The use of acebutolol with hydrochlorothiazide in hypertension.
The antihypertensive effect of acebutolol 400 mg and hydrochlorothiazide 25 mg in combination have been assessed in 22 patients with mild, moderate and severe hypertension. In the supine position, blood pressure went down from an average of 190/116 mm Hg to 147/91 mm Hg after treatment, while in the standing position, blood pressure went down from an average of 188/117 mm Hg to 143/94 mm Hg. Age, sex and duration of hypertension have no significant influence upon the antihypertensive effect of this combination. Good results were obtained in 68% of the patients, fair results in 23% and poor results in another 9%. Compared with the use of acebutolol alone, its combination with hydrochlorothiazide showed better results. In mild hypertension good results increased from 75% after acebutolol only to 100% after this combination. In moderate hypertension the percentage of good results increases from 47% to 60% and in severe hypertension good results increased from 50% to 67%. Increase of decrease in heart rate had no relation to the antihypertensive effect of this combination.
D000070:Acebutolol / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage*; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
D000959:Antihypertensive Agents; D006852:Hydrochlorothiazide; D000070:Acebutolol