[Central depletion of transmitters by reserpine and motor behavior in the rat (author's transl)].
Reserpine treatment depletes the catecholamine content in diverse parts of the brain differently. Restoring proceeds slowly with different velocities. Dopaminergic areas tend to a faster repletion than noradrenergic ones. During long-term depletion a recovery of motoric behaviour occurs. This adaptive process is not correlated with the dopamine level in caudate nucleus. The latter depends on the dosage schedule and fails in developing adaptive changes to chronic reserpine administration.
D000222:Adaptation, Physiological; D000818:Animals; D001923:Brain Chemistry; D002395:Catecholamines / Q000032:analysis; D002421:Caudate Nucleus / Q000502:physiology; D004298:Dopamine / Q000032:analysis; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*; D012110:Reserpine / Q000008:administration & dosage / Q000037:antagonists & inhibitors*
D002395:Catecholamines; D011954:Receptors, Dopamine; D012110:Reserpine; D004298:Dopamine
Zentral Transmitterdepletion durch Reserpin und motorisches Verhalten der Ratte.