Amikacin sulfate levels in human serum and bile.
Amikacin levels in blood and bile were measured in 10 patients who underwent cholecystectomy and T-tube drainage. Each patient received 500 mg of amikacin intravenously 12 h preoperatively, during surgery, and every 12 h thereafter for four more doses. Average levels of amikacin in bile were 8.3 micrograms/ml at 1 h after the intraoperative dose, with a bile/serum ratio of 0.44. Postoperative doses at 1 h produced levels in bile of 3.8 to 4.2 micrograms/ml, with a bile/serum ratio of 0.15 to 0.22. Levels in bile decreased at a rate lower than levels in blood, and bile/serum ratios increased from 0.54 at 2 h to 0.93 at 12 h. Amikacin accumulated in bile at 6 h after the intravenous dose.
D000328:Adult; D000368:Aged; D000583:Amikacin / Q000097:blood / Q000378:metabolism*; D001646:Bile / Q000378:metabolism*; D002763:Cholecystectomy; D006801:Humans; D007612:Kanamycin / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D007612:Kanamycin; D000583:Amikacin