The fate of intravenously injected trypsinogens in dogs.
After intravenous injection of autologous purified and radiolabeled anionic and cationic trypsinogens in the dog, there is a multiexponential elimination from serum of the trypsinogens without activation to active trypsins. The results are in agreement with an elimination of the trypsinogens iva glomerular filtration, a variable tubular uptake of anionic trypsinogen, and a complete tubular uptake of cationic trypsinogen. Fractional catabolic rates for anionic trypsinogen were 0.35-0.92 h-1 and for cationic trypsinogen 0.38-1.05 h-1. The total amount of anionic trypsinogen turned over in the circulation is estimated at approximately 0.55 mg every 24 h, and the corresponding figure for cationic trypsinogen is 0.35 mg/24 h.
D000818:Animals; D001711:Biotransformation; D004285:Dogs; D004765:Enteropeptidase / Q000378:metabolism; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D013997:Time Factors; D014018:Tissue Distribution; D014362:Trypsinogen / Q000008:administration & dosage / Q000378:metabolism*
D014362:Trypsinogen; D004765:Enteropeptidase