title: Effect of injected human chorionic gonadotrophin on capillary permeability, extracellular fluid volume and the flow of lymph and blood in the testes of rats.
abstract: The subcutaneous injection of human chorionic gonadotrophin (HCG) into adult male rats caused appreciable rises in capillary permeability and lymph flow in the testis, accompanied by smaller rises in the volume of extratubular, extracellular fluid. Most of these changes were already apparent 8 h after injection, but became progressively greater during the next 12 h. Testicular blood flow was unchanged at 12 h but increased slightly between 12 and 6 h after injection. The primary effect is probably the increase in capillary permeability. The timing of these changes suggests that HCG does not affect the capillaries directly, but it would seem that the changes are due to some substances secreted by the testis in response to the HCG. It is clear that these changes will have important influences both on the access to the testicular cells of peptide hormones in the blood and also on the passage into the venous blood of hormones secreted by the testis.
mesh_terms: D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D005110:Extracellular Space / Q000187:drug effects / Q000378:metabolism*; D008196:Lymph / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D013737:Testis / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors
chemical_list: D006063:Chorionic Gonadotropin