[Role of protonophore activity of oxalacetic acid in inducing Ca2+ yield from mitochondria].
It has been found earlier in Lehninger's Laboratory [24] that oxidation of endogenous PN mitochondria induced by oxalacetic acid (OAA) brings about the release of accumulated Ca2+. Analysis of possible mechanism of this phenomenon has shown that OAA has protonophore activity on mitochondria and BPM unlike the malate--the product of enzymic reduction of OAA in the presence of NAD . H. OAA-induced permeability of BPM and mitochondria membranes for H+ is observed at pH 7.5-8.0 and is insignificant at pH 7.0 and lower. Possible function of OAA as a soft uncoupler-protonophore controlled by metabolism is discussed, in particular--in connection with Ca2+ transport in mitochondria.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism; D007700:Kinetics; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010071:Oxaloacetates / Q000494:pharmacology; D051381:Rats
D010071:Oxaloacetates; D002118:Calcium
Rol' protonofornoĭ aktivnosti shchavelevouksusnoĭ kisloty v indutsirovanii vykhoda Ca2+ iz mitokhondriĭ.