Mechanisms of control of prolactin release in response to apprehension stress and anesthesia-surgery stress.
The response of prolactin to stress may not be controlled by a single mechanism. This study was designed to measure the prolactin response in the human female to two reproducible stresses: the apprehension (A) prior to surgery (laparoscopy and hysteroscopy) and the stress of the anesthesia-surgery (AS). Attempts to modify the release of prolactin was made by pharmacologic means. Thirty-eight normally menstruating women served either as controls or received histamine (H1), serotonin, opioid, or dopamine receptor-blocking agents and the prolactin response was measured. The release of prolactin to AS was blunted by higher-dose of opioid and by dopamine antagonists. The A release of prolactin was enhanced by the dopaminergic antagonist and blunted by the other three agents. It was concluded that the mechanism for the stress-induced release of prolactin may vary depending upon the nature of the stress.
D000328:Adult; D000758:Anesthesia; D001007:Anxiety / Q000097:blood; D002744:Chlorpheniramine / Q000494:pharmacology; D003533:Cyproheptadine / Q000494:pharmacology; D005260:Female; D006801:Humans; D009270:Naloxone / Q000494:pharmacology; D010868:Pimozide / Q000494:pharmacology; D011388:Prolactin / Q000097:blood*; D013312:Stress, Physiological / Q000097:blood*; D013315:Stress, Psychological / Q000097:blood*; D013514:Surgical Procedures, Operative
D010868:Pimozide; D003533:Cyproheptadine; D009270:Naloxone; D002744:Chlorpheniramine; D011388:Prolactin