3-Hydroxyrifamycin S and further novel ansamycins from a recombinant strain R-21 of Nocardia mediterranei.
The structures of 3-hydroxyrifamycin S and six further novel ansamycins isolated from the recombinant strain R-21 of Nocardia mediterranei were identified by spectroscopic methods. Three types of structure were distinguished: Type 1: Ansamycins of the rifamycin S type Type 2: Ansamycins of the rifamycin G type Type 3: Ansamycins of the rifamycin W type.
D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D001419:Bacteria / Q000187:drug effects; D047029:Lactams, Macrocyclic; D008826:Microbial Sensitivity Tests; D009615:Nocardia / Q000032:analysis* / Q000235:genetics; D011995:Recombination, Genetic; D012294:Rifamycins / Q000302:isolation & purification*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D047029:Lactams, Macrocyclic; D012294:Rifamycins