title: The effect of labetalol and propranolol on the pressor response to sexual arousal in women.
abstract: 1 The effect of a single oral dose of labetalol (100 mg), propranolol (80 mg) and placebo on the pressor response to sexual autostimulation has been studied in six female volunteers. 2 Labetalol but not propranolol significantly reduced the increase in blood pressure that occurred at orgasm. 3 The subjective features of the sexual response were assessed by each subject using visual analogue scales. 4 Subjects reported a significant reduction in vaginal lubrication with labetalol compared to both placebo and propranolol. 5 No other effects were noted.
mesh_terms: D000328:Adult; D001143:Arousal / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects*; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007741:Labetalol / Q000494:pharmacology*; D009948:Orgasm / Q000502:physiology*; D011433:Propranolol / Q000494:pharmacology*
chemical_list: D004983:Ethanolamines; D011433:Propranolol; D007741:Labetalol