title: Isozymes of Culex p. fatigans. III. Genetics of leucine-amino-peptidase.
abstract: Zymograms of leucine-amino-peptidase (LAP) of the mosquito Culex pipiens fatigans Wiedemann (C. p. quinquefasciatus) showed 20 isozyme bands in the fourth instar larvae, 13 in the pupae and 3 in the older adults. Homozygous strains of Lap-1F (Fast) and Lap-1S (Slow) were isolated and linkage studies carried out. Lap-1F and Lap-1S allozymes act as codominant alleles, are sex linked and are located in linkage group I. The gene sequence is e-M-mar-Lap-1 (eye-gap, maroon-eye, leucine-amino-peptidase-1), and the linkage distances in the M-mar and mar-Lap-1 segments are 22.0 and 10.5, respectively. Gene frequency analysis of natural populations from Brazil and Pakistan showed the S allele was more frequent in the Brazilian populations whereas F was more frequent in the Pakistani populations. Fixation of F allele had occurred in two Pakistani populations.
mesh_terms: D000483:Alleles; D000818:Animals; D003465:Culex / Q000201:enzymology* / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D006720:Homozygote; D007527:Isoenzymes / Q000235:genetics; D007814:Larva / Q000201:enzymology; D007931:Leucyl Aminopeptidase / Q000235:genetics*; D008297:Male; D011679:Pupa / Q000201:enzymology
chemical_list: D007527:Isoenzymes; D007931:Leucyl Aminopeptidase