Cholinergic urticaria with associated angio-oedema.
Three patients are described who developed angio-oedema and urticaria after a hot bath challenge and physical exercise. In one patient this was accompanied by a fall in peak expiratory flow rate. Blood levels of smooth muscle biological activity, measured using a bio-assay, increased in all patients after experimental challenge. The association of angio-oedema with cholinergic urticaria is emphasized and possible mechanisms discussed.
D000293:Adolescent; D000328:Adult; D000799:Angioedema / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D002799:Cholinergic Fibers / Q000503:physiopathology; D005260:Female; D006632:Histamine / Q000097:blood; D006358:Hot Temperature / Q000009:adverse effects; D006801:Humans; D008297:Male; D010366:Peak Expiratory Flow Rate; D005082:Physical Exertion; D014581:Urticaria / Q000097:blood / Q000209:etiology* / Q000503:physiopathology
D006632:Histamine