Cast vs extruded Biomer for biomedical applications.
The properties of solution grade and extrusion grade Biomer have been investigated and compared. In vivo blood compatibility studies using arteriovenous (AV) shunts of the cast and extruded materials show that extruded Biomer is more thromboresistant than solution cast Biomer. This has important implications for long-term implantation studies, since solution cast Biomer is used in artificial hearts. This study also indicates that extruded Biomer, dissolved in DMA and then solution cast, is more thromboresistant than cast solution grade Biomer. Surface studies using ESCA indicate a correlation between thromboresistance and surface soft segment concentration.
D000818:Animals; D001166:Arteriovenous Shunt, Surgical / Q000295:instrumentation*; D001672:Biocompatible Materials; D004285:Dogs; D005340:Fibrinogen / Q000032:analysis; D008855:Microscopy, Electron, Scanning; D010973:Platelet Adhesiveness; D011140:Polyurethanes; D013057:Spectrum Analysis
D001672:Biocompatible Materials; D011140:Polyurethanes; C031892:biomer; D005340:Fibrinogen