The binding of benzo[a]pyrene to mouse and rat skin DNA.
The covalently bound products of[3H]benzo[a]pyrene (BP) were determined in the DNA from the skin of mice and rats. While the total binding to DNA of rat skin is 3 times less than the DNA of mouse skin, the quality and the distribution of bound products was similar. The formation of (7R)-N2-[10-(7beta, 8alpha, 9alpha-trihydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene)yl] deoxyadenosine ((7R)BPDE I-dA) adduct was found.
D000818:Animals; D001580:Benzopyrenes / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000378:metabolism*; D012878:Skin Neoplasms / Q000139:chemically induced
D001580:Benzopyrenes; D004247:DNA