An autosomal gene assignment in a marsupial: the gene for LDH-A is on chromosome 5 of the red kangaroo, Macropus rufus.
A number of somatic cell hybrids between red kangaroo (Macropus rufus) and mouse cells, which lose marsupial chromosomes, were found to express the kangaroo form of LDH-A. Concordance between the expression of marsupial LDH-A and the presence of chromosome 5 in the hybrid cells and selected subclones enabled the gene for LDH-A to be assigned to this chromosome. This is the first autosomal gene assignment in a marsupial and should prove important for chromosome mapping in the red kangaroo and in many other species of marsupials.
D000818:Animals; D002874:Chromosome Mapping; D002999:Clone Cells / Q000648:ultrastructure; D005796:Genes; D006822:Hybrid Cells / Q000648:ultrastructure; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000235:genetics*; D007614:Macropodidae / Q000235:genetics*; D008394:Marsupialia / Q000235:genetics*; D051379:Mice
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase