title: Catch-up growth.
abstract: Catch-up growth, defined as growth velocity above the statistical limits of normality for age or maturity during a defined period of time, is distinguished from compensatory growth since it makes up for a potential loss rather than an actual loss and is seen in the whole body as opposed to specific organs. The cellular explanation for catch-up based on the work of Winick is described and a recent challenge to this explanation is briefly discussed. The mechanism of mismatch between actual size and 'planned' size suggested by Tanner is described and tested. In a series of experiments conducted in rats of different ages the degree of mismatch and the role of catch-up are compared for two different parameters, body weight and nose-rump length. It was found that the two parameters behaved differently and it is suggested that while the concept of mismatch is still acceptable the idea of a single central mechanism is not supported. It is suggested that the mismatch mechanism is a cellular phenomenon.
mesh_terms: D000375:Aging; D000818:Animals; D000833:Animals, Suckling; D001699:Biometry; D001835:Body Weight; D002455:Cell Division; D005260:Female; D005508:Food Deprivation / Q000502:physiology; D006128:Growth; D007700:Kinetics; D008297:Male; D051381:Rats; D012737:Sex Factors