Microsomal injury in the liver of rats treated with carbon tetrachloride.
The oral administration of CCl4 (2.5 ml/kg) to male rats inducted increase in the activity of serum GPT, accumulation of hepatic triglyceride, acceleration of depression in the activities of microsomal enzymes, disaggregation of hepatic polyribosomes, and decrease in the ability of in vitro protein synthesis 0.5 hr after the intubation. When, however, a small dose of CCl4 (0.25 ml/kg) were given, the defects in hepatic polyribosomes and mixed-function oxygenase system were most marked among the above toxic changes.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology; D050356:Lipid Metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D011132:Polyribosomes / Q000187:drug effects; D011506:Proteins / Q000378:metabolism; D051381:Rats; D012270:Ribosomes / Q000201:enzymology
D008054:Lipid Peroxides; D011506:Proteins; D006899:Mixed Function Oxygenases; D000410:Alanine Transaminase