N*-N*-S* tridentate ligand system as potential antitumor agents.
Compounds containing an N*-N*-S* tridentate ligand were synthesized and tested for antitumor activity against P-388 lymphocytic leukemia in mice. Of these, only 2,2'-bipyridyl-6-carbothioamide (1a) showed antitumor activity at relatively high dosage levels. Compound 1a was also evaluated against L-1210 and S180 cells in culture and found to have significant activity.
D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D007941:Leukemia P388 / Q000188:drug therapy; D008024:Ligands; D051379:Mice; D008815:Mice, Inbred Strains; D011725:Pyridines / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D008024:Ligands; D011725:Pyridines; D015082:2,2'-Dipyridyl; C033291:2,2'-bipyridyl-6-carbothioamide