[Kinetic analysis of induced platelet aggregation].
Two mathematic models depicting the kinetics of induced platelet aggregation are suggested. The mechanisms of platelet aggregation involving the reactions of the inductor molecules with membrane receptors and intercellular interactions of platelets are discussed. Analytical expressions depicting the changes in the amount of platelets in the aggregation population and in the course of aggregation are offered. A procedure for calculating the kinetic parameters according to the experimental data is presented. The parameters of aggregation induced by different substances are calculated with the use of computers. It has been shown that application of mathematic stimulation provides valuable information both during the study of the mechanisms and for quantitative analysis of platelet aggregation.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D004837:Epinephrine / Q000494:pharmacology; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D012701:Serotonin / Q000494:pharmacology
D012701:Serotonin; D000244:Adenosine Diphosphate; D004837:Epinephrine
Kineticheskiĭ analiz indutsirovannoĭ agregatsii trombotsitov.