title: Urinary metabolites of oxapadol (MD720111), a new non-narcotic analgesic agent, in the rat, dog and man.
abstract: 1. A number of metabolites of oxapadol were isolated from urine of rat, dog and man after administration of a single dose of 14C-labelled compound. They were identified by direct inlet mass spectrometry and chromatographic comparison with reference compounds. 2. Oxapadol was extensively metabolized and the unchanged drug was undetectable in rat or human urine; only traces were found in dog urine. Nine metabolites were identified in rat and dog urine, and six in man. 3. The routes of biotransformation were: (a) aromatic hydroxylation, mainly in the benzimidazole ring, (b) scission of the heterocyclic ring following two different pathways, and (c) a combination of the two. Regioselectivity was observed for aromatic hydroxylation, as only three of the four possible monohydroxy oxazepinobenzimidazoles could be detected.
mesh_terms: D000328:Adult; D000700:Analgesics / Q000652:urine*; D000818:Animals; D001381:Azepines / Q000378:metabolism*; D001562:Benzimidazoles / Q000378:metabolism*; D001711:Biotransformation; D004285:Dogs; D004355:Drug Stability; D005260:Female; D006801:Humans; D006868:Hydrolysis; D008297:Male; D010077:Oxazepines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
chemical_list: D000700:Analgesics; D001381:Azepines; D001562:Benzimidazoles; D010077:Oxazepines; C023515:oxapadol