Studies in an animal model on the effectiveness of adjuvant chemotherapy with 5-FU and BCNU in cases of colorectal adenocarcinoma.
The effect of combined chemotherapy with 5-FU and BCNU on ten well differentiated human adenocarcinomas of different stages following xenotransplantation and growth in syngeneic balb/c nude mice collectives was investigated. With a tumor take of approximately 90%, it was found that marked remissions up to 43% of the original volume were only obtained with those transplant tumors initially classified as Dukes A and B; carcinomas graded Dukes C/D underwent no significant remission. Pathohistological findings during tumor remission revealed large amounts of fibrotic tissue together with surviving nests of tumor cells.
D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D002330:Carmustine / Q000008:administration & dosage*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D012004:Rectal Neoplasms / Q000188:drug therapy*; D013156:Splenectomy; D014183:Transplantation, Heterologous
D005472:Fluorouracil; D002330:Carmustine