Search for newer substituted phenoxyacetylethyleneimines as possible CNS, MAO and anticonvulsant agents.
Various substituted phenoxyacetic acids were converted into the acid chlorides, which react with ethyleneimine in pyridine to give the desired product. These compounds were evaluated for central nervous system (CNS) activity. Some of the compounds at a concentration of 1 . 10-3mol/l inhibited rat brain monoamine oxidase (MAO) in vitro and provided protection against pentylenetetrazole-induced convulsions in mice.
D000577:Amides / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D001388:Aziridines / Q000138:chemical synthesis*; D001389:Azirines / Q000138:chemical synthesis*; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D007928:Lethal Dose 50; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis*; D051381:Rats
D000577:Amides; D000927:Anticonvulsants; D001388:Aziridines; D001389:Azirines; D008996:Monoamine Oxidase Inhibitors