Experimental study on the inhibition of kinin release in endotoxin shock by glutathione, proteinase inhibitors, hydrocortisone and hyperbaric oxygen.
Glutathione, proteinase inhibitors, steroids and hyperbaric oxygen are significantly effective to improve the survival of rats and to inhibit the liberation of plasma kinin in endotoxin shock. The combination of those anti-shock agents resulted in a decrease of kinin release in endotoxin shock in contrast with the treatment with each agent alone.
D000818:Animals; D005978:Glutathione / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology*; D006931:Hyperbaric Oxygenation; D007705:Kinins / Q000378:metabolism*; D011480:Protease Inhibitors / Q000494:pharmacology*; D051381:Rats; D012772:Shock, Septic / Q000188:drug therapy / Q000378:metabolism*
D007705:Kinins; D011480:Protease Inhibitors; D005978:Glutathione; D006854:Hydrocortisone