Bronchodilator effect of tiaramide hydrochloride.
A bioassay with tiaramide hydrochloride (THC) and placebo was performed in 32 non-asthmatic patients suffering from chronic obstructive lung disease. Each patient received one administration of THC (200 mg) and one of placebo according to a double-blind cross-over design. FVC, FEV1, FM25-75, PEF and FEF200-1,200 were measured before and at several intervals until 360 min after treatment. Significant differences were found between drug and placebo which gave no significant variations. It is concluded that THC is an effective and safe bronchodilator. The substained bronchodilator effect shown by THC appears to be a clinical advantage.
D000328:Adult; D000368:Aged; D052160:Benzothiazoles; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D012129:Respiratory Function Tests; D013844:Thiazoles / Q000627:therapeutic use*
D052160:Benzothiazoles; D001993:Bronchodilator Agents; D010879:Piperazines; D013844:Thiazoles; C003468:tiaramide