Soularubinone, a new antileukemic quassionoid from Soulamea tomentosa.
The structure of soularubinone 3, a new antileukemic quassinoid isolated from the leaves of Soulamea tomentosa (Brongn, and Gris), has been established by spectral and chemical methods. It has been shown to be the C-15 beta-hydroxy-isovaleric ester of glaucarubolone. Soularubinone shows significant antineoplastic activity against mouse leukemia P-388 and inhibits cell transformation induced by Rous sarcoma virus. The known quassinoid chaparrinone I has also been isolated.
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005900:Glaucarubin / Q000031:analogs & derivatives / Q000032:analysis* / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010616:Phenanthrenes / Q000032:analysis*; D036702:Quassins
D000972:Antineoplastic Agents, Phytogenic; D010616:Phenanthrenes; D036702:Quassins; C024969:soularubinone; D005900:Glaucarubin