title: Comparative dissolution rate studies of commercial furosemide tablets.
abstract: Five commercial brands of furosemide tablets from different manufacturers, namely, S, F, Ls, L and Fr were elected for this study. The dissolution rate studies of these brands demonstrated vast differences in drug release characteristics. Only two batches of Fr and one batch of F brands fulfilled the U.S.P. dissolution test, while the other failed to meet the requirements of this test. The dissolution rate studies of different batches the same commercial brand showed a larger interlot variation within certain brands. These interlot variations were by far smaller than the dissolution rate differences between the different brands. Studies on the drug content for each furosemide brand showed a great variation between the brands and also within the different batches of the same brand.
mesh_terms: D002626:Chemistry, Pharmaceutical; D005665:Furosemide / Q000032:analysis; D007700:Kinetics; D012995:Solubility; D013607:Tablets; D013997:Time Factors
chemical_list: D013607:Tablets; D005665:Furosemide