title: The site of action of beta-2-sympathomimetic bronchodilatators in patients with chronic obstructive airway disease.
abstract: Administration of fenoterol aerosol limited to the upper respiratory tract during intubation produced the same bronchodilatating effect as the usual administration to the whole respiratory tract by the metered-dose aerosols used clinically in patients with chronic obstructive airway disease. The site of action of the beta 2-sympathicomimetic drugs in this area of the respiratory tract appears to be in the sensory limb of the bronchoconstriction reflex.
mesh_terms: D000336:Aerosols; D000368:Aged; D001980:Bronchi / Q000187:drug effects / Q000503:physiopathology*; D001993:Bronchodilator Agents / Q000494:pharmacology; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004983:Ethanolamines / Q000627:therapeutic use*; D005280:Fenoterol / Q000627:therapeutic use*; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012018:Reflex
chemical_list: D000336:Aerosols; D001993:Bronchodilator Agents; D004983:Ethanolamines; D005280:Fenoterol