[The inhibitory effect of dantrolene on the rise of serum-creatine-kinase activity after combined use of halothane and suxamethonium in man (author's transl)].
The effect of dantrolene (2 x 1 mg/kg) on the rise of serum CK activity after combined use of halothane and suxamethonium was the subject of a double-blind-study of 20 children. Dantrolene significantly inhibited the mean enzyme activity both post- and preoperatively. The incidence of suxamethonium-induced fasciculations was significantly reduced by dantrolene. Serum levels of dantrolene and its metabolites showed considerable interindividual variation; a relation between the levels and enzyme activity could not be detected. Comparing the enzyme-inhibiting effects of different methods dantrolene proved to be more effective than alcuronium preceding suxamethonium and "self-taming."
D000758:Anesthesia; D002648:Child; D003402:Creatine Kinase / Q000097:blood*; D003620:Dantrolene / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006221:Halothane / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D006801:Humans; D008297:Male; D013390:Succinylcholine / Q000009:adverse effects* / Q000037:antagonists & inhibitors
D003402:Creatine Kinase; D003620:Dantrolene; D013390:Succinylcholine; D006221:Halothane
Inhibitorische Wirkung von Dantrolene auf den Aktivitätsanstieg der Serum-CK nach gemeinsamer Anwendung von Halothan und Succinylcholin beim Menschen.