title: Correlation of liver tumor morphology and weight to incidence of pulmonary metastases in the mouse.
abstract: Benzidine dihydrochloride administered in water at 0, 30, 60, 120, 200 or 400 ppm to 1664 mice induced a total of 368 hepatocellular carcinomas, of which 34 or 9.2% metastasized to the lungs. Liver tumors which were larger and heavier were more prone to metastasize and all that metastasized contained areas of prominent trabecular formation.
mesh_terms: D000818:Animals; D005260:Female; D008099:Liver / Q000033:anatomy & histology; D008113:Liver Neoplasms / Q000473:pathology*; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size