Restorative effects of nandrolone decanoate on the mononuclear phagocyte system in tumor-bearing mice.
The effects of nandrolone decanoate on the mononuclear phagocyte system (MPS) were examined in normal or tumor-bearing mice. Bactericidal activity against Listeria monocytogenes, carbon clearance test and leukocyte accumulation into the site of inflammation were depressed when viable cells of sarcoma-180 were inoculated subcutaneously into ddY mice 24hr before the assays. Pretreatment with nandrolone decanoate prevented such depression in tumor-bearing mice and increased MPS activities of normal or tumor-bearing mice above the level of non-treated normal mice. Nandrolone decanoate may be useful for the augmentation of antimicrobial activity in tumor-bearing hosts.
D045930:Anabolic Agents / Q000494:pharmacology*; D000818:Animals; D001424:Bacterial Infections / Q000276:immunology; D002244:Carbon / Q000378:metabolism; D005260:Female; D007249:Inflammation / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077603:Nandrolone Decanoate; D009369:Neoplasms / Q000276:immunology*; D010586:Phagocytes / Q000187:drug effects* / Q000276:immunology; D010835:Phytohemagglutinins / Q000494:pharmacology; D012510:Sarcoma 180 / Q000276:immunology; D013154:Spleen / Q000382:microbiology
D045930:Anabolic Agents; D010835:Phytohemagglutinins; D009277:Nandrolone; D002244:Carbon; D000077603:Nandrolone Decanoate