Improved methotrexate therapy of murine tumors obtained by probenecid-mediated pharmacological modulation at the level of membrane transport.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D001853:Bone Marrow / Q000378:metabolism; D005260:Female; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008727:Methotrexate / Q000378:metabolism / Q000627:therapeutic use*; D051379:Mice; D008815:Mice, Inbred Strains; D011339:Probenecid / Q000494:pharmacology*; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000378:metabolism
D011339:Probenecid; D008727:Methotrexate