Effects of intraventricular administration of sympathomimetic agents on metabolic, vasomotor and temperature responses in Taiwan monkeys.
Intraventricular administration of either norepinephrine, tyramine or angiotensin II produced dose-dependent hypothermia, decreased metabolism and lowered cutaneous temperatures in Taiwan monkeys at ambient temperatures of 4 and 22 degrees C. The hypothermia reflected the heat storage consequent to the net effects of decreased heat production and decreased heat loss. In heat (35 degrees C), these agents produced dose-dependent hyperthermia in monkeys. The hyperthermia was brought about mainly by a decrease in dry heat loss.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007035:Hypothermia / Q000139:chemically induced; D007276:Injections, Intraventricular; D008251:Macaca; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology*; D014439:Tyramine / Q000494:pharmacology; D014666:Vasomotor System / Q000187:drug effects
D013566:Sympathomimetics; D000804:Angiotensin II; D009638:Norepinephrine; D014439:Tyramine