[Efficiency of ubiquinone and p-oxybenzoic acid in prevention of E-hypovitaminosis-induced development of muscular dystrophy].
It is shown that E-hypovitaminosis-induced muscular dystrophy in rabbits is accompanied by a sharp decrease in the body mass, an increase in the urine creatine-index, a decrease in the vitamin E and ubiquinone contents in the liver and skeletal muscle tissues. In the myocardium mitochondria a decrease in the vitamin E content and an increase in the ubiquinone content are observed. The activity of NADH-cytochrome c-, NADH-ubiquinone- and succinate-ubiquinone-reductase also varies in mitochondria of the studied tissues. In myocardium organellas a direct dependence is found between the content of ubiquinone, NADH- and succinate-ubiquinone-reductase activity and an inverse one-between its content and the activity of the NADH-cytochrome c-reductase system. It is established that p-oxybenzoic acid as well as vitamin E prevents development of muscular dystrophy and causes changes analogous in direction in the activity of the ubiquinone-dependent enzymic systems of mitochondria. Ubiquinone-9 is less efficient in preventing the development of muscular dystrophy.
D000818:Animals; D008099:Liver / Q000378:metabolism; D008930:Mitochondria, Liver / Q000201:enzymology; D008931:Mitochondria, Muscle / Q000201:enzymology; D009132:Muscles / Q000378:metabolism; D009137:Muscular Dystrophy, Animal / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D010226:Parabens / Q000627:therapeutic use*; D011817:Rabbits; D014451:Ubiquinone / Q000378:metabolism / Q000627:therapeutic use*; D014810:Vitamin E / Q000378:metabolism; D014811:Vitamin E Deficiency / Q000150:complications*
D010226:Parabens; D014451:Ubiquinone; D014810:Vitamin E; D009247:NADH, NADPH Oxidoreductases
Izuchenie éffektivnosti ubikhinona i p-oksibenzoĭnoĭ kisloty v preduprezhdenii razvitiia myshechnoĭ distrofii, vyzvannoĭ E-gipovitaminozom.