Antagonistic activity of galanthamine on constant infusion of pancuronium in rats.
The effect of galanthamine, an anticholinesterase having a tertiary ammonium group, on a constant infusion of pancuronium was studied in the rat tibialis anterior-sciatic nerve preparation. The results were compared with those previously obtained with neostigmine, pyridostigmine, and 4-aminopyridine. The antagonizing activity of galanthamine is similar to that of 4-aminopyridine and less than that of the other 2 anticholinesterases. The duration of galanthamine antagonism is similar to that of neostigmine and pyridostigmine but less than that of 4-aminopyridine.
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D004336:Drug Antagonism; D005702:Galantamine / Q000494:pharmacology*; D008297:Male; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D010197:Pancuronium / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000187:drug effects / Q000502:physiology*
D002800:Cholinesterase Inhibitors; D005702:Galantamine; D010197:Pancuronium