title: A correlative study of the restorative effects of endogenous and exogenous hormones on the leydig cells, the testis and the epididymis of the regressed hedgehog. Effects of hormones on hedgehog Leydig cells.
abstract: The study of the effects of morphogenesis at puberty on the Leydig cells in the testis of the young hedgehog and of the subsequent changes due to the seasonal varisations, has been done. Furthermore, the restorative changes induced by the exogenous hormones in the Leydig cells and the related sex organs of the regressed hedgehogs have also been studied. It was observed that the Leydig cells from the undifferentiated mesenchyme cell-like nature in the young hedgehog, develop into an adult form possessing large number of lipids, a well-developed Golgi apparatus, complex mitochondria and extensive smooth endoplasmic reticulum. The depletion of the lipids and other regression associated changes are found in the interstitial Leydig cells but not in those situated under tunica albuginea and the latter probably function as lipid storing cells during regression. Pituitary extract, either alone or in combination, but not testosterone, could restore completely the structure of the regressed Leydig cells. Similarly, the restoration of the complete process of spermatogenesis and the structure and function of the epididymis in the regressed hedgehog was found to be dependent upon the synergistic action of both testosterone and the gonadotrophic hormones.
mesh_terms: D000818:Animals; D004822:Epididymis / Q000187:drug effects / Q000502:physiology*; D006364:Hedgehogs / Q000502:physiology*; D007985:Leydig Cells / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D008297:Male; D010902:Pituitary Gland / Q000502:physiology*; D012621:Seasons; D012671:Seminiferous Tubules / Q000166:cytology / Q000502:physiology; D012741:Sexual Maturation; D013737:Testis / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D013739:Testosterone / Q000494:pharmacology*; D014020:Tissue Extracts / Q000494:pharmacology*
chemical_list: D014020:Tissue Extracts; D013739:Testosterone