[Mechanism of the central effects of tropane].
The effect of tropan on exocellular-recorded electrical activity of brain sensorimotor cortical and ventrolateral thalamic neurons was studied in acute experiments on rabbits. Tropan was injected intravenously in a dose of 1-5 mg/kg and applied microiontophoretically to individual neurons. With both routes of administration tropan increased the frequency of spontaneous activity of the majority of cortical and thalamic neurons in the dose-dependent form. The inhibitory action of the microiontophoretically applied catecholamines noradrenaline and dopamine on the activity of brain cortical neurons does not change under the effect of tropan. The stimulatory effect of catecholamines on ventrolateral thalamic neurons is potentiated by tropan. It is suggested that excitation of cortical and subcortical neurons, as well as potentiation of stimulatory catecholaminergic effects in the subcortex underlie the central stimulant effect of tropan.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004298:Dopamine / Q000494:pharmacology; D004357:Drug Synergism; D009638:Norepinephrine / Q000494:pharmacology; D011817:Rabbits; D013003:Somatosensory Cortex / Q000187:drug effects*; D013788:Thalamus / Q000187:drug effects*; D014326:Tropanes / Q000494:pharmacology*
D014326:Tropanes; D004298:Dopamine; D009638:Norepinephrine
K mekhanismu tsentral'nykh éffektov tropana.