[Breast cancer and use of antihypertensive drugs and oral contraceptives: results of a case-control study (author's transl)].
A case control study in breast cancer was conducted in France between 1976 and 1980. 1 031 patients with histologically confirmed cancer of the breast were entered into the study. Each was matched on age (+/- 5 years) to two controls hospitalized in the same clinic for a benign disease. We have specially studied the anti-hypertensive drugs, and the oral contraceptives. We found no difference between cancer patients and controls concerning their consumption of anti-hypertensive drugs, whether containing reserpine or not, and their consumption of oral contraceptives. However, there is a relation between the use of oral contraceptives and the age, family status and social class of women. After adjustment on these factors, we found a 1.62 relative risk of developing a cancer of the breast among the women using oral contraceptives (p less than 0.02).
D000328:Adult; D000959:Antihypertensive Agents / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000139:chemically induced*; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D003279:Contraceptives, Oral, Sequential / Q000009:adverse effects; D005260:Female; D006801:Humans; D012110:Reserpine / Q000009:adverse effects; D012306:Risk
D000959:Antihypertensive Agents; D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D003278:Contraceptives, Oral, Hormonal; D003279:Contraceptives, Oral, Sequential; D012110:Reserpine
Etude de la liaison entre le cancer du sein et la prise de médicaments hypotenseurs et contraceptifs oraux: résultats d'une étude cas-témoins.