Treatment of giardiasis: relative efficacy of metronidazole as compared with tinidazole.
50 patients with giardiasis were treated with either metronidazole or tinidazole in random order according to a code. 25 patients received 2.0 g metronidazole on 2 consecutive days; 19 were cured (76%); 7 patients complained of mild side-effects. 25 patients received tinidazole 2.0 g as a single dose, and 22 were cured (88%); 5 patients complained of mild side-effects. The difference between the results of the two regimens was not statistically significant. A 1-week course of metronidazole (200 mg 3 times daily) was successful in 8/9 failures; 1 patient was finally cured with mepacrine.
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005873:Giardiasis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D009593:Nitroimidazoles / Q000627:therapeutic use*; D014011:Tinidazole / Q000009:adverse effects / Q000627:therapeutic use*
D009593:Nitroimidazoles; D014011:Tinidazole; D008795:Metronidazole