Glucose turnover and glucose-lactate inter-relations in the newborn rat.
A technique of continuous infusion of labelled glucose and lactate was developed in the 1-day-old suckling rat, allowing the calculation of true and apparent glucose turnover and glucose-lactate inter-relations under steady-state conditions. True glucose turnover rate in suckling newborns (16.9 +/- 0.4 mg min-1 per kg body weight) was 50% higher than in fasted adult rats. A 20 +/- 3% glucose recycling was found which corresponded approximately to the Cori cycle activity. Although lactate was contributing for 25% of glucose turnover rate, this did not represent a net glucose synthesis, since more lactate was formed from glucose than glucose from lactate. However, recycling from lactate may be physiologically important as it could be the expression of a glucose sparing effect of the elevated circulating concentrations of non-esterified fatty acids and ketone bodies found in the 1-day-old suckling rat.
D000828:Animal Population Groups / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D000833:Animals, Suckling / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D005947:Glucose / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism*; D051381:Rats
D001786:Blood Glucose; D007773:Lactates; D005947:Glucose