title: The association of bacteriuria and reduced serum pyridoxal concentrations in patients with diabetes mellitus.
abstract: Of 1017 patients admitted to the Royal Perth Hospital Diabetic Survey 142 were found to have significant bacteriuria. In these bacteriuric patients serum pyridoxal concentrations were significantly reduced (P = less than 0.001) when compared with 142 diabetic patients matched for age (+/- 5 years) and sex but without infection of the urinary tract. Measurements were repeated up to 6 mth after antibacterial treatment and serum pyridoxal concentrations were still low. Pyridoxal has a role in immunological competence, and it is possible that the increased incidence of urinary tract infection in patients with diabetes reflects impaired immunological competence due to pyridoxal deficiency.
mesh_terms: D001419:Bacteria / Q000302:isolation & purification; D001437:Bacteriuria / Q000209:etiology* / Q000382:microbiology; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000276:immunology*; D006801:Humans; D011730:Pyridoxal / Q000097:blood* / Q000172:deficiency; D014552:Urinary Tract Infections / Q000209:etiology
chemical_list: D011730:Pyridoxal