Oral bioavailability of theophylline from hydroalcoholic and alcohol-free preparations.
We investigated the bioavailability of theophylline in eight healthy subjects following the oral administration of theophylline (128 mg) in hydroalcoholic (Brondecon elixir) and alcohol-free (Nuelin syrup preparations. The trial was open, randomised and cross-over. Theophylline was rapidly absorbed from both preparations. Bioavailability was assessed by measuring peak theophylline concentration, time to peak, absorption half-life and area under the curve. We concluded that the bioavailability of theophylline from each orally administered product was similar.
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D000431:Ethanol / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D014677:Pharmaceutical Vehicles; D013806:Theophylline / Q000097:blood / Q000378:metabolism*
D014677:Pharmaceutical Vehicles; D000431:Ethanol; D013806:Theophylline