[Suppressive action of bone marrow and spleen cells on antibody genesis and lymphoid cell proliferation in an in vitro culture of autoimmune mice (NZB.NZW)F1].
The ability of bone marrow and spleen cells of autoimmune (NZB.NZW) F1 strain of mice of various age to suppress the immune response and spleen cells proliferation of young syngeneic mice in vitro was studied. The SRBC were used as an antigen. The proliferation rate was measured by the intensiveness of 3H-thymidine incorporation into DNA of cells being in the process of division. It has been found out that the bone marrow supressive activity in (NZB.NZW) F1 strain of mice undergoes age-associated changes. In mice 4-5 months of age the temporary reduction of suppressor-cell activity in the bone marrow is observed. The bone marrow suppressive activity recovers by 8-10 months, reaching the level of that observed in mice 1.5-2 months of age. In the spleens of (NZB.NZW) F1 strain of 8-10 months old mice suppressor cells appear lacking in young animals. The possibility of bone marrow B-suppressor participation in the development of the autoimmune process in (NZB.NZW) F1 strain of mice is discussed.
D000375:Aging; D000818:Animals; D000917:Antibody Formation; D001323:Autoantibodies / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology*; D001854:Bone Marrow Cells; D002455:Cell Division; D002478:Cells, Cultured; D005260:Female; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008814:Mice, Inbred NZB / Q000276:immunology*; D013154:Spleen / Q000166:cytology / Q000276:immunology*
D001323:Autoantibodies
Supressivnoe deĭstvie kletok kostnogo mozga i selezenki na antitelogenez i proliferatsiiu limfoidnykh kletok v kul'ture in vitro u autoimmunnykh mysheĭ (NZB.NZW)F1.