[Culture of clone-forming cells from human tumours and its practical applications (author's transl)].
Tumoral stem cells capable of multiplying can be selected from human tumours by in vitro culture techniques. These are the cells which renew the tumour and form metastases. Placed in a suitable agar medium, they give birth to cellular clones. The selection of clone-forming cells from human tumours makes it possible to devise chemograms, as has successfully been done in the U.S.A. by the Salmon and von Hoff teams. Working on a fairly large number of different cancers and using in vitro tests in the presence of drugs, these scientists were able to predict chemosensitivity and chemoresistance in 62 to 96% of tumours. The new techniques and results are presented and discussed.
D000328:Adult; D000970:Antineoplastic Agents / Q000494:pharmacology; D002478:Cells, Cultured; D002999:Clone Cells / Q000166:cytology* / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology*
D000970:Antineoplastic Agents
La culture des cellules de tumeurs humaines et ses applications cliniques.