Cytotoxicity of L-canavanine in vitro.
Cytotoxicity of L-canavanive, a structural analogue of L-arginine, was tested by means of (1) inhibition of DNA synthesis in Balb/c-3T3 cell line and (2) inhibition of mitosis in peripheral blood lymphocytes in culture. The cytostatic nature of inhibition caused by L-canavanine was indicated by the complete recovery of cells after withdrawal of the drug.
D000818:Animals; D001120:Arginine / Q000494:pharmacology; D002172:Canavanine / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008938:Mitosis / Q000187:drug effects; D008940:Mitotic Index
D002172:Canavanine; D004247:DNA; D001120:Arginine