Oscillation of the electrical potential of the frog skin under the effect of Li+: theoretical formulation.
A theoretical model of oscillation is proposed. It is based on the non-linearity introduced in the functioning of the active pump by the presence of lithium. Other plausible causes of oscillation are shown not to interfere in this case. The oscillation is of the local type. Synchronization between the local oscillators is not achieved by diffusional, but by electrical coupling. Numerical calculation shows that the model fits reasonably well to the experimental data.
D000818:Animals; D004848:Epithelium / Q000502:physiology; D008094:Lithium / Q000494:pharmacology*; D008433:Mathematics; D008564:Membrane Potentials / Q000187:drug effects; D008954:Models, Biological; D010539:Permeability; D011188:Potassium / Q000378:metabolism; D011898:Ranidae; D012867:Skin / Q000187:drug effects; D012879:Skin Physiological Phenomena; D012964:Sodium / Q000378:metabolism
D008094:Lithium; D012964:Sodium; D011188:Potassium