The influence of infusion rate on the acute intravenous toxicity of phytic acid, a calcium-binding agent.
The intravenous toxicity of phytic acid (inositol hexakisphosphate, IHP) has recently become of interest because of the potential for IHP incorporation into red blood cells to achieve a therapeutically useful shift in the hemoglobin-oxygen dissociation curve (Gersonde, K. and Nicolau, C., Blut, 39 (1979) 1). The observed acute intravenous toxicity of IHP in rodents is consistent with its recognized capacity to bind calcium. The toxic manifestations of intravenous IHP are a function of rate of infusion as well as total dose, with some seemingly anomalous variations which may related to compensatory mechanisms. The data suggest that significant alterations of plasma calcium and the toxic potential of such alterations are not likely to result from the administration of red blood cells with IHP incorporated.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D007263:Infusions, Parenteral; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010833:Phytic Acid / Q000008:administration & dosage* / Q000378:metabolism / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D010833:Phytic Acid; D002118:Calcium