Rejection of the intestinal parasite Nippostrongylus brasiliensis by mast cell-deficient W/Wv anemic mice.
The ability of W/Wv anemic mice to accumulate mucosal mast cells and to reject the intestinal parasite Nippostrongylus brasiliensis was examined. W/Wv mice did not accumulate mucosal mast cells in response to infections with N. brasiliensis. They eliminated a primary infection more slowly than did their normal littermate controls but were as refractory as controls to second and third infections. W/Wv mice had higher serum titers of worm-specific immunoglobulin E than did controls. These results indicate that mucosal mast cells are not an absolute requirement for N. brasiliensis rejection.
D000818:Animals; D007073:Immunoglobulin E / Q000032:analysis; D007413:Intestinal Mucosa / Q000473:pathology; D007422:Intestines / Q000469:parasitology; D008407:Mast Cells / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009349:Nematode Infections / Q000276:immunology* / Q000469:parasitology; D009559:Nippostrongylus / Q000254:growth & development; D010270:Parasite Egg Count
D007073:Immunoglobulin E