Hyperthermia-induced seizures in the rat pup: a model for febrile convulsions in children.
Seizures were produced in rat pups by ambient hyperthermia. Seizure threshold temperatures, measured rectally and intracerebrally, increased between 2 and 10 days of age. Electrocortical paroxysmal discharges were confirmed in hyperthermic 6- and 10-day-old pups. The increasing resistance to hyperthermic seizures with maturation and the electroencephalographic changes induced by hyperthermia are similar to those in young children.
D000367:Age Factors; D000818:Animals; D001921:Brain / Q000503:physiopathology; D004195:Disease Models, Animal; D004569:Electroencephalography; D005334:Fever / Q000150:complications*; D051381:Rats; D012640:Seizures / Q000503:physiopathology*; D003294:Seizures, Febrile / Q000503:physiopathology*