[Effect of cycloheximide on glucan biosynthesis in the growth process of Saccharomyces carlsbergensis yeasts].
Biosynthesis of alkali-acid-insoluble beta-glucan was studied in the course of growth of the yeast Saccharomyces carlsbergensis IBPM Y366. Synthesis of this important component of the cell wall was shown to depend on the stage of the cultural growth. The rate of 14C-glucose incorporation into the glucan fraction was maximal at the beginning and in the middle of the logarithmic growth phase. Cycloheximide, an inhibitor of protein synthesis, at a concentration of 10 micrograms/ml inhibited glucan synthesis at the beginning and by the end of the logarithmic growth phase, but stimulated synthesis of this polymer in the middle of the logarithmic phase of growth of this organism.
D002473:Cell Wall / Q000187:drug effects / Q000378:metabolism; D003513:Cycloheximide / Q000494:pharmacology*; D005936:Glucans / Q000096:biosynthesis*; D012440:Saccharomyces / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism
D005936:Glucans; D003513:Cycloheximide
Vliianie tsiklogeksimida na biosintez gliukana v protsesse rosta drozhzheĭ Saccharomyces carlsbergensis.