Effects of vancomycin on renal function in rats.
To assess the effects of vancomycin on the kidney, we gave rats doses of 10, 50, 100, 200, and 400 mg/kg per day. Creatinine clearance and urine protein excretion did not differ significantly from the control values. Urine osmolality was unchanged. Mild histological changes occurred in rats given the highest dose. We conclude that although histopathological changes occurred at high doses, vancomycin does not alter renal function in rats.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003404:Creatinine / Q000652:urine; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009994:Osmolar Concentration; D011507:Proteinuria / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014640:Vancomycin / Q000494:pharmacology*
D014640:Vancomycin; D003404:Creatinine