title: Effects of treadmill running on oxidative capacity of regenerated skeletal muscle.
abstract: The purpose of the present study was to examine the effects of treadmill running on the oxidative capacity of regenerated rodent skeletal muscle. The soleus, plantaris, and gastrocnemius muscles were removed under general anesthesia from one hindlimb of young female rats (N = 15). The visible "white" portion of the latter muscle was minced into 1 mm3 fragments and autotransplanted leaving both the tibial and sural nerves intact. Six animals were treadmill run daily beginning 4 days post-surgery. Intensity and duration were progressively increased such that by day 45 the animals were running 1 h at 21.5 m . min-1 up a 15% grade, The regenerated muscle homogenates had a significantly lower capacity for maximal pyruvate + malate oxidation and smaller mass relative to the contralateral gastrocnemius. The exercise program significantly increased these parameters, tending to normalize the values. Some factor associated with exercise stimulated recovery from the muscular trauma.
mesh_terms: D000818:Animals; D004734:Energy Metabolism; D005260:Female; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008293:Malates / Q000378:metabolism; D009132:Muscles / Q000294:innervation* / Q000378:metabolism; D009416:Nerve Regeneration; D010807:Physical Endurance; D005082:Physical Exertion; D011773:Pyruvates / Q000378:metabolism; D051381:Rats; D012420:Running
chemical_list: D008293:Malates; D011773:Pyruvates; D007770:L-Lactate Dehydrogenase