Electrical properties of isolated demyelinated rat nerve fibres.
Isolated large rat nerve fibres with diphtheria toxin induced paranodal demyelination were investigated. These fibres had increased membrane time constant of the demyelinated nodal segment, related to a large increase in capacitance (5 to 50 times). The resting conductance was less increased (2 to 3 times), meaning that the internodal axolemma has considerably higher resting resistance than the nodal membrane. A large variation in action potential amplitude was found which was unrelated to the size of the nodal widening and the passive electrical properties.
D000200:Action Potentials; D000818:Animals; D003711:Demyelinating Diseases / Q000139:chemically induced; D004167:Diphtheria Toxin; D008564:Membrane Potentials; D009413:Nerve Fibers, Myelinated / Q000502:physiology*; D009431:Neural Conduction; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000187:drug effects
D004167:Diphtheria Toxin