[Two cases of skin pigmentation in association with minocycline therapy (author's transl)].
Report of two cases of skin pigmentation during minocycline therapy. Examination showed confluent blue-gray oval patches on the anterior part of the legs, occurring after ingestion of respectively 12 g and 100 g of minocycline. Microscopic examination of each case was identical and showed two lesions: increase in the amount of melanine deposition in the basal layer of the epidermis; presence of brown-black pigment at all the level of the dermis but specially near the sweet glands. This pigment was strongly positive with Perls' stain. Electron microscopic examination showed a finely granular pigment exclusively intracellular in dermis fibroblast and macrophage. This pigment seemed to contain mainly hemodiderine.
D006485:Hemosiderin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000009:adverse effects*; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000473:pathology; D012867:Skin / Q000473:pathology / Q000648:ultrastructure; D013754:Tetracyclines / Q000009:adverse effects*
D013754:Tetracyclines; D006485:Hemosiderin; D008911:Minocycline
Deux cas de pigmentation cutanée au cours de traitements par la minocycline.