Pimozide attenuates acquisition of lever-pressing for food in rats.
Pimozide pretreatment produced a dose-dependent attenuation of acquisition of a lever-pressing habit motivated by food reward in hungry rats. No evidence of learning was seen in animals treated at 1.0 mg/kg, minimal learning was seen at 0.5 mg/kg, and retarded learning which ultimately did reach normal asymptote was seen at 0.25 mg/kg. Thus primozide attenuates the response acquisition function as well as the previously studied response maintenance function of food reward.
D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D003864:Depression, Chemical; D005502:Food; D008297:Male; D010868:Pimozide / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects
D011954:Receptors, Dopamine; D010868:Pimozide