[Influence of 4-methylesculetol on the response of segments of isolated coronary arteries to adrenaline, in presence of pyrogallol].
The adrenaline (AD) induced relaxation in the smooth muscle is increased by bioflavonoids, possibly via cathecol-0-methyltransferase (COMT) inhibition. In order to test this hypothesis, we studied the influence of 4-methylesculetin (4-Me), alone or associated with ascorbic acid, on the response of isolated coronary strips to AD, in the presence of pyrogallol. Both 4-Me being enhanced by the addition of ascorbic acid. The effects were reduced or abolished in the presence off pyrogallol, a well known COMT inhibitor. It is concluded that 4-Me inhibits COMT, as other bioflavonoids.
D000818:Animals; D002394:Catechol O-Methyltransferase / Q000378:metabolism; D002417:Cattle; D003331:Coronary Vessels / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011748:Pyrogallol / Q000494:pharmacology*; D012603:Scopoletin / Q000494:pharmacology*; D014468:Umbelliferones / Q000494:pharmacology*
D005419:Flavonoids; D014468:Umbelliferones; D011748:Pyrogallol; D002394:Catechol O-Methyltransferase; D012603:Scopoletin; D004837:Epinephrine
Influenza del 4-metilesculetolo sulle risposte di segmenti di arterie coronarie isolate all'adrenalina, in presenza di pirogallolo.