[Effect of human chorionic gonadotropin on proliferation of hepatocyte organelles of normal and pathologically altered rat livers].
The effects of human chorionic gonadotropin on the proliferation of hepatocyte organelles in the normal and pathologically changed rat liver were studied and compared. Hepatitis was induced by 20-fold infusion of CCl4. The electron microscopy data obtained immediately, 12 and 48 hours after one or two injections of the hormone were assessed by morphometry with the use of regression analysis. It was disclosed that application of chorionic hormone entailed the augmentation of granular and agranular reticulum proliferation in hepatocytes. The sick and normal animals manifested differences in the time course and activity of the proliferation.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000473:pathology; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D008099:Liver / Q000648:ultrastructure*; D008930:Mitochondria, Liver / Q000648:ultrastructure; D051381:Rats; D013997:Time Factors
D006063:Chorionic Gonadotropin
Deĭstvie khorionicheskogo gonadotropina cheloveka na proliferatsiiu oranell gepatotsitov normal'noĭ i patologicheski izmenennoĭ pecheni krys.