title: Alkali ion transport of primycin modified erythrocytes.
abstract: The effects of the antibiotic primycin on alkali cation transport of human erythrocytes were investigated. Primycin selectively increases the permeability of erythrocytes to alkali-cations according to the sequence: Cs+ greater than Rb+ approximately K+ greater than Na+. The time course of the cation effluxes depends on the antibiotic concentration and can be altered by negatively charged SDS. Some evidence is given for the mechanism of primycin-membrane interaction.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001693:Biological Transport, Active / Q000187:drug effects*; D002414:Cations, Monovalent; D002463:Cell Membrane Permeability / Q000187:drug effects; D002586:Cesium / Q000097:blood; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D007783:Lactones / Q000494:pharmacology; D018942:Macrolides; D011188:Potassium / Q000097:blood; D012413:Rubidium / Q000097:blood; D012964:Sodium / Q000097:blood; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D002414:Cations, Monovalent; D007783:Lactones; D018942:Macrolides; D002586:Cesium; D012967:Sodium Dodecyl Sulfate; D012964:Sodium; C009041:primycin; D012413:Rubidium; D011188:Potassium