title: Further studies on the effect of fibrinopeptides A and B on the central nervous system.
abstract: Fibrinopeptides A and B (FAB) given intraperitoneally increased general activity of rats without affecting motor coordination. FAB depressed thiopental-induced sleeping time, prolonged the latency of pentetrazol convulsions, shortened the tonic phase of electrogenic convulsions. The peptides depressed the dopamine level in investigated brain areas of rats and increased the level of homovanillic acid. FAB accelerated the disappearance of dopamine after alpha-methyl-p-tyrosine injection. The data indicate tha FAB stimulate the central nervous system and this seems to be related to their interaction with the central dopaminergic system.
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D004597:Electroshock; D005340:Fibrinogen / Q000494:pharmacology*; D005344:Fibrinopeptide A / Q000494:pharmacology*; D005345:Fibrinopeptide B / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced; D013874:Thiopental / Q000494:pharmacology
chemical_list: D005344:Fibrinopeptide A; D005345:Fibrinopeptide B; D005340:Fibrinogen; D013874:Thiopental