Effect of growth hormone and oxandrolone singly and together on growth rate in girls with X chromosome abnormalities.
The linear growth effects of oxandrolone, human growth hormone, and Ox + hGH were compared in six girls, age 11 to 15 years, with X chromosome abnormalities (three with X,O karyotype, three with Turner syndrome variants). Over six successive three-month periods, the patient received either no treatment, Ox, hGH, or Ox + hGH. The data demonstrate a significant (P less than 0.001) synergistic effect between Ox and hGH in stimulating linear growth in Turner syndrome and its variants.
D000293:Adolescent; D000365:Age Determination by Skeleton; D001827:Body Height / Q000187:drug effects; D002648:Child; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006128:Growth / Q000187:drug effects; D006130:Growth Disorders / Q000188:drug therapy*; D013006:Growth Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D010074:Oxandrolone / Q000494:pharmacology / Q000627:therapeutic use*; D012729:Sex Chromosome Aberrations / Q000188:drug therapy; D014424:Turner Syndrome / Q000188:drug therapy*
D010074:Oxandrolone; D013006:Growth Hormone