title: Skin reactions of rats to levamisole and D-penicillamine.
abstract: Levamisole and D-penicillamine are not skin sensitizers in rats. Furthermore, they do not stimulate T-lymphocyte proliferation in the draining lymph node when injected in oil into the hindpaw or base of the tail. Their copper coordination compounds also do not sensitize rats though they are irritant when injected locally.
mesh_terms: D000818:Animals; D004342:Drug Hypersensitivity; D005260:Female; D006968:Hypersensitivity, Delayed; D007428:Intradermal Tests; D007978:Levamisole / Q000276:immunology / Q000633:toxicity*; D008297:Male; D010396:Penicillamine / Q000276:immunology / Q000633:toxicity*; D051381:Rats; D012867:Skin / Q000187:drug effects* / Q000276:immunology
chemical_list: D007978:Levamisole; D010396:Penicillamine