Phencyclidine (PCP)-structure versus reactivity.
Seventeen different compounds having structural similarities o PCP (phencyclidine) were analyzed by radioimmunoassay (RIA) using 125I-phencyclidine reagents (Roche). Affinities were compared with molecular structures and several observations were made. It was found that the three-ring structure (1-phenylcyclo-hexylpiperidine) is essential for reactivity. Changes in and to the cyclohexyl ring and/or the piperidine ring reduced reactivity, while changes in the phenyl ring increased reactivity.
D010622:Phencyclidine / Q000031:analogs & derivatives / Q000032:analysis*; D011863:Radioimmunoassay; D013329:Structure-Activity Relationship
D010622:Phencyclidine