Comparison of aortic and carotid chemoreceptor responses to hypercapnia and hypoxia.
A quantitative comparison of the responses between aortic and carotid chemoreceptors to steady-state levels of arterial CO2 and O2 partial pressure was made in 35 cats anesthetized, paralyzed, and artificially ventilated. The measurements on the two receptors were made simultaneously in 6 cats and separately in 29 cats. The response of aortic chemoreceptors to a CO2 stimulus was a fraction of that of carotid chemoreceptors, and the response to hypoxia was relatively blunted. The differences between the two chemoreceptors are quantitative rather than qualitative. Since a low arterial CO2 partial pressure stimulus is known to attenuate the hypoxic response of carotid chemoreceptors, it is suggested that the low CO2 response of aortic body chemoreceptors is responsible for their blunted hypoxic response.
D000818:Animals; D001016:Aortic Bodies / Q000503:physiopathology; D002344:Carotid Body / Q000503:physiopathology; D002415:Cats; D002628:Chemoreceptor Cells / Q000503:physiopathology*; D006935:Hypercapnia / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology*