Acute toxicity of organic solvents, heavy metals and DDT tested in cultures of mouse neuroblastoma cells.
To test the toxicity of some substances, known to affect the nervous system i.e. organic solvents, heavy metals and DDT, their ability to cause cell detachment of cultured mouse neuroblastoma cells was investigated. A TD25 value was obtained by graphic estimation of the concentration needed to cause 25% of the total cell number to detach. These TD25 values were compared with LD50 values obtained from the literature and a correlation was found.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003634:DDT / Q000633:toxicity*; D008670:Metals / Q000633:toxicity*; D008767:Methylmercury Compounds / Q000633:toxicity; D051379:Mice; D009374:Neoplasms, Experimental; D009447:Neuroblastoma; D012997:Solvents / Q000633:toxicity*
D008670:Metals; D008767:Methylmercury Compounds; D012997:Solvents; D003634:DDT; C004925:methylmercuric chloride