Studies on premedication and ventilatory responses to minaxolone.
The effect of three premedications on induction, maintenance and recovery characteristics of minaxolone as a supplement to nitrous oxide and oxygen anesthesia were studied in 70 patients. Morphine and atropine premedication provided superior operative conditions with fewer side-effects when compared with atropine alone or diazepam and atropine. Recovery was significantly longer after minaxolone compared with a similar group of patients given Althesin. The ventilatory responses to the induction of anesthesia with minaxolone were measured in 25 patients. All patients showed an increase in respiratory frequency and a decrease in tidal volume. This effect was most marked in the group premedicated with diazepam and atropine.
D000328:Adult; D000777:Anesthetics; D001285:Atropine; D003975:Diazepam; D005260:Female; D006801:Humans; D008297:Male; D009020:Morphine; D009609:Nitrous Oxide; D010100:Oxygen; D011229:Preanesthetic Medication; D011278:Pregnanes / Q000494:pharmacology; D011280:Pregnanolone / Q000031:analogs & derivatives / Q000494:pharmacology; D012119:Respiration / Q000187:drug effects*; D013997:Time Factors
D000777:Anesthetics; D011278:Pregnanes; C020413:minaxolone; D009020:Morphine; D001285:Atropine; D011280:Pregnanolone; D009609:Nitrous Oxide; D003975:Diazepam; D010100:Oxygen