The rapid transient stimulation of both cytoplasmic and mitochondrial ornithine decarboxylases in the liver of thyroidectomized rats by 3,5,3'-triiodo-L-thyronine.
Evidence is presented that liver from thyroidectomized rats has ornithine decarboxylase (ODC) in both mitochondrial and soluble fractions. The cytosolic activity was stimulated 7-fold and the mitochondrial activity 3-fold 15 min after the administration of triiodothyronine (T3). While the rapid transient stimulation of ODC could represent a direct intracellular response to T3, an incidental effect on a very-rapidly-turning-over enzyme seems more likely; this suggests that in vivo ODC may be controlled by a demand for polyamines.
D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism*; D003593:Cytoplasm / Q000201:enzymology; D006207:Half-Life; D008099:Liver / Q000201:enzymology*; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D051381:Rats; D013268:Stimulation, Chemical; D013965:Thyroidectomy; D014284:Triiodothyronine / Q000494:pharmacology
D014284:Triiodothyronine; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase