title: Disproportional loss of membrane constituents in the course of erythrocyte aging.
abstract: Acetylcholine esterase activity and sialic acid content were estimated in human erythrocytes separated according to their densities and after fragmentation in vitro by heating or a combined hyperosmolaric-mechanical stress. In vivo aged cells showed a disproportional loss of both membrane constituents. Fragmentation of erythrocytes in vitro resulted in a proportional loss of acetylcholine esterase activity and sialic acid. Young cells are more prone to fragmentation by heat than older ones.
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood; D002499:Centrifugation, Density Gradient; D004905:Erythrocyte Aging; D004910:Erythrocyte Membrane / Q000502:physiology*; D004912:Erythrocytes / Q000502:physiology*; D006801:Humans; D012794:Sialic Acids / Q000097:blood
chemical_list: D012794:Sialic Acids; D000110:Acetylcholinesterase