[Effect of splenin and its fractions on the functional state of the adrenal cortex].
Effect of splenin (1 ml) and its fractions (0.5 ml) on adrenocortical function was studied after a single intramuscular injection of the preparations into rats. Splenin and its fractions containing water-soluble substances reduced the content of ascorbic acid in the rat adrenals thereby indicating the increased synthesis of adrenocortical hormones. Adenosine-5-monophosphate is one of the basic biological substances contained by splenin and its water-soluble fractions. It produces a stimulant effect on the synthesis of adrenocortical hormones.
D000249:Adenosine Monophosphate / Q000032:analysis; D000302:Adrenal Cortex / Q000032:analysis*; D000818:Animals; D001205:Ascorbic Acid / Q000032:analysis*; D008297:Male; D051381:Rats; D013946:Thymopoietins / Q000032:analysis / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*
D013946:Thymopoietins; D013951:Thymus Hormones; D000249:Adenosine Monophosphate; C032841:thymopoietin III; D001205:Ascorbic Acid
Vliianie splenina i ego fraktsiĭ na funktsional'noe sostoianie kory nadpochechnikov.