A hospital-based survey of radiological sacroiliitis and HLA-B27 and Cw2 in Navajo and Hopi Indians.
The frequency of radiological sacroiliitis and its association with HLA-B27, Cw1, and Cw2 were determined in Navajo and Hopi Indians coming to a community hospital. In the Navajo, the phenotype frequency of HLA-B27 was 36% and the frequency of sacroiliitis, 11%. In contrast, among the Hopi, the phenotype frequency of HLA-B27 was 9% and the frequency of sacroiliitis, 4%. Of the Navajo men, who had sacroiliitis and were HLA typed, 83% were HLA-B27 positive. The increased frequency of radiological sacroiliitis and were HLA typed, 83% were HLA-B27 positive. The increased frequency of radiological sacroiliitis in the Navajo was felt to be related to the high frequency of HLA-B27 and Reiter's syndrome in this population. HLA-B27, HLA-Cw1, and HLA-Cw2 are known to be in linkage disequilibrium, and about one-half of the men with sacroiliitis from both tribes had concurrence of HLA-B27 and HLA-Cw2.
D001130:Arizona; D016918:Arthritis, Reactive / Q000276:immunology; D004405:Dysentery, Bacillary / Q000150:complications; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D006764:Hospitals, Community; D006801:Humans; D007198:Indians, North American; D007249:Inflammation / Q000000981:diagnostic imaging / Q000209:etiology; D007592:Joint Diseases / Q000276:immunology; D008297:Male; D010641:Phenotype; D011859:Radiography; D012446:Sacroiliac Joint / Q000000981:diagnostic imaging*; D013167:Spondylitis, Ankylosing / Q000276:immunology
D006680:HLA Antigens