Angiotoxic effects of dietary 7-ketocholesterol in chick aorta.
Although dietary 1-ketocholesterol treatment had little effect on plasma and liver lipid metabolism, aortas from chickens treated with 7-ketocholesterol contained numerous dead and dying smooth muscle cells. Chicks receiving dietary cholesterol, in amounts equal to or greater than the amount of 7-ketocholesterol, did not demonstrate significant smooth muscle cell degeneration. After eight weeks, a combined diet of 1% cholesterol plus 10-20 mg/day 1-ketocholesterol produced no larger amounts of aortic lipid deposition, and no greater increases in smooth muscle cell degeneration than a comparable group receiving 7-ketocholesterol alone. The abdominal aorta was always more severely damaged than the ascending arch or thoracic aorta in chicks fed 7-ketocholesterol. The results demonstrate a potent angiotoxic effect of 7-ketocholesterol.
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000648:ultrastructure*; D001012:Aorta, Abdominal / Q000648:ultrastructure; D001013:Aorta, Thoracic / Q000648:ultrastructure; D001161:Arteriosclerosis / Q000209:etiology* / Q000473:pathology; D002645:Chickens; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood; D002791:Cholesterol, Dietary / Q000009:adverse effects*; D005260:Female; D007653:Ketocholesterols / Q000009:adverse effects*; D008099:Liver / Q000032:analysis; D009131:Muscle, Smooth, Vascular / Q000648:ultrastructure; D010743:Phospholipids / Q000032:analysis / Q000097:blood; D014280:Triglycerides / Q000032:analysis / Q000097:blood
D002791:Cholesterol, Dietary; D007653:Ketocholesterols; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol; C003001:7-ketocholesterol