Study of recombinants derived from autochthonous influenza virus type A strains.
Simultaneous inoculation of chick embryos with a standard laboratory influenza virus--A/PR8/34 (H0N1)--and with an autochthonous epidemic strain--belonging to the antigenic subtype A(H1N1) of A(H3N2), respectively--resulted in the isolation of two genetic recombinants, designated R1IVN (H1N1) and R2IVN (H3N2). Each recombinant was antigenically identical to its wild-type parent and exhibited a hemagglutinating titer in chick embryos about 4-fold greater than that of the autochthonous parental strain.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002642:Chick Embryo; D006389:Hemagglutinins, Viral / Q000032:analysis; D009980:Influenza A virus / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity; D011995:Recombination, Genetic; D012703:Serotyping
D000956:Antigens, Viral; D006389:Hemagglutinins, Viral