Histiocytic lymphoma following resolution of sarcoidosis.
A 32-year-old female who developed respiratory symptoms and hilar and mediastinal lymph node enlargement had a biopsy of a mediastinal lymph node typical of sarcoidosis. The symptoms and lymphadenopathy resolved spontaneously without therapy. Eighteen months later the patient developed recurrent respiratory symptoms and a large anterior mediastinal mass, a biopsy of which showed a diffuse sclerosing histiocytic lymphoma, without evidence of sarcoidosis. The possibility of a common etiologic factor or transformation of sarcoidosis into a histiocytic lymphomas are discussed.
D000328:Adult; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006644:Histiocytes; D006801:Humans; D008223:Lymphoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D008479:Mediastinal Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging; D011241:Prednisone / Q000627:therapeutic use; D011859:Radiography; D012507:Sarcoidosis / Q000150:complications* / Q000000981:diagnostic imaging; D014750:Vincristine / Q000627:therapeutic use
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone