[The bioavailability of trapidil from suppositories (author's transl)].
In a study with five healthy persons designed to compare the bioavailability of Trapidil from Rosupol U suppositories with that from Witepsol H 15 suppositories, the availability of Trapidil from the Rosupol U suppositories was inferior in four of the five test subjects. The difference in the amounts of released drug observed in vivo was smaller than that found in vitro.
D000328:Adult; D001682:Biological Availability; D001835:Body Weight; D005079:Excipients; D006801:Humans; D011743:Pyrimidines / Q000378:metabolism*; D013488:Suppositories; D014192:Trapidil / Q000008:administration & dosage / Q000378:metabolism*
D005079:Excipients; D011743:Pyrimidines; D013488:Suppositories; D014192:Trapidil
Bioverfügbarkeit von Trapidil aus Suppositorien.