Isolation and characterization of two new trichothecenes from Fusarium sporotrichioides strain M-1-1.
Two new trichothecenes were isolated along with T-2 toxin, neosolaniol, and HT-2 toxin from the culture filtrate of Fusarium sporotrichioides strain M-1-1. The structures of the new toxins were characterized to be 4 beta, 8 alpha-diacetoxy-12,13-epoxytrichothec-9-ene-3 alpha, 15-diol (designated NT-1) and 4 beta-acetoxy-12,13-epoxy-trichothec-9-ene-3 alpha,8 alpha,15-triol (designated NT-2).
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005670:Fusarium / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D009183:Mycotoxins / Q000302:isolation & purification* / Q000494:pharmacology; D014176:Protein Biosynthesis; D011817:Rabbits; D012156:Reticulocytes / Q000378:metabolism; D012717:Sesquiterpenes / Q000302:isolation & purification*; D014255:Trichothecenes / Q000302:isolation & purification* / Q000494:pharmacology
D009183:Mycotoxins; D012717:Sesquiterpenes; D014255:Trichothecenes; C032169:toxin NT-1; C032170:toxin NT-2