[Effect of the intermittent and continuous action of dimethylformamide on adaptation processes].
Two series of experiments were carried out with 960 mg/kg and 3840 mg/kg DMF, applied dermally to albino rats every second, third day and daily as well. The treatment scheme quarantees equitoxic quantities of DMF with a dynamic observation by the 4th, 8th, 14th and 28th day from the beginning of the exposure and after 14 days of rehabilitation. The complex investigation with integral and specific clinical-laboratory tests revealed a cumulation of the toxic effect with progressing changes in the liver function, better manifested with the intermittent regimes. The dose of 3840 mg/kg induced distinct deviations in the lipid metabolism and serum enzymes. In contact with 960 mg/kg DMF, a phase-state was established during the first terms of observation with the development of adaptation under a monotonous effect and absence of restoration -- mainly in case of intermittent effect. Dermal toxicity of DMF should be given consideration in the assessment of the risk from exposure during production of polyacryl fibres.
D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D001769:Blood / Q000187:drug effects; D004126:Dimethylformamide / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012869:Skin Absorption / Q000187:drug effects; D013997:Time Factors
D004126:Dimethylformamide
Vliianie na intermitentnoto i monotonno deĭstvie na dimetilformamida vŭrkhu protsesite na adaptatsiia.