Experimental corticosteroid myopathy.
The steroids triamcinolone, dexamethasone, beta-methasone, and cortisone were administered i.p. to adult rats for 14-63 days. The extensor digitorum longus (EDL, white muscle) and soleus (SOL, red muscle) muscles were examined histologically and histochemically. Triamcinolone was the most potent lesion-producing drug. Selective involvement of muscles, and of the fiber types within them was observed: Necrotic changes were seen only in the type 1 fibers of the SOL; atrophic fibers were observed in the type 2 fibers of both the SOL and the EDL.
D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000818:Animals; D001623:Betamethasone / Q000009:adverse effects / Q000031:analogs & derivatives; D003348:Cortisone / Q000009:adverse effects; D003907:Dexamethasone / Q000009:adverse effects; D008297:Male; D009132:Muscles / Q000473:pathology*; D009133:Muscular Atrophy / Q000139:chemically induced* / Q000473:pathology; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains; D014221:Triamcinolone / Q000009:adverse effects
D000305:Adrenal Cortex Hormones; D014221:Triamcinolone; C028994:betamethasone sodium phosphate; D003907:Dexamethasone; D001623:Betamethasone; D003348:Cortisone