[Age related changes in the pharmacodynamics and pharmacokinetics of digoxin (author's transl)].
Studies have been carried out on some peculiarities of the pharmacodynamics and pharmaco-kinetics in clinically healthy elderly and aged persons. It has been demonstrated that an increase in the sensitivity of the myocardium to digitoxin, and a decrease of its excretion by the kidneys are factors promoting the development of glycoside intoxication in the aged.
D000328:Adult; D000368:Aged; D000375:Aging; D004077:Digoxin / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D008875:Middle Aged
D004077:Digoxin
Altersabhängige Veränderungen der Pharmakodynamik und der Pharmakokinetik des Digoxins.