Cytotoxicity and mutagenicity of the fungicides captan and folpet in cultured mammalian cells CHO/HGPRT system).
The cytotoxicity and mutagenicity of the fungicides captan and folpet were determined in the CHO/HGPRT system which utilizes Chinese hamster ovary cells and resistance to 6-thioguanine to estimate mutation induction at the hypoxanthine-guanine phosphoribosyl transferase locus. Treatment of cultures with each compound for 5 hr is serum-free medium resulted in reproducible, significant, concentration-dependent increase in the frequency of 6-thioguanine-resistant mutants.
D000818:Animals; D002215:Captan / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D006224:Cricetinae; D005260:Female; D005659:Fungicides, Industrial / Q000633:toxicity*; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D009153:Mutagens; D010797:Phthalimides / Q000633:toxicity*
D005659:Fungicides, Industrial; D009153:Mutagens; D010797:Phthalimides; D007041:Hypoxanthine Phosphoribosyltransferase; D002215:Captan; C005020:folpet