[Mechanism of pantogam potentiation of certain effects of hexobarbital and sodium barbital and inhibition of phenamine hyperactivity].
Experiments on albino mice and rats have shown that pantogam, a derivative of pantothenic acid, potentiates the hypnotic effects of hexobarbital and barbital and enhances the effect of subthreshold doses of hexobarbital. The drug inhibits the amphetamine action in the amphetamine hyperaction test without affecting hexobarbital and amphetamine metabolism, or without increasing the blood-brain barrier permeability for these compounds and barbital. Pantogam does not influence the intensity of ethylmorphine N-demethylation in liver homogenates and the content of cytochrome P 450 and b5 in liver microsomes.
D000661:Amphetamine / Q000037:antagonists & inhibitors*; D000818:Animals; D001462:Barbital / Q000008:administration & dosage*; D001463:Barbiturates / Q000008:administration & dosage*; D001812:Blood-Brain Barrier; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006591:Hexobarbital / Q000008:administration & dosage*; D006993:Hypnotics and Sedatives; D008099:Liver / Q000378:metabolism; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D010205:Pantothenic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives*
D001463:Barbiturates; D006993:Hypnotics and Sedatives; C016030:pantogab; D010205:Pantothenic Acid; D005680:gamma-Aminobutyric Acid; D001462:Barbital; D006591:Hexobarbital; D000661:Amphetamine
K mekhanizmu potentsirovaniia pantogamom nekotorykh éffektov geksobarbitala i barbital-natriia i ingibirovaniia fenaminovoĭ giperaktivnosti.