Effects of beta-(Tyr9)melanotropin-(9-18) decapeptide on passive and active avoidance behavior and on open-field activity of rats.
The effects of the administration of beta-(Tyr9)melanotropin-(9-18) into the lateral ventricle in a dose of 1.0 micrograms in 2 microliters were studied on passive avoidance behavior, extinction of active avoidance behavior, and open-field activity in rats. beta-(Tyr9) melanotropin-(9-18) given 30 min pretrial facilitated the acquisition of passive avoidance behavior; however, it was ineffective on retention when the material was given immediately posttrial or 30 min before retention testing. The extinction of active behavior was delayed. In open-field activity, the ambulation rate and rearing activity were increased 30 min following administration. The data suggest that beta-(Tyr9)melanotropin-(9-18) has distinct neurotropic properties, and is able to modify behavioral reactions.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects*; D006120:Grooming / Q000187:drug effects; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats
D009842:Oligopeptides; D010446:Peptide Fragments; C033533:MSH, beta, (9-18), Tyr(9)-; D009074:Melanocyte-Stimulating Hormones