[Morphological study of the effect of cholera toxin on germ-free animals].
The effect of purified cholera toxin and the O-antigen of Vibrio cholerae inoculated separately into the intestines of germ-free suckling rabbits on the structure of the viscera and enzymatic changes in them was studied. The purified cholera toxin exerted mostly a local effect on the intestinal tract but caused lesions in the lymphoid tissue. The O-antigen was toxic causing primarily lesions in the liver and kidneys. Crude cholera toxin exerted a complex effect on gnotobiotic rabbits typical of the cholerogen and O-antigen.
D000818:Animals; D000833:Animals, Suckling; D002771:Cholera / Q000473:pathology; D002772:Cholera Toxin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000494:pharmacology*; D005856:Germ-Free Life / Q000187:drug effects*; D011817:Rabbits; D014734:Vibrio cholerae
D004731:Endotoxins; D002772:Cholera Toxin
Morfologicheskoe izuchenie vliianiia khilernogo toksina na bezmikrobnykh zhivotnykh.