Comparative pharmacoclinical evaluation between talampicillin and ampicillin in urinary infections.
500 mg of powdered ampicillin (AMP; activity 108%) and 325 mg of talampicillin chlorhydrate (TMP; equivalent to 200 mg ampicillin with an activity of 100%) were administered orally to two groups of 15 fasting patients selected at random. Blood samples were collected after 1/2, 1, 2, 4 and 6 h and urine samples after 1, 2, 4 and 6 h. The AMP concentrations were determined by the microbiologic method. All patients received food 1 h after the drugs administration. Urine samples wee taken daily for the bacteriologic examination. The maximum seric peak for TMP was 4.2 microgram/ml at 1/2 h and for AMP of 4.6 microgram/ml after 1 h. It was stated that TMP is absorbed more quickly than AMP and it was not affected by the presence of food. Nevertheless, no differences were observed in the results of the clinical study.
D000667:Ampicillin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006801:Humans; D013626:Talampicillin / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology
D013626:Talampicillin; D000667:Ampicillin