title: [Study on radiosterilization of crude drug pill involving bezoar bovis--radiolysis of bilirubin and cholic acids in hydrous starch pellet (author's transl)].
abstract: Radiolysis of bilirubin and cholic acids (cholic acid, desoxycholic acid and lithocholic acid) in hydrous pellet have been investigated with following parameters, which were hydrous content, radiation dose and the dose rate, to discuss the application of gamma-irradiation for sterilization of crude drug pill involving bezoar bovis. At 774 C/kg (3.0 MR) irradiation for 5% and 10% hydrous contents pellets, the radiolysis percent of those components were less than 5%. However, the higher hydrous pellet, the radiolysis percents of those are more increase. At the same irradiated condition for 20% hydrous contents pellets, the radiolysis percents of those were 15-22%. The hydrous percent of commercial crude drug pill involving bezoar bovis are about 9%, so that the radiolysis of those components will be less than 5% on the sterilization. The radiolysis percent of bilirubin are constant to variation of radiation dose rate between 51.6-722.5 C/kg.hr (0.2-2.8 MR/hr). But, the values of cholic acids don't definite such as that of bilirubin, because of larger analytical error.
mesh_terms: D000818:Animals; D001663:Bilirubin / Q000528:radiation effects*; D002793:Cholic Acids / Q000528:radiation effects*; D004304:Dosage Forms; D004307:Dose-Response Relationship, Radiation; D004340:Drug Contamination; D005720:Gamma Rays; D008516:Medicine, Chinese Traditional; D008518:Medicine, East Asian Traditional; D011829:Radiation Dosage; D013242:Sterilization; D014867:Water / Q000032:analysis
chemical_list: D002793:Cholic Acids; D004304:Dosage Forms; D014867:Water; D001663:Bilirubin