title: The quantitative effects of the B blood group locus and sex linked histocompatibility antigen in chickens on G-v-H reaction.
abstract: The major histocompatibility locus in the chicken is the B locus with a minor histocompatibility antigen controlled by a gene (s) on the  W chromosome. This study was designed to determine the quantitative effects of the B locus and the sex linked histocompatibility gene on splenomegaly of chick embryos after inoculation with adult male lymphocytes. The embryos and male lymphocyte donors had blood group genotypes designed B9/B9, B9/B11 so that nine donor-host combinations were used. When the donor and host were homozygous for different B alleles (B9 and B11) or different by one B allele (B9 or B11) the splenomegaly was 4 and 2 times greater, respectively, than the compatible donor and host. A greater splenomegaly was produced in male to female injections than in male to male injections. However, the histocompatibility antigen controlled by a gene(s) on the W chromosome was weaker than the controlled by the B locus.
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D000483:Alleles; D000818:Animals; D002642:Chick Embryo; D002645:Chickens; D005260:Female; D005796:Genes; D005838:Genotype; D006087:Graft vs Host Reaction; D006649:Histocompatibility Antigens / Q000235:genetics* / Q000276:immunology; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology; D008285:Major Histocompatibility Complex; D008297:Male; D012737:Sex Factors; D013163:Splenomegaly / Q000235:genetics / Q000276:immunology
chemical_list: D000017:ABO Blood-Group System; D006649:Histocompatibility Antigens