Inhibition of lymph node metastasis of P388 leukemia by bestatin in mice.
Bestatin, a chemically defined immunostimulant of low molecular weight, suppressed the gradually-occurring lymph node metastasis of P388 leukemia in CDF1 mice when administered i.p. at the doses of 1 approximately 30 micrograms/mouse. It could not, however, suppress the established large metastasis of P388 leukemia. Lymph node cells isolated from the mice given bestatin i.p. at 1 and 30 microgram/mouse showed cytostatic activity against P388 leukemic cells in vitro than those from the untreated mice.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D005260:Female; D066298:In Vitro Techniques; D007930:Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D007941:Leukemia P388 / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008207:Lymphatic Metastasis / Q000517:prevention & control*; D051379:Mice; D008815:Mice, Inbred Strains
D000903:Antibiotics, Antineoplastic; D007930:Leucine; C012211:ubenimex