[Distribution of heparin and its complex compounds in the tissues of animals maintained on an atherogenic diet following intravenous administration of a thromboplastin-heparin complex].
After intravenous infusion of the thromboplastin-35- S-heparin complex into rats, maintained on the atherogenic diet within a prolonged period, distribution of the label in the animal tissues and its clearance were studied; total and non-enzymatic fibrinolytic activities were estimated. Inhibition of functions of the anticoagulation system, caused by long-term atherogenic diet in the animals, led to inhibition of the initial steps of heparin clearance as well as to alteration of the glycosaminoglycan distribution in various tissues. At the same time, formation and accumulation of heparin complexes as well as the non-enzymatic fibrinolytic activity were decreased in some tissues.
D000818:Animals; D004036:Diet, Atherogenic; D006493:Heparin / Q000378:metabolism*; D008297:Male; D051381:Rats; D013925:Thromboplastin / Q000378:metabolism*; D014018:Tissue Distribution
D006493:Heparin; D013925:Thromboplastin
Raspredelenie geparina i ego kompleksnykh soedineniĭ v tkaniakh zhivotnykh, soderzhavshikhsia na aterogennoĭ na aterogennoĭ diete, pri vnutrivennom vvedenii im kompleksa tromboplastin-geparin.