Modeling of middle molecules in clinical studies.
1. Peptides 7f and 7g may be irreversible metabolic and products generated into and confined in a volume approximating extracellular fluid. 2. The concentration profiles reported for 7a, 7b, and 7c suggest they are metabolic intermediates and that complex metabolic upsets are induced by dialysis resulting in marked sequential acceleration of generation and removal. These compounds cannot be modeled at present. 3. In steady state 7f and 7g might be described by the function G = KrC + KmC; while 7a, 7b, and 7c would likely require a more complex function such as G(C,beta) = KrC + KmC.
D006801:Humans; D007700:Kinetics; D008433:Mathematics; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D010455:Peptides / Q000378:metabolism; D014118:Toxins, Biological / Q000378:metabolism*; D014511:Uremia / Q000378:metabolism*
D010455:Peptides; D014118:Toxins, Biological; C026865:uremia middle molecule toxins