title: Studies on the influence of cysteine derivatives on the cell-mediated immunity.
abstract: The study concerns the effect of cysteine derivatives and its hydrazides on cell mediated immunity. Cysteine derivatives appeared to exert marked suppressive influence on development and course of post-adjuvant polyarthritis in rats. L-cysteine hydrazides prolonged skin allograft survival time in rats to higher degree than cysteine. The results of in vitro experiments point to the inhibition of the non-stimulated and stimulated PHA incorporation of 3H-thymidine by lymphocytes. It was observed that cysteine derivatives examined, and mainly its hydrazides, exert stronger than cysteine suppressive effect on cell mediated immune response.
mesh_terms: D000818:Animals; D001168:Arthritis / Q000276:immunology; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006087:Graft vs Host Reaction / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects*; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051381:Rats; D012882:Skin Tests; D013329:Structure-Activity Relationship
chemical_list: D003545:Cysteine