[Buprenorphine and nicomorphine in a double-blind trial for the control of postoperative pain (author's transl)].
Analgesic effects as well as side effects, circulatory and respiratory parameters of 0.3 mg Buprenorphine (Temgesic) were compared to 10 mg Nicomorphine (Vilan) intramuscularly injected in a double-blind, randomized study for the relief of postoperative pain. Buprenorphine produced an equally potent but longer acting analgesic effect compared to Nicomorphine, although slight delayed. There were only few and slight side effects and no influence on the circulation and the respiration. In the search for a new long-acting and strong analgesic Buprenorphine proved to be superior to Nicomorphine in the control of postoperative pain.
D000328:Adult; D002047:Buprenorphine / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D009019:Morphinans / Q000627:therapeutic use*; D009022:Morphine Derivatives / Q000009:adverse effects / Q000627:therapeutic use*; D009539:Nicotinic Acids / Q000009:adverse effects / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy*
D009019:Morphinans; D009022:Morphine Derivatives; D009539:Nicotinic Acids; D002047:Buprenorphine; C008549:nicomorphine
Buprenorphin und nicomorphin im klinischen Doppelblindversuch zur postoperativen Schmerzbekämpfung.