Pathogenesis and pathophysiology of ischemic heart disease.
Animal experiments illustrating the effects of coronary artery disease are described. These experiments show marked blunting of reactive hyperremia with 80% of narrowing, and markedly decreased resting blood flow with 90% narrowing of the coronary artery. With 60% stenosis, blunting of hyperemic response occurs with a 5 mm long stenosis and decreased resting blood flow with a 10 mm long stenosis. Further reduction of resting blood flow is demonstrated with serial narrowing. In 6 patients with variant angina, resting myocardial blood flow decreased during episodes of spontaneous angina. Similar results were found in 13 patients with variant angina after ergonovine administration.
D000818:Animals; D001011:Aorta / Q000503:physiopathology; D001783:Blood Flow Velocity; D003326:Coronary Circulation; D003327:Coronary Disease / Q000503:physiopathology*; D004195:Disease Models, Animal; D004562:Electrocardiography; D006439:Hemodynamics; D006801:Humans; D008297:Male