Effect of indomethacin on local cerebral blood flow in awake, minimally restrained rats.
The effect of indomethacin (10 mg kg-1) on local CBF (1-CBF) was studied with autoradiographic techniques in awake, minimally restrained rats. When compared with uninjected awake control animals, those given indomethacin showed a reduction of 1-CBF by 25-45%. This reduction is somewhat less pronounced than that previously obtained in paralyzed animals maintained on 70% N2O (a reduction by 30-60%). An enhancement of the indomethacin response during nitrous oxide anesthesia was mainly observed in structures which show a maintained or increased CBF during anesthesia.
D000758:Anesthesia; D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D009609:Nitrous Oxide / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014851:Wakefulness
D009609:Nitrous Oxide; D007213:Indomethacin