Effects of amiloride and SITS on branchial ion fluxes in rainbow trout, Salmo gairdneri.
The effects of amiloride and SITS on branchial ion fluxes in rainbow trout were examined. Each drug was found significantly to inhibit both influx of Na+ and Cl- ions. It is postulated that the inhibitory effects on the contralateral exchange processes result from changes in gill epithelial cell pH.
D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / Q000494:pharmacology*; D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport; D002712:Chlorides / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D005880:Gills / Q000187:drug effects / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D011719:Pyrazines / Q000494:pharmacology*; D013267:Stilbenes / Q000494:pharmacology*; D014337:Trout
D002712:Chlorides; D011719:Pyrazines; D013267:Stilbenes; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; D000584:Amiloride