Impairment of effects of vasopressin on [1-14C]oleate metabolism in hepatocytes from obese (ob/ob) mice.
In hepatocytes from lean mice vasopressin decreased ketogenesis and increased 14CO2 production from [1-14C]oleate and glucose release; these effects were Ca2+-dependent. None of these effects of vasopressin were obtained with hepatocytes from obese (ob/ob) mice. Similarly, adrenaline did not increase 14CO2 production in these hepatocytes, but it stimulated glucose release. Possible reasons for the impairment of vasopressin action are discussed.
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008820:Mice, Obese / Q000378:metabolism*; D019301:Oleic Acid; D009829:Oleic Acids / Q000378:metabolism*
D009829:Oleic Acids; D001127:Arginine Vasopressin; D019301:Oleic Acid; D002118:Calcium; D004837:Epinephrine