Multiple primary malignant neoplasia in three members of a family.
Three members of a family have presented in adult life with a succession of invasive malignancies. No known premalignant condition has been apparent in this group, and a limited study of immune competence has failed to reveal any abnormality. In spite of this there is strong evidence to suggest a so far undetected immunogenetic abnormality as the basis of this phenomenon.
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007121:Immunocompetence; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000276:immunology; D010375:Pedigree; D011379:Prognosis