The influence of glutathione on the photoreaction of 3,4',5-tribromosalicylanilide alone and in the presence of serum albumin.
Glutathione is known to play a prominent detoxifying role in the organism. In this study attention has been paid to the possible occurrence of a detoxifying action of glutathione on the photoreaction of 3,4',5-tribromosalicylanilide (tbsa), which is notorious for causing photoallergy. It was found that tbsa forms stable photoconjugates on irradiation with glutathione: 3-glutathyl-4',5-dibromosalicylanilide and 5-glutathyl-4'-bromosalicylanilide. The rate of the photoreaction of tbsa in the presence of glutathione, resulting in photostable products, is increased. Furthermore, covalent binding with serum albumin appeared to be decreased in the presence of glutathione.
D005978:Glutathione / Q000494:pharmacology*; D010777:Photochemistry; D011485:Protein Binding / Q000187:drug effects / Q000528:radiation effects; D012457:Salicylamides / Q000378:metabolism*; D012458:Salicylanilides / Q000378:metabolism* / Q000528:radiation effects; D012710:Serum Albumin, Bovine / Q000378:metabolism*
D012457:Salicylamides; D012458:Salicylanilides; D012710:Serum Albumin, Bovine; C004361:tribromsalan; D005978:Glutathione