Effect of a neurotic pesticide, endosulfan, on tissue blood flow in cats, including regional cerebral circulation.
The effect of a neurotoxic pesticide, endosulfan (0.5, 1.0 or 2 mg/kg iv) was studied in pentobarbital anesthetized and paralysed cats on systemic and regional hemodynamic variables using the radioactive microsphere technique. The pesticide caused hypertension, pupillary dilatation and an increase in cardiac output and peripheral resistance. Since the above changes coincided with spike discharges in the EEG, and since there was also a profuse salivation indicating augmentation of parasympathetic activity as well, endosulfan was apparently acting within the brain to increase autonomic activity. The microsphere technique revealed that the cardiac output was preferentially redistributed to the heart and the brain at the cost of the fraction going to the kidneys, lungs, muscles and large intestine. In particular, there was a tremendous increase in cerebral blood flow (6 folds) which was more marked in diencephalon and cerebral hemispheres. Though enhanced brain metabolism due to EEG seizures is undoubtedly responsible for the increase in cerebral blood flow it is probably not the only factor. In conclusion, endosulfan acts within the brain to produce both autonomic and somatic toxicity.
D000818:Animals; D001784:Blood Gas Analysis; D002302:Cardiac Output / Q000187:drug effects; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects; D004569:Electroencephalography; D004726:Endosulfan / Q000633:toxicity*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D008297:Male
D004726:Endosulfan