title: The effect of dietary fructose and diabetes on the rat kidney.
abstract: To determine whether the fructose moiety of sucrose or the lack of some factor essential for the integrity of the microvascular system is responsible for the development of sucrose-induced glomerulosclerosis, a series of diets with or without such a factor and/or fructose was fed to rats over a 6-month period. Consumption of diets containing or yielding fructose caused a significant increase in kidney weight in comparison with glucose-yielding diets. Diabetic animals also exhibited an increased kidney weight. The incidence of diffuse glomerulosclerosis, tubular damage and lymphocyte infiltration was increased in the starch-diabetic, fructose- and sucrose-normal groups. Diabetic MRC 41B- and normal MRC 41B/fructose-, MRC 41B-, glucose- and starch-fed rats (with the exception of one animal in the latter group) did not develop these kidney lesions. Sucrose-, in comparison with starch-ingestion was found to produce significant increases in blood fructose and kidney fructose-1-phosphate concentration. The results are discussed in relation to blood-glucose concentration, renal-fructose metabolism and the development of glomerular and tubular damage.
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000473:pathology; D003928:Diabetic Nephropathies / Q000473:pathology; D004040:Dietary Carbohydrates / Q000009:adverse effects*; D005632:Fructose / Q000633:toxicity*; D005636:Fructosephosphates / Q000378:metabolism; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D007668:Kidney / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004040:Dietary Carbohydrates; D005636:Fructosephosphates; C032284:fructose-1-phosphate; D005632:Fructose