The effect of triiodothyronine on weight loss and nitrogen balance of obese patients on a very-low-calorie liquid-formula diet.
During drastic calorie restriction triiodothyronine (T3) administration results in an increase in weight loss and the metabolic rate. The effects of T3 on nitrogen balance under these circumstances was studied in 11 obese patients under metabolic ward conditions. These patients received a 320 kcal (1.34 MJ) diet containing 31 g of milk protein, and were given 25 micrograms T3 orally at eight hourly intervals from the 20th day. Mean daily weight loss increased significantly from 269 +/- 27 g/day to 395 +/- 32 g/day, while net N balance did not change significantly. These results suggest that T3 administration while increasing weight loss does not necessarily cause a deterioration in N balance, at least during the early phases of use of very-low-calorie mixed diets.
D000328:Adult; D001835:Body Weight; D003404:Creatinine / Q000652:urine; D004038:Diet, Reducing / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000378:metabolism*; D009765:Obesity / Q000178:diet therapy* / Q000378:metabolism; D013963:Thyroid Hormones / Q000097:blood; D014284:Triiodothyronine / Q000008:administration & dosage / Q000494:pharmacology*
D013963:Thyroid Hormones; D014284:Triiodothyronine; D003404:Creatinine; D009584:Nitrogen