title: Tolerance to corticoids? Guinea pig epithelium as an experimental system.
abstract: The antiacanthogenic effect of topical applied steroids is well known and maybe exactly assessed and quantified by means of the test procedure described. A 0.1% clobetasol-17-propionate solution induces an antiacanthogenic effect of 27.5% after a 28-day treatment period. After 84 days, the skin further treated with the corticosteroid shows an antiacanthogenic effect of 23.7% and after 118 days of 39%. A steroid tolerance of epithelial layer on guinea pig skin cannot be derived from our results.
mesh_terms: D000818:Animals; D001623:Betamethasone / Q000031:analogs & derivatives*; D002990:Clobetasol / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D004848:Epithelium / Q000187:drug effects; D006168:Guinea Pigs; D012867:Skin / Q000187:drug effects*; D012880:Skin Pigmentation / Q000187:drug effects
chemical_list: D001623:Betamethasone; D002990:Clobetasol