title: Anti-Tm is anti-N polypeptide.
abstract: Anti-Tm defines an antigen in the MN blood group system, and 382 Tm + samples were found in tests on 900 random Caucasian, and 500 random Negro bloods. Of the 382 Tm + samples, 373 were also N +, but a further 625 N+ samples were nonreactive with anti-Tm. We have now shown that when the original anti-Tm serum is adsorbed free of anti-T, and is tested against neuraminidase-treated red blood cells, it has anti-N specificity. Further, while anti-Tm cannot be inhibited by sialoglycoprotein (SGP) preparations from untreated N+ red blood cells, it is inhibited by SGP fractions prepared from N+ red blood cells that have been pretreated with neuraminidase. It seems that anti-Tm is directed against a part of the polypeptide backbone of the N SGP.
mesh_terms: D000327:Adsorption; D000906:Antibodies; D001667:Binding, Competitive; D001789:Blood Group Antigens / Q000276:immunology*; D006801:Humans; D007048:I Blood-Group System / Q000276:immunology; D008951:MNSs Blood-Group System / Q000276:immunology*; D009439:Neuraminidase / Q000494:pharmacology; D010455:Peptides / Q000276:immunology*; D012794:Sialic Acids / Q000276:immunology; D012795:Sialoglycoproteins / Q000494:pharmacology
chemical_list: D000906:Antibodies; D001789:Blood Group Antigens; D007048:I Blood-Group System; D008951:MNSs Blood-Group System; D010455:Peptides; D012794:Sialic Acids; D012795:Sialoglycoproteins; D009439:Neuraminidase