Interactions between intracranial electrical self-stimulation behavior and cardiovascular responses.
Interactions between electrical self-stimulating behavior, cardiovascular state and reactions were studied in a series of chronically prepared cats. Pressor responses were found to be the most common cardiovascular concomitants of intracranial electrical self-stimulating behavior in cats. The lever-pressing rate for brain stimulation decreased under the effect of both dibenzyline, an adrenergic blocking agent, and local anesthesia of the cervical vago-sympathetic trunk by procaine. Bilateral vagotomy resulted in an acceleration in lever-pressing responses. The depression and the acceleration in the lever-pressing for brain stimulation were associated with an increase and a decrease in pulse pressure, respectively. It is suggested that peripheral autonomic modifications exert a regulatory feedback effect on the rewarding property of brain stimulation.
D000320:Adrenergic Fibers / Q000502:physiology; D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D002319:Cardiovascular System / Q000294:innervation*; D002415:Cats; D004558:Electric Stimulation; D005260:Female; D006439:Hemodynamics; D008297:Male; D012119:Respiration; D012653:Self Stimulation / Q000502:physiology*; D014630:Vagus Nerve / Q000502:physiology