Interference of glucosamine and other aminosugars on blast transformation.
The effect of exogenous glucosamine and other aminosugars on the incorporation of 3H-leucine 3H-uridine and 3H-thymidine into mitogen induced lymphocytes was studied. D-glucosamine D-galactosamine and D-mannosamine inhibit the incorporation of these precursors into protein. RNA and DNA of blast cells. Glucose and pyruvate did not reverse this inhibition. Glucosamine - 6P, acetylglucosamine and acetylglucosamine and have shown a considerably lower inhibition in the uptake of these labeled precursors.
D005944:Glucosamine / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D006595:Hexosamines / Q000494:pharmacology; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D011773:Pyruvates / Q000494:pharmacology; D019289:Pyruvic Acid
D006595:Hexosamines; D011773:Pyruvates; D019289:Pyruvic Acid; D005947:Glucose; D005944:Glucosamine