The molecular electrostatic potential and steric accessibility of poly (dI.dC). Comparison with poly (dG.dC).
The influence of the amino group of guanine on the molecular electrostatic potential and the accessibility to reactive sites of B-DNA is investigated by comparing the two model double helices poly (dI.dC) and poly (dG.dC). The calculations clarify the "disruptive" role of the guanine amino group on nucleic acid-polypeptide interactions.
D000494:Allosteric Regulation; D000900:Anti-Bacterial Agents; D004563:Electrochemistry; D006147:Guanine; D008956:Models, Chemical; D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D011089:Polydeoxyribonucleotides; D013816:Thermodynamics
D000900:Anti-Bacterial Agents; D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D011089:Polydeoxyribonucleotides; C031156:poly d(I-C); C019530:poly(dC-dG); D006147:Guanine