Gas-liquid chromatographic determination of mexiletine in human serum with nitrogen sensitive detection.
A simple and rapid method for the quantitative determination of mexiletine, using gas-liquid chromatography with nitrogen sensitive detection, is described. Only one extraction step is needed, the recovery is between 92-96% and the precision varies between 2.0--5.5%. The lower limit of detection reached 0.5 micro mol/1. During routine handling the method was easy, quick and cheap.
D002849:Chromatography, Gas / Q000379:methods; D006801:Humans; D008801:Mexiletine / Q000097:blood*; D008832:Microchemistry; D011437:Propylamines / Q000097:blood*
D011437:Propylamines; D008801:Mexiletine