title: Search for antitumor compounds. XIII. Biological studies. Antitumor properties of 20 quinolines, carbazoles, acridines nitro derivatives.
abstract: Results of the studies on antitumor activity of 20 acridines and related compounds (19 of them were new) in Sa-180-bearing mice are presented. Only several of these compounds i.e. C-258, C-829, C-874, and C-899(21) appeared to inhibit the Sa-180 growth; the activity of the two other compounds (C-783(21) and C-755(21)) requires confirmation in further experiments. The remaining 14 compounds were inactive. Some other general effects exerted by the compounds tested in Sa-180-bearing mice and some aspects of the structure-activity relationship are discussed.
mesh_terms: D000166:Acridines / Q000627:therapeutic use*; D000609:Aminoacridines / Q000627:therapeutic use; D000634:Aminoquinolines / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002227:Carbazoles / Q000627:therapeutic use*; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009574:Nitro Compounds / Q000627:therapeutic use*; D009600:Nitroquinolines / Q000627:therapeutic use*; D012513:Sarcoma, Experimental / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000166:Acridines; D000609:Aminoacridines; D000634:Aminoquinolines; D000970:Antineoplastic Agents; D002227:Carbazoles; D009574:Nitro Compounds; D009600:Nitroquinolines