[Assessment of the potential risk for progeny in work with endodan (experimental studies)].
An experimental assessment was made on endodan (ETM) effect, dithiocarbamate preparation, on the reproductive function of the parent generation albino rats, perorally intoxicated (by a sound) with doses 1/10 and 1/100 LD50, daily in the course of 6 months (LD50 = 380 mg/kg). The postnatal development of the three successive generations (F1, F2, F3) was studied. For that purpose, a complex of integral toxicological methods was used: weight, neurobehavioural activity, nortality (by 1st, 5th, 21st day), with the calculation of the indices of survival and lactation, and fertility with calculation of the indices of fertility and gestation and biochemical and clinical laboratory methods for the assessment of the functional state of liver, brain and testes. The embryotoxic and teratogenic activity of endodan was assessed with a single (175 and 70 mg/kg, administered on the 9th, 11th and 13th day) and repeated (daily 70 and 35 mg/kg) peroral administration in the course of gestation. The routine teratological methods were used: number of yellow bodies, number of implantation with resorption autolysis and living fetuses, structural anomalies; assessment of the state of the internal organs (Wilson) and the skeletal system (Dowson). A test for dominant lethality was used for the evaluation of the mutagenic effect, under the conditions of subacute experiment. As a result a light gonadotropic effect was found (single deviations in the early postnatal development of the progeny, light teratogenic and mutagenic activity). The authors drew conclusions concerning the relatively higher perspectives of that dithiocarbamate preparation for the practice as regards the potential risk of the population. Consideration given to its higher dermal toxicity and cumulation effect, confirmed with the previous investigations and the total toxicological characteristic of dithiocarbamate, they stressed upon the necessity of the strictest observation of the hygienic standards and rules of safe work.
D000818:Animals; D002219:Carbamates; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D005799:Genes, Dominant / Q000187:drug effects; D005804:Genes, Lethal / Q000187:drug effects; D006540:Herbicides / Q000633:toxicity*; D008297:Male; D009153:Mutagens; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D012306:Risk; D013723:Teratogens; D013844:Thiazoles / Q000633:toxicity*
D002219:Carbamates; D006540:Herbicides; D009153:Mutagens; D013723:Teratogens; D013844:Thiazoles; C010145:ethylene thiuram monosulfide
Otsenka na potentsialniia risk za pokolenieto pri rabota s endodan (eksperimentalni prouchvaniia).