[Stimulation of the renal transport of foreign substances following unilateral nephrectomy].
During the phase of compensation of parenchyma loss two different mechanisms can be stated causing an improvement of renal tubular transport capacity. Besides an increase of tubular transport ratio in kidney slices from nephrectomized rats an increased mass of kidney tissue participated in the augmented transport capacity. 24 h after unilateral nephrectomy TmPAH is elevated from 0.40 +/- 0.10 to 0.61 +/- 0.13 mg/min x g kidney weight. The simultaneous increase in slice-to-medium ratio of renal cortical slices demonstrate the increase in specific transport capacity of regenerating kidney tissue. Furthermore the increase in kidney mass is the reason for an elevated transport capacity. Stimulation of renal PAH excretion by repeated pretreatment with cyclopenthiazide shortened the phase of compensation and raised the extent of tubular transport capacity following partial loss of kidney tissue. The specific accumulation of PAH in renal cortical slices from nephrectomized, cyclopenthiazide pretreated rats is distinctly elevated 96 h after unilateral nephrectomy from 19.4 +/- 2.7 to 24.3 +/- 0.6 micrograms/g kidney weight. Obviously there are different mechanisms for the increased PAH transport caused by stimulation and by regeneration after unilateral nephrectomy, because additional effects can be stated in regenerating rats by additional stimulation of renal tubular transport.
D000618:Aminohippuric Acids / Q000378:metabolism*; D000818:Animals; D003518:Cyclopenthiazide / Q000494:pharmacology; D005260:Female; D007668:Kidney / Q000502:physiology; D007684:Kidney Tubules / Q000187:drug effects / Q000378:metabolism*; D009392:Nephrectomy; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration; D010130:p-Aminohippuric Acid / Q000378:metabolism*
D000618:Aminohippuric Acids; D003518:Cyclopenthiazide; D010130:p-Aminohippuric Acid
Stimulation des renalen Fremdstofftransportes nach unilateraler Nephrektomie.