Structural alterations of liver parenchyma induced by anabolic steroids.
The long-term effects of an anabolic steroid (Dianabol) an the liver of motor-active mice was investigated. The pathologic changes occurring are due to cholestasis, peliosis hepatis, and diffuse hepatitis. It was assumed that a pathogenic relationship between cholestasis, peliosis, and cirrhosis exists. Neoplasms seldom occurred, but it was suggested that anabolic steroids do not primarily induce the formation of liver tumors.
D045930:Anabolic Agents / Q000494:pharmacology*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced; D004300:Doping in Sports; D005260:Female; D008099:Liver / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D008696:Methandrostenolone / Q000494:pharmacology; D008954:Models, Biological; D009115:Muridae; D010382:Peliosis Hepatis / Q000139:chemically induced
D045930:Anabolic Agents; D008696:Methandrostenolone