A specific type of dislipidaemia-a complex between monotypic immunoglobulins and lipids.
Some bibliographic data suggest that serum lipids bound to monotypic immunoglobulins (Ig-s)could represent one specific type of dislipidaemia in man. In this paper 5 cases confirming such a suggestion are described. After agarose gel electrophoresis lipids bound to monotypic Ig-s moved as one separate lipoprotein category clearly different from alpha and beta lipoproteins. The electrophoretic mobility of Ig-s binding lipids was not always the same and depended on the immunochemical isotype of Ig (fig. 2). The lipid concentration in the sera, containing lipid bound Ig-s was found to be very low (table 1). Both neutral lipids and phospholipids were extracted from the isolated monotypic Ig-s (figs 4 and 5, table 2).
D002784:Cholesterol / Q000097:blood; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism*; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D009101:Multiple Myeloma / Q000097:blood / Q000276:immunology; D010743:Phospholipids / Q000097:blood
D007136:Immunoglobulins; D008055:Lipids; D008074:Lipoproteins; D010743:Phospholipids; D002784:Cholesterol