title: Release of betamethasone 17-valerate from extemporaneous dilutions of a proprietary topical  cream.
abstract: Six different vehicles for topical use were used to prepare 50% dilutions of Betnovate (betamethasone 17-valerate, 0.1%) cream. Blanching assessment as undertaken immediately after preparing the various dilutions and at 1 and 3 months thereafter. Few statistically significant differences were noted between any of the preparations tested indicating hat the rate of release of betamethasone 17-valerate is relatively unaffected by dilution. All preparations were assayed by a stability indicating high pressure liquid chromatographic technique for corticosteroid content. A diminution in the content of betamethasone 17-valerate in the E45 dilution was found 14 months after preparation. All other formulations tested were found to comply with label claim specifications.
mesh_terms: D000287:Administration, Topical; D001623:Betamethasone / Q000031:analogs & derivatives; D001624:Betamethasone Valerate / Q000008:administration & dosage; D001681:Biological Assay; D055598:Chemical Phenomena; D002621:Chemistry; D004355:Drug Stability; D005260:Female; D006801:Humans; D008297:Male; D014677:Pharmaceutical Vehicles
chemical_list: D014677:Pharmaceutical Vehicles; D001623:Betamethasone; D001624:Betamethasone Valerate