Comparative in vitro evaluation of six commercial vincamine prolonged-release dosage forms.
This study consisted of a comparison of the release rates of six commercial brands of prolonged-release vincamine. The pH of the dissolution medium was found to be highly significant. Due to the low solubility of vincamine in media close to the neutral point, all of the preparations tested, with the exception of one, showed highly variable release curves under the three pH conditions chosen.
D003692:Delayed-Action Preparations; D004339:Drug Compounding; D006863:Hydrogen-Ion Concentration; D012995:Solubility; D013557:Switzerland; D013997:Time Factors; D014748:Vinca Alkaloids / Q000008:administration & dosage*; D014749:Vincamine / Q000008:administration & dosage*
D003692:Delayed-Action Preparations; D014748:Vinca Alkaloids; D014749:Vincamine