Inhibition of dihydropteridine reductase by dopamine.
Dihydropteridine reductase has been purified 900-fold from rat liver. Dopamine inhibited the enzyme up to 50% at a concentration of 0.11mm. In the presence of dopamine the enzyme gave non-hyperbolic v-against-[S] plots. This enzyme may have a role in control of dopamine biosynthesis.
D000818:Animals; D004093:Dihydropteridine Reductase / Q000037:antagonists & inhibitors*; D004298:Dopamine / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D008297:Male; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains
D004093:Dihydropteridine Reductase; D009247:NADH, NADPH Oxidoreductases; D004298:Dopamine