Reduction of venous sequelae of i.v. diazepam with a fat emulsion as solvent.
Venous sequelae were studied in 93 female patients undergoing minor gynaecological procedures. They were premedicated with diazepam i. v. dissolved in a fat emulsion (Diazemuls) injected to a superficial vein of the right hand. The patients observed the site of injection for 14 days and recorded their findings. Twenty-eight per cent reported mild tenderness and 7.5% mild or moderate swelling of short duration. Signs of thrombophlebitis were found in 2.2%. Thrombophlebitis after injection can be prevented effectively and safely using fat emulsion as a solvent for diazepam.
D000293:Adolescent; D000328:Adult; D000368:Aged; D003975:Diazepam / Q000008:administration & dosage / Q000009:adverse effects*; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D011229:Preanesthetic Medication; D012997:Solvents; D013924:Thrombophlebitis / Q000139:chemically induced / Q000517:prevention & control*
D005217:Fat Emulsions, Intravenous; D012997:Solvents; D003975:Diazepam