Suppressive effect of aluminium chloride administration on mouse lung carcinogenesis by dimethylnitrosamine.
Dimethylnitrosamine was administered to mice by ip injection once a week for 3 weeks and a high incidence of lung tumor was found 6 approximately 8 months after the final injection. In experiment I, the incidence of mice with lung tumors was 74% and the average number of nodules per mouse was 15.6 within 6.0 months after the final injection of dimethylnitrosamine. In mice given aluminium pretreatment, these values decreased to 65% and 6.7 (P less than 0.05), respectively. In experiment II, the incidence of mice with lung tumors was 100% and the average number of nodules per mouse was 8.7 within 7.5 months after the final injection of dimethylnitrosamine. In mice given aluminium pretreatment, these values decreased to 79% and 4.6 (P less than 0.05), respectively.
D000230:Adenocarcinoma / Q000378:metabolism; D000236:Adenoma / Q000378:metabolism / Q000648:ultrastructure; D000535:Aluminum / Q000494:pharmacology*; D000077410:Aluminum Chloride; D017607:Aluminum Compounds; D000818:Animals; D002277:Carcinoma / Q000378:metabolism / Q000648:ultrastructure; D002712:Chlorides; D004128:Dimethylnitrosamine; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced
D017607:Aluminum Compounds; D002712:Chlorides; D000077410:Aluminum Chloride; D000535:Aluminum; D004128:Dimethylnitrosamine