title: [Multiphasic neuromuscular blockade during and following regional application of succinylcholine in man (author's transl)].
abstract: The influence of the isolated arm technique on the development of the neuromuscular block induced by succinylcholine (suxamethonium) was investigated in 11 anesthetized patients using the adductor pollicis twitch method. A multiphasic course was shown: phase A (=occlusionphase) during ischemia; phases B1 and B2 (=post occlusion phases) after restoring circulation. The mean maximal depression of control twitch height increased from 60.4% in phase A to 75.2% in phase B1 and on up to 96.4% in phase B2. The mean onset time from releasing the tourniquet to first depression of twitch height amounted to 4.9 s in phase B1 and 27.8 s in phase B2. The multiphasic course is interpretated as the consequence of a temporary disequilibrium of muscle perfusion with the regional method. A neuromuscular effect after opening the tourniquet was evident in 3 out of 8 simultaneous studies on the control arm. An abnormal myotonic reaction was observed repeatedly in 1 patient.U
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009466:Neuromuscular Blocking Agents; D012039:Regional Blood Flow / Q000187:drug effects; D013390:Succinylcholine / Q000494:pharmacology*
chemical_list: D009466:Neuromuscular Blocking Agents; D013390:Succinylcholine
vernacular_title: Mehrphasige neuromuskuläre Blockade während und nach regionaler Anwendung von Succinylcholin beim Menschen.