Peritoneal absorption of the antibacterial and antiendotoxin taurolin in peritonitis.
1 Taurolin metabolite plasma concentrations were measured in two groups of patient undergoing abdominal surgery, one group with peritonitis and the other without peritonitis, each group receiving taurolin by intraperitoneal instillation. 2 There was no significant difference in the area under the curves, for the two groups, for one of the metabolites. This would suggest that the absorption of taurolin was not modified in inflammatory conditions such as bacterial peritonitis.
D000042:Absorption; D000328:Adult; D000900:Anti-Bacterial Agents / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010537:Peritoneum / Q000378:metabolism*; D010538:Peritonitis / Q000378:metabolism*; D013654:Taurine / Q000031:analogs & derivatives*; D013829:Thiadiazines / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D013843:Thiazines / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D013829:Thiadiazines; D013843:Thiazines; D013654:Taurine; C012566:taurolidine