[Preliminary data on the different endothelial reaction to Con A at different levels of the arterial tree in rabbits and in Cynomolgus monkeys].
Delayed appearance of atherosclerotic lesions in cerebral arteries has been observed not only in man but also in monkeys and rabbits submitted to atherogenic diets. Previous observations of ours had shown a Con A positive reaction ("glycocalyx" or "surface coat") at the luminal surface and in the plasmalemmal vesicles of aortic endothelial cells of rabbits an other laboratory animals. The "surface coat" is now reputed the site of lipoproteinlipase activity whose importance in atherogenesis has recently been stressed. In our present observations, the endothelial cells Con A reactivity after Bernhard and Avrameas which was not previously studied in the cerebral arteries of rabbits and monkeys has resulted always lacking in this arterial district. Those observations may help explaining delayed appearance of atherosclerotic lesions in cerebral arteries.
D000818:Animals; D001011:Aorta / Q000187:drug effects*; D001161:Arteriosclerosis / Q000209:etiology; D002536:Cerebral Arteries / Q000187:drug effects*; D002791:Cholesterol, Dietary / Q000009:adverse effects; D003208:Concanavalin A / Q000494:pharmacology*; D003327:Coronary Disease / Q000209:etiology; D003331:Coronary Vessels / Q000187:drug effects*; D004727:Endothelium / Q000187:drug effects; D002537:Intracranial Arteriosclerosis / Q000209:etiology; D008252:Macaca fascicularis; D011817:Rabbits
D002791:Cholesterol, Dietary; D003208:Concanavalin A
Dati preliminari sulla diversa reazione endoteliale alla Con A, a differenti livelli dell'albero arterioso, nei conigli ed in scimie cynomolgus.