Enhancement of responsiveness of the central serotonergic system and serotonin-2 receptor density in rat frontal cortex by electroconvulsive treatment.
The effect of a series of 10 electroconvulsive shocks (ECS) on the hyperthermic response of heat-adapted rats to a serotonergic stimulant, 3-chlorophenylpiperazine (CPP), and on radioligand binding to serotonin-1 and serotonin-2 receptors in frontal cortical membranes was investigated. Chronic ECS augmented the hyperthermic response of rats to CPP, did not affect [3H]serotonin binding to serotonin-1 receptors, and increased [3H]spiroperidol binding to serotonin-2 receptors. The treatment increased the density of serotonin-2 receptors by about 40%. It is suggested that the increased responsiveness of the central serotonergic system may be an important factor in the antidepressant action of chronic ECS.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D004597:Electroshock; D006358:Hot Temperature; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism
D010879:Piperazines; D011985:Receptors, Serotonin; D012701:Serotonin; C015068:1-(3-chlorophenyl)piperazine