Concentration of cefuroxime in cerebrospinal fluid in patients with bacterial meningitis.
10 adults with bacterial meningitis were given 1.5 g cefuroxime intravenously 4 time daily in addition to the normal antibiotic treatment. CSF levels of cefuroxime ranged from 1.5 to 13.5 mg/l (mean 6.0 mg/l) in the aucte stage of the disease. In the convalescent stage, the cefuroxime levels in the CSF varied from less than 1 to 7.5 mg/l (mean 3.2 mg/l). The CSF levels of cefuroxime in all but one measurement, by far exceeded the MIC values reported for the vast majority of strains of the pathogen commonly associated with meningitis.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002444:Cefuroxime / Q000134:cerebrospinal fluid* / Q000627:therapeutic use; D002511:Cephalosporins / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008581:Meningitis / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D008875:Middle Aged
D002511:Cephalosporins; D002444:Cefuroxime