title: Tolerance to rectal ketamine in paediatric anaesthesia.
abstract: The use of rectal ketamine as the sole anaesthetic for short, minor procedures in young children is discussed. A case in which 18 anaesthetics were administered by this route, to facilitate radiotherapy, is reported and the subsequent development of tolerance and its possible mechanisms are discussed.
mesh_terms: D000774:Anesthesia, Rectal; D002528:Cerebellar Neoplasms / Q000532:radiotherapy; D002675:Child, Preschool; D004361:Drug Tolerance; D006801:Humans; D007649:Ketamine / Q000008:administration & dosage; D008297:Male; D008527:Medulloblastoma / Q000532:radiotherapy; D010342:Patient Acceptance of Health Care; D013997:Time Factors
chemical_list: D007649:Ketamine