Platelet-derived growth factor (PDGF) enhances the growth of Moloney sarcoma virus-induced tumors in mice.
The intramuscular (i.m.) administration of bovine or human platelet derived growth factor (PDGF) had a marked potentiating effect on the growth of Moloney sarcoma virus (MSV)-induced tumors in Balb/c mice. PDGF had the tumor-promoting-activity when administered i.m. on the side of inoculation of MSV two days after the virus, and subsequently every second day for 2-3 weeks. The extent of MSV-induced tumor promoting activity of PDGF was age and sex-related. In view of the recently described antagonism in action between growth factors and interferons it is suggested that both families of hormones play an important role in controlling the neoplastic proliferation.
D000375:Aging; D000818:Animals; D002417:Cattle; D002455:Cell Division; D005260:Female; D006133:Growth Substances / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008934:Mitogens / Q000494:pharmacology*; D008979:Moloney murine leukemia virus; D009365:Neoplasm Regression, Spontaneous; D010455:Peptides / Q000494:pharmacology*; D010982:Platelet-Derived Growth Factor; D012513:Sarcoma, Experimental / Q000473:pathology*; D012737:Sex Factors
D006133:Growth Substances; D008934:Mitogens; D010455:Peptides; D010982:Platelet-Derived Growth Factor