[Antimutagenic properties of a series of drug compounds].
Caffeine, hexamidine, Lm8, methionine, ATP, ionol, and vitamin E enhance the proliferation of the normal embryonic culture of human fibroblasts. Arginine, streptomycin and cysteamine exert no action on the growth of the culture. Analysis of similar effects on the culture of xeroderma pigmentosum has demonstrated that caffeine, hexamidine, Lm3 and vitamin E also enhance the proliferation of the culture. Ionol produces no effect on the culture of xeroderma pigmentosum. The mutagenic agent dioxidine causes a sharp inhibition of the proliferation of normal embryonic culture and has no effect on the culture of xeroderma pigmentosum
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D009153:Mutagens; D009154:Mutation / Q000187:drug effects*; D011810:Quinoxalines / Q000494:pharmacology; D014983:Xeroderma Pigmentosum / Q000188:drug therapy
D009153:Mutagens; D011810:Quinoxalines; C001077:dioxidine
Izuchenie antimutagennykh svoĭstv riada lekarstvennykh soedineniĭ.