title: Chronic neutropenia: possible association with Sjögren's syndrome.
abstract: Three white males, ages 42-59, with chronic neutropenia are described. All 3 patients had splenomegaly, positive tests for rheumatoid factor, elevated erythrocyte sedimentation rates, hypergammaglobulinemia and bone marrow examinations which showed normal to increased cellularity. Two of the 3 patients had recurring arthralgias and positive tests for antinuclear antibodies. All 3 patients had evidence for decreased tearing suggestive of Sjogren's syndrome, but in only 1 patient was a positive lip biopsy obtained. One patient had repeated cutaneous infections which ceased after splenectomy resulted in an increased neutrophil count. Serum IgG neutrophil-binding and in vivo neutrophil kinetic studies on 1 patient were consistent with a humoral immune mechanism for his neutropenia.
mesh_terms: D000328:Adult; D000380:Agranulocytosis / Q000150:complications*; D000961:Antilymphocyte Serum / Q000032:analysis; D002908:Chronic Disease; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000097:blood / Q000150:complications*; D009504:Neutrophils / Q000502:physiology; D012859:Sjogren's Syndrome / Q000150:complications*
chemical_list: D000961:Antilymphocyte Serum; D007074:Immunoglobulin G