Effect of butylated hydroxytoluene on the lipid composition of rat liver.
Hepatic lipids were studied in Sprague-Dawley male rats given butylated hydroxytoluene(BHT) at a level of 1.20% for 1 week. BHT significantly increased cholesteryl esters and phospholipids but decreased triglycerides, non-esterified fatty acids and diglycerides. BHT also increased phosphatidylethanolamine or decreased phosphatidylinositol and lysophosphatidylcholine. Fatty acid composition of each lipid class was also changed by BHT-feeding. The decrease in 16 : 1/16 : 0, 18 1/18 : 0 and 20 : 4/18 :2 ratios of total lipids, non-esterified fatty acids or phospholipids of BHT-given rats suggests that BHT decreases the activity of fatty acid desaturase in the liver.
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000633:toxicity*; D002788:Cholesterol Esters / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism
D002788:Cholesterol Esters; D005227:Fatty Acids; D010743:Phospholipids; D014280:Triglycerides; D002084:Butylated Hydroxytoluene