The effect of intravenous fluid administration on the cardiopulmonary sequelae of burn wound sepsis.
Burned sheep, which were infected with Pseudomonas aeruginosa and received intravenous fluid administration, were compared to similarly infected animals allowed free access to oral fluid. In both instances cardiopulmonary variables were measured for three days following inoculation. Both groups demonstrated an elevation in heart rate and hematocrit and a fall in PaO2 and leukocyte count. The animals that received fluid resuscitation demonstrated basically the same cardiovascular response to sepsis as animals that resuscitated themselves. We conclude that the hypodynamic response to sepsis is not secondary to an inadequate fluid intake.
D000818:Animals; D002056:Burns / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D005440:Fluid Therapy; D006400:Hematocrit; D006439:Hemodynamics; D007958:Leukocyte Count; D010100:Oxygen / Q000097:blood; D012756:Sheep; D014946:Wound Infection / Q000097:blood / Q000503:physiopathology / Q000628:therapy*
D010100:Oxygen