Evaluation of medigoxin in outpatients.
We compared our ability to predict the dose of medigoxin and of digoxin required to achieve a fixed serum concentration (the dose requirement) in 33 outpatients. Preliminary work supported the assumptions that the steady state glycoside concentration achieved was proportional to the daily dose given to an individual, and that the bioavailability of the different tablet presentations was similar for either glycoside. We were not able to predict the dose requirement from patient characteristics with any more certainty for medigoxin than for digoxin. Not only the between-patient variability in dose requirement, but also the within-patient variability, was similar for the two glycosides. However the digoxin used had a dissolution rate of over 90% in 1 h. When comparing medigoxin with digoxin of lower, or more variable dissolution rate, medigoxin may be preferable.
D000704:Analysis of Variance; D002301:Cardiac Glycosides / Q000097:blood; D004077:Digoxin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008520:Medigoxin / Q000008:administration & dosage* / Q000378:metabolism; D011786:Quality Control; D012995:Solubility; D013607:Tablets
D002301:Cardiac Glycosides; D013607:Tablets; D004077:Digoxin; D008520:Medigoxin