Antianginal effect of nifedipine after intracoronary and intravenous administration judged by reduction of ischemic ST-segment depression in exercise tests.
The purpose of the study was to distinguish between the peripheral and the cardiac mode of action of nifedipine, a drug which inhibits transmembrane calcium transport. To assess the cardiac and peripheral antianginal effect independently, two routes of application were employed: systemic intravenous and intracoronary infusion into the left coronary artery of approximately equipotent doses.
D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D004562:Electrocardiography; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007261:Infusions, Intra-Arterial; D007275:Injections, Intravenous; D009543:Nifedipine / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*
D011725:Pyridines; D009543:Nifedipine