Enhancement and inhibition of phagocytic activity in the retinal pigment epithelium.
The phagocytic activity of the pigmented epithelium of the bovine retina was studied with an organ culture model. Latex particles coated with immunoglobulin, or bovine rod outer segments, both labelled with radioactive iodine, were the objects to be phagocytosed. Various agents were tested with this model for their effects on phagocytosis by the retinal pigment epithelium. Iodoacetate significantly inhibited phagocytosis, as did penicillin, though to a lesser extent. Concanavalin A and gentamicin enhanced phagocytosis. Dimethyl sulfoxide had no effect. The results with lymphokines were not conclusive.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002417:Cattle; D003208:Concanavalin A / Q000494:pharmacology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D006801:Humans; D007461:Iodoacetates / Q000494:pharmacology; D019807:Iodoacetic Acid; D008222:Lymphokines / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects*; D010786:Photoreceptor Cells / Q000276:immunology*; D010857:Pigment Epithelium of Eye / Q000276:immunology*
D000900:Anti-Bacterial Agents; D007461:Iodoacetates; D008222:Lymphokines; D003208:Concanavalin A; D019807:Iodoacetic Acid; D004121:Dimethyl Sulfoxide