Direct effect of histamine on the production of adrenocortical hormone by guinea-pig adrenal cells.
In trypsin-dispersed adrenal cells of the guinea-pig, the production of 11-hydroxycorticosteroids in vitro was found to be significantly stimulated by 10(-7) -10(-4)M histamine and the maximum steroidogenic response (1.7-fold increase in 11-hydroxycorticosteroid production) was observed at 10(-6)M. The stimulatory action of histamine on steroidogenesis was blocked by cycloheximide treatment.
D015062:11-Hydroxycorticosteroids / Q000096:biosynthesis; D000305:Adrenal Cortex Hormones / Q000096:biosynthesis*; D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D008297:Male
D015062:11-Hydroxycorticosteroids; D000305:Adrenal Cortex Hormones; D006632:Histamine