[Serotonin distribution between plasma and platelets in clinically healthy children].
Serotonin distribution between plasma and platelets was examined in 34 clinically healthy children. We measured 5-HT with spectrofluorometric method. We obtained no correlation between plasma and platelets 5-HT. Serotonin is more concentrated in platelets than in plasma. In fact, platelets uptake 5-HT even at low plasma concentration, by an active transport mechanism and store it in granular substructures. 5-HT uptake occurs in similar way both in platelets and in 5-HT neurons. MOreover, the 5-HT receptors react to 5-HT agonist or antagonist drugs as the receptors of some SNC areas (not those with dense 5-HT innervation). Therefore, platelets might be used as indication for 5-HT neurons activity in those SNC regions whose receptors react to drugs as platelets receptors.
D001792:Blood Platelets / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D009474:Neurons / Q000378:metabolism; D012016:Reference Values; D012701:Serotonin / Q000097:blood*; D013050:Spectrometry, Fluorescence; D014018:Tissue Distribution
D012701:Serotonin
Distribuzione della serotonina nel plasma e nelle piastrine di soggetti in età pediatrica clinicamente sani.