The control of male fertility by 6-chloro-6-deoxysugars.
1. 6-Chloro-6-deoxyglucose (24 mg/kg/day) produces a rapid and reversible antifertility effect in the male rat but high doses (greater than 200 mg/kg/day) produce spermatocoeles. In the mouse repeated high doses (480 mg/kg/day) cause paralysis of the hind limbs but there is no effect on fertility. 2. Spermatozoa from rats treated with 6-chloro-6-deoxyglucose (24 mg/kg/day) are unable to metabolize glucose and rapidly become exhausted when glucose is the only substrate supplied. Glycolysis is inhibited at the glyceraldehyde 3-phosphate dehydrogenase reaction. These spermatozoa can obtain energy by oxidizing pyruvate or lactate. 3. The side effects prevent the use of 6-chloro-6-deoxyglucose by humans but a fuller understanding of their mode of action may lead to the development of compounds with a more selective attack on spermatozoa.
D000818:Animals; D003272:Contraceptive Agents, Male / Q000494:pharmacology; D006224:Cricetinae; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005298:Fertility / Q000187:drug effects*; D005947:Glucose / Q000378:metabolism; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors; D006019:Glycolysis / Q000187:drug effects; D007700:Kinetics; D008297:Male; D051379:Mice; D010243:Paralysis / Q000139:chemically induced; D051381:Rats; D013088:Spermatocele / Q000139:chemically induced; D013094:Spermatozoa / Q000187:drug effects* / Q000378:metabolism
D003272:Contraceptive Agents, Male; D003837:Deoxy Sugars; C021163:6-chloro-6-deoxyglucose; D003847:Deoxyglucose; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D005947:Glucose