Protection by alpha-tocopherol and dimethylsulfoxide (DMSO) against adriamycin induced skin ulcers in the rat.
Extravasation of adriamycin during intravenous infusion to cancer patients can cause serious local complications. Topical application of 1 ml 10% alpha-tocopherol succinate in DMSO for 2 or 7 days produced up to a 71% decrease in the diameter of skin ulcers produced by intradermal adriamycin in the rat. A combination of alpha-tocopherol and DMSO might be useful for protecting humans against accidentally extravasated adriamycin.
D000287:Administration, Topical; D000818:Animals; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use*; D004317:Doxorubicin / Q000009:adverse effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012883:Skin Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D014810:Vitamin E / Q000627:therapeutic use*
D014810:Vitamin E; D004317:Doxorubicin; D004121:Dimethyl Sulfoxide