High dose buprenorphine for postoperative analgesia.
Buprenorphine was given intravenously to produce analgesia in the immediate postoperative period, the dose being titrated against the response of each patient in order to obtain complete freedom from pain. In 50 patients following lower segment Caesarean section under general anaesthesia, buprenorphine in the dose range 0.4-7.0 mg was found to be a potent, long lasting and safe analgesic. Serial blood gas estimations performed on ten of the patients confirmed the clinically observed lack of respiratory depression.
D000328:Adult; D002047:Buprenorphine / Q000009:adverse effects / Q000627:therapeutic use*; D002585:Cesarean Section; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D009019:Morphinans / Q000627:therapeutic use*; D010149:Postoperative Pain / Q000517:prevention & control*; D011247:Pregnancy; D012131:Respiratory Insufficiency / Q000139:chemically induced; D013997:Time Factors
D009019:Morphinans; D002047:Buprenorphine