Abnormal cardiovascular and electrocardiographic profiles and cardiac glycogen content in rabbits injected with scorpion venom.
Cardiovascular and ECG abnormalities were studied following injection of venom of Buthus tamulus, a common scorpion found in South India. Venom was administered in doses of 2 and 4 mg/kg body weight. Subsequent estimation of glycogen content of different chambers of the heart, showed a significant reduction in tissue glycogen levels in both atria and ventricles in animals treated with a venom dose of 2 mg/kg. However, a significant reduction occurred only in atria with a higher venom dose of 4 mg/kg.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D006003:Glycogen / Q000032:analysis*; D006321:Heart / Q000187:drug effects*; D009206:Myocardium / Q000032:analysis*; D011817:Rabbits; D012604:Scorpion Venoms / Q000008:administration & dosage / Q000494:pharmacology*
D012604:Scorpion Venoms; D006003:Glycogen