Alterations of host resistance to Listeria monocytogenes in tumour-bearing mice and the effect of Corynebacterium parvum.
In tumour (fibrosarcoma)-inoculated mice, alterations of host resistance to Listeria monocytogenes following tumour growth were examined. Non-immune macrophage-mediated antibacterial resistance was severely suppressed up to day 4 or so after tumour inoculation, but was enhanced thereafter. On the other hand, T cell-mediated immune resistance retained the control level up to day 7 or so, but was suppressed thereafter. Suppression of macrophage-mediated antibacterial resistance was not observed if the tumour-bearing mice had been pretreated with Corynebacterium parvum. Moreover, this suppression of macrophage-mediated resistance was attributable to the presence of a serum factor that interferes with the function of free macrophages but not with that of resident macrophages. The ability of this serum factor to suppress macrophage-mediated antibacterial resistance, however, was not reduced by C. parvum administration.
D000818:Animals; D005354:Fibrosarcoma / Q000276:immunology*; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007113:Immunity, Innate; D007165:Immunosuppression Therapy; D008088:Listeriosis / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D011425:Propionibacterium acnes / Q000276:immunology*