title: The effects of sex hormones, prolactin, and chorionic gonadotropin on pineal electrical activity in guinea pigs.
abstract: Microelectrophoretic application of sex hormones onto pineal cells in guinea pigs has shown different responses in pregnant females as compared to males. In pregnant females estrone caused excitation in 74% of the cells tested, while progesterone and testosterone, prolactin, and HCG were inhibitory in a majority of the cells tested, while progesterone and testosterone, prolactin, and HCG were inhibitory in a majority of the cells. In contrast, in males estrone caused excitation of only 19% but inhibition of 37%. A smaller percentage of cells was inhibited by progesterone, while the predominant response to testosterone was excitation. These results suggest that the pineal gland may be under a feedback control.
mesh_terms: D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D004970:Estrone / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D010870:Pineal Gland / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D011374:Progesterone / Q000494:pharmacology*; D011388:Prolactin / Q000494:pharmacology*; D012737:Sex Factors; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D006063:Chorionic Gonadotropin; D004970:Estrone; D013739:Testosterone; D011374:Progesterone; D011388:Prolactin