title: An improved method to study antibacterial activity of antibiotics in an in vitro model simulating serum levels.
abstract: The bacterial activity of cefoxitin was studied in an improved in vitro model simulating serum levels. The peak concentration of cefoxitin was 110 mcg/ml as achieved after 1 g i.v. Half-life time was adjusted to 50 minutes. The time at which the viable count reached the mark 1% of the original inoculum after the lowest count was determined (regrowth period) ranged from one to 10 hours from the beginning of the experiments.
mesh_terms: D000900:Anti-Bacterial Agents / Q000097:blood / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002440:Cefoxitin / Q000494:pharmacology; D006801:Humans; D008954:Models, Biological; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D002440:Cefoxitin