[Effectiveness of different alpha-tocopherol derivatives in preventing experimental muscular dystrophy in chickens].
Activity of vitamin E and its derivatives--alpha-tocopheryl quinone, its short chain analogue and alpha-tocopheryl acetate also containing short chain molecule were studied during chicken experimental muscular dystrophy. alpha-Tocopheryl quinone containing short chain molecule proved to be the most active substance; similarly to vitamin E the preparation increased the erythrocyte resistance to osmotic haemolysis, distinctly increased the content of ubiquinone and decreased concentration of ubichromenol in the chicken liver tissue as compared with E-deficient animals. At the same time, the content of ubiquinone was unaltered in skeletal muscles. The data obtained suggest that vitamin E could be effectively substituted by its derivatives for prevention an treatment of muscular dystrophy.
D000818:Animals; D002645:Chickens; D004353:Drug Evaluation, Preclinical; D009137:Muscular Dystrophy, Animal / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D014811:Vitamin E Deficiency / Q000150:complications; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D014810:Vitamin E; C002421:tocopherylquinone; D024502:alpha-Tocopherol; D024505:Tocopherols
Izuchenie éffektivnosti razlichnykh proizvodnykh al'fa-tokoferola v preduprezhdenii éksperimental'noĭ myshechnoĭ distrofii u tsypliat.