A method for achieving rapidly steady-state blood concentrations of I.V. drugs.
The theoretical basis of a pharmacokinetic method to obtain rapidly and maintain a steady plasma concentration of an i. v. drug is described. Computer simulations of morphine disposition in man, using pharmacokinetic constants obtained from the literature, are provided as examples of steady-state dose regimens. The usefulness and potential limitations of the method are discussed.
D003201:Computers; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007700:Kinetics; D008722:Methods; D008954:Models, Biological; D009020:Morphine / Q000008:administration & dosage / Q000097:blood*
D009020:Morphine