Acute glomerular lesions induced by polyvinyl alcohol-bovine serum albumin (PVA-BSA) complex in the rat--a possible mechanism of local immune complex formation.
Two types of renal lesions, renal cortical necrosis and acute proliferative glomerular lesions were induced by a single or several intravenous injections of polyvinyl alcohol (PVA)-bovine serum albumin (BSA) complex in Wistar King Aptakeman rats. All animals given a single dose died of renal cortical necrosis within 7 days. Injected PVA-BSA complex was localized in the glomerular capillary lumina in a pattern of thrombosis. All animals given daily injections of a small dose for 5 days developed acute proliferative glomerular lesions accompanied by a significant deposition of IgG, IgM and C3 in the mesangium in which the PVA-BSA complex had been localized. The subsequent deposition of immunoglobulins and complement was suggestive of a possible mechanism of local immune complex formation in the development of the present proliferative glomerular lesions.
D000208:Acute Disease; D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis*; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology*; D007668:Kidney / Q000473:pathology; D007678:Kidney Glomerulus / Q000276:immunology; D008297:Male; D010974:Platelet Aggregation; D011142:Polyvinyl Alcohol / Q000276:immunology*; D011507:Proteinuria / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D012710:Serum Albumin, Bovine / Q000276:immunology*
D000936:Antigen-Antibody Complex; D012710:Serum Albumin, Bovine; D011142:Polyvinyl Alcohol