[Effect of amantadine (1-aminoadamantane) and remantadine (alpha-methyl-1-adamantane methyl amine) hydrochlorides on formation of influenza A viral proteins].
Inhibitory effect of amantadine (I-amino adamantane) and remantadine (alpha-methyl-1-adamantane methylamine) hydrochlorides on reproduction of influenza A virus as well as, in particular, on formation of virus specific proteins was studied in cell culture. These drugs were dissimilar; they resembled each other in the patients of their effect as a function of the course of administration into the cells infected with the virus. Both preparations inhibited the synthesis of virus specific proteins exhibiting distinct effects under conditions of preliminary or immediate administration following the infection. At the same time, the inhibitory properties of remantadine were maintained at the subsequent period after infection; these were not observed in the amantadine treatment.
D000218:Adamantane / Q000031:analogs & derivatives*; D000547:Amantadine / Q000494:pharmacology*; D000818:Animals; D002642:Chick Embryo; D009980:Influenza A virus / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D012299:Rimantadine / Q000494:pharmacology*; D014764:Viral Proteins / Q000096:biosynthesis*; D014779:Virus Replication / Q000187:drug effects
D014764:Viral Proteins; D012299:Rimantadine; D000547:Amantadine; D000218:Adamantane
Sravnitel'noe izuchenie deĭstviia solianokislykh amantadina (1-aminoadamantana) i remantadina (al'fa-metil-1-adamantanmetilamina) na obrazovanie belkov virusa grippa A.