title: Phencyclidine and behavior: I. Sensory-motor function, activity level, taste aversion and water intake.
abstract: Phencyclidine (PCP) injections in rats at doses of 4 mg/kh increased activity level, which might have been a function of impaired habituation. At doses of 8 mg/kg PCP produced a marked reduction in activity level. At doses of 12 mg/kg and above there were profound disruptive effects in detection of odors, visual square and touch measures, and performance of placing reflexes requiring visuo-motor coordination, righting, grasping reflexes, and equilibrium. Decreases in water intake occurred only at higher dose levels of PCP (16 and 24 mg/kg). On a qualitative basis the changes observed in rats are similar to changes described for humans.
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D004327:Drinking Behavior / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009048:Motor Skills / Q000187:drug effects; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D012677:Sensation / Q000187:drug effects; D013649:Taste / Q000187:drug effects
chemical_list: D010622:Phencyclidine