Effect of prostaglandin E1, E2 or indomethacin on serum parathyroid hormone and calcitonin in the rat.
Infusion of 100 or 200 ng/min of Prostaglandin E1 (PGE1) or of 100 ng/min of PGE2 increased serum parathyroid hormone (PTH) in the rat. These infusions, however, had no significant effect on serum calcitonin (CT). Administration of 10 mg/kg of indomethacin for 3 days had no significant effect on basal serum PTH, CT or Calcium (Ca). EDTA infusion increased serum PTH to a similar degree in the vehicle- or indomethacin-treated rats. Therefore, endogenous prostaglandins do not appear to play a role in the secretion of PTH or CT.
D000818:Animals; D002116:Calcitonin / Q000097:blood*; D002118:Calcium / Q000097:blood; D006996:Hypocalcemia / Q000097:blood; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D010280:Parathyroid Glands / Q000601:surgery; D010281:Parathyroid Hormone / Q000097:blood*; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats; D013965:Thyroidectomy
D010281:Parathyroid Hormone; D011458:Prostaglandins E; D002116:Calcitonin; D002118:Calcium; D007213:Indomethacin