The influence of long-term application of isoproterenol on the results of temporary ischemia of the rat heart muscle.
The results presented demonstrate that long-term application of small doses of isoproterenol produces an adaptive reaction in the heart muscle with increase of its tolerance of oxygen deficiency induced by temporary ischemia. After adapting animals in the described manner muscle necrosis appears delayed and to a smaller extent. Our results also emphasize the view that the definitive myocardial damage is determined by the secondary disturbances of microcirculation. Furthermore, our findings support the idea of a pharmacologically induced adaptation of the heart muscle resulting in an increased tolerance of ischemic injury.
D000222:Adaptation, Physiological; D000818:Animals; D003327:Coronary Disease / Q000473:pathology*; D005260:Female; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology*; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D010101:Oxygen Consumption; D051381:Rats; D011919:Rats, Inbred Strains
D007545:Isoproterenol