Epididymal aldehyde dehydrogenase: a pharmacologic profile.
The in vivo effect of various agents, with different pharmacologic properties, on cytosolic EP-ALDH was studied in the rat. Injection of a large dose of PYZ inhibited EP-ALDH 16 h after the injection. Short-term administration of a moderate daily dosage of PYZ also inhibited endogenous EP-ALDH from saline controls. Semichronic administration of a small daily dosage of DIS resulted in inhibition of EP-ALDH. Short-term administration of drugs with various pharmacologic profile produced little change in the specific activity of EP-ALDH. This is compared with an induction and an inhibition of T-ALDH as a function of treatment with an antiandrogen and an estrogenic drug, respectively. The results show lack of response of EP-ALDH towards pharmacologic intervention which may imply certain specificity for EP-ALDH.
D000284:Administration, Oral; D000444:Aldehyde Dehydrogenase; D000445:Aldehyde Oxidoreductases / Q000378:metabolism*; D000726:Androgen Antagonists / Q000494:pharmacology; D000818:Animals; D004221:Disulfiram / Q000008:administration & dosage / Q000494:pharmacology; D004822:Epididymis / Q000201:enzymology*; D004967:Estrogens / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D011720:Pyrazoles / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000201:enzymology
D000726:Androgen Antagonists; D004967:Estrogens; D011720:Pyrazoles; D000445:Aldehyde Oxidoreductases; D000444:Aldehyde Dehydrogenase; D004221:Disulfiram