title: Cefuroxime therapy of gonorrhea and coinfection with Chlamydia trachomatis in children.
abstract: Twenty-seven episodes of gonorrhea occurring in children less than 15 years of age were treated with an intramuscular injection of cefuroxime, 25 mg/kg. Gonococci were eliminated from genital, pharyngeal, and anal sites in all cases. Cefuroxime was well tolerated and no side effects were observed. Coinfection with Chlamydia trachomatis was found in nine patients (33%). Among the seven patients with chlamydial genital infection, postgonococcal symptoms persisted in three children (43%). On patient of the five with chlamydial anal infections were successfully treated with trisulfapyrimidines.
mesh_terms: D000293:Adolescent; D001004:Anus Diseases / Q000382:microbiology; D002444:Cefuroxime / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002690:Chlamydia Infections / Q000150:complications* / Q000382:microbiology / Q000635:transmission; D002692:Chlamydia trachomatis; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy / Q000382:microbiology; D005832:Genital Diseases, Male / Q000188:drug therapy / Q000382:microbiology; D006069:Gonorrhea / Q000188:drug therapy* / Q000382:microbiology / Q000635:transmission; D006801:Humans; D007223:Infant; D008297:Male; D010608:Pharyngeal Diseases / Q000382:microbiology
chemical_list: D002511:Cephalosporins; D002444:Cefuroxime