title: Choline stimulates nicotinic receptors on adrenal medullary chromaffin cells to induce catecholamine secretion.
abstract: Choline stimulated secretion of catecholamines from primary dissociated cultures of bovine adrenal medullary chromaffin cells by interacting with nicotinic receptors. Secretion was readily detected at a choline concentration of 1 millimole per liter and was maximal at 3 to 10 millimoles per liter; it was completely calcium-dependent. Further analysis suggested that choline acts as a partial nicotinic agonist.
mesh_terms: D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000313:Adrenal Medulla / Q000502:physiology*; D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D002417:Cattle; D002478:Cells, Cultured; D002794:Choline / Q000494:pharmacology*; D002838:Chromaffin System / Q000502:physiology*; D005089:Exocytosis / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011978:Receptors, Nicotinic / Q000187:drug effects*
chemical_list: D002395:Catecholamines; D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic; D002794:Choline; D000109:Acetylcholine