Hypoglycemic activity of polypeptide-p from a plant source.
A hypoglycemic peptide, Polypeptide-p, has been isolated from fruit, seeds, and tissue of Momordica charantia  Linn (bitter gourd). Amino acid analysis indicates a minimum molecular weight of approximately 11,000 (166 residues). Polypeptide-p is a very effective hypoglycemic agent when administered subcutaneously to gerbils, langurs, and humans.
D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002520:Cercopithecidae; D003460:Crystallization; D003920:Diabetes Mellitus / Q000188:drug therapy; D004589:Electrophoresis, Disc; D005260:Female; D005849:Gerbillinae; D006801:Humans; D007004:Hypoglycemic Agents / Q000302:isolation & purification* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009699:N-Glycosyl Hydrolases; D010940:Plant Proteins / Q000302:isolation & purification*; D010946:Plants, Medicinal / Q000737:chemistry*; D054790:Ribosome Inactivating Proteins, Type 2
D000596:Amino Acids; D007004:Hypoglycemic Agents; D010940:Plant Proteins; D054790:Ribosome Inactivating Proteins, Type 2; D009699:N-Glycosyl Hydrolases