Quinidine pharmacokinetics in continuous ambulatory peritoneal dialysis.
The clearance of quinidine was evaluated in a patient undergoing continuous ambulatory peritoneal dialysis (CAPD). The dialysis clearance of quinidine was 0.793 ml/min which represented only 0.61% of the total body clearance (154.21 ml/min) of the drug. The elimination half-life of quinidine was 5.44 hours. Based on our results, dosage adjustment of quinidine does not appear to be necessary for patients undergoing CAPD.
D001145:Arrhythmias, Cardiac / Q000150:complications / Q000188:drug therapy; D005260:Female; D006207:Half-Life; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism / Q000628:therapy; D007700:Kinetics; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011802:Quinidine / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use
D011802:Quinidine