title: Automated physiological profile assessment of effects of altered cardiovascular dynamics on brain blood flow.
abstract: Brain blood flow may be compromised as severely by altered cardiovascular dynamics as by atherosclerotic flow-limiting lesions in carotid arteries. The Automated Physiologic Profile can distinguish between those clinically important mechanisms. The Automated Physiologic Profile is a concept and method and apparatus. Physiologic performance of the heart, vascular tone in systemic and pulmonary vessels, and oxygen consumption are derived and printed on a standard report form. This easy to use form identifies mechanisms and illustrates severity of patho-physiologic aberrations contributing to ischemia-inducing processes. Serial portrayal depicts effectiveness of therapeutic interventions. This report included examples of APP in patients with ventricular rhythm disturbance, sick sinus syndrome, hypovolemic low cardiac out-put, and carotid artery stenosis as contributing factors in clinical cerebrovascular insufficiency. All were accompanied by excessive systemic arteriolar resistance, implying reduced brain blood flow. Serial APPs correlated with clinical events in the case histories.
mesh_terms: D000368:Aged; D001157:Arterial Occlusive Diseases / Q000503:physiopathology; D001921:Brain / Q000098:blood supply*; D002302:Cardiac Output; D002319:Cardiovascular System / Q000503:physiopathology*; D002340:Carotid Artery Diseases / Q000503:physiopathology; D006331:Heart Diseases / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods*; D012039:Regional Blood Flow