Clozapine effects on responding maintained under shock presentation and shock termination schedules.
Clozapine, a novel antipsychotic, was studied in different squirrel monkeys responding under a 3-min fixed-interval schedule of stimulus-shock termination and a multiple 5-min fixed-interval schedule of shock presentation, 5-min fixed-interval schedule of stimulus-shock termination. Some doses (0.1-1.0 mg/kg IM) of clozapine increased responding under each fixed-interval schedule, whereas higher doses (3.0 and 5.6 mg/kg IM) usually decreased responding under each schedule. Lower response rates maintained under the stimulus-shock termination schedule were increased relatively more by clozapine than were higher rates of responding maintained under the fixed-interval schedule of shock-presentation. The present results illustrate that the effects of clozapine on schedule-controlled behaviors of squirrel monkeys differ from those of other antipsychotics.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003024:Clozapine / Q000494:pharmacology*; D003984:Dibenzazepines / Q000494:pharmacology*; D004597:Electroshock; D008297:Male; D010775:Photic Stimulation; D012453:Saimiri
D003984:Dibenzazepines; D003024:Clozapine