[Mechanisms of free radical liquid peroxidation activation during regional ischemia and subsequent reperfusion of the heart].
Experiments on 115 noninbred male rats demonstrated that activation of lipid free-radical peroxidation during transitory coronary insufficiency was observed both in myocardial ischemia and subsequent reperfusion of the heart. The increase in lipid chemiluminescence during the recovery of the coronary blood flow was more pronounced after long-term myocardial ischemia. It was shown that activation of lipid peroxidation during reperfusion was accompanied by the increment of the myocardial content of the peroxidants--adrenaline, oxygen and calcium ions. It is suggested that activation of lipid free-radical peroxidation may be one of the principal factors responsible for the increased myocardial alteration during reversible ischemia, as well as during temporary failure of the coronary blood flow seen in the coronary heart disease of man.
D000818:Animals; D002118:Calcium / Q000032:analysis; D003327:Coronary Disease / Q000378:metabolism*; D004837:Epinephrine / Q000032:analysis; D005609:Free Radicals; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008163:Luminescent Measurements; D008297:Male; D009206:Myocardium / Q000032:analysis / Q000378:metabolism*; D010100:Oxygen / Q000032:analysis; D051381:Rats; D013997:Time Factors
D005609:Free Radicals; D008054:Lipid Peroxides; D010100:Oxygen; D002118:Calcium; D004837:Epinephrine
O mekhanizmakh aktivatsii perekisnogo svobodnoradikal'nogo okisleniia lipidov pri regionarnoĭ ishemii i posleduiushcheĭ reperfuzzi serdtsa.