Comparison of induction of sister chromatid exchange, 8-azaguanine- and ouabain-resistant mutants by cyclophosphamide, ifosfamide and 1-(pyridyl-3)-3,3-dimethyltriazene in Chinese hamster cells cultured in diffusion chambers in mice.
Data on induction of sister chromatid exchange (SCE), 8-azaguanine and ouabain-resistant mutants in V79 cells in diffusion chambers in mice treated with three chemicals were compared to determine the relationship between SCE and mutation. For 1-(pyridyl-3)-3,3-dimethyltriazene, a positive, linear correlation was demonstrated between induced SCE and mutation at both loci. For cyclophosphamide and ifosfamide, it was observed that SCE analysis was a more sensitive biological endpoint than induction of mutation.
D000818:Animals; D001375:Azaguanine / Q000494:pharmacology; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D003434:Crossing Over, Genetic / Q000187:drug effects*; D003520:Cyclophosphamide / Q000494:pharmacology; D004351:Drug Resistance; D007069:Ifosfamide / Q000494:pharmacology; D051379:Mice; D009153:Mutagens / Q000494:pharmacology; D009154:Mutation; D010042:Ouabain / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D014226:Triazenes / Q000494:pharmacology
D009153:Mutagens; D011725:Pyridines; D014226:Triazenes; C009126:1-(3-pyridyl)-3,3-dimethyltriazene; D010042:Ouabain; D003520:Cyclophosphamide; D001375:Azaguanine; D007069:Ifosfamide