The influence of sex hormones on rat platelet sensitivity to adenosine-diphosphate.
The sensitivity of rat platelets to the aggregating agent adenosine-diphosphate (ADP) was studied. Platelets form male and female rats demonstrated comparable sensitivity. Neither ovariectomy nor castration altered platelet sensitivity to ADP. However platelets form mock-operated female, but not mock-operated male rats were less sensitive. Administration of physiological doses of 17 beta-oestradiol to ovariectomised rats reduced platelet sensitivity. Administration of 17 beta-oestradiol to mock operated female rats increased platelet sensitivity to ADP. The results suggest that physiological amounts of oestrogen induce a loss of platelet sensitivity following surgery or stress, whereas higher concentrations of oestrogens increase platelet sensitivity.
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D002369:Castration; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D004958:Estradiol; D000244:Adenosine Diphosphate; C010452:estradiol-17 beta-benzoate