[Clinical studies of the erythrocytosis produced by a new hemoglobin with oxygen affinity : Hb Hôtel-Dieu alpha 2A beta 2 Asp replaced by Gly (author's transl)].
A new case of erythrocytosis associated with a high oxygen affinity hemoglobin is reported : the substitution of beta 99 of aspartic acid by glycine, characterized this abnormal hemoglobin, named "hemoglobin Hôtel-Dieu". An important associated smoking habit, probably responsible of an abnormal lung X-ray and of a disturbed CO transport, contributed to increase the difficulty of diagnosis. Familial inquiry, the search of an abnormal hemoglobin by standard or isoelectrofocusing electrophoresis, and the 2,3-DPG assay should be systematically performed in case of polycythemia in young people or in the absence of obvious aetiology. A corpuscular abnormality can be thus detected in about 10 p. cent of such polycythemias.
D000328:Adult; D055598:Chemical Phenomena; D002621:Chemistry; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006801:Humans; D008297:Male; D011086:Polycythemia / Q000097:blood* / Q000175:diagnosis
D006455:Hemoglobins, Abnormal; C028905:hemoglobin Hotel-Dieu
Polyglobulie par hémoglobine anormale hyperaffine pour l'oxygène : l'hémoglobine Hôtel-Dieu alpha 2 A beta 2 99 Asp replaced by Gly.