title: [Epidemiology of hypothyroidism due to congenital malformation of the gland: athyreosis or ectopic thyroid (author's transl)].
abstract: The neonatal characteristics of 322 cases of hypothyroidism due to congenital malformation of the gland --athyreosis or ectopic thyroid--were compared with a national sample of births (N = 11,373), and a sample of births in public hospitals in Paris (N = 12, 895), in order to see if genetic factors were involved in the etiology of the disease. The hypothesis of multifactorial inheritance has been especially studied. Factors which appeared compatible with a multifactorial etiology were: marked excess of females (74%); higher frequency of twins (3.4%), of maternal familial thyropathy (9.2% among the mothers), of familial cases of thyroid malformations (11 cases); higher frequency of associated malformations of multifactorial origin (5.4%). But this type of malformation was not more frequent among siblings and relatives of the studied cases; it is thus not possible to accept the hypothesis of multifactorial inheritance without reservation.
mesh_terms: D000328:Adult; D003409:Congenital Hypothyroidism; D005260:Female; D005602:France; D006801:Humans; D007037:Hypothyroidism / Q000453:epidemiology / Q000235:genetics; D007231:Infant, Newborn; D008297:Male; D013961:Thyroid Gland / Q000002:abnormalities*
vernacular_title: Epidémiologie des hypothyoïdies congénitales malformatives.