Half-life of 13,14-dihydro-15-keto prostaglandin f2 alpha in peripheral plasma of the pig.
The metabolite of prostaglandin F2 alpha (PGF2 alpha ) namely 13,14-dihydro-15-keto-prostaglandin F2 alpha (PGFM), was administered as an intravenous bolus injection into five adult pigs. Concentrations of PGFM in blood collected periodically after injection indicated a biexponential decline suggesting a rapid distribution to the extracellular fluid and a slower elimination by metabolism. A mean half-life value of 14.97 +/- 1.33 (SD) minutes was calculated for the second component of the decline in PGFM concentration.
D000818:Animals; D015237:Dinoprost / Q000031:analogs & derivatives*; D005260:Female; D006207:Half-Life; D007774:Lactation; D010053:Ovary / Q000502:physiology; D011247:Pregnancy; D011460:Prostaglandins F / Q000097:blood*; D011863:Radioimmunoassay / Q000662:veterinary; D013552:Swine / Q000097:blood*
D011460:Prostaglandins F; C008228:15-keto-13,14-dihydroprostaglandin F2alpha; D015237:Dinoprost