title: Relative contribution of carotid and aortic bodies to cyanide-induced ventilatory responses in the cat.
abstract: The participation of afferences from carotid and aortic bodies to the hyperventilation caused by cytotoxic hypoxia was assessed in pentobarbitone-anesthetized cats. Dose-response curves for the ventilatory effects induced by i.v. injections of NaCN were obtained before and after successive denervations of peripheral chemoreceptors, in different sequences. Bilateral aortic neurotomy (BAN) or unilateral carotid neurotomy (UCN) did not affect significantly the minimal sensitivity to the drug, although maximal reactivity was reduced in some cats. After bilateral carotid neurotomy (BCN), with preservation of aortic nerves, sensitivity was reduced, but hyperventilation was still provoked by large doses of cyanide. BAN + BCN abolished the ventilatory responses to the drug. In cats with BAN + UCN, ventilatory responses had a high degree of correlation with increases of carotid chemosensory discharges in the range between ca 200% of control and the gasping threshold. It is concluded that the aortic bodies of the cat play a significant role in the hyperventilation produced by cytotoxic hypoxia, although it is less marked than that induced through the carotid bodies.
mesh_terms: D000818:Animals; D001016:Aortic Bodies / Q000187:drug effects*; D002344:Carotid Body / Q000187:drug effects*; D002415:Cats; D002628:Chemoreceptor Cells / Q000187:drug effects; D003486:Cyanides / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009474:Neurons / Q000502:physiology; D010234:Paraganglia, Nonchromaffin / Q000187:drug effects*; D012119:Respiration / Q000187:drug effects*; D012966:Sodium Cyanide / Q000494:pharmacology*
chemical_list: D003486:Cyanides; D012966:Sodium Cyanide