[Effects of a tryptophan load on brain levels of serotonin in normal and diabetic rats].
The changes of brain tryptophan and 5-HT levels have been explored in the diabetic rat during the first hour after an intraperitoneal load of tryptophan. The obtained data confirm that diabetes decreases the basal levels of tryptophan but not those of 5-HT. Also, it has been shown that diabetes remarkably depresses the rate of the aminoacid accumulation and almost completely inhibits the rise of 5-HT after the tryptophan load.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D008297:Male; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D014364:Tryptophan / Q000494:pharmacology*
D012701:Serotonin; D014364:Tryptophan
Effetti di un carico di triptofano sui livelli cerebrali di serotonina in ratti normali e diabetici.