[Influence of nephrectomy on the antihypertensive effects of propranolol in the dog (author's transl)].
1. The effect of bilateral nephrectomy (24 hours before) on the antihypertensive action of dl-propranolol (1 mg/kg iv) was studied in acute neurogenic hypertensive dogs. 2. Bilateral nephrectomy induced an increase in plasma urea and creatinine, a decrease in protein values but did not change the other plasma values (table I). 3. Propranolol always induced a decrease in blood pressure (fig. 1) and heart rate (fig. 2) in bilateral nephrectomized dogs. 4. These results suggest that renal mechanisms (especially modifications of renin release) did not play a predominant or exclusive role in the antihypertensive action of beta-blocking agents under our experimental conditions.
D000818:Animals; D003714:Denervation; D003971:Diastole / Q000187:drug effects; D004285:Dogs; D004573:Electrolytes / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy*; D007668:Kidney / Q000502:physiology; D008297:Male; D009392:Nephrectomy; D011433:Propranolol / Q000627:therapeutic use*; D013599:Systole / Q000187:drug effects; D014508:Urea / Q000097:blood
D004573:Electrolytes; D014508:Urea; D011433:Propranolol
Conséquence de la néphrectomie sur les effets antihypertenseurs du propranolol chez le chien.