Effect of alternating administration of PS-K and carbazilquinone in tumor-bearing mice.
In order to establish procedure for immunochemotherapy, the delayed hypersensitivity reaction (DHR) was investigated in tumor-bearing mice treated with an immunopotentiator, basidiomycetes polysaccharide (PS-K). DHR in the group given continuous administration of immunopotentiator was initially much stronger than that in the untreated group; however, the reactions were the same by the 4th week. The tumor-bearing group give intermittent administration of immunopotentiator retained strong DHR throughout the course, even though prolonged continuous administration failed to maintain such elevated immunoresponses. Alternating treatment with PS-K and carbazilquinone induced much higher DHR and much longer survival. The experimental results showed that continuous administration of an immunopotentiator led to decreasing immune responses in tumor-bearing mice. Intermittent administration of immunopotentiator was proved to be effective in restoring tumor suppression.
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D001389:Azirines / Q000008:administration & dosage*; D002225:Carbazilquinone / Q000008:administration & dosage* / Q000494:pharmacology; D006968:Hypersensitivity, Delayed / Q000139:chemically induced; D051379:Mice; D011509:Proteoglycans / Q000008:administration & dosage* / Q000494:pharmacology; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000276:immunology
D000276:Adjuvants, Immunologic; D000972:Antineoplastic Agents, Phytogenic; D001389:Azirines; D011509:Proteoglycans; D002225:Carbazilquinone; C010770:polysaccharide-K