A case of fatal poisoning by rifampicin.
The toxicologic findings of a fatal poisoning with rifampicin (Rimactan) are presented. The concentration of rifampicin and its two major metabolites 25-desacetylrifampicin and 3-formylrifamycin in post-mortem blood, urine, bile and liver at about 10 h after ingestion of 14-15 g was determined using a high-performance liquid chromatographic method. The results of the toxicological analyses were compared with findings in fatal and non-fatal intoxications and after therapeutic administration of the drug. Possible explanation for the fatal outcome is given.
D000328:Adult; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D012293:Rifampin / Q000378:metabolism / Q000506:poisoning*
D012293:Rifampin