Chemical modification of fortimicins. II. Selective protection of fortimicins A and B.
The four amino groups of fortimicin B(4) could be differentiated from each other and 2'-N-benzyloxycarbonyl-, 2',6'-di-N-benzyloxycarbonyl-, 2'-N-tert-butoxycarbonyl-, 6'-N-tert-butoxycarbonyl- and 2',6'-di-N-tert-butoxycarbonyl-fortimicin B (7, 8, 16, 18, 17) were prepared from 4. From these fortimicin B derivatives, selectively protected fortimicin A derivatives 13, 15, 21, 22 and 25 were prepared by combination of procedures of benzyloxycarbonylation or tert-butoxycarbonylation, 4-N-glycylation.
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D055598:Chemical Phenomena; D002621:Chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C023385:fortimicin B; C023384:fortimicin A