Chronic tetanus: clinical report and histochemistry of muscle.
A patient who was partially immune to tetanus developed nonfulminant tetanus after a minor injury. Manifestations of the disease persisted for over 17 months. Electrophysiologic studies revealed an absent silent period in the masseter muscle, large-amplitude F-responses, and denervation. A muscle biopsy showed neurogenic atrophy with reinnervation. This observation supports the existence of chronic tetanus and provides morphologic evidence for a peripheral action of tetanus toxin in humans.
D000328:Adult; D002908:Chronic Disease; D003975:Diazepam / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009121:Muscle Denervation; D009132:Muscles / Q000473:pathology* / Q000503:physiopathology; D013742:Tetanus / Q000188:drug therapy / Q000473:pathology*; D013744:Tetanus Toxin / Q000494:pharmacology
D013744:Tetanus Toxin; D003975:Diazepam