Pharmacokinetics of gentamicin in the juvenile dog.
The pharmacokinetics of gentamicin and/or creatinine clearances were investigated in eleven 5-month-old Beagles. A 2-compartment open model was used to describe the drug's disposition, as judged by error sums of squares and residual plot analyses. Half-life (elimination phase) was 60.9 +/- 7.8 minutes (mean +/- SD), the volume of distribution calculated from the area under the curve was 35.4 +/- 3.6 L/100 kg of body weight, and the clearance of the drug from the body was 4.08 +/- 0.62 ml/min/kg of body weight. The 24-hour creatinine renal clearance in these dogs was 3.82 +/- 0.92 ml/min/kg, consistent with gentamicin being eliminated mainly by glomerular filtration. Other pharmacokinetic values were also determined.
D000818:Animals; D003404:Creatinine / Q000652:urine; D004285:Dogs / Q000378:metabolism*; D005839:Gentamicins / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male
D005839:Gentamicins; D003404:Creatinine