title: Craviten hydrolysis in plasma in vitro.
abstract: Craviten hydrolysis in vitro was studied in human, rat and canine plasma and erythrocytes. Craviten was degraded during the incubation with plasma and the hydrolysis was inhibited by trimethoxybenzoic acid, a metabolite of Craviten. Erythrocyte enzymes do not participate in the hydrolysis.
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000378:metabolism; D005029:Ethylenediamines / Q000097:blood*; D005707:Gallic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D006207:Half-Life; D006868:Hydrolysis; D066298:In Vitro Techniques; D007700:Kinetics; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005029:Ethylenediamines; C030706:butobendin; D005707:Gallic Acid; C005854:3,4,5-trimethoxybenzoic acid