Inhibition of evoked dopamine release by monopropionylcadaverine in vitro.
A naturally occurring diamine, cadaverine, and one of its acyl derivatives, monopropionylcadaverine, were tested for their effects on the in vitro release of endogenous dopamine from slices of the rat neostriatum. Dopamine release was allowed to occur spontaneously and was evoked by elevating the potassium concentration in the incubation medium or by electric field stimulation. Monopropionylcadaverine had no effect on spontaneous release of dopamine and little effect on potassium-evoked release of dopamine, but at concentrations as low as 10(-8) M in the medium it significantly depressed the electrically induced dopamine release.
D000818:Animals; D002103:Cadaverine / Q000031:analogs & derivatives / Q000494:pharmacology*; D003342:Corpus Striatum / Q000378:metabolism; D003959:Diamines / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D004558:Electric Stimulation; D005476:Fluphenazine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D003959:Diamines; C025477:monopropionylcadaverine; D002103:Cadaverine; D011188:Potassium; D005476:Fluphenazine; D004298:Dopamine