Conversion of spironolactone to an active metabolite in target tissues: formation of 7 alpha-thiospironolactone by microsomal preparations from guinea pig liver, adrenals, kidneys, and testes.
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006168:Guinea Pigs; D007668:Kidney / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D013058:Mass Spectrometry; D008861:Microsomes / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism*; D009928:Organ Specificity; D013053:Spectrophotometry; D013148:Spironolactone / Q000031:analogs & derivatives* / Q000378:metabolism*; D013737:Testis / Q000378:metabolism*
D013148:Spironolactone; C033554:7 alpha-thiospironolactone; D003577:Cytochrome P-450 Enzyme System