Evidence for neuronal localization of histamine-N-methyltransferase in rat brain.
There is evidence that histamine may be a neurotransmitter in mammalian brain. Histamine in neurons of the central nervous system is easily released and rapidly turned over. The cellular localization of histamine-N-methyltransferase, the proposed histamine-inactivating enzyme, was investigated by measuring its activity in rat striatum after applying neurochemical or electrolytic lesions. The results indicate a major neuronal localization of the enzyme in this area.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D003342:Corpus Striatum / Q000201:enzymology; D006637:Histamine N-Methyltransferase / Q000378:metabolism*; D007031:Hypothalamus / Q000502:physiology; D007608:Kainic Acid / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D008780:Methyltransferases / Q000378:metabolism*; D009474:Neurons / Q000201:enzymology*; D051381:Rats
D008780:Methyltransferases; D006637:Histamine N-Methyltransferase; D007608:Kainic Acid