[Chromosome aberrations and molecular weight of single-stranded DNA fragments in embryonal fibroblasts of mouse strains 101/H and CBA].
Fibroblasts from 101/H mouse fetuses manifest a higher rate of spontaneous chromosome aberrations as compared to fibroblasts from CBA fetuses. The molecular weight of single-strand DNA fragments from 101/H mice was found to be lower than that in CBA mice. No differences were disclosed in the strength of the DNA-protein bond in the cell chromatin of both mouse strains. It is assumed that the alkaline-labile-sites in DNA may be the cause of chromosome aberrations. The possibility of using 101/H mice as a model of human chromosomal instability syndromes is discussed.
D000818:Animals; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D002869:Chromosome Aberrations; D004277:DNA, Single-Stranded / Q000032:analysis*; D003852:Deoxyribonucleoproteins / Q000032:analysis*; D005347:Fibroblasts; D051379:Mice; D008808:Mice, Inbred CBA / Q000196:embryology; D008815:Mice, Inbred Strains / Q000196:embryology; D008970:Molecular Weight; D009698:Nucleoproteins / Q000032:analysis*; D013045:Species Specificity
D004277:DNA, Single-Stranded; D003852:Deoxyribonucleoproteins; D009698:Nucleoproteins
Khromosomnye aberratsii i molekuliarnaia massa odnonitevykh fragmentov DNK v émbrional'nykh fibroblastakh mysheĭ linii 101/H i CBA.