Enkephalins induce asymmetrical effects on posture in the rat.
Enkephalins when applied subarachnoidally induce hind limb postural asymmetry in rats with transected spinal cord. The effect is antagonized by naloxone. Methionine-enkephalin induces predominantly left limb flexions while leucine-enkephalin causes mostly right limb flexions. The data suggest an asymmetry existing in the enkephalinergic system in the rat spinal cord.
D000818:Animals; D004723:Endorphins / Q000494:pharmacology*; D004743:Enkephalin, Leucine; D004744:Enkephalin, Methionine; D004745:Enkephalins / Q000494:pharmacology*; D007839:Functional Laterality / Q000502:physiology*; D006614:Hindlimb / Q000187:drug effects; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D006005:Phosphorylases / Q000037:antagonists & inhibitors*; D011187:Posture; D051381:Rats; D013116:Spinal Cord / Q000502:physiology
D004723:Endorphins; D004745:Enkephalins; D009270:Naloxone; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D006005:Phosphorylases