Influence of 6-metoxy-cumaranon-2-acetic acid and its derivatives on the process of humoral and cellular immunogenesis.
The influence of 6-metoxy-cumaranon-2-acetic acid and its four derivatives on the humoral and cellular immunogenesis was determined. The study of immunosuppressive properties included: the control of the level of peripheral blood lymphocytes, the estimation of transplantation immunity, GvH reaction, PFC production for SRBC and LPS and the determination of the number of cells possessing receptors for antigen, Fc fragment and complement. Furthermore, blast transformation of lymphocytes stimulated with PHA was estimated as well as the cytotoxic effect of sensitized lymphocytes. The results indicate immunosuppressive activity of acetamides HKCMF and HKCHF. They lowered the level of circulating lymphocytes, the number of cells possessing receptors for complement and they hindered PFC production for SRBC and LPS. Moreover, acetamide HKCHF weakened the cytotoxic activity of lymphocytes sensitized to alloantigens.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D003374:Coumarins / Q000494:pharmacology* / Q000633:toxicity; D007111:Immunity, Cellular / Q000187:drug effects*; D007166:Immunosuppressive Agents; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D011946:Receptors, Antigen / Q000032:analysis; D011951:Receptors, Complement / Q000032:analysis; D011961:Receptors, Fc / Q000032:analysis; D013329:Structure-Activity Relationship
D003374:Coumarins; D007166:Immunosuppressive Agents; D011946:Receptors, Antigen; D011951:Receptors, Complement; D011961:Receptors, Fc