Use of anticoagulants, electroencephalographic monitoring, and barbiturate cerebral protection in carotid endarterectomy.
This paper describes a treatment protocol for threatened stroke in patients to carotid endarterectomy. The protocol includes the use of perioperative anticoagulation, intraoperative electroencephalographic (EEG) monitoring, and hypertension or barbiturates to protect the brain against documented ischemia intraoperatively. The rational and methods for protecting the patient from the threat of thromboembolism and cerebral ischemia during each of the periods of specific risk are discussed. The most unique feature of this protocol is the use of thiopental-induced EEG burst suppression for ischemia unresponsive to hypertension during carotid clamping, which has obviated the use of a potentially dangerous and cumbersome in-line arterial shunt.
D001463:Barbiturates / Q000627:therapeutic use*; D002339:Carotid Arteries / Q000601:surgery*; D002561:Cerebrovascular Disorders / Q000503:physiopathology / Q000517:prevention & control*; D004569:Electroencephalography; D004691:Endarterectomy; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D007430:Intraoperative Care; D002546:Ischemic Attack, Transient / Q000503:physiopathology; D011182:Postoperative Care; D011300:Preoperative Care; D012306:Risk
D001463:Barbiturates; D006493:Heparin