title: Natural anti-lymphoma activity in C57BL/6 mice: time course of appearance and nature of cytotoxic antibodies.
abstract: A survey of the appearance of natural antibodies in C57BL/6 mice, measured by a complement-dependent cytotoxicity test against syngeneic radiation leukemia virus-induced lymphoma, was performed. Activity could be detected in sera from 5- to 14-month-old animals. This activity could be attributed mainly to IgM antibodies until the age of 10 months, whereas an increasing level of IgG-like antibodies was demonstrated in sera from 12-month-old mice.
mesh_terms: D000375:Aging; D000818:Animals; D000912:Antibodies, Neoplasm; D000917:Antibody Formation; D003602:Cytotoxicity, Immunologic; D007700:Kinetics; D007942:Leukemia, Experimental / Q000276:immunology; D007953:Leukemia, Radiation-Induced / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D011817:Rabbits; D013945:Thymoma / Q000276:immunology; D013997:Time Factors
chemical_list: D000912:Antibodies, Neoplasm