A fatality during haloperidol treatment: mechanism of sudden death.
The authors report a case of unexpected sudden death in a woman receiving relatively high dose of haloperidol. They postulate that drug-induced laryngeal spasm leading to cardiac arrest via vagal reflexes may represent the mechanism of neuroleptic sudden death in some cases.
D000328:Adult; D003645:Death, Sudden / Q000209:etiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006220:Haloperidol / Q000009:adverse effects* / Q000627:therapeutic use; D006323:Heart Arrest / Q000139:chemically induced; D006801:Humans; D007826:Laryngismus / Q000139:chemically induced; D012563:Schizophrenia, Paranoid / Q000188:drug therapy*
D006220:Haloperidol