[Propranolol, triamteren and hydrochlorothiazide in fixed combinations in the treatment of hypertension (author's transl)].
The antihypertensive effect of propranolol, in fixed combinations with two dosages of triamteren and hydrochlorothiazide (Dociteren), was evaluated in a double-blind test on 19 patients with uncomplicated essential hypertension. No significant differences between the two dosages were found with respect to heart rate, as well as systolic and diastolic pressures on lying and standing up. Mean systolic and diastolic pressures were within the normotensive range with both dosages after four weeks. Increasing the diuretic component increased the type and frequency of side effects, without any additional therapeutic advantage. In seven of nine patients the previously present signs of left ventricular hypertrophy disappeared. In 9 patients the mean value of the Sokolow-Lyon index (RV5 + SV1) decreased from 4.078 mV before to 3.31 mV after an eight-week period of treatment. The results of various laboratory tests, except for a transient hyperuricaemia, did not change significantly.
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006339:Heart Rate; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011187:Posture; D011433:Propranolol / Q000627:therapeutic use*; D014223:Triamterene / Q000008:administration & dosage / Q000627:therapeutic use*; D014527:Uric Acid / Q000097:blood
D004338:Drug Combinations; D006852:Hydrochlorothiazide; D014527:Uric Acid; D011433:Propranolol; D014223:Triamterene
Propranolol, Triamteren und Hydrochlorothiazid in fixer Kombination in der Hochdrucktherapie.