Failure to detect soluble tumor associated antigen by radioimmunoassay in bovine lymphoma.
The detection of circulating soluble tumor-associated antigen by radioimmunoassay was attempted in cows with lymphoma. The assay system did detect PAGE-purified tumor-associated antigen but did not detect immunoreactive substances in the sera of 20 affected animals and 20 normal cattle. Similarly, ultrafiltration of low pH-dissociated serum to separate immune complexes did not aid in the detection of antigen.
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis*; D002417:Cattle / Q000276:immunology; D002418:Cattle Diseases / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology / Q000662:veterinary*; D011863:Radioimmunoassay / Q000662:veterinary*
D000951:Antigens, Neoplasm