Aspirin inhibits Ca2+-stimulated fatty acid release from human washed platelets.
Ca2+ at 2mM concentration stimulates the release of saturated and unsaturated fatty acids from intact washed platelets incubated at 37 degrees C with stirring. Aspirin at a concentration of 0.4 mM inhibits both cyclo-oxygenase activity and fatty acid efflux induced by Ca2+. Thus, in intact washed platelets, aspirin reduces formation of cyclo-oxygenase products by direct inhibition of the enzyme and by reducing the availability of precursor arachidonate.
D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000378:metabolism*; D002118:Calcium / Q000037:antagonists & inhibitors*; D002122:Calcium Chloride / Q000037:antagonists & inhibitors; D005227:Fatty Acids / Q000097:blood*; D006801:Humans
D005227:Fatty Acids; D002122:Calcium Chloride; D001241:Aspirin; D002118:Calcium