Parathyroid hormone effects on calcium metabolism in the rat are impaired by 5-ethyl-5'-(1-methylpropyl)-2-thiobarbiturate (inaktin).
The mechanism by which inaktin, a thiobarbiturate, promotes a moderate drop in serum calcium has been investigated. The effect was cancelled in hypocalcemic parathyroidectomized rats. On the other hand inaktin antagonized the serum calcium raising effects of parathyroid extract in these animals. In rats wit intact parathyroid glands inaktin caused a two-fold increase in urinary calcium excretion and a marked decrease in body and bone calcium turnover (measured with 45 Ca). These results support the view that inaktin impairs the parathyroid hormone effects on calcium metabolism.
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D008297:Male; D010280:Parathyroid Glands / Q000502:physiology; D010281:Parathyroid Hormone / Q000037:antagonists & inhibitors* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013874:Thiopental / Q000031:analogs & derivatives* / Q000494:pharmacology
D000777:Anesthetics; D010281:Parathyroid Hormone; C004316:thiobutabarbital; D013874:Thiopental; D002118:Calcium