[On the testing of analgetically active substances (author's transl)].
Four standard analgetics were tested using the tail-flick and the hot-plate method, and by means of the Writhing syndrome. The frequency distributions of the data obtained from the control group were recorded first. The skewed distributions of the data yielded by the tail-flick and the hot-plate method were transformed into normal distributions. These normal distributions of data obtained form larger samples of control animals by the tail-flick and the hot-plate method permitted to develop alternative procedures of evaluation which led to dose-effect curves allowing to determine whether or not the effects of any single doses of the substances under study are significantly different. Testing the analgetics by means of the Writhing syndrome also yielded statistically interpretable dose-effect curves which resulted from a comparison with the frequency distributions of the data from control animals, all-or-not solutions being avoided. The evaluation procedures presented in this paper have the advantage that, in any case, the dose-related effects may be statistically interpreted due to the greater slopes of the dose-effect curves. Furthermore, these procedures improve the reproducibility of the dose-effect curves.
D000700:Analgesics; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D051379:Mice; D011930:Reaction Time / Q000187:drug effects
D000700:Analgesics
Zur Prüfung analgetisch wirksamer Substanzen.