title: Alcoholism, nonprescription drug and hepatotoxicity. The risk from unknown acetaminophen ingestion.
abstract: An alcoholic patient developed severe hepatitis and renal failure after ingesting the contents of a 300 ml. bottle of Nyquil for its ethanol content. This illness was presumably related to the 6 gm. of acetaminophen contained in this nonprescription preparation. Although hepatic damage with or without renal failure is usually described after a massive overdose of acetaminophen, the changes in drug metabolism induced by chronic ethanol consumption may increase the risk for acetaminophen toxicity. The large number of nonprescription acetaminophen-ethanol preparations available should be considered in evaluating an alcoholic patient seen with acute hepatic and renal dysfunction.
mesh_terms: D000082:Acetaminophen / Q000378:metabolism / Q000506:poisoning*; D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D000437:Alcoholism / Q000150:complications*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism; D004366:Nonprescription Drugs
chemical_list: D004366:Nonprescription Drugs; D000082:Acetaminophen