Lack of genic variation in the abundant proteins of human kidney.
Abundant proteins of 25 human kidneys were surveyed for genic variation by means of two-dimensional electrophoresis. Eighty-three (83) proteins were scored, and no genic variation was detected. This reduction in genic heterozygosity corroborates results determined with two-dimensional electrophoresis in mice and flies. These results suggest that previous estimates of electrophoretic variation may have been in error because of biased selection of loci.
D004591:Electrophoresis, Polyacrylamide Gel; D005787:Gene Frequency; D014644:Genetic Variation; D006579:Heterozygote; D006801:Humans; D007526:Isoelectric Point; D007668:Kidney / Q000502:physiology*; D008970:Molecular Weight; D011506:Proteins / Q000235:genetics*
D011506:Proteins