Presence of multipotential hemopoietic cells in teratocarcinoma cultures.
Previous investigations have shown that the teratocarcinoma line PCC3/A/1 is able to differentiate in vitro to produce red blood cells of the primitive hemopoietic cell population of the mouse embryo. The present paper demonstrates the presence in the same cultures of multipotential cells capable of giving rise to colonies containing erythrocytes, macrophages, and megakaryocytes when stimulated by pokeweed-mitogen spleen-cell conditioned medium.
D000818:Animals; D002454:Cell Differentiation; D002460:Cell Line; D002478:Cells, Cultured; D004900:Erythroblasts / Q000473:pathology; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D008533:Megakaryocytes / Q000473:pathology; D051379:Mice; D008854:Microscopy, Electron; D013724:Teratoma / Q000196:embryology* / Q000648:ultrastructure