title: HPLC-analysis and preliminary pharmacokinetic parameter estimations of chloroquine.
abstract: An HPLC method for the separate determination of chloroquine and its major metabolites has been developed. Separation was on an octadecyl RP column. Fluorimetric detection followed after on-line post-column buffering of the mobile phase to pH = 9.25. The method is highly selective for the compounds of interest with a detection limit down to 1 ng/ml. Preliminary data on the pharmacokinetics of chloroquine are reported, as obtained with this method. Kinetic parameters were estimated with the aid of the non-linear regression computer programme NON-LIN.
mesh_terms: D002738:Chloroquine / Q000031:analogs & derivatives / Q000032:analysis* / Q000097:blood; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D007741:Labetalol / Q000032:analysis
chemical_list: D002738:Chloroquine; C033490:N,N-dideethylchloroquine; D007741:Labetalol; C007278:desethylchloroquine