[Action of the basic trypsin inhibitor on lymphocyte blastic transformation in vitro].
The effect of Basic-trypsin-inhibitor (BPTI) on the in vitro PHA-induced blastic transformation of lymphocytes is reported. Cultures of lymphocytes from healthy subjects were added with PHA, BPTI and PHA + BPTI; simple control-cultures were also performed. The blastic transformation was evaluated by morphologic method after 72 h incubation  at 37 degrees C. The results are compared with Wilcoxon's test; it was observed that BPTI reduces the PHA-induced blastic transformation, but it has no effect on cultures without PHA. The hypothesis that BPTI inhibits only PHA-stimulated lymphocytes is suggested.
D006801:Humans; D037102:Lectins / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D014361:Trypsin Inhibitors / Q000494:pharmacology*
D037102:Lectins; D014361:Trypsin Inhibitors
Azione dell'inibitore basico della tripsina (bpti) sulla blastizzazione linfocitaria in vitro.