Development of means to augment peritoneal urea clearances: the synergistic effects of combining high dialysate temperature and high dialysate flow rates with dextrose and nitroprusside.
By combining: a) nitroprusside (4.5 mg/L); b) dextrose concentration of 42.5 gm/L; c) dialysate temperature of 42 degrees C and  d) dialysate flow rates of 3.5 L/hour in seven uremic subjects on CAPD, it was possible to increase peritoneal urea clearance up to 35.6 +/- 3.8 ml/min/1.73 m2 (range 30.3 to 42.2). This effect in six out of seven cases was associated with a fall in blood pressure and an increase in heart rate. This study is the first which deals with a combination of these factors and demonstrates that this approach is easy to handle, does not require the use of mechanical devices, and is available at any bedside.
D000328:Adult; D001794:Blood Pressure; D005260:Female; D005292:Ferricyanides / Q000627:therapeutic use*; D005947:Glucose / Q000627:therapeutic use*; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009599:Nitroprusside / Q000627:therapeutic use*; D010530:Peritoneal Dialysis / Q000379:methods*; D013696:Temperature; D014508:Urea / Q000378:metabolism*
D005292:Ferricyanides; D009599:Nitroprusside; D014508:Urea; D005947:Glucose