title: [Effect of mebikar on the experimental and clinical course of traumatic shock].
abstract: The effect of mebikar upon the course of traumatic shock was studied on the basis of experimental investigations and clinical observations. The authors have found a positive effect of the drug on indices of acid-base state, histostructure and cellular composition of the liver whose disturbance has a great pathogenetic significance in shock. The application of mebikar considerably improved the results of treatment in clinic and reduced lethality in experiment. It was supposed that the positive effect of the drug was associated with prevention of the development of circulatory disorders and with the maintenance of oxidation-reduction process and the histostructure of tissues.
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects; D000328:Adult; D000818:Animals; D001736:Biureas / Q000627:therapeutic use*; D001643:Bridged Bicyclo Compounds / Q000627:therapeutic use*; D001952:Bridged-Ring Compounds / Q000627:therapeutic use*; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D051381:Rats; D012774:Shock, Traumatic / Q000188:drug therapy*; D014149:Tranquilizing Agents / Q000627:therapeutic use*
chemical_list: D001736:Biureas; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D014149:Tranquilizing Agents; C015979:mebikar
vernacular_title: Vliianie mebikara na techenie travmaticheskogo shoka v éksperimente i klinike.