title: [Grumose alteration of the cerebellar dentate nucleus in two cases of progressive supranuclear palsy (author's transl)].
abstract: The purpose of this paper is to illustrate an interesting lesion of the cerebellar dendate nucleus: the grumose alteration which is demonstrated by silver impregnation techniques in two cases of progressive supranuclear palsy. The grumose alteration is nearly exclusively found in the parvocellular part of the dentate nucleus; it is characterized by a clustering of granules and ring-shaped bodies against neuronal perikarya and dentrites; it corresponds very likely to reactive presynaptic endings of Purkinje cells' axons. Similar lesions can be discovered in various neurodegenerative disorders. The morphologic features of the grumose alteration are reviewed.
mesh_terms: D000368:Aged; D002529:Cerebellar Nuclei / Q000473:pathology*; D003704:Dementia / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009127:Muscle Rigidity / Q000473:pathology; D009886:Ophthalmoplegia / Q000473:pathology*; D011689:Purkinje Cells / Q000473:pathology; D013569:Synapses / Q000473:pathology; D013577:Syndrome
vernacular_title: Altération grumeleuse du noyau dentelé du cervelet dans deux cas de paralysie supranucléaire progressive de Steele-Richardson-Olszewski.