Cerebral autoregulation: an in vitro study.
Cerebral autoregulation can be duplicated in vitro using the large middle cerebral arteries from a calf. The limits of autoregulation were between 50 and 150 mm Hg. Excessively high pressures may lead to the appearance of the "sausage- or bead-string" response followed by forced dilation. These results suggest the existence of an intrinsic myogenic mechanism responsive to intraluminal pressure changes.
D000818:Animals; D002417:Cattle; D002536:Cerebral Arteries / Q000502:physiology; D002560:Cerebrovascular Circulation; D006706:Homeostasis; D066298:In Vitro Techniques; D010477:Perfusion; D014661:Vasoconstriction; D014664:Vasodilation