Tooth sizes in two males with deletions of the long arm of the Y-chromosome.
Permanent and deciduous tooth crown sizes in two males with deletions of the long arm of the Y chromosome and their first-degree relatives were examined. The first proband with a deletion in the proximal part of Yq11 showed definitely smaller teeth than his father or population control males. The second proband with a deletion in the distal part of Yq11 showed large or normal sized teeth compared to his brother or population control males. These data support the results of earlier studies indicating a promoting effect of the Y chromosome on tooth growth, and suggest that the location of the growth-promoting gene(s) is in Yq11. It is postulated that statural growth is affected by the same gene(s).
D000328:Adult; D002648:Child; D002872:Chromosome Deletion; D006801:Humans; D008297:Male; D009811:Odontometry; D012730:Sex Chromosomes; D014070:Tooth / Q000033:anatomy & histology*; D014998:Y Chromosome