Papaverine bioavailability in delayed absorption formulations.
The bioavailability of non "normal-acting" and three "delayed" papaverine formulations was compared in twenty hospitalized human subjects. Papaverine was evaluated in the blood at the nanogram level by a highly sensitive, specific gas chromatographic method with electron capture detection. Only one of the three chronoid preparations had appropriately delayed bioavailability 89% in comparison to normal acting formulation.
D000328:Adult; D000368:Aged; D001682:Biological Availability; D003692:Delayed-Action Preparations; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D010208:Papaverine / Q000097:blood*
D003692:Delayed-Action Preparations; D010208:Papaverine