Endocrine effects of domperidone: a peripheral dopamine blocking agent.
In the present study, effects of domperidone, a peripheral dopamine blocking agent, on prolactin and growth hormone were examined to determine whether dopamine regulation of these hormones involved structures external to the blood-brain barrier. A clearcut elevation in prolactin was produced by domperidone. GH response to apomorphine was partially blocked by domperidone.
D000328:Adult; D001058:Apomorphine / Q000494:pharmacology; D004294:Domperidone / Q000031:analogs & derivatives / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects
D004294:Domperidone; C017357:halopemide; D011388:Prolactin; D013006:Growth Hormone; D001058:Apomorphine