Effect of indomethacin on intestinal tumors induced in rats by the acetate derivative of dimethylnitrosamine.
Over the course of 20 weeks, Sprague-Dawley rats developed intestinal tumors in response to an intraperitoneal injection of the acetate derivative of dimethylnitrosamine. The same agent did not induce tumors in Lobund-Wistar rats. The number of tumors was significantly smaller in rats given drinking water containing indomethacin (beginning 14 days after the injections) than in control rats given drug-free water.
D000818:Animals; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D007213:Indomethacin / Q000494:pharmacology*; D007414:Intestinal Neoplasms / Q000139:chemically induced*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D004128:Dimethylnitrosamine; D007213:Indomethacin