Cholesterol response in inbred strains of rats, Rattus norvegicus.
A hypercholesterolemic diet fed to rats revealed significant interstrain differences in plasma cholesterol levels. Hyperresponding and hyporesponding strains could be distinguished from normoresponding strains within 3 weeks. The increase in plasma cholesterol level was more than 300 mg/100 ml in the hyperresponding strains BN/Cpb, SD/Cpb and WE/Z and less than 50 mg/100 ml in the hyporesponding strains S3/Cpb and SHR/Cpb. These differences were primarily genetically determined: the calculated coefficient of genetic determination (g2) of the response was 0.84. The response is not correlated with variation in plasma esterase or alkaline phosphatase isozyme patterns.
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D002784:Cholesterol / Q000097:blood*; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D004950:Esterases / Q000097:blood; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains / Q000097:blood*; D013045:Species Specificity
D002791:Cholesterol, Dietary; D002784:Cholesterol; D004950:Esterases; D000469:Alkaline Phosphatase