Individualization of oral theophylline dosage in elderly patients.
The present study is a prospective evaluation of a dosing nomogram for oral theophylline in 69 middle-aged and elderly patients (mean age 58.5 +/- 15.4 years) with obstructive lung disease. The main features of the nomogram were that the theophylline dose was increased in middle-aged as compared to old patients, and that smokers were always prescribed a higher dose than non-smokers of a similar age. The target theophylline concentration is presently defined as a trough level at steady state of 50 micromol/l. Approximately 50% of the patients achieved theophylline levels within +/- 20% of the target concentration, and none had theophylline levels exceeding 110 micromol/l. We conclude that the nomogram represents a useful guide in establishing a safe initial theophylline dose in this patient group.
D000284:Administration, Oral; D000367:Age Factors; D000368:Aged; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012907:Smoking; D013806:Theophylline / Q000008:administration & dosage*
D013806:Theophylline