[Tetracycline penetration into tissue by modified electro- and phonophoretic methods].
A total of 451 experiments (130 with the method of electrophoresis and 321 with the method of phonophoresis) were performed on healthy rabbits of the same species, age, weight and sex with the use of the galvanization apparatus "Potok-1" and ultrasound therapeutic apparatus "VTP-1". The penetration levels of tetracycline into the tissues after its administration with the modified methods of electro- and phonophoresis were determined. The dependence of the process on the current density, ultrasound intensity, time and antibiotic concentration was studied. The efficacy of the routine electro- and phonophoresis methods was compared with that of the modified ones. It was found that the tissue levels of tetracycline administered with the modified methods of electro- and phonophoresis increased with an increase in the current density or ultrasound intensity, the procedure time and antibiotic concentration. When tetracycline was administered with the modified method of electrophoresis its levels were highest in the skin, lower in the muscles and minimum in the bones. With the use of the modified method of phonophoresis the highest levels were in the skin, the lowest in the bones and the minimum in the muscles. The tissue levels of tetracycline administered with the modified methods of electro- and phonophoresis were higher than those obtained with the routine methods of electro- and phonophoresis.
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007478:Iontophoresis / Q000379:methods; D009132:Muscles / Q000187:drug effects; D011817:Rabbits; D012869:Skin Absorption / Q000187:drug effects; D013752:Tetracycline / Q000008:administration & dosage*; D013997:Time Factors; D014465:Ultrasonics
D013752:Tetracycline
Proniknovenie tetratsiklina v tkani modifitsirovannym sposobom élektro- i fonoforeza.