title: Mitochondrial-membrane polar-head-group composition is influenced by diet fat.
abstract: Male Sprague-Dawley rats were fed diets containing 20% (w/w) soya-bean oil, high-erucic acid rapeseed oil or low-erucic acid rapeseed oil for 0, 12 or 23 days. The type of fat present in the diet had no effect on the total phospholipid content of heart mitochondria (micrograms/mg of protein) but did influence the phospholipid class distribution. Rats fed high-erucic acid rapeseed oil for 12 or 23 days had significantly higher mitochondrial phosphatidylcholine content than rats fed soya-bean oil. Low-erucic acid rapeseed oil resulted in elevation of cardiac mitochondrial cardiolipin content after dietary treatment for 12 days. The results demonstrate in vivo that diet is a significant determinant of the phospholipid class content of subcellular membranes.
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D004041:Dietary Fats / Q000494:pharmacology*; D004883:Erucic Acids / Q000494:pharmacology; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004041:Dietary Fats; D004883:Erucic Acids; D008565:Membrane Proteins; D010743:Phospholipids; D002784:Cholesterol