Effect of various vehicles and vehicle volumes on oral absorption of triamterene in rats.
The oral bioavailability of triamterene in rats was investigated after its administration as a suspension in lipid and aqueous vehicles in addition to lactic acid solution. Triamterene is poorly soluble in both aqueous and lipid vehicles. A 1-ml oral dose volume showed that lipid vehicles may provide some enhancement of oral availability compared with aqueous suspensions. However, when the vehicle volume was reduced to a realistic dosage form volume for the rat, peanut oil and aqueous suspensions were indistinguishable from each other with respect to peak height, peak time, and overall bioavailability. For a given vehicle small vehicle volumes resulted in a better relative oral availability than did large vehicle volumes.
D000818:Animals; D001682:Biological Availability; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D014677:Pharmaceutical Vehicles / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014223:Triamterene / Q000008:administration & dosage* / Q000378:metabolism
D014677:Pharmaceutical Vehicles; D014223:Triamterene