[Mechanism of the therapeutic effect of exogenous superoxide dismutase: findings and prospects].
The hazards arising from oxygen radicals and the enzymatic function of superoxide dismutase (SOD) is discussed with regard to established and potential therapeutic effects of the injected enzyme. A monistic interpretation of the therapeutic effect of SOD in inflammatory diseases considers .02- production as a pathogenetic principle and the enzymatic elimination of the harmful radical by exogenous SOD as the counterbalancing mechanism. This hypothesis is elaborated upon taking into account the sites of endogenous .02- production, established .02-dependent types of tissue damage and availability of injected SOD. It is concluded that clinical conditions associated with .02- release from inflammatory cells will benefit from SOD injections, if relevant tissue levels are provided.
D002374:Catalase / Q000378:metabolism; D005609:Free Radicals; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism / Q000627:therapeutic use*
D005609:Free Radicals; D002374:Catalase; D013482:Superoxide Dismutase; D010100:Oxygen
Der therapeutische Wirkungsmechanismus von exogen zugeführter Superoxiddismutase: Befunde und Ausblicke.