Interaction of glipizide and indoprofen.
The possible kinetic and dynamic interactions of indoprofen and glipizide were investigated in 6 healthy volunteers, taking indoprofen 200 mg t.i.d. for 7 days and a single dose of glipizide 5 mg before and during indoprofen medication. Series of blood samples were obtained for measurements of indoprofen, glipizide and glucose concentrations in blood. In addition urine concentrations of indoprofen were determined. The concentrations of indoprofen and glipizide were examined by HPLC and that of glucose enzymatically. Results suggest that indoprofen may reduce glipizide concentrations in plasma, but this does not seem to influence the blood glucose response to glipizide.
D000284:Administration, Oral; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D005260:Female; D005913:Glipizide / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D007216:Indoprofen / Q000378:metabolism* / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D010666:Phenylpropionates / Q000378:metabolism*; D013453:Sulfonylurea Compounds / Q000378:metabolism*
D001786:Blood Glucose; D010666:Phenylpropionates; D013453:Sulfonylurea Compounds; D007216:Indoprofen; D005913:Glipizide