Synthesis and properties of human growth hormone fragments.
The solid phase synthesis of fragments 75-120-NH2 and 73-128-GlyNH2 of the human growth hormone sequence is described. Purification was by solvent extraction, gel filtration and partition chromatography. No growth-promoting activity was detected in any of the peptides by the rat body-growth assay. An immunochemically reactive area was located in the sequence 73-128 when tested by complement fixation assays.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002845:Chromatography; D005260:Female; D013006:Growth Hormone / Q000138:chemical synthesis* / Q000494:pharmacology / Q000031:analogs & derivatives; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D000596:Amino Acids; D010446:Peptide Fragments; C034422:somatotropin (75-120); C034423:somatotropin (73-128) glycinamide; D013006:Growth Hormone