Blockade of nicotinic receptors in brain with d-tubocurarine induces decreased metabolism, cutaneous vasodilation and hypothermia in rats.
Direct administration of d-tubocurarine into the lateral cerebral ventricle of conscious rats produced decreased metabolism, cutaneous vasodilatation and hypothermia at ambient temperatures of 8--22 degrees C. Also, pretreatment with d-tubocurarine antagonized the arecoline-induced hypothermia.
D000818:Animals; D001115:Arecoline / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects*; D001833:Body Temperature Regulation / Q000187:drug effects; D007700:Kinetics; D008297:Male; D008660:Metabolism / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011978:Receptors, Nicotinic / Q000187:drug effects*; D012867:Skin / Q000098:blood supply; D014403:Tubocurarine / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects*
D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic; D001115:Arecoline; D014403:Tubocurarine