Effect of medrogestone on conversions of pregnenolone and 17 alpha-hydroxypregnenolone in rat testis.
Medrogestone, viz., 6,17-dimethylpregn-4,6-diene,3,20-dione (Colprone), a synthetic compound with progestational and antiandrogenic properties, was studied for its effects on the metabolism of pregnenolone and 17 alpha-hydroxypregnenolone by a 10,000 g supernatant fraction of testicular homogenates. This compound inhibited the conversion of pregnenolone to progesterone (91%), 17 alpha-hydroxyprogesterone (83%), delta 4-androstenedione (43%), and testosterone (30%) and the conversion of 17 alpha-hydroxypregnenolone to 17 alpha-hydroxyprogesterone (84%), delta 4-androstenedione (56%), and testosterone (38%).
D006907:17-alpha-Hydroxypregnenolone / Q000378:metabolism*; D000735:Androstenedione / Q000378:metabolism; D000818:Animals; D008297:Male; D008524:Medrogestone / Q000494:pharmacology*; D011245:Pregnadienes / Q000494:pharmacology*; D011284:Pregnenolone / Q000378:metabolism*; D011374:Progesterone / Q000378:metabolism; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism
D011245:Pregnadienes; D008524:Medrogestone; D006907:17-alpha-Hydroxypregnenolone; D013739:Testosterone; D000735:Androstenedione; D011374:Progesterone; D011284:Pregnenolone