A genetic factor controlling morphogenesis of the laryngotracheo-esophageal complex the mouse.
A new autosomal, recessive lethal mutation in the mouse cause failure of division of the embryonic foregut into totally separate digestive and respiratory ducts. The newborn homozygote has a cleft that extends between the laryngotracheal and esophageal tubes, allowing excessive air to pass into the stomach and subsequently into the peritoneal cavity. This mutation has been designated lec (laryngotracheo-esophageal cleft). The common region shared by the respiratory and digestive tubes has features characteristic of both structures. Development of cartilage around the laryngotracheo-esophageal complex is also affected in the mutant.
D000818:Animals; D004947:Esophagus / Q000002:abnormalities*; D005804:Genes, Lethal; D005808:Genes, Recessive; D007817:Laryngeal Cartilages / Q000002:abnormalities; D007830:Larynx / Q000002:abnormalities*; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics; D009154:Mutation; D010641:Phenotype; D014132:Trachea / Q000002:abnormalities*