Influence of tranexamic acid on tumour blood flow.
The influence on the intratumour blood flow distribution in a transplantable rat sarcoma by a potent antifibrinolytic drug, tranexamic acid, administered intraperitoneally for 3 or 10 days was studied by the intratumour distribution of intravenously injected 86Rb. A local Xenon clearance technique was used to study the direct effect of tranexamic acid on local tumour blood flow. local tumour blood flow and the intratumour blood flow distribution after administration of tranexamic acid for 3 days were unchanged compared to controls. Prolonged administration of tranexamic acid changed the intratumour blood flow distribution significantly towards low flow values. This might be one mechanism behind the inhibiting effect of tranexamic acid in tumour growth rate, previously observed in both experimental and clinical studies.
D000818:Animals; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D008748:Methylcholanthrene; D009368:Neoplasm Transplantation; D011868:Radioisotopes; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D012413:Rubidium; D012513:Sarcoma, Experimental / Q000098:blood supply* / Q000139:chemically induced; D014148:Tranexamic Acid / Q000494:pharmacology*; D014980:Xenon Radioisotopes
D003509:Cyclohexanecarboxylic Acids; D011868:Radioisotopes; D014980:Xenon Radioisotopes; D008748:Methylcholanthrene; D014148:Tranexamic Acid; D012413:Rubidium