Influence of high fat diet on GI absorption of griseofulvin tablets in man.
A controlled crossover study was carried out on five volunteers to substantiate reported effects of fat intake on the bioavailability of griseofulvin. The urinary excretion of 6-demethylgriseofulvin was monitored for 24 h following the administration of 125-mg griseofulvin tablets in the fasting state and after a fatty diet. Statistical analysis of excretion data indicated a significant increase in both rate and extent of absorption of griseofulvin as a result of fat intake. Excretion rate profiles obtained permitted insight into mechanisms possibly involved in the observed drug-diet interaction.
D000328:Adult; D004041:Dietary Fats / Q000494:pharmacology*; D006118:Griseofulvin / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D006801:Humans; D007408:Intestinal Absorption; D008875:Middle Aged; D013607:Tablets; D013997:Time Factors
D004041:Dietary Fats; D013607:Tablets; D006118:Griseofulvin