Thymoma-specific antibodies in sera from patients with myasthenia gravis demonstrated by indirect haemagglutination.
An indirect haemagglutination technique for the demonstration of antibodies to skeletal muscle is described. Eight out of 9 sera from unoperated myasthenia gravis (MG) patients with thymoma and 6 out of 22 sera taken from MG patients who had been operated upon for a thymoma, contained antibodies to this antigen. Twenty-five sera from MG patients with histologically verified thymus hyperplasia did not contain such antibodies. There was no relationship between these antibodies and antibodies to acetylcholine receptor.
D001323:Autoantibodies / Q000032:analysis; D006386:Hemagglutination Tests; D006801:Humans; D009132:Muscles / Q000276:immunology; D009157:Myasthenia Gravis / Q000150:complications / Q000276:immunology*; D013945:Thymoma / Q000150:complications / Q000276:immunology*; D013953:Thymus Neoplasms / Q000150:complications / Q000276:immunology*
D001323:Autoantibodies