Choreo-athetosis induced by phenytoin in an epileptic child. A case report.
A 5-year-old child with epilepsy and underlying brain damage developed choreo-athetosis during intoxication with phenytoin. Drug intoxication was suggested by the dose the child was taking (75 mg 3 times a day) and confirmed by measuring the serum phenytoin concentration which was 229 mmol/l (therapeutic range 40-80 mmol/l). The choreoathetoid movements ceased 4 weeks after discontinuation of the drug, although the blood level returned to the therapeutic range after 2 weeks.
D001264:Athetosis / Q000139:chemically induced*; D002675:Child, Preschool; D002819:Chorea / Q000139:chemically induced*; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000009:adverse effects*
D010672:Phenytoin