On toxicity question of synthetic polymers and their extracts tested in vitro and in vivo.
The increasing use of polymer materials in medicine as much as the undesirable effects observed in patients during their application made us to study not only their functional properties but also their toxicological and biostability parameters, before their clinical application. Some of the aspects of this wide-ranging problem have been studied in our laboratory. Our aim was to try and identify the effect synthetic polymers and their extract have on different biological systems. The comparison of the results obtained through some of the biological methods was aimed at finding out to what extent such methods were suitable for testing of the polymer toxicity on living tissue.
D000268:Adhesiveness; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D062109:Dermatologic Surgical Procedures; D005260:Female; D006367:HeLa Cells; D066298:In Vitro Techniques; D007668:Kidney; D008297:Male; D011095:Polyethylenes / Q000633:toxicity*; D011108:Polymers / Q000633:toxicity*; D011143:Polyvinyl Chloride / Q000633:toxicity*; D011145:Polyvinyls / Q000633:toxicity*; D019736:Prostheses and Implants; D051381:Rats; D013094:Spermatozoa / Q000187:drug effects; D013552:Swine
D011095:Polyethylenes; D011108:Polymers; D011145:Polyvinyls; D011143:Polyvinyl Chloride