[Activity of nonspecific immunological factors and serum immunoglobulin levels in children with diabetes mellitus].
The activity of non-specific protection factors (complement titer, lysozyme level, completed phagocytosis index and serum immunoglobulin (IG) concentration) was studied in 100 children, aged 3 to 14 years: 70 with diabetes mellitus and 30 normal subjects. The results obtained indicate a decreased reactivity of the child organism in diabetes mellitus, the reduction degree being directly proportional to the main process severity and decompensation extent. Serum IG level in children, suffering from diabetes mellitus, is disturbed, i.e. high IgA concentration is often seen in the presence of normal IgM level and normal or decreased IgG content. Disimmunoglobulinemia is intensified within decompensation phase, depending on the pathological process duration and severity. The reduced IgG level in patients with severe diabetes apart from lower indices of non-specific immunity, stipulates pred disposition of children with diabetes mellitus to the secondary infection development. The indices studied may be used not only for characterizing the body immunobiological reactivity and protective mechanisms, but also for determining the disease severity and form.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003165:Complement System Proteins / Q000172:deficiency; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D004406:Dysgammaglobulinemia / Q000209:etiology; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000209:etiology; D017099:IgG Deficiency; D007070:Immunoglobulin A; D008297:Male; D009113:Muramidase / Q000172:deficiency; D010587:Phagocytosis
D007070:Immunoglobulin A; D003165:Complement System Proteins; D009113:Muramidase
Aktivnost' nespetsificheskikh faktorov zashchity i uroven' syvorotochnykh immunoglobulinov u deteĭ, bol'nykh sakharnym diabetom.