The effect of frusemide and piretanide on the renal clearance of gentamicin in man.
1 Gentamicin alone (dose 1 mg/kg) or in combination with frusemide (dose 0.25 mg/kg) or piretanide (dose 0.1 mg/kg) was administered intravenously to six healthy male volunteers. 2 Blood samples were collected at various times for 24 h and urine for up to 48 h. 3 Both diuretics increased the renal clearance of gentamicin during the period of the diuresis, without influencing either the glomerular filtration rate or the distribution of the antibiotic. 4 The results are discussed in relation to gentamicin-induced nephrotoxicity.
D000328:Adult; D004232:Diuretics / Q000494:pharmacology*; D004347:Drug Interactions; D005665:Furosemide / Q000494:pharmacology*; D005839:Gentamicins / Q000652:urine*; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D013449:Sulfonamides / Q000494:pharmacology*
D004232:Diuretics; D005839:Gentamicins; D013449:Sulfonamides; D005665:Furosemide; C015451:piretanide