title: [GABA-ergic component of the cerebrovascular effects of sodium hydroxybutyrate].
abstract: There are two different mechanisms that are implicated in the realization of the cerebrovascular effects of sodium hydroxybutyrate. The dilatation of the cerebral vessels and the increased blood inflow to the brain induced by the drug are not mediated via GABA receptors and are likely to be caused by the drug effect on the cerebral vessels. At the same time the central GABAergic mechanisms play an important part in the depressant effect of sodium hydroxybutyrate on the nervous regulation of cerebral circulation, since under the blockade of GABA receptors by bicuculline the characteristic inhibitory effect of the drug on the constrictor reactions of the cerebral vessels and somatosympathetic reflexes does not become manifest.
mesh_terms: D000818:Animals; D001640:Bicuculline / Q000008:administration & dosage; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004347:Drug Interactions; D006885:Hydroxybutyrates / Q000494:pharmacology*; D012978:Sodium Oxybate / Q000008:administration & dosage / Q000494:pharmacology*; D013268:Stimulation, Chemical; D014665:Vasodilator Agents; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D006885:Hydroxybutyrates; D014665:Vasodilator Agents; D005680:gamma-Aminobutyric Acid; D012978:Sodium Oxybate; D001640:Bicuculline
vernacular_title: O GAMK-ergicheskom komponente tserebrovaskuliarnogo éffekta oksibutirata natriia.