Toxicity of middle molecules: clinical evaluation using a selective filtration artificial kidney.
The effect of four uremic patients, treated 4-6 months with a new artificial kidney system aimed to remove molecules between 10,000-40,000 daltons returning substances with mol wt 200-10,000 back to the patients, was compared with the effect of conventional hemodialysis. The patients treated with this system obtained a more stable hemoglobin concentration without blood transfusions. They got an increased mean nerve conduction velocity and their plasma increased in quality as culture medium on human mononuclear phagocytes grown in vitro.
D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003404:Creatinine / Q000378:metabolism; D006801:Humans; D007688:Kidneys, Artificial; D010586:Phagocytes / Q000187:drug effects / Q000502:physiology*; D006435:Renal Dialysis; D014118:Toxins, Biological / Q000097:blood* / Q000494:pharmacology; D014508:Urea / Q000378:metabolism; D014511:Uremia / Q000628:therapy*
D014118:Toxins, Biological; C026865:uremia middle molecule toxins; D014508:Urea; D003404:Creatinine