Differential effects of enkephalin within hippocampal areas.
The synthetic opiate D-Alanine-methionine enkephalin (D-Ala) affects neuronal activity of the fascia dentata (FD). D-Ala causes a depression of the population spike evoked by stimulation of the perforant path, which is antagonized by naloxone. In so called "Tandem" experiments it was shown that D-Ala had opposite effects on the CA1 pyramidal and FD granule cells. It is likely that in the FD the site of action of D-Ala is at the afferent synapses.
D000818:Animals; D001640:Bicuculline / Q000031:analogs & derivatives / Q000494:pharmacology; D004723:Endorphins / Q000494:pharmacology*; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives*; D004745:Enkephalins / Q000494:pharmacology*; D006168:Guinea Pigs; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D009270:Naloxone / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D051381:Rats
D004723:Endorphins; D004745:Enkephalins; D009270:Naloxone; C017069:bicuculline methiodide; D004744:Enkephalin, Methionine; C013801:enkephalin-Met, Ala(2)-; D001640:Bicuculline