Adenosine contracts the isolated rat tail artery by releasing endogenous 5-hydroxytryptamine.
Adenosine (10(-4)-10(-3) M) contracted the isolated rat tail artery. This effect exhibited rapidly developing tachyphylaxis. Methysergide (10(-7) M) prevented the contractile response to adenosine and 5-hydroxytryptamine (5-HT) without affecting that to noradrenaline. Pretreatment of rats with parachlorophenylalanine (PCPA) abolished the contraction to adenosine (5 X 10(-4) M). Responses to 5-HT and noradrenaline were not significantly affected. These results indicate that the contractile response of the rat tail artery induced by adenosine is probably mediated by endogenous 5-HT.
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013623:Tail / Q000098:blood supply; D014661:Vasoconstriction / Q000187:drug effects*
D012701:Serotonin; D000241:Adenosine; D008784:Methysergide