Hypercalcaemia in alphacalcidol therapy.
Three women with hypoparathyroidism are described who developed severe symptomatic hypercalcaemia while being treated with alphacalcidol (1 alpha-hydroxycholecalciferol; One-Alpha). One sustained permanent renal damage. Alphacalcidol may have advantages over calciferol in its speed of action but poisoning may be more likely to occur. Frequent follow-up checks on the plasma calcium is needed for any patient on alphacalcidol. For long-term management calciferol may still be the drug of choice.
D000328:Adult; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000009:adverse effects*; D006934:Hypercalcemia / Q000139:chemically induced*; D007011:Hypoparathyroidism / Q000188:drug therapy
D006887:Hydroxycholecalciferols; C008088:alfacalcidol