Preliminary evidence that thrombin may mimic a naturally occurring proteinase in cultured cells.
A neutral proteinase has been purified from the membranes of human leukocytes. Antibodies to this enzyme inhibit its proteolytic activity, and inhibit the growth of cultured human fibroblasts. This growth inhibition is apparently reversed by added thrombin.
D000906:Antibodies; D000936:Antigen-Antibody Complex; D002455:Cell Division / Q000187:drug effects; D002462:Cell Membrane / Q000201:enzymology; D002478:Cells, Cultured; D006801:Humans; D007962:Leukocytes / Q000201:enzymology*; D013917:Thrombin / Q000378:metabolism* / Q000494:pharmacology
D000906:Antibodies; D000936:Antigen-Antibody Complex; D013917:Thrombin