Cerebrospinal fluid antibiotic levels during treatment of shunt infections.
Twenty patients with documented cerebrospinal fluid shunt infections were treated with daily intraventricular injections of methicillin, cephalothin, or gentamicin without removal of the shunt or external ventricular drainage. Periodic determinations of intraventricular antibiotic concentration revealed significant levels in relation to the established minimum inhibitory concentration in all cases.
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000134:cerebrospinal fluid*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000209:etiology; D002512:Cephalothin / Q000008:administration & dosage / Q000134:cerebrospinal fluid; D002557:Cerebrospinal Fluid Shunts / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005839:Gentamicins / Q000008:administration & dosage / Q000134:cerebrospinal fluid; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007276:Injections, Intraventricular; D008712:Methicillin / Q000008:administration & dosage / Q000134:cerebrospinal fluid
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D008712:Methicillin; D002512:Cephalothin