Sustained electrical stimulation of the perforant path duplicates kainate-induced electrophysiological effects and hippocampal damage in rats.
Electrical stimulation of the perforant path of urethane-anesthetized rats for 24 h evoked hippocampal granule cell population spikes, epileptiform discharges, and abolished the recurrent inhibition of granule cells (as determined with the twin pulse technique). After 24 h of stimulation, hilar interneurons of area dentata and the regions of the CA3 pyramidal cells which receive granule cell input were damaged; 'CA2' pyramidal cells and dentate granule cells were relatively unaffected. Pericellular spaces possibly indicative of acute gliotoxicity were observed in the CA1 pyramidal cell body region. These results establish a causative relationship between excessive presynaptic neuronal activity and postsynaptic neuronal damage.
D000818:Animals; D004553:Electric Conductivity; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011759:Pyrrolidines; D007608:Kainic Acid