Familial ovarian cancer. How rare is it?
This paper reports an apparently hereditary ovarian carcinoma in the authors' family. A grandmother, her daughter and five granddaughters have been affected. Three of the granddaughters were sisters. The mode of transmission appears to be autosomal dominant, with males capable of being carriers. Present methods of record-keeping make it difficult to link affected females in a family. Further studies are required to find the true incidence of familial ovarian cancer.
D000230:Adenocarcinoma / Q000235:genetics*; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000235:genetics*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics*; D010375:Pedigree