[Pharmacological characterization of novel pyridazines. Part 1: Physicochemical parameters, acute toxicity and action on the central nervous system (author's transl)].
The author determined the distribution coefficients (in n-octanol/water) and the RM values (thin-layer chromatographically, using two solvent systems) of 17 newly synthetized pyridazines. These determinations evidenced that the majority of these compounds are relatively polar. Altogether the acute toxicity of the compounds under investigation may be regarded as weak, because LD50 values could be determined for only 10 of the orally applied 17 pyridazines. The characteristic features of acute toxicity caused by high doses of the compounds under investigation were a stimulation of the central nervous system associated with convulsions or a depressant action on the central nervous system. The screening tests performed to date do not permit to classify the compounds under investigation into defined groups of substances action on the central nervous system. In conjunction with data from the literature, the possible mechanisms of the attack of these novel pyridazines on the central nervous system are discussed.
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003975:Diazepam / Q000494:pharmacology; D004347:Drug Interactions; D006591:Hexobarbital / Q000494:pharmacology; D007928:Lethal Dose 50; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011724:Pyridazines / Q000494:pharmacology* / Q000633:toxicity
D011724:Pyridazines; D006591:Hexobarbital; D003975:Diazepam; D010433:Pentylenetetrazole
Pharmakologische Charakterisierung neuartiger Pyridazine. 1. Mitteilung: Physikochemische Parameter, akute Toxizität und zentralnervöse Wirksamkeit.