title: Circadian rhythms in hypertension.
abstract: Continuous intra-arterial blood pressure recordings have been performed in 37 untreated ambulatory hypertensive subjects, who were investigated on an outpatient basis. Hourly data analysis demonstrated a circadian variation of both blood pressure and heart rate which were highest during the morning and fell during the late afternoon to reach a nadir during sleep. Prior to waking there was an increase in blood pressure, but not heart rate; however both blood pressure and heart rate increased briskly shortly after waking. Chronic therapy with oxprenolol (in 10 patients) reduced daytime blood pressure, but had little effect during the night-time or early morning.
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002940:Circadian Rhythm; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010096:Oxprenolol / Q000627:therapeutic use; D013599:Systole / Q000187:drug effects
chemical_list: D010096:Oxprenolol