The effect of mebendazole on sheep hydatid cysts as demonstrated by electron microscopy.
The ultrastructural changes induced in hydatid cysts from lungs of sheep after medication with one or two courses of mebendazole (Ovitelmin), each lasting 3 wk, are described. The hydatid germinal membrane tissue collected from the treated sheep showed complete degeneration of the tegumental and subtegumental structures and minor degree of calcification. Lung hydatid cysts of the untreated sheep presented normal ultrastructural configurations.
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D004444:Echinococcosis, Hepatic / Q000469:parasitology / Q000662:veterinary*; D004445:Echinococcosis, Pulmonary / Q000469:parasitology / Q000662:veterinary*; D004446:Echinococcus / Q000648:ultrastructure; D005260:Female; D008463:Mebendazole / Q000494:pharmacology*; D012756:Sheep; D012757:Sheep Diseases / Q000469:parasitology*
D001562:Benzimidazoles; D008463:Mebendazole