[Effect of glucocorticoids on the fractional composition and derivatives of hemoglobin in rats].
Experiments on rats have shown that administration of hydrocortisone in a dose of 10 mg/kg, prednisolone in a dose of 2.5 mg/kg, dexamethasone (0.3 mg/kg) and triamcinolone (2 mg/kg) over 14 days result in the decreased number of fractions, in the redistribution of the drug content by fractions, and in the rise of the methemoglobin content. The carboxyhemoglobin content changes but little under the effect of hydrocortisone and prednisolone but significantly increases after dexamethasone and triamcinolone administration. In vitro experiments have shown that hormone preparations are capable of increasing the methemoglobin content at the expense of immediate effect on red cells.
D000818:Animals; D002263:Carboxyhemoglobin / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology*; D006454:Hemoglobins / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D008706:Methemoglobin / Q000378:metabolism; D011239:Prednisolone / Q000494:pharmacology*; D051381:Rats; D014221:Triamcinolone / Q000494:pharmacology*
D006454:Hemoglobins; D014221:Triamcinolone; D003907:Dexamethasone; D008706:Methemoglobin; D002263:Carboxyhemoglobin; D011239:Prednisolone; D006854:Hydrocortisone
Vliianie gliukokortikoidov na fraktsionnyĭ sostav i proizvodnye gemoglobina u krys.