[Nomifensin-induced immune haemolytic anaemias (author's transl)].
Two cases of immune haemolytic anaemia and acute renal failure induced by nomifensine are reported. The two female patients had been under continuous nomifensin therapy because of reactive depressions. In both cases nomifensine had been discontinued and the clinical reactions--immune haemolytic anaemia and acute renal failure--started immediately after they had taken again a capsule of nomifensine. In one case the patient's serum contained a potent antibody which agglutinated her red blood cells in presence of nomifensine in the antiglobulin test.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced*; D003298:Coombs Test; D003866:Depressive Disorder / Q000188:drug therapy*; D006801:Humans; D007546:Isoquinolines / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009627:Nomifensine / Q000009:adverse effects* / Q000627:therapeutic use; D006435:Renal Dialysis
D007546:Isoquinolines; D009627:Nomifensine
Immunhämolytische Anämien mit Nierenversagen nach Nomifensineinnahme.