Comparative analysis of specificity in protein-protein interactions. Part I.: A theoretical and mathematical approach to specificity in protein-protein interactions.
The definition of informational complementarity (IC) is introduced and a comparative computer method is described to analyse the possible sources of the specificity in some protein-protein (P-P) interactions. The essence of this method is the step-by-step comparison of the primary structures of the proteins regarding the frequency and sequence (distribution) of one or more selected amino acids. The calculation of the probability of finding two different amino acids in two different protein parts by the same frequency and distribution (Random Pair Building, RPB) and it's checking with the number of actually found pairs (Concrete Pair Building, CPB) and with the number of maximal available pair forming (Maximal Pair Building, MPB) may give the chance to find IC sequences and to understand the nature of specific P-P interactions. The usefulness of this method for analysing intramolecular structures and intermolecular interactions is discussed and an example is presented how it may be used.
D000595:Amino Acid Sequence; D003201:Computers; D006801:Humans; D007257:Information Theory; D008956:Models, Chemical; D010908:Pituitary Hormones, Anterior / Q000378:metabolism; D011487:Protein Conformation; D011506:Proteins / Q000378:metabolism*
D010908:Pituitary Hormones, Anterior; D011506:Proteins