[Effects of tabernanthine on various cardiovascular parameters in the rat and dog (author's transl)].
1. Tabernanthine produced, in anaesthetized Rat and Dog, bradycardia and hypotension which remained after atropine or vagotomy. Bradycardia was significant from 0,5-0,8 mg . kg-1. The degree of hypotension depended upon the anaesthetic. 2. Effects of tabernanthine on cardiovascular parameters in anaesthetized Dog (blood pressure, heart rate, cardiac output, left ventricular pressure, dp/dt, cardiac potency, cardiac work and ventricular ejection volume) are described. There were no changes of noradrenaline, acetylcholine, tyramine or 5-hydroxytryptamine-induced cardiovascular effects by tabernanthine. 3. Bradycardia occurred also after per os tabernanthine administration in unanaesthetized Dog. 4. Tabernanthine reduced Rat isolated and perfused heart frequency. 5. It is suggested that tabernanthine has a direct action on myocardial muscle, probably by modification of calcium exchanges.
D000470:Alkaloids / Q000494:pharmacology*; D000771:Anesthesia, Intravenous; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002320:Cardiovascular Physiological Phenomena; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007050:Ibogaine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013318:Stroke Volume / Q000187:drug effects; D014628:Vagotomy
D000470:Alkaloids; D007050:Ibogaine; C027202:tabernanthine
Action de la tabernanthine sur différents paramètres cardiovasculaires chez le rat et chez le chien.