Abortion may sensitize the mother to HLA antigens.
The incidence of cytotoxic antibodies in relation to histories of abortions was analyzed in sera from 474 nulliparous pregnant women. In patients with previous spontaneous abortions, there is a higher incidence of positive sera than in primigravidae. Furthermore, patients with two or more prior abortions show a greater incidence of cytotoxic activity in their sera than women who have had only one abortion.
D000022:Abortion, Spontaneous / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007518:Isoantibodies / Q000032:analysis; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013997:Time Factors
D006680:HLA Antigens; D007518:Isoantibodies