title: Pharmacokinetic evaluation of betamethasone and its water soluble phosphate ester in humans.
abstract: Two betamethasone tablet formulations, and betamethasone phosphate solution were compared in a plasma level study. The tablet formulations (A and B) and a solution of betamethasone phosphate (C) were administered in single 2 mg doses to nine volunteers according to a three times repeated Latin square design. Plasma samples were obtained over 72 h following each dose and plasma was analysed for betamethasone by radioimmunoassay. Pharmacokinetic evaluation of the data, obtained according to the one-compartment open model, indicated that there were no significant differences between the extent of absorption, and the first-order elimination rate constants. As would be expected, the solution (C) gave a faster absorption rate than tablets A and B.
mesh_terms: D000328:Adult; D001623:Betamethasone / Q000031:analogs & derivatives* / Q000378:metabolism*; D001682:Biological Availability; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D012995:Solubility; D013607:Tablets
chemical_list: D013607:Tablets; C028994:betamethasone sodium phosphate; D001623:Betamethasone