title: Comparative immunogenicity of live influenza viruses and their solubilized neuraminidases: results of mouse protection experiments.
abstract: Antigenicity and immunogenicity of three influenza virus strains A/PR/8/34 (H1N1). A/Hong Kong/1/68 (H3N2) and A/Port Chalmers/1/73 (H-3H2) were assayed comparatively with their corresponding neuraminidase isolated by proteolysis, and with the recombinant virus X-42 (Heq1 N2). It was concluded that intranasal immunization of mice with live virus induced heterologous immunity. Except in homologous neuraminidase-vaccinated mice, the subunit always was shown less effective and demonstrated a significantly lower antibody response than the corresponding whole virus.
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000956:Antigens, Viral; D009980:Influenza A virus / Q000201:enzymology / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D051379:Mice; D009439:Neuraminidase / Q000276:immunology*; D013329:Structure-Activity Relationship
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D007252:Influenza Vaccines; D009439:Neuraminidase