Antineoplastic agents. 76. The sea urchin Strongylocentrotus droebachiensis.
An improved procedure based on centrifugation at 37,000 g has been developed for isolating the antineoplastic glycoprotein strongylostatin 1 from Strongylocentrotus droebachiensis (Müller). The green sea urchin has also been found to contain a second protein anticancer constituent designated strongylostatin 2. Treatment of the murine P388 lymphocytic leukemia with strongylostatin 2 resulted in 39-42% life extension at a dose of 4.5 mg/kg.
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D006023:Glycoproteins / Q000302:isolation & purification; D051379:Mice; D012617:Sea Urchins / Q000032:analysis*
D000970:Antineoplastic Agents; D006023:Glycoproteins; C504561:strongylostatin 2 protein, Strongylocentrotus droebachiensis; C033819:strongylostatin 1 protein, Strongylocentrotus droebachiensis