In vitro catabolism of human very low density lipoproteins: fate of apoproteins B and C.
The fate of apo C-II, apo C-III and apo B during the in vitro catabolism of human very low density lipoproteins (VLDL) by the action of purified lipoprotein lipase was studied. Up to 58 percent of triglyceride apo C-II and C-III was released from VLDL during hydrolysis and at a similar rate. The amount of C apoproteins lost was proportional to triglyceride hydrolysis. The apo B content of VLDL remained constant. From these studies we conclude that during the hydrolysis of human VLDL, lipoprotein lipase, while including a net loss of apo C, is not responsible for major changes in the apo C-II/C-III ratio.
D053304:Apolipoprotein C-II; D053305:Apolipoprotein C-III; D001053:Apolipoproteins / Q000378:metabolism*; D001055:Apolipoproteins B; D001056:Apolipoproteins C; D006801:Humans; D066298:In Vitro Techniques; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism
D053304:Apolipoprotein C-II; D053305:Apolipoprotein C-III; D001053:Apolipoproteins; D001055:Apolipoproteins B; D001056:Apolipoproteins C; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D008071:Lipoprotein Lipase