Several heat-sensitive properties of the MULv-induced YAC lymphoma.
A therapeutic heat dose of 44.0 +/- 0.1 degrees C/20 min caused either temporary or permanent inhibition of tumor growth in 86% (25/29) of the CAF1/J female mice inoculated in the footpad with MULv-induced YAC lymphoma and heated when the tumor was well established. Heating before the tumor is well established is less effective because the heat-sensitivity of the tumor increases as it grows in the host. The transplantability of this tumor is more effectively impaired when heated tumor tissue is left in situ for 24 h post-heating than if it is excised immediately after heating and implanted in host mice.
D000818:Animals; D005260:Female; D006358:Hot Temperature / Q000627:therapeutic use*; D007942:Leukemia, Experimental / Q000628:therapy*; D008223:Lymphoma / Q000628:therapy*; D051379:Mice; D008979:Moloney murine leukemia virus; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000628:therapy; D014184:Transplantation, Homologous