Haemorrhagic toxicosis in rats given butylated hydroxytoluene.
Vascular permeability, platelet function, blood coagulation and fibrinolytic activity were examined in Sprague-Dawley male rats given 1.20% butylated hydroxytoluene (BHT) in the diet for 1 week. BHT significantly increased the leakage of Evans blue from blood into epididymus. BHT inhibited the ADP-induced platelet aggregation and decreased the platelet factor 3 availability. Plasma prothrombin, factors IX, X, VII and VIII were decreased in rats given BHT. Fibrinolytic activity was little influenced by BHT-feeding.
D000818:Animals; D001774:Blood Chemical Analysis; D001777:Blood Coagulation / Q000187:drug effects; D002084:Butylated Hydroxytoluene / Q000633:toxicity*; D002199:Capillary Permeability / Q000187:drug effects; D005342:Fibrinolysis / Q000187:drug effects; D006470:Hemorrhage / Q000139:chemically induced*; D008099:Liver / Q000187:drug effects; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D002084:Butylated Hydroxytoluene