title: Induction of experimental autoimmune diabetes by low-dose streptozotocin treatment in genetically resistant mice.
abstract: We have studied the effect of suppressor cell elimination on the induction of experimental autoimmune diabetes in mouse strains which are normally low or intermediate responders to multiple low-dose streptozotocin treatment. BALB/c (low responder) and C57BL/6J (intermediate responder) mice received 70 mg cyclophosphamide/kg, 1 or 6 days before the onset of streptozotocin injections. Following cyclophosphamide treatment, BALB/c mice become susceptible to the diabetogenic effect of streptozotocin. Similarly the manifestation of diabetes in C57BL/6J mice is enhanced. Thus in both strains immunomodulation by cyclophosphamide treatment significantly increases the susceptibility towards the diabetogenic effect of streptozotocin. We therefore conclude that in mice of strains BALB/c and C57Bl/6J suppressor cells control the level of resistance towards the induction of experimental autoimmune diabetes by low-dose streptozotocin treatment.
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology*; D001786:Blood Glucose; D003520:Cyclophosphamide / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000209:etiology*; D004305:Dose-Response Relationship, Drug; D006943:Hyperglycemia / Q000209:etiology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics*; D008810:Mice, Inbred C57BL / Q000235:genetics*
chemical_list: D001786:Blood Glucose; D003520:Cyclophosphamide