[Effect of central cholinergic structures on the activity of the cardiovascular system].
Chronic experiments in dogs using acetylcholine and metamizil revealed participation of central cholinoreactive structures, the premotor cortex and head of the caudate nucleus in particular, in regulation of arterial pressure (AP), heart rate (HR) and respiration rate (RR). Acetylcholine first reduced the AP but the latter increased anew within 24 hrs. Metamizil increased the AP but, being applied to the caudate nucleus head, decreased it. Application of metamizil to the premotor cortical area as well as its i. m. administration (0.1 mg/kg) increased both the HR and RR. No effect of cholinergic structures of the parietal and temporal cortical areas upon the AP and HR was observed.
D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D001794:Blood Pressure; D001931:Brain Mapping; D002319:Cardiovascular System / Q000294:innervation*; D002421:Caudate Nucleus / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D004285:Dogs; D005625:Frontal Lobe / Q000502:physiology; D006339:Heart Rate; D010296:Parietal Lobe / Q000502:physiology; D013702:Temporal Lobe / Q000502:physiology
D000109:Acetylcholine
Vliianie tsentral' nykh kholinergicheskikh struktur na deiatel'nost' serdechno-sosudistoĭ sistemy.