[Effect of inhibitors of protein biosynthesis on integrative functions of the cerebral cortex during elaboration and consolidation of defensive conditioned reactions].
A conditioned defensive reaction was elaborated in non-anaesthetized non-immobilized rabbits and a study was made of the dynamics of background and evoked impulse activity of neurones in the somatosensory cortex under conditions of microionophoretic administration of puromycin and cycloheximide inhibitors of the translation stage of protein biosynthesis. It was found that the blockaders produce selective and reversible changes in the pattern of nerve cells responses to conditioned and reinforcing stimuli, in the frequency of background impulse activity and spikes amplitude. Direction and dynamics of the changes may not correlate. Effects of the inhibitors are frequently observed in a few seconds, being most pronounced in five to ten min. after their administration. Restoration of initial reactions takes usually place during 30 and more minutes. The data obtained are discussed in the light of "chemical" hypothesis of neurone integrative activity.
D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects* / Q000502:physiology; D003513:Cycloheximide / Q000494:pharmacology*; D004597:Electroshock; D008027:Light; D009419:Nerve Tissue Proteins / Q000502:physiology*; D014176:Protein Biosynthesis / Q000187:drug effects; D011691:Puromycin / Q000494:pharmacology*; D011817:Rabbits; D013003:Somatosensory Cortex / Q000187:drug effects*; D013016:Sound
D009419:Nerve Tissue Proteins; D011691:Puromycin; D003513:Cycloheximide
Vliianie ingibitorov biosinteza belka na integrativnye funktsii neĭronov kory mozga v protsesse vyrabotki i uprocheniia oboronitel'noĭ uslovnoĭ reaktsii.