Inhibition of the hepatocarcinogenic activity of diethylnitrosamine (DENA) by ethanol in rats.
Male Sprague-Dawley rats received 0.1 mg/kg of diethyl-nitrosamine orally five times a week for life with or without additional subsequent administration of 5 ml/rat/day of a 25% aqueous solution of ethanol. The additional treatment with ethanol significantly reduced the induction of liver cancer, but not of esophageal tumors. These findings do not support speculations based on epidemiologic studies as to a cancer-causing effect of alcohol.
D000818:Animals; D004052:Diethylnitrosamine / Q000037:antagonists & inhibitors*; D004938:Esophageal Neoplasms / Q000139:chemically induced*; D000431:Ethanol / Q000494:pharmacology*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains
D009602:Nitrosamines; D004052:Diethylnitrosamine; D000431:Ethanol