title: Age-related changes in enzymes of rat brain. 2. Redox systems linked to NADP and glutathione.
abstract: Measurements have been made of the enzymes of glutathione metabolism and of NADPH generation in the brains of rats aged between 1 day and 24 months. The activity of glutathione peroxidase fell while that of glutathione reductase rose during the aging process. The four NADPH-generating systems each showed a different profile with respect to aging, the most marked changes occurring between 1 and 20 days. Subsequently, the systems remained close to, or above, the young adult value. The role of the glutathione-metabolising enzymes in controlling the H2O2 metabolism and suppressing peroxidative damage to the brain is discussed.
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000201:enzymology*; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000378:metabolism; D009249:NADP / Q000096:biosynthesis*; D010084:Oxidation-Reduction; D010544:Peroxidases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009249:NADP; D006861:Hydrogen Peroxide; D010544:Peroxidases; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione