[Urinary enzyme excretion after prophylactic antibiotic therapy in patients following colorectal surgery (author's transl)].
The urinary excretion of N-acetyl-beta-glucosaminade (NAG) and alanine aminopeptidase (AAP) was measured as an indicator for nephrotoxicity to neomycin and gentamycin in patients after colorectal surgery. We found that the continuous determination of urinary enzymes is a good indicator for the degree of kidney damage. The dose dependence of nephrotoxicity was influenced by the severity of colorectal surgery. The simple method of urinary enzyme determination seems to be a very valuable test to detect parenchymal damage of the kidney after prophylactic antibiotic therapy.
D000118:Acetylglucosaminidase / Q000652:urine*; D000410:Alanine Transaminase / Q000652:urine*; D003110:Colonic Neoplasms / Q000601:surgery*; D004359:Drug Therapy, Combination; D005839:Gentamicins / Q000009:adverse effects* / Q000627:therapeutic use; D006596:Hexosaminidases / Q000652:urine*; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008875:Middle Aged; D009355:Neomycin / Q000009:adverse effects* / Q000627:therapeutic use; D012004:Rectal Neoplasms / Q000601:surgery*; D013530:Surgical Wound Infection / Q000517:prevention & control
D005839:Gentamicins; D000410:Alanine Transaminase; D006596:Hexosaminidases; D000118:Acetylglucosaminidase; D009355:Neomycin
Harnenzymausscheidung nach präventiver antibiotikatherapie bei dickdarmresezierten patienten.