Biochemical and estrogenic activity of some diethylstilbestrol metabolites and analogs in the mouse uterus.
DES is metabolized to a number of compounds through a minimum of three main metabolic routes. These routes result in some inactivity of DES as an estrogen, but the majority appear to produce estrogenic by-products, which in some cases produce divergent in vivo and in vitro hormone activities. Therefore, if DES undergoes this type of metabolism, then large doses or repeated ingestion could produce a body burden of compounds with a wide range of hormonal activities possessing some possibly toxic or carcinogenic nature. It is apparent that these types of findings must also be considered when DES is used as an estrogenic test substance. The studies in this report have only attempted to ascertain the hormonal activity or these compounds and do not address the questions of their toxic or carcinogenic nature.
D000818:Animals; D001667:Binding, Competitive; D001711:Biotransformation; D004247:DNA / Q000096:biosynthesis; D004054:Diethylstilbestrol / Q000378:metabolism* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000378:metabolism; D004967:Estrogens / Q000633:toxicity*; D005260:Female; D051379:Mice; D011960:Receptors, Estrogen / Q000187:drug effects / Q000378:metabolism; D011980:Receptors, Progesterone / Q000187:drug effects; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism
D004967:Estrogens; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D004958:Estradiol; D004054:Diethylstilbestrol; D004247:DNA