Effect of three bile acid binding polymers on the biosynthesis of 14C-cholesterol from 14C-sodium acetate in the rat.
The relative activity of three bile acid binding polymers in increasing cholesterol biosynthesis in the rat from 14C-acetate was determined by measuring blood levels of 14C-cholesterol after intraperitoneally administered 14C-acetate. CAT-FLOC and 3,3-ionene were 4-5 times more active than cholestyramine in this study which correlated well with the results of hypocholesteremic testing in dogs.
D000085:Acetates / Q000378:metabolism*; D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D002784:Cholesterol / Q000096:biosynthesis*; D002792:Cholestyramine Resin / Q000494:pharmacology; D011095:Polyethylenes; D011108:Polymers / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D051381:Rats
D000085:Acetates; D001647:Bile Acids and Salts; D011095:Polyethylenes; D011108:Polymers; D000644:Quaternary Ammonium Compounds; D002792:Cholestyramine Resin; C041004:poly-N,N-dimethyl-N,N-diallylammonium chloride; C028023:3,3-ionene; D002784:Cholesterol