title: In vitro studies on optimum preparation of coagulum for surgery of renal calculi.
abstract: In renal calculus surgery, human dried fibrinogen produces a coagulum with a much greater tensile strength, stickiness deformability and extractability than cryoprecipitate, which produces a relatively weak and friable clot. A useful coagulum may be prepared at room temperature at any convenient time prior to use if a mixture of 19 ml human dried fibrinogen solution and 1 ml thrombin solution is used. If mixed in a single syringe and injected within 35 s through a butterfly needle into the renal pelvis, complete mixing of the solutions is guaranteed. By using this simple method, the unpredictability of the coagulum can now be eliminated and a strong and elastic clot can be produced.
mesh_terms: D001777:Blood Coagulation; D002118:Calcium / Q000494:pharmacology; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D066298:In Vitro Techniques; D007669:Kidney Calculi / Q000601:surgery*; D013696:Temperature; D013718:Tensile Strength; D013917:Thrombin / Q000032:analysis; D013997:Time Factors
chemical_list: D005340:Fibrinogen; D013917:Thrombin; D002118:Calcium