Enhancement of spiramycin concentration by bromhexin in the bovine nasal secretions.
Intramuscular injection of bromhexin (Quentan) results in increased bioavailability of spiramycin in nasal secretions. In the presence of a mucolytic agent, the area under the curve calculated according to spiramycin concentrations found in nasal secretions increases by 6%, 41% and 32% respectively in the course of three days of treatment. This potentiation reveals the interest involved in administering a combination of bromhexine and antibiotics in the treatment of infectious diseases of the respiratory tract.
D000818:Animals; D001682:Biological Availability; D001964:Bromhexine / Q000008:administration & dosage / Q000494:pharmacology*; D002417:Cattle / Q000378:metabolism*; D005260:Female; D007273:Injections, Intramuscular / Q000662:veterinary; D007933:Leucomycins / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D009093:Mucus / Q000378:metabolism; D009297:Nasal Mucosa / Q000378:metabolism*; D013268:Stimulation, Chemical
D007933:Leucomycins; D001964:Bromhexine