Practical problems in the use of Ocusert-pilocarpine delivery system.
The effects of the long-acting pilocarpine preparation, Ocusert, were studied by its application for one week into a total of 52 eyes of 42 earlier untreated glaucoma patients. From the diurnal pressure curves it was found to be equivalent to three daily administrations of 2 or 4% pilocarpine topically, the experiences were as follow: 8 of the preparations had to be removed before the end of the experiment due to insufficient effect and two were removed for other reasons; 19 fell out accidentally, 3 were displaced so as to be visible occasionally under the eyelid, but did not fall out; 2 patients succeeded in replacing the preparation after it had fallen out. In the 19 eyes (37%) of all patients still in the trial after the first day, the preparations stayed in place without any difficulty for the whole week. All patients experienced minor side-effects, but only one of them terminated the treatment due to these side-effects. Serious side-effects did not occur.
D000328:Adult; D000368:Aged; D003692:Delayed-Action Preparations; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D010862:Pilocarpine / Q000008:administration & dosage*
D003692:Delayed-Action Preparations; D009883:Ophthalmic Solutions; D010862:Pilocarpine