title: Bicarbonate and the trans-endothelial short circuit current of human cornea.
abstract: Experiments were performed in vitro, to determine the effect of bicarbonate ion concentration on human cornea endothelial potential difference, short circuit current and resistance. Decreasing the bicarbonate concentration resulted in a reversible and parallel fall in potential differences and short circuit current, whereas resistance remained unchanged. The results demonstrate that bicarbonate is a necessary component of the mechanisms that generate trans-endothelial short circuit current. Similarities between data derived from rabbit, ox and human suggest that a common underlying bicarbonate dependent mechanism is operating in these species.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000293:Adolescent; D001639:Bicarbonates / Q000494:pharmacology*; D003315:Cornea / Q000187:drug effects*; D004594:Electrophysiology; D004727:Endothelium / Q000187:drug effects; D006801:Humans
chemical_list: D001639:Bicarbonates