Delayed elimination of fibrin from the lungs in rats given alpha 2-antiplasmin.
Injection of human alpha 2-antiplasmin resulted in delayed elimination of fibrin from the lungs in rats with thrombin-induced intravascular coagulation. The amount of alpha 2-antiplasmin injected was chosen so as to simulate the posttraumatic increase of this inhibitor in man. By injecting trace amounts only of radiolabelled alpha 2- antiplasmin a specific uptake of this protein in the lungs was noted after the thrombin-induced coagulation. The results may indicate that the posttraumatic increase in alpha 2-antiplasmin is of significance for the delayed elimination of fibrin seen in patients following trauma.
D000818:Animals; D004211:Disseminated Intravascular Coagulation / Q000503:physiopathology; D005337:Fibrin / Q000378:metabolism*; D008168:Lung / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D051381:Rats; D012128:Respiratory Distress Syndrome / Q000503:physiopathology*; D000979:alpha-2-Antiplasmin / Q000494:pharmacology*
D000979:alpha-2-Antiplasmin; D005337:Fibrin