[Effect of busulfan on the germ cell line of the quail embryo (author's transl)].
Busulfan was injected into the albumen of the quail egg on the 56th hour of incubation. The subjects injected with a high dose (9.6 mg/kg) showed at 15 days of incubation (and 2 days after hatching in the females) a clear cut sexual differentiation of their gonads. The germ cells were degenerating and the ovaries became sterile. 3 out of 4 testes wee sterile. However, the gonads were generally smaller than the normal ones through the flattening of the ovarian cortex or the reduction of the number and size of the testicular cords.
D000818:Animals; D002066:Busulfan / Q000494:pharmacology*; D005260:Female; D006066:Gonads / Q000187:drug effects* / Q000196:embryology; D008297:Male; D011784:Quail / Q000196:embryology*
D002066:Busulfan
Action du busulfan sur la lignée germinale de l'embryon de caille.