Factors affecting the distribution of tobacco smoke-induced lesions in the rodent larynx.
Tobacco smoke-induced laryngeal lesions were investigated in rats and hamsters exposed for up to 12 weeks. The distribution of epithelial hyperplasia and squamous metaplasia was non-uniform in both species. The influence of laryngeal anatomy, histology (epithelial type) and airflow, together with the characteristics of the smoke itself, on the distribution of these lesions, are discussed.
D000818:Animals; D006224:Cricetinae; D007818:Laryngeal Diseases / Q000139:chemically induced / Q000473:pathology*; D008647:Mesocricetus; D051381:Rats; D011919:Rats, Inbred Strains; D012907:Smoking; D013045:Species Specificity