The carcinogenic effect of nitrosomethyldodecylamine in European hamsters.
Laboratory-bred European hamsters received nitrosomethyldodecylamine (NMDA) subcutaneously in olive oil once weekly for life. The animals showed mainly mucoepidermoid carcinomas of the lung, carcinomas of the urinary bladder and squamous cell carcinomas and sarcomas at the injection site. The tumour incidence was 90% in males and 70% in females, while the average tumour latency was 32 +/- 6 weeks for both sexes. Males had an average survival time of 29 +/- 17 weeks and females 24 +/- 19 weeks.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D006224:Cricetinae; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009602:Nitrosamines / Q000633:toxicity*; D012737:Sex Factors; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D009602:Nitrosamines; C009914:N-nitrosomethyldodecylamine