[8-Methoxypsoralen (8-MOP)-a new galenic form and its relation to 8-MOP serum levels (author's transl)].
A bioequivalence study was performed with two different 8-MOP preparations. Thirty-eight patients participated in the investigation. We compared a product already marketed containing a micronized powder in hard gelatine capsules with a new product in soft gelatine capsules containing the 8-MOP in a solution. With the new galenic preparation the serum level obtained was 3.2 (P less than or equal to 0.01) times higher than with the old product. Thus, the improved resorption out of the solution was mainly responsible for these results.
D004304:Dosage Forms; D006801:Humans; D008730:Methoxsalen / Q000008:administration & dosage* / Q000097:blood; D011701:PUVA Therapy; D010778:Photochemotherapy; D011565:Psoriasis / Q000188:drug therapy*; D013810:Therapeutic Equivalency
D004304:Dosage Forms; D008730:Methoxsalen
8-Methoxypsoralen (8-MOP) in neuer galenischer Zubereitung und seine Beziehung zum 8-MOP-Serumspiegel.