[Durene derivates. IV. N-((2,3,5,6-tetramethylbenzoyl)alkyl)imidazoles and N-((beta-(2,3,5,6-tetramethylphenyl)-beta-hydroxy)ethyl)imidazoles with anticonvulsant activity].
A series of N-[(2,3,4,6-tetramethylbenzoyl)alkyl]imidazoles and of N-([beta-(2,3,5,6-tetramethylphenyl)-beta-hydroxy]ethyl)imidazoles has been synthesized. All compounds were tested in mice for anticonvulsant activity against electroshock and pentylenetetrazole convulsions. These durene-derivatives showed good activity, whereas the corresponding benzene-derivatives were inactive.
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice
D000927:Anticonvulsants; D001555:Benzene Derivatives; D007093:Imidazoles; C023973:durene
Ulteriori richerche su derivati del durene. Nota IV - N-[(2,3,5,6-tetrametilbenzoil)alchil]imidazoli e N-([beta-(2,3,5,6-tetrametilfenil)-beta-idrossi]etil)imidazoli ad atività anticonvulsivante.