Composite randomization designs for clinical trials.
This paper proposes a new design for the augmentation of a randomized clinical trial through the participation of private physicians who do not randomize individual patients. Each private physician is randomly assigned a study treatment which he or she uses consistently for all eligible patients. A statistically rigorous method of analysis is described, the efficiency of this design is evaluated, and its limitations discussed.
D002986:Clinical Trials as Topic / Q000379:methods*; D006801:Humans; D010819:Physician's Role; D011336:Probability; D011897:Random Allocation; D012380:Role