[Comparative characteristics of the immunotropic activity of sodium diclofenac, indomethacin and sodium salicylate].
It has been shown in experiments on mice that sodium diclofenac and indomethacin inhibited antibody titers and the number of rosette-forming cells (RFC) in mice immunized with sheep red blood cells. Sodium salicylate in all test doses did not produce any shifts in rosette-formation but lowered the number of RFC. As regards the immunodepressant activity, sodium diclofenac compares very favourably with indomethacin and sodium salicylate. Enhancement of the immunoreactivity inhibition caused by the drugs was not proportional to the increase in their antiphlogistic effects determined by the Selye model of inflammation.
D000818:Animals; D000893:Anti-Inflammatory Agents; D000917:Antibody Formation / Q000187:drug effects; D004008:Diclofenac / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D007114:Immunization; D007166:Immunosuppressive Agents; D007213:Indomethacin / Q000276:immunology*; D008297:Male; D051379:Mice; D010648:Phenylacetates / Q000276:immunology*; D012397:Rosette Formation; D012980:Sodium Salicylate / Q000276:immunology*
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D010648:Phenylacetates; D004008:Diclofenac; D012980:Sodium Salicylate; D007213:Indomethacin
Sravnitel'naia kharakteristika immunotropnoi aktivnosti natriia diklofenaka, indometatsina i natriia salitsilata.