Postimplantation development of CB-induced triploid mouse embryos.
By subjecting A strain eggs at the time of fertilization and polar body extrusion to 5 micrograms/ml cytochalasin B, digynic triploidy was produced in 80% fertilized eggs. Triplonucleate eggs were transplanted to recipients and examined between 9-11th day of pregnancy. Development of triploid mouse embryos up to day 7 is normal and most embryos form early egg cylinder. At day 8 the embryonic part of the cylinders is under-developed and later development fails to form an embryo. Development of foetal membranes is much less affected, CB-induced triploids survive to 10th- day of pregnancy.
D000818:Animals; D003571:Cytochalasin B / Q000494:pharmacology; D004624:Embryo Transfer; D047108:Embryonic Development; D005260:Female; D051379:Mice; D008805:Mice, Inbred A / Q000196:embryology*; D009865:Oocytes / Q000187:drug effects; D011123:Polyploidy; D011247:Pregnancy
D003571:Cytochalasin B