Modification of experimental liver damage by an antiseptic: alkyldimethylbenzylammonium chloride.
Effect of Roccal (alkyldimethylbenzylammonium chloride) applications on the progress of liver recovery after damaging it by oral introduction of carbon tetrachloride (CCl4) to adult nonline rats twice a week during a month at the dosage of 0.1 ml/100 g of 50% oil solution was investigated. The Roccal applications at the dosage 10 mg/kg (1/50 DL50 skin) during a month 5 times a week intensify the functional and morphological liver damage, slows down the recovery, provokes earlier nephrotoxic effect, modifies the changes of nitrogen balance. The other phenomena of the toxic hepatopathy and the resorbtive effect of Roccal were manifested on the subcellular level by the intracellular liver hypertrophy, the damage of glycerophosphatic mitochondrial shunt, the increase of catabolism, probably the accumulation of the peroxidated products in the blood leukocytes. The changes of the leukocytes enzymatic status were aggravated by the influence of Roccal during the recovering process of the experimental hepatopathy.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology / Q000503:physiopathology; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000503:physiopathology*; D004357:Drug Synergism; D008099:Liver / Q000187:drug effects*; D008111:Liver Function Tests; D008297:Male; D000644:Quaternary Ammonium Compounds / Q000009:adverse effects*; D051381:Rats
D000644:Quaternary Ammonium Compounds