Two types of spike generation of human Auerbach's plexus cells in culture.
Cultured cells from Auerbach's plexus derived from human small intestine were used in this study. The cultured cells were classified into two types according to their morphological characteristics. Type I cells have small soma, and few processes. Type 2 cells have large soma, many processes, and form complex networks. Intracellularly applied currents cause action potentials, followed by hyperpolarizing afterpotentials. Delayed rectification was seen. The electrical properties of these cells in culture showed different types of spike generation. Action potentials of type I cells involve Ca ions and Na ions, and those of type 2 cells, Ca ions.
D002478:Cells, Cultured; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D007421:Intestine, Small / Q000294:innervation*; D008564:Membrane Potentials / Q000187:drug effects; D009197:Myenteric Plexus / Q000166:cytology / Q000502:physiology*; D013779:Tetrodotoxin / Q000494:pharmacology
D013779:Tetrodotoxin