Malignant hyperthermia-triggering liability of selected inhalant anesthetics in swine.
Twenty pigs, known to be malignant hyperthermia (MH)-susceptible by previous MH-positive [MH(+)] reactions to halothane testing, were given 5 inhalant anesthetics. The number of MH(+) responses evoked by the different anesthetics varied. In response to halothane, isoflurane, and enflurane, MH(+) reactions were exhibited by 12, 11, and 7 pigs, respectively. The number of MH(+) reactions to nitrous oxide (0) and methoxyflurane (1) was significantly (P = 0.02) less. In the present study, all 4 halogenated-hydrocarbon volatile liquid inhalant anesthetics were capable of evoking a MH(+) reaction in susceptible pigs.
D000769:Anesthesia, Inhalation / Q000662:veterinary; D000777:Anesthetics; D000818:Animals; D004341:Drug Evaluation / Q000662:veterinary; D005260:Female; D008305:Malignant Hyperthermia / Q000209:etiology / Q000662:veterinary*; D009609:Nitrous Oxide; D013552:Swine; D013553:Swine Diseases / Q000209:etiology*
D000777:Anesthetics; D009609:Nitrous Oxide