title: Single oral-dose metronidazole therapy for trichomonas vaginitis in adolescents.
abstract: A group of 218 adolescent girls in a detention setting was treated for vaginal trichomoniasis with a single 2-g oral dose of metronidazole, a successful therapeutic approach in infected adults. This method of treatment has not been reported in teenagers. The initial diagnosis and posttreatment test for cure were based on a Gram stain of vaginal secretions. Administration of the medication and avoidance of reinfection were controlled. The test for cure was done 5 days after treatment. The cure rate under these conditions was 98%. Side effects were infrequent and minor. Our results suggest that single-dose therapy not only avoids the problem of patient compliance but is effective, safe, and less costly than a standard 7- or 10- day regimen.
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage*; D014247:Trichomonas Vaginitis / Q000188:drug therapy*
chemical_list: D008795:Metronidazole