Dose-dependent effects of vinyltoluene inhalation on non-protein thiols and drug biotransformation in liver and kidneys of the rat.
1. Male Wistar rats were exposed to atmospheres of 50, 100 or 300 p.p.m vinyltoluene 6h/day, 5 days/week, for one or two weeks. 2. Hepatic non-protein sulphydryl content decreased in a dose-dependent manner when measured 0.5 h after the last exposure, both after one and two weeks. 3. The content of hepatic non-protein sulphydryl groups progressively increased 20 h after stopping the vinyltoluene exposure. 4. The activity of 7-ethoxycoumarin O-deethylase showed a dose-dependent increase both in liver and kidneys. The activity of UDP-glucuronosyltransferase also increased in a dose-related manner in both organs studied.
D000818:Animals; D001711:Biotransformation; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D013343:Styrenes / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000378:metabolism*
D004364:Pharmaceutical Preparations; D013343:Styrenes; D013438:Sulfhydryl Compounds; C027142:vinyltoluene; D006899:Mixed Function Oxygenases; D005978:Glutathione