[Erythrocyte levels of ALA-dehydrase and uro-synthetase in chronic renal insufficiency (author's transl)].
Erythrocyte levels of ala-dehydrase and uro-synthetase as well as hematocrit, hemoglobin, iron levels and serum iron binding capacity were studied in a group of 28 patients with chronic renal failure in hemodialysis and compared to those of a control group. As is usual, hematocrit, hemoglobin an iron levels were significantly decreased, as were ala-dehydrase levels, while uro-synthetase levels were within normal levels. These results are interpreted as a blockade of the biosynthetic pathway of the protoporphyrins, which lends support to the hypothesis of an existing defect in hemoglobin synthesis in patients with chronic renal failure.
D000642:Ammonia-Lyases / Q000097:blood*; D004912:Erythrocytes / Q000201:enzymology*; D006454:Hemoglobins / Q000096:biosynthesis; D006801:Humans; D011163:Hydroxymethylbilane Synthase / Q000097:blood*; D007501:Iron / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000201:enzymology / Q000628:therapy; D000623:Porphobilinogen Synthase / Q000097:blood*; D006435:Renal Dialysis
D006454:Hemoglobins; D007501:Iron; D011163:Hydroxymethylbilane Synthase; D000623:Porphobilinogen Synthase; D000642:Ammonia-Lyases
Estudio de los niveles eritrocitarios de ala-dehidrasa y uro-sintetasa en la insuficiencia renal crónica.