Disposition of hydrochlorothiazide (Hct) during phenytoin (Ph) treatment.
Plasma levels and urinary recovery of Hct were determined in seven healthy male volunteers. 75 mg Hct were administered as a tablet in a randomised fashion with or without phenytoin pretreatment (300 mg/d). Bioavailability of Hct showed considerable intra- and interindividual variation (32--87% and 42--77% respectively), but phenytoin did not influence the disposition parameters of the diuretic.
D000328:Adult; D001682:Biological Availability; D006801:Humans; D006852:Hydrochlorothiazide / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects*; D008875:Middle Aged; D010672:Phenytoin / Q000627:therapeutic use*
D006852:Hydrochlorothiazide; D010672:Phenytoin