Failure of drugs acting on H2-receptors to modify plasma prolactin levels in pituitary adenomas: evidence for a suprapituitary locus of action.
Cimetidine, which strongly stimulates prolactin release in healthy man, was unable to modify prolactin levels in prolactin-secreting pituitary adenomas. Furthermore, the infusion of 5-methylhistamine, an H2-receptor selective agonist, was equally ineffective. The results of these experiments together with the data reported in the literature suggest that H2-receptors modulate prolactin secretion at a hypothalamic level.
D000236:Adenoma / Q000097:blood*; D002927:Cimetidine / Q000494:pharmacology*; D005260:Female; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects*; D008761:Methylhistamines / Q000494:pharmacology*; D010911:Pituitary Neoplasms / Q000097:blood*; D011388:Prolactin / Q000097:blood*; D011968:Receptors, Histamine / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects*
D006146:Guanidines; D008761:Methylhistamines; D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D002927:Cimetidine; D011388:Prolactin