Transport of small, middle, and large molecular weight substances in a dual filtration artificial kidney.
Theoretical calculations based on in vitro transport characteristics of membranes presently used in long-term clinical evaluation of a SElective DUal Filtration ARtificial Kidney (SEDUFARK) show that the system is comparable with hemofiltration in removal of urea and creatinine, and for substances greater than 15,000 daltons. Removal of middle molecular weight substances with SEDUFARK treatment is smaller or in the same region as conventional hemodialysis using cuprophane dialyzers. Analysis of G-15 chromatograms from the different in vivo SEDUFARK compartments confirmed these results, hence indicating that uremic serum contain substances larger than the middle molecular weight range which act toxic on a biological test system.
D002850:Chromatography, Gel; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D007688:Kidneys, Artificial; D007700:Kinetics; D008970:Molecular Weight; D006435:Renal Dialysis; D014118:Toxins, Biological / Q000302:isolation & purification / Q000378:metabolism*; D014511:Uremia / Q000628:therapy*
D014118:Toxins, Biological; C026865:uremia middle molecule toxins