Chronic starvation impairs the effect of depressant drugs on CNS of rats.
Rats starved for 70 days, i.e. receiving 60% of food ingested by control rats, showed a shortened sleeping time after ethanol and pentobarbital and a reduction of the catatonic response to haloperidol. Conversely, acute 24 h food deprivation increased barbiturate and ethanol sleeping time but did not effect the catatogenic action of haloperidol.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects; D013217:Starvation / Q000503:physiopathology*
D002492:Central Nervous System Depressants; D000431:Ethanol; D010424:Pentobarbital; D006220:Haloperidol