[Age peculiarities of the intake dynamics of (35S)thiamine and its phosphoric esters administered parenterally into rat organs].
The maximal intake of [35S]thiamine for the first hours followed administration of its physiological dose (150 mumol/kg) into the blood small intestine, kidneys, liver, myocardium and brain grows in ontogenesis by 55-60, 25-30, 80-110, 25-40, 15-30, 5-12%. This evidences for a more pronounced thiamine lack in old animals as compared to the young ones. After injection of labelled thiamine diphosphate the increment of the vitamin B1 total amount is the highest in the kidneys and small intestine of old animals. A higher increment of the vitamin B1 total amount in tissues of old rats after the labelled thiamine injection may be explained by a delayed intensity of its renewal deficiency. [35S]thiamine phosphate and [35S]thiamine diphosphate especially enter all organs, except for the liver, more intensively than [35S]thiamine (their amount is by 25-40% higher in all age groups).
D000375:Aging; D000818:Animals; D001921:Brain / Q000378:metabolism*; D006321:Heart / Q000254:growth & development; D007421:Intestine, Small / Q000254:growth & development / Q000378:metabolism*; D007668:Kidney / Q000254:growth & development / Q000378:metabolism*; D008099:Liver / Q000254:growth & development / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009928:Organ Specificity; D051381:Rats; D013831:Thiamine / Q000378:metabolism*
D013831:Thiamine
Vozrastnye osobennosti dinamiki postupleniia v tkani krys parenteral'no vvedennykh [35S]tiamina i ego fosfornykh éfirov.