[Effect of the sympatholytic pirroxan on catecholamine excretion in experimental tetanus].
Excretion of catecholamines and vanilylmandelic acid was studied in rabbits with tetanic intoxication. It was found that catecholamine excretion increases up to 173% in the initial stages of the disease and falls to 51% at the height of the disease whereas excretion of vanilylmandelic acid progressively decreases down to 40% against normal. Pirroxan (10 mg/kg a day) reduces excretion of catecholamines and vanilylmandelic acid by three times, concurrently producing a definite cholinolytic effect.
D000818:Animals; D002395:Catecholamines / Q000652:urine*; D004146:Dioxanes / Q000627:therapeutic use*; D004147:Dioxins / Q000627:therapeutic use*; D004231:Diuresis; D011759:Pyrrolidines / Q000627:therapeutic use; D011817:Rabbits; D013742:Tetanus / Q000188:drug therapy* / Q000652:urine; D014642:Vanilmandelic Acid / Q000652:urine*
D002395:Catecholamines; D004146:Dioxanes; D004147:Dioxins; D011759:Pyrrolidines; D014642:Vanilmandelic Acid; C009143:proroxan
Vliianie simpatolitika pirroksana na ékskretsiiu katekholaminov pri éksperimental'noĭ stolbniachnoĭ intoksikatsii.