Predilection of experimental arterial aneurysms for dietary-induced lipid deposition.
In 14 stock rabbits experimental aneurysms (saccular, fusiform or berry) were produced on the common carotid artery or the aorta by microvascular surgery using a modification of the venous pouch technique. The animals were given a cholesterol-rich diet at varying times postoperatively to determine the susceptibility of the experimental aneurysmal walls to dietary-induced lipid deposition. The experimental aneurysms all exhibited a pronounced predilection for dietary-induced lipid deposition, greater than that of the host artery or the contralateral vein. The results demonstrate the importance of haemodynamic stress in the localization of dietary induced lipid deposition.
D000818:Animals; D001011:Aorta / Q000473:pathology; D001014:Aortic Aneurysm / Q000378:metabolism* / Q000473:pathology; D002339:Carotid Arteries / Q000473:pathology; D002791:Cholesterol, Dietary / Q000378:metabolism; D004041:Dietary Fats / Q000378:metabolism*; D006439:Hemodynamics; D002532:Intracranial Aneurysm / Q000378:metabolism* / Q000473:pathology; D007601:Jugular Veins / Q000473:pathology; D050356:Lipid Metabolism; D011817:Rabbits; D013997:Time Factors
D002791:Cholesterol, Dietary; D004041:Dietary Fats