[The protective effect of vitamin E on the hepatotoxic effects of CS2 in male albino rats of Wistar strain (author's transl)].
In Vitamin E deficient rats, which had received an oral CS2 administration of the dose at 1 mg/kg following a peritoneal injection of phenobarbital sodium and a fasting period of 24 hours, histopathological changes such as vacuolar degeneration and fatty infiltration of the liver were observed along with the increases in liver weight and liver/body weight ratio. On the other hand, no such effects could be found in Vitamin E supplemented rats which otherwise received the same treatment as the Vitamin E deficient group.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002246:Carbon Disulfide / Q000506:poisoning*; D056486:Chemical and Drug Induced Liver Injury; D008099:Liver / Q000201:enzymology; D008107:Liver Diseases / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000494:pharmacology* / Q000627:therapeutic use
D014810:Vitamin E; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D002246:Carbon Disulfide