Haemodynamic and neurological responses of ventilated and apnoeic calves to succinyldicholine.
Succinyldicholine-induced asphyxia in awake calves led to massive catecholamine release by the adrenal medulla. Hypertension and bradyarrhythmias resulted. Electroencephalograms recorded during periods of succinyldicholine-induced apnoea indicated that calves were probably conscious and under psychic stress for at least 4 min after the onset of apnoea. Electroencephalographic signs indicative of decreased consciousness became evident in one calf only after 4,8 min of apnoea but were absent in 3 calves subjected to maximum periods of apnoea of 4,1; 3,2 and 4,4 min. The latter 3 calves all recovered with no apparent neurological deficit after intravenous injection of plasma pseudocholinesterase.
D000818:Animals; D001049:Apnea / Q000139:chemically induced / Q000662:veterinary*; D002395:Catecholamines / Q000097:blood; D002417:Cattle / Q000502:physiology*; D002418:Cattle Diseases / Q000139:chemically induced; D004569:Electroencephalography; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D010146:Pain / Q000662:veterinary; D010243:Paralysis / Q000139:chemically induced / Q000662:veterinary*; D013390:Succinylcholine / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D002395:Catecholamines; D013390:Succinylcholine