[Experimental allergy to penicillin].
The inhalation method for penicillin sensitization with a long-term excitation of the respiratory tract mucosa with formalin was studied in experiments with rabbits. It was shown that inhalation of formalin significantly increased the frequency of the animal sensitization to penicillin. It is suggested that inflammation due to the formalin effect promoted penicillin binding by tissue proteins with formation of full value antigens from penicillin which resulted in the high frequency of the animal sensitization. The data may be used in studies on the allergenic properties of drugs.
D000818:Animals; D004342:Drug Hypersensitivity / Q000276:immunology*; D005557:Formaldehyde / Q000276:immunology; D007114:Immunization / Q000379:methods; D010406:Penicillins / Q000276:immunology*; D011817:Rabbits; D012130:Respiratory Hypersensitivity / Q000139:chemically induced / Q000276:immunology; D013997:Time Factors
D010406:Penicillins; D005557:Formaldehyde
Allergiia k penitsillinu v éksperimente.