Acid citrate dextrose reduces platelet retention during in vitro and in vivo dog hemoperfusion: a comparative study of different charcoal adsorbers.
Hemoperfusion through charcoal adsorbers has often been proposed for use in exogenous and endogenous intoxication. A serious drawback of this technique is the often encountered loss of platelets and leucocytes. In vitro hemoperfusion studies with heparinized human blood and in vivo hemoperfusion of heparinized Labrador dogs through different types of charcoal adsorbers (Becton-Dickinson [B-D], Gambro, Haemocol) clearly demonstrated that addition of the anticoagulant acid citrate dextrose (ACD) might reduce the loss of platelets. ACD seemed to have no distinct influence on leucocyte retention.
D000327:Adsorption; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D002448:Cell Adhesion / Q000187:drug effects; D002606:Charcoal; D002951:Citrates / Q000097:blood; D019343:Citric Acid; D004285:Dogs; D005947:Glucose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D006464:Hemoperfusion; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count
D002951:Citrates; C002113:acid citrate dextrose; D002606:Charcoal; D019343:Citric Acid; D005947:Glucose