title: Studies on derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid. VI. Syntheses and properties of 2-N-aralkyl-alpha-sulphoderivatives of tert-amides of 2-amino-4-p-chlorophenylthiazole-5-acetic acid.
abstract: In the course of the studies on compounds with expected antiinflammatory and immunosuppressive activity several new tert-amides derivatives of 2-N-aralkylamino-alpha-sulpho-2-amino-4-p-chlorophenylthiazole-5-acetic acid were synthesized. Some of the previously described Schiff bases reacted with aqueous alcoholic solution of sodium bisulphite and as a result several (III-VIII) alpha-sulphoderivatives were obtained. The course of the reactions was studied and the structure of the new compounds was confirmed.
mesh_terms: D000577:Amides; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D007166:Immunosuppressive Agents / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis*
chemical_list: D000577:Amides; D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D013844:Thiazoles