Immunization of mice with Trypanosoma rhodesiense exposed to ultraviolet irradiation.
Exposure time of Trypanosoma rhodesiense as short as 1 minute to ultraviolet (U.V.) light prevents the organisms from causing infection. Live trypanosome challenge of mice immunized with U.V.-irradiated trypanosomes results in sterile immunity. This allows a method for the induction of protective immunity to experimental trypanosomiasis which can be performed in most laboratories using U.V. germicidal lamps found in sterile hoods.
D000818:Animals; D007114:Immunization; D051379:Mice; D008810:Mice, Inbred C57BL; D014345:Trypanosoma / Q000528:radiation effects*; D014353:Trypanosomiasis, African / Q000276:immunology; D014466:Ultraviolet Rays