[Heart muscle mitochondria function in alpha-tocopherol deficient rabbits. (author's transl)].
In the mitochondria of alpha-tocopherol deficient rabbit hearts (30 days) there was a close correlation between the decline in respiration and the incidence of membrane peroxidation. The intraperitoneal injections of alpha-tocopherol (25 mg/kg) from the the 28th day to the 30th day to the vitamin E deficient rabbits prevented a decline in either the mitochondrial respiratory or in the lipid peroxidation breakdown. The addition of alpha-tocopherol "in vitro" to the alpha-tocopherol deficient cardiac mitochondria failed to improve their function. As a result of this study, the possibility that the alpha-tocopherol may protect the cardiac mitochondrial activity by preserving their integrity appears to be consolidated.
D000818:Animals; D008929:Mitochondria, Heart / Q000378:metabolism*; D010101:Oxygen Consumption; D011817:Rabbits; D051381:Rats; D014810:Vitamin E / Q000008:administration & dosage / Q000502:physiology; D014811:Vitamin E Deficiency / Q000188:drug therapy / Q000378:metabolism*
D014810:Vitamin E
Studio della funzionalità mitocondriale nel muscolo cardiaco di conigli alimentati in carenza di alpha-tocoferolo.