Response of metastatic cloacogenic carcinoma to treatment with semustine.
A case of cloacogenic carcinoma of the anorectal junction with pulmonary metastases is presented. Treatment with Semustine (Methyl-CCNU) resulted in a partial response lasting 15 months. Cloacogenic carcinoma is an uncommon neoplasm against which only a few chemotherapeutic agents have been tried. Semustine should be considered in the treatment of metastatic cloacogenic carcinoma.
D001005:Anus Neoplasms / Q000473:pathology; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000556:secondary*; D008875:Middle Aged; D009607:Nitrosourea Compounds / Q000627:therapeutic use*; D012004:Rectal Neoplasms / Q000473:pathology; D012673:Semustine / Q000627:therapeutic use*; D013997:Time Factors
D009607:Nitrosourea Compounds; D012673:Semustine; D005472:Fluorouracil