title: [Effect of histidine analogs and histidyl-containing dipeptides on the decarboxylase activity of Micrococcus sp. n. histidine decarboxylase].
abstract: L-Histidinol and L-histidine hydroxamate were shown to inhibit competitively histidine decarboxylase from Micrococcus sp. n responsible for histamine biosynthesis. Constants of their inhibitory effect were found. Histidyl-containing dipeptides did not exhibit the pronounced inhibitory effect. The rate of inhibition was increased after esterification of histidyl dipeptide. Kinetics of the histidine decarboxylase inhibition by L-histidyl-L-leucine methyl ester was studied.
mesh_terms: D002262:Carboxy-Lyases / Q000378:metabolism*; D003653:Decarboxylation; D004151:Dipeptides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006639:Histidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006640:Histidine Decarboxylase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007700:Kinetics; D008837:Micrococcus / Q000187:drug effects* / Q000201:enzymology
chemical_list: D004151:Dipeptides; D006639:Histidine; D002262:Carboxy-Lyases; D006640:Histidine Decarboxylase
vernacular_title: Vliianie analogov gistidina i gistidilsoderzhashchikh dipeptidov na dekarboksilaznuiu aktivnost' gistidinekarboksilazy Micrococcus sp. n.