Addison's disease presenting as a hypercalcemic crisis in a patient with idiopathic hypoparathyroidism.
A patient with idiopathic hypoparathyroidism complicated by Addison's disease is described. The development of adrenal insufficiency was accompanied by a hypercalcaemic crisis. The hypercalcaemia appeared to result from a reduction in the filtered load and enhanced renal tubular reabsorption of calcium. Cortisone therapy was followed by the characteristic renal tubular leak of calcium associated with hypoparathyroidism and a return of the serum calcium to normal. The possible mechanisms for these changes in calcium homeostasis are discussed.
D000224:Addison Disease / Q000209:etiology*; D000293:Adolescent; D002118:Calcium / Q000378:metabolism; D003348:Cortisone / Q000627:therapeutic use; D003404:Creatinine / Q000378:metabolism; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D007011:Hypoparathyroidism / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D008297:Male
D003404:Creatinine; D002118:Calcium; D003348:Cortisone