Evidence for the existence of a dopamine-sensitive adenylate cyclase in chick optic tectum.
The effects of several concentrations of dopamine on chick optic tectum adenylate cyclase were studied. Dopamine produced a dose-dependent increase in the intracellular content of c-AMP. These effects were specifically antagonized by haloperidol and chlorpromazine, whereas antagonists at alpha-and beta-adrenoceptors were significantly less effective. In conclusion, the present experiments provide evidence for the existence within the avian optic tectum of a dopamine-sensitive adenylate cyclase activity.
D000262:Adenylyl Cyclases / Q000032:analysis*; D000818:Animals; D002645:Chickens; D004298:Dopamine / Q000494:pharmacology*; D013477:Superior Colliculi / Q000201:enzymology*
D000262:Adenylyl Cyclases; D004298:Dopamine