Effect of selected intravitreal drugs after severe penetrating injury in rabbits.
The rabbit model of severe double penetrating posterior injury associated with a large vitreous hemorrhage was used to test the efficacy of selected chemotherapeutic agents in preventing vitreal membranes. Intravitreal injection of cytosine arabinoside, doxorubicin, or dexamethasone did not alter the frequency or severity of the resultant vitreal membranes.
D000818:Animals; D003561:Cytarabine / Q000494:pharmacology / Q000627:therapeutic use*; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use*; D004317:Doxorubicin / Q000494:pharmacology / Q000627:therapeutic use*; D005131:Eye Injuries / Q000188:drug therapy*; D008566:Membranes / Q000187:drug effects; D008854:Microscopy, Electron; D011817:Rabbits; D014822:Vitreous Body / Q000187:drug effects* / Q000648:ultrastructure; D014950:Wounds, Penetrating / Q000188:drug therapy
D003561:Cytarabine; D003907:Dexamethasone; D004317:Doxorubicin