Polydipsia and abolition of angiotensin-induced drinking after transections of subfornical organ efferent projections in the rat.
Rats with transections of subfornical organ (SFO) efferent projections failed to drink to intravenous angiotensin-II (AII) but responded to intracellular dehydration and water deprivation and suppressed drinking when food deprived. However, the transected rats were polydipsic and polyuric. Thus SFO efferent projections mediate AII-induced drinking and may be involved in the regulation of body fluid balance.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects; D004525:Efferent Pathways / Q000502:physiology; D005508:Food Deprivation; D008297:Male; D009490:Neurosecretory Systems / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013356:Subfornical Organ / Q000502:physiology*; D014868:Water Deprivation; D014882:Water-Electrolyte Balance / Q000187:drug effects
D000804:Angiotensin II