Mechanism of the protective effect of propylthiouracil against acetaminophen (Tylenol) toxicity in the rat.
D000082:Acetaminophen / Q000506:poisoning*; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control; D004195:Disease Models, Animal; D005978:Glutathione / Q000378:metabolism; D007037:Hypothyroidism / Q000139:chemically induced; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009336:Necrosis; D011441:Propylthiouracil / Q000494:pharmacology*; D051381:Rats; D013961:Thyroid Gland / Q000502:physiology; D013965:Thyroidectomy
D000082:Acetaminophen; D011441:Propylthiouracil; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione