Mitogenicity of influenza hemagglutinin glycoproteins and influenza viruses bearing H2-hemagglutinin.
The hemagglutinin glycoprotein is responsible for the mitogenic effect of influenza A viruses of the H2N2 subtype. This was indicated by the ability of viruses bearing the H2-hemagglutinin glycoprotein, regardless of its associated neuraminidase, to induce lymphocyte proliferation in normal spleen cell suspensions and by the ability of antisera with specificity for the H2-hemagglutinin to block this response. Moreover, purified hemagglutinin from representative viruses from the H0N1, H1N1, H2N2, H3N2, and influenza B subtypes were also shown to be mitogenic.
D006023:Glycoproteins / Q000494:pharmacology; D006389:Hemagglutinins, Viral; D009980:Influenza A virus / Q000276:immunology*; D008213:Lymphocyte Activation; D008934:Mitogens; D009975:Orthomyxoviridae / Q000276:immunology*; D014764:Viral Proteins / Q000494:pharmacology
D006023:Glycoproteins; D006389:Hemagglutinins, Viral; D008934:Mitogens; D014764:Viral Proteins