title: Spontaneous and busulphan-induced sister-chromatid exchange (SCE) frequencies in haematologically normal human bone marrow and lymphocytes.
abstract: In a study of 14 patients who were not treated with either chemotherapy or irradiation, 13 patients had lower sister-chromatid exchange (SCE) frequencies in their bone-marrow cells than in their lymphocytes. For both bone marrow and lymphocytes, there was significant inter-patient variability in SCE frequencies, but there was no correlation between the bone-marrow and lymphocyte values. The effect of exposing bone-marrow cells to busulphan (BUS) in vitro was investigated using doses up to 5.0 microgram/ml. The dose-response relationships between BUS and SCEs in vitro were found to be similar for bone marrow and lymphocytes.
mesh_terms: D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000648:ultrastructure*; D001943:Breast Neoplasms / Q000235:genetics; D002066:Busulfan / Q000494:pharmacology*; D002277:Carcinoma / Q000235:genetics; D002478:Cells, Cultured; D002875:Chromosomes / Q000187:drug effects; D003434:Crossing Over, Genetic; D004305:Dose-Response Relationship, Drug; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure*; D008297:Male; D008545:Melanoma / Q000235:genetics; D008875:Middle Aged; D012854:Sister Chromatid Exchange; D012878:Skin Neoplasms / Q000235:genetics
chemical_list: D002066:Busulfan