Human prostatic adenocarcinoma: some characteristics of a serially transplantable line in nude mice (PC 82).
Transplantation of tissue from a cribriform human prostatic carcinoma resulted in a serially transplantable tumor line in nude mice, PC 82. During 2 1/2 years the tumor has not changed its histological appearance and remained a moderately differentiated adenocarcinoma. The cells contain large amounts of prostatic acid phosphatase. It has a slow rate of growth and regresses after castration and estrogen treatment. This preliminary information suggests that the PC 82 tumor line may be suitable model for hormone-dependent human prostatic cancer.
D000135:Acid Phosphatase / Q000032:analysis; D000230:Adenocarcinoma / Q000601:surgery*; D000818:Animals; D002369:Castration; D002455:Cell Division; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008854:Microscopy, Electron; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000601:surgery*; D014183:Transplantation, Heterologous
D004958:Estradiol; D000135:Acid Phosphatase