title: Electrical properties of isolated demyelinated rat nerve fibres.
abstract: Isolated large rat nerve fibres with diphtheria toxin induced paranodal demyelination were investigated. These fibres had increased membrane time constant of the demyelinated nodal segment, related to a large increase in capacitance (5 to 50 times). The resting conductance was less increased (2 to 3 times), meaning that the internodal axolemma has considerably higher resting resistance than the nodal membrane. A large variation in action potential amplitude was found which was unrelated to the size of the nodal widening and the passive electrical properties.
mesh_terms: D000200:Action Potentials; D000818:Animals; D003711:Demyelinating Diseases / Q000139:chemically induced; D004167:Diphtheria Toxin; D008564:Membrane Potentials; D009413:Nerve Fibers, Myelinated / Q000502:physiology*; D009431:Neural Conduction; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000187:drug effects
chemical_list: D004167:Diphtheria Toxin