Cycloheximide treatment modifies the pattern of "metastasis" following intravenous injection of Ehrlich ascites tumour cells.
Cyclohexamide treatment of recipient mice at various times in relation to an intravenous injection of Ehrlich ascites tumor cells alters the pattern of consequent "metastatic" disease as compared with the pattern in untreated, tumour-injected animals. Analysis of the results suggests the existence of a cycloheximide-sensitive host mechanism for eliminating arrested tumour cells. This mechanism could play an important role in determining the ultimate localisation pattern of neoplastic disease following an intravenous injection of Ehrlich tumour cells.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology*; D003513:Cycloheximide / Q000494:pharmacology*; D005260:Female; D007275:Injections, Intravenous; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation
D003513:Cycloheximide