Formation of tissue-bound N'-nitrosonornicotine metabolites by the target tissues of Sprague-Dawley and Fisher rats.
The distribution and metabolism of N' -[14C] nitrosonornicotine ([14C]NNU) was studied in Sprague-Dawley and Fisher rats, in which NNN induces tumours preferentially of the nasal cavity and the oesophagus. After i.v. injections of [14C] NNN, a localization of tissue-bound metabolites weas found in the mucosa of the nasal cavity and oesophagus. These tissues were also found to have a capacity to form tissue-bound metabolites from NNN in vitro. These data suggest that in situ metabolic activation of NNN plays an important role in the pathogenesis of the NNN-induced tumours of the nasal cavity and the oesophagus in the rat.
D000818:Animals; D001345:Autoradiography; D001711:Biotransformation; D002273:Carcinogens / Q000378:metabolism*; D009538:Nicotine / Q000031:analogs & derivatives* / Q000378:metabolism; D009602:Nitrosamines / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D013045:Species Specificity
D002273:Carcinogens; D009602:Nitrosamines; D009538:Nicotine; C008655:N'-nitrosonornicotine