Differential neurobehavioral effects of neurotensin and structural analogues.
Neurobehavioral effects of neurotensin and structural analogues in which tyrosine in position 11 was replaced by either its d-isomer [D-Tyr11]-NT, phenylalanine [Phe11]-NT or D-phenylalanine [D-Phe11]-NT were studied. Results demonstrate that whereas neurotensin and [Phe11]-NT significantly decreased motor activity in rats, [D-Tyr11]-NT and [D-Phe11]-NT produced a marked and significant increase in activity. Such dichotomous action between analogues was not found for the hypothermic and muscular relaxation effects of neurotensin.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007536:Isomerism; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects; D009496:Neurotensin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D009496:Neurotensin