Studies on isolation of a toxic substance from human and animal skin burned in vitro.
Attempts to obtain burn toxin from animal and human skin are reported. Mouse skin was burned with a metal stamp by the method of Allgöwer. The human and the skin of various experimental animals was scalded in NaCl solution by the method of Rosenthal. Using the latter method it was possible to obtain the so-called "crude burn toxin" from the human skin. It was highly lethal to mice, rats, rabbits and guinea pigs after toxic. No toxic preparations were obtained from the skin of various experimental animals using the method of burning and processing described by Rosenthal.
D000293:Adolescent; D000328:Adult; D000818:Animals; D002056:Burns; D002521:Cercopithecus; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008875:Middle Aged; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000032:analysis*; D013552:Swine; D014020:Tissue Extracts / Q000032:analysis*; D014118:Toxins, Biological / Q000302:isolation & purification* / Q000633:toxicity
D014020:Tissue Extracts; D014118:Toxins, Biological