The effects of Danazol on the female genital tract of the rat.
The effects of Danazol on the reproductive organs of female rats have been investigated. Danazol brings about suppression of ovarian weight and distinct follicular atresia indicating antigonadotropic properties. Increase in uterine weight and well defined vaginal keratinization was seen in Danazol treated ovariectomized animals. The results were similar to that of oestradiol dipropionate confirming the oestrogenic activity of Danazol.
D000818:Animals; D002369:Castration; D003613:Danazol / Q000494:pharmacology*; D005260:Female; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects / Q000502:physiology*; D011245:Pregnadienes / Q000494:pharmacology*; D051381:Rats; D014599:Uterus / Q000502:physiology*; D014621:Vagina / Q000187:drug effects / Q000502:physiology*
D011245:Pregnadienes; D003613:Danazol