Multiple conductance change associated with the slow excitatory potential in mammalian sympathetic neurons.
When the membrane potential was manually clamped, the non-cholinergic excitatory potential was associated with either a sustained increase, an initial decrease followed by a prolonged increase or no apparent change in neuronal input resistance. In the majority of neurons studied, the amplitude of non-cholinergic depolarization was augmented upon conditioning hyperpolarization, whereas it was attenuated in a low Na solution. The results are consistent with the suggestion that the non-cholinergic depolarization may be generated by a change of multiple conductances that may include GNa activation and GK inactivation.
D000320:Adrenergic Fibers / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation; D005724:Ganglia / Q000502:physiology; D006168:Guinea Pigs; D007001:Hypogastric Plexus; D008297:Male; D008564:Membrane Potentials; D008643:Mesentery / Q000294:innervation; D009431:Neural Conduction; D009474:Neurons / Q000502:physiology