Concentration of plasma middle molecular weight substances and clinical condition of patients undergoing short-time regular dialysis treatment.
Forty patients were dialysed 12 hours weekly for three years by 1 sq.m. Cuprophane coil dialyser. Clinical features, conventional laboratory data, concentration of middle molecular weight substances, and metabolic state were studied. No difference was found in the clinical picture during the short time dialysis schedule. Neither did the plasma concentration of middle molecular weight substances change substantially during this period. The metabolic state after three years of short time dialyses was good. The elimination of middle molecular weight substances by 1 sq.m. Cuprophane coil was sufficiently effective to prevent an excessive increase of their plasma level.
D003404:Creatinine / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D006435:Renal Dialysis; D013997:Time Factors; D014118:Toxins, Biological / Q000097:blood*; D014511:Uremia / Q000097:blood / Q000628:therapy*
D014118:Toxins, Biological; C026865:uremia middle molecule toxins; D003404:Creatinine