Pentoxifylline does not protect mice against hypoxia.
Pentoxifylline 12.5-200 mg/kg failed to increase the survival time of mice exposed to oxygen, 5%. Other measures have previously been shown to increase survival time in this model, probably by improving the ratio of energy supply to demand. This has been accomplished by either increasing cerebral blood flow or decreasing cerebral energy consumption. Contrary to previous reports, it thus seems unlikely that pentoxifylline favorably affects these factors, at least in this model.
D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004195:Disease Models, Animal; D004734:Energy Metabolism / Q000187:drug effects; D000860:Hypoxia / Q000401:mortality / Q000517:prevention & control*; D051379:Mice; D008815:Mice, Inbred Strains; D010431:Pentoxifylline / Q000494:pharmacology / Q000627:therapeutic use*; D013805:Theobromine / Q000031:analogs & derivatives*
D013805:Theobromine; D010431:Pentoxifylline