Effect of nephrectomy on angiotensin II concentrations in plasma and hypothalamus of the dehydrated rat.
Bilateral nephrectomy in the rats deprived of water for 46 h markedly reduced plasma angiotensin II concentrations (P less than 0.001), but it was without effect on extremely low levels of the hormone in the hypothalamic tissue. These results may suggest that the activity of a possible intrinsic brain renin-angiotensin system is not influenced by that of the kidney-plasma renin-angiotensin system.
D000804:Angiotensin II / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001769:Blood; D003681:Dehydration / Q000378:metabolism*; D006400:Hematocrit; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D009392:Nephrectomy; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D014868:Water Deprivation
D000804:Angiotensin II