title: Choline chloride fails to improve cognition of Alzheimer's disease.
abstract: Seven mildly to moderately demented patients with Alzheimer's disease were treated with either placebo or choline chloride (50, 100 and 200 mg/kg/24 hrs) in a double blind, crossover study. Detailed psychometric analysis was carried out at the end of each two-week period of drug or placebo administration. No subjects showed significant overall improvement at any dose level despite more than a doubling of the baseline plasma choline level.
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D002794:Choline / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D003071:Cognition / Q000187:drug effects*; D003704:Dementia / Q000188:drug therapy*; D003967:Diarrhea / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D008875:Middle Aged
chemical_list: D002794:Choline