Thymidine: inhibitor of differentiation in the young chick blastoderm in culture.
Differentiation in the young chick blastoderm is affected by thymidine at concentrations higher than 8.2 x 10(-4) M. Blastoderms at the hypoblastic island stage cultured continuously in the presence of thymidine form an atypical primitive streak which is not capable of inducing the embryonic axis. However, blastoderms with a mature streak escape the effect of thymidine and develop normally.
D000818:Animals; D001756:Blastoderm / Q000187:drug effects* / Q000502:physiology; D002642:Chick Embryo; D046508:Culture Techniques; D005775:Gastrula / Q000502:physiology; D009024:Morphogenesis / Q000187:drug effects; D013936:Thymidine / Q000494:pharmacology*
D013936:Thymidine