[Changes in the indices affecting the phospholipid structure of high density lipoprotein subfractions in ischemic heart disease].
As the alpha-cholesterol concentration decreased in blood plasma of healthy men, relative content of oleic and linoleic acids was also decreased in phospholipids of HDL2 subfraction without any alterations in HDL3 fraction. In the patients with ischemic heart disease content of linoleic acid was lower in the phospholipids and the ratio free cholesterol (HDL2 phospholipids was higher as compared with the group of healthy persons exhibiting the similar low content of cholesterol in HDL. The molar ratio free cholesterol) phospholipids was higher in the HDL3 fraction of the patients as compared with healthy persons, however composition of fatty acids was unaltered in the phospholipids Activity of lecithine cholesterol acyltransferase was lower in the patients as compared with healthy persons exhibiting the same content of cholesterol in HDL. Administration of heparin into the patients was responsible for an increase in the level of unsaturated phospholipids in HDL2 fraction (while they decreased in VLDL/as well as for a decrease in the ratio cholesterol/phospholipids. The data obtained suggest that alterations in the physico-chemical properties of the fraction studied might affect the antiatherogenic characteristics of HDL.
D003327:Coronary Disease / Q000097:blood*; D005227:Fatty Acids / Q000097:blood; D005609:Free Radicals; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D007009:Hypolipoproteinemias / Q000097:blood; D008066:Lipolysis / Q000187:drug effects; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood; D010743:Phospholipids / Q000097:blood*
D005227:Fatty Acids; D005609:Free Radicals; D008075:Lipoproteins, HDL; D010743:Phospholipids; D006493:Heparin; D007862:Phosphatidylcholine-Sterol O-Acyltransferase
Izmeneiia pokazateleĭ, vliiaiushchikh na strukturu fosfolipidov podfraktsiĭ lipoproteidov vysokoĭ plotnosti, u bol'nykh ishemicheskoŏ bolezn'iun serdtsa.