Effects of treatment on circadian rhythms of blood pressure.
Clinical trials of beta-blocking drugs in hypertensive subjects have shown that these drugs do not affect blood pressure significantly at night or during the early morning. Labetalol, which is a combined alpha- and beta-blocking agent, reduces mean blood pressure levels at all times. These studies strongly support the hypothesis of a circadian rhythm of alpha-receptor-mediated-sympathetic activity.
D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001262:Atenolol / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D002940:Circadian Rhythm; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D007741:Labetalol / Q000627:therapeutic use; D008790:Metoprolol / Q000627:therapeutic use; D010096:Oxprenolol / Q000627:therapeutic use
D000959:Antihypertensive Agents; D001262:Atenolol; D010096:Oxprenolol; D008790:Metoprolol; D007741:Labetalol