[Lysolecithin and lecithin. Influence in the etiopathogenesis of chronic and acute gastritis as related to bile reflux and duodenal juice. Experimental study].
The authors studied three groups of rats with had their stomachs exposed to lecithin, lisolecithin and salt solution action. They noticed through histopathologic methods and DNA dosages of the studied stomachs that lisolecithin can promote gastric inflammatory lesions as well the research method chosen has promoted acute erosive gastritis in various animals. They have also noticed, with gastric DNA dosages, a higher cell desquamation with the lisolecithin group. The authors have considered this method efficient to demonstrate precocious gastric lesions. The authors arise the question if lisolecithin present in duodenal juices (formed by the action of A phospholipase of the pancreatic juice with bilious lecithin) and the biliary salts constitute a substance of great importance to the gastric lesions produced by the alkaline reflux to the stomach.
D000818:Animals; D001655:Bile Reflux / Q000150:complications; D004386:Duodenum; D005753:Gastric Mucosa / Q000187:drug effects*; D005756:Gastritis / Q000139:chemically induced / Q000209:etiology*; D007419:Intestinal Secretions / Q000032:analysis; D008244:Lysophosphatidylcholines / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000494:pharmacology*; D051381:Rats; D013270:Stomach / Q000473:pathology
D008244:Lysophosphatidylcholines; D010713:Phosphatidylcholines
Lisolecitina e lecitina. Influencia na etiopatogenia das gastrites crónicas e agudas, relacionadas ao refluxo de bile e suco duodenal. Estudo experimental.