Prolactin and contact sensitivity.
Hypophysectomized (Hypo-X) rats did not develop contact dermatitis in response to dinitrochlorobenzene (DNCB). Syngeneic pituitary grafts placed under the kidney capsule or daily treatment with prolactin restored the DNCB-reactivity of Hypo-X animals. Combined treatment with other pituitary hormones was ineffective. Treatment of normal rats with a potent prolactin antagonist drug, bromocriptine, was as effective in inhibiting contact sensitivity as was hypophysectomy. These results indicate the contact sensitivity is a prolactin dependent reaction.
D000818:Animals; D001971:Bromocriptine / Q000627:therapeutic use; D002417:Cattle; D003877:Dermatitis, Contact / Q000209:etiology*; D004137:Dinitrochlorobenzene; D005260:Female; D006801:Humans; D007016:Hypophysectomy; D010902:Pituitary Gland / Q000637:transplantation; D011388:Prolactin / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344
D004137:Dinitrochlorobenzene; D001971:Bromocriptine; D011388:Prolactin