Alteration of the mutagenicity of human fecal extracts by hepatic microsomal enzymes.
Human fecal extracts obtain substances mutagenic to Salmonella typhimurium TA 100. The mutagenicity of these extracts can be reduced enzymatically by inducible mammalian microsomal enzymes. Liver homogenates from rats administered the polychlorinated biphenyl mixture of Aroclor 1254 and corn oil were both effective, relative to the quantity of microsomal protein available in the enzyme preparation.
D000328:Adult; D000818:Animals; D001140:Aroclors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction; D005243:Feces / Q000032:analysis*; D005260:Female; D006801:Humans; D008658:Inactivation, Metabolic; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D008875:Middle Aged; D009153:Mutagens / Q000378:metabolism*; D051381:Rats
D001140:Aroclors; D009153:Mutagens