[Demonstration of latent postural asymmetry by means of a synthetic hexapeptide].
In experiments on random-bred rats, the synthetic hexapeptide Tyr-Gly-Gly-Phe-Leu-Arg caused the intensification of the muscle tone in the latent period of formation of the generator of pathologically enhanced excitation and in the stage where the generator activity did not manifest under normal conditions (clinical recovery). The effect described was shown both clinically by extension of the hind leg and electromyographically by the appearance of asynchronous electrical activity in the muscles of the hind leg. Control suboccipital administration of the related hexapeptide not containing D-leucin, or physiological solution did not produce the effect described.
D000818:Animals; D004723:Endorphins; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives*; D004745:Enkephalins; D009127:Muscle Rigidity / Q000139:chemically induced / Q000503:physiopathology*; D009132:Muscles / Q000503:physiopathology*; D011187:Posture; D051381:Rats; D013118:Spinal Cord Diseases / Q000139:chemically induced / Q000503:physiopathology*; D013744:Tetanus Toxin
D004723:Endorphins; D004745:Enkephalins; D013744:Tetanus Toxin; D004743:Enkephalin, Leucine; C026768:enkephalin-Leu, Arg(6)-
Vyiavlenie skrytoĭ poznoĭ asimmetrii s pomoshch'iu sinteticheskogo geksapeptida.