The effect of sodium salicylate on body temperature in normothermic and febrile rabbits with enhanced level of Cu2+.
Increased level of Cu2+, induced by intravenous injection of CuCl2 at a dose of 2 mg Cu2+/kg in normothermic and Escherichia coli lipopolysaccharide treated rabbits, enhanced the antipyretic effect of sodium salicylate. Furthermore, in the presence of CuCl2, sodium salicylate caused a fall of body temperature in normothermic rabbits.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D003300:Copper / Q000097:blood*; D005260:Female; D005334:Fever / Q000503:physiopathology*; D008297:Male; D011817:Rabbits; D012980:Sodium Salicylate / Q000494:pharmacology*
D003300:Copper; D012980:Sodium Salicylate