Effects of ethambutol on phospholipid metabolism in Mycobacterium smegmatis.
Soon after Mycobacterium smegmatis was exposed to ethambutol, the synthesis of cardiolipin and phosphatidylinositol dimannoside declined. The synthesis of phosphatidylethanolamine continued, but the drug caused this phospholipid to leak out of the cells.
D002308:Cardiolipins / Q000378:metabolism; D004977:Ethambutol / Q000494:pharmacology*; D009161:Mycobacterium / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D013997:Time Factors
D002308:Cardiolipins; D010716:Phosphatidylinositols; D010743:Phospholipids; D004977:Ethambutol