Propranolol in the surgical treatment of hyperthyroidism, including severely thyrotoxic patients.
The perioperative course of 44 hyperthyroid patients prepared for surgery with propranolol alone, including 11 with severe thyrotoxicosis was compared to that of 20 euthyroid patients prepared for surgery with carbimazole. Conventional propranolol at a dosage of 160 mg/day was frequently insufficient to produce a high degree of beta-adrenergic blockade, particularly in severely thyrotoxic patients. A greater than 25 per cent reduction in sitting pulse rate was associated with a high degree of beta-blockade. The clinical course of patients with mild or moderate thyrotoxicosis was similar to that of the patients prepared with carbimazole. In contrast, the course of severely thyrotoxic patients  was complicated and, in addition to a higher preoperative propranolol dosage, these patients commonly required supplemental propranolol after operation. Although thyroid crisis did not occur in any patient, we cannot recommend the use of propranolol alone for the severely thyrotoxic patient.
D000328:Adult; D002231:Carbimazole / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D006980:Hyperthyroidism / Q000503:physiopathology / Q000601:surgery*; D011292:Premedication; D011433:Propranolol / Q000627:therapeutic use*; D011674:Pulse / Q000187:drug effects; D013965:Thyroidectomy
D002231:Carbimazole; D011433:Propranolol