Changes in gastric parietal cells during prolonged intermittent corticosteroid treatment.
Immature A/J mice were treated for up to 7 weeks with intermittent doses of triamcinolone hexacetonide and were thereafter allowed to recover for 7 weeks. Structural examinations and morphological measurements were performed on the parietal cells in the gastric mucosa. By the 3rd injection a significant decrease was noted in the number of the above cells - a feature that lasted throughout the experimental period. In contrast, the diameter of the parietal cells increased. However, following recovery, the latter returned to their normal size.
D000818:Animals; D002452:Cell Count; D005753:Gastric Mucosa / Q000166:cytology* / Q000187:drug effects; D007700:Kinetics; D051379:Mice; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D014222:Triamcinolone Acetonide; C005900:triamcinolone hexacetonide