The carotid sinus-blood pressure reflex in conscious rabbits: the relative importance of changes in cardiac output and peripheral resistance.
This paper reports experiments to determine the relative roles of changes in cardiac output and systemic vascular resistance in determining the blood pressure response to intermittent step-changes and continuous sinusoidal changes in carotid sinus transmural pressure. Conscious rabbits with a variable-pressure capsule implanted around an innervated carotid sinus were used. After step-change in capsule pressure the approximate proportions of the changes in blood pressure attributable to changes in cardiac output were, during the pressor response, 7% after 2.5 s, 22% after 10 s and 27% at plateau, and during the depressor response 100%, 8% and 17%, respectively. During sinusoidal change in capsule pressure a mean 7% of the change in blood pressure over the full cycle was attributable to change in cardiac output.
D000818:Animals; D001794:Blood Pressure; D002302:Cardiac Output; D002346:Carotid Sinus / Q000502:physiology*; D006339:Heart Rate; D011311:Pressoreceptors / Q000502:physiology; D011817:Rabbits; D012018:Reflex / Q000502:physiology*; D014655:Vascular Resistance