[Prevention of hypoxic heart damage by means of an antioxidant of the hydroxypyridine class].
A study was made of the effect of preadministering a water-soluble antioxidant (HP-6) belonging to th hydroxypyridine series on the development of hypoxic contracture and stressor heart injury. It was found that under hypoxia, the control animals and those exposed to emotional and pain stress develop characteristic heart contracture manifested by a rise in the diastolic pressure up to 40-47 mm Hg, as well as an abrupt increase in creatine phosphokinase egress from injured myocardial cells into perfusate. Administration of HP-6 to the animals for 3 days before stress and heart removal prevented to an appreciable degree the heart contracture and creatine phosphokinase egress. Also it made the recovery of contractility more rapid and complete during reoxygenation. It should be noted that in the animals which received HP-6 before stress, the contractility got recovered to a far greater extent than that in the controls. The evidence obtained suggests an important role played by activation of lipid peroxidation in the pathogenesis of hypoxic contracture and reoxygenation-induced heart injury.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D009202:Cardiomyopathies / Q000517:prevention & control*; D003402:Creatine Kinase / Q000378:metabolism; D000860:Hypoxia / Q000188:drug therapy*; D008297:Male; D009206:Myocardium / Q000201:enzymology; D010477:Perfusion; D010847:Picolines; D011725:Pyridines / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000188:drug therapy*
D000975:Antioxidants; D010847:Picolines; D011725:Pyridines; D003402:Creatine Kinase; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Preduprezhdenie gipoksicheskogo povrezhdeniia serdtsa s pomoshch'iu antioksidanta iz klassa oksipiridinov.