[Species differences in pharmaco-kinetics of chemicals. Correlations with toxicity (author's transl)].
The species differences in kinetics of drugs or toxics were studied in laboratory and domestic animals at various stages of the fate in the body: - absorption, - distribution, blood transport, binding on plasmatic proteins, tissues; placenta passage, - elimination via the kidney, bile, and diverses secretions. Since they are very important in species differences bio-transformations of chemical substances were studied separately. The toxicological or pharmacological implications of these differences were shown from a theoretical point of view (phenomena of passage through the membranes), an experimental point of view (choice of species, extrapolation from animal to man) and from the veterinary point of view.
D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D001798:Blood Proteins / Q000378:metabolism; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics; D008431:Maternal-Fetal Exchange; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011247:Pregnancy; D011485:Protein Binding; D013045:Species Specificity; D014018:Tissue Distribution
D001798:Blood Proteins; D004364:Pharmaceutical Preparations
Variations inter-spécifiques du métabolisme des substances chimiques. Relations avec la toxicité.