Food-induced increase in propranolol bioavailability--relationship to protein and effects on metabolites.
The influence of a meal on the disposition and metabolism of oral propranolol was examined in six normal subjects. The meal induced a mean 53% increase in propranolol bioavailability (range 2% to 92%; P less than 0.01) without affecting time to maximum concentration, half-life, or the amount of unchanges drug in urine. There was no effect on the plasma concentrations of 4-hydroxypropranolol or four other metabolites. The increased bioavailability was linearly related to the protein content of the meal (r = 0.884, P less than 0.02) above a threshold content of about 7 gm.
D000328:Adult; D001682:Biological Availability; D004044:Dietary Proteins / Q000008:administration & dosage*; D004435:Eating; D006207:Half-Life; D006801:Humans; D008297:Male; D011433:Propranolol / Q000031:analogs & derivatives / Q000378:metabolism*; D014018:Tissue Distribution
D004044:Dietary Proteins; C001422:4-hydroxypropranolol; D011433:Propranolol