title: The capacity of testicular cells of the postnatal rat to reorganize into histotypic structures.
abstract: Cell reorganization experiments in vitro were performed with dissociated rat testes at different ages of postnatal development namely, newborn, 8-10, 18-25, 35-40, and 90 days. Only newborn and juvenile rat testicular cells reassociated into testicular-like organization in rotation culture. Puberal and adult rat testicular cells show morphogenetic organization when they were deprived or germ cells by busulphan pretreatment. A factor present in testicular tissue of puberal and adult rats inhibits reorganization. The inhibitor is confined to the spermatic cell fraction in the testis.
mesh_terms: D000375:Aging; D000818:Animals; D002066:Busulfan / Q000494:pharmacology; D002478:Cells, Cultured; D005260:Female; D008297:Male; D009024:Morphogenesis / Q000187:drug effects; D010053:Ovary / Q000166:cytology / Q000502:physiology; D051381:Rats; D013737:Testis / Q000033:anatomy & histology / Q000166:cytology / Q000254:growth & development*
chemical_list: D002066:Busulfan