Generalization of drug-seeking behavior in dogs.
Drug-naive dogs which do not spontaneously initiate morphine self-administration were given one of three treatments and tested for subsequent morphine self-administration. Neither the dogs given the treatment of response-contingent drinking water nor those given d-amphetamine by passive infusions subsequently showed significant self-administration of morphine. However, the third group which self-administered d-amphetamine did subsequently self-administer morphine. The data suggest that self-administration of one reinforcing psychoactive drug may increase the probability of subsequently self-administering another.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology; D004285:Dogs; D009020:Morphine / Q000494:pharmacology*; D012054:Reinforcement, Psychology; D012646:Self Administration; D013997:Time Factors
D009020:Morphine; D003913:Dextroamphetamine