Fine pathology of mouse spinal cord infected with the Tyzzer organism.
After intraspinal inoculation in mice, Tyzzer organisms were shown to grow within neurons resulting in degeneration and destruction of the host cells. Intraneuronally parasitising organisms were located within the cytoplasmic matrices or nuclear chromatin granules, and host cell organelles were disarranged or decreased in number seemingly by movement of bacterial peritrichous flagella. Axonal as well as myelin degeneration occurred in the white matter, and demyelination seemed to be in consequence of the axon damage due to intraxonal growth of organisms. Some organisms were present within cytoplasmic matrices of oligodendroglia cells and also within phagosomes of macrophages without active intracellular growth.
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D001407:Bacillus; D001424:Bacterial Infections / Q000473:pathology / Q000662:veterinary*; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D008854:Microscopy, Electron; D009474:Neurons / Q000648:ultrastructure; D012376:Rodent Diseases / Q000473:pathology*; D013116:Spinal Cord / Q000382:microbiology / Q000648:ultrastructure; D013118:Spinal Cord Diseases / Q000473:pathology / Q000662:veterinary*