Effects of methyl mercury on protein synthesis in vitro.
Methyl mercury has been shown to interact with protein synthesis in vivo and in vitro. In the present paper a brain postmitochondrial supernatant was used for studies in vitro. Inorganic mercury (Hg2+) was shown to be more potent inhibitor of protein synthesis than methyl mercury, puromycin or cycloheximide. The inhibitory effect of methyl mercury was potentiated by puromycin. It is thus possible that methyl mercury causes disintegration of polysomes in brain cells.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003513:Cycloheximide / Q000494:pharmacology; D004357:Drug Synergism; D007930:Leucine; D008297:Male; D008628:Mercury / Q000494:pharmacology; D008767:Methylmercury Compounds / Q000494:pharmacology*; D008928:Mitochondria / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D011691:Puromycin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D008767:Methylmercury Compounds; D009419:Nerve Tissue Proteins; D011691:Puromycin; D003513:Cycloheximide; D008628:Mercury; D007930:Leucine