Induction of rapid mood cycling during L-dopa treatment in a bipolar patient.
The authors report a longitudinal case study of a woman with a history of bipolar affective disorder in which L-dopa shortened the manic-depressive cycle length when administered in a double-blind trial. This finding suggests a dopaminergic mechanism specifically in changing the frequency of cycling between depression and mania.
D001714:Bipolar Disorder / Q000139:chemically induced* / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects* / Q000627:therapeutic use; D008734:Methoxyhydroxyphenylglycol / Q000652:urine; D008875:Middle Aged
D007980:Levodopa; D008734:Methoxyhydroxyphenylglycol