[Effects of antiarrhythmic agents on ventricular arrhythmias following myocardial infarct induced with glass beads in dogs (author's transl)].
Ventricular arrhythmias due to myocardial infarct were produced in 14 dogs, and the antiarrhytmic effects of quinidine (Qd), lidocaine (Lid), aprindine (Apr), and dl-propranolol (dl-Prop) were investigated. While recording the blood pressure and lead II ECG, a coronary cannula was inserted into a coronary orifice via the left carotid artery and a glass bead (diameter, 1.5 mm) was flushed into the left coronary artery. Beads were found at the descending branches in 12 and circumflex branches in 2 out of 14 gods, at autopsy. Using a telemetry system to record the lead II ECG of conscious, non-restricted dogs, the antiarrhythmic effects of Qd, Lid, Apr, and dl-Prop on ventricular arrhythmias 24 hours after coronary occlusion were compared. Apr and dl-Prop were about three times more potent than Qd and Lid. Although the durations of the antiarrhythmic effects of Apr, Lid, and dl-Prop were 20 to 30 min, that of Qd lasted longer. Since stable ventricular arrhythmias can be obtained by surgical intervention and the antiarrhythmic effects of standard compounds with glass beads can be used to study antiarrhythmic effects.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001073:Aprindine / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology; D003331:Coronary Vessels; D004195:Disease Models, Animal; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D005898:Glass; D007269:Injections, Intra-Arterial / Q000379:methods; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D009203:Myocardial Infarction / Q000150:complications* / Q000209:etiology; D011433:Propranolol / Q000627:therapeutic use; D011802:Quinidine / Q000627:therapeutic use
D000889:Anti-Arrhythmia Agents; D001073:Aprindine; D008012:Lidocaine; D011433:Propranolol; D011802:Quinidine