[Etiologic study of the GABAergic mechanisms of diazepam tolerance].
Etiologic analysis used in experiments on isolated mice has shown that each biologically important category of intraspecies behavior (aggression, communicability, etc) is characterized by its own time course of diazepam tolerance. Participation of the GABAergic mechanisms in acute and chronic effects of diazepam was demonstrated to vary. Acute effect of diazepam was dominated by the sedative component whose action was reversed by picrotoxin and bicuculline that activated motor rather than zoosocial activities. In the course of diazepam tolerance induction, picrotoxin and bicuculline counteracted antiaggressive action of diazepam and diazepam-induced activation of intraspecies communicability. However, they did not fully inhibit the communicability.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001640:Bicuculline / Q000494:pharmacology; D003975:Diazepam / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004361:Drug Tolerance; D008297:Male; D051379:Mice; D010852:Picrotoxin / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D001640:Bicuculline; D003975:Diazepam; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid
Etiologicheskoe izuchenie GAMK-ergicheskikh mekhanizmov tolerantnosti k diazepamu.