[Actidione-cycloheximide and the route of intestinal absorption of lipids in the rat].
The effect of actidione-cycloheximide on the intestinal absorption of 14C oleic acid was studied on male rats using the ex vivo perfusion technique in control rats and those treated with a protein synthesis inhibitor. With the amounts of lipid infused, the radioactivity recovered in portal blood lipids was the same in treated rats and in controls. However, differences were observed in the appearance of oleic acid in the portal blood during the first 15 min. When protein synthesis was inhibited, absorption occurred earlier via the portal blood. The absorption balance in this type of experiment was considerably lower than normal absorption probably because or surgical stress. In conclusion, when esterification was impaired, oleic acid seemed to be absorbed via the portal blood at the beginning of the experiment like short or medium-chain fatty acids.
D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology*; D004951:Esterification; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000378:metabolism; D007700:Kinetics; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids / Q000097:blood / Q000378:metabolism*; D011169:Portal Vein; D051381:Rats; D011919:Rats, Inbred Strains
D009829:Oleic Acids; D019301:Oleic Acid; D003513:Cycloheximide
Actidione-cycloheximide et voie d'absorption intestinale des lipides chez le rat.