Preparation and biological activity of some 2-substituted 3-(4'carboxyphenyl)-7-nitro-4 (3H)-quinazolinones.
2-Methyl-7-nitro-3,1-(4H)-benzoxazin-4-one (4) (1) has been treated with various carboalkoxy anilines to furnish 2-methyl-3-(4'carboalkoxyphenyl)-7-nitro-4 (3H)-quinazolinones (1-3). Condensation of 1-3 with aromatic aldehydes yielded 2-styryl-3-(4'carboalkoxyphenyl)7-nitro-4 (3H)-quinazolinones (4-21 except 6). Comp. 17 was the most active one against B. subtilis and S. aurens.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects*; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D011799:Quinazolines