Effect of mersalyl at cholinoceptive sites.
The effects of an organic mercurial compounds, mersalyl, were tested at the muscarinic and nicotinic sites (the smooth muscles, frog heart and frog rectus muscle) in vitro. Mersalyl had an antimuscarinic effect in the smooth muscle tissues and in the myocardium. On the frog rectus muscle, mersalyl had some potentiating effect on acetylcholine response.
D000818:Animals; D001001:Anura; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D008634:Mersalyl / Q000494:pharmacology*; D009130:Muscle, Smooth / Q000187:drug effects; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009941:Organomercury Compounds / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects*
D009941:Organomercury Compounds; D011950:Receptors, Cholinergic; D008634:Mersalyl