Effects of N-acetyl-L-carnosine aluminum (CL-1700) on various acute gastric lesions and gastric secretion in rats.
Effects of a newly synthesized compound, N-acetyl-L-carnosine aluminum (CL-1700), on the formation of various types of acute gastric lesions were studied in rats. CL-1700 at 300 or 1,000 mg/kg (p.o.) significantly inhibited Shay ulcers and water-immersion stress- and aspirin-induced erosions in pylorus-ligated rats, and indomethacin- or phenylbutazone-induced erosions. CL-1700 had a weak effect on water-immersion stress-induced erosions in rats with an intact pylorus. CL-1700 at 100 or 300 mg/kg (i.p.) significantly inhibited Shay ulcers and water-immersion stress-induced erosions in rats with an intact pylorus. However, this compound (i.p.) had no effect on aspirin- and indomethacin-induced gastric erosions. CL-1700 at 1,000 mg/kg (i.d.) significantly reduced the gastric acid output in pylorus-ligated rats but at 300 or 1,000 mg/kg (p.o.) increased the volume, pepsin output and raised the pH value. The effects of CL-1700 on experimental gastric lesions were slightly weaker than those of aluminum sucrose sulfate but almost equal to or better than those of cimetidine. However, the effects of CL-1700 were much more potent than those of gefarnate. As CL-1700 appears to be a promising new anti-gastric lesion agent, the mechanisms of action are now under investigation.
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001241:Aspirin / Q000009:adverse effects; D002336:Carnosine / Q000031:analogs & derivatives / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000378:metabolism*; D007213:Indomethacin / Q000009:adverse effects; D008297:Male; D010653:Phenylbutazone / Q000009:adverse effects; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000187:drug effects*; D013276:Stomach Ulcer / Q000188:drug therapy; D013312:Stress, Physiological / Q000150:complications
D000897:Anti-Ulcer Agents; D004151:Dipeptides; C033681:N-acetylcarnosine; D002336:Carnosine; D010653:Phenylbutazone; D001241:Aspirin; D007213:Indomethacin