In vitro activity of thienamycin.
The in vitro activity of thienamycin was determined simultaneously in Müller-Hinton broth and peptone broth. Minimum inhibitory and bactericidal concentrations were compared to those of 4 aminoglycosides and 3 cefalosporins. The activity of thienamycin against gram-negative aerobic bacterial was influenced by the media. Peptone broth gave the lowest MICs and MBCs. Concentrations less than or equal to 8 mcg thienamycin/ml peptone broth inhibited 354 out of 382 strains tested.
D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002511:Cephalosporins / Q000494:pharmacology; D007769:Lactams / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013845:Thienamycins
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D007769:Lactams; D013845:Thienamycins; C015537:thienamycin