6'-N-methylfortimicins A and B and 6',6'-di-N-methylfortimicins A and B.
Selective 6'-N-alkylation of 1,2'-di-N-benzyloxycarbonylfortimicin B was effected by both catalytic and chemical reductive alkylation in the presence of aldehydes. These facile selective 6'-N-alkylations were used as the basis of the preparations of the 6',6'-di-N-methylfortimicins A and B, and the 6'-N-methylfortimicins A and B. Of these new 6'-N-methylated fortimicins, only 6'-N-methylfortimicin A has appreciable antibacterial activity, which was about half that of fortimicin A.
D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004352:Drug Resistance, Microbial; D008745:Methylation
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C032355:6'-N-methylfortimicin B; C032357:6'-di-N-methylfortimicin B; C032354:6'-N-methylfortimicin A; C032356:6'-di-N-methylfortimicin A