title: Effect of prolactin and bromocriptine on intestinal transit in mice.
abstract: In vivo administration of relatively high concentrations of prolactin (PRL) enhanced gastrointestinal propulsion in mice. Pretreatment with atropine significantly abolished this effect of PRL while physostigmine enhanced it. The evidence confirms a cholinomimetic action for higher concentrations (20 microgram) of PRL on the intestinal tract. Bromocriptine per se produced a dose-dependent depression in transit while a combination of PRL and bromocriptine failed to significantly alter the transit as compared to the control.
mesh_terms: D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D010830:Physostigmine / Q000494:pharmacology; D011388:Prolactin / Q000494:pharmacology*
chemical_list: D001971:Bromocriptine; D009020:Morphine; D011388:Prolactin; D010830:Physostigmine