Reactions of cyanomethylbenzimidazoles. Part IV. Derivatives of 2-[alpha-cyano-beta-aryl-(dialkyl)-vinyl]-benzimidazole and N-arylthioamides of benzimidazolyl-2-alpha-cyanoacetic acid and their tuberculostatic activity.
Several derivatives of N-arylthioamide of benzimidazolyl-2-alpha-cyanoacetic acid and 2-(alpha-cyano-beta-chlorophenyl)-benzimidazole and its 4(7)- and 5(6)-methyl derivatives have been obtained. Tuberculostatic activity of these compounds was determined on the Mycobacterium tuberculosis H37Rv strain. LD50 values were determined for derivatives of 2-(alpha-cyano-beta-arylvinyl)-benzimidazoles. The compounds show moderate toxicity.
D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology* / Q000633:toxicity; D001562:Benzimidazoles / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice
D000995:Antitubercular Agents; D001562:Benzimidazoles