[Comparative characteristics of the activity of lysosomal proteinases in in transplantable cell cultures susceptible and resistant to a specific group of viruses].
Institute of Nutrition, Academy of Medical Sciences of the USSR, Moscow Directed change of the genotype in cell cultures (Hela, fibroblasts, L929), which leads to the resistance to challenge with some of the viruses is accompanied by pronounced modulation of the activity of lysosomal proteinases, cathepsins A, B1, D and, in the first turn, by a considerable reduction (by 2--12 times) of cathepsin C activity. The data obtained indicate an important role of the proteolytic system of the cell lysosomal apparatus in providing defence reactions.
D000818:Animals; D002403:Cathepsins / Q000502:physiology*; D002478:Cells, Cultured; D004198:Disease Susceptibility; D005347:Fibroblasts; D006367:HeLa Cells; D006801:Humans; D007739:L Cells; D008247:Lysosomes / Q000201:enzymology*; D051379:Mice; D014777:Virus Diseases / Q000201:enzymology / Q000276:immunology*
D002403:Cathepsins
Sravnitel'naia kharakteristika aktivnosti lizosomal'nykh proteinaz v perevivaemykh kletochnykh kul-turakh, vospriimchivykh i rezistentnykh k opredelennoĭ gruppe virusov.