Plasma and tissue distribution of adriamycin in patients with pelvic cancer.
The levels of adriamycin in plasma, ascitic fluid and normal and neoplastic tissues sampled during surgery of 3 patients with advanced pelvic cancer were measured by fluorimetry. The highest content of fluorescent compounds was found in tumoral masses in necrotic or scarcely viable tissue; viable and invasive tumor areas scored fluorescence levels comparable with normal adnexa. Ascitic fluid contained levels of fluorescence comparable to the last observed phase of plasma levels. Adipose and cutaneous tissue scored the lowest concentrations.
D000368:Aged; D001202:Ascitic Fluid / Q000032:analysis; D004317:Doxorubicin / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D009336:Necrosis; D010386:Pelvic Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D013050:Spectrometry, Fluorescence; D014018:Tissue Distribution
D004317:Doxorubicin