Nocodazole entrapped into liposomes: no more effect on human CFU-C than free nocodazole.
Nocodazole, a water insoluble antimitotic drug active on L1210 leukemia was incorporated into liposomes, to investigate whether this procedure could increase cellular uptake. The effects of micronized nocodazole and liposome-entrapped nocodazole were compared on human marrow cells in vitro using a myeloid progenitor cell assay (CFU-C). The human CFU-C were sensitive to the micronized drug in a dose-related fashion. However, contrasting with a previous report on L 1210 leukemia, entrapping of nocodazole into liposomes did not increase its activity of CFU-C of either normal or leukemic subjects.
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001562:Benzimidazoles / Q000008:administration & dosage* / Q000627:therapeutic use; D002219:Carbamates / Q000008:administration & dosage* / Q000627:therapeutic use; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008081:Liposomes / Q000008:administration & dosage*; D015739:Nocodazole
D000970:Antineoplastic Agents; D001562:Benzimidazoles; D002219:Carbamates; D008081:Liposomes; D015739:Nocodazole