Synthesis and biological activity of the peroxy-ATP analogue, adenylyl 5'-peroxydiphosphate.
An analogue of adenosine 5'-triphosphate, adenylyl 5'-peroxydiphosphate (beta, gamma-peroxy-ATP), in which a peroxide linkage replaces the terminal bridge oxygen of the triphosphate chain, has been synthesized. The chemical and biological properties of beta, gamma-peroxy-ATP in representative enzyme systems demonstrate its potential usefulness as a probe of enzymatic mechanism and structure.
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D007202:Indicators and Reagents
D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; C032451:adenylyl 5'-peroxydiphosphate; D000255:Adenosine Triphosphate