The mechanism of phenobarbitone potentiation of centrilobular hepatic necrosis.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004357:Drug Synergism; D064420:Drug-Related Side Effects and Adverse Reactions; D004579:Electron Transport; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D009336:Necrosis; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats
D003577:Cytochrome P-450 Enzyme System; D005978:Glutathione; D010634:Phenobarbital