Unresponsiveness of human gastrointestinal smooth muscle to SRS-A.
Isolated longitudinal smooth muscle preparations from human gastrointestinal tissue were examined for contractile responsiveness to SRS-A (slow-reacting substance of anaphylaxis), histamine and acetylcholine. Although these tissues responded well to histamine and acetylcholine, they generally failed to respond to concentrations of SRS-A which elicit marked contractions of human airway tissue. There is, therefore, no evidence of a role for SRS-A in the control of gastrointestinal motility in man.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004064:Digestive System / Q000187:drug effects; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects*; D013189:SRS-A / Q000494:pharmacology*
D013189:SRS-A; D006632:Histamine; D000109:Acetylcholine