Bacterial conversion of phenylalanine and aromatic carboxylic acids into dihydrodiols.
Strain E of chloridazon-degrading bacteria, when grown on L-phenylalanine accumulates cis-2,3-dihydro-2,3-dihydroxyphenylalanine. In experiments with resting cells and during growth the bacterium converts the aromatic carboxylic acids phenylacetate, phenylpropionate, phenylbutyrate and phenyl-lactate into the corresponding cis-2,3-dihydrodiol compounds. The amino acids L-phenylalanine, N-acetyl-L-phenylalanine and t-butyloxycarbonyl-L-phenylalanine were also transformed into dihydrodiols. All seven dihydrodiols, thus obtained, were characterized both by conventional analytical techniques and by the ability to serve as substrates for a cis-dihydrodiol dehydrogenase.
D000596:Amino Acids / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism*; D002264:Carboxylic Acids / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D002942:Circular Dichroism; D006018:Glycols / Q000302:isolation & purification / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism; D010649:Phenylalanine / Q000378:metabolism*; D011724:Pyridazines / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet
D000596:Amino Acids; D002264:Carboxylic Acids; D006018:Glycols; D011724:Pyridazines; C005586:pyrazon; D010649:Phenylalanine; D010088:Oxidoreductases; C019872:chloridazondihydrodiol dehydrogenase