[Development of liver cirrhosis in rats following stimulation of hepatic macrophages].
Liver cirrhosis was induced in male Wistar rats weighing 200-250 g by subcutaneous injection of 0.25 ml of a 10% CCl4 solution per 100 g bw. Kupffer cells were stimulated with prodigiozan which was introduced at a 10-day interval in the course of fibrosis development. Under stimulation the injury to the parenchyma decreased; the total number of Kupffer macrophages and the degree of mononuclear infiltration of liver tissue increased, while fibroplasia diminished. The content of hydroxyproline in liver homogenates of prodigiozan-stimulated rats was half as much as compared with controls.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy*; D007728:Kupffer Cells; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008106:Liver Cirrhosis, Experimental / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use*; D011354:Prodigiozan / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013936:Thymidine / Q000378:metabolism
D011135:Polysaccharides, Bacterial; D011354:Prodigiozan; D000135:Acid Phosphatase; D013936:Thymidine
Osobennosti razvitiia tsirroza pecheni u krys pri stimuliatsii pechenochnykh makrofagov.