Antitumor activity of flavonoids on NK/Ly ascites tumor cells.
Among the various flavonoids, rutin and quercetin increased the survival time of mice inoculated with NK/Ly ascites tumor cells. The best results were obtained when the mice were given 2.0 mg rutin twice daily for 8 days. The O-silyl-substituted rutin and quercetin were less effective than rutin or quercetin themselves. Besides rutin, quercetin and morin two other flavonoids, luteolin and pelargonidin also exerted growth inhibitory effects on NK/Ly ascites tumor cells cultures in vitro.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001201:Ascites / Q000188:drug therapy; D005419:Flavonoids / Q000494:pharmacology*; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D011794:Quercetin / Q000494:pharmacology; D012431:Rutin / Q000494:pharmacology
D000970:Antineoplastic Agents; D005419:Flavonoids; D012431:Rutin; D011794:Quercetin