Naloxone blocks the effect of diazepam and meprobamate on conflict behaviour in rats.
The effect of naloxone on the anticonflict action of diazepam was studied in a model involving foot shock-induced suppression of food-rewarded operant behaviour. Both 1 and 10 mg/kg naloxone SC abolished the increase in punished responding produced by diazepam and chlordiazepoxide. Naloxone also blocked the anticonflict effect of meprobamate. These observations are discussed in terms of a possible involvement of endogenous opioid peptides in the anxiolytic effects of tranquillizers.
D000818:Animals; D003220:Conflict, Psychological; D003975:Diazepam / Q000037:antagonists & inhibitors*; D005260:Female; D008620:Meprobamate / Q000037:antagonists & inhibitors*; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D009270:Naloxone; D008620:Meprobamate; D003975:Diazepam