Extrahepatic sites of metabolism of N-nitrosopyrrolidine in mice and rats.
1. By the use of whole-body autoradiography, the localization of N-nitroso[14C]pyrrolidine and its metabolites was demonstrated in the tissues of C57B1-mice and Sprague-Dawley rats. 2. On the basis of the autoradiographic data, tissues were selected and tested for their ability to metabolize N-nitroso[14C]pyrrolidinie to 14CO2 and tissue-bound metabolites. 3. The results indicated that only few tissues had a marked ability to degrade N-nitrosopyrrolidine. These were the liver and the nasal mucosa in both species, the tracheobronchial mucosa in mice, and to a lower extent the kidneys in both species.
D000818:Animals; D001345:Autoradiography; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009242:N-Nitrosopyrrolidine / Q000378:metabolism*; D009297:Nasal Mucosa / Q000378:metabolism; D009602:Nitrosamines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D014018:Tissue Distribution
D009602:Nitrosamines; D009242:N-Nitrosopyrrolidine