title: [Secretion, metabolism and transport of aldosterone during the neonatal period of the guinea pig].
abstract: Aldosterone-binding to plasma proteins was determined in the guinea-pig by equilibrium dialysis, and the metabolic clearance rate (MCR) of aldosterone was calculated from experiments in which the labelled hormone was infused at a constant rate into the circulation during the neonatal period; no specific aldosterone-binding protein was found in the plasma. The hormone was weakly bound to the albumine. The MCR of aldosterone (1/day/100 g body weight) was unchanged from birth to day 8, and its values were similar to those found in adults. Since there was no modification in aldosterone-binding to plasma proteins and no change in the MCR from birth to day 3, the high plasma aldosterone concentrations in the guinea-pig were probably related to intense adrenal activity.
mesh_terms: D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism; D003956:Dialysis; D006168:Guinea Pigs; D008657:Metabolic Clearance Rate
chemical_list: D001798:Blood Proteins; D000450:Aldosterone
vernacular_title: Sécrétion, métabolisme et transport de l'aldostérone dans la période néonatale chez le cobaye.