Relationship between fibrin clot retraction and tumorigenesis in C3H/10T1/2 cells.
Fibrin clot retraction (FCR) was studied in C3H/10T1/2 murine fibroblasts. These cells were able to induce FCR with high efficiency during resting phase as well as during active growth. C3H/10/T1/2 cells which became tumorigenic after X-irradiation lacked FCR activity. Non-tumorigenic revertant clones regained the capacity to induce FCR, while revertants which progressively back-reverted to the neoplastic state showed intermediate FCR activity. These unstable revertants, when again fully tumorigenic, completely lost FCR activity.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D003018:Clot Retraction; D004247:DNA / Q000096:biosynthesis; D005337:Fibrin / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism*; D051379:Mice; D008809:Mice, Inbred C3H; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000097:blood*
D005337:Fibrin; D004247:DNA