[Morphological investigations of the rat thyroid under lead intoxication and experimental hypothyroid (author's transl)].
Male white Wistar-rats are treated alone and in combination with methylthiouracil and lead acetate. The histologic-cytological and the caryometrical results and the weights of the thyroids show an increase thyroid activity following as well methylthiouracil as lead application. The thyroxin-iodine blood level and the cholesterol blood level are altered. The strongest enhancement of the activity is obtained in the combination group methylthiouracil plus lead acetate. More slow activations are present in the groups with singular application methylthiouracil or lead acetate application. The findings are caused by encymatic inhibition of the applicated substances.
D000818:Animals; D002467:Cell Nucleus / Q000473:pathology; D007037:Hypothyroidism / Q000139:chemically induced / Q000150:complications / Q000473:pathology*; D007620:Karyometry; D007854:Lead; D007855:Lead Poisoning / Q000150:complications / Q000473:pathology*; D008297:Male; D008779:Methylthiouracil; D009942:Organometallic Compounds; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000473:pathology*
D009942:Organometallic Compounds; D007854:Lead; D008779:Methylthiouracil; C008261:lead acetate
Morphologische Untersuchungen an der Rattenschilddrüse nach Bleiintoxikation und epxerimenteller Hypothreose.