The choleretic action of clanobutin in dogs.
After cannulation of the bile duct in anaesthetised dogs, clanobutin was injected intravenously. Samples were collected for periods of 15 min. Arterial and venous blood pressures as well as the electrocardiogram were recorded during the experiment. There was a slight increase in arterial and central venous pressure during the trial. Heart rate slightly decreased with a slight increase in ventricular ectopic beats. In the first 15 min after bile flow increased by 260%. The choleretic action lasted for 1,5 h. The concentration of sodium, potassium and magnesium in the bile followed a similar pattern to that of the volume. Bilirubin and calcium excretion showed a sharp increase within the first 15 min after administration. Thereafter there was a sharp drop and 30 min after administration the concentration was below the control value.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001663:Bilirubin / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002756:Cholagogues and Choleretics / Q000494:pharmacology*; D004285:Dogs / Q000378:metabolism*; D005260:Female; D008274:Magnesium / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D002756:Cholagogues and Choleretics; D005680:gamma-Aminobutyric Acid; D012964:Sodium; D008274:Magnesium; D001663:Bilirubin; D011188:Potassium; D002118:Calcium; C019159:clanobutin