[Necrotizing enterocolitis (NEC) - pathogenesis and therapy (author's transl)].
The clinical courses in 39 children with NEC were studied to answer questions about pathogeny and the indication for surgical treatment. Anamnestic, clinical and hematological findings show an ischemia to be the "conditio sine qua non". Disseminated intravascular coagulation does not seem to be the primary cause of the disease. Whether bacterial infections of the intestinal wall are of importance in the pathogeny cannot sufficiently be proven on the available findings. The clinical symptoms, the number of platelets and the level of serum-sodium make it possible to classify NEC in four stages with typical morphologic appearance. The results of an early and of a late treatment by operation are compared and it is deduced that the best moment for surgical intervention will be the change from stage II to stage III. Symptoms of stages II/III are the progressive clinical course with increasing intestinal bleeding, edema of the abdominal wall and scrotum, thrombopenia and low sodium level.
D002648:Child; D003106:Colon / Q000473:pathology; D004761:Enterocolitis, Pseudomembranous / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007958:Leukocyte Count; D010976:Platelet Count; D011379:Prognosis
Die Nekrotisierende Enterokolitis (NEC) - Uberlegungen zur Pathogenese und Therapie.