title: The effect of polyvaccinum and vaccinum cholericum on the PCA test and degranulation of mast cells in sensitized mice.
abstract: The authors studied the effect of bacterial vaccines-Polyvaccinum and Vaccinum cholericum on the production of homocytotropic antibodies and degranulation of mastocytes in sensitized mice. It has been found that stimulation with high antigen doses causes degranulation of intraperitoneal mast cells and addition of polyvaccine results in its marked increase. A 2 h PCA test in mice sensitized with high antigen doses showed dynamic patterns similar in all groups of animals whereas high IgG 1 titres were obtained in animals sensitized with small antigen doses after administration of polyvaccine. Higher PCA titers persisting for 4 weeks were also noted in the 72 h test.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001428:Bacterial Vaccines / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D007111:Immunity, Cellular; D008297:Male; D008407:Mast Cells / Q000276:immunology*; D051379:Mice
chemical_list: D001428:Bacterial Vaccines