title: The effect of oxandrolone on low and high density lipoprotein profiles in retired breeder rats.
abstract: The retired breeder rat, an animal known to undergo premature aging and to develop hypercholesterolemia, was studied to determine the effect of oxandrolone, a synthetic hypolipidemic steroid, on serum lipoprotein subfractions. The methods utilized for this study included density ultracentrifugation, electron microscopic lipoprotein particle sizing, and disc gel electrophoresis. The data confirmed the cholesterol-lowering ability of oxandrolone and demonstrated that its effect on total serum cholesterol was limited to the low and high density lipoprotein subclasses. The drug-treated group had 50% less LDL cholesterol and 25% less HDL cholesterol. Though there was an absolute decrease in total serum cholesterol in both these fractions, there was a re-distribution of cholesterol, such that post-treatment LDL carried less cholesterol and HDL more cholesterol on a percentage basis than found in pre-treatment values. In the light of current concepts of atherogenicity these alterations are of interest and potentially of considerable value.
mesh_terms: D000375:Aging; D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004591:Electrophoresis, Polyacrylamide Gel; D006937:Hypercholesterolemia / Q000188:drug therapy; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D010074:Oxandrolone / Q000494:pharmacology* / Q000627:therapeutic use; D010316:Particle Size; D051381:Rats
chemical_list: D000924:Anticholesteremic Agents; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D010074:Oxandrolone