[Isolation and structure of the main metabolite of macrolide antibiotic turimycin H (author's transl)].
Turimycin H0 was isolated from the bile of rats as main metabolite after i.v. administration of turimycin H. It was also obtained by incubation of turimycin H with liver homogenates of dogs and rats. Degradation of turimycin H by liver homogenate of pigs was found to be relatively slow. Turimycin H0 was identified as 4"-deacylturimycin H by MS.
D000107:Acetylation; D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D066298:In Vitro Techniques; D007700:Kinetics; D007933:Leucomycins / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D051381:Rats; D013552:Swine
D007933:Leucomycins; C011138:turimycin
Isolierung und Struktur des Hauptmetaboliten des Makrolid-Antibioticums Turimycin H.