A comparison between terminally radioiodinated hexadecenoic acid (125I-HA) and heptadecanoic acid (131I-H0A) in the dog heart.
The regional myocardial distribution of 125I-16-iodo-9-hexadecenoic acid (125I-HA) and 131I-17-iodo-heptadecanoic acid (131I-H0A) was determined in one normal dog and in five dogs within 5 min after coronary artery occlusion. The total myocardial uptake of 125I-H A was about 40% lower than that of 131I-H0A. The ratio 125I:131I in the normally perfused parts of the myocardium was 0.38-0.81, but the ischemic tissue showed a higher 125I:131I ratio (0.87-1.03), due to lower accumulation of 131I-H0A in ischemic myocardium. We conclude that both radioiodinated fatty acids are reliable indicators of myocardial perfusion and that iodo-heptadecanoic acid, when labeled with 123I, may be preferred to iodo-hexadecenoic acid as the labeled fatty acid for cardiac imaging agent in clinical practice.
D000818:Animals; D004285:Dogs; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D007457:Iodine Radioisotopes / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010169:Palmitic Acids / Q000378:metabolism; D011877:Radionuclide Imaging
D007457:Iodine Radioisotopes; D010169:Palmitic Acids