Effect of candicidin on cholesterol and bile acid metabolism in the rat.
Sterol metabolism studies were carried out in rats maintained on a diet containing a polyene antibiotic, candicidin, (30 mg/kg/day) for 2-1/2 months. Compared to the controls, the candicidin-treated animals had a smaller food intake and weight gain during this period. There was no difference between the 2 groups in serum cholesterol levels, biliary cholesterol or bile acid concentrations. However, in the experimental group, liver cholesterol content decreased by 27% and hepatic HMG-CoA reductase increased by 36%. Candicidin administration produced an 84% increase in neutral sterol output without change in bile acid output. Cholesterol absorption was reduced 80% by candicidin feeding. The weight of ventral prostate was reduced 33% by candicidin administration. Prostatic HMG-CoA reductase levels were 3 times higher than those of the liver, but enzyme activity was unchanged by candicidin treatment.
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001647:Bile Acids and Salts / Q000378:metabolism*; D002174:Candicidin / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D011467:Prostate / Q000033:anatomy & histology / Q000378:metabolism; D051381:Rats
D000935:Antifungal Agents; D001647:Bile Acids and Salts; D002174:Candicidin; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases