Rapidly progressive glomerulonephritis in black children. A report of 4 cases.
Rapidly progressive glomerulonephritis in children in rare, and we have therefore described 4 cases in Black children. All had evidence of a preceding streptococcal infection and there were crescents in more than 80% of the glomeruli seen on histological examination. The dominant clinical features were oliguria or anuria in a setting of nephritis or nephrotic syndrome, with a relentless progression to chronic renal failure and death. Quadruple therapy with cyclophosphamide, steroids, heparin and dipyridamole in 3 of the patients was of no lasting benefit and was attended by severe complications. Guidelines to the monitoring of children with post-streptococcal glomerulonephritis for the early detection of this uncommon complication are given.
D000208:Acute Disease; D002648:Child; D002675:Child, Preschool; D005260:Female; D005921:Glomerulonephritis / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D013290:Streptococcal Infections