[Effect of graded muscular exercise on the morphofunctional characteristics of the adrenal glands of dogs in experimental hypocorticism].
Morphological and functional equivalents of the adrenal response to repeated intramuscular injections of chloditan (o,p'-DDD) at a dose of 25 mg/kg in maize oil solution were studied in 29 mongrel male dogs. In the presence of evident glucocorticoid function inhibition (according to the control of 17-HOCS biochemical findings in the urine), the animals ran every day on the treadmill up to 3B and 4th stages of the organism response (according to the cardiovascular and respiratory system parameters, obtained in the running process). The maximum number of o,p'-DDD injections per animal was 40 and that of exercises 31. On the basis of morphometric, histological, histochemical and electron microscopic methods the optimizing effect of the motor activity on the adrenal structure under conditions of the glucocorticoid function inhibition was shown. Optimum of such effect is within the limits of the running up to stage 3B. The adrenal zones manifest different effects, concerning both the character and intensity of the reaction, upon chloditan administration and quantitatively various motor activities.
D000311:Adrenal Glands / Q000503:physiopathology* / Q000648:ultrastructure; D000309:Adrenal Insufficiency / Q000139:chemically induced / Q000503:physiopathology*; D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D004285:Dogs; D007620:Karyometry; D008297:Male; D008939:Mitotane / Q000009:adverse effects; D005082:Physical Exertion
D008939:Mitotane
Vliianie dozirovannoĭ myshechnoĭ nagruzki na morfofunktsional'nuiu kharakteristiku nadpochechnikov sobak s éksperimental'nym gipokortitsizmom.