title: Treatment of neonatal osteomyelitis with cloxacillin in combination with fusidic acid.
abstract: Four immature infants developed staphylococcal neonatal osteomyelitis. In spite of standard treatment with cloxacillin, gentamicin and surgical drainage new lesions developed in all 4 patients. Following the addition of fusidic acid no further progress was seen in any of the infants. Fusidic acid was administered intravenously for 10-14 days in a dose of 40 mg/kg/day in 2 divided doses. The therapy was well tolerated. Thoracic kyphosis in one patient was the only sequelae seen.
mesh_terms: D003023:Cloxacillin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005672:Fusidic Acid / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy*; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy*; D012306:Risk
chemical_list: D005672:Fusidic Acid; D003023:Cloxacillin