Murine immune memory to a TI-2 antigen, DNP-Ficoll: carrier-specificity, genetic enhancement and phenotypic dominant inheritance.
C3H/HeN x NZB/BIN F1 mice were primed and challenged with DNP-Ficoll, a thymic independent (TI-2) antigen. They developed strong IgM and IgG carrier-specific memory responses: DNP-pneumococcal polysaccharide or DNP-haemocyanin challenge did not elicit memory responses. The IgG response component appeared to be inherited dominantly from the C3H/HeN parent. The IgM component resulted from genetic enhancement.
D000818:Animals; D000955:Antigens, T-Independent / Q000276:immunology*; D004136:Dinitrobenzenes / Q000276:immunology; D005260:Female; D005362:Ficoll / Q000276:immunology; D005799:Genes, Dominant; D006823:Hybrid Vigor; D007074:Immunoglobulin G / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology*; D007156:Immunologic Memory; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H / Q000235:genetics; D008814:Mice, Inbred NZB / Q000235:genetics
D000955:Antigens, T-Independent; D004136:Dinitrobenzenes; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005362:Ficoll