The pharmacokinetics of cefuroxime lysine in the elderly.
Single doses of 750 mg of cefuroxime lysine were given to eight elderly patients. The mean plasma half life was 124 minutes and the mean time to peak was 82 minutes. When compared with previous studies in young healthy volunteers, while peak plasma concentrations are similar, there is prolongation of half life and delay of excretion of the drug in the elderly. In our group studied, no local discomfort was noted following injection.
D000368:Aged; D002444:Cefuroxime / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000378:metabolism*; D002511:Cephalosporins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007700:Kinetics; D008297:Male; D013997:Time Factors
D002511:Cephalosporins; C027301:cefuroxime lysine; D002444:Cefuroxime