Multihormonal control of enzyme clusters in rat liver ontogenesis. I. Effects of adrenalectomy and gonadectomy.
The role of glucocorticosteroid hormones in the developmental formation of carbamoyl-phosphate synthase, ornithine transcarbamoylase, arginase, glutamate dehydrogenase, tyrosine aminotransferase, glucose-6-phosphatase, hexokinase and glucokinase activities in rat liver was investigated. Steroid hormone producing glands were either inactivated by hypophysectomy (before birth) or removed by adrenalectomy and/or gonadectomy (after birth). These procedures strongly depressed corticosterone levels. Furthermore, they decreased enzyme activities when performed before birth or after the second postnatal week. However, adrenalectomy at 1 week of age was less effective: the developmental increases in carbamoyl-phosphate synthase, ornithine transcarbamoylase, arginase, tyrosine aminotransferase and glucose-6-phosphatase activity persisted despite the absence of increasing levels of circulating corticosterone.
D000315:Adrenalectomy; D000818:Animals; D002369:Castration; D005260:Female; D005938:Glucocorticoids / Q000502:physiology*; D007016:Hypophysectomy; D008099:Liver / Q000201:enzymology / Q000254:growth & development*; D008297:Male; D051381:Rats
D005938:Glucocorticoids