Purification and characterization of amino-terminal pro-opiocortin peptides from human pituitary glands.
Two cystine-containing peptides isolated from human pituitaries were partially sequenced. The peptides are fragments derived from the amino-terminal of pro-opiocortin (NPOC) and have been chemically characterized as NPOC 1-28 (which lacks gamma-MSH) and NPOC 2-59. Their availability enables us to investigate new putative biological roles for the amino-terminal conserved sequence of pro-opiocortin.
D000595:Amino Acid Sequence; D002852:Chromatography, Ion Exchange; D006023:Glycoproteins / Q000302:isolation & purification; D006801:Humans; D010446:Peptide Fragments / Q000302:isolation & purification*; D010902:Pituitary Gland / Q000032:analysis*; D010907:Pituitary Hormones / Q000302:isolation & purification*; D010908:Pituitary Hormones, Anterior / Q000302:isolation & purification; D011333:Pro-Opiomelanocortin; D011498:Protein Precursors / Q000302:isolation & purification
D006023:Glycoproteins; D010446:Peptide Fragments; D010907:Pituitary Hormones; D010908:Pituitary Hormones, Anterior; D011498:Protein Precursors; C028182:proopiocortin fragments; D011333:Pro-Opiomelanocortin