[Quantitative ultrastructural, cytochemical, and functional characteristics of rat gastric parietal cells following administration of hydrocortisone and testosterone propionate].
In the experiment performed on white rats (males), microscopical and histochemical investigations with successive morpho- and cytological studies have demonstrated that injections of large doses of hydrocortisone (unlike the small ones) produce certain distrophic changes in the parietal cells, demonstrated as a decrease in the secretory membranes, mitochondrial destruction, discoordination of the energy metabolism and a sharp drop of the acid-producing function. Testosterone injection produces an opposite effect on the parietal cells. When the preparations are injected simultaneously, testosterone, while increasing resistivity and threshold sensitivity of the parietal cells to hydrocortisone, decreases destructive effect of the latter.
D000818:Animals; D004347:Drug Interactions; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D006651:Histocytochemistry; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D006854:Hydrocortisone
Kolichestvennaia ul'trastrukturnaia, tsitokhimicheskaia i funktsional'naia kharakteristika obkladochnykh kletok zheludka u krys pri vvedenii gidrokortizona i testosteron propionata.