Relationship between ketogenesis and gluconeogenesis in isolated hepatocytes from newborn rats.
In hepatocytes from 1-day-old rats, active gluconeogenesis occurs in parallel with active ketogenesis, although the carbon atoms of non-esterified fatty acids do not participate in glucose synthesis. Once a significant ketogenesis is established, a further increase does not enhance gluconeogenesis. Indeed, octanoate is more ketogenic than oleate, but stimulates gluconeogenesis to a similar extent.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002469:Cell Separation; D005943:Gluconeogenesis; D007657:Ketone Bodies / Q000096:biosynthesis*; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D007657:Ketone Bodies