Validation of a computer-assisted method for estimating the number and volume of gallstones visualized by cholecystography.
It is likely that in the near future there will be widespread use of medicinal therapy to dissolve gallstones. The efficacy of medicinal therapy can best be determined by attempting to relate the total surface area of a collection of gallstones to the composition of bile in patients undergoing therapy. Surface area, in turn, can be directly related to gallstone size and number. In this study, involving 48 cholecystectomized patients, we have shown that standard cholecystography, together with a computer-assisted method of metrology, can effectively monitor the above parameters. Determinations of the standard deviation of 1) replicate readings (35.8%) and 2) averaged metrology estimates compared with actual stone volumes (42.9%), as well as correlation of actual stone volumes with averaged metrology estimates (r = 0.961), indicated the magnitude of assessed change in stone volume that would be necessary to accept a roentgenographic decrease or increase in stone size with 95% confidence. Even with the increased precision found in the computer-assisted method as described, to attain a 98% certainty of some volume change it was necessary to have metrology volume change of 50% or more. Actual stone counts were without significant error in 87.5% of the determinations.
D002635:Chenodeoxycholic Acid / Q000627:therapeutic use; D002765:Cholecystography / Q000379:methods*; D002769:Cholelithiasis / Q000000981:diagnostic imaging* / Q000188:drug therapy; D003201:Computers; D006801:Humans
D002635:Chenodeoxycholic Acid