Participation of the beta-ketoadipate transport system in chemotaxis.
beta-Ketoadipate serves as a chemoattractant for Pseudomonas putida. The chemotactic response is inducible, and a regulatory mutant strain that forms the beta-ketoadipate transport system at high levels exhibits a heightened chemotactic response to beta-ketoadipate. Adipate and succinate, compounds that interact with the transport system, inhibit chemotaxis toward beta-ketoadipate. Some, but not all, mutants that fail to respond chemotactically to beta-ketoadipate lack the beta-ketoadipate transport system. It thus appears that the transport of beta-ketoadipate is associated with its function as a chemoattractant. It is likely that the metabolite attracts fluorescent Pseudomonas species to environments in which complex aromatic polymers undergo microbial dissimilation.
D000272:Adipates / Q000378:metabolism* / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D002633:Chemotaxis; D009154:Mutation; D011549:Pseudomonas / Q000166:cytology / Q000235:genetics / Q000378:metabolism*; D013386:Succinates / Q000494:pharmacology; D019802:Succinic Acid
D000272:Adipates; D013386:Succinates; C027316:3-oxoadipic acid; C029900:adipic acid; D019802:Succinic Acid