Trichinella spiralis in rats: in vivo effects of the bile and in vitro action of secretory IgA from bile.
The biliary secretion of rats is diverted from the choledoch duct to the bladder. These rats are resuscitated by sub-cutaneous injections of a salt solution and then infected with Trichinella spiralis larvae. It is shown that the number of adult worms is increased (+ 66%); as is the female larvae production (+ 51%); the females' length is also increased (+ 25%). 40 days after the infection the number of muscular larvae is considerably increased (+ 79%) in comparison with control rats. Secretory IgA (SIgA) from rats bile were tested in vitro on the female production of larvae. This larvae production was more inhibited (59%) by immune SIgA than by control SIgA (25%).
D000818:Animals; D001646:Bile / Q000276:immunology / Q000502:physiology*; D007070:Immunoglobulin A / Q000502:physiology*; D007071:Immunoglobulin A, Secretory / Q000502:physiology*; D009132:Muscles / Q000469:parasitology; D051381:Rats; D011919:Rats, Inbred Strains; D014234:Trichinella / Q000254:growth & development*; D014235:Trichinellosis / Q000469:parasitology*
D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory