title: Early effects of sodium iodate on the directly recorded standing potential of the eye and on the c-wave of the DC registered electroretinogram in albino rabbits.
abstract: The early effects of intravenously administered sodium iodate (NaIO3) on the directly recorded standing potential (SP) of the eye and on the c- and b-waves of the DC registered ERG were studied in 8 anaesthetized albino rabbits. In 5 of 6 animals obtaining 40 mg NaIO3/kg bwt. the SP decreased immediately following the injection, and had attained a level 3.5 - 4 mV below the original one after 1 h. The c-wave declined rapidly and 6 min after the injection it was replaced by a large cornea-negative potential. The b-wave was relatively unchanged except in one animal. In 2 rabbits treated with 30 mg NaIO3/kg btw. and in the 6th animal obtaining 40 mg NaIO3/kg bwt. an SP increase instead of a decrease was seen, and the c-wave was more slowly (about 22 min after the injection) replaced by the cornea-negative potential. The b-wave was somewhat increases. These results demonstrate the dose-related and inter-individual variability in the SP reaction to NaIO3 and are in good agreement with the well-known ultrastructural pigment epithelial injury and c-wave changes produced by this substance.
mesh_terms: D000818:Animals; D004596:Electroretinography; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D007452:Iodates / Q000494:pharmacology*; D007455:Iodine / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D007452:Iodates; D007455:Iodine