Measurement of fibrinolytic activity after epsilon-aminocaproic acid administration in rats (Rattus norvegicus).
The antifibrinolytic agent, epsilon-aminocaproic acid was administered to rats via either intraperitoneal injection or intravenous infusion. Time-response and dose-response studies of the resultant plasma levels of fibrinolytic activity were measured by a modification of a standard fibrin plate technique. The modified technique involved the addition of human plasma to rat plasma in a ratio of 10:1 (rat:human). The plasma levels of fibrinolytic activity reflected plasma concentrations of epsilon-aminocaproic acid.
D000614:Aminocaproates / Q000494:pharmacology*; D015119:Aminocaproic Acid / Q000494:pharmacology*; D000818:Animals; D000933:Antifibrinolytic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005342:Fibrinolysis / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000614:Aminocaproates; D000933:Antifibrinolytic Agents; D015119:Aminocaproic Acid