Amyloidosis and systemic lupus erythematosus.
A 59 year old man with systemic lupus erythematosus developed proteinuria and renal insufficiency. Renal biopsy revealed both crescentic glomerulonephritis and amyloid in glomeruli and blood vessels. The amyloid was characterized as secondary because of its sensitivity to potassium permanganate pretreatment of Congo red stained sections. Amyloidosis is very uncommon in systemic lupus erythematosus but may be a cause of steroid unresponsive proteinuria and renal insufficiency.
D000686:Amyloidosis / Q000150:complications / Q000473:pathology*; D005921:Glomerulonephritis / Q000150:complications / Q000473:pathology*; D006801:Humans; D007678:Kidney Glomerulus / Q000648:ultrastructure; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged