Inhibition of steroidogenesis in isolated rat adrenal cells by glutethimide congeners.
A series of glutethimide congeners produce concentration-dependent inhibition of corticosterone production by a suspension of isolated rat adrenal cells. The dextro-rotatory antipode of aminoglutethimide is more potent than its levo enantiomer in inhibiting corticosterone production in this system. Glutethimide, its metabolite glutaconimide, and congeners including those with anti-convulsant activity, 4-hydroxyglutaconimide and 4-aminoglutethimide, have all demonstrated concentration-dependent inhibition of corticosterone production by isolated rat adrenal cells.
D000311:Adrenal Glands / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D003345:Corticosterone / Q000096:biosynthesis; D003864:Depression, Chemical; D005984:Glutethimide / Q000031:analogs & derivatives* / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D013256:Steroids / Q000096:biosynthesis*
D013256:Steroids; D005984:Glutethimide; D003345:Corticosterone