[Effect of adrenaline and thymic factor on blood coagulation and fibrinolysis in healthy and thymectomized rats].
It was discovered that adult rats develop hypercoagulation and inhibited fibrinolysis 2--4 months after thymectomy. Intramuscular injections of thymus low-molecular factor to thymectomized rats for a week made the coagulative and fibrinolytic activity of blood return to normal. After adrenaline injection, the sham-operated rats developed hypercoagulation and stimulated fibrinolysis. In thymectomized rats, fibrinolysis was stimulated far less after adrenaline injection and did not reach the levels characteristic of the sham-operated rats. The thymectomized rats given thymus factor manifested an appreciable recovery of an adequate response on the part of blood coagulation and fibrinolysis to adrenaline injection.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D004837:Epinephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D008297:Male; D051381:Rats; D013934:Thymectomy; D013950:Thymus Gland / Q000502:physiology*; D013951:Thymus Hormones / Q000494:pharmacology*
D013951:Thymus Hormones; D004837:Epinephrine
Vliianie adrenaline i faktora timusa na svertyvaemost' krovi i fibrinoliz u zdorovykh i timéktomirovannykh krys.