[Plasma-antidiuretic hormone level as indicator of postoperative stress (part II) (author's transl)].
For a period of five days serum levels of antidiuretic hormone (ADH) have been investigated postoperatively in a group of 20 patients with upper abdominal surgery. In addition serum electrolytes (Na+, K+) and plasma osmolality have been controlled regularly. Patients in group A (n = 10) received Fentanyl epidurally (0.1-0.2 mg diluted with 0.9% saline solution) for treatment of postoperative pain, whereas in group B (n = 10) systemic opiate therapy was performed by intramuscular application of piritramide (Dipidolor, 15-25 mg). There was a significant increase in ADH in all patients, whereas serum electrolytes (Na+, K+) and plasma osmolality stayed within normal range. ADH-levels in group A (epidural opiate), however, were significantly lower than mean values in group B (systemic opiate application). The postoperative increase in ADH is interpreted as a reaction to stress and trauma, being less pronounced, when epidural opiate therapy is performed for postoperative pain treatment.
D000328:Adult; D000368:Aged; D000767:Anesthesia, Epidural; D004573:Electrolytes / Q000097:blood; D005260:Female; D005283:Fentanyl / Q000627:therapeutic use; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000097:blood / Q000188:drug therapy*; D010892:Pirinitramide / Q000627:therapeutic use; D013312:Stress, Physiological / Q000097:blood*; D013514:Surgical Procedures, Operative; D014667:Vasopressins / Q000097:blood*
D004573:Electrolytes; D014667:Vasopressins; D010892:Pirinitramide; D005283:Fentanyl
Plasma-ADH-Spiegel als perioperativer Stressparameter. 2. Mitteilung.