E-C coupling during poisoning with 2,4-dinitrophenol and recovery in papillary muscle of guinea-pig: 2. Effect on the cardiac electrical activity.
-DNP (1 x 10(-4)M) reduced membrane resting potential, overshoot, rate of depolarization, conduction velocity, action potential plateau, twitch tension and increased the passive base tension. -All the electrical and mechanical effects were reversed by the wash out. -The results are consistent with an inhibition of the ion active transport by the membrane Na+-K+ pump and the SR Ca++ pump.
D019297:2,4-Dinitrophenol; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003864:Depression, Chemical; D004140:Dinitrophenols / Q000633:toxicity*; D004558:Electric Stimulation; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D010210:Papillary Muscles / Q000187:drug effects*; D013268:Stimulation, Chemical; D014475:Uncoupling Agents / Q000633:toxicity*
D004140:Dinitrophenols; D014475:Uncoupling Agents; D019297:2,4-Dinitrophenol