title: Lead exposure and behavioral changes: comparisons of four occupational groups with different levels of lead absorption.
abstract: The association between lead absorption and objective psychological performance tests in five groups with different levels of lead absorption was studied in the following groups: (1) a control, non-lead-exposed group; (2) cable splicers, (3) cable manufactures, and (4) secondary lead smelter workers. The following performance tests were used: Block Design, Digit Symbol, and Embedded Figures. Age-corrected performance test scores and the average of three test scores (INDEX) were used throughout. A significant association between performance tests scores and increased lead absorption was found. Zinc protoporphyrin level was a more "powerful" (in the statistical sense) indicator of lead-induced CNS effects than blood lead levels. This study provides additional evidence that neurotoxic effects associated with occupational exposure to lead can be demonstrated by means of performance tests. It has been known and widely accepted that increased lead absorption is associated with "non-specific" subjective symptoms: tiredness, sleep disturbance, irritability, etc. Psychometric techniques (including an appropriate statistical analysis strategy) are highly sensitive for the early detection of CNS neurotoxicity, such as metal toxicity. Moreover, even in lead-exposed but asymptomatic individuals, a significant correlation (negative) between test scores and levels of lead absorption could be detected. It is concluded that workers exposed to lead at levels considered "safe" might be at risk of developing brain dysfunction with long term exposure.
mesh_terms: D006801:Humans; D007854:Lead / Q000097:blood; D007855:Lead Poisoning / Q000523:psychology*; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced* / Q000523:psychology; D009790:Occupations; D011524:Protoporphyrins / Q000097:blood; D011581:Psychological Tests; D011596:Psychomotor Disorders / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D011524:Protoporphyrins; C017803:zinc protoporphyrin; D007854:Lead