Arterial morphometry in neonatal and infant spontaneously hypertensive rats.
Media/lumen area ratios and density of arteries and arterioles were obtained from tail sections of newborn and 2-week-old spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY) on prenatal/postnatal high salt diets or standard salt diets. Fixation was by a solution which caused minimal contraction and no differences in contractile response between SHR and WKY. Standard salt SHR of both ages demonstrated significantly greater media/lumen ratios in intermediate size arterioles but not in smaller or larger arterial categories. Prenatal high salt caused significant medial thickening in 49- to 58- micrometer arterioles of newborn SHR. Maintenance on high salt to 2 weeks caused significant medial thickening i SHR arterioles of 19-38 micrometer outside diameter. High salt significantly increased the density of terminal arterioles in 2-week SHR.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001158:Arteries / Q000187:drug effects / Q000473:pathology; D001160:Arterioles / Q000187:drug effects / Q000473:pathology; D005260:Female; D006973:Hypertension / Q000473:pathology* / Q000503:physiopathology; D009119:Muscle Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology; D013623:Tail / Q000098:blood supply*
D012965:Sodium Chloride; D009638:Norepinephrine