title: Enzyme studies with human and hen autopsy tissue suggest omethoate does not cause delayed neuropathy in man.
abstract: Levels of acetylcholinesterase and neurotoxic esterase were measured in brain autopsy material. In tissue from a fatal human poisoning and from hens given 4-8 x unprotected LD50 AChE was highly inhibited and neurotoxic esterase uninhibited. The findings correlate with the inhibitory power of omethoate against these enzymes in vitro. It is concluded that omethoate has negligible potential to cause delayed neuropathy and a published report of human neuropathy due to omethoate is criticised.
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000328:Adult; D000818:Animals; D001921:Brain / Q000201:enzymology; D002091:Butyrylcholinesterase / Q000378:metabolism; D002645:Chickens; D004117:Dimethoate / Q000031:analogs & derivatives* / Q000506:poisoning / Q000633:toxicity; D005260:Female; D006801:Humans; D007306:Insecticides / Q000506:poisoning / Q000633:toxicity*; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology
chemical_list: D007306:Insecticides; C002302:dimethoxon; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D004117:Dimethoate