[Familial multiple naevogene melanomas. Electronmicroscopical findings in pigmented moles of the B-K-mole syndrome (author's transl)].
Report of a patient with familial melanocytic moles and melanomas as designated by Clark et al. as B-K-mole-syndrome. Beside the typical clinical and histological features, the ultrastructural changes of B-K-moles are described. Nevus cells in these moles showed lobed nuclei, active Golgi complexes and swollen mitochondriae. Membrane rich melanosomes and melanosome complexes were found. The B-K-moles had no distinctive ultrastructure. An ultrastructural differentiation between tumor cells of the B-K-moles and melanoma cells was not possible.
D000328:Adult; D002467:Cell Nucleus / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008544:Melanocytes / Q000648:ultrastructure; D008545:Melanoma / Q000235:genetics* / Q000648:ultrastructure; D008854:Microscopy, Electron; D009508:Nevus, Pigmented / Q000235:genetics* / Q000648:ultrastructure; D010375:Pedigree; D012867:Skin / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000235:genetics* / Q000648:ultrastructure; D014617:Vacuoles / Q000648:ultrastructure
Familiäre multiple naevogene Melanome. Elektronenoptische Befunde bei prämalignen Pigmentmälern des B - K Mole-Syndroms.