In vitro detection of possible in vivo drug interactions. Part 2: A study of the effect of hydrochlorothiazide and frusemide on the partition coefficient and solubility characteristics of propranolol hydrochloride.
The apparent partition coefficient (Kapp.) of propranolol hydrochloride alone and in the presence of hydrochlorothiazide and frusemide were determined between chloroform and artificial intestinal juice. Both diuretics significantly reduced the relatively high Kapp. of propranolol hydrochloride. On the other hand, the relatively low Kapp. of both diuretics were significantly increased by the presence of propranolol hydrochloride. Also in vitro solubility studies were carried out using the Sartorius solubility simulator. The frequently prescribed therapeutic combination of propranolol hydrochloride tablets and either hydrochlorothiazide or frusemide tablets seems, on the whole to have similar in vitro solubility patterns when compared to those of the individual drugs. However, the mutual effects on the apparent partition coefficient revealed in the present work can be one of the factors responsible for improving the in vitro absorption of propranolol hydrochloride and the diuretics when present together.
D002626:Chemistry, Pharmaceutical; D004347:Drug Interactions; D005665:Furosemide; D006852:Hydrochlorothiazide; D011433:Propranolol / Q000008:administration & dosage; D012995:Solubility; D013607:Tablets; D013997:Time Factors
D013607:Tablets; D006852:Hydrochlorothiazide; D005665:Furosemide; D011433:Propranolol