Electroencephalographic serotonin synchronization: area postrema and solitary tract nucleus.
Unilateral microinjection of serotonin (5-HT) into the solitary tract nucleus (STN) increased the amplitude of all electroencephalographic (EEG) waves ipsilateral to the site of injection. Unilateral STN blockage by lidocaine blocked the ipsilateral effect of 5-HT. Unilateral lesion of the area postrema (AP) increased the amplitude of the ipsilateral EEG in response to 5-HT stimulation of the obex. In contrast, unilateral lesion of both AP and STN decreased the amplitude of the ipsilateral EEG response to 5-HT. The data show that the STN is critically involved in 5-HT synchronizing mechanism and that the AP may have an inhibitory tonic effect on the STN.
D000818:Animals; D001933:Brain Stem / Q000187:drug effects / Q000502:physiology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D007839:Functional Laterality; D006168:Guinea Pigs; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D008845:Microinjections; D011903:Raphe Nuclei / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology*
D012701:Serotonin; D008012:Lidocaine