Rapid effects of acrylamide on spiroperidol and serotonin binding in neural tissue.
The effects of in vivo exposure to acrylamide on 3H-spiroperidol binding to striatal and (3)5-HT binding to forebrain membranes were investigated. Rats were gavaged with 100 mg/kg acrylamide and sacrificed at various times thereafter. Rapid changes were seen with specific binding of spiroperidol increasing by 1/2 hour and 5-HT binding by 2 hours after acrylamide treatment. Although the overall effect of acrylamide was to elevate binding for at least 24 hours, binding of spiroperidol may have exhibited a biphasic profile. The possibility of dual time-dependent mechanisms involved in the effects of acrylamide is discussed.
D020106:Acrylamide; D000178:Acrylamides / Q000494:pharmacology*; D000818:Animals; D002090:Butyrophenones / Q000378:metabolism*; D008297:Male; D008566:Membranes / Q000378:metabolism; D009417:Nerve Tissue / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism*; D013997:Time Factors
D000178:Acrylamides; D002090:Butyrophenones; D020106:Acrylamide; D012701:Serotonin; D013134:Spiperone