[The tissue adhesion of the ruptured spleen with highly concentrated human fibrinogen (author's transl)].
After splenectomy the immunologic impairment and the susceptibility to infection is increased, but the most important impetus for splenic preservation has been the observation of the overwhelming postsplenectomy sepsis. Successful results with surgical repair of traumatized spleen and several different techniques have been reported. Instead of suture of splenorrhaphy we used in our experiences a new biological adhesive-system, consisting in thrombin, highly concentrated native human fibrinogen and clotting factor XIII. The highly adhesive properties, the excellent tissue compatibility and the haemostyptic effects recommend this system for using in preservation of the injured spleen as well as possible.
D000293:Adolescent; D000818:Animals; D004359:Drug Therapy, Combination; D005176:Factor XIII / Q000627:therapeutic use; D005340:Fibrinogen / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D051381:Rats; D013103:Spherocytosis, Hereditary / Q000601:surgery; D013156:Splenectomy; D013161:Splenic Rupture / Q000601:surgery*; D013917:Thrombin / Q000627:therapeutic use; D014014:Tissue Adhesives / Q000627:therapeutic use*
D014014:Tissue Adhesives; D005340:Fibrinogen; D005176:Factor XIII; D013917:Thrombin
Gewebeklebung der rupturierten Milz mit hochkonzentriertem Human-Fibrinogen.