Heterogeneous in vitro sensitivities of metastatic B16 melanoma sublines and clones to retinoic acid or BCNU.
Murine B16 melanoma sublines have been cloned or selected in vivo for preference of bloodborne metastatic colonization of lung, ovary, or brain. These sublines show differing metastatic properties and cell surface alterations that correlate with a preference for metastatic colonization sites. When the sensitivities of these selected sublines to certain drugs (beta-all-trans retinoic acid or 1,3-bis (2-chlorethyl)-1-nitrosourea (BCNU) were examined, the in vivo-selected sublines were more resistant to growth inhibition in vitro by cytostatic (retinoic acid) or cytotoxic (BCNU) drugs than was the parental B16 line.
D000818:Animals; D002330:Carmustine / Q000627:therapeutic use*; D002460:Cell Line; D002999:Clone Cells; D004353:Drug Evaluation, Preclinical; D008545:Melanoma / Q000188:drug therapy*; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D014212:Tretinoin / Q000627:therapeutic use*
D014212:Tretinoin; D002330:Carmustine