Correlations between DNCB skin hypersensitivity and leukocyte migration inhibition by DNCB-coated human erythrocytes.
Correlations between skin hypersensitivity to DNCB and LMI in presence of lyophilized, DNCB-coated human erythrocytes were evaluated. False positive results were found in 2 out of 25 (8%) non-sensitized donors and false negative--in 5 out of 21 (24%) sensitized patients. In follow-up evaluation after topical DNCB sensitization significant MI was usually seen about 3 weeks after sensitization and only in a part of patients after 6-9 weeks. Time limitations in the application of LMI test for evaluation of effects of immunosuppressive treatment are discussed.
D002464:Cell Migration Inhibition; D003951:Diagnostic Errors; D004137:Dinitrochlorobenzene; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis*; D007111:Immunity, Cellular; D007962:Leukocytes / Q000276:immunology*; D009578:Nitrobenzenes; D012867:Skin / Q000276:immunology*
D004137:Dinitrochlorobenzene; D009578:Nitrobenzenes