An extremely attenuated, live measles virus vaccine (CAM-EX). Persistence of low titer-antibody in institutionalized children with psychomotor retardation after vaccination.
Fifty children with psychomotor retardation, who had no detectable measles hemagglutination-inhibition (HI) antibody, were vaccinated with an extremely attenuated, live measles virus vaccine (CAM-EX). Only 10% of the children had fever after vaccination. No other symptoms were observed. Forty of 44 vaccinated children showed increase in HI antibody titers of 2(3) or more, with a geometric mean titer of 2(4.2). A five-year follow-up study revealed that the initially low-titer antibodies persisted well under conditions without a booster response due to natural measles.
D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008607:Intellectual Disability / Q000276:immunology*; D008297:Male; D008458:Measles Vaccine / Q000276:immunology*; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000276:immunology
D000914:Antibodies, Viral; D008458:Measles Vaccine; D014613:Vaccines, Attenuated