Ethyl nitrite. The in vivo synthesis of a mutagenic substance from tobacco smoke and ethanol.
Gas chromatography--mass spectrometry demonstrates the presence of ethyl nitrite in the breath of volunteers subjects who smoke and drink concurrently. The mutagenic compound is quantitated at the ppb level by gas chromatography with the selective electron capture detector. The compound is not detected in cases of only drinking or only smoking.
D000428:Alcohol Drinking; D001711:Biotransformation; D001944:Breath Tests; D000431:Ethanol / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D009153:Mutagens / Q000378:metabolism*; D009573:Nitrites / Q000378:metabolism*; D010947:Plants, Toxic; D012906:Smoke; D012907:Smoking; D014026:Nicotiana
D009153:Mutagens; D009573:Nitrites; D012906:Smoke; D000431:Ethanol; C032712:ethyl nitrite