Wheat gluten challenge in schizophrenic patients.
Eight chronic schizophrenic patients were maintained on a diet free of gluten, cereal grains, and milk (CM-F diet) and challenged in a double-blind manner with dietary wheat gluten and placebo. While on the CM-F diet, each patient received a daily challenge of 30 g of gluten for 5 weeks and a placebo challenge for 8 weeks. No deterioration in clinical status as measured by the BPRS was noted on gluten challenge. Serum alpha 1 acid glycoprotein measurement demonstrated no evidence of inflammatory response to gluten challenge. The data suggest that sensitivity to dietary gluten is not characteristic of young chronic schizophrenic patients.
D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005983:Glutens / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009961:Orosomucoid / Q000097:blood; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000178:diet therapy* / Q000209:etiology; D014908:Triticum
D009961:Orosomucoid; D005983:Glutens