title: Synthesis of 6-substituted thymine nucleosides.
abstract: The preparation of several N(1)-glycosyl derivatives of 6-fluorothymine is described. The displacement of the fluorine atom at the C-6-position of the heterocyclic component lead to a series of new 6-substituted 5-methyl-pyrimidine-2,4-dione-nucleosides. Some of these new compounds show significant virostatic activity against influenza A virus strains.
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical; D007668:Kidney; D013936:Thymidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013941:Thymine / Q000031:analogs & derivatives*
chemical_list: C032448:6-fluorothymine; D013941:Thymine; D013936:Thymidine