title: Morphine conditioned taste aversion reversed by periaqueductal gray lesions.
abstract: The role of the periaqueductal gray (PAG) in morphine conditioned taste aversion (CTA) was studied using male Wistar rats as subjects. Following the presentation of a novel saccharin solution, animals with or without a lesion of the PAG were intraperitoneally injected with either morphine, lithium, ethanol or fenfluramine. As evident by the amount of saccharin solution consumed on a subsequent presentation, a PAG lesion reversed a morphine CTA but not CTAs produced by the other drugs used. The results suggest that the PAG may in part mediate morphine CTA.
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001921:Brain / Q000502:physiology*; D003913:Dextroamphetamine / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D005277:Fenfluramine / Q000494:pharmacology; D008094:Lithium / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste / Q000187:drug effects*
chemical_list: D005277:Fenfluramine; D000431:Ethanol; D009020:Morphine; D008094:Lithium; D003913:Dextroamphetamine