Effectiveness of Nissen fundoplication for gastroesophageal reflux in children as measured by 24-hour intraesophageal pH monitoring.
Intraesophageal 24-hr pH monitoring was performed on each of six children with severe symptomatic GER both before and after (mean, 10.1 mo.) fundoplication. The frequency and duration of reflux as measured by esophageal pH below 4.0 was less following fundoplication than in control patients (p less than 0.01). The 24-hr esophageal pH correlates more closely with GER than does measurement of the LESP. The duration to be the best available test which correlates with detection of reflux and correction following fundoplication. The Nissen fundoplication appears to effectively prevent GER.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004947:Esophagus / Q000601:surgery*; D005764:Gastroesophageal Reflux / Q000601:surgery*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008722:Methods; D011184:Postoperative Period; D013270:Stomach / Q000601:surgery*