Follicular thyroid carcinoma: response to chemotherapy.
A 69-year-old woman with far advanced inoperable follicular carcinoma of the thyroid became refractory to radioactive iodine therapy and to combination chemotherapy with adriamycin and cyclophosphamide. She then attained a good clinical response to chemotherapy with adriamycin, CCNU and methotrexate (ACMe); this lasted more than a year. The regimen of adriamycin, CCNU, and methotrexate deserves further study for patients with follicular thyroid carcinoma.
D000368:Aged; D002277:Carcinoma / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008130:Lomustine / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D013964:Thyroid Neoplasms / Q000188:drug therapy*
D008130:Lomustine; D004317:Doxorubicin; D003520:Cyclophosphamide; D008727:Methotrexate