[Relation between the status of cellular immunity and pharmacologic immunocorrection of the wound process by phytohemagglutinin in rabbits].
Altogether 183 C57BL/6 mice were used to determine the optimum dose of phytohemagglutinin (PHA) to be equal to 3 microgram/g liniment tela, which reduced the time of wound healing by 33%. Experiments on 255 heterobred rabbits of both sexes revealed that the natural animal population could be distributed into three groups according to delayed type hypersensitivity (DTH) to PHA: highly sensitive, moderately sensitive and poorly sensitive, in a ratio of 1:1, 5:1. Microscopic, cytological and histological analyses have demonstrated that PHA exerts a selective therapeutic effect on wound healing. The reduction of the time required for wound healing by 38% and positive changes in cellular dynamics of inflammation have been observed only in the animals with a weak DTH to PHA. The PHA intracutaneous test is recommended for selection of patients being in want of pharmacological correction of wound healing.
D000287:Administration, Topical; D000818:Animals; D004342:Drug Hypersensitivity; D004655:Emulsions; D005260:Female; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular / Q000187:drug effects*; D008297:Male; D009824:Ointments; D010835:Phytohemagglutinins / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D012882:Skin Tests; D014945:Wound Healing / Q000187:drug effects*
D004655:Emulsions; D009824:Ointments; D010835:Phytohemagglutinins
Farmakologicheskaia immunokorrektssiia ranevogo protsessa fitogemagglutininom u krolikov v zavisimosti ot sostoianiia kletochnogo immuniteta.