title: Conformational changes and drug action.
abstract: Conformational changes induced or selected by drugs in receptors may be coupled to second sites on receptor molecules giving negative or positive cooperative binding. The structure-activity relationships may be changed depending on the predominant conformation. Some conformational changes can be identified by nuclear magnetic resonance spectroscopy. Conformational coupling between subunits is complex and provides a mechanism for modulation of receptor affinity.
mesh_terms: D000818:Animals; D001665:Binding Sites; D006639:Histidine / Q000032:analysis; D006801:Humans; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D009249:NADP; D011485:Protein Binding; D011487:Protein Conformation; D011955:Receptors, Drug / Q000187:drug effects / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism
chemical_list: D011955:Receptors, Drug; D006639:Histidine; D009249:NADP; D013762:Tetrahydrofolate Dehydrogenase