Subunit assembly of hemoglobins A and S.
It has been demonstrated that a difference in affinities of beta A and beta S chains for alpha chains exists. Furthermore, differential rates of dissociation of beta A and beta S chain tetramers have also been measured. It appears that the overall assembly of Hb A and Hb S, in vitro, can be governed by either the dissociation or combination reactions of its non-alpha-subunit.
D006441:Hemoglobin A / Q000378:metabolism*; D006451:Hemoglobin, Sickle / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D046911:Macromolecular Substances; D010108:Oxyhemoglobins / Q000378:metabolism; D013053:Spectrophotometry; D014316:Tritium
D006451:Hemoglobin, Sickle; D046911:Macromolecular Substances; D010108:Oxyhemoglobins; D014316:Tritium; D006441:Hemoglobin A