Transfer of Salbutamol in the human placenta in vitro.
The maternal-fetal transfer of Salbutamol was studied in vitro, in dual perfusion of isolated human placental lobules. The fraction of drug transferred to the fetal side was compared to reference substances:((14)C)-antipyrine and ((3H)-inulin. Salbutamol transfer (12%) represents about 39% of antipyrine and five times of inulin transfer. Studies with varying Salbutamol concentrations in the maternal arterial perfusate revealed that the drug transfer to the fetal side was effected by a flow-dependent diffusion process. We conclude that the reported effects on the fetus following a maternal drug infusion are mediated by the drug transferred across the placenta.
D000420:Albuterol / Q000378:metabolism*; D000983:Antipyrine / Q000378:metabolism; D001692:Biological Transport; D004058:Diffusion; D005260:Female; D006801:Humans; D007444:Inulin / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D010477:Perfusion; D010920:Placenta / Q000502:physiology*; D049590:Postpartum Period; D011247:Pregnancy; D014471:Umbilical Veins
D007444:Inulin; D000420:Albuterol; D000983:Antipyrine