Impairment of blood-brain barrier (BBB) in rat by immobilization stress: role of serotonin (5-HT).
Influence of immobilization stress on blood-brain barrier (BBB) was studied in rats using Evans blue as barrier tracer. 7-9 hr of of immobilization had increased the permeability of BBB mainly in younger rats. This increased permeability was significantly reduced with p-CPA, indomethacin or vinblastine pretreatment. Theophylline treatment caused early extravasation of Evans blue dye. The increased level of serotonin in immobilization and infusion of 5-HT in model experiments suggest a causative role of serotonin in the increased permeability of BBB induced by immobilization stress.
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D005260:Female; D007103:Immobilization; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism* / Q000494:pharmacology; D013312:Stress, Physiological / Q000378:metabolism / Q000503:physiopathology*
D012701:Serotonin