title: Drug-polymer combinations. Part 1: The preparation of sustained release drugs by combination with ion exchanging resins.
abstract: The preparation of procainamide and propranolol resinates is described. By in vivo experiments with propranolol resinate as model substance the release rate as a function of crosslinking degree and particle size is studied. An in vitro test is carried out to compare the performance as prolonged release preparation of a resinate, e.g. procainamide resinate, with the action of the pure drug and of a Durette formulation.
mesh_terms: D003692:Delayed-Action Preparations; D007475:Ion Exchange Resins; D007700:Kinetics; D011342:Procainamide / Q000008:administration & dosage; D011433:Propranolol / Q000008:administration & dosage
chemical_list: D003692:Delayed-Action Preparations; D007475:Ion Exchange Resins; D011433:Propranolol; D011342:Procainamide