[Biochemical changes in vinyl chloride poisoning. I. Effect of different conditions of vinyl chloride exposure on lipid metabolism in rats].
Lipids metabolism was evaluated in rats chronically exposed to vinyl chloride concentrations of 50, 500 and 20 000 ppm. The studies involved: 1) estimation of lipids content in serum; 2) estimation of cholesterol and triglycerides content in some tissues (liver, muscles, connective tissue, aortic wall), 3) evaluation of the rate of incorporating 14C-acetate into 14C-cholesterol in liver and the rate of its transition into blood. The studies were carried out after 1, 3, 6 and 10 months of vinyl chloride exposure. The results prove that under effects of vinyl chloride exposure some tendencies of an increase in the total and esterified cholesterol in serum vary with the magnitude of exposure (vinyl chloride airborne concentration, intoxication time). As to triglycerides and phospholipids at the final phase of intoxication (after 10 months) a significant increase in their serum content is found at the 20 000 ppm. concentration, whereas there are no changes in the free fatty acids level. As to the examined tissue only in liver some tendencies are found of a decrease in cholesterol content and much greater decrease in triglycerides level, which is progressing with intoxication time and exposure magnitude. No effect of vinyl chloride on the level of lipids in muscles, aortic wall and connective tissue were found. Studies of cholesterol synthesis in liver showed some increase in the rate of building 14C-acetate into cholesterol only in two highest vinyl chloride concentrations (500 and 20 000 ppm) after 10 months of exposure. The results demonstrate that chronic vinyl chloride exposure only slightly affects lipid metabolism. The most significant changes occur only after 10 months of exposure at the concentration of 20 000 ppm. It is supposed that the disturbances in lipid metabolism have no important contribution to vinyl chloride poisonings pathology.
D000818:Animals; D001011:Aorta / Q000378:metabolism; D003238:Connective Tissue / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014752:Vinyl Chloride / Q000008:administration & dosage / Q000506:poisoning*; D014753:Vinyl Compounds / Q000506:poisoning*
D014753:Vinyl Compounds; D014752:Vinyl Chloride
Zmiany biochemiczne w zatruciach chlorku winylu. I. Wpływ róznych warunków ekspozycji na chlorek winylu na przemiane lipidowa u szczurów.