Serum levels and clearance of bile acids are unaffected by jejunoileal bypass with 3:1 or 1:3 jejunoileal ratio.
Jejunoileal bypass may impair liver function. The hypothesis of the present study was that this may depend on the jejunoileal ratio of the segment left in continuity in a manner that affects the transport of bile acids from blood to bile. We investigated five extremely obese patients before and 29 patients 3, 9 and 15 months after bypass surgery with a 3:1 or 1:3 jejunoileal ratio of the functioning segment. Routine liver function tests, plasma disappearance rate of intravenously administered 3H-cholic acid and 14C-24-chenodeoxycholic acid, and fasting and postprandial serum concentrations of total 3-alpha-hydroxy bile acids showed no appreciable significant relationship with bypass surgery as such, time after surgery, or the jejunoileal ratio of the functioning segment.
D000328:Adult; D001647:Bile Acids and Salts / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D007082:Ileum / Q000601:surgery*; D007583:Jejunum / Q000601:surgery*; D008099:Liver / Q000503:physiopathology; D008111:Liver Function Tests; D008657:Metabolic Clearance Rate; D009765:Obesity / Q000503:physiopathology / Q000628:therapy*
D001647:Bile Acids and Salts