Immunological features of preeclampsia: increased frequency of antilymphocyte antibodies, but not of immune complexes.
Using two methods for detecting circulating immune complexes (CIC)--inhibition of antibody-dependent cell-mediated cytotoxicity and solid-phase C1q assay--we were unable to demonstrate CIC in sera from preeclamptic patients and from healthy pregnant women. Antilymphocyte antibodies were found much more frequently in multiparous women suffering from preeclampsia-like disease than in healthy multiparous pregnant control patients. They were not detected in primigravida uncomplicated or preeclamptic pregnancies. It is suggested, therefore, that preeclampsia may have a different etiology in the multiparous woman than in the primigravida.
D000920:Antibody-Dependent Cell Cytotoxicity; D000936:Antigen-Antibody Complex / Q000032:analysis*; D000961:Antilymphocyte Serum / Q000032:analysis*; D003172:Complement C1 / Q000032:analysis; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006801:Humans; D010298:Parity; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy
D000936:Antigen-Antibody Complex; D000961:Antilymphocyte Serum; D003172:Complement C1