title: Opiates inhibit the dopaminergic enhancement of the renal response to aldosterone in the rat.
abstract: 1. Both naloxone, an opiate antagonist, and levorphanol, an opiate agonist, inhibit the enhanced renal response to aldosterone produced by both l-dopa pretreatment and a high K+ diet. 2. This supports the evidence for a common mechanism of action for the enhancement of the renal response to aldosterone produced by l-dopa and a high K+ diet. Whether this mechanism is dopaminergic or opiate is uncertain. 3. The inhibition of the enhanced response, produced by l-dopa, by opiates is consistent with previous findings of displacement of 3H-dopamine from renal homogenates by opiates and supports the hypothesis that the binding sites relate to the renal response to aldosterone.
mesh_terms: D000450:Aldosterone / Q000494:pharmacology*; D000818:Animals; D004298:Dopamine / Q000502:physiology*; D005260:Female; D007668:Kidney / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology; D009294:Narcotics / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009294:Narcotics; D009270:Naloxone; D000450:Aldosterone; D004298:Dopamine