[Nerve tissue ultrastructure in experimental brain injuries in animals with increased immunobiologic reactivity following treatment with certain desensitizing drugs].
The effects of aminazin and aspirin on brain injuries in animals with immunological hypersensitivity of the body were studied. It was shown that the ultrastructural changes of the nervous tissue and the edema in the perifocal zone of the injury at early periods after ist inflicting were less marked in those animals than in sensitized animals which received no preliminary drug treatment. The capacity of aminazin and aspirin to inhibit the activity of oxidative enzymes, probably, creates conditions in which the development of the dystrophic changes is delayed. This is important for further development and course of the pathological process. Examinations of the aspirin effect under the conditions of the experiment revealed its inhibitory role in the formation of the antigen-antibody complex in the zone of the injury. Taking into account possible sensitization of the body even in clinically healthy persons one can hope that the use of desensitizing drugs may contribute to diminution of brain edema and the morphological changes resulting from surgical interventions in some diseases of the nervous system.
D000818:Animals; D001241:Aspirin / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000150:complications; D001921:Brain / Q000276:immunology* / Q000648:ultrastructure; D001929:Brain Edema / Q000517:prevention & control; D001930:Brain Injuries / Q000150:complications / Q000473:pathology / Q000628:therapy*; D002682:Chinchilla; D002746:Chlorpromazine / Q000627:therapeutic use*; D008854:Microscopy, Electron; D011817:Rabbits
D001241:Aspirin; D002746:Chlorpromazine
Ul'trastruktura nervnoĭ tkani pri éksperimental'noĭ travme mozga u zhivotnykh s povyshennoĭ immunobiologicheskoĭ reaktivnost'iu organizma pri vozdeĭstvii nekotorykh desensibiliziruiushchikh preparatov.