Pregnancy diagnosis in Macaca fascicularis. Hemagglutination inhibition test for urinary chorionic gonadotropin and implantation bleeding.
The Subhuman Primate Pregnancy Tube Test (SHPT test) was useful for early pregnancy diagnosis in cynomolgus monkeys (Macaca fascicularis). Test results were correct in 86.5% of series of four successive urine samples. SHPT test results were not confirmed in 13.5% of series, comprising two (false) negative series in pregnant animals and 13 (false) positive series in nonpregnant animals. In ten of 13 false-positive series, a positive-negative sequence was observed in successive test results, presumably due to a decline in chorionic gonadotropin levels. In all animals with a false-positive SHPT test, early embryonic mortality was most probable, since all showed normal cycling activity immediately afterwards. Postmating bleeding records were not reliable for pregnancy diagnosis. A practical approach for the use of the SHPT test in the individual breeding of monkeys is given.
D000818:Animals; D006063:Chorionic Gonadotropin / Q000652:urine; D010064:Embryo Implantation; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006385:Hemagglutination Inhibition Tests / Q000662:veterinary; D008251:Macaca / Q000502:physiology*; D008252:Macaca fascicularis / Q000502:physiology*; D008598:Menstruation; D011247:Pregnancy; D011259:Pregnancy Tests, Immunologic / Q000662:veterinary*
D006063:Chorionic Gonadotropin