Effect of hydrogen sulfide on bacterial inactivation in the rat lung.
This study evaluated the effect of a low concentration of hydrogen sulfide on the rat antibacterial defense system. Rats exposed to 45 ppm hydrogen sulfide (threshold limit value for hydrogen sulfide = 10 ppm) for 4 or 6 hr exhibited a significant (P less .01) reduction in the inactivation of viable staphylococci deposited in the lungs during a bacterial aerosol challenge. Pre-exposure of rats to 46 ppm hydrogen sulfide for 2 hr, however, did not alter intrapulmonary staphylococcal inactivation. We hypothesize that impairment of the alveolar macrophage is the basis of these findings.
D000336:Aerosols; D000818:Animals; D002923:Cilia / Q000187:drug effects / Q000502:physiology; D006862:Hydrogen Sulfide / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects / Q000382:microbiology* / Q000502:physiology; D008264:Macrophages / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010587:Phagocytosis; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000382:microbiology / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013210:Staphylococcus / Q000254:growth & development*
D000336:Aerosols; D006862:Hydrogen Sulfide