[Plasma and tissues distribution of misonidazole (RO 07-0582) in the rat bearing a chimio induced tumor (author's transl)].
1. The hypoxic cell-radiosensitizing drug misonidazole or 2 nitro imidazole was administered by intraperitoneal way at a dose of 25 mg/100 g to Wistar rats bearing a chimio-induced sarcoma. Drug plasma and tissues concentrations were determined by HPLC analysis. The diffusion of the drug in different tissues and tumor was very short: plasmatic and tissular peak levels were obtained 10 to 30 min. after injection. 2. Misonidazole concentrations in muscle, brain, tumor, liver and kidney were 50%, 47%, 36%, 9% and 13% of plasma level. No significative difference of the drug concentration were observed between the center and the outside zone of the tumor. 3. However, half-life of misonidazole in the center of tumor was much shorter than in the outside of the tumor, demonstrating its radiosensitizing properties.
D000818:Animals; D006207:Half-Life; D008297:Male; D008920:Misonidazole / Q000097:blood / Q000378:metabolism*; D009368:Neoplasm Transplantation; D009593:Nitroimidazoles / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012208:Rhabdomyosarcoma / Q000378:metabolism*; D012513:Sarcoma, Experimental / Q000378:metabolism; D014018:Tissue Distribution
D009593:Nitroimidazoles; D008920:Misonidazole
Etude de la répartition plasmatique et tissulaire du misonidazole (RO 07-0582) chez le rat porteur d'un sarcome chimio-induit.