[In vitro cytolysis mediated by NK effectors: modification of the susceptibility of the target cell by in vivo treatment with DTIC].
An antigenically altered DTIC-treated tumor subline was tested for sensitivity to the cytotoxic activity of murine Natural Killer (NK) cells in comparison to that of the original (parental) tumor. Direct lysis assays and "cold" inhibition procedures showed that the DTIC-subline is consistently less susceptible to lysis that the parental tumor.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D003606:Dacarbazine / Q000494:pharmacology*; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000276:immunology*; D007940:Leukemia L5178 / Q000276:immunology*; D007942:Leukemia, Experimental / Q000276:immunology*; D051379:Mice
D003606:Dacarbazine
Citolisi in vitro mediata da effettori NK:modulazione della suscettibilità della cellula "target" per trattamento in vivo con DTIC.