Mitotic and meiotic analysis of a reciprocal translocation t(Y;3) in an azoospermic male.
A balanced reciprocal translocation t(Y;3)(q11.2q12) is detected in an azoospermic male, with a normal phenotype. Replication study shows no modification of the replication pattern of the bands of the rearranged chromosomes. Meiotic studies show a chain element at diakinesis. At the pachytene stage, the Y-body is in external contact with the sex vesicle. It is concluded that the integrity of the Y-chromosome is probably necessary for a normal meiotic process, and is more important than dosage effect due to complete or partial disomy of this chromosome.
D000328:Adult; D002478:Cells, Cultured; D002871:Chromosome Banding; D002900:Chromosomes, Human, 1-3; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D008540:Meiosis; D008938:Mitosis; D009845:Oligospermia / Q000235:genetics* / Q000503:physiopathology; D012730:Sex Chromosomes; D014178:Translocation, Genetic; D014998:Y Chromosome