[Ultrastructural and experimental study of the ocular toxicity of antibiotics and antifungals on the corneal endothelium (author's transl)].
The authors report an experimental study on the ocular toxicity of some antibiotics (ampicillin, gentamicin, cephalotin sodic, tobramycin) and some antifungals (amphotericin B, flucytosin). For this study they used both the transmission electron microscope and the scanning microscope. The most important modifications of the corneal endothelium were observed with amphotericin b, flucytosin. cephalotin sodic. The toxicity seems to be lower with gentamicin and with tobramycin. Ampicillin produced few visible changes. This study was realized with the aim to determine the quantities of antimicrobials that could be injected in the human eye without corneal lesions in the treatment of endophthalmitis (bacterial or fungal).
D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000935:Antifungal Agents / Q000009:adverse effects*; D003315:Cornea / Q000187:drug effects / Q000648:ultrastructure; D003316:Corneal Diseases / Q000139:chemically induced*; D004727:Endothelium / Q000187:drug effects; D008854:Microscopy, Electron; D011817:Rabbits
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents
Etude expérimentale en ultrastructure de la toxicité des antibiotiques ou des antifongiques sur l'endothélium cornéen.