[Study of the catecholamines in the notochord of Anura Amphibia embryos. Its possible relationships with the adenyl-cyclase activity and the primordial germ cells migration (author's transl)].
Notochord from several Anura Amphibia embryos was investigated by cytochemical study. A green fluorescence was observed, indicating a catecholamine storage in the notochord, during a precise time of their development. A stimulation of the mesoblast area by catecholamine is suggested by the analogy between the catecholamine chordal distribution and the adenyl-cyclase activity of the chordo-mesoderm. This stimulation would be followed by a cAMP production directing the PGC migration. Treatment by L-dopa increases fluorescence in the notochord. Reserpine and alpha-methyl-paratyrosine decreases the notochord fluorescence, either by stocked catecholamine depletion in the case of reserpine, or by inhibition of their synthesis by alpha-methyl-para-tyrosine.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001001:Anura / Q000196:embryology*; D002395:Catecholamines / Q000032:analysis*; D002465:Cell Movement; D004625:Embryo, Nonmammalian / Q000032:analysis*; D005854:Germ Cells / Q000502:physiology*; D009672:Notochord / Q000032:analysis*; D011898:Ranidae / Q000196:embryology / Q000378:metabolism; D014982:Xenopus laevis / Q000196:embryology / Q000378:metabolism
D002395:Catecholamines; D000262:Adenylyl Cyclases
Mise en évidence de catécholamines dans la corde dorsale des embryons d'amphibiens anoures. relations possibles avec l'activité adénylate-cyclasique de cet organe et la migration des cellules germinales primordiales.