The respiration pathways of wild-type and petite mutants of Kluyveromyces lactis.
The existence of two alternative respiration pathways in Kluyveromyces lactis has been confirmed. Both pathways may be demonstrated in petite mutants of this yeast, suggesting that the major components in these pathways have an extramitochondrial origin. The antimycin A insensitive/sodium azide insensitive pathway (pathway I) is abolished by glucose repression of this yeast, whereas the antimycin A insensitive/sodium azide sensitive pathway (pathway II) is unaffected by this treatment. In K. lactis wild-type cells, the antimycin A insensitive/sodium azide sensitive respiration pathway (pathway II) is inhibited by salicyl hydroxamic acid, and this inhibition may be overcome upon addition of exogenous Fe3+ ions. This pathway in petite cells is unaffected by the presence of this inhibitor. The possible reasons for this are discussed.
D000968:Antimycin A / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D001386:Azides / Q000494:pharmacology; D002712:Chlorides; D005290:Ferric Compounds / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D009154:Mutation; D010101:Oxygen Consumption / Q000187:drug effects; D004718:Saccharomycetales / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D012457:Salicylamides / Q000494:pharmacology; D019810:Sodium Azide
D001386:Azides; D002712:Chlorides; D005290:Ferric Compounds; D012457:Salicylamides; D000968:Antimycin A; C005703:salicylhydroxamic acid; D019810:Sodium Azide; D005947:Glucose; C024555:ferric chloride