Childhood obsessive-compulsive disorder.
The authors collected clinical diagnostic, neurophysiological, electrophysiological, and biochemical data on 9 adolescents who had primary obsessive-compulsive disorder. The results indicate considerable descriptive validity of the syndrome in childhood and its independence from obsessional traits; however, all of the children had a history of major depressive disorder, and their sleep EEG measures resembled those of young adults with primary depressive disorder. The patients' families did not have a more consistent pattern of anxiety disorder or any other psychiatric disorder than do families of adult obsessive patients. Psycholinguistic test results showed a lack of normal laterality, which has been reported for other psychiatric illness.
D000293:Adolescent; D001792:Blood Platelets / Q000201:enzymology; D002657:Child Development; D003866:Depressive Disorder / Q000235:genetics; D004569:Electroencephalography; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000097:blood; D009638:Norepinephrine / Q000097:blood; D009771:Obsessive-Compulsive Disorder / Q000201:enzymology / Q000235:genetics / Q000523:psychology*; D011581:Psychological Tests; D012701:Serotonin / Q000097:blood; D012894:Sleep Stages / Q000502:physiology; D012917:Social Adjustment
D012701:Serotonin; D008995:Monoamine Oxidase; D009638:Norepinephrine