title: Determinants of response to intravenous hydralazine in hypertension.
abstract: There is marked interindividual variation in hypotensive response to intravenous hydralazine (H). We examined the determinants of response in patients with hypertension. After a single intravenous dose of 0.3 mg/kg H, response was correlated independently (r = 0.8364) with both predrug blood pressure and acetylator index (AI). Intravenous dose ranging studies showed that response also depended on the amount of H in the systemic circulation. Although plasma H levels depend on AI after oral doses, this is not so after intravenous administration. AI must therefore affect response to H by an alternative, presumably nonmetabolic mechanism which, not related to AI, perhaps indicating specificity of this effect for H. These data reinforce the potential usefulness of determining AI before giving H to a patient.
mesh_terms: D000107:Acetylation; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D014644:Genetic Variation; D006801:Humans; D006830:Hydralazine / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009599:Nitroprusside; D010641:Phenotype
chemical_list: D009599:Nitroprusside; D006830:Hydralazine