In vivo effect of levamisole on responses of blood lymphocytes to mitogens in calf.
In vivo administration of levamisole in calf enhances the capacities of peripheral blood lymphocytes to undergo blastic transformation in response to both phytohemagglutinin and concanavalin A. This effect is dose-dependent and persists at least five days. These results confirm that levamisole is efficient not only in immunodepressed but also in normal individual, and suggest that target cells susceptible to levamisole are different at systemic and local level.
D000818:Animals; D002417:Cattle / Q000276:immunology*; D003208:Concanavalin A / Q000494:pharmacology*; D007978:Levamisole / Q000008:administration & dosage / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000276:immunology; D010835:Phytohemagglutinins / Q000494:pharmacology*
D010835:Phytohemagglutinins; D003208:Concanavalin A; D007978:Levamisole