Mitotic rate of rat thyroid follicular cells in vivo in response to a single injection of thyrotropin (TSH).
The mitotic rate of thyroid follicular cells was assessed by a stathmokinetic method at intervals from 15 min to 24 hr after a single injection of 1 iu/kg of thyrotropin (TSH). The mitotic rate was increased 15 min after TSH and remained elevated for 3 hr. Two further peaks of mitotic activity were present at 9 hr and 24 hr after TSH. Serum TSH concentrations were increased from 5 min to 3 hr with a maximum at 1 hr.
D000818:Animals; D007700:Kinetics; D008297:Male; D008938:Mitosis / Q000187:drug effects; D051381:Rats; D013961:Thyroid Gland / Q000166:cytology*; D013972:Thyrotropin / Q000097:blood / Q000494:pharmacology*
D013972:Thyrotropin