title: Preanaesthetic medication with rectal diazepam in children.
abstract: With the purpose of avoiding injections to children, the quality of rectal premedication with a solution of diazepam (Apozepam) was investigated in a double-blind study. Compared with a lytic cocktail (containing pethidine, promethazine and chlorpromazine), adequate preanaesthetic sedation was obtained with rectally administered diazepam in a dose of 0.75 mg kg-1. However, following rectal diazepam, the majority of the children were very restless during recovery, but the combination of diazepam premedications and a small dose of lytic cocktail given i.m. during anaesthesia secured a smooth recovery in practically all children. The proportion of cases classified as "unsatisfactory' was higher in children below the age of 5 years than in the older children.
mesh_terms: D002648:Child; D002675:Child, Preschool; D002746:Chlorpromazine; D003975:Diazepam / Q000008:administration & dosage*; D004311:Double-Blind Method; D004338:Drug Combinations; D006801:Humans; D007036:Hypothermia, Induced; D007223:Infant; D007273:Injections, Intramuscular; D008614:Meperidine; D011229:Preanesthetic Medication; D011398:Promethazine; D012007:Rectum
chemical_list: D004338:Drug Combinations; D008614:Meperidine; D011398:Promethazine; D003975:Diazepam; D002746:Chlorpromazine