title: Naturally occurring inhibitors of the venom of funnel web spiders (Atrax species).
abstract: It has been shown that the blood plasma of rats and many other vertebrate species, but not man, contains a factor that inhibits the toxic actions of the venom of funnel web spiders (Atrax) on isolated toad voluntary muscle and rat lung preparations and also on anaesthetized whole rats. This factor was found to be effective against all obvious symptoms produced by the venom of both sexes of A. infensus and of the females of the other three common species of Atrax, particularly when administration of the factor to the test preparation preceded that of the venom.
mesh_terms: D000818:Animals; D001180:Arthropod Venoms / Q000037:antagonists & inhibitors*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000187:drug effects; D009498:Neurotoxins / Q000037:antagonists & inhibitors* / Q000633:toxicity; D010949:Plasma / Q000032:analysis*; D051381:Rats / Q000097:blood; D013045:Species Specificity; D013111:Spider Venoms / Q000037:antagonists & inhibitors* / Q000506:poisoning / Q000633:toxicity; D013112:Spiders
chemical_list: D001180:Arthropod Venoms; D009498:Neurotoxins; D013111:Spider Venoms