title: Effects of hemidecortication on the regulation of rat thyroid function.
abstract: 1. Thyroid function in hemidecorticate and control rats was studied by the measurement of oxygen consumption (under basal conditions and after cold exposure) and radioiodine (131 I) uptake by the thyroid after a low-iodine diet for 30 days. 2. The oxygen uptake of male and female hemidecorticate rats under basal conditions (29 degrees C) did not differ significantly from that of the controls. The values observed for both experimental groups were relatively constant, ranging from 40 to 75 kcal h-1 m-2 for 2 to 50-day-old animals. 3. When hemidecorticate and control rats, age 60-65 days, were exposed to 7-8 degrees C for 5-6 h, the oxygen consumption of the hemidecorticate rats increased (83-84 kcal h-1 m-2) but to a lower extent than that of the controls (105-106 kcal h-1 m-2). 4. The rate of radioiodine (131 I) uptake by the thyroid gland of hemidecorticate rats was also lower than that of controls when the animals were maintained on a low-iodine diet. 5. These results show that, under basal conditions, the hypothalamic-pituitary-thyroid axis of hemidecorticate rats does not differ from that of control rats. However, when exposed to cold the hemidecorticate animals were not able to increase their oxygen consumption to the extent achieved by the control groups.
mesh_terms: D000818:Animals; D002541:Cerebral Decortication; D003080:Cold Temperature; D004032:Diet; D005260:Female; D007457:Iodine Radioisotopes; D008297:Male; D009929:Organ Size; D010101:Oxygen Consumption; D051381:Rats; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000473:pathology / Q000502:physiology*; D013965:Thyroidectomy
chemical_list: D007457:Iodine Radioisotopes