The separation and quantitation of the narcotic components of illicit heroin using reversed-phase high performance liquid chromatography.
The separation of heroin from other narcotic components of illicit preparations is achieved by high performance liquid chromatography. Using an aminopropyl bonded silica packing and a mixture of 85% acetonitrile and 15% 0.005 M tetrabutylammonium phosphate as the mobile phase, caffeine, heroin, acetylcodeine, 6-acetylmorphine, codeine, and morphine are separated from each other and are accurately quantified. Papaverine, noscapine, thebaine, and strychnine are also separated from these principal components.
D002110:Caffeine / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003061:Codeine / Q000302:isolation & purification; D005554:Forensic Medicine; D003932:Heroin / Q000302:isolation & purification*; D007880:Legislation, Drug; D009022:Morphine Derivatives / Q000302:isolation & purification; D009294:Narcotics / Q000032:analysis*; D006113:United Kingdom
D009022:Morphine Derivatives; D009294:Narcotics; D002110:Caffeine; D003932:Heroin; C026979:6-O-monoacetylmorphine; D003061:Codeine