[Antibiotic prophylaxis with cephalosporins in heart surgery].
60 minutes after i.v. injection tissue levels of 7 different cephalosporins were obtained using biological assay. The following concentrations were measured: cephalothn 1.4 micrograms/g; cepharin 4.7 micrograms/g; cephacetrile 11.2 micrograms/g; cephradine 15.4 micrograms/g; cefazedone 26.9 micrograms/g; cefamandole 40.3 micrograms/g, and finally cefoxitin 43 micrograms/g. The high tissue levels of cefamandole and cefoxitin are especially remarkable as i.v. doses of both antibiotics had been 50 mg/kg body weight ( doses of all other cephalosporins 100 mg/kg body weight). Except cephalothin, all cephalosporins tested were suitable for antibiotic prophylaxis in cardiac surgery.
D006348:Cardiac Surgical Procedures / Q000379:methods*; D002511:Cephalosporins / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D009206:Myocardium / Q000378:metabolism; D013530:Surgical Wound Infection / Q000517:prevention & control*
D002511:Cephalosporins
Antibiotika-Prophylaxe in der Herzchirurgie mit Cephalosporinen.