title: [HPLC of trapidil (Rocornal) and metabolites (author's transl)].
abstract: Trapidil (1; Rocornal) and 10 metabolites can be separated by a gradient technique on reversed phases (RP-8 instant columns) using the eluents methanol/water and acetonitrile/phosphate buffer (pH = 5.4); ultraviolet detection. Furthermore, HPLC techniques for purity testing and for determining 1 in serum are described.
mesh_terms: D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D007700:Kinetics; D011743:Pyrimidines / Q000032:analysis*; D051381:Rats; D014192:Trapidil / Q000032:analysis* / Q000097:blood / Q000378:metabolism
chemical_list: D011743:Pyrimidines; D014192:Trapidil
vernacular_title: HPLC von Trapidil (Rocornal) und Metaboliten.