Metabolic fate of n-methyl-N-dodecylnitrosamine in the rat, in relation to its carcinogenicity to the urinary bladder.
The metabolic fate of N-methyl-N-dodecylnitrosamine (MDN) was investigated in the rat, in order to elucidate a possible correlation between urinary metabolites and organotropic carcinogenicity to the urinary bladder of this N-nitrosamine. MDN was extensively metabolized in the rat, no unchanged MDN being found in the urine. The urinary metabolites identified were N-methyl-N-(3-carboxypropyl) nitrosamine (MCPN), N-methyl-N-(2-hydroxy-3-carboxy-propyl) nitrosamine, N-methyl-N-(carboxymethyl) nitrosamine, and N-methyl-N-(2-oxopropyl) nitrosamine. Thus the metabolic pattern of MDN was essentially similar to that of N-methyl-N-(4-hydroxybutyl) nitrosamine, a potent bladder carcinogen, in the rat. A possible important role of MCPN in the induction of bladder tumors by MDN is discussed.
D000818:Animals; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines / Q000378:metabolism*; D051381:Rats; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
D009602:Nitrosamines; C009914:N-nitrosomethyldodecylamine