[Blastomogenic action of low concentrations of nitrosodimethylamine, dimethylamine and nitrogen dioxide].
The round-the clock inhalation of the mixture of nitrosodimethylamine (NDMA), dimethylamine (DMA) and nitrogen dioxide, with NDMA concentrations varying within 0.66-0.0026 mg/m3, was followed by development of tumors in the kidney, liver, lungs and at other sites in albino nonbred rats, after a year of exposure. Application of DMA and nitrogen dioxide modified the carcinogenic effect of NDMA. In male rats, the blastogenic effect of the mixture was higher, as compared with that of inhalation of NDMA alone. NDMA inhalation resulted in a lower tumor yield in female rats.
D000818:Animals; D003043:Cocarcinogenesis; D004123:Dimethylamines / Q000008:administration & dosage*; D004128:Dimethylnitrosamine / Q000008:administration & dosage*; D004357:Drug Synergism; D004781:Environmental Exposure; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009585:Nitrogen Dioxide / Q000008:administration & dosage*; D051381:Rats; D013997:Time Factors
D004123:Dimethylamines; D004128:Dimethylnitrosamine; D009585:Nitrogen Dioxide
Izuchenie blastomogennogo deĭstviia malykh kontsentratsiĭ nitrozodimetilamina, dimetilamina i dvuokisi azota.