Effect of enkephalins in the presence of the antibiotic bacitracin in the longitudinal muscle strip preparation from guinea-pig ileum.
The antibiotic bacitracin (5 x 10(-5) -4 x 10(-4) M) increase the inhibition of the contractile response caused by both enkephalin release and direct application of Met-enkephalin 5 x 10(-7) M in the longitudinal muscle strip preparation from guinea-pig ileum. This effect is attributed to an inhibition of enkephalin degrading peptidases by bacitracin.
D000818:Animals; D001414:Bacitracin / Q000494:pharmacology*; D004723:Endorphins / Q000494:pharmacology*; D004744:Enkephalin, Methionine; D004745:Enkephalins / Q000494:pharmacology*; D006168:Guinea Pigs; D007082:Ileum / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*
D004723:Endorphins; D004745:Enkephalins; D001414:Bacitracin; D004744:Enkephalin, Methionine