Styrene and styrene oxide induce SCEs and are metabolised in human lymphocyte cultures.
Both styrene and its presumed active metabolite styrene oxide show dose response as potent inducers of sister chromatid exchanges (SCEs) in human lymphocyte cultures. The SCE inducing and clastogenic capacity of styrene in lymphocytes in vitro can be explained by gas chromatographically measurable increase of styrene oxide in styrene treated cultures.
D001711:Biotransformation; D002478:Cells, Cultured; D002849:Chromatography, Gas; D003434:Crossing Over, Genetic / Q000187:drug effects*; D004852:Epoxy Compounds / Q000097:blood / Q000494:pharmacology*; D004988:Ethers, Cyclic / Q000494:pharmacology*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008741:Methyl Methanesulfonate / Q000494:pharmacology; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013343:Styrenes / Q000378:metabolism / Q000494:pharmacology*
D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D013343:Styrenes; C013690:styrene oxide; D008741:Methyl Methanesulfonate