Lecithin:cholesterol acyltransferase and serum fatty acids.
The rate of cholesterol esterification in vitro was significantly lower (-20%) in non-obese diabetics than in non-obese controls. More specifically, this decrease was found to be in cholesteryl linoleate synthesis. The concentration of serum free fatty acid, particularly of oleic acid, was 2-3 times higher in diabetic patients than in controls. The decreased rate of serum cholesterol esterification was associated with an increase in serum free fatty acid concentration and with a decrease of linoleic acid in serum phospholipids.
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D002849:Chromatography, Gas; D003920:Diabetes Mellitus / Q000097:blood*; D004951:Esterification; D005227:Fatty Acids / Q000097:blood*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood*
D001786:Blood Glucose; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase