Hypomelanosis of Itô: a neurocutaneous syndrome.
A 2 1/2-year-old girl with hypomelanosis of Itô is described. There is a bizarre distribution of congenital depigmentation stopping abruptly at the midline anteriorly, with whorl-like and zig-zag patterning. As can happen in this syndrome, there is severe retardation and intractible epilepsy, with computerized tomography showing gross cerebral atrophy.
D002675:Child, Preschool; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000150:complications; D008548:Melanosis / Q000151:congenital* / Q000473:pathology; D009422:Nervous System Diseases / Q000150:complications*; D012867:Skin / Q000473:pathology; D013577:Syndrome