Endocrine profile of topterone, a topical antiandrogen, in three species of laboratory animals.
Topterone, 17 alpha-propyltestosterone, was administered parenterally or topically to rats, rabbits or hamsters to determine its endocrine profile. Systemic administration demonstrated that topterone was both antiandrogenic and progestational. Topical application failed to elicit a systemic antiandrogenic response at 1 g/kg/day and only a minimal progestational response was seen at 32 mg/kg/day. No other endocrine activities were detected.
D000287:Administration, Topical; D000726:Androgen Antagonists; D000818:Animals; D002369:Castration; D006224:Cricetinae; D005260:Female; D006728:Hormones / Q000378:metabolism; D007279:Injections, Subcutaneous; D008297:Male; D008647:Mesocricetus; D045167:Progesterone Congeners; D011817:Rabbits; D051381:Rats; D012737:Sex Factors; D013045:Species Specificity; D013739:Testosterone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D000726:Androgen Antagonists; D006728:Hormones; D045167:Progesterone Congeners; D013739:Testosterone; C022964:topterone