[Adaptation of the peripheral organs of rats to noradrenaline deficiency following chronic desympathization].
In 3--week guanetidine--desympathized rats, the noradrenaline (NA) concentration in myocardium, small intestine and ductus deferens constituted 1, 6 and 3% of the control, resp., whereas release of the NA from the ductus deferens on transmural stimulation dropped to 3%. From 4 to 16--week age the NA content in myocardium and small intestine reached 30 and 23%, resp., and its release was equal to control. The diminishing of NA content was followed by augmented adrenaline--sensitivity and diminished cholinosensitivity of the organs under study. Significance of local adaptive mechanisms for normalizing of activity of the adrenergic nervous system under conditions of desympathization, is considered.
D000109:Acetylcholine / Q000494:pharmacology*; D000311:Adrenal Glands / Q000294:innervation; D000320:Adrenergic Fibers / Q000502:physiology*; D000367:Age Factors; D000818:Animals; D006145:Guanethidine; D006321:Heart / Q000294:innervation; D007421:Intestine, Small / Q000294:innervation; D008297:Male; D009638:Norepinephrine / Q000032:analysis / Q000172:deficiency*; D051381:Rats; D013563:Sympathectomy, Chemical; D014649:Vas Deferens / Q000294:innervation
D000109:Acetylcholine; D009638:Norepinephrine; D006145:Guanethidine
Adaptatsiia perifericheskikh organov krys k nedostatku noradrenalina pri khronicheskoĭ desimpatizatsii.