title: Comparative structure and chemistry of tubulins from different eukaryotes.
abstract: Electrophoretic and peptide mapping have been used to examine alpha- and beta-tubulins from chordates, tunicates, echinoderms, mollusks, brachiopods, ferns, fungi, green algae and heliozoans. Cytoplasmic, ciliary, flagellar, and axopodial tubulins were examined. The results show that beta-tubulin is more conserved than alpha-tubulin. The large differences seen between axonemal and cytoplasmic tubulins and the similarity of all axonemal tubulins examined indicate that the genes for these two tubulin classes diverged prior to the appearance of metazoa and metaphyta. Comparisons of alpha-tubulins appear useful for tracing phyletic relationship within kingdoms whereas comparisons of beta-tubulins may be better for relating the kingdoms to each other.
mesh_terms: D000818:Animals; D005075:Biological Evolution; D046911:Macromolecular Substances; D010446:Peptide Fragments / Q000032:analysis; D013045:Species Specificity; D014404:Tubulin
chemical_list: D046911:Macromolecular Substances; D010446:Peptide Fragments; D014404:Tubulin