Effects of ascorbic acid on neutrophil locomotion.
The effects of ascorbic acid on neutrophil locomotion were studied in experimental conditions able to dissociate random from truly directional motility. It was shown that the significant enhancement of chemotaxis achievable with high ascorbic acid concentrations was due to an increase of the true chemotactic response. With lower concentrations of ascorbic acid, chemotactic values were unaffected as the result of an increase in the rate of neutrophil locomotion with a concomitant inhibition of the true chemotactic response. Ascorbic acid appeared to exert its effect on the whole moving cell population.
D001205:Ascorbic Acid / Q000494:pharmacology*; D002465:Cell Movement / Q000187:drug effects*; D002630:Chemotactic Factors / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology
D002630:Chemotactic Factors; D001205:Ascorbic Acid