[Significance and importance of enzyme diagnosis in the framework of toxicological studies of plant protectives, pesticides and agents for biological process control].
In toxicological experimentation, clinico-chemical and biochemical data are increasingly involved in the comprehensive evaluation of adverse effects of plant protectives, pesticides and agents for the biological process control on the mammalian organism. Blood serum and urine or organic homogenates from experimental animals kept under standardized conditions are chiefly used for enzymodiagnostic analyses. Changes in enzyme activity occurring under the influence of the bioactive test substances must be regarded as indicative of direct effects on the biocatalyst, metabolic changes or impairments of certain organs.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D002802:Cholinesterases / Q000097:blood; D004796:Clinical Enzyme Tests; D004798:Enzymes / Q000032:analysis*; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D008297:Male; D010575:Pesticides / Q000009:adverse effects* / Q000494:pharmacology; D051381:Rats; D014116:Toxicology
D004798:Enzymes; D010575:Pesticides; D002265:Carboxylic Ester Hydrolases; D002802:Cholinesterases
Bedeutung und Stellung der Enzymdiagnostik im Rahmen toxikologischer Untersuchungen von Pflanzenschutz-und Schädlingsbekämpfungsmitteln und Mitteln zur biologischen ProzeBsteuerung.