[The influence of cyclophosphamide upon the healing of fractures in the rabbit (author's transl)].
The influence of cyclophosphamide (Ctx) upon the healing of fractures in the femur of the rabbit is reported. During treatment with Ctx the x-ray shows a reduced callus-formation; the fluorescence-microscopy reveals a decreased apposition of bone. Fracture-load, fracture-energy and mineral content of the intact bone are not influenced by Ctx. Four weeks after an operation fracture-load and fracture-energy are reduced almost by one half and the mineral content is decreased significantly.
D000818:Animals; D002146:Bony Callus / Q000187:drug effects*; D003520:Cyclophosphamide / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005264:Femoral Fractures / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005269:Femur / Q000032:analysis; D008856:Microscopy, Fluorescence; D008903:Minerals / Q000032:analysis; D011817:Rabbits; D011859:Radiography; D014945:Wound Healing / Q000187:drug effects*
D008903:Minerals; D003520:Cyclophosphamide
Der Einfluss von Cyclophosphamid auf die Knochenbruchheilung am Kaninchenfemur.