Determination of radiochemical purity and pharmacokinetic parameters of 99mTc-sulphur colloid and 99mTc-tin colloid.
Labelling yield and radiochemical purity, higher than 95%, of 99mTc-colloid preparations were determined by using the paper chromatography method. Less than 3% of labelled citric acid, added to the preparation as a buffer solution, has been found in 99mTc-sulphur colloid. High radiochemical purity and optimum size of colloid particles has also been proved by biodistribution studies on experimental animals. The analysis performed has shown that more than 50% of 99mTc-colloid preparations excreted by urine is 99mTcO-, the remaining past 50% being protein bound 99mTc. Biological half-time of excretion of the fast phase is the same for both preparations, i.e. 10 min, while for the slow component it is 120 min in 99mTc-S-colloid and 160 min in 99mTc-Sn colloid.
D000818:Animals; D006207:Half-Life; D007700:Kinetics; D051381:Rats; D011933:Reagent Kits, Diagnostic / Q000592:standards*; D013455:Sulfur / Q000378:metabolism / Q000592:standards*; D013667:Technetium / Q000378:metabolism / Q000592:standards*; D017556:Technetium Compounds; D013671:Technetium Tc 99m Sulfur Colloid; D014001:Tin / Q000378:metabolism / Q000592:standards*; D017971:Tin Compounds; D014018:Tissue Distribution; D015022:Yugoslavia
D011933:Reagent Kits, Diagnostic; D017556:Technetium Compounds; D017971:Tin Compounds; C033493:technetium Tc 99m tin colloid; D013671:Technetium Tc 99m Sulfur Colloid; D013455:Sulfur; D013667:Technetium; D014001:Tin