Sialic acid metabolism in regenerating rat liver.
Sialic acid metabolism was investigated in control rat liver, in regenerating liver at 24 h and 48 h after partial hepatectomy and in the liver of sham-operated animals. High levels of membrane-bound neuraminidase, with no detectable changes in the soluble enzyme, were observed in regenerating rat liver. The neuraminidase activities in the liver of sham-operated rats were identical to those present in control liver. High levels of CMP-N-acetylneuraminic acid synthetase and sialyltransferase were observed both in regenerating liver as well as in the liver of sham-operated rats. The sialic acid content of regenerating rat liver, which was lower than that found in the liver of control and sham-operated rats at 24 h, returned to normal values 48 h after surgery.
D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D006498:Hepatectomy; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D008115:Liver Regeneration; D008297:Male; D000216:N-Acylneuraminate Cytidylyltransferase / Q000378:metabolism; D009439:Neuraminidase / Q000378:metabolism; D051381:Rats; D012794:Sialic Acids / Q000378:metabolism*; D012799:Sialyltransferases / Q000378:metabolism; D013997:Time Factors
D012794:Sialic Acids; D012799:Sialyltransferases; D000216:N-Acylneuraminate Cytidylyltransferase; D009439:Neuraminidase