Effects of pneumolysin on human polymorphonuclear leukocytes and platelets.
Pneumolysin was bound by human polymorphonuclear leukocytes in a reaction which occurred very rapidly at 0 degrees C. Low concentrations of pneumolysin were found to stimulate leukocyte migration and lysosomal enzyme secretion. At increasing lysin levels, inhibition of spontaneous migration and chemotaxis, cell death, and lysis were observed. Pneumolysin was also found to lyse platelets and to activate serum to become chemotactic.
D001426:Bacterial Proteins; D001792:Blood Platelets / Q000502:physiology*; D002448:Cell Adhesion; D002449:Cell Aggregation; D002470:Cell Survival; D002634:Chemotaxis, Leukocyte; D006801:Humans; D009113:Muramidase / Q000378:metabolism; D009504:Neutrophils / Q000502:physiology*; D013301:Streptolysins / Q000378:metabolism / Q000494:pharmacology*
D001426:Bacterial Proteins; D013301:Streptolysins; C032290:plY protein, Streptococcus pneumoniae; D009113:Muramidase