Tolerance to corticoids? Guinea pig epithelium as an experimental system.
The antiacanthogenic effect of topical applied steroids is well known and maybe exactly assessed and quantified by means of the test procedure described. A 0.1% clobetasol-17-propionate solution induces an antiacanthogenic effect of 27.5% after a 28-day treatment period. After 84 days, the skin further treated with the corticosteroid shows an antiacanthogenic effect of 23.7% and after 118 days of 39%. A steroid tolerance of epithelial layer on guinea pig skin cannot be derived from our results.
D000818:Animals; D001623:Betamethasone / Q000031:analogs & derivatives*; D002990:Clobetasol / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D004848:Epithelium / Q000187:drug effects; D006168:Guinea Pigs; D012867:Skin / Q000187:drug effects*; D012880:Skin Pigmentation / Q000187:drug effects
D001623:Betamethasone; D002990:Clobetasol