[Nephropathy and nodular regenerative hyperplasia of the liver (author's transl)].
A renal biopsy performed on a young woman with proteinuria showed a nephropathy consisting of major interstitial infiltration by lipophages and thickening of the glomerular capillary walls with a large amount of "spikes". Anti-IgG, IgM, C3 and C1q sera bound themselves to the extramembranous deposits and the anti-IgM serum to the endomembranous deposits. This striking finding was associated with a regenerative nodular hyperplasia of the liver, an entity that has been observed in only about 20 cases. An underlying immunological defect was suggested by the continuous presence of a mixed cryoglobulinemia.
D000328:Adult; D000906:Antibodies / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007674:Kidney Diseases / Q000276:immunology / Q000473:pathology*; D008107:Liver Diseases / Q000276:immunology / Q000473:pathology*
D000906:Antibodies; D003176:Complement C3; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Néphropathie et hyperplasie nodulaire régénérative du foie.