title: Treatment of angina pectoris with propranolol: the harmful effects of cigarette smoking.
abstract: The effects of smoking on the treatment of angina has been studied in 10 patients. Each patient underwent 4 randomized 1-week treatments consisting of on and off smoking, and on and off propranolol (360 mg/day). At the end of each treatment a maximal exercise test was performed using 16 praecordial leads. Smoking was associated with a significantly higher heart rate, blood pressure, area and severity of ST-segment depression. This was not abolished by propranolol. Thus, smoking aggravates the simple haemodynamic variables used to assess myocardial oxygen requirements and the electrocardiographic signs of ischaemia; this is true even after treatment with propranolol.
mesh_terms: D000787:Angina Pectoris / Q000188:drug therapy*; D001794:Blood Pressure; D003327:Coronary Disease / Q000503:physiopathology*; D004562:Electrocardiography; D005080:Exercise Test; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use*; D011897:Random Allocation; D012907:Smoking
chemical_list: D011433:Propranolol