Carcinogenicity in Syrian golden hamsters of N-nitrosamines formed during nitrosation of spermidine.
Several N-nitrosamines are formed during the nitrosation of the polyamines, spermidine and spermine. Since these polyamines may represent a source for the endogenous or exogenous formation of N-nitrosamines, their major nitrosation products were assayed for carcinogenicity in male Syrian golden hamsters. Administration of N-nitroso-3-butenyl(2-propenyl)amine SC once a week for life at a dose of 300 mg/kg induced neoplasms mostly in the upper respiratory tract (nasal cavity, larynx, trachea). Lung microlithiasis (alveolar and bronchial) also developed in all these animals. In contrast, N-nitroso-3-butenyl(3-hydroxypropyl)amine and N-nitroso-4-hydroxybutyl(2-propenyl)amine induced neoplasms, primarily in the digestive tract, including the nonglandular stomach, cecum, colon, and adrenal gland.
D000818:Animals; D002085:Butylhydroxybutylnitrosamine / Q000633:toxicity; D002273:Carcinogens; D006224:Cricetinae; D008297:Male; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009602:Nitrosamines / Q000633:toxicity; D013095:Spermidine
D002273:Carcinogens; D009602:Nitrosamines; D002085:Butylhydroxybutylnitrosamine; C010426:gamma-butenyl-(beta-propenyl)nitrosamine; C037174:4-hydroxybutyl-(2-propenyl)nitrosamine; C037173:3-butenyl-(3-hydroxypropyl)nitrosamine; C037175:3-carboxypropyl-(2-propenyl)nitrosamine; D013095:Spermidine