[State of guinea pig peripheral blood and bone marrow cells in phenol poisoning].
Blood tests and examination of bone marrow in 2-3 week guinea pigs under conditions of a long-term phenol intoxication (0.5 mg/kg perorally) showed the presence of thrombocytopenia and eosinophilia in peripheral blood and a decrease of the erythroblast maturation index in bone marrow. In the experiment with animals treated with a high dose of phenol there was an evidence of thrombocytopenia accompanied by reticulocytosis and a nuclear shift of neutrophils to the right. Erythroblast maturation index in bone marrow increase (the immature forms are quite probable to be formed due to ineffective division).
D000818:Animals; D001773:Blood Cells / Q000187:drug effects*; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006410:Hematopoiesis / Q000187:drug effects; D010636:Phenols / Q000506:poisoning*
D010636:Phenols
Sostoianie kletok perifericheskoĭ krovi i kostnogo mozga morskikh svinok pri fenol'noĭ intoksikatsii.