Decreased cell-mediated immunity to respiratory syncytial virus in multiple sclerosis.
We compared lymphocyte transformation to respiratory syncytial virus in patients with multiple sclerosis (MS) and in healthy controls. Lymphocyte transformation was decreased in MS in the presence or absence of autologous plasma, adding to the evidence that cellular immunity to viral antigens may be broadly impaired in MS, and does not occur uniquely for any single virus.
D000328:Adult; D000956:Antigens, Viral / Q000276:immunology; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D009103:Multiple Sclerosis / Q000276:immunology* / Q000382:microbiology; D012136:Respiratory Syncytial Viruses / Q000276:immunology*
D000956:Antigens, Viral