Effects of nitric oxide on resistance to bacterial infection in mice.
Continuous exposure to 2 ppm nitric oxide (NO) for as long as 4 wk did not reduce the resistance of male mice to infection by aerosol inoculation with Pasteurella multocida. In contrast, mortality was slightly enhanced and survival shortened in NO-exposed compared to control female mice; however, the importance of these small differences is uncertain. These results suggest only that male and female mice did not react similarly to the infectious challenge after exposure to NO.
D000818:Animals; D005260:Female; D007113:Immunity, Innate / Q000187:drug effects; D008168:Lung / Q000473:pathology; D008297:Male; D051379:Mice; D009569:Nitric Oxide / Q000633:toxicity*; D010326:Pasteurella Infections / Q000276:immunology* / Q000382:microbiology; D013997:Time Factors
D009569:Nitric Oxide