In vitro synergism of FR-31564, a new phosphonic acid antibiotic.
Against most test strains of Gram-negative bacilli, the in vitro effect of FR-31564 together with beta-lactam antibiotics or trimethoprim was strongly synergistic; with tetracycline and nalidixic acid the effect was additive; and with gentamicin and sulfamethoxazole the effect was additive or antagonistic. FR-31564 was markedly synergistic with beta-lactam antibiotics against beta-lactam antibiotic-resistant Gram-negative bacilli such as Klebsiella pneumoniae, Enterobacter aerogenes, E. cloacae, Citrobacter freundii and Serratia marcescens. The combination of FR-31564 with beta-lactam antibiotics effected a reduction of MICs against most of the test strains to clinically achievable concentrations in human serum.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004357:Drug Synergism; D005578:Fosfomycin / Q000031:analogs & derivatives / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D005578:Fosfomycin; C024640:fosmidomycin