[Treatment and prophylaxis of amoebiasis. New therapeutics in view (author's transl)].
Problems posed by treatment of amoebiasis differ according to latitudes, safe immunologic reactions and technics of no invasive exploration allowed important progress, but diagnostic means are rarely disposable in Africa. Great progress of last ten years is owed to arrival of metronidazole and derivates under oral form and recently injectable. These therapeutics compose the base of treatment. In the first part, the author proposes a practice classification of different amoebicides in these groups; derivatives of the 5 nitro-imidazole, dehydroemetine, and other amoebicides. Structural characters, posology and the presentation of essential imidazole derivates are ouned up in a synoptic table. Pharmacokinetics characteristics, efficacy and secondary effects are studied afterwards. In a second part, indications and management are considered about means manifestations of amoebiasis.
D000563:Amebicides / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use; D004404:Dysentery, Amebic / Q000188:drug therapy / Q000517:prevention & control*; D006801:Humans; D008101:Liver Abscess, Amebic / Q000188:drug therapy
D000563:Amebicides
Traitement et prophylaxie des amibiases perspectives thérapeutiques nouvelles.