[Iodine excess and iatrogenic thyroid pathology (author's transl)].
Iodine-induced thyroid disorder is frequent. Amiodarone is responsible for more than half cases of iodine-induced hypothyroidism and hyperthyroidism. Iodine-induced hypothyroidism is detected by the Perchlorate discharge test where its positivity suggests failure of the normal iodine organification. An inhibition of the thyroglobulin proteolysis is probably involved in the pathological process of iodine-induced hypothyroidism. Premature infants are unusually sensitive to iodine excess. Hypothyroidism has been induced in 50% of newborns of 34 weeks or less of gestation after the application, for a few days, of iodized antiseptics. Iodine-induced thyrotoxicosis account for 6% of patients with hyperthyroidism. It occurs most frequently in male with prior normal thyroid gland. The main diagnosis features are the activation of the 131I uptake by exogenous TSH and the spontaneous evolution towards cure. However, in some cases, the severity of the thyrotoxicosis or the slow spontaneous resolution require surgical or medical therapy. From different therapeutic trials it seems that only corticoids and Propylthiouracile are useful. PTU, believed as the drug of choice, has however an incomplete and inconstant effect. The histochemical aspects of the iodine-induced hypo and hyperthyroidism let suppose the possibility of some common mechanism.
D000328:Adult; D000638:Amiodarone / Q000009:adverse effects; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D007037:Hypothyroidism / Q000175:diagnosis / Q000209:etiology*; D007049:Iatrogenic Disease; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology; D007234:Infant, Premature; D007454:Iodides / Q000009:adverse effects* / Q000378:metabolism; D007457:Iodine Radioisotopes; D008297:Male; D013972:Thyrotropin / Q000494:pharmacology
D007454:Iodides; D007457:Iodine Radioisotopes; D013972:Thyrotropin; D000638:Amiodarone
Surcharge iodée et pathologie thyroïdienne iatrogène.