Immunology of chronic gastritis.
65 patients with chronic gastritis and 12 controls with normal gastric mucosa were studied for cell-mediated immunity by the means of the lymphocyte blasttransformation and leukocyte migration inhibition tests. In these patients parietal cell antibodies were determined by the indirect immunofluorescence test as well. In 22 patients who had eigher isolated fundal gastritis, isolated antral gastritis or pangastritis cellular immune reactions to fundal or/and antral mucosal antigen extracts were revealed, whereas only 8 had parietal cell antibodies in their sera. It is suggested that for immunological characterization of chronic gastritis the evaluation of cellular immune reactions must be undertaken as well as antibody determinations.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000941:Antigens / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis; D001324:Autoantigens / Q000276:immunology*; D002464:Cell Migration Inhibition; D002908:Chronic Disease; D005260:Female; D005756:Gastritis / Q000276:immunology*; D005757:Gastritis, Atrophic / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged
D000941:Antigens; D001323:Autoantibodies; D001324:Autoantigens