title: Alterations in electrophysiology of cultured BALB/cfC3H mouse mammary epithelium associated with neoplastic transformation.
abstract: Mammary tumor virus and neoplastic transformation affect prolactin-modulated electrophysiology of mouse mammary epithelium in vitro. Transepithelial resistances of both prelactating and neoplastic BALB/cfC3H mouse mammary epithelial cell cultures are lower than those seen in BALB/c prelactating cell cultures. Unlike the response to prolactin in BALB/c cultures, there are no effects of this hormone on transepithelial potential difference or resistance of BALB/cfC3H prelactating or neoplastic cultures. However, prolactin significantly increases short-circuit current in both BALB/c and BALB/cfC3H prelactating cell cultures and in BALB/cfC3H neoplastic cell cultures. The response of tumor cell cultures suggests that pregnancy-independent mouse mammary epithelium may not be entirely refractory to prolactin.
mesh_terms: D000818:Animals; D002463:Cell Membrane Permeability; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D004848:Epithelium / Q000378:metabolism; D005260:Female; D007774:Lactation; D008321:Mammary Glands, Animal / Q000378:metabolism*; D008564:Membrane Potentials; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D011388:Prolactin / Q000494:pharmacology; D014412:Tumor Virus Infections
chemical_list: D011388:Prolactin