Potential antitumor agents. XVII. physalin B and 25,26-epidihydrophysalin C from Witheringia coccoloboides.
An investigation of Witheringia coccoloboides (Dammer) A. T. Hunziker [Capsicum fuscoviolaceum (Cufodontis) Mort. And Standl.] roots has resulted in the isolation of two cytotoxic compounds: physalin B (1) and a novel physalin, which was characterized by spectral analysis as 25,26-epidihydrophysalin C (2). Both compounds have demonstrated cytotoxic activity in 9KB and 9PS tumor cells (in vitro). Physalin B (1) has demonstrated moderate activity against the 3PS mouse leukemia (in vivo).
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D066298:In Vitro Techniques; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010946:Plants, Medicinal / Q000032:analysis*; D012632:Secosteroids; D013256:Steroids
D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D012632:Secosteroids; D013256:Steroids; C033270:physalin B; C033271:25,26-epidihydrophysalin C