[Is glycosylated haemoglobin subject to rapid variations? Changes in insulin-dependent diabetic patients under a 24-hour artificial pancreas treatment (author's transl)].
According to recent studies, glycosylated haemoglobin (HbA1) is subject to rapid variations. In order to verify this point, nine insulin-dependent diabetic patients underwent a 24-hour normalization of glycaemia with an artificial pancreas. There was a non-significant decrease of HbA1 from 9.26 +/- 1.03 p. cent to 8.69 +/- 0.84 p. cent (mean +/- s.d.). An explanation to the apparent discrepancies between the different studies is proposed. The variations observed could largely be due to the inclusion or non inclusion in the assay methods of a subfraction of glycosylated haemoglobin: a Schiff's base likely to undergo glysosylation in a rapidly reversible manner.
D003920:Diabetes Mellitus / Q000097:blood*; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D007332:Insulin Infusion Systems; D013997:Time Factors
D006442:Glycated Hemoglobin
L'hémoglobine glycosylée est-elle susceptible de fluctuations rapides? Evolution chez 9 diabétiques insulinodépendants traités pendant 24 h par pancréas artificiel.