Mutagenicity and alpha-hydroxylation of N-nitrosopyrrolidine and N-nitrosopiperidine: a possible correlation.
N-Nitrosopyrrolidine (NPyrr) and N-nitrosopiperidine (NPip) are carcinogenic and mutagenic cyclic nitrosamines. Their biotransformation by rat liver post-mitochondrial fraction into 1,4-butanediol and 1,5-pentanediol, respectively, is evaluated by determining these ultimate metabolites with a sensitive and suitable method. Their mutagenic activity towards the Salmonella typhimurium strain TA 1530 was simultaneously observed. A relationship exists between their metabolism and their mutagenicity. alpha-Hydroxylation is probably the critical metabolic metabolism of cyclic nitrosamines.
D000818:Animals; D001711:Biotransformation; D002072:Butylene Glycols / Q000378:metabolism; D006900:Hydroxylation; D008297:Male; D009153:Mutagens / Q000378:metabolism* / Q000633:toxicity; D009242:N-Nitrosopyrrolidine / Q000378:metabolism* / Q000633:toxicity; D009602:Nitrosamines / Q000378:metabolism* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D002072:Butylene Glycols; D009153:Mutagens; D009602:Nitrosamines; C002743:N-nitrosopiperidine; D009242:N-Nitrosopyrrolidine