Xilobam: analysis, determination of decomposition products, and assessment of stability.
A stability-indicating UV assay was developed for xilobam, a member of a new class of CNS agents. The method was specific, precise, and accurate. TLC and high-pressure liquid chromatography were used to support method specificity. Xilobam is sensitive to heat, moisture, and basic conditions. The degradation products were identified as N-methylpyrrolidone, 2,6-dimethylaniline, and N,N'-bis(2,6-dimethyl-phenyl)urea. At high temperatures, the incorporation of molecular sieves into glass bottles of xilobam tablets was effective in preventing decomposition caused by moisture or volatile decomposition products.
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002855:Chromatography, Thin Layer / Q000379:methods; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D010671:Phenylurea Compounds / Q000032:analysis*; D011759:Pyrrolidines / Q000032:analysis*; D013607:Tablets
D010671:Phenylurea Compounds; D011759:Pyrrolidines; D013607:Tablets; C017798:xilobam