title: [Pantothenic acid biotransformation in human vitamin deficiency].
abstract: Content of CoA and pantothenic acid in leukocytes as well as excretion of the vitamin derivatives, estimated by microbiological procedure, with urine with 6 and 24 hrs after administration per os or intramuscularly of 200 mg calcium pantothenate were studied in 42 donors and 25 patients with chronic alcoholism. In all the cases content of CoA of the pantothenate metabolites were increased in leukocytes within 6 hrs after the vitamin loading. Excretion of pantothenic acid and its derivatives with urine was increased for a short time in healthy persons after loading, however its total content maintained similar to normal values within 24 hrs. In the patients with chronic alcoholism the increase in concentrations of the components studied in leukocytes was accompanied by a distinct increase in excretion of the vitamin with urine within 24 hrs.
mesh_terms: D000328:Adult; D000430:Alcohol Withdrawal Delirium / Q000378:metabolism; D000437:Alcoholism / Q000378:metabolism; D001711:Biotransformation; D003065:Coenzyme A / Q000378:metabolism; D005260:Female; D005609:Free Radicals; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010205:Pantothenic Acid / Q000008:administration & dosage / Q000172:deficiency / Q000378:metabolism*; D013375:Substance Withdrawal Syndrome / Q000378:metabolism; D013997:Time Factors
chemical_list: D005609:Free Radicals; D010205:Pantothenic Acid; D003065:Coenzyme A
vernacular_title: Biotransformatsiia pantotenovoĭ kisloty v usloviiakh vitaminnoĭ nedostatochnosti u cheloveka.