Immune complexes facilitate uptake of antigen from the gut.
Radiolabeled DNP-ovalbumin was injected with and without DNP-specific antibody into ligated gut segments of neonatal rats. The transfer of this labeled protein to mesenteric lymph nodes and binding to gut tissue was examined. When the antigen, DNP-ovalbumin, was present in the gut in an immune complex from a selective localization of antigen in the mesenteric lymph node was observed. These data suggest that immune complexes in milk could potentially modulate neonatal immunological development.
D000818:Animals; D000936:Antigen-Antibody Complex; D000941:Antigens / Q000276:immunology*; D001665:Binding Sites; D004136:Dinitrobenzenes / Q000276:immunology; D007421:Intestine, Small / Q000276:immunology*; D051379:Mice; D008805:Mice, Inbred A; D010047:Ovalbumin / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains
D000936:Antigen-Antibody Complex; D000941:Antigens; D004136:Dinitrobenzenes; D010047:Ovalbumin