[Effect of phenazepam and barbamyl on normalization of the sulfhydryl group content of brain tissue following sleep deprivation].
Rats placed into the rotating cylindrical tretbahn (diameter 50 cm, 2.3 r. p. m.) for 24, 48 and 96 hrs developed the sleep deprivation resulting in elevation of SH-group level for over 20% in mesencephalon and diencephalon. The normalizing occurred within 48 hrs. The high level of brain SH-groups in 24-hr sleep-deprived rats changed insignificantly after 12 hrs of resting. The intraperitoneal administration of phenazepam (1 mg/kg) or barbamyl (70 mg/kg) had no effect whereas their combination normalized the SH-groups level within 12 hrs of rest.
D000654:Amobarbital / Q000494:pharmacology*; D000818:Animals; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects*; D001933:Brain Stem / Q000032:analysis; D006624:Hippocampus / Q000032:analysis; D008297:Male; D009044:Motor Cortex / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012892:Sleep Deprivation; D013438:Sulfhydryl Compounds / Q000032:analysis*; D014793:Visual Cortex / Q000032:analysis
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D013438:Sulfhydryl Compounds; D001569:Benzodiazepines; C017928:phenazepam; D000654:Amobarbital
Vliianie fenazepama i barbamila na normalizatsiiu soderzhaniia sul'fgidril'nykh grupp v tkani mozga krys posle lisheniia sna.