[Thromboresistant properties of polyelectrolyte complexes based on weak polyelectrolytes].
Thrombogenic resistant polyelectrolyte compositions were obtained on the basis of weak polyelectrolytes used in different quantity proportions. The investigations were performed in vitro on rabbit blood and in vivo on 21 dogs and 5 calves in the conditions of acute and chronic experiments. The optimal compositions of polymers were selected for the implantation. The appropriate polyelectrolyte compositions on the basis of weak polyelectrolytes, and polymers modified by polyacryl acid with polyethylene piperazine (1:1, 2:1, 3:1), were found to be thrombogenic resistant and did not cause any significant blood cells damage. The investigations performed the possibility for their practical application.
D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery; D001672:Biocompatible Materials / Q000627:therapeutic use; D001807:Blood Vessel Prosthesis / Q000295:instrumentation; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005343:Fibrinolytic Agents; D007083:Iliac Artery / Q000601:surgery; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D011108:Polymers / Q000032:analysis / Q000627:therapeutic use*; D011817:Rabbits; D013927:Thrombosis / Q000517:prevention & control*
D001672:Biocompatible Materials; D005343:Fibrinolytic Agents; D011108:Polymers
Thromborezistentnye svoístva poliélektrolitnykh kompleksov na osnove slabykh poliélektrolitov.