[Altered plasma lipid and protein patterns in schizophrenic patients (author's transl)].
The plasma lipid and lipoprotein pattern (total cholesterol, triglycerides and total lipid concentration; electrophoretic separation of the lipoproteins) and plasma protein profile (total protein concentration; electrophoretic separation of the plasma proteins) have been determined in a group of 60 chronic schizophrenic patients (47 men and 13 women, mean age 30,3 +/- 22 years). When compared to a control group matched for age and sex, the schizophrenic patients exhibited significantly lower cholesterol concentration and altered distribution pattern of the plasma lipid fractions. Similarly, the plasma a1,- a2,- and beta-globulin patterns are also altered in schizophrenic group. It is concluded that the altered plasma lipid and protein patterns may suggest that (auto)-immunologic and/or metabolic factors may be involved in the pathogenesis of schizophrenic disease.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001798:Blood Proteins / Q000032:analysis*; D002648:Child; D002784:Cholesterol / Q000097:blood; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000097:blood*; D012712:Serum Globulins / Q000032:analysis; D014280:Triglycerides / Q000097:blood
D001798:Blood Proteins; D008055:Lipids; D012712:Serum Globulins; D014280:Triglycerides; D002784:Cholesterol
Alterazioni dell'assetto plasmatico delle componenti lipidiche e proteiche nell'esito difettuale schizofrenico.