[Model of thymus gland dysfunction].
The thymus dysfunction induced by different doses of lymphocyte-stimulating substance, thymozine, antilymphocyte immunoglobulin and prednisolone effect upon the hormonal-immunologic balance of the hypophyseal-thymus-adrenocortical system, was studied in guinea pigs. It was stated that thymomegalia is accompanied by intensified lymphopoiesis (mainly, owing to T-lymphocytes), somatostimulating hormone and prolactin hypersecretion by adenohypophysis and the adrenocortical glucocorticoid function inhibition. Inverse proportional changes are seen in the thymus hypoplasia. The data obtained may serve as a reliable criterion for physiology and pathology of the thymus and conjugated organs and systems.
D015062:11-Hydroxycorticosteroids / Q000378:metabolism; D000302:Adrenal Cortex / Q000503:physiopathology; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000378:metabolism; D008297:Male; D010903:Pituitary Gland, Anterior / Q000503:physiopathology; D011388:Prolactin / Q000378:metabolism; D013950:Thymus Gland / Q000002:abnormalities* / Q000503:physiopathology*; D013952:Thymus Hyperplasia / Q000503:physiopathology*
D015062:11-Hydroxycorticosteroids; D011388:Prolactin; D013006:Growth Hormone; D006854:Hydrocortisone
Modelirovanie narusheniia funktsiĭ timusa.