Echovirus type 7 meningitis in young children.
Clinical and virological features are presented of an epidemic of aseptic meningitis in children caused by echovirus type 7. The majority of patients were younger than 1 year of age. Symptoms varied according to age. The degree of CSF pleocytosis was inversely related to age and was significantly greater in infants 7 months of age and younger than in those older than 7 months. A CSF polymorphonuclear pleocytosis was documented in 66% of the cases. Human placental fibroblast provided a more rapid detection of cytopathic effect and improved final recovery rates when compared with rhesus monkey kidney cells, Vero cells, and human epidermoid (Hep-2) cells. Several possible explanations for the sudden appearance of echovirus type 7 activity are discussed.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D004457:Echovirus Infections / Q000175:diagnosis / Q000382:microbiology*; D029822:Enterovirus B, Human / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008581:Meningitis / Q000382:microbiology*; D008582:Meningitis, Aseptic / Q000175:diagnosis / Q000382:microbiology*; D008587:Meningitis, Viral / Q000175:diagnosis / Q000382:microbiology*; D012189:Retrospective Studies