[Experimental approach to the treatment of lupus nephritis by use of an accelerated model of the NZBxNZW mouse disease (author's transl)].
An accelerated model of the NZBxNZW mouse disease is described. The acceleration of the disease was induced by the simultaneous injections of DNA complexed to methylated bovine serum albumin and of bacterial lipopolysaccharide which allow for the production, early in life, of high levels of anti-DNA antibodies. This new model was found to be suitable for therapeutic studies in mice with accelerated disease treated with cyclophosphamide and heparin.
D000818:Animals; D002417:Cattle; D003520:Cyclophosphamide / Q000627:therapeutic use; D004247:DNA / Q000276:immunology / Q000494:pharmacology; D004195:Disease Models, Animal; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000188:drug therapy; D006493:Heparin / Q000627:therapeutic use; D051379:Mice; D008815:Mice, Inbred Strains; D009393:Nephritis / Q000188:drug therapy; D011135:Polysaccharides, Bacterial / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000494:pharmacology
D011135:Polysaccharides, Bacterial; D012710:Serum Albumin, Bovine; D003520:Cyclophosphamide; D006493:Heparin; D004247:DNA
Approche expérimentale du traitement des glomérulonéphrites lupiques à l'aide d'un modèle accéléré de la maladie des souris NZBxNZW.