[Effect of the long-term administration of testosterone on induction of cytochrome P-450 in female rat live tissue using phenobarbital].
A preadministration of testosterone propionate into rat females within 8 days caused an increase in the inducing effect of phenobarbital (after its single injection) on the content of cytochrome P-450 in liver tissue. The administration of testosterone did not affect the content of the enzyme in liver tissue. A shown in the experiments on phenobarbital induction of the enzyme as a function of duration of testosterone administration, two maximal peaks, within 1 and 8 days, were observed after preadministration of the hormone. The hormone influenced mainly on the rate of the increase in cytochrome P-450 content but not on degree of its induction.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004790:Enzyme Induction; D005260:Female; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital
Vliianie prodolzhitel'nosti vvedeniia testosterona na induktsiiu tsitokhroma P-450 v pecheni samok krys fenobarbitalom.