[Pruritus and bile acids. Determination of sulfalithoglycocholate and glycocholate in suction blister fluid and in serum (author's transl)].
Until now is not clear, whether bile acids play a role in hepatogenic pruritus in patients with cholestasis. A correlation between serum levels and itching does not exist, and therefore an accumulation of bile acids in the skin was made responsible for the etiology of pruritus. However, this could not be proved in skin homogenisates whereas bile acids were found accumulated in the surface lipids of the skin. For this reason, the investigations presented here deal with the determination of glycocholate and sulfalithoglycocholate in suction blister fluid and in serum. The levels of these bile acids were remarkably lower in the fluid of the subepidermally located blisters than in the serum. No significant difference was found between the group of patients with pruritus and cholestasis and the group without cholestasis. These results show that an accumulation of bile acids in the skin does not exist. A correlation between bile acids in the skin and pruritus cannot be proved.
D000328:Adult; D000368:Aged; D001647:Bile Acids and Salts / Q000032:analysis* / Q000097:blood; D001768:Blister / Q000378:metabolism*; D002779:Cholestasis / Q000150:complications; D005122:Exudates and Transudates / Q000032:analysis; D005260:Female; D006000:Glycocholic Acid / Q000031:analogs & derivatives* / Q000032:analysis* / Q000097:blood / Q000378:metabolism; D006801:Humans; D008095:Lithocholic Acid / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011537:Pruritus / Q000097:blood / Q000150:complications / Q000378:metabolism*
D001647:Bile Acids and Salts; C018154:sulfolithocholylglycine; D008095:Lithocholic Acid; D006000:Glycocholic Acid
Pruritus und Gallensäuren. Bestimmung von Sulfalithocholylglycin und Cholylglycin in der Saugblasenflüssigkeit und im Serum.