Central and peripheral contributions to hypothalamic epinephrine.
Hypothalamic epinephrine concentrations were examined following adrenal demedullation or after surgical hemisection of ascending projections to the hypothalamus. Following surgical transection epinephrine in the ipsilateral hypothalamus was depleted by approximately 60%. Adrenal demedullation had no effect on hypothalamic epinephrine concentrations. It was concluded that hypothalamic epinephrine was central in origin.
D000313:Adrenal Medulla / Q000294:innervation*; D000818:Animals; D001933:Brain Stem / Q000201:enzymology*; D004292:Dominance, Cerebral / Q000502:physiology; D004837:Epinephrine / Q000378:metabolism*; D007031:Hypothalamus / Q000201:enzymology*; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D010625:Phenylethanolamine N-Methyltransferase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D010625:Phenylethanolamine N-Methyltransferase; D004837:Epinephrine