GLC analysis of menthol, phenol, benzocaine, and pyrilamine maleate in aerosol spray lotion.
A GLC method is presented for the quantitative determination of menthol, phenol, benzocaine, and pyrilamine maleate. The propellent was exhausted from a pressurized can, and an aliquot of the alcoholic base was weighed. After the addition of the internal standard diluted with chloroform, 1 microliter of the mixture was injected in the chromatograph with a flame-ionization detector and a glass column packed with 2.5% OV-225. Average recoveries were 100.3 +/- 1.4, 100.0 +/- 1.4, 101.3 +/- 1.5, and 101.5 +/- 1.5% for menthol, phenol, benzocaine, and pyrilamine maleate, respectively.
D000336:Aerosols / Q000032:analysis; D000631:Aminopyridines / Q000032:analysis*; D001566:Benzocaine / Q000032:analysis*; D002849:Chromatography, Gas / Q000379:methods; D008610:Menthol / Q000032:analysis*; D019800:Phenol; D010636:Phenols / Q000032:analysis*; D011738:Pyrilamine / Q000032:analysis*
D000336:Aerosols; D000631:Aminopyridines; D010636:Phenols; D008610:Menthol; D019800:Phenol; D011738:Pyrilamine; D001566:Benzocaine