Ibuprofen-induced gastrointestinal changes.
Effect of Ibuprofen on food requirements and body weight was studied in experimental animals. A considerable fall of rat body weight was observed, proportional to the administered dose and duration of treatment. Ibuprofen had no influence no food requirement. It was also demonstrated that Ibuprofen caused disturbances in intestinal motor function which might lead to the development of malabsorption syndrome.
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake; D007052:Ibuprofen / Q000494:pharmacology* / Q000633:toxicity; D007421:Intestine, Small / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009929:Organ Size / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000187:drug effects / Q000473:pathology*
D007052:Ibuprofen