Glomerular podocyte cell junctions in nephrotic syndrome. II. Freeze-fracture studies in human nephrotic syndrome.
In six patients with nephrotic syndrome and in two control subjects freeze-fracture studies of isolated glomeruli obtained by needle biopsies were performed. In the nephrotic patients replicas of freeze-fractured podocytes showed an increased number of cell junctions. These were represented by incomplete occluding junctions and communicating junctions (gap junctions). There was morphologically a similarity between the glomerular podocyte cell junctions in human and experimental nephrotic syndrome (Kühn et al., 1981).
D000293:Adolescent; D000328:Adult; D002196:Capillaries / Q000648:ultrastructure; D002648:Child; D005614:Freeze Fracturing; D006801:Humans; D007365:Intercellular Junctions / Q000648:ultrastructure*; D007678:Kidney Glomerulus / Q000098:blood supply / Q000648:ultrastructure*; D009404:Nephrotic Syndrome / Q000473:pathology*