Alkylation and peroxidation injury from chemically reactive metabolites.
D000082:Acetaminophen / Q000378:metabolism / Q000633:toxicity; D000111:Acetylcysteine / Q000494:pharmacology; D000478:Alkylation; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001711:Biotransformation; D064420:Drug-Related Side Effects and Adverse Reactions; D005978:Glutathione / Q000031:analogs & derivatives / Q000378:metabolism; D019803:Glutathione Disulfide; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008862:Microsomes, Liver / Q000378:metabolism; D010545:Peroxides / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D008054:Lipid Peroxides; D010545:Peroxides; D004364:Pharmaceutical Preparations; D014810:Vitamin E; D000082:Acetaminophen; D005978:Glutathione; D019803:Glutathione Disulfide; D000111:Acetylcysteine