On the relationship between cardiac output and peripheral arterial resistance.
The concept of 'whole body auto-regulation' is a somewhat unsatisfactory explanation of the increased peripheral arterial resistance which follows a rise in cardiac output in 'volume' forms of hypertension. This analysis suggests that the resistance change may be due to the sodium retention and increased cardiac output having a direct effect to alter haemodynamics of flow through the arterioles in such a way as to damage their walls, and so lead to the gradual development of structural arteriolar narrowing. Studies are presented in the DOCA/salt hypertensive rat consistent with this proposal.
D000818:Animals; D001158:Arteries; D002302:Cardiac Output; D003900:Desoxycorticosterone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics; D006973:Hypertension / Q000139:chemically induced; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000494:pharmacology; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D003900:Desoxycorticosterone; D012965:Sodium Chloride; D009638:Norepinephrine