Intrahepatic cholestasis induced by phenylbutazone.
The case history of a woman with intrahepatic cholestasis is described. She had taken phenylbutazone during 1 month for painful swollen knees. A liver biopsy obtained at surgical exploration revealed pericentral cholestasis and infiltration of the portal spaces with lymphocytes and eosinophilic leucocytes, suggesting a drug reaction. Clinical and biochemical parameters returned to normal within 2 months. A provocation test with a single dose of phenylbutazone was performed 6 months after her recovery. On the 2nd day, a marked increase of serum transaminases and alkaline phosphatase was observed. Transaminases became normal within several days, whereas alkaline phosphatase remained elevated during a month. From these data we conclude that phenylbutazone can cause cholestatic jaundice probably as a result of a hypersensitivity reaction.
D002780:Cholestasis, Intrahepatic / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects; D010653:Phenylbutazone / Q000009:adverse effects*
D010653:Phenylbutazone