Carcinogenic effect of chronic subcutaneous injections of 2,6-dimethylnitrosomorpholine in Sprague-Dawley rats.
Sprague-Dawley rats received subcutaneous injections of 2,6-dimethylnitrosomorpholine (2,6-DMNM) at 3 different dose levels (1/5, 1/10 or 1/20 LD50) once weekly for life. Up to a 100% rate of tumors of the esophagus was detected in animals which received 1/10 and 1/20 LD50. In addition to tumors of this organ, neoplasms developed at different rates in the lungs and in the liver.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D004938:Esophageal Neoplasms / Q000139:chemically induced; D005260:Female; D007279:Injections, Subcutaneous; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009602:Nitrosamines / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; D009602:Nitrosamines; C014130:N-nitroso-2,6-dimethylmorpholine