A transplantable human malignant Schwannoma.
A human malignant Schwannoma was serially transplanted through three generations in nude mice. The tumours grew readily and the take-up rate was 100 per cent. No metastasis was observed in nude mice. Morphological features of the original tumour were strictly maintained through all the transplant generations. The tumour cells of the original and of the transplants showed features of primitive Schwann cells of embryonic nerve trunks.
D000328:Adult; D000818:Animals; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008854:Microscopy, Electron; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D009442:Neurilemmoma / Q000473:pathology / Q000648:ultrastructure*; D014183:Transplantation, Heterologous