[Role of the adrenals in the detoxication of dioxidine].
An original antibacterial drug dioxidine was subjected to toxicological studies during long-term parenteral administration of 0.5% solution to rats and guinea-pigs (in doses of 25-100 mg/kg). It was found that susceptibility to the drug correlated well with adrenal function. Guinea-pigs were more susceptible to dioxidine than rats. The data obtained indicate the existence of the interplay between non-specific resistance to toxic agents and glucocorticoid potency.
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D006168:Guinea Pigs; D008658:Inactivation, Metabolic; D009929:Organ Size / Q000187:drug effects; D011810:Quinoxalines / Q000378:metabolism / Q000633:toxicity*; D051381:Rats
D000890:Anti-Infective Agents; D011810:Quinoxalines; C001077:dioxidine
Rol' nadpochechnikov v detoksikatsii dioksidina.