Dopamine beta-hydroxylase inhibition in a patient with Wilson's disease and manic symptoms.
The authors studied the effect of dopamine beta-hydroxylase inhibition on the manic symptoms of a 34-year-old man. They found that fusaric acid decreased the patient's manic symptoms and that his symptoms approximately reverted to their previous state when a placebo was reinstituted.
D000328:Adult; D000341:Affective Disorders, Psychotic / Q000201:enzymology*; D001714:Bipolar Disorder / Q000188:drug therapy / Q000201:enzymology*; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors*; D005669:Fusaric Acid / Q000627:therapeutic use; D006527:Hepatolenticular Degeneration / Q000201:enzymology*; D006801:Humans; D008297:Male
D004299:Dopamine beta-Hydroxylase; D005669:Fusaric Acid