Suppression of the humoral immune response to inactivated Newcastle disease virus by Mycoplasma meleagridis in the Turkey.
Groups of Mycoplasma meleagridis-free and -infected turkeys were vaccinated against Newcastle disease virus (NDV) at 5 and 8 weeks of age. The two groups did not differ significantly in antibody response to NDV as measured by the hemagglutination-inhibition test when a live vaccine (TCND) was used, but the two groups differed significantly when an inactivated vaccine was used; titers were higher in the mycoplasma-free group in both primary and secondary responses. The difference between responses of the mycoplasma-free and -infected groups to inactivated and live NDV was explained by a current hypothesis about the ontogeny of B-cell differentiation in the bursa of Fabricius and by its interference by M. meleagridis.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D002060:Bursa of Fabricius / Q000276:immunology / Q000382:microbiology; D006385:Hemagglutination Inhibition Tests / Q000662:veterinary; D009175:Mycoplasma Infections / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D009522:Newcastle disease virus / Q000276:immunology*; D011201:Poultry Diseases / Q000276:immunology* / Q000382:microbiology; D014422:Turkeys / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines