Experimental infection of the guinea pig inner ear with Toxoplasma gondii.
Based on the question whether toxoplasma gondii is a potential pathogenetic factor in sudden deafness and vertigo (especially in the acquired form of Toxoplasmosis) we started a series of investigations, dealing with direct, local, hematogenous, and intracisternal infection of the guinea pig cochlea with toxoplasma gondii. Three of ten directly inoculated and one of five hematogenously infected guinea pigs showed a severe labyrinthitis in electron and light microscopy. Thus, we could demonstrate that toxoplasma gondii is a potent pathogenetic factor in acute inner ear disturbances in laboratory animals. Toxoplasmosis should always be considered in cases with sudden deafness and vertigo without obvious other cause. With a specific therapy the labyrinthine disturbances can apparently be successfully treated.
D000818:Animals; D003051:Cochlea / Q000473:pathology; D007758:Ear, Inner / Q000473:pathology; D006168:Guinea Pigs; D007759:Labyrinth Diseases / Q000382:microbiology*; D007762:Labyrinthitis / Q000382:microbiology* / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D009925:Organ of Corti / Q000473:pathology; D014122:Toxoplasma / Q000472:pathogenicity; D014124:Toxoplasmosis, Animal / Q000382:microbiology* / Q000473:pathology; D014774:Virulence