title: Alkylating properties of dichlorvos (DDVP).
abstract: Dichlorvos (DDVP) is a methylating agent. In DNA from mice given 1.9 x 10(-6) mol/kg of DDVP, a degree of alkylation of guanine-N-7 amounting to 8 x 10(-13) mol methyl per g DNA, was found. From this, a rate of clearance of 29 hr-1 was estimated. This value is in reasonable agreement with the value (55 hr-1), calculated from published data on the concentration over time of DDVP in the brain after injection of the compound in mice. Applying a risk estimation on humans exposed to DDVP, the genetic risk connected with the methylating activity of DDVP is low or very low. Comparing the mutagenic effectiveness of DDVP with that of methyl methanesulfonate, indicates that DDVP is more effective than expected from reaction kinetic data. The possible contribution of the dichloroacetaldehyde formed in vivo from DDVP has to be evaluated before a complete risk estimate can be made for DDVP.
mesh_terms: D000477:Alkylating Agents; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004247:DNA / Q000378:metabolism; D004006:Dichlorvos / Q000494:pharmacology* / Q000633:toxicity; D006147:Guanine / Q000378:metabolism; D007700:Kinetics; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D009153:Mutagens; D012306:Risk
chemical_list: D000477:Alkylating Agents; D000596:Amino Acids; D009153:Mutagens; D006147:Guanine; D004006:Dichlorvos; D004247:DNA