Organizing pneumonia-like process: an unusual observation in steroid responsive cases with features of chronic interstitial pneumonia.
Two patients under long-term surveillance showed the similar clinical features of low-grade fever, scanty productive cough, progressive dyspnea, and roentgenologic findings of lung infiltrates. Both patients responded only to systemic corticosteroid therapy and suffered relapses when it was discontinued. In one patient, who was found to be IgA-deficient, the pulmonary disease followed an episode of subacute thyroiditis; in this patient the intake of cephalosporin and subsequent rechallenge with the drug aggravated the disease. Needle biopsies in both patients showed the features of organizing intra-alveolar pneumonia. The histopathologic findings and their relation to the clinical symptoms are discussed.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D001707:Biopsy, Needle; D002511:Cephalosporins / Q000009:adverse effects; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D011650:Pulmonary Alveoli / Q000166:cytology / Q000000981:diagnostic imaging / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology; D011859:Radiography; D012129:Respiratory Function Tests; D013966:Thyroiditis / Q000150:complications
D000305:Adrenal Cortex Hormones; D002511:Cephalosporins