[Hairy cell leukaemia with severe bone marrow insufficiency. Complete remission after chemotherapy in two patients (author's transl)].
Comple remission was obtained in two patients with hairy cell leukaemia and severe bone marrow insufficiency, using combined chemotherapy (rubidazone, arabinosyl cytosine, 6-mercaptopurine and cyclophosphamide). The remissions -- as demonstrated by normal blood cell counts and differentials and complete disappearance of hairy cells and fibrosis in bone marrow biopsies -- have now persisted for 6 and 3 months respectively. Intensive chemotherapy should be considered in patients who, after splenectomy, still have severe bone marrow depletion with persistent anaemia, neutropenia and/or life-threatening thrombocytopenia. Protected environment in a haematology intensive care unit is a prerequisite of intensive chemotherapy in such patients.
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001855:Bone Marrow Diseases / Q000209:etiology*; D004359:Drug Therapy, Combination; D006801:Humans; D007362:Intensive Care Units; D007943:Leukemia, Hairy Cell / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010198:Pancytopenia / Q000209:etiology; D055728:Primary Myelofibrosis / Q000209:etiology; D011379:Prognosis
D000970:Antineoplastic Agents
Leucémies à tricholeucocytes à la phase d'insuffisance médullaire sévère. Rémission complète après polychimiothérapie chez deux malades.