Dopamine receptor in anterior byssus retractor muscle of Mytilus edulis.
Effects of dopamine, N-methyl-, ethyl- and propyl-derivatives of dopamine, and alpha- and beta-adrenoceptor stimulants on catch contraction of anterior byssus retractor muscle of Mytilus edulis were tested. The test drugs except the beta-adrenoceptor stimulants relaxed catch contraction. Dopamine was most active and substitution of amino group in dopamine with ethyl and propyl decreased activity considerably. The concentration-curves of dopamine, its derivatives and norepinephrine shifted in parallel with application of haloperidol but were not influenced by the alpha- and beta-adrenoceptor antagonists. These results suggest that relaxation of catch contraction by catecholamines is mediated through a dopamine receptor. This muscle is considered to be suitable for a study of the dopamine receptor.
D000818:Animals; D049872:Bivalvia; D004298:Dopamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D009119:Muscle Contraction / Q000187:drug effects*; D011941:Receptors, Adrenergic / Q000502:physiology; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*
D011941:Receptors, Adrenergic; D011954:Receptors, Dopamine; D004298:Dopamine