Lack of induction of dominant lethal mutations in male mice by nalidixic acid.
Nalidixic acid (NA) in single or in 5 consecutive daily doses of 100 or 1000 mg/kg produced no dominant lethal mutational effects in male ddY strain mice during an 8-week mating schedule. Ethylmethanesulfonate (EMS), used as a positive control, produced dominant lethal mutations in the first and second weeks.
D000818:Animals; D005020:Ethyl Methanesulfonate / Q000633:toxicity; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D009268:Nalidixic Acid / Q000633:toxicity*
D009153:Mutagens; D009268:Nalidixic Acid; D005020:Ethyl Methanesulfonate