Lymphocyte blast transformation and antibody responses after vaccination with inactivated mumps virus vaccine.
Mumps antibody response and the development of cell-mediated immunity (CMI) to mumps antigen as assayed by the lymphocyte blast transformation method were studied after immunization with an inactivated mumps vaccine in seven sero-negative and ten sero-positive subjects. The transformation response of peripheral blood lymphocytes to mumps antigen generally appeared by 20 weeks post vaccination and reached levels found in sero-positive subjects years after mumps infection. There was no clear-cut correlation between the magnitude of blast transformation and antibody responses.
D000914:Antibodies, Viral / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D008213:Lymphocyte Activation; D009108:Mumps Vaccine / Q000276:immunology*; D009109:Mumps virus / Q000276:immunology*; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000276:immunology
D000914:Antibodies, Viral; D009108:Mumps Vaccine; D014613:Vaccines, Attenuated