Gaba-antagonists alter spatial summation in receptive field centres of rod- but not cone-drive cat retinal ganglion Y-cells.
1. When Y-type cat retinal ganglion cells were driven by cones, the i.v. administration of the GABA-antagonist picrotoxin failed to alter receptive field centre size. 2. This result is in marked contrast to our previous finding that when Y-cells were driven by rods, GABA-antagonists led to specific and reversible changes in centre size. 3. These results taken together suggest that for centre signals of Y-cells, the rod and cone pathways are pharmacologically distinct.
D000818:Animals; D002415:Cats; D003623:Dark Adaptation; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010786:Photoreceptor Cells / Q000502:physiology*; D010852:Picrotoxin / Q000494:pharmacology*; D012160:Retina / Q000166:cytology* / Q000187:drug effects; D014794:Visual Fields / Q000187:drug effects
D010852:Picrotoxin