[Effect of sodium hydroxybutyrate on mitochondrial oxidative phosphorylation and myocardial pentose cycle enzymes during high altitude hypoxia].
The effect of intraperitoneal administration of sodium hydroxybutyrate on oxidative phosphorylation in mitochondria and on the activity of glucoso-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in the cardiac muscle was studied under alpine conditions (3200 m above the sea level). The drug was shown to increase the conjugation of oxidation with phosphorylation, to potentiate the activity of the test enzymes of the pentose cycle in the heart of the animals with one-month long adaptation to high-altitude hypoxia.
D000064:Acclimatization / Q000187:drug effects; D000531:Altitude; D000818:Animals; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006885:Hydroxybutyrates / Q000494:pharmacology*; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects; D009206:Myocardium / Q000201:enzymology*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010100:Oxygen; D010101:Oxygen Consumption / Q000187:drug effects; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism; D051381:Rats; D012978:Sodium Oxybate / Q000494:pharmacology*
D006885:Hydroxybutyrates; D012978:Sodium Oxybate; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D010100:Oxygen
Vliianie natriia oksibutirata na okislitel'noe fosforilirovanie mitokhondriĭ i aktivnost' fermentov pentoznogo tsikla miokarda pri vysokogornoĭ gipoksii.