title: Sodium deprivation during thiamin deficiency in rats: hormonal, histological, and behavioral responses.
abstract: Adrenal function, determined by adrenocortical hormone measurement and histological studies, was examined in adult rats fed on of the following four diets for four weeks: thiamin-sufficient, sodium-adequate (+B/+Na) or inadequate (+B/-Na); and thiamin-deficient, sodium-adequate (-B/+NA) or inadequate (-B/-Na). Thiamin-deficiency significantly depressed plasma and urinary aldosterone responses to sodium deprivation; on the other hand, thiamin status had no consistent significant effect on aldosterone levels in sodium-adequate rats. Plasma corticosterone levels were significantly elevated by thiamin deficiency and yet unaffected by sodium deprivation. Histological examination of the adrenal glands in thiamin-deficient rats revealed a suboptimal zona glomerulosa response to sodium deprivation. Juxtaglomerular granulation in the kidneys indicated that renin secretion was adequate in thiamin-deficient rats. In another experiment, salt (NaCl) appetite development was confirmed in adult rats fed the -B/+Na diet. A direct role of aldosterone in producing salt appetite in thiamin-deficient rats seems unlikely since aldosterone levels were essentially unchanged in rats fed the -B/+Na diet. Instead, the elevated corticosterone levels in thiamin-deficient rats suggest a general stress mechanism for salt appetite development of which the reduced aldosterone response to sodium deprivation is a symptom.
mesh_terms: D000311:Adrenal Glands / Q000473:pathology; D000450:Aldosterone / Q000097:blood / Q000652:urine; D000818:Animals; D001066:Appetite / Q000502:physiology*; D003345:Corticosterone / Q000097:blood; D007668:Kidney / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000172:deficiency*; D012965:Sodium Chloride; D013832:Thiamine Deficiency / Q000473:pathology / Q000503:physiopathology*
chemical_list: D012965:Sodium Chloride; D000450:Aldosterone; D012964:Sodium; D003345:Corticosterone