Strain differences in resistance to infection reversed by route of challenge: studies in blastomycosis.
The inbred mouse strains C3H/HeJ and DBA/1J have been shown to represent the extremes of susceptibility and resistance, respectively, to pulmonary blastomycosis. This pattern was completely reversed when challenge was performed by the intraperitoneal route, whether a virulent or an attenuated strain of Blastomyces dermatitidis was utilized. By a third route (subcutaneous), the differences were insignificant. Inhibition of replication of blastomyces in vitro by macrophages from both strains, before or after activation by subcutaneous infection, was similar.
D000818:Animals; D001758:Blastomyces / Q000254:growth & development; D001759:Blastomycosis / Q000235:genetics / Q000276:immunology*; D007113:Immunity, Innate; D008172:Lung Diseases, Fungal / Q000276:immunology*; D008264:Macrophages / Q000502:physiology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA; D009666:Nose; D010529:Peritoneal Cavity; D012867:Skin