Compression properties of granulations made with binders containing different moisture contents.
The role of the granulation moisture content on compression properties of granules made with selected binders was studied. The results suggested that, at lower pressures, higher moisture-containing granules were slightly more compressible than lower moisture-containing granules. However, at higher pressures, the reverse was true because of the water lubrication effect. At lower moisture levels, the crushing strength of the tablets was dependent on the binder; at higher moisture levels, binder differences became less significant.
D004339:Drug Compounding; D005079:Excipients; D006244:Hardness; D006813:Humidity; D011208:Powders; D011312:Pressure; D011725:Pyridines; D013607:Tablets; D013876:Thiophenes; D013988:Ticlopidine
D005079:Excipients; D011208:Powders; D011725:Pyridines; D013607:Tablets; D013876:Thiophenes; D013988:Ticlopidine