title: Formalin stress reaction of germfree and conventional mice treated with Bordetella pertussis vaccine.
abstract: Germfree and conventional mice responded similarly to pertussis vaccine treatment. In both groups, lymphocytosis and splenomegaly developed in a similar proportion. The formalin stress reaction of germfree and conventional mice with hypertrophic lymphoid organs induced by pertussis vaccine differed from that of untreated mice: the treated germfree and conventional mice showed a acute increase of lymphocytosis without an significant change in splenomegaly.
mesh_terms: D000818:Animals; D005260:Female; D005557:Formaldehyde / Q000009:adverse effects; D005790:General Adaptation Syndrome / Q000139:chemically induced / Q000503:physiopathology*; D005856:Germ-Free Life; D066298:In Vitro Techniques; D007958:Leukocyte Count; D008208:Lymphatic System / Q000187:drug effects*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D010567:Pertussis Vaccine / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects; D013312:Stress, Physiological / Q000503:physiopathology*
chemical_list: D010567:Pertussis Vaccine; D005557:Formaldehyde