A study on the noninvasive evaluation of coronary vasodilating drugs with Thallium-201 myocardial imagings.
To evaluate clinically the effects of coronary vasodilating drugs, isosorbide dinitrate (ISDN), dilazep (DL), and dipyridamole (DP), on the myocardial perfusion, quantitative analysis of Thallium-201 myocardial imagings was performed before and after their sublingual or oral administration in 17 patients with ischemic heart disease (IHD) and 9 normal volunteers. The ratio of total myocardial blood flow to cardiac output (TMBF/CO) and the ratio of ischemic regional myocardial blood flow to cardiac output(RMBF/CO) were calculated according to the indicator fractionation principle. The ratio of radio-activity of infarcted region to total myocardium (R/T) was also calculated to judge the degree of scintigraphic defect objectively. There were increases in TMBF/CO in 7 of 9 patients after ISDN, 4 of 5 patients after DL, and 2 of 6 patients after DP. Increases in RMBF/CO were observed in all patients studied after ISDN and DL, whereas in 2 of 6 patients after dipyridamole. Decreases both in RMBF/CO and R/T which suggest coronary steal phenomenon were observed in 4 of 6 patients after DP. The myocardial imaging technic is a useful noninvasive method for clinical evaluation of coronary vasodilating drug.
D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy; D002302:Cardiac Output / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000188:drug therapy*; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D004109:Dilazep / Q000627:therapeutic use; D004176:Dipyridamole / Q000627:therapeutic use; D006801:Humans; D007548:Isosorbide Dinitrate / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000188:drug therapy; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013793:Thallium; D014665:Vasodilator Agents / Q000627:therapeutic use*
D011868:Radioisotopes; D014665:Vasodilator Agents; D004176:Dipyridamole; D013793:Thallium; D004109:Dilazep; D007548:Isosorbide Dinitrate