title: [Optimization of the nutrient medium composition for the biosynthesis of the antibiotic tobramycin using a mathematical experimental design method].
abstract: The mathematical design of the experiment was used for optimization of the nutrient medium for biosynthesis of tobramycin by Streptomyces cremeus var. tobramycini. The use of the orthogonal Latin rectangles provided development of the fermentation medium composition and definition of the optimal concentration of its ingredients. The level of tobramycin production on this medium was 2 times higher than that on the initial one.
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D003470:Culture Media / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005285:Fermentation; D008433:Mathematics; D012107:Research Design; D013302:Streptomyces / Q000378:metabolism; D014031:Tobramycin / Q000096:biosynthesis*
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media; D014031:Tobramycin
vernacular_title: Optimizatsiia sostava pitatel'noĭ sredy dlia biosinteza antibiotika tobramitsina s pomoshch'iu matematicheskogo metoda planirovaniia éksperimenta.