The toxicology of 1-acetyl-2-methyl-2-formyl hydrazine (Ac-MFH).
The hepatotoxic and cancerogenic N-methyl-N-formyl hydrazine (MFH), which is formed from the mushroom poison, gyromitrin, by hydrolytic cleavage in vivo and in vitro during food processing, loses its hepatotoxicity and its influence on the renal function of rats after acetylation at the free NH2-moiety. The importance of MFH-acetylation with regard to an inhibition of microsomal conversion of MFH into a toxic nitrosamide is considered. The known genetically determined heterogeneity of the acetylation rate for hydrazine derivates in man may explain the observed differences in sensitivity towards the mushroom toxins.
D000818:Animals; D004231:Diuresis / Q000187:drug effects; D006591:Hexobarbital / Q000494:pharmacology; D008297:Male; D008763:Methylhydrazines / Q000633:toxicity*; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D008763:Methylhydrazines; C033098:1-acetyl-2-methyl-2-formylhydrazine; D006591:Hexobarbital; D006899:Mixed Function Oxygenases