[Increase of heterogeneities at the interface of decrement conduction in Hodgkin-Huxley model].
Spatial heterogeneity was simulated by a 2-fold increase in either of gNa, gK, g1 in the central part of the fibre. The interval-dependent conduction block was not observed in the cable with normal gNa, while the uniform decrease in gNa along the fibre resulted were the block appearance. Difference in the refractory period of these parts of the fibre were the higher, the lower was gNa. The mechanism of this phenomenon was investigated. The results obtained can be used for understanding the mechanism of post infarction arrhythmias.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D006339:Heart Rate; D008954:Models, Biological; D009119:Muscle Contraction; D009200:Myocardial Contraction
Rost neodnorodnosteĭ na granitse oblasti dekrementnogo provedeniia v modeli Hodgkin-Huxley.