[Effect of body weight reduction on platelet function and serum lipoproteins in obese children (author's transl)].
In 11 obese children aged 11,9 +/- 1,3 years total cholesterol (C), triglycerides (TG), HDL-C, LDL-C and apolipoprotein B (Apo B) were estimated in serum after 3 weeks of hypocaloric diet (800 kcal, kJ). In vitro platelet function was evaluated using the tests of ADP-induced aggregation and platelet sensitivity to prostacyclin. The in vivo platelet activity was judged by estimating plasma levels of beta-thromboglobuline (beta-TG) and platelet factor 4 (PF4). A mean weight loss of 5,7 +/- 1,8 kg was observed. Before diet, serum-C, TG and lipoprotein-C concentrations were found to be within the so called "normal range". After three weeks of diet we observed a significant decrease of total-C, which could be accounted for by a decline in the atherogenic LDL-C; furthermore Apo B levels significantly decreased. Concerning the tests of platelet function only for beta-TG and PF 4 a marked decline (to about 50% of the initial values) could be seen. These preliminary results and changes in the lipoprotein are discussed in connection with a possible reduction of the risk for the development of atherosclerotic lesions.
D000293:Adolescent; D001792:Blood Platelets; D001835:Body Weight; D002648:Child; D002784:Cholesterol / Q000097:blood; D004038:Diet, Reducing; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D009765:Obesity / Q000097:blood* / Q000178:diet therapy; D010974:Platelet Aggregation; D010978:Platelet Factor 4 / Q000032:analysis; D014280:Triglycerides / Q000097:blood
D008074:Lipoproteins; D014280:Triglycerides; D010978:Platelet Factor 4; D002784:Cholesterol
Der Effekt einer Gewichtsreduktion auf die Plättchenfunktion und die Serumlipoproteine bei übergewichtigen Kindern.