Interstitial fluid concentrations of cefsulodin, azlocillin and carbenicillin.
Cefsulodin, azlocillin and carbenicillin were administered by intramuscular injection to rats in a dose of 100 mg/kg. THe serum concentration in frequent samples after administration was determined and compared with the interstitial fluid (IF) concentration, measured with implanted paper discs enveloped in a dialysis tube. The IF concentration of cefsulodin was significantly higher than that of the other two antibiotics. The AUC in the IF was also larger for cefsulodin.
D000818:Animals; D001390:Azlocillin; D001826:Body Fluids / Q000378:metabolism; D002228:Carbenicillin / Q000378:metabolism*; D002441:Cefsulodin; D002511:Cephalosporins / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism; D010406:Penicillins / Q000378:metabolism*; D011485:Protein Binding; D051381:Rats; D013997:Time Factors
D002511:Cephalosporins; D010406:Penicillins; D002228:Carbenicillin; D001390:Azlocillin; D002441:Cefsulodin