Plasma nomifensine concentration. Cardiological effects and clinical response.
Cardiological effects of nomifensine were studied in 10 endogenously depressed in-patients receiving up to 200 mg/day for 3 weeks. No significant cardiac effects were observed using His' bundle electrography and electrocardiography. 9 of the 10 patients showed a significant recovery from their depressive illness. Plasma nomifensine concentrations at day 22 were not correlated with clinical response, blood pressure, or electrocardiographic parameters. A negative correlation between A-H interval, in the His' bundle electrogram, and day 22 nomifensine concentration was observed.
D000293:Adolescent; D000328:Adult; D002036:Bundle of His / Q000187:drug effects; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy*; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects*; D006801:Humans; D007546:Isoquinolines / Q000097:blood* / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009627:Nomifensine / Q000097:blood* / Q000494:pharmacology* / Q000627:therapeutic use
D007546:Isoquinolines; D009627:Nomifensine