Immunoglobulin E-rheumatoid factor in the serum of patients with rheumatoid arthritis, asthma, and other diseases.
A solid-phase radioimmunoassay was developed to detect immunoglobulin (Ig)E antibodies that bound to human IgG. IgE-rheumatoid factor activity was found in the serum of 18 of 20 patients with seropositive rheumatoid arthritis, 1 of 4 patients with seronegative rheumatoid arthritis, 3 of 32 patients with seronegative rheumatoid arthritis, 3 of 32 patients with asthma, and in 1 patient with hypocomplementemic vasculitis and iodide sensitivity. Immunopathologic implications of IgE-rheumatoid factor are discussed.
D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001249:Asthma / Q000276:immunology*; D001667:Binding, Competitive; D006801:Humans; D007154:Immune System Diseases / Q000276:immunology*; D007073:Immunoglobulin E / Q000032:analysis*; D007074:Immunoglobulin G / Q000276:immunology; D007164:Immunosorbents; D011863:Radioimmunoassay / Q000379:methods; D012217:Rheumatoid Factor / Q000032:analysis*
D007074:Immunoglobulin G; D007164:Immunosorbents; D007073:Immunoglobulin E; D012217:Rheumatoid Factor