Influence of 2,4-dinitrophenol on the susceptibility of rats to hepatotoxic injury.
Treatment of rats with 2,4-dinitrophenol (DNP) markedly enhanced the release of enzymes into serum induced by carbon tetrachloride (CCl4). DNP also aggravated the hepatotoxic response to paracetamol but not that to allyl alcohol, bromobenzene and thioacetamide. DNP-induced hypoxia resulting in an accelerated metabolic activation of CCl4 presumably accounts for the interaction between DNP and CCl4.
D019297:2,4-Dinitrophenol; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000503:physiopathology; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology*; D004140:Dinitrophenols / Q000633:toxicity*; D004798:Enzymes / Q000097:blood; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D004140:Dinitrophenols; D004798:Enzymes; D019297:2,4-Dinitrophenol