Preventive effects of L-ascorbic acid and calcium pantothenate against photosensitive actions induced by pheophorbide alpha and hematoporphyrin.
The preventive effects of L-ascorbic acid (V.C) and pantothenic acid (PaA) against photosensitized hemolysis in the presence of pheophorbide a or hematoporphyrin were investigated in vitro. The development of hematoporphyrin-induced photosensitivity and the preventive effects of V.C and PaA were also investigated in male mice. V.C and PaA exerted preventive effects against photosensitized hemolysis in the presence of pheophorbide a or hematoporphyrin. In such cases, V.C and PaA had not only an additive effect but also a synergistic one. The time required for the photosensitized acute shock-like death (i.e., survival time), was significantly extended by simultaneous administration of V.C and PaA. This supports the findings of in vitro experiments.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000633:toxicity; D004357:Drug Synergism; D006415:Hematoporphyrins / Q000633:toxicity*; D006461:Hemolysis / Q000187:drug effects / Q000528:radiation effects; D008027:Light; D008297:Male; D051379:Mice; D010205:Pantothenic Acid / Q000494:pharmacology*; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000517:prevention & control; D051381:Rats
D006415:Hematoporphyrins; D002734:Chlorophyll; D010205:Pantothenic Acid; C032623:pheophorbide a; D001205:Ascorbic Acid