[Changes in the cholesterol metabolism of rats following sympathetic and parasympathetic denervation of the liver].
The rate of cholesterol biosynthesis from 2-14C-acetate and 2-14C-mevalonate te as well as the content of cholesterol in liver tissue and blood plasma (in the fractions of atherogenic lipoproteins) were decreased after partial sympathetic denervation of rat liver tissue caused by dissection of celiac nerves. As shown by ultracentrifugation in stepwise density gradient the intermediate lipoproteins disappeared and the content of low density lipoproteins was decreased; biochemical analyses showed that the content of cholesterol was decreased in the total fractions of low and very low density lipoproteins. Parasympathetic denervation of liver tissue, after bilateral dissection of vagus nerve, showed the opposite effect: the content of cholesterol and the rate of its biosynthesis from 2-14C-acetate were increased in liver tissue, but incorporation of 2-14C-mevalonate into the total nonsaponified lipid fraction was unaltered. Content of the intermediate lipoproteins and of low density lipoproteins as well as of cholesterol in atherogenic lipoproteins were increased in blood plasma.
D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008099:Liver / Q000294:innervation* / Q000378:metabolism; D008297:Male; D010275:Parasympathetic Nervous System / Q000502:physiology*; D051381:Rats; D013562:Sympathectomy; D013564:Sympathetic Nervous System / Q000502:physiology*; D014628:Vagotomy
D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D002784:Cholesterol
Izmenenie kholesterinovogo obmena u krys pri simpaticheskoĭ i parasimpaticheskoĭ denervatsii pecheni.