Sympathomimetic amine-induced release of norepinephrine-3H from different intraneuronal storage compartments.
The effects of different loading procedures on norepinephrine-3H (NE-3H) efflux induced by a structurally analogous group of indirectly acting sympathomimetic amines was examined in rabbit vas deferens. (+)-Amphetamine was ineffective in releasing 3H from tissues with intact intraneuronal storage granules but was an effective depletor of (a) non-granular intraneuronal compartment(s) following in vivo treatment with reserpine. (+/-)-p-Hydroxynorephedrine was a less effective depletor of non-granular NE-3H. These experiments provide further evidence in support of multiple intraneuronal storage compartments which can be pharmacologically differentiated by utilizing indirectly acting sympathomimetic amine agents.
D000818:Animals; D003042:Cocaine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009526:Nialamide / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism*; D011817:Rabbits; D012110:Reserpine / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology*; D014649:Vas Deferens / Q000378:metabolism
D013566:Sympathomimetics; D012110:Reserpine; D003042:Cocaine; D009526:Nialamide; D004298:Dopamine; D006854:Hydrocortisone; D009638:Norepinephrine