title: [Hydrophobic parameters in homologous series of psychopharmaceuticals].
abstract: The 1-octanol/water partition coefficients of sets of 1,4-benzodiazepine and phenothiazine derivatives are determined. The values of the hydrophobic parameters obtained by shake-flask procedure are correlated to the corresponding HPLC retention times. The existence of linear correlations between the two experimentally determined parameters clearly show that chromatographic indices model excellently the shake-flask parameters.
mesh_terms: D001569:Benzodiazepines; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D010640:Phenothiazines
chemical_list: D010640:Phenothiazines; D001569:Benzodiazepines
vernacular_title: Parametri idrofobici in serie omologhe di psicofarmaci.