title: Studies on SF=1902 A2  A5, minor components of SF-1902 (globomycin).
abstract: Four members of globomycin, SF-1902 A2, A3, A4a and A4b were newly isolated from the culture of Streptomyces hygroscopicus SF-1902. These minor components shared four amino acids in common and the fifth was either valine or allo-isoleucine. The fatty acid moiety varied from 3-hydroxy-2-methylheptanoic acid in A2 to 3-hydroxy-2-methylundecanoic acids in A4b. The length of alkyl chain greatly affected the antibacterial activity, and maximum activity was shown by the homologue (A5) possessing the longest alkyl chain.
mesh_terms: D000107:Acetylation; D000596:Amino Acids / Q000032:analysis; D000900:Anti-Bacterial Agents; D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D005227:Fatty Acids / Q000032:analysis; D005285:Fermentation; D006900:Hydroxylation; D013058:Mass Spectrometry; D010452:Peptide Biosynthesis; D010455:Peptides / Q000032:analysis
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D010455:Peptides; C017339:globomycin