[Properties of influenza virus isolated from the bodies of mice at different stages of experimental influenza].
The results of the study of persistent influenza infection in S57BL mice developing after inoculation with influenza virus enriched with defective-interfering (DI) particles are presented. Regular isolation of the virus from lung tissues of the infected animals for 45 days after infection was observed. At later intervals after infection (2-8 months), the lungs and spleens yielded 8 virus strains differing from the original by their pathogenicity for mice, and thermostability of hemagglutinin. Examinations by gel electrophoresis of a strain isolated 6 months after inoculation revealed changes in the mobility of M and NS proteins which could produce some phenotypic changes of the virus in the course of persistent infection.
D000818:Animals; D003673:Defective Viruses; D004591:Electrophoresis, Polyacrylamide Gel; D006389:Hemagglutinins, Viral / Q000032:analysis; D009980:Influenza A virus / Q000302:isolation & purification*; D008168:Lung / Q000382:microbiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009439:Neuraminidase / Q000032:analysis; D009976:Orthomyxoviridae Infections / Q000382:microbiology*; D014762:Viral Interference; D014764:Viral Proteins / Q000302:isolation & purification
D006389:Hemagglutinins, Viral; D014764:Viral Proteins; D009439:Neuraminidase
Svoĭstva virusov grippa, vydelennykh iz organizma mysheĭ na raznykh stadiiakh éksperimental'noĭ grippoznoĭ infektsii.