Malignant lentigo-melanoma--a comparative histological and electron microscopy study.
We examined, by light and electron microscopy, three cases of malignant lentigo, one of which was in the vertical growth phase. The purpose of our work was to compare the diverse patterns between superficial spreading melanoma and malignant lentigo. The observations suggest the following major findings: 1) the cells of malignant lentigo differ from normal melanocytes, and in the same specimen they differ from one another; 2) in malignant lentigo, melanosomes at stage II-IV are visible; and 3) in spreading melanoma, the melanosomes do not attain complete maturation. These morphological features explain the different behaviour of these two types of tumors.
D002467:Cell Nucleus / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic; D006801:Humans; D008544:Melanocytes / Q000648:ultrastructure; D008545:Melanoma / Q000648:ultrastructure*; D008854:Microscopy, Electron; D009508:Nevus, Pigmented / Q000648:ultrastructure*; D012878:Skin Neoplasms / Q000648:ultrastructure*