[Nicotinamide coenzyme concentration in the myocardium of growing rats during alpha- and beta-adrenergic blockade].
The total content of oxidized (NAD+ plus NADP+) and reduced (NAD . H/ plus NADP . H2) forms of nicotinamide-adenine dinucleotides was detected in the myocardium of 7, 30-day- and 3--5 month-old (adult) noninbred white rats exposed to the alpha-adrenoblockers dibenamine and phentolamine (5 mg/kg) and to the beta-adrenoblockers anaprilin and alfeprol (1 mg/kg). It was shown that the content of nicotinamide coenzymes in the myocardium of growing rats exposed to different adrenoblockers changes depending on neurohumoral regulation and metabolism of the heart muscle within each age period.
D000367:Age Factors; D000526:Alprenolol / Q000494:pharmacology*; D000818:Animals; D003983:Dibenzylchlorethamine / Q000494:pharmacology; D005260:Female; D008297:Male; D009206:Myocardium / Q000032:analysis*; D009243:NAD / Q000032:analysis*; D009249:NADP / Q000032:analysis*; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D013565:Sympatholytics / Q000494:pharmacology*
D013565:Sympatholytics; D009243:NAD; D003983:Dibenzylchlorethamine; D009249:NADP; D000526:Alprenolol; D010646:Phentolamine
Soderzhanie nikotinamidnykh kofermentov v miokarde rastushchikh krys pri alpha- i beta-adrenergicheskoĭ blokade.