Nickel carbonate induces DNA-protein crosslinks and DNA strand breaks in rat kidney.
DNA lesions were observed in kidney nuclei isolated from rats 20 h after i.p. injection with nickel carbonate. Dose-dependent, nickel-induced DNA crosslinks and DNA single strand breaks were detected using the alkaline elution technique. The DNA crosslinks were determined to be completely DNA-protein in nature. The DNA damage induced by nickel carbonate is discussed relative to the carcinogenicity of nickel compounds.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D004247:DNA / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D009532:Nickel / Q000633:toxicity*; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; D011506:Proteins; D009532:Nickel; D004247:DNA; C030989:nickel carbonate