[Suppressant effect of oxyfedrine on development of anaphylaxis in experimental animals].
Oxyfedrine (ildamen) which stimulates beta-adrenoreceptors of smooth muscles in concentrations increasing the tissue content of cAMP produced a dose-dependent inhibition of anaphylactic bronchospasm and contractions of the guinea-pig intestine induced by administration of ovalbumin. The results obtained provide evidence in favour of oxyfedrine use for suppression of immediate type allergic reactions with the involvement of smooth muscles.
D000707:Anaphylaxis / Q000188:drug therapy* / Q000503:physiopathology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007422:Intestines; D008297:Male; D009130:Muscle, Smooth / Q000503:physiopathology; D010099:Oxyfedrine / Q000627:therapeutic use*; D011427:Propiophenones / Q000627:therapeutic use*
D011427:Propiophenones; D010099:Oxyfedrine
Podavliuiushchee deĭstvie oksifedrina na razvitie anafilaksii u éksperimental'nykh zhivotnykh.