Heart lipidosis induced by short-term feeding of cis- or trans-docosenoic acids in weanling or 7-week-old rats.
Weanling male rats were fed calcium-deprived diets containing 15% lipids, of which half is cis- or trans-docosenoic acid, for 5, 12 or 28 days. Elaidic or oleic acid-fed rats served as controls. After 5 days on diet, the rats fed brassidic acid showed heart triglyceride accumulation, but less than the erucic acid-fed rats. In both groups, the heart triglyceride content decreased with time and returned to normal values after 28 days. When similar diets were fed for 12 days to 7-week-old rats, brassidic acid, on the contrary, induced a greater triglyceride accumulation than erucic acid did.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D009202:Cardiomyopathies / Q000139:chemically induced*; D004032:Diet; D004883:Erucic Acids / Q000494:pharmacology*; D005227:Fatty Acids / Q000032:analysis; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D008064:Lipidoses / Q000139:chemically induced*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D014280:Triglycerides / Q000378:metabolism
D004883:Erucic Acids; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D014280:Triglycerides