Role of lymphocytes in non-immune experimental inflammation.
The role of lymphocytes in acute, non-immune inflammation has been studied in rats. Using drug-induced leucopenia and cell transfer studies it was found that the reduced carrageenin paw oedema in leucopenic rats could be restored by a specific subclass of lymphocytes distinct from T and B lymphocytes. The inflammatory effect of these lymphocytes appears to be mediated by a factor, the release of which is inhibited by steroidal and non-steroidal anti-inflammatory drugs and antilymphocyte sera.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002478:Cells, Cultured; D007249:Inflammation / Q000503:physiopathology*; D007970:Leukopenia / Q000503:physiopathology; D008214:Lymphocytes / Q000276:immunology / Q000502:physiology*; D051381:Rats; D014181:Transplantation Immunology; D014185:Transplantation, Isogeneic
D000893:Anti-Inflammatory Agents