The effect of lonetyl on the electroencephalogram and rheoencephalogram of experimental animals.
In view of the interesting problem of the correlation between the functional cerebral activity and cerebral blood circulation, as well as the controversy in the literature concerning the effects of tranquilizers on cerebral blood circulation, the effects of the daily tranquilizer Lonetyl on the spontaneous cerebral bioelectrical activity and cerebral haemodynamics have been studied. According to rheoencephalographic data, Lonetyl is found to reduce cerebral vascular tone, which is manifested by decreased values of the relative share and the dicrotic index, the maximum effect being observed between the 15th and 30th min. The changes in the EEG consist in significant increase of the alpha- and theta-activity, with maximum effect on the 15th min, increased mean frequency and decreased mean amplitude. Synchronization of the cerebral bioelectrical activity is observed after the 30th min.
D000818:Animals; D001921:Brain / Q000502:physiology*; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004569:Electroencephalography; D008702:Methaqualone / Q000031:analogs & derivatives* / Q000494:pharmacology; D010992:Plethysmography, Impedance; D014149:Tranquilizing Agents / Q000494:pharmacology*
D014149:Tranquilizing Agents; C012409:lonetil M3; D008702:Methaqualone