[Renal lesions after irradiation and chemotherapy with adriamycin, vincristin and 5-fluoro-uracil (author's transl)].
After hysterectomy and bilateral annexectomy for bilateral ovarian carcinoma, a 34 years old woman was treated by radiotherapy and chemotherapy associating adriamycin, vincristin and 5-fluoro-uracil. After this treatment, proteinuria and progressive renal failure developed. Renal biopsy showed prominent glomerular lesions with mesangiolysis and some necrotic arteriolar lesions. The role of radiotherapy and chemotherapy in the pathogenesis of these lesions is discussed.
D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology; D000328:Adult; D004317:Doxorubicin / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000648:ultrastructure; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects; D014750:Vincristine / Q000009:adverse effects*
D014750:Vincristine; D004317:Doxorubicin; D005472:Fluorouracil
Atteinte rénale après irradiation et chimiothérapie par l'adriamycine, la vincristine et le 5-fluoro-uracile.