title: Effect of intrauterine administration of antiprostaglandin drugs on implantation in the rat.
abstract: Three antiprostaglandin drugs, acetylsalicylic acid, indomethacin and ibuprofen, were administered intraluminally at different does to pregnant rats on Day 4 of pregnancy. It was observed that ibuprofen administered at a dose of 400 micrograms inhibited implantation in all rats. Ibuprofen when administered at a lower dose of 100 or 200 micrograms on Day 4 of pregnancy or at a dose of 400 micrograms on Day 3 or 5 of pregnancy did not exert such an antiimplantation effect. Acetylsalicylic acid and indomethacin also induced, but to a lesser extent, an antiimplantation effect when administered at a dose of 400 micrograms on Day 4 of pregnancy.
mesh_terms: D000818:Animals; D001241:Aspirin / Q000008:administration & dosage; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D007052:Ibuprofen / Q000008:administration & dosage; D007213:Indomethacin / Q000008:administration & dosage; D007267:Injections; D011247:Pregnancy; D011448:Prostaglandin Antagonists / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D013997:Time Factors; D014599:Uterus
chemical_list: D011448:Prostaglandin Antagonists; D001241:Aspirin; D007052:Ibuprofen; D007213:Indomethacin