Effects of methyltestosterone on bile secretion in female and male rats.
No adverse effect on bile secretion was noted in methyltestosterone-treated female rats. In male rats, methyltestosterone administration exerted a cholestatic effect, which is not only due to the decrease of bile salt excretion rate, but also to a possible interference of the steroid with bile salt micelle size.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects; D008297:Male; D008777:Methyltestosterone / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D013997:Time Factors
D008777:Methyltestosterone