Thiobarbituric acid reactive material in uremic blood.
The thiobarbituric acid (TBA) assay was applied to uremic blood. Significant TBA-reactive material was found in patients with chronic renal failure compared to normal controls. The presence of TBA-reactive material correlated with the degree of renal failure, and was removed by hemodialysis. The reactive material is not 2-deoxyribose or sialic acid. In addition, the presence of TBA-reactive material in uremic blood is not abolished by prior aspirin ingestion, suggesting it is not related to active prostaglandin synthesis. The possible origin of the TBA-reactive material in uremic blood is discussed.
D000328:Adult; D003404:Creatinine / Q000097:blood; D003855:Deoxyribose / Q000378:metabolism; D006801:Humans; D007674:Kidney Diseases / Q000097:blood; D011897:Random Allocation; D006435:Renal Dialysis; D012794:Sialic Acids / Q000378:metabolism; D013858:Thiobarbiturates / Q000378:metabolism; D014511:Uremia / Q000097:blood*
D012794:Sialic Acids; D013858:Thiobarbiturates; D003855:Deoxyribose; D003404:Creatinine; C029684:thiobarbituric acid