HLA dependence of sensitivity to nickel and chromium.
A group of patients with cutaneous sensitivity was compared with another group with cement dermatitis who showed sensitivity to chromate. HLA typing for A and B locus antigens demonstrated a 29% incidence of B21 in the nickel sensitive group (control population 4.9%) and the antigen was not found in 16 patients with chromium sensitivity. It is suggested that this may represent a hapten specific HLA dependent immune response in man.
D002857:Chromium / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000209:etiology*; D005260:Female; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D006238:Haploidy; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D009532:Nickel / Q000009:adverse effects*; D010375:Pedigree
D006680:HLA Antigens; D002857:Chromium; D009532:Nickel