Tissue distribution of [14C]ethambutol in mice.
Fifteen male mice were given oral doses of 32 mg [14C]ethambutol/kg in a study of the tissue distribution of the drug. Animals were killed 1, 2, 4, 7, and 24 h after dosage and radioactivity in various tissues was measured. Peak concentrations were seen at 2 h after dosage. With the exception of brain, all tissues examined (liver, kidney, heart, spleen, lung, and muscle) developed tissue-to-plasma concentration ratios greater than 2. Highest values were seen in liver, kidney, and lung. High lung values were viewed as a favorable attribute for a drug used in the treatment of tuberculosis.
D000284:Administration, Oral; D000818:Animals; D002250:Carbon Radioisotopes / Q000378:metabolism*; D004977:Ethambutol / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D051379:Mice; D013997:Time Factors; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D004977:Ethambutol