[Toxicological study on the anorectal irritation and systemic organ toxicity evoked by long-term intrarectal administration of ketoprofen in rabbits (author's transl)].
Ketoprofen (KP) was administered intrarectally and perorally to rabbits weighing approximately 3 kg of both sexes for a period of 13 weeks, in order to study the anorectal irritation and chronic systemic organ toxicity of KP which was capsulated with the soft T10 capsule for rectal administration and with a hard capsule for peroral administration. Doses of capsulated drugs for one animal were 9.0 mg and 4.5 mg in terms of KP. All animals treated by these dose levels survived without showing any abnormal symptoms. Intrarectal administration of KP-T10 did not produce any mucosal lesions in digestive tracts, while peroral administration of KP with hard capsule induced ulcers in cecum or anus, and congestion in small intestines in a small number of cases. No pathological change was recognized in organs except for digestive tracts in all cases by autopsy. From the above results, it can be seen that the suppository of KP capsulated by the soft T10 does not show any irritating effect on anorectal mucosa and has no toxic effect on all organs systemically. Then, a suppository of KP-T10 can be used more harmlessly than the peroral capsulated KP.
D001003:Anal Canal / Q000187:drug effects*; D000818:Animals; D005260:Female; D007413:Intestinal Mucosa / Q000187:drug effects; D007660:Ketoprofen / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D010666:Phenylpropionates / Q000633:toxicity*; D011817:Rabbits; D012007:Rectum / Q000187:drug effects*; D013488:Suppositories
D010666:Phenylpropionates; D013488:Suppositories; D007660:Ketoprofen