title: Stomach absorption of intubated insecticides in fasted mice.
abstract: Eight 14C-labeled insecticides representing diverse chemical classes were intubated into fasted mice whose stomachs were ligated at the pylorus. Absorption through the stomach was measured at 3 time intervals over a 60-min period and compared to similar absorption studies in the entire gastrointestinal tract. The percent of stomach absorption (as contrasted to total gastrointestinal absorption) varied from 29% (carbaryl) to 10% (nicotine). Distribution following stomach absorption was found to be similar to that in the gastrointestinal tract.
mesh_terms: D000042:Absorption; D000818:Animals; D005215:Fasting; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D007306:Insecticides / Q000378:metabolism*; D007441:Intubation, Gastrointestinal; D051379:Mice; D008813:Mice, Inbred ICR
chemical_list: D007306:Insecticides