title: [Immunological indices of human vaccination against tick-borne encephalitis using inactivated preparations with a varying concentration of the viral antigen].
abstract: The results obtained in the determination of the immunological activity of 3 types of formalin-killed tissue-culture tick-borne encephalitis vaccine, commercial non-concentrated and concentrated by 2 different methods, in humans are presented. Judging by the data of 3 serological tests and the blast transformation test, the concentration of killed tick-borne encephalitis virus enhanced immune response to vaccination. The intensity of this response correlated with the mouse protection capacity of the vaccine batches under test. An increase in the content of viral particles in the preparation is considered to be a promising approach to enhancing the effectiveness of vaccination against tick-borne encephalitis.
mesh_terms: D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000008:administration & dosage*; D004306:Dose-Response Relationship, Immunologic; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology*; D004675:Encephalitis, Tick-Borne / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013997:Time Factors; D014611:Vaccination / Q000379:methods*; D014613:Vaccines, Attenuated / Q000008:administration & dosage; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines
vernacular_title: Immunologicheskie pokazateli vaktsinatsii liudeĭ protiv kleshchevogo éntsefalita inaktivirovannymi preparatami s raznoĭ kontsentratsieĭ virusnogo antigena.