title: Search for possible CNS depressant compounds: Part II. Synthesis of some new 1-(2'-methoxy-4'-nitrophenyl)-2-phenyl-4-substituted arylidene-5-imidazolones as CNS depressants.
abstract: Some new 1-(2'-methoxy-4'-nitrophenyl)-2-phenyl-4-substituted benzylidene, furylidene and naphthylidene-5-imidazolones have been synthesized and tested on their CNS. anticonvulsant and analgesic activities in albino mice. At a dose of 200 mg/kg they displayed CNS depressant properties producing ataxia, decrease in spontaneous motor activity and loss of righting reflex. They also exhibited mild anticonvulsant activity in the pentetrazol test.
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D001522:Behavior, Animal / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D051379:Mice; D012018:Reflex / Q000187:drug effects
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D002492:Central Nervous System Depressants; D007093:Imidazoles