[Assessment of potential blood substitute solutions with oxygen-carrying properties and their possible uses].
Beside the necessary volume effect (isoosmotic and isooncotic solution) and the physiological bicarbonate concentration (prevention of dilution acidosis) a possible blood substitute with O2 carrier characteristics should enable an optimal O2 transport: Viscosity as low as possible and shear rate independent (Newtonian behavior), O2 concentration at the given O2 partial pressure at least 6 ml/dl, and mean capillary O2 partial pressure as high as possible. For the judgement of such a blood substitute, the so-called O2 supply index is recommended, i.e., O2 concentration times mean capillary O2 partial pressure divided by viscosity.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D001692:Biological Transport / Q000187:drug effects; D001802:Blood Substitutes / Q000378:metabolism* / Q000627:therapeutic use; D001809:Blood Viscosity / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D006801:Humans; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000187:drug effects; D010313:Partial Pressure
D001802:Blood Substitutes; D010100:Oxygen
Zur Beteiligung potentieller Blut-Ersatzlösungen mit Sauerstoffträgereigenschaften den deren Einsatzmöglichkeiten.