title: Pregnancy diagnosis in Macaca fascicularis. Hemagglutination inhibition test for urinary chorionic gonadotropin and implantation bleeding.
abstract: The Subhuman Primate Pregnancy Tube Test (SHPT test) was useful for early pregnancy diagnosis in cynomolgus monkeys (Macaca fascicularis). Test results were correct in 86.5% of series of four successive urine samples. SHPT test results were not confirmed in 13.5% of series, comprising two (false) negative series in pregnant animals and 13 (false) positive series in nonpregnant animals. In ten of 13 false-positive series, a positive-negative sequence was observed in successive test results, presumably due to a decline in chorionic gonadotropin levels. In all animals with a false-positive SHPT test, early embryonic mortality was most probable, since all showed normal cycling activity immediately afterwards. Postmating bleeding records were not reliable for pregnancy diagnosis. A practical approach for the use of the SHPT test in the individual breeding of monkeys is given.
mesh_terms: D000818:Animals; D006063:Chorionic Gonadotropin / Q000652:urine; D010064:Embryo Implantation; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006385:Hemagglutination Inhibition Tests / Q000662:veterinary; D008251:Macaca / Q000502:physiology*; D008252:Macaca fascicularis / Q000502:physiology*; D008598:Menstruation; D011247:Pregnancy; D011259:Pregnancy Tests, Immunologic / Q000662:veterinary*
chemical_list: D006063:Chorionic Gonadotropin