Studies on erythrocyte membrane. V. Haemolytic effect of methylsalicylate and its possible mechanism.
The haemolytic effect of methylsalicylate (MS) on human and sheep erythrocytes is reported for the first time to our knowledge. Human erythrocytes are more sensitive to this effect. Haemolysis is proportional to the concentration of methylsalicylate and the duration of incubation. Lowering of surface tension and the ensuing membrane damage appear to be the mechanism by which the haemolytic effect is produced.
D004910:Erythrocyte Membrane / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D008563:Membrane Lipids / Q000097:blood; D010743:Phospholipids / Q000097:blood; D012459:Salicylates / Q000633:toxicity*; D013261:Sterols / Q000097:blood; D013500:Surface Tension
D008563:Membrane Lipids; D010743:Phospholipids; D012459:Salicylates; D013261:Sterols; C033069:methyl salicylate