title: The intravenous toxicity of lentinan to the beagle dog.
abstract: The i.v administration of lentinan to the Beagle dog induced changes in the cytoplasm of macrophagic cells in the liver, spleen, kidney, lungs, lymph nodes, small intestine. Electron-lucent or filamentous inclusions were demonstrated in the liver, kidney and spleen. A dose level of 0.5 mg/kg/day was without adverse effect.
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D004285:Dogs; D005260:Female; D007275:Injections, Intravenous; D007912:Lentinan / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011134:Polysaccharides / Q000633:toxicity*; D013997:Time Factors
chemical_list: D011134:Polysaccharides; D007912:Lentinan