Studies of a fibrinolytic enzyme from the larvae of Lonomia achelous (Cramer) using chromogenic peptide substrates.
A fibrinolytic agent purified from the haemolymph, hair secretion and whole body extract of Lonomia achelous (Cramer) cleaves various chromogenic peptide substrates. The best substrate were found to be pyro-Glu-Gly-Arg-pNA (S-2444) followed by D-Pro-Phe-Arg-pNA (S-2302) and Bz-Ile-Glu-(or) Gly-Arg-pNA (S-2222) designed for urokinase, plasma kallikrein and factor Xa, respectively. Using substrate S-2251 we also found a plasminogen activator.
D000818:Animals; D002863:Chromogenic Compounds / Q000378:metabolism; D005343:Fibrinolytic Agents / Q000302:isolation & purification; D006458:Hemolymph / Q000201:enzymology; D007814:Larva / Q000201:enzymology; D010455:Peptides / Q000378:metabolism
D002863:Chromogenic Compounds; D005343:Fibrinolytic Agents; D010455:Peptides