Explanation of the effects of imidazole, aminopyrine, and thiocyanate on gastric secretion.
On the basis of the model of figure 9 and its equivalent circuit of figure 10, explanations have been presented for the inhibition of the SCN type of inhibitors and the reversal of their inhibition by the weak bases, imidazole and aminopyrine. On the basis of the model, we have presented explanations for the changes in PD and resistance associated with the SCN type of inhibitors. Explanations of the other effects of the SCN type inhibitors and the effects of the weak bases are possible on the basis of the model. However, these explanations involve some lengthy analysis beyond the scope of the present paper. The model supplies the conceptual basis for a considerable number of further substantive experiments.
D000632:Aminopyrine / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000502:physiology; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000494:pharmacology*; D008954:Models, Biological; D013861:Thiocyanates / Q000494:pharmacology*
D007093:Imidazoles; D013861:Thiocyanates; D000632:Aminopyrine