Effect of manganese and copper interaction on behavior and biogenic amines in rats fed a 10% casein diet.
Manganese chloride (1 mg manganese/ml drinking water) and copper sulphate (250 mg copper/kg diet) were administered daily for 30 days to growing rats maintained on a 10% casein diet. Manganese in combination with copper produced impairment in the learning ability and memory of rats in either dietary group, with greater alterations in those receiving a 10% casein diet. Hyperactivation due to the combined effects of the metal ions was identical in both dietary groups. The behavioral aberrations were associated with a marked accumulation of Cu in the brain of rats receiving the 10% casein diet. Combined exposure of Mn and Cu also produced a greater elevation in the levels of dopamine (DA) and norepinephrine (NE) and a depression of 5-hydroxytryptamine (5-HT) in the brain of animals fed with a 10% casein diet compared to the animals receiving the 21% casein diet. Thus the animals receiving the 10% casein diet appear to be more vulnerable to the neurotoxic effects of a combined exposure to manganese and copper. However rats maintained on the 21% casein diet and receiving both manganese and copper showed almost identical changes to those observed after manganese administration alone.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism*; D003300:Copper / Q000494:pharmacology*; D004044:Dietary Proteins / Q000008:administration & dosage*; D004347:Drug Interactions; D007858:Learning / Q000187:drug effects; D008297:Male; D008345:Manganese / Q000494:pharmacology*; D008568:Memory / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D015032:Zinc / Q000378:metabolism
D002395:Catecholamines; D004044:Dietary Proteins; D008345:Manganese; D003300:Copper; D015032:Zinc; D002118:Calcium