title: Arterial air embolism: structural effects on the gerbil brain.
abstract: Air injection into the carotid artery of adult mongolian gerbils caused, within 10 minutes, multifocal brain lesions. The extracellular spaces were widened and neurons, oligodendrocytes and myelin sheaths remained unchanged. The "delayed" effects of air embolism (first seen after 3 h) were similar to those observed in gerbils after unilateral carotid ligation. The histologic alterations after 3 h consisted of astrocytic swelling and shrinkage/necrosis of neuronal soma. The observations reported here illustrate the temporal and spatial separations that exist between a) brain water retention, and b) intraparenchymal entry of horseradish peroxidase. Both alterations can be a consequence of either decreased blood flow or arterial air embolism. Edema and protein leakage in each situation may be initiated by different mechanisms.
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001921:Brain / Q000473:pathology* / Q000648:ultrastructure; D004618:Embolism, Air / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005849:Gerbillinae; D006735:Horseradish Peroxidase / Q000378:metabolism; D008297:Male
chemical_list: D001798:Blood Proteins; D006735:Horseradish Peroxidase