[Variations in parathormone serum levels during treatment of Paget's disease with calcitonin of human or salmon origin (author's transl)].
Biological effects of increasing doses of human and salmon calcitonin (CT) have been studied in 17 patients suffering from Paget's disease of bone. Results show a dose response relationship on indirect indices of bone turn-over. The plateau phenomenon occurs with both CT and more rapidly with the lower dosage. There is also a transient increase in parathyroid activity during the period of time when bone turn-over is decreasing. Calciuretic effect was more pronounced with salmon than with human CT.
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002116:Calcitonin / Q000008:administration & dosage / Q000627:therapeutic use*; D002118:Calcium / Q000652:urine; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D010001:Osteitis Deformans / Q000188:drug therapy* / Q000378:metabolism; D010281:Parathyroid Hormone / Q000097:blood*; D012474:Salmon
D010281:Parathyroid Hormone; D002116:Calcitonin; D000469:Alkaline Phosphatase; D002118:Calcium
Variations des taux sériques de parathormone au cours du traitement de la maladie de Paget par calcitonine humaine ou de saumon.