[Analgesic effect of clopheline].
Clophelin significantly decreases the intensity of behavioral and hemodynamic manifestations of nociceptive reactions and inhibits spontaneous behavior only in doses exerting a powerful hypotensive action in normotensive unrestrained cats (0.02-0.03 mg/kg) and rats (2-4 mg/kg). A similar correlation between the inhibition of nociceptive reactions and hypotension was revealed in experiments with papaverine (5-8 mg/kg). Naloxone averts the clopheline-induced hypotension and inhibition of the emotional and behavioral manifestations rather than recovers the hemodynamic nociceptive reactions. It is assumed that clophelin has no genuine morphine-like analgetic action.
D000700:Analgesics; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002415:Cats; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology*; D004347:Drug Interactions; D006439:Hemodynamics / Q000187:drug effects; D009270:Naloxone / Q000008:administration & dosage; D010146:Pain / Q000188:drug therapy; D010208:Papaverine / Q000008:administration & dosage; D051381:Rats
D000700:Analgesics; D009270:Naloxone; D010208:Papaverine; D003000:Clonidine
K voprosu ob anal'geticheskom éffekte klofelina.