Xanthocillin X monomethyl ether, a potent inhibitor of prostaglandin biosynthesis.
Xanthocillin X monomethyl ether, known as an antiviral antibiotic, was isolated as a potent inhibitor of Dichotomomyces cejpii. The compound inhibited prostaglandin synthesis from 14C-arachidonic acid in rabbit kidney microsomes by 50% at a concentration of 0.2 microM, while prostaglandin synthesis by microsomes of ram seminal vesicle was inhibited by 50% at 20 microM. The inhibition of xanthocillin X monomethyl ether was reversible. Of the enzymatic steps involved in the synthesis of prostaglandins and thromboxanes tested, conversion of arachidonic acid into prostaglandin H2 was specifically inhibited by xanthocillin X monomethyl ether. Anti-inflammatory activity of this antibiotic on carrageenan-induced oedema in the rat foot was, however, not detectable.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002070:Butadienes / Q000494:pharmacology*; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011453:Prostaglandins / Q000096:biosynthesis*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012756:Sheep
D000900:Anti-Bacterial Agents; D002070:Butadienes; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; C033793:xanthocillin X monomethyl ether; D007213:Indomethacin