title: [Nicotinamide coenzyme content in the myocardium of growing rats undergoing pharmacological sympathectomy].
abstract: Content of nicotinamide coenzymes was studied in myocardium of 7-, 30-days old and 3-5-months old rats. Content of these coenzymes was increased during early ontogenesis. Single, intraperitoneal administration of sympatholytics reserpine (2.5 mg pe kg), ornide (5 mg per kg) and dopegite (300 mg per kg) led to alteration in the content of nicotinamide coenzymes in animals of all the age groups; these alterations depended apparently an age characteristics of neurohormonal regulation and of myocardium metabolism.
mesh_terms: D000375:Aging / Q000187:drug effects; D000818:Animals; D001950:Bretylium Tosylate / Q000494:pharmacology; D005260:Female; D006128:Growth / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D008297:Male; D008750:Methyldopa / Q000494:pharmacology; D009206:Myocardium / Q000201:enzymology*; D009243:NAD / Q000032:analysis*; D009249:NADP / Q000032:analysis*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D013563:Sympathectomy, Chemical; D013565:Sympatholytics / Q000494:pharmacology
chemical_list: D013565:Sympatholytics; D009243:NAD; D009249:NADP; D008750:Methyldopa; D001950:Bretylium Tosylate; D012110:Reserpine
vernacular_title: Soderzhanie nikotinamidnykh kofermentov v miokarde rastushchikh krys pri farmakologicheskoĭ desimpatizatsii.