The effect of experimentally induced intestinal perforation at an early developmental stage.
In chick embryos we studied the effect on intestinal development of an experimentally induced perforation and a vascular lesion performed at an early developmental stage. The results show that an intestinal perforation will heal, but may lead to intestinal atresia with microscopic signs of meconium peritonitis. Conversely, a vascular lesion induced at an early stage of development does not lead to intestinal atresia, while a vascular lesion performed at a late stage of development does result in intestinal atresia, but without any signs of meconium peritonitis.
D000818:Animals; D002642:Chick Embryo; D007409:Intestinal Atresia / Q000209:etiology*; D007416:Intestinal Perforation / Q000209:etiology / Q000503:physiopathology*; D007422:Intestines / Q000196:embryology; D008470:Meconium / Q000378:metabolism; D010538:Peritonitis / Q000209:etiology / Q000473:pathology; D013152:Splanchnic Circulation; D014945:Wound Healing