Changes in tumor-specific nuclear antigen activity in carcinogen-treated colon by tumor promoter and carcinogen inhibitors.
Changes in the immunospecificity of the nuclear antigens were demonstrated in the colon chromatin of rats treated with 1,2-dimethylhydrazine. Tumor-specific nuclear antigen appeared in the early stages of chemically induced colon carcinogenesis. Sodium barbiturate, in conjunction with the carcinogen, induced a higher level of nuclear antigen activity than that obtained with carcinogen alone. The rise of immunoactivity in carcinogen-treated colon chromatin can be abolished by simultaneous treatment with disulfiram or butylated hydroxytoluene.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D001463:Barbiturates / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002467:Cell Nucleus / Q000187:drug effects / Q000276:immunology*; D002843:Chromatin / Q000276:immunology; D003043:Cocarcinogenesis; D003106:Colon / Q000187:drug effects* / Q000276:immunology; D003110:Colonic Neoplasms / Q000139:chemically induced; D004127:Dimethylhydrazines / Q000037:antagonists & inhibitors; D004221:Disulfiram / Q000494:pharmacology; D008297:Male; D008763:Methylhydrazines / Q000037:antagonists & inhibitors; D011230:Precancerous Conditions / Q000139:chemically induced / Q000276:immunology; D051381:Rats
D000951:Antigens, Neoplasm; D001463:Barbiturates; D002843:Chromatin; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D002084:Butylated Hydroxytoluene; D004221:Disulfiram