Morphology of early changes in liver carcinogenesis induced by methapyrilene.
Two weeks of treatment with the liver carcinogen methapyrilene induced a significant increase in mitochondria of periportal hepatocytes in F344 rats. Administration of [3H]-methapyrilene hydrochloride resulted in a pronounced concentration of bound radioactivity in the periportal hepatocytes, with mitochondria being the principal site of intracellular binding. The nuclei of the liver cells were unlabeled.
D000631:Aminopyridines; D000818:Animals; D005260:Female; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000139:chemically induced / Q000473:pathology*; D008701:Methapyrilene; D008854:Microscopy, Electron; D051381:Rats; D011916:Rats, Inbred F344; D013347:Subcellular Fractions / Q000473:pathology
D000631:Aminopyridines; D008701:Methapyrilene