A study of the major Australian snake venoms in the monkey (Macaca fascicularis). II. Myolytic and haematological effects of venoms.
Rhesus monkeys were kept in a restraining apparatus and while conscious injected with the venoms of a range of Australian snakes. Although the action of restraining itself caused an elevation of the animals' plasma creatine kinase (C.K.), the rise was up to 5 times greater in envenomed monkeys. The venoms of the Tiger snake, Mulga, Beaked Sea snake, Rough-Scaled, Copperhead and Red-Bellied snakes were all powerfully myolytic, and those of the Taipan and Small-Eyed snake less so. No myolytic activity was found in the venoms of the Common Brown snake and Death Adder, and the results with Dugite, Gwardar and Small-Scaled snake venom were equivocal. Significant coagulation disturbances were produced by all venoms studied except those of the Small-Eyed and Rough-Scaled snakes. When first aid measures were used, the coagulation disturbances which developed after the release of the injected venom were significantly less than when no first aid was used. This finding, which was observed with all snake venoms studied, suggests that the procoagulant factor may be subject to some inactivation whilst immobilized at the injection site.
D000818:Animals; D001315:Australia; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors; D003402:Creatine Kinase / Q000097:blood; D004546:Elapid Venoms / Q000494:pharmacology*; D008252:Macaca fascicularis; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D009504:Neutrophils; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time
D001779:Blood Coagulation Factors; D004546:Elapid Venoms; D003402:Creatine Kinase