Acathisia-syndrome: involvement of noradrenergic mechanisms.
The involvement of noradrenergic mechanisms in patients suffering from acathisia was investigated by determination of urinary night-time 3-methoxy-4-hydroxy-phenyl glycol (MHPG)-excretion and was compared both with control patients matched according to age and sex and healthy individuals. A significantly reduced MHPG excretion was found among the acathisia patients. It is suggested that a supersensitivity of the spinal noradrenergically innervated receptors caused by their long-term blocking is responsible for occurrence of the symptoms.
D000328:Adult; D005260:Female; D006018:Glycols / Q000652:urine*; D006801:Humans; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D008875:Middle Aged; D011595:Psychomotor Agitation / Q000150:complications / Q000652:urine*; D012016:Reference Values; D012559:Schizophrenia / Q000150:complications / Q000652:urine; D013577:Syndrome
D006018:Glycols; D008734:Methoxyhydroxyphenylglycol