Screening system for the evaluation of preparations with potential cytostatic and immunotropic activity. III. Derivatives of hexahydrochromate.
Activity of a group of hexahydrochromate derivatives was evaluated as compared to the mitogenic activity of phytohemagglutinin. The tested compounds displayed only slight activity although chromate derivatives are known for their antiinflammatory and anti-allergic effect. It was known that affinity to nucleic acids is indispensable for the induction of cytostatic effect of the preparations and not necessary while inducing antiinflammatory and antiallergic effect.
D000970:Antineoplastic Agents / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D002840:Chromates / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*
D000970:Antineoplastic Agents; D002840:Chromates; D007166:Immunosuppressive Agents