title: Delayed neurotoxicity caused by a single massive dose of dichlorvos to adult hens.
abstract: A moderate neuropathic response was obtained in hens 2 weeks after being given a single massive s.c. dose of dichlorvos (100 mg/kg of active ingredient in a commercial 50% formulation). 1 day after dosing inhibition of neurotoxic esterase in peripheral nerve was 79-90%, in spinal cord 70-81% and in brain 89-92%. It is unlikely that repeated exposure of man to dichlorvos could cause neuropathy except at doses causing severe cholinergic effects at every exposure.
mesh_terms: D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000633:toxicity; D002645:Chickens; D004006:Dichlorvos / Q000506:poisoning*; D005260:Female; D009422:Nervous System Diseases / Q000139:chemically induced*; D010525:Peripheral Nerves / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects
chemical_list: D004006:Dichlorvos; D002265:Carboxylic Ester Hydrolases; C021859:neurotoxic esterase