title: [Hypoparathyroidism and Addison's disease with moniliasis: report of two cases in childhood (author's transl)].
abstract: Two pediatric cases are described presenting a conjunction of Addison's disease and hypoparathyroidism. One of the two cases also exhibits moniliasis of the oral cavity (Whitaker's disease). A full report is given of the symptoms and of the laboratory analyses which have motivated the diagnosis, and of the endocrinological function tests which were intended to confirm the diagnosis. The clinical process and the therapeutic criteria adopted are subsequently reported. A discussion follows focusing on the possible causes of the coexistence of the immunological defect and of the endocrinous deficiencies which are typical of the syndrome. Pathogenetic priority is attributed to the immunological defect which induces a autoimmune lesion of the endocrinous glands concerned.
mesh_terms: D000224:Addison Disease / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D002177:Candidiasis / Q000150:complications*; D002648:Child; D003900:Desoxycorticosterone / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007037:Hypothyroidism / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D012397:Rosette Formation
chemical_list: D007136:Immunoglobulins; D003900:Desoxycorticosterone; D006854:Hydrocortisone
vernacular_title: Ipoparatiroidismo e Addison con moniliasi: descrizione di due casi in età pediatrica.