Activity of lysosomal enzymes in the heart muscle of healthy and hydrazinophtalazine-treated rats after isoprenaline injury.
Heart damage was produced by isoprenaline injection in healthy and hydrazinophtalazine-treated rats. The activity of beta-glucuronidase, beta-acetyloglucosaminase and acid phosphatase was determined in the heart muscle, liver and blood serum. The activity of the studied enzymes increased in the seventh day of experiment and after two weeks after injection was normalized. The increase in the enzyme activity in hydrazinophtalazine-treated animals was significantly lower than in healthy animals.
D000818:Animals; D006321:Heart / Q000187:drug effects; D006830:Hydralazine / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology*; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D051381:Rats
D006830:Hydralazine; D007545:Isoproterenol