[Effect of remantadine on the development of toxicoses caused by different strains of influenza virus].
The effect of remantadine on the development of viral toxicosis caused in mice by original and remantadine-resistant strains of influenza virus was studied. A definite reduction of the antitoxic effectiveness of remantadine was demonstrated in passages of toxigenic influenza A virus strain in its presence. Prophylactic administration of remantadine protected mice from the development of toxic pulmonary edema and death caused by inoculation of a massive dose of influenza B virus. Passages of influenza B virus in the presence of remantadine produced a strain causing toxicosis in mice the course of which was not affected by remantadine any longer.
D000218:Adamantane / Q000031:analogs & derivatives*; D000818:Animals; D004352:Drug Resistance, Microbial; D009980:Influenza A virus / Q000187:drug effects; D051379:Mice; D009975:Orthomyxoviridae / Q000187:drug effects; D009976:Orthomyxoviridae Infections / Q000150:complications / Q000188:drug therapy*; D012299:Rimantadine / Q000494:pharmacology / Q000627:therapeutic use*; D013045:Species Specificity; D014115:Toxemia / Q000188:drug therapy*
D012299:Rimantadine; D000218:Adamantane
Vliianie remantadina na razvitie toksikoza, vyzvannogo razlichnymi shtammami virusa grippa.