Metabolism in rats of several carboxylic acid derivatives containing the 3,4-methylenedioxyphenyl group.
The metabolism of the 3,4-methylenedioxy derivatives of mandelic acid (1), phenylacetic acid (2), benzoic acid (3), 3-phenylpropionic acid (4) and cinnamic acid (5) was studied in rats. Following intragastric dosage (1 mmol/kg) the compounds and their metabolites were excreted in the urine within 24 hrs. Recoveries of roughly 85% were obtained. Except for compound (1) which was excreted to a large extent unchanged, glycine conjugates were the major urinary metabolites. Compound (2) formed 3,4-methylenedioxyphenylacetylglycine whereas compounds (3), (4) and (5) were converted to 3,4-methylenedioxybenzoylglycine. No evidence was found with any of the compounds for demethylenation and subsequent excretion of catecholic metabolites.
D000818:Animals; D001565:Benzoates / Q000652:urine; D002264:Carboxylic Acids / Q000652:urine*; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D002934:Cinnamates / Q000652:urine; D004149:Dioxoles / Q000652:urine*; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D008333:Mandelic Acids / Q000652:urine; D010648:Phenylacetates / Q000652:urine; D010666:Phenylpropionates / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains
D001565:Benzoates; D002264:Carboxylic Acids; D002934:Cinnamates; D004149:Dioxoles; D008333:Mandelic Acids; D010648:Phenylacetates; D010666:Phenylpropionates