Toxicity and mutagenicity of hymenoxon, sequiterpene lactone.
The oral LD50 of hymenoxon in Swiss white mice was found to be 241 +/- 37 mg/kg. No significant sex differences were observed. Pretreatment of male mice for 3 days using doses of 50 and 100 mg/kg hymenoxon failed to alter significantly pentobarbital sleeping time. Hymenoxon was found to be a direct-acting mutagen in the Salmonella/mammalian microsome test. Urine samples obtained from hymenoxon-treated mice were found to be negative activity when tested directly and when incubated with beta-glucuronidase. Hymenoxon did not produce lethal DNA damage as measured in the Escherichia coli polA or Bacillus subtilis recombinational assays.
D000818:Animals; D004269:DNA, Bacterial / Q000378:metabolism; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D010424:Pentobarbital / Q000494:pharmacology; D010947:Plants, Toxic; D012717:Sesquiterpenes / Q000633:toxicity*; D012890:Sleep / Q000187:drug effects
D004269:DNA, Bacterial; D009153:Mutagens; D012717:Sesquiterpenes; C015288:hymenovin; D010424:Pentobarbital