Investigation of the tumorigenic response to benzo(a)pyrene in aqueous caffeine solution applied orally to Sprague-Dawley rats.
In a lifetime experiment benzo(a)pyrene (B(a)P) was administered to Sprague-Dawley rats either as an admixture to the diet or by gavage in an aqueous 1.5% caffeine solution. Dissolved benzo(a)pyrene induced more tumors of the forestomach than undissolved benzo(a)pyrene. The 1.5% caffeine solution (annual dose 27 g/kg) did not exert any carcinogenic activity under the conditions of this bioassay.
D000284:Administration, Oral; D000818:Animals; D001580:Benzopyrenes / Q000008:administration & dosage* / Q000633:toxicity; D002110:Caffeine / Q000008:administration & dosage*; D004357:Drug Synergism; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D012995:Solubility; D012996:Solutions
D001580:Benzopyrenes; D012996:Solutions; D002110:Caffeine