Comparative pharmacokinetics of cyclacillin and amoxicillin in infants and children.
Concentrations of cyclacillin in serum over a 6-h period were similar in fasted and milk-fed infants who received 25-mg/kg doses of cyclacillin suspension. Measured by the concentration in serum after oral administration of 15-mg/kg doses, cyclacillin was absorbed more rapidly, reached larger concentrations, and was cleared more promptly than was amoxicillin.
D000658:Amoxicillin / Q000378:metabolism* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002675:Child, Preschool; D003493:Cyclacillin / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D006207:Half-Life; D006801:Humans; D007223:Infant; D007700:Kinetics; D008297:Male; D010406:Penicillins / Q000378:metabolism*
D010406:Penicillins; D003493:Cyclacillin; D000658:Amoxicillin