Chromosome breakage and sister chromatid exchange frequencies in scleroderma.
Peripheral lymphocytes from 3 scleroderma patients with systemic disease and from 3 normal controls were examined for frequencies of chromosomal aberration and sister chromatid exchange (SCE). Significant increases in the levels of chromosomal anomaly and SCE were found for all 3 patients. These results are discussed in terms of the diagnostic potential of SCE in scleroderma and the possible etiologic role of cytogenetic instability in this disease.
D000328:Adult; D002869:Chromosome Aberrations; D003434:Crossing Over, Genetic; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D012595:Scleroderma, Systemic / Q000235:genetics*; D012854:Sister Chromatid Exchange