[Investigations on neurotoxicity of chemical substances at the workplace. II. Determination of the motor and sensory nerve conduction velocity in persons occupationally exposed to pentachlorophenol (author's transl)].
We examined eighteen workers (three women, 15 men) in a pentachlorophenol (PCP) processing factory, with a mean activity of 12 years. PCP in blood and urine samples was analyzed by gas chromatography. To evaluate the peripheral nervous system the maximal motor as well as sensory nerve conduction velocities of the ulnar and/or median nerve were measured. The PCP-levels in plasma ranged between 0.02 and 1.5 ng/l, median 0.25 ng/l, and in urine between 13 and 1,224 micrograms/l, median 112 micrograms/l, or between 11 and 2,111 micrograms/g creatinine, median 111 micrograms/g creatinine. The median values of the neurophysiological parameters showed a mild degree of slowing in the PCP-collective. In the case of the sensory nerve conduction velocities, this decrease was significant. A dose-effect relationship between internal PCP-load and the different nerve conduction velocities could not be demonstrated. The individual evaluation of the toxicological and neurophysiological results gave hints that in some cases decreased nerve conduction velocity is caused by chronic exposure to PCP.
D000328:Adult; D000375:Aging; D002733:Chlorophenols / Q000506:poisoning*; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000187:drug effects*; D009422:Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology; D009431:Neural Conduction / Q000187:drug effects*; D009475:Neurons, Afferent / Q000187:drug effects*; D009784:Occupational Diseases / Q000139:chemically induced / Q000503:physiopathology*; D010416:Pentachlorophenol / Q000506:poisoning*
D002733:Chlorophenols; D010416:Pentachlorophenol
Untersuchungen zur Neurotoxizität von Arbeitsstoffen. II. Messung der motorischen und sensorischen Nervenleitgeschwidigkeit bei beruflich Pentachlorphenol-belasteten Personen.