Measurement of blood flow and vascular permeability changes in response to 12-O-tetradecanoyl-phorbol-13-acetate and to asbestos fibers.
The hyperemia (increased blood flow) and vascular permeability changes induced in rabbit skin by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate and by asbestos fibers have been quantitated. The resultant hyperemia, measured with radiolabeled microspheres, was inhibited in both cases by steroidal and nonsteroidal anti-inflammatory drugs. Since the inflammatory responses resulting from exposure to these agents might be important for the subsequent development of neoplasms, it is proposed that such a specific and quantitative technique be used to analyze the components of these inflammatory responses in more detail.
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001194:Asbestos / Q000009:adverse effects*; D002199:Capillary Permeability / Q000187:drug effects*; D006940:Hyperemia / Q000139:chemically induced / Q000209:etiology*; D007700:Kinetics; D010704:Phorbols / Q000633:toxicity*; D011817:Rabbits; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*
D000893:Anti-Inflammatory Agents; D010704:Phorbols; D001194:Asbestos; D013755:Tetradecanoylphorbol Acetate