Comparison of phospholipid profiles of primary adenocarcinoma in the lung and other organs.
Phospholipid profiles, particularly molecular structure of phosphatidylcholine, of human primary lung adenocarcinoma were compared with those of the histologically same type of carcinoma from other organs in order to search for a possibility that differentiates between primary and metastatic tumors in the lung. The saturated class, mainly containing palmitic acid at both positions, accounted for 20.8% of phosphatidylcholine in lung adenocarcinoma, whereas it accounted for only 6-10.7% in the adenocarcinoma of other organs. Adenocarcinoma of organs other than the lung had specific characteristics of unsaturated molecular classes of phosphatidylcholine for each organ. Stomach tumor had high contents of dienes and tetraenes with particularly high proportion of arachidonic acid at the 2-position. Breast tumor had a high content of monoenes, containing palmitoleic acid at the 2-position. Adenocarcinomas of rectum, colon and thyroid contained more dienes compared to lung adenocarcinoma.
D000230:Adenocarcinoma / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism; D003110:Colonic Neoplasms / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D012004:Rectal Neoplasms / Q000378:metabolism; D013274:Stomach Neoplasms / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000378:metabolism
D005227:Fatty Acids; D010169:Palmitic Acids; D010713:Phosphatidylcholines; D010743:Phospholipids; D019308:Palmitic Acid