title: Antitumor agents. 49 tricin, kaempferol-3-O-beta-D-glucopyranoside and (+)-nortrachelogenin, antileukemic principles from Wikstroemia indica.
abstract: Bioassay-directed isolation of the antitumor extract of Wikstroemia indica (Thymelaeaceae) has led to the characterization of tricin, kaempferol-3-O-beta-D-glucopyranoside, and (+)-nortrachelogenin as the major antileukemic constituents. In addition, daphnoretin was identified as the potent antitumor principle in vivo against the Ehrlich ascites carcinoma growth in mice.
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D004224:Diterpenes / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D005663:Furans; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000494:pharmacology; D044949:Kaempferols; D017705:Lignans; D008297:Male; D051379:Mice
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D005419:Flavonoids; D005663:Furans; D044949:Kaempferols; D017705:Lignans; C020436:nortrachelogenin; D006139:Guaiacol; C001579:astragalin; C017769:tricin