Thyroid hormone changes in obese subjects during fasting and a very-low-calorie diet.
Total fasting was compared with VLCD (1.28 MJ, 300 kcal/day; 56 g protein, 12 g CHO) in 14 euthyroid obese patients, selected as matched pairs, over a period of 28 days. The weight loss was significantly greater during fasting than during the VLCD (16.5 kg vs. 12.7 kg). The basal metabolic rate of (BMR) showed a significant decrease (25 per cent) during total fasting, but was unchanged with the VLCD. With both diets there was a transient increase in T4, FT4 and FT4I, and a tendency for TSH to decrease. There was a decrease in T3 and a transient increase in rT3. Nitrogen balance was attained in five of seven patients on the VLCD after four weeks.
D000328:Adult; D001481:Basal Metabolism; D001835:Body Weight; D004038:Diet, Reducing; D005215:Fasting; D005260:Female; D006801:Humans; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D009765:Obesity / Q000097:blood* / Q000178:diet therapy; D013963:Thyroid Hormones / Q000097:blood*; D013997:Time Factors
D013963:Thyroid Hormones; D009584:Nitrogen