Haematological factors associated with proliferative retinopathy in sickle cell-haemoglobin C disease.
In a selected sample of patients with sickle cell-haemoglobin C (SC) disease, proliferative retinopathy (PSR) occurred in 90/243 (37%) patients, developed most frequently between the ages of 20 and 30 years, and affected 68% patients aged 45 years or over. Comparison of haematological indices in patients with and without PSR, after age-related effects were allowed for, indicated significant relationships with high mean cell volume in males and with low fetal haemoglobin in both sexes. A highly significant relationship with total haemoglobin level in males (as previously reported in SS disease) was shown in SC disease to be entirely secondary to a strong age-related trend in haemoglobin level.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000755:Anemia, Sickle Cell / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D004909:Erythrocyte Indices; D005260:Female; D006445:Hemoglobin C Disease / Q000097:blood / Q000150:complications*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012164:Retinal Diseases / Q000097:blood / Q000209:etiology*; D012805:Sickle Cell Trait / Q000097:blood / Q000150:complications*
D006454:Hemoglobins