Gastrointestinal sorbents for the treatment of uremia. I. Lightly cross-linked carboxyvinyl polymers.
Studies to determine the feasibility of using lightly cross-linked carboxyvinyl polymers as gastrointestinal sorbents in the treatment of uremia were conducted in normal and uremic rats. In normal rats, a highly swellable bead-form resin (150-2190) was found to decrease urinary N excretion and to increase fecal excretion of NH3, urea, total N, Na, K, Ca and Mg when fed at a level of 5 g/100g diet. There was also an increase in fecal water content and a marked decrease in fecal phosphate excretion. In rats made uremic by treatment with uranyl nitrate, 150-2190 decreased the rate of increase in BUN.
D000042:Absorption; D000180:Acrylic Resins; D000818:Animals; D001806:Blood Urea Nitrogen; D001834:Body Water / Q000378:metabolism; D004064:Digestive System / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D005260:Female; D008297:Male; D009355:Neomycin / Q000494:pharmacology; D009584:Nitrogen / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D011145:Polyvinyls / Q000627:therapeutic use; D011188:Potassium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012117:Resins, Synthetic / Q000627:therapeutic use*; D013213:Starch / Q000031:analogs & derivatives / Q000627:therapeutic use; D014511:Uremia / Q000188:drug therapy*
D000180:Acrylic Resins; D010710:Phosphates; D011145:Polyvinyls; D012117:Resins, Synthetic; C006912:carboxypolymethylene; D013213:Starch; C012880:dialdehyde starch; D009355:Neomycin; D009584:Nitrogen; D011188:Potassium