title: The efficacy of anthelmintics against Thysaniezia giardi in South Africa.
abstract: Two field cases of apparent inefficacy of albendazole against cestodes in lambs were investigated. In both farms Thysaniezia giardi was identified and 2 critical controlled trials were conducted to determine the efficacy of 5 anthelmintics against T. giardi. Albendazole dosed at 3,8 mg/kg or 7,6 mg/kg live mass, mebendazole at 15 mg/kg were totally ineffective against T. giardi. Treatment with resorantel at 65 mg/kg or niclosamide at 50 mg/kg however, caused expulsion of the strobilae within 16--24 hours after treatment and at autopsy, lambs were free of scoleces of T. giardi.
mesh_terms: D015766:Albendazole; D000813:Anilides / Q000008:administration & dosage; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage*; D001562:Benzimidazoles / Q000008:administration & dosage; D002159:Cambendazole / Q000008:administration & dosage; D008463:Mebendazole / Q000008:administration & dosage; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D009534:Niclosamide / Q000008:administration & dosage; D012118:Resorcinols / Q000008:administration & dosage; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*
chemical_list: D000813:Anilides; D000871:Anthelmintics; D001562:Benzimidazoles; D012118:Resorcinols; D002159:Cambendazole; C000982:resorantel; D008463:Mebendazole; D009534:Niclosamide; D015766:Albendazole