[Activity of nonspecific hepatic oxidases and the biological effects of the antineoplastic antibiotic adriamycin].
It was shown in male CBA mice that toxic doses (15 and 20 mg/kg) of adriamycin (AD) inhibited the activity of nonspecific liver oxidases and noticeably increased the duration of the animals' sleep after injection of hexenal which is a substrate of this enzymatic system. The inhibitory effect of AD remained unchanged in the course of 9 days of the experiment. The nontoxic dose of AD (5 mg/kg) inhibited the activity of the enzymatic system on the 2nd--3rd days after the injection of the drug. Meanwhile the activity of the enzymatic system returned to the level seen in intact animals by days 5--6. The toxic action of AD declined on activation of nonspecific liver oxidases with phenobarbital and rose as a result of administering the inhibitor SKF 525-A. The authors discuss whether it is possible to use the data obtained for clinical application of AD.
D000818:Animals; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology*; D006591:Hexobarbital / Q000008:administration & dosage; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010088:Oxidoreductases / Q000378:metabolism*; D010634:Phenobarbital / Q000008:administration & dosage; D011335:Proadifen / Q000008:administration & dosage; D012890:Sleep / Q000187:drug effects
D004317:Doxorubicin; D011335:Proadifen; D006591:Hexobarbital; D010088:Oxidoreductases; D010634:Phenobarbital
Aktivnost' nespetsificheskikh oksidaz pecheni i biologicheskie éffekty protivoopukholevogo antibiotika adriamitsina.