Photorepair of pyrimidine dimers in human skin in vivo.
The exposure of human skin in vivo to UV radiation emitted from a sunlamp induces the formation of pyrimidine dimers. The number of dimers, as detected by UV-endonuclease, decreases following exposure of the UV-irradiated skin to visible wavelengths of light. These results suggest that humans possess a mechanism by which pyrimidine dimers are photorepaired upon illumination of human skin in vivo with visible light.
D000328:Adult; D004260:DNA Repair / Q000528:radiation effects*; D004255:Deoxyribodipyrimidine Photo-Lyase / Q000378:metabolism; D006801:Humans; D008027:Light; D008297:Male; D011740:Pyrimidine Dimers / Q000378:metabolism / Q000528:radiation effects*; D012867:Skin / Q000378:metabolism / Q000528:radiation effects*; D014466:Ultraviolet Rays / Q000009:adverse effects
D011740:Pyrimidine Dimers; D004255:Deoxyribodipyrimidine Photo-Lyase