title: Tranylcypromine isomers in the treatment of Parkinson's disease. Biochemical effects.
abstract: Isomers of the monoamine oxidase inhibitor tranylcypromine were administered separately to 15 hospitalized parkinsonian patients. The activity of the platelet enzyme, the plasma and urinary tranylcypromine, were measured. While the (+)isomer inhibited monoamine oxidase to a greater extent, both isomers increased plasma phenylethylamine. Differences between the pharmacokinetics of the two isomers were substantial, (-)tranylcypromine being excreted much faster.
mesh_terms: D001792:Blood Platelets / Q000201:enzymology; D006801:Humans; D007700:Kinetics; D008995:Monoamine Oxidase / Q000378:metabolism; D010300:Parkinson Disease / Q000188:drug therapy* / Q000378:metabolism; D010627:Phenethylamines / Q000378:metabolism; D013237:Stereoisomerism; D014191:Tranylcypromine / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D010627:Phenethylamines; D014191:Tranylcypromine; D008995:Monoamine Oxidase