Prostaglandin F2 alpha effects on the early mouse embryo.
Subcutaneous treatment of pregnant mice with 50, 100 and 200 micrograms PGF 2 alpha on gestational day 5 and 200 micrograms on gestational day 3 or 6 resulted in fetal growth retardation. Litter size was significantly reduced following treatment with 50 micrograms or 100 micrograms PGF 2 alpha on day 6 of pregnancy and the incidence of resorptions was increased following treatment with 50 micrograms on gestational day 6.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D005865:Gestational Age; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010920:Placenta / Q000187:drug effects; D011247:Pregnancy; D011460:Prostaglandins F / Q000494:pharmacology*
D011460:Prostaglandins F