Studies on neplanocin A, new antitumor antibiotic. I. Producing organism, isolation and characterization.
Neplanocin A. C11H13N5O3, is a novel carbocyclic analog of adenosine with cyclopentene. It was isolated from the culture filtrate of Ampullariella regularis A11079 by means of ion-exchange, carbon, silica gel adsorption, or partition chromatography. Neplanocin A forms crystals, and is stable at acidic or alkaline pH. Neplanocin A has cytotoxicity against L5178Y cells in culture and showed a remarkable effect on the life prolongation of mice infected with L1210 leukemia.
D000241:Adenosine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006999:Hypocreales / Q000145:classification / Q000378:metabolism*; D051379:Mice
D000903:Antibiotics, Antineoplastic; C031096:neplanocin A; D000241:Adenosine