title: Extrinsic allergic alveolitis caused by pigeon breeding at a high altitude (2,240 meters). Hemodynamic behavior of pulmonary circulation.
abstract: The hemodynamic characteristics of the pulmonary circulation were examined in 10 patients with proved extrinsic allergic alveolitis caused by pigeons (EAA-P) raised at a high altitude. All patients had lung biopsies that showed an interstitial inflammatory response with vascular lesions. At rest, all patients had mean pulmonary pressures (PAP) greater than 16 mmHg; the average PAP was 22 +/- 12 mmHg for the whole group. Pulmonary vascular resistance was high and the mean for the whole group was 225 +/- 25 d.s.cm-5. The pulmonary artery diastolic-pulmonary wedge pressure (PAd-PWP) difference was elevated and averaged 8.5 +/- 2 mmHg. All patients were hypoxemic with elevated AaDO2. With exercise, both PAP and PAd-PWP increased abnormally. While breathing oxygen (FIO2, 99.6%) PAP decreased an average of 7 mmHg (p less than 0.05) and PAd-PWP decreased an average of 5 mmHg (p less than 0.05) without a significant change in PWP. The calculated compliance of the elastic pulmonary arteries in EAA-P was not different from that in normal subjects. Alveolar hypoxia produced mainly by EAA-P and presumably enhanced by living at a high altitude appeared to be the factors in the genesis of pulmonary hypertension, because pulmonary artery diastolic pressure and PAd-PWP difference were correlated with arterial oxygen saturation.
mesh_terms: D000328:Adult; D000531:Altitude; D000542:Alveolitis, Extrinsic Allergic / Q000503:physiopathology*; D001716:Bird Fancier's Lung / Q000473:pathology / Q000503:physiopathology*; D001794:Blood Pressure; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology; D008168:Lung / Q000473:pathology; D008297:Male; D005082:Physical Exertion; D011652:Pulmonary Circulation; D011669:Pulmonary Wedge Pressure; D012129:Respiratory Function Tests; D014655:Vascular Resistance