Cimetidine protects against acetaminophen hepatotoxicity in rats.
D000082:Acetaminophen / Q000506:poisoning*; D000410:Alanine Transaminase / Q000097:blood; D000632:Aminopyrine / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D002927:Cimetidine / Q000627:therapeutic use*; D005978:Glutathione / Q000378:metabolism; D006146:Guanidines / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008107:Liver Diseases / Q000188:drug therapy; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009336:Necrosis; D051381:Rats; D011916:Rats, Inbred F344
D006146:Guanidines; D000632:Aminopyrine; D000082:Acetaminophen; D002927:Cimetidine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione