[Effect of thyrocalcitonin on the contraction and relaxation of the isolated myocardium in metabolic blockade and acidosis].
Thyrocalcitonine did not produce any effect on the contraction and relaxation of the thin papillary muscles of guinea-pigs, but restored reduced indices of the thick muscles function. The effect of the hormone was most expressed at a high contraction rate. The hormone also stopped reduction in the amplitude of the contractions or partly restored it under the action of metabolic inhibitors--2.4-dinitrophenol or 2-deoxyglucose as well as under the action of acidosis (pH-6.9). A positive inotropic effect of the hormone, that manifest itself under the conditions of a reduced amplitude of contractions is evidently realized through the influence on the Ca++--Na+ metabolism in cells and physiologically grounded, since it favours the stabilization of the myocardial contractility under hypocalcemia.
D000138:Acidosis / Q000503:physiopathology*; D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology; D004140:Dinitrophenols / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D010210:Papillary Muscles / Q000187:drug effects; D013997:Time Factors
D004140:Dinitrophenols; D002116:Calcitonin; D003847:Deoxyglucose
Vliianie tirokal'tsitonina na sokrashchenie i rasslablenie izolirovannoĭ serdechnoĭ myshtsy pri metabolicheskoĭ blokade i atsidoze.