[Activity of repeated administration of enilconazole (R 23 979) against Trichophyton verrucosum in cattle. A clinical trial (author's transl)].
234 Animals from twenty-eight different herds showed typical dermatophytic lesions which, after direct examination and culture, were found to be caused by T. verrucosum. The animals were subdivided into two groups of 165 (A) and sixty-nine (B) animals. These were treated with enilconazole (R 23 979) base, 10 per cent E.C., diluted in 50 parts of water to produce a 2,000 ppm spray. The dose administered varied from 0.5 litre in calves to 1 litre in adult cattle. Group A was treated four times with a spray at weekly intervals. Initially, group B was treated manually with a sponge as well as with the 2,000 ppm spray, then three times only with the spray. Treatment in group B was carried out at 3-4 day intervals and the total period of treatment was two weeks. A stereotype positive evolution of the lesions was observed in the majority of cases, resulting in stabilization of the lesions, improvement and, finally, the start of new hair growth. Two weeks after completion of treatment, recovery rates of 92 and 87 per cent were recorded in groups A and B respectively. Within five weeks, recovery rates were 93 and 88 per cent.
D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D005500:Follow-Up Studies; D007093:Imidazoles / Q000008:administration & dosage*; D014005:Tinea / Q000188:drug therapy / Q000662:veterinary*
D000935:Antifungal Agents; D007093:Imidazoles; C017435:enilconazole
Activiteit van herhaaldelijk toegediende enilconazole (R 23 979) tegen Trichophyton verrucosum bij runderen. Een klinische proef.