[Effect of inducers of mixed-function microsomal oxidases on the immune response of mice induced by heterologous erythrocytes].
In experiments on male white mice immunized with sheep red blood cells the influence of various substances, differing in their chemical composition and biological activity, on the antibody titers and the number of rosette-forming cells in the spleen has been studied. These substances, acting as inductors of microsomal oxidases with mixed function (cytochrome P-450 and P-448), are phenobarbital, 3-methylcholanthrene, DDT, diphenin, rifampicin, benzodiazepin derivatives (diazepam and phenazepam). All monoxygenase activity inductors have been shown to exert a more or less pronounced immunosuppressive effect. Thus, reciprocal relations between the induction of monoxygenases and the induction of immune response have been established. The results obtained in this research are discussed from the viewpoint of the new hypothesis stating that immunity is one of the functions of the general system metabolizing chemical compounds in the body.
D000818:Animals; D014151:Anti-Anxiety Agents; D000917:Antibody Formation / Q000187:drug effects*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D003634:DDT / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004790:Enzyme Induction; D004912:Erythrocytes / Q000276:immunology; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D010634:Phenobarbital / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D012756:Sheep / Q000276:immunology
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; D008748:Methylcholanthrene; D010672:Phenytoin; D003577:Cytochrome P-450 Enzyme System; D003634:DDT; D003975:Diazepam; D012293:Rifampin; D010634:Phenobarbital
Vliianie induktorov mikrosomal'nykh oksidaz so smeshannoĭ funktsieĭ na immunnyĭ otvet mysheĭ, vyzyvaemyi geterologichnymi éritrotsitami.