Pharmacokinetics of trimethoprim and sulfadiazine in the dog: urine concentrations after oral administration.
Serial blood samples were obtained from 12 healthy adult dogs given equivalent subcutaneous and oral doses of the antibacterial combination, trimethoprim-sulfadiazine (1:5). By using a 1-compartment open model, pharmacokinetic parameters for both drugs were estimated from the mean serum concentration data after oral administration. Trimethoprim and sulfadiazine were rapidly absorbed, reaching maximum concentrations in 1 and 4 hours with serum elimination half-lives of 2.5 and 9.9 hours, respectively. After a single oral dose (30 mg/kg, combined ingredients) was given, both drugs were present in urine for up to 24 hours at concentrations exceeding the minimum inhibitory concentrations for common pathogenic bacteria.
D000284:Administration, Oral; D000818:Animals; D004285:Dogs / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D013411:Sulfadiazine / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D014295:Trimethoprim / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine
D013411:Sulfadiazine; D014295:Trimethoprim