The effect of oxandrolone on low and high density lipoprotein profiles in retired breeder rats.
The retired breeder rat, an animal known to undergo premature aging and to develop hypercholesterolemia, was studied to determine the effect of oxandrolone, a synthetic hypolipidemic steroid, on serum lipoprotein subfractions. The methods utilized for this study included density ultracentrifugation, electron microscopic lipoprotein particle sizing, and disc gel electrophoresis. The data confirmed the cholesterol-lowering ability of oxandrolone and demonstrated that its effect on total serum cholesterol was limited to the low and high density lipoprotein subclasses. The drug-treated group had 50% less LDL cholesterol and 25% less HDL cholesterol. Though there was an absolute decrease in total serum cholesterol in both these fractions, there was a re-distribution of cholesterol, such that post-treatment LDL carried less cholesterol and HDL more cholesterol on a percentage basis than found in pre-treatment values. In the light of current concepts of atherogenicity these alterations are of interest and potentially of considerable value.
D000375:Aging; D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004591:Electrophoresis, Polyacrylamide Gel; D006937:Hypercholesterolemia / Q000188:drug therapy; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D010074:Oxandrolone / Q000494:pharmacology* / Q000627:therapeutic use; D010316:Particle Size; D051381:Rats
D000924:Anticholesteremic Agents; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D010074:Oxandrolone