Mouse skin beta-irradiated 3 months earlier shows increased content of a 30-50,000 MW mitotic inhibitor and decreased susceptibility to an exogenous inhibitor.
A 30,000-50,000 MW extract of mouse skin beta-irradiated 3 months previously with 3,000 rads, exerted a stronger in vivo inhibitory effect on mitoses in the basal layer of normal skin than a similar extract from unirradiated skin. Furthermore, epidermis beta-irradiated 3 months previously showed a reduced mitotic rate and a decreased susceptibility to inhibition by the 30-50,000 MW extract. The pathogenesis of the long term effect of irradiation might include interference with the functioning of a local mitotic inhibitor.
D000818:Animals; D004583:Electrons; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D008938:Mitosis / Q000187:drug effects*; D008970:Molecular Weight; D012867:Skin / Q000032:analysis* / Q000166:cytology / Q000528:radiation effects; D014020:Tissue Extracts / Q000302:isolation & purification* / Q000494:pharmacology
D014020:Tissue Extracts