title: Paraoxon increases the rate of synthesis of acetylcholinesterase in cultured muscle.
abstract: Acetylcholinesterase (AChE) activity of cultured chick embryonic pectoral muscle was significantly increased above control activity during recovery from brief treatments with paraoxon (O, O-diethyl-p-nitrophenyl phosphate), the anticholinesterase metabolite of parathion. Paraoxon also increased the rate of degradation of the enzyme, suggesting the higher AChE activity of paraoxon-treated cells was due to a stimulation of enzyme synthesis.
mesh_terms: D000110:Acetylcholinesterase / Q000096:biosynthesis*; D000818:Animals; D002642:Chick Embryo; D003513:Cycloheximide / Q000494:pharmacology; D007700:Kinetics; D009132:Muscles / Q000201:enzymology*; D009924:Organ Culture Techniques; D010261:Paraoxon / Q000494:pharmacology*
chemical_list: D003513:Cycloheximide; D000110:Acetylcholinesterase; D010261:Paraoxon