[Changes in plasma composition resulting in an increase in the osmotic pressure of venous blood during the cholinergic dilatation effect].
Stimulation of the sympathetic chain in the presence of alpha-receptor blocking agents caused cholinergic vasodilatation of the cat hind-limb vessels. The arterial-venous difference with respect to osmotic pressure (Posm), as well as to the content of K+, Na+, Ca2+, lactate, total protein, and inorganic phosphate was determined in blood samples collected during vasodilatation. Sympathetic stimulation in the presence of alpha-receptor-blocking agents agents increased the conductance of the hind-limb vessels and Posm of the venous blood (7.6 +/- 0.8 mOsm/l); both effects were abolished by atropine. During vasodilatation the content of K+, Na+ and lactate in venous blood plasma was increased, while that of total protein, inorganic phosphate and Ca2+ remained unchanged. The increase in Posm (73.7%) was found to be due to the rise in Na+. The data obtained suggest an increased intensity of metabolism in skeletal muscle during cholinergic vasodilatation.
D000818:Animals; D001790:Blood Physiological Phenomena; D001798:Blood Proteins / Q000032:analysis; D002118:Calcium / Q000097:blood; D002415:Cats; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D009132:Muscles / Q000098:blood supply*; D009997:Osmotic Pressure; D010710:Phosphates / Q000097:blood; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D013564:Sympathetic Nervous System / Q000502:physiology*; D014664:Vasodilation; D014680:Veins / Q000502:physiology
D001798:Blood Proteins; D007773:Lactates; D010710:Phosphates; D019344:Lactic Acid; D012964:Sodium; D011188:Potassium; D002118:Calcium
Izmeneniia sostava plazma, privodiashchie k uvelicheniiu osmoticheskogo davleniia venoznoĭ krovi pri kholinergicheskom rasshiritel'nom éffekte.