A dental approach to carrier screening in X linked hypohidrotic ectodermal dysplasia.
The frequency of carriers of X linked hypohidrotic ectodermal dysplasia among females with hypodontia of the permanent dentition (excluding third molars) could be as high as 1 in 500, and among females with deciduous hypodontia could be as high as 1 in 50. Since it may be possible to identify carriers form among female hypodontia cases in general by virtue of a reduced sweat pore count, the potential exists for a reasonably practical method of screening for carriers at the population level.
D000848:Anodontia / Q000175:diagnosis*; D002648:Child; D003937:Diagnosis, Differential; D004476:Ectodermal Dysplasia / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D006580:Genetic Carrier Screening / Q000379:methods; D008040:Genetic Linkage; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D007007:Hypohidrosis / Q000175:diagnosis; D014960:X Chromosome