Atherogenesis. Structure of pathomorphic lipid droplets.
Based on a detailed structural analysis of the lipid droplets from human atherosclerotic lesions, it is proposed that these droplets possess an icosahedral capsid (belonging to T = 3 series) containing globular micelles arranged as dimers along axes of 2-fold symmetry, and as trimers giving rise to hexamer and pentamer clustering along axes of 3-fold and 5-fold symmetry. An attempt is made to specify the molecular organization of lipids leading to the formation of intracellular lipid droplets in the pathogenesis of atherosclerosis.
D000293:Adolescent; D000328:Adult; D001161:Arteriosclerosis / Q000378:metabolism*; D002788:Cholesterol Esters / Q000378:metabolism; D006801:Humans; D008055:Lipids; D008823:Micelles; D008855:Microscopy, Electron, Scanning; D008958:Models, Molecular
D002788:Cholesterol Esters; D008055:Lipids; D008823:Micelles