Cholesterol excretion and colon cancer.
Populations consuming diets high in fat and cholesterol exhibit a greater incidence of colon cancer than those consuming less fat and cholesterol. Lowering elevated serum cholesterol levels experimentally or clinically is associated with increased large-bowel tumorigenesis. Thus, cholesterol lost to the gut, either dietary or endogenously synthesized, appears to have a role in large-bowel cancer. Whether the effect(s) is mediated by increases in fecal bile acid excretion or some other mechanism is not clear.
D001647:Bile Acids and Salts / Q000008:administration & dosage / Q000378:metabolism; D002784:Cholesterol / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D002791:Cholesterol, Dietary / Q000009:adverse effects; D003110:Colonic Neoplasms / Q000209:etiology*; D003327:Coronary Disease / Q000209:etiology; D004032:Diet / Q000009:adverse effects; D004041:Dietary Fats / Q000009:adverse effects; D005243:Feces; D006801:Humans
D001647:Bile Acids and Salts; D002791:Cholesterol, Dietary; D004041:Dietary Fats; D002784:Cholesterol