Isoprenoid biosynthesis in adult Brugia pahangi and Dirofilaria immitis.
The ability of adult B. pahangi and D. immitis to utilize [14C]-mevalonate for the biosynthesis of isoprenoid compounds was investigated. Both filariae appeared to be unable to synthesize squalene and sterols de novo. They did, however, synthesize ubiquinone 9, a family of dolichol isoprenologs, and predominantly, the short-chain isoprenoid alcohol, geranyl geraniol. In addition, B. pahangi and D. immitis apparently were unable to synthesize a menaquinone (Vitamin K2) from [14C]-menadione.
D000818:Animals; D002009:Brugia / Q000378:metabolism*; D002784:Cholesterol / Q000096:biosynthesis; D004183:Dirofilaria immitis / Q000378:metabolism*; D004224:Diterpenes / Q000096:biosynthesis; D004286:Dolichols / Q000096:biosynthesis; D005260:Female; D005370:Filarioidea / Q000378:metabolism*; D008297:Male; D008798:Mevalonic Acid / Q000378:metabolism; D010168:Palmitates / Q000096:biosynthesis; D013729:Terpenes / Q000096:biosynthesis*; D014451:Ubiquinone / Q000096:biosynthesis; D014812:Vitamin K / Q000096:biosynthesis
D004224:Diterpenes; D004286:Dolichols; D010168:Palmitates; D013729:Terpenes; D014812:Vitamin K; D014451:Ubiquinone; C029475:octadecyl palmitate; D002784:Cholesterol; C017338:geranylgeraniol; D008798:Mevalonic Acid