In vivo demonstration of endogenous substances regulating the regression of the acute inflammation.
Subcutaneous injection of Sephadex G 200 causes an acute inflammation in rats. Its course was estimated by the types and numbers of white cells which immigrated into the Sephadex implants during a period of 5 days. Adrenaline (ADR) as well as Isoproterenol (ISO) each alter the cell immigration in a characteristic pattern. Sephadex which has already induced inflammation in an animal causes a mitigated inflammatory process when transplanted to another animal. Sephadex originating from donor animals influenced by ADR or ISO causes different reactions. A comparison of the results of the original inflammatory response and of the transplantation experiments demonstrates that several distinct substances with apparently specific functions must participate in the regression of the acute inflammation. The process by which the acute inflammation subsides is controlled by the organism's endogenous antiinflammatory substances.
D000208:Acute Disease; D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D004804:Eosinophils / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology; D007249:Inflammation / Q000097:blood*; D007545:Isoproterenol / Q000494:pharmacology; D007958:Leukocyte Count; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D009504:Neutrophils / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D007545:Isoproterenol; D004837:Epinephrine