[Changes in the neurochemical properties of midbrain reticular neurons during negative emotional responses].
Qualitative changes in responses of singly neurons of hte midbrain reticular formation to microionophoretically applied acetylcholine (ACh), serotonin (5-OT) and noradrenaline (NA) were revealed during stimulation of the "fear" centre in experiments on non-narcotized and non-immobilized rabbits. Approximately 50% of te units studied displayed changes which were manifested by occurrence or elimination of he responses or by reduction or activation of he responses to one or some agents. Afer ventromedial hypothalamic stimulation changes in chemical sensitivity of the reticular neurons were twice as often to NA and 5-OT than to ACh. A supposition is made that alteration in neurochemical properties of the central neurons can be one of the mechanisms of the development of negative emotional states.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001679:Biogenic Amines / Q000494:pharmacology*; D001931:Brain Mapping; D004558:Electric Stimulation; D004644:Emotions / Q000502:physiology*; D007031:Hypothalamus / Q000502:physiology*; D007033:Hypothalamus, Middle / Q000502:physiology*; D008636:Mesencephalon / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011817:Rabbits; D012154:Reticular Formation / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology
D001679:Biogenic Amines; D012701:Serotonin; D000109:Acetylcholine; D009638:Norepinephrine
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