The effect of a virtually cholesterol-free, high-linoleic-acid vegetarian diet on serum lipoproteins of children with familial hypercholesterolemia (type II-A).
The effect of a virtually cholesterol-free, high-linoleic-acid vegetarian diet and a high-linoleic-acid "normal" diet with a moderate cholesterol content was tested in 39 children heterozygote for hypercholesterolemia type II-A. The diets were administered in an outpatient cross-over design of two periods of 10 weeks each and the serum lipoproteins were analyzed at the end of the two 10-week periods. The vegetarian diet induced a decrease in serum concentrations of LDL-II total and free cholesterol and of apo-B, by an average of 10%, whereas HDL cholesterol and apo-A-I decreased by 4%. The disproportionately large change in LDL compared to the small change in HDL was interpreted as an antiatherogenic effect of the vegetarian diet.
D000293:Adolescent; D001053:Apolipoproteins / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D014676:Diet, Vegetarian; D004041:Dietary Fats / Q000008:administration & dosage; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood* / Q000178:diet therapy; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage; D008074:Lipoproteins / Q000097:blood*
D001053:Apolipoproteins; D002791:Cholesterol, Dietary; D004041:Dietary Fats; D008041:Linoleic Acids; D008074:Lipoproteins; D002784:Cholesterol; D019787:Linoleic Acid