Characterization of the response of a human breast carcinoma cell line (T-47D) to radiation and chemotherapeutic agents.
The response of a human breast carcinoma cell line (T-47D) to various antitumor agents, gamma irradiation, UV light and heat was studied, using the colony-forming ability technique. Combinations of radiation with drugs and heat were also tested. The resulting survival curves corresponded to one of five patterns: simple exponential, biphasic exponential, threshold exponential, exponential plateau and ineffectual. Whereas the cells were particularly sensitive to gamma irradiation, the response to UV light was normal. The patient from whom this cell line originated did not respond to Methotrexate therapy. The in vitro results correlated with this observation.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D002460:Cell Line; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays / Q000627:therapeutic use; D006358:Hot Temperature / Q000627:therapeutic use; D006801:Humans; D066298:In Vitro Techniques; D014467:Ultraviolet Therapy
D000970:Antineoplastic Agents