Some pharmacological properties of tiopronin.
Tiopronin (50 mg/kg) and D-penicillamine (50 mg/kg) do not exhibit anti-inflammatory effects in classic animal models (carragenin oedema, granuloma cotton pellets) but suppress pertussis vaccine oedema, an immunological model, when given with a long-lasting dosing regime. Tiopronin and D-penicillamine also fail to inhibit PG release by phagocytosing leucocytes when the concentrations used were in the same range as human blood levels (5-15 micrograms/ml). Indomethacin (1, 3 and 5 mg/kg) instead significantly inhibits both the in vivo and in vitro models considered. This may imply a different mode of action of both tiopronin and D-penicillamine from indomethacin. Tiopronin also possesses similar effects to D-penicillamine suggesting that their overall anti-rheumatic action may have common elements.
D000603:Amino Acids, Sulfur / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents; D002351:Carrageenan; D004487:Edema / Q000188:drug therapy; D003368:Gossypium; D006099:Granuloma / Q000188:drug therapy; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D010396:Penicillamine / Q000494:pharmacology; D010567:Pertussis Vaccine; D011453:Prostaglandins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D008625:Tiopronin / Q000494:pharmacology*
D000603:Amino Acids, Sulfur; D000893:Anti-Inflammatory Agents; D010567:Pertussis Vaccine; D011453:Prostaglandins; D002351:Carrageenan; D008625:Tiopronin; D010396:Penicillamine