title: Prolactin suppression and spermatogenic developments in maturing rats. A quantitative study.
abstract: Prolonged suppression of prolactin (PRL) in immature male rats inhibits the spermatocyte-spermatid conversion process, alters leydig cell morphology, decreases accessory sex organ weight and increases serum LH levels without a significant alteration in serum FSH concentration. Amelioration of these effects by exogenous PRL strongly indicates that in the absence of PRL excess titers of endogenous LH fail to exert an influence on the spermatogenic activity of maturing testes.
mesh_terms: D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D007985:Leydig Cells / Q000648:ultrastructure; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011388:Prolactin / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D012671:Seminiferous Tubules / Q000033:anatomy & histology; D013076:Sperm Count; D013087:Spermatids / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects / Q000254:growth & development*
chemical_list: D001971:Bromocriptine; D011388:Prolactin; D007986:Luteinizing Hormone