title: The topically irritant substance: essentials - bio-tests - predictions.
abstract: The paper describes a method for judging the irritative potentialities of substances; proposes a scoring system with which the 'ordinary' risks of many of the abundant marketed products for washing, cleaning etc. may be predicted without biological testing; discusses pharmacodynamic and pharmacokinetic aspects of topical irritancy and points to the problems of extrapolating from animal experiments to man.
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007509:Irritants / Q000145:classification / Q000633:toxicity*; D051379:Mice; D012997:Solvents
chemical_list: D007509:Irritants; D012997:Solvents