The influence of sodium selenite on tumor induction by methylnitrosourea (MNU) in rats.
The effect of sodium selenite on tumor induction by MNU was studied in 3 groups of 40 WE rats each. Group I received 10 intraperitoneal injections of 20 mg/kg b. w. MNU in intervals of 4 weeks and beginning with the 1st administration 4 ppm sodium selenite in the drinking water. Rats of group II and III were given only MNU or selenite, respectively. A slight but statistically not significant increase of tumors was found in group I as compared with group II. In group III tumors did not occur. Problems of the anticarcinogenic action of sodium selenite and other antioxidants are discussed.
D000818:Animals; D005260:Female; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000517:prevention & control; D008770:Methylnitrosourea; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D020887:Selenious Acid; D012643:Selenium / Q000627:therapeutic use*
D008770:Methylnitrosourea; D020887:Selenious Acid; D012643:Selenium