Met-enkephalin uptake by a synaptosome-enriched fraction of rat striatum.
We describe the accumulation of tritiated Met-enkephalin by a synaptosome-enriched fraction of rat striatum. Specificity of Met-enkephalin uptake was established by thin layer chromatography. This uptake process is dependent on substrate concentration and is inhibited by excess unlabeled peptide. It requires energy; it is inhibited by coincubation with ouabain.
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D004723:Endorphins / Q000378:metabolism*; D004744:Enkephalin, Methionine; D004745:Enkephalins / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013574:Synaptosomes / Q000378:metabolism*; D013696:Temperature; D014316:Tritium
D004723:Endorphins; D004745:Enkephalins; D014316:Tritium; D004744:Enkephalin, Methionine