Studies on interactions of vitamin E with thiamine, niacin and vitamin B12.
The effects of simultaneous administration of thiamine, niacin or vitamin B12 with vitamin E on plasma vitamin E levels were studied in 20 adult male volunteers belonging to the low socio-economic class. The effect of vitamin E on the nutritional status of pyridoxine, riboflavin and thiamine as judged by the erythrocyte enzymes, aspartate aminotransferase, glutathione reductase and transketolase, respectively was also studied. None of the members of the B-complex vitamins studied here had any effect on plasma vitamin E levels. This was in contrast to the observation made earlier that pyridoxine and riboflavin can reduce plasma vitamin E. There was a transient reduction in both the basal and stimulated activities of erythrocyte aspartate aminotransferase, the significance of which needs further investigation.
D000328:Adult; D001219:Aspartate Aminotransferases / Q000097:blood; D004347:Drug Interactions; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D008297:Male; D009539:Nicotinic Acids / Q000494:pharmacology*; D011736:Pyridoxine / Q000494:pharmacology; D013831:Thiamine / Q000494:pharmacology*; D014174:Transketolase / Q000097:blood; D014805:Vitamin B 12 / Q000494:pharmacology*; D014810:Vitamin E / Q000008:administration & dosage / Q000097:blood*
D009539:Nicotinic Acids; D014810:Vitamin E; D005980:Glutathione Reductase; D014174:Transketolase; D001219:Aspartate Aminotransferases; D011736:Pyridoxine; D014805:Vitamin B 12; D013831:Thiamine