Formation of nitroso compounds and mutagens from tranquilizers by drug/nitrite interaction.
The formation of nitroso compounds and mutagens by drug/nitrite interaction was screened for 14 tranquilizers. The drug (0.05 M) was reacted with nitrite (0.5 M) at pH 3-3.5. After 4 h at 37 degrees C, nitroso compound formation was observed for flupentixol, chlordiazepoxide, spiperone, thiothixene, and chlorprothixene in more than 40% yield. Mutagenicity was found in the reaction products of opipramol, chlordiazepoxide, bromazepam, thiothixene, and carpipramine by the Ames assay using Salmonella typhimurium TA98 and TA100 as tester strains.
D004347:Drug Interactions; D009153:Mutagens / Q000378:metabolism* / Q000633:toxicity; D009573:Nitrites / Q000378:metabolism* / Q000633:toxicity; D009603:Nitroso Compounds / Q000378:metabolism* / Q000633:toxicity; D014149:Tranquilizing Agents / Q000378:metabolism* / Q000633:toxicity
D009153:Mutagens; D009573:Nitrites; D009603:Nitroso Compounds; D014149:Tranquilizing Agents