Pulsatile venous flow in extracorporeal circulation.
Effects of pulsatile venous flow upon the microcirculation were investigated in conditions with different venous pressures by using regional perfusion in dog's hind legs. In animals with venous pressure of -18 cmH2O (Collapsed stage), venous pulsation brought about a significant increase in mean oxygen consumption ratio and suppressed a rise of mean resistance ratio significantly. In animals with venous pressure of +2 cmH2O (normal venous pressure stage), the venous pulsation was effective in a rise of mean oxygen consumption ratio but was not effective in suppression of mean resistance ratio. In animals with venous pressure of +10 cmH2O (congestive stage), no effect of venous pulsation was recognized. We suppose that the intermittent elevation of venous pressure by venous pulsation is effective for opening some capillaries in animals with venous pressure below +2 cmH2O.
D000818:Animals; D004285:Dogs; D005112:Extracorporeal Circulation / Q000379:methods; D066298:In Vitro Techniques; D008833:Microcirculation; D010101:Oxygen Consumption; D011674:Pulse; D014655:Vascular Resistance; D014680:Veins / Q000502:physiology*; D014690:Venous Pressure