Progestins during pregnancy and hypospadias.
In a sample of 3,602 male newborns we found 33 patients with hypospadias; eight of them were exposed to progestins during early pregnancy. The relative risk for hypospadias after exposure was 1.75 (confidence intervals 0.5 - 4.4). Progestin intake during early pregnancy does not measurably contribute to the incidence of hypospadias in the population studied.
D005260:Female; D006801:Humans; D007021:Hypospadias / Q000139:chemically induced*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011297:Prenatal Exposure Delayed Effects; D011372:Progestins / Q000009:adverse effects*; D012306:Risk
D011372:Progestins