title: [Glucocorticoid kinetics in Cushing's syndrome treated with chloditane and large doses of reserpine].
abstract: The paper is concerned with the results of the studies on corticosteroid kinetics (secretion rate, distribution volume, metabolic blood clearance, mean daily blood cortisol content and excretion of free hormone with urine) in 44 patients suffering from Icenko-Cushing's disease, treated with chloditane and/or chloditane combined with massive reserpine doses. The above parameters increased in Icenko-Cushing's disease during clinical remission after chloditane or chloditane and reserpine treatment. No differences between effects on glucocorticoid secretion and metabolism after the treatment with chloditane or chloditane in combination with high reserpine doses were recorded.
mesh_terms: D000293:Adolescent; D000328:Adult; D003345:Corticosterone / Q000378:metabolism*; D003480:Cushing Syndrome / Q000188:drug therapy / Q000378:metabolism*; D004359:Drug Therapy, Combination; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007700:Kinetics; D008875:Middle Aged; D008939:Mitotane / Q000008:administration & dosage; D012110:Reserpine / Q000008:administration & dosage
chemical_list: D008939:Mitotane; D012110:Reserpine; D003345:Corticosterone; D006854:Hydrocortisone
vernacular_title: Kinetika gliukokortikoidov u bol'nykh bolezn'iu Itsenko-Kushinga, lechennykh khloditanom i bol'shimi dozami rezerpine.