[Effect of tubaside and sodium succinate on oxidative phosphorylation and p-hydroxylation in the liver].
Tubaside causes disturbances in oxidative phosphorylation of the liver mitochondria. Sodium succinate administered during tubaside intoxication favours normalization of the oxygen uptake rate in state 3 and the ADP phosphorylation rate. Sodium succinate weakens the toxic effect of tubaside and favours normalization of p-hydroxylation in the liver. The animals, which were given tubaside in combination with sodium succinate are characterized by a higher survival rate.
D000818:Animals; D006168:Guinea Pigs; D006900:Hydroxylation; D007538:Isoniazid / Q000494:pharmacology*; D007700:Kinetics; D008930:Mitochondria, Liver / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D013386:Succinates / Q000494:pharmacology*; D019802:Succinic Acid
D013386:Succinates; D019802:Succinic Acid; D007538:Isoniazid
Vliianie tubazida i suktsinata natriia na okislitel'noe fosforilirovanie i p-gidroksilirovanie v pecheni.