A new antitumor antibiotic, stubomycin.
A new antibiotic, stubomycin, was isolated from the culture broth and mycelia of Streptomyces strain No. KG-2245. Stubomycin was prepared as colorless plates and has the empirical formula C29H35NO5. The antibiotic possesses growth inhibitory activity against Gram-positive bacteria and transplantable murine tumors, such as Ehrlich carcinoma, and leukemia P388. The antibiotic also shows direct cytotoxic activity against HeLa cells in vitro.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells / Q000187:drug effects; D008297:Male; D051379:Mice; D008970:Molecular Weight; D011090:Polyenes / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000502:physiology
D000903:Antibiotics, Antineoplastic; D011090:Polyenes; C031780:stubomycin