[Experimental electrocardiographic research. Study in the rat of the cardiovascular effects of labetalol].
Electrocardiographic changes induced by Labetalol, a drug blocking alpha- and beta-adrenergic receptors, have been studied in 10 anesthetized rats. Authors observed that Labetalol has: 1) slightly negative chronotropic action; 2)slightly negative dromotropic action on both atrio-ventricular and intraventricular conduction; 3) effective antiarrhythmic and alpha-blocking action and, inconstantly, 4) the so-called "intrinsic sympathicomimetic action" (I.S.A.), typical of several beta-blocking drugs.
D000818:Animals; D003864:Depression, Chemical; D004562:Electrocardiography; D004983:Ethanolamines / Q000494:pharmacology*; D006329:Heart Conduction System / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D007741:Labetalol / Q000494:pharmacology*; D009431:Neural Conduction / Q000187:drug effects; D051381:Rats
D004983:Ethanolamines; D007741:Labetalol
Ricerche di elettrocardiografia sperimentale. Studio nel ratto degli effetti cardiovascolari del labetalolo.