Vitamin K-dependent carboxylation and vitamin K epoxidation. Evidence that the warfarin-sensitive microsomal NAD(P)H dehydrogenase reduces vitamin K1 in these reactions.
Passage of a Triton X-100-solubilized microsomal systems in vitro that are used to study these reactions is the warfarin-sensitive NAD(P)H dehydrogenase.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002846:Chromatography, Affinity; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D009243:NAD / Q000494:pharmacology; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D009249:NADP / Q000494:pharmacology; D011092:Polyethylene Glycols; D011808:Quinone Reductases / Q000378:metabolism*; D051381:Rats; D014812:Vitamin K / Q000378:metabolism*; D014859:Warfarin / Q000494:pharmacology*
D009243:NAD; D014812:Vitamin K; D011092:Polyethylene Glycols; D009249:NADP; D014859:Warfarin; D009247:NADH, NADPH Oxidoreductases; D011808:Quinone Reductases