Interaction of bovine serum albumin with PGBx (polymeric 15-keto-prostaglandin B1).
Bovine serum albumin (BSA) interacts with PGBx, a polymeric derivative of 15-keto-prostaglandin B1, to form a complex that does not exhibit the fluorescence of free BSA. The complex is soluble at pH 5.2 in contrast to free PGBx, which is insoluble. Molar ratio of the BSA-PGBx complex is 1:18. This complexing appears to suppress the ability shown by non-complexed PGBx to reactivate phosphorylation in degraded isolated rat liver mitochondria.
D000818:Animals; D002417:Cattle; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D011108:Polymers; D011453:Prostaglandins; D011456:Prostaglandins B; D011485:Protein Binding; D051381:Rats; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013050:Spectrometry, Fluorescence
D011108:Polymers; D011453:Prostaglandins; D011456:Prostaglandins B; D012710:Serum Albumin, Bovine; C024303:prostaglandin Bx