[Comparative study of femoral vasodilatator effects of naftidrofuryl and nicergoline on dog (author's transl)].
This study investigates in anaesthetized dogs kinetics and efficiency of peripheral vasodilator effects of naftidrofuryl and nicergoline after intraarterial and intramuscular administration and also their possible action on arterial blood pressure. The study of kinetics of vasodilator effects of naftidrofuryl and nicergoline by the intraarterial route at doses equal or according to the doses used in clinical practice on the one hand and the study of the dose-vasodilatation and dose-hypotension regressions for doses of 0.025-0.050-0.100 mg/kg on the other hand show that: 1. naftidrofuryl has a good dilator effect, stronger and a little shorter than that of nicergoline. 2. nicergoline produces a dose-related decrease in arterial pressure whereas naftidrofuryl does not alter it. The results obtained by the intramuscular administration show that: 3. naftidrofuryl, at 2-4-8 mg/kg, has a strong and lasting vasodilator effect, proportional to doses, without alteration of the arterial pressure. 4. nicergoline, at 0.25-1-4 mg/kg, is very hypotensive and its vasodilator effect observed by the intraarterial route is not confirmed.
D000818:Animals; D001794:Blood Pressure; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004873:Ergolines / Q000494:pharmacology*; D005260:Female; D005263:Femoral Artery / Q000187:drug effects; D005663:Furans / Q000494:pharmacology*; D007269:Injections, Intra-Arterial; D007273:Injections, Intramuscular; D007700:Kinetics; D008297:Male; D009257:Nafronyl / Q000494:pharmacology*; D009530:Nicergoline / Q000494:pharmacology*; D013997:Time Factors; D014665:Vasodilator Agents
D004873:Ergolines; D005663:Furans; D014665:Vasodilator Agents; D009257:Nafronyl; D009530:Nicergoline
Etude comparative des effets vasodilatateurs fémoraux du naftidrofuril et de la nicergoline chez lé chien.