Age-related variations in human lymphocyte DNA.
The molecular weight of DNA from human peripheral lymphocytes has been measured on alkaline sucrose density gradients. The number average molecular weight (MN) of DNA is found to decrease as the age of the donor increases. This result is discussed with reference to lesions in DNA, both repairable and non-repairable, which may accumulate with age.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D002499:Centrifugation, Density Gradient; D004247:DNA / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight
D004247:DNA