Basal ganglia calcification in pseudohypoparathyroidism type II.
The case history of a patient with basal ganglia calcifications found by computerised tomography is presented. Calcium and phosphorus metabolism showed a pattern suggesting lack of parathyroid hormone (PTH). Further studies revealed increased endogenous PTH levels and urinary cAMP excretion. However, endogenous and exogenous PTH could not elicit the cAMP-mediated phosphaturic response, indicating pseudohypoparathyroidism type II. The responses of prolactin to TRH and chlorpromazine was impaired. Basal ganglia calcification in pseudohypoparathyroidism type II may represent the only somatic abnormality in this disease apart from the biochemical abnormalities.
D000293:Adolescent; D001480:Basal Ganglia Diseases / Q000175:diagnosis* / Q000209:etiology; D002114:Calcinosis / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008297:Male; D011547:Pseudohypoparathyroidism / Q000150:complications / Q000175:diagnosis*