title: [Immune response of mice to experimental influenza].
abstract: The immune response of BALB/c mice to a pathogenic and nonpathogenic strains of influenza type A virus was studied. In this system of experimental influenza infection the pathogenic influenza A/PR8/34 (HON1) virus was found to induce sensitization of T-lymphocytes and production of clones cytotoxic for syngeneic target cells. Nonpathogenic influenza A/Krasnodar/101/59 (H2N2) virus had a less marked capacity to induce sensitization of lymphocytes and production of clones cytotoxic for syngeneic target cells. But the nonpathogenic virus strain had a sufficiently high mitogenic activity and stimulated proliferation of lymphocytes sensitized by a heterogenous influenza virus strain.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D003601:Cytotoxicity Tests, Immunologic; D009980:Influenza A virus / Q000276:immunology / Q000472:pathogenicity; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology*; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D012137:Respiratory System / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral
vernacular_title: Immunnyĭ otvet u mysheĭ na éksperimental'nuiu grippoznuiu infektsiiu.