Platelet adhesion onto sulfonated artificial red blood cells.
Rabbit hemolysate-loaded microcapsules having sulfonic acid groups on their surface were prepared and rabbit platelet adhesion onto the sulfonated surface was examined kinetically. Rabbit platelets adhered more markedly onto the surface of a higher charge density than that of a lower one, indicating a trend similar to that found in the case of the surface having carboxyl groups. Moreover, the platelets were found to be stickier in the buffer solution than in the plasma, though the dependence of platelet adhesion in the buffer solution on the magnitude of surface charge of the sulfonated artificial red blood cells was still recognized.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001081:Apyrase / Q000494:pharmacology; D001802:Blood Substitutes / Q000494:pharmacology*; D006454:Hemoglobins / Q000494:pharmacology*; D006461:Hemolysis; D007700:Kinetics; D009757:Nylons / Q000494:pharmacology*; D010973:Platelet Adhesiveness / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits
D001802:Blood Substitutes; D006454:Hemoglobins; D009757:Nylons; C030235:poly(N(alpha),N(epsilon) L-lysinediylterephthaloyl)hemolysate capsules; D000244:Adenosine Diphosphate; D001081:Apyrase