title: Choroidal detachment. Clinical manifestation, therapy and mechanism of formation.
abstract: One hundred and twelve eyes of 103 patients were analyzed during a 9 1/2-year period after surgical drainage of a choroidal (ciliochoroidal) detachment (CD). Choroidal detachment in five groups of postoperative patients was studied. CD after surgery for cataract, for cataract and glaucoma, and for glaucoma alone had different time courses, but in all of these, there were similar amounts of protein (67% of plasma protein concentration) in the suprachoroidal fluid (SCF). In marked contrast was a group of patients with intraoperative choroidal effusions and very little protein (18% of plasma concentration) in the SCF. Identified also was a chronic recurrent form of CD that usually persisted for more than three months. Three distinct mechanisms by which choroidal effusion is formed were recognized, (1) one with evidence for the effusion occurring through an intact isoporous membrane (groups 1-3); (2) a second in which hemorrhagic SCF appeared acutely or subacutely (groups 1 and 2) through a disrupted isoporous membrane; and (3) a third form, an intraoperative choroidal effusion in patients with elevated episcleral venous pressure. Increased filtration rate of serum through an intact choriocapillary membrane caused molecular sieving of serum proteins. Inflammation, infection, cataract formation, and corneal edema were uncommonly encountered. Indications for surgery and recommended surgical technique are outlined in detail.
mesh_terms: D001692:Biological Transport; D002387:Cataract Extraction / Q000009:adverse effects*; D002829:Choroid; D002924:Ciliary Body; D004322:Drainage; D005122:Exudates and Transudates / Q000502:physiology; D005901:Glaucoma / Q000601:surgery*; D006470:Hemorrhage / Q000150:complications; D006801:Humans; D011183:Postoperative Complications / Q000601:surgery; D014603:Uveal Diseases / Q000209:etiology / Q000503:physiopathology