Derivatives of n-aryl-N-amino piperazines as potential cardiovascular agents.
24 new substituted piperazino guanidines and 34 substituted benzylideno- or benzylamino-4-phenyl piperazines were synthesized and evaluated for their cardiovascular activity. Several compounds of the above two series exhibited vasopressor or vasodepressor activity without modifying the carotid occlusion (CO) and noradrenaline (NA) induced pressor responses.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002317:Cardiovascular Agents / Q000138:chemical synthesis*; D004285:Dogs; D005260:Female; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology
D002317:Cardiovascular Agents; D010879:Piperazines; D009638:Norepinephrine