Moloney virus (M-MuLV) leukemogenesis: virus spread, antibody production and antigenic expression in neonatally virus-inoculated young mice.
(A X C57BL) and (A X C57L)F1 hybrid mice were inoculated neonatally with M-MuLV. Virus spread, antigenic expression and antibody production were followed during the preleukemic period. M-MuLV was first detectable in the spleen and later in the thymus. Virus spread was faster and the level of viremia higher in A X C57L than in A X C57BL mice. Also, A X C57L mice had no or only low titers of virus neutralizing antibodies, whereas A X C57BL mice had high titers. Anti-MCSA antibodies, reacting with the surface of syngeneic M-MuLV-induced lymphoma cells, were present in a minority of the mice, but disappeared ultimately in all mice. The two groups of mice differed with regard to the length of the preleukemic latency period. High virus load and a low level of virus neutralizing and anti-MCSA antibodies were correlated with an earlier onset of leukemia.
D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D005260:Female; D007942:Leukemia, Experimental / Q000276:immunology / Q000382:microbiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008979:Moloney murine leukemia virus / Q000276:immunology / Q000302:isolation & purification; D011289:Preleukemia / Q000382:microbiology; D013997:Time Factors; D014779:Virus Replication
D000914:Antibodies, Viral; D000956:Antigens, Viral