Ocular toxocariasis presenting as leukocoria in a patient with low ELISA titer to Toxocara canis.
A 4-year-old white female presented with leukocoria of the right eye. White punctate lesions were observed posterior to the retrolental membrane, which suggested retinoblastoma of some examiners. A full history, physical examination, ultrasonography, and CT scan failed to rule the diagnosis of retinoblastoma in or out. A serum ELISA titer was 1:4, which was considered nondiagnostic. Examination of the enucleated eye revealed a midsegment of the second stage larva of Toxocara canis. The strengths and weaknesses of various diagnostic modalities used to differentiate leukocoria caused by retinoblastoma and T canis are discussed.
D000941:Antigens / Q000032:analysis*; D001196:Ascariasis / Q000175:diagnosis*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005128:Eye Diseases / Q000175:diagnosis* / Q000473:pathology; D005134:Eye Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D012175:Retinoblastoma / Q000175:diagnosis*; D014119:Toxocara / Q000276:immunology*; D014120:Toxocariasis / Q000175:diagnosis* / Q000473:pathology
D000941:Antigens