[Cellular immunity indices in rectal cancer under surgical and combined treatment].
The dynamics of cell-mediated immunity indices in 83 patients with rectal tumors who underwent surgery or received combined treatment (preoperative radiation + surgery) was followed. Cellular immunity was assessed on the basis of PHA-induced blastogenic reaction of lymphocytes (BRL) and spontaneous rosette-formation. In rectal tumor patients, particularly at stage IV, the level of PHA-induced BRL and the total number of rosette-forming cells (RFC) were lower than in healthy donors. Surgery did not produce any significant changes in cell-mediated immunity parameters: level of PHA-induced BRL decreased by 16,7%, while total RFC number increased by 17.2% in (mostly low-affinity forms). Preoperative radiation resulted in a significant decrease in lymphocyte ability to undergo PHA-induced blast-transformation (45%) and spontaneous rosette formation, high-affinity lymphocytes being most sensitive to ionizing radiation. Their fraction decreased by half.
D000328:Adult; D000368:Aged; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011300:Preoperative Care; D011879:Radiotherapy Dosage; D012004:Rectal Neoplasms / Q000276:immunology* / Q000628:therapy; D012397:Rosette Formation
Pokazateli kletochnogo immuniteta u bol'nykh rakom priamoĭ kishki pri khirurgicheskom i kombinirovannom lechenii.