Cytopathological effect of partial cystectomy of rats.
The effect of partial cystectomy on induction of DNA synthesis in the urinary bladder epithelium was studied in a total of 147 male F344 rats. DNA synthesis started 12 hours after 75% or 50% resection of the bladder, and reached a maximum at 48 hours with a mean labelling index of 15.8% after 75% partial cystectomy and 13.8% after 50% partial cystectomy. In these two groups the proliferative activity of bladder epithelial cells returned to normal after 2 weeks and 1 week, respectively. Cytodifferentiation of epithelial cells, observed by transmission and scanning electron microscopy, remained normal during the regeneration process.
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D004247:DNA / Q000096:biosynthesis*; D004848:Epithelium / Q000648:ultrastructure; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D001743:Urinary Bladder / Q000166:cytology / Q000378:metabolism / Q000601:surgery*
D004247:DNA