[Physostigmine and reversal of anticholinergic effects of neurolept-anaesthesia (author's transl)].
After 486 gynaecological procedures performed under neuroleptanaesthesia 32 patients remained irresponsive despite naloxone reversal of possible fentanyl overdose and exclusion by peripheral nerve stimulation of prolonged neuromuscular blockade. By random selection 18 of these (group A) received physostigmine 2 mg, 14 patients (group B) served as controls. Groups were comparable concerning age, technique and duration of anaesthesia, total doses of anaesthetics and muscle relaxants. Patients in group A were fully responsive within 9 +/- 4,6 min. after physostigmine, patients without this drug (group B) however within 49 +/- 19 min. This difference was highly significant (P less than 0,001).
D001285:Atropine / Q000009:adverse effects; D003243:Consciousness / Q000187:drug effects; D003864:Depression, Chemical; D004329:Droperidol / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D005283:Fentanyl / Q000009:adverse effects; D005831:Genital Diseases, Female / Q000601:surgery; D006801:Humans; D009270:Naloxone / Q000627:therapeutic use; D009458:Neuroleptanalgesia / Q000379:methods*; D010276:Parasympatholytics; D010830:Physostigmine / Q000627:therapeutic use*
D010276:Parasympatholytics; D009270:Naloxone; D001285:Atropine; D010830:Physostigmine; D004329:Droperidol; D005283:Fentanyl
Physostigmin als Antagonist der anticholinergen Depression nach Neuroleptanästhesie.