Synthesis of new polyamine derivatives for cancer chemotherapeutic studies.
Selected homologs, analogs, and acylated derivatives of spermine and spermidine, together with several heterocyclic and aromatic compounds containing a novoldiamine side chain, were prepared and evaluated biologically. Several compounds possessed activity against B-16 melanoma and human epidermoid carcinoma of the nasopharynx.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy; D011073:Polyamines / Q000138:chemical synthesis* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D011073:Polyamines