[Effect of hydrocortisone and cholinolytics on the resistance of rat erythrocytes to hypoosmotic hemolysis].
It was shown in experiments in vitro that hydrocortisone, gangleron and benzohexonium at a concentration of 10(-6) M increase the resistance of rat red cells to hypoosmotic hemolysis. Diplacin, d-tubocurarin, methamysil and methacin at the same concentration produce no effect on the resistance. Repeated injections of hydrocortisone to rats decrease the osmotic resistance of red cells, while diplacin and d-tubocurarin increase it. Combined use of hydrocortisone and cholinolytics made it possible to reveal the ability of diplacin and d-tubocurarin to reduce the effect of the steroid on the osmotic resistance of red cells both in vitro and in vivo.
D000818:Animals; D001535:Benactyzine / Q000031:analogs & derivatives / Q000494:pharmacology; D001565:Benzoates / Q000494:pharmacology; D002794:Choline / Q000031:analogs & derivatives / Q000494:pharmacology; D004347:Drug Interactions; D004912:Erythrocytes / Q000187:drug effects*; D006584:Hexamethonium Compounds / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D009996:Osmotic Fragility / Q000187:drug effects*; D010276:Parasympatholytics / Q000494:pharmacology*; D011763:Pyrrolizidine Alkaloids / Q000494:pharmacology; D051381:Rats; D014403:Tubocurarine / Q000494:pharmacology
D001565:Benzoates; D006584:Hexamethonium Compounds; D010276:Parasympatholytics; D011763:Pyrrolizidine Alkaloids; C004268:diplacin; C008380:metamizil; D001535:Benactyzine; C007824:ganglerone; D002794:Choline; C021628:benzohexonium; D014403:Tubocurarine; D006854:Hydrocortisone
Vliianie gidrokortizona i kholinolitikov na ustoĭchivost' éritrotsitov krys k gipoosmoticheskomu gemolizu.