[Regulation of the fluid state of the blood in thymectomized rats following intravenous thrombin administration].
Experiments on rats have shown that after 3-4 months thymectomy leads to hypercoagulation followed by the increased level of fibrinogen. As compared with intact rats, the thymectomized animals manifested a less pronounced increase in the concentration of the anticoagulants, and less stimulation of fibrinolysis in response to intravenous injection of thrombin. This is regarded as one of the reasons for a more frequent death of the operated animals.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis / Q000187:drug effects; D007275:Injections, Intravenous; D051381:Rats; D013917:Thrombin / Q000494:pharmacology*; D013934:Thymectomy; D013950:Thymus Gland / Q000502:physiology*
D005340:Fibrinogen; D013917:Thrombin
Reguliastsiia zhidkogo sostoianiia krovi u timéktomirovannykh krys pri vnutrivenom vvedenii trombina.