In vitro influence of some mammalian pituitary and placental hormones on androgen production by the lizard testis.
Effect of mammalian pituitary and placental hormones has been studied on in vitro androgen production by the testis of the spiny-tailed lizard, Uromastix hardwicki. Aliquots of pooled testicular tissue from adult lizards were incubated individually with 1 microgram each, of oFSH, oLH, oTSH and 1 IU each of hCG, PMSG, and ACTH. Androgen was measured by testosterone radioimmunoassay in both the tissue and the incubation medium. Severalfold increase in androgen production was observed in the testicular tissue incubated with FSH, LH, TSH nd PMSG. Maximum stimulation was obtained with FSH. hCG also caused a measurable increase in androgen production but was much less potent than PMSG. Incubation of testicular tissue with ACTH did not result in a significant change in androgen production as compared to the controls. The hormonal specificity for steroidogenesis by the lizard testis has been discussed in the light of these results.
D000728:Androgens / Q000096:biosynthesis*; D000818:Animals; D008116:Lizards; D008297:Male; D010908:Pituitary Hormones, Anterior / Q000494:pharmacology*; D010926:Placental Hormones / Q000494:pharmacology*; D013737:Testis / Q000187:drug effects / Q000378:metabolism*
D000728:Androgens; D010908:Pituitary Hormones, Anterior; D010926:Placental Hormones