[Fecal excretion of neutral and acid sterols in patients with atherosclerosis with a progressive or stable course].
Within 6 years repeated studies were carried out in 525 men including 54 atherosclerotic patients without any impairments of liver tissue and 73 healthy people out of which 33 were older and younger than 40. The level of fecal excretion of acid and, especially, neutral sterols was distinctly higher in the patients with progressive atherosclerosis than in the stable phase of the disease. In the healthy persons older than 40 the sterol excretion was also increased but, mainly, due to an elevation in content of bile acids, accounting for the increased level of fecal cholate-cholesterol index. High content of sterols in feces and of lipids in blood of patients with progressive atherosclerosis might be related to an increased synthesis of cholesterol as well as to a decrease in activity of liver enzymatic systems, oxidizing cholesterol into bile acids.
D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000378:metabolism*; D002784:Cholesterol / Q000032:analysis / Q000097:blood; D002793:Cholic Acids / Q000032:analysis; D005243:Feces / Q000032:analysis*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D013261:Sterols / Q000032:analysis*; D014280:Triglycerides / Q000097:blood
D002793:Cholic Acids; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D013261:Sterols; D014280:Triglycerides; D002784:Cholesterol
Fekal'naia ékskretsiia neĭtral'nykh i kislykh sterinov u bol'nykh s progressiruiushchim i stabil'nym techeniem ateroskleroza.