[Histological study of the action of propranolol on the genital tract of the male rat].
Increasing doses of propranolol were injected intraperitoneally to four series of adult male rats in order to study the effect of this beta-blocking agent on various organs (testis, epididymis, prostate and seminal vesicle) and endocrine glands (adrenals, pancreas, thyroid, pituitary). Histological damage was observed only in testes: i.e., necrosis and desquamation of germinal cells in the seminiferous tubules associated with light arterial vasoconstriction. Pelviperitoneal fibrosis was observed as well. These lesions seem to be of pharmacological vascular origin and appear to occur in combination with an elective toxic effect of propranolol on the germinal cells.
D000818:Animals; D004822:Epididymis / Q000033:anatomy & histology / Q000187:drug effects; D005837:Genitalia, Male / Q000187:drug effects*; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D011467:Prostate / Q000033:anatomy & histology / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects
D011433:Propranolol
Etude histologique de l'action du propranolol sur l'appareil génital du rat mâle.