[Changes in the state of plasma membrane proteins of tumor cells exposed to a polyene antibiotic and cyclophosphamide].
The fractional composition of the proteins of the plasmatic membranes of the Ehrlich's tumor cells treated with various drugs was studied with the use of electrophoresis in polyacrylamide gel. It was shown that the character of the changes in the fractional composition of the plasmatic membrane proteins under the effect of levorin and cyclophosphamide was different. When the drugs were used in combination, summation of the changes induced by every drug alone was observed. Possible causes of the changes in the fractional composition of the membrane proteins are discussed.
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D002174:Candicidin / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000032:analysis* / Q000188:drug therapy; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D008565:Membrane Proteins / Q000032:analysis*; D051379:Mice; D009363:Neoplasm Proteins / Q000032:analysis*
D000935:Antifungal Agents; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D002174:Candicidin; D003520:Cyclophosphamide
Izmenenie sostoianiia belkov plazmaticheskikh membran opukholevykh kletok pod vozdeĭstviem polienovogo antibiotika i tsiklofosfana.