Synthesis and biological activity of some structural analogs of platelet-activating factor (PAF-acether).
Platelet-activating factor (PAF-acether), a mediator of anaphylaxis and inflammation, is a 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine. Some analogs of PAF-acether were prepared by total synthesis or by partial synthesis from commercially available phospholipids and tested for platelet aggregating activity. This study indicated that the ether linkage at the position 1 of sn-glycerol and the short acyl chain at position 2 are structural features required for biological activity.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D066298:In Vitro Techniques; D008244:Lysophosphatidylcholines / Q000138:chemical synthesis* / Q000494:pharmacology; D010743:Phospholipids / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D013329:Structure-Activity Relationship
D008244:Lysophosphatidylcholines; D010743:Phospholipids; D001241:Aspirin