title: [Combined action of remantadine (amantadine) and ribavirin on experimental influenza].
abstract: The inhibiting effect of remantadine (amantadine) and ribavirin combination on experimental influenza infection was studied in comparison of the effect of each of these drugs alone. The combination of the two chemopreparations was found to inhibit synthesis of influenza A virus proteins in cell culture more effectively, to ensure maximum survival rate of white mice treated with these preparations by oral, aerosol and intraperitoneal routes of administration.
mesh_terms: D000284:Administration, Oral; D000336:Aerosols; D000547:Amantadine / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D002642:Chick Embryo; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D066298:In Vitro Techniques; D007391:International Cooperation; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D012254:Ribavirin / Q000008:administration & dosage / Q000627:therapeutic use*; D012263:Ribonucleosides / Q000627:therapeutic use*; D013781:Texas; D014586:USSR
chemical_list: D000336:Aerosols; D012263:Ribonucleosides; D012254:Ribavirin; D000547:Amantadine
vernacular_title: Izuchenie kombinirovannogo deĭstviia remantadina (amantadina) i ribavirina na éksperimental'nuiu grippoznuiu infektsiiu.