Influence of ethyl alcohol on carcinogenesis with N-nitrosodimethylamine.
This paper presents the results of an experiment on the combined action of nitrosodimethylamine and ethyl alcohol in C57BL mice. As shown, alcohol can act to change the target organ of that liver carcinogen by favouring development of olfactory neuroepitheliomas, which infiltrate the frontal lobe of the brain.
D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000556:secondary; D003043:Cocarcinogenesis; D004128:Dimethylnitrosamine / Q000633:toxicity*; D004338:Drug Combinations; D004347:Drug Interactions; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D005625:Frontal Lobe; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008223:Lymphoma / Q000139:chemically induced; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000139:chemically induced* / Q000473:pathology / Q000556:secondary; D009669:Nose Neoplasms / Q000139:chemically induced* / Q000473:pathology
D004338:Drug Combinations; D000431:Ethanol; D004128:Dimethylnitrosamine