The effect of a synthetic met-enkephalin analogue (FK 33-824) on gastric acid secretion and serum gastrin in man.
A synthetic met-enkephalin analogue was infused into seven healthy human subjects on a background infusion of pentagastrin to study the effect on gastric acid secretion and serum gastrin concentration. Gastric acid secretion rose from 4.2 meq H+/15 min to 7.8 meq H+/15 min during infusion of met-enkephalin, 0.1 micrograms/h. Met-enkephalin in a dose of 1 microgram/kg/h had no effect on pentagastrin-stimulated acid secretion. Serum gastrin concentration remained unchanged throughout the study. It is suggested that met-enkephalin could be a partial agonist on the  parietal cell. The possible role of met-enkephalin in the cephalic phase of gastric acid secretion is discussed.
D000328:Adult; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004723:Endorphins / Q000494:pharmacology*; D004745:Enkephalins / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood*; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D010418:Pentagastrin / Q000494:pharmacology; D013268:Stimulation, Chemical
D004723:Endorphins; D004745:Enkephalins; D005755:Gastrins; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; D010418:Pentagastrin