Retinol esterification in lamb kidney.
Retinol esterification was demonstrated in vivo and in vitro in lamb kidney. Retinol labeled with hydrogen-3 injected into the renal artery of lambs appeared in the labeled retinyl ester fraction in the renal vein. Degree of tracer incorporation into retinyl esters increased with vitamin A intake. In homogenates, activity was concentrated in microsomes and enhanced fourfold by addition of adenosine 5'-triphosphate and coenzyme A to the incubation mixture. These findings suggest that the esterification is a function of fatty acyl coenzyme A:retinol acyl transferase. Renal esterification may play a role in retinol homeostasis.
D000818:Animals; D004951:Esterification; D005260:Female; D007269:Injections, Intra-Arterial; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D012077:Renal Artery; D012756:Sheep / Q000378:metabolism*; D014801:Vitamin A / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
D014801:Vitamin A