Ultrastructural lesion in fetal hemopoietic cells following ethanol administration to pregnant mice.
Ethanol administration by gavage to pregnant CF1 mice induced myelin-like laminar figures in mitochondria and Golgi complexes of proerythroblasts and erythroblasts in hemopoietically active fetal livers. The laminar figures were observed to be extruded by exotrophy in rare instances. The fetal hemopoietic tissues of sucrose-fed, sham, and untreated pregnant mice rarely displayed laminar figures in immature erythroid cells.
D000818:Animals; D004900:Erythroblasts / Q000648:ultrastructure; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006413:Hematopoietic System / Q000187:drug effects* / Q000648:ultrastructure; D006861:Hydrogen Peroxide / Q000633:toxicity; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008928:Mitochondria / Q000187:drug effects; D011247:Pregnancy
D000431:Ethanol; D006861:Hydrogen Peroxide