Erythrocyte catechol-O-methyltransferase activity in psychotic twins.
Erythrocyte catechol-O-methyltransferase (COMT) activity was analyzed in 20 twin pairs, 6 monozygotic and 14 dizygotic, where one or both twins showed psychotic or prepsychotic symptoms. Fifteen of these pairs, 4 monozygotic and 11 dizygotic, were diagnosed as discordant for serious mental disturbance. The different psychotic states within twins did not seem to be associated with any difference in COMT activity.
D000328:Adult; D002394:Catechol O-Methyltransferase / Q000097:blood* / Q000235:genetics; D004200:Diseases in Twins; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D011618:Psychotic Disorders / Q000201:enzymology / Q000235:genetics*; D012559:Schizophrenia / Q000201:enzymology / Q000235:genetics; D013548:Sweden
D002394:Catechol O-Methyltransferase