Peripherally administered serotonin decreases food intake in rats.
We report that intraperitoneal injection of serotonin produces a dose-related decrease in the food intake of hungry rats. The efficacy of serotonin was increased by prior treatment with clorgyline, a type A monoamine oxidase inhibitor. Doses of serotonin which were anorectic did not significantly impair locomotor activity or sensorimotor performance. Further, 2 mg/kg serotonin (ED50 on food intake) did not produce a conditioned taste aversion when paired repeatedly with sucrose ingestion. We conclude that the anorectic effects of serotonin are not secondary to nonspecific effects of the agent, and suggest that peripheral serotonin may play a role in normal satiation.
D000818:Animals; D001143:Arousal / Q000187:drug effects; D001362:Avoidance Learning / Q000187:drug effects; D003864:Depression, Chemical; D004327:Drinking Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology*; D013649:Taste / Q000187:drug effects
D012701:Serotonin