Heterotopic induction of osteogenesis in mice lethally irradiated and repopulated with syngeneic bone marrow cells.
Decalcified rat bone matrix or sequentially treated rat bone gelatin, as well as dog transitional epithelium when implanted intramuscularly in mice induce cartilage, bone and bone marrow formation. Heterotopic bone induction is markedly reduced or abolished when animals are irradiated prior to implantation of decalcified bone matrix or transitional epithelium. Repopulation of lethally irradiated mice with syngeneic bone marrow cells restores the osteoinductive competence, suggesting that responding cells in bone induction system are derived, or connected with, bone marrow cells.
D000818:Animals; D001854:Bone Marrow Cells; D001857:Bone Matrix / Q000637:transplantation; D004848:Epithelium / Q000637:transplantation; D005260:Female; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D010012:Osteogenesis; D014183:Transplantation, Heterologous; D014185:Transplantation, Isogeneic