title: Non-suppressible insulin-like activity during pregnancy in women with diabetes mellitus.
abstract: Serum levels of the growth factor non-suppressible insulin-like activity (NSILA-S) have been measured in eleven pregnant women with diabetes mellitus during pregnancy and immediately (2 days) after birth. A significant increase in mean levels was observed with increasing gestation, reaching a peak at the time of delivery and subsequently returning to non-pregnant levels within 2 days. The NSILA-S levels in diabetic pregnancies were not different from those in non-diabetic pregnancies and there were no significant correlations between NSILA-S and birth weight, maternal diabetic control, age or duration of diabetes or the treatment required. The physiological role of high NSILA-S levels during pregnancy still requires elucidation.
mesh_terms: D000328:Adult; D001724:Birth Weight; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008875:Middle Aged; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood*; D013002:Somatomedins / Q000097:blood*
chemical_list: D013002:Somatomedins