Effect of clebopride on lower esophageal sphincter pressure.
In 12 individuals without gastrointestinal symptoms, the IV administration of metoclopramide and of clebopride produced both a significant increase on the lower esophageal sphincter pressure. The increase induced by clebopride was significantly higher than that induced by metoclopramide. The tolerability of clebopride was satisfactory with just mild drowsiness being noted in most cases.
D000293:Adolescent; D000328:Adult; D001549:Benzamides / Q000494:pharmacology*; D004311:Double-Blind Method; D004943:Esophagogastric Junction / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008787:Metoclopramide / Q000494:pharmacology*; D008875:Middle Aged; D011312:Pressure
D001549:Benzamides; C014417:clebopride; D008787:Metoclopramide