title: Muscle metabolism during exercise in men operated upon for coarctation of the aorta in childhood.
abstract: Muscle biopsies were taken from the quadriceps muscle during rest and exercise in 16 young men (ages 16-28 years) operated upon for coarctation of the aorta during childhood and 10 healthy men (ages 19-25 years). Resting values and depletion after exercise for ATP, CP and glycogen were similar in the two groups. Muscle-lactate concentrations were higher at all levels of exercise in the operated group, while blood-lactate concentrations did not differ. It is concluded that the operated patients have a disturbed blood-flow regulation and a somewhat impaired blood-flow to the working leg muscles.
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D001017:Aortic Coarctation / Q000503:physiopathology / Q000601:surgery*; D006003:Glycogen / Q000378:metabolism; D006439:Hemodynamics; D006801:Humans; D007773:Lactates / Q000097:blood / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism*; D010101:Oxygen Consumption; D010725:Phosphocreatine / Q000378:metabolism; D005082:Physical Exertion; D012119:Respiration
chemical_list: D007773:Lactates; D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D006003:Glycogen