Central hypotensive effect of diprenorphine in normotensive rat and SHR.
Opioid compounds injected intracisternally in rats induce a centrally-mediated increase in blood pressure. In the present study, the intracisternal injection of an antagonist of opioid compounds, diprenorphine was examined. Diprenorphine caused a similar blood pressure decrease in spontaneously hypertensive rats and normotensive control Wistar Kyoto rats both in young and adult animals. This represents an important argument concerning a role of endogenous opioids in blood pressure control in anaesthetized rats but suggests that brain stem endogenous opioids may not be involved in the mechanism of hypertension.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002490:Central Nervous System / Q000187:drug effects; D002946:Cisterna Magna; D004174:Diprenorphine / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology*; D007267:Injections; D007275:Injections, Intravenous; D009019:Morphinans / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009019:Morphinans; D004174:Diprenorphine