[Changes in plasma volume and electrolytes after treatment of therapy-resistant hypertension with diazoxide and furosemide].
10 patients (5 females, 5 males, average age 50.2 +/- 5.8 years) with a therapy-resistant hypertension were for 10 days treated with injections of diazoxide and furosemide (hypertonalum and furesis). A significant decrease of the blood pressure as well as a decrease of sodium and potassium in the serum occurred, where as the electrolyte content of te 24-hour collection urine was influenced in homogeneously. The blood and plasma volume, respectively, was also significantly reduced. Heart rate and blood sugar significantly increased, urea-N, creatinine, hematocrit and hemoglobin did not increase significantly. The new regulation of the blood pressure to an oral antihypertensive permanent therapy continued 4 weeks to 6 months.
D001786:Blood Glucose / Q000032:analysis; D003981:Diazoxide / Q000627:therapeutic use*; D005260:Female; D005665:Furosemide / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D008297:Male; D008875:Middle Aged; D010953:Plasma Volume / Q000187:drug effects*; D011188:Potassium / Q000097:blood / Q000652:urine; D012964:Sodium / Q000097:blood / Q000652:urine
D001786:Blood Glucose; D005665:Furosemide; D012964:Sodium; D003981:Diazoxide; D011188:Potassium
Die Veränderungen von Plasmavolumen und Elektrolyten nach der Behandlung der therapieresistenten Hypetonie mit Diazoxid und Furosemid.