Treatment of a patient with impaired renal function with gentamicin-PMMA-beads.
150 gentamicin-PMMA-beads were implanted (+ 160 mg gentamicin i.v. preop.) in a woman aged 73 years and with severely impaired kidney function. Frequent determination of gentamicin plasma concentrations and renal functions were possible. The plasma concentration reached a plateau at approx. 3 micrograms/ml. No accumulation of gentamicin in plasma occurred.
D058186:Acute Kidney Injury / Q000097:blood*; D000368:Aged; D005260:Female; D005839:Gentamicins / Q000097:blood / Q000627:therapeutic use*; D006622:Hip Prosthesis; D006801:Humans; D013530:Surgical Wound Infection / Q000097:blood / Q000188:drug therapy*
D005839:Gentamicins