[Effect of DL-allyglycine on amygdala kindling in the rat (author's transl)].
The effect of decreased cerebral GABA levels on the development of amygdaloid kindling in rats was investigated. DL-Allylglycine, an inhibitor of glutamic acid decarboxylase (GAD), administered for 2 or 9 days (100 mg/kg and 50 mg/kg respectively) was found to accelerate the kindling process. The results are discussed according to a possible role of GABA mechanisms in the kindling phenomenon.
D000501:Allylglycine / Q000494:pharmacology*; D000679:Amygdala / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D005625:Frontal Lobe / Q000187:drug effects / Q000502:physiology; D005998:Glycine / Q000031:analogs & derivatives*; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D009778:Occipital Lobe / Q000187:drug effects / Q000502:physiology; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000501:Allylglycine; D005680:gamma-Aminobutyric Acid; D005998:Glycine
Effet de la DL-allylglycine sur l'embrasement amygdalien chez le rat.