Hemodynamic determinants of pulmonary valve motion during systole in experimental pulmonary hypertension.
To clarify the determinants of pulmonary valve (PV) motion in pulmonary hypertension, we examined the correlations among PV echo patterns, the pulmonary artery (PA) flow curve just above the PA orifice and the pulmonary artery-right ventricle (PA-RV) pressure gradient. By constricting the PA, we could produce a variety of PV echo patterns, including midsystolic semiclosure in open-chest dogs. Throughout the experiments, the PV echo pattern and PA flow curve were similar in pattern and timing. When the PV echo showed midsystolic semiclosure with reopening. The PA flow curve showed a transient decrease followed by a transient increase during midsystole. The PA-RV pressure gradient became transiently positive (PA pressure greater than RV pressure) and then negative in midsystole only when the PV echo showed midsystolic semiclosure with reopening. In conclusion, PV motion during systole may be instantaneously determined by PA flow change and the PA-RV pressure gradient during the cardiac cycle in experimental pulmonary hypertension.
D000818:Animals; D003251:Constriction, Pathologic; D004285:Dogs; D004452:Echocardiography; D006439:Hemodynamics; D006976:Hypertension, Pulmonary / Q000503:physiopathology*; D009200:Myocardial Contraction; D011651:Pulmonary Artery / Q000503:physiopathology; D011652:Pulmonary Circulation; D011664:Pulmonary Valve / Q000503:physiopathology*; D013599:Systole; D013997:Time Factors