Nerve growth from nodes of Ranvier in inactive muscle.
Paralysis of mouse gluteus maximus muscles with botulinum toxin not only evoked the expected sprouting from nerve terminals but also induced growth from some nodes of Ranvier close to the endplate region. This finding shows that nerve degeneration is not essential for nodal sprouting and supports the hypothesis that inactive muscle liberates a motor nerve growth factor.
D000818:Animals; D001369:Axons / Q000502:physiology; D001905:Botulinum Toxins / Q000494:pharmacology; D005260:Female; D051379:Mice; D009046:Motor Neurons / Q000502:physiology; D009121:Muscle Denervation; D009410:Nerve Degeneration; D009416:Nerve Regeneration; D011901:Ranvier's Nodes / Q000187:drug effects / Q000502:physiology*
D001905:Botulinum Toxins