Synthesis, spectral behaviour and microbiological properties of some di(nitrothienyl)sulfides.
Six novel di)nitrothienyl)sulfides (I)-(VI) have been prepared either by condensation of suitable bromonitrothiophene derivatives with sodium sulfide or by hydrolysis of di-(3-nitro-2-thienyl)disulfide (XI), with ethanolic potassium hydroxide, followed by condensation of the resulting nitrothiophene thiolate with the appropriate bromonitrothiophenes. All compounds proved active, in vitro, against a number of gram-positive bacteria, at very low concentrations. Substitution of a thiophene nucleus by the benzene nucleus resulted in a decrease of activity. I.R. and U.V. spectral data are discussed.
D000900:Anti-Bacterial Agents / Q000032:analysis / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013440:Sulfides / Q000138:chemical synthesis / Q000494:pharmacology; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D009574:Nitro Compounds; D013440:Sulfides; D013876:Thiophenes