Reversal of the normal pattern of renal choline metabolism during uremia in rats.
Chronic uremia was produced in rats by removal of 85% of renal mass. 3 and 8 weeks later in the remnant kidneys the normal ratio of phosphorylcholine/betaine production from 14C-choline (1:2) was reversed. Phosphorylcholine production rose from 24.0 +/- 1.4 to 45.6 +/- 4.5 pmol/min/mg protein (p less than 0.001), and betaine production fell from 51.0 +/- 1.4 to 23.1 +/- 4.5 pmol/min/mg protein (p less than 0.001). This reversed pattern is also found in fetal and neonatal kidneys and during renal compensatory growth.
D000818:Animals; D001622:Betaine / Q000096:biosynthesis; D002794:Choline / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism* / Q000502:physiology; D007676:Kidney Failure, Chronic / Q000378:metabolism; D009392:Nephrectomy; D010767:Phosphorylcholine / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014511:Uremia / Q000378:metabolism*
D010767:Phosphorylcholine; D001622:Betaine; D002794:Choline