Cerebrovascular response to hypoxia in baroreceptor- and chemoreceptor-denervated dogs.
Cerebral hemodynamic responses to arterial hypoxemia were studied in anesthetized paralyzed dogs that were or that had undergone carotid baroreceptor denervation, carotid chemoreceptor denervation, vagotomy, or both vagotomy and carotid sinus nerve section. Arterial O2 content was lowered from control (19.0 vol%) to 9.6 vol% by either decreasing arterial O2 tension [hypoxic hypoxemia (HH)] or increasing carboxyhemoglobin saturation[carbon-monoxide hypoxemia (COH)] at normal O2 tension. In intact animals (composite control values from all groups) HH and COH resulted in similar increases in cerebral blood flow (to 205 and 197% of control, respectively). Cerebral vascular resistance decreased more with COH than with HH (to 42 vs. 60% of control). The response from carotid baroreceptor-denervated animals and from vagotomized animals did not differ from that of the intact animals. After carotid chemoreceptor denervation and combined carotid sinus nerve section and vagotomy, both HH and COH increased cerebral blood flow to 194% of control (same increase as in intact animals, carotid baroreceptor-denervated animals, and vagotomized animals) and produced equal reductions in cerebral vascular resistance (to 34% of control). These data show that the carotid and aortic chemoreceptors are not necessary for the increase in cerebral blood flow provoked by hypoxemia and that this response is not modified by the carotid and aortic baroreceptors.
D000818:Animals; D001794:Blood Pressure; D001921:Brain / Q000378:metabolism; D002319:Cardiovascular System / Q000503:physiopathology*; D002339:Carotid Arteries / Q000502:physiology; D002346:Carotid Sinus / Q000294:innervation; D002628:Chemoreceptor Cells / Q000503:physiopathology*; D003714:Denervation; D004285:Dogs; D005260:Female; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000503:physiopathology*; D007700:Kinetics; D008297:Male; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D011311:Pressoreceptors / Q000503:physiopathology*; D012039:Regional Blood Flow; D014628:Vagotomy
D010100:Oxygen