title: Saline cathartics and saline cathartics plus activated charcoal as antidotal treatments.
abstract: The results of this experimental study indicate that Na2SO4 reduces the gastrointestinal absorption of aspirin, but not that of pentobarbital, chlorpheniramine, or chloroquine. Activated charcoal (AC) and the combination of AC + Na2SO4 were effective in reducing gastrointestinal absorption of all four test drugs. The combination treatment was more effective than AC treatment in reducing gastrointestinal absorption of aspirin, pentobarbital, and chloroquine. We believe that saline cathartics should not be used in lieu of AC for treatment of poison ingestions, and their routine use to treat poison ingestion should be reevaluated. On the other hand, saline cathartics may be used in conjunction with AC to enhance the antidotal effect of the adsorbent.
mesh_terms: D000818:Animals; D000931:Antidotes; D001241:Aspirin / Q000506:poisoning; D002400:Cathartics / Q000494:pharmacology*; D002606:Charcoal / Q000494:pharmacology*; D002738:Chloroquine / Q000506:poisoning; D002744:Chlorpheniramine / Q000506:poisoning; D005260:Female; D010424:Pentobarbital / Q000506:poisoning; D051381:Rats; D012964:Sodium / Q000494:pharmacology; D013431:Sulfates / Q000494:pharmacology*
chemical_list: D000931:Antidotes; D002400:Cathartics; D013431:Sulfates; C012036:sodium sulfate; D002606:Charcoal; D002744:Chlorpheniramine; D002738:Chloroquine; D012964:Sodium; D010424:Pentobarbital; D001241:Aspirin