title: Effect of oral propranolol on the anerobic threshold and maximum exercise performance in normal man.
abstract: The effect of propranolol on the anaerobic threshold was studied in six healthy male volunteers. The subjects exercised on a cycle ergometer in a progressive exercise test to exhaustion with propranolol or no drug. Power output was increased by 30 W ever 2 min. Propranolol caused a significant reduction of heart rate by 20-45 beats per minute at all power outputs. In light and moderate exercise, no differences in oxygen uptake, ventilation, or blood lactate were observed in the propranolol and no-drug tests. The anaerobic threshold was not different between the no-drug (2.32 +/- 0.19 L O2/min, mean +/J- SD) and the propranolol (2.83 +/- 0.27 L O2/min) test; however, the heart rate at the anaerobic threshold was significantly lower in the propranolol (143 +/- 13 beats per minute) than the no-drug (187 +/- 9 beats per minute) tests. Above the anaerobic threshold, oxygen uptake was similar at a given power output but it reached a lower peak value (p less than 0.02) in the propranolol (3.16 +/- 0.16 L O2/min) versus the no-drug (3.64 +/- 0.39 L O2/min) tests. It was concluded that propranolol caused no change in anaerobic threshold in this specific progressive exercise protocol. The results suggest that a training intensity for endurance exercise bases on the anaerobic threshold does not need to be modified for subjects on propranolol medication.
mesh_terms: D000328:Adult; D000693:Anaerobiosis / Q000187:drug effects*; D006339:Heart Rate; D006801:Humans; D007773:Lactates / Q000097:blood; D008297:Male; D008660:Metabolism / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects*; D010806:Physical Education and Training; D005082:Physical Exertion / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology*
chemical_list: D007773:Lactates; D011433:Propranolol