title: Effects of catalase, peroxidase, superoxide dismutase and 10 scavengers of oxygen radicals in carrageenin edema and in adjuvant arthritis of rats.
abstract: Catalase, peroxidase and superoxide dismutase were found to inhibit significantly carrageenin edema and the primary phase of adjuvant arthritis in rats after i.v. injection. Heat-inactivated enzymes were as effective as the native enzymes. None of 10 scavengers of oxygen radicals inhibited the adjuvant arthritis at any time. Accordingly, no evidence for a participation of oxygen radicals in the secondary arthritis phase could be found, whereas a role of oxygen radicals in the primary arthritis phase and in carrageenin edema cannot be ruled out.
mesh_terms: D000818:Animals; D001168:Arthritis / Q000517:prevention & control*; D001169:Arthritis, Experimental / Q000517:prevention & control*; D002351:Carrageenan; D002374:Catalase / Q000627:therapeutic use*; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D005609:Free Radicals; D006735:Horseradish Peroxidase / Q000627:therapeutic use*; D010100:Oxygen; D010544:Peroxidases / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000627:therapeutic use*
chemical_list: D005609:Free Radicals; D002351:Carrageenan; D006735:Horseradish Peroxidase; D010544:Peroxidases; D002374:Catalase; D013482:Superoxide Dismutase; D010100:Oxygen