Synthesis of L-cysteine derivatives of immunotropic activity.
In continued search for new compounds with immunotropic and anti-inflammatory activity we developed synthesis of the seven following new derivatives of L-cysteine: S-methyl-N-acetylcysteine amide, hydrazide and acetylhydrazide, acetyl derivatives of S-methyl-N-acetylcysteine methylhydrazide, S-methylcysteine morpholineamide and S-methyl-N-acetylcysteine morpholineamide. In general the syntheses consisted in obtaining esters of cysteine and S-methylcysteine, which were submitted to aminolysis and the obtained derivatives were acetylated with acetic anhydride. S-Methylcysteine morpholineamides were obtained by condensation of morpholine with cysteine derivatives by carbodiimied and/or mixed anhydride method. Yields of the compounds were high. Elemental composition was confirmed by elementary analysis.
D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D003545:Cysteine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D007166:Immunosuppressive Agents / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D003545:Cysteine