Bioavailability of phenobarbital by rectal administration.
Phenobarbital was administered to five patients, eight to 20 years of age, by four different administration routes: Intravenous, intramuscular, oral, and rectal. At each administration, extent of bioavailability, elimination rate constant, absorption rate constant, and volume of distribution of phenobarbital were calculated using a one-compartment open model. The results obtained suggest that rectal administration of phenobarbital is more reliable than intramuscular or oral administration of the drug for rapid treatment in children.
D000293:Adolescent; D000328:Adult; D001682:Biological Availability; D002648:Child; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics; D010634:Phenobarbital / Q000008:administration & dosage* / Q000378:metabolism; D012007:Rectum; D013488:Suppositories; D013997:Time Factors
D013488:Suppositories; D010634:Phenobarbital