Effect of alloxan diabetes on the characteristics of collagen of cotton pellet granuloma and dorsal skin of Swiss mice.
Alloxan diabetes in Swiss mice of both sexes accelerated the ageing of collagen in newly formed cotton pellet granuloma concomitant with its similar effect on dorsal skin. The degree of response of collagen to alloxanization was dependent on the duration of the treatment and the sex of the animal. It is suggested that the physiologically altered state resulting from alloxanization leads to the formation of metabolites that act as promotants of collagen cross-linking in both existing and newly formed connective tissues.
D000375:Aging; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005260:Female; D003368:Gossypium; D006099:Granuloma / Q000378:metabolism*; D008297:Male; D051379:Mice; D012737:Sex Factors; D012867:Skin / Q000254:growth & development / Q000378:metabolism*
D001786:Blood Glucose; D003094:Collagen