title: [Latent and exertion cardiac insufficiency--an indication for nitrates].
abstract: In order to prove the efficacy of the long-term nitrate pentaerythrityltetranitrate (PETN; Pentalong) in latent and stress heart insufficiency (causes ischaemic heart disease and/or hypertension) we examined 18 patients with this vasodilator with monotherapy as well as with digoxin combinations. Under PETN the symptoms of the clinical degree of severity could be clearly improved. Before and after stress the tension index showed a significant increase in the region of sufficiency. The sums of stress and recreation pulse and the mean arterial pressure proved a trend to decrease. The load tolerance on the bicycle ergometer was improved. Under the additional therapy with the fully effective dose of digoxin (dilanacin) with regard to the symptoms, load tolerance and partly also to pulse sums a deterioration of the parameters could be recognized in comparison to the PETN-monotherapy; only the combination with the half digoxin saturation does yielded more favourable results of the pulse sums. Apparently the treatment of patients with latent and stress heart insufficiency with long-term nitrates is an alternative to the therapy with glycosides and is even possibly superior to this.
mesh_terms: D000328:Adult; D003327:Coronary Disease / Q000150:complications; D004077:Digoxin / Q000627:therapeutic use; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D010417:Pentaerythritol Tetranitrate / Q000627:therapeutic use*; D005082:Physical Exertion; D011674:Pulse
chemical_list: D010417:Pentaerythritol Tetranitrate; D004077:Digoxin
vernacular_title: Latente und Belastungsherzinsuffizienz -- eine Indikation für Nitrate.