[Effect of 2 mercaptopropionylglycine on the cytotoxic activity of lymphocytes from patients with chronic active hepatitis against rabbit hepatocytes isolated and cultured in vitro].
"In vivo" and "in vitro" action of 2 MPG on lymphocytotoxic activity was evaluated in 22 patients with CAH, 14 were HBsAg positive and 8 were negative. The test was performed with and without 2 MPG in the colture medium, and before and after treatment. HBsAg+ patients received 2 MPG treatment, while HBsAg- ones received immunosoppressive therapy and 4 of these were on 2 MPG treatment as well. Cytotoxic Index was reduced non-significantly by addition of 2 MPG in colture medium in both groups. 2 MPG treatment does not modify cytotoxic activity which is reduced by immunosoppressive therapy. These findings suggest a positive effect of 2 MPG on liver-cell metabolism with an increased resistence of the epatocyte to the "in vitro" lymphocytes aggression. Hence it may be suggested an association treatment with immunosoppressive agents and 2 MPG.
D000603:Amino Acids, Sulfur / Q000627:therapeutic use*; D000818:Animals; D002908:Chronic Disease; D003601:Cytotoxicity Tests, Immunologic; D006509:Hepatitis B / Q000188:drug therapy / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects*; D011817:Rabbits; D008625:Tiopronin / Q000627:therapeutic use*
D000603:Amino Acids, Sulfur; D006514:Hepatitis B Surface Antigens; D007166:Immunosuppressive Agents; D008625:Tiopronin
Effetto della 2 mercaptopropionilglicine (2 MPG) sull'attività citotossica contro epatociti di coniglio isolati e coltivati in vitro dei linfociti di soggetti con epatite cronicaz attiva.