The formation of N-nitrosomethyl(2-oxopropyl)amine from N-nitrosobis(2-oxopropyl)amine in vivo.
After injection of N-nitrosobis(2-oxopropyl)amine (BOP) (10 mg/kg) to male Syrian golden hamsters there were there concentrations of BOP and many of its metabolites in the hamster pancreas compared with the liver and salivary gland. Also, a potential methylating metabolite of BOP, N-nitrosomethyl(2-oxopropyl)amine, was found in both tissues.
D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000378:metabolism*; D002849:Chromatography, Gas; D006224:Cricetinae; D008297:Male; D008647:Mesocricetus; D009602:Nitrosamines / Q000378:metabolism*; D014018:Tissue Distribution
D002273:Carcinogens; D009602:Nitrosamines; C028133:N-nitrosomethyl-2-oxopropylamine; C013622:nitrosobis(2-oxopropyl)amine