New anthracycline metabolites from mutant strains of Streptomyces galilaeus MA144-M1. II. Structure of 2-hydroxyaklavinone and new aklavinone glycosides.
Four blocked mutants of aclacinomycin-producing Streptomyces galilaeus MA144-M1 produced new anthracyclinones; 2-hydroxyaklavinone, its non-esterified analog and 2-hydroxy-7-deoxyaklavinone, several new anthracyclines; 2-deoxyfucosyl-2-deoxyfucosyl-rhodosaminylaklavinone (MA144 U1), 2-deoxyfucosyl-rhodosaminylaklavinone (MA144 U2) and five aklavinone glycosides devoid of amino sugar, designated as MA144 U5, U6, U7, U8 and U9.
D018943:Anthracyclines; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002621:Chemistry; D006027:Glycosides / Q000302:isolation & purification; D009154:Mutation; D009279:Naphthacenes / Q000302:isolation & purification*; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism*
D018943:Anthracyclines; D000900:Anti-Bacterial Agents; D006027:Glycosides; D009279:Naphthacenes; C027832:aklavinone; C033382:2-hydroxyaklavinone