title: [Periodic arthralgia: teratogenicity of colchicine and its influence on pregnancy and sterility (author's transl)].
abstract: Pregnancy appears to exert a beneficial effect on periodic arthralgia, the frequency of episodes being reduced by a half. Sterility, probably of anavulatory rather than mechanical origin, occurs in one third of cases. Its frequency could be diminished by colchicine, which by its anti-inflammatory action can prevent the development of mechanical sequelae. Though colchicine appears to lack teratogenetic activity, it should be discontinued three months before pregnancy.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003078:Colchicine / Q000009:adverse effects*; D010505:Familial Mediterranean Fever / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000150:complications* / Q000628:therapy; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D013723:Teratogens
chemical_list: D013723:Teratogens; D003078:Colchicine
vernacular_title: Grossesse et stérilité au cours de la maladie périodique. Influence de la colchicine. Appréciation de son effet tératogène.