[Effect of serotonin and its antagonists on bladder detrusor function].
In anesthetized dogs, intravenous administration of serotonin causes biphasic contraction of the urinary bladder followed by relaxation. The m-antagonist of serotonin, morphine inhibits the first phase of contraction but does not affect the second phase and relaxation. The T-antagonist tipindole exerts no effect on the serotonin-induced contraction and relaxation of the detrusor. The D-antagonists, LSD-25, dihydroergotamine, droperidol and cyproheptadine produce no effect on the first phase of contraction but inhibit the second one and successive relaxation of the urinary bladder detrusor. In addition to D-antagonists of serotonin, the relaxation of the detrusor is also suppressed by inderal and guanethidine which indicates the participation of the sympathetic component in the effect realization. The serotonin-induced relaxation of the detrusor is not suppressed by benzohexonium.
D000818:Animals; D003533:Cyproheptadine / Q000494:pharmacology; D004087:Dihydroergotamine / Q000494:pharmacology; D004285:Dogs; D004329:Droperidol / Q000494:pharmacology; D005260:Female; D006145:Guanethidine / Q000494:pharmacology; D006584:Hexamethonium Compounds / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009130:Muscle, Smooth / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D001743:Urinary Bladder / Q000187:drug effects*
D006584:Hexamethonium Compounds; D007211:Indoles; D012702:Serotonin Antagonists; D003533:Cyproheptadine; D012701:Serotonin; D004087:Dihydroergotamine; D009020:Morphine; D008238:Lysergic Acid Diethylamide; D011433:Propranolol; D004329:Droperidol; C013716:tipindole; C021628:benzohexonium; D006145:Guanethidine
Vliianie serotonina i ego antagonistov na funktsiiu detruzora mochevogo puzyria.