Phenylbutazone toxicosis in equidae: a biochemical and pathophysiological study.
Toxic effects of phenylbutazone (PBZ) in ponies and horses were studied, using a variety of biochemical, pathophysiologic, and pathologic methods. At dosage levels of 10 to 12 mg/kg of body weight/day for 8 to 10 days, ponies frequently developed clinical signs of toxicosis characterized by hypoproteinemia. Studies using 51CrCl3 demonstrated that PBZ caused a protein-losing gastroenteropathy. The plasma loss was usually associated with gastrointestinal ulceration, but sometimes occurred without obvious lesions in mildly affected animals. Similar studies (8.2 mg/kg/day for 13 days) in Thoroughbreds indicated that they were less susceptible to PBZ toxicity; however, a degree of hypoproteinemia occurred in 4 of 6 treated Thoroughbreds.
D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D001806:Blood Urea Nitrogen; D002432:Cecum / Q000473:pathology; D003106:Colon / Q000473:pathology; D005110:Extracellular Space; D005260:Female; D006734:Horse Diseases / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D006736:Horses; D008297:Male; D010653:Phenylbutazone / Q000097:blood / Q000506:poisoning*
D001798:Blood Proteins; D010653:Phenylbutazone