Telemetry of cardiac left ventricular pressure in conscious dogs.
A fully implantable telemetric system for the measurement of cardiac left ventricular pressure and derived parameters in conscious dogs is presented. It provides the following advantages: ethical acceptability, scientific relevance, economical experimentation, avoidance of stress-induced situations for the animal, experiments without anaesthesia or sedation. The system has an operation time which allows the sequential pharmacological evaluation of a great number of drugs in individual dogs as has been shown by testing the effect of the positive inotropic agent, dobutamine, and the calcium antagonists, verapamil and nifedipine.
D000818:Animals; D004280:Dobutamine / Q000494:pharmacology; D004285:Dogs; D006352:Heart Ventricles / Q000187:drug effects; D009200:Myocardial Contraction; D009543:Nifedipine / Q000494:pharmacology; D011312:Pressure; D013686:Telemetry / Q000295:instrumentation*; D016276:Ventricular Function; D014700:Verapamil / Q000494:pharmacology
D004280:Dobutamine; D014700:Verapamil; D009543:Nifedipine