[Lipid peroxidation and damage to the mixed function oxidase system in membranes of the endoplasmic reticulum in the presence of liver ischemia].
The content of endogenous lipid peroxidation products and variations in mixed function oxygenases were examined in liver microsomes of rats exposed to thermal ischemia of varying duration (15, 30, 60 and 120 min). The development of ischemic injury was accompanied by the accumulation of lipid hydroperoxides and Schiff's base, by the lowering of the content of cytochrome P-450 and diminution of the activity of NADPH-cytochrome P-450 reductase. The maximum changes were demonstrated 2 hours after ischemia. The presence of a reverse correlation between the content of lipid peroxidation products and the content of cytochrome P-450 was recorded.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D004721:Endoplasmic Reticulum / Q000201:enzymology; D007511:Ischemia / Q000378:metabolism*; D008054:Lipid Peroxides / Q000032:analysis*; D008099:Liver / Q000098:blood supply*; D008297:Male; D008862:Microsomes, Liver / Q000032:analysis / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009245:NADH Dehydrogenase / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D008054:Lipid Peroxides; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D009245:NADH Dehydrogenase
Perekisnoe okislenie lipidov i povrezhdenie sistemy oksigenaz so smeshannoĭ funktsieĭ v membranakh éndoplazmaticheskogo retikuluma pri ishemii pecheni.