title: Responses of elderly subjects to monovalent A/USSR/77 (H1N1) and Trivalent A/USSR/77 (H1N1)-A/TEXAS/77 (H3N2)-B/Hong Kong/72 vaccines.
abstract: Antibody responses to vaccination with monovalent A/USSR/77 (H1N1) and trivalent A/USSR/77 (H1N1)-A/Texas/77 (H3N2)-B/Hong Kong/72 vaccines were examined in a group of elderly persons most of whom had received more than 1 influenza vaccination in the previous 5 yr. Seventy-two per cent had a fourfold or greater increase in hemagglutination inhibition (HA1) titer to A/USSR and 92% had postvaccine titers equal to or greater than 1:40. There were no differences in antibody responses to A/USSR between recipients of monovalent and trivalent vaccines. No booster effect of a second injection of A/USSR was observed in subjects who had failed to respond to the first injection. Although there was a significant correlation between postvaccine HAI titers to A/USSR and to A/Texas, the responses to A/Texas and B/Hong Kong were modest or minimal compared with those to A/USSR. This serologic data may be relevant to the results of surveillance studies that suggest a limited advantage of repeated vaccinations with H3N2 subtypes and should help in evaluating the results of this practice.
mesh_terms: D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007117:Immunization, Secondary; D053118:Influenza A Virus, H1N1 Subtype; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007251:Influenza, Human / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines