Comparison of cytotoxic action of iphosphamide and cyclophosphamide.
We compared the cytotoxic effects of cyclophosphamide and iphosphamide on normal hematopoietic colony-forming units (NCFU) and L1210 leukemia colony-forming units (LCFU), using the quantitative spleen colony assay. Cyclophosphamide was more cytotoxic for NCFU than iphosphamide, but both agents had a similar cytotoxic effect on LCFU survival, whether given as a single injection or a 24-hour infusion. Although both agents were less cytotoxic for LCFU when administered in 24-hour infusions, host toxicity indicated that correspondingly larger doses of each agent could be given by infusion. The two agents also exhibited very similar cell-killing kinetics.
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D003114:Colony-Forming Units Assay; D003520:Cyclophosphamide / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D007069:Ifosfamide / Q000494:pharmacology*; D007700:Kinetics; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA
D003520:Cyclophosphamide; D007069:Ifosfamide