title: The fate of oxalic acid in the Wistar rat.
abstract: 1. An established procedure for determining oxalate in human urine has been modified for rat urine. The daily excretion of oxalate by the male Wistar rat is 570-650 microgram. 2. Oxalate excretion in rat urine following i.p. administration of [14C]oxalic acid (1-70 mg/kg) has been studied. The rate and degree of excretion are dose-dependent. 3. The excretion of urinary oxalate by the rat has been quantified after administration of two oxalate-producing xenobiotics, alpha-chlorohydrin and 1,2-dibromo-3-chloropropane. 4. Oxalate inhibits the metabolism of glucose and lactate by isolated rat kidney tubules in vitro.
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D002728:Chlorohydrins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000378:metabolism; D006846:Hydrocarbons, Halogenated / Q000494:pharmacology*; D007684:Kidney Tubules / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010070:Oxalates / Q000378:metabolism* / Q000652:urine*; D019815:Oxalic Acid; D011407:Propane / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D000517:alpha-Chlorohydrin / Q000494:pharmacology*
chemical_list: D000969:Antinematodal Agents; D002728:Chlorohydrins; D006846:Hydrocarbons, Halogenated; D010070:Oxalates; D000517:alpha-Chlorohydrin; C007318:1,2-dibromo-3-chloropropane; D019815:Oxalic Acid; D005947:Glucose; D011407:Propane