[Effect of stimulation of the paleocerebellar cortex on the multifocal cortical epileptogenic complex].
Effects of paleocortex electrical stimulation on multifocal epileptic complex of the brain cortex alone and in combination with benzodiazepines (diazepam, phenazepam) were investigated in experiments on cats. The animals developed complex reactions which included the increased frequency of seizure potentials during stimulation, their suppression after the cessation of stimulation and the postsuppression rise of frequency (dyssuppression). This points to the dualistic character of cerebellar effects on the brain cortex. On being administered before stimulation benzo-diazepines significantly changed the above effects: activation and dyssuppression first disappeared, whereas the suppression of the epileptic activity in the brain cortex remained unchanged.
D000818:Animals; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants / Q000627:therapeutic use; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000627:therapeutic use; D002415:Cats; D002525:Cerebellar Cortex / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D003975:Diazepam / Q000627:therapeutic use; D004558:Electric Stimulation; D004594:Electrophysiology; D010406:Penicillins; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001570:Benzodiazepinones; D010406:Penicillins; D001569:Benzodiazepines; C017928:phenazepam; D003975:Diazepam
Vliianie stimuliatsii paleotserebelliarnoĭ kory na mnogoochagovyĭ korkovyĭ épilepticheskiĭ kompleks.