Separate and combined effects of timolol maleate and acetazolamide in open-angle glaucoma.
We compared the intraocular pressure-decreasing effect of timolol maleate alone, acetazolamide alone, and combined timolol and acetazolamide therapy in nine patients with bilateral chronic open-angle glaucoma. Timolol decreased intraocular pressure at least as effectively as acetazolamide. The two medications together were more effective than either medication alone, but they did not have a fully additive effect. Episcleral venous pressures and outflow facilities did not vary significantly with any of the three treatment regimens.
D000086:Acetazolamide / Q000494:pharmacology / Q000627:therapeutic use*; D000368:Aged; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000627:therapeutic use*; D013999:Timolol / Q000494:pharmacology / Q000627:therapeutic use*
D011412:Propanolamines; D013999:Timolol; D000086:Acetazolamide