The effect of lead upon urate nucleation.
Lead urate was crystallized from solutions originally containing 0.595 mM (10 mg%) urate and 0.297 mM PbCl2. In the absence of lead, monosodium urate does not nucleate unless the urate concentration exceeds 80 mg%. Lead urate crystals were negatively birefringent and had a distinct x-ray powder diffraction pattern. Crystals of monosodium urate nucleated on lead urate seed crystals when the urate concentration was 10 mg%. These studies indicate that with physiologic conditions of temperature, pH, and ionic strength, spontaneous nucleation of lead urate can be demonstrated.
D055598:Chemical Phenomena; D002621:Chemistry; D003460:Crystallization; D006073:Gout / Q000139:chemically induced; D006801:Humans; D007854:Lead / Q000494:pharmacology*; D007855:Lead Poisoning / Q000150:complications; D014527:Uric Acid
D014527:Uric Acid; D007854:Lead