title: Changes in the neuronal activity of the ganglia of the myenteric plexus upon transmural electrical stimulation.
abstract: The neuronal activity of the myenteric plexus is recorded extracellularly in preparations isolated from cat duodenum, using tungsten microelectrodes with tip diameter 5-10 micrometers and resistance 0.5-2 mOhms. Transmural electrical stimulation after Burn and Rand (1960) with a pair of platinum electrodes is applied at a distance of 1 cm proximally from the place of recording. The responses of the single-spike neurones and of the erratic burst-type neurones to transmural electrical stimulation (series of impulses with frequency 1-20 Hz, duration of impulses 0.1-0.5 ms and suprathreshold current intensity) depend on the background neuronal activity. Thus, in the case of weak activity, stimulation with a frequency of 1-8 Hz results in activation of both types of neurones. A particularly high neuronal activity, stimulation with the same frequency results in inhibition. Transmural electrical stimulation does not change the character of the activity of steady burst-type neurones.
mesh_terms: D000200:Action Potentials; D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D005110:Extracellular Space / Q000502:physiology; D005725:Ganglia, Autonomic / Q000502:physiology*; D009197:Myenteric Plexus / Q000502:physiology*; D009474:Neurons / Q000145:classification / Q000502:physiology*; D013997:Time Factors