Inhibition of hepatic cholesterol biosynthesis by chloroquine.
Chloroquine is shown to be a potent inhibitor of cholesterol biosynthesis by isolated rat hepatocytes. Half-maximal inhibition of cholesterogenesis occurs at ca. 10 micro M chloroquine. Chloroquine does not affect fatty acid synthesis by isolated hepatocytes. This suggests that chloroquine acts on the cholesterol biosynthetic pathway beyond the cytosolic acetyl-coA branchpoint of cholesterol and fatty acid synthesis.
D000818:Animals; D000924:Anticholesteremic Agents; D002738:Chloroquine / Q000494:pharmacology*; D002784:Cholesterol / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids / Q000096:biosynthesis; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008297:Male; D051381:Rats
D000924:Anticholesteremic Agents; D005227:Fatty Acids; D002738:Chloroquine; D002784:Cholesterol