System of rabbit antigens which elicit skin-reacting transplantation antibodies and are different from RLA.
Relationship between the rabbit histocompatibility RLA system and antigens eliciting skin-reacting transplantation antibodies (SRTA) was studied. The rabbit sera obtained by alloimmunization with skin transplant were investigated in the dye-exclusion cytotoxic test with lymphocytes and in the skin test on a panel of the outbred rabbits. Basing on a pairwise analysis of reactions in the cytotoxic test, some of these sera were classified into three groups of significantly correlated anti-RLA 1, 2, 3 sera. Analysis of reactions in the skin test revealed two groups of significantly correlated sera different from anti-RLA 1, 2, 3, which were designated as anti-SA and anti-SB. All anti-SA and anti-SB sera were also examined in the agglutination test with a panel of red blood cells but none of them was capable of agglutination. Study on tissue distribution of RLA and antigens eliciting SRTA showed that both systems are shared by skin and lymphoid tissue but in the brain tissue only antigens eliciting SRTA were present.
D000818:Animals; D000906:Antibodies; D000941:Antigens; D001921:Brain / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006649:Histocompatibility Antigens / Q000276:immunology*; D008221:Lymphoid Tissue / Q000276:immunology; D008297:Male; D011817:Rabbits; D012867:Skin / Q000276:immunology*; D012882:Skin Tests
D000906:Antibodies; D000941:Antigens; D006649:Histocompatibility Antigens