Studies on drug metabolism by use of isotopes XXVI: Determination of urinary metabolites of rutin in humans.
Determination of urinary metabolites of orally administered rutin and rutin-2',5',6'-d3 in humans was carried out by TLC and GLC-mass spectrometry. In human urine, 3-hydroxyphenylacetic acid, 3-methoxy-4-hydroxyphenylacetic acid, 3,4-dihydroxyphenylacetic acid, 3,4-dihydroxytoluene, and beta-m-hydroxyphenylhydracrylic acid were identified as rutin metabolites. Unchanged rutin and quercetin were not present in urine.
D001711:Biotransformation; D002849:Chromatography, Gas / Q000379:methods; D002855:Chromatography, Thin Layer / Q000379:methods; D006801:Humans; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D012431:Rutin / Q000652:urine*
D012431:Rutin