[Structure of adrenal glands removed for hyperandrogenism and their hormone production in tissue culture].
Authors studied the surgically removed adrenals of a 16 year old girl with hyperandrogenism in tissue culture. The majority of cells in the initial culture was similar to the cells of the normal human adrenal. In the 6 weeks tissue culture the morphology of the cells has shown an alteration. The majority of them contained a small number of lipid droplets, abundant quantity of lysosomes and autophage vacuole. At this period in the media the progesterone level appeared to be elevated. Two months later in the tissue culture numerous transformed cells could be seen and the progesterone level of the media was low. It is believed that alteration of the biosynthesis of progesterone may have a role in the increased production of testosterone and in virilization.
D000293:Adolescent; D000311:Adrenal Glands / Q000378:metabolism / Q000648:ultrastructure*; D000312:Adrenal Hyperplasia, Congenital / Q000473:pathology* / Q000601:surgery; D000315:Adrenalectomy; D046508:Culture Techniques; D005260:Female; D006801:Humans; D011374:Progesterone / Q000096:biosynthesis / Q000378:metabolism; D013739:Testosterone / Q000096:biosynthesis / Q000378:metabolism
D013739:Testosterone; D011374:Progesterone
Hyperandrogenismus miatt eltávolított mellékvesék szerkezete és hormontermelése szövettenyészetben.