[Effect of Bromovincamine on noradrenaline and 5-hydroxytryptamine contents, and glucose metabolism in rat brain: analysis using spontaneously hypertensive rats (SHR) (author's transl)].
Effects of Bromovincamine (BV) on cerebral noradrenaline (NA) and 5-hydroxytryptamine (5-HT) contents, and glucose metabolism in the brain were studied using stroke-prone spontaneously hypertensive (SHR-SP), stroke-resistant spontaneously hypertensive (SHR), age-matched normotensive Wistar Kyoto (WKR) and Wistar rats. In the SHR-SP which have a low level of NA in the hypothalamus, a continuous administration of BV for 1 week induced a normalization of the hypothalamic NA content. Under the same experimental conditions, a tendency toward normalization of hypothalamic NA was also observed in SHR. 5-HT contents in the cerebellum, striatum, hypothalamus, midbrain and hippocampus of SHR showed a significant increase following a single injection of BV. Similarly, 5-HT contents in the cerebellum and cerebral cortex of Wistar, WKR and SHR showed a significant increase following a continuous administration of BV for 1 week. Both in vitro and in vivo administration of BV significantly inhibited the high concentration of K+ evoked glucose consumption in cerebral cortical slices from SHR, WKR and Wistar rats, whereas glucose consumption in cerebral cortical slices from SHR determined in the absence of high concentration of K+ increased significantly following continuous in vivo administration of BV. The present results suggest that BV may be an useful drug for improving abnormal cerebral metabolisms of NA, 5-HT and glucose.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects*; D005947:Glucose / Q000378:metabolism*; D006973:Hypertension / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis*; D014748:Vinca Alkaloids / Q000494:pharmacology*; D014749:Vincamine / Q000031:analogs & derivatives / Q000494:pharmacology*
D014748:Vinca Alkaloids; D012701:Serotonin; D014749:Vincamine; C033581:11-bromovincamine; D005947:Glucose; D009638:Norepinephrine