Uterine stimulant action of some omega-chain modified (+)-11-deoxyprostaglandins.
Rat uterine stimulant activity has been determined in vivo for a series of (+)-11-deoxyprostaglandins. The most active members of the series. 11-deoxy-15 methyl-PGE1, 11-deoxy-16,16-dimethyl - PGE1 and its 1-alcohol were 2-3 times more potent than PGE1. Gastrointestinal side effects assessed by the antagonism of morphine-induced constipation in the mouse, were generally relatively low with these compounds and consequently several members of the series had a more favourable relative selectivity than 16,16-dimethyl-PGE2 methyl ester.
D000818:Animals; D003248:Constipation / Q000139:chemically induced; D006224:Cricetinae; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D008186:Luteolytic Agents; D008297:Male; D051379:Mice; D009020:Morphine / Q000037:antagonists & inhibitors; D011465:Prostaglandins, Synthetic / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014590:Uterine Contraction / Q000187:drug effects*
D008186:Luteolytic Agents; D011465:Prostaglandins, Synthetic; D009020:Morphine