Prognostic factors in multiple myeloma: parametric analysis in each abnormal protein type.
The prognostic significance of age, hemoglobin level, leukocyte and platelet counts, total protein and serum M-component concentrations, total protein other than M-component (TP-MC) concentration, serum uric acid level (all at the time of diagnosis), and interval from onset to diagnosis was studied retrospectively in 118 patients who died of multiple myeloma. Before analysis, the patients were separated into 7 subgroups, i.e., IgG IgA, Bence-Jones type, IgG.k, IgG.lambda, IgG with Bence-Jones proteinuria (IgG (+)), and IgG without Bence-Jones proteinuria (IgG (-)). Correlation analysis revealed that younger patients in the IgG.lambda and IgG(-) groups survived longer, that total protein positively correlated to survival in the IgG and IgG.lambda groups, that higher TP-MC concentration correlated to longer survival in the IgG, IgG.k, IgG(+), and IgG(-) groups and that higher uric acid levels adversely affected survival in the IgG.k group. All other factors were insignificant in all the subgroups. To assess the interrelationships among predictor variables, and to estimate their contribution to survival, a multiple regression analysis was performed. The resulting R2 values ranged from 0.28 (IgG) to 0.46 (IgG.lambda).
D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000401:mortality; D009194:Myeloma Proteins / Q000032:analysis*; D011379:Prognosis; D012044:Regression Analysis
D006454:Hemoglobins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D009194:Myeloma Proteins