[Genetic differences in the anticonvulsant effect and rate of metabolism of phenazepam].
The metabolic rate of 14C-phenazepam (14 mg/kg) in male C57BL/6 and BALB/c mice and F1 hybrids (BALB/c X C57BL/6) and the anticonvulsant effect of the tranquilizer in hybrid mice were studied. It was demonstrated that oxidation of the phenazepam molecule in the third position in BALB/c mice and in F1 hybrids proceeded at a higher rate than in C57BL/6 mice. The sensitivity to the anticonvulsant effect of phenazepam in C57BL/6 animals was greater than in BALB/c mice and F1 hybrids.
D000818:Animals; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D006824:Hybridization, Genetic; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008967:Molecular Biology
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam
Izuchenie geneticheskikh razlichii v protivosudorozhnom éffekte i skorosti metabolizma fenazepama.