The effect of diazane on the proliferation of human tumor cells.
The effect of the antitumorigenic agent diazane (1,2-bis-diazoacetylethane) in the cells of 30 human tumors cultured in vivo in diffusion chambers, implanted intraperitoneally into mice. Twenty-four hours after the introduction of diazane, a decrease in the proportion of DNA-synthesizing cells and the intensity of DNA synthesis to 30--50% of the control values is observed. By 48 hours, the values of these parameters had returned to the initial level.
D000970:Antineoplastic Agents; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D004273:DNA, Neoplasm / Q000096:biosynthesis; D003979:Diazonium Compounds / Q000494:pharmacology*; D006801:Humans; D008938:Mitosis / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D003979:Diazonium Compounds; C000279:diazan