Elevation of blood keto acids in cerebrocortical necrosis.
Values of various alpha-keto acids in whole blood were determined from cases of cerebrocortical necrosis (CCN), a thiamine deficiency disease, and were compared with those from normal animals. Thiamine pyrophosphate is an essential cofactor in the decarboxylation of many alpha-keto acids and this was reflected in elevated values not only of pyruvic acid but of glyoxylic, alpha-keto glutaric, phenyl pyruvic and hydroxyphenyl pyruvic acids in the CCN cases.
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood*; D002540:Cerebral Cortex / Q000473:pathology*; D006038:Glyoxylates / Q000097:blood; D007651:Keto Acids / Q000097:blood*; D007656:Ketoglutaric Acids / Q000097:blood; D009336:Necrosis; D010667:Phenylpyruvic Acids / Q000097:blood; D011773:Pyruvates / Q000097:blood; D019289:Pyruvic Acid; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood*; D013832:Thiamine Deficiency / Q000097:blood / Q000662:veterinary*
D006038:Glyoxylates; D007651:Keto Acids; D007656:Ketoglutaric Acids; D010667:Phenylpyruvic Acids; D011773:Pyruvates; C010590:4-hydroxyphenylpyruvic acid; D019289:Pyruvic Acid; C031150:glyoxylic acid; C031606:phenylpyruvic acid