[Modification of hepatotoxic effect of halogenated hydrocarbons on partially hepatectomized rats (author's transl)].
The effect of hepatectomy on the hepatotoxic effect of halogenated hydrocarbons was studied. Male rats received oral administration of chloroform of carbon tetrachloride at a single dose of 500 mg/kg, 3 days prior to or after the partial hepatectomy. The hepatotoxic effect of the toxins was modified in a different manner according to the time of the hepatectomy. In the animals hepatectomized 3 days after the hepatotoxins administration, histological changes of the liver were similar to those of the non-hepatectomized rats, except with an increase in the activity of GOT and GPT. Contrary, in the animals hepatectomized 3 days prior to the hepatotoxins administration, the toxic effect of the chemicals was less enhanced than in the non-hepatectomized animals.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000503:physiopathology*; D006498:Hepatectomy; D006846:Hydrocarbons, Halogenated / Q000633:toxicity*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D006846:Hydrocarbons, Halogenated; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Modification de la toxicité hépatique des hydrocarbures halogénés chez les rats partiellement hépatectomisés.