Craviten hydrolysis in plasma in vitro.
Craviten hydrolysis in vitro was studied in human, rat and canine plasma and erythrocytes. Craviten was degraded during the incubation with plasma and the hydrolysis was inhibited by trimethoxybenzoic acid, a metabolite of Craviten. Erythrocyte enzymes do not participate in the hydrolysis.
D000818:Animals; D004912:Erythrocytes / Q000378:metabolism; D005029:Ethylenediamines / Q000097:blood*; D005707:Gallic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D006207:Half-Life; D006868:Hydrolysis; D066298:In Vitro Techniques; D007700:Kinetics; D051381:Rats; D011919:Rats, Inbred Strains
D005029:Ethylenediamines; C030706:butobendin; D005707:Gallic Acid; C005854:3,4,5-trimethoxybenzoic acid