[Effect of anti-idiotypes on the production of phosphorylcholine-specific antibodies].
BALB/c mice were immunized with purified phosphorylcholine (PC)-specific myeloma proteins of the TEPC-15 and M167 tumors. After the respective isologous anti-idiotypic responses had been established, and after an additional resting period of four months, animals were immunized with phosphorylcholine-hemocyanin in a procedure normally leading to formation of IgE in addition to antibodies of other classes. The experiment shows that BALB/c mice producing (T15) anti-idiotypes depress the formation of anti-PC IgE, IgM, IgA antibodies, while stimulatory effects on the IgG response are observed. This demonstrates that IgE bears idiotypes similar or identical, to antibodies of other classes, and that anti-PC-IgE antibodies mainly bear the T15 idiotype or idiotypes crossreacting with isologous anti-T15. On the other hand, cells responsible for regulation or production of antibodies of different classes show different susceptibility to regulation by anti-idiotypes. The formation of IgE antibodies seems to be particularly susceptible to suppression by anti-idiotypes, a fact which may lead to new treatments for some allergic diseases and to new insight into the mechanisms of hyposensitization therapy.
D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D002794:Choline / Q000031:analogs & derivatives*; D006433:Hemocyanins / Q000276:immunology; D007114:Immunization; D007073:Immunoglobulin E; D007130:Immunoglobulin Idiotypes / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009194:Myeloma Proteins / Q000276:immunology*; D010767:Phosphorylcholine / Q000276:immunology*
D007130:Immunoglobulin Idiotypes; D009194:Myeloma Proteins; D010767:Phosphorylcholine; D007073:Immunoglobulin E; D006433:Hemocyanins; D002794:Choline
Effekt von Anti-Idiotypen auf die Produktion phosphorylcholin-spezifischer Antikörper.