Phentolamine therapy in severe chronic asthmatiform bronchitis.
Continuous phentolamine infusion for 3 days in 6 patients with severe chronic bronchial obstruction produced a marked improvement in subjective well-being and arterial blood gas values. Ventilatory function and pulmonary arterial pressure remained virtually unchanged but a chronic oral corticosteroid therapy could be substantially reduced during 4 weeks of oral treatment with phentolamine 100 mg three times daily.
D000328:Adult; D001158:Arteries; D001249:Asthma / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen; D010313:Partial Pressure; D010646:Phentolamine / Q000627:therapeutic use*; D011651:Pulmonary Artery; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D010100:Oxygen; D010646:Phentolamine