[Changes in the enzymic activity of monooxygenase components of rat hepatocytes after administration of tilorone].
It is established that tilorone-hydrochloride, the antiviral agent, stimulating the interferon synthesis in the organism of animals under experiment inhibits monooxygenase reactions in the albino rat hepatocytes being administered in combination with phenobarbital and 20-methylcholanthrene. The tilorone effect on the N- and O-demethylase activity of the liver microsomes in vitro was studied. It is established that the rate of dimethylaniline N-demethylation and anisole O-demethylation in this case lowers considerably, the character of the kinetic curves being unchanged.
D000818:Animals; D005260:Female; D005449:Fluorenes / Q000494:pharmacology*; D007369:Interferon Inducers / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000187:drug effects; D008748:Methylcholanthrene / Q000494:pharmacology; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013994:Tilorone / Q000494:pharmacology*
D005449:Fluorenes; D007369:Interferon Inducers; D008748:Methylcholanthrene; D006899:Mixed Function Oxygenases; D013994:Tilorone; D010634:Phenobarbital
Izmenenie fermentativnoĭ aktivnosti komponentov monooksigenaz gepatotsitov krys pri vvedenii tilorona.