Immunomodulators--thymus factor X (TFX) and levamisole in immune reactions and inflammatory processes.
Comparative evaluation of immunotropic and inflammatory activity of thymus factor (TFX) and levamisole was performed. In numerous experimental systems it was shown that both preparations exert stimulatory effect on the course and intensity of the specific immune reactions. Many tests proved their stimulatory effect on the nonspecifically induced inflammatory processes. TFX as well as levamisole, beside their influence on the course of immune reactions, are also active in the differentiation of T lymphocytes. Differences and similarities in the effect of both evaluated compounds were examined in the in vivo and in vitro systems and it was observed that levamisole possesses the components of activity atypical for thymus hormones.
D000818:Animals; D002403:Cathepsins / Q000378:metabolism; D006087:Graft vs Host Reaction; D006168:Guinea Pigs; D006461:Hemolysis / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects*; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology*; D007978:Levamisole / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009113:Muramidase / Q000097:blood; D010587:Phagocytosis / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013949:Thymus Extracts / Q000494:pharmacology*; D014374:Tuberculin Test
D013949:Thymus Extracts; D007978:Levamisole; D009113:Muramidase; D002403:Cathepsins