The influence of taurine on acetylcholine content and synthesis in rat brain.
Taurine applied to rats intracerebroventricularly in doses 0.1--3.0 mg increased ACh level and decreased ACh synthesis in the cerebral cortex. In the striatum ACh level was increased after doses of 0.1--3.0 mg and ACh synthesis was decreased after 0.01--3.0 mg. In the hippocampus taurine appeared to decrease both ACh level (0.5--3.0 mg) and synthesis (0.1--3.0 mg). Maximum effects of taurine were observed 30--60 min following the injection. A possible role of taurine as a neurotransmitter or neuromodulator is discussed.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical; D013654:Taurine / Q000008:administration & dosage / Q000494:pharmacology*
D013654:Taurine; D000109:Acetylcholine