The metabolism of 7H-dibenzo[c,g]carbazole, an N-heterocyclic aromatic, in the isolated perfused lung.
The metabolism of a carcinogenic N-heterocyclic aromatic, 7H-dibenzo[c,g]carbazole, was investigated in an isolated perfused rabbit lung preparation in a rat liver microsomes. A major metabolite produced in both preparation is the 7-hydroxydibenzo[c,g]carbazole. A substantial percentage of this metabolite is found in the tracheabronchi, which would be consistent with the high incidence of respiratory tract tumors due to dibenzo[c,g]carbazole.
D000818:Animals; D002227:Carbazoles / Q000378:metabolism*; D002273:Carcinogens / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D066298:In Vitro Techniques; D008168:Lung / Q000378:metabolism*; D008297:Male; D013058:Mass Spectrometry; D010477:Perfusion; D011817:Rabbits
D002227:Carbazoles; D002273:Carcinogens; C013478:7H-dibenzo(c,g)carbazole