[Changes in kidney enzyme activity in temporary ischemia of the extremities].
Histoenzymological changes in the kidneys of 49 dogs with temporary ischemia of posterior extremities and acute renal insufficiency were studied. The results demonstrate a definite relationship between the intensity of histoenzymological changes in the kidneys and the duration of temporary ischemia of the extremities. With 12-hour ischemia of the extremities, epitheliocytes of proximal tubules showed a decreased activity of aerobic oxidation enzymes and increased activity of glycolytic enzymes, epitheliocytes of the distal tubules showed a decreased activity of the enzymes under study. After revascularization the level of metabolism in the examined parts of nephrons decreased as confirmed by the results of quantitative assays.
D000818:Animals; D004285:Dogs; D004789:Enzyme Activation; D006614:Hindlimb / Q000098:blood supply*; D006651:Histocytochemistry; D007511:Ischemia / Q000201:enzymology*; D007668:Kidney / Q000201:enzymology*; D007672:Kidney Cortex / Q000201:enzymology; D007679:Kidney Medulla / Q000201:enzymology; D007686:Kidney Tubules, Distal / Q000201:enzymology; D007687:Kidney Tubules, Proximal / Q000201:enzymology; D010088:Oxidoreductases / Q000378:metabolism; D013997:Time Factors
D010088:Oxidoreductases
Izmeneniia aktivnosti fermentov pochek pri vremennoĭ ishemii konechnosteĭ.