title: Chemoprophylaxis of vector-borne anaplasmosis with sustained-release boluses.
abstract: Sustained-release oxytetracycline boluses (20%) delivering 145 to 150 mg/bolus/day were administered to complement-fixation test-negative cattle at dosages of 2.0, 2.5, and 3.0 mg/kg of body weight. Subsequent challenge exposure of cattle with Dermacentor andersoni Stiles infected with Anaplasma marginale Theiler indicated that treatment with the dosage of 2.5 mg/kg prevented clinical anaplasmosis and that treatment with the dosage of 3.0 mg/kg prevented disease infection.
mesh_terms: D000712:Anaplasmosis / Q000517:prevention & control*; D000818:Animals; D001096:Arachnid Vectors / Q000382:microbiology; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D003692:Delayed-Action Preparations; D003870:Dermacentor / Q000382:microbiology; D005247:Feeding Behavior; D005260:Female; D010118:Oxytetracycline / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D003692:Delayed-Action Preparations; D010118:Oxytetracycline