Urinary metabolites of N-nitrosodipropylamine, N-nitroso-2-hydroxypropylpropylamine and N-nitroso-2-oxopropylpropylamine in the rat.
Analysis of 24 h urine samples of rats administered N-nitrosodipropylamine (NDPA), N-nitroso-2-hydroxypropylpropylamine (NHPPA) or N-nitroso-2-oxopropylpropylamine (NOPPA) showed that the major excretion product in each case was the beta-glucuronide of NHPPA. This conjugate was shown to be present at levels of about 5%, 80% and 50% of the administered dose for NDPA, NHPPA and NOPPA, respectively, based on exhaustive hydrolysis of the urine samples with beta-glucuronidase. Generally only low levels (less than 2%) of the unchanged nitrosamines or their unconjugated metabolites (NHPPA for administered NDPA and NHPPA for administered NOPPA) were detected. We were unable to detect N-nitrosomethylpropylamine or N-nitrosodimethylamine in the urine of any of the animals.
D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000652:urine*; D006868:Hydrolysis; D008297:Male; D009602:Nitrosamines / Q000652:urine*; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; D009602:Nitrosamines; C013161:N-nitroso(di-n-propyl)amine; C016509:2-hydroxypropyl-n-propylnitrosamine; C013622:nitrosobis(2-oxopropyl)amine