Estradiol treatment decreases type A and increases type B monoamine oxidase in specific brain stem areas and cerebellum of ovariectomized rats.
Ovariectomized rats were given either acute (50 micrograms 12 h or 24 h before sacrifice) or chronic (2 micrograms/day for one month) subcutaneous administration of 17 beta-estradiol. The activities of both type A and type B monoamine oxidase (MAO) in the cerebellum and in the areas A1, A2, and locus coeruleus of the brain stem were determined. The activity of type B MAO was increased by acute and chronic estrogen treatment in the different areas studied, whereas that of type A MAO did not change in the areas A1 and A2 and was decreased in the locus coeruleus and the cerebellum. These results indicate a discriminative action of estrogens on different forms of monoamine oxidase.
D000818:Animals; D001933:Brain Stem / Q000187:drug effects / Q000201:enzymology*; D002369:Castration; D002531:Cerebellum / Q000187:drug effects / Q000201:enzymology*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008995:Monoamine Oxidase / Q000378:metabolism*; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains
D004958:Estradiol; D008995:Monoamine Oxidase