Form of cadmium in rat liver subcellular particle.
Cadmium chloride (CdCl2) was injected s.c., 1.5 mg Cd/kg body weight into female Wistar rats for 7 consecutive days. Liver tissue was subfractionated, and ca. 2% of Cd in the tissue was found in the mitochondria and lysosomes, respectively. A high proportion of Cd, in the solubilized mitochondria and lysosomes, was bound to metallothionein and a small amount was distributed to higher molecular weight fraction. Cd in liver mitochondria and lysosomes exists mainly in the form of metallothionein.
D000818:Animals; D002104:Cadmium / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000378:metabolism*; D008247:Lysosomes / Q000378:metabolism; D008668:Metallothionein / Q000032:analysis; D008930:Mitochondria, Liver / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000032:analysis
D002104:Cadmium; D008668:Metallothionein; D015032:Zinc