Testicular hypoplasia in a bull with XX/XY chimerism.
A 4-year-old 1/2 Hereford X Bos indicus bull displayed XX/XY chimerism associated with arrested spermatogenesis. Phenotypic examination revealed underdeveloped dorsal neck muscles, a non-pendulous scrotum, testes firm in consistency and a scrotal circumference measurement of 27 cm. On rectal palpation, small seminal vesicles were present and only azoospermic seminal fluid was collected at 3 monthly electroejaculations. Chromosome analysis on 2 monthly batches of leukocyte cultures showed a mean chimeric ratio of 80% of XX:20% XY cells. Cells cultured from skin were all male. Histopathological examination of both testes revealed reduction in size and number of tubules, marked hypoplastic germinal epithelium showing only spermatogonia and a well defined interstitium with large quantities of collagen. The small size of the testes and histological changes were suggestive of a testicular hypoplasia.
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics*; D002678:Chimera; D007962:Leukocytes / Q000166:cytology; D008297:Male; D012729:Sex Chromosome Aberrations / Q000662:veterinary*; D013737:Testis / Q000002:abnormalities*