title: Effect of 2-mercaptoethanol on the haemagglutinating activity and antigenic properties of rubella virus.
abstract: Tween-ether treated rubella virus extract treated with 2-mercaptoethanol no longer haemagglutinates and its ability to combine with antibody is reduced although its sedimentation characteristics and the electrophoretic mobilities of the envelope glycoproteins are unaffected. The role of disulphide bonds in maintaining the structural and functional integrity of rubella virus is discussed.
mesh_terms: D000956:Antigens, Viral; D002499:Centrifugation, Density Gradient; D055598:Chemical Phenomena; D002621:Chemistry; D006023:Glycoproteins; D006387:Hemagglutination, Viral / Q000187:drug effects*; D008623:Mercaptoethanol / Q000494:pharmacology*; D012412:Rubella virus / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D014759:Viral Envelope Proteins; D014764:Viral Proteins
chemical_list: D000956:Antigens, Viral; D006023:Glycoproteins; D014759:Viral Envelope Proteins; D014764:Viral Proteins; D008623:Mercaptoethanol