title: The carotid sinus-blood pressure reflex in conscious rabbits: the relative importance of changes in cardiac output and peripheral resistance.
abstract: This paper reports experiments to determine the relative roles of changes in cardiac output and systemic vascular resistance in determining the blood pressure response to intermittent step-changes and continuous sinusoidal changes in carotid sinus transmural pressure. Conscious rabbits with a variable-pressure capsule implanted around an innervated carotid sinus were used. After step-change in capsule pressure the approximate proportions of the changes in blood pressure attributable to changes in cardiac output were, during the pressor response, 7% after 2.5 s, 22% after 10 s and 27% at plateau, and during the depressor response 100%, 8% and 17%, respectively. During sinusoidal change in capsule pressure a mean 7% of the change in blood pressure over the full cycle was attributable to change in cardiac output.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002302:Cardiac Output; D002346:Carotid Sinus / Q000502:physiology*; D006339:Heart Rate; D011311:Pressoreceptors / Q000502:physiology; D011817:Rabbits; D012018:Reflex / Q000502:physiology*; D014655:Vascular Resistance