Effect of bolandiol dipropionate (anabiol), an anabolic hormone, on diethylnitrosamine-induced hepatocarcinogenesis in rat.
The effect of bolandiol dipropionate (Anabiol), an anabolic steroid hormone, on hepatocarcinogenesis was investigated in rats. Anabiol was injected at a dose of 5 mg into the thigh muscle at intervals of 2 weeks, simultaneously with or subsequently to the 4-week administration of diethylnitrosamine (DEN). The average number of tumors larger than 3 mm in diameter per rat in the subsequently treated group at 25 weeks after commencement of DEN was significantly increased and the number of tumors larger than 5 mm in diameter per rat in the simultaneously treated group was significantly increased, when compared with that in the group given DEN alone. Thus, the enhancing effect of Anabiol on hepatocarcinogenesis was evident in terms of tumor size, regardless of whether the hormone was given simultaneously with or subsequently to the carcinogen.
D000818:Animals; D002273:Carcinogens; D004052:Diethylnitrosamine; D004357:Drug Synergism; D004963:Estrenes / Q000494:pharmacology*; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; D004963:Estrenes; D004052:Diethylnitrosamine; C034533:bolandiol dipropionate