The influence of splenic tissue implantation upon platelet population in rabbits after splenectomy.
An investigation of the behavior of the blood platelet population following splenectomy and autologous splenic tissue implantation has been done on the rabbit. A bimodal rise in platelet size and count is observed in the postoperative period. After splenectomy, a 722 per cent increase in the platelet count and a 21.9 percent rise in the platelet size are found. These increases are abolished by the implantation of splenic tissue. The existence of a splenic humoral factor that controls platelet production in the bone marrow is possible.
D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D001853:Bone Marrow / Q000502:physiology; D008099:Liver / Q000502:physiology; D010976:Platelet Count; D011817:Rabbits; D013154:Spleen / Q000502:physiology / Q000637:transplantation*; D013156:Splenectomy; D013922:Thrombocytosis / Q000209:etiology