Establishment of an albumin-deficient and jaundiced strain of rats.
An albumin deficient and jaundiced rat (AJR) strain was established from crosses between Albumin-Deficient rats (NAR) and jaundiced Gunn rats. AJRs have a double homozygous mutant trait (alb/alb, j/j), and systemic jaundice and various neurological signs are observed 5--7 days after birth, kernicterus occurs and they die within three weeks after birth. This strain of rats may serve as a model of human kernicterus and also be useful in elucidating the mechanism of bilirubin metabolism.
D000818:Animals; D001663:Bilirubin / Q000097:blood; D001947:Breeding; D005260:Female; D007565:Jaundice / Q000235:genetics / Q000662:veterinary*; D008297:Male; D051381:Rats; D011922:Rats, Mutant Strains / Q000235:genetics*; D012376:Rodent Diseases / Q000235:genetics*; D012709:Serum Albumin / Q000172:deficiency*
D012709:Serum Albumin; D001663:Bilirubin