[Sharp increase in refractory period induced by oxidation suppression in Fitz Hugh-Nagumo model. New mechanism of antiarrhythmic drug action].
A change in fast inward and slow outward currents and their time constants was simulated in Fitz Hugh-Nagumo model. A decrease in fast inward current was shown to increase the refractory period. The same result was observed when the slow current was increased or its time constant was decreased. These results were used to explain the antiarrhythmic drug action. The antiarrhythmic effect of drugs blocking fast inward current should be stronger in the depressed myocardial tissue than in the normal one.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D006321:Heart / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects*; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D010084:Oxidation-Reduction
D000889:Anti-Arrhythmia Agents
Rezkiĭ rost refrakternosti pri podavlenii vozbudimosti v modeli Fitz Hugh-Nagumo. Novyĭ mekhanizm deĭstviia antiaritmikov.