Polymorphic acetylation of sulfamethazine in a Nigerian (Yoruba) population.
1. Sulfamehtazine was administered orally to 165 Yoruba subjects (40 mg/kg body wt.). Free and acetylated sulfamethazine were determined in the 6 h urines. 2. The population frequency histogram for percentage of urinary acetylated sulfamethazine was bimodal, although not completely resolved. Slow acetylators constituted 45% of the population studied. 3. This Yoruba population did not differ statistically (P greater than 0.05) in this respect from the two major tribally distinct groups in Nigeria previously investigated.
D000107:Acetylation; D000328:Adult; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D009549:Nigeria; D010641:Phenotype; D013418:Sulfamethazine / Q000378:metabolism*
D013418:Sulfamethazine