Carbamazepine, phenytoin and phenobarbital do not influence brain catecholamine uptake, in vivo, in male rats.
Desipramine (10 mg/kg, i.p.), a specific blocker of noradrenaline uptake, significantly antagonized the decrease of brain noradrenaline induced by an intraventricular injection of 6-hydroxydopamine (200 micrograms in 20 microliter) in rats. The depletion of brain dopamine, in 6-hydroxydopamine plus pargyline-treated rats was counteracted by nomifensine (10 mg/kg, i.p.), a drug which has been reported to markedly inhibit dopamine uptake both in vivo and in vitro. Carbamazepine (10 mg/kg, i.p.), phenytoin (200 mg/kg, orally) and phenobarbital (20 mg/kg, orally) were unable to significantly affect either the decrease of noradrenaline or the depletion of dopamine induced by 6-hydroxydopamine. These findings seem to suggest that these anticonvulsant drugs do not inhibit brain catecholamine uptake in vivo in male rats.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002220:Carbamazepine / Q000494:pharmacology*; D002395:Catecholamines / Q000378:metabolism*; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D009627:Nomifensine / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology*; D010672:Phenytoin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D002395:Catecholamines; D006892:Hydroxydopamines; D009627:Nomifensine; D002220:Carbamazepine; D010672:Phenytoin; D009638:Norepinephrine; D010634:Phenobarbital