Inhibition of superovulation and alteration of ova transportation in hamsters by prostaglandin and DL-204-IT, an anti-fertility agent.
The compound 2(3-ethoxyphenyl)-5, 6-dihydro-s-triazole- [5, 1-2] isoquinoline (DL-204-IT or L-11204) inhibited PMS-induced superovulation and reduced the number of recoverable ova in the oviducts of hamsters. PGE2 non-significantly reduced the number of ova shed but significantly decreased the number of oviductal ova. DL-204-IT was more potent than PGE2 for these effects. Administration of both compounds resulted in a complete block of ovulation. Inhibition of prostaglandin metabolism by DL-204-IT may be the cause for these effects, but no direct evidence is presently available.
D000818:Animals; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D005260:Female; D005298:Fertility / Q000187:drug effects; D006064:Gonadotropins, Equine / Q000494:pharmacology; D007546:Isoquinolines / Q000494:pharmacology*; D008647:Mesocricetus; D010060:Ovulation / Q000187:drug effects*; D010066:Ovum Transport / Q000187:drug effects*; D011458:Prostaglandins E / Q000494:pharmacology*; D013480:Superovulation / Q000187:drug effects*
D006064:Gonadotropins, Equine; D007546:Isoquinolines; D011458:Prostaglandins E; C014924:L 11204