Development of coloboma (Cm/+), a mutation with anterior lens adhesion.
A semidominant mutation in the laboratory mouse, Coloboma (Cm), is described. Coloboma is located on Chromosome 2, as is the similar mutation Dickie's small eye (Dey). Coloboma has a moderately reduced expressivity. The anterior chamber is usually present in Cm/+. Both Cm and Dey show delayed detachment of the lens vesicle and microphthalmia, and homozygotes of both apparently die early in pregnancy.
D000818:Animals; D003103:Coloboma / Q000235:genetics* / Q000473:pathology; D003433:Crosses, Genetic; D006579:Heterozygote; D006720:Homozygote; D007908:Lens, Crystalline / Q000002:abnormalities; D051379:Mice; D008817:Mice, Mutant Strains; D008850:Microphthalmos / Q000150:complications