Enzyme activities of tryptophan metabolism in heterozygous and homozygous Gunn rats before and after blue light exposure.
The effect of light exposure in the enzyme activities, involved in the tryptophan metabolism along the kynurenine pathway, has been studied in male and female adult hetero-and homozygous Gunn rats. Light exposure did not seem to influence these enzyme activities. The groups of non-icteric heterozygotes however showed a higher activity of liver tryptophan pyrrolase than in the groups of icteric homozygotes. Kynureninase activity was similar in all the groups of rats, whereas liver kynurenine aminotransferase activity appeared slightly higher in the groups of male rats with respect to female rats, but no difference existed before and after irradiation. In addition the male heterozygotes showed a higher kynurenine aminotransferase activity in kidneys than the other groups of rats.
D000818:Animals; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006867:Hydrolases / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology; D007737:Kynurenine / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008190:Lyases; D008297:Male; D010775:Photic Stimulation; D051381:Rats; D011911:Rats, Gunn / Q000235:genetics / Q000378:metabolism*; D011922:Rats, Mutant Strains / Q000378:metabolism*; D000637:Transaminases / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism*; D014366:Tryptophan Oxygenase / Q000378:metabolism*
D007737:Kynurenine; D014364:Tryptophan; D014366:Tryptophan Oxygenase; D000637:Transaminases; C427605:glutamine - phenylpyruvate transaminase; C021481:kynurenine-oxoglutarate transaminase; D006867:Hydrolases; C021480:kynureninase; D008190:Lyases