[Protection of myocardial mitochondria from penetration by calcium ions using isoquinoline and phenothiazine derivatives].
It has been established that malonate-like action of isoquinoline derivatives (papaverine and nospan) on respiratory function of myocardial mitochondria leads to inhibition of the accumulation rate of Ca2+ by these organelles on the use of glutamate and alpha-ketoglutarate as substrates. A greater inhibition of Ca2+ transport rate in the mitochondria is observed in the presence of glutamate. It has been validated theoretically that the decreased intensity of Ca2+ accumulation is aimed at protecting the mitochondria from irreversible lesions in ischemia. Nitroglycerin and sodium nitrite do not affect Ca2+ exchange in the mitochondria.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D005260:Female; D005971:Glutamates / Q000378:metabolism; D007656:Ketoglutaric Acids / Q000378:metabolism; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism*; D009628:Nonachlazine / Q000494:pharmacology*; D010208:Papaverine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010640:Phenothiazines / Q000494:pharmacology*; D011398:Promethazine / Q000494:pharmacology*; D051381:Rats
D005971:Glutamates; D007656:Ketoglutaric Acids; D010640:Phenothiazines; D009628:Nonachlazine; C005317:drotaverin; D010208:Papaverine; D011398:Promethazine; D002118:Calcium
Zashchita proizvodnymi izokhinolina i fenotiazina mitokhondriĭ miokarda ot proniknoveniia v nikh ionov kal'tsiia.