Comparative study on the nuclear DNA content of leiomyoma, leiomyoblastoma and leiomyosarcoma of the stomach and small intestine.
The nuclear DNA content of tumor cells in 5 leiomyomas, 4 leiomyoblastomas and 2 leiomyosarcomas of the stomach and 1 leiomyosarcoma of the small intestine was examined. From the viewpoint of nuclear DNA content, leiomyoblastoma was between leiomyoma and leiomyosarcoma. A definite difference in nuclear DNA content exists among leiomyoma, leiomyoblastoma and leiomyosarcoma, and percentage of nuclei with a DNA content of 3 times or 4 times over the basic chromosome content represented good indices for distinguishing between benign and malignant conditions. A diagnosis of leiomyocarcinoma may be more accurate when over 80% of the nuclei have DNA content values over 3 times of basic nuclear DNA content and when over 50% exhibit more than 4 times of basic content.
D000328:Adult; D000368:Aged; D004273:DNA, Neoplasm / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000032:analysis* / Q000175:diagnosis; D007421:Intestine, Small; D007889:Leiomyoma / Q000032:analysis* / Q000175:diagnosis; D007890:Leiomyosarcoma / Q000032:analysis* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000032:analysis* / Q000175:diagnosis
D004273:DNA, Neoplasm