title: Sodium oxacillin in the horse: serum, synovial fluid, peritoneal fluid, and urine concentrations after single-dose intramuscular administration.
abstract: Six healthy adult mares were given a single dose (25 mg/kg of body weight) of sodium oxacillin IM. Oxacillin concentrations in serum, synovial fluid, peritoneal fluid, and urine were measured serially over a 48-hour period. The mean peak serum oxacillin concentration was 9.75 microgram/ml at 0.5 hour after injection. Mean peak oxacillin concentrations in synovial and peritoneal fluids were 1.45 microgram/ml and 2.60 microgram/ml at 1 hour and 2 hours, respectively. These concentrations decreased in parallel with serum values and were not measurable at 48 hours. Urine concentrations of oxacillin were high, with a mean peak concentration of 2,790.2 microgram/ml at 0.5 hour.
mesh_terms: D000818:Animals; D001202:Ascitic Fluid / Q000032:analysis; D005260:Female; D006736:Horses / Q000378:metabolism*; D007273:Injections, Intramuscular; D010068:Oxacillin / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D013582:Synovial Fluid / Q000032:analysis
chemical_list: D010068:Oxacillin