Screening system for the evaluation of preparations with potential cytostatic and immunotropic activity. I. Derivatives of 4,5-dihydro-2h-pyridazinone-3.
New screening system for the evaluation of preparations with potential cytostatic and immunotropic activity has been suggested. It consists in their interaction in relation to the mitogenic activity of phytohemagglutinin. A group of preparations, derivatives of 4,5-dihydro-2H-pyridazinone-3 was evaluated. It appeared that among the examined compounds there were preparations suppressing or stimulating the incorporation of 14C-thymidine to lymphocyte nuclei. Dependence between chemical structure and pharmacological activity in this group of compounds is discussed.
D000970:Antineoplastic Agents / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D010835:Phytohemagglutinins / Q000494:pharmacology; D011724:Pyridazines / Q000494:pharmacology*
D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D010835:Phytohemagglutinins; D011724:Pyridazines