title: Evaluation of instrumented force platform as a test to measure residual effects of anesthetics.
abstract: Recovery from anesthesia was assessed in a controlled manner in 38 healthy student volunteers, using two psychomotor tests (perceptual speed and tapping board) and an instrumented force platform 1, 3, 5 and 7 h after intravenous injection of 0.3 mg/kg diazepam, 2.0 mg/kg methohexital, 6.0 mg/kg thiopental or saline. Postural stability remained unaltered but the performance on psychomotor tests improved when the tests were repeated after saline injection. Methohexital did not induce any changes in body sway or psychomotor performance at the time periods tested when compared with saline. Postural stability of subjects receiving thiopental or diazepam was imparied (P less than 0.001) for 1 and 7 hours after anesthesia, respectively, when compared with saline. The impairment on performance in the psychomotor tests induced by thiopental or diazepam was of smaller magnitude and for diazepam of shorter duration than balance disturbances measured with the body sway tests. Further clinical studies on the use of the instrumented force platform as a fast and easily interpretable guideline for discharge from hospital after different modes of outpatient anesthesia are warranted.
mesh_terms: D000328:Adult; D003975:Diazepam / Q000494:pharmacology*; D006801:Humans; D008723:Methohexital / Q000494:pharmacology*; D011187:Posture / Q000187:drug effects*; D011596:Psychomotor Disorders / Q000175:diagnosis; D013874:Thiopental
chemical_list: D008723:Methohexital; D013874:Thiopental; D003975:Diazepam