Effect of verapamil on the pulmonary vasoconstrictor action of prostaglandin F2 alpha and a synthetic PGH2 analogue.
1 The vasopressor response to prostaglandin F2 alpha (PGF2 alpha) and to ((15S)-hydroxy-11 alpha, 9 alpha-(epoxymethano)-prosta-5Z, 13E-dienoic acid) (U-46619) in the canine isolated lung lobe was significantly attenuated following the administration of verapamil. 2 The pressor response to arachidonic acid (AA) was not affected by the presence of verapamil. 3 The pulmonary pressor effect of PGF2 alpha and U-46619 is dependent, at least in part, on Ca2+ influx into vascular smooth muscle cells. 4 The pulmonary pressor response to AA cannot be attributed to PGF2 alpha or to endoperoxide intermediates but to some other product dependent on intracellular calcium stores.
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D004285:Dogs; D005260:Female; D008297:Male; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D011463:Prostaglandins H / Q000494:pharmacology; D011652:Pulmonary Circulation / Q000187:drug effects*; D014661:Vasoconstriction / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology*
D001095:Arachidonic Acids; D011450:Prostaglandin Endoperoxides, Synthetic; D011460:Prostaglandins F; D011463:Prostaglandins H; D014700:Verapamil; D002118:Calcium