[Characteristics of the structural state of the erythrocyte membrane in rats with spontaneous genetic hypertension].
The structure of the surface and internal hydrophobic areas of the erythrocyte membranes of spontaneously hypertensive rats (SHR) was studied by means of fluorescent probes. The dependences on temperature of the fluorescence intensities of 1-aniline-naphthalene-8-sulfonate and N-phenyl-1-naphthylanine as well as the fluorescence spectra of pyrene and NN fluorescence polarization anisotropy of diphenylhexatriene wee analysed. It was found that the structure of the SHR erythrocyte membranes is altered. This alteration was interpreted as increasing of the membrane microviscosity at the areas of lipid -- protein contacts.
D000818:Animals; D001809:Blood Viscosity; D002458:Cell Fractionation / Q000379:methods; D002469:Cell Separation / Q000379:methods; D004910:Erythrocyte Membrane / Q000201:enzymology / Q000473:pathology*; D004912:Erythrocytes / Q000473:pathology*; D005456:Fluorescent Dyes; D006973:Hypertension / Q000235:genetics / Q000473:pathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013499:Surface Properties
D005456:Fluorescent Dyes
Osobennosti strukturnogo sostoianiia membrany éritrotsitov krys so spontannoĭ geneticheskoĭ gipertenzieĭ.