title: [Analysis of histochemical changes caused by acute Wofatox poisoning in a model experiment].
abstract: Effect of Wofatox on the central nervous system, striated muscles and on the myocardium of rats has been studied by the aid of light- and electron microscopic histochemistry. A single intraperitoneal injection of LD50 of Wofatox resulted in a total inhibition of the activity of histochemically demonstrable acetyl-cholinesterase in the central nervous system. Each striated muscle fiber has shown different sensitivity to the inhibitor, but enzyme activity of end motor plates could not be totally inhibited. In lethal acute intoxication ultrastructural changes of the myocardiuim have shown characteristic features of cardiomyopathy.
mesh_terms: D000208:Acute Disease; D000818:Animals; D006321:Heart / Q000187:drug effects*; D006651:Histocytochemistry; D007928:Lethal Dose 50; D008743:Methyl Parathion / Q000506:poisoning*; D008854:Microscopy, Electron; D009132:Muscles / Q000187:drug effects* / Q000648:ultrastructure; D009206:Myocardium / Q000648:ultrastructure; D010278:Parathion / Q000031:analogs & derivatives*; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D008743:Methyl Parathion; D010278:Parathion
vernacular_title: Akut Wofatox mérgezés során bekövetkezö hisztokémiai változások elemzése modellkísérletben.