title: [Sensitivity of Candida spp. to 5-fluorocytosine, amphotericin B and imidazoles. Antifongiogram of 120 strains isolated at the Vaudois University Hospital Center during the autumn-winter seasons of 1978 and 1980].
abstract: 120 strains of Candida spp were tested against the antifungal agents 5-fluorocytosine, amphotericine B and the imidazoles econazole, miconazole and clotrimazole. The proportion of resistance varied with the species and substances: Candida albicans (100 strains): 4% resistance against 5-fluorocytosine, 1% against amphotericine B, no resistance to imidazoles; Candida tropicalis and C. pseudotropicalis (15 strains): 26.7% resistance to 5-fluorocytosine, 7.1% against amphotericine B, no resistance to imidazoles; Candida krusei (5 strains): no resistance to the antifungal agents. The correlation between the diameter measurements carried out at 2 dose levels of 5-fluorocytosine (1 and 100 micrograms) and of econazole (20 and 30 micrograms) was studied statistically and the validity of the experimental data established.
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy*; D003596:Cytosine / Q000031:analogs & derivatives*; D005437:Flucytosine / Q000627:therapeutic use*; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008826:Microbial Sensitivity Tests; D013045:Species Specificity
chemical_list: D007093:Imidazoles; D000666:Amphotericin B; D003596:Cytosine; D005437:Flucytosine
vernacular_title: Sensibilité de Candida spp à la 5-fluorocytosine, à l'amphotéricine B et aux imidazoles. Antifongigramme de 120 souches isolées au Centre Hospitalier Univesitaire vaudois (CHUV) pendant la période automne-hiver 1979-1980.