Vitamin A effects on hepatic Golgi apparatus architecture.
Effects of dietary vitamin A deficiency and excess on Golgi apparatus architecture were determined for livers of male CDF rats. In deficient animals, Golgi apparatus stacks were reduced in diameter and characterized by small, often highly fenestrated, saccules. Total membrane surface occupied by Golgi apparatus membranes also was less. Golgi apparatus of livers of animals receiving vitamin A in excess were more variable ranging from nearly normal appearance to much larger than normal. Saccules were larger and lacked the numerous fenestrations shown by Gol;gi apparatus of vitamin A deficient animals. Numbers and appearance of secretory vesicles and total number of small vesicular profiles were unaffected by vitamin A status of the animal. Unusual cisternal configurations were encountered much more frequent at the mature face of Golgi apparatus of animals fed vitamin A excess than in animals receiving adequate vitamin A and were absent from Golgi apparatus of animals receiving no vitamin A. Except for slightly swollen mitochondria and a loss of the "zone of exclusion" surrounding the nucleus, both observed in vitamin A excess, the Golgi apparatus response was the only ultrastructural alteration in liver that responded consistently to changes in vitamin A status.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D006056:Golgi Apparatus / Q000187:drug effects* / Q000648:ultrastructure; D007425:Intracellular Membranes / Q000648:ultrastructure; D008247:Lysosomes / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D014801:Vitamin A / Q000494:pharmacology*; D014802:Vitamin A Deficiency / Q000473:pathology
D014801:Vitamin A; D000135:Acid Phosphatase