title: Resistance to the cytocidal effects of adriamycin is an early phenotypic change induced during hepatocarcinogenesis.
abstract: Resistance to the cytocidal action of Adriamycin (ADR) was induced in rat hepatocytes by incorporation of the carcinogen 2-acetylaminofluorene (AAF) into the rat diet. Using a quantitative assay in primary monolayer culture, it was demonstrated that resistance to ADR is an early phenotypic change that is induced during chemical carcinogenesis in the rat, and appears to be stable.
mesh_terms: D015073:2-Acetylaminofluorene; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004317:Doxorubicin / Q000494:pharmacology*; D004351:Drug Resistance; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D010641:Phenotype; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D004317:Doxorubicin; D015073:2-Acetylaminofluorene