Effect of corticosterone on the plasma and tissue concentrations of vitamin A in rats.
The administration of large doses of corticosterone to normal adult male rats resulted in a rapid loss of vitamin A from the plasma, liver, adrenals and thymus. Of the organs studied, the thymus appeared to be the most sensitive to treatment. The steroid-mediated depression of plasma and tissue contents of vitamin A was reversed when animals were treated with corticosterone in combination with vitamin A.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003345:Corticosterone / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014801:Vitamin A / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology
D014801:Vitamin A; D003345:Corticosterone