[Naloxone-dependent morphine reduction of excitatory responses of mollusk neurons to dopamine].
Morphine injection into the perfusate at a concentration of 1 x 10(-5) M rapidly and reversibly inhibits depolarizing rather than hyperpolarizing responses of Helix pomatia neurons induced by dopamine (1 x 10-5). The depressant effect of morphine is completely reversed by naloxon (1 x 10(-5) M). The results suggest the involvement of an opiate receptor mechanism. The dose-response curves for dopamine before morphine application and in its presence indicate a noncompetitive mechanism of interaction between morphine and dopamine.
D000818:Animals; D004298:Dopamine / Q000494:pharmacology; D018492:Dopamine Antagonists; D004305:Dose-Response Relationship, Drug; D005724:Ganglia / Q000187:drug effects*; D006372:Helix, Snails; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology
D018492:Dopamine Antagonists; D009270:Naloxone; D009020:Morphine; D004298:Dopamine
Naloksonzavisimoe oslablenie morfinom vozbuzhdaiushchikh otvetov neĭronov molliuskov na dofamin.