Leukaemic liver infiltration in AKR mice prematurely induced by immunization with human or allogeneic liver protein.
An attempt was made to produce a model of autoimmune hepatitis in AKR mice by immunization with allogeneic liver extract or a purified (human) liver-specific lipoprotein (LSP). Although a mononuclear infiltrate was found in the liver in recipients of purified liver antigen and to a lesser degree in recipients of allogeneic extract, this was associated with the development of an acute thymus-derived leukaemia. This mouse strain is normally susceptible to leukaemia after a latent period of approximately 6 to 9 months but the immunization schedule markedly reduced the age of onset of this disease.
D000818:Animals; D006520:Hepatitis, Animal / Q000276:immunology*; D006801:Humans; D007114:Immunization; D007942:Leukemia, Experimental / Q000209:etiology* / Q000473:pathology; D008099:Liver / Q000276:immunology / Q000473:pathology; D008297:Male; D008565:Membrane Proteins; D051379:Mice; D008806:Mice, Inbred AKR; D011506:Proteins / Q000276:immunology
D008565:Membrane Proteins; D011506:Proteins