[Systematic detection of elevated low density lipoproteins (LDL and VLDL) in a population of 2656 blood donors].
The atherogenic low density lipoproteins were evaluated using two turbidimetric methods: one based on the precipitation of LDL and VLDL by heparin-CaCl2 and the other on the precipitation of the VLDL by sodium dodecyl sulfate. In search of hyperlipoproteinemia, both tests were applied to a population of blood donors aged from 18 to 60 years. when both tests were negative, hyperlipoproteinemia can be excluded without quantitative evaluation of cholesterol and triglycerides levels. If the heparin-CaCl2 test is high and the SDS normal it can be concluded that it is a case of type IIa hyperlipidemia. When both test are high, further investigations are required. In the present study, corresponding to the screening of the sera from 2656 blood donors (including 1280 males and 1376 females), the high level of atherogenic lipoproteins is most frequently observed in the males (10 per cent for men and 2,5 per cent for women). This frequency increases with age.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001782:Blood Donors; D002122:Calcium Chloride; D011232:Chemical Precipitation; D005260:Female; D006493:Heparin; D006801:Humans; D006949:Hyperlipidemias / Q000175:diagnosis*; D008077:Lipoproteins, LDL / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009391:Nephelometry and Turbidimetry; D012737:Sex Factors; D012967:Sodium Dodecyl Sulfate
D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D012967:Sodium Dodecyl Sulfate; D006493:Heparin; D002122:Calcium Chloride
Dépistage systématique des élévations des lipoprotéines de faible densité (LDL et VLDL) dans une population de 2656 donneurs de sang.