Intraventricular calcitonin inhibits gastric acid secretion.
Parenteral and intracerebroventricular administration of calcitonin in rats resulted in the suppression of gastric acid secretion. This suppression also occurred in rats with insulin-induced hypoglycemia and after the administration of thyrotropin-releasing hormone. Intracerebroventricularly administered calcitonin was 1000 times more effective than parenterally administered calcitonin in suppressing gastric acid secretion. Calcitonin also inhibited the development of stress-induced ulcers in rats.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D002116:Calcitonin / Q000008:administration & dosage / Q000494:pharmacology*; D005750:Gastric Juice / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D010437:Peptic Ulcer / Q000209:etiology; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000150:complications
D002116:Calcitonin