Urinary tract carcinoma in patients with analgesic nephropathy.
In 19 patients with analgesic nephropathy followed at 6- to 8- month intervals during the past 8 years (average follow-up time 5.1 years), 2 patients developed cancer of the urinary tract. Both patients had heavy consumption of analgesic for more than 25 years, however, they had stopped its use 4 and 8 years ago, respectively. The incidence of bladder tumors in the province of New Brunswick is noted to be 28 per 100,000 population for 5 years. The occurrence of carcinoma in 2 patients in a group of 19 patients with analgesic abuse suggests an association.
D000368:Aged; D000700:Analgesics / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000150:complications; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
D000700:Analgesics