title: [Esophageal ulcers induced by doxycycline. Evaluation of 4 cases].
abstract: In this study we present four cases, three of them with endoscopic demonstration and the other one with clinical diagnose of esophageal ulcer induced by Doxicicline. None of the patients had previous reports of esophageal pathology. The symptoms of retroesternal pain and dysphagia appeared after the taking of capsules without any liquid. In three patients we effectuated Esophagoscopy; it showed the presence of esophagitis and ulceration and the biopsy taken from case ner. 2 showed necrotic epithelium with inflammatory exudate with predominance of linphositoes and eosinophilos. In all the cases the symptoms disappeared after a short period of time when the medication was suspended and they were treated with bland diet and hour alcalines. We conclude that this kind of medication, as if it is possible, haven't to be administered to patients with esophageal pathologies. On the other hand it must be recommended to administer this medication with an important quantity of liquid and a considerable period before bedtime; besides we suggest not to ingest the medication in decubitus position.
mesh_terms: D000328:Adult; D004318:Doxycycline / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D004935:Esophageal Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D004941:Esophagitis; D004945:Esophagoscopy; D005260:Female; D006801:Humans; D008297:Male; D014456:Ulcer / Q000139:chemically induced
chemical_list: D004318:Doxycycline
vernacular_title: Ulceras esofágicas inducidas por hiclato de doxiciclina. Evaluación de 4 casos.