Effects of nandrolone decanoate on the toxicity and anti-tumour action of CCNU and FU in murine tumours.
Pre-treatment with the anabolic steroid nandrolone decanoate (ND) increases the LD50 of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 5-Fluorouracil (FU) in NMRI mice. Administration of ND did not affect the anti-tumour action of CCNU against a transplantable mouse adenocarcinoma of the colon (MAC 13) or the anti-tumour action of FU against MAC 26. In both tumour lines ND had no significant effect on tumour growth. These data suggest that an increase in the anti-tumour selectivity of these agents may be produced by pre-treatment with ND.
D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use* / Q000633:toxicity; D007928:Lethal Dose 50; D007958:Leukocyte Count; D008130:Lomustine / Q000627:therapeutic use* / Q000633:toxicity; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000077603:Nandrolone Decanoate; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009607:Nitrosourea Compounds / Q000627:therapeutic use*
D009607:Nitrosourea Compounds; D009277:Nandrolone; D008130:Lomustine; D000077603:Nandrolone Decanoate; D005472:Fluorouracil