Radionuclide assessment of extravascular lung water in minimal pulmonary oedema.
Extravascular lung water (EVLW) has been measured by a non-invasive technique using 123I-antipyrine and 113Indiumm-transferrin, as diffusible and non-diffusible indicators, and a gamma-camera computer system. Group A patients were normal radiologically and clinically. Group B patients were radiologically normal, clinically normal but were previously in heart failure and are currently on diuretics. Group C patients were radiologically normal, currently on diuretics with signs of pulmonary oedema. EVLW per unit blood flow and per unit blood volume were normal in groups A and B but raised in Group C patients. The peak height to equilibrium ratio of the 123I-antipyrine first pass curve was itself a useful discriminator in minimal pulmonary oedema.
D000983:Antipyrine / Q000378:metabolism; D001810:Blood Volume; D005110:Extracellular Space / Q000378:metabolism*; D006801:Humans; D007204:Indium; D007457:Iodine Radioisotopes; D008168:Lung / Q000098:blood supply / Q000000981:diagnostic imaging*; D008875:Middle Aged; D011654:Pulmonary Edema / Q000000981:diagnostic imaging*; D011868:Radioisotopes; D011877:Radionuclide Imaging; D014168:Transferrin / Q000378:metabolism
D007457:Iodine Radioisotopes; D011868:Radioisotopes; D014168:Transferrin; D007204:Indium; D000983:Antipyrine