[Prodigiozan as an activator of peritoneal macrophages].
The quantitative cytochemical investigation of the prodigiozan effect on the enzymatic activity of the peritoneal macrophages was performed on mice. The drug was administered in a single dose of 150 microgram/kg 24 hours before the specimen collection. Prodigiozan promoted a reliable increase in the activity of the enzymes participating in glycolysis (lactate and cytoplasmic alpha-glycerophosphate dehydrogenases), hexoso-monophosphatic pathway of glucose oxidation (glucoso-6-phosphate dehydrogenase), succinate dehydrogenase, NADP. N-diaphorase and lysosomal enzymes, such as acid phosphatase and non-specific alpha-naphthyl acetate esterase. The changes indicate that activation of the macrophages is one of the significant mechanisms of increasing the host nonspecific resistance with prodigiozan.
D000276:Adjuvants, Immunologic; D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology / Q000276:immunology*; D004789:Enzyme Activation / Q000187:drug effects; D006019:Glycolysis / Q000187:drug effects; D006651:Histocytochemistry; D007113:Immunity, Innate / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D011354:Prodigiozan / Q000276:immunology*
D000276:Adjuvants, Immunologic; D011135:Polysaccharides, Bacterial; D011354:Prodigiozan
Prodigiozan kak aktivator peritoneal'nykh makrofagov.