title: Subcutaneous and skeletal chordomoid nodules in an infant.
abstract: Multicentric subcutaneous and skeletal nodules with histologic features of chordoma developed over a period of 3 months in a black infant. Radiolucent intracranial lesions were demonstrated by pneumoencephalogram and computerized tomography scan. The patient received chemotherapy and the nodules regressed. After a follow-up of 7 years, there has been no recurrence of these chordomoid lesions and the child enjoys good health and normal growth and development. In retrospect, these nodules appear to be a benign, self-limited heterotopias and not malignancies. The cells with physaliphorous characteristics may represent unusual differentiation of fibroblasts rather than indicating notochordal origin.
mesh_terms: D001859:Bone Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D002817:Chordoma / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007223:Infant; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000473:pathology* / Q000648:ultrastructure