Mutagenicity studies of vinyl chloride.
Mutagenicity studies in both man and in test organisms clearly demonstrate positive mutagenic activity of vinyl chloride. In terms of the mutagenicity studies using a variety of in vitro procedures covering both eukaryotes and prokaryotes, positive effects were found. Cytogenetic in vivo studies in animals and in humans indicate not only somatic mutations, but also germinal effects with this chemical.
D000818:Animals; D002477:Cells / Q000187:drug effects*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006224:Cricetinae; D004812:Epidemiologic Methods; D005057:Eukaryotic Cells / Q000187:drug effects*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009154:Mutation; D011387:Prokaryotic Cells / Q000187:drug effects*; D051381:Rats; D014752:Vinyl Chloride / Q000009:adverse effects / Q000633:toxicity*; D014753:Vinyl Compounds / Q000633:toxicity*
D014753:Vinyl Compounds; D014752:Vinyl Chloride