title: Sexual dimorphism of SDS peptide patterns from the submaxillary glands of mice.
abstract: In mice (Mus musculus) sexual dimorphism is evident in the structure and function of the submaxillary glands, convoluted tubules being much more prominent in males than in females. Several enzymes are more abundant in the male gland. We have examined the submaxillary glands of male and female mice for the amounts of arginine peptidase and have made electrophoretic scans of SDS peptides in extracts of male and female glands during postnatal development and after androgen treatment. Larger peptides are relatively more abundant in female extracts, and smaller peptides are more abundant in the male extracts. The peptide patterns reflect the amount of arginine peptidase present in the extracts. No arginine peptidase could be detected in submaxillary salivary glands of mice from birth until 3 weeks of age. Then enzyme activity gradually increased, apparently induced by androgen hormones. The amounts of SDS peptides of high molecular weight steadily decreased with increasing age of the mouse and with increasing titers of arginine peptidase. Castration of the male led to the appearance of female SDS patterns; male patterns reappeared after treatment with testosterone. Females could be induced to form male patterns of SDS peptides by treatment with androgen hormones.
mesh_terms: D000367:Age Factors; D000728:Androgens / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D002369:Castration; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D008297:Male; D051379:Mice; D008970:Molecular Weight; D010455:Peptides / Q000378:metabolism*; D012737:Sex Factors; D013363:Submandibular Gland / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*
chemical_list: D000728:Androgens; D010455:Peptides