Effects of Caerulein on exocrine pancreatic secretion in sheep.
caerulein administered by slow intravenous infusion at increasing dosage rates (0.1, 1.0, 5.0 and 10.0 ng/kg/min X 30 min) stimulated pancreatic juice production in sheep as well as the protein content, the amylolytic, the lipolytic and proteolytic activities of pancreatic juice samples collected at 30 min intervals. A long lasting (300 min) infusion of a high dose of Caerulein by subcutaneous route elicited stimulatory effects with reduced intensities, slower onsets but more sustained durations than those produced by the same dose level administered intravenously.
D000688:Amylose / Q000378:metabolism; D000818:Animals; D002108:Ceruletide / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D050356:Lipid Metabolism; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D012756:Sheep / Q000502:physiology*
D011506:Proteins; D002108:Ceruletide; D000688:Amylose