The carcinogenic effect of 1,1-diethyl-3-methyl-3-nitrosourea in European hamsters.
Laboratory-bred European hamsters received subcutaneous injections of 1,1-diethyl-3-methyl-3-nitrosourea once weekly for life. The animals developed mainly squamous cell carcinomas of the nasal and oral cavities and malignant sarcomas (schwannomas) of the glandular stomach. The average tumour latency was shorter in females (24 weeks) than in males (28 weeks), while tumour incidence was 80% for both sexes.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D006224:Cricetinae; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009607:Nitrosourea Compounds / Q000633:toxicity*
D002273:Carcinogens; D009607:Nitrosourea Compounds; C026466:diethylmethylnitrosourea