Melatonin: identification of sites of antigonadal action in mouse brain.
Long-term implants releasing a small quantity of melatonin (45 nanograms per day) were used to determine the brain sites of the hormone's antigonadal action in a photoperiodic species, the white-footed mouse (Peromyscus leucopus). Implants in the medial preoptic and supra- and retrochiasmatic areas elicited completed gonadal regression after 7 weeks. Implants in other brain regions had little effect on the animals' reproductive state.
D000818:Animals; D005260:Female; D005836:Genitalia, Female / Q000187:drug effects / Q000473:pathology*; D007031:Hypothalamus / Q000187:drug effects*; D008027:Light; D008550:Melatonin / Q000494:pharmacology*; D051379:Mice; D010507:Periodicity; D011301:Preoptic Area / Q000187:drug effects; D013495:Supraoptic Nucleus / Q000187:drug effects
D008550:Melatonin