[Effects of glucocorticoids on the gastrointestinal tract of normal rats and rats deficient in endogenous prostaglandins].
Here are studied the effects of administration of prednisolone on intestinal tract of normal rats and of rats into which a lack of prostaglandins has been caused and shown. The appearance of ulcerative lesions of the same type and of the same size in both groups of the studied animals might lead us to believe that the ulcerative action of glucocorticoids, at least in some cases, may be independent from the production of prostaglandins and may thus be attributed to other mechanisms.
D000818:Animals; D004064:Digestive System / Q000187:drug effects* / Q000473:pathology; D005228:Fatty Acids, Essential / Q000172:deficiency*; D011239:Prednisolone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013929:Thromboxane B2 / Q000097:blood*; D013931:Thromboxanes / Q000097:blood*
D005228:Fatty Acids, Essential; D013931:Thromboxanes; D013929:Thromboxane B2; D011239:Prednisolone
Effetti dei glicocorticoidi sull'apparato gastro-enterico di ratti normali e di ratti carenti in prostaglandine endogene.