Malignant hyperthermia syndrome.
Malignant hyperthermia is a pharmacogenetic disease involving uninhibited flow of calcium ion into the muscle substance. This leads to a combined metabolic and respiratory acidosis and the liberation of heat. If not immediately controlled, cellular death results. We treated a 4-year-old girl who suffered a malignant hyperthermia crisis during strabismus surgery. Hyperventilation with 100% oxygen and intravenously administered dantrolene sodium, furosemide, and fluids controlled the attack and the child recovered completely.
D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000008:administration & dosage; D002675:Child, Preschool; D003620:Dantrolene / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008305:Malignant Hyperthermia / Q000628:therapy*; D010102:Oxygen Inhalation Therapy; D013285:Strabismus / Q000601:surgery
D002121:Calcium Channel Blockers; D003620:Dantrolene; D002118:Calcium