title: The effect of an aqueous propolis extract, of rutin and of a rutin-quercetin mixture on experimental influenza virus infection in mice.
abstract: Investigations were performed on the effect of an aqueous propolis extract, of rutin and of a rutin-quercetin mixture on experimental infection with influenza virus A/PR8/34 (H0N1) in mice. Propolis extract administered intranasally 3 hours before virus inoculation led to a reduction of the HA titers recorded in the lung suspensions from infected mice, but to no reduction in mortality or increase in mean survival length. When the extract was administered 3 hours after virus inoculation, the reduction in HA titer was accompanied by a slight decrease in mortality and increase in mean survival length, Rutin and the rutin-quercetin mixture caused an increase in both HA titer and mortality.
mesh_terms: D000818:Animals; D005419:Flavonoids / Q000627:therapeutic use*; D006389:Hemagglutinins, Viral / Q000032:analysis; D009980:Influenza A virus / Q000276:immunology; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D011429:Propolis / Q000627:therapeutic use*; D011794:Quercetin / Q000627:therapeutic use*; D012116:Resins, Plant / Q000627:therapeutic use*; D012431:Rutin / Q000627:therapeutic use*
chemical_list: D005419:Flavonoids; D006389:Hemagglutinins, Viral; D012116:Resins, Plant; D012431:Rutin; D011429:Propolis; D011794:Quercetin