Alcohol inhibition of rectosigmoid motility in humans.
The effects of acute intravenous alcohol infusion or sham treatment with normal saline on rectosigmoid motility was determined in healthy adult volunteer subjects. A significant reduction of rectosigmoid wave frequency, amplitude, percent activity and motility index occurred in subjects infused with alcohol when compared to their basal period or corresponding periods in the sham-treated group. Chemical intoxication was achieved in all subjects given alcohol and the percent of the basal motility index varied inversely with the blood alcohol level.
D000328:Adult; D012809:Colon, Sigmoid / Q000187:drug effects*; D003967:Diarrhea / Q000139:chemically induced; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D012007:Rectum / Q000187:drug effects*
D000431:Ethanol