Ventricular size and intelligence in achondroplasia.
Of 10 children with macrocephaly in association with achondroplasia only two children had progressive hydrocephalus. They were treated with a shunt procedure. One of these is intellectually and neurologically normal, and one is wheelchair bound and mentally retarded, with a spastic quadraplegia. Three children showed mild dilatation of the ventricles and one of these died from severe constriction at the foramen magnum. The other two are neurologically normal; one is intellectually normal but below average (WISC 88) and the other is slow normal at 18 months of age. Four children with demonstrated megalencephaly and a fifth with probable megalencephaly are all intellectually and neurologically normal. Intelligence in achondroplasia appears to be mainly in the normal range.
D000130:Achondroplasia / Q000150:complications* / Q000473:pathology; D002508:Cephalometry; D002552:Cerebral Ventricles / Q000473:pathology*; D005260:Female; D005539:Foramen Magnum / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000209:etiology; D007360:Intelligence; D008297:Male; D011782:Quadriplegia / Q000209:etiology