title: [The Pelger-Huet granulocytic anomaly: first report of 2 homozygous subjects in the same family].
abstract: Pelger-Huet granulocyte anomaly is characterized by the presence of granulocytes with a non segmented nucleus and thick nuclear chromatin gathered in large lumps. In human we known two forms of the anomaly: the heterozygous form often described by many authors, and the homozygous form, very rare. With regard to morphology, the homozygous form is characterized by granulocytes with round nucleus and very coarse chromatin. In this report the presence of two homozygous carriers of the anomaly in the same family is discussed.
mesh_terms: D000368:Aged; D005260:Female; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D010381:Pelger-Huet Anomaly / Q000235:genetics*
vernacular_title: L'anomalia granulocitaria di Pelger-Huet: prima segnalazione di due soggetti omozigoti nella stessa famiglia.