[Effect of thyroxine on the NADH cytochrome c reductase activity of microsomes and outer mitochondrial membrane of rat liver depending on age].
The rotenone-insensitive NADH-cytochrome c reductase activity and cytochrome b5 content in mitochondria and microsomes of liver of 1-, 3-, 12- and 24-month-old rats were studied. Thyroxine injection caused a considerable decrease in the microsomal activity in all age groups under study; in mitochondria this effect was increased with age. The decrease of the cytochrome b5 content was maximal in the microsomes and mitochondria of 12- and 24-month-old animals and was insignificant in 1-month-old rats. It was assumed that the age variations in regulation of the outer mitochondrial membrane function can be due changes in their population.
D000375:Aging; D000818:Animals; D003579:Cytochrome Reductases / Q000378:metabolism*; D003580:Cytochromes / Q000378:metabolism; D015786:Cytochromes b5; D007425:Intracellular Membranes / Q000201:enzymology*; D007700:Kinetics; D008099:Liver / Q000254:growth & development*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000201:enzymology*; D009245:NADH Dehydrogenase / Q000378:metabolism*; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology*
D003580:Cytochromes; D015786:Cytochromes b5; D003579:Cytochrome Reductases; D009245:NADH Dehydrogenase; D013974:Thyroxine
Vliianie tiroksina na NADH-tsitokhrom-c-reduktaznuiu aktivnost' mikrosom i naruzhnoĭ mebrany mitokhondriĭ pecheni krys raznogo vozrasta.