Benzodiazepines reduce gastric ulcers induced in rats by stress.
1 The sedative and antiulcer effects of chlordiazepoxide (5 to 50 mg/kg) and lorazepam (0.25 to 2.5 mg/kg) were investigated in the rat. 2 Sedation was measured by recording locomotor activity in a holeboard. Ulceration of the glandular stomach was induced by a 2 h period of restrain at 4 degrees C. 3 Acutely, both drugs produced significant sedation at all doses; high doses only (chlordiazepoxide 10 and 50 mg/kg; lorazepam 2.5 mg/kg) produced a significant reduction in ulcer formation. 4 With chronic treatment, after 5 and 10 days administration of chlordiazepoxide (50 mg/kg), tolerance to sedation was observed without a similar change in antiulcer action. 5 Cimetidine (20 mg/kg) and atropine (0.2 mg/kg) decreased ulcer formation without causing sedation. 6 The antisecretory profile of chlordiazepoxide (2 x 10(-4) M), in the rat isolated gastric mucosa, resembled that of atropine (10(-7) M) rather than cimetidine (10(-5) M). 7 These observations suggest that the antiulcer effect of benzodiazepines probably results from a combination of sedative, anxiolytic and antisecretory actions.
D000818:Animals; D001285:Atropine; D001569:Benzodiazepines / Q000627:therapeutic use*; D002707:Chlordiazepoxide / Q000627:therapeutic use; D002927:Cimetidine / Q000627:therapeutic use; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D066298:In Vitro Techniques; D008140:Lorazepam / Q000627:therapeutic use; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications*
D006993:Hypnotics and Sedatives; D001569:Benzodiazepines; D002707:Chlordiazepoxide; D001285:Atropine; D002927:Cimetidine; D008140:Lorazepam