title: Intravascular neutrophilic granulocyte kinetics in horses.
abstract: Intravascular granulocyte kinetics in 4 healthy horses were determined with chromium-51 as the cell label. The disappearance rate of labeled granulocytes was an exponential function. Mean total blood granulocyte pool (+/- 1 SD) was 5.65 +/- 1.514 X 10(8) granulocytes/kg of body weight, of which 2.71 +/- 0.715 X 10(8) granulocytes/kg were circulating and 2.94 +/- 0.876 X 10(8) granulocytes/kg were marginated along blood vessel walls. The mean disappearance half-life (T1/2) was 10.5 +/- 1.33 hours and the mean granulocyte turnover rate was 8.84 +/- 1.495 X 10(8) granulocytes/kg/day. A granulokinetic trial performed on a horse recovering from a recent infection revealed increases in all granulokinetic measurements.
mesh_terms: D000818:Animals; D002469:Cell Separation / Q000662:veterinary; D006098:Granulocytes / Q000378:metabolism*; D006207:Half-Life; D006736:Horses / Q000097:blood* / Q000378:metabolism; D007531:Isoflurophate; D007700:Kinetics
chemical_list: D007531:Isoflurophate