The bioavailability of erythromycin stearate versus enteric-coated erythromycin base when taken immediately before and after food.
1. Erythromycin plasma concentrations were determined in twenty subjects after a single dose, immediately before food, of erythromycin, 500 mg. as: (1) erythromycin stearate (Erythrocin, 500 mg, ovaloid tablets), and (2) erythromycin base (Eryc, 250 mg, capsules containing enteric-coated pellets). 2. Plasma concentrations were again determined in eighteen of the original subjects with the same dose given immediately after food. 3. Maximum Plasma Concentrations (mcg/ml) (See formula in text) 4. Erythromycin stearate was more bioavailable than erythromycin base when administered immediately before food. The preparations were bioequivalent when given immediately after food.
D001682:Biological Availability; D004334:Drug Administration Schedule; D004917:Erythromycin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood*; D005502:Food; D006801:Humans; D013608:Tablets, Enteric-Coated; D013997:Time Factors
D013608:Tablets, Enteric-Coated; D004917:Erythromycin; C011462:erythromycin stearate