[Granulocytic function in children with selective IGA deficiency and recurrent infections: demonstration of altered chemotaxis].
Some parameters of neutrophil function (NBT reduction, bactericidal activity, chemotaxis) have been examined in 15 children with selective IgA deficiency and recurrent infections of respiratory and/or intestinal tract. In no case a defect in NBT reduction was observed. Mean results of bactericidal activity were normal, but in one child bacterial killing was lower than 2 SD of normal values. In 7 out 12 of patients a severe defect in cellular chemotaxis was proved, and in 1 a poor chemotactic activity of the serum was observed. Correlations between the defect in neutrophil chemotaxis and selective IgA deficiency are discussed.
D001770:Blood Bactericidal Activity; D002634:Chemotaxis, Leukocyte; D002648:Child; D002675:Child, Preschool; D004406:Dysgammaglobulinemia / Q000150:complications*; D005260:Female; D005759:Gastroenteritis / Q000209:etiology*; D006098:Granulocytes; D006801:Humans; D017098:IgA Deficiency; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D009504:Neutrophils; D009580:Nitroblue Tetrazolium; D012141:Respiratory Tract Infections / Q000209:etiology*; D012397:Rosette Formation
D009580:Nitroblue Tetrazolium
La funzione granulocitaria in bambini con deficit selettivo di IgA ed infezioni ricorrenti: dimostrazione di un'alterata chemiotassi.