[Biosynthesis of glycoconjugates in the arterial wall. The role of derivatives of isoprenic pathways and of complex lipids in the glycolization of macromolecules of the intima media].
Previous investigation have shown the occurrence of glycosyl-transferases in the intima-media cells of aortic wall. Some of these enzymes have been isolated from cell-sap as xylosyl-transferase and galactosyl-transferase involved in glycoproteins and glycosamino-glycurono-glycans biosynthesis. Others are located in microsomal fraction as mannosyl-transferase which catalysed polyprenic glycoconjugates biosynthesis. Study of linear and cyclic isoprenic compounds such as squalene and cholesterol, lipidic compounds as sphingolipids and glycerophospholipids and shows their important role as effectors in glycoconjugates biosynthesis regulation; while none of them are intermediates in glycosylation reaction. These lipidic effectors have no effect on substrate-stability nor on ionic reactional parameters. At the opposite, they seem to act in a similar way as non ionic detergents.
D000818:Animals; D001011:Aorta / Q000032:analysis / Q000201:enzymology*; D002417:Cattle; D002850:Chromatography, Gel; D006017:Glycolipids / Q000096:biosynthesis; D006023:Glycoproteins / Q000096:biosynthesis*; D050356:Lipid Metabolism; D046911:Macromolecular Substances; D014166:Transferases / Q000096:biosynthesis*
D006017:Glycolipids; D006023:Glycoproteins; D046911:Macromolecular Substances; D014166:Transferases
Biosynthèse des glycoconjugués dans la paroi artérielle. Etude du rôle des dérivés de la voie isoprénique et des lipides complexes dans la glycosylation des macromolécules de l'intima-media.