Selective, immunologically nonspecific adherence of lymphoid and myeloid cells to Leydig cells.
In mixed lymphocyte-testis cell cultures, lymphoid cells form rosettes around a testis cell population. The rosette formation seems to reflect cell type specific, but not immune recognition, because: a) rosettes are formed only around Leydig, But not around other testis cells; b) most, if not all normal lymphoid cells can be bound by Leydig cells; c) in addition, Leydig cells bind presumably monoclonal lymphoid and myeloid tumor line cells, but no other cell types.
D000818:Animals; D002448:Cell Adhesion; D002460:Cell Line; D002999:Clone Cells / Q000166:cytology; D007985:Leydig Cells / Q000166:cytology*; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000473:pathology; D012397:Rosette Formation; D013737:Testis / Q000166:cytology