Rectal diazepam in the treatment of absence status: a pharmacodynamic study.
Rectal administration of diazepam is highly effective in terminating absence status as judged by reduction of spike-wave activity in the EEG. Pharmacokinetic studies indicate that diazepam can have antiepileptic properties at serum levels well below those previously reported as being necessary to achieve a therapeutic effect.
D000328:Adult; D003975:Diazepam / Q000008:administration & dosage* / Q000097:blood; D006801:Humans; D008297:Male; D012007:Rectum; D012996:Solutions; D013226:Status Epilepticus / Q000188:drug therapy*; D013488:Suppositories; D013997:Time Factors
D012996:Solutions; D013488:Suppositories; D003975:Diazepam