[Toxicological and radiobiological characteristics of meprin S-derivatives].
The effect was studied of synthetic thiosulfo- (TSPG), thiophospho- (TPPG), isothiuronium- (ITPG), and diethyldithiocarbamate (DDTKPG) alpha-mercaptopropionylglycine derivatives (alpha-MPG). Their toxicological and radiobiological characteristics were disclosed on mice exposed to gamma rays within a dose range of 9 to 11 Gy. TSPG in a dose of 3500 to 4500 mg/kg provided a 60 to 70% survival at LD100/10. In a dose of 4000 mg/kg the drug favoured a 70% protection of experimental animals when administered 4 hours before exposure to LD60/30. A high degree of protection (90%) was seen after TPPG preadministration (800 mg/kg) and exposure to LD100/10. DDTKPG (1300 mg/kg) also increased the survival of irradiated animals. No protective effect was observed after ITPG administration in doses of 50, 100, 180 and 360 mg/kg. Low toxicity and good enough antiradiation effect of the three compounds tested enabled the authors to proceed to more extensive studies.
D000603:Amino Acids, Sulfur / Q000633:toxicity*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005720:Gamma Rays; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011837:Radiation-Protective Agents / Q000633:toxicity*; D013997:Time Factors; D008625:Tiopronin / Q000031:analogs & derivatives / Q000633:toxicity*
D000603:Amino Acids, Sulfur; D011837:Radiation-Protective Agents; D008625:Tiopronin
Toksikologicheskaia i radiobiologicheskaia kharakteristika nekotorykh S-proizvodnykh méprina.