Evaluation of effect of drugs on the exercise ECG.
The result of an exercise ECG can be represented on an XY chart by four monovariate (normal) distributions: heart rate (divided by X axis); blood pressure (divided by Y axis); Working time deficit (-X axis); ST depression (-Y axis); and two bivariate (elliptic) distributions: double product (divided by X divided by Y quadrant); ST X time-deficit index (-X -Y quadrant). Charts for 100 normal men, 100 normal women, 100 coronary men, and 100 coronary women were first of all built up. Charts of 100 patients under propanolol, 33 under atenolol, 47 under nidefipine, 13 under verapamil, and 44 under isosorbide dinitrate were then compared with those from coronary men. Beta blockers produced a shift in all six parameters; nifedipine modified blood pressure, double product, ST and time deficit; verapamil only changed blood pressure and time deficit; isosorbide changed ST, time deficit and the ST X time-deficit index.
D001262:Atenolol / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002317:Cardiovascular Agents / Q000494:pharmacology*; D003327:Coronary Disease / Q000503:physiopathology; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007548:Isosorbide Dinitrate / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D002317:Cardiovascular Agents; D001262:Atenolol; D011433:Propranolol; D014700:Verapamil; D009543:Nifedipine; D007548:Isosorbide Dinitrate