Splanchnic turn-over of some energy metabolites and acid-base balance during intravenous infusion of lidocaine, bupivacaine or etidocaine.
The splanchnic turn-over of energy metabolites in circulating blood has been studied in four groups of young, healthy volunteers, receiving intravenous infusions of physiological saline (n = 5), lidocaine 4 mg/min (n = 7), bupivacaine 2 mg/min (n = 7) and etidocaine 2 mg/min (n = 8). The results showed that the local anaesthetic agents increased the splanchnic blood flow and oxygen consumption, the uptake of glycerol and lactate, and the release of 3-hydroxybutyrate. These effects are adrenaline-like but cannot be explained by one single mechanism involving increased activity of the sympathetic nervous system. Only a minor part of the increased oxygen uptake could be attributed to the energy cost of drug metabolism.
D020155:3-Hydroxybutyric Acid; D000083:Acetanilides / Q000494:pharmacology*; D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002045:Bupivacaine / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D005041:Etidocaine / Q000494:pharmacology*; D005260:Female; D005990:Glycerol / Q000378:metabolism; D006801:Humans; D006885:Hydroxybutyrates / Q000378:metabolism; D007263:Infusions, Parenteral; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D013152:Splanchnic Circulation / Q000187:drug effects*; D013564:Sympathetic Nervous System / Q000187:drug effects
D000083:Acetanilides; D001786:Blood Glucose; D006885:Hydroxybutyrates; D007773:Lactates; D019344:Lactic Acid; D008012:Lidocaine; D005041:Etidocaine; D005990:Glycerol; D020155:3-Hydroxybutyric Acid; D002045:Bupivacaine