Hematuria preceding renal calculus formation in children with hypercalciuria.
Five children were evaluated for painless hematuria; currently recommended diagnostic studies were unsuccessful in determining a diagnosis. A renal calculus subsequently was passed or detected radiographically in each child from 14 to 20 months after the initial evaluation. Hypercalciuria was then demonstrated by quantitation of 24-hour urinary calcium excretion or by measurement of urinary calcium/creatinine ratio. Calculi and hematuria have not recurred following thiazide therapy. We infer that idiopathic hypercalciuria was a probable cause of the unexplained painless hematuria.
D002118:Calcium / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000652:urine; D005260:Female; D006417:Hematuria / Q000209:etiology*; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D007223:Infant; D007669:Kidney Calculi / Q000150:complications* / Q000517:prevention & control; D008297:Male
D006852:Hydrochlorothiazide; D003404:Creatinine; D002118:Calcium