title: Diabetes mellitus in the chimpanzee (Pan troglodytes).
abstract: Glucose intolerance was found in four adult chimpanzees. The response of glucose, insulin, C-peptide, and glucagon to intravenous glucose and tolbutamide stimulations revealed impaired glucose clearance, deficient pancreatic secretion of insulin and C-peptide, and elevated glucagon levels. Pancreatic islets in a diabetic chimpanzee were hypercellular, possible due to alpha-cells. Minimal or no insulin was observed in beta-cells. Results are consistent with the occurrence of noninsulin-dependent diabetes mellitus, which may be more prevalent in chimpanzees than heretofore suspected.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D005260:Female; D005951:Glucose Tolerance Test / Q000662:veterinary; D008297:Male; D002679:Pan troglodytes; D010179:Pancreas / Q000473:pathology
chemical_list: D001786:Blood Glucose