The metabolism of 1,3-dibromopropane by the rat.
1. The metabolism of 1,3-dibromopropane had been investigated in the rat. Two conjugated metabolites have been isolated from the urine and identified as S-(3-hydroxypropyl)cysteine and N-acetyl-S-(3-hydroxypropyl)cysteine. 2. An oxidation product, identified as beta-bromolactic acid, has been isolated as a urinary metabolite. 3. 1,3-dibromopropane is not excreted unchanged in expired air or in the urine. Approx. 15% of the dose (100 mg/kg) is excreted as metabolic products over 50 h and 3.5% as CO2 within 6 h, indicating that oxidation is the main route of detoxication.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001711:Biotransformation; D001965:Bromides / Q000652:urine; D004231:Diuresis / Q000187:drug effects; D006029:Glycosuria / Q000139:chemically induced; D008297:Male; D011407:Propane / Q000031:analogs & derivatives* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D001965:Bromides; D011407:Propane; C032699:1,3-dibromopropane