The disposition and metabolism of 3,4',5-tribromosalicylanilide and 4'5-dibromosalicylanilide in the rat.
1. The metabolism of two pesticides, 3,4',5-tribromosalicylanilide (TBS) and 4',5-dibromosalicylanilide (DBS) has been studied after oral administration to rats. 2. Approximately 65% of the dose of TBS is absorbed, and then excreted as glucuronide and sulphate conjugates of two hydroxylated metabolites. One of these has been identified as 4'-hydroxy-3,5-dibromosalicylanilide, while evidence suggests that the other metabolite is 5-hydroxy-3,4'-dibromosalicylanilide. 3. In contrast, only 11% of the dose of DBS is absorbed; it is then excreted mainly as glucuronide and sulphate conjugates of the parent molecule.
D000818:Animals; D001646:Bile / Q000378:metabolism; D005243:Feces / Q000032:analysis; D005260:Female; D007408:Intestinal Absorption; D008297:Male; D010575:Pesticides / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012457:Salicylamides / Q000378:metabolism*; D012458:Salicylanilides / Q000378:metabolism*; D014018:Tissue Distribution
D010575:Pesticides; D012457:Salicylamides; D012458:Salicylanilides; C004361:tribromsalan; C007323:dibromsalan