Effect of heparin on vitamin A induced hyperlipidemia in rats.
Effect of intravenous administration of heparin (5 I.U.) has been studied on vitamin A induced changes in plasma, liver, kidney, heart and adipose tissue of rats. Heparin reversed vitamin A induced hypertriglyceridemia. It reduced plasma TG and PC levels and increased NEFA and LPC levels in control and retinol fed rats. Similar pattern was noted in the palmitate-1-14C radioactivity of these plasma lipids. Heparin administration did not influence the levels of lipids and phospholipids and their palmitate-1-14C radioactivity in liver and kidney of retinol fed rats. In heart heparin improved the uptake of plasma TG in retinol fed rats and increased its FFA levels. Similar pattern was observed in the palmitate-1-14C radioactivity of the above heart lipids. In adipose tissue heparin administration improved the uptake of plasma lipids of vitamin A fed rats.
D000818:Animals; D006493:Heparin / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000139:chemically induced / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014801:Vitamin A / Q000494:pharmacology*
D014801:Vitamin A; D006493:Heparin