The intravenous toxicity of lentinan to the beagle dog.
The i.v administration of lentinan to the Beagle dog induced changes in the cytoplasm of macrophagic cells in the liver, spleen, kidney, lungs, lymph nodes, small intestine. Electron-lucent or filamentous inclusions were demonstrated in the liver, kidney and spleen. A dose level of 0.5 mg/kg/day was without adverse effect.
D000818:Animals; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D004285:Dogs; D005260:Female; D007275:Injections, Intravenous; D007912:Lentinan / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011134:Polysaccharides / Q000633:toxicity*; D013997:Time Factors
D011134:Polysaccharides; D007912:Lentinan