Glomerular permeability for proteins of high molecular weight entrapped in liposomes.
The glomerular filtration barrier is known to be negatively charged. Previous experiments have shown the importance of the electrical charge for permeability. We looked for permeability characteristics of proteins entrapped in liposomes with negative and positive charge detecting that the positive charge enables the protein to pass the glomerular filtration barrier.
D000818:Animals; D002199:Capillary Permeability; D002463:Cell Membrane Permeability; D005260:Female; D006651:Histocytochemistry; D007678:Kidney Glomerulus / Q000098:blood supply / Q000378:metabolism* / Q000648:ultrastructure; D008081:Liposomes / Q000378:metabolism* / Q000652:urine; D046911:Macromolecular Substances; D008297:Male; D008854:Microscopy, Electron; D008871:Microvilli / Q000648:ultrastructure; D008970:Molecular Weight; D011506:Proteins / Q000378:metabolism*; D011507:Proteinuria; D051381:Rats; D011919:Rats, Inbred Strains
D008081:Liposomes; D046911:Macromolecular Substances; D011506:Proteins