Motor interaction between cimetidine and cholecystokinin-related peptides in the gall bladder.
In vitro cimetidine (10(-5) g/ml), an antagonist of H2-histamine receptors, caused an augmentation of the contractile effects of histamine (10(-8) - 10(-6) g/m) and caerulein (10(-10) - 10(-8) g/ml) on isolated guinea-pig gall bladder. Also in vivo pretreatment of anesthetized dogs with cimetidine (3 mg/kg) induced an increase of the motor response of the gall bladder to Boots pancreozymin (0.5-5.0 CHR U/kg). These results confirm the existence of relaxing effect of H2 -- receptors in musculature of the gall bladder which can modify the contractile action of cholecystokinin-related peptides.
D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology*; D002927:Cimetidine / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D005704:Gallbladder / Q000187:drug effects*; D006146:Guanidines / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology
D006146:Guanidines; D010455:Peptides; D002927:Cimetidine; D002766:Cholecystokinin