[Delayed asthma on diphenylmethane diisocyanate (MDI). The importance of a professional history. The utility and danger of the inhalation tests. Apropos five cases].
While asthma on toluene diisocyanate (TDI) is well known, asthma on diphenylmethane diisocyanate (MDI) has been less frequently described. Following publication of a case in 1972 another is described which was observed in a similar situation (welding of polyurethane belts) and for which the diagnosis remained obscure for some time. A questionnaire sent to factories using this type of belt revealed two other cases of asthma on MDI. A fifth case is described in which provocative testing induced severe cardiovascular disturbances within a few hours after inhalation. Following a short review of the literature, the four new cases mentioned above are presented together with spirometric studies (provocative testing) and immunological investigations.
D000368:Aged; D001249:Asthma / Q000139:chemically induced* / Q000175:diagnosis; D001559:Benzhydryl Compounds / Q000009:adverse effects*; D001985:Bronchial Provocation Tests; D003485:Cyanates / Q000009:adverse effects*; D006801:Humans; D017953:Isocyanates; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced*; D011140:Polyurethanes / Q000009:adverse effects; D013147:Spirometry; D014896:Welding
D001559:Benzhydryl Compounds; D003485:Cyanates; D017953:Isocyanates; D011140:Polyurethanes; C005969:4,4'-diphenylmethane diisocyanate
Asthme retardé au diphénylméthane-diisocyanate (MDI). Importance de l'anamnèse professionnelle. Utilité et danger des tests inhalatoires. A propos de cinq cas.