title: Studies of chromophores in model membranes by polarized light-absorption spectroscopy. The orientation and binding of tetracaine and procaine.
abstract: A method for studying the orientation and binding of chromophores in macroscopically aligned membranes by polarized light absorption spectroscopy is described. Here tetracaine and procaine solubilized in a lamellar phase of octanoyl-1-glyceride (monooctanoin) and water have been investigated. Tetracaine is found to be located in the lipid region with a preferential orientation of the molecular long axis parallel to the hydrocarbon chains. The orientation of procaine, mainly residing in the water region, is very small.
mesh_terms: D001665:Binding Sites; D008566:Membranes / Q000032:analysis*; D008958:Models, Molecular; D011343:Procaine / Q000032:analysis*; D013053:Spectrophotometry / Q000379:methods; D013748:Tetracaine / Q000032:analysis*
chemical_list: D013748:Tetracaine; D011343:Procaine