title: CEA positivity in tissue and sera of patients with benign breast lesions.
abstract: The presence of CEA was studied in paraffin sections of 100 benign breast lesions using an immunoperoxidase technique. In fibroadenomas, CEA was found in 25% of cases as opposed to 64% with cystic disease with or without epitheliosis. Our results demonstrate a tendency for an increased frequency of CEA tissue positivity in association with a more prominent form of epithelial hyperplasia with cystic disease. The observed higher positivity of tissue CEA may reflect a higher 'cellular activity' in the latter lesions compared with fibroadenomas.
mesh_terms: D000232:Adenofibroma / Q000032:analysis; D000328:Adult; D001940:Breast / Q000032:analysis*; D001943:Breast Neoplasms / Q000032:analysis* / Q000473:pathology; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D002455:Cell Division; D005260:Female; D005348:Fibrocystic Breast Disease / Q000032:analysis; D006801:Humans
chemical_list: D002272:Carcinoembryonic Antigen