Association between the C3F-gene and essential hypertension.
1. The complement 3 (C3) phenotype distribution in 112 patients with essential hypertension was compared with the distribution of 316 normotensive control subjects. 2. A significant increased frequency of the C3F-gene was found among the patients (0.2637 vs 0.1721, P = 0.0031), indicating an association between the C3F-gene and essential hypertension. 3. The relative risk of essential hypertension was calculated to be 1.90 for C3F-positive individuals. 4. The association between the C3F-gene and essential hypertension was stronger among the untreated patients, where a relative risk of 3.89 was found for C3F-positive subjects. 5. A significant negative correlation was found between the C3F-positivity and the severity of the hypertensive disease estimated by eye group changes. This might be in accordance with a negative natural selection of C3F-positive hypertensive patients. 6. The study supports the hypothesis that immunogenetic factors may be of pathogenetic importance in essential hypertension.
D000293:Adolescent; D000328:Adult; D000368:Aged; D003176:Complement C3 / Q000235:genetics*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic
D003176:Complement C3