Comparison of outward and inward Na+/K+ cotransport-mediated fluxes in erythrocytes of essential hypertensive patients. Preliminary results.
A hereditary defect in the outward ouabain-resistant, furosemide-sensitive (ORFS) Na+/K+ cotransport has recently been reported by Garay and Meyer in erythrocytes of essential hypertensive patients and some of their normotensive offsprings. Since Na+/K+ cotransport in erythrocytes operates bidirectionally, the same defect might be detectable in the ORFS component of K+ influx rate. To test this hypothesis outward and inward Na+/K+ cotransport measurements were performed in erythrocytes of hypertensives and normotensive controls. Our preliminary results confirm the observation of a reduced outward cotransport in essential hypertension and also suggest that inward cotransport may be reduced in essential hypertension.
D000328:Adult; D001693:Biological Transport, Active / Q000187:drug effects; D004912:Erythrocytes / Q000378:metabolism*; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000235:genetics; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000097:blood*; D012964:Sodium / Q000097:blood*
D010042:Ouabain; D005665:Furosemide; D012964:Sodium; D011188:Potassium