[Metabolism of parenterally administered amino acids in the postoperative period. I. Comparative blood kinetic examinations in healthy adults and in the postoperative period].
The postoperative and posttraumatic period is characterized by alterations of amino acid metabolism which sometimes lead to pronounced blood level imbalances. To investigate the cause of these alterations, we performed pharmacokinetic amino acid utilization studies in 20 patients on the second postoperative day and in 19 healthy adult volunteers. The results indicate that, postoperatively, the majority of amino acids exhibit prolonged half-lives and correspondingly reduced clearances. The necessity for special amino acid solutions for postoperative patients is discussed.
D000005:Abdomen / Q000601:surgery; D000328:Adult; D000596:Amino Acids / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011182:Postoperative Care
D000596:Amino Acids
Untersuchungen über die Verwertung parenteral zugeführter Aminosäuren in der postoperativen Phase. I. Vergleichende blutspiegelkinetische Untersuchungen beim gesunden Erwachsenen und in der postoperativen Phase.