Concentration of perfluorohexyl bromide in dog plasma and selected tissues.
Beagle dogs received single perfluorohexyl bromide doses, either 30.2 g/kg po or 3.8 g/kg intratracheally. The apparent first-order plasma half-life during the terminal elimination phase was approximately 8 hr after oral treatment and greater than 8 hr after intratracheal administration. Tissue analysis showed the highest mean concentration of the compound in abdominal fat 1 week after intratracheal administration. One dog had detectable levels in abdominal fat 4 weeks after treatment by either administration route.
D000284:Administration, Oral; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000378:metabolism*; D004285:Dogs; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage / Q000378:metabolism*; D007442:Intubation, Intratracheal; D008297:Male; D014018:Tissue Distribution; D006842:Hydrocarbons, Brominated
D003287:Contrast Media; D005466:Fluorocarbons; C003071:perfluorohexylbromide; D006842:Hydrocarbons, Brominated