Development of sarcomas in heterotopically transplanted rat urinary bladder unit exposed to glucuronic acid conjugate of N-hydroxy-4-aminobiphenyl.
The glucuronic acid conjugate of N-hydroxy-4-aminobiphenyl was tested for carcinogenicity using a heterotopically transplanted rat urinary bladder (HTB) diverted from urine flow. A low-grade transitional cell carcinoma developed in 1 of 16 HTB and sarcoma surrounding the Ommaya reservoir connected to HTB in 8 of 16 rats. This unexpected high incidence of sarcomas, not previously observed in HTB-carcinogenesis model, suggested that the glucuronide conjugate of N-hydroxy-4-aminobiphenyl is a locally active carcinogen to mesenchymal cells.
D000611:Aminobiphenyl Compounds / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D005965:Glucuronates / Q000633:toxicity; D008297:Male; D051381:Rats; D012513:Sarcoma, Experimental / Q000139:chemically induced*; D001743:Urinary Bladder / Q000637:transplantation; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
D000611:Aminobiphenyl Compounds; D002273:Carcinogens; D005965:Glucuronates; C006757:4-biphenylamine; C014593:N-hydroxy-4-aminobiphenyl