title: Arsenic exposure in a copper smelter as related to histological type of lung cancer.
abstract: Tissue samples from lung cancer patients who had worked at a copper smelter and from controls were collected and classified by a panel of pathologists: 38% of the cancers were found to be adenocarcinomas, compared to 12% among the controls, a statistically significant difference (p less than 0.05). The predominance of adenocarcinomas was associated with arsenic exposure. This finding is not consistent with Kreyberg's hypothesis that small-cell undifferentiated and epidermoid carcinomas are the only type that increase in response to inhaled carcinogens [1962].
mesh_terms: D000368:Aged; D001151:Arsenic / Q000009:adverse effects*; D003300:Copper; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008669:Metallurgy; D009784:Occupational Diseases / Q000139:chemically induced*
chemical_list: D003300:Copper; D001151:Arsenic