title: A note on drug trials in schistosomiasis.
abstract: In schistosomiasis, if the subjects of drug trials are in contact with potentially contaminated water, then differences in the chemotherapeutic response to the same dose of a drug given in the same endemic area in different seasons, may be related to different levels of transmission. Because a reduction in egg excretion may occur from causes other than chemotherapy, moderate antischistosomal activity of a drug cannot be concluded in the absence of a control group.
mesh_terms: D004341:Drug Evaluation / Q000379:methods*; D006801:Humans; D006826:Hycanthone / Q000627:therapeutic use; D007546:Isoquinolines / Q000627:therapeutic use*; D011223:Praziquantel / Q000627:therapeutic use*; D012548:Schistosoma haematobium; D012552:Schistosomiasis / Q000188:drug therapy* / Q000635:transmission; D012621:Seasons; D013636:Tanzania
chemical_list: D007546:Isoquinolines; D006826:Hycanthone; D011223:Praziquantel