[Possibilities and limitations of eye-preserving procedures in malignant melanoma of the uvea (author's transl)].
From 1964 to 1980, 255 patients suffering from choroidal melanoma underwent a primary eye-preserving procedure. Of these, 205 were irradiated with 106Ru/106Rh beta-ray applicators (dose: 80-100 Gy at the summit of the tumor within 14 days). In 132 cases (64.4%) this treatment was successfully within a follow-up period of 5.4 years: 60 patients (45.5%) developed a flat scar, 34 (25.8%) retained a visual acuity of 1.5 to 0.5. Thirty-six eyes had to be enucleated after radiotherapy. Thirty-seven patients died, 21 of them from metastases. The survival rate, 85.1% after five years and 71.9% after ten years, is significantly higher than that of patients whose eyes were enucleated as a primary procedure. Fifty patients suffering from melanoma of the anterior uveal tract were treated with the following surgical procedures: iridocyclectomy in 42 cases, iridectomy in three cases and choroidectomy also in three cases. Twenty patients retained a visual acuity of 1.5 to 0.8 during the average follow-up period of 7.5 years. In 11 patients the eye had to be enucleated later. Four patients died from metastases. The survival rate of this group with local tumor excision was 96% during the follow-up period.
D000328:Adult; D005500:Follow-Up Studies; D006801:Humans; D008545:Melanoma / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D008875:Middle Aged; D011829:Radiation Dosage; D011859:Radiography; D014604:Uveal Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery / Q000628:therapy*
Möglichkeiten und Grenzen bulbuserhaltender Massnahmen beim malignen Melanom der Uvea.