Rationale for prophylactic antibiotics and neurosurgery.
A program of antimicrobial prophylaxis for neurosurgical patients was implemented at three community hospitals after review of the previously recorded cases of postoperative sepsis and the antibiotic sensitivity of the prevailing pathogen, Staphylococcus. No primary wound infections occurred  in a series of 1000 consecutive operations. The rational basis for prophylactic antibiotics is discussed.
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001414:Bacitracin / Q000627:therapeutic use; D002512:Cephalothin / Q000627:therapeutic use; D004917:Erythromycin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008712:Methicillin / Q000627:therapeutic use; D008875:Middle Aged; D009493:Neurosurgery; D010068:Oxacillin / Q000627:therapeutic use; D011292:Premedication; D013203:Staphylococcal Infections / Q000517:prevention & control*; D013530:Surgical Wound Infection / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D001414:Bacitracin; D004917:Erythromycin; D008712:Methicillin; D002512:Cephalothin; D010068:Oxacillin