[Mechanisms of action of nonachlazine].
In animals with a ligated anterior descending left coronary artery, a single administration of nonaclazine (5 mg/kg bw) leads to a marked increase in the coronary blood flow and to an improvement in cardiovascular system function. Administration of nonachlazin for 7 days helps normalize the electrophysiological and hemodynamic characteristics and produces a beneficial effect on the myocardial blood flow and contractility. Interaction of nonaclazine with adrenergic receptors does not appear to have any decisive significance in the drug action mode.
D000818:Animals; D002682:Chinchilla; D003326:Coronary Circulation / Q000187:drug effects; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D009124:Muscle Proteins / Q000378:metabolism; D009200:Myocardial Contraction / Q000187:drug effects; D009203:Myocardial Infarction / Q000188:drug therapy*; D009628:Nonachlazine / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D010640:Phenothiazines / Q000494:pharmacology*; D011817:Rabbits
D009124:Muscle Proteins; D010640:Phenothiazines; D009628:Nonachlazine
O nekotorykh mekhanizmakh deĭstviia nonakhlazina.