Carcinogenicity of methylmercury chloride in ICR mice: preliminary note on renal carcinogenesis.
ICR mice (60/group) were fed diets containing methylmercury chloride (MMC) in 0, 15 or 30 ppm for 78 weeks. The majority of mice in the 30-ppm group died due to the neurotoxicity by week 26. The first renal mass was grossly seen in a male of the 15-ppm group at week 58. Histopathology on kidney tissue from all animals surviving after 53 weeks revealed renal tumors in 13 of 16 males of the 15-ppm group in contrast with 1 of 37 males of the control. No renal tumors were seen in the female treated groups and/or control groups.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008767:Methylmercury Compounds / Q000633:toxicity*; D051379:Mice; D008813:Mice, Inbred ICR; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology
D002273:Carcinogens; D008767:Methylmercury Compounds; C004925:methylmercuric chloride