title: Connective tissue changes in surgically overloaded muscle.
abstract: The effects of overload on the connective tissue component of the soleus muscle of the rat have been investigated. Three weeks after tenotomy of its synergistic muscles the soleus underwent considerable increase in weight. This was shown to have resulted from an increase in size of the predominant fibre type. Whilst occasional groups of fibres appeared to have resulted from the splitting of large single fibres, there was not significant increase in the number of fibres in cross-section of the muscle belly. The connective tissue content of the overloaded muscles was investigated using both histological and biochemical techniques. It was found that muscle fibre hypertrophy was accompanied by an increase in the connective tissue component. Furthermore, there was an increase in the proportion of collagen to muscle fibre tissue.
mesh_terms: D000818:Animals; D003094:Collagen / Q000032:analysis; D003238:Connective Tissue / Q000503:physiopathology*; D008297:Male; D009132:Muscles / Q000503:physiopathology / Q000601:surgery*; D051381:Rats
chemical_list: D003094:Collagen