[Lithium elimination by the isolated perfused rat kidney (author's transl)].
The pharmacokinetics of lithium, a drug with a narrow therapeutic index, depends on the renal elimination of the metal. An open circuit, constant flow isolated rat kidney preparation perfused with gelatinized (Haemaccel) Krebs-solution, was used to study the urinary elimination of lithium relative to sodium. A series of 88 kidney preparations perfused with a solution containing 0.47 mmol/l lithium was compared to another of 52 kidney preparations perfused without lithium. Lithium reduced the tubular reabsorption of sodium but did not modify the elimination of potassium. There is a strong correlation between the tubular reabsorption of lithium and of sodium. The correlation between tubular reabsorption of lithium and filtered load demonstrates the existence of a glomerulo-tubular balance.
D000818:Animals; D001794:Blood Pressure; D005260:Female; D007668:Kidney / Q000378:metabolism*; D007684:Kidney Tubules / Q000378:metabolism; D008094:Lithium / Q000378:metabolism* / Q000652:urine; D009318:Natriuresis; D011188:Potassium / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains
D008094:Lithium; D011188:Potassium
Elimination du lithium par le rein de rat isolé.