Pharmacokinetics of oxfendazole in sheep.
Pharmacokinetics of oxfendazole and its sulfone metabolite were determined in 6 sheep. Oxfendazole achieved mean peak plasma concentrations of 0.76 micrograms/ml at 30 hours after oral administration of oxfendazole (10 mg/kg of body weight), and concentrations were detectable for up to 7 days after administration. Mean peak abomasal concentrations of 3.55 micrograms/ml occurred 20 hours after administration and were detectable up to 9 days after administration. Concentrations of sulfone in plasma and abomasal fluid were generally lower than were those of oxfendazole.
D000018:Abomasum / Q000378:metabolism; D000818:Animals; D000871:Anthelmintics / Q000097:blood / Q000378:metabolism*; D001562:Benzimidazoles / Q000097:blood / Q000378:metabolism*; D002219:Carbamates / Q000097:blood / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D008297:Male; D012417:Rumen / Q000378:metabolism; D012756:Sheep / Q000378:metabolism*
D000871:Anthelmintics; D001562:Benzimidazoles; D002219:Carbamates; C031608:oxfendazole sulfone; C011030:oxfendazole