Renal function after prolonged hypotensive anesthesia and surgery in dogs with reduced renal mass.
The effect of prolonged hypotensive anesthesia and surgery on renal function was studied in 8 dogs with decreased renal mass. Renal mass was reduced by unilateral nephrectomy and ligation of 4 of the 6 terminal renal artery branches of the opposite kidney. One week after reduction in renal mass, the dogs were azotemic with a serum urea nitrogen (SUN) value of 65.8 +/- 11.5 mg/dl. Glomerular filtration rate, as estimated by 14C-inulin clearance, was 0.66 +/- 0.19 ml/kg of body weight/hour. A mean arterial pressure of less than 75 mm of Hg was maintained for 4 hours in dogs given 2.3 +/- 0.7% halothane. An exploratory laparotomy lasting 1 hour was performed. The day after the hypotensive episode, 3 dogs began vomiting, became dehydrated, and had SUN values greater than 100 mg/dl. The SUN values returned to base-line values after the dogs were rehydrated. Eight days after the hypotensive episode, 14C-inulin clearance decreased 15.2 +/- 8.2% (P less than 0.005) compared with base-line clearance values. Light microscopic and electron microscopic observations of the kidneys did not demonstrate acute renal failure. Prolonged hypotensive anesthesia can cause a decrease in renal function, and may cause prerenal uremia and/or acute renal failure.
D000769:Anesthesia, Inhalation / Q000662:veterinary*; D000818:Animals; D003401:Creatine / Q000097:blood; D004283:Dog Diseases / Q000503:physiopathology; D004285:Dogs / Q000502:physiology / Q000601:surgery*; D005919:Glomerular Filtration Rate; D006221:Halothane; D007022:Hypotension / Q000503:physiopathology / Q000662:veterinary; D007668:Kidney / Q000502:physiology*; D007813:Laparotomy / Q000662:veterinary; D008026:Ligation / Q000662:veterinary; D008297:Male; D009392:Nephrectomy / Q000662:veterinary; D009994:Osmolar Concentration; D012077:Renal Artery / Q000601:surgery; D013046:Specific Gravity; D014556:Urine
D003401:Creatine; D006221:Halothane