title: Decrease in effects of muscimol on the dorsal root after repeated administration of diazepam in rats.
abstract: In in situ experiments on spinal rats transected at the C1 level and on non-spinal rats, muscimol (3 mg/kg, i.v.) depolarized the primary afferent fibers and diazepam (3 mg/kg, i.v.) potentiated this effect of muscimol. When diazepam was given for 14 days, the effect of muscimol was significantly reduced in non-spinal rats. These findings suggest that diazepam probably interacts with GABA-ergic mechanisms more closely in supraspinal regions of the rat.
mesh_terms: D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009118:Muscimol / Q000037:antagonists & inhibitors*; D010080:Oxazoles / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D013126:Spinal Nerve Roots / Q000187:drug effects*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000502:physiology
chemical_list: D010080:Oxazoles; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D003975:Diazepam; D001640:Bicuculline