[Effect of pressure and local adrenaline application on carotid sinus on the perfusion pressure in the perfused hindlimb].
On anaesthetized dogs the response of the perfusion pressure of a volume-constant perfused hindlimb and of the systemic arterial blood pressure during mechanical stimulation of the sinual baroreceptors, resulting in a rectangular increase in the intrasinual pressure and during local application of adrenaline at both carotid sinus bifurcations was determined, leaving the vagoaortic trunks intact. The mechanical stimulation of the sinual baroreceptors as well as the local application of adrenaline induced a pronounced decrease in the perfusion associated with a simultaneous fall in the systolic and diastolic blood pressure. The maximal decrease in systolic blood pressure at both types of stimulation was similar, however, the maximal fall in the perfusion pressure after application of adrenaline was less than that after rectangular mechanical stimulation of the sinual baroreceptors. A decrease in the heart rate after application of adrenaline was not observed. The mechanical stimulation of sinual baroreceptors before or after local application of adrenaline resulted in a similar decrease in the perfusion pressure of the perfused hindlimb.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002346:Carotid Sinus / Q000187:drug effects* / Q000502:physiology; D004285:Dogs; D004837:Epinephrine / Q000494:pharmacology*; D005263:Femoral Artery / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D006614:Hindlimb / Q000098:blood supply*; D010477:Perfusion; D011311:Pressoreceptors / Q000187:drug effects* / Q000502:physiology; D011312:Pressure
D004837:Epinephrine
Uber den Einfluss der Karotissinusdruckbelastung und der lokalen Adrenalinapplikation am Karotissinus auf den Perfusionsdruck der durchströmten Hinterextremität des Hundes.