Tissue distribution of 3H-corticosterone in response to stress.
The level and distribution of 3H-corticosterone (3H-B) was investigated in adult male Sprague-Dawley rats in response to diethyl ether stress, epinephrine (EP) and/or dexamethasone (DXM) administration. Diethyl ether stress caused a significant increase in the 3H-B counts by some of the body tissues and brain regions studied. Plasma 3H-B counts in the stressed rats were found to be twice as much as in the control animals. When EP (1.0 mg/kg) was injected, the tissue-plasma ratios(TPR) of 3H-B were significantly lower (P less than 0.05) than those of the dexamethasone (1.0 mg/kg) treated animals or the control group. The high 3H-B count in the plasma in response to diethyl ether stress or EP may indicate a decline in rate of corticosterone metabolism.
D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000378:metabolism*; D003907:Dexamethasone; D004837:Epinephrine; D004986:Ether; D008297:Male; D051381:Rats; D013312:Stress, Physiological / Q000139:chemically induced / Q000378:metabolism*; D014018:Tissue Distribution
D004986:Ether; D003907:Dexamethasone; D003345:Corticosterone; D004837:Epinephrine