Antileukemic effects of 5-(2-dimethylaminoethoxy)-7-oxo-7H-benzo(c) fluorene, substance VUFB 13 468, on L1210 and La leukemia.
The antineoplastic effect of 5-(2-dimethyl-aminoethoxy)-7-oxo-7H-benzo(c) fluorene, substance VUFB 13 468, was studied in leukemia L1210 and leukemia La. It was found that the test substance, in the form of base and in the form of hydrochloride, influenced favorably the survival of leukemic mice, in which the life span increased in dependence on the dose and the scheme of its application.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D005449:Fluorenes / Q000627:therapeutic use*; D007939:Leukemia L1210 / Q000188:drug therapy; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D000970:Antineoplastic Agents; D005449:Fluorenes; C034234:VUFB 13468