Ledacrine effect on free fatty acids and glycerol mobilization from rat adipose tissue in vivo.
In rats receiving intraperitoneally Ledacrine in toxic doses the free fatty acids (FFA) and glycerol serum levels and the amount of fatty acids and glycerol released from the epididymal tissue of the rats were determined during one-hour incubation in vitro. It was found that Ledacrine in toxic doses stimulated the process of lipolysis as evidenced by raised serum FFA and glycerol levels and increased amount of FFA and glycerol released from the epididymal adipose tissue in vitro in relation to the values in control rats. The results of investigations of acid-base equilibrium parameters indicated that Ledacrine in toxic doses caused in rats metabolic acidosis associated with respiratory acidosis.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000138:Acidosis / Q000139:chemically induced; D000273:Adipose Tissue / Q000378:metabolism*; D000609:Aminoacridines / Q000008:administration & dosage*; D000818:Animals; D004822:Epididymis / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D005990:Glycerol / Q000008:administration & dosage*; D066298:In Vitro Techniques; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D009564:Nitracrine / Q000008:administration & dosage* / Q000633:toxicity; D051381:Rats; D013268:Stimulation, Chemical
D000609:Aminoacridines; D005230:Fatty Acids, Nonesterified; D009564:Nitracrine; D005990:Glycerol