The influence of dithiosemicarbazone on the immunity of sheep to heartwater.
Four out of 9 sheep, immune to heartwater and subsequently treated with gloxazone, showed a febrile reaction when they were challenged 6 months later, but the same number of untreated controls also developed this reaction. In a second group of treated immune animals challenged after 9 months, 8 out of 8 showed a febrile reaction, whereas only 3 out of 8 controls reacted. Furthermore, the blood of one of the 4 sheep that reacted to challenge at 6 months was infective to a susceptible sheep inoculated with it, whereas that of 4 out of the 8 challenged at 9 months was infective.
D000818:Animals; D005260:Female; D006357:Heartwater Disease / Q000276:immunology*; D007111:Immunity, Cellular / Q000187:drug effects; D012756:Sheep / Q000276:immunology*; D012757:Sheep Diseases / Q000276:immunology*; D013882:Thiosemicarbazones / Q000494:pharmacology*; D013997:Time Factors
D013882:Thiosemicarbazones; C015848:dithiosemicarbazone