It is possible to stimulate intestinal calcium absorption during experimental chronic renal failure.
To explore the assumption on the functional inadequacy of renal alternative vitamin D synthesis during chronic renal failure, 50 subtotally-nephrectomized rats were treated with dihydrotachysterol, androgens, estrogens or androgens + estrogens. Fractional duodenal calcium absorption and calcium-binding protein content of intestinal mucosa were determined. Fractional duodenal calcium absorption was significantly decreased in uremic rats (6.61 +/- 1.64%). Dihydrotachysterol or androgen + estrogen administration lead to 3-fold increase in fractional duodenal calcium absorption, accompanied by the enhancement in calcium-binding protein content of mucosal layer. It is concluded that it is possible to stimulate intestinal calcium absorption during experimental chronic renal failure, probably via the rehabilitation of 1,25(OH)2D2 production.
D000728:Androgens / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000032:analysis / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000032:analysis / Q000378:metabolism; D004097:Dihydrotachysterol / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000032:analysis / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000728:Androgens; D002135:Calcium-Binding Proteins; D004967:Estrogens; D004097:Dihydrotachysterol; D002118:Calcium