Effect of cyclophosphamide on the thymus in mice.
A histologic and morphometric evaluation of weight of the thymus and content of Fc and C3 lymphocytes after a single dose of 300 mg cyclophosphamide per kg body weight in mice of the Swiss strain revealed a drop in the weight of the thymus and morphologic changes, manifested by elimination of lymphocytes from the cortical part of the thymus, followed by return to normal of the weight of the thymus and at the same time a rise in percentages of Fc and C3 receptor lymphocytes.
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology*; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011951:Receptors, Complement / Q000032:analysis; D011961:Receptors, Fc / Q000032:analysis; D012397:Rosette Formation; D013950:Thymus Gland / Q000033:anatomy & histology / Q000166:cytology / Q000187:drug effects*
D011951:Receptors, Complement; D011961:Receptors, Fc; D003520:Cyclophosphamide