[Lipid composition and activity of certain enzymes in membranes of intestinal epithelium microvilli in rats with experimental hypercholesterinemia].
It is established that in membranes of small intestine epithelial cells microvilli in rats, which were administered cholesterol for a long time, the content of this sterol and its esters as well as of phospholipids is different. Differences in the content of lipids are a reason of changes in the sucrose, alkaline phosphatase and leucilamino-peptidase activities. These changes are accompanied by an increase on the molar cholesterol esters-free cholesterol ratio in blood plasma and cholesterol-phospholipids ratio in the microvilli membranes. Beta-sitosterol administered to experimental animals incorporates into the intestine plasma membranes, blocks up the transfer sites, inhibiting cholesterol absorption, which evidently decreases the sterol content in blood serum.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D002791:Cholesterol, Dietary; D004195:Disease Models, Animal; D004848:Epithelium / Q000378:metabolism; D006937:Hypercholesterolemia / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism*; D007931:Leucyl Aminopeptidase / Q000378:metabolism; D050356:Lipid Metabolism; D008871:Microvilli / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D013261:Sterols / Q000378:metabolism; D013395:Sucrose / Q000378:metabolism
D002791:Cholesterol, Dietary; D010743:Phospholipids; D013261:Sterols; D013395:Sucrose; D002784:Cholesterol; D000469:Alkaline Phosphatase; D007931:Leucyl Aminopeptidase
Lipidnyĭ sostav i aktivnost' nekotorykh fermentov membram mikrovorsinok kishechnogo épiteliia krys pri éksperimental'noĭ giperkholesterinemii.