The hepatotoxicity of thiobenzamide-S-oxide.
Administration of thiobenzamide (TB) (0.18 mmol/100 g b.w.) to rats caused the appearance in serum and urine of a compound identified as thiobenzamide-S-oxide. When synthesized and given by oral administration, this compound induced the early appearance of liver centrilobular necrosis, impairment of glucose-6-phosphatase and aminopyrine demethylase activities, and diminished cytochrome P-450 content. Liver necrosis was suppressed by the prior administration of 20-methylcholanthrene. It is concluded that TB-S-oxide is involved, possibly as a proximate precursor, in TB-induced liver damage.
D000577:Amides / Q000378:metabolism* / Q000633:toxicity*; D000818:Animals; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009336:Necrosis; D051381:Rats; D013854:Thioamides / Q000378:metabolism* / Q000633:toxicity*
D000577:Amides; D013854:Thioamides; C032187:thiobenzamide-S-oxide; C015539:thiobenzamide