Aqueous procaine penicillin G in the horse: serum, synovial, peritoneal, and urine concentrations after single-dose intramuscular administration.
Six adult mares were given a single dose of aqueous suspension procaine penicillin G (300,000 IU/ml) IM at a dosage of 22,000 IU/kg of body weight (15.4 mg of penicillin G/kg). Serum, synovial fluid, peritoneal fluid, and urine penicillin concentrations were measured serially over a 48-hour period. The mean peak serum penicillin concentration was 1.42 microgram/ml at 3 hours. Penicillin was detected in synovial fluid and peritoneal fluid, which obtained mean peak penicillin concentrations of 0.62 microgram/ml and 0.58 microgram/ml, at 4 hours and 3 hours, respectively. These concentrations steadily decreased in parallel with serum concentrations and were still measurable at 48 hours. Urine concentrations of penicillin were relatively high, with a mean peak concentration of 525.81 microgram/ml at 8 hours.
D000818:Animals; D001202:Ascitic Fluid / Q000032:analysis*; D005260:Female; D006736:Horses / Q000097:blood / Q000378:metabolism* / Q000652:urine; D007273:Injections, Intramuscular / Q000662:veterinary; D010402:Penicillin G Procaine / Q000032:analysis* / Q000097:blood / Q000652:urine; D013582:Synovial Fluid / Q000032:analysis*
D010402:Penicillin G Procaine