[Seizures due to lithium intoxication (author's transl)].
Lithium intoxication may present as seizures, which have been observed when plasma lithium concentrations were decreasing. The neurotoxic effect of lithium could be due to a rise in intra-/extra-cellular lithium ratio. Intracellular retention of lithium reflected in rapid fall of plasma concentrations during treatment would modify cell membrane properties and increase neuronal excitability. Such a mechanism would explain the occurrence of seizures despite therapeutic plasma lithium concentrations.
D000328:Adult; D004912:Erythrocytes / Q000032:analysis; D006801:Humans; D008094:Lithium / Q000097:blood / Q000506:poisoning*; D008297:Male; D009046:Motor Neurons / Q000187:drug effects; D012640:Seizures / Q000097:blood / Q000139:chemically induced*
D008094:Lithium
Convulsions par intoxication au lithium.