title: [Effects of magaldrate on circadian profile of gastric juice pH in medical intensive care patients (author's transl)].
abstract: The effect of the antacid magaldrate on intragastric pH behaviour was investigated in 9 medical intensive care patients. During the 24-hour test period 10 ml of this complex preparation induced pH increases to values between 6 and 7 when it was administered every two hours. However, three-hourly administration of 15 ml magaldrate did not result in a sufficient intragastric pH increase. Thus relatively small volumes of magaldrate are sufficient to neutralize gastric acid of these intensive care patients effectively.
mesh_terms: D000536:Aluminum Hydroxide / Q000008:administration & dosage / Q000494:pharmacology*; D000863:Antacids / Q000008:administration & dosage / Q000494:pharmacology*; D005750:Gastric Juice / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007362:Intensive Care Units; D008274:Magnesium / Q000494:pharmacology*; D008276:Magnesium Hydroxide / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D013997:Time Factors
chemical_list: D000863:Antacids; D000536:Aluminum Hydroxide; C016545:magaldrate; D008274:Magnesium; D008276:Magnesium Hydroxide
vernacular_title: Wirkung von Magaldrat auf das 24-Stunden-Profil des Magensaft-pH bei internistischen Intensivpatienten.