Enhancement of mutagenicity by hydroxypyrenes in Salmonella.
1-Hydroxypyrene and 4,5-dihydro-4,5-dihydro-4,5-dihydroxypyrene were isolated and identified in the metabolites of pyrene by rat liver microsomal fraction, and the presence of 1,8- and 1,6-dihydroxypyrene in the metabolites was proposed. These hydroxypyrenes, as well as pyrenequinones reported previously, enhanced intensively the mutagenicity of 2-acetylaminofluorene (AAF).
D015073:2-Acetylaminofluorene / Q000494:pharmacology*; D000818:Animals; D004357:Drug Synergism; D009153:Mutagens / Q000302:isolation & purification; D011721:Pyrenes / Q000378:metabolism* / Q000494:pharmacology*; D051381:Rats; D012475:Salmonella / Q000187:drug effects*
D009153:Mutagens; D011721:Pyrenes; D015073:2-Acetylaminofluorene; C033146:1-hydroxypyrene