title: Effects of intracerebroventricular administration of aliphatic diamines on ingestive behavior in the rat.
abstract: We examined the pharmacological effects of intracerebroventricularly administered aliphatic diamines on ingestive behavior in male rats adapted to a 4 hr per day feeding and drinking schedule. 1,2-Ethanediamine (ETD), 1,3-propanediamine (PRD), 1,4-butanediamine (putrescine, PUT), 1,5-pentanediamine (cadaverine, CAD) and 1,6-hexanediamine (HED) suppressed feeding and drinking behavior in a dose-dependent manner, but not unless a relatively high dose (over 80 micrograms) was given. The approximate anorectic potency was HED greater than CAD divided by PUT greater than ETD greater than PRD. A sedation was also produced in fairly good parallel to these alterations in feeding and drinking behavior. Thus, there appears to be a relationship between the length of the carbon chain and the potency of the pharmacological action, and these inhibitory effects on feeding and drinking behavior are probably not due to a specific action on the regulatory system for ingestive behavior, but rather to a nonspecific action.
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology; D002103:Cadaverine / Q000494:pharmacology; D003959:Diamines / Q000008:administration & dosage / Q000494:pharmacology*; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D005029:Ethylenediamines / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D011700:Putrescine / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001067:Appetite Depressants; D003959:Diamines; D005029:Ethylenediamines; C031234:ethylenediamine; C009475:trimethylenediamine; D002103:Cadaverine; D011700:Putrescine; C007297:1,6-diaminohexane