Chronic active hepatitis and giant multinucleated hepatocytes in adults treated with clometacin.
The authors report the cases of 2 adults who became jaundiced during prolonged administration of clometacin, a new analgesic drug. Jaundice and serum aminotransferase activity progressively increased while the drug administration was continued but quickly decreased when it was eventually interrupted. 1 patient resumed the intake of clometacin and died with jaundice and ascites. In both patients, liver lesions were those of severe chronic active hepatitis with numerous giant multinucleated hepatocytes.
D000368:Aged; D000700:Analgesics / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007210:Indoleacetic Acids / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008854:Microscopy, Electron
D000700:Analgesics; D007210:Indoleacetic Acids; C017136:clometacin