Antitumor and toxohormone-neutralizing activities of human ceruloplasmin.
Human ceruloplasmin was found to have a neutralizing effect against the toxohormone activities of the basic protein isolated from Ehrlich carcinoma cells; this basic protein decreases the levels of serum iron and liver catalase activity upon intraperitoneal injection into mice and shows direct cytotoxicity toward normal mouse lymphocytes and macrophages. Furthermore, it was also shown that ceruloplasmin has antitumor activity against sarcoma-180 cells implanted in ICR mice.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002374:Catalase / Q000037:antagonists & inhibitors*; D002570:Ceruloplasmin / Q000494:pharmacology*; D004731:Endotoxins / Q000037:antagonists & inhibitors*; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood; D008099:Liver / Q000201:enzymology; D051379:Mice; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors*; D012510:Sarcoma 180 / Q000188:drug therapy
D000970:Antineoplastic Agents; D004731:Endotoxins; D009363:Neoplasm Proteins; C010355:toxohormone; D007501:Iron; D002374:Catalase; D002570:Ceruloplasmin