Evidence for a carrier-mediated exchange-diffusion entry of calcium into erythrocytes.
The enthalpy of activation of entry of 45Ca into erythrocytes under conditions of zero net transport (19 Kcal/mol), inhibition of entry by N-ethylmaleimide, and transport pH optimum of 7 - 7.5 are consistent with a protein carrier for inward calcium movement. Initial rate analysis shows saturation kinetics and transstimulation, consistent with a carrier-mediated exchange-diffusion mechanism.
D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000097:blood*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005033:Ethylmaleimide / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics
D005033:Ethylmaleimide; D002118:Calcium