Effects of the hypoxic radiosensitizer misonidazole on normal and irradiated epidermis.
Misonidazole, a hypoxic cell radiation-sensitizer, has been used in vivo to analyze its effect on normal and x-irradiated epidermis. The drug action was evaluated 3 days after being implanted subcutaneously. The response of the epidermis and especially of the basal cells to the drug alone and in combination with x-radiation was studied. The ultramorphological analysis as well as quantitative data on epidermal thickness and keratinocyte volume showed that high doses of misonidazole impair the usual post-irradiation epidermal reaction, thus enhancing the involutional effects of radiation and inhibiting radiation-damage repair, even under conditions or normal oxygenation.
D000818:Animals; D004817:Epidermis / Q000187:drug effects / Q000473:pathology; D008920:Misonidazole / Q000494:pharmacology*; D009593:Nitroimidazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects
D009593:Nitroimidazoles; D008920:Misonidazole