Plasma cortisol concentrations after oral substitution of cortisone in the fasting and non-fasting state.
Nine corticosteroid-substituted patients received oral cortisone acetate in the fasting state and together with a breakfast meal. Plasma cortisol concentrations were determined before, after 30 min, and at 1-hour intervals until 6 hours after drug ingestion. There were great interindividual variations in the time to peak values (tmax), the peak concentrations (Cmax), and the areas under the time-concentration curves (AUC0--6h). The AUC and Cmax values were significantly increased when cortisone tablets were ingested with food compared to the values obtained in the fasting state (p less than 0.01 and p less than 0.05 respectively), whereas tmax values were not significantly different. The differences were minor and probably without clinical implications.
D000224:Addison Disease / Q000097:blood / Q000188:drug therapy; D000284:Administration, Oral; D000315:Adrenalectomy; D000328:Adult; D000368:Aged; D003348:Cortisone / Q000008:administration & dosage* / Q000494:pharmacology; D005215:Fasting; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged
D003348:Cortisone; D006854:Hydrocortisone