title: Cimetidine impairs the elimination of chlormethiazole.
abstract: Cimetidine impairs the systemic clearance of a number of low extraction drugs and this study examines its effect on the oral clearance of the high extraction drug, chlormethiazole. Cimetidine (1 g/day for 7 days) caused the clearance of chlormethiazole to fall to 69% of pretreatment values. It also prolonged the elimination half-life by 60%. The findings indicate that the metabolism of chlormethiazole is inhibited by cimetidine and the co-administration of these drugs may lead to excess sedation and respiratory depression.
mesh_terms: D000328:Adult; D002719:Chlormethiazole / Q000378:metabolism*; D002927:Cimetidine / Q000009:adverse effects*; D004347:Drug Interactions; D006146:Guanidines / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects
chemical_list: D006146:Guanidines; D002719:Chlormethiazole; D002927:Cimetidine