[Kanamycin sulfate and sodium cephazolin pharmacokinetics in experimental strangulation obstruction of the small intestine].
The experimental investigation of pharmacokinetic properties of kanamycin and cephazolin has shown the antibiotic to penetrate well into the blood, lymph, abdominal exudate. Transport of kanamycin in the wall of the strangulated intestine and its mesentery through the lymphatic system and by adsorption from the abdominal exudate is supposed to be possible. Normal concentration of the antibiotic was determined in the tissues around the strangulation zone. The concentration peak of both antibiotics was noted 1 hour after introduction in all the biosubstrates studied which may serve as an orientator for the optimal time of operation.
D000818:Animals; D002437:Cefazolin / Q000378:metabolism*; D004285:Dogs; D005260:Female; D007273:Injections, Intramuscular; D007415:Intestinal Obstruction / Q000150:complications / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism*; D007612:Kanamycin / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D011300:Preoperative Care; D013997:Time Factors; D014018:Tissue Distribution
D007612:Kanamycin; D002437:Cefazolin
Farmakokinetika kanamitsina sul'fata i tsefazolina natriia pri éksperimental'noĭ stranguliatsionnoĭ tonkokishechnoĭ neprokhodimosti.