Concurrent occurrence of elevated ketone body and depressed carnitine level in underfed guinea-pigs.
Food ingestion of male guinea-pigs was restricted to 10 g/day. Total carnitine content of liver of the underfed animals fell to 3.75 mumoles per liver (46.1% of control). Serum level of total carnitine was 35.0 nmoles/ml (64.4%) in the underfed animals while they developed high ketonemia, 384.2 nmoles/ml (555.2%). In "restricted' animals the carnitine levels also decreased in the muscles.
D000818:Animals; D002331:Carnitine / Q000097:blood / Q000378:metabolism*; D005508:Food Deprivation / Q000502:physiology*; D006168:Guinea Pigs; D007657:Ketone Bodies / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism
D007657:Ketone Bodies; D002331:Carnitine