The effect of 2-n-propyl-3-dimethylamino-5,6-methylenedioxyindene on caffeine-induced contractures of skeletal muscle.
It has been previously postulated that 2-n-propyl-3-dimethylamino-5,6-methylenedioxyindene (pr-MDI) exhibits calcium antagonistic properties with an intracellular site of action. The present investigation further substantiates this hypothesis by providing evidence that pr-MDI inhibits caffeine-induced contractures (which are mediated by intracellular calcium) of the isolated rat hemidiaphragm skeletal muscle both in the presence and in the absence of extracellular calcium.
D000818:Animals; D002110:Caffeine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D066298:In Vitro Techniques; D007192:Indenes / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D051381:Rats
D007192:Indenes; D002110:Caffeine; C027983:2-n-propyl-3-dimethylamino-5,6-methylenedioxyindene; D002118:Calcium