title: Kanamycin sulfate in the horse: serum, synovial fluid, peritoneal fluid, and urine concentrations after single-dose intramuscular administration.
abstract: Six healthy adult mares were given a single dose of kanamycin sulfate (200 mg/ml) IM at a dosage rate of 5 mg/kg of body weight. Kanamycin concentrations in serum, synovial fluid, peritoneal fluid, and urine were measured serially over a 48-hour period. The mean peak serum kanamycin concentration was 12.55 microgram/ml at 1 hour. Mean peak kanamycin concentrations in synovial fluid and peritoneal fluid were 7.25 microgram/ml and 9.27 microgram/ml at 2 hours and 3 hours, respectively. These concentrations decreased steadily in parallel with serum concentrations and were still measurable at 48 hours. Urine concentrations of kanamycin were relatively high, with a mean peak concentration of 80.51 microgram/ml at 1 hour.
mesh_terms: D000818:Animals; D001202:Ascitic Fluid / Q000032:analysis; D005260:Female; D006736:Horses / Q000378:metabolism*; D007273:Injections, Intramuscular; D007612:Kanamycin / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D013582:Synovial Fluid / Q000032:analysis
chemical_list: D007612:Kanamycin