The effect of testosterone administration on lead induced zincprotoporphyrin in blood concentration in castrated male rabbits.
The influence of testosterone propionate on the concentration of zincprotoporphyrin in blood (ZPP) of castrated lead treated rabbits was investigated. The experimental design allowed comparison of the relative ZPP increase (RZI) in testosterone treated and non testosterone treated rabbits. Testosterone was administered by subcutaneous injection of 3 mg/kg body weight/day for 7 consecutive days directly prior to the lead exposure, which was performed by subcutaneous injection of 0.50 mg lead acetate/kg body weight, three times a week for 7 weeks. No effect was found on the hemoglobin concentration (Hb) and hematocrit (Ht) and on the increase of body weight during the experiment. But the increase of RZI in the non testosterone treated rabbits was significantly steeper and earlier than in the testosterone treated group. The possible consequences of the findings had been further commented on.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002369:Castration; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D007855:Lead Poisoning / Q000097:blood*; D008297:Male; D011166:Porphyrins / Q000097:blood*; D011524:Protoporphyrins / Q000097:blood*; D011817:Rabbits; D013739:Testosterone / Q000494:pharmacology*
D006454:Hemoglobins; D011166:Porphyrins; D011524:Protoporphyrins; C017803:zinc protoporphyrin; D013739:Testosterone