Inhibition of mutagenesis in Chinese hamster V-79 cells by antioxidants.
The mutagenicity of benzo(a)pyrene (BP) on Chinese hamster V-79 cells cocultivated with X-irradiated hamster embryo cells was inhibited by phenolic antioxidants, such as tert-butyl-4-hydroxyanisole (BHA) and butyl-hydroxytoluene (BHT), but not by disulfiram and its related compounds such as tetraethylthiuram disulfide, diethyldithiocarbamic acid and dimethyldithiocarbamic acid. The mutagenicity of BP on V-79 cells was reduced 44% by BHA and 25% by BHT. BHA inhibited BP-induced mutagenesis, but not N-acetoxy-2-acetylaminofluorene (N-acetoxy-AAF)-induced mutagenesis. BHA is suggested to inhibit the mutagenic action of BP by altering its metabolism.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001580:Benzopyrenes / Q000037:antagonists & inhibitors; D001711:Biotransformation; D006224:Cricetinae; D003412:Cricetulus; D009153:Mutagens / Q000378:metabolism; D009154:Mutation; D010636:Phenols / Q000494:pharmacology
D000975:Antioxidants; D001580:Benzopyrenes; D009153:Mutagens; D010636:Phenols