[Mechanism of action of antiepileptic drugs].
The effect of anticonvulsants and tranquilizers on the initiation and spreading of convulsive discharges in rats, as well as on the spontaneous pacemaker activity and the effects of orthodromal stimulation in mollusc neurons are studied. It was found that the anticonvulsants acted mainly on the initiation of the epileptic discharge due to their influence on the mechanisms of endoneuronal rhythms. Diphenin inhibited simultaneously the initiation and the spreading of the convulsive discharge, the spontaneous activity of the neurons, and the responses to orthodromal stimulation. The tranquilizers and suxilep were found to influence only the spreading of the epileptic activity; the tranquilizers did not block the neuronal pacemaker activity and corasol-induced discharges. The authors recommend using the data obtained for choosing antiepileptic combinations in clinical conditions.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001463:Barbiturates / Q000494:pharmacology; D001550:Benzamidines / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects*; D002707:Chlordiazepoxide / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D005724:Ganglia / Q000187:drug effects*; D008140:Lorazepam / Q000494:pharmacology; D008297:Male; D008974:Mollusca; D010634:Phenobarbital / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology; D051381:Rats
D000927:Anticonvulsants; D001463:Barbiturates; D001550:Benzamidines; C018961:hexamidine; D010672:Phenytoin; D002707:Chlordiazepoxide; D008140:Lorazepam; D003975:Diazepam; C002915:benzobarbital; D010634:Phenobarbital
O mekhanismakh deĭstviia protivoépilepticheskikh sredstv.