[Behavior of free amino acids in plasma and urine of intensive care patients with multiple injuries during the administration of an amino acid solution with 10% branched-chain amino acids].
The study was performed on eleven severely injured ventilated intensive care patients. Plasma and urine concentrations of free amino acids, nitrogen balance and energy expenditure were studied for a period of six days following trauma. Most of the free amino acids in plasma, especially the BCAA's return to reference range within a few days after trauma on administering the infusion solution investigated. An amino acid imbalance in the plasma of severely traumatized patients could be avoided by infusion of an amino acid solution containing only 10% branched-chain amino acids. The amino acids infused are utilized to an extent of more than 90%. However, a still markedly increased negative nitrogen balance, as well as a clearly negative energy balance indicate, that further investigations on nitrogen - and carbohydrate supply are necessary.
D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000378:metabolism*; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage*; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000378:metabolism; D011487:Protein Conformation; D014947:Wounds and Injuries / Q000378:metabolism*
D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D009584:Nitrogen
Verhalten der freien Aminosäuren im Plasma und im Urin polytraumatisierter Intensivpatienten unter Zufuhr einer Aminosäurenlösung mit 10% igem Gehalt verzweigtkettiger Aminosäuren.