title: [Effect of GABA isonicotinoylamide on cerebral circulation].
abstract: It was found that isonicotinoylamide GABA intensifies cerebral circulation and decreases the tone of the cerebral vessels in both arterial systems of the brain. This effect was more pronounced in conscious cats than in anesthetized animals. Isonicotinoylamide GABA was shown to produce the central depressant action on the nervous control of cerebral circulation. The drug considerably depressed the reflex changes in the tone of the cerebral vessels and those in the cerebral blood flow, as well as tonic and reflex activity in the sympathetic nerves.
mesh_terms: D000818:Animals; D002415:Cats; D002536:Cerebral Arteries / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D007539:Isonicotinic Acids / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D007539:Isonicotinic Acids; D005680:gamma-Aminobutyric Acid; C016823:isonicotinylamide GABA
vernacular_title: Vliianie izonikotinoilamida GAMK na mozgovoe krovoobrashchenie.