[Effects of 3-methylcholanthrene and 3-methylcholanthrene plus piracetam on the gamma-amino-butyric acid (GABA) content of several cerebral regions (author's transl)].
Chronic application of Piracetam decreases 3-methylcholanthrene-induced increased GABA content in the brains of rats and delays tumor appearance. The most active inhibitor of GABA-transaminase, amino oxyacetic acid (AOAA), increases the GABA content in the brain and appears to increase the tumor rate in 3-MC rats. Despite some reservations in view of results derived from investigations of only two compounds (3-MC and Piracetam) we suppose that a relation exists between effects on central nervous system and peripheral carcinogenesis. We will try to support our hypothesis further by using other compounds influencing the GABA-content of the brain.
D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D001932:Brain Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D008748:Methylcholanthrene / Q000494:pharmacology*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000032:analysis*
D011760:Pyrrolidinones; D000625:Aminooxyacetic Acid; D005680:gamma-Aminobutyric Acid; D008748:Methylcholanthrene; D010889:Piracetam
Die Wirkung von 3-Methylcholanthren und 3-Methylcholanthren plus Piracetam auf den gamma-Aminobuttersäure(GABA)-gehalt einzelner Hirnregionen.