title: Abortion may sensitize the mother to HLA antigens.
abstract: The incidence of cytotoxic antibodies in relation to histories of abortions was analyzed in sera from 474 nulliparous pregnant women. In patients with previous spontaneous abortions, there is a higher incidence of positive sera than in primigravidae. Furthermore, patients with two or more prior abortions show a greater incidence of cytotoxic activity in their sera than women who have had only one abortion.
mesh_terms: D000022:Abortion, Spontaneous / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007518:Isoantibodies / Q000032:analysis; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013997:Time Factors
chemical_list: D006680:HLA Antigens; D007518:Isoantibodies