[Genesis of microcytes in hemodialysis patients with chronic uremia].
The study is concerned with factors that may reduce the life time of erythrocytes of patients under intermittent haemodialysis. The red cell population of these patients consisted of micro-, normo-, macro- and megalocytes. The classification of the cell size was shiftet to greater diameters in comparison with healthy donors. The evaluation of the biological half time of erythrocytes labelled with 51Cr resulted in a decrease of about 16 days. The autoradiographic evaluation of the erythrocyte size-distribution patterns 1 and 24 hours after the injection of labelled red cells into the donors circulation clearly demonstrated a decrease of macro- and megalocytes. Simultaneously, the number of microcytes rose considerably. The measurement of erythrocyte deformability could demonstrate a clearcut relationship of flexibility for a) disturbed erythropoiesis resulting in the production of macro- and megalocytes, and b) fragmentation and premature elimination from the circulation due to unfavourable rheologic properties of erythrocytes of abnormal big and small sizes.
D001345:Autoradiography; D002908:Chronic Disease; D004905:Erythrocyte Aging; D004909:Erythrocyte Indices; D004913:Erythrocytes, Abnormal / Q000166:cytology; D004920:Erythropoiesis; D006801:Humans; D007074:Immunoglobulin G; D011971:Receptors, Immunologic; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood*
D007074:Immunoglobulin G; D011971:Receptors, Immunologic
Untersuchungen zur Genese von Mikrocyten bei Hämodialysepatienten mit chronischer Urämie.