Catabolism of desialylated glycoproteins during carcinogenesis and inflammation in rats.
Experiments were performed on rats injected with a malignant hepatoma (evoked by aflatoxin B1) or with inflammation induced by turpentine injection. On the 4th or 8th day after the injection, the following determinations were made: concentration of seromucoid, haptoglobin, sialic acid and fucose in blood serum; binding of asialo-glycoproteins by liver extracts; elimination of asialo-[125I]haptoglobin and asialo-[125I]orosomucoid from circulation. It was found that hepatoma and inflammation affected neither the activity of liver receptors for asialo-glycoproteins, nor the rate of asialo-glycoprotein elimination from circulation.
D000818:Animals; D001212:Asialoglycoproteins; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D006242:Haptoglobins / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000378:metabolism; D008297:Male; D009369:Neoplasms / Q000378:metabolism*; D009961:Orosomucoid / Q000378:metabolism; D051381:Rats
D001212:Asialoglycoproteins; D006023:Glycoproteins; D006242:Haptoglobins; D009961:Orosomucoid