[Binding of 3H-serotonin, 3H-diazepam and lipid peroxidation in brain membranes].
It was demonstrated that the processes of lipid peroxidation in brain tissues of rats induced by hyperoxia and Fe-ascorbate system in vivo and in vitro significantly influence specific binding of serotonin and diazepam. Lipid peroxidation caused various changes in the ability to bind utilized ligands: 3H-serotonin binding decreased by 53%, while that of 3H-diazepam increased by 30%. Preliminary administration of the synthetic antioxidant 4-methyl-2,6-ditretbutylphenol prevented these changes.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D003975:Diazepam / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000378:metabolism*
D000975:Antioxidants; D008054:Lipid Peroxides; D002084:Butylated Hydroxytoluene; D012701:Serotonin; D003975:Diazepam
Sviazyvanie 3H-serotonina, 3H-diazepama i perekisnoe okislenie lipidov v membranakh mozga.