Effects of etiocholanolone and prednisolone on intravascular granulocyte kinetics in horses.
The functional capacity of the marrow granulocyte reserve (MGR) in 4 adult horses was studied, using 51Cr-labeled leukocytes. The mean increase in the peripheral granulocyte count following injections of etiocholanolone (0.3 mg/kg) was 870 granulocytes/mm3, and the mean increase following prednisolone administration (200 mg) was 5,880 granulocytes/mm3. Etiocholanolone failed to mobilize the MGR and decreased the rate of granulocyte egress from the blood. Prednisolone rapidly mobilized the MGR and markedly decreased the granulocyte specific activity during the first 3 hours after injection.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism; D005043:Etiocholanolone / Q000494:pharmacology*; D006098:Granulocytes / Q000187:drug effects* / Q000378:metabolism; D006736:Horses / Q000097:blood / Q000378:metabolism*; D007700:Kinetics; D007958:Leukocyte Count / Q000662:veterinary; D011239:Prednisolone / Q000494:pharmacology*
D005043:Etiocholanolone; D011239:Prednisolone