Loxapine as an alternative to phenothiazines in a case of oculocutaneous skin pigmentation.
The authors describe a patient with changes in oculocutaneous pigmentation that cleared after chlorpromazine was discontinued. They suggest that loxapine may be a suitable alternative to phenothiazines when skin pigmentation and ocular involvement occur, although the patient must be carefully monitored for ocular problems.
D002746:Chlorpromazine / Q000009:adverse effects* / Q000627:therapeutic use; D002908:Chronic Disease; D003989:Dibenzoxazepines / Q000627:therapeutic use*; D005127:Eye Color / Q000187:drug effects*; D006801:Humans; D008152:Loxapine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000139:chemically induced; D012559:Schizophrenia / Q000188:drug therapy*; D012880:Skin Pigmentation / Q000187:drug effects*
D003989:Dibenzoxazepines; D008152:Loxapine; D002746:Chlorpromazine