Brain lesions in the paraventricular nuclei and catecholaminergic neurons minimize salt hypertension in Dahl salt-sensitive rats.
1. The rise in blood pressure in Dahl salt-sensitive rats that received intracerebroventricular 6-hydroxydopamine was almost half that of the control rats throughout 20 weeks of high (8%) NaCl feeding. 2. The rise in blood pressure in Dahl salt-sensitive rats with bilateral complete electrolytic lesions of the paraventricular nuclei was almost half that of the control rats during 12 weeks of high (8%) NaCl feeding. 3. The bilateral complete electrolytic lesions of the suprachiasmatic nuclei enhanced the development of NaCl hypertension in Dahl salt-sensitive rats. 4. These results show that NaCl-induced hypertension in Dahl salt-sensitive rats requires the integrity of the central nervous system catecholaminergic neurones and the paraventricular nuclei for its full expression.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000502:physiology*; D006973:Hypertension / Q000139:chemically induced* / Q000517:prevention & control; D007031:Hypothalamus / Q000502:physiology*; D009115:Muridae; D009897:Optic Chiasm / Q000502:physiology; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology*; D012965:Sodium Chloride / Q000009:adverse effects*; D013495:Supraoptic Nucleus / Q000502:physiology
D002395:Catecholamines; D012965:Sodium Chloride