Decrease in effects of muscimol on the dorsal root after repeated administration of diazepam in rats.
In in situ experiments on spinal rats transected at the C1 level and on non-spinal rats, muscimol (3 mg/kg, i.v.) depolarized the primary afferent fibers and diazepam (3 mg/kg, i.v.) potentiated this effect of muscimol. When diazepam was given for 14 days, the effect of muscimol was significantly reduced in non-spinal rats. These findings suggest that diazepam probably interacts with GABA-ergic mechanisms more closely in supraspinal regions of the rat.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009118:Muscimol / Q000037:antagonists & inhibitors*; D010080:Oxazoles / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D013126:Spinal Nerve Roots / Q000187:drug effects*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D010080:Oxazoles; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D003975:Diazepam; D001640:Bicuculline