title: Peripheral and central vascular compliances in conscious normotensive and spontaneously hypertensive rats.
abstract: Changes of left atrial (LAP) and right atrial pressure (RAP) upon 10% and 20% blood volume expansion were studied in conscious spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKR) with intact nervous cardiovascular control. In a separate series the changes of central (CBV) and peripheral (PBV) blood volumes upon similar increases of total blood volume (TBV) were measured as well, throughout using male, adult SHR and WKR in both series. During volume expansion both LAP and RAP increased significantly more in SHR than in WKR, as did CBV, while PBV increased significantly less in SHR than in WKR. Total "effective' vascular compliance, defined as delta TBV/delta RAP, was significantly lower in SHR. From the two series of measurements central (CBV/LAP) and peripheral (PBV/RAP) vascular compliances could be separately deduced. Central vascular compliance was nearly 50% lower in SHR than in WKR. However, "unstressed' volume of the peripheral compartment appeared to be rather normal in SHR compared to WKR. It is therefore suggested that the decreased total vascular compliance seen in essential hypertension and in SHR is mainly due to a decreased distensibility of the systemic capacitance vessels.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001808:Blood Vessels / Q000502:physiology* / Q000503:physiopathology; D001810:Blood Volume; D003187:Compliance; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains