title: The dose-response effects of nifedipine of ST-segment changes in exercise testing: preliminary studies.
abstract: This study examines the effects of increasing doses of nifedipine on exercise-induced ST-segment depression in patients with severe typical stable angina pectoris. 10 patients underwent four 1-week treatment periods in a single-blind clinical trial. These were nifedipine 0, 30, 60, and 90 mg in divided doses daily. At the end of each week a maximum exercise test was performed using 16 precordial electrocardiographic leads and the ST-segment changes measured immediately after exercise. In 4 patients nifedipine produced no effects on these electrocardiographic parameters; 4 patients improved and 2 deteriorated. Thus, a dose of nifedipine, effective in 1 patient, can have opposite effects in another.
mesh_terms: D000787:Angina Pectoris / Q000188:drug therapy / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005080:Exercise Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*
chemical_list: D011725:Pyridines; D009543:Nifedipine