title: [Cytogenetic activity of the harmful insect chemosterilant, dimatif, on mouse bone marrow cells].
abstract: The new insects' chemosterilant, dimatyph, (diethylene-imide amidothiophosphorous acid) induced a significant increase of chromosomal aberrations in the mouse bone marrow cells after a single per os treatment in doses of 100.0, 10.0, 1.0, 0.1 mg/kg. An extremely high mutagenic activity of dimatyph (maximal cytogenetic effect 33.6%, minimal effective dose 1.0 mg/kg) does not permit a widespread use of this substance as a pesticide.
mesh_terms: D000818:Animals; D001388:Aziridines / Q000494:pharmacology*; D001389:Azirines / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects*; D002629:Chemosterilants / Q000494:pharmacology*; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D051379:Mice; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*
chemical_list: D001388:Aziridines; D001389:Azirines; D002629:Chemosterilants; D009946:Organothiophosphorus Compounds; C026085:dimatiph
vernacular_title: Izuchenie tsitogeneticheskoĭ aktivnosti sterilianta vrednykh nasekomykh dimatifa na kletkakh kostnogo mozga mysheĭ.