[Cytostatic action of 2-nitronaph-thofurans on L1210 murine leukemia cells in semi-solid médium (author's transl)].
The cytostatic effect of various derivatives of 2-nitro-naphthofurans has been determined in vitro on L1210 leukemia cells. A recently described new bio-assay (Discotest) was used, which consists in plating the cells in soft agarose and placing on top of the agarose layer a paper disc soaked with the compound to be tested. The halo of inhibition of colony formation which results from diffusion of the compound is proportional to the logarithm of the compound concentration. The most active derivatives were the 2-nitro-7-methoxy and 2-nitro-8-methoxy-naphtho[2,1-b] furans which are known to be highly bactericidal and protozoocidal.
D000818:Animals; D000970:Antineoplastic Agents / Q000032:analysis; D001572:Benzofurans / Q000494:pharmacology; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D003470:Culture Media; D066298:In Vitro Techniques; D007939:Leukemia L1210 / Q000188:drug therapy*; D051379:Mice; D009581:Nitrofurans / Q000032:analysis / Q000494:pharmacology
D000970:Antineoplastic Agents; D001572:Benzofurans; D003470:Culture Media; D009581:Nitrofurans; C030911:2-nitro-7-methoxynaphtho(2-1b)furan; C011496:2-nitro-8-methoxynaphtho(2,1-b)furan
Action cytostatique de nitro-2 naphtofurannes sur des cellules de la leucémie murine L1210, en milieu semi-solide.