title: Hemodialysis, peritoneal dialysis, plasmapheresis and forced diuresis for the treatment of quinine overdose.
abstract: Peritoneal dialysis, hemodialysis, plasma exchange and forced diuresis have been reported to accelerate removal of quinine following quinine poisoning. All these modalities were used simultaneously to treat a 19 year old youth who had become blind as a result of an overdose of quinine tablets. The serum quinine level was measured at 10.5 microgram/ml 13 hours after quinine ingestion. Forced diuresis accounted for the removal of 557 mg of quinine in the first 5 hours and a total of 1625 mg over 75 hours., A 6 hour hemodialysis recovered 30 mg of quinine while peritoneal dialysis removed an average of 1.6 mg/hr over the first 48 hours. Plasmapheresis over 3 hours exchanged 2 liters of plasma containing a total of 8.5 mg of quinine. Some vision returned 19 hours after quinine ingestion but did not become normal until 5 1/2 months later. We conclude that, hemodialysis, peritoneal dialysis and plasma exchange made only a minor contribution to quinine elimination by comparison with renal excretion of quinine.
mesh_terms: D000328:Adult; D001766:Blindness / Q000139:chemically induced; D004231:Diuresis; D006801:Humans; D008297:Male; D010530:Peritoneal Dialysis; D010956:Plasmapheresis; D011803:Quinine / Q000378:metabolism / Q000506:poisoning*; D006435:Renal Dialysis; D014794:Visual Fields
chemical_list: D011803:Quinine