title: Plasma and tissue concentrations of oxytetracycline in the horse after intravenous administration.
abstract: Oxytetracycline (OTC) was administered IV to 3 clinically normal horses at a dosage of 10 mg of OTC/kg of body weight. Plasma OTC concentrations were determined at 30-minute intervals until postinjection minute (PIM) 240. At PIM 240, the mean OTC concentration in pulmonary tissue was 3.96 microgram/g of tissue (wet weight) and in renal tissue was 25.47 micrograms/g. diluted bronchial fluid had a mean concentration of 0.288 microgram of OTC/ml at PIM 240. The data demonstrated that OTC has adequate tissue distribution in horses.
mesh_terms: D000818:Animals; D005260:Female; D006736:Horses / Q000378:metabolism*; D007275:Injections, Intravenous / Q000662:veterinary; D007668:Kidney / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D010118:Oxytetracycline / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
chemical_list: D010118:Oxytetracycline