Comparison of the hydroxylation of benzo(a)pyrene with the metabolism of vinyl chloride, N-nitrosomorpholine, and N-nitroso-N'-methylpiperazine to mutagens by human and rat liver microsomal fractions.
D000328:Adult; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism; D001580:Benzopyrenes / Q000378:metabolism*; D001711:Biotransformation; D005260:Female; D006801:Humans; D006900:Hydroxylation; D066298:In Vitro Techniques; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D009025:Morpholines / Q000378:metabolism*; D009153:Mutagens / Q000378:metabolism*; D009602:Nitrosamines / Q000378:metabolism*; D010879:Piperazines / Q000378:metabolism*; D051381:Rats; D014752:Vinyl Chloride / Q000378:metabolism*; D014753:Vinyl Compounds / Q000378:metabolism*
D001580:Benzopyrenes; D009025:Morpholines; D009153:Mutagens; D009602:Nitrosamines; D010879:Piperazines; D014753:Vinyl Compounds; C002741:N-nitrosomorpholine; C014710:N-nitroso-N'-methylpiperazine; D008748:Methylcholanthrene; D001189:Aryl Hydrocarbon Hydroxylases; D014752:Vinyl Chloride