The effect in vitro of high-density lipoprotein on hydrolysis of triacylglycerol by lipoprotein lipase.
In an incubation system in vitro with fully activated Intralipid as substrate, rat high-density lipoprotein inhibits the hydrolysis of triacylglycerol by lipoprotein lipase from rat adipose tissue, but does not inhibit hydrolysis by the enzyme from bovine milk. The pattern of inhibition suggests that substrate and high-density lipoprotein may compete for association with rat adipose-tissue lipoprotein lipase.
D000273:Adipose Tissue / Q000201:enzymology; D000818:Animals; D002417:Cattle; D006868:Hydrolysis; D066298:In Vitro Techniques; D008071:Lipoprotein Lipase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008075:Lipoproteins, HDL / Q000494:pharmacology*; D008297:Male; D008892:Milk / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism*
D008075:Lipoproteins, HDL; D014280:Triglycerides; D008071:Lipoprotein Lipase