Glucuronide formation in the metabolism of N-substituted aryl compounds.
N-Glucuronide conjugates of N-arylhydroxylamines and O-glucuronides of N-acetyl-N-arylhydroxylamines may play significant roles in the extrahepatic carcinogenicity of arylamines by serving as stable transport forms of metabolically activated precursors. In extrahepatic target organs, these glucuronides can undergo pH-dependent hydrolytic reactions to liberate an activated metabolite or one capable of being further activated.
D000818:Animals; D001711:Biotransformation; D006224:Cricetinae; D005260:Female; D005965:Glucuronates / Q000378:metabolism*; D006168:Guinea Pigs; D006881:Hydroxyacetylaminofluorene / Q000378:metabolism; D006898:Hydroxylamines / Q000378:metabolism*; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013329:Structure-Activity Relationship
D005965:Glucuronates; D006898:Hydroxylamines; D006881:Hydroxyacetylaminofluorene