Chromatographic purification from Streptococcus faecium extract of a factor active on Picornaviridae.
"In vitro" antiviral activity against Picornaviridae and the trials for purification from Str. faecium extract of a factor responsible of these effects are reported. Fractionation on Bio-Gel P-150 and on DEAE-cellulose column and analytical methods for protein and aminosugars were used. Present results demonstrate an antiviral activity of Str. faecium extract against Picornaviridae. Virus inhibiting activity is not correlated with the majority of the Folin reacting proteins, which are present in the bacterial extract. No reliable relationship could be detected for aminosugars containing components, since the amount of aminosugar in fraction from Bio-Gel is extremely low and widely distributed.
D000998:Antiviral Agents / Q000302:isolation & purification*; D002478:Cells, Cultured; D002850:Chromatography, Gel; D006801:Humans; D010849:Picornaviridae / Q000187:drug effects*; D013291:Streptococcus / Q000032:analysis*
D000998:Antiviral Agents