Decreased bile acid pool neonates of guinea pigs fed cholesterol during pregnancy.
Feeding 0.25% cholesterol-containing chow to guinea pigs during pregnancy resulted in a) significantly higher plasma cholesterol in the neonates, b) a striking decrease in the total bile acid pool of the neonates, with a significant reduction in the pool of chenodeoxycholic acid, and c) and increase in the proportion of bile acids associated with the neonatal liver. These results suggest that feeding cholesterol to guinea pigs during pregnancy has undesirable effects in the neonate in terms of the development of cholesterol degradation mechanisms.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism*; D002635:Chenodeoxycholic Acid / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D004064:Digestive System / Q000378:metabolism; D005260:Female; D006168:Guinea Pigs; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
D001647:Bile Acids and Salts; D002791:Cholesterol, Dietary; D002635:Chenodeoxycholic Acid; D002784:Cholesterol