title: The disposition of 10-10' oxybisphenoxarsine (OBPA) in rats, rabbits and guinea pigs.
abstract: The disposition of 10-10' oxybisphenoxarsine (OBPA), a potent, wide spectrum anti-microbial agent widely used in plastics, was investigated in rats, guinea pigs and rabbits. All animals were given a single dose of [U-14C]OPBA by gavage. Urine and feces were collected daily for 7 days, at which time the animals were sacrificed and tissue samples removed for analysis. In all three species, approximately 90% of the administered dose was excreted within 7 days. The rabbits and guinea pigs excreted about 58% via the feces and 32% via the urine. The rats, however, excreted 82% via the feces and 10% via the urine. There were significant differences in the tissue distribution of radio-activity between the three species. The most prominent difference was that the erythrocytes of the rat retained 3.2% of the administered radiolabel while only 0.08% and 0.03% of the dose remained in the erythrocytes of the guinea pig and rabbit, respectively.
mesh_terms: D000818:Animals; D001152:Arsenicals / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D006168:Guinea Pigs; D008297:Male; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D014018:Tissue Distribution
chemical_list: D001152:Arsenicals; C017617:phenoxarsine oxide