Induction of sister chromatid exchanges and chromosome aberrations in cultured mammalian cells by N-nitrosocimetidine.
N-Nitrosocimetidine (NC) induces significant numbers of sister chromatid exchanges (SCE) and chromosome aberrations in cultured Chinese hamster ovary (CHO) cells even at a concentration of 1.2 x 10(-7) M. Its effectiveness in SCE induction is about two thirds that of the gastric carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). These results constitute further evidence that NC possesses carcinogenic activity.
D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations; D002927:Cimetidine / Q000031:analogs & derivatives / Q000494:pharmacology*; D006224:Cricetinae; D003412:Cricetulus; D003434:Crossing Over, Genetic / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006146:Guanidines / Q000494:pharmacology*; D009603:Nitroso Compounds / Q000494:pharmacology; D010053:Ovary; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D006146:Guanidines; D009603:Nitroso Compounds; C019503:nitrosocimetidine; D002927:Cimetidine