Structural specificity of the inhibition of serotonin accumulation in rat lung slices.
The structural specificity required for the inhibition of 5-HT accumulation in rat lung slices was determined using compounds possessing a single structural modification of the 5-HT molecule. The structural modifications involved the indole ring nitrogen atom, the alpha-carbon atom to the sidechain amine, the sidechain amine, and the substitution pattern of the indole nucleus.
D000818:Animals; D066298:In Vitro Techniques; D008168:Lung / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D012702:Serotonin Antagonists; D012701:Serotonin