Effect of unilateral nephrectomy in rabbits on pharmacokinetics of salicylate.
The pharmacokinetics of salicylate was investigated in rabbits 6 months after unilateral nephrectomy. Sodium salicylate was given through the stomach gauge once in a dose of 20 mg/kg. Pharmacokinetic calculations assuming one compartment open model have revealed that in nephrectomized rabbits area under the curve (AUC) was increased by 131%, t0.5 was prolonged from 4.46 to 5.78 h, and kel was diminished by 40%. The plasma creatinine level remained unchanged and the remaining kidney was increased by 68%.
D000818:Animals; D003404:Creatinine / Q000097:blood; D005260:Female; D007700:Kinetics; D008297:Male; D009392:Nephrectomy; D011817:Rabbits; D012459:Salicylates / Q000378:metabolism*
D012459:Salicylates; D003404:Creatinine