[Harmful chemical agents in electrochemical processing. II. Experimental studies on the toxic effects of nitric oxide and chlorine. Changes in peripheral blood in rats].
In rats exposed to a mixture of nitric oxides (NO -- 0.62 mg/m3, NO -- 0.60 mg/m3) and chlorine (1.02 mg/m3), for 12 weeks, a series of changes in peripheral blood have been found. In the erythrocytic system, a decrease in haemoglobin concentration in blood and mean haemoglobin concentration in erythrocytes, and increase in ALA-D dehydratase activity have been revealed. In the leukocytic system, lymphocytopenia has been found associated with a reduction in the number of lymphocytes, both beta-glucuronidase-positive and beta-glucuronidase-negative, as well as impaired lysosomes in lymphocytes, which is proved by a decrease in the number of lymphocytes with granular cytochemical reaction on beta-glucuronidase (BG) with a simultaneous increase in the number of lymphocytes with granular-diffusive and diffusive cytochemical reaction to BG. In neutrophils only a decrease in BG activity has been observed. The obtained results demonstrate that the mixture of nitric oxides and chlorine of a relatively low concentration exhibits toxic effects mainly on the lymphocytic and erythrocytic systems.
D000818:Animals; D002713:Chlorine / Q000633:toxicity*; D004563:Electrochemistry; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology; D005966:Glucuronidase / Q000097:blood; D006454:Hemoglobins / Q000378:metabolism; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects*; D008297:Male; D009569:Nitric Oxide / Q000633:toxicity*; D000623:Porphobilinogen Synthase / Q000097:blood; D051381:Rats
D006454:Hemoglobins; D009569:Nitric Oxide; D002713:Chlorine; D005966:Glucuronidase; D000623:Porphobilinogen Synthase
Chemiczne czynniki szkodliwe dla zdrowia wystepujace w obróbce elektrochemicznej: II. Badania doświadczalne nad toksycznościa tlenków azotu i chloru. Zmiany w krwi obwodowej u szczurów.