Isolation of geodiastatins 1 and 2 from the marine sponge Geodia mesotriaena.
An aqueous extract of the Gulf of California Geodia mesotriaena von Lendenfeld (Porifera) has been found to contain two chromoprotein antineoplastic agents designated geodiastatins 1 and 2. The active brownish-black proteins from this siliceous sponge were found to contain major (greater than 1%) amounts of silicon and to inhibit growth of the murine P388 lymphocytic leukemia. A related protein (geodiatoxin 1) was found to be toxic at 6 mg/kg (LI100, mouse).
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D007928:Lethal Dose 50; D007941:Leukemia P388 / Q000188:drug therapy; D008164:Luminescent Proteins / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D051379:Mice; D011161:Porifera / Q000032:analysis*
D000970:Antineoplastic Agents; D008164:Luminescent Proteins; C033272:geodiastatins