The pathogenesis of chronic haemophilic arthropathy.
Specimens of tissue from haemophilic synovium and articular cartilage were collected from 39 patients during reconstructive surgery. They were studied by histochemistry, electron microscopy and microprobe analysis. The detailed findings are presented and discussed. It is suggested that haemophilic arthropathy is the result of a number of mechanisms affecting the synovial lining which becomes progressively fibrotic and the hyaline cartilage which disintegrates and is eventually lost. Mechanical and chemical processes cause degeneration of cells but enzymatic processes appear to be primarily responsible for the degradation of the matrix of the articular cartilage.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002358:Cartilage, Articular / Q000032:analysis / Q000473:pathology*; D002648:Child; D006025:Glycosaminoglycans / Q000032:analysis; D006395:Hemarthrosis / Q000209:etiology* / Q000473:pathology; D006467:Hemophilia A / Q000150:complications*; D006485:Hemosiderin / Q000032:analysis; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D013583:Synovial Membrane / Q000032:analysis / Q000473:pathology*
D006025:Glycosaminoglycans; D006485:Hemosiderin