title: Serum concentration of pancreatic polypeptide after infusion of histamine and the effect of cimetidine, trimipramine, and atropine in man.
abstract: Histamine was given intravenously to eight human subjects, and the PP concentration in serum increased significantly from 14.8 (7.2-29.3) pM to 27.5 (9.6-39.3) pM and then decreased to the basal level. This histamine-induced PP release was not altered when trimipramine or cimetidine was given in addition to histamine. This PP release could not mediated through histamine-receptor mechanisms, and since atropine prevented this PP release, we conclude that the release of PP after histamine reflects a cholinergic stimulus.
mesh_terms: D000328:Adult; D001285:Atropine / Q000494:pharmacology*; D002927:Cimetidine / Q000494:pharmacology*; D003984:Dibenzazepines / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D010191:Pancreatic Polypeptide / Q000097:blood*; D013997:Time Factors; D014299:Trimipramine / Q000494:pharmacology*
chemical_list: D003984:Dibenzazepines; D006146:Guanidines; D010191:Pancreatic Polypeptide; D014299:Trimipramine; D001285:Atropine; D002927:Cimetidine; D006632:Histamine