title: [Effect of age on induction of intestinal tumors in mice by 1,2-dimethylhydrazine].
abstract: 1,2-Dimethylhydrazine was administered subcutaneously in a dose of 8 mg/kg bw to 2-, 8- and 12-month-old female CBA mice for 25 weeks. The animals were serially killed 26-35 weeks after the beginning of treatment. The incidence of colon tumors in 2-month-old mice was always significantly lower (P less than 0.001) than in 8- or 12-month-old mice. The incidence of tumors with invasive growth in 12-month-old mice was significantly higher (P less than 0.05) than in 8-month-old mice. Mathematical evaluation allowed the conclusion about the 1.8-fold shortening of the colon tumor latency period in old mice as compared to the young mice.
mesh_terms: D019813:1,2-Dimethylhydrazine; D000367:Age Factors; D000818:Animals; D002273:Carcinogens; D004127:Dimethylhydrazines / Q000378:metabolism; D007414:Intestinal Neoplasms / Q000139:chemically induced*; D007420:Intestine, Large / Q000378:metabolism; D008763:Methylhydrazines; D051379:Mice; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000139:chemically induced; D013997:Time Factors
chemical_list: D002273:Carcinogens; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D019813:1,2-Dimethylhydrazine
vernacular_title: Vliianie vozrasta na induktsiiu 1,2-dimetilgidrazinom opukholeĭ kishechnika u mysheĭ.