The effect of non-phorbol promoters as compared with phorbol myristate acetate on sister chromatid exchange induction in cultured Chinese hamster cells.
The effect of 5 unrelated chemicals with different promoting potencies on sister chromatid exchange (SCE) induction in V79 cells was investigated. Two powerful promoters--12-O-tetradecanoylphorbol-13-acetate (TPA) and anthralin; a moderate promoter--iodoacetic acid (IAA); two weak promoters--ethyl phenylpropiolate (EPP) and cantharidin--all induced similar and low numbers of SCE. These results do not support the hypothesis that enhanced mitotic recombination is responsible for tumour promotion.
D000818:Animals; D000875:Anthralin / Q000633:toxicity; D002193:Cantharidin / Q000633:toxicity; D002273:Carcinogens / Q000633:toxicity*; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D003434:Crossing Over, Genetic / Q000187:drug effects*; D007461:Iodoacetates / Q000633:toxicity; D010704:Phorbols / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*
D002273:Carcinogens; D007461:Iodoacetates; D010704:Phorbols; D002193:Cantharidin; D013755:Tetradecanoylphorbol Acetate; D000875:Anthralin