Effect of selenium on azoxymethane-induced intestinal cancer in rats fed high fat diet.
The effects of selenium supplementation on azoxymethane-induced intestinal cancer were studied in male Sprague- Dawley rats given 8 weekly injections of azoxymethane (8 mg/kg body wt), and fed a 30% beef fat diet. Selenium-supplemented groups received 8 ppm H2SeO3 in drinking water. Blood selenium levels of supplemented rats increased rapidly the first 9 weeks of the experiment, followed by a plateau significantly higher than that for non-selenium controls. There was a significantly increase in liver and intestinal selenium levels in supplemented groups. The average number of intestinal tumors was 6.5 in the control group, and 3.1 in the selenium-supplemented group. There was a significant reduction in tumor incidence in the proximal half of the colon of selenium-treated rats. There was also increased concentration of tissue selenium in the proximal half of the colon of these rats.
D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D001397:Azoxymethane / Q000633:toxicity*; D004041:Dietary Fats / Q000009:adverse effects*; D007414:Intestinal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008099:Liver / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium / Q000378:metabolism / Q000633:toxicity*
D001391:Azo Compounds; D004041:Dietary Fats; D012643:Selenium; D001397:Azoxymethane