Serum and urine concentrations of 5-methoxypsoralen after oral administration.
Serum and urine concentrations were measured after oral administration of 5-methoxypsoralen (0.6 mg/kg or I.2 mg/kg) to psoriasis patients. A dose of 0.6 mg/kg resulted in low serum concentrations, but after I.2 mg/kg, much higher serum concentrations were reached. There was much individual variation in the time required for reaching peak serum levels. Minute amounts of unchanged 5-methoxypsoralen were excreted in urine. Much larger amounts were excreted as conjugates.
D000078223:5-Methoxypsoralen; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008730:Methoxsalen / Q000008:administration & dosage / Q000097:blood* / Q000652:urine; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000652:urine; D013997:Time Factors
D000078223:5-Methoxypsoralen; D008730:Methoxsalen