Inhibition by warfarin enantiomers of prothrombin synthesis, protein carboxylation, and the regeneration of vitamin K from vitamin K epoxide.
D000818:Animals; D002625:Chemistry, Organic; D003864:Depression, Chemical; D004852:Epoxy Compounds / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D055601:Organic Chemistry Phenomena; D011506:Proteins / Q000378:metabolism*; D011516:Prothrombin / Q000096:biosynthesis*; D051381:Rats; D013237:Stereoisomerism; D014812:Vitamin K / Q000378:metabolism*; D010837:Vitamin K 1 / Q000031:analogs & derivatives / Q000378:metabolism; D014859:Warfarin / Q000494:pharmacology*
D004852:Epoxy Compounds; D011506:Proteins; D014812:Vitamin K; C016186:vitamin K1 oxide; D014859:Warfarin; D010837:Vitamin K 1; D011516:Prothrombin