Radioprotective effect of MPG (2-mercaptopropionylglycine) on the postnatal growth of mice irradiated in utero.
Pregnant mice at gestation days 14 1/4, 16 1/4 and 18 1/4 were exposed to 250 R gamma rays in presence and absence of MPG, a -SH radioprotector. There was a biphasic weight loss in post partum animals born to irradiated mothers. In the MPG treated young ones, the second weight loss was remarkably averted. It was also found that 14 1/4 day of gestation was more radiosensitive than 16 1/4 or 18 1/4 days.
D000603:Amino Acids, Sulfur / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight; D005260:Female; D006128:Growth / Q000528:radiation effects*; D051379:Mice; D011247:Pregnancy; D011837:Radiation-Protective Agents / Q000494:pharmacology; D013997:Time Factors; D008625:Tiopronin / Q000494:pharmacology*
D000603:Amino Acids, Sulfur; D011837:Radiation-Protective Agents; D008625:Tiopronin