title: HLA antigens and HBV infection: evaluation in the chronic carrier state and in a large family.
abstract: HLA antigens were determined in 65 apparently well chronic carriers of HBsAg, in race-matched controls and in 42 members of a family with a high frequency of hepatitis B  virus infection. The only apparent significant association in the chronic carriers was negative, i.e., no HLA-B7 specificities were found among whites. B7 may confer resistance for whites to chronic infection with hepatitis B. In the family neither active (HBsAg) nor prior (anti-HBs) hepatitis B infection was associated with HLA specificities. HLA antigens in this family failed to provide a clue to the genetics of hepatitis B infection.
mesh_terms: D002353:Carrier State; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D006509:Hepatitis B / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D010375:Pedigree; D010641:Phenotype
chemical_list: D006680:HLA Antigens