Comparison of oral and inhaled metaproterenol for prevention of exercise-induced asthma.
The effectiveness of inhaled versus oral metaproterenol in preventing exercise-induced asthma (EIA) was studied. Inhaled metaproterenol given 10 min before the exercise significantly reduced the degree of EIA in a group of twenty-four patients, and in 75% of them completely prevented it. The mean percentage decrease in FEV1 was 6.5% with the inhaler and 30.1% with placebo. When inhaled 1 hr before the exercise, metaproterenol was still better than placebo but its effectiveness was considerably lower. Metaproterenol tablets had a slight protective effect given 1 hr before, and none when administered 2 hr before exercise. There was no correlation between the protective effect against EIA and the bronchodilating effect obtained before exercise. Metaproterenol administered by metered-dose inhaler is a very effective prophylactic medication against clinically troublesome EIA, while metaproterenol tablets should not be recommended for this purpose.
D000281:Administration, Intranasal; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D001250:Asthma, Exercise-Induced / Q000188:drug therapy*; D001980:Bronchi / Q000187:drug effects; D005080:Exercise Test; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D009921:Metaproterenol / Q000008:administration & dosage* / Q000627:therapeutic use; D010919:Placebos; D013607:Tablets
D010919:Placebos; D013607:Tablets; D009921:Metaproterenol