Histology of the rat vas deferens after injection of a non-occlusive chemical contraceptive.
An alternate co-polymer of styrene and maleic anhydride was dissolved in dimethylsulphoxide and injected into the vas deferens of rats. The polymer was retained in the vas deferens and the morphological changes detected were confined to the mucosa. When the polymer was removed by flushing dimethylsulphoxide, the mucosal structure became normal within 2 weeks.
D000818:Animals; D003272:Contraceptive Agents, Male / Q000494:pharmacology*; D005663:Furans / Q000494:pharmacology*; D008297:Male; D008299:Maleic Anhydrides / Q000494:pharmacology*; D011137:Polystyrenes / Q000494:pharmacology*; D051381:Rats; D014649:Vas Deferens / Q000187:drug effects* / Q000473:pathology
D003272:Contraceptive Agents, Male; D005663:Furans; D008299:Maleic Anhydrides; D011137:Polystyrenes; C025704:Styromal