[Role of peroxides in changes in brain mitochondria energy metabolism following exposure to schizophrenic patients' serum].
Antioxidants normalize some of the characteristics of energy metabolism in mitochondria from the rat cerebral cortex, altered as a result of exposure to blood serum from patients suffering from continuous schizophrenia. Meanwhile, antioxidants proved little effective after administration of blood serum from patients with attach-like schizophrenia. The whole blood serum and low-molecular fractions (ultrafiltrate, protein-free) obtained from it (the first group of patients) increased the intensity of malonic dialdehyde accumulation by the test system, whereas in the second group of patients, this process, exposed to the analogous blood fractions, proceeded less violently. It is concluded that one of the reasons for alterations in energy metabolism exposed to blood serum from patients with continuous schizophrenia is the toxic action of peroxidation products.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002415:Cats; D002540:Cerebral Cortex / Q000378:metabolism*; D004734:Energy Metabolism; D005978:Glutathione / Q000494:pharmacology; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D066298:In Vitro Techniques; D008315:Malondialdehyde / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D010545:Peroxides / Q000378:metabolism*; D012559:Schizophrenia / Q000097:blood*
D000975:Antioxidants; D007106:Immune Sera; D010545:Peroxides; D008315:Malondialdehyde; D005978:Glutathione
Rol' perekiseĭ v izmenenii énergeticheskogo metabolizma v mitokhondriiakh mozga pri vozdeĭstvii syvorotki krovi bol'nykh shizofrenieĭ.