[Antihypoxic action of orotic acid].
The authors examined the effect of the ortonic acid in comparison with several preparations from various pharmacologic groups on models of complete ischemia, obtained by decapitation and hypobaric hypoxia in mice. The ortonic acid showed strong anti-hypoxic effect in these two models. The results revealed that the strongest effect manifested the ortonic acid, followed by vinponcetine and cinarizine, in mice with hypoxia, induced by decapitation and by the method of hypobaric hypoxia. Hexobarbital-sodium and papaverine showed comparatively weaker effect, but xantional nicotinate - the slightest. A wide spectrum od drugs, known by experimental and clinical data as antihypoxic drugs allowed the authors to accept the models as relative and the conclusion for the effect of the ortonic acid was considered as significant. They assume that vascular and metabolism effect participates in the mechanism of the antihypoxic action of the ortonic acid.
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006591:Hexobarbital / Q000627:therapeutic use; D000860:Hypoxia / Q000188:drug therapy*; D051379:Mice; D008815:Mice, Inbred Strains; D009963:Orotic Acid / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use; D014748:Vinca Alkaloids / Q000627:therapeutic use
D014665:Vasodilator Agents; D014748:Vinca Alkaloids; C013983:vinpocetine; D009963:Orotic Acid; D006591:Hexobarbital
Antikhipoksichnoto deĭstvie na orotova kiselina.