Intestinal absorption of nutrients in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Impairment of active intestinal absorption of glucose and leucine was observed in rats 2-3 wk after oral treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (5 and 100 mg/kg). At the higher dose level used this response was complicated by the effects of severely reduced food consumption. Malabsorption of specific nutrients may help occasion the body wasting seen in many animals after acute exposure to TCDD.
D000818:Animals; D004147:Dioxins / Q000633:toxicity*; D004435:Eating / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects*; D007930:Leucine / Q000378:metabolism; D008297:Male; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D007930:Leucine; D005947:Glucose