Dopamine receptor blockade induced by metoclopramide and thyroid-stimulating hormone secretion in man.
20 mg metoclopramide, intramuscularly administered to 10 healthy males and 10 healthy females, induced a significant increase in serum thyroid-stimulating hormone values in female subjects only. This finding suggests that dopamine does not play a major role in the regulation of thyroid-stimulating hormone secretion and that estrogens can act in the modulation of dopamine effects at the hypothalamic and/or pituitary level.
D000328:Adult; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology; D011954:Receptors, Dopamine / Q000187:drug effects*; D012737:Sex Factors; D013972:Thyrotropin / Q000378:metabolism*
D011954:Receptors, Dopamine; D013972:Thyrotropin; D008787:Metoclopramide