[Interaction between benzene and toluene in long term inhalation exposure in rats (author's transl)].
Industrial chemicals are seldom used as pure substances; hazards resulting from exposure to mixtures have, however not been solved. Our study deals with chronic inhalation toxicity of a mixture of benzene and toluene; few studies have been completed on this subject. Our results show: - leucopenia with benzene alone, at a concentration of 50 p.p.m., that is not detectable in the presence of toluene; - metabolic variations consisting in: a decrease in the phenol urinary rate versus time with benzene alone; a sharp decrease of this rate from the third month of exposure on, in presence of toluene.
D000818:Animals; D001554:Benzene / Q000633:toxicity* / Q000652:urine; D001711:Biotransformation; D001772:Blood Cell Count; D005260:Female; D005740:Gases; D008297:Male; D010636:Phenols / Q000652:urine; D051381:Rats; D013997:Time Factors; D014050:Toluene / Q000633:toxicity* / Q000652:urine
D005740:Gases; D010636:Phenols; D014050:Toluene; D001554:Benzene
Etude toxicologique chronique par inhalation chez le rat de l'association benzène - toluène.