Altered red blood cell surface area in hereditary xerocytosis.
Hereditary xerocytes appear larger than normal red cells in scanning electron micrographs and exhibit a higher ghost packing volume. The major chemical components--protein, phosphorus, cholesterol and sialic acid--are increased uniformly, as are all polypeptides visible on gel electrophoresis patterns of xerocyte membranes. These data are consistent with a xerocyte surface area 15 to 25% above normal. Certain clinical anomalies common to this disorder, including unexpectedly low reticulocyte count and 2,3-diphosphoglycerate level, are discussed in the light of the present findings.
D002784:Cholesterol / Q000097:blood; D004905:Erythrocyte Aging; D004909:Erythrocyte Indices; D004910:Erythrocyte Membrane / Q000378:metabolism / Q000648:ultrastructure; D004913:Erythrocytes, Abnormal / Q000648:ultrastructure*; D005260:Female; D006402:Hematologic Diseases / Q000097:blood* / Q000235:genetics; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000097:blood; D010758:Phosphorus / Q000097:blood; D012794:Sialic Acids / Q000097:blood; D012795:Sialoglycoproteins / Q000097:blood
D008565:Membrane Proteins; D012794:Sialic Acids; D012795:Sialoglycoproteins; D010758:Phosphorus; D002784:Cholesterol