title: Sister-chromatid exchanges induced by some chromium compounds in human lymphocytes in vitro.
abstract: Treatments with various concentrations of K2Cr2O7, CaCrO4 and CrO3 were given to human lymphocytes cultured in presence of BrdUrd for 2 replicative cycles. Sister-chromatid exchanges (SCEs) were visualized by a combination of fluorescent and Giemsa techniques. In all cases, the higher the concentrations the higher the frequencies of SCEs per metaphase and per chromosome. On a concentration basis, the order of effectiveness in producing SCEs was: CaCrO4 much greater than CrO3 greater than K2Cr2O7.
mesh_terms: D001973:Bromodeoxyuridine / Q000494:pharmacology; D017610:Calcium Compounds; D002478:Cells, Cultured; D002840:Chromates / Q000494:pharmacology*; D002857:Chromium / Q000494:pharmacology*; D017608:Chromium Compounds; D003434:Crossing Over, Genetic / Q000187:drug effects*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology*; D011192:Potassium Dichromate / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D017610:Calcium Compounds; D002840:Chromates; D017608:Chromium Compounds; D002857:Chromium; C028801:chromium trioxide; D001973:Bromodeoxyuridine; C033750:calcium chromate(VI); D011192:Potassium Dichromate