[Significance of aromatic amino acid residues for certain functions of immunoglobulins].
The photooxidation of rabbit and human IgG in the presence of methylene blue leads to loss of antibody and complement fixation activity. Under these conditions 46% of tryptophan, 30% of tyrosine and 42% of phenylalanine are destroyed. The IgG incubation with methylene blue in darkness causes no changes in the content of aromatic amino acid residues or in the antibody activity, but leads to deterioration in their complement fixation properties.
D000818:Animals; D000936:Antigen-Antibody Complex; D003168:Complement Fixation Tests; D006801:Humans; D007074:Immunoglobulin G; D007700:Kinetics; D008751:Methylene Blue; D010649:Phenylalanine; D010782:Photolysis; D011817:Rabbits; D014364:Tryptophan; D014443:Tyrosine
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D014443:Tyrosine; D010649:Phenylalanine; D014364:Tryptophan; D008751:Methylene Blue
Znachenie aromaticheskikh aminokislotnykh ostatkov dlia nekotorykh funktsiĭ immunoglobilinov.