The calcium carbimide-ethanol interaction: lack of relation between electroencephalographic response and cerebrospinal fluid acetaldehyde.
Penetration of acetaldehyde into cerebrospinal fluid (CSF) was studied in healthy human volunteers during calcium carbimide-ethanol interaction. CSF was sampled via lumbar puncture and blood from a cubital vein. CSF and blood acetaldehyde concentrations varied from 1 to 41 and from 22 to 138 mumol/l, respectively. The results indicate that acetaldehyde penetrates the human blood-liquor barrier. Computer analysis of electroencephalograms (EEGs) recorded during the interaction showed reduction in alpha activity with a concomitant increase in delta activity. The changes were similar to those previously observed during 'normal' ethanol intoxication.
D000079:Acetaldehyde / Q000097:blood / Q000134:cerebrospinal fluid*; D000328:Adult; D001921:Brain / Q000187:drug effects*; D003484:Cyanamide / Q000494:pharmacology*; D003486:Cyanides / Q000494:pharmacology*; D004347:Drug Interactions; D004569:Electroencephalography; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D007408:Intestinal Absorption; D008297:Male
D003486:Cyanides; D000431:Ethanol; D003484:Cyanamide; D000079:Acetaldehyde