Effect of cyclophosphamide on serum ceruloplasmin oxidase activity in sarcoma bearing rats.
High levels of serum ceruloplasmin oxidase activity were detected in U strain isogenic male rats bearing a syngeneic sarcoma in all phases of tumoral evolution. Normal levels of ceruloplasmin were only observed after a single i.p. dose of cyclophosphamide (100 mg/kg). However subsequent weekly administration of the drug did not prevent the return of hyperceruloplasminemia in the tumor hosts. Normal rats treated similarly with cyclophosphamide presented a fall in the enzyme activity after the 1st dose.
D000818:Animals; D002570:Ceruloplasmin / Q000378:metabolism*; D003520:Cyclophosphamide / Q000494:pharmacology*; D004791:Enzyme Inhibitors; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000378:metabolism*
D004791:Enzyme Inhibitors; D003520:Cyclophosphamide; D002570:Ceruloplasmin