Establishment of pigmented melanocyte culture strain from Harding-Passey melanoma.
A cultured cell strain of melanotic melanoma was established from Harding-Passey mouse melanoma. The established cells proliferated as a monolayer culture and actively produced melanin pigment. Under an electron microscope, these cells showed the typical characteristic features of the melanocyte. When a cell suspension was inoculated into Swiss mice, they developed typical melanocytic tumors which closely resembled the original melanomas.
D000818:Animals; D002478:Cells, Cultured; D008544:Melanocytes / Q000473:pathology*; D008545:Melanoma / Q000473:pathology*; D051379:Mice; D008815:Mice, Inbred Strains; D010858:Pigmentation