[Exclusion of propyl alcohol from the medium for culturing the erythromycin producer].
Propyl alcohol is a precursor of erythromycin. It is one of the components of the medium for production of the antibiotic. Still, this raw material has an unfavorable effect on employees and is fire hazardous. The results of the development of the erythromycin-producing organism are presented. A strain requiring no propyl alcohol as a precursor in the medium and producing the same amounts of the antibiotic was obtained by means of step-wise selection with the use of a mutagen.
D000433:1-Propanol; D001737:Biuret / Q000031:analogs & derivatives / Q000494:pharmacology; D003470:Culture Media / Q000378:metabolism*; D004917:Erythromycin / Q000096:biosynthesis*; D009154:Mutation; D009602:Nitrosamines / Q000494:pharmacology; D013302:Streptomyces / Q000187:drug effects / Q000378:metabolism
D003470:Culture Media; D009602:Nitrosamines; C008654:N-nitroso-N-methylbiuret; D004917:Erythromycin; D001737:Biuret; D000433:1-Propanol
Iskliuchenie propilovogo spirta iz sredy dlia kul'tivirovaniia produtsenta éritromitsina.