title: Regression of the baroreceptor resetting in hypertension of long duration in rats.
abstract: 1. The extent of reversal of baroreceptor resetting after pressure normalization was studied in rats with renal hypertension of up to 6 months duration. The aortas of these rats when compared with those of 2 month hypertensive rats were thicker (44%) and had a larger calibre (29%). 2. The more severe morphological alterations found in the 6 month hypertensive rats did not interfere with the reversibility of the resetting process. The entire range of pressure for baroreceptor activation showed a small downward displacement after 1 h and was functioning at a completely normal pressure 6 h after pressure normalization. 3. The data show that reversal of resetting from hypertension is a very rapid process that is independent of the duration of hypertension and the severity of morphological lesions. Moreover, they indicate that reversal is a permanent phenomenon because it was also observed after 2 days of pressure normalization.
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000294:innervation; D001794:Blood Pressure; D006977:Hypertension, Renal / Q000503:physiopathology*; D006978:Hypertension, Renovascular / Q000503:physiopathology*; D008297:Male; D011311:Pressoreceptors / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000502:physiology