title: Myocardial infarction. Changes in the concentrations of high-energy compounds and free amino acids in erythrocytes.
abstract: Quantitative determination of the nucleotides AMP, ADP, ATP, GTP, NAD, NADP, 2,3-DPG and the free amino acids Lys, His, Gly, Ala, Val, Met, Phe, Tyr, Pro, Thr, Ser, Glu, Asp in erythrocytes was carried out in early and late stages of myocardial infarction. It was found that in erythrocytes, in the early stage of myocardial infarction, the concentrations of AMP, NADP and 2,3-DPG increased, whereas those of ADP, ATP, GTP and NAD decreased. In the third week of the disease the concentrations of AMP, ADP, NADP, and especially 2,3-DPG remained high, while those of ATP and GTP shifted towards the control. The concentrations of His, Gly, Ala, Val, Met, Phe, Thr and Glu increased, while those of Tyr, Ser and Asp decreased in the first stage of myocardial infarction. At the later stage of the illness (21 days) the concentrations of free amino acids returned to normal.
mesh_terms: D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate / Q000097:blood; D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000097:blood*; D004163:Diphosphoglyceric Acids / Q000097:blood; D004912:Erythrocytes / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D009711:Nucleotides / Q000097:blood*
chemical_list: D000596:Amino Acids; D004163:Diphosphoglyceric Acids; D009711:Nucleotides; D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate