Antidiuretic effects of intracerebroventricular infusion of adrenaline in conscious goats.
The effects of adrenaline (A) upon waterdiuresis were studied in conscious, hydrated goats, provided with a permanent cannula into the 3rd ventricle. Adrenaline induced a reduction in urinary volume and in free water clearance and a rise in the osmolality of the urine. These effects were dose-dependent and significant. A biphasic Cl-excretion pattern, consisting op of an initial fall below control level and a subsequent increase was observed. Na+ and K+ excretion rates were reduced. Central pretreatment with phentolamine completely antagonized the antidiuretic action of A. Propranolol, atropine and hexamethonium were ineffective. Alpha-adrenoceptors might be involved in vasopressin release.
D000818:Animals; D002712:Chlorides / Q000652:urine; D004231:Diuresis / Q000187:drug effects*; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007276:Injections, Intraventricular; D010646:Phentolamine / Q000494:pharmacology; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine
D002712:Chlorides; D012964:Sodium; D011188:Potassium; D004837:Epinephrine; D010646:Phentolamine