[Leucocyte chemotaxis in patients treated with chronic haemodialysis (author's transl)].
Granulocytic and monocytic chemotaxis are studied by means of Boyden's modified method using as chemotactic agent human serum complement activated by Zymosan. The study has been made on healthy controls and a group of patients suffering from chronic renal failure treated with periodic haemodialysis. Observations were made before and after the dialysis session. In the patients with chronic renal failure is observed a decrease in leucocytic mobility of granulocytes and monocytes which give chemotactic granulocytic and monocytic indexes of 32.1 +/- 3.1 and 32.3 +/- 3.5 with relation to healthy controls with indexes of 46.7 +/- 8.4 and 37.0 +/- 4.3 and with significative differences between the measurements of p less than 0.001 and p less than 0.005 respectively. The parametres of polymorphonuclear and monocytic kinetics did not improve after the haemodialysis session. The possible mechanisms which produce such chemotactic leucocytic deficit in uraemics and the non-positive influence of the dialysis session on such deficit are hereby discussed.
D000328:Adult; D002634:Chemotaxis, Leukocyte; D006098:Granulocytes / Q000502:physiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008875:Middle Aged; D009000:Monocytes / Q000502:physiology; D006435:Renal Dialysis
Quimiotaxis leucocitaria en enfermos tratados con hemodiálisis crónica.