The efficacy of anthelmintics against Thysaniezia giardi in South Africa.
Two field cases of apparent inefficacy of albendazole against cestodes in lambs were investigated. In both farms Thysaniezia giardi was identified and 2 critical controlled trials were conducted to determine the efficacy of 5 anthelmintics against T. giardi. Albendazole dosed at 3,8 mg/kg or 7,6 mg/kg live mass, mebendazole at 15 mg/kg were totally ineffective against T. giardi. Treatment with resorantel at 65 mg/kg or niclosamide at 50 mg/kg however, caused expulsion of the strobilae within 16--24 hours after treatment and at autopsy, lambs were free of scoleces of T. giardi.
D015766:Albendazole; D000813:Anilides / Q000008:administration & dosage; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage*; D001562:Benzimidazoles / Q000008:administration & dosage; D002159:Cambendazole / Q000008:administration & dosage; D008463:Mebendazole / Q000008:administration & dosage; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D009534:Niclosamide / Q000008:administration & dosage; D012118:Resorcinols / Q000008:administration & dosage; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*
D000813:Anilides; D000871:Anthelmintics; D001562:Benzimidazoles; D012118:Resorcinols; D002159:Cambendazole; C000982:resorantel; D008463:Mebendazole; D009534:Niclosamide; D015766:Albendazole