title: [Interferon-inducing and antiviral activity of levamisole].
abstract: It was shown that levamisol administered orally to mice induced production of interferon with its maximum level in 4-6 hours and prolonged subsequent circulation in the host (the observation period of 5 days). Antiviral activity of levamisol in experimental forest-spring encephalitis was shown (protection of 35-40 per cent). When levamisol were used in combination with polyguacyl, an additive effect was recorded.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004666:Encephalitis Virus, Venezuelan Equine / Q000187:drug effects; D004669:Encephalitis Viruses, Tick-Borne / Q000187:drug effects; D007369:Interferon Inducers; D007978:Levamisole / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D051379:Mice; D009975:Orthomyxoviridae / Q000187:drug effects; D011066:Poly C / Q000494:pharmacology; D011068:Poly G / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D007369:Interferon Inducers; D011068:Poly G; C008961:poly G-poly C; D007978:Levamisole; D011066:Poly C
vernacular_title: Interferonindutsiruiushchaia i protivovirusnaia aktivnost' levamizola.