The brain stem in sudden infant death syndrome. A postmortem survey.
Abnormal central neural regulation of respiration may be involved in the pathogenesis of the sudden infant death syndrome (SIDS). A retrospective investigation of brain-stem morphology in 34 SIDS victims compared to well-matched controls revealed medullary gliosis in the reticular formation in 12% and a single microglial nodule suggestive of a viral infection in one infant. These findings support the need for more extensive prospective neuropathological investigations in SIDS utilizing more sophisticated techniques.
D001344:Autopsy; D001933:Brain Stem / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D013398:Sudden Infant Death / Q000473:pathology*