Experimental in vivo cross-resistance of vinca alkaloid drugs.
In human therapy, an absence of cross-resistance has been observed between vincristine and vindesine in patients receiving polychemotherapy whilst, in our experimental in vivo studies, such a cross-resistance has been found between Vinca alkaloids. Further studies are required to explain this discrepancy.
D000818:Animals; D000970:Antineoplastic Agents; D004351:Drug Resistance; D007941:Leukemia P388 / Q000188:drug therapy; D008297:Male; D051379:Mice; D014747:Vinblastine / Q000031:analogs & derivatives / Q000494:pharmacology; D014748:Vinca Alkaloids / Q000494:pharmacology*; D014750:Vincristine / Q000494:pharmacology; D014751:Vindesine; D000077235:Vinorelbine
D000970:Antineoplastic Agents; D014748:Vinca Alkaloids; D014750:Vincristine; D014747:Vinblastine; D000077235:Vinorelbine; D014751:Vindesine