Structural requirement of sterol side chain for the silkworm growth and development.
Several cholesterol analogs with modifications in the side chain were added to the artificial diet of the silkworm, and their effects on insect growth and development were determined. It was found that slight deviations of the cholesterol's side chain induced pronounced growth-retarding effects, suggesting an important functional role of the isooctane side chain of cholesterol.
D000818:Animals; D012831:Bombyx / Q000187:drug effects / Q000254:growth & development*; D002784:Cholesterol / Q000031:analogs & derivatives; D007814:Larva / Q000502:physiology; D013261:Sterols / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D013261:Sterols; D002784:Cholesterol