[Effect of adrenaline administration on the interrelation between free fatty acid concentration in the blood and platelet accumulation in the circulatory bed of the myocardium].
Experiments on rabbits were made to specify the role of free fatty acids (FFA) in the platelet accumulation in the blood vessels of the myocardium during adrenaline administration. The lipolytic effect of adrenaline was modified by administering heparin or nicotinic acid. The platelet accumulation was evaluated from electron microscopy findings and from the change in the content of autologous platelets labeled with 51Cr. It was ascertained that administration of adrenaline brings about both the increase in the FFA in the blood and platelet accumulation in the blood vessels of the myocardium. In the presence of heparin administration, adrenaline leads to a more appreciable increase in FFA in the blood and platelet accumulation by the myocardium. After administering nicotinic acid the lipolytic action of adrenaline diminishes apart from the reduced platelet accumulation by the myocardium. It is suggested that FFA and platelet accumulation play an important role in the pathogenesis of catecholamine-induced injuries of the myocardium.
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D003331:Coronary Vessels / Q000187:drug effects*; D004347:Drug Interactions; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D006493:Heparin / Q000008:administration & dosage; D008066:Lipolysis / Q000187:drug effects; D009525:Niacin; D009539:Nicotinic Acids / Q000008:administration & dosage; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits
D005230:Fatty Acids, Nonesterified; D009539:Nicotinic Acids; D009525:Niacin; D006493:Heparin; D004837:Epinephrine
Vzaimosviaz' mezhdu soderzhaniem svobodnykh zhirnykh kislot v krovi i nakopleniem trombotsitov v krovenosnom rusle miokarda pri vvedenii adrenalina.