Endothelial damage induced by polyethylene catheter in rat.
A method is described for obtaining endothelial lesions in the aorta by implanting polyethylene catheters in the aorta of rats for two days. Three types of lesions were observed and were quantified by measuring their lengths: (a) the simple disendothelization (b) raised lesions, and (c) tunnel lesions. The effect of a number of antiplatelet drugs on these types of lesions was investigated, and it was observed that these are particularly active in inhibiting tunnel lesions. Using this method, endothelial lesions can be obtained in a short period of time. Moreover, a large number of results can be obtained rapidly, which is important in these types of experiments due to the high dispersion obtained.
D000818:Animals; D001011:Aorta / Q000187:drug effects; D001161:Arteriosclerosis / Q000209:etiology*; D002404:Catheterization / Q000009:adverse effects*; D004195:Disease Models, Animal; D004727:Endothelium / Q000187:drug effects; D005260:Female; D010974:Platelet Aggregation / Q000187:drug effects; D011095:Polyethylenes; D051381:Rats; D011919:Rats, Inbred Strains; D013927:Thrombosis / Q000517:prevention & control
D011095:Polyethylenes