Levels of enolase and other enzymes in the cerebrospinal fluid as indices of pathological change.
The activities of enolase, aldolase, pyruvate kinase, lactate dehydrogenase and creatine phosphokinase were measured in cerebrospinal fluid of 121 patients presenting with a range of disorders of the central nervous system. The results from 41 patients undergoing myelography were used as controls. An assessment was made of the relative merits of these five enzymes as markers of brain damage with special reference to brain tumours. Enolase was the most sensitive marker of pathological change and was the only enzyme raised in the CSF of patients with low grade astrocytomas.
D000236:Adenoma / Q000201:enzymology; D001927:Brain Diseases / Q000201:enzymology*; D001932:Brain Neoplasms / Q000201:enzymology / Q000556:secondary; D003402:Creatine Kinase / Q000134:cerebrospinal fluid; D004798:Enzymes / Q000134:cerebrospinal fluid*; D005634:Fructose-Bisphosphate Aldolase / Q000134:cerebrospinal fluid; D006801:Humans; D006849:Hydrocephalus / Q000201:enzymology; D007770:L-Lactate Dehydrogenase / Q000134:cerebrospinal fluid; D008581:Meningitis / Q000201:enzymology; D009103:Multiple Sclerosis / Q000201:enzymology; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid*; D010911:Pituitary Neoplasms / Q000201:enzymology; D011770:Pyruvate Kinase / Q000134:cerebrospinal fluid
D004798:Enzymes; D007770:L-Lactate Dehydrogenase; D011770:Pyruvate Kinase; D003402:Creatine Kinase; D005634:Fructose-Bisphosphate Aldolase; D010751:Phosphopyruvate Hydratase