Transport of radioactive oxygen, nitrogen and xenon into the rabbit thoracic aorta in situ.
An in situ preparation of the rabbit thoracic aorta has been used to study the transport of short-lived radioactive isotopes of oxygen (15O16O), nitrogen (13N14N) and an isotope of xenon (133Xe) from 0.9% NaCl into the artery wall. At a luminal hydrostatic pressure of 2 kPa the uptake of all three isotopes by the intima-media increased with time in experiments of up to 15 min duration. Uptake of labelled oxygen was an order of magnitude higher than that of xenon and almost two orders of magnitude higher than nitrogen uptake. Adventitial uptake was similar for all three species. For a perfusion time of 2 1/2 min, the intimal-medial uptake of all three gases increased by almost an order of magnitude as luminal pressure increased from 2 to 13 kPa. Adventitial uptake increased rapidly and at a similar rate for all three gases. The studies were limited in depth and accuracy by the small quantities of isotope available.
D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism*; D001692:Biological Transport; D006207:Half-Life; D006874:Hydrostatic Pressure; D008297:Male; D009584:Nitrogen / Q000378:metabolism*; D009590:Nitrogen Radioisotopes; D010101:Oxygen Consumption; D010104:Oxygen Radioisotopes; D011817:Rabbits; D014978:Xenon / Q000378:metabolism*; D014980:Xenon Radioisotopes
D009590:Nitrogen Radioisotopes; D010104:Oxygen Radioisotopes; D014980:Xenon Radioisotopes; D014978:Xenon; D009584:Nitrogen