Physical properties and dissolution profiles of acetaminophen and acetylsalicyclic acid tablets made from sucrose-based vehicles.
Di-pae, Sugartab and Nu-Tab were used as direct compressible vehicles for acetaminophen and acetylsalicylic acid tablets. Direct compressible grades on lactose and Avicel were used as vehicles for comparison. Three different packing fractions were employed for tabletting acetaminophen and acetylsalicylic acid. The physical properties and dissolution characteristics of the prepared tablets depend on their packing fraction i.e. the mechanical strength, and disintegration and dissolution time are lowest at the lowest packing fraction and vice versa. It was found that the time required for maximum dissolution rate (t90) of drug was usually longer than the disintegration times of tablets and also t90 of acetylsalicylic acid was found to be faster than that of acetaminophen with all tested vehicles.
D000082:Acetaminophen; D001241:Aspirin; D002626:Chemistry, Pharmaceutical; D006244:Hardness; D014677:Pharmaceutical Vehicles; D012995:Solubility; D013395:Sucrose; D013607:Tablets; D013997:Time Factors
D014677:Pharmaceutical Vehicles; D013607:Tablets; D000082:Acetaminophen; D013395:Sucrose; D001241:Aspirin