REM sleep suppression in cats by melatonin.
The pineal indole melatonin, injected into the third ventricle of unanesthetized cats, induced NREM sleep within 11-15 min and suppressed REM sleep for about 3 hr. A dose-related effect could be established between 1, 10 and 100 ng melatonin. The reappearance of REM sleep at about 3 hr following melatonin administration occurred with a marked rebound. The present results further support the hypothesis that melatonin represents the releasing hormone for pineal arginine vasotocin.
D000818:Animals; D002415:Cats; D003864:Depression, Chemical; D006801:Humans; D008550:Melatonin / Q000494:pharmacology*; D012895:Sleep, REM / Q000187:drug effects*; D013045:Species Specificity; D014668:Vasotocin / Q000494:pharmacology
D008550:Melatonin; D014668:Vasotocin