Early effects of inhaled Ca-DTPA on the rat lung.
Inhalation of calcium trisodium diethylenetriaminepentaacetate (Ca-DTPA) increases the removal of plutonium and other transuranics from the body. Data are required to determine possible biological effects from inhaled DTPA. Female rats were given a single or 12 daily, 2-4 h, inhalation exposures to aerosols of 10, 20 and 40% Ca-DTPA and the lungs were examined at 21 and 42 days following the last exposure. No pulmonary pathology was found from the single inhalation treatment with Ca-DTPA while only a slight, peripheral, histiocytosis was observed in the lungs of multiple-treated rats. There was no significant effect of DTPA treatments on body weight, lung weight, hematology or serum chemistry values.
D000818:Animals; D005260:Female; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008175:Lung Neoplasms / Q000139:chemically induced; D008206:Lymphatic Diseases / Q000139:chemically induced; D009374:Neoplasms, Experimental / Q000139:chemically induced; D004369:Pentetic Acid / Q000009:adverse effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D004369:Pentetic Acid