An in vitro study on the toxoplasmacidal activity of lonomycin A in host cells.
Lonomycin A at various concentrations was tested for its inhibitory effect on Toxoplasma multiplication in host cells cultured in vitro. Results indicate that lonomycin A at a concentration of 0.01 micrograms per ml in TC-199 medium demonstrated a high degree of antitoxoplasma activity with complete inhibition of Toxoplasma multiplication in the host cells. Lymphokines, a supernatant produced from spleen cells of mice infected chronically with Toxoplasma gondii, inhibited Toxoplasma multiplication in mice macrophage and kidney cell monolayers. However, lonomycin A inhibited completely Toxoplasma multiplication in non-specific cells, i.e. not only in mice macrophages and kidney cells but also in cells of human and other animal species.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002415:Cats; D002478:Cells, Cultured; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006801:Humans; D007668:Kidney; D008222:Lymphokines / Q000037:antagonists & inhibitors; D008264:Macrophages / Q000469:parasitology; D009550:Nigericin / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D013552:Swine; D014122:Toxoplasma / Q000187:drug effects* / Q000276:immunology; D014123:Toxoplasmosis / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D000981:Antiprotozoal Agents; D008222:Lymphokines; C012410:lonomycin; D009550:Nigericin