[Calcium-containing antacids in the therapy of duodenal ulcers].
The neutralization of acid by antacids and the inhibition of acid secretion by H2-receptor antagonists are the two essential factors in the standard therapy for peptic ulcer disease. In order to determine whether a high dosage therapy with a calcium-containing antacid accelerates the healing of the ulcer or retards it through the "Acid-rebound" effect of the calcium, we examined in a clinical study 10 patients with an endoscopically proven duodenal ulcer. After 2 weeks the duodenal ulcer was healed in 5 of the 10 patients. Thus a rate of healing was attained which was achieved in our clinic with a daily dosage of 1200 mg or 800 mg of cimetidine or with a Mg/Al-hydroxide-containing antacid in a daily dosage of 560 mval neutralization capacity in duodenal ulcer patients. On the other hand there was a difference in the healing of the ulcer between the methods of treatment presented and the exclusive dose of a placebo.
D000863:Antacids / Q000627:therapeutic use*; D002118:Calcium / Q000627:therapeutic use*; D002927:Cimetidine / Q000627:therapeutic use; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000188:drug therapy*; D004724:Endoscopy; D006801:Humans; D008274:Magnesium / Q000627:therapeutic use; D010919:Placebos
D000863:Antacids; D010919:Placebos; D002927:Cimetidine; D008274:Magnesium; D002118:Calcium
Kalzium-haltige Antazida und Ulcus duodeni-Heilung.