The effect of RES blockade on red blood cell survival.
The effect of RES blockade on the survival of heat-damaged and antibody coated red blood cells was evaluated in C3H mice. RES function of C3H mice was determined by the survival of 59Fe-labeled, heat-damaged red blood cells at 49 degrees C for 30 min. When animals were treated with an intravenous injection of non-labeled, heat-damaged red blood cells for the blockade of RES, red blood cell destruction was depressed in non-splenectomized and splenectomized mice. In the survival or organ distribution of 59Fe-labeled, antibody-coated red blood cells, no difference was noted between animals with and without blockade. These findings suggest that heat-damaged red blood cells were destructed predominantly in the splenic RES and antibody coated cells were not broken down only by the splenic RES.
D000818:Animals; D002470:Cell Survival; D004912:Erythrocytes / Q000502:physiology*; D007501:Iron / Q000097:blood; D007700:Kinetics; D008099:Liver / Q000502:physiology; D051379:Mice; D008809:Mice, Inbred C3H; D012157:Mononuclear Phagocyte System / Q000502:physiology*; D009928:Organ Specificity; D013154:Spleen / Q000502:physiology; D013696:Temperature
D007501:Iron