title: The suppressive effect of meperidine on PHA-stimulated transformation of human lymphocytes.
abstract: The effect of meperidine on the response of human peripheral lymphocyte in culture to the stimulation by the mitogen, phytohemagglutinin, was studied by measuring the incorporation of 3H-thymidine into DNA. The addition of meperidine at a high concentration (40-200 micrograms/ml) resulted in significant decrease in response to mitogen, the inhibition being dose-dependent. Meperidine may influence immune responses by altering DNA synthesis in the lymphocytes.
mesh_terms: D002118:Calcium / Q000378:metabolism; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008614:Meperidine / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism
chemical_list: D010835:Phytohemagglutinins; D008614:Meperidine; D002118:Calcium; D013936:Thymidine