title: Evidence for heterosis in the HLA system.
abstract: The number of persons with homozygous HLA haplotypes in several groups of South American Indians was 39% less than that expected assuming unmodified equilibrium. In a subpopulation of 122 persons whose parents' HLA constitutions were known, there were 56% fewer homozygous persons than expected. This deficit was widely distributed in different haplotypes and different tribal groups.
mesh_terms: D000483:Alleles; D001938:Brazil; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D006238:Haploidy; D006720:Homozygote; D006801:Humans; D006823:Hybrid Vigor; D006824:Hybridization, Genetic; D007199:Indians, South American; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D006680:HLA Antigens