[Repair of DNA-protein cross-links induced by antineoplastic alkylating agents].
The bifunctional and antitumor alkylating agents embichin and its aromatic derivatives sarcolysin and chlorfenacyl remarkably differ in DNA-protein cross-links induction in Chinese hamster cell cultures in vitro. The differences involve the concentration necessary for cross-linkage, the time of cross-links emergence, and their reparation. Since all three compounds have the same alkylating group, it is obvious that the differences seen in the cross-linkage arise from the structure of aromatic groupings introduced into the molecule.
D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000378:metabolism*; D004260:DNA Repair; D005347:Fibroblasts; D008466:Mechlorethamine / Q000494:pharmacology; D008558:Melphalan / Q000494:pharmacology; D009698:Nucleoproteins / Q000378:metabolism*
D000477:Alkylating Agents; D000970:Antineoplastic Agents; D009698:Nucleoproteins; D008466:Mechlorethamine; D004247:DNA; D008558:Melphalan
Izuchenie reparatsii sshivok DNK--belok, indutsirovannykh protivoopukholevymi alkiliruiushchimi agentami.