title: [Effect of remantadine, ribavirin and their combinations on the protein synthesis of influenza virus A in a cell culture].
abstract: Simultaneous use of ribavirin (I-beta-D-ribofuranosyl-1,2,4-triazol-3-carboxamide and rimantadine (alpha-methyl-I-adamantane methylamine HCL) was shown to effect most distinctly on protein synthesis in influenza virus A in the system studied as compared with the separate action of each of the drugs. Ribavirine inhibited the protein synthesis in rimantadine-resistant strain of influenza virus A.
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives*; D000818:Animals; D002642:Chick Embryo; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D009980:Influenza A virus / Q000187:drug effects* / Q000378:metabolism; D012254:Ribavirin / Q000494:pharmacology*; D012263:Ribonucleosides / Q000494:pharmacology*; D012299:Rimantadine / Q000494:pharmacology*; D014764:Viral Proteins / Q000096:biosynthesis*; D014776:Virus Cultivation
chemical_list: D012263:Ribonucleosides; D014764:Viral Proteins; D012299:Rimantadine; D012254:Ribavirin; D000218:Adamantane
vernacular_title: Vliianie remantadina, ribvirina i ikh kombinatsiĭ na sintez belkov virusa grippa A v kul'ture kletok.