The stability of sarin and soman in dilute aqueous solutions and the catalytic effect of acetate ion.
The hydrolysis of aqueous solutions of organophosphonate compounds such as sarin and soman is a critical factor in biochemical and therapeutic studies. The ability to dilute and transport these compounds with assurance of their purity is imperative to the integrity of such studies. An enzymic method has been used to measure low levels of organophosphonates. Maximum stability data were determined in aqueous and isotonic saline solutions. Acetate ion was found to significantly accelerate hydrolysis.1
D000085:Acetates / Q000494:pharmacology*; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D009943:Organophosphorus Compounds; D012524:Sarin; D012996:Solutions; D012999:Soman; D013696:Temperature
D000085:Acetates; D009943:Organophosphorus Compounds; D012996:Solutions; D012999:Soman; D012524:Sarin