Harman and norharman: induction of sister-chromatid exchanges in human peripheral lymphocytes in vitro and interaction with isolated DNA.
Harman, but not norharman, induced sister-chromatid exchanges in human peripheral lymphocytes in vitro. Transcription of isolated DNA in vitro was inhibited by both compounds, harman being more effective than norharman. A filter-binding assay with isolated DNA showed that harman binds more effectively to the DNA than norharman.
D000470:Alkaloids / Q000494:pharmacology*; D002243:Carbolines; D002869:Chromosome Aberrations; D003434:Crossing Over, Genetic / Q000187:drug effects*; D004247:DNA / Q000235:genetics*; D006247:Harmine / Q000031:analogs & derivatives / Q000494:pharmacology*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology*; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic / Q000187:drug effects; D014228:Triaziquone / Q000494:pharmacology
D000470:Alkaloids; D002243:Carbolines; D006247:Harmine; C005010:harman; D004247:DNA; C010262:norharman; D014228:Triaziquone