[Reversible amytal-induced depolarization of perfused rat liver cell membranes].
Prompt, completely reversible and deep (to 75%) depolarisation was obtained in perfused rat liver, treated wih amobarbital sodium to 10 mM. Kinetically the main effect developed in a relatively narrow concentration interval 3-4 mM. Administration of amobarbital in 12-15 mM may produce a progressive reduction of membrane potentials to null and positive values followed by a loss of reversibility. One of the possibilities deduced was that of amobarbital unique ability to induce cooperative-like membraneous "conservation", enabling the cells to support their ionic gradients in spite of severe metabolic inhibition.
D000654:Amobarbital / Q000494:pharmacology*; D000818:Animals; D008099:Liver / Q000187:drug effects*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D010477:Perfusion; D051381:Rats
D000654:Amobarbital
Obratimaia amital-indutsirovannaia depoliarizatsiia membran kletok perfuziruemoĭ pecheni krys.