title: The extent of histone acetylation induced by butyrate and the turnover of acetyl groups depend on the nature of the cell line.
abstract: Cells possessing widely different physiological and morphological features have been treated with substances known to stimulate the differentiation of erythroleukemia cells. Only short fatty acids are capable of causing a hyperacetylation of the core histones and of enhancing the level of an H1-like protein in Chinese hamster ovary cells. While the time courses of a butyrate-mediated acetylation are similar for all cells, the maximum histone acetyl contents are much higher for the transformed cell of a given type. A withdrawal of butyrate rapidly (within 45 min) gives rise to a 'hypoacetylated state' for fibroblasts and transformed fibroblast (epithelial) cells from which there is a slow recovery. Lymphoid cells, on the other hand, display a marked persistance of the highly acetylated forms of histone H4.
mesh_terms: D000107:Acetylation; D000818:Animals; D002087:Butyrates / Q000494:pharmacology*; D020148:Butyric Acid; D002264:Carboxylic Acids / Q000494:pharmacology; D002453:Cell Cycle; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D006224:Cricetinae; D003412:Cricetulus; D003998:Dicarboxylic Acids / Q000494:pharmacology; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D006657:Histones / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D007942:Leukemia, Experimental / Q000378:metabolism; D008297:Male; D010053:Ovary
chemical_list: D002087:Butyrates; D002264:Carboxylic Acids; D003998:Dicarboxylic Acids; D006657:Histones; D020148:Butyric Acid