title: E-C coupling during poisoning with 2,4-dinitrophenol and recovery in papillary muscle of guinea-pig: 1. Effect on the cardiac mechanical activity.
abstract: The effects of 2.4-Dinitrophenol on the mechanical activity of Guinea-pig papillary muscles were studied. 1 x 10(-4) M DNP initially potentiated the contraction and subsequently suppressed the mechanical activity in about 12 min. During the negative inotropic phase a contracture was developed. All the effects were reversible.
mesh_terms: D019297:2,4-Dinitrophenol; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003864:Depression, Chemical; D004140:Dinitrophenols / Q000633:toxicity*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D010210:Papillary Muscles / Q000187:drug effects*; D013268:Stimulation, Chemical; D014475:Uncoupling Agents / Q000633:toxicity*
chemical_list: D004140:Dinitrophenols; D014475:Uncoupling Agents; D019297:2,4-Dinitrophenol