The effect of indapamide on muscle blood flow in hypertensive patients.
The effect of indapamide on the peripheral circulation was investigated in hypertensive patients using a xenon washout technique. Resting muscle blood flow increased by 38% after 1 week's treatment in 5 patients and by 52.6% after 6 weeks treatment in 4 patients. Exercise muscle blood flow increased by 18% in 4 patients after 6 weeks' treatment. Resting supine and standing blood pressure was decreased by indapamide after 2, 4 and 6 weeks of treatment. Exercise systolic blood pressure was not changed by indapamide. The results in this pilot study suggest that peripheral resistance is reduced by a direct action on the vessel wall.
D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007190:Indapamide / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000098:blood supply* / Q000187:drug effects; D005082:Physical Exertion; D010865:Pilot Projects; D012039:Regional Blood Flow / Q000187:drug effects
D000959:Antihypertensive Agents; D004232:Diuretics; D007190:Indapamide