title: Gentamicin therapy monitoring in seriously compromised patients.
abstract: Gentamicin therapy was monitored in 30 patients with severe infection and other concomitant disease states. The application of the nomogram of Hull and Sarubbi [6] produced good plasma levels and disappearance of the infective agent without evidence of drug toxicity in 70% of patients. The remaining 30% did not respond satisfactorily to the treatment and showed low drug serum concentrations; and them had heavy fluid losses; when we modified their treatment, outside of the nomogram guidelines, we observed a better response. Since gentamicin distributes essentially in extracellular water, subjects who have alterations of body fluids regulation should be carefully controlled.
mesh_terms: D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000188:drug therapy*; D005839:Gentamicins / Q000008:administration & dosage / Q000097:blood*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged
chemical_list: D005839:Gentamicins