Sister chromatid exchange in lymphoma line and lymphoblastoid cell lines before and after heterotransplantation into nude mice.
The sister chromatid exchange (SCE) rates of cell lines derived from patients with different malignant and premalignant disease were studied before and after intracerebral inoculation into nude mice and were compared to the SCE frequencies of cell lines from healthy controls. Lymphoma lines characterized by chromosomal markers as well as chromosomally normal lymphoblastoid cell lines were used. The SCE frequencies of nude mouse tumor-derived cell lines did not show a homogeneous pattern. They were either as high as, or higher or lower than, the SCE levels of the original cell line. But all cell lines, karyotypically abnormal as well as normal, originating from patients with malignant and premalignant diseases, showed significantly higher SCE rates than the control lines from healthy donors.
D000328:Adult; D000818:Animals; D002460:Cell Line; D002648:Child; D003434:Crossing Over, Genetic; D006689:Hodgkin Disease / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D008214:Lymphocytes / Q000166:cytology; D008223:Lymphoma / Q000235:genetics*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D012854:Sister Chromatid Exchange; D014183:Transplantation, Heterologous