Biochemical effects of some organophosphorus insecticide on new targets in white rats.
The three S-n-propyl phosphates and phosphothioates: RH 218, profenofos and prothiophos were compared with fenitrothion in their potential as inhibitors of rat liver and brain AChE. Fenitrothion was more potent as an inhibitor than the three S-n-propyl derivatives. Incubation of hepatic protein enhanced ChE inhibition in brain in the case of fenitrothion, while it reduced the inhibitory effect of the S-n-propyl derivatives. On the other hand, the four organophosphorus esters caused hypoglycemia in both male and female rats and also reduced their blood urea with different degrees.
D000818:Animals; D001806:Blood Urea Nitrogen; D001921:Brain / Q000201:enzymology; D002800:Cholinesterase Inhibitors; D005260:Female; D005278:Fenitrothion / Q000633:toxicity*; D007003:Hypoglycemia / Q000139:chemically induced; D008099:Liver / Q000201:enzymology; D008297:Male; D063086:Organothiophosphates / Q000633:toxicity*; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D051381:Rats; D013329:Structure-Activity Relationship; D013347:Subcellular Fractions / Q000201:enzymology
D002800:Cholinesterase Inhibitors; D063086:Organothiophosphates; D009946:Organothiophosphorus Compounds; C032071:RH 218; C024273:profenofos; C032072:prothiophos; D005278:Fenitrothion