[Effect of cooling on rhythmo-inotropic relations in pathologically altered myocardium].
Fragments of the right atrium auricle from patients with congenital and acquired heart diseases were used to study the effect of the Tyrode solution temperature over the 60-minute cessation of electrical stimulation of the preparations on the recovery of the amplitude of rhythmic contractions after the pause. The lack of stimulation within 34 to 24 degrees C does not lower the contraction amplitude after warming of the preparations and renewal of rhythmic stimulation. The hypothermal pause at a temperature of 10-14 degrees C leads to the development of contractures and suppresses the myocardial contractility. The positive inotropic action of dopamin (1.10(-6) g/ml), isadrin (1.10(-7) g/ml) and strophanthine (1.10(-6) g/ml) on the myocardium in patients with acquired heart diseases is remarkably diminished after the hypothermal pause.
D003080:Cold Temperature; D004298:Dopamine; D006321:Heart / Q000503:physiopathology*; D006330:Heart Defects, Congenital / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D007545:Isoproterenol; D009200:Myocardial Contraction; D012214:Rheumatic Heart Disease / Q000503:physiopathology*; D013328:Strophanthins
D013328:Strophanthins; D007545:Isoproterenol; D004298:Dopamine
Vliianie okhlazhdeniia na ritmo-inotropnye otnosheniia v patologicheski izmenennom miokarde.