title: Possible role of inorganic sulphate in the pathogenesis of hyperparathyroidism in chronic renal failure.
abstract: In order to investigate the role of hypersulphataemia in the development of hyperparathyroidism the blood levels of inorganic sulphate (SO4(2-)) and phosphate (HPO4(2-)) were compared with total and ionised calcium (Ca) and parathyroid hormone (PTH) in 20 patients with chronic renal failure (CRF). There was a positive correlation between plasma SO4(2-) and serum creatinine. Ionised Ca was inversely correlated with HPO4(2-), SO4(2-) and PTH, respectively. The best correlation was found between ionised Ca and the ion product of HPO4(2-) and SO4(2-). It is suggested that hypersulphataemia might be involved in the pathogenesis of secondary hyperparathyroidism and osteodystrophy in CRF by complex formation with Ca, thereby aggravating the effect of HPO4(2-) on ionised Ca and the resulting PTH stimulation.
mesh_terms: D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000097:blood; D002648:Child; D003404:Creatinine / Q000097:blood; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000097:blood / Q000209:etiology*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications*; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D013431:Sulfates / Q000097:blood*
chemical_list: D010281:Parathyroid Hormone; D010710:Phosphates; D013431:Sulfates; D003404:Creatinine; D002118:Calcium