Modeling of dose-response relationships.
The main dose-response models for chronic toxicity are considered. For dichotomous response, the log probit, multi-hit, and multistage models are presented. For time-to-occurrence response, the log-normal and three variations of multistage models are presented. Finally, the Cornfield hockey-stick model is considered, and, for low-dose extrapolation, it is suggested that response be taken to be proportional to dose and to a power of time determined by background response.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D008962:Models, Theoretical; D013223:Statistics as Topic; D013997:Time Factors; D014116:Toxicology