[DNA metabolism of synovial cells in chronic polyarthritis after intra-articular administration of prednisolone].
In 8 patients with rheumatoid arthritis the influence of intra-articular (i.a.) injections of prednisolone-21 -acetate on the DNA metabolism of synovial fluid cells was examined. Two hours after an i.a. injection of 25 mg prednisolone acetate a significant decrease of the sedimentation of nucleoids was found. After a 60 minute incubation the sedimentation of nucleoids became normal. An inhibition of DNA repair by 25 mg prednisolone acetate could not be demonstrated.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004247:DNA / Q000378:metabolism*; D004260:DNA Repair / Q000187:drug effects; D006801:Humans; D007270:Injections, Intra-Articular; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D013583:Synovial Membrane / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D004247:DNA; D011239:Prednisolone
Untersuchungen über den DNA-Metabolismus der Synovialiszellen bei chronischer Polyarthritis nach intraatikulärer Prednisolon-Applikation.