Desensitization to the anticholinergic effects of atropine on isolated guinea pig ileum.
Guinea pig ileums in Tyrode solution develop a progressive desensitization to the effects of atropine (2-min exposure). This desensitization, followed carefully by a simplified method, is significant from the fourth hr. On the other hand, no desensitization develops to the effects of equilibrium exposure to atropine.
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D004361:Drug Tolerance; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects*; D013997:Time Factors
D001285:Atropine