Nonresponsiveness of serum high-density lipoprotein-cholesterol to high dose ascorbic acid administration in normal men.
In a prospective, single-blind, 12-wk study, serum lipids were measured serially in nine normal male volunteers before and during oral administration of megadose ascorbic acid (1 g vitamin C/day). Study results revealed no significant effect of vitamin therapy on serum cholesterol, high-density lipoprotein-cholesterol, triglycerides, or calculated low-density lipoprotein-cholesterol. Megadose ascorbic acid therapy is not effective in elevating serum high-density lipoprotein-cholesterol in normal adult men.
D000328:Adult; D001205:Ascorbic Acid / Q000008:administration & dosage*; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D011446:Prospective Studies; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol; D001205:Ascorbic Acid