Kinetics of drug decomposition. Part 67. Kinetics of degradation of dicloxacillin in aqueous solution.
The rates of hydrolysis of beta-lactam ring of dicloxacillin (DC) in the pH range 1.10-9.65 at 293, 303 and 313 K were determined. Specific rate constants were calculated for: H degree ions, undissociated phosphoric acid and H2PO4- ions catalysis of hydrolysis of undissociated DC molecule; for H+, OH-, HPO4(-2) and CH3COO- ions and undissociated phosphoric and acetic acids catalysis of hydrolysis of dissociated DC species and spontaneous hydrolysis of dissociated DC species. For each process the thermodynamic parameters were determined.
D004009:Dicloxacillin; D004355:Drug Stability; D007700:Kinetics; D012996:Solutions; D013816:Thermodynamics
D012996:Solutions; D004009:Dicloxacillin