[Osteosis deformans of thyroid origin. Radiological, histomorphometric and pathophysiological study (author's transl)].
A 73-year-old woman with severe, old standing thyrotoxicosis developed osteosis with deformities of the lower limbs and spine resembling osteomalacia. All the well-known radiological, and histomorphometric features of thyroid osteosis were caricaturally present in this patient who, in addition, exhibited curvatures of the lower limbs that are exceptionally described in hyperthyroidism. A study of standard phosphorus/calcium values, 25 OH D values, circulating parathyroid hormone levels and fractional absorption of 47Ca before and after thyroidectomy enables the authors to discuss the current pathophysiological concepts concerning phosphorus/calcium and bone metabolism in hyperthyroid conditions. A possible action of thyroid hormones on vitamin D metabolism or peripheral effects is envisaged.
D000368:Aged; D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications* / Q000378:metabolism; D007866:Leg / Q000000981:diagnostic imaging; D010018:Osteomalacia / Q000209:etiology; D010024:Osteoporosis / Q000209:etiology; D011859:Radiography; D013131:Spine / Q000000981:diagnostic imaging; D014807:Vitamin D / Q000378:metabolism
D014807:Vitamin D
Ostése thyroöidienne déformante. Etude radiologique, histomorphométrique et physiopathologique.