Hormonal regulation of chymotrypsin-like esteroproteases in the mouse submandibular gland.
The activities of chymotrypsin-like esteroproteases in the mouse submandibular gland were additively induced by 5 alpha-dihydrotestosterone (DHT) and triiodothyronine (T3). Zymograms showed that there are many isozymes whose activities are regulated by DHT and/or T3. Some isozymes seemed to be hormone-independent. Histochemical studies revealed that all these isozymes are localized in the granular convoluted tubules.
D000818:Animals; D002918:Chymotrypsin / Q000096:biosynthesis*; D013196:Dihydrotestosterone / Q000494:pharmacology*; D004790:Enzyme Induction; D005260:Female; D006651:Histocytochemistry; D007527:Isoenzymes / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013363:Submandibular Gland / Q000187:drug effects / Q000201:enzymology*; D014284:Triiodothyronine / Q000494:pharmacology*
D007527:Isoenzymes; D014284:Triiodothyronine; D013196:Dihydrotestosterone; D002918:Chymotrypsin