[Effects of mecamylamine and pempidine, secondary and tertiary amines, on the spinal reflex of cats (author's transl)].
The ganglionic blocking effects of the secondary and tertiary amines, mecamylamine and pempidine, on the spinal reflex of cats of both sexes were investigated. These blocking effects were then compared with findings in the quaternary ammonium compounds such as tetraethylammonium (TEA) and decamethonium (C10). Mecamylamine (5 mg/kg) and pempidine (1 mg/kg) inhibited spinal reflex potentials such as the monosynaptic reflex (MSR), the polysynaptic reflex (PSR) and the dorsal root reflex (DRR). Maximal inhibition occurred 40 min after intravenous administration these drugs. In the case of mecamylamine, the inhibited potentials recovered gradually after reaching the maximum inhibition. However, the inhibitory effect of pempidine was prolonged, and recovery of the potentials did not occur for 6 min or longer. Although 10 mg/kg of C10 and 0.025 mg/kg of nicotine transiently inhibited the MSR and PSR, these compounds had no effect on the DDR. TEA produced prolonged inhibition of the MSR and PSR, and slightly enhanced the DRR. These results demonstrated the differences in DRR responses to secondary and tertiary amines, and quaternary ammoniums.
D000818:Animals; D002415:Cats; D003650:Decamethonium Compounds / Q000494:pharmacology; D003864:Depression, Chemical; D005260:Female; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology*; D009538:Nicotine / Q000494:pharmacology; D010393:Pempidine / Q000494:pharmacology*; D012023:Reflex, Monosynaptic / Q000187:drug effects*; D013116:Spinal Cord / Q000187:drug effects*; D013757:Tetraethylammonium Compounds / Q000494:pharmacology
D003650:Decamethonium Compounds; D013757:Tetraethylammonium Compounds; D008464:Mecamylamine; D009538:Nicotine; D010393:Pempidine