A family with congestive cardiomyopathy.
In this family with congestive cardiomyopathy the lesion, a characteristic interstitial fibrosis with a high elastic tissue content, was defined at autopsy in 3 cases, and 3 further members may have been affected. The cases defined at autopsy all had long-standing arrhythmia and had suffered a cerebrovascular accident, probably secondary to endocardial fibroelastosis. The possibility that the myocardial cell changes may have been secondary to those in the interstitium is discussed. Ultrastructural X band changes were demonstrated 5 1/2 and 26 h postmortem.
D000328:Adult; D001145:Arrhythmias, Cardiac / Q000209:etiology; D009202:Cardiomyopathies / Q000150:complications / Q000235:genetics* / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000209:etiology; D004699:Endocardium / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology / Q000648:ultrastructure