Efficacy of narasin against hepatic and intestinal coccidiosis in rabbits.
The anticoccidial effect of narasin against Eimeria flavescens, E. intestinalis, E. magna, E. perforans and E. stiedai was tested in experimentally infected rabbits. The drug was highly effective in reducing oocyst output and in preventing clinical signs. Maximum activity as measured by oocyst discharge was achieved with feed levels from 12 to 24 p.p.m.; there was no influence on oocyst sporulation. Optimal weight gain and food consumption were obtained with levels between 8 and 12 p.p.m.; at higher levels there was an adverse effect on growth, food intake, relative liver and heart weights and on serum potassium and glucose.
D000821:Animal Feed; D000818:Animals; D001835:Body Weight; D003048:Coccidiosis / Q000188:drug therapy / Q000662:veterinary*; D003049:Coccidiostats / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004539:Eimeria / Q000187:drug effects / Q000254:growth & development; D009929:Organ Size; D011714:Pyrans / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D011817:Rabbits
D003049:Coccidiostats; D011714:Pyrans; C013612:narasin