The effect of 15(R)-15-methyl prostaglandin E2 on basal and meal stimulated serum gastrin in duodenal ulcer patients.
Basal and meal-stimulated serum gastrin with or without prior intake of 100 mcg 15(R)-15-methyl prostaglandin E2 (PG) in encapsulated form were measured in 40 patients with active duodenal ulcer disease at the start and at the end of a 4 week treatment period with 100 mcg PG q i d or placebo (Pl). Basal serum gastrin levels did not change throughout the study. Neither was there a blunting of the meal-stimulated serum gastrin release by PG as has been previously observed. The enhanced healing rate (68.4% during PG compared to 33.3% during Pl) can therefore not be explained by changes in basal or meal-stimulated serum gastrin.
D000328:Adult; D001101:Arbaprostil; D004381:Duodenal Ulcer / Q000097:blood*; D004435:Eating; D005260:Female; D005755:Gastrins / Q000097:blood*; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011459:Prostaglandins E, Synthetic
D005755:Gastrins; D010919:Placebos; D011459:Prostaglandins E, Synthetic; D001101:Arbaprostil