Glial cell growth-promoting factor in astrocytoma (C6) cell extracts.
The presence of glia maturation factor (GMF)-like activity was demonstrated in rat astrocytoma cells (C6 cells). The extracts of C6 cells enhanced the DNA synthesis of cultured glioblasts 3-fold at the maximum, inducing such morphological changes as extrusion of processes. C6 cells also showed a proliferative response to the extracts, though the responsiveness in terms of effective concentration of C6 extracts was about a half of the glioblast responsiveness. The extracts lowered growth rate of neuroblastoma cells and especially decreased their DNA synthesis without a morphological differentiation.
D000818:Animals; D001254:Astrocytoma / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D002478:Cells, Cultured; D002999:Clone Cells; D004273:DNA, Neoplasm / Q000096:biosynthesis; D020904:Glia Maturation Factor; D005910:Glioma / Q000378:metabolism; D008938:Mitosis / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D051381:Rats; D014020:Tissue Extracts
D004273:DNA, Neoplasm; D020904:Glia Maturation Factor; D009419:Nerve Tissue Proteins; D014020:Tissue Extracts