Influence of salbutamol and other beta-agonists on hypothermia induced by clonidine, apomorphine and reserpine in mice.
Clonidine administered to mice induced hypothermia and this effect was antagonized by a single dose of the following beta-agonists: salbutamol, isoprenaline and terbutaline. The effect of these beta-agonists was completely antagonized by propranolol. The effect of terbutaline on reserpine-and apomorphine-induced hypothermia was also studied; it causing a slight but significant reversal of hypothermia. This effect was also blocked by propranolol. The results obtained here showed these beta-agonists behave in a manner similar to other antidepressant drugs. The data reinforces the view that beta-stimulation is of great importance in antidepressant action.
D000420:Albuterol / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors; D003000:Clonidine / Q000037:antagonists & inhibitors*; D004347:Drug Interactions; D007035:Hypothermia / Q000139:chemically induced*; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011433:Propranolol / Q000494:pharmacology; D012110:Reserpine / Q000037:antagonists & inhibitors; D013726:Terbutaline / Q000494:pharmacology*
D012110:Reserpine; D011433:Propranolol; D007545:Isoproterenol; D003000:Clonidine; D001058:Apomorphine; D013726:Terbutaline; D000420:Albuterol