LDH isozymes in transplantable hamster tumours with different histogenesis and differentiation.
LDH isozymes were assayed by polyacrylamide gel electrophoresis in 6 long-term transplantable skin tumours in Syrian hamsters. The percentages of the M-subunits were as follows: in a slow growing fibrosarcoma with abortive differentiation and producing lung metastases -- 63.3; in two well differentiated squamous cell carcinomas with moderate growth -- 79.8 and 74.9; in a slow growing and metastasizing melanotic melanoma -- 67.7; in undifferentiated amelanotic and depigmented melanomas with very fat growth -- 72.8 and 77.4. Therefore no consistent relationship has emerged between histogenesis, growth rate, differentiation and metastases of the studied neoplasms from one side and their LDH isozyme pattern -- on the other.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000201:enzymology; D002460:Cell Line; D006224:Cricetinae; D005260:Female; D005354:Fibrosarcoma / Q000201:enzymology; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D008545:Melanoma / Q000201:enzymology; D008647:Mesocricetus; D009367:Neoplasm Staging; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000201:enzymology; D012878:Skin Neoplasms / Q000201:enzymology* / Q000473:pathology
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase