Impaired leukocyte mobility and production of monocyte-derived granulotactic factor in pediatric malignant disease during chemotherapy.
Random mobility and chemotactic responses of granulocytes and monocytes, and production of monocyte-derived chemotactic factor for granulocytes (CFG) in the 17 patients with childhood malignant disease were estimated using an agarose plate method. Mononuclear cells (MNC) of the majority of the patients contained a significantly decreased number of monocytes with normal migratory capacity, whereas random mobility of granulocytes of all the patients was within normal range. Chemotactic responses of granulocytes and monocytes to zymosan activated serum (ZAS) were decreased in 11 to 17 occasions. All these impairments seemed to be induced by chemotherapeutic agents, because there were no differences in the degree of the impairment between group in remission with maintenance chemotherapy and that during induction chemotherapy.
D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects; D002465:Cell Movement; D002630:Chemotactic Factors / Q000096:biosynthesis*; D002634:Chemotaxis, Leukocyte; D002648:Child; D002675:Child, Preschool; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D009000:Monocytes / Q000276:immunology*; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology*
D000970:Antineoplastic Agents; D002630:Chemotactic Factors