[Labeling of unnatural amino acids with 99mTc and tissue distribution of the labeled products in mice].
The selective affinity of amino acids for pancreas, due to its high rate of protein synthesis, has prompted us to synthesize new radio-labeled amino acids for pancreatic imaging. Labeling of 19 unnatural amino acids with 99mTc was tried in the usual way, and 10 labeled products were obtained with low yields. The highest distribution of radioactivity from all these labeled amino acids, which had been injected intravenously into mice, was found in the kidney, whereas little activity was found in the pancreas. Thier low distributions in stomach suggest little dissociation of the labeled amino acids into 99mTcO4- in mice. It is presumed that these labeled amino acids behave unlike their original acids in the body.
D000596:Amino Acids; D000818:Animals; D007553:Isotope Labeling / Q000379:methods*; D008297:Male; D051379:Mice; D013667:Technetium; D014018:Tissue Distribution
D000596:Amino Acids; D013667:Technetium