title: The effect of progesterone on RNA polymerases in the rat uterus.
abstract: The effect of progesterone on transcription was investigated in the uterus of the ovariectomized rat. Progesterone rapidly depressed both RNA polymerase A and B activities for up to 6 h after steroid administration. Both enzyme activities returned to control values 24 h after steroid treatment. In contrast, in the estrogen-primed rat uterus, progesterone was capable of stimulating RNA polymerase B activity 30 min after hormone treatment. The cellular entities or mechanisms which progesterone uses to alter transcription in cell nucleus remain to be determined.
mesh_terms: D000818:Animals; D002369:Castration; D002467:Cell Nucleus / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors*; D005260:Female; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014544:Uridine Triphosphate / Q000378:metabolism; D014599:Uterus / Q000187:drug effects / Q000201:enzymology*
chemical_list: D011374:Progesterone; D012321:DNA-Directed RNA Polymerases; D014544:Uridine Triphosphate