Negative results of carcinogenicity bioassay of methyl carbazate in rats: significance for the toxicological evaluation of carbadox.
Methyl carbazate, a metabolite of carbadox in the rat, was administered orally to rats for 2 years. The compound was mixed in the diet at concentrations corresponding to dose levels of 0, 2.5, 5 and 10 mg/kg body wt/day. There was no evidence of any treatment-related toxicity or, in particular, of carcinogenicity.
D000818:Animals; D001681:Biological Assay; D002218:Carbadox / Q000378:metabolism / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D006834:Hydrazines / Q000633:toxicity*; D008297:Male; D011810:Quinoxalines / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; D006834:Hydrazines; D011810:Quinoxalines; C033887:methyl carbazate; D002218:Carbadox