The relationship between the carcinogenicity and mutagenicity of nitrosamines in a hepatocyte-mediated mutagenicity assay.
A quantitative relationship was established for 26 nitrosamines between their carcinogenic effectiveness in experimental animals and their mutagenic activity in a mammalian cell-mediated assay. Mutagenesis was measured in Chinese hamster V79 cells co-cultivated with primary rat hepatocytes, which are capable of activating nitrosamines. Resistance to ouabain and to 6-thioguanine served as the genetic markers.
D000818:Animals; D002273:Carcinogens; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D008099:Liver / Q000166:cytology / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D009602:Nitrosamines / Q000633:toxicity*
D002273:Carcinogens; D009153:Mutagens; D009602:Nitrosamines