title: Sulfadimidine acetylation in Norwegians. Comparison of sulfadimidine metabolism in Lapps, North Norwegians and South Norwegians.
abstract: The acetylation of sulfadimidine was studied in 152 healthy volunteers (29 Lapps, 73 Norwegians and 50 South Norwegians) by means of fraction acetylated sulfadimidine and drug half-life. The distribution of rapid acetylators was different among Lapps (72%) and South Norwegians (44%) (p less than 0.01). The North Norwegians resembled the South Norwegians, but some regional approach to the Lappish pattern was found. Great interindividual differences in the half-lives were demonstrated. The mean half-life (+/- S.E.M.) was 384 +/- 17 min in slow acetylators and 148 +/- 8 min in rapid acetylators. Among participants with half-lives of sulfadimidine less than 420 min and intraindividual correlation with fraction acetylated sulfadimidine was found. The distribution of fraction acetylated sulfadimidine was bimodal while the distribution of half-lives was suggested to be trimodal.
mesh_terms: D000017:ABO Blood-Group System; D000123:Acetyltransferases / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D005006:Ethnicity; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D009664:Norway; D010641:Phenotype
chemical_list: D000017:ABO Blood-Group System; D000123:Acetyltransferases