The effects of intracerebroventricular cycloheximide on protein synthesis and fever in rabbits.
Cycloheximide (40 micrograms) intracerebroventricularly (i.c.v.) had no effect on thermoregulation against cold, but reduced fever due to an i.c.v. injection of leucocyte pyrogen (LP) by 25%, and reduced incorporation of radioactive leucine into hypothalamic protein by 94%.
D000818:Animals; D001921:Brain / Q000378:metabolism; D003513:Cycloheximide / Q000008:administration & dosage / Q000494:pharmacology*; D005334:Fever / Q000517:prevention & control*; D007276:Injections, Intraventricular; D014176:Protein Biosynthesis; D011817:Rabbits
D003513:Cycloheximide