The effects of single doses of alkali metal cations on deprivation-induced fluid consumption by rats.
The adult, male rat, trained to consume daily fluid intake in a deprivation-induced situation, was used to examine the effects of single doses of the monovalent alkali metal cations. Dosages of LiCl (0.25 - 5.0 mEq/kg, i.p.) showed a biphasic action with a threshold at 0.5 mEq/kg and a maximum dipsogenic action of 1 - mEq/kg. In contrast, single doses of NaCl (1.0 - 7.5 mEq/kg, i.p.) showed a continuing dipsogenic effect over the entire dose range. Single doses of KCl (0.25 - 5.0 mEq/kg, i.p.) or RbCl (0.5 - 5.0 mEq/kg, i.p.) had no effect on fluid consumption, while CsCl (0.5 - 2.1 mEq/kg, i.p.) caused decrements in fluid consumption with no clear dose-response relationship.
D000818:Animals; D002586:Cesium / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D008094:Lithium / Q000494:pharmacology; D008297:Male; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012413:Rubidium / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology; D014868:Water Deprivation
D002586:Cesium; D008094:Lithium; D012964:Sodium; D012413:Rubidium; D011188:Potassium