Zinc acetate as a precipitant of unstable haemoglobins.
Whereas the addition of four moles of zinc acetate to one of normal human haemoglobin at pH 7.4 results in a clear solution, addition to unstable haemoglobin results in precipitate formation. Within certain limits no false-positive results are obtained with methaemoglobin, and with fetal haemoglobin. With excess zinc, normal haemoglobin also precipitates, but this process is reversible and can be used for a rapid concentration of dilute solutions of normal haemoglobin.
D000085:Acetates; D019342:Acetic Acid; D011232:Chemical Precipitation; D006454:Hemoglobins; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015032:Zinc
D000085:Acetates; D006454:Hemoglobins; D015032:Zinc; D019342:Acetic Acid