Cerebral cortex responds rapidly to thyroid hormones.
In rats subjected to thyroidectomy there was a two- to fourfold increase in cerebral cortex iodothyronine 5'-deiodinase activity within 24 hours. This increase was prevented by thyroxine replacement. The increased cortical 5'-deiodinase in chronically hypothyroid rats was normalized within 4 hours by a single intravenous injection of triiodothyronine. These results indicate that the adult central nervous system can give a very rapid biochemical response to thyroid hormone.
D000818:Animals; D002540:Cerebral Cortex / Q000201:enzymology*; D007453:Iodide Peroxidase / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D010544:Peroxidases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013965:Thyroidectomy; D013974:Thyroxine / Q000378:metabolism*; D013997:Time Factors; D014284:Triiodothyronine / Q000378:metabolism*; D014285:Triiodothyronine, Reverse / Q000378:metabolism
D014284:Triiodothyronine; D014285:Triiodothyronine, Reverse; D010544:Peroxidases; D007453:Iodide Peroxidase; D013974:Thyroxine