Synthesis and biological properties of 5-benzoylamino-3-methyl-4-isoxazolocarboxylic acid derivatives.
A series of amides of 5-amino-3-methyl-4-isoxazolocarboxylic acid derivatives was synthesized and tested for antiinflammatory and antibacterial activity. P-etoxyphenylamid and p-chlorophenylamid of 5-benzoylamino-3-methyl-4-isoxazolocarboxylic acid displayed strong antiinflammatory and antibacterial effect. The most potent effect of these amides is accounted for the presence of benzoyl group in position 5 of isoxazole group.
D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D007555:Isoxazoles / Q000138:chemical synthesis*; D010080:Oxazoles / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D007555:Isoxazoles; D010080:Oxazoles