Pharmacokinetic evaluation of noreximide in rats.
The pharmacokinetics of noreximide in the rat after i.v., p.o., and i.p. administration was studied. The biologic half-life of approximately 8 h was found almost the same for all three routes. Upon p.o. administration the fraction of drug absorbed is 85 per cent, and the peak concentration in the blood is reached within approximately 4.5 h. Addition pharmacokinetic parameters are listed.
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D006207:Half-Life; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D009636:Norbornanes / Q000008:administration & dosage / Q000378:metabolism*; D011619:Psychotropic Drugs / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D009636:Norbornanes; D011619:Psychotropic Drugs; C032550:noreximide