Co-carcinogenicity of promoting agents.
An experiment is described to investigate whether coadministration of a promoting agent would enhance the carcinogenicity of a repeatedly administered complete carcinogen. Topical application of the strong carcinogen 15,16-dihydro-11-methylcyclopenta[a]phenanthren-17-one (I) in toluene containing 1% v/v croton oil is about five times more effective than applications in toluene alone, as judged from the respective mean latent periods. A similar effect is also apparent for benzo[a]pyrene.
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D003043:Cocarcinogenesis; D003436:Croton Oil / Q000633:toxicity; D004785:Environmental Pollutants / Q000633:toxicity; D005260:Female; D006067:Gonanes / Q000633:toxicity; D008297:Male; D051379:Mice
D002273:Carcinogens; D004785:Environmental Pollutants; D006067:Gonanes; D003436:Croton Oil; C005765:15,16-dihydro-11-methylcyclopenta(a)phenanthren-17-one