The maturation of cortical serotonin binding sites.
Binding of serotonin to rat brain membranes increased linearly from birth to adulthood, but newborn receptor densities were already 39% of adult levels. These data suggest a postnatal development of serotonin receptors, coincident with synaptic maturation but do not preclude a non-transmitter function for serotonin during early maturation.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000378:metabolism*; D005260:Female; D008297:Male; D011247:Pregnancy; D051381:Rats; D011985:Receptors, Serotonin / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D013570:Synaptic Membranes / Q000378:metabolism
D011985:Receptors, Serotonin; D012701:Serotonin