Blood levels of middle molecules and their effects on motor nerve conduction velocity.
This paper presents the data from 53 patients with end stage renal disease and under regular dialysis treatment. The haemodialysis scheme consists fundamentally in short dialysis with coil dialyzers. The correlations between motor nerve conduction velocity and the patients' residual renal function, HD dose, and serum level of middle molecules are analyzed. At the same time, the influence of RRF and HH dose on the serum level of MM is studied. From the assembled data, several deductions can be established: Uremic neuropathy is fundamentally influenced by the MM and the RRF; the HD dose also exerts some influence on the MNCV, but to a much lesser degree and through dialysables substances different from the MM; the influence of RRF on the MNCV is mainly due to the modification induced by this variable in the serum level of MM.
D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D009046:Motor Neurons / Q000502:physiology*; D009422:Nervous System Diseases / Q000209:etiology / Q000503:physiopathology*; D009431:Neural Conduction; D006435:Renal Dialysis; D014118:Toxins, Biological / Q000097:blood*; D014511:Uremia / Q000503:physiopathology* / Q000628:therapy
D014118:Toxins, Biological; C026865:uremia middle molecule toxins