Disproportional loss of membrane constituents in the course of erythrocyte aging.
Acetylcholine esterase activity and sialic acid content were estimated in human erythrocytes separated according to their densities and after fragmentation in vitro by heating or a combined hyperosmolaric-mechanical stress. In vivo aged cells showed a disproportional loss of both membrane constituents. Fragmentation of erythrocytes in vitro resulted in a proportional loss of acetylcholine esterase activity and sialic acid. Young cells are more prone to fragmentation by heat than older ones.
D000110:Acetylcholinesterase / Q000097:blood; D002499:Centrifugation, Density Gradient; D004905:Erythrocyte Aging; D004910:Erythrocyte Membrane / Q000502:physiology*; D004912:Erythrocytes / Q000502:physiology*; D006801:Humans; D012794:Sialic Acids / Q000097:blood
D012794:Sialic Acids; D000110:Acetylcholinesterase