[Glucocorticoid receptors and leukemia (author's transl)].
Attempts made to establish a correlation between the level of glucocorticoid receptors in leucocytes of leukemic patients and any parameter of steroid sensitivity in vitro have been unsuccessful in most of the cases. These results are in part linked to the marked heterogeneity of the populations studied. In addition, differences of glucocorticoid receptors between circulating leucocytes and bone marrow cells suggest that examination of circulating cells does not accurately reflect the behaviour of the real target cell of glucocorticoid therapy.
D001853:Bone Marrow / Q000503:physiopathology; D006801:Humans; D007700:Kinetics; D007938:Leukemia / Q000097:blood*; D007962:Leukocytes / Q000502:physiology*; D011965:Receptors, Glucocorticoid / Q000502:physiology*; D011987:Receptors, Steroid / Q000502:physiology*
D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid
La détermination des récepteurs des glucocorticoïdes a-t-elle un intérêt dans les leucémies?