Dynamics of myocardial contrast enhancement: an in vivo computed-tomographic study.
Enhancement of normal functioning myocardium was quantitated in 15 dogs by serial computed transmission tomographic (CT) images during the bolus (10 ml/sec.) or slow (1 ml/sec.) intravenous injection of diatrizoate contrast media (1 ml/kg body weight) in concentrations of 37, 18.5, or 9.25 g iodine (I)/dl. Homogenous images of myocardial enhancement were obtained. However, major streak artifacts were observed frequently when contrast material was injected as a bolus, and myocardial edges were not defined clearly when contrast material with a concentration of 9.25 g I/dl was injected slowly. Time-attenuation curves of normal myocardial enhancement constructed from serial CT images demonstrated a peak in contrast enhancement (delta Hounsfield units, 22-45) followed by a period of deterioration that lasted two to three minutes. These results can be applied to make optimal use of both single (static) and serial (dynamic) myocardial CT images.
D000818:Animals; D003973:Diatrizoate / Q000008:administration & dosage; D004285:Dogs; D006321:Heart / Q000000981:diagnostic imaging* / Q000502:physiology; D007275:Injections, Intravenous; D011856:Radiographic Image Enhancement; D014057:Tomography, X-Ray Computed
D003973:Diatrizoate