title: Effector cell sensitivity to sugar moieties. I. Inhibition of human natural killer cell activity by monosaccharides.
abstract: Human natural killer (NK) cells recognize multiple target antigens. The ligands (antigens) involved in the effector-target cell interaction have not been extensively identified. In the present study, assays of NK activity in the presence of a panel of monosaccharides demonstrated inhibition of cytolysis in a dose-response fashion. We propose that NK cell activity involves the recognition of carbohydrate structures on target cells via receptors on the effector cell surface.
mesh_terms: D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects*; D000941:Antigens / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D009005:Monosaccharides / Q000276:immunology / Q000494:pharmacology*; D011946:Receptors, Antigen / Q000276:immunology
chemical_list: D000941:Antigens; D009005:Monosaccharides; D011946:Receptors, Antigen