[Experimental examination of skeletal muscle perfusion with stroma-free hemoglobin solution in ischemia].
An experimental study about post-ischemic perfusion of muscles with a new stroma-free hemoglobin solution is presented. Compared to other storage and perfusion methods the solution has several advantages: 1. Oxygenation and metabolism of the skeletal muscles are preserved. 2. Excellent wash-out effect. 3. The rheologic characteristics are better than those of whole blood. 4. No incompatibility. 5. No thrombogenetic effect. 6. The method is easy to manage. Our ultrastructural investigations show less damage of the muscle cells after a post-ischemic perfusion with oxygenated hemoglobin solution than after a post-ischemic physiological perfusion with whole blood.
D000818:Animals; D004734:Energy Metabolism; D006454:Hemoglobins / Q000008:administration & dosage*; D006614:Hindlimb / Q000098:blood supply; D007511:Ischemia / Q000517:prevention & control*; D008297:Male; D009115:Muridae; D009132:Muscles / Q000098:blood supply*; D010100:Oxygen / Q000097:blood; D010477:Perfusion; D010952:Plasma Substitutes / Q000008:administration & dosage*
D006454:Hemoglobins; D010952:Plasma Substitutes; C016484:hemoglobin, stroma free; D010100:Oxygen
Experimentelle Untersuchung zur Skelettmuskelperfusion mit stroma-freier Hämoglobinlösung unter Ischämiebedingungen.