1-Acyl-2-lysophosphatidylcholine: phosphatidylglycerol-2-acyltransacylase in lung microsomes and type II pneumocyte-derived cultures.
The formation of [3H]phosphatidylcholine from 1-acyl-2-lysophosphatidylcholine and 1-acyl-2-[9,10-3H]palmitoylphosphatidylglycerol, presumably by 1-acyl-2-lysophosphatidylcholine : phosphatidylglycerol-2-acyltransacylase (phosphatidylglycerol transacylase), was detected in lung microsomes and Set 4 type II pneumocyte-derived cultured cells but not in A549 adenocarcinoma-derived type II cell analogs. There was greater phosphatidylglycerol transacylase activity in Set 4 cells at confluence than at the mid-log stage. Since the phosphatidylglycerol transacylase activity was always markedly less than that observed for 1-acyl-2-lysophosphatidylcholine : acyl-CoA acyltransferase, the former does not appear to represent a major pathway for synthesis of pulmonary dipalmitoylphosphatidylcholine.
D000217:Acyltransferases / Q000378:metabolism*; D000230:Adenocarcinoma / Q000201:enzymology; D002460:Cell Line; D002478:Cells, Cultured; D006801:Humans; D008168:Lung / Q000201:enzymology*; D008175:Lung Neoplasms / Q000201:enzymology; D008861:Microsomes / Q000201:enzymology*
D000217:Acyltransferases