title: Improvement of bleeding time, platelet aggregation and platelet count during CAPD treatment.
abstract: Mean bleeding time in 11 uraemic patients improved from 11.2 (range 3.5--20) before the 5.8 (range 2.5--20) minutes during CAPD treatment (p less than 0.025). Bleeding time became normal in six out of seven patients with a prolonged bleeding time prior to CAPD. There was a concomitant improvement in platelet aggregation. Mean platelet count rose from 195 (range 117--414) to 311 (148--522) x 10(9)/L (p less than 0.01). A significant correlation was found between the change in bleeding time and in platelet aggregation induced by ristocetin, but not between the change in bleeding time and the platelet count. Our results suggest that CAPD treatment improves the uraemic bleeding tendency, even in patients on previous haemodialysis treatment.
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001760:Bleeding Time; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010974:Platelet Aggregation / Q000187:drug effects*; D010976:Platelet Count; D010979:Platelet Function Tests; D012310:Ristocetin / Q000494:pharmacology; D014511:Uremia / Q000097:blood* / Q000628:therapy
chemical_list: D012310:Ristocetin; D000244:Adenosine Diphosphate; D003094:Collagen; D004837:Epinephrine