[Lipid spectrum characteristics of the myocardium of white rats in hypoxic hypoxia].
By a modified microthin-layer chromatography in the total lipid spectrum of the cardiac muscle of white rats exposed to acute oxygen deficiency in an altitude chamber was investigated. It was found that the content of total lipids, phospholipids, free cholesterol, free fatty acids and triglycerides decreased during acute hypoxia. The exposure induced changes in the amount of glycerophosphatids whose content diminished significantly. The concentration of phosphatidyl serines and phosphatidyl ethanol amines lowered to a lesser extent while that of sphingomyelins increased. Acute oxygen deficiency accelerates the release of inorganic phosphate from the heart, thus, together with other factors, leading to disorders in the heart energetics. These findings indicate an important role of hypoxic hypoxia in the disturbances of lipid metabolism of the myocardium. This needs to be taken into consideration in the diagnostics and treatment of such states.
D000208:Acute Disease; D000818:Animals; D000860:Hypoxia / Q000378:metabolism*; D050356:Lipid Metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D010743:Phospholipids
Kharakteristika lipidnogo spektra serdechnoĭ myshtsy belykh krys pri gipoksicheskoĭ gipoksii.