Histological changes elicited in Schistosoma japonicum infected rabbits following curative chemotherapy with 4-isothiocyano-4'-nitro-diphenylamine (C9333-Go/CGP 4540).
New Zealand white rabbits were infected with 250 or 500 cercariae of the Philippine-Leyte strain of Schistosoma japonicum. 26 weeks later the experimental group were given one dose of 25 mg/kg formulated CGP 4540. Six weeks after dosing the treated rabbits and untreated controls were killed and examined. Parasitological cure was complete in all those treated. The liver and intestinal granulomata were greatly diminished in size and there was a dramatic decrease in the number of inflammatory cells in the hepatic tissue.
D000814:Aniline Compounds / Q000627:therapeutic use*; D000818:Animals; D004159:Diphenylamine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D007422:Intestines / Q000473:pathology; D017879:Isothiocyanates; D008099:Liver / Q000473:pathology; D011817:Rabbits; D012549:Schistosoma japonicum; D012552:Schistosomiasis / Q000188:drug therapy / Q000473:pathology*; D012556:Schistosomicides / Q000627:therapeutic use*; D013861:Thiocyanates / Q000627:therapeutic use*
D000814:Aniline Compounds; D017879:Isothiocyanates; D012556:Schistosomicides; D013861:Thiocyanates; D004159:Diphenylamine; C012391:amoscanate