Chelation in metal intoxication XI: effect of thiol chelators on lead poisoned rabbits.
Potentials of 2,3 Dimercapto succinic acid (DMS) and D-Penicillamine, the currently acclaimed heavy metal chelating drugs, to enhance urinary excretion of lead and restore altered levels of urinary delta-amino-levulinic acid (delta-ALA) and blood lead, -zinc-protoporphyrin (ZPP) -delta-aminolevulinic acid dehydratase (delta-ALA-D) in lead poisoned rabbits, were compared. The better performance of DMS than D-Penicillamine has been attributed to two -SH groups as a stronger metal binding site in DMS molecule.
D000622:Aminolevulinic Acid / Q000652:urine; D000818:Animals; D002614:Chelating Agents / Q000627:therapeutic use*; D007854:Lead / Q000097:blood; D007855:Lead Poisoning / Q000188:drug therapy*; D008297:Male; D011524:Protoporphyrins / Q000378:metabolism; D011817:Rabbits; D013438:Sulfhydryl Compounds / Q000627:therapeutic use*
D002614:Chelating Agents; D011524:Protoporphyrins; D013438:Sulfhydryl Compounds; D007854:Lead; D000622:Aminolevulinic Acid