title: Human sperm chromatin has a nucleosomal structure.
abstract: Digestion of human sperm chromatin with micrococcal nuclease reveals an 160 base pair (b.p.) DNA fragment that is further degraded to a series of DNA fragments remarkably similar to the micrococcal nuclease digestion products of eukaryote somatic cellular chromatin. DNase I digestion of human sperm chromatin also yields an identical pattern of DNA fragments to that observed upon DNase I digestion of somatic chromatin. These data, together with earlier electron microscopic observations, suggest a nucleosomal structure for human sperm chromatin.
mesh_terms: D002843:Chromatin / Q000032:analysis* / Q000378:metabolism; D004247:DNA / Q000032:analysis; D003851:Deoxyribonucleases / Q000494:pharmacology; D006801:Humans; D008297:Male; D009707:Nucleosomes / Q000032:analysis*; D013094:Spermatozoa / Q000032:analysis*
chemical_list: D002843:Chromatin; D009707:Nucleosomes; D004247:DNA; D003851:Deoxyribonucleases