The effects of oral acebutolol and propranolol on forearm blood flow in hypertensive patients.
1 Nine hypertensive patients received by mouth daily doses of 400 mg of acebutolol and then, after a 2 week washout period, 80 mg of propranolol for 2 week periods in an open study. 2 Both treatments caused equivalent cardiac blockade as assessed by reduction in exercise tachycardia. 3 Both treatments lowered blood pressure, although this effect on pressure was better maintained in the case of acebutolol. 4 Forearm blood flow, at rest, was significantly reduced at 2 h after dosing with propranolol, but not after acebutolol. 5 This difference between the two drugs is probably due to the cardioselectivity of orally administered acebutolol in man.
D000070:Acebutolol / Q000097:blood / Q000494:pharmacology*; D000284:Administration, Oral; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005542:Forearm / Q000098:blood supply*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D011433:Propranolol / Q000097:blood / Q000494:pharmacology*; D012039:Regional Blood Flow; D014655:Vascular Resistance / Q000187:drug effects
D000070:Acebutolol; D011433:Propranolol