Effect of D-penicillamine on liver glutathione.
D-penicillamine is believed to protect against liver injury induced by certain chemicals. This view is based on the assumption that penicillamine is a structural analogue of cysteine, methionine, and congeners which protect against liver injury, perhaps by preventing GSH depletion, and that penicillamine also prevents GSH depletion. Our data indicate on the other hand that penicillamine actually depletes GSH and in animals may predispose to rather than prevent hepatic damage.
D000818:Animals; D005978:Glutathione / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010396:Penicillamine / Q000494:pharmacology*; D011441:Propylthiouracil / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D011441:Propylthiouracil; D005978:Glutathione; D010396:Penicillamine