A comparison of the effects of propranolol and oxprenolol on forearm blood flow and skin temperature.
1 The effects of oxprenolol 80 mg and propranolol 80 mg on resting forearm blood flow (RFBF) and skin temperature were compared in seven normotensive subjects, for 4 h after an oral dose. 2 There was a significant fall of RFBF after propranolol (mean +/- s.e. mean 0.74 +/- 0.24 ml 100 g-1 min-1) compared to a smaller non-significant reduction after oxprenolol (0.35 +/- 0.19 ml 100 g-1 min-1). Propranolol produced a greater fall in heart rate than oxprenolol at all times except at 2.5 h. Three subjects experienced falls in skin temperature of over 4 degrees C with propranolol. There were no comparable falls after oxprenolol. 3 The results suggest that at the same dose oxprenolol has less effect on RFBF and skin temperature than propranolol.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D005542:Forearm / Q000098:blood supply*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D010096:Oxprenolol / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D012881:Skin Temperature / Q000187:drug effects*; D013997:Time Factors
D010096:Oxprenolol; D011433:Propranolol