title: Gastric inhibitory polypeptide release into the portal vein in response to intraduodenal glucose loads in anesthetized rats.
abstract: Gastric inhibitory polypeptide (GIP) release into the portal vein in response to duodenal instillation of glucose in doses of 0.695, 1.39, 2.78 and 5.56 mmol/kg body weight was studied in an acute condition in male Wistar rats. A rapid, dose-dependent, and significant rise in portal vein plasma GIP was found in response to increasing duodenal glucose loads, which could be described by Michaelis-Menten kinetics. It is suggested that the glucose-induced GIP release into the portal vein mainly is effected first after glucose has gained access inside the mucosal cells.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000378:metabolism; D005749:Gastric Inhibitory Polypeptide / Q000097:blood*; D005768:Gastrointestinal Hormones / Q000097:blood*; D005947:Glucose / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D011169:Portal Vein / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D005768:Gastrointestinal Hormones; D005749:Gastric Inhibitory Polypeptide; D005947:Glucose