Substituted imidazo[2,3-alpha]pyridine-2-carbamate anthelmintics.
Anthelmintic efficacies of a series of 6-substituted methyl imidazo[1,2-alpha]pyridine-2-carbamates were compared to similarly substituted benzimidazole-2-carbamates. With only one exception, methyl 6-benzoylimidazo[1,2-alpha]pyridine-2-carbamate, both classes of compounds exhibited similar activity vs. Nematospiroides dubius in mice. Preliminary screening indicated methyl 6-(1,2,2-trichloroethenyl)imidazo[1,2-alpha]pyridine-2-carbamate to be the most potent derivative in the series. However, evaluation in sheep indicated that its anthelmintic spectrum was inferior to methyl 6-(phenylsulfinyl)imidazo[1,2-alpha]pyridine-2-carbamate.
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D002219:Carbamates / Q000138:chemical synthesis / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D009349:Nematode Infections / Q000188:drug therapy; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology; D012756:Sheep; D013329:Structure-Activity Relationship
D000871:Anthelmintics; D001562:Benzimidazoles; D002219:Carbamates; D007093:Imidazoles; D011725:Pyridines; C008722:methyl 6-(1,2,2-trichloroethenyl)imidazo(1,2-a)pyridine-2-carbamate