Influence of administration route on drug delivery to a target organ.
Mathematical relationships describing the delivery of drug to a target organ after intra-arterial, intravenous, and oral administration are presented. This discussion clearly demonstrates that administration into a blood vessel leading to the target organ often is superior to intravenous administration. However, this superiority is not clear from traditional plasma concentration monitoring data.
D000284:Administration, Oral; D006801:Humans; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D007700:Kinetics; D008954:Models, Biological; D009928:Organ Specificity; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*
D004364:Pharmaceutical Preparations