Effect of graded doses of secretin on parathormone serum levels in man.
5 healthy volunteers were submitted to i.v. infusion for 45 min of graded doses of commercial GIH secretin (0.01, 0.025, 0.05, 0.5, 1 and 2 CU/kg h-1). Parathormone serum levels were measured before and during the infusion. All the dosages of exogenous secretin were followed by a significant increase in serum PTH levels in a dose-dependent fashion. Commercial GIH secretin, even at low doses, seems to increase circulating parathyroid hormone levels significantly.
D004305:Dose-Response Relationship, Drug; D006801:Humans; D010280:Parathyroid Glands / Q000187:drug effects / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000097:blood*; D012633:Secretin / Q000008:administration & dosage* / Q000494:pharmacology
D010281:Parathyroid Hormone; D012633:Secretin