An interphase model for mitotic chromosome organization in eukaryota.
A model for the spatial relationship of the arrangement of the chromosomes in the nucleus in eukaryota is presented. Evidence is derived from light and electron microscopic studies, application of autoradiographic and banding techniques; on the organization, structure and behaviour of chromosomes during interphase and other stages of cell cycle. This model visualizes the entire chromosomal DNA as a single uninemic multirepliconic continuum where the chromosomes with their centromeres and telomeres have a predetermined arrangement among themselves as well as in relation to the nucleolus and nuclear membrane. This orderly arrangement is presumably maintained through interchromosomal connections. The impact of this model on the interpretation of various cytogenetic phenomena is discussed.
D000818:Animals; D002467:Cell Nucleus / Q000502:physiology; D002875:Chromosomes / Q000502:physiology* / Q000648:ultrastructure; D004261:DNA Replication; D008854:Microscopy, Electron; D008938:Mitosis; D008954:Models, Biological