title: [Immunoglobulin levels in the serum and saliva of patients with laryngeal cancer].
abstract: The relationship of the levels of immunoglobulins (A, M, G and As) in serum and saliva, tumor process advancement and type of therapy was studied in 92 patients with cancer of larynx. It was found that tumor process advancement is accompanied by a considerable rise in the serum level of IgA, a slighter increase in IgG and a decrease in IgM level. The saliva concentration of IgA (IgAs) was 2-2.5 times that in healthy controls. Preoperative radiation therapy with a total focal dose of 3,300- 4,000 rad was followed by slight changes in the concentration of A, M, G immunoglobulins, while saliva showed sharp drops in IgAs level, particularly, in cases of clinically-pronounced effect of radiation therapy. The levels of IgA and IgG in serum were equal to those in healthy controls 1 month after radical surgery, whereas the concentration of IgM remained below normal in half the cases. The saliva concentration of IgAs was close to that in healthy subjects.
mesh_terms: D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D007822:Laryngeal Neoplasms / Q000097:blood / Q000276:immunology* / Q000628:therapy; D012463:Saliva / Q000276:immunology*; D013997:Time Factors
chemical_list: D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins
vernacular_title: Soderzhanie immunoglobulinov v syvorotke i sliune u bol'nykh rakom gortani.