Shuttle behavior in rats after lesion of hippocampal pyramidal cells with kainic acid.
Rats with bilateral lesions of hippocampal pyramidal cells in the subfield CA 3 with intracerebroventricular kainic acid (0.1 microgram/2 microliter) made more shuttle responses to a buzzer in Pavlovian paradigm, classical conditioning and two-way active avoidance but did not differ remarkably in pseudoconditioning and avoidance conditioning without stimulus pairing, than sham-operated and intact control rats. Animals with unilateral lesion in the CA 3 hippocampal subfield showed no differences in these shuttle situations. The results suggest that CA 3 hippocampal pyramidal cells are of particular importance to the establishment of the stimulus-stimulus relations in the brain.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000033:anatomy & histology; D003214:Conditioning, Classical / Q000187:drug effects; D006624:Hippocampus / Q000502:physiology*; D007276:Injections, Intraventricular; D007608:Kainic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects*; D008297:Male; D011712:Pyramidal Tracts / Q000502:physiology*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011759:Pyrrolidines; D007608:Kainic Acid