[Hypotensive effects of practolol and atenolol after blood-brain barrier lesion in normotensive and hypertensive rats].
Practolol (15 mg/kg i.c.) and atenolol (3 mg/kg i.v.) induced in rats hypotensive effects different from one group to another. However these hypotensive effects were always more important in hypertensive than in normotensive animals. IN Okamoto rats, hypotensive effect of atenolol increased with the age of the animals. In normotensive rats, atenolol had no effect whatever the animal age. Evans blue injected by intracarotid route in normotensive and hypertensive rats showed an increased permeability in Okamoto rats blood-brain barrier. After lesion of blood-brain barrier by intracarotid injected cetrimonium, hypotensive effect of the two beta-blocking drugs appeared in both normotensive and hypertensive rats, with a greater degree than in control rats.
D000818:Animals; D001262:Atenolol / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D001812:Blood-Brain Barrier / Q000187:drug effects*; D002555:Cerebrospinal Fluid / Q000502:physiology; D002593:Cetrimonium Compounds / Q000494:pharmacology; D006973:Hypertension / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D011217:Practolol / Q000627:therapeutic use*; D011412:Propanolamines / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains / Q000502:physiology
D002593:Cetrimonium Compounds; D011412:Propanolamines; D001262:Atenolol; D011217:Practolol
Effets hypotenseurs du practolol et de l'anténolol après lésion de la barrière hémato-encéphalique chez les rats normotendus et hypertendus.