title: [Therapy of detrusor hyperactivity with propiverin (mictonorm)].
abstract: In the context of treating hyperactivity of the detrusor the newly developed preparation Propiverin (Mictonorm) is presented. It is postganglionic and anticholinergic and mainly acts peripherally and selectively on the bladder. At the same time a musculotropic relaxing effect with a specific affinity to the unstriated musculature of the bladder can be demonstrated in experiments on animals. In our urodynamic investigations the application of the medicament resulted in an increase in bladder capacity, a reduction of urge symptoms, a decrease in bladder tension and a depression of the uroflow. These results justify the clinical use of Propiverin after appropriate urodynamic diagnostic checks.
mesh_terms: D001561:Benzilates / Q000627:therapeutic use*; D006801:Humans; D006874:Hydrostatic Pressure; D008365:Manometry; D009119:Muscle Contraction / Q000187:drug effects; D010276:Parasympatholytics / Q000627:therapeutic use*; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy*
chemical_list: D001561:Benzilates; D010276:Parasympatholytics; C015586:propiverine
vernacular_title: Zur Therapie der Detrusorhyperaktivität mit Propiverin (Mictonorm).