Variation in nucleolar organizer activity in lymphocytes of females with adenocarcinoma.
With the use of Ag staining and conventional light microscopy, a difference is visualized in the frequency of nucleolar organizer regions between PHA-stimulated lymphocytes from normal females and females with various types of adenocarcinoma. This difference in NOR activity is more pronounced in G chromosome than D chromosomes. It is feasible that rDNA gene activity in PHA-stimulated lymphocytes is augmented in patients with adenocarcinoma due to the presence of plasma mediators arising from cellular malignancies. The NOR regions located on G chromosomes are considered to be more sensitive to these mediators than those on D chromosomes.
D000230:Adenocarcinoma / Q000235:genetics*; D000328:Adult; D000368:Aged; D002901:Chromosomes, Human, 13-15; D002904:Chromosomes, Human, 21-22 and Y; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008875:Middle Aged; D009697:Nucleolus Organizer Region / Q000473:pathology*; D012269:Ribosomal Proteins / Q000235:genetics; D012834:Silver
D012269:Ribosomal Proteins; D012834:Silver