title: A new hypothesis on memory - a possible role of local circuits in the formation of the memory trace.
abstract: An hypothesis is proposed arguing that local circuits might work as biochemical units involved in synthesis of macromolecules related to the memory processes. Specific sequences in the activation of local circuits should act as a "template" for the synthesis of particular memory molecules, which, in turn, may facilitate the repetition of the original sequences of bioelectrical signals (short-term memory). The resynthesis of the local memory molecules in cell body areas, their flow to terminal areas via axoplasmic transport and their possible passage to other nerve cells via transynaptic transport might be the basis of long term memory. The role of diffuse neuronal systems (e.g. noradrenaline systems) is discussed in the frame of memory recall and consolidation. The suggested hypothesis can be represented in a very effective way by means of the graph theory.
mesh_terms: D000818:Animals; D004594:Electrophysiology; D006801:Humans; D008568:Memory / Q000502:physiology*; D008570:Memory, Short-Term / Q000502:physiology; D011939:Mental Recall / Q000502:physiology; D008954:Models, Biological; D009474:Neurons / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology; D013569:Synapses / Q000502:physiology
chemical_list: D009638:Norepinephrine