Sex and age differences in the specific activity of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase in human fetal kidney tissue.
The specific activity of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) was significantly greater (P less than 0.005) in human kidney tissue obtained from male abortuses aged 10--16 weeks after conception than in female abortuses of the same gestational age and in younger male and female abortuses. There was a significant correlation (r = 0.93, P less than 0.001) between the specific activity of PGDH in fetal kidney and testicular tissues obtained from human abortuses of 10--26 weeks gestational age. These results suggest a role for testosterone in the regulation of PGDH activity in the fetal kidney.
D005260:Female; D005333:Fetus / Q000201:enzymology*; D005865:Gestational Age; D006801:Humans; D006911:Hydroxyprostaglandin Dehydrogenases / Q000378:metabolism*; D007668:Kidney / Q000196:embryology* / Q000201:enzymology; D008297:Male; D009243:NAD; D012737:Sex Factors; D013737:Testis / Q000196:embryology / Q000201:enzymology
D009243:NAD; D006911:Hydroxyprostaglandin Dehydrogenases