title: Iodothyronines and thyrotrophin in serum after jejunoileostomy with 3:1 or 1:3 jejunoileal ratio.
abstract: Serum levels of thyroxine (T4), 3,3',5-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3) and thyrotrophin, and T3-uptake were measured in 13 morbidly obese patients preoperatively and during the first five months after jejunoileal bypass surgery, in which period the patients lost 20% in body weight. They were randomized to a ratio of 3:1 or 1:3 between the jejunal and ileal segment included in the bypass, but the results in the two groups did not differ significantly. T4 level showed a slight decrease during the five months after surgery. T3 level was reduced to 82% of the preoperative value within the first month of surgery, and was stable thereafter. rT3 level was unaffected by surgery, as was the level of thyrotrophin. T3-uptake increased slightly after surgery. These findings are compatible with caloric restriction with low carbohydrate intake, and suggests that disruption of the enterohepatic circulation of iodothyronines is without clinical importance.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007082:Ileum / Q000601:surgery*; D007583:Jejunum / Q000601:surgery*; D008297:Male; D009765:Obesity / Q000097:blood / Q000628:therapy*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*; D013997:Time Factors; D014284:Triiodothyronine / Q000097:blood; D014285:Triiodothyronine, Reverse / Q000097:blood
chemical_list: D014284:Triiodothyronine; D014285:Triiodothyronine, Reverse; D013972:Thyrotropin; D013974:Thyroxine