Tissue magnesium status in diabetes mellitus.
Leucocyte and erythrocyte magnesium was assayed in 17 healthy subjects and 17 insulin dependent diabetic patients. Plasma magnesium concentration (mean +/- standard error of mean) was significantly lower in the diabetic patients (0.80 +/- 0.02 mmol/l), compared with the healthy subjects (0.90 +/- 0.02 mmol/l, p less than 0.001), but the leucocyte and erythrocyte magnesium content was not significantly different in the diabetic patients (34.5 +/- 0.8 and 6.2 +/- 0.2 mmol/kg dry solids) compared with the healthy subjects (35.5 +/- 0.8 and 6.5 +/- 0.11 mmol/kg dry solids). In a separate study skeletal muscle obtained by needle biopsy was also assayed. Plasma magnesium in 10 diabetic patients (0.74 +/- 0.01 mmol/l) was significantly lower than in 16 healthy subjects (0.85 +/- 0.02 mmol/l, p less than 0.001), but there was no significant difference in the mean muscle magnesium content (43.0 +/- 0.7 compared with 40.7 +/- 0.9 mmol/kg dry solids in the diabetic patients).
D000293:Adolescent; D000328:Adult; D000368:Aged; D003920:Diabetes Mellitus / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism; D004912:Erythrocytes / Q000032:analysis*; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000032:analysis*; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000032:analysis; D011188:Potassium / Q000032:analysis; D012016:Reference Values; D012964:Sodium / Q000032:analysis
D012964:Sodium; D008274:Magnesium; D011188:Potassium