Genetic studies on the in vitro PHA-transformation of porcine blood lymphocytes.
The response of pig peripheral blood lymphocytes to phytohaemagglutinin (PHA) was studied by a whole blood technique. The material for study comprised 441 offspring from one generation of a randomly mated Danish Landrace pig herd. The pigs were blood-sampled at a weight of 90 kg. After correlation for influence from other blood cells and for seasonal variation, the heritability of the PHA stimulation responses at different PHA concentrations were estimated. The heritability estimates ranged from 0.15 to 0.53. Also the PHA concentration giving maximum stimulation response, as calculated by a dose response function, was found to vary depending on genetic variation among the pigs with an estimated heritability of 0.38.
D000818:Animals; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D014644:Genetic Variation; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000276:immunology; D008934:Mitogens; D010835:Phytohemagglutinins / Q000494:pharmacology; D013552:Swine / Q000235:genetics* / Q000276:immunology
D008934:Mitogens; D010835:Phytohemagglutinins