The effect of sodium fluoride on experimental influenza virus infection in mice.
NaF was administered intranasally to mice, either as a single 0.1-ml dose (containing 100 gamma), one hour before inoculation of influenza virus A/PR8/34 (H0N1), or as four similar daily doses, the last drug application preceding virus inoculation by 1 hour. In both cases the drug treatment led to a marked reduction in the hemagglutinating titers recorded in lung suspensions, accompanied by a lower mortality percentage and by an increase in mean survival length.
D000818:Animals; D005459:Fluorides / Q000494:pharmacology*; D006386:Hemagglutination Tests; D009980:Influenza A virus / Q000187:drug effects / Q000472:pathogenicity*; D008168:Lung / Q000382:microbiology; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000382:microbiology* / Q000401:mortality; D012969:Sodium Fluoride / Q000494:pharmacology*
D012969:Sodium Fluoride; D005459:Fluorides