title: [Effect of amitrol on Claviceps fusiformis, strain SD 58].
abstract: The influence of amitrole (3-amino-1,2,4-triazole) on growth, alkaloid formation and on some aromatic as well as ergoline pathway specific enzymes were studied in Claviceps strain, SD 58. In a phosphate-rich medium the addition of amitrole can partially reverse the alkaloid-depressing effect of phosphate. Using a typical fermentation medium amitrole reduces the activities of ergoline specific enzymes but increases drastically tryptophan synthase activity and to a lesser extent transaminase of aromatic amino acids.
mesh_terms: D019883:Alkyl and Aryl Transferases; D000619:Aminohydrolases / Q000378:metabolism; D000640:Amitrole / Q000494:pharmacology*; D002967:Claviceps / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development*; D014166:Transferases / Q000378:metabolism; D014230:Triazoles / Q000494:pharmacology*; D014367:Tryptophan Synthase / Q000378:metabolism
chemical_list: D014230:Triazoles; D014166:Transferases; D019883:Alkyl and Aryl Transferases; C032409:tryptophan dimethylallyltransferase; C032757:chanoclavin-I-cyclase; D000619:Aminohydrolases; D014367:Tryptophan Synthase; D000640:Amitrole
vernacular_title: Einfluss von Amitrol auf Claviceps fusiformis, Stamm SD 58.