Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis.
D001665:Binding Sites; D003460:Crystallization; D006877:Hydroxamic Acids; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D013820:Thermolysin / Q000378:metabolism*; D014961:X-Ray Diffraction; D015032:Zinc
D006877:Hydroxamic Acids; D013820:Thermolysin; D015032:Zinc