title: Clinical, cytological and biological study of the intra-vaginal administration of oestriol (Ortho-Gynest) in post-menopausal patients.
abstract: Although some well-defined conditions require a replacement oestrogen therapy, local trophic disorders associated with the decrease of oestriol concentrations after surgical castration or menopause are corrected in a very satisfactory way by local oestrogen therapy. An initial treatment with 0.5 mg oestriol per day for 3 wk followed by a 4-wk maintenance therapy of 2 pessaries per week (2 x 0.5 mg) brings about a clinical cure and normalization of the maturation index in more than 95% of the 48 patients with surgical or natural menopause who received this treatment. The authors insist on the efficacy of this therapeutic approach.
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D001284:Atrophy; D002369:Castration; D002979:Climacteric / Q000187:drug effects*; D004958:Estradiol / Q000097:blood; D004964:Estriol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D014621:Vagina / Q000187:drug effects* / Q000473:pathology; D014627:Vaginitis / Q000188:drug therapy
chemical_list: D004958:Estradiol; D004964:Estriol