[Significance of cytotoxic anti-brain antibodies in the blood in infantile cerebral palsy].
The results of examining the blood serum of 75 children aged up to 2 years suffering from infantile cerebral paralysis of various gravity, as well as the results of analogous examinations of 21 healthy children are presented. Use was made of the immunological tests of glia migration inhibition, and of complement fixation. It was shown that the results of both tests characterized the gravity of the disease. The glia migration inhibition tests (performed with the use of brain antigen) has made it possible to detect cytotoxic anticerebral antibodies in children with a mild, moderate, and grave degrees of the disease much more often than the complement fixation test. The rise of the titres of those antibodies was found to be in a certain correlation with the disease gravity and outcome. The data obtained were compared with the results of morphological examinations of the brain of serum-positive children. Prospects of using the glia migration inhibition test in combinations with clinical and morphological examinations for further studies of the pathogenesis of the infantile cerebral paralysis are discussed.
D001323:Autoantibodies / Q000032:analysis*; D001921:Brain / Q000276:immunology*; D002464:Cell Migration Inhibition; D002547:Cerebral Palsy / Q000175:diagnosis / Q000276:immunology*; D002675:Child, Preschool; D003168:Complement Fixation Tests; D006801:Humans; D007223:Infant; D008297:Male; D009457:Neuroglia / Q000276:immunology
D001323:Autoantibodies
O znachenii tsitotoksicheskikh protivomozgovykh antitel v krovi pri detskom tserebral'nom paraliche.