[Analysis of middle molecules in the cerebrospinal fluid of uremic patients].
The pathogenesis of the uraemic polyneuro-encephalopathy is unclear. Among the many possible factors also accumulations of certain medium molecule fractions of peptides and disturbances of the tryptophan metabolism shall play a role. Of 8 deceased conservatively treated uraemics and 4 patients of the chronic haemodialysis programme with a dementia of dialysis serum and postmortally got cerebrospinal liquor underwent a medium molecule fractioning. While in the liquor of normal persons no medium molecules could be proved, these substances were found in the liquor of uraemics in a nearly serum-identical pattern with clearly reduced concentrations. First of all their provenience by a toxically injured blood liquor barrier is to be explained. In contrast to the control values only conservatively treated uraemics showed significantly increased tryptophan concentrations in the liquor. However, the tryptophan concentrations of the patients with dementia were within the normal area.
D000328:Adult; D001812:Blood-Brain Barrier; D003704:Dementia / Q000134:cerebrospinal fluid / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects; D014118:Toxins, Biological / Q000134:cerebrospinal fluid*; D014364:Tryptophan / Q000134:cerebrospinal fluid; D014511:Uremia / Q000134:cerebrospinal fluid*
D014118:Toxins, Biological; C026865:uremia middle molecule toxins; D014364:Tryptophan
Mittelmolekülanalysen im Liquor von Urämikern.