Drug-polymer combinations. Part 1: The preparation of sustained release drugs by combination with ion exchanging resins.
The preparation of procainamide and propranolol resinates is described. By in vivo experiments with propranolol resinate as model substance the release rate as a function of crosslinking degree and particle size is studied. An in vitro test is carried out to compare the performance as prolonged release preparation of a resinate, e.g. procainamide resinate, with the action of the pure drug and of a Durette formulation.
D003692:Delayed-Action Preparations; D007475:Ion Exchange Resins; D007700:Kinetics; D011342:Procainamide / Q000008:administration & dosage; D011433:Propranolol / Q000008:administration & dosage
D003692:Delayed-Action Preparations; D007475:Ion Exchange Resins; D011433:Propranolol; D011342:Procainamide