[Correction of hypersensitivity to strophanthin in experimental myocardial infarction by pharmacologic effects on extracardiac innervation].
Experiments on 176 cats with experimental myocardial infarction were made to study alterations in ouabain tolerance under pharmacological effects on extracardial innervation. It was shown that elimination of sympathetic innervation at different levels by benzohexonium, ornid and anapriline, as well as its relative weakening by proserine favoured the correction of hypersensitivity to ouabain in acute myocardial ischemia. Potentiation of sympatic effects by ephedrine and abolition of parasympathetic innervation by atropine increased ouabain cardiotoxicity.
D000818:Animals; D001285:Atropine / Q000008:administration & dosage; D001950:Bretylium Tosylate / Q000008:administration & dosage; D002415:Cats; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D004809:Ephedrine / Q000008:administration & dosage; D005260:Female; D006584:Hexamethonium Compounds / Q000008:administration & dosage; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy*; D009388:Neostigmine / Q000008:administration & dosage; D011433:Propranolol / Q000008:administration & dosage; D013328:Strophanthins / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D013565:Sympatholytics / Q000008:administration & dosage*
D006584:Hexamethonium Compounds; D013328:Strophanthins; D013565:Sympatholytics; D009388:Neostigmine; D001950:Bretylium Tosylate; D001285:Atropine; D011433:Propranolol; D004809:Ephedrine; C021628:benzohexonium
Korrektsiia giperchuvstvitel'nosti k strofantinu pri éksperimental'nom infarkte miokarda farmakologicheskimi vozdeĭstviiami na ékstrakardial'nuiu innervatsiiu.