[Radiological investigations of cobalamin supply with regard to folate status (author's transl)].
In a study with 307 volunteers we estimated the cobalamin status by radiochemical (plasma cobalamin) and haematological (lobe average of granulocytes) methods. As there is a close biochemical connection between the folate and cobalamin metabolism (methyl-tetrahydrofolate-trap hypothesis) we additionally determined the plasma- and erythrocyte folate levels in 307 volunteers by radioimmunoassay. Further metabolic studies in humans showed that a cobalamin concentration of less than 160 pg/ml indicates a deficient supply. In the present study 6% of the men and 8% of the women showed an inadequate alimentary supply.
D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005492:Folic Acid / Q000097:blood*; D005860:Germany, West; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D009504:Neutrophils; D011863:Radioimmunoassay; D012737:Sex Factors; D014805:Vitamin B 12 / Q000097:blood*; D014806:Vitamin B 12 Deficiency / Q000453:epidemiology
D005492:Folic Acid; D014805:Vitamin B 12
Radiologische Untersuchungen zum Cobalamin-Versorgungszustand unter vergleichender Berücksichtigung des Folatstatus.