[Pharmacological analysis of a disorder in the mechanisms of coronary vessel reactivity in an experimental model of coronary insufficiency].
In stimulation of the heart work with inadequate perfusion, the reactivity of coronary vessels is often disturbed which is revealed by the enhancement of extravascular contraction or by the absence of an adequate vasodilatation. The analysis of disturbance mechanisms in the reactivity of coronary vessels has been carried out with the aid of two groups of pharmacologic substances, one exercising a dilatating effect on the coronary vessels and the other affecting the calcium metabolism. One group included adenosine and verapamil (as antagonists of the action of calcium) as well as etmozine-blocker of the sodium channels capable of affecting the level of Ca+2 through Na-Ca metabolism; the other group included caffeine, calcium chloride, norepinephrine. The results suggest that adaptive reactions of the coronary vessels are closely connected with the calcium metabolism in smooth muscles of the vascular wall. Hence, while using vasodilators to treat coronary insufficiency, the approach to a selection of drugs with different effects on electro-mechanical conjunction in smooth muscles of vascular wall should be differentiated.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology; D003327:Coronary Disease / Q000503:physiopathology*; D003331:Coronary Vessels / Q000187:drug effects*; D004195:Disease Models, Animal; D004285:Dogs; D066298:In Vitro Techniques; D009129:Muscle Tonus / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D014665:Vasodilator Agents; D002118:Calcium
Farmakologicheskiĭ analiz narusheniia mekhanizmov reaktivnosti koronarnykh sosudov na éksperimental'noĭ modeli koronarnoiĭ nedostatochnosti.