Significance of 17-hydroxycorticosteroid glucuronide in urine as an index of salicylamide glucuronidation in guinea pigs.
The glucuronidation of 17-hydroxycorticosteroids (17-OHCS) and its effectiveness as an index of salicylamide (SAM) glucuronidation were examined in guinea pigs, the same cortisol type animals as man, treated with carbon tetrachloride (CCl4), D-galactosamine, phenobarbital, D,L-ethionine and alloxan. There was not a statistically significant correlation between the plasma clearance of SAM glucuronidation (CLglu) and the urinary excretion ratio of 17-OHCS glucuronide to total 17-OHCS in the intact, and CCl4, D-galactosamine, alloxan and D,L-ethionine treated guinea pigs (r = 0.158). However, there was a statistically significant correlation between the CLglu and the clearance of 17-OHCS glucuronidation obtained as urinary 17-OHCS glucuronide/plasma cortisol concentration (r = 0.738, p less than 0.1). It was proposed that the clearance of 17-OHCS glucuronide metabolized from endogenous cortisol could be used as an index to assess the drug glucuronidation activity.
D015065:17-Hydroxycorticosteroids / Q000652:urine*; D000496:Alloxan / Q000494:pharmacology; D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology; D005001:Ethionine / Q000494:pharmacology; D005688:Galactosamine / Q000494:pharmacology; D005965:Glucuronates / Q000378:metabolism / Q000652:urine; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000652:urine; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D012457:Salicylamides / Q000378:metabolism*
D015065:17-Hydroxycorticosteroids; D005965:Glucuronates; D012457:Salicylamides; D000496:Alloxan; D005688:Galactosamine; D002251:Carbon Tetrachloride; D006854:Hydrocortisone; D005001:Ethionine; D010634:Phenobarbital