title: Neuropharmacological actions of some newly synthesized Mannich bases.
abstract: Benzamido (alkyl) methyl pyrrolidine Mannich bases were synthetized and subjected to certain neuropharmacological studies. All the bases reduced the pentobarbitone sleeping time and rota-rod grip of rats. The Mannich bases II, III and V raised the minimal electro-shock seizure threshold of rats. The TAB-induced pyrexia was not reduced by the bases I and III in rabbits. None of the bases showed any significant analgesic activity.
mesh_terms: D000588:Amines / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008352:Mannich Bases / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology; D004856:Postural Balance / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D011955:Receptors, Drug / Q000378:metabolism*; D012684:Sensory Thresholds / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
chemical_list: D000588:Amines; D008352:Mannich Bases; D011955:Receptors, Drug; D010424:Pentobarbital