title: Comparison of three methods for determination of sulfamethazine in swine tissues: collaborative study.
abstract: An interlaboratory study of 3 methods for the determination of sulfamethazine in swine muscle and liver tissue was conducted. A gas chromatographic (CG), a combined gas chromatographic-mass spectrometric (GC/MS), and a colorimetric method were evaluated. Four fortified and 2 incurred levels of sulfamethazine ranging from 0.00 to 0.45 ppm were studied. The study revealed that the GC/MS procedure provides the most reliable data and that the GC method provides acceptable data with the incorporation of appropriate controls. The recoveries for the GC/MS method typically ranged from 90 to 100% for swine liver and muscle. The GC and GC/MS methods have been adopted official first action.
mesh_terms: D000818:Animals; D002849:Chromatography, Gas / Q000379:methods; D003124:Colorimetry / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D008099:Liver / Q000032:analysis; D008460:Meat / Q000032:analysis*; D009132:Muscles / Q000032:analysis; D013418:Sulfamethazine / Q000032:analysis*; D013552:Swine
chemical_list: D013418:Sulfamethazine