Metabolic detoxication of bis-(2-hydroxy-3, 5-dichlorophenyl)-sulfoxide in man.
The metabolic detoxication of bis(2-hydroxy-3, 5-dichlorophenyl)sulfoxide (BTS) in man was investigated. Bis(2-hydroxy-3, 5-dichlorophenyl)sulfide (BT) was identified in beta-glucuronidase treated urine following the administration of BTS by thin-layer chromatography, gas chromatography, ultraviolet spectrum and quantitative analysis. No other metabolites were detectable. BT-glucuronide was also identified in urine. It was assumed that BTS was reduced to BT and successively conjugated with glucuronide in man, and excreted as BT-glucuronide in the urine.
D000980:Antiplatyhelmintic Agents / Q000378:metabolism*; D001735:Bithionol / Q000031:analogs & derivatives / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D005965:Glucuronates / Q000378:metabolism; D006801:Humans; D008658:Inactivation, Metabolic; D008297:Male; D010084:Oxidation-Reduction; D010636:Phenols / Q000378:metabolism*
D000980:Antiplatyhelmintic Agents; D005965:Glucuronates; D010636:Phenols; C000297:bithionol sulfoxide; D001735:Bithionol