Neuropharmacological actions of some newly synthesized Mannich bases.
Benzamido (alkyl) methyl pyrrolidine Mannich bases were synthetized and subjected to certain neuropharmacological studies. All the bases reduced the pentobarbitone sleeping time and rota-rod grip of rats. The Mannich bases II, III and V raised the minimal electro-shock seizure threshold of rats. The TAB-induced pyrexia was not reduced by the bases I and III in rabbits. None of the bases showed any significant analgesic activity.
D000588:Amines / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008352:Mannich Bases / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology; D004856:Postural Balance / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D011955:Receptors, Drug / Q000378:metabolism*; D012684:Sensory Thresholds / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D000588:Amines; D008352:Mannich Bases; D011955:Receptors, Drug; D010424:Pentobarbital