[Age-related changes in the lymphocytes as a model of aging].
Lymphocytes of spleen and lymph nodes of Wistar rats and CBA/Ca mice, as well as human peripheric lymphocytes have shown similar age related alterations. These alterations appeared in form of the loss of the mitochondrial christae which were replaced by myelin-like figures or filamentous structure. In some cases lymphocytes contained electron lucid material and giant mitochondria. These mitochondrial changes were seen in human T-lymphocytes. Authors believe that lymphocytes represent a suitable model for the study of the process of aging and also for testing factors influencing it.
D000375:Aging; D000818:Animals; D008198:Lymph Nodes / Q000648:ultrastructure; D008214:Lymphocytes / Q000502:physiology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure; D008954:Models, Biological; D051381:Rats; D013154:Spleen / Q000648:ultrastructure
A lymphocyták korral járó változása, mint az öregedés modellje.