Anesthetics and electroconvulsive therapy seizure duration: implications for therapy from a rat model.
The anesthetic agents methohexital (Brevital), Innovar, and ketamine (Ketaject) were examined for their effect on seizure duration following electroconvulsive stimulation in a rat model of electroconvulsive therapy (ECT). Compared to unanesthetized control animals, methohexital anesthesia shortened seizure duration by 42%, ketamine anesthesia tended to increase seizure duration, and Innovar anesthesia had no effect on duration of seizures.
D000768:Anesthesia, General; D000818:Animals; D004329:Droperidol; D004338:Drug Combinations; D004565:Electroconvulsive Therapy / Q000379:methods*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D005283:Fentanyl; D007649:Ketamine; D008297:Male; D008723:Methohexital; D009115:Muridae
D004338:Drug Combinations; D007649:Ketamine; C001451:Innovar; D008723:Methohexital; D004329:Droperidol; D005283:Fentanyl