Study of antiulcer activity of aqueous extract of leaves of Pyrenacantha staudtii (family Icacinaceae) using various models of experimental gastric ulcer in rats.
The antiulcer activity of an aqueous extract of Pyrenacantha staudtii was studied in rats and was compared with that of cimetidine. Ulcers were induced in rats by means of various experimental models: aspirin, indomethacin, serotonin and reserpine. The extract was found to have significant antiulcer activity against all the models studied. Cimetidine was found to be ineffective against serotonin- and reserpine-induced ulcers.
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001241:Aspirin; D004195:Disease Models, Animal; D005260:Female; D007213:Indomethacin; D008297:Male; D009549:Nigeria; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine; D012701:Serotonin; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D012701:Serotonin; D012110:Reserpine; D001241:Aspirin; D007213:Indomethacin