In vivo release of enkephalin from the globus pallidus.
Push-pull cannulae were acutely positioned through previously implanted guides in the globus pallidus of unanesthetized freely moving cats and rats. During slow-flow perfusions, enkephalin release was detected in resting conditions and increased more than 3-fold when both 50 mM K+ and 1.8 mM Ca2+ were present in the perfusing medium. Local perfusion with veratrine also enhanced enkephalin release. Furthermore, in vivo, electrical stimulation of the rat caudo-putamen enhanced enkephalin release in the pallidum. This latter finding is consistent with a functional strio-pallidal enkephalin-containing pathway previously postulated by immunohistochemical or lesion experiments.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002415:Cats; D004723:Endorphins / Q000378:metabolism*; D004745:Enkephalins / Q000378:metabolism*; D005917:Globus Pallidus / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D010477:Perfusion; D011188:Potassium / Q000494:pharmacology; D051381:Rats
D004723:Endorphins; D004745:Enkephalins; D011188:Potassium; D002118:Calcium