Biological studies of lipophilic MDP-derivatives incorporated in liposomes.
Adjuvant activities of fatty acid derivatives of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) in saline, emulsified in Incomplete Freund Adjuvant (IFA) or incorporated in liposomes were compared. All derivatives were active when given in saline. The potency of MDP-L-Ala-glycerol mycolate was highly enhanced by administration in IFA of after incorporation in liposomes. These procedures had no effect on the activity of MDP-alpha-methyl-gamma-eta-butyl ester and MDP-alpha-methyl-gamma-eta-decyl ester although the presence of MDP could be demonstrated at the surface of the liposomes by anti-MDP antibodies.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000276:immunology*; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000008:administration & dosage; D001666:Binding Sites, Antibody; D001667:Binding, Competitive; D002417:Cattle; D005227:Fatty Acids / Q000276:immunology*; D006020:Glycopeptides / Q000276:immunology*; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008081:Liposomes / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D012710:Serum Albumin, Bovine / Q000276:immunology; D012756:Sheep
D000276:Adjuvants, Immunologic; D000941:Antigens; D005227:Fatty Acids; D006020:Glycopeptides; D008081:Liposomes; D012710:Serum Albumin, Bovine; D000119:Acetylmuramyl-Alanyl-Isoglutamine