[Nephrotoxicity caused by amphotericin B].
A six-year-old child with coccidioidomycosis is reported. The patient was given amphotericin B, that brought about disturbances in renal function with renal failure, which turned reversible on discontinuance of treatment. The earliest manifestations of nephrotoxicity were observed following administration of a total dose of 1,000 mgs. The findings were: glycosuria, cylindruria, high urinary pH followed by metabolic acidosis, hypokalemia, decreased capacity of renal concentration and clearance of endogenous creatinine. Oral administration of postassium bicarbonate and interruption of amphotericin B were followed by reversal of kidney lesion manifestations.
D000141:Acidosis, Renal Tubular / Q000139:chemically induced; D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000188:drug therapy / Q000652:urine; D000666:Amphotericin B / Q000009:adverse effects* / Q000627:therapeutic use; D001639:Bicarbonates / Q000627:therapeutic use; D002648:Child; D003047:Coccidioidomycosis / Q000188:drug therapy; D003404:Creatinine / Q000097:blood; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced; D008297:Male; D017680:Potassium Compounds
D001639:Bicarbonates; D017680:Potassium Compounds; D000666:Amphotericin B; D003404:Creatinine; C026329:potassium bicarbonate
Nefrotoxicidad por anfotericina B.