title: The histochemical localization of GABA-transaminase in the efferents of the striatum.
abstract: The striatum is known to contain GABA neurons projecting to the globus pallidus, entopeduncular nucleus and substantia nigra. Following lesions of striatal neurons with kainic acid, we have observed a decrease in the histochemically detectable activity of GABA-transaminase, the enzyme responsible for GABA catabolism, in both the striatum and in those areas to which it is known to send GABA projections. These results suggest that GABA-transaminase may be contained in striatal GABA neurons and thus that GABA-transaminase histochemistry may be a useful adjunct to the biochemical demonstration of GABA pathways in the brain.
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000032:analysis*; D000818:Animals; D001921:Brain / Q000187:drug effects; D003342:Corpus Striatum / Q000201:enzymology*; D004525:Efferent Pathways / Q000201:enzymology*; D005917:Globus Pallidus / Q000201:enzymology; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000201:enzymology; D000637:Transaminases / Q000032:analysis*
chemical_list: D000637:Transaminases; D000612:4-Aminobutyrate Transaminase; D007608:Kainic Acid