title: First detected eye-opening in albino vs. black coisogenic littermate mice.
abstract: Black and albino littermate mice of the same inbred strain were compared to see if precocious development of the visual system, as indicated by the first detected eye-opening within a litter, is due to alleles at the albino locus. In 32 litters of C57BL/6J-c2J mice the frequency of first detected eye-opening in albinos was not significant; there were no sex or maternal effects. In 16 litters of B10.D2/nSn-c4J mice the frequency of first detected eye-openings in male, but not female, blacks was significant; there were no maternal effects. The results surely do not rule out the possibility of abnormalities in the timing of the developmental sequence of the visual system in albinos; The entire sequence must be examined with appropriate genetic controls.
mesh_terms: D000417:Albinism / Q000235:genetics*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D005824:Genetics, Behavioral; D051379:Mice; D008810:Mice, Inbred C57BL / Q000502:physiology; D008817:Mice, Mutant Strains / Q000502:physiology; D013997:Time Factors; D014785:Vision, Ocular / Q000502:physiology*