Skin reactions to a urea-containing cream.
Patch tests with a cream (Calmuril) containing 10% urea were performed on 79 patients with eczematous skin disease; seven (9.9%) had positive tests. Patch tests with the ingredients of the cream were negative. It is suggested that the positive patch test reactions are toxic, due to hypertonicity and acidity of the cream.
D000293:Adolescent; D000328:Adult; D000368:Aged; D003877:Dermatitis, Contact / Q000209:etiology*; D003879:Dermatologic Agents / Q000009:adverse effects*; D004338:Drug Combinations / Q000009:adverse effects; D004342:Drug Hypersensitivity; D005260:Female; D006801:Humans; D007773:Lactates / Q000009:adverse effects*; D019344:Lactic Acid; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D014508:Urea / Q000009:adverse effects*
D003879:Dermatologic Agents; D004338:Drug Combinations; D007773:Lactates; C011698:lactic acid, urea drug combination; D019344:Lactic Acid; D014508:Urea