Vitamin E supplementation and respiratory effects of ozone in humans.
To determine whether vitamin E (di-alpha-tocopherol) supplementation could protect against short-term respiratory responses to O3 exposure its effects were investigated in young healthy adult volunteers. Experimental groups received 800 or 1600 IU vitamin E per day for 9 or more wk, while control groups received placebo. Subjects were then exposed for 2-h periods to 0.5 ppm O3, with secondary stresses of heat and intermittent light exercise. Responses to O3 exposure, evaluated in terms of symptoms, forced expiratory performance, and single-breath nitrogen washout, were not significantly different between vitamin E and placebo groups.
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D010126:Ozone / Q000633:toxicity*; D012119:Respiration / Q000187:drug effects*; D012129:Respiratory Function Tests; D014810:Vitamin E / Q000494:pharmacology*
D014810:Vitamin E; D010126:Ozone