[Comparative characteristics of the self-stimulation response in rabbits following administration of angiotensin II into the cerebral ventricles and application to the conjunctiva].
Experiments on rabbits have shown that intraventricular administration of angiotensin II induces the dose-dependent suppression of the self-stimulation reaction after varying intervals. The same suppression of the self-stimulation in rabbits but after a greater interval is produced by the application of angiotensin aqueous solution to the eye conjunctiva. In both cases the amount of drinking reactions in the animals significantly rises after the oligopeptide administration as compared with controls. Examination of the time course of arterial pressure, respiration and ECG has shown that only intravenous injection of angiotensin II in doses of 500 ng provokes a temporary increase in arterial pressure, marked bradycardia and changes in respiration, whereas other routes of administration produce no changes in the characteristics studied.
D000287:Administration, Topical; D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003228:Conjunctiva; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D011817:Rabbits; D012653:Self Stimulation / Q000187:drug effects*
D000804:Angiotensin II
Sravnitel'naia kharakteristika reaktsii samorazdrazheniia u krolikov pri vvedenii angiotenzina II v zheludochki mozga i pri applikatsii na kon"iunktivu glaza.