title: Circulating platelet aggregates: a chronic platelet activation in patients with transient ischaemic attacks.
abstract: Platelet hyperaggregability was tested in 62 TIA patients by means of the formalin fixing principle of Wu and Hoak. Compared to age-matched controls, the platelet aggregates ratio (PAR) was reduced from 0.99 +/- 0.04 SD to 0.807 +/- 0.14 SD. This means a highly significant increase of circulating platelet aggregates (CPA) in untreated TIA patients, regardless of the interval sinche the last attack (from 2 days to 1 year). PAR was especially reduced in patients with abnormal angiography (expressing pronounced cerebral or diffuse ATS) and it was possibly affected by previous antiplatelet treatment with ASA.
mesh_terms: D001241:Aspirin / Q000627:therapeutic use*; D002533:Cerebral Angiography; D004176:Dipyridamole / Q000627:therapeutic use*; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000097:blood; D002546:Ischemic Attack, Transient / Q000097:blood* / Q000517:prevention & control; D008875:Middle Aged; D010974:Platelet Aggregation
chemical_list: D004176:Dipyridamole; D001241:Aspirin