Late haemodynamic response to metrizamide and ioxaglate in canine renal angiography. Preliminary report.
The renal blood flow as examined in six dogs for 2 h after contrast agent injection into the renal artery using the dye dilution method. After injection of an ionic contrast agent (iodamide) there was an initial vasodilatation and later constriction, but the blood flow was back to normal after 10-15 min. Ioxaglate caused a similar initial response, but after a relatively large dose the blood flow remained below normal for 2 h. Metrizamide caused an immediate reduction in the blood flow, which remained constantly reduced for 2 h. A total cessation of the renal blood flow was seen in two cases.
D000792:Angiography / Q000379:methods*; D000818:Animals; D003287:Contrast Media / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D007451:Iodamide / Q000494:pharmacology; D007463:Iodobenzoates / Q000494:pharmacology*; D007485:Ioxaglic Acid; D007668:Kidney / Q000098:blood supply*; D008297:Male; D008793:Metrizamide / Q000494:pharmacology*; D012079:Renal Circulation / Q000187:drug effects; D014283:Triiodobenzoic Acids / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D007451:Iodamide; D008793:Metrizamide; D007485:Ioxaglic Acid