title: Immediate and delayed onset "skip area" dermatitis presumed secondary to topical phenol exposure.
abstract: A 21-year-old man was in brief accidental skin contact with epoxy resin stripper containing 10% phenol. He developed a painful, superficial necrotic eruption which slowly extended proximally without any further contact with the chemical, leaving skip areas of normal skin. About 3 and 7 months later he reported spontaneous flares within the area of original contact. Gradual release from an initially formed phenol-protein complex is thought to be responsible for the progression beyond the contact area and the delayed reaction.
mesh_terms: D000287:Administration, Topical; D000328:Adult; D003877:Dermatitis, Contact / Q000209:etiology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced; D006969:Hypersensitivity, Immediate / Q000139:chemically induced; D008297:Male; D010636:Phenols / Q000009:adverse effects*; D012867:Skin / Q000473:pathology
chemical_list: D010636:Phenols