Screening system for the evaluation of preparations with potential cytostatic and immunotropic activity. II. Derivatives of propionic and hydroxybutyric acids and of tetrahydrofuranone-2.
New screening system was used for the evaluation of preparations wih potential anti-mitotic, cytostatic and secondarily, immunodepressive activity. A group of compounds, derivatives of propionic and hydroxybutyric acids and of tetrahydrofuranone-2 was analyzed. It was showed that among them there were preparations reducing 14C-thymidine incorporation to lymphocyte nuclei. The authors pointed to the fact that in this mechanism, beside specific component, nonspecific component takes part, which results from the change of pH of the medium by the solutions of the investigated preparations. Relation between chemical structure and pharmacological activity in this group of compounds is discussed.
D000970:Antineoplastic Agents / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D005663:Furans / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006885:Hydroxybutyrates / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D011422:Propionates / Q000494:pharmacology*
D000970:Antineoplastic Agents; D005663:Furans; D006885:Hydroxybutyrates; D007166:Immunosuppressive Agents; D011422:Propionates