title: [Retention and tolerance of the mammary gland of different drug forms of gentamycin in intramammary administration].
abstract: Tested were various drug forms of gentamycin sulphate (based on polyethyleneglycol, oil, and water solution) with regard to the tolerance of the mammary gland in cows and ewes. It was found that the oil-based preparations were much better tolerated as against those based on polyethyleneglycol. The aqueous solution of gentamycin sulphate, introduced in higher doses (up to 1200000 IU per udder quarter) slightly irritate the mammary parenchyma of cows as demonstrated with the presence of blood cell elements passed into the milk. A preparation that contained gentamycin sulphate (100000 IU) and hydrocortisone acetate, 0.2 (oil base) applied singly to lactating cows in an amount of 10 g(one syringe) maintained concentrations in most of the animals  up to the 4th day following treatment. In lactating sheep antibiotic concentrations in the milk persisted up to the 5 th day, while in sheep in a period of drying residual amounts were established in the course of more than 10 days.
mesh_terms: D000818:Animals; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000378:metabolism; D007774:Lactation / Q000187:drug effects; D008321:Mammary Glands, Animal / Q000378:metabolism*; D008414:Mastitis, Bovine / Q000378:metabolism; D008892:Milk / Q000187:drug effects; D011247:Pregnancy; D011817:Rabbits; D012756:Sheep; D013997:Time Factors
chemical_list: D005839:Gentamicins
vernacular_title: Zadŭrzhane i ponosimost ot mlechnata zhleza na razlichni lekarstveni formi ot gentamitsin pri intramamarno prilagane.