Monoclonal antibodies directed against the human Leb blood group antigen.
Four monoclonal antibodies produced by hybridomas obtained from a mouse immunized with a human adenocarcinoma cell line SW1116 (Koprowski, H., Steplewski, Z., Mitchell, K., Herlyn, M., Herlyn, D., and Fuhrer, P. (1979) Somatic Cell Genet. 5, 957-972) are directed against the Leb antigen of the human Lewis blood group system. Their specificities were established by binding studies using purified Leb-active ceramide hexasaccharide and by hapten inhibition studies involving oligosaccharides obtained from human milk.
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002460:Cell Line; D003110:Colonic Neoplasms / Q000276:immunology; D006028:Glycosphingolipids / Q000276:immunology; D006801:Humans; D007700:Kinetics; D007983:Lewis Blood Group Antigens / Q000276:immunology*; D008545:Melanoma / Q000276:immunology; D009844:Oligosaccharides
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D006028:Glycosphingolipids; D007983:Lewis Blood Group Antigens; D009844:Oligosaccharides