title: Anticancer indole alkaloids of Rhazya stricta.
abstract: The leaves and roots of Rhazya stricta (Apocynaceae) yielded four indole alkaloids. Three of these isolated, vallesiachotamine (1), sewarine (3) and tetrahydrosecamine (4), displayed cytotoxic activity; polyneuridine (2) was not reported previously from this species. Tetrahydrosecaminediol (5), its acetate 6, and didemethoxycarbonyl-tetrahydrosecamine (7) were prepared from tetrahydrosecamine (4) by chemical reactions. The diol 5 was highly cytotoxic.
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007194:India; D007211:Indoles / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D010946:Plants, Medicinal / Q000032:analysis*
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D007211:Indoles