Alteration of a tumor cell distribution pattern by cytochalasin B.
Cytochalasin B pretreatment of tumor cells alters the distribution pattern of metastases after i.v. injection. We now have studied Cytochalasin B cell pretreatment affects the i.v. distribution and elimination of 125IUDR-labeled TA3-Ha tumor cells. We found no differences between control and CB-treated cells in their initial distribution. but 4-8 hours after the injection, in the redistribution phase, there were more CB cells than control cells extrapulmonally. Rather than a consequence of CB paralysis, we interpret the results in terms of altered surface properties of CB cells during their recovery.
D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D003571:Cytochalasin B / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D009362:Neoplasm Metastasis; D009366:Neoplasm Seeding; D009374:Neoplasms, Experimental / Q000473:pathology*; D013499:Surface Properties; D013997:Time Factors
D003571:Cytochalasin B