Lysosomal enzymes in sera and granulocytes of patients with chronic liver diseases.
The authors have measured the activity of acid phosphatase, beta-glucuronaidase and cathepsin-D in tthe sera of patients with different liver diseases, and the actvity of beta-glucuronidase in granulocytes and the rate of its release. Using the method for the releaseof beta-glucuronidase from the granulocytes they drew conclusions to thedegree of the membrane-damage occurring in the liver diseases. They provided that in the sera of patients with different liver diseases the increase in the activity of the acid phosphatase and the beta-glucuronidase is different. According to their in vitro studies the decrease in the beta-glucuronidase activity measured in the granulocytes, and the release of enzyme is in connection with the type of liver disease and with the different degree of lysosomal membrane alteration.
D000135:Acid Phosphatase / Q000097:blood; D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D005966:Glucuronidase / Q000097:blood; D006098:Granulocytes / Q000201:enzymology* / Q000648:ultrastructure; D006505:Hepatitis / Q000201:enzymology; D006801:Humans; D008103:Liver Cirrhosis / Q000201:enzymology; D008107:Liver Diseases / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged
D000135:Acid Phosphatase; D005966:Glucuronidase