title: [Reflux disease and sphincter pressure].
abstract: Between patients with reflux oesophagitis (n = 8), patients with symptoms of reflux without oesophagitis (n = 27) and controls (n = 17) recordings of lower oesophageal sphincter pressure have shown no significant differences of mean sphincter pressure but a significantly lower increase of mean sphincter pressure in patients with oesophagitis and/or symptoms of reflux after pentagastrin (6 microgram/Kg b.w., s.c.) by means of pull-through perfusionsmanometry. Nearly in half of the patients with oesophagitis and symptoms of reflux basal sphincter pressure and sphincter reaction on pentagastrin were found in a normal range. Disturbances of basal sphincter pressure and its reaction on pentagastrin have shown a dependence on the anamnesis duration.
mesh_terms: D004942:Esophagitis, Peptic / Q000503:physiopathology*; D004943:Esophagogastric Junction / Q000503:physiopathology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000503:physiopathology*; D006801:Humans; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D011312:Pressure
chemical_list: D010418:Pentagastrin
vernacular_title: Refluxkrankheit und Sphinkterdruck.