Time-course effects of adrenergic and cholinergic antagonists on systemic arterial blood pressure, heart rate and temperature in conscious squirrel monkeys.
Mean arterial blood pressure, heart rate, and rectal temperature were measured from conscious, chair-restrained squirrel monkeys prepared with chronically indwelling arterial and venous catheters and temperature probes to determine the magnitude and duration of the effects of acute intravenous injections of propranolol, phentolamine and methyl atropine. The data indicate a predominant influence of the sympathetic nervous system in the regulation of cardiovascular activity resting squirrel monkeys.
D000818:Animals; D001011:Aorta / Q000187:drug effects; D001286:Atropine Derivatives / Q000008:administration & dosage / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects*; D002427:Cebidae / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology*; D010646:Phentolamine / Q000008:administration & dosage / Q000494:pharmacology; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology; D012007:Rectum / Q000502:physiology; D012453:Saimiri / Q000502:physiology*; D013565:Sympatholytics / Q000494:pharmacology*; D013997:Time Factors
D001286:Atropine Derivatives; D010276:Parasympatholytics; D013565:Sympatholytics; C006649:methylatropine; D011433:Propranolol; D010646:Phentolamine