[Growth stimulation in a Ewing sarcoma after "macrophage blockade" in athymic (nude) mice].
Inoculation of cell suspensions of a Ewing sarcoma (1.5 to 2.0 x 10(8) viable cells/mouse) into thymus less nude mice bred under conventional conditions gave a 90% take rate after subcutaneous injection and 35% after intraperitoneal. Intraperitoneal take rate is raised to 90% by intraperitoneal pretreatment with India ink. The same pretreatment shortens the tumor doubling time after subcutaneous inoculation. Both events are probably caused by inhibition of macrophages and/or natural killer cells.
D000293:Adolescent; D000818:Animals; D006801:Humans; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D007694:Killer Cells, Natural / Q000503:physiopathology; D008264:Macrophages / Q000503:physiopathology; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D012512:Sarcoma, Ewing; D014183:Transplantation, Heterologous
Wachstumsstimulaton eines Ewing-Sarkoms nach "Makrophagen-Blockade" in thymuslosen (nude) Mäusen.