[Treatment of recurrent ulcer with cimetidine].
The most effective treatment of recurrent ulcer is re-operation, which is associated with high rates of mortality or complications, and of recurrences. Antacid treatment is disappointing. There are conflicting reports of the effect of cimetidine. We present a prospective study of 10 patients with recurrent ulcer treated with cimetidine, 1.0 g/day for six weeks, with endoscopic follow up. The ulcer healed in five after six weeks of treatment and in seven after 12 weeks, but recurred 2-8 months later. We conclude that cimetidine has a shortterm effect in recurrent ulcer and is indicated only in high risk patients.
D000328:Adult; D000368:Aged; D002927:Cimetidine / Q000627:therapeutic use*; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy; D011446:Prospective Studies; D012008:Recurrence; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000601:surgery
D006146:Guanidines; D002927:Cimetidine