Comparison of the excretion of sodium and meglumine diatrizoate at urography with simulated compression: an experimental study in the rat.
In the experimental model in the rabbit the excretion of sodium and meglumine diatrizoate, respectively, have been compared. Urographic density which was estimated through renal pelvic volume as calculated according to previous experiments (Owman 1978; Owman & Olin 1980) and urinary iodine concentration, is suggested to be more accurate than mere determination of urine iodine concentration and diuresis when evaluating and comparing urographic contrast media experimentally. More reliable dose optima are probably found when calculating density rather than determining urine concentrations. Of the examined media in this investigation, the sodium salt of diatrizoate was not superior to the meglumine salt in dose ranges up to 320 mg I/kg body weight, while at higher doses sodium diatrizoate gave higher urinary iodine concentrations and higher estimated density.
D000818:Animals; D003287:Contrast Media / Q000378:metabolism*; D003973:Diatrizoate / Q000031:analogs & derivatives* / Q000378:metabolism*; D003974:Diatrizoate Meglumine / Q000378:metabolism*; D007455:Iodine / Q000652:urine; D011817:Rabbits; D014517:Ureteral Obstruction / Q000378:metabolism; D014567:Urography
D003287:Contrast Media; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D007455:Iodine