title: [Epidemiology and genetics of hemophilia].
abstract: From own examinations a survey of data concerning morbidity and genealogy of haemophilia is presented. Their comparison with data from literature shows that the total number of haemophiliacs referred to the population (1 : 11,000 males) and the relation of haemophilia A : B (4.5 : 1) vastly corresponds in the middle and north European area. The total number of haemophiliacs which is to be expected for a larger space can approximately be estimated, e. g. for the GDR the number amounts to about 1,200 to 1,300 haemophiliacs. Till now this number has not yet been obtained. At a high percentage the manifestation of the disease takes place in the first two years of life. The greatest number of the haemophiliacs is at present 25 to 40 years old. The fertility rate is clearly different between haemophilia A (0.33) and B (0.84). The number of the female conductors of all variants is certainly double the number as that of the haemophiliacs.
mesh_terms: D006580:Genetic Carrier Screening; D005859:Germany, East; D006467:Hemophilia A / Q000453:epidemiology / Q000235:genetics*; D002836:Hemophilia B / Q000453:epidemiology; D006801:Humans; D008297:Male
vernacular_title: Zur Epidemiologie und Genetik der Hämophilie.