[Effect of aminton on noradrenaline and adrenaline depots in the rat heart].
The authors examined the effect of the new Bulgarian antihypotensive prepavation aminton (2-amino-4-methyl pyridine) on the noradrenaline and adrenaline depots in the heart of rats. They found that aminton liberated considerable amounts o- the examined monoamines. This liberation was time and dose dependent. After a week treatment of the animals with small doses of aminton there were no significant changes in the rate of biosynthesis of noradrenaline in the heart. The analysis of catecholamine-liberating effect of aminton showed that this substance liberated noradrenaline by mechanisms, different from those participating in the reserpine effect. On the background of reserpine and atropine, aminton liberated noradrenaline in the heart of a rat, while hexametonium, tolazoline and johimbin inhibited such activity. The authors suggest that catecholamine-liberating effect of aminton is a substantial moment in realization of the manifested antihypotensive action of this substance.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000378:metabolism*; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D010847:Picolines / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D000959:Antihypertensive Agents; D010847:Picolines; C015672:2-amino-4-picoline; D009638:Norepinephrine; D004837:Epinephrine
Vliianie na amintona vŭrkhu depata na noradrenalin i adrenalin v sŭrtse na plŭkh.