[Phospholipase A2 localization in mitochondria].
The activation of mitochondrial phospholipase A2 by Ca2+ and Sr2+ has been studied. It was shown that complete inactivation of the enzyme occurs after treatment of isolated mitochondria with ruthenium red, inhibitor of Ca transport across the inner mitochondrial membrane. It was concluded that phospholipase A2 is localized on the inner mitochondrial membrane and that its activity is stimulated by Ca2+ on the side of the mitochondrial matrix.
D000818:Animals; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology; D004789:Enzyme Activation; D007425:Intracellular Membranes / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000201:enzymology*; D010740:Phospholipases / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D051381:Rats; D013324:Strontium / Q000494:pharmacology
D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2; D002118:Calcium; D013324:Strontium
Issledovanie lokalizatsii fosfolipazy A2 v mitokhondriiakh.