[Pharmacological influences on the brain level and transport of GABA. II) Effect of various psychoactive drugs on brain level and uptake of GABA].
The effects of some psychoactive drugs on the level and uptake of GABA in the mouse brain was studied using well standardized procedures, mainely the silica-gel cromatography for determining the GABA content and the brain slices for measuring GABA uptake. It was found that levomepromazine, sulpiride, haloperidol and amytryptiline were without effects on the cerebral level of GABA; it was also found that these drugs do not influence the rates of uptake of GABA by mouse brain slices. Such results do indicate that the psychoactive drugs studied are without effects on the level and uptake of GABA in the brain.
D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D006220:Haloperidol / Q000494:pharmacology*; D008728:Methotrimeprazine / Q000494:pharmacology*; D051379:Mice; D013469:Sulpiride / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000639:Amitriptyline; D005680:gamma-Aminobutyric Acid; D013469:Sulpiride; D008728:Methotrimeprazine; D006220:Haloperidol
Influenze farmacologiche sul livello e trasporto cerebrale del GABA. --II) Effetto di alcuni psicofarmaci sul livello e accumulo cerebrale del GABA.