Antitumor effect of dicyclohexylammonium sulfate, a potent inhibitor of spermidine, synthase.
The antitumor effect of dicyclohexylammonium sulfate (DCHA), a potent inhibitor of spermidine synthase, was tested on mice inoculated with Ehrlich ascites carcinoma, Ehrlich solid carcinoma and solid sarcoma-180. DCHA prolonged the survival time of mice bearing Ehrlich ascites carcinoma at doses of 50 approximately 100 mg/kg/day X 5. For Ehrlich solid carcinoma and solid sarcoma-180 the tumor growth was suppressed significantly at doses of 2 approximately 50 mg/kg/day X 10. The spermidine concentration of the tumor cells was lowered, while the spermine concentration hardly changed. The depletion of spermidine in the tumor cells might be a cause of the suppression of tumor growth.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000378:metabolism; D003514:Cyclohexylamines; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use*; D012510:Sarcoma 180 / Q000188:drug therapy / Q000378:metabolism; D013095:Spermidine / Q000378:metabolism; D011436:Spermidine Synthase / Q000037:antagonists & inhibitors*; D013096:Spermine / Q000378:metabolism; D014166:Transferases / Q000037:antagonists & inhibitors*
D000970:Antineoplastic Agents; D003514:Cyclohexylamines; D004791:Enzyme Inhibitors; D000644:Quaternary Ammonium Compounds; C011769:dicyclohexylamine; D013096:Spermine; D014166:Transferases; D011436:Spermidine Synthase; D013095:Spermidine