Differential miscibility properties of various phosphatidylcholine/lysophosphatidylcholine mixtures.
Using enthalphy data from differential scanning calorimetry experiments and 13C-NMR linewidths of specifically (N-Me-13C)-labelled lipids, the miscibility properties of phosphatidylcholines and lysophosphatidylcholines in liposomal dispersons have been investigated. It was found that 16 : 0 lysophosphatidylcholine mixes homogeneously in 16 : 0/16 : 0 phosphatidylcholine bilayers. Mixtures of 16 : 0 lysophosphatidylcholine with 18 : 1c/18 : 1c phosphatidylcholine, of 18 : 1c lysophosphatidylcholine with 16 : 0/16 : 0 phosphatidylcholine and of 18 : 1c lysophosphatidylcholine with 18 : 1c/18 : 1c phosphatidylcholine of exhibited immiscibility in the phosphatidylcholine gel state.
D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002621:Chemistry; D008051:Lipid Bilayers; D008244:Lysophosphatidylcholines; D009682:Magnetic Resonance Spectroscopy; D010713:Phosphatidylcholines; D013696:Temperature
D008051:Lipid Bilayers; D008244:Lysophosphatidylcholines; D010713:Phosphatidylcholines