Prevention of lactic acidosis in cattle by lasalocid or monensin.
Intraruminal administration of lasalocid or monensin (1.3 mg/kg body weight) effectively prevented in glucose- or corn-induced lactic acidosis in cattle. Administering the antibiotics for 7 days before experimentally inducing acidosis with corn (27.5 g/kg body weight), effectively prevented acidosis,  while 2 days' were sufficient to prevent glucose-induced acidosis (12.5 g/kg body weight). The different responses observed in the two trials probably stemmed from the difference in amounts of carbohydrate used to induce acidosis. Antibiotic-treated cattle had higher rumen pH values and lower L(+) and D(-) lactate concentrations that control cattle that received no antibiotics. Ruminal VFA in control cattle decreased, while total VFA and the molar proportion of propionate increased in antibiotic-treated cattle after grain engorgement. Control cattle exhibited classic signs of acidosis, such as lowered blood pH; increased blood lactate, particularly D(-) isomer; hemoconcentration, and depleted alkali reserve with a pronounced based deficit. Antibiotic-treated cattle exhibited no signs of systemic acidosis.
D000138:Acidosis / Q000378:metabolism / Q000517:prevention & control / Q000662:veterinary*; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000378:metabolism / Q000517:prevention & control*; D005663:Furans / Q000627:therapeutic use*; D006863:Hydrogen-Ion Concentration; D007773:Lactates; D007832:Lasalocid / Q000627:therapeutic use*; D008297:Male; D008985:Monensin / Q000627:therapeutic use*; D012417:Rumen / Q000378:metabolism
D005663:Furans; D007773:Lactates; D008985:Monensin; D007832:Lasalocid