[Polychemotherapy using carminomycin in the combined treatment of the disseminated form of Ewing's sarcoma in children].
The results of the treatment of the prevalent form of Ewing's sarcoma in 85 children aged 3 to 16 years with various methods are presented. 21 patients were subjected to monochemotherapy with sarcolysine or cyclophosphamide. 26 patients received monochemotherapy with sarcolysine or cyclophosphamide in combination with irradiation of the metastases. Polychemotherapy in combination with radiotherapy was applied to 38 patients. The polychemotherapy in combination with radiotherapy was applied to 38 patients. The polychemotherapy included cyclophosphamide, vincristine, methotrexate, dactinomycin and carminomycin used in various combinations. The schemes of the polychemotherapy are presented. The best results were obtained with the use of the polychemotherapy in combination with radiotherapy: the index of the 3-year survival amounted to 38.5+/-14 per cent, while in the patients subjected to the monochemotherapy in combination with irradiation of the metastases it was equal to 3.8+/-3.7 per cent. After the monochemotherapy used alone all the children died by the 2nd year. It is concluded that patients with the prevalent form of Ewing's sarcoma should b subjected to systematic treatment. Polychemotherapy in combination with radiotherapy is shown to be promising.
D000293:Adolescent; D002360:Carubicin / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000008:administration & dosage; D003630:Daunorubicin / Q000031:analogs & derivatives*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006801:Humans; D008558:Melphalan / Q000008:administration & dosage; D009362:Neoplasm Metastasis; D011879:Radiotherapy Dosage; D012512:Sarcoma, Ewing / Q000401:mortality / Q000628:therapy*
D003520:Cyclophosphamide; D002360:Carubicin; D008558:Melphalan; D003630:Daunorubicin
Polikhimioterapiia s ispol'zovaniem karminomitsina v kombinirovannom lechenii rasprostranennoĭ formy sarkomy Iuinga u deteì.