[Difficulties of early diagnosis of liver damage in persons exposed to vinyl chloride].
The authoress presents results of examinations of 228 vinyl chloride exposed workers. Considerable exposure is revealed by 5 cases of acroosteolysis and 45 cases of vascular disturbances in peripheral segments of extremities. The statistical analysis of numerical values of GPT, GOT, GGTP, AP, serum Che, bilirubin, prothrombin and proteinogram did not show any significant differences between the vinyl chloride exposed group and 70 controls. Of 50 persons in whom additionally BSP test and liver scintigram were performed and half-life of activity decrease was determined after intravenous administration of Bengal rose 131-J, 26 cases of moderate megalohepatia (scintigram) and 9 cases with positive BSP test were found. The half-life of 131-J elimination from blood lasted about 10-26 minutes and did not correlate with BSP test. The authoress draws attention to the lack of reliable and generally accessible methods of early diagnosis of hepatopathy in vinyl chloride exposed workers.
D000328:Adult; D000393:Air Pollutants / Q000009:adverse effects*; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000187:drug effects; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced*; D011877:Radionuclide Imaging; D012395:Rose Bengal; D013448:Sulfobromophthalein; D014752:Vinyl Chloride / Q000009:adverse effects*; D014753:Vinyl Compounds / Q000009:adverse effects*
D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D014753:Vinyl Compounds; D013448:Sulfobromophthalein; D012395:Rose Bengal; D014752:Vinyl Chloride
Trudności wczesnego rozpoznawania uszkodzenia watroby u osób narazonych na chlorek winylu.