Effects of alterations in drug metabolism on chloroform-induced cardiac arrhythmias in rabbits.
Control rabbits or those treated with phenobarbital to induce drug metabolism or SKF 525A or Lilly 18947 to inhibit were exposed by inhalation to 10,500 ppm chloroform for one hour. Phenobarbital treatment decreased blood levels only prior to reaching equilibrium and did not alter the response to epinephrine-induced cardiac arrhythmias. The inhibitors, despite causing higher blood levels of chloroform, did not alter its cardiotoxicity.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D001713:Biphenyl Compounds / Q000494:pharmacology; D002725:Chloroform / Q000378:metabolism / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System; D004048:Diethylamines / Q000494:pharmacology; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology; D011817:Rabbits
D001713:Biphenyl Compounds; D004048:Diethylamines; C002109:Lilly 18947; D002725:Chloroform; D003577:Cytochrome P-450 Enzyme System; D011335:Proadifen; D004837:Epinephrine; D010634:Phenobarbital