title: Recent concepts on the mechanism of action of methotrexate.
mesh_terms: D000818:Animals; D001692:Biological Transport; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects; D003201:Computers; D004247:DNA / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D005493:Folic Acid Antagonists; D007700:Kinetics; D008727:Methotrexate / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D051381:Rats; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism; D013763:Tetrahydrofolates / Q000096:biosynthesis*
chemical_list: D005493:Folic Acid Antagonists; D013763:Tetrahydrofolates; D004247:DNA; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate