Quantitative importance of non-skeletal-muscle N tau-methylhistidine and creatine in human urine.
The excretion of N tau-methylhistidine and creatinine was determined in a totally paralysed patient wih neither macroscopic nor microscopic detectable skeletal-muscle tissue. In this subject, it was possible for the first time to measure the basal non-skeletal-muscle-dependent excretion of N tau-methylhistidine and creatinine per 24 h and per kg of non-muscular body weight, 1.15 mumol (N tau-methylhistidine) and 35 mumol (creatinine) respectively. For the calculation of myofibrillar protein breakdown and skeletal-muscle mass on the basis of N tau-methylhistidine and creatinine excretion, the values have to be corrected for non-muscular sources. Our data show that skeletal-muscle tissue is the major contributor of N tau-methylhistidine in urine, since it contributes as much as 75% to the urinary excretion.
D003401:Creatine / Q000378:metabolism; D003404:Creatinine / Q000097:blood / Q000652:urine*; D005998:Glycine / Q000031:analogs & derivatives / Q000378:metabolism; D006639:Histidine / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008762:Methylhistidines / Q000652:urine*; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism* / Q000473:pathology; D009135:Muscular Diseases / Q000378:metabolism* / Q000473:pathology
D008762:Methylhistidines; C028120:1-methylhistidine; D006639:Histidine; D003404:Creatinine; C004946:glycocyamine; D003401:Creatine; D005998:Glycine