[Changes in the ploidies of hepatocyte nuclei of animals with transplantable tumors during liver regeneration and x-irradiation].
Alterations in ploidy of hepatocyte nuclei were followed in experiments on 190 rats with transplantable tumors during liver regeneration and x-ray irradiation. The presence of the growing transplantable tumor in the animal's body led to alterations in the nuclear structure of hepatocytes, manifesting in the increased ploidy. X-Ray irradiation brought about a rise in hepatocyte ploidy which was more remarkable the higher the dose. Under such conditions, polyploidy of hepatocyte nuclei was more pronounced in tumor-bearing rats than in those without tumors. An abrupt increase in ploidy of hepatocyte nuclei occurred in the regenerating liver of tumor-bearing animals both non-irradiated and, particularly, irradiated ones.
D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D005260:Female; D008099:Liver / Q000648:ultrastructure*; D008115:Liver Regeneration; D008297:Male; D009374:Neoplasms, Experimental / Q000235:genetics* / Q000532:radiotherapy / Q000648:ultrastructure; D011003:Ploidies; D051381:Rats; D012513:Sarcoma, Experimental / Q000235:genetics / Q000648:ultrastructure
Ob izmenenii ploidnosti iader gepatotsitov u zhivotnykh s perevivnymi opukholiami pri regeneratsii pecheni i rentgenovskom obluchenii.