Plasma lecithin: cholesterol acyltransferase in copper-deficient rats.
Some groups of people with high risk of ischemic heart disease have low lecithin:cholesterol acyltransferase activity in plasma and vice versa. Because we hypothesized a relationship between inadequate copper nutriture and the risk of ischemic heart disease, we measured plasma lecithin: cholesterol acyltransferase in copper deficient male Sprague-Dawley rats. Deficiency was verified by the presence of anemia, hypercholesterolemia and low copper concentrations in kidney and skeletal muscle. Three experiments showed a significant decrease (22-32% reduction) in enzyme activity in deficiency. Copper may be required for the synthesis of the enzyme or as a constituent of the enzyme.
D000818:Animals; D002784:Cholesterol / Q000097:blood; D003300:Copper / Q000172:deficiency*; D003327:Coronary Disease / Q000209:etiology*; D006400:Hematocrit; D007668:Kidney / Q000032:analysis; D008297:Male; D009132:Muscles / Q000032:analysis; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000032:analysis
D003300:Copper; D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D015032:Zinc