Cytogenetic in vivo and in vitro effects of low dose radiation and contrast agents.
Chromosome analysis was performed on five persons before and after urographic examination. Despite a small increase in chromosome aberration frequency after the examination, no statistically significant increase was demonstrated. Whole body lymphocytes were analyzed for chromosome aberrations after exposure to low dose radiation, contrast agents and radiation together with a contrast medium. A significant increase in aberration frequencies at the 2.5% level was observed in irradiated blood samples containing the iodized contrast agent metrizoate.
D000328:Adult; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007463:Iodobenzoates / Q000009:adverse effects*; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D008794:Metrizoic Acid / Q000009:adverse effects* / Q000494:pharmacology; D008875:Middle Aged; D014567:Urography
D007463:Iodobenzoates; D008794:Metrizoic Acid