Chronic intravenous administration of lentinan to the rhesus monkey.
The prolonged effects of overdosage with lentinan in the rhesus monkey are associated with foam cell reactions in lung, liver, kidney, spleen, lymph nodes and bone marrow and with varying degrees of vasculitis and associated reactions. A dose level of 0.5 mg/kg/day was without adverse effect.
D000818:Animals; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D005260:Female; D007275:Injections, Intravenous; D007912:Lentinan / Q000008:administration & dosage / Q000633:toxicity*; D008253:Macaca mulatta; D008297:Male; D009092:Mucous Membrane / Q000187:drug effects; D009929:Organ Size; D011134:Polysaccharides / Q000633:toxicity*; D012877:Skin Manifestations
D011134:Polysaccharides; D007912:Lentinan