Effect of styrene on hepatic mixed function oxidases, glutathione content and glutathione-s-transferase activity in rats.
Effect of styrene administration (250, 450 and 900 mg/kg orally for 7 consecutive days) on hepatic mixed function oxidase (MFO) enzyme activities, glutathione content and glutathione-S-transferase activity were observed. Activity of aryl hydrocarbon hydroxylase and aniline hydroxylase was significantly enhanced at higher doses of styrene (450 and 900 mg/kg). A significant lowering of glutathione content accompanied with the inhibition of glutathione-S-transferase activity was also noticed at the highest dose of styrene (900 mg/kg).
D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D005037:Ethylmorphine-N-Demethylase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D013343:Styrenes / Q000494:pharmacology*
D013343:Styrenes; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D000815:Aniline Hydroxylase; D005037:Ethylmorphine-N-Demethylase; D005982:Glutathione Transferase; D005978:Glutathione