[Effect of serotonin on chromatin protein methylation in radiation injury].
The paper deals with the influence of the X-irradiation and serotonin, as a radioprotector, on the chromatin protein methylation. It is shown that the X-irradiation and serotonin cause changes in the intensity of chromatin protein methylation in vivo, that may be explained by their effect on the activity of the corresponding methylases. Possible relationships between the changes in methylation of chromatin proteins and the general response of the organism to the irradiation, including administration of the radioprotector is under discussion.
D000818:Animals; D002843:Chromatin / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D008297:Male; D008745:Methylation; D009698:Nucleoproteins / Q000378:metabolism*; D011496:Protein Methyltransferases / Q000378:metabolism*; D011837:Radiation-Protective Agents; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*
D002843:Chromatin; D009698:Nucleoproteins; D011837:Radiation-Protective Agents; D012701:Serotonin; D011496:Protein Methyltransferases
Vliianie serotonina na metilirovanie belkov khromatina pri luchevom porazhenii.