Potent inhibition of thrombin by the newly synthesized arginine derivative No. 805. The importance of stereo-structure of its hydrophobic carboxamide portion.
D001120:Arginine / Q000031:analogs & derivatives; D001665:Binding Sites; D007700:Kinetics; D008722:Methods; D009904:Optical Rotation; D010875:Pipecolic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D013237:Stereoisomerism; D013449:Sulfonamides; D013917:Thrombin / Q000037:antagonists & inhibitors*
D010875:Pipecolic Acids; D013449:Sulfonamides; D001120:Arginine; D013917:Thrombin; C031942:argatroban