title: Oxytetracycline hydrochloride in the horse: serum, synovial, peritoneal and urine concentrations after single dose intravenous administration.
abstract: Six adult mares were given a single intravenous injection of oxytetracycline HCl (50 mg/ml) at a dosage of 5 mg/kg. Serum, synovial fluid, peritoneal fluid, and urine oxytetracycline concentrations were measured serially over a 48-h period. The highest measured serum oxytetracycline concentration was 8.01 mcg/ml at 1/2 h. Oxytetracycline was detected in synovial fluid and peritoneal fluid, which obtained mean peak oxytetracycline concentrations of 4.43 mcg/ml and 4.20 mcg/ml, at 1/2 h and 1 h, respectively. These concentrations steadily declined in parallel with serum concentrations and were not measurable at 48 h. Urine oxytetracycline concentration was relatively high, with a peak concentration of 1565.2 mcg/ml at 1/2 h after drug administration.
mesh_terms: D000818:Animals; D001202:Ascitic Fluid / Q000378:metabolism; D006736:Horses / Q000378:metabolism*; D006801:Humans; D007275:Injections, Intravenous; D010118:Oxytetracycline / Q000097:blood / Q000378:metabolism* / Q000652:urine; D013582:Synovial Fluid / Q000378:metabolism
chemical_list: D010118:Oxytetracycline