[Biochemical and histological studies on the exposure with concentrated oxygen. Special attention to the generation of peroxidized lipids (author's transl)].
In the present studies, rats are fed with four different kinds of diet; (i) normal diet, (ii) B2-deficient diet, (iii) B2-tetrabutyrate added normal diet, and (iv) B2-tetrabutyrate added B2-deficient diet. The number or rats in each group is 10 and the term of raising is 18 to 46 days. In the normal diet group, when exposed to 90% oxygen, cholesterol, triglycerides, and the TBA value are increased in blood serum. The addition of B2-tetrabutyrate in diets reduces these elevation. Through electron microscope observation, oxygen exposure leads to puffing of mitochondria and increasing lipofuscin granules in livers and lungs. The destruction of mitochondria is also observed in brain. The addition of B2-teterabutyrate reduces the destruction of mitochondria and suppresses formation of lipofuscin.
D000818:Animals; D001921:Brain / Q000648:ultrastructure; D008054:Lipid Peroxides / Q000096:biosynthesis* / Q000097:blood; D008055:Lipids / Q000097:blood; D008099:Liver / Q000648:ultrastructure; D008168:Lung / Q000648:ultrastructure; D008297:Male; D008928:Mitochondria / Q000648:ultrastructure; D010100:Oxygen / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012256:Riboflavin / Q000031:analogs & derivatives / Q000494:pharmacology; D012257:Riboflavin Deficiency / Q000378:metabolism
D008054:Lipid Peroxides; D008055:Lipids; C009175:riboflavin tetrabutyrate; D010100:Oxygen; D012256:Riboflavin