Antischistosomal effects of cyclosporin A.
Administration of cyclosporin A, a new selective immunosuppressive agent, to mice infected with Schistosoma mansoni resulted in a significant reduction in the number of mature and immature male and, to a greater extent, female worms. With lower, subeffective, doses a reduction in hemoglobinase activity and protein content of female schistosomes is produced. Evidence available so far suggests that the antischistosomal effects of cyclosporin A are mediated through a stimulation of host mechanisms directed against the parasite.
D000818:Animals; D003524:Cyclosporins / Q000494:pharmacology*; D004159:Diphenylamine / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D017879:Isothiocyanates; D051379:Mice; D012550:Schistosoma mansoni; D012556:Schistosomicides; D013861:Thiocyanates / Q000494:pharmacology; D013997:Time Factors
D003524:Cyclosporins; D017879:Isothiocyanates; D012556:Schistosomicides; D013861:Thiocyanates; D004159:Diphenylamine; C012391:amoscanate