[On the influence of D-penicillamine on collage metabolism - investigations of the rupture of strength in tailfibre in rats of several ages (author's transl)].
The tensile strength of rat tail tendons of animals wtih a different age is more influenced by D-Penicillamine (DPA) in younger rats than in elderly rats. DPA has the best effect in the regions with the highest collagen turnover. After the use of DPA the collagen of tails of the elderly rats resembles the collagen of the younger animals. The reason of this alteration is probably a lower degree of cross-links of the collagen after the use of DPA.
D000375:Aging; D000818:Animals; D003094:Collagen / Q000378:metabolism*; D008954:Models, Biological; D010396:Penicillamine / Q000494:pharmacology*; D051381:Rats; D013623:Tail; D013710:Tendons / Q000187:drug effects; D013718:Tensile Strength / Q000187:drug effects
D003094:Collagen; D010396:Penicillamine
Zum Einfluss von D-Penicillamin auf der Kollagenstoffwechsel - Reissfestikeitsuntersuchungen an Schwanzsehnen verschieden alter Ratten.