Airway function in sarcoidosis: effect of short-term steroid therapy.
13 previously untreated patients suffering from early pulmonary sarcoidosis (stages II and III) were studied radiologically and physiologically after 4 months of corticosteroid treatment. The results of airway function studies before and after corticosteroid treatment were compatible with small airway disease that did not improve after treatment. Before steroids, the main abnormalities were decreased diffusion and compliance, increased alveolar-arterial oxygen tension gradients, and the presence of frequency-dependent compliance. After steroids, significant improvement was found in diffusion and alveolar-arterial oxygen tension gradients, but compliance as well as frequency-dependent compliance did not improve.
D000328:Adult; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D012119:Respiration; D012129:Respiratory Function Tests; D012507:Sarcoidosis / Q000188:drug therapy / Q000503:physiopathology*; D012907:Smoking; D013997:Time Factors
D005938:Glucocorticoids; D011241:Prednisone