title: Pharmacokinetics of theophylline in swine: a potential model for human drug bioavailability studies.
abstract: The pharmacokinetics of theophylline in swine were investigated following the oral and intravascular administration of single doses of theophylline free base. The mean half-life of theophylline following intravascular administration was 11.0 h, and the apparent specific volume of distribution was 0.61 liter/kg. Following oral administration, theophylline in solution was absorbed quite rapidly with a bioavailability of 79%. The similarity of the pharmacokinetics of theophylline in swine and humans suggests that swine may provide a useful model for the study of the bioequivalency of theophylline dosage forms intended for human use. The pharmacokinetic characteristics of theophylline also favor its consideration for usage as a therapeutic agent in swine.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D005260:Female; D007275:Injections, Intravenous; D007700:Kinetics; D008954:Models, Biological; D013552:Swine / Q000097:blood*; D013806:Theophylline / Q000097:blood*
chemical_list: D013806:Theophylline