Effects of orally administered psychotropic drugs on dog conditioned avoidance responses.
Orally administered haloperidol, chlorpromazine, thioridazine, clozapine, and diazepam blocked a conditioned avoidance response in male beagle dogs. All compounds except diazepam also inhibited escape behavior. Avoidance blocking does of haloperidol, chlorpromazine, and thioridazine in dogs were similar o human therapeutic dosage ranges for these drugs. The usefulness of shock avoidance by dogs as a predictor of human dosage and side effects for major tranquilizers is discussed.
D000284:Administration, Oral; D000818:Animals; D001259:Ataxia / Q000139:chemically induced; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D004285:Dogs; D009949:Orientation / Q000187:drug effects; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D011680:Pupil / Q000187:drug effects
D011619:Psychotropic Drugs