Antagonistic effect of sodium ascorbate on ethanol-induced changes in swimming of mice.
Swimming behavior in the mouse was used to study the motor disturbances induced by alcohol, and the effects of vitamin C upon these disturbances were assessed. High doses of vitamin C (125 and 500 mg/kg) prevented any swimming impairment due to ethanol; however, lower doses of vitamin C (62.5 mg/kg) had no significant effect. When given 1 h before alcohol, the protective effect of vitamin C was reduced. The alcohol-induced intoxication lasted beyond alcohol's elimination from the blood, suggesting that the intoxication is maintained by a metabolite of ethanol or by an effect of ethanol, or a metabolite, on another metabolic system.
D000079:Acetaldehyde / Q000494:pharmacology; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D000431:Ethanol / Q000037:antagonists & inhibitors* / Q000097:blood; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D013550:Swimming
D000431:Ethanol; D000079:Acetaldehyde; D001205:Ascorbic Acid