The effect of N-(3, 5, 5-trimethyl-2-pyrazolino-1-carbonimidoyl)-guanidine hydrochloride (BPC-151) on lipid metabolism of rats and pigs.
The effect of BPC-151 on the lipid level in the rat and pig blood serum and on the lipid content in the homogenate of rat liver, on pyruvate and lactate in the blood serum of pigs, and on aggregation of blood platelets in pigs was investigated. Hyperlipidemia was induced by administration for 6 months a high lipid diet containing coconut oil, cholesterol and cholic acid. The hypolipemic action of BPC-151, particularly against the increase in free fatty acids, was demonstrated. The investigated compound did not affect the level of lactate in the pig blood serum but depressed the aggregation of blood platelets.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002784:Cholesterol / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D050356:Lipid Metabolism; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013552:Swine; D014280:Triglycerides / Q000378:metabolism
D001786:Blood Glucose; D000960:Hypolipidemic Agents; D011720:Pyrazoles; D014280:Triglycerides; C033199:BPC 151; D002784:Cholesterol