title: [Contribution of sequential scintigraphy with 131I-BSP to the differential diagnosis of jaundice (author's transl)].
abstract: Patients with constitutional hyperbilirubinemia and with extra intrahepatic cholestasis have been explored by means of sequential scintigraphy, with the following results: 1. in Gilbert's syndrome liver uptake and output of 131I-BSP were normal; 2. in the Dubin-Johnson syndrome liver uptake and plasma clearance of 131I-BSP were normal; the substance was retained for a long period (2 hrs) in the liver without any tendency to be excreted; 3. in the Rotor syndrome 131I-BSP uptake was delayed and liver clearance prolonged; 4. in total biliary obstruction no intestinal activity could be recorded even in the late registrations (the latest after 24 hrs); 5. in partial extrahepatic biliary obstruction there was a normal liver uptake with an abnormal retention in the choledochus and a delayed excretion (more than 2 hrs); and 6. in intrahepatic cholestasis 131I-BSP liver uptake, retention and excretion were delayed; differentiation of these cases from total biliary obstruction is difficult. Late determinations, the last 24 hrs after injection of the tracer, were performed in these cases, in order to exclude a total obstruction with parenchymal injuries, by assessing the enteral output.
mesh_terms: D003937:Diagnosis, Differential; D005878:Gilbert Disease / Q000000981:diagnostic imaging; D006801:Humans; D006933:Hyperbilirubinemia, Hereditary / Q000000981:diagnostic imaging; D007457:Iodine Radioisotopes; D007565:Jaundice / Q000000981:diagnostic imaging*; D007566:Jaundice, Chronic Idiopathic / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D013448:Sulfobromophthalein
chemical_list: D007457:Iodine Radioisotopes; D013448:Sulfobromophthalein
vernacular_title: Der Beitrag der sequentiellen Szintigraphie mit 131J-BSP zur Ikterus-Differentialdiagnose.