[Comparison of various empirical dosage suggestions for etomidate infusions on the basis of pharmacokinetic data (author's transl)].
The superposition principle of linear pharmacokinetics allows in a simple way simulation of blood levels and amounts of drug in other compartments for arbitrary dosage schemes provided the pharmacokinetic data are known. Assuming a 2-compartment model we compare for etomidate different dosage schemes as described in the literature with respect to the resulting course of blood levels or amounts of drug in different compartments. In conjunction with the reported clinical observations one can estimate minimal therapeutic blood levels and identify the compartment to which the site of action may be associated.
D000771:Anesthesia, Intravenous; D003201:Computers; D004305:Dose-Response Relationship, Drug; D005045:Etomidate / Q000008:administration & dosage* / Q000097:blood; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage*; D007700:Kinetics
D007093:Imidazoles; D005045:Etomidate
Vergleich verschiedener empirischer Dosierungsvorschläge für Etomidat-Infusionen anhand pharmakokinetischer Berechnungen.