Pharmacological evidence of supersensitivity of central serotonergic receptors involved in the control of prolactin secretion.
m-Chlorophenylpiperazine (m-CPP), a serotonin receptor agonist, induced dose-related increase in plasma prolactin levels in the rat. This effect was significantly prevented by pretreatment with metergoline, a serotonin receptor blocker. Long-term degeneration of hypothalamic serotonin nerve endings induced by intraventricular injection of 5, 7-dihydroxytryptamine, significantly enhanced the PRL-releasing action of m-CPP, as revealed by the shift to the left in the dose-response curve that relates the dose of m-CPP to plasma PRL levels. Thus the evidence suggests the possible development of supersensitivity of central serotonin receptors involved in the control of prolactin release.
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology*; D000818:Animals; D004102:Dihydroxytryptamines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood / Q000378:metabolism; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*
D004102:Dihydroxytryptamines; D010879:Piperazines; D011985:Receptors, Serotonin; D015116:5,7-Dihydroxytryptamine; D011388:Prolactin; C015068:1-(3-chlorophenyl)piperazine