Serotonin uptake in blood platelets of psychiatric patients.
Platelet serotonin (5-HT) uptake was determined in 72 newly admitted, unmedicated psychiatric patients. Decreased maximum velocity (Vmax) of 5-HT uptake was present in unipolar and bipolar depressed patients as well as schizoaffective depressed patients. The apparent Michaelis constant (km) of 5-HT uptake was normal in these groups, as was Vmax and Km in manic-depressive and chronic schizophrenic patients. Treatment of depressed patients with notriptyline hydrochloride or imipramine hydrochloride increased Km significantly. There was a trend for the increase in Km in the nortriptyline-treated patients to correlate with clinical improvement. Decreased 5-HT uptake in platelets provides additional evidence for the role of 5-HT in the pathophysiologic process of some forms of depression.
D000328:Adult; D000704:Analysis of Variance; D001714:Bipolar Disorder / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism; D002250:Carbon Radioisotopes; D003866:Depressive Disorder / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D009661:Nortriptyline / Q000494:pharmacology; D011618:Psychotic Disorders / Q000097:blood*; D012559:Schizophrenia / Q000097:blood; D012701:Serotonin / Q000097:blood*
D002250:Carbon Radioisotopes; D012701:Serotonin; D009661:Nortriptyline