[Intracellular calcium redistribution in the thrombocytes during aggregation and release reaction].
With the aid of an original installation there was simultaneously measured aggregation, reaction of release of adenine nucleotides, and redistribution of calcium (by fluorescence of calcium-sensitive probe of chlortetracyclin) in one sample of the suspension of washed platelets of rabbit. For the first time there was found an increase in the intensity of fluorescence in the presence of ADP-induced aggregation which continued long after the platelets desaggregation. The obtained results suggest that this increase indicating the redistribution of calcium ions in cells, is associated with the refractory state of the platelets.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D002118:Calcium / Q000097:blood*; D002751:Chlortetracycline / Q000494:pharmacology; D005453:Fluorescence; D008156:Luciferases / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D013535:Suspensions; D013917:Thrombin / Q000494:pharmacology; D014466:Ultraviolet Rays
D013535:Suspensions; D000244:Adenosine Diphosphate; D008156:Luciferases; D013917:Thrombin; D002118:Calcium; D002751:Chlortetracycline
Issledovanie pereraspredeleniia vnutrikletochnogo kal'tsiia v trombotsitakh v protsesse agregatsii i reaktsii vysvobozhdeniia.