hemoglobin Tottori; D014633:Valine; D005998:Glycine