[Preliminary data on intestinal chemoreceptor responses to amino acids].
Intestinal chemoreceptor responses to amino acids in the small intestine were investigated in anaesthetized cats with a microelectrophysiological technique, i.e. vagal units in the nodose ganglion were recorded by extracellular glass microelectrodes. About 400 neurons were tested by infusing the small intestine with a mixture of several amino acids at 38 degrees C. Fifty neurons, which were generally silent before the first infusion, were activated by amino acid solutions with a short latency of a few seconds. Their discharge frequency was always low (less than 10 Hz). The corresponding fibres were non-medullated (conduction velocity: 0.8-1.4 m/s). These receptors did not respond to osmotic or mechanical stimuli. Moreover, some of them were not activated by glucose infusion and must thus be considered as specific amino acid receptors. The others which responded to both amino acids and glucose infusions were non-specific receptors. The properties of these two types of amino receptors and their roles in the nervous regulations of feeding behaviour, in particular protein satiety, are discussed.
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D002628:Chemoreceptor Cells / Q000187:drug effects / Q000502:physiology*; D004594:Electrophysiology; D007421:Intestine, Small / Q000502:physiology*; D008839:Microelectrodes; D009474:Neurons / Q000502:physiology; D010477:Perfusion
D000596:Amino Acids
Données préliminaires sur la réponse des chémorécepteurs intestinaux aux acides aminés.