[Immunosuppressant effect of cyclophosphamide activated in vitro by liver microsomes from different strains of mice].
The paper is concerned with activation of cyclophosphamide by mouse liver microsomes in vitro. Liver microsomes from BALB/c mice metabolize cyclophosphamide more effectively as compared with those from DBA/2 mice, which manifested by a more intense output of products having alkylating or immunodepressant properties. This seems likely to be a consequence of the increased P-450 cytochrome content in liver microsomes from BALB/c mice, as well as of its structural characteristics in the mouse. The relationship between the immunodepressant effect of cyclophosphamide in vivo and in vitro in mice of varied genotypes is discussed.
D000818:Animals; D001711:Biotransformation; D003520:Cyclophosphamide / Q000378:metabolism* / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D007166:Immunosuppressive Agents; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D008862:Microsomes, Liver / Q000032:analysis / Q000378:metabolism*; D013045:Species Specificity
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D003577:Cytochrome P-450 Enzyme System
Immunodepressivnyĭ éffekt tsiklofosfamida, aktivirovannogo in vitro mikrosomami pecheni mysheĭ raznykh liniĭ.