Effect of intrauterine administration of antiprostaglandin drugs on implantation in the rat.
Three antiprostaglandin drugs, acetylsalicylic acid, indomethacin and ibuprofen, were administered intraluminally at different does to pregnant rats on Day 4 of pregnancy. It was observed that ibuprofen administered at a dose of 400 micrograms inhibited implantation in all rats. Ibuprofen when administered at a lower dose of 100 or 200 micrograms on Day 4 of pregnancy or at a dose of 400 micrograms on Day 3 or 5 of pregnancy did not exert such an antiimplantation effect. Acetylsalicylic acid and indomethacin also induced, but to a lesser extent, an antiimplantation effect when administered at a dose of 400 micrograms on Day 4 of pregnancy.
D000818:Animals; D001241:Aspirin / Q000008:administration & dosage; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D007052:Ibuprofen / Q000008:administration & dosage; D007213:Indomethacin / Q000008:administration & dosage; D007267:Injections; D011247:Pregnancy; D011448:Prostaglandin Antagonists / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D013997:Time Factors; D014599:Uterus
D011448:Prostaglandin Antagonists; D001241:Aspirin; D007052:Ibuprofen; D007213:Indomethacin