Establishment of normal values in adults for zinc protoporphyrin (ZPP) using hematofluorometer: correlation with normal blood lead values.
Zinc protoporphyrin (ZPP) values were analyzed with a hematofluorometer on 395 non-occupationally lead exposed subjects. Blood lead (B-Pb) determinations were concurrently carried out with an extraction procedure using flameless atomic absorption method. Applying Hoffman's Statistical Analysis with a logarithmic transformation, a normal range for ZPP (a mean of 23 microgram/dL) was established with 40 microgram ZPP/dL on the upper limit of the 95% probability range. A value of 54 microgram ZPP/dL has been found to be a suitable cutoff value above which one generally finds B-Pb values greater than 40 microgram/dL. For B-Pb values (less than 40 microgram/dL) and ZPP values in our normal range, there was essentially no correlation. However, for elevated values of both, a correlation coefficient of 0.87 was found for log ZZP versus B-Pb. ZPP values for males appeared to increase with increasing age.
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007854:Lead / Q000097:blood*; D008297:Male; D008722:Methods; D008875:Middle Aged; D011166:Porphyrins / Q000097:blood*; D011524:Protoporphyrins / Q000097:blood*; D013054:Spectrophotometry, Atomic
D011166:Porphyrins; D011524:Protoporphyrins; C017803:zinc protoporphyrin; D007854:Lead