Oral clotrimazole in the treatment of esophageal candidiasis.
Several antifungal regimens had failed to relieve severe, recurrent esophageal candidiasis in a 75 year old woman without predisposing disease whose serum transiently inhibited the candidacidal capacity of her polymorphonuclear leukocytes. Treatment with oral nystatin suspension was unsuccessful, whereas intravenous amphotericin B and miconazole induced only transient responses. Oral 5-fluorocytosine induced severe nausea and vomiting, and was discontinued. Oral clotrimazole troches produced prompt and sustained eradication of the patient's candidal esophagitis.
D000284:Administration, Oral; D000368:Aged; D002177:Candidiasis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D003022:Clotrimazole / Q000008:administration & dosage / Q000627:therapeutic use*; D004941:Esophagitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D004947:Esophagus / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D011859:Radiography
D007093:Imidazoles; D003022:Clotrimazole