S-adenosylmethionine synthetase isozymes in the liver of tumor-bearing mice.
Isozyme patterns of S-adenosylmethionine synthetase have been determined with and without dimethylsulfoxide in liver of tumor-bearing mice. The activity of the beta-form markedly increased following intraperitoneal transplantation of Ehrlich ascites tumor cells, whereas the activity of the alpha-form did not change so strikingly. Tumor cells were shown to have only the gamma-form of the enzyme. When the ascites fluid, after removing tumor cells, was injected into a normal mouse, the activity of the beta-form increased over that of control animals.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000201:enzymology*; D002850:Chromatography, Gel; D003600:Cytosol / Q000201:enzymology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008297:Male; D008716:Methionine Adenosyltransferase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051379:Mice; D009368:Neoplasm Transplantation; D014166:Transferases / Q000378:metabolism*
D007527:Isoenzymes; D014166:Transferases; D008716:Methionine Adenosyltransferase; D004121:Dimethyl Sulfoxide