title: Measurement of locomotor activity in hyperalgesic rats as an objective method for testing the antialgesic activity of drugs.
abstract: The registration of locomotor activity in hyperalgesic rats has been shown to be a simple and objective method to demonstrate the antialgesic activity of NSAI. Aspirin-like drugs significantly antagonize the pain-produced reduction in motility of hyperalgesic rats. It has also been demonstrated that new potent anti-inflammatory methanesulfonanilides, which do not inhibit PG-synthesis in vitro and are almost inactive in Writhing models, exhibit potent antialgesic activity in this model.
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects*; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D007213:Indomethacin