title: Uterine progesterone levels and intrauterine pressure in ovariectomized post partum rats.
abstract: Porter and Challis reported that the intrauterine pressure (IUP) of ovariectomized post partum rats was not suppressed by progesterone (P) treatment which increased uterine P levels. This experiment was repeated under rigorously controlled conditions. The exogenously induced increase in uterine P levels from 36 +/- 3 ng/g to 135 +/- 9 ng/g (p less than 0.001) reduced IUP from 61 +/- 3 mm Hg (p less than 0.001). When after 96 hours the P levels returned to pretreatment value, IUP also recovered from suppression.
mesh_terms: D000818:Animals; D002369:Castration; D004305:Dose-Response Relationship, Drug; D005260:Female; D049590:Postpartum Period; D011247:Pregnancy; D011312:Pressure; D011374:Progesterone / Q000032:analysis* / Q000097:blood / Q000494:pharmacology; D051381:Rats; D013997:Time Factors; D014599:Uterus / Q000032:analysis* / Q000502:physiology
chemical_list: D011374:Progesterone