Studies on visceral Leishmania tropica infection in BALB/c mice. I. Clinical features and cellular changes.
The visceral and lethal infection produced in BALB/c mice by Leishmania tropica (major) is accompanied by splenomegaly, anaemia and reversal of albumin-to-globulin ratio. The percentages of both B and T cells are decreased in the spleen. The spleen and lymph nodes become populated with large Ig-, Thy 1.2- 'null' cells. The similarity of some of these parameters with those produced in human kala-azar is discussed.
D000818:Animals; D005260:Female; D006801:Humans; D007898:Leishmaniasis, Visceral / Q000097:blood / Q000276:immunology / Q000473:pathology*; D008099:Liver / Q000473:pathology; D008215:Lymphocytes, Null; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000276:immunology / Q000473:pathology