[Influence of various non-steroid antirheumatic drugs on the electric potential between the gastric serosa and mucosa (author's transl)].
Non-steroid antirheumatic drugs inhibit the synthesis of prostaglandin, which results in a reduction in the efficacy of the gastric mucosal barrier. The transmural electric potential difference of the stomach wall would appear to be a useful criterion for mucosal barrier function. After 4 weeks of treatment with Indomethacin, Azapropazpone, Diclofenac or Phenylbutazone, a significant reduction in the gastric potential difference as compared with the pre-treatment measurement was observed. Accordingly, non-steroid antirheumatics give rise to a reduction in the functional efficacy of the mucosal barrier.
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001032:Apazone / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004008:Diclofenac / Q000627:therapeutic use; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D008875:Middle Aged; D010653:Phenylbutazone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D004008:Diclofenac; D010653:Phenylbutazone; D001032:Apazone; D007213:Indomethacin
Einfluss verschiedener nicht-steroidaler Antirheumatika auf die elektrische Potentialdifferenz der Magenschleimhaut.