A unique Y/Y translocation in an infertile male.
A monocentric and submetacentric Y/Y translocation without evidence of mosaicism was observed in a male with tall stature and azoospermia. Chromosome measurements of the abnormal Y of this patient and the normal Y of his father were undertaken to determine more precisely the chromosome break points in this translocation. The measurements failed to show a definite loss of chromatin from the original short arm of the proband's Y chromosome. The azoospermia and infertility in our patient, in contrast to his father, suggest that infertility may be associated with this specific Y/Y translocation in human males.
D000328:Adult; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D007621:Karyotyping; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D009030:Mosaicism; D012730:Sex Chromosomes / Q000648:ultrastructure*; D012867:Skin; D014178:Translocation, Genetic; D014998:Y Chromosome / Q000648:ultrastructure*