[Heterogeneity of cardiac glucocorticoid receptors].
The work presents the main results obtained in the investigation of properties and distribution of the glucocorticoid cardiac receptors as well as mutual conversions of different forms of the glucocorticoid-receptor complexes. The receptors have been found in hearts of various kinds of animals. The glucocorticoid receptor activity is distributed approximately evenly in the myocardium of the left and right ventricles and auricles. The receptors have been found both in isolated myocytes and in endothelium cells. Methods of chromatography can successfully be used in decomposition of the glucocorticoid-receptor complex to heterogenic components. The role of some factors in the mechanism of the functioning of the receptor system is discussed.
D000818:Animals; D002852:Chromatography, Ion Exchange; D003600:Cytosol / Q000378:metabolism; D005938:Glucocorticoids / Q000378:metabolism*; D066298:In Vitro Techniques; D009206:Myocardium / Q000378:metabolism*; D011485:Protein Binding; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000302:isolation & purification / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000378:metabolism
D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D013438:Sulfhydryl Compounds
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