Studies on the mechanism of action of a novel anorectic agent, (--)-threo-chlorocitric acid.
(--)-threo-Chlorocitric acid, a novel and potent anorectic agent in rats and dogs, decreased food intake to a comparable extent in rats fed chow, low fat, or high fat diets. This inhibition of food intake was not the result of conditioned aversion. Unlike (--)-threo-hydroxycitric acid, a structurally related compound which inhibits fatty acid synthesis, (--)-threo-chlorocitric acid did not suppress fatty acid synthesis in an isolated hepatocyte system or in vivo. (--)-threo-Chlorocitric acid significantly delayed the rate of gastric emptying. Of the four stereoisomers of chlorocitric acid, (--)-threo-chlorocitric acid was the most active both in delaying gastric emptying and producing anorexia in rats. It is suggested that the mechanism by which (--)-threo-chlorocitric acid may suppress food intake is through a reduction of gastric emptying.
D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects; D002951:Citrates / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001067:Appetite Depressants; D002951:Citrates; C032936:chlorocitric acid