In vivo carbon-13 nuclear magnetic resonance studies of mammals.
Natural abundance carbon-13 nuclear magnetic resonances (NMR) from human arm and rat tissues have been observed in vivo. These signals arise primarily from triglycerides in fatty tissue. Carbon-13 NMR was also used to follow, in a living rat, the conversion of C-1-labeled glucose, which was introduced into the stomach, to C-1-labeled liver glycogen. The carbon-13 sensitivity and resolution obtained shows that natural abundance carbon-13 NMR will be valuable in the study of disorders in fat metabolism, and that experiments with substrates labeled with carbon-13 can be used to study carbohydrate metabolism in vivo.
D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D002244:Carbon / Q000378:metabolism*; D002247:Carbon Isotopes; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008112:Liver Glycogen / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008961:Models, Structural; D051381:Rats; D013997:Time Factors
D002247:Carbon Isotopes; D008112:Liver Glycogen; D002244:Carbon; D005947:Glucose