[Effect of conalbumin on stimulation by phytomitogens and on rosette E formation of human peripheral lymphocytes of normal subject].
We carried on an immunological in vitro study on conalbumin, an iron binding protein structurally similar to lactoferrin, a well know bacterial inhibitor of human milk. Conalbumin itself has been proved to have bacteriostatic activity against a broad spectrum of bacteria responsible for gastrointestinal infections. The activity of conalbumin on the in vitro response to PHA, PWM and Con A and on the E-rosette formation ability and does not induce blastic transformation of lymphocytes. However, conalbumin has been able to significantly increase the in vitro response of lymphocytes to PHA and PWM, suggesting an action on both T and B lymphocytes.
D000328:Adult; D003207:Conalbumin / Q000494:pharmacology*; D004527:Egg Proteins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D037102:Lectins / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011043:Pokeweed Mitogens / Q000494:pharmacology*; D012397:Rosette Formation
D004527:Egg Proteins; D037102:Lectins; D011043:Pokeweed Mitogens; D003207:Conalbumin
Effectto della conalbumina sulla stimolazione da fitomitogeni e sulla formazione delle rosette-E di linfociti periferici umani di soggetti normali.