[Contribution to the determination of four antimalarial molecules (chloroquine, quinine, pyrimethamine, sulfadoxime) mixed in biological fluids. I. Spectrophotometry UV (author's transl)].
Antimalarial therapy is directed more and more towards the use of associated substances: Pyrimethamine, sulfadoxime, quinine et chloroquine. The authors propose a method of direct determination of these four molecules mixed in biological fluids. The recommended extraction process followed by a spectrophotometric UV determination is fast, reproductible and sufficiently sensitive to study the evolution of a therapy.
D000962:Antimalarials / Q000032:analysis*; D002738:Chloroquine / Q000032:analysis; D011739:Pyrimethamine / Q000032:analysis; D011803:Quinine / Q000032:analysis; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013413:Sulfadoxine / Q000032:analysis
D000962:Antimalarials; D013413:Sulfadoxine; D002738:Chloroquine; D011803:Quinine; D011739:Pyrimethamine
Contribution au dosage de quatre antipaludéens (chloroquine, quinine, pyriméthamine, sulfadoxime) I. Spectrophotométrie UV.