Testosterone, dihydrotestosterone, and zinc concentrations in human testis and epididymis.
Tissue testosterone, dihydrotestosterone, and zinc concentrations have been determined in testis and epididymis of 13 patients with carcinoma of the prostate, 1 patient with carcinoma of the penis, and 3 patients with carcinoma of the prostate on estrogens. The 13 patients not receiving estrogens had the following testicular levels: testosterone, of 529 +/- 63.1 ng/g (mean +/- SE); dihydrotestosterone, 23.7 +/- 2.58 ng/g; and zinc 62.2 +/- 7.6 micrograms/g. The epididymal levels were as follows: testosterone, 40.6 +/- 3.4 ng/g; dihydrotestosterone, 20.5 +/- 2.36 ng/g; and zinc, 67.2 +/- 11.1 micrograms/g. Patients on estrogen therapy showed much lower androgen values in the two organs but zinc was not changed significantly. Concentrations of androgens were not significantly different in the epididymal fractions of caput, corpus, and cauda. In testis, there was a positive correlation between zinc and androgens contents, while the opposite was suggested by the data in the epididymis. Even though these patients were not normal, there was no evidence of testicular or epididymal disturbances.
D000368:Aged; D013196:Dihydrotestosterone / Q000032:analysis*; D004822:Epididymis / Q000032:analysis*; D004967:Estrogens / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010412:Penile Neoplasms / Q000032:analysis; D011471:Prostatic Neoplasms / Q000032:analysis / Q000188:drug therapy; D013737:Testis / Q000032:analysis*; D013739:Testosterone / Q000032:analysis*; D015032:Zinc / Q000032:analysis*
D004967:Estrogens; D013196:Dihydrotestosterone; D013739:Testosterone; D015032:Zinc