[Convulsive seizures and polyneuritis in a patient with lupus treated with metronidazole (author's transl)].
A 20-year-old patient with biologically-confirmed lupus developed a perirenal abscess following puncture biopsy of the kidney. Postoperative treatment included metronidazole at a mean dose of 2.5 g daily for 68 days (total dose : 165 g). Generalised convulsive seizures occurred on four occasions, associated with paresthesia of the four limbs, but without loss of motor or reflex activity, though some distal hypoesthesia was detected. An acute lupus attack was eliminated, the convulsive seizures not recurring after discontinuation of treatment, and the paresthesias diminishing progressively over a period of three months. Electrical investigations showed lack of motor anomalies but a marked reduction in sensory conduction. This is the 13th reported case of polyneuritis due to metronidazole, the 4th case of convulsive seizures, and the first case in which both manifestations occurred. The plasma concentration curve after oral administration of 1 g of the product to this patient demonstrated that the product was not being metabolised in a pathological manner.
D000038:Abscess / Q000188:drug therapy / Q000209:etiology*; D000328:Adult; D001706:Biopsy / Q000009:adverse effects; D005260:Female; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000150:complications*; D008297:Male; D008795:Metronidazole / Q000009:adverse effects*; D008875:Middle Aged; D010292:Paresthesia / Q000139:chemically induced*; D012187:Retroperitoneal Space; D012640:Seizures / Q000139:chemically induced*
D008795:Metronidazole
Crises convulsives et polynévrite chez un lupique traité par le Métronidazole.