[Effect of central administration of leu-enkephalin on neurosecretory cells of the paraventricular nucleus of the hypothalamus and enterochromaffin cells of the stomach].
Administration of enkephalin into the 3rd ventricle enhanced the excitability of the paraventricular nucleus neurosecretory cells, the excitability reaching its maximum within 10 min. By the 15th min after the enkephalin administration the number of the enterochromaffin cells increases suggesting the inhibition of the secretory granules contents release into the blood. Within next 15 min the excitability of the hypothalamic neurosecretory neurons returns to its normal level. A simultaneous sharp decrease of the enterochromaffin cells occurs suggesting an endogenous activation of the secretory granules contents release.
D000818:Animals; D002452:Cell Count; D002838:Chromaffin System / Q000187:drug effects*; D004723:Endorphins / Q000494:pharmacology*; D004743:Enkephalin, Leucine; D004745:Enkephalins / Q000494:pharmacology*; D004759:Enterochromaffin Cells / Q000187:drug effects*; D005071:Evoked Potentials / Q000187:drug effects; D007031:Hypothalamus / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects*; D011706:Pyloric Antrum / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D004723:Endorphins; D004745:Enkephalins; D004743:Enkephalin, Leucine
Vliianie tsentral'nogo vvedeniia leĭ-énkefalina na neĭrosekretornye kletki paraventrikuliarnogo iadra gipotalamusa i énterokhromaffinnye kletki zheluka.