title: Clinical progression of giant-axonal neuropathy over a twelve year period.
abstract: Giant-axonal neuropathy (GAN), a chronic peripheral neuropathy with associated Central Nervous System dysfunction and tight curly hair, is described in a 17-year-old girl. Biopsies of this girl's muscle and nerve are characteristic of this condition. Her clinical course over a 12 year period characterizes a disease of a slowly progressive nature.
mesh_terms: D001369:Axons / Q000473:pathology* / Q000648:ultrastructure; D001706:Biopsy; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008264:Macrophages / Q000473:pathology; D009132:Muscles / Q000473:pathology; D009422:Nervous System Diseases / Q000473:pathology* / Q000503:physiopathology; D013497:Sural Nerve / Q000473:pathology; D013997:Time Factors