[Supersensitivity by reserpine and means of antagonizing it].
Single or repeated reserpine application elicited in rats a supersensitivity which is measurable both by the rotation behavior and motor activity. This supersensitivity is accompanied by enhanced responsiveness to unspecific stimuli and increased responsiveness to receptor-active substances (dopamine, noradrenaline, serotonin, carbachol). Pretreatment with actinomycin D can transiently inhibit the development of supersensitivity, while repeated lithium application has no effect on it. The results give evidence for the unspecificity of reserpine-induced supersensitivity, which comprises both aminergic transmission systems and cholinergic systems and can be antagonized by inhibitors of protein synthesis.
D000818:Animals; D002217:Carbachol / Q000502:physiology; D003609:Dactinomycin / Q000037:antagonists & inhibitors; D004298:Dopamine / Q000502:physiology; D005260:Female; D005795:Generalization, Stimulus; D008094:Lithium / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D009638:Norepinephrine / Q000502:physiology; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*; D012701:Serotonin / Q000502:physiology
D003609:Dactinomycin; D012701:Serotonin; D012110:Reserpine; D002217:Carbachol; D008094:Lithium; D004298:Dopamine; D009638:Norepinephrine
Supersensitivität durch Reserpin und deren Beeinflussbarkeit.