Identification of the unmyelinated sensory nerves which evoke plasma extravasation in response to antidromic stimulation.
Antidromic stimulation of single polymodal nociceptive C fibres in the rat's hind leg evoked a localized (about 6 m2) increase in vascular permeability of the skin as shown by the leakage of Evan's blue dye from the circulation. This effect was not observed with stimulation of single C low threshold mechanosensitive or warm-sensitive fibres, or of single C fibres for which a peripheral receptive field could not be identified.
D000818:Animals; D004558:Electric Stimulation; D005260:Female; D005267:Femoral Nerve / Q000502:physiology; D008297:Male; D009186:Myelin Sheath / Q000502:physiology*; D009619:Nociceptors / Q000502:physiology*; D051381:Rats; D012039:Regional Blood Flow; D012501:Saphenous Vein / Q000294:innervation*; D012867:Skin / Q000098:blood supply* / Q000294:innervation