Effects of methysergide on some cardiovascular responses in the anaesthetized rabbit.
Methysergide (0.1-5 mg/kg i.v.) caused dose-dependent reductions in the resting heart rate of anaesthetized rabbits. Resting mean arterial blood pressure was reduced only after the maximum dose. Methysergide 5 mg/kg significantly enhanced the pressor responses to i.v. phenylephrine and enhanced the accompanying bradycardia disproportionately. There was no evidence for a central increase in baroreflex gain, so an action of methysergide on baroreceptor sensory endings is suggested as a possible explanation.
D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004558:Electric Stimulation; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008784:Methysergide / Q000494:pharmacology*; D011817:Rabbits; D012018:Reflex / Q000187:drug effects; D014630:Vagus Nerve / Q000502:physiology
D008784:Methysergide