title: Neuronal membrane D2-protein during rat brain ontogeny.
abstract: The D2-protein exists as a sialylated form in fetal and in perinatal rat brain, and as a desialylated form in adult rat brain. By crossed immunoelectrophoresis the concentrations and amounts of these froms were investigated during ontogeny of both forebrain and cerebellum. The concentration of sialylated D2-protein reached two peaks during ontogeny. The first peak occurred in forebrain around embryonic day 13, and in cerebellum just after birth. In both brain areas it coincided with the periods major neuronal migration. The second peak occurred in forebrain around postnatal day 6 and in cerebellum around postnatal day 20, during the initial period of synaptogenesis in both brain areas. Moreover, the desialylated form of D2-protein was found only in postnatal rats and it increased to a slight maximum at postnatal day 25 in forebrain, and postnatal day 35 in cerebellum. The findings are discussed in relation to the possible role of D2-protein as an adhesion molecule.
mesh_terms: D000375:Aging; D000818:Animals; D001921:Brain / Q000254:growth & development*; D002462:Cell Membrane / Q000378:metabolism; D005260:Female; D007123:Immunoelectrophoresis, Two-Dimensional; D008565:Membrane Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C023513:brain-specific protein D2, rat