Desmosines in human urine. Amounts in early development and in Marfan's syndrome.
Desmosines from 24 h human urine samples were isolated, characterized and quantified. The desmosines are in peptidyl form (1000--1500 molecular weight), and their amount is decreased by two-thirds between 7 and 25 years of age. Patients with Marfan's syndrome have significantly lower urinary amounts of desmosines than do comparable controls during the early development period.
D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D002850:Chromatography, Gel; D003895:Desmosine / Q000031:analogs & derivatives / Q000652:urine*; D005260:Female; D006128:Growth; D006801:Humans; D008297:Male; D008382:Marfan Syndrome / Q000652:urine*; D010455:Peptides / Q000652:urine
D000596:Amino Acids; D010455:Peptides; D003895:Desmosine